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  1. QING LIN

    Indian Academy of Sciences (India)

    QING LIN. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ZHENG ZI-JING ZHANG YONG-LONG DANG ...

  2. Editor\\'s welcome

    Directory of Open Access Journals (Sweden)

    Hassan Mozaffari-Khosravi

    2016-10-01

    Full Text Available Food and Nutrition Security (FNS has an evolving nature and during the last decades its theoretical, conceptual, structural, practical and programmatic notions evolved significantly and approaches toward food and nutrition have changed drastically. Now, more than ever before, the issue is considered as a fundamental component of sustainable development globally. For a better grasp of the complexities of the field, we need to remind ourselves that “nutrition” as science has a history of more than 100 years while nutrition as a “factor” in “National development” has a history of around fifty years. Considering distinct levels of development status in different contexts, FNS pattern is non-monotonic even in one country. Accordingly, struggling against food and nutrition insecurity is very thought to deal with and multi disciplinary and multi sectorial approaches should be applied. Providing robust evidences to feed policy making processes is one of the main prerequisites for evidence informed policy making and repositioning nutrition as central to sustainable development. This is a professional duty of scholars in different sectors engaging with human development. The journal of Nutrition and Food Security (JNFS as a new journal in the field of food and nutrition security is trying to provide an excellent opportunity for researchers and scholars to publish their original works on approaches, challenges and solutions of food and nutrition hoping to provide data for decision makers to better design interventional programs aiming to eradicate food and nutrition insecurity. Editor in chief H. Mozaffari-Khosravi 22 Sep 2016

  3. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Readers, Welcome to the Volume 14 Number: 2 of TOJDE! In this issue, 3 Notes for Editor, 2 Book Reviews and 21 articles of 40 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from Argentina, Australia, Bosnia Hersek, Egypt, India, Malaysia, Romania, Saudi Arabia, Tanzania, Thailand, Turkey, United Arab Emirate and USA. The 1st Notes for Editor is arrived from USA and written by Gail D. CARUTH,...

  4. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2012-04-01

    Full Text Available Dear TOJDE Readers,Welcome to the Volume 13 Number: 2 of TOJDE! In this issue, 7 notes for Editor and 22 articles one book review of 57 authors from 12 different countries have been published. These published articles are from, Barbados, Ethiopia, India, Indonesia, Iran, Nigeria, Pakistan, Russia, Saudi Arabia, Turkey, USA and Zimbabwe.In general, around 13 articles and 4 notes for editors have been published in TOJDE so far. I would like to explain, why this time 22 articles and 8 submissions published in the articles and in notes for Editor Section respectively. First all, you should know that if a submission picks up from 3 TOJDE editors between 4.5 and 9 over all 9 credits, it means that this submission can be published in TOJDE in the coming issue. However, since the publishing priority of the accepted papers belongs to the highest scored ones, submissions which receive a score between 4.5 and 5 or 6 may wait and be archived for publishing later on. TOJDE administration respected this publishing rule up to now. Therefore, some accepted submissions which obtained over 4.5 have not been published up to now. These submissions were waiting for publishing in TOJDE in the future. In this issue, we decided to give them a chance to be published. For this reason, the current issue includes more papers than the previous issues. The 1st Notes for editor arrived from Russia written by Galina ARTYUSHINA and Olga SHEYPAK on Impacting Motivation In The Virtual Classroom. They mentioned that teachers, educational managers and learners must realize that new opportunities are offered by modern on-line communication. A person with basic Internet and Web skills is open to a new world of knowledge, from free Web surfing and self-organized education - through on-line resources and familiarization with Internet culture, its places, sites, search engines etc. - up to a more structured approach. The 2nd notes for editor is titled as “Use Of Libraries In Open And

  5. From Editor

    OpenAIRE

    Ugur DEmiray

    2011-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 12, Number: 1. In this issue it is published 4 notes for Editor, 13 articles, 2 book reviews. And this time, 34 authors from 11 different countries are placed. These published articles are from Cayman Islands, Germany, Greece, India, Iran, Malaysia, Pakistan, Turkey, USA and Zimbabwe.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on “SNAPP:Graphing Student Interactio...

  6. From Editor

    OpenAIRE

    Ugur DEMIRAY

    2012-01-01

    Turkish Online Journal of Distance Education-TOJDE July 2012 ISSN 1302-6488 Volume: 13 Number: 3 from EditorDear TOJDE Readers,Welcome to the Volume 13 Number: 3 of TOJDE! In this issue, 2 Notes for Editor and 26 articles of 51 authors from 14 different countries around the world have been published. These published articles are from, Algeria, Australia, Bengaldesh, Greece, India, Iran, Malaysia, Mariutius, Nigeria, Oman, Spain, Turkey, USA and Zimbabwe.First all, you should know that if a su...

  7. From Editor

    OpenAIRE

    Ugur Demiray

    2012-01-01

    Dear TOJDE Readers,Welcome to the Volume 13 Number: 2 of TOJDE! In this issue, 7 notes for Editor and 22 articles one book review of 57 authors from 12 different countries have been published. These published articles are from, Barbados, Ethiopia, India, Indonesia, Iran, Nigeria, Pakistan, Russia, Saudi Arabia, Turkey, USA and Zimbabwe.In general, around 13 articles and 4 notes for editors have been published in TOJDE so far. I would like to explain, why this time 22 articles and 8 submission...

  8. From Editor

    OpenAIRE

    Ugur Demiray

    2010-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now again after 3 months as Volume 11, Number: 2. This is the second issue of the year 2010. In this issue it is published four Notes for Editor, fourteen articles and four book reviews. And this time, 37 authors from 8 different countries are placed. These published articles are from Greece, Indonesia, Iran, Malaysia, Pakistan, Saudi Arabia, USA and Turkey.Again Kevin YEE & Jace HARGIS have sent a good and short note to editor ...

  9. Editor's Note

    African Journals Online (AJOL)

    On another note: the editor and the editorial team acknowledge the financial support of the Carnegie Corporation of New York through the University of Ghana Building A New Generation of Academics in Africa (BANGA-Africa) Project. We also use this platform to express our gratitude for the support of various stakeholders, ...

  10. From Editor

    OpenAIRE

    Ugur Demiray

    2009-01-01

    TOJDE is appeared on your screen now as Volume 10, Number: 1. This is the first issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published four article are in “Notes for Editor Sectio”, 13 articles, 2 reviews. And this time, 26 authors from twelwe different countries are placed. These published articles are from Australia, Botswana, Canada, Italy India, Jordan, Malaysia, Nigeria, Srilanka, USA and Turkey. “Service Learning In Distance Education: Foreign Language Lear...

  11. Fnom Editor

    OpenAIRE

    Ugur Demiray

    2006-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared as Volume 7, Number: 1 on your screen now as. Very much thanks to all of you once more that we met 21st time, since January 2000. In this issue we published 15 articles, four book reviews, one notes for editor, news and announcements for our readers. And also, we give a place for the Call for Papers to the 4th Special Issue of The Turkish Online Journal of Distance Education (TOJDE) ...

  12. From Editor

    OpenAIRE

    Ugur Demiray

    2008-01-01

    Greetings Dear readers of TOJDE, TOJDE is appeared on your screen now as Volume 9, Number: 4. This is the fourth and the last issue of the year 2008. In this issue it is published two notes for Editor, 13 articles, 2 reviews. And this time, 23 authors from seven different countries are placed. These published articles are from Bangladesh, India, Malaysia, Nigeria, Saudi Arabia, USA and Turkey. “Ubiquitous, Free, And Efficient Online Collaboration Tools For Teaching And Learning” has sent to e...

  13. Editor's Note

    Directory of Open Access Journals (Sweden)

    Daniel Shanahan

    2016-07-01

    Full Text Available CORPUS studies have increasingly been of interest to music theorists, musicologists, and music psychology researchers, as is evident in the sheer number of excellent submissions to this special issue. The breadth and depth of these articles, as well as the insightful commentaries, make it seem only fitting to publish over two issues. The current issue contains five articles, eight commentaries, and one research report, and covers folk music, post-tonal music, jazz, Western art music, and the popular music found on Youtube. Eerola presents a model of melodic entropy that provides a nice framework for future information-theoretic work, while Roger Dean and Marcus Pearce present a new approach to modelling pitch-structure in post-tonal music. Frieler, Pfleiderer, Abeßer, and Zaddach give an analysis of jazz solos that demonstrates the role of a narrative arcs in improvisation. White and Quinn present a new corpus that makes use of vast compilations of web-based MIDI data, and demonstrates how such a corpus might be facilitate future musicological and music-theoretic research. Plazak focuses on Youtube as a corpus, and argues that the mutability of such a corpus facilitates our understanding of musical communication, as well as the important role of the listener in defining and re-defining such a dataset. It's encouraging to me both as an editor and practitioner of corpus methods that so many of those heavily involved with the field contributed to these two issues as either an author or a commentator. This issue also brings a number of changes on other fronts. Firstly, Nicola Dibben and Renee Timmers, who served as the journal's editors since Volume 7, have completed their editorial terms. They oversaw the transformation of the journal into a new Open Journal Systems platform, and were able to consistently produce issues that set a very high standard. Under their leadership, the journal both increased its accessibility (we now average more than 1

  14. Guest editor

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1995-07-15

    Full text: Guest Editor for this special issue of the CERN Courier on the applications of accelerators was Dewi M. Lewis of Amersham International pic, UK. Dr. Lewis was educated at the Physics Department, University of Wales, Swansea, and learnt his accelerator physics as Engineer-in- Charge at the CERN Intersecting Storage Rings before joining industry in 1979 at the beginning of the boom for commercial cyclotrons. Having managed the installation of Amersham's second and third isotope production cyclotrons in the UK, his industrial experience encompassed isotope manufacturing and business management in radiopharmaceuticals and organization of joint ventures. Following closure of several research reactors in 1990, his responsibilities extended to reactor isotope production as well as technology transfer with international laboratories. He was responsible for creation of the first Russian 'weapons to ploughshares' joint venture with the Radioisotope Association, Mayak and the Russian Atomic Energy Ministry. Dr. Lewis currently chairs the European Radiopharmaceutical Industry's committee on future reactor isotopes and is currently involved in the technical development for accelerator technology. Amersham International is one of the world's leading isotope companies, engaged in development, manufacturing, international sales and distribution of radioisotope products in markets for healthcare, research compounds and industrial products. Formerly part of the United Kingdom Atomic Energy Agency, Amersham was one of the first companies to be privatized in 1982.

  15. Guest editor

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    Full text: Guest Editor for this special issue of the CERN Courier on the applications of accelerators was Dewi M. Lewis of Amersham International pic, UK. Dr. Lewis was educated at the Physics Department, University of Wales, Swansea, and learnt his accelerator physics as Engineer-in- Charge at the CERN Intersecting Storage Rings before joining industry in 1979 at the beginning of the boom for commercial cyclotrons. Having managed the installation of Amersham's second and third isotope production cyclotrons in the UK, his industrial experience encompassed isotope manufacturing and business management in radiopharmaceuticals and organization of joint ventures. Following closure of several research reactors in 1990, his responsibilities extended to reactor isotope production as well as technology transfer with international laboratories. He was responsible for creation of the first Russian 'weapons to ploughshares' joint venture with the Radioisotope Association, Mayak and the Russian Atomic Energy Ministry. Dr. Lewis currently chairs the European Radiopharmaceutical Industry's committee on future reactor isotopes and is currently involved in the technical development for accelerator technology. Amersham International is one of the world's leading isotope companies, engaged in development, manufacturing, international sales and distribution of radioisotope products in markets for healthcare, research compounds and industrial products. Formerly part of the United Kingdom Atomic Energy Agency, Amersham was one of the first companies to be privatized in 1982

  16. from editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2007-07-01

    Full Text Available Greetings Dear Readers of TOJDE, First of all, please accept my excuse for the reason that the first time TOJDE is a few days delayed to reach its readers in its publication life. I am the most responsibility person for this delaying July 2007 issue of TOJDE is on your screen now again. This is a special issue on the theme on “Web 2.0 and Social Software in Distance Education”, as being Vol. 8, No. 3. Preparing of this special issue took nearly eight months, from the beginning to the arrival to your screen. A short story of this special issue is here if you are interested in. First idea and suggestion came from me to my dear colleagues, Dr. Mark J. W. LEE who is from Charles Sturt University, New South Wales, AUSTRALIA and Dr. Hakan G. SENEL from Turkey, who is Director at the Computer Research and Development Center (BAUM of Anadolu University. After, we agreed on the topic all together we started to announcing as a call for paper at many medium, institutions, governmental or non- governmental organizations, experts, and so on. The seven articles and one study (at “notes for Editor” section published in this special issue were written by twenty authors, from 7 different countries include Australia, Italy, The United Kingdom, Turkey and USA. In addition, two book reviews is also published. I would like to express my sincere thanks that goes to each of them, and valuable panelists for this special issue, in the name of my university and TOJDE. I strongly believe that experience gained on this special issue would encourage us and other interested colleagues in the field for the near future. Below you will find short biodata on my valuable guest editors. Mark J. W. LEE is an Adjunct Lecturer with the School of Education, Charles Sturt University, and an Honorary Research Fellow with the School of Information Technology and Mathematical Sciences, University of Ballarat. He was previously a Lecturer in Information Technology in the School of

  17. Editor's preface

    International Nuclear Information System (INIS)

    Greiner, W.

    2001-01-01

    -energy heavy ion collisions. This symposium was meant as a token of appreciation for his life, his work and his personality by his friends and colleagues. Mike certainly would have enjoyed the fine talks, the lively discussions, the excursion to the Oelberg, and the hospitable setting at the DPG conference center. My special thanks go to the Wilhelm und Else Heraeus Stiftung for its generous support, which made this symposium possible. I want to express my gratitude to Johann Rafelski, Tucson, for his advice. Thanks are also due to Mathias Brandstetter for his assistance in organizing the conference and to Joachim Reinhardt for his help in preparing the proceedings. Finally, I acknowledge the agreeable collaboration with Istvan Lovas, editor-in-chief of Heavy Ion Physics. (author)

  18. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur DEMIRAY

    2012-07-01

    Full Text Available Turkish Online Journal of Distance Education-TOJDE July 2012 ISSN 1302-6488 Volume: 13 Number: 3 from EditorDear TOJDE Readers,Welcome to the Volume 13 Number: 3 of TOJDE! In this issue, 2 Notes for Editor and 26 articles of 51 authors from 14 different countries around the world have been published. These published articles are from, Algeria, Australia, Bengaldesh, Greece, India, Iran, Malaysia, Mariutius, Nigeria, Oman, Spain, Turkey, USA and Zimbabwe.First all, you should know that if a submission picks up from 3 TOJDE editors between 4.5 and 9 over all 9 credits, it means that this submission can be published in TOJDE in the coming issues. However, since the publishing priority of the accepted papers belongs to the highest scored ones, submissions which receive a score between 4.5 and 5 or 6 should wait and be archived for publishing later on. TOJDE administration respected this publishing rule up to now. Therefore, some accepted submissions which obtained over 4.5 have not been published yet up to now. These submissions were waiting for publishing in TOJDE in the future. In this issue, we decided to give them a chance to be published. For this reason, the current issue includes more papers than the previous issues. The 1st Notes for editor arrived from USA and written by Steve McCREA on Transforming Teachers, Transforming Schools: Turning "Sages" Into "Guides on The Side". He mentioned that teachers, educational managers and learners must realize that new opportunities are offered by modern communication. When a teacher becomes a "guide on the side," there is a change in the school's culture that can be measured. This presentation is extracted from a newly published book, Let's Lecture Less, edited by Steve McCrea (Visualandactive.com and Mario Joel Llorente Leyva. The 2nd notes for editor is titled as “Challenges Encountered By A Distance Learning Organisation” which is written by Dr. Sangeeta MALIK, from Education, Humanities and

  19. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2009-01-01

    Full Text Available TOJDE is appeared on your screen now as Volume 10, Number: 1. This is the first issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published four article are in “Notes for Editor Sectio”, 13 articles, 2 reviews. And this time, 26 authors from twelwe different countries are placed. These published articles are from Australia, Botswana, Canada, Italy India, Jordan, Malaysia, Nigeria, Srilanka, USA and Turkey. “Service Learning In Distance Education: Foreign Language Learning Environments” has sent to editor of TOJDE from Turkey and written by Muhlise Coşgun OGEYIK from Trakya University, Faculty of Education Edirne, TURKEY and Emre GUVENDIR from University of California. Their paper provides an overview in general education, in particular foreign language education, can be acknowledged as a lifelong learning process which can be transformed beyond the borders in global sense. Learning a foreign language requires proficiency in four basic skills which are reading, writing, speaking, and listening. Of these skills, speaking and listening are the most daunting tasks for learners and create obstacles when learners of target language do not get the chance of meeting native speakers. Such obstacles can be overwhelmed by integrating certain applications into education process. Service-learning through the internet as a teaching method can be considered one of the most striking one of those applications for foreign language learners. Paper focuses on the benefits of service-learning are discussed and some suggestions are offered for introducing this method in foreign language settings. The second notes for editor is titled as Students’ Opinions On Blended Learning which is written by Meric BALCI and Haluk SORAN from Hacettepe University, Education Faculty, Ankara,Turkey. They mentioned that E-learning was acknowledged by most educators and researchers as a savior, even an only alternative in education field, especially in

  20. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-04-01

    Full Text Available Dear TOJDE Readers, Welcome to the Volume 14 Number: 2 of TOJDE! In this issue, 3 Notes for Editor, 2 Book Reviews and 21 articles of 40 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from Argentina, Australia, Bosnia Hersek, Egypt, India, Malaysia, Romania, Saudi Arabia, Tanzania, Thailand, Turkey, United Arab Emirate and USA. The 1st Notes for Editor is arrived from USA and written by Gail D. CARUTH, Department of Educational Leadership Texas A&M University and Donald L. CARUTH Texas USA, from Independent Management Consultant, on “Understanding Resistance To Change: A Challenge For Universities”. This paper explores organizational change and the challenge it poses for universities. Because universities are slow to change due to maintaining a balance of tradition and change successful implementation of change will continue to be a challenge both now and in the future. The challenge of change is real but the task is not impossible. Historically, universities have met the challenges that faced them, they must be prepared to confront this challenge too. The 2nd Notes for Editor is arrived from UAE, in the context of “iPAD LEARNING ECOSYSTEM: Developing Challenge-Based Learning using Design Thinking” which iritten by Catalina MARIN, Jace HARGIS and Cathy CAVANAUGH,HCT ADWC, Abu Dhabi, UAE. This article describes the course design, which was grounded in design thinking, and provides an overview of the pilot implementation of the course. The course achieved its goals to a great extent in that learners felt that they were beginning to help build a better college community by sharing stories of their learning experience and their insights about the essential question they chose with other students and with other teachers. Third Notes for Editor titled as “ Use of Distance Education By Chritian religion to Train Edify and Educate Adherents” and written by Dr. P

  1. Fnom Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2006-01-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared as Volume 7, Number: 1 on your screen now as. Very much thanks to all of you once more that we met 21st time, since January 2000. In this issue we published 15 articles, four book reviews, one notes for editor, news and announcements for our readers. And also, we give a place for the Call for Papers to the 4th Special Issue of The Turkish Online Journal of Distance Education (TOJDE (Volume: 7, Number: 2 To be delivered in April 2006. The first article is coming from The Robert Gordon University, Scotland, United Kingdom which is written by Geoff GOOLNIK. He is tutor at Centre for the Enhancement of Learning and Teaching (CELT. His article titled as “Effective Change Management Strategies for Embedding Online Learning within Higher Education and Enabling the Effective Continuing Professional Development of its Academic Staff”. According to Goolnik, “Previous research studies show that those universities wishing to successfully engage in online learning will have to adopt and implement tactics that have the capacity to overcome existing social and cultural constraints. An inclusive, consultative framework needs to be established, and Continuing Professional Development (CPD has been recognized as a key concern that should be addressed here. Second article is dealt with some problems of DE in Nigeria by Dr. Mudasiru Olalere YUSUF in his study which entitled as “Problems and Prospects of Open And Distance Education in Nigeria” He is from Department of Curriculum Studies and Educational Technology, Faculty of Education University of Ilorin, Nigeria. His article explores that the major terms inherent in open and distance education, its potentials, possible factors that may inhibit successful implementation of the programme, and the use of low and high technological tools for its implementation, by adding of his recommendations. And than

  2. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2010-04-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now again after 3 months as Volume 11, Number: 2. This is the second issue of the year 2010. In this issue it is published four Notes for Editor, fourteen articles and four book reviews. And this time, 37 authors from 8 different countries are placed. These published articles are from Greece, Indonesia, Iran, Malaysia, Pakistan, Saudi Arabia, USA and Turkey.Again Kevin YEE & Jace HARGIS have sent a good and short note to editor of TOJDE from USA. Their paper involve on YouTube and Video Quizzes. They mentioned YouTube videos can be employed to introduce a subject, such as framing the context, or simply to pique curiosity. Or, they may be shown after a principle has been taught, and now needs to be applied in a case study and defense the advantages of this type of formative assessment include both increasing the stimuli and subsequent attention of the student, as well as requiring continual engagement, which produces critical information, and allows students to more fully self-regulate their own conceptual understanding, so they can move forward in their learning with an increased level of awareness of what they know and do not know.The second notes for editor is titled as “COMPARATIVE STUDY OF THE USE OF ICT IN ENGLISH TEACHING-LEARNING PROCESSES” which is written by Abbas ZARE-EEand Abbas SHEKAREY, from rhe Universİty of Kashan, Kashan, Iran. They mentioned in their paper to compare the amount and quality of ICT use in English teaching-learning processes among the faculty members of Medical and Non-medical Universities in Kashan, Iran and to explore the dimensions in which the two groups can benefit from one another and from ICT training in this respect. The results of the analyses showed that there was a significant difference in the amount of ICT use among the faculty members of medical and non-medical universities. Results also indicated that there was a significant

  3. Editors page

    Directory of Open Access Journals (Sweden)

    Margarita Barretto

    2007-12-01

    Full Text Available Entregamos o segundo número da Revista Brasileira de Pesquisa em Turismo- RBTur, inaugurada oficialmente com o primeiro número no dia 25 de agosto de 2007, que coincide com importantes datas no relacionamento das pessoas com as viagens e o turismo. Neste dia, em 1768, o Capitão James Cook, empreende sua primeira viagem transoceânica na sua nave Endeavour. No transporte terrestre, em 1910, funda-se a companhia Yellow Cab nos Estados Unidos. No ar, em 1919, inaugura-se a aviação comercial, quando um avião civil (Havilland transporta passageiros de Londres a Paris. É uma data também importante para as mulheres aviadoras; em 1920 Adrienne Bolland será a primeira figura feminina a atravessar de avião o Canal da Mancha e, em 1932, Amélia Earhart realizará o primeiro vôo sem paradas através do território dos Estados Unidos. Finalmente, no espaço, no dia 25 de agosto de 1989, a sonda Voyager 2 chega a Netuno. Também para os novos paradigmas do turismo, como a preservação da natureza, a data é importante, pois marca a criação do Serviço de Parques Nacionais, nos Estados Unidos, em 1916, que servirá de modelo aos demais países do mundo. Precedida de tantas efemérides transcendentes, a nossa revista tem a responsabilidade de deixar para o futuro uma marca de qualidade acadêmica e inovação científica, que pretendemos cumprir apoiados nos excelentes pesquisadores que há no Brasil e nos países vizinhos, assim como aqueles consagrados no primeiro mundo que nos prestigiam com intercâmbios culturais há tantos anos. O primeiro número teve impressionante acolhida, tendo os editores recebido mails elogiosos de todo o país, assim como da Nova Zelândia, do México, da Espanha, da Argentina, entre outros, de cientistas provenientes das mais diversas áreas, refletindo o sucesso da nossa abordagem multidisciplinar sobre o turismo. Neste segundo número, apresentamos estudos inovadores referentes a aspectos simbólicos do turismo

  4. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2007-10-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 8th year of TOJDE are appeared on your screen now as Volume 8, Number: 4. Ti is the last issue of the year 2007. As you volume ( Number 3 was the special issue of TOJDE on “Web 2.0 and Social Software in Distance Education” subject. I received many congrulation for this special issue from the subject expert and TOJDE readers. During 6 months I received more than 45 submissions. Some of them rejected by me for the reason that their subjects were not fit for TOJDE’s publishing content strategy, and some of them rejected by TOJDE’s editors. And others can be publish next year’s issues In this issue we published one notes for Editor, 13 articles, already one review (maybe I can update for one or two reviews in due course which I am waiting from my book reviewers, news and announcements for our readers. This time 24 authors from eighth different countries are placed in this issue. These published articles are from Australia, Gana, Indonesia, Malaysia, Nigeria, Pakistan, Turkey, and UK. The first article of this issue is coming from Faculty of Education, Monash University, Victoria, AUSTRALIA. Article is entitled as “Globalization, Distance Education And Hegemonic Futures” and written by Dr. Glenn RUSSELL. He says in his paper that “Available options for distance educators can be understood in terms of instrumental and interpersonal axes that can potentially indicate the relative consideration that can be given to these factors. This approach is suggested as one way to understand available options at a time when there has been an apparent increase in instrumental approaches to distance education at the expense of interpersonal approaches and issues of social justice. While this problem is of concern, it is more appropriate to reflect on the unintended consequences of distance education for society and identify them than it is to uncritically oppose globalisation

  5. LINS Curve in Romanian Economy

    Directory of Open Access Journals (Sweden)

    Emilian Dobrescu

    2016-02-01

    Full Text Available The paper presents theoretical considerations and empirical evidence to test the validity of the Laffer in Narrower Sense (LINS curve as a parabola with a maximum. Attention is focused on the so-called legal-effective tax gap (letg. The econometric application is based on statistical data (1990-2013 for Romania as an emerging European economy. Three cointegrating regressions (fully modified least squares, canonical cointegrating regression and dynamic least squares and three algorithms, which are based on instrumental variables (two-stage least squares, generalized method of moments, and limited information maximum likelihood, are involved.

  6. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-07-01

    interviews. Frequencies and percentages were used to analyze the categorical data. Moreover, the qualitative data was analyzed via content analysis. According to the findings of the study, students needed to get support about education directives, career guidance, technical equipment, and personal problems. In this issue we published two book reviews. The first issue on “UNIVERSITY TEACHING IN FOCUS:A Learning-centred Approach” which is edited by Lynne HUNT and Denise CHALMERS and reviewed by S. K. PULIST from india. He empasises about the book that The book as the name depicts, focuses on different aspects of university teaching from learner-centred point of view. A wise range of issues has been highlighted and properly addressed by the authors in a very diligent manner. It will help the teachers in constructively engaging the students in effective learning. It is a step forward towards empowering the upcoming teachers with necessary strategies and stand point so that they are able to help the students in enhancing their quality learning. The book would be helpful not only to the novice teachers who have just stepped in the teaching profession but also other stakeholders of higher education system. 2nd book review is on “TRENDS AND ISSUES IN DISTANCE EDUCATION: International Perspectives, Second Edition”, edited by Lya Visser, Yusra Visser, Ray Amirault & Michael Simonson and Reviewed by Dr. Dilek ALTUNAY from Mustafa Kemal University, Hatay, TURKEY. She mentioned about the book that this book makes a contribution to the field of distance education by offering a comprehensive overview and analysis of the current trends and issues in distance education. In addition, the book is well-organized and coherent in terms of presentation. The reader is guided by section editors who provides introduction to the section and an overview of the chapters in the section, which makes the book reader-friendly. To receive further information and to send your recommendations and

  7. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2014-04-01

    University, Bayburt, TURKEY. The aim of the study is to reveal the students’ views who are studying in different departments of distant education programs provided by Anadolu University in TURKEY. Qualitative research method was used in the study and purposeful sampling was followed. The research was conducted with 10 students who were working in different jobs and taking distance education courses in different departments. The findings obtained as a result of data analysis were examined, the students taking distance education courses in different departments stated that this education method was a great opportunity and chance for them. To receive further information and to send your recommendations and remarks, or to submit articles for consideration, please contact tojde secretariat at the below address or e-mail us to tojde@Anadolu.Edu.Tr Hope to stay in touch and meet in our next issue, on 1st of July 2014. Cordially, Prof. Dr. Ugur Demiray, Editor-In-Chief of TOJDE Anadolu University, Yunusemre Campus 26470 Eskisehir TURKEY Tel: +90 222 335 0581 Ext. 5262 GSM: +90 542 23 22 167 Fax: +90 222 320 4520 Emails: udemiray@anadolu.edu.tr or udemiray33@gmail.com URL: Http://www.ugurdemiray.com.tr Http://tojde.anadolu.edu.tr

  8. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-10-01

    investigated attitudes toward using the Internet as a learning tool among students at Bangkok University; students’ expectation of social networks and search engines in learning English, as well as their perceived usefulness. It also examined their use of the Internet for learning English. The samples were 198 undergraduate students enrolled in Fundamental English course at Bangkok University. The instrument in this study was a questionnaire. Results from the study indicated that the levels of attitudes toward using the Internet as a learning tool and Internet use for learning English in general were moderate. To receive further information and to send your recommendations and remarks, or to submit articles for consideration, please contact TOJDE Secretariat at the below address or e-mail us to tojde@anadolu.edu.tr Hope to stay in touch and meet in our next Issue, on 1st of January 2014 Cordially, Prof. Dr. Ugur Demiray Editor-in-Chief Anadolu University Yunusemre Campus 26470 Eskisehir TURKEY Tel: +90 222 335 0581 begin_of_the_skype_highlighting +90 222 335 0581 ÜCRETSİZ end_of_the_skype_highlighting ext. 5262 GSM: +90 542 23 22 167 or Fax: +90 222 320 4520 or Emails: udemiray@anadolu.edu.tr or udemiray33@gmail.com URL: http://home.anadolu.edu.tr/~udemiray URL: http://tojde.anadolu.edu.tr

  9. DNAAlignEditor: DNA alignment editor tool

    Directory of Open Access Journals (Sweden)

    Guill Katherine E

    2008-03-01

    Full Text Available Abstract Background With advances in DNA re-sequencing methods and Next-Generation parallel sequencing approaches, there has been a large increase in genomic efforts to define and analyze the sequence variability present among individuals within a species. For very polymorphic species such as maize, this has lead to a need for intuitive, user-friendly software that aids the biologist, often with naïve programming capability, in tracking, editing, displaying, and exporting multiple individual sequence alignments. To fill this need we have developed a novel DNA alignment editor. Results We have generated a nucleotide sequence alignment editor (DNAAlignEditor that provides an intuitive, user-friendly interface for manual editing of multiple sequence alignments with functions for input, editing, and output of sequence alignments. The color-coding of nucleotide identity and the display of associated quality score aids in the manual alignment editing process. DNAAlignEditor works as a client/server tool having two main components: a relational database that collects the processed alignments and a user interface connected to database through universal data access connectivity drivers. DNAAlignEditor can be used either as a stand-alone application or as a network application with multiple users concurrently connected. Conclusion We anticipate that this software will be of general interest to biologists and population genetics in editing DNA sequence alignments and analyzing natural sequence variation regardless of species, and will be particularly useful for manual alignment editing of sequences in species with high levels of polymorphism.

  10. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

    Directory of Open Access Journals (Sweden)

    Alan L Jiao

    Full Text Available As the founding member of the microRNA (miRNA gene family, insights into lin-4 regulation and function have laid a conceptual foundation for countless miRNA-related studies that followed. We previously showed that a transcriptional lin-4 reporter in C. elegans was positively regulated by a lin-4-complementary element (LCE, and by lin-4 itself. In this study, we sought to (1 identify additional factors required for lin-4 reporter expression, and (2 validate the endogenous relevance of a potential positive autoregulatory mechanism of lin-4 expression. We report that all four core nuclear RNAi factors (nrde-1, nrde-2, nrde-3 and nrde-4, positively regulate lin-4 reporter expression. In contrast, endogenous lin-4 levels were largely unaffected in nrde-2;nrde-3 mutants. Further, an endogenous LCE deletion generated by CRISPR-Cas9 revealed that the LCE was also not necessary for the activity of the endogenous lin-4 promoter. Finally, mutations in mature lin-4 did not reduce primary lin-4 transcript levels. Taken together, these data indicate that under growth conditions that reveal effects at the transgenic locus, a direct, positive autoregulatory mechanism of lin-4 expression does not occur in the context of the endogenous lin-4 locus.

  11. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

    Science.gov (United States)

    Jiao, Alan L; Foster, Daniel J; Dixon, Julia; Slack, Frank J

    2018-01-01

    As the founding member of the microRNA (miRNA) gene family, insights into lin-4 regulation and function have laid a conceptual foundation for countless miRNA-related studies that followed. We previously showed that a transcriptional lin-4 reporter in C. elegans was positively regulated by a lin-4-complementary element (LCE), and by lin-4 itself. In this study, we sought to (1) identify additional factors required for lin-4 reporter expression, and (2) validate the endogenous relevance of a potential positive autoregulatory mechanism of lin-4 expression. We report that all four core nuclear RNAi factors (nrde-1, nrde-2, nrde-3 and nrde-4), positively regulate lin-4 reporter expression. In contrast, endogenous lin-4 levels were largely unaffected in nrde-2;nrde-3 mutants. Further, an endogenous LCE deletion generated by CRISPR-Cas9 revealed that the LCE was also not necessary for the activity of the endogenous lin-4 promoter. Finally, mutations in mature lin-4 did not reduce primary lin-4 transcript levels. Taken together, these data indicate that under growth conditions that reveal effects at the transgenic locus, a direct, positive autoregulatory mechanism of lin-4 expression does not occur in the context of the endogenous lin-4 locus.

  12. From the Editor

    OpenAIRE

    Ugur Demiray

    2011-01-01

    Turkish Online Journal of Distance Education-TOJDE April 2011 ISSN 1302-6488 Volume: 12 Number: 2 from EditorGreetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 12, Number: 2. In this issue it is published 4 notes for Editor, 14 articles, 1 book review. And this time, 43 authors from 10 different countries are placed. These published articles are from Austrlia, Bangldesh, India, lndonasia, Iran, Malaysia. Pakistan, Serbia, Turkey and USA.The first Notes for editor a...

  13. ISTP CDF Skeleton Editor

    Science.gov (United States)

    Chimiak, Reine; Harris, Bernard; Williams, Phillip

    2013-01-01

    Basic Common Data Format (CDF) tools (e.g., cdfedit) provide no specific support for creating International Solar-Terrestrial Physics/Space Physics Data Facility (ISTP/SPDF) standard files. While it is possible for someone who is familiar with the ISTP/SPDF metadata guidelines to create compliant files using just the basic tools, the process is error-prone and unreasonable for someone without ISTP/SPDF expertise. The key problem is the lack of a tool with specific support for creating files that comply with the ISTP/SPDF guidelines. There are basic CDF tools such as cdfedit and skeletoncdf for creating CDF files, but these have no specific support for creating ISTP/ SPDF compliant files. The SPDF ISTP CDF skeleton editor is a cross-platform, Java-based GUI editor program that allows someone with only a basic understanding of the ISTP/SPDF guidelines to easily create compliant files. The editor is a simple graphical user interface (GUI) application for creating and editing ISTP/SPDF guideline-compliant skeleton CDF files. The SPDF ISTP CDF skeleton editor consists of the following components: A swing-based Java GUI program, JavaHelp-based manual/ tutorial, Image/Icon files, and HTML Web page for distribution. The editor is available as a traditional Java desktop application as well as a Java Network Launching Protocol (JNLP) application. Once started, it functions like a typical Java GUI file editor application for creating/editing application-unique files.

  14. In vitro expansion of Lin+ and Lin- mononuclear cells from human peripheral blood

    Science.gov (United States)

    Norhaiza, H. Siti; Rohaya, M. A. W.; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul

    2013-11-01

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin-) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin+) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin- cell population. The ability of Lin+ and Lin- to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin+ and Lin- were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin+ mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin- stem cells were not able to survive in proliferation medium however, addition of cytokines into the proliferation medium support Lin

  15. Lin28a regulates germ cell pool size and fertility

    Science.gov (United States)

    Shinoda, Gen; de Soysa, T. Yvanka; Seligson, Marc T.; Yabuuchi, Akiko; Fujiwara, Yuko; Huang, Pei Yi; Hagan, John P.; Gregory, Richard I.; Moss, Eric G.; Daley, George Q.

    2013-01-01

    Overexpression of LIN28A is associated with human germ cell tumors and promotes primordial germ cell (PGC) development from embryonic stem cells in vitro and in chimeric mice. Knockdown of Lin28a inhibits PGC development in vitro, but how constitutional Lin28a deficiency affects the mammalian reproductive system in vivo remains unknown. Here, we generated Lin28a knockout (KO) mice and found that Lin28a deficiency compromises the size of the germ cell pool in both males and females by affecting PGC proliferation during embryogenesis. Interestingly however, in Lin28a KO males the germ cell pool partially recovers during postnatal expansion, while fertility remains impaired in both males and females mated to wild type mice. Embryonic overexpression of let-7, a microRNA negatively regulated by Lin28a, reduces the germ cell pool, corroborating the role of the Lin28a/let-7 axis in regulating the germ lineage. PMID:23378032

  16. From the Editor

    OpenAIRE

    Ugur Demiray

    2009-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 10, Number: 2. This is the second issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published four notes for Editor, 13 articles, 2 reviews. And this time, 28 authors from 8 different countries are placed. These published articles are from Canada, Gana, India, Iran, Malaysia, Pakistan, United Kingdom and Turkey. “Reflective Approach In Teaching Pre-Degree Chemistry” has sent to editor of TOJ...

  17. From the Editor

    OpenAIRE

    Ugur Demiray

    2012-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 13 Number: 1 In this issue it is published 5 notes for Editor, 16articles, 2 books reviews a nd this time, 53 authors from 12 different countries are placed. These published articles are from Azerbaijan, Bangladesh, Greece, Iran, Malaysia, Morocco, Nigeria, Pakistan, Turkey, UAE and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Simply including a narrative co...

  18. From the Editor

    OpenAIRE

    Ugur Demiray

    2011-01-01

    Dear readers of TOJDE,TOJDE appears on your screen now as Volume 12, Number: 4. In this issue it publishes 5 notes for Editor, 10 articles, 2 book reviews. And this time, 33 authors from 10 different countries are placed. These published articles are from Bangladesh, Ethiopia, India, Malaysia, Nigeria, Pakistan, Saudi Arabia, Turkey, UAE and USA. The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Google+ is like Twitter in that anyone can follo...

  19. From the editors

    NARCIS (Netherlands)

    NN,

    2001-01-01

    Hofstadter’s Law: Things always take longer than you think, even when you take into account Hofstadter’s Law. [D. Hofstadter, Gödel, Escher, Bach: an eternal golden braid (1980) 152]. This certainly applies to the forthcoming issues of the Flora Malesiana. According to its editors the bottleneck

  20. Letters to the Editor

    Science.gov (United States)

    1999-09-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents The imaginary Sun? Harold Aspden Energy Science Ltd, PO Box 35, Southampton SO16 7RB, UK Difficult physics? Tim Akrill Chief Examiner, A-level Physics, Edexcel Foundation Was it a dream? Bill Jarvis 6 Peggy's Mill Road, Edinburgh EH4 6JY

  1. From the editor's desk

    Indian Academy of Sciences (India)

    Ever since the Indian Academy of Sciences inherited the publication of the Journal of Genetics from J. B. S. Haldane, successive Editors-in-Chief, Profs H. Sharat Chandra, K. VijayRaghavan, Amitabh Joshi and Rajiva Raman, with the support of members of the editorial board, have not only sustained but also expanded the ...

  2. Letter to the editors

    African Journals Online (AJOL)

    2012-10-19

    Oct 19, 2012 ... (interleukin 10 (IL10), Tumor necrosis factor alpha (TNF- alpha) and interferon gamma (IFN-gamma) were done. ... 2. To the editors of the Pan African Medical Journal. Rheumatic heart disease (RHD) is a devastating squeal of acute rheumatic fever (ARF) in Africa. .... Gorgulu S, Eren M, Bagirtan B et al.

  3. Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Paul Boshears

    2012-08-01

    Full Text Available With grateful hearts we offer this, the second issue of our second volume. The result of months of back-breaking thinking, emailing, looking, clicking, watching, writing and reading, our summer issue is here. The editors could not have done this without your support. We welcome your materials for our future issues as well as your continued contributions.

  4. Letter from the Editors

    Directory of Open Access Journals (Sweden)

    The Editors

    2013-07-01

    Full Text Available With grateful hearts we offer this, the first issue of our third volume. The result of months of back-breaking thinking, emailing, looking, clicking, watching, writing and reading, our new issue is here. The editors could not have done this without your support. We welcome your materials for our future issues as well as your continued contributions.

  5. Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Paul Boshears

    2012-11-01

    Full Text Available With grateful hearts we offer this, the third issue of our second volume. The result of months of back-breaking thinking, emailing, looking, clicking, watching, writing and reading, our fall issue is here. The editors could not have done this without your support. We welcome your materials for our future issues as well as your continued contributions.

  6. Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Jamie Allen

    2013-05-01

    Full Text Available With grateful hearts we offer this, the fourth issue of our second volume. The result of months of back-breaking thinking, emailing, looking, clicking, watching, writing and reading, our winter issue is here. The editors could not have done this without your support. We welcome your materials for our future issues as well as your continued contributions. Purchase your copy of our first book from Punctum Books.

  7. DOSSIER: Intelectuales y Editores

    Directory of Open Access Journals (Sweden)

    Gustavo Sorá

    2009-04-01

    Full Text Available El intelectual abre ideas, el editor las cierra. El escritor produce textos, el editor impresos. El intelectualescribe pero es el editor quien publica. No por nada, afirman algunos psicólogos, el pensamientoculmina con su publicación. Entre el escritor y el editor se moviliza una energía simbólica y socialsublimada bajo las líneas impresas que llegan al lector. Ese entre-lugar de producción de sentidos, decosmologías, de sociedad que marcó la formación de gran parte de las culturas desde la aparición de laexpresión gráfica de las ideas, permanece como un problema esquivo para la investigación, al menospara la antropología practicada en estas latitudes. Parece una cuestión obturada por el dominanteacúmulo de historias de las ideas, de la literatura, del pensamiento que reactualizan la oposición entreespíritu y materia, estética y sociedad, texto y contexto. Evidencia de ello es la clausura sufrida por lasociología de la literatura, una sub-disciplina tan incómoda para los guardianes del aura del genioliterario nacional.Este dossier busca iluminar esa relación con la certeza de que modela uno de los terrenos másfértiles para repensar el legado de la historia de la cultura en occidente y para generar un basto programade problemas de investigación escasamente explorados por las ciencias sociales y humanas en AméricaLatina, y aplicables al estudio de toda cultura, con o sin escritura.

  8. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2007-04-01

    Full Text Available I am pleased to inform you that in the 8th year of TOJDE are appeared on your screen now as Volume 8, Number: 2. In this issue we published one notes for Editor, 14 articles, two reviews, news and announcements for our readers. 27 authors from ten different countries are placed in this issue. These published articles are from Australia, Bahrain, Bangladesh; Canada Indonesia, Malaysia, Pakistan, Turkey, UK and USA.

  9. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2004-04-01

    Full Text Available Turkish Online Journal of Distance Education-TOJDE April 2004 ISSN 1302-6488 Volume:5 Number:2 -------------------------------------------------------------------------------- From the Editor I am pleased to inform you that Vol.:5, Number:2 issue of The Turkish Online Journal of Distance Education-TOJDE has been issued on the web site http://tojde.anadolu.edu.tr now. TOJDE is meeting with its readers for the 14th time, since 2000 January.First of all I would like to inform you once more that Volume 5 Number:3 will publish as a special theme issue of TOJDE. This issue will be prepare by Patrick Alan DANAHER, Fons NOUWENS, from Learning, Evaluation, Innovation and Development (LEID Centre, within the Division of Teaching and Learning Services, at Central Queensland University (CQU in Australia and Zeynep ERDINC from Anadolu University as a guest co-editors. Call for papers for taht issue finished at 15th March. Now, the selected articles are in reviewing and evaluation phase in process. In this issue, has been given place to two note for editor, eight articles, three book reviews, 9 news, and as being before three links deal with Anadolu University take place in the literature and introducing a journal dealt with DE application. This issue's articles came from Canada, Greece, Turkey and USA (according to alphabetical order.

  10. From The Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-01-01

    Full Text Available Dear TOJDE Readers, Welcome to the Volume 14 Number: 1 of TOJDE! In this issue, 31 articles of 65 authors from 12 different countries around the world have been published. These published articles are arrived to the TOJDE from Australia, Guyana, India, Indonesia, Iran, Malaysia, Nigeria, Russia, Taiwan, Turkey, USA and Zimba bwe. First all, you should know that if a submission picks up from three TOJDE editors between 4.5 and 9 over all 9 credits, it means that this submission can be published in TOJDE in the coming issue. However, since the publishing priority of the accepted papers belongs to the highest scored ones, submissions which receive a score between 4.5 and 5 or 6 may wait and be archived for publishing later on. TOJDE administration respected this publishing rule up to now. Therefore, some accepted submissions which obtained over 4.5 have not been published up to now. Some of these submissions were waiting for publishing in TOJDE in the future sice 2011. In this issue, we decided to give them a chance to be published. For this reason that becoming end of the year of 2012, more papers for this issue included me than the previous issues. The 1st article arrived from Nigeria and written by Sunday O. ADEGBESAN, from Training and Research Fellow, National Institute for Educational Planning and Administration (NIEPA, on “Effect Of Principals’ Leadership Style On Teachers’ Attitude To Work In Ogun State Secondary Schools, Nigeria ". The purpose of this study was to investigate why some principals prefer to embrace certain leadership styles and the effect of such styles on the teachers’ attitude to work. In the 2nd article is mentioned in their context, especially web-based learning comes forward. Web-based learning can be defined as an information technology-enabled and supported form of distance learning in which the traditional restrictions of classroom learning have disappeared. The Internet can be a useful aid in teaching

  11. EDITORIAL: Editor's Farewell

    Science.gov (United States)

    Hudson, R. P.

    1989-01-01

    The completion of Volume 26, 1989, marked the end of my tenure as Editor of Metrologia. My association with the journal, its parent body the Comité International des Poids et Mesures, its host organization the Bureau International des Poids et Mesures, the publishers Springer-Verlag and last (but by no means least) the Editorial Board, has been a pleasant one and I trust that the subscribers will have found the product to be generally satisfactory. There have been, it is true, some disappointments along the way and I shall mention two of these while expressing the hope that the new Editor will enjoy a greater success in their regard. First is the question of circulation, which has stayed dangerously low, although the shrinkage has tapered off in the most recent years. Because of the narrow public support, the costs of production are relatively high and this, through a consequently high subscription rate, tends to enshrine the unsatisfactory state of affairs. Modest schemes to broaden the journal's appeal and bring in a wider readership have foundered upon the first step, namely, that of procuring from staff members of the national standards laboratories the hoped-for articles which would discuss the state of the art in delivering the highest-quality measurement services to the public. However, some very interesting and bolder schemes are presently under discussion. I had also hoped to leaven the journal's content a little by regularly appearing articles on the latest developments within the great national laboratories. But, as with technical review articles, it has proven very difficult to find the right authors who can also spare the time, and only a few laboratories have found it possible to collaborate. In taking my leave, it remains for me to thank all the contributors, referees and readers for their support, to express the hope of an ever brighter future for Metrologia and to wish to the new Editor, Dr D A Blackburn, a happy and successful tenure.

  12. From the Editors

    Directory of Open Access Journals (Sweden)

    Sibel Sakarya Yucel Demiral

    2017-04-01

    Full Text Available Prof. Ray W. Guillery, English Editor of our Journal has passed away… Prof. Guillery (Greifswald-Germany; 1929 is a British physiologist and neuroanatomist. He began his education as a medical student at University College London (UCL. He obtained his BSc and his PhD in Anatomy. Guillery taught at UCL for 11 years. He helped to start the new graduate program in neuroscience in several Universities. In 1989, Guillery was the founding editor-in-chief of the European Journal of Neuroscience. He was Honorary Emeritus Research Fellow at the Anatomical Neuropharmacology Unit at Oxford since 2010.Prof R Guillery joined Turkish Journal of Public Health family with the second issue of 2008 and since then he worked with us for English edition of 24 issues voluntarily;  always in time and with a unique care. He would not only correct English grammar mistakes in manuscripts; but provide significant contribution by indicating unclear points as an interested reader; despite public health was not his area. During time, he developed interest to several public health issues and discussed with us. Ray was not only good in words but numbers; he would detect calculation mistakes in the manuscripts which were missed by reviewers and/or editors. Prof Ray Guillery conducted a course on Scientific Writing in English during National Public Health Congress which was held in Bursa. He has been always keen and generous in sharing his knowledge and experience. He never stopped his works in neuroscience and anatomy and completed his last book a few weeks before passing away.A big loss for scientific world and for our Journal. We express our appreciation for his contribution to our Journal and to all of us. Sibel Sakarya, Yücel Demiral 

  13. Analysis list: lin-13 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available lin-13 Embryo,Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/...lin-13.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/lin-13.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/target/lin-13.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-13.Embryo....tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-13.Larvae.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Embryo.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

  14. From the Editor

    OpenAIRE

    Ugur Demiray

    2006-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 3. Very much thanks to all of you once more that we met with you 23rd time, since January 2000. In this issue we published one notes for Editor 15 articles like in this issue, three book reviews, news and announcements for our readers. 25 authors from eight different countries are pleaced in this issue. These published articles are from...

  15. From the Editor

    OpenAIRE

    Ugur Demiray

    2006-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 4. Very much thanks to all of you and TOJDE editorial members once more that we managed to publish TOJDE 25th time, since January 2000. In this issue we published one notes for Editor, 13 articles, two reviews, news and announcements for our readers. 20 authors from seven different countries are placed in this issue. These published articles are from Ba...

  16. From The Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Readers, Welcome to the Volume 14 Number: 1 of TOJDE! In this issue, 31 articles of 65 authors from 12 different countries around the world have been published. These published articles are arrived to the TOJDE from Australia, Guyana, India, Indonesia, Iran, Malaysia, Nigeria, Russia, Taiwan, Turkey, USA and Zimba bwe. First all, you should know that if a submission picks up from three TOJDE editors between 4.5 and 9 over all 9 credits, it means that this submission can be publish...

  17. From the Editor

    OpenAIRE

    Ugur Demiray

    2009-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 10, Number: 4. This is the last issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published 3 notes for Editor, 13 articles, 4 book reviews. And this time, 33 authors from 13 different countries are placed. These published articles are from Bangladesh, Egypt, India, Iran, KKTC, Lesotho, Lithuania, Malaysia, Pakistan, Romania, United Kingdom, USA and Turkey.“iPhones and Smartphones” has sent ...

  18. Candice Lin: paisaje, territorio y fronteras (Candice Lin: Landscape, Territory and Boundaries

    Directory of Open Access Journals (Sweden)

    Gabriel Baltodano Román

    2017-11-01

    Full Text Available Se analizan los contenidos ideológicos de la acuarela «Nacimiento de una nación» (2008, de Candice Lin. A partir de nociones como territorio, tropo caníbal, tipo botánico tropical y pensamiento fronterizo, se plantea una interpretación de esa paisajística pictórica, en que la artista-activista reflexiona sobre el régimen de representación visual. Mediante diversos procedimientos formales, Lin pone en entredicho preceptos centrales de la mentalidad colonialista, que contrapone a las concepciones indigenistas. Abstract An analysis is provided of the ideological contents of the watercolor “Birth of a Nation” (2008, by Candice Lin. This interpretation of this pictorial landscape is based on notions such as territory, cannibal tropes, tropical botanical types and border thinking. The artist activist reflects here on the regime of visual representation. Using different formal procedures, Lin questions central precepts of the colonialist mentality, in contrast with indigenous conceptions.

  19. A CDL written intercom editor

    International Nuclear Information System (INIS)

    Marinescu, D.S.; Shirikov, V.P.

    1977-01-01

    This report contains the formalized description of the program EDITOR which is the most important part of the teleprocessing system INTERCOM driving terminals for CDC series 6000 and CYBER computers. CDL (Compiler Description language) is used for this description. EDITOR is a tool for the text file acquisition and modifications. It also gives the possibility to execute some commands to the computer software. The EDITOR independent description may be used for the implementation of EDITOR-like programmes for different types of computers (is particular, small computers)

  20. From the Editors

    Directory of Open Access Journals (Sweden)

    Sibel Sakarya

    2017-09-01

    Full Text Available From the Editors Dear readers,We are happy to greet you with the August 2017 issue of our Journal. This issue contains two reports and five original articles. The title of the first report is “Roma Health in Edirne: Social Determinants of Health and Health Status”. In their report, Eskiocak et al. investigate the social determinants of health and their health related outcomes among the Roma communities living in Edirne. The second report deals with gender related issues. Doğan et al. investigate the effects of gender inequality on women's lives through a comparison of countries that do and do not implement policies based on gender equality.Original articles in this issue cover many important public health issues. The first, conducted by Koçak et al., investigates the type 2 diabetes risk of primary school teachers and their lifestyle behaviors. Results of the study show that 5.7% out of 975 primary school teachers have a high risk of type 2 diabetes.The second original article entitled “Unintended pregnancies, induced abortions and risk factors in women admitted to hospitals due to birth or abortion in Hatay” was based on a study of 635 women. The results of this study, done by Savaş et al., show an unintended pregnancy rate of 15%. It is further estimated that almost half of all induced abortions are reported as spontaneous abortions. The third article, which was written by Çam et al., is about the frequency of eating disorders in adolescents. This descriptive study, with the participation of 338 high school students, found the frequency of eating disorder attitudes to be 18.3% among the participants. In a descriptive study conducted by Emerce et al., the knowledge and practice of laboratory safety by laboratory analysts and technicians was investigated. It was found that all 93 laboratory workers who participated in the study have failed in some safety practices throughout their careers, and have been eager to get regular

  1. Carta del Editor

    OpenAIRE

    Luis Eladio Proaño

    2015-01-01

    Henos aquí con un nuevo número de RIESED. Después de casi un año de ver la luz, y como lo anticipábamos en la carta del editor que acompañaba al número fundacional, hacer una revista electrónica no ha sido una tarea sencilla. Un año más tarde no podemos sino confirmar esa opinión.Gracias al decidido trabajo de los autores, revisores y miembros del equipo editorial hemos podido hacerlo. El proceso de revisión de los artículos ha merecido un cuidado, dedicación y tiempo especiales, que hicieron...

  2. From the Editors

    Directory of Open Access Journals (Sweden)

    Jason Harshman

    2016-11-01

    Full Text Available Teaching about globalizations and our interconnectedness with people and places around the world is an essential component of K-12 and higher education, but knowledge about global issues and news is not enough. Increased mobility, digital communication, and cultural hybridity, along with oppression and social injustice require that educators and students not only be able to communicate and collaborate with people different from them, but regularly engage in critical self-reflection around perceived norms and values. In January 2016, the editors of this special issue distributed a call for theoretical, research-based, and practitioner oriented manuscripts on teaching and learning that bring social studies and global citizenship education together. Evidence by the transnational contributions published within this issue of the Journal of Social Studies Education Research, the place of global citizenship education within the social studies is evolving, multifaceted, and not without complications. In short: just how it should be.

  3. Letter from the editor

    Directory of Open Access Journals (Sweden)

    Germán A. Prieto G.

    2017-07-01

    Full Text Available On September 2017, two large earthquakes struck México. Numerous casualties and at least 40 buildings collapsed in Mexico City.   The earthquakes are explained by the tectonic setting of Central America, the Cocos plate subducts underneath the North American Plate at about 7-8 cm a year, making Mexico a seismically active region. But the two earthquakes - with hypocenter depths between 50 and 60 km – did not occur in the contact between the two tectonic plates as is usually expected, but rather within the Cocos plate as it bends downward within the mantle. Both events showed a normal faulting mechanism, and although they were widely felt, their major impact was in densely populated Mexico City, where wave amplification is expected due to the geological features of the City's soil structure.   We know that we cannot predict earthquakes, and although this is the holy-grail in seismology, it seems like we are not close to accurately predict them. Nevertheless, early warning systems have been developed in various places, including Mexico, and they were successful in issuing an alarm, although with a few seconds before the strong shaking. These developments can save lives and continue to be relevant and are likely to be implemented in other regions, including the pacific coast of the US. Another aspect that can save lives is people’s awareness. The M7.1 earthquake occurred in the afternoon of the anniversary of the 1985 Michoacan earthquake, just a couple of hours after an earthquake drill in Mexico City, so people had just recently been remained of what to do.  This most likely saved lives.   We should ask ourselves, are we prepared? Is our city prepared?     Germán Prieto Editor in Chief   Carlos A. Vargas Former Editor

  4. Message from the Editor

    Science.gov (United States)

    Stambaugh, Ronald D.

    2014-01-01

    This last year being an odd numbered year, the pages of Nuclear Fusion saw a large influx of expanded papers from the 2012 Fusion Energy Conference in San Diego. Many papers have focused on the scientific and technical challenges posed by ITER. Contributions are steadily increasing from the new superconducting tokamaks in Asia. The ITER Project continues to move ahead. Construction at the Cadarache site is quite remarkable. Buildings completed include the huge Poloidal Field Coils Winding Facility and the Headquarters building, which has been occupied by the ITER staff. Work is progressing on the Assembly building and the Cryostat Workshop. The base of the tokamak complex is being laid. Besides the construction that is taking place and will take place at the site, components from around the world have to navigate the complex route from Marseilles to the site. A test convoy replicating the dimensions and weights of the most exceptional ITER loads successfully traversed that route in 2013. We are pleased to report that the IAEA and ITER have finalized the agreement for ITER authors to publish papers in Nuclear Fusion . Nuclear Fusion is proud to continue its key role in providing the leading forum for the documentation of scientific progress and exchange of research results internationally toward fusion energy. Refereeing The Nuclear Fusion editorial office appreciates greatly the effort made by our referees to sustain the high quality of the journal. Since January 2005, we have been offering the most active referees over the past year a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in previous years. The following people have been selected: J.M. Canik, Oak Ridge National Laboratory, USA I.T. Chapman, Culham Centre for Fusion Energy, UK L.-G. Eriksson, Commission of the European Communities, Belgium T. Evans

  5. The Lin28/let-7 Axis Regulates Glucose Metabolism

    NARCIS (Netherlands)

    Zhu, Hao; Shyh-Chang, Ng; Segre, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G.; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

    2011-01-01

    The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating-metabolism. When overexpressed in mice, both

  6. GUEST EDITORS' INTRODUCTION: Guest Editors' introduction

    Science.gov (United States)

    Coulson, Geoff; de Meer, Jan B.

    1997-03-01

    . Their scheme is embedded in an experimental ATM network with the potential for guaranteed QoS. The system features QoS support mechanisms in both the network and the end systems. Of particular interest is reported experience with a dynamic QoS adaptation protocol implemented in the network and based on video scaling techniques and filtering. In summary, this special issue provides an up to date review of approaches to QoS management and their practical realization. Of course, no claim is made as to comprehensiveness, but the chosen papers do serve as a highly representative sample of current directions in QoS research. The editors are very much obliged to all authors, reviewers and publishers. Without their excellent work, and the contribution of their valuable time this special issue would not have been possible.

  7. Analysis list: lin-35 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available lin-35 Adult,Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/l...in-35.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/lin-35.5.tsv http://dbarchive.bioscienced...bc.jp/kyushu-u/ce10/target/lin-35.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-35.Adult.t...sv,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-35.Larvae.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Adult.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

  8. Greetings from the Editor

    Directory of Open Access Journals (Sweden)

    Mohammad Hosein Ebrahimzadeh

    2014-09-01

    Full Text Available It is my great honor announcing the promotion of the Archives of Bone and Joint Surgery (ABJS to the level of being available on the PubMed Central site. Being precise, one year ago in September 2013, we published the first issue of the ABJS. Diligently thereafter, we published four subsequent issues with the fifth being in front of you. We set this as our first goal to reach visibility on PubMed striving to raise the quality. We greatly hope that the orthopedics science may be exalted by this voluntary contribution. Hereby, I would like to specially thank to Sarah Post Calhoun and Wayne Jack Logue, from NLM/PMC, for their continuous support, giving direction, and cooperation. I am grateful to my colleagues, Dr Amir Reza Kachooei; the Managing Editor, Dr Ali Moradi; the Editorial Manager and Saeideh Erfani; the Administrative Staff  for their endeavor and being compassionate in this path. I also would like to thank Dr Farshid Bagheri, Dr Ali Birjandinejad, Dr Farzad Omidi-Kashani and Dr Mohsen Mardani-Kivi;  the Deputy Editors  whose continuous efforts from early 2013 has brought the journal to appreciation of scientific excellence.  My sincere thanks to all Editorial Board members and reviewers, who have contributed towards the excellence of the journal by putting efforts and expending their valuable time to evaluate the submitted manuscripts. I send my special thanks to Iranian Knee Surgery Arthroscopy & Sports Traumatology (ISKAST, Iranian Orthopedic Association (IOA, Iranian Society of Shoulder and Elbow Surgeons, and Deputy of Research at Mashhad University of Medical Sciences for their supports. I would like to thank the prime industry sponsers, Osveh Asia Medical Instrument Co. and Tehran Sutures Co. (Zimmer Distributer in Iran, for their financial support. Again I would like to appreciate all contributing authors particularly my outstanding colleagues who wrote an Editorial for us, Prof. Jupiter from Harvard University, Boston, MA

  9. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2014-06-01

    Full Text Available Dear authors, readers and future authors,it is my pleasure to present you the 1st number of the 38th volume of the Journal of Information and Organizational Sciences – JIOS.Please allow me one personal note. This is my last issue as an editor. I started in 2008. and it is time to make some changes. I’ll continue to act as a member of editorial board but I am handling over my editorial duty to new editor Alen Lovrenčić. It was pleasure to work with all authors, reviewers and collaborators and please continue partnership with JIOS because we have high aims which cannot be achieved without dedicated scientific community. I would also like to thank the publishing team of JIOS who helped with many operational issues especially: Bernarda Kos, Goran Hajdin and Darko Grabar. In this issue a selection of 3 original scientific papers, 1 survey paper and 1 preliminary communications has been included, all of which have undergone a rigorous double-blind review process in some cases in several rounds.The constant mission of JIOS is to cover scientific publications from broad area of information sciences and related disciplines and we continuously receive many articles in which authors strive to achieve scientific merit. Our review procedure is very strict but even when we decline papers we try to encourage authors in their future work and motivate them to give better results. That is why we maintain very good relations with our authors and we invite all of you to extend cooperation with JIOS.We hope that the variety of themes will draw the attention of researchers in different fields of information sciences and motivate potential authors to expand the Journal’s thematic scope by other themes that may be of interest to the wider ICT research community. These themes motivate us to continue our work of delivering research results to interested audience. The ICT field is changing rapidly and we are constantly searching for cutting edge articles that open

  10. From the Editor

    Directory of Open Access Journals (Sweden)

    Senar, J. C.

    2014-12-01

    Full Text Available In 2001, the Natural History Museum of Barcelona remodelled its journal Miscel·lània Zoològica as Animal Biodiversity and Conservation. One of the aims of this change was to obtain an impact factor, the index that characterises the international ranking of journals. This milestone was reached some years later, in 2012, having published 291 articles that have been cited in impact journals 1,626 times. Two of these papers have been cited more than 100 times. We are now ready to take the next step forward. Our new challenge is to increase our impact factor so that Animal Biodiversity and Conservation is comparable with prestigious international journals in the field. To meet this objective we have assembled a team of editors with international recognition, and we will continue to expand this team over time. We have sought support from the most prestigious Spanish scientific societies and three have accepted the task: the Spanish Society of Ethology, the Spanish Association of Terrestrial Ecology, and the Spanish Society of Evolutionary Biology. These societies have named thematic editors who will help us strengthen their respective disciplines. This means that we will also expand the range of fields covered in the journal in future, interpreting the expression animal biodiversity in the journal´s title in its widest sense. Another front that we have opened to boost Animal Biodiversity and Conservation is the new webpage, remodelled for use as a medium to post our published papers. With this move we not only hope to improve our services to readers but also look towards open access, open access in its broadest conception, offering the journal to scientists, both readers and authors, free of charge. If we want science and the knowledge it generates —produced with public money— to belong to us all, we not only have to enable everyone to read it but we also have to help everyone publish, independently of their economic state. These are difficult

  11. Letter from the Editor

    Directory of Open Access Journals (Sweden)

    Germán A. Prieto

    2018-01-01

    Full Text Available Letter from the editor Our first issue of 2018 is available now. We have 9 articles in this issue, in topics ranging from soil characterization, petrophysical properties of rocks, signal processing of images and GNSS station to asteroid impact effects. Mechanical soil properties in sandy-pebble soil are studied as a function of grain size content in Lu et al. Satellite-derived soil moisture estimation is discussed in Thanabalan and Vidhya, based on a semi-empirical approach and backscattering images. Macroscopic mechanical characteristics of rocks depend on a number of factors, including microstructure damage. Under changing temperature conditions (freeze-thaw rock samples studied by Jiang show significant strength decrease, which has important consequences in engineering. Advanced signal processing methods are used in Zeng et al. for image retrieval applied to remote sensing data, using a Bayesian network approach. Similarly, Oktar and Erdogan use linear trend and wavelet analysis to continuous GNSS data showing both displacements due to tectonic as well as atmospheric and hydrologic effects. Debris flows can in some cases become serious hazards because they can block river flow as a debris flow dam. Chen et al. propose a method to identify the formation of such dams, with an example from the Er river in Taiwan. Mamaseni et al. study the petrophysical properties of three formations in the Duhok Basin, northern Iran, based on well-log data. Results suggest a significant thickness with good moveable hydrocarbons in the study area. Methane adsorption and gas content are strongly influenced by shale composition. Zhu et al. show that Total Organic Content has a stronger influence on methane adsorption and gas content than the mineral composition, studying samples from the southern Sichuan Basin. Our last contribution in this issue discussed a large asteroid impact in eastern Colombia. The impact would have affected the environment and landscape, but

  12. Letter from the Editor

    Science.gov (United States)

    Strassmeier, Klaus G.

    2009-01-01

    As of 2007, Astronomische Nachrichten -- Astronomical Notes has reached its all-time high regarding the ISI journal impact factor, with an impressive increase of 60% compared to 2005. We now rank at 1,461, as shown in the statistics below. This is solely due to the increased quality of the published articles: In 2006, Astronomische Nachrichten -- Astronomical Notes published 208 research papers and received 1,033 citations -- five citations per paper on average. In 2007, we have published 177 research papers with roughly the same number of citations. In co-operation with Wiley InterScience we have achieved an average online publication time of just 4.5 months. We hope that the year 2008 will be comparably prosperous. As in the past, publication in Astronomische Nachrichten -- Astronomical Notes continues to be free of charge. Also, all articles of the first issue of each volume can be downloaded free of charge, as can all articles labelled ``Editor's Choice'', which are additionally featured with a color image on the front cover.

  13. The Lin28/let-7 axis regulates glucose metabolism

    Science.gov (United States)

    Zhu, Hao; Shyh-Chang, Ng; Segrè, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

    2012-01-01

    SUMMARY The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by blocking let-7 biogenesis. In studies of the Lin28/let-7 pathway, we discovered unexpected roles in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promoted an insulin-sensitized state that resisted high fat diet-induced diabetes, whereas muscle-specific loss of Lin28a and overexpression of let-7 resulted in insulin resistance and impaired glucose tolerance. These phenomena occurred in part through let-7-mediated repression of multiple components of the insulin-PI3K-mTOR pathway, including IGF1R, INSR, and IRS2. The mTOR inhibitor rapamycin abrogated the enhanced glucose uptake and insulin-sensitivity conferred by Lin28a in vitro and in vivo. In addition, we found that let-7 targets were enriched for genes that contain SNPs associated with type 2 diabetes and fasting glucose in human genome-wide association studies. These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism. PMID:21962509

  14. Using Lin's method to solve Bykov's problems

    Science.gov (United States)

    Knobloch, Jürgen; Lamb, Jeroen S. W.; Webster, Kevin N.

    2014-10-01

    We consider nonwandering dynamics near heteroclinic cycles between two hyperbolic equilibria. The constituting heteroclinic connections are assumed to be such that one of them is transverse and isolated. Such heteroclinic cycles are associated with the termination of a branch of homoclinic solutions, and called T-points in this context. We study codimension-two T-points and their unfoldings in Rn. In our consideration we distinguish between cases with real and complex leading eigenvalues of the equilibria. In doing so we establish Lin's method as a unified approach to (re)gain and extend results of Bykov's seminal studies and related works. To a large extent our approach reduces the study to the discussion of intersections of lines and spirals in the plane. Case (RR): Under open conditions on the eigenvalues, there exist open sets in parameter space for which there exist periodic orbits close to the heteroclinic cycle. In addition, there exist two one-parameter families of homoclinic orbits to each of the saddle points p1 and p2.See Theorem 2.1 and Proposition 2.2 for precise statements and Fig. 2 for bifurcation diagrams. Cases (RC) and (CC): At the bifurcation point μ=0 and for each N≥2, there exists an invariant set S0N close to the heteroclinic cycle on which the first return map is topologically conjugated to a full shift on N symbols. For any fixed N≥2, the invariant set SμN persists for |μ| sufficiently small.In addition, there exist infinitely many transversal and non-transversal heteroclinic orbits connecting the saddle points p1 and p2 in a neighbourhood of μ=0, as well as infinitely many one-parameter families of homoclinic orbits to each of the saddle points.For full statements of the results see Theorem 2.3 and Propositions 2.4, 2.5 and Fig. 3 for bifurcation diagrams. The dynamics near T-points has been studied previously by Bykov [6-10], Glendinning and Sparrow [20], Kokubu [27,28] and Labouriau and Rodrigues [30,31,38]. See also the surveys

  15. Carta del editor

    Directory of Open Access Journals (Sweden)

    Oscar Mauricio Covarrubias-Moreno

    2014-05-01

    Full Text Available Henos aquí con un nuevo número de RIESED. Después de casi un año de ver la luz, y como lo anticipábamos en la carta del editor que acompañaba al número fundacional, hacer una revista electrónica no ha sido una tarea sencilla. Un año más tarde no podemos sino confirmar esa opinión.Gracias al decidido trabajo de los autores, revisores y miembros del equipo editorial hemos podido hacerlo. El proceso de revisión de los artículos ha merecido un cuidado, dedicación y tiempo especiales, que hicieron necesario demorar unos días la fecha de publicación de este tercer número. Asumimos un compromiso con la calidad y estamos convencidos que esa es la única posibilidad de éxito para una revista científica. El contenido y nivel de los artículos disponibles servirá sin duda como incentivo para que los investigadores deseen publicar sus aportes en RIESED.Agradezco especialmente a la Dra. Gloria Rosique Cedillo, Editora Invitada y Coordinadora de este tercer número, así como al investigador César Nicandro Cruz-Rubio, Editor Asociado, apreciados colegas con quienes he tenido el privilegio de trabajar a lo largo de estos meses, y cuya dedicación y esmero han hecho posible RIESED 3.Por otra parte, derivado de nuestro proyecto editorial informo a ustedes de la creación de la Cátedra RIESED. Educación y Sociedad. Esta Cátedra es una iniciativa que la Universidad del Desarrollo Empresarial y Pedagógico ha impulsado en estrecha colaboración con el Grupo de Investigación en Gobierno Administración y Políticas Públicas (GIGAPP del Instituto Universitario de Investigación Ortega y Gasset (IUIOG, Fundación Ortega – Marañón; así como, con la Academia Internacional de Ciencias Político Administrativas y Estudios de Futuro A.C.La Cátedra está concebida como un espacio de diálogo y reflexión interdisciplinario sobre las diferentes temáticas abordadas en RIESED. En el marco de esta iniciativa académica, se invita a los miembros

  16. In vitro expansion of Lin{sup +} and Lin{sup −} mononuclear cells from human peripheral blood

    Energy Technology Data Exchange (ETDEWEB)

    Norhaiza, H. Siti; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul [School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Selangor (Malaysia); Rohaya, M. A. W. [Department of Orthodontics, Faculty of Dentistry, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur (Malaysia)

    2013-11-27

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin{sup −}) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin{sup +}) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin{sup −} cell population. The ability of Lin{sup +} and Lin{sup −} to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin{sup +} and Lin{sup −} were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin{sup +} mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin{sup −} stem cells were not able to survive in proliferation medium however

  17. Selective blockade of microRNA processing by Lin-28

    Science.gov (United States)

    Viswanathan, Srinivas R.; Daley, George Q.; Gregory, Richard I.

    2012-01-01

    MicroRNAs (miRNAs) play critical roles in development, and dysregulation of miRNA expression has been observed in human malignancies. Recent evidence suggests that the processing of several primary miRNA transcripts (pri-miRNAs) is blocked post-transcriptionally in embryonic stem (ES) cells, embryonal carcinoma (EC) cells, and primary tumors. Here we show that Lin-28, a developmentally regulated RNA-binding protein, selectively blocks the processing of pri-let-7 miRNAs in embryonic cells. Using in vitro and in vivo studies, we demonstrate that Lin-28 is necessary and sufficient for blocking Microprocessor-mediated cleavage of pri-let-7 miRNAs. Our results identify Lin-28 as a negative regulator of miRNA biogenesis and suggest that Lin-28 may play a central role in blocking miRNA-mediated differentiation in stem cells and certain cancers. PMID:18292307

  18. Editor's Comment and Announcement.

    Science.gov (United States)

    Bortolussi, Robert

    2017-12-17

    It is hard to believe but Clinical and Investigative Medicine (CIM), the official journal of Canadian Society for Clinical Investigation (CSCI), will soon celebrate its 40th birthday!  Over these past four decades, CIM has been the premier journal for Canadian clinician scientists; publishing over 1,000 articles on breakthroughs and major advances from Canada and around the world.  We are listed on Medline, PubMed and the Library of Science. We have been, and will continue to be, an independent journal. To celebrate this auspicious occasion, we have plans to become an even bigger showpiece for national and international clinical advances. We want to connect more closely with Canadian clinician scientists and trainees and we particularly want to encourage more Canadian publications. Changes will soon be coming to CIM with several new features: Newsletter with announcements and news on activities of interest to clinician scientists and trainees; Focused Reviews on specific areas of research; Reflections on work and life experiences of trainees and senior clinician scientists; Methods Papers describing novel methods anticipated to be useful for others; and  Guidelines or Recommendations on clinical care that are endorsed by a Canadian Medical or Surgical Society. Starting in 2018, we will be publishing on a quarterly basis. This will help to ensure we will focus on important breakthroughs and commentaries. However, we are also planning a special edition in the autumn to commemorate the 40th birthday. Stay tuned! Of course CIM will continue to publish original papers on discoveries in pathophysiology, prevention, management, treatment and outcome of clinical problems confronting clinicians in Canada and around the world.  Please join us as we embark on these changes and a new era for CIM, Robert Bortolussi Clinical and Investigative Medicine (CIM) Editor in Chief.

  19. From the Editor

    Directory of Open Access Journals (Sweden)

    Željko Hutinski

    2012-07-01

    Full Text Available All the papers in this issue of the JIOS Journal may fit into the Science as Usual categoryand are therefore not going to be dealt with in detail in the introduction. However, for oneof the papers included an exception has been provided, namely the paper Sigma-notationand the equivalence of P and NP classes by Miron Ivanovich Telpiz. The circumstancesleading to its publication in this issue of JIOS are presented by the editors in this preface.It is generally acknowledged that, ever since it was defined by S. Cook over thirty yearsago, P = NP has presented one of the major open problems in computing science andinformation science in general. Whereas, on one hand, this problem presents a formidablechallenge to any scientist dealing with it, its solution, especially in case it should turn out tobe a positive one considering that current technology tends to evolve in a practicaldirection and its overall functioning is conducted implicitly under the assumption of anegative solution would have a major impact on the development of informationtechnology as well as the wider context of human society as a whole. Apart from being putforward in conferences, both positive and negative “solutions” to P = NP problem can beoccasionally found in press, scientific and professional journals. The web page titled “Pversus-NP Page” (see http://www.win.tue.nl/~gwoegi/P-versus-NP.htm provides anexcellent source for this issue. It contains links to papers stating that P = NP, as well asthose contradicting the opposite, i.e., stating that P NP. Furthermore, references are givento Oded Goldreich's rationale behind his decision not to review papers proposing solutionsto P = NP problem and related difficult problems because, in his own words, they “alsoattract the attention of non-experts, and one annoying consequence is a flood of falseclaims of resolutions of these problems” (see http://www.wisdom.weizmann.ac.il/~oded/faq.html. Dr. Goldreich a recognised

  20. Lin28 sustains early renal progenitors and induces Wilms tumor

    Science.gov (United States)

    Urbach, Achia; Yermalovich, Alena; Zhang, Jin; Spina, Catherine S.; Zhu, Hao; Perez-Atayde, Antonio R.; Shukrun, Rachel; Charlton, Jocelyn; Sebire, Neil; Mifsud, William; Dekel, Benjamin; Pritchard-Jones, Kathy; Daley, George Q.

    2014-01-01

    Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differentiation, ultimately resulting in a pathology highly reminiscent of Wilms tumor. Using lineage-specific promoters to target Lin28 to specific cell types, we observed Wilms tumor only when Lin28 is aberrantly expressed in multiple derivatives of the intermediate mesoderm, implicating the cell of origin as a multipotential renal progenitor. We show that withdrawal of Lin28 expression reverts tumorigenesis and markedly expands the numbers of glomerulus-like structures and that tumor formation is suppressed by enforced expression of Let-7 microRNA. Finally, we demonstrate overexpression of the LIN28B paralog in a significant percentage of human Wilms tumor. Our data thus implicate the Lin28/Let-7 pathway in kidney development and tumorigenesis. PMID:24732380

  1. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2009-04-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 10, Number: 2. This is the second issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published four notes for Editor, 13 articles, 2 reviews. And this time, 28 authors from 8 different countries are placed. These published articles are from Canada, Gana, India, Iran, Malaysia, Pakistan, United Kingdom and Turkey. “Reflective Approach In Teaching Pre-Degree Chemistry” has sent to editor of TOJDE from India and written by B. Venkateswara RAO and D. Samrajya LAKSHMI from Andhra Pradesh University, Their paper involve an investigation of a chemistry teacher in two years intermediate education in Vijayawada, Andhra Pradesh, India. The teacher was successful in his goal of teaching for understanding because he was effective classroom manager and he had strong science content knowledge that enabled him to focus on instructional strategies that facilitated student understanding. He asked appropriate questions, responded to student questions, and used effective cognitive monitoring strategies. The teacher was able to teach effectively because he had adequate content knowledge and pedagogical content knowledge. The second notes for editor is titled as Study Of Learning Styles And Their Roles In The Academic Achievement Of The Students Of Payame Noor University (PNU” which is written by Mahdi Moeni KIA, Ahmad ALIAPOUR and Esmaeil GHADERI, from Human college, Payame Noor University, Tehran, IRAN. Their paper mentioned that most of male students use verbal and solitary learning styles. Most of female student use aural and verbal learning styles. The academic achievement of female students is more than the academic achievement of male students. Among the students of Payame Noor University, those who use visual learning style have the greatest achievement. Students with social, aural, verbal, and solitary learning styles are in the following ranks

  2. FROM THE EDITOR

    Directory of Open Access Journals (Sweden)

    Cemil Ozturk

    2014-10-01

    ısı” (Social Studies Teachers’ Perceptions of Tolerance and Feryal Çubukçu “Values Education Through Literary Texts”. These valuable papers have potential to contribute the literature on social studies education. One of the main aims of ASSE was to establish a regular scientific event through which social studies educators from Turkey and abroad get together to share their academic works and ideas. In conjunction with the Faculty of Education of Bolu Abant Izzet Baysal University we are organizing the Fourth International Symposium on Social Studies Education (ISSE in April 2015. The main theme of ISSE the 4th is “Peace Education”. The preference of this theme emphasizes on our hopes and determination for our envision for peace in the late Ottoman geography, in which guns have still been on fire and people have still been shedding tears. And this could be regarded as something similar to the action of Mustafa Kemal Pasha who thought of about the reconstruction of the country after the war and assembled an “Educational Congress” in Ankara to discuss educational issues, during the most difficult days of the War of Independence in 1921. Adopting this approach, we have been considering putting effort to institutionalize the values of democracy, human rights, justice, freedom of thought and freedom of conscience. As a final remark, I would like to thank everyone who contributed to the production of this issue and special thanks to Assoc. Prof. Dr. Erkan Dinç who acted as issue editor. Best regards and hope to meet you in ISSE the 4th…

  3. From the Guest Editor

    Directory of Open Access Journals (Sweden)

    Milun Babić

    2010-01-01

    ordinary, but I would like to use this occasion to emphasize that for successful development and international appearance of the Serbian researchers in the area of thermal science, energy and energy efficiency science we owe a lot to Professor Simeon Oka, Ph. D. (chief and executive editor of the journal Thermal Science and professor Milan Radovanović, Ph. D. (president of the Society of Thermal Engineers of Serbia. Gratitude that we have is not only for their effort as researchers and creative and challenging education, but also for the founding and guidance of Thermal Science, today internationally known and appreciated science journal. This long term editing work that professor Oka and professor Radovanović nurse within the Society of Thermal Engineers of Serbia became window to world for Serbian researchers. Publishing the scientific article in the journal Thermal Science today is not only the major research event for domestic scientists but for the researchers all over the world. About excellent science and nurture characters of professor Oka and professor Radovanović is saying a lot the decision to dedicate this special issue of the journal Thermal Science to fifty anniversary of Faculty of Mechanical Engineering in Kragujevac. This decision was greeted by the employees of MFKG as a special and dear acknowledgment for their effort during fifty years long research work.

  4. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2011-10-01

    Full Text Available Dear readers of TOJDE,TOJDE appears on your screen now as Volume 12, Number: 4. In this issue it publishes 5 notes for Editor, 10 articles, 2 book reviews. And this time, 33 authors from 10 different countries are placed. These published articles are from Bangladesh, Ethiopia, India, Malaysia, Nigeria, Pakistan, Saudi Arabia, Turkey, UAE and USA. The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Google+ is like Twitter in that anyone can follow a given user‘s posts. There is no direct ―friend‖ relationship required to read the posts written by others. However, it also approximates some features of Facebook. Rather than friends sorted into ―lists‖ like in Facebook, Google+ allows users to place feeds into one or more ―circles,‖ the better to monitor (or control the flow of information to and from different audiences. Circles are more intuitive, and more central to the experience, than the Facebook lists. They provide an explicit organizational structure, compared to the less-obvious listing functionality, which feels like an afterthought, found in Facebook. The second notes for editor is titled as ―Learning Community In Online Education‖ which is written by Ziad D. BAGHDADI, Faculty, Riyadh Colleges of Dentistry & Pharmacy, Riyadh, SAUDI ARABIA, Faculty, Damascus University Dental Faculty, Damascus, SYRIA. This paper discusses establishing learning communities early in online education and their helps in bridging distances and differences between physical and virtual worlds of teaching and learning. This article sheds light on the importance of learning communities, and gives readers advices for creating communities that connect, engage, and inspire. Several tools for assessment of learning are provided to appraise online learning communities‘ benefits to learners at all levels. ―Investigating The Effect Of Asynchronous Discussions On Students‘ Learning And Understanding Of

  5. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2011-04-01

    Full Text Available Turkish Online Journal of Distance Education-TOJDE April 2011 ISSN 1302-6488 Volume: 12 Number: 2 from EditorGreetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 12, Number: 2. In this issue it is published 4 notes for Editor, 14 articles, 1 book review. And this time, 43 authors from 10 different countries are placed. These published articles are from Austrlia, Bangldesh, India, lndonasia, Iran, Malaysia. Pakistan, Serbia, Turkey and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Google Moderator and Other Clicker Alternatives. In their notes they mentioned that Students register the device on the company Web site, and the instructor synchronizes the database in order to know which students have registered devices, thus creating accountability for “quizzes” in class. During the lecture, students “vote” for multiple choice answers on screen, and real-time results are displayed (anonymously after the polling is finished, providing instant formative feedback. Another model is for a department or institution to purchase clickers and make available in the classroom. Students pick up the clicker as they enter the room each day and replace when exiting. Using this approach does not allow for direct accountability, unless students are registered to a specific number on the clicker, which is documented and tracked. The second notes for editor is titled as “The Effect Of Virtual Versus Traditional Learning In Achieving Competency-Based Skills” which is written by Leili MOSALANEJAD, Sakine SHAHSAVARI and Mehdi DASTPAK from IRAN. In this quasi-experimental study, 86 freshman nursing students were recruited. Nursing Fundamentals and Skills (including theoretical and practical credits was decided as the teaching course. The theory and practical contents were taught in one group by conventional method (face to face teaching, demonstration on moulage and for another

  6. Lin's theory of flux and nuclear reactions

    International Nuclear Information System (INIS)

    Ping-Wha Lin

    2002-01-01

    Mathematical development of Lin's theory of flux is presented. Based on the Theory, when a chemical reaction system is subjected to a high time rate of temperature change, it changes from equilibrium to non-equilibrium conditions. It is proved mathematically that, when a gas system is subjected to a high time rate of temperature increase, the activities of particles (molecules, atoms or nuclei, and electrons) are increased: the particles are accelerated; frequencies and amplitudes of electron and atomic vibrations in a molecule increased; average kinetic energy of the particles increased; atomic bonds are ruptured; electrons are caused to leave their orbits. If most or all of the electrons leave their orbits, the gas fluid becomes plasma, which is very active chemically. The acceleration of nuclei in the dynamic condition can lead to nuclear reactions. In the pilot plant studies conducted at Research Triangle, NC, USA, for SO 2 conversion to SO 3 by rapid heating, a 10-ft high vertically fired combustor (VFC) was used. Air containing 0.5% SO 2 is forced continuously through the VFC, where it is heated by burners for conversion of SO 2 to SO 3 . During the idle period of operation, no external heat is added to the system by turning off the burners. It is observed that, as the air passing through the VFC during the idle period of sixteen hours, the temperature of the flowing air consistently rises up rapidly from ambient temperature (90 deg F) at inlet of the VFC to an average temperature as high as 582 deg F (in the range of 840 deg F to 455 deg F) at one section of the VFC, an increase of about 500 deg F. The air flow temperature increase of such large magnitude and long duration clearly indicates that nuclear reactions are present in VFC. It is also found that the water vapour in the air stream has completely disappeared in the VFC, for no sulphuric acid formation resulting from the reaction of water and SO 3 is detected there. Presumably, the water vapour in the

  7. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur demiray

    2008-04-01

    Full Text Available Greetings Dear readers of TOJDE, TOJDE is appeared on your screen now as Volume 9, Number: 2. This is the second issue of the year 2008. In this issue we published 5 notes for Editor, 12 articles, already … reviews and this time 27 authors from twelve different countries are placed. These published articles are from Canada, Bangladesh, Egypt, Ethiopia, Nigeria, Norway, Pakistan, Philippines, South Africa, The United Kingdom, USA and Turkey. “Reflections on screenagers, faculty development and net-supported learning” has been sent from Norway and written by Mike K. MOULTON for Notes for Editor section. He mentioned in his material that strategy for a faculty development program with respect to net-supported learning. Many universities and colleges are struggling with meeting the demands of a rapidly changing world. His reflections are based on experiences from the Norwegian University of Life Sciences. The Second paper has been sent from South Africa, written by Professor Dele Braimoh which is titled as “lifelong learning through mentoring process and its operational dimensions in society”. His paper analyses the varying dimensions of mentoring phenomenon which may be characterized by flexibility of learning process among different groups of people in any given society. He conclude that mentoring is a useful informal and longlife educational process which is not only cost effective, but can also stimulate personal development, increase productivity and improve performance. The third paper on “Development and Validation Process Of A European Language Portfolio Model For Young Learners”, sent by Dr. Ismail Hakki MIRICI from Turkey. He gave a place that various models are being or will be developed and validated in Council of Europe member States depending on the age of learners and national contexts including ELPs for higher and adult education developed by a number of international NGOs. Similarly, every member state should organize

  8. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2005-09-01

    Full Text Available Greetings Dear readers of TOJDE,I am pleased to inform you that Volume 6, Number: 4 are appearing on your screen now as which is addressed http://tojde.anadolu.edu.tr. Very much thanks to all of you once more that we met 19th time, since January 2000. As we announced in Volume: 6 Number: 3-4 issue, April 2006 issue of TOJDE would published on special issue is to indicate foresight, innovation, and strategy for the future direction of e-learning, more than web-oriented teaching and multipoint videoconferencing, for collaborative, distributed, experiential learning and creation of new knowledge, with youngsters around the world, which hence promote mutual understanding for global peace. Emphasis will be on knowledgeable and inspiring papers (but not limited on the use of GRID networking technology with distributed computer simulation for experiential (hands-on learning through broadband Internet, across national, continental and oceanic boundaries. Subjects are in any fields of e-learning and e-healthcare/telemedicine, in research, case studies, project descriptions, implementation, and reports from the field or book review. I would like to announce for all you, that Volume: 7 Number: 2 will publish as the 4th Special Theme Issue of TOJDE in April 2006. This issue will be prepare by Guest Editor Takeshi UTSUMI, Ph.D., P. E. (Founder and V. P. for Technology and Coordination of Global University System (GUS, USA and Guest Co-Editor Associate Professor Piet KOMMERS (from University of Twente, The Netherlands. In this issue we published 13 articles, three reviews, some news and announcements for our readers. The first article is coming from USA. Author is one of our recent authors; his name is Dr. Scott L. WALKER. This time he wrote on “Modifying Formative Evaluation Techniques For Distance Education Class Evaluation” subject. He indicates in his article that “Post-secondary classes are usually followed by mandatory summative evaluations, yet

  9. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2009-10-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 10, Number: 4. This is the last issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published 3 notes for Editor, 13 articles, 4 book reviews. And this time, 33 authors from 13 different countries are placed. These published articles are from Bangladesh, Egypt, India, Iran, KKTC, Lesotho, Lithuania, Malaysia, Pakistan, Romania, United Kingdom, USA and Turkey.“iPhones and Smartphones” has sent to editor of TOJDE from, USA and written by Kevin YEE & Jace HARGIS from University of the Pacific, California. Their paper involve that the iPhone has become a juggernaut in the United States, with 13 million units sold in 2008 (a 245% increase over 2007 and a further 45 million units expected in 2009 (Elmer-DeWitt, 2009. While iPhone still lags Nokia and RIM internationally, the overall trend toward mobile computing becomes firmer by the day, and it behooves educators to become familiar with the cell phone tools that are relevant for teaching in tomorrow’s -and increasingly “today’s”- classroom.The second notes for editor is titled as “Indian School Teachers’ Perspective On Globalisation of Education A Case Study of Atomic Energy Education Society School Teachers ” which is written by Dr. M. RAJESH and SINDHU. P. NAIR, from Indira Gandhi National Open University. They mentioned in their paper that globalisation has become an enduring reality of our times and more so in the field of education. Teachers are the harbingers of change in the global economy and school teachers have a major role in shaping the attitude of the society towards all social and economic phenomena including that of globalisation. At the Regional Centre of IGNOU situated at Cochin, Kerala an unique training programme was conducted for a year to train school teachers of the Atomic Energy Education Society (AEES one of the elite educational organisations of the country

  10. Message from the Editor

    Science.gov (United States)

    Stambaugh, Ronald D.

    2013-01-01

    reviewed five manuscripts in the period November 2011 to December 2012 and provided excellent advice to the authors. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in recent years. The following people have been selected: Marina Becoulet, CEA-Cadarache, France Jiaqui Dong, Southwestern Institute of Physics, China Emiliano Fable, Max-Planck-Institut für Plasmaphysik, Germany Ambrogio Fasoli, Ecole Polytechnique Federale de Lausanne, Switzerland Eric Fredrickson, Princeton Plasma Physics Laboratory, USA Manuel Garcia-Munoz, Max-Planck-Institut fuer Plasmaphysik, Germany William Heidbrink, California University, USA Katsumi Ida, National Inst. For Fusion Science, Japan Peter Stangeby, Toronto University, Canada James Strachan, Princeton Plasma Physics Laboratory, USA Victor Yavorskij, Ukraine National Academy of Sciences, Ukraine In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2012. Our thanks to them!

  11. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2006-07-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 3. Very much thanks to all of you once more that we met with you 23rd time, since January 2000. In this issue we published one notes for Editor 15 articles like in this issue, three book reviews, news and announcements for our readers. 25 authors from eight different countries are pleaced in this issue. These published articles are from Bangaldesh, Canada, India, Moldova, Nigeria, Uganda, South Africa, Turkey and USA.The learning organization concept is getting more important in our life day by day at any fields of professionalism, especially for education institution. In this millennium its impotency is increasing in the name of virtual learning environments too. In this issue I gave a place one Notes for Editor from Turkey, Anadolu University. It is written by Assoc. Prof. Dr. Deniz TASCI on the subject that “Online Learning Programs as Learning Organizations: A Case Study of Information Management Programs at Anadolu University, Turkey”. She indicates in her notes that the results of a study in which facilitators’ attitudes toward effectiveness of various media used in the Information Management Associate Degree Program (IMP of Open Education Faculty at Anadolu University, Turkey. The study has shown that textbooks are not viewed as efficient as multimedia programs and web environments by facilitators although they indicate that textbooks should still be used in online courses. The participants also found multimedia programs distributed on CDs more effective than the web environments. The first article of this issue is coming from National Open University of Nigeria, which is written by Olugbenga David OJO and Felix Kayode OLAKULEIN. Their article titled as “The Place of Multiple Intelligence in Achieving the Objectives and Goals of Open and Distance Learning Institutions: a critical analysis

  12. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2008-01-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 8th year of TOJDE finished and TOJDEis appeared on your screen now as Volume 9, Number: 1. This the first issue of the year 2008. As you know the volume 8 Number 3 was the special issue of TOJDE on “Web 2.0 and Social Software in Distance Education” subject. During 6 months I received more than 45 submissions. Some of them rejected by me for the reason that their subjects were not fit for TOJDE’s publishing content strategy and policy, and some of them rejected by TOJDE’s editors. And others can be publish this year’s issues In this issue we published one notes for Editor, 15 articles, already three reviews and this time 24 authors from ten different countries are placed in this issue. These published articles are from Austria, Bangladesh, Egypt, Greece, India, Iran, Jordan, Nigeria, Pakistan and Turkey. GET A SECOND CHANCE TO MAKE A FIRST IMPRESSION: Eradicate the Poverty Level of the Women Farmer in Bangladesh has been sent from Bangladesh Open University and written by Zobaida AKHTER, Ph.D. for Notes for Editor section. She mentioned in her material argues that efforts to promote women in farming are confronted by challenges including poverty, misconception regarding education, training, farming etc. The paper also states that the utilization and development of distance education would effectively address the problem of education and training aimed at rural women. The first article of this issue is coming from Vienna, AUSTRIA, Wegener Center for Climate and Global Change at Graz University, FH Joanneum Graz, and Federal Environment Agency written by Gilbert AHAMER on “Virtual Structures For Mutual Review Promote Understanding Of Opposed Standpoints” . Gilbert metion ih his paper that , in level 2 of SGC students write, review, assess and update standpoints while making use of a web based discussion forum. A statistical analysis of student activities is

  13. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2012-01-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 13 Number: 1 In this issue it is published 5 notes for Editor, 16articles, 2 books reviews a nd this time, 53 authors from 12 different countries are placed. These published articles are from Azerbaijan, Bangladesh, Greece, Iran, Malaysia, Morocco, Nigeria, Pakistan, Turkey, UAE and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Simply including a narrative component may provide enough creative ammunition for students to feel that a particular assignment can be more interesting (Clark 2010, if their work is to be wrapped around a narrative format, such as a short story in favor of an essay or formal writing. But there are numerous free technology tools available today that take the process one step further, by injecting different editing options and high-end production values. Students do not merely assemble a story in words. They can now do it primarily with images, and many of the slideshow services online allow for text captions, dynamic transitions, special effects, and relevant animations. Students become videographers and directors as much as they function as storytellers. The slideshow builders thus do a better job than “old fashioned” essay/short story assignments at meeting the need of 21st century students, many of whom arrive at institutions of higher learning with at least an already-ingrained interest in such tools, if not explicit experience.The following note is that a review of existing literature pertaining to servant leadership and faculty development. Specifically, this work discussed delivering servant leadership to online faculty through the utilization of a faculty development program. The idea for this literature review stemmed from the author asking how an online academic administrator could utilize the practice of servant leadership in order to improve the overall online academic

  14. Frof Guest Editors

    Directory of Open Access Journals (Sweden)

    Mark J. W. LEE

    2007-07-01

    the role of universities as content producers for credentialed learning to be questioned, prompting many educators to explore new ways of supporting online learning. The sixth article from Palitha Edirisingha (UK, Chiara Rizzi (Italy, Ming Nie (UK and Libby Rothwell (UK report on a study involving the use of podcasting (Curry, 2004 to provide teaching and learning support for an undergraduate module on English Language and Communication. The findings led to development of a model for integrating podcasts in on-campus blended learning, and which can have potential applications in distance learning contexts. The model is based on three main features of podcasts identified as facilitating student learning: learner choice and flexibility offered by podcasts; tacit knowledge and experience of peers conveyed in discussions; and a sense of informality brought into formal learning. Also from the implementation perspective, Penny de Byl and Janet Taylor (Australia describe a Web 2.0/Web3D hybrid e-learning platform, called the AliveX3D platform, which involves the application of the Web 2.0 ethos to an online 3D virtual environment. The platform and accompanying tools are designed to enable the creation of authentic learning experiences with a large degree of learner control, and to promote collaborative dialogue between learners. The immersion in the 3D worlds enables learners to negotiate meaning based on their own personal cognitive, affective and kinaesthetic experiences rather than relying merely on descriptions of others’ experiences. Last but not least, the “Notes to the Editor” section contains a contribution from Yavuz Akbulut and Mübin Kiyici (Turkey, on the instructional uses of blogs. And two book reviews from the field. We hope you enjoy reading this contributions, and welcome your feedback, rejoinders and reflections on the various articles contained within this special issue. Mark J. W. LEE and Hakan G. SENELGuest Editors, July 2007 Acknowledgements

  15. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur DEMIRAY

    2006-04-01

    the program. Therefore, more research on gender, attitude, and experience in such programs is needed to understand how students work with mathematical software programs and use them as learning tool in the class environment. Next article is from Bangladesh Open University, BANGALDESH, which written by Md. Tofazzal ISLAM from School of Agriculture and Rural Development, Morshedur RAHMAN and K. M. Rezanur RAHMAN from School of Science and Technology, Bangladesh Open University, which is titled as Quality And Processes Of Bangladesh Open University Course Materials Development“. Their paper, attempt to describe the processes and quality of BOU course materials development taking into account the strengths and weaknesses as well as possible ways of improvement. It is mentioned in their article that as a new member of the mega-Universities, Bangladesh Open University (BOU introduced with an example a course team approach for developing effective course materials for distance students. BOU teaching media includes such as printed course books, study guides, radio and television broadcasts, audiocassettes and occasional face-to-face tutorials. Each course team comprises specialist course writer(s, editor, trained style editor, graphic designer, illustrator, audio-visual producer and anonymous referees. An editorial board or preview committee is responsible for the final approval for publishing or broadcasting materials for learners. This approach has been proved to be effective, but appeared to be complicated and time-consuming. This report focuses on the quality and processes of BOU course materials development taking into account the strengths and weaknesses of the current approach. The thirteenth one about is “Economic Thought About Private Sector Education: Policy Implications for Management of Universities in Africa”, written by Joel B. BABALOLA from University of Ibadan, Ademola S. TAYO from Babcock University, A. OKERDIRAN from University of Ibadan, A. O. AYENI

  16. Medical Editors Trial Amnesty (META)

    African Journals Online (AJOL)

    may change jobs, with the result that important work remains unfinished; or investigators may discover a recently published trial on the same topic and conclude that their own results are now redundant. Editors must also take some responsibility. There is a limit to the number of reports we can publish and sometimes we are ...

  17. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur DEMIRAY

    2011-08-01

    , Bogazici University, Istanbul,TURKEY. This paper examines the emerging ideas to implement the usage of Second Life as an educational tool in a wide range of subject areas. The majority of the information used to create these 10 pedagogical approaches was derived from a series of participative inquiries, personal observations, formal and informal interviews, and documenting the perceptions of teachers and students using (and trying to use Second Life as an educational tool. Ten pedagogical approaches have emerged thus far. Each section briefing explains the concept, illustrates the idea with examples, and provides implementation suggestions. The sixth article from USA on “USE OF SECOND LIFE IN K-12 AND HIGHER EDUCATION: A Review of Research”, written by Chris INMAN, Vivian H. WRIGHT & Julia A. HARTMAN, from The University of Alabama, USA. This artile is published in Journal of Interactive Online Learning, Volume 9, Number 1, Spring, 2010 and republished by official permission of JIOL Editor-in-Chief’. This study reviewed empirical research conducted in Second Life by educators since Second Life’s launch in 2003. The study’s purpose was to identify how Second Life is being used in both K-12 and higher education. The methodology, findings, and recommendations of 27 research studies were analyzed. Researchers identified potential problems when using Second Life in education, including issues with the Second Life software and hardware requirements, a steep learning curve, and the possibility of students becoming exposed to distractions or inappropriate content. The seventh one is again from USA. On “GENOME ISLAND: A Virtual Science Environment in Second Life”, written by Mary ANNE CLARK, from Texas Wesleyan University, USA”. This article describes the organization and uses of Genome Island, a virtual laboratory complex constructed in Second Life. Genome Island was created for teaching genetics to university undergraduates but also provides a public space where

  18. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2006-10-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 4. Very much thanks to all of you and TOJDE editorial members once more that we managed to publish TOJDE 25th time, since January 2000. In this issue we published one notes for Editor, 13 articles, two reviews, news and announcements for our readers. 20 authors from seven different countries are placed in this issue. These published articles are from Bangladesh, Germany, Greece, India, Nigeria, South Korea and Turkey.In the “Notes for Editor” section, Dr KURT’s excutive summary is placed via title “Comparative Analysis f Virtual Education Applications”. Dr. Mehmet KURT from Ankara University, Department of Educational Sciences Program of Curriculum and Instruction TURKEY. This summary is his doctorate thesis which is completed on March 2006 at Ankara University. He emphasizes that while in the teaching process they use both synchronous and asynchronous presentation technologies; in order to support course content they use e-mail, web, cd, and course book technologies to provide basic learning environment function; they prefer different environments to cover face to face education needs; they take self learning and collaboration as basis and they take projects and term paper evaluations serious; they mostly prefer multiple choice tests and they usually make virtual courses exams through the internet. Regarding the characteristics of their institutions’ applications, the study group have agreed on mostly to connection and being dependent on connection opportunities. A significant difference between their institutions’ characteristics and the model for developing computer labs, when they had started to provide virtual lessons and presentation technologies used has been found.The first article of this issue is coming from Hellenic Open University, GREECE which is written by Paraskevi VASSALA. In

  19. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-10-01

    toward using the Internet as a learning tool among students at Bangkok University; students’ expectation of social networks and search engines in learning English, as well as their perceived usefulness. It also examined their use of the Internet for learning English. The samples were 198 undergraduate students enrolled in Fundamental English course at Bangkok University. The instrument in this study was a questionnaire. Results from the study indicated that the levels of attitudes toward using the Internet as a learning tool and Internet use for learning English in general were moderate To receive further information and to send your recommendations and remarks, or to submit articles for consideration, please contact TOJDE Secretariat at the below address or e-mail us to tojde@anadolu.edu.tr Hope to stay in touch and meet in our next Issue, on 1st of January 2014. Cordially, Prof. Dr. Ugur Demiray Editor-in-Chief Anadolu University Yunusemre Campus 2647 Eskisehir TURKEY Tel: +90 222 335 0581 begin_of_the_skype_highlighting +90 222 335 0581 ÜCRETSİZ end_of_the_skype_highlighting ext. 5262 GSM: +90 542 23 22 167 or Fax: +90 222 320 4520 or Emails: udemiray@anadolu.edu.tr or udemiray33@gmail.com URL: http://home.anadolu.edu.tr/~udemiray URL: http://tojde.anadolu.edu.tr

  20. Editorial: Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Wilhelm Heitmeyer

    2011-12-01

    Full Text Available This issue our guest editors are close to home. Wilhelm Heitmeyer and Steven F. Messner, both members of our own Board of Editors, have assembled a focus section examining the question of “Youth at Risk.” Their collection certainly lives up to our aspiration to be truly interdisciplinary and international. The methods applied in the reported research range from interview-based studies through empirical number-crunching to laboratory experiments (the latter a first for this journal; the geographical scope spans from Argentina through Central America and Europe to Africa. The youth at risk here are in conflict with the police, with each other, with societies that fear them, with societies that ignore their needs. Our systematically eclectic approach continues outside the focus section too, with contributions on the theory of violence, female fighters in Africa, and spousal violence in Pakistan.

  1. The graphics editor in ROOT

    International Nuclear Information System (INIS)

    Antcheva, Ilka; Brun, Rene; Hof, Carsten; Rademakers, Fons

    2006-01-01

    A well-designed Graphical User Interface (GUI) has critical importance in any computer application. The user interface is where the end users and the complex system intersect. An effective interface design can make a powerful and complex system, such as ROOT, easy and intuitive to learn and operate. This paper describes the main goals we defined and the design solution we found developing the graphics editor in ROOT

  2. New Editors Appointed for Water Resources Research

    Science.gov (United States)

    2009-03-01

    Praveen Kumar (University of Illinois at Urbana-Champaign), the newly appointed editor in chief of Water Resources Research (WRR), heads the new team of editors for the journal. The other editors are Tom Torgersen (University of Connecticut, Groton), who continues his editorship; Tissa Illangasekare (Colorado School of Mines, Golden); Graham Sander (Loughborough University, Loughborough, UK); and John Selker (Oregon State University, Corvallis). Hoshin Gupta (University of Arizona, Tucson) will join WRR at the end of 2009. The new editors will begin receiving submissions immediately. The incoming editorial board thanks outgoing editors Marc Parlange, Brian Berkowitz, Amilcare Porporato, and Scott Tyler, all of whom will assist during the transition.

  3. EDITORIAL: Message from the Editor Message from the Editor

    Science.gov (United States)

    Thomas, Paul

    2010-02-01

    November 2009 and provided particularly detailed advice to the authors. The other three have been very helpful in 'minority fields'. We have excluded our Board members, Guest Editors of special editions and those referees who were already listed in the last four years. Guest Editors' work on papers submitted to their Special Issues is also excluded from consideration. The following people have been selected: Tomonori Takizuka, JAEA-Naka Fusion Institute, Japan Rudolf Neu, Max-Planck-Institut für Plasmaphysik, Germany Sibylle Guenter, Max-Planck-Institut für Plasmaphysik, Germany Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States David R. Mikkelsen, Princeton Plasma Physics Laboratory, United States Peter C. de Vries, EURATOM/UKAEA Fusion Association, United Kingdom Yasuhiro Suzuki, National Institute for Fusion Science, Japan Jerzy Wolowski, Institute of Plasma Physics and Laser Microfusion, Poland Tetsuo Tanabe, Kyushu University, Japan Yasuyuki Yagi, National Institute of Advanced Industrial Science and Technology, Japan Congratulations and many, many thanks! The Guest Editors of special editions deserve a special mention for the excellent help that they have given us. They are: Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States, Special Issue on H-Mode Physics and Transport Barriers Yaroslav Kolesnichenko, Institute for Nuclear Research, Ukraine, Special Issue on Energetic Particles in Magnetic Confinement Systems Kimitaka Itoh, National Institute for Fusion Science, Japan and Howard R. Wilson, University of York, UK, Special Issue on Plasma Instabilities Bernhard Unterberg, Forschungszentrum Juelich, Germany, Special Issue on Stochastic Fusion Plasma In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2009. Our thanks to them! Authors The winner of the 2009 Nuclear Fusion

  4. Editorial: Letter from the Editors

    Directory of Open Access Journals (Sweden)

    James Sidanius

    2012-12-01

    Full Text Available This issue of the journal focuses on the question of bullying prevention, with a collection of articles put together by Manuel Eisner and Tina Malti. We are very grateful to them for the hard work they put in as focus section editors – and in their contributions to the section. The open section this time takes us to North America for a study of identity and in-group superiority and Africa for a review of the question of youth and violence.

  5. 93 une urbanisation linéaire, dynamique demographique et ...

    African Journals Online (AJOL)

    Mohand

    d'Alger, dans l'ensemble Sahel-Mitidja sur un linéaire côtier de 2 km. Rattaché administrativement à la daira de ... connait une dynamique démographique remar- quable, dans sa périphérie orientale - composé de l'ensemble Sahel-. Mitidja ..... «Etude agro-pédologique de la plaine de la Mitidja». Florin B.; Semoud N. 2010.

  6. régression linéaire multiple

    African Journals Online (AJOL)

    Mots clés: Alcools et phénols – Représentation numérique de la structure chimique – Facteur acentrique – Régression linéaire multiple – Modèle RSP hybride. English Title: Structure / acentric factor relationship of alcohols and phenols: genetic algorithm – multiple linear regression approach. English Abstract. The acentric ...

  7. A Dynamic Attitude Measurement System Based on LINS

    Directory of Open Access Journals (Sweden)

    Hanzhou Li

    2014-08-01

    Full Text Available A dynamic attitude measurement system (DAMS is developed based on a laser inertial navigation system (LINS. Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG. The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min.

  8. A Dynamic Attitude Measurement System Based on LINS

    Science.gov (United States)

    Li, Hanzhou; Pan, Quan; Wang, Xiaoxu; Zhang, Juanni; Li, Jiang; Jiang, Xiangjun

    2014-01-01

    A dynamic attitude measurement system (DAMS) is developed based on a laser inertial navigation system (LINS). Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR) filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG). The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ) and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min. PMID:25177802

  9. Thanks to outgoing Associate Editors

    Science.gov (United States)

    Lichti, Derek D.; Weng, Qihao

    2018-04-01

    As of the end of December 2017, Professors Eberhard Gülch, Olaf Hellwich, Minho Kim, and Lalit Kumar have retired as Associate Editors of the ISPRS Journal of Photogrammetry and Remote Sensing. Our Journal's readership has benefited greatly from their longstanding commitment to their editorial duties. Both Profs. Gülch and Hellwich began their service to the Journal in 2007, while Profs. Kumar and Kim began in 2012 and 2014, respectively. In their many years as editors, they have witnessed the incredible growth of the Journal in terms of the number of papers submitted and published as well as the impact factor. Thanks to their high standards for paper quality and rigorous peer review, these professors have been important contributors to the Journal's current high standing. They were very versatile in terms of the scope of papers they could handle. Eberhard handled papers in photogrammetry, terrain modelling and geographic information systems (GIS) while Olaf handled papers in radar, computer vision and GIS. Both Lalit and Minho handled papers in optical remote sensing. On behalf of the Journal and the International Society for Photogrammetry and Remote Sensing, we thank them for many years of dedicated service to the Journal.

  10. A new record editor for Invenio 3

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    On this presentation, a new record editor will be presented. Current version under development can be found in https://github.com/inveniosoftware-contrib/ng2-json-editor. This editor uses JSON as its native data format, provides many configuration options and can handle very large JSON documents. An update on the development status and pointers to how to use it in your own installation will be provided.

  11. Learning the vi and Vim Editor

    CERN Document Server

    Robbins, Arnold; Hannah, Elbert

    2008-01-01

    There's nothing that hard-core Unix and Linux users are more fanatical about than their text editor. Editors are the subject of adoration and worship, or of scorn and ridicule, depending upon whether the topic of discussion is your editor or someone else's. vi has been the standard editor for close to 30 years. Popular on Unix and Linux, it has a growing following on Windows systems, too. Most experienced system administrators cite vi as their tool of choice. And since 1986, this book has been the guide for vi. However, Unix systems are not what they were 30 years ago, and neither is this

  12. EDITORIAL: Message from the Editor Message from the Editor

    Science.gov (United States)

    Thomas, Paul

    2011-01-01

    As usual, being an even year, the 23rd IAEA Fusion Energy Conference took place at Daejeon, Korea. The event was notable not just for the quality of the presentations but also for the spectacular opening ceremony, in the presence of the Prime Minister, Kim Hwang-sik. The Prime Minister affirmed the importance of research into fusion energy research and pledged support for ITER. Such political visibility is good news, of course, but it brings with it the obligation to perform. Fortunately, good performance was much in evidence in the papers presented at the conference, of which a significant proportion contain 'ITER' in the title. Given this importance of ITER and the undertaking by the Nuclear Fusion journal to publish papers associated with Fusion Energy Conference presentations, the Nuclear Fusion Editorial Board has decided to adopt a simplified journal scope that encompasses technology papers more naturally. The scope is available from http://iopscience.iop.org/0029-5515/page/Journal%20information but is reproduced here for clarity: Nuclear Fusion publishes articles making significant advances to the field of controlled thermonuclear fusion. The journal scope includes: the production, heating and confinement of high temperature plasmas; the physical properties of such plasmas; the experimental or theoretical methods of exploring or explaining them; fusion reactor physics; reactor concepts; fusion technologies. The key to scope acceptability is now '....significant advances....' rather than any particular area of controlled thermonuclear fusion research. It is hoped that this will make scope decisions easier for the Nuclear Fusion office, the referees and the Editor.The Nuclear Fusion journal has continued to make an important contribution to the research programme and has maintained its position as the leading journal in the field. This is underlined by the fact that Nuclear Fusion has received an impact factor of 4.270, as listed in ISI's 2009 Science Citation

  13. lin-12 Notch functions in the adult nervous system of C. elegans

    Directory of Open Access Journals (Sweden)

    Tucey Tim M

    2005-07-01

    Full Text Available Abstract Background Notch signaling pathways are conserved across species and traditionally have been implicated in cell fate determination during embryonic development. Notch signaling components are also expressed postdevelopmentally in the brains of adult mice and Drosophila. Recent studies suggest that Notch signaling may play a role in the physiological, rather than developmental, regulation of neurons. Here, we investigate a new non-developmental role for Caenorhabditis elegans lin-12 Notch signaling in neurons regulating the spontaneous reversal rate during locomotion. Results The spontaneous reversal rate of C. elegans during normal locomotion is constant. Both lin-12 gain and loss of function mutant animals had significantly increased reversal rates compared to wild type controls. These defects were caused by lin-12 activity, because the loss of function defect could be rescued by a wild type lin-12 transgene. Furthermore, overexpression of lin-12 recapitulated the gain-of-function defect. Increasing or decreasing lin-12 activity in the postdevelopmental adult animal was sufficient to rapidly and reversibly increase reversals, thereby excluding a developmental role for lin-12. Although lin-12 is expressed in the vulval and somatic gonad lineages, we find that these tissues play no role in regulating reversal rates. In contrast, altering lin-12 activity specifically in the nervous system was sufficient to increase reversals. These behavioral changes require components of the canonical lin-12 signaling cascade, including the ligand lag-2 and the transcriptional effector lag-1. Finally, the C. elegans AMPA/kainate glutamate receptor homolog glr-1 shows strong genetic interactions with lin-12, suggesting that glr-1 and/or other glutamate gated channels may be targets of lin-12 regulation. Conclusion Our results demonstrate a neuronal role for lin-12 Notch in C. elegans and suggest that lin-12 acutely regulates neuronal physiology to

  14. Examining Editor-Author Ethics: Real-World Scenarios from Interviews with Three Journal Editors

    Science.gov (United States)

    Amare, Nicole; Manning, Alan

    2009-01-01

    Those who submit manuscripts to academic journals may benefit from a better understanding of how editors weigh ethics in their interactions with authors. In an attempt to ascertain and to understand editors' ethics, we interviewed 3 current academic journal editors of technical and/or business communication journals. We asked them about the…

  15. Editorial - Letter from the Editors

    Directory of Open Access Journals (Sweden)

    James Sidanius

    2009-12-01

    Full Text Available This time our focus section deals with the topic of ethnic and racial violence and conflict. We are grateful to our guest editors Robert D. Crutchfield (Universityof Washington, United States and Werner Bergmann (TU Berlin, Germany for putting together an appealing collection of contributions addressing this important field. As usual, our Open Section reflects the enormous breadth of our field, with articles on the theories of Clausewitz and the media’s treatment of rape incidents in kibbutzim.Aside from regular activities, the IJCV is in the process of migrating to a new content management system. From next year the journal will appear in a new online design and be easier to browse. The address will not change, though. If you have signed up for our news alerts you will receive further information in good time.

  16. EDITORIAL: Message from the Editor

    Science.gov (United States)

    Thomas, Paul

    2009-01-01

    Plasmaphysik, Germany) V. Philipps (Forschungszentrum Juelich, Germany) S. Zweben (Princeton Plasma Physics Laboratory, USA) Y. Hirano (National Institute of Advanced Industrial Science and Technology, Japan) Y. Takase (Tokyo University, Japan) In addition there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2008. Our thanks to them! Authors The winner of the 2007 award was Clemente Angioni for the paper entitled `Density response to central electron heating: theoretical investigations and experimental observations in ASDEX Upgrade' (Nucl. Fusion 44 8277-845). The winner of the 2008 Nuclear Fusion award is Todd Evans et al for the paper `Suppression of large edge localized modes with edge resonant magnetic fields in high confinement DIII-D plasmas' (Nucl. Fusion 45 595-607). The awards were presented by the IAEA Deputy Director General, Werner Burkart, and the Chairman of the Board of Editors, Mitsuru Kikuchi, on 16 October 2008 at the 22nd IAEA Fusion Energy Conference in Geneva, Switzerland. Given the topicality of these papers for the ITER design, it is a matter of pride to the journal that the work should be published in Nuclear Fusion. Reviews Like many who have worked for a long time in the field, I still make use of Nuclear Fusion Reviews that go back 20 or 30 years. It is particularly useful, therefore, that the Board of Editors has been working to re-activate the review programme. The first fruits will appear in this issue, in the form of `A review of zonal flow experiments', by Akihide Fujisawa. The special procedures for Reviews should be noted: most specifically that they should normally be commissioned by the Board of Editors. However, not only is the Board of Editors working on a programme but I am sure that they would be pleased to consider suggestions for review subjects. Letters The reputation of Nuclear

  17. Good editorial practice: editors as educators.

    Science.gov (United States)

    Marusić, M; Marusić, A

    2001-04-01

    There may be valuable research going on in the developing and financially less-privileged countries, but it usually does not reach international visibility, in spite of a large number of scientific journals in these countries. Such journals are not only invisible but, by perpetuating a vicious circle of inadequacy, may be directly damaging to the local science and research culture. We call for an international action to help journal editors in less privileged countries. International associations of editors may be leaders of these activities by defining, promoting, and perhaps controlling good editorial practice, as a main criterion for international recognition of a journal. However, the editors of small journals have the power and moral obligation to become a stronghold of quality and advancement in their scientific community. Their educational "tools" are editorial integrity and author-friendly policy. Editors can teach the authors study design, statistical analysis, precision, punctuality, research integrity, style and format of writing, and other aspects of scientific communication. The editors of "big", mainstream scientific journals can act as global educators, teaching and providing guidance to editors of small journals. The editors from developed countries as leaders, and editors from less advantageous environments as teachers are the key figures in shaping research communication in less privileged scientific communities.

  18. MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

    Science.gov (United States)

    Beckers, Anneleen; Van Peer, Gert; Carter, Daniel R.; Gartlgruber, Moritz; Herrmann, Carl; Agarwal, Saurabh; Helsmoortel, Hetty H.; Althoff, Kristina; Molenaar, Jan J.; Cheung, Belamy B.; Schulte, Johannes H.; Benoit, Yves; Shohet, Jason M.; Westermann, Frank; Marshall, Glenn M.; Vandesompele, Jo; De Preter, Katleen; Speleman, Frank

    2016-01-01

    LIN28B has been identified as an oncogene in various tumor entities, including neuroblastoma, a childhood cancer that originates from neural crest-derived cells, and is characterized by amplification of the MYCN oncogene. Recently, elevated LIN28B expression levels were shown to contribute to neuroblastoma tumorigenesis via let-7 dependent de-repression of MYCN. However, additional insight in the regulation of LIN28B in neuroblastoma is lacking. Therefore, we have performed a comprehensive analysis of the regulation of LIN28B in neuroblastoma, with a specific focus on the contribution of miRNAs. We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. First, through an unbiased LIN28B-3′UTR reporter screen, we found that miR-26a-5p and miR-26b-5p regulate LIN28B expression. Next, we demonstrated that MYCN indirectly affects the expression of miR-26a-5p, and hence regulates LIN28B, therefor establishing a MYCN-miR-26a-5p-LIN28B regulatory axis. Second, we provide evidence that MYCN regulates LIN28B expression via interaction with the LIN28B promotor, establishing a direct MYCN-LIN28B regulatory axis. We believe that these findings mark LIN28B as an important effector of the MYCN oncogenic phenotype and underlines the importance of MYCN-regulated miRNAs in establishing the MYCN-driven oncogenic process. PMID:26123663

  19. Refinements to calandria tube - liquid injection nozzle (CT-LIN) contact assessments

    International Nuclear Information System (INIS)

    Sedran, P.J.

    2012-01-01

    In recent years, the issue of CT-LIN contact, which first gained attention in 1989, has been addressed through CT-LIN gap measurements, followed by analytical predictions of time-to-contact. CT-LIN time-to-contact predictions have been preformed independently by CPUS Limited for Point Lepreau and Gentilly-2 and by AECL Sheridan Park (now Candu Energy Inc.) for Bruce Power and Gentilly-2. Both companies used the CDEPTH code in combination with CT-LIN gap measurements. Subsequent to the assessments for Point Lepreau and Gentilly-2, a recommended approach for future assessments was presented at the 2008 CANDU maintenance conference. Since that time, a number of refinements to the overall strategy for predicting CT-LIN time-to-contact have been developed and are outlined in this paper. The refinements include: 1. The use of ultrasonic LIN elevation measurements to confirm LIN creep sag behaviour 2. The development of a non-linear empirical CT Creep Sag Model 3. The development of a rationale for discrepancies observed in repeated optical CT-LIN gap measurements and a discussion of alternative CT-LIN gap measurements With these refinements, more accurate CT-LIN time-to-contact predictions can be obtained. For stations that plan to refurbish by 210,000 EFPH, the improvement in time-to-contact predictions resulting from the fore mentioned refinements will not be of any real benefit.. However, for stations that are planning life extensions in order to operate beyond 210,000 EFPH, CT-LIN contact will be an issue. For these stations, improvements in CT-LIN contact time predictions would be beneficial. This paper presents a summary of the proposed refinements and demonstrates how they would impact CT-LIN time-to-contact predictions. (author)

  20. Editorial: Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Andreas Zick

    2015-07-01

    Full Text Available Editorial 8(2 We are pleased to present issue 8 (2. The focus section is edited by Helmut Thome (University of Halle-Wittenberg, Germany and Steven F. Messner (University at Albany, United States, and focuses on methodological constraints, options, and solutions in longitudinal research on criminal violence. We are honored that Helmut Thome, Steven Messner, and the contributors offer their scientific knowledge and evidence in the interests of gaining a deeper understanding of one of the most promising methodological approaches in conflict and violence research, i.e. longitudinal data analyses. Sincere thanks to the editors and authors for opening up the potential of this specific kind of research for advances to better assess and understand criminal violence in a long term perspective. We hope this issue will be discussed and quoted in the interdisciplinary community of researchers. The open section again fulfills its aim to foster contributions on diverse topics in the field of conflict and violence, starting with an analysis of Southeast Asian media reception of the Israeli/Palestine conflict. The second paper shows how social cohesion activities have the potential to change disparaging attitudes in Cyprus. The third and final contribution examines teen dating violence in Switzerland from various angles.

  1. EDITORIAL: Letter from the Editor Letter from the Editor

    Science.gov (United States)

    Pashinin, Pavel P.

    2013-01-01

    Dear readers, contributors, and members of the world laser physics community. It is a great honour for us to introduce to you our new publishing partner, IOP Publishing, a subsidiary of the Institute of Physics, United Kingdom. IOP Publishing is a world renowned authority in producing journals, magazines, websites and services that enable researchers and research organizations to present their work to a world-wide audience. Laser Physics, the first English-language scientific journal in Russia, was founded in 1990 on the initiative of Alexander M Prokhorov, a pioneer and leader in laser physics research. Professor Prokhorov served as the first Editor-in-Chief of the journal until 2002. We are proud that it is our 23rd year of publishing Laser Physics and our 10th year of publishing Laser Physics Letters. We would like to honour the memory of our friend, late Professor Igor Yevseyev, whose enthusiasm and unwavering dedication to our journals contributed most significantly to their success. It was initially his idea in 2011 to approach IOP with a partnership proposal. We deeply regret that he is no longer with us as we enter this productive alliance. Now, in partnership with IOP, we are turning a new page in providing world-wide access to the cutting-edge research results in our journals, serving our well established global audience. We see new horizons opening for our journals for years to come and hope that our readers share our enthusiasm and aspirations. Please accept our best wishes for all your new scientific endeavors in the exciting field of laser physics.

  2. Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models

    Science.gov (United States)

    Nguyen, Liem H.; Robinton, Daisy A.; Seligson, Marc; Wu, Linwei; Li, Lin; Rakheja, Dinesh; Comerford, Sarah; Ramezani, Saleh; Sun, Xiankai; Parikh, Monisha; Yang, Erin; Powers, John T.; Shinoda, Gen; Shah, Samar; Hammer, Robert; Daley, George Q.; Zhu, Hao

    2014-01-01

    SUMMARY Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often overexpress Lin28, but its role in tumor initiation or maintenance has not been definitively addressed. We report that LIN28B overexpression is sufficient to initiate hepatoblastoma and hepatocellular carcinoma in murine models. We also detected Lin28b overexpression in MYC-driven hepatoblastomas, and liver-specific deletion of Lin28a/b reduced tumor burden, extended latency, and prolonged survival. Both intravenous siRNA against Lin28b and conditional Lin28b deletion reduced tumor burden and prolonged survival. Igf2bp proteins are upregulated and Igf2bp3 is required in the context of LIN28B overexpression to promote growth. Thus, multiple murine models demonstrate that Lin28b is both sufficient to initiate liver cancer and necessary for its maintenance. PMID:25117712

  3. Metabolomics of hexachlorocyclohexane (HCH) transformation: ratio of LinA to LinB determines metabolic fate of HCH isomers.

    Science.gov (United States)

    Geueke, Birgit; Garg, Nidhi; Ghosh, Sneha; Fleischmann, Thomas; Holliger, Christof; Lal, Rup; Kohler, Hans-Peter E

    2013-04-01

    Although the production and use of technical hexachlorocyclohexane (HCH) and lindane (the purified insecticidal isomer γ-HCH) are prohibited in most countries, residual concentrations still constitute an immense environmental burden. Many studies describe the mineralization of γ-HCH by bacterial strains under aerobic conditions. However, the metabolic fate of the other HCH isomers is not well known. In this study, we investigated the transformation of α-, β-, γ-, δ-, ε-HCH, and a heptachlorocyclohexane isomer in the presence of varying ratios of the two enzymes that initiate γ-HCH degradation, a dehydrochlorinase (LinA) and a haloalkane dehalogenase (LinB). Each substrate yielded a unique metabolic profile that was strongly dependent on the enzyme ratio. Comparison of these results to those of in vivo experiments with different bacterial isolates showed that HCH transformation in the tested strains was highly optimized towards productive metabolism of γ-HCH and that under these conditions other HCH-isomers were metabolized to mixtures of dehydrochlorinated and hydroxylated side-products. In view of these results, bioremediation efforts need very careful planning and toxicities of accumulating metabolites need to be evaluated. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

  4. U.S. EPA Metadata Editor (EME)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EPA Metadata Editor (EME) allows users to create geospatial metadata that meets EPA's requirements. The tool has been developed as a desktop application that...

  5. EDITORIAL: Message from the Editor Message from the Editor

    Science.gov (United States)

    Thomas, Paul

    2012-01-01

    Board Members, Guest Editors of special editions and those referees who were already listed in the last years. The following people have been selected: Marina Becoulet, CEA Cadarache, France Russell Doerner, University of California - San Diego, USA Emiliano Fable, Max-Planck-Institut fuer Plasmaphysik, Germany Akihide Fujisawa, Kyushi University, Japan Gerardo Giruzzi, CEA Cadarache, France Grigory Kagan, LANL, USA Morten Lennholm, CCFE, UK Akinobu Matsuyama, NIFS, Japan Peter Stangeby, University of Toronto, Canada Leonid Zakharov, PPPL, USA In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2011. Our thanks to them! Authors The winner of the 2011 Nuclear Fusion Award is H. Urano, for the paper 'Dimensionless parameter dependence of H-mode pedestal width using hydrogen and deuterium plasmas in JT-60U' (Nucl. Fusion 48 045008). The award was presented at the Plasma Conference 2011 (Joint meeting of 28th JSPF Annual Meeting, The 29th Symposium on Plasma Processing, and Division of Plasma Physics, 2011 Autumn Meeting of The Physical Society of Japan). This is the sixth year that the International Atomic Energy Agency (IAEA) has awarded an annual prize to honour exceptional work published in Nuclear Fusion. IOP Publishing has generously made a contribution of $2500 to the award. The Nuclear Fusion Electronic Archive The journal's electronic archive has been online since the beginning of the year. The archive has been a roaring success and has contributed to the nearly 300 000 downloads of journal papers in 2011. The archive can be accessed via http://iopscience.iop.org/0029-5515/page/Archive. It has direct links to 16 landmark papers, from authors such as Artsimovich and Mercier. The Nuclear Fusion office and IOP Publishing Just as the journal depends on the authors and referees, so its success is also

  6. [Report of the editors, 2013].

    Science.gov (United States)

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2014-01-01

    The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) objectives and attainments, (b) editorial activity, and (c) objectives for 2014. In 2013 the most relevant modification concerning the editorial activity has been the translation into English of the 5 manuscripts with abstract contained in each issue (http://www.revclinesp.es/). From the first January to the 30th September 2013 we received 458 manuscripts (50.9 manuscripts per month), a similar figure to that obtained in 2012 (51.1 manuscripts per month). The acceptance rate of the 443 manuscripts whose editorial process has been concluded was 23.7% (originals, 11.8%). We asked for 253 revisions to 186 reviewers and we received 74.4% revisions in less than 2 weeks (10.9 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 20,3 (half than in 2009). For «originals» this figure has dropped from 56.6 days in 2009 to 22.5 days in 2013. The mean time elapsed from manuscript reception to its on-line publication was 94.8 days in 2013 (110.5 in 2012 and 155.8 in 2011). In 2013 the collaboration with the working groups from the Internal Medicine Spanish Foundation has reported 17 published manuscripts. In 2013 we were informed that the Journal Citation Reports excluded Rev Clin Esp from its impact factor journal list due to its elevated self-citations. We have taken a number of actions to reduce self-citations and we expect to be a minority in 2014. Some other data concerning the editorial policy are encouraging. In this sense, manuscript citation to Rev Clin Esp published articles has seen a substantial increase from 19% in 2008 to 29% in 2012. We work to achieve the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000). The continuous renewal of the journal sections and the working groups collaboration are necessary elements to make our journal, each day

  7. Fetal deficiency of Lin28 programs life-long aberrations in growth and glucose metabolism

    Science.gov (United States)

    Shinoda, Gen; Shyh-Chang, Ng; de Soysa, T. Yvanka; Zhu, Hao; Seligson, Marc T.; Shah, Samar P.; Abo-Sido, Nora; Yabuuchi, Akiko; Hagan, John P.; Gregory, Richard I.; Asara, John M.; Cantley, Lewis C.; Moss, Eric G.; Daley, George Q.

    2013-01-01

    LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over-expression of Lin28a have shown related phenotypes. Here we describe the first comprehensive analysis of the physiologic consequences of Lin28a and Lin28b deficiency in knockout (KO) mice. Lin28a/b-deficiency led to dwarfism starting at different ages, and compound gene deletions showed a cumulative dosage effect on organismal growth. Conditional gene deletion at specific developmental stages revealed that fetal but neither neonatal nor adult deficiency resulted in growth defects and aberrations in glucose metabolism. Tissue-specific KO mice implicated skeletal muscle-deficiency in the abnormal programming of adult growth and metabolism. The effects of Lin28b KO can be rescued by Tsc1 haplo-insufficiency in skeletal muscles. Our data implicate fetal expression of Lin28a/b in the regulation of life-long effects on metabolism and growth, and demonstrate that fetal Lin28b acts at least in part via mTORC1 signaling. PMID:23666760

  8. Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development.

    Science.gov (United States)

    Vogt, Edgar J; Meglicki, Maciej; Hartung, Kristina Ilka; Borsuk, Ewa; Behr, Rüdiger

    2012-12-01

    The maternal nucleolus is required for proper activation of the embryonic genome (EGA) and early embryonic development. Nucleologenesis is characterized by the transformation of a nucleolar precursor body (NPB) to a mature nucleolus during preimplantation development. However, the function of NPBs and the involved molecular factors are unknown. We uncover a novel role for the pluripotency factor LIN28, the biological significance of which was previously demonstrated in the reprogramming of human somatic cells to induced pluripotent stem (iPS) cells. Here, we show that LIN28 accumulates at the NPB and the mature nucleolus in mouse preimplantation embryos and embryonic stem cells (ESCs), where it colocalizes with the nucleolar marker B23 (nucleophosmin 1). LIN28 has nucleolar localization in non-human primate (NHP) preimplantation embryos, but is cytoplasmic in NHP ESCs. Lin28 transcripts show a striking decline before mouse EGA, whereas LIN28 protein localizes to NPBs at the time of EGA. Following knockdown with a Lin28 morpholino, the majority of embryos arrest between the 2- and 4-cell stages and never develop to morula or blastocyst. Lin28 morpholino-injected embryos arrested at the 2-cell stage were not enriched with nucleophosmin at presumptive NPB sites, indicating that functional NPBs were not assembled. Based on these results, we propose that LIN28 is an essential factor of nucleologenesis during early embryonic development.

  9. 107 Définition structurale des linéaments par traitement d'image ...

    African Journals Online (AJOL)

    Valued Packard Bell Customer

    The Ngovayang massif represents a key domain in understanding the geodynamics of the northern border of the Congo craton in South Cameroon. Remote sensing works .... linéaments liés au socle rocheux et aux accidents tectoniques (Minyem, 1994 [2]). Ces linéaments sont repartis selon trois directions. - la direction ...

  10. Becoming an Online Editor: Perceived Roles and Responsibilities of Wikipedia Editors

    Science.gov (United States)

    Littlejohn, Allison; Hood, Nina

    2018-01-01

    Introduction: We report on the experiences of a group of people as they become Wikipedia editors. We test Benkler's (2002) theory that commons-based production processes accelerate the creation of capital, questioning what knowledge production processes do people engage in as they become editors? The analysis positions the development of editing…

  11. EDITORIAL: Letter from the Editor

    Science.gov (United States)

    Hauptmann, Peter

    2006-12-01

    Dear authors and reviewers of articles for Measurement Science and Technology, I would like to thank all those who have published papers with us in 2006, and special thanks go to those of you who have kindly reviewed articles for the journal this year. I would also like to take this opportunity to update you on some of the developments on the journal this year. As many of you are no doubt aware our impact factor (a measure of the average number of times recent papers are referred to by others) has remained above 1 for the second year in a row. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization agreeing with my own assessment. This year we have welcomed several new faces to our Editorial Board and International Advisory Board. We are delighted to welcome Professor Hirofumi Yamada of the University of Kyoto as a representative from Japan. From China we have been joined by Professor Xuzong Chen of Peking University and Professor Zhiyi Wei of Chinese Academy of Sciences, Beijing. Professor Ivan Marusic from University of Minnesota and Dr Paul Williams of the National Institute of Standards and Technology in Boulder have joined as North American representatives. As usual you will be able to submit your articles through them or direct to the Editorial Office in Bristol, UK. As part of our ongoing initiative to give our authors' work the highest visibility, all articles are freely available online for 30 days from the date of publication, allowing all researchers to read and view the latest research as soon as it is published, and this year there have been many interesting articles to read! As regular readers are aware, Measurement Science and Technology publishes special issues and features, which highlight an area of current interest. This year's topics included

  12. From Editor vol 11, No.4

    OpenAIRE

    Ugur Demiray

    2010-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 11, Number: 4. In this issue it is published 4 notes for Editor, 12 articles, 2 book and one conference reviews. And this time, 27 authors from 10 different countries are placed. These published articles are from Bangldesh, Greece, India, Israel, Malaysia, Nigeria, Portugal, Singapore, Turkey and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on PREZI: A Differen...

  13. CERN Courier editors through 50 years

    CERN Multimedia

    2009-01-01

    The 50th anniversary of the first publication of the CERN Courier provided the opportunity for a modest celebration on 2 September 2009. All six of the principal editors that the magazine has had over its 50 years met together for the first time. After getting acquainted and re-acquainted over lunch, they gathered in the library at CERN to answer questions about producing the magazine over the years. From right to left, from the first editor to the present incumbent: Roger Anthoine, Alec Hester, Brian Southworth, Gordon Fraser, James Gillies and Christine Sutton.

  14. Regulation of C. elegans L4 cuticle collagen genes by the heterochronic protein LIN-29.

    Science.gov (United States)

    Abete-Luzi, Patricia; Eisenmann, David M

    2018-05-01

    The cuticle, the outer covering of the nematode C. elegans, is synthesized five times during the worm's life by the underlying hypodermis. Cuticle collagens, the major cuticle component, are encoded by a large family of col genes and, interestingly, many of these genes express predominantly at a single developmental stage. This temporal preference motivated us to investigate the mechanisms underlying col gene expression and here we focus on a subset of col genes expressed in the L4 stage. We identified minimal promoter regions of <300 bp for col-38, col-49, and col-63. In these regions, we predicted cis-regulatory sequences and evaluated their function in vivo via mutagenesis of a col-38p::yfp reporter. We used RNAi to study the requirement for candidate transcription regulators ELT-1 and ELT-3, LIN-29, and the LIN-29 co-factor MAB-10, and found LIN-29 to be necessary for the expression of four L4-specific genes (col-38, col-49, col-63, and col-138). Temporal misexpression of LIN-29 was also sufficient to activate these genes at a different developmental stage. The LIN-29 DNA-binding domain bound the col-38, col-49, and col-63 minimal promoters in vitro. For col-38 we showed that the LIN-29 sites necessary for reporter expression in vivo are also bound in vitro: this is the first identification of specific binding sites for LIN-29 necessary for in vivo target gene expression. © 2018 Wiley Periodicals, Inc.

  15. In vitro expansion of Lin+ and Lin− mononuclear cells from human peripheral blood

    International Nuclear Information System (INIS)

    Norhaiza, H. Siti; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul; Rohaya, M. A. W.

    2013-01-01

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin − ) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin + ) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin − cell population. The ability of Lin + and Lin − to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin + and Lin − were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin + mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin − stem cells were not able to survive in proliferation medium however, addition of cytokines into the proliferation

  16. Lin Receives 2010 Natural Hazards Focus Group Award for Graduate Research

    Science.gov (United States)

    2010-11-01

    Ning Lin has been awarded the Natural Hazards Focus Group Award for Graduate Research, given annually to a recent Ph.D. recipient for outstanding contributions to natural hazards research. Lin's thesis is entitled “Multi-hazard risk analysis related to hurricanes.” She is scheduled to present an invited talk in the Extreme Natural Events: Modeling, Prediction, and Mitigation session (NH20) during the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. Lin will be formally presented with the award at the Natural Hazards focus group reception on 14 December 2010.

  17. A Microsoft Windows version of the MCNP visual editor

    International Nuclear Information System (INIS)

    Schwarz, R.A.; Carter, L.L.; Pfohl, J.

    1999-01-01

    Work has started on a Microsoft Windows version of the MCNP visual editor. The MCNP visual editor provides a graphical user interface for displaying and creating MCNP geometries. The visual editor is currently available from the Radiation Safety Information Computational Center (RSICC) and the Nuclear Energy Agency (NEA) as software package PSR-358. It currently runs on the major UNIX platforms (IBM, SGI, HP, SUN) and Linux. Work has started on converting the visual editor to work in a Microsoft Windows environment. This initial work focuses on converting the display capabilities of the visual editor; the geometry creation capability of the visual editor may be included in future upgrades

  18. (Executive Editor). Microsoft Encarta Encyclopedia Deluxe 2000 ...

    African Journals Online (AJOL)

    In this regard it can be used to search only the articles, any of the multimedia features, or all the features. The editors have retained the pinpointer's form and have also opted for the same initial-alphabetical listing of lemmas in the main display window of the pinpointer. This maintains the continuity in this line of products and.

  19. Graphical Editor of the DDS Topology Configuration

    CERN Document Server

    Rusinov, Aleksandar

    2015-01-01

    An editor for the DDS topology configuration is created to allow the viewing of an existing topology, the editing of a topology, the creation of a new topology and the saving of a topology as a topology language XML file to be run directly on DDS or to be reloaded again for further editing. The development of the editor was started at GSI Darmstadt at the end of last year. The editor is designed as a web application that works on the client side. Recent and powerful JavaScript libraries were used – ReactJS and JointJS. It has two menus for editing – one for the declarative part and another for the executable part. A graph visualisation of the topology has also been developed and implemented fully to the editor. The output files have been tested and fully verified on the DDS. Future work will involve representation of the pipeline process and investigation on behavior when larger and more sophisticated topologies are used.

  20. Lin28 Mediates Cancer Chemotherapy Resistance via Regulation of miRNA Signaling.

    Science.gov (United States)

    Xu, Chaoyang; Xie, Shuduo; Song, Chunjiao; Huang, Liming; Jiang, Zhinong

    2014-06-01

    Chemotherapy resistance is one of the major obstacles limiting the success of cancer drug treatment. Among the mechanisms of resistance to chemotherapy treatment, there are those closely related to P-Glycoprotein, multidrug resistance-related protein, glutathione S-transferase pi and topoisomerase-II. Lin28 is a highly conserved RNA-binding protein, it consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs. In previous preclinical and clinical studies, positive Lin28 expression in cancer cells was correlated with decreased sensitivity to chemotherapy. And Lin28 could mediate cancer chemotherapy resistance via regulation of miR107 and Let-7 MiRNA. This article reviews current knowledge on predictive value of Lin28 in response to chemotherapy. Better understanding of its role may facilitate patient's selection of therapeutic regimen and lead to optimal clinical outcome.

  1. a worldwide assessment of medical journal editors' practices and ...

    African Journals Online (AJOL)

    responding editors reported having access to the Internet, making participation in ... of improving the quality of medical science and practice.! A critical activity of ... undertook a worldwide survey of medical editors to determine their interest in a ...

  2. Lin28b stimulates the reprogramming of rat Müller glia to retinal progenitors

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Chen; Tao, Zui; Xue, Langyue; Zeng, Yuxiao [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Wang, Yi, E-mail: wangyieye@aliyun.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Xu, Haiwei, E-mail: haiweixu2001@163.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Yin, Zheng Qin, E-mail: qinzyin@aliyun.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China)

    2017-03-01

    In lower-order vertebrates, Müller glia exhibit characteristics of retinal progenitor cells, while in higher vertebrates, such as mammals, the regenerative capacity of Müller glia is limited. Recently, we reported that Lin28b promoted the trans-differentiation of Müller cells to rod photoreceptor and bipolar cells in the retina of retinitis pigmentosa rat model, whereas it is unclear whether Lin28b can stimulate the reprogramming of Müller glia in vitro for transplantation into a damaged retina. In the present study, Long-Evens rat Müller glia were infected with Adeno-Lin28b or Adeno-GFP. Over-expression of Lin28b in isolated rat Müller glia resulted in the suppression of GFAP expression, enhancement of cell proliferation and a significant increase of the expression of retinal progenitor markers 5 days after infection. Moreover, Lin28b caused a significant reduction of the Let-7 family of microRNAs. Following sub-retinal space transplantation, Müller glia-derived retinal progenitors improved b-wave amplification of 30d Royal College of Surgeons retinitis pigmentosa model (RCS-P+) rats, as detected by electroretinography (ERG) recordings. Taken together, these data suggest that the up-regulation of Lin28b expression facilitated the reprogramming of Müller cells toward characteristics of retinal progenitors. - Highlights: • Lin28b reprograms Müller glia to retinal progenitors. • Let-7 micrRNAs are suppressed by Lin28b. • Transplantation of reprogrammed Müller glia restores retinal function.

  3. Lin28b stimulates the reprogramming of rat Müller glia to retinal progenitors

    International Nuclear Information System (INIS)

    Zhao, Chen; Tao, Zui; Xue, Langyue; Zeng, Yuxiao; Wang, Yi; Xu, Haiwei; Yin, Zheng Qin

    2017-01-01

    In lower-order vertebrates, Müller glia exhibit characteristics of retinal progenitor cells, while in higher vertebrates, such as mammals, the regenerative capacity of Müller glia is limited. Recently, we reported that Lin28b promoted the trans-differentiation of Müller cells to rod photoreceptor and bipolar cells in the retina of retinitis pigmentosa rat model, whereas it is unclear whether Lin28b can stimulate the reprogramming of Müller glia in vitro for transplantation into a damaged retina. In the present study, Long-Evens rat Müller glia were infected with Adeno-Lin28b or Adeno-GFP. Over-expression of Lin28b in isolated rat Müller glia resulted in the suppression of GFAP expression, enhancement of cell proliferation and a significant increase of the expression of retinal progenitor markers 5 days after infection. Moreover, Lin28b caused a significant reduction of the Let-7 family of microRNAs. Following sub-retinal space transplantation, Müller glia-derived retinal progenitors improved b-wave amplification of 30d Royal College of Surgeons retinitis pigmentosa model (RCS-P+) rats, as detected by electroretinography (ERG) recordings. Taken together, these data suggest that the up-regulation of Lin28b expression facilitated the reprogramming of Müller cells toward characteristics of retinal progenitors. - Highlights: • Lin28b reprograms Müller glia to retinal progenitors. • Let-7 micrRNAs are suppressed by Lin28b. • Transplantation of reprogrammed Müller glia restores retinal function.

  4. Le nævus épidermique verruqueux inflammatoire linéaire ...

    African Journals Online (AJOL)

    Le nævus épidermique verruqueux inflammatoire linéaire (NEVIL) est une affection rare correspondant à des hyperplasies épidermiques bénignes qui se présentent cliniquement sous forme de lésions linéaires unilatérales hyperkératosiques. Une adolescente âgée de 16 ans, sans antécédents, présentait depuis la ...

  5. OPM Scheme Editor 2: A graphical editor for specifying object-protocol structures

    Energy Technology Data Exchange (ETDEWEB)

    Chen, I-Min A.; Markowitz, V.M.; Pang, F.; Ben-Shachar, O.

    1993-07-01

    This document describes an X-window based Schema Editor for the Object-Protocol Model (OPM). OPM is a data model that supports the specification of complex object and protocol classes. objects and protocols are qualified in OPM by attributes that are defined over (associated with) value classes. Connections of object and protocol classes are expressed in OPM via attributes. OPM supports the specification (expansion) of protocols in terms of alternative and sequences of component (sub) protocols. The OPM Schema Editor allows specifying, displaying, modifying, and browsing through OPM schemas. The OPM Schema Editor generates an output file that can be used as input to an OPM schema translation tool that maps OPM schemas into definitions for relational database management systems. The OPM Schema Editor was implemented using C++ and the X11 based Motif toolkit, on Sun SPARCstation under Sun Unix OS 4.1. This document consists of the following parts: (1) A tutorial consisting of seven introductory lessons for the OPM Schema Editor. (2) A reference manual describing all the windows and functions of the OPM Schema Editor. (3) An appendix with an overview of OPM.

  6. Proxima: a presentation-oriented editor for structured documents

    OpenAIRE

    Schrage, M.M.

    2004-01-01

    A typical computer user deals with a large variety of documents, such as text files, spreadsheets, and web pages. The applications for constructing and modifying these documents are called editors (e.g. text editors, spreadsheet applications, and HTML editors). Despite the apparent differences between editors, the core editing behavior, whether performed in a word-processor or a spreadsheet, is largely similar: document fragments may be copied and pasted, and new parts of the document may be ...

  7. Proxima: a presentation-oriented editor for structured documents

    NARCIS (Netherlands)

    Schrage, M.M.

    2004-01-01

    A typical computer user deals with a large variety of documents, such as text files, spreadsheets, and web pages. The applications for constructing and modifying these documents are called editors (e.g. text editors, spreadsheet applications, and HTML editors). Despite the apparent differences

  8. Four are named Editors of Earth Interactions

    Science.gov (United States)

    Eric J. Barron of the Earth System Science Center at The Pennsylvania State University has been named chief editor of the new electronic journal, Earth Interactions. This journal will be co-published by AGU, the American Meteorological Society, and the Association of American Geographers. The three societies jointly agreed on the appointment of Barron. Each of the societies also appointed an editor to the board. George F. Hepner for AAG is from the Department of Geography at the University of Utah, David T. Sandwell for AGU is at the Institute of Geophysics and Planetary Physics at Scripps Institution of Oceanography, and Kevin E. Trenberth for AMS is at the Climate and Global Dynamics Division at the National Center for Atmospheric Research.

  9. From the Editor Vol: 6 number 2

    OpenAIRE

    Ugur Demiray

    2005-01-01

    From the Editor Dear TOJDES Readers Time flies. Another quarter has begun. It is a great pleasure to welcome you to the 18th issue, the Volume: 6, Number: 2 of The Turkish Online Journal of Distance Education (TOJDE), of looking forward. TOJDE has been driving and shaping by our editorial board, reviewers, authors and even unbelievable readers. In the April 2005 issue, TOJDE publishes peer-reviewed distance education articles under four umbrellas: applications, feature topics, researches, ...

  10. Mary Shelley as editor of Percy Shelley

    OpenAIRE

    Allen, Richard

    2001-01-01

    This chapter explores Mary Shelley's work as the founding editor of Percy Shelley's poetry. It sets out the circumstances of Mary Shelley's life after the death of Percy Shelley, her financial dependence on Percy Shelley's father, and the restrictions placed on publication by Shelley's father. It then sets out the strategies Mary Shelley used to construct a biography of Percy Shelley from the poem, thus establishing a Romantic biography of Percy Shelley which has endured into the 20th century,

  11. NEW EDITOR OF THE CMS BULLETIN

    CERN Multimedia

    Walter Van Doninck has been the Editor of the CMS Bulletin since 2000. The Bulletin not only helps disseminate information but also records the progress of CMS. Walter is handing over to Karl Gill. We would like to thank Walter for carrying out this task with enthusiasm and efficiency for so long. We should also thank Karl for accepting to take over and wish him well over the coming exciting period.

  12. Workbench surface editor of brain cortical surface

    Science.gov (United States)

    Dow, Douglas E.; Nowinski, Wieslaw L.; Serra, Luis

    1996-04-01

    We have developed a 3D reach-in tool to manually reconstruct 3D cortical surface patches from 2D brain atlas images. The first application of our cortex editor is building 3D functional maps, specifically Brodmann's areas. This tool may also be useful in clinical practice to adjust incorrectly mapped atlas regions due to the deforming effect of lesions. The cortex editor allows a domain expert to control the correlation of control points across slices. Correct correlation has been difficult for 3D reconstruction algorithms because the atlas slices are far apart and because of the complex topology of the cortex which differs so much from slice to slice. Also, higher precision of the resulting surfaces is demanded since these define 3D brain atlas features upon which future stereotactic surgery may be based. The cortex editor described in this paper provides a tool suitable for a domain expert to use in defining the 3D surface of a Brodmann's area.

  13. New Editors Appointed for Sections of Journal of Geophysical Research

    Science.gov (United States)

    2009-04-01

    New editors have been appointed for the Atmospheres, Biogeosciences, and Oceans sections of the Journal of Geophysical Research (JGR). Joost de Gouw (NOAA, Boulder, Colo.) and Renyi Zhang (Texas A&M, College Station) are filling the vacancies of retiring Atmospheres section editors John Austin and Jose Fuentes. De Gouw and Zhang join the continuing editors Steven Ghan and Yinon Rudich. Sara Pryor (Indiana University, Bloomington) is joining the Atmospheres section editorial board as an associate editor now; she will transition to editor in January 2010.

  14. Association of Lin-28A rs3811464 Variant with Susceptibility to Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Mona Khodabandeh

    2017-11-01

    Full Text Available Introduction: It has been suggested that Lin-28A and the let-7 microRNA family (Lin-28/let-7 axis play a critical role in the control of glucose metabolism, insulin sensitivity and resistance to diabetes. Aim: This case-control study aimed at evaluating the association between Lin-28 rs3811464 polymorphism and the susceptibility to Type 2 Diabetes (T2D in a sample of Iranian population. Materials and Methods: This study involved 172 T2D patients and 160 non-diabetic age and gender-matched controls. Lin 28A rs3811464 genotypes were determined by Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP technique. Results: The results showed that the frequency of the AA genotype was significantly higher in control subjects than in diabetic patients (13.12% vs. 4.65%. In addition, binary logistic regression analysis revealed that rs3811464-AA genotype was significantly associated to T2D after adjustment for BMI, age and lipid profiles. Indeed, subjects with AA genotype were less likely to develop T2D than GG and AG subjects (OR of 0.26, 95% CI 0.10-0.66, p=0.005. Conclusion: The findings of our study suggest that the Lin 28A rs3811464 is associated with type 2 diabetes susceptibility and subjects with AA genotypes were less likely to develop T2D diabetes.

  15. Clinical application of Lin's biopsy grasper for intrauterine targeted biopsy and polypectomy during office hysteroscopy.

    Science.gov (United States)

    Cheng, Hsin-Yi; Lin, Bao-Liang; Tseng, Jen-Yu; Ueno, Kazunori; Nakada, Sakura

    2018-06-01

    Hysteroscopy has widely been used for diagnosis of the uterine cavity; however, target biopsy has often been difficult in part to the inherent limitations of ancillary instruments. Lin's biopsy grasper was specifically designed to work in conjunction with a flexible hysteroscope to obtain intrauterine biopsy under transabdominal sonography. Herein, we share our clinical experience in the management of endometrial abnormalities with the use of Lin's biopsy grasper during office-based hysteroscopy. From February 2006 to November 2016, the use of Lin's biopsy grasper for tissue biopsy was attempted on 126 cases. We retrospectively recorded and analyzed the patients' preoperative characteristics and biopsy outcomes to demonstrate the feasibility and efficacy of Lin's biopsy grasper. Out of the one hundred and twenty-six enrolled patients, satisfactory targeted biopsies were achieved; including high diagnostic rate (92.1%, with 116 cases confirmed histologically) and adequate tissue retrieval (77.8%, with 98 cases obtaining optimal specimen volume). All patients tolerated the procedure without analgesics or anesthesia. Diagnostic flexible hysteroscopy combined with the use of Lin's biopsy grasper has proven to be an effective tool for intrauterine evaluation and obtaining tissue sample. Copyright © 2018. Published by Elsevier B.V.

  16. Lin4Neuro: a customized Linux distribution ready for neuroimaging analysis.

    Science.gov (United States)

    Nemoto, Kiyotaka; Dan, Ippeita; Rorden, Christopher; Ohnishi, Takashi; Tsuzuki, Daisuke; Okamoto, Masako; Yamashita, Fumio; Asada, Takashi

    2011-01-25

    A variety of neuroimaging software packages have been released from various laboratories worldwide, and many researchers use these packages in combination. Though most of these software packages are freely available, some people find them difficult to install and configure because they are mostly based on UNIX-like operating systems. We developed a live USB-bootable Linux package named "Lin4Neuro." This system includes popular neuroimaging analysis tools. The user interface is customized so that even Windows users can use it intuitively. The boot time of this system was only around 40 seconds. We performed a benchmark test of inhomogeneity correction on 10 subjects of three-dimensional T1-weighted MRI scans. The processing speed of USB-booted Lin4Neuro was as fast as that of the package installed on the hard disk drive. We also installed Lin4Neuro on a virtualization software package that emulates the Linux environment on a Windows-based operation system. Although the processing speed was slower than that under other conditions, it remained comparable. With Lin4Neuro in one's hand, one can access neuroimaging software packages easily, and immediately focus on analyzing data. Lin4Neuro can be a good primer for beginners of neuroimaging analysis or students who are interested in neuroimaging analysis. It also provides a practical means of sharing analysis environments across sites.

  17. An editor's memoir: reflections and premonitions.

    Science.gov (United States)

    Kovacs, Arthur L

    2013-12-01

    The author served as the second Editor of this journal. In the article that follows, he reminisces about the state of the publication when he assumed responsibility for it and comments on the nature of the profession during the time of his incumbency. He reflects on the creative innovation and ferment in both the theories and tactics of psychotherapy unfolding during the 1970s and closes with statements of concern about developments within the field that are ominous and have come to the fore over the decades since he left office in 1983.

  18. LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans

    DEFF Research Database (Denmark)

    Romanos, Teresa Rojo; Pladevall-Morera, David; Langebeck-Jensen, Kasper

    2017-01-01

    HLH) family of transcription factors has multiple functions in neurogenesis. Here, we identified the LIN-32/Atonal bHLH transcription factor as a key regulator of URXL/R oxygen-sensing neuron development in Caenorhabditis elegans. When LIN-32/Atonal expression is lost, the expression of URX specification......Development of complex nervous systems requires precisely controlled neurogenesis. The generation and specification of neurons occur through the transcriptional and post-Transcriptional control of complex regulatory networks. In vertebrates and invertebrates, the proneural basic-helix-loop-helix (b...... and terminal differentiation genes is abrogated. As such, lin-32 mutant animals are unable to respond to increases in environmental oxygen. The URX neurons are generated from a branch of the cell lineage that also produces the CEPDL/R and URADL/R neurons. We found development of these neurons is also defective...

  19. Identification and Characterization of Genes That Interact with Lin-12 in Caenorhabditis Elegans

    OpenAIRE

    Tax, F. E.; Thomas, J. H.; Ferguson, E. L.; Horvitz, H. R.

    1997-01-01

    We identified and characterized 14 extragenic mutations that suppressed the dominant egg-laying defect of certain lin-12 gain-of-function mutations. These suppressors defined seven genes: sup-17, lag-2, sel-4, sel-5, sel-6, sel-7 and sel-8. Mutations in six of the genes are recessive suppressors, whereas the two mutations that define the seventh gene, lag-2, are semi-dominant suppressors. These suppressor mutations were able to suppress other lin-12 gain-of-function mutations. The suppressor ...

  20. [Professor LIN Guohua's experience of gold implantation at acupoint for rheumatoid arthritis].

    Science.gov (United States)

    Li, Jingjing; Pei, Wenya

    2015-12-01

    Based on the pathogenesis and symptom of rheumatoid arthritis (RA), professor LIN Guohua's unique opinion and method for RA in clinical treatment are summarized and analyzed. In the opinion of Professor Lin, RA is considered as "Jinbi" and "Gubi" in TCM, which is caused by deficient root with superficial excess. Based on the symptoms of RA, attention should be focused on lung-kidney diagnosis and treatment, and gold and catgut implantation at acupoint can be mutually combined, which is aimed to provide a special and effective method for clinical treatment of RA.

  1. A Virtual Environments Editor for Driving Scenes

    Directory of Open Access Journals (Sweden)

    Ronald R. Mourant

    2003-12-01

    Full Text Available The goal of this project was to enable the rapid creation of three-dimensional virtual driving environments. We designed and implemented a high-level scene editor that allows a user to construct a driving environment by pasting icons that represent 1 road segments, 2 road signs, 3 trees and 4 buildings. These icons represent two- and three-dimensional objects that have been predesigned. Icons can be placed in the scene at specific locations (x, y, and z coordinates. The editor includes the capability of a user to "drive" a vehicle using a computer mouse for steering, accelerating and braking. At any time during the process of building a virtual environment, a user may switch to "Run Mode" and inspect the three-dimensional scene by "driving" through it using the mouse. Adjustments and additions can be made to the virtual environment by going back to "Build Mode". Once a user is satisfied with the threedimensional virtual environment, it can be saved in a file. The file can used with Java3D software that enables the traversing of three-dimensional environments. The process of building virtual environments from predesigned icons can be applied to many other application areas. It will enable novice computer users to rapidly construct and use three-dimensional virtual environments.

  2. Communicating specialized knowledge - negotiating knowledge communication between writer and editor

    DEFF Research Database (Denmark)

    Petersen, Margrethe

    In communicating research findings, authors of academic journal articles face the challenge of overcoming the barriers posed by the knowledge asymmetries between (a) authors and journal readership and (b) authors and editors. Considering the general taxonomy of the submission procedure and the ke...... role of academic journal editors, the issue of whether, regardless of the quality of the submissions received, editors are sometimes insurmountable barriers to knowledge communication should be debated....

  3. Web-Based Media Contents Editor for UCC Websites

    Science.gov (United States)

    Kim, Seoksoo

    The purpose of this research is to "design web-based media contents editor for establishing UCC(User Created Contents)-based websites." The web-based editor features user-oriented interfaces and increased convenience, significantly different from previous off-line editors. It allows users to edit media contents online and can be effectively used for online promotion activities of enterprises and organizations. In addition to development of the editor, the research aims to support the entry of enterprises and public agencies to the online market by combining the technology with various UCC items.

  4. Letter from the New Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Pabulo Henrique Rampelotto

    2014-01-01

    Full Text Available It is my great pleasure to serve as the new Editor-in-Chief of Life, a journal concerned with fundamental questions on the origins and nature of life, evolution of biosystems and astrobiology. With my experience as Executive Editor, Senior Editor and Guest Editor of so many successful special issues (some of them in MDPI journals [1–6], I am committed to making the journal a success, with the launch of exciting special issues, publication of high quality papers, as well as inclusion of the journal in major indexing and abstracting services. In this editorial, I present my view and plans for the journal.

  5. EDITORIAL: Incoming Editor-in-Chief

    Science.gov (United States)

    Lidström, Suzanne

    2012-04-01

    When Professor Anders Bárány took over as the Executive Editor of Physica Scripta, in 1986, he talked of his trepidation at having to 'dress himself' in his predecessor's 'editorial coveralls'. At that time, they had been worn by Professor Nils Robert Nilsson, a major figure in the physics community, for almost 20 years. Just one year prior to this, Professor Roger Wäppling had been recruited to the position of Subeditor in conjunction with a decision to expand the number of contributions in the field of condensed matter physics, to turn it into one of the dominant subjects in the broad-based journal. Physica Scripta had already gained a reputation for being a high quality journal with wide coverage of both experimental and theoretical physics. Interestingly, in the mid 1980s, the number of papers submitted had been growing and an impressive 250 submissions per year had been attained, with all of the manuscripts being handled in-house. Not many miles away in the town of Uppsala, a group of English students was stepping off a train on a magnificent snowy day in January to embark on their final year projects. A couple of us enjoyed ourselves so much that we stayed on afterwards as PhD students, thereby encountering the mixed pleasure of studying physics in a second language for the first time. I used to copy the notes down meticulously in Swedish, then try to work backwards with a textbook to improve my language skills. One day, returning from a particularly incomprehensible lecture on solid state physics, I showed my roommates my notes and asked if they could please explain what the lecture had been about: 'I don't know', they replied, 'but this bit is about sheep!' Meanwhile, back at Physica Scripta, the journal continued to flourish: 400 submissions were received in 1996, and the march of progress was well underway. Manuscripts could now be sent in on disks and Physica Scripta was available on the World Wide Web. Roger was appointed to manage the journal and

  6. Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.

    Science.gov (United States)

    Liu, Wan-Ju; Reece-Hoyes, John S; Walhout, Albertha J M; Eisenmann, David M

    2014-05-13

    Hox genes encode master regulators of regional fate specification during early metazoan development. Much is known about the initiation and regulation of Hox gene expression in Drosophila and vertebrates, but less is known in the non-arthropod invertebrate model system, C. elegans. The C. elegans Hox gene lin-39 is required for correct fate specification in the midbody region, including the Vulval Precursor Cells (VPCs). To better understand lin-39 regulation and function, we aimed to identify transcription factors necessary for lin-39 expression in the VPCs, and in particular sought factors that initiate lin-39 expression in the embryo. We used the yeast one-hybrid (Y1H) method to screen for factors that bound to 13 fragments from the lin-39 region: twelve fragments contained sequences conserved between C. elegans and two other nematode species, while one fragment was known to drive reporter gene expression in the early embryo in cells that generate the VPCs. Sixteen transcription factors that bind to eight lin-39 genomic fragments were identified in yeast, and we characterized several factors by verifying their physical interactions in vitro, and showing that reduction of their function leads to alterations in lin-39 levels and lin-39::GFP reporter expression in vivo. Three factors, the orphan nuclear hormone receptor NHR-43, the hypodermal fate regulator LIN-26, and the GATA factor ELT-6 positively regulate lin-39 expression in the embryonic precursors to the VPCs. In particular, ELT-6 interacts with an enhancer that drives GFP expression in the early embryo, and the ELT-6 site we identified is necessary for proper embryonic expression. These three factors, along with the factors ZTF-17, BED-3 and TBX-9, also positively regulate lin-39 expression in the larval VPCs. These results significantly expand the number of factors known to directly bind and regulate lin-39 expression, identify the first factors required for lin-39 expression in the embryo, and hint at a

  7. Kinetic and sequence-structure-function analysis of known LinA variants with different hexachlorocyclohexane isomers.

    Directory of Open Access Journals (Sweden)

    Pooja Sharma

    Full Text Available BACKGROUND: Here we report specific activities of all seven naturally occurring LinA variants towards three different isomers, α, γ and δ, of a priority persistent pollutant, hexachlorocyclohexane (HCH. Sequence-structure-function differences contributing to the differences in their stereospecificity for α-, γ-, and δ-HCH and enantiospecificity for (+- and (--α -HCH are also discussed. METHODOLOGY/PRINCIPAL FINDINGS: Enzyme kinetic studies were performed with purified LinA variants. Models of LinA2(B90A A110T, A111C, A110T/A111C and LinA1(B90A were constructed using the FoldX computer algorithm. Turnover rates (min(-1 showed that the LinAs exhibited differential substrate affinity amongst the four HCH isomers tested. α-HCH was found to be the most preferred substrate by all LinA's, followed by the γ and then δ isomer. CONCLUSIONS/SIGNIFICANCE: The kinetic observations suggest that LinA-γ1-7 is the best variant for developing an enzyme-based bioremediation technology for HCH. The majority of the sequence variation in the various linA genes that have been isolated is not neutral, but alters the enantio- and stereoselectivity of the encoded proteins.

  8. An Effective Implementation of K-opt Moves for the Lin-Kernighan TSP Heuristic

    DEFF Research Database (Denmark)

    Helsgaun, Keld

    Local search with k-change neighborhoods, k-opt, is the most widely used heuristic method for the traveling salesman problem (TSP). This report presents an effective implementation of k-opt for the Lin- Kernighan TSP heuristic. The effectiveness of the implementation is demonstrated with extensive...

  9. Combustion of Pure, Hydrolyzed and Methyl Ester Formed of Jatropha Curcas Lin oil

    Directory of Open Access Journals (Sweden)

    Muhaji Muhaji

    2015-10-01

    Full Text Available The density and viscosity of vegetable oil are higher than that of diesel oil. Thus its direct combustion in the diesel engine results many problems. This research was conducted to investigate the flame characteristics of combustion of jatropha curcas lin in pure, hydrolyzed and methyl ester form. The results indicated that the combustion of pure jatropha curcas lin occurs in three stages, hydrolyzed in two stages    and methyl ester in one stage. For pure jatropha curcas lin, in the first stage, unsaturated fatty acid burned for  0.265 s.  It is followed by saturated fatty acid, burned for 0.389 s in the second stage. And, in the last stage is the burned of glycerol for 0.560 s. Meanwhile for hydrolyzed one, in the first stage, unsaturated fatty acid burned for 0.736 s, followed by saturated fatty acid, burned  for 0.326 s in the second stage. And the last, for methyl ester is the burned for 0.712 s. The highest burning rate was for methyl ester which was 0.003931cc/s. The energy releasing rate of methyl ester, which was for 13,628.67 kcal/(kg.s resembled that of diesel oil the most, while the lowest rate was for pure jatropha curcas lin which was 8,200.94 kcal/(kg.s. In addition, massive explosion occurred in the fuel containing unsaturated fatty acid and glycerol

  10. linäituse stendid = Outdoor exhibition stands / Gert Sarv, Galina Burnakova

    Index Scriptorium Estoniae

    Sarv, Gert, 1971-

    2013-01-01

    Eesti Sisearhitektide Liidu 2012. aasta parima eseme preemia pälvinud välinäituse stendidest Vanasadama Admiraliteedi basseini kaldapealsel. Autorid: Gert Sarv, Galina Burnakova, Loreida Hein. Sisearhitekti ja ESLi aastapreemiate žürii liikme Tea Tammelaane arvamus

  11. A role for Lin28 in primordial germ cell development and germ cell malignancy

    Science.gov (United States)

    West, Jason A.; Viswanathan, Srinivas R.; Yabuuchi, Akiko; Cunniff, Kerianne; Takeuchi, Ayumu; Park, In-Hyun; Sero, Julia E.; Zhu, Hao; Perez-Atayde, Antonio; Frazier, A. Lindsay; Surani, M. Azim; Daley, George Q.

    2009-01-01

    The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwarts efforts to investigate molecular mechanisms of germ cell specification. Stella marks the minute founder population of the germ lineage1,2. Here we differentiate mouse embryonic stem cells (ESCs) carrying a Stella transgenic reporter into putative PGCs in vitro. The Stella+ cells possess a transcriptional profile similar to embryo-derived PGCs, and like their counterparts in vivo, lose imprints in a time-dependent manner. Using inhibitory RNAs to screen candidate genes for effects on the development of Stella+ cells in vitro, we discovered that Lin28, a negative regulator of let-7 microRNA processing3-6, is essential for proper PGC development. We further show that Blimp1, a let-7 target and a master regulator of PGC specification7-9, can rescue the effect of Lin28-deficiency during PGC development, thereby establishing a mechanism of action for Lin28 during PGC specification. Over-expression of Lin28 promotes formation of Stella+ cells in vitro and PGCs in chimeric embryos, and is associated with human germ cell tumours. The differentiation of putative PGCs from ESCs in vitro recapitulates the early stages of gamete development in vivo, and provides an accessible system for discovering novel genes involved in germ cell development and malignancy. PMID:19578360

  12. Cryptanalysis of Lin et al.'s Efficient Block-Cipher-Based Hash Function

    NARCIS (Netherlands)

    Liu, Bozhong; Gong, Zheng; Chen, Xiaohong; Qiu, Weidong; Zheng, Dong

    2010-01-01

    Hash functions are widely used in authentication. In this paper, the security of Lin et al.'s efficient block-cipher-based hash function is reviewed. By using Joux's multicollisions and Kelsey et al.'s expandable message techniques, we find the scheme is vulnerable to collision, preimage and second

  13. Single-tube linear DNA amplification (LinDA) for robust ChIP-seq

    NARCIS (Netherlands)

    Shankaranarayanan, P.; Mendoza-Parra, M.A.; Walia, M.; Wang, L.; Li, N.; Trindade, L.M.; Gronemeyer, H.

    2011-01-01

    Genome-wide profiling of transcription factors based on massive parallel sequencing of immunoprecipitated chromatin (ChIP-seq) requires nanogram amounts of DNA. Here we describe a high-fidelity, single-tube linear DNA amplification method (LinDA) for ChIP-seq and reChIP-seq with picogram DNA amounts

  14. New explicit and exact solutions of the Benney–Kawahara–Lin equation

    International Nuclear Information System (INIS)

    Yuan-Xi, Xie

    2009-01-01

    In this paper, we present a combination method of constructing the explicit and exact solutions of nonlinear partial differential equations. And as an illustrative example, we apply the method to the Benney–Kawahara–Lin equation and derive its many explicit and exact solutions which are all new solutions. (general)

  15. Variational principles of fluid mechanics and electromagnetism: imposition and neglect of the Lin constraint

    International Nuclear Information System (INIS)

    Allen, R.R. Jr.

    1987-01-01

    The Lin constraint has been utilized by a number of authors who have sought to develop Eulerian variational principles in both fluid mechanics and electromagnetics (or plasmadynamics). This dissertation first reviews the work of earlier authors concerning the development of variational principles in both the Eulerian and Lagrangian nomenclatures. In the process, it is shown whether or not the Euler-Lagrange equations that result from the variational principles are equivalent to the generally accepted equations of motion. In particular, it is shown in the case of several Eulerian variational principles that imposition of the Lin constraint results in Euler-Lagrange equations equivalent to the generally accepted equations of motion, whereas neglect of the Lin constraint results in restrictive Euler-Lagrange equations. In an effort to improve the physical motivation behind introduction of the Lin constraint, a new variational constraint is developed based on teh concept of surface forces within a fluid. Additionally, it is shown that a quantity often referred to as the canonical momentum of a charged fluid is not always a constant of the motion of the fluid; and it is demonstrated that there does not exist an unconstrained Eulerian variational principle giving rise to the generally accepted equations of motion for both a perfect fluid and a cold, electromagnetic fluid

  16. From the Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Simeon Oka

    2010-01-01

    Full Text Available The Editorial Board of the journal Thermal Science is continuing to pay great attention to the processes in internal combustion engines, both due to their environmental impact and ability to use renewable energy sources i. e. different types of biofuels. Concerning that motor vehicles contribute about 14% of the global CO2 emission, it is understandable that many research efforts are devoted to processes in internal combustion engines and use of biofuels. The number of submitted papers dealing with processes in internal combustion engines is growing from months to months, so in the journal Thermal Science also will published in 2011 one issue devoted to the same topics. Papers submitted are already in the reviewing process. Professor Dragoslava Stojiljkovi} and Professor Stojan Petrovi} as Guest editors, had again a difficult task to make appropriate choice of the papers, covering wide range of topics. I am very grateful to Guest editors for their extremely competent choice of the topics and papers. Reviewers of the papers made, also, tremendous contributions to the quality of the papers published. This time, also, as in No. 3, 2009, we asked experts in traffic engineering to give their contribution. They pointed out importance of the internal combustion engine energy efficiency, vehicle fleet operation management and logistic efficiency, and painted large scale picture of the environmental problems caused by large density traffic. We hope that this point of view will make new impulse for many new joint projects with the aim to investigate impact of the processes in internal combustion engines and logistic of motor fleet management, and organization of traffic flows, especially in large towns, on environment. Papers devoted to the thermal processes in internal combustion engines are grouped in Part one of this issue. Due to large number of papers accepted for publication, we have been forced to introduce Part two, in which are grouped selected

  17. Current status in development of new EXFOR editor

    International Nuclear Information System (INIS)

    Sarsembayeva, A.; Ebata, S.; Kato, K.; Aikawa, M.; Imai, S.; Chiba, M.; Otuka, N.

    2016-01-01

    A new stand-alone type editor for EXFOR is being developed in Hokkaido University Nuclear Reaction Data Centre (JCPRG). The new editor is designed to allow compilers to save time and to avoid mistakes by using its advanced features. The features included in the latest release are described such as filterable and dynamic suggestion fields. (author)

  18. Peer reviews and the role of a journal editor

    Science.gov (United States)

    Obtaining peer reviews for manuscripts submitted to scientific journals is becoming increasingly difficult. Changes to the system are necessary, and editors must cultivate and maintain a solid base of reviewers to help evaluate journal submissions. This article outlines some steps editors can and sh...

  19. Object class hierarchy for an incremental hypertext editor

    Directory of Open Access Journals (Sweden)

    A. Colesnicov

    1995-02-01

    Full Text Available The object class hierarchy design is considered due to a hypertext editor implementation. The following basic classes were selected: the editor's coordinate system, the memory manager, the text buffer executing basic editing operations, the inherited hypertext buffer, the edit window, the multi-window shell. Special hypertext editing features, the incremental hypertext creation support and further generalizations are discussed.

  20. How Managing Editors View and Deal with Newspaper Ethical Issues.

    Science.gov (United States)

    Anderson, Douglas

    1987-01-01

    Claims there is awareness and concern about journalism ethics among daily newspaper managing editors. Asserts that although ethical issues are being addressed to some degree, greater efforts could be made to see that reporters and editors are apprised of codes of ethics. (MM)

  1. Table of Contents | Editor | Ghana Journal of Linguistics

    African Journals Online (AJOL)

    2016. Editorial Committee: Ọbádélé Kambon (Editor-in-Chief; University of Ghana). E. Kweku Osam (Consulting Editor; University of Ghana). Gordon S. Adika (University of Ghana). Nana Aba A. Amfo (University of Ghana). Jemima A. Anderson (University of Ghana). Charles O. Marfo (Kwame Nkrumah University of Science ...

  2. The Introductory Psychology Textbook Market: Perceptions of Authors and Editors.

    Science.gov (United States)

    Griggs, Richard A.; Jackson, Sherri L.

    1989-01-01

    Surveys psychology textbook authors and editors on their perceptions of the introductory psychology textbook market. Finds that the textbook market is divided into three levels according to quality, and that authors and editors are not familiar with most textbooks. Notes that the growth of used book companies has adversely affected the market.…

  3. The RAE and Publications: A Review of Journal Editors.

    Science.gov (United States)

    Talib, Ameen Ali

    2000-01-01

    Surveyed editors of academic journals about publication issues related to Britain's Research Assessment Exercise (RAE), a process of grading and funding universities based on published research output. Editors were asked about research quality and output, publication practices, academics' willingness to referee manuscripts, and proliferation of…

  4. JSME: a free molecule editor in JavaScript.

    Science.gov (United States)

    Bienfait, Bruno; Ertl, Peter

    2013-01-01

    A molecule editor, i.e. a program facilitating graphical input and interactive editing of molecules, is an indispensable part of every cheminformatics or molecular processing system. Today, when a web browser has become the universal scientific user interface, a tool to edit molecules directly within the web browser is essential. One of the most popular tools for molecular structure input on the web is the JME applet. Since its release nearly 15 years ago, however the web environment has changed and Java applets are facing increasing implementation hurdles due to their maintenance and support requirements, as well as security issues. This prompted us to update the JME editor and port it to a modern Internet programming language - JavaScript. The actual molecule editing Java code of the JME editor was translated into JavaScript with help of the Google Web Toolkit compiler and a custom library that emulates a subset of the GUI features of the Java runtime environment. In this process, the editor was enhanced by additional functionalities including a substituent menu, copy/paste, drag and drop and undo/redo capabilities and an integrated help. In addition to desktop computers, the editor supports molecule editing on touch devices, including iPhone, iPad and Android phones and tablets. In analogy to JME the new editor is named JSME. This new molecule editor is compact, easy to use and easy to incorporate into web pages. A free molecule editor written in JavaScript was developed and is released under the terms of permissive BSD license. The editor is compatible with JME, has practically the same user interface as well as the web application programming interface. The JSME editor is available for download from the project web page http://peter-ertl.com/jsme/

  5. Martin Stutzmann: Editor, Teacher, Scientist and Friend

    Science.gov (United States)

    Cardona, Manuel

    2005-03-01

    On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality

  6. Academic Degradation and the Retreat of the Editors: Academic Irregularities and the Spreading of Academic Corruption from an Editor's Perspective

    Science.gov (United States)

    Xun, Gong

    2007-01-01

    Against the backdrop of the grave academic crisis in China, editors have become the objects of wooing, favor-currying, connections-seeking, and collusions; they have been targeted for attacks, plots, extortions, and encroachments. Editing and publishing have become avenues for academic irregularities and academic corruption. Editors have the power…

  7. From the Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Simeon Oka

    2010-01-01

    affiliated at the Faculty of Mechanical Engineering in Kragujevac. Guest editor, Professor Dr. Milun Babić, had an extremely difficult job to make proper selection of papers, representing research results of his Department and Faculty of Mechanical Engineering, not only in fundamental and applied research, but also in practical applications. I am greatly thankful to him since he presented not only most interesting scientific results, but also cases of best practise realized on the basis of the research results. At the same time, in his introductory review paper he explain research policy in the field of thermal sciences, energy efficiency and use of renewable energy sources having the main aim to solve more important energy and environmental problems of the local community, as well as to introduce energy management, environmental management, and sustainable development. This is one of the main characteristics of the set of papers selected by Guest editor for this Supplement issue. Realization of the full chain – fundamental research, applied research development and demonstration (R&D&D is not too often, especially in developing countries. I hope, that paper selection that made for this issue by Guest editor Professor Dr. Milun Babić, in many cases evidently presents that it is possible, even with small funds available in Serbia.

  8. Biodegradation of γ-hexachlorocyclohexane by transgenic hairy root cultures of Cucurbita moschata that accumulate recombinant bacterial LinA.

    Science.gov (United States)

    Nanasato, Yoshihiko; Namiki, Sayuri; Oshima, Masao; Moriuchi, Ryota; Konagaya, Ken-Ichi; Seike, Nobuyasu; Otani, Takashi; Nagata, Yuji; Tsuda, Masataka; Tabei, Yutaka

    2016-09-01

    γ-HCH was successfully degraded using LinA-expressed transgenic hairy root cultures of Cucurbita moschata . Fusing an endoplasmic reticulum-targeting signal peptide to LinA was essential for stable accumulation in the hairy roots. The pesticide γ-hexachlorocyclohexane (γ-HCH) is a persistent organic pollutant (POP) that raises public health and environmental pollution concerns worldwide. Although several isolates of γ-HCH-degrading bacteria are available, inoculating them directly into γ-HCH-contaminated soil is ineffective because of the bacterial survival rate. Cucurbita species incorporate significant amounts of POPs from soils compared with other plant species. Here, we describe a novel bioremediation strategy that combines the bacterial degradation of γ-HCH and the efficient uptake of γ-HCH by Cucurbita species. We produced transgenic hairy root cultures of Cucurbita moschata that expressed recombinant bacterial linA, isolated from the bacterium Sphingobium japonicum UT26. The LinA protein was accumulated stably in the hairy root cultures by fusing an endoplasmic reticulum (ER)-targeting signal peptide to LinA. Then, we demonstrated that the cultures degraded more than 90 % of γ-HCH (1 ppm) overnight and produced the γ-HCH metabolite 1,2,4-trichlorobenzene, indicating that LinA degraded γ-HCH. These results indicate that the gene linA has high potential for phytoremediation of environmental γ-HCH.

  9. LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency

    Science.gov (United States)

    Tsanov, Kaloyan M.; Pearson, Daniel S.; Wu, Zhaoting; Han, Areum; Triboulet, Robinson; Seligson, Marc T.; Powers, John T.; Osborne, Jihan K.; Kane, Susan; Gygi, Steven P.; Gregory, Richard I.; Daley, George Q.

    2016-01-01

    Signaling and post-transcriptional gene control are both critical for the regulation of pluripotency1,2, yet how they are integrated to influence cell identity remains poorly understood. LIN28 (also known as LIN28A), a highly conserved RNA-binding protein (RBP), has emerged as a central post-transcriptional regulator of cell fate through blockade of let-7 microRNA (miRNA) biogenesis and direct modulation of mRNA translation3. Here we show that LIN28 is phosphorylated by MAPK/ERK in pluripotent stem cells (PSCs), which increases its levels via post-translational stabilization. LIN28 phosphorylation had little impact on let-7 but enhanced LIN28’s effect on its direct mRNA targets, revealing a mechanism that uncouples LIN28’s let-7-dependent and independent activities. We have linked this mechanism to the induction of pluripotency by somatic cell reprogramming and the transition from naïve to primed pluripotency. Collectively, our findings indicate that MAPK/ERK directly impacts LIN28, defining an axis that connects signaling, post-transcriptional gene control, and cell fate regulation. PMID:27992407

  10. The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.

    Science.gov (United States)

    McDaniel, Kelly; Huang, Li; Sato, Keisaku; Wu, Nan; Annable, Tami; Zhou, Tianhao; Ramos-Lorenzo, Sugeily; Wan, Ying; Huang, Qiaobing; Francis, Heather; Glaser, Shannon; Tsukamoto, Hidekazu; Alpini, Gianfranco; Meng, Fanyin

    2017-07-07

    The let-7/Lin28 axis is associated with the regulation of key cellular regulatory genes known as microRNAs in various human disorders and cancer development. This study evaluated the role of the let-7/Lin28 axis in regulating a mesenchymal phenotype of hepatic stellate cells in alcoholic liver injury. We identified that ethanol feeding significantly down-regulated several members of the let-7 family in mouse liver, including let-7a and let-7b. Similarly, the treatment of human hepatic stellate cells (HSCs) with lipopolysaccharide (LPS) and transforming growth factor-β (TGF-β) significantly decreased the expressions of let-7a and let-7b. Conversely, overexpression of let-7a and let-7b suppressed the myofibroblastic activation of cultured human HSCs induced by LPS and TGF-β, as evidenced by repressed ACTA2 (α-actin 2), COL1A1 (collagen 1A1), TIMP1 (TIMP metallopeptidase inhibitor 1), and FN1 (fibronectin 1); this supports the notion that HSC activation is controlled by let-7. A combination of bioinformatics, dual-luciferase reporter assay, and Western blot analysis revealed that Lin28B and high-mobility group AT-hook (HMGA2) were the direct targets of let-7a and let-7b. Furthermore, Lin28B deficiency increased the expression of let-7a/let-7b as well as reduced HSC activation and liver fibrosis in mice with alcoholic liver injury. This feedback regulation of let-7 by Lin28B is verified in hepatic stellate cells isolated by laser capture microdissection from the model. The identification of the let-7/Lin28 axis as an important regulator of HSC activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis and novel therapeutic approaches for human alcoholic liver diseases. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

    OpenAIRE

    Nowak, Jakub Stanislaw; Hobor, Fruzsina; Downie Ruiz Velasco, Angela; Choudhury, Nila Roy; Heikel, Gregory; Kerr, Alastair; Ramos, Andres; Michlewski, Gracjan

    2017-01-01

    Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3’-5’ exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a polyuridylation-independent mechanism. Here we reveal that the sequences and structural characteristics of pre-let-7 and pre-miRNA-9 are eliciting two distinct modes of binding to Lin28a. We presen...

  12. Editors' message--Hydrogeology Journal in 2003

    Science.gov (United States)

    Voss, Clifford; Olcott, Perry; Schneider, Robert

    2004-01-01

    Hydrogeology Journal appeared in six issues containing a total of 710 pages and 48 major articles, including 31 Papers and 14 Reports, as well as some Technical Notes and Book Reviews. The number of submitted manuscripts continues to increase. The final issue of 2003 also contained the annual volume index. Hydrogeology Journal (HJ) is an international forum for hydrogeology and related disciplines and authors in 2003 were from about 28 countries. Articles advanced hydrogeologic science and described hydrogeologic systems in many regions worldwide. These articles focused on a variety of general topics and on studies of hydrogeology in 24 countries: Afghanistan, Algeria, Argentina, Australia, Bangladesh, Belgium, Canada, Chile, China, Denmark, France, India, Italy, Mexico, Netherlands, New Zealand, Nigeria, Norway, Portugal, Russia, South Africa, Switzerland, Turkey, and U.S.A. The Guest Editor of the 2003 HJ theme issue on “Hydromechanics in Geology and Geotechnics”, Ove Stephansson, assembled a valuable collection of technical reviews and research papers from eminent authors on important aspects of the subject area.

  13. Towards the implementation of a system for manuscript editor certification

    Directory of Open Access Journals (Sweden)

    Hyun Jung Yi

    2016-02-01

    Full Text Available Style and format are important criteria for evaluating a journal and indexing it in major databases. In Korean science, technology, and medical journals, interest in manuscript editing has increased over the past seven to eight years, and the responsibilities of manuscript editors have expanded as well. However, since no clear standards for the roles and qualifications for manuscript editors are yet available, a formal certification system is needed to establish appropriate standards and to provide professional training. To identify ways of developing a manuscript editor certification program in Korea, this study investigated similar certification programs in and outside the country and surveyed 195 Korean editors, manuscript editors, publishers, and medical librarians. The survey revealed that manuscript editors were necessary (mean score of 4.38 on a five-point Likert scale, with a score of 5 indicating strong agreement, and that their main contributions were efficiently managing the editorial board, improving the accuracy of references, and accelerating the editing process. The respondents were also positive about the possibility of implementing a manuscript editor certification; 45.1% showed interest in becoming certified, and 47.1% reported interest in hiring a certified manuscript editor. Regarding the system for issuing certification, respondents favored a professional training course (53.1%, validation of work experience (27.1%, or an examination (16.8%. This study concludes that it is essential to establish a formal certification program to train manuscript editors properly, and an examination system is the most efficient and suitable method for managing the certification process.

  14. EDITORIAL: Incoming Editor-in-Chief

    Science.gov (United States)

    Webb, Steve

    2006-01-01

    Physics in Medicine and Biology (PMB) is a journal that originated in the UK but is now rightly regarded as one of the pre-eminent international journals for the publication of material coming within its remit. It is 50 years old and its maturity is an outcome of the consistent support of high performing authors, a supportive and professional publishing house, dedicated referees, many vigorous and conscientious editorial boards and the collective input of the 10 previous Editors as listed in his incoming editorial (January 2000 issue) by the retiring Editor, Professor Alun Beddoe. The scientific climate and it associated publication modus operandi in the 1950s was very different from that at the current time and the journal has evolved to reflect this. Hence today the scope of content is somewhat broader, the size of the journal is vastly greater, the whole publication process is slicker and more efficient and a paper in PMB is highly prized by its authors and those who look to quality factors and impact. The quality of the journal still relies on the voluntary labour and expertise of its busy international referees and Board members. For many years I have tried to place my own research material in PMB and encourage my teams to do likewise, not only acknowledging the prestige of the journal but also because of the extraordinarily fast turnaround time of all the processes without any loss of quality. This serves us very well and the publishing team are to be congratulated. Some things seem to change more slowly or not at all, however. The prediction, when I started my research career, that books and journals would be dinosaurs by now has manifestly not come true and, whilst most of us are addicted (and why not?) to the electronic ways of doing things that can be done by more traditional ways, PMB and a packet of reprints from time to time arriving by post still has a reassuring feel despite the fact that the papers have been `on-line' for a while before. An incoming

  15. Fragmented Encounters, Social Slippages: Lin Huiyin's "In Ninety-Nine Degree Heat"

    Directory of Open Access Journals (Sweden)

    Carles Prado-Fonts

    2010-01-01

    Full Text Available The article reads Lin Huiyin’s short story “In Ninety-Nine Degree Heat” (1934 in relation to the context of 1930s China, as an innovative literary work which combines elements from both the Chinese and the Western traditions, and as a text which informs readers not only of the problematic of class and gender issues in 1930s Chinese society but also of the context of the liuxuesheng who returns to China –like Lin Huiyin herself. Focusing on questions like otherness, representation, and encounters, the essay analyzes how the episodic narrative structure of Lin’s short story echoes social and representational discourses in post-May Fourth China, at the same time that it explores issues such as social inequality, otherness and alienation, which were crucial to the liuxuesheng, and which reflect Lin’s own experience as a returned and alienated liuxuesheng at the time.

  16. GENII-LIN: a Multipurpose Health Physics Code Built on GENII-1.485

    Directory of Open Access Journals (Sweden)

    Marco Sumini

    2006-10-01

    Full Text Available The aim of the GENII-LIN project was to develop an open source multipurpose health physics code running on Linux platform, for calculating radiation dose and risk from radionuclides released to the environment. The general features of the GENII-LIN system include [1] capabilities for calculating radiation dose both for acute and chronic releases, with options for annual dose, committed dose and accumulated dose [2] capabilities for evaluating exposure pathways including direct exposure via water (swimming, boating, fishing, soil (buried and surface sources and air (semi-infinite cloud and finite cloud model, inhalation pathways and ingestion pathways. The release scenarios considered are: - acute release to air, from ground level or elevated sources, or to water; - chronic release to air, from ground level or elevated sources, or to water; - initial contamination of soil or surfaces. Keywords: radiation protection, Linux, health physics, risk analysis.

  17. An Adaptation of the Kernighan-Lin Heuristic to the Simple Graph Partitioning Problem

    DEFF Research Database (Denmark)

    Sørensen, Michael Malmros

    1999-01-01

    to this problem of the Kernighan-Lin exchange heuristic, which was originally developed for the closely related 2-partition problem. The evaluation is carried out on problem instances on graphs with up to 50 nodes for which the optimal partition values are known or upper bounds are available. The computational...... results show that among all instances with known optimal values the best partition values found by a randomized version of this heuristic lie well within 1% off the optimum....

  18. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.

    Science.gov (United States)

    Dai, Qian; Luan, Guangxin; Deng, Li; Lei, Tingjun; Kang, Han; Song, Xu; Zhang, Yujun; Xiao, Zhi-Xiong; Li, Qintong

    2014-05-08

    Primordial dwarfism (PD) is characterized by global growth failure, both during embryogenesis and postnatally. Loss-of-function germline mutations in La ribonucleoprotein domain family, member 7 (LAPR7) have recently been linked to PD. Paradoxically, LARP7 deficiency was previously assumed to be associated with increased cell growth and proliferation via activation of positive transcription elongation factor b (P-TEFb). Here, we show that Larp7 deficiency likely does not significantly increase P-TEFb activity. We further discover that Larp7 knockdown does not affect pluripotency but instead primes embryonic stem cells (ESCs) for differentiation via downregulation of Lin28, a positive regulator of organismal growth. Mechanistically, we show that Larp7 interacts with a poly(A) polymerase Star-PAP to maintain Lin28 mRNA stability. We propose that proper regulation of Lin28 and PTEFb is essential for embryonic cells to achieve a sufficient number of cell divisions prior to differentiation and ultimately to maintain proper organismal size. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Dynamiques complexes et morphogenèse Introduction aux sciences non linéaires

    CERN Document Server

    Misbah, Chaouqi

    2011-01-01

    Les sciences non linéaires ont pour objet l’ensemble des phénomènes dont l’analyse résiste au principe de superposition. Elles concernent en grande partie les systèmes dits « complexes » dont l’interaction et l’interdépendance entre les parties empêchent de prédire précisément l’évolution du système. Pour expliquer ces phénomènes, deux approches complémentaires ont été proposées : la théorie des bifurcations et la théorie des catastrophes. Mais la pleine compréhension et la modélisation de la non-linéarité restent chacune un défi pour les scientifiques du XXIe siècle. C’est dans la perspective d’accompagner tous ceux qui voudront le relever que ce livre a été conçu. Son objectif est d’exposer au lecteur le langage et le formalisme nécessaires à l’étude de la non-linéarité. Partant d’exemples simples, pour ensuite atteindre un niveau d’abstraction visant l’universalité, l’auteur explore les divers scénarios possibles de bifurcations et les catastr...

  20. From the Editor Vol: 6 number 2

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2005-04-01

    Full Text Available From the Editor Dear TOJDE’S Readers Time flies. Another quarter has begun. It is a great pleasure to welcome you to the 18th issue, the Volume: 6, Number: 2 of The Turkish Online Journal of Distance Education (TOJDE, of looking forward. TOJDE has been driving and shaping by our editorial board, reviewers, authors and even unbelievable readers. In the April 2005 issue, TOJDE publishes peer-reviewed distance education articles under four umbrellas: applications, feature topics, researches, and support systems. In addition, it publishes short and non-peer-reviewed book reviews and editorial letters. The main goal of TOJDE is to provide you with exclusive resources with the highest quality, and also to reach diverse audiences, as highly qualified individuals and researchers, around the world. Also, I am excited about that TOJDE is referenced as a course material by diverse institutions from the globe and very proud to share this news with you. You can see details in the news section. In this issue, it has been given place to two notes for editor submissions, eleven articles, two book reviews, 8 news, one journal about information and communication technology and one institution about technology integration via distance education named as RETA. And also interesting links deal with TOJDE take place in the literature. This issue's articles came from Canada, India, Malaysia, Nigeria, Turkey, United Kingdom and United States (according to alphabetical order. The first “Notes for Editors” is from Turkey on Using of Marketing Communication for Distance Education Institutions submitted by Dr. R. Ayhan YILMAZ, Anadolu University, Communication Sciences Faculty, Eskisehir, TURKEY. And second one arrived from India. It is titled as “Information and Communication Technology for Poverty Reduction” written by Motilal SHARMA. The first article came from Canada. It is entitled as “Understanding PISA” written by Dr. Stephen DOWNES. He mentions in his paper

  1. Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences.

    Science.gov (United States)

    Grandien, K; Sommer, R J

    2001-08-15

    Hox transcription factors have been implicated in playing a central role in the evolution of animal morphology. Many studies indicate the evolutionary importance of regulatory changes in Hox genes, but little is known about the role of functional changes in Hox proteins. In the nematodes Pristionchus pacificus and Caenorhabditis elegans, developmental processes can be compared at the cellular, genetic, and molecular levels and differences in gene function can be identified. The Hox gene lin-39 is involved in the regulation of nematode vulva development. Comparison of known lin-39 mutations in P. pacificus and C. elegans revealed both conservation and changes of gene function. Here, we study evolutionary changes of lin-39 function using hybrid transgenes and site-directed mutagenesis in an in vivo assay using C. elegans lin-39 mutants. Our data show that despite the functional differences of LIN-39 between the two species, Ppa-LIN-39, when driven by Cel-lin-39 regulatory elements, can functionally replace Cel-lin-39. Furthermore, we show that the MAPK docking and phosphorylation motifs unique for Cel-LIN-39 are dispensable for Cel-lin-39 function. Therefore, the evolution of lin-39 function is driven by changes in regulatory elements rather than changes in the protein itself.

  2. From Editor vol 11, No.4

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2010-10-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 11, Number: 4. In this issue it is published 4 notes for Editor, 12 articles, 2 book and one conference reviews. And this time, 27 authors from 10 different countries are placed. These published articles are from Bangldesh, Greece, India, Israel, Malaysia, Nigeria, Portugal, Singapore, Turkey and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on PREZI: A Different Way to Present. Prezi represents the first step toward other visual tools that are not, strictly speaking, and presentations at all, but may yet find uses in classrooms. Browser-based programs that allow for concept mapping and brainstorming (sometimes with drawing and even inter-user chat functionality approximate some of prezi’s best features yet stand on their own as organizing tools that provide inspiration for the users. Examples include bubble.us, Thinkature, Mindmeister, and Graphic Organizer. The second notes for editor is titled as “Investigating the Factor Structure ıf The Blog Attitude Scale” which is written by Zahra SHAHSAVAR, Tan Bee HOON, S. Vahid ARYADOUST from Malaysia. Their study reports the design and development of a blog attitude scale (BAS. In exploratory factor analysis, three factors were discovered: blog anxiety, blog desirability, and blog self-efficacy; 14 items were excluded. The extracted items were subjected to a confirmatory factor analysis which lent further support to the BAS underpinning structure. “Implementation of An Online Teacher Assessment/Appraisal In Technical Education Institution: A Case Study” is the third paper for “Notes for Editor” section of TOJDE’s in this issue. It has written by Sraboni MANDAL, Dr. SANJAY, Dajnish SHRIVASTAVA from National Institute of Technology, Jamshedpur, INDIA. The purpose to discusses a case study of implementation of teacher appraisal system which initially non

  3. Response to Niklasson's comment on Lin, et al. (2012) : "the relation between postural movement and bilateral motor integration".

    Science.gov (United States)

    Lin, Chin-Kai; Kuo, Bor-Chen; Wu, Huey-Min

    2014-10-01

    In the study of Lin, Wu, Lin, Wu, Wu, Kuo, and Yeung (2012 ), the relationship between the validity of postural movement and bilateral motor integration in terms of sensory integration theory was examined. Postural movement is the ability to use the antigravity postures required for stabilization of the neck, trunk and upper extremities via muscle co-contractions in the neck and upper extremities, and balance. Niklasson's (2013 ) comment argued that postural movement should include primitive reflexes in terms of the general abilities approach. Niklasson (2013 ) focused on the efficacy of the treatment rather than the theoretical frameworks implied in the therapeutic activities. For that purpose Lin, et al. (2012 ) used sensory integration as the theoretical foundation, and the relationship between postural movement and bilateral motor integration was assessed via empirical data. The result of Lin, et al. (2012 ) was offered as a theoretical reference for therapeutic activities.

  4. Editorial first issue: Letter from the Editor

    Directory of Open Access Journals (Sweden)

    Farinaz Nasirinezhad

    2016-08-01

    Full Text Available Welcome to the first issue of Journal of Medical Physiology! Journal of Medical Physiology is a high-quality, peer reviewed, open access journal which will focus on physiology, biology, and neuroscience and their applications in clinic from the molecular levels to the levels of organs and systems.  In recent years knowledge of physiology has been under a great progress and is being taught as one of the major courses in medicine and allied fields in the universities. Many researchers are doing research in this field and try to find the basic mechanism and appropriate solution for diseases which are difficult to treat. The editorial board wants to create a balanced journal to help the researchers in the field of medicine and physiology to share the results of their research work. Like all good science, medical physiology has no national boundaries. Although we each have found our own niche where we work and feel most comfortable, science language is a common language and by this language scientist can learn from each other. We want Journal of Medical Physiology to be an international forum for sharing the best ideas. It will help researcher in the field of medicine and physiology to keep up with the science. We hope that this journal plays a major role in the development of the physiological sciences and contribute to the diffusion of scientific knowledge and to promote discussion among scientist. The journal will include original researches that are practical applications of known techniques as well as theoretical advances at the physiological sciences and medicine. I consider it a great honor being as Editor-in-Chief of Journal of Medical Physiology and I will do my best to face all challenges that confront the journal and striving to increase the quality and impact of the journal's content. Despite the inevitable push towards publishing in the highest impact factor journals possible, the other side of the coin is ensuring that your work is

  5. Red's natural editor, a program designed to edit FORTRAN programs

    International Nuclear Information System (INIS)

    Cullen, D.E.

    1993-01-01

    An EDITOR code is documented which supplements the 1994 ENDF Pre-processing Code Package which is available from the IAEA Nuclear Data Section for the processing of ENDF formatted nuclear data libraries. (author)

  6. Designing Epigenome Editors: Considerations of Biochemical and Locus Specificities.

    Science.gov (United States)

    Sen, Dilara; Keung, Albert J

    2018-01-01

    The advent of locus-specific protein recruitment technologies has enabled a new class of studies in chromatin biology. Epigenome editors enable biochemical modifications of chromatin at almost any specific endogenous locus. Their locus specificity unlocks unique information including the functional roles of distinct modifications at specific genomic loci. Given the growing interest in using these tools for biological and translational studies, there are many specific design considerations depending on the scientific question or clinical need. Here we present and discuss important design considerations and challenges regarding the biochemical and locus specificities of epigenome editors. These include how to account for the complex biochemical diversity of chromatin; control for potential interdependency of epigenome editors and their resultant modifications; avoid sequestration effects; quantify the locus specificity of epigenome editors; and improve locus specificity by considering concentration, affinity, avidity, and sequestration effects.

  7. Particle Track Visualization using the MCNP Visual Editor

    International Nuclear Information System (INIS)

    Schwarz, Randolph A.; Carter, Lee; Brown, Wendi A.

    2001-01-01

    The Monte Carlo N-Particle (MCNP) visual editor1,2,3 is used throughout the world for displaying and creating complex MCNP geometries. The visual editor combines the Los Alamos MCNP Fortran code with a C front end to provide a visual interface. A big advantage of this approach is that the particle transport routines for MCNP are available to the visual front end. The latest release of the visual editor by Pacific Northwest National Laboratory enables the user to plot transport data points on top of a two-dimensional geometry plot. The user can plot source points, collisions points, surface crossings, and tally contributions. This capability can be used to show where particle collisions are occurring, verify the effectiveness of the particle biasing, or show which collisions contribute to a tally. For a KCODE (criticality source) calculation, the visual editor can be used to plot the source points for specific cycles

  8. On the reduction of generalized polylogarithms to Li_n and Li_2_,_2 and on the evaluation thereof

    International Nuclear Information System (INIS)

    Frellesvig, Hjalte; Tommasini, Damiano; Wever, Christopher

    2016-01-01

    We give expressions for all generalized polylogarithms up to weight four in terms of the functions log, Li_n, and Li_2_,_2, valid for arbitrary complex variables. Furthermore we provide algorithms for manipulation and numerical evaluation of Li_n and Li_2_,_2, and add codes in Mathematica and C++ implementing the results. With these results we calculate a number of previously unknown integrals, which we add in appendix C.

  9. Expectations of an editor in case of an incident

    International Nuclear Information System (INIS)

    Widmer, H.P.

    1997-01-01

    Our major expectations about information of nuclear power station operators are: Truthfulness, comprehensibility, availability and editor's disposal when needed. The information must be clear and true. It has to give an account of the complex facts in which laymen readers fully understand. Editors rely on scientific support and the spokespersons' tolerance for media specific particularities; such as, competition, to be first in information, and time pressure. (orig.) [de

  10. Developing Visual Editors for High-Resolution Haptic Patterns

    DEFF Research Database (Denmark)

    Cuartielles, David; Göransson, Andreas; Olsson, Tony

    2012-01-01

    In this article we give an overview of our iterative work in developing visual editors for creating high resolution haptic patterns to be used in wearable, haptic feedback devices. During the past four years we have found the need to address the question of how to represent, construct and edit high...... resolution haptic patterns so that they translate naturally to the user’s haptic experience. To solve this question we have developed and tested several visual editors...

  11. LIN Dataset

    Data.gov (United States)

    Department of Homeland Security — This data is captured and helps to coordinate technical and scientific testing in the area of Trade Enforcement, WMD, Intellectual Property Rights, and Narcotics...

  12. EDITORIAL: Incoming Editor-in-Chief Incoming Editor-in-Chief

    Science.gov (United States)

    Birch, David

    2012-01-01

    It is a pleasure and an honour for me to be taking over as Editor-in-Chief of Measurement Science and Technology. MST is well known across research communities worldwide as a leading journal in which to publish new techniques and instrumentation. It has gained this enviable position largely because of the excellent guidance of its Editorial Board and dedicated staff at Institute of Physics Publishing over many years. I want to highlight in particular the contribution of the outgoing Editor Peter Hauptmann, and other Editors before him, in making the journal truly international. We thank Peter immensely for all his hard work in leading the journal, having exceptionally served two terms, each of five years. I come into the post of Editor at a very interesting and challenging time for research. The global recession is leading to cuts in research funding in many countries, researchers and their outputs are coming under closer scrutiny than ever before, and more is being expected of them. Journals play a critical role in monitoring and maintaining research standards, but we should be careful not to assume that journal Impact Factor is the sole measure of research quality. Although expediency may sometimes demand it, Impact Factor, as practitioners know, is subject dependent. One of the great things about science and technology for me is its level playing field. The key point is still innovation no matter where the work is done or where it is published. MST has a long pedigree of being the natural home of the highest quality papers from leading researchers wishing to report novel instrumentation and techniques. 2013 will mark the 90th anniversary of MST and we look forward to celebrating in style its sustained success. I recall with pride the first paper I published in Journal of Physics E: Scientific Instruments (as MST was previously titled) back in 1977. The paper reported the design and application of an early fluorescence lifetime spectrometer that I had constructed

  13. LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome.

    Directory of Open Access Journals (Sweden)

    Ayumi Matsumoto

    Full Text Available Interstitial deletion of 12q21 has been reported in four cases, which share several common clinical features, including intellectual disability (ID, low-set ears, and minor cardiac abnormalities. Comparative genomic hybridization (CGH analysis using the Agilent Human Genome CGH 180K array was performed with the genomic DNA from a two-year-old Japanese boy with these symptoms, as well as hypoplasia of the corpus callosum. Consequently, a 14 Mb deletion at 12q21.2-q21.33 (nt. 77 203 574-91 264 613 bp, which includes 72 genes, was detected. Of these, we focused on LIN7A, which encodes a scaffold protein that is important for synaptic function, as a possible responsible gene for ID, and we analyzed its role in cerebral cortex development. Western blotting analyses revealed that Lin-7A is expressed on embryonic day (E 13.5, and gradually increases in the mouse brain during the embryonic stage. Biochemical fractionation resulted in the enrichment of Lin-7A in the presynaptic fraction. Suppression of Lin-7A expression by RNAi, using in utero electroporation on E14.5, delayed neuronal migration on postnatal day (P 2, and Lin-7A-deficient neurons remained in the lower zone of the cortical plate and the intermediate zone. In addition, when Lin-7A was silenced in cortical neurons in one hemisphere, axonal growth in the contralateral hemisphere was delayed; development of these neurons was disrupted such that one half did not extend into the contralateral hemisphere after leaving the corpus callosum. Taken together, LIN7A is a candidate gene responsible for 12q21-deletion syndrome, and abnormal neuronal migration and interhemispheric axon development may contribute to ID and corpus callosum hypoplasia, respectively.

  14. From the Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Simeon Oka

    2011-01-01

    science. Included herein is a collection of original refereed research papers by well-established researchers in the field of nonlinear science. We hope that these papers will prove to be a timely and valuable reference for researchers in this area. Analytical approach to thermal science is challenging and promising, and is playing an even more important role in optimal design of various thermal problems. Considering this fact, selection of the papers for this special issue has the aim to show illustrating approaches to various thermal problems by various methods including fractal geometry and fractional calculus, and the present special issue can be used as paradigms for many other applications. I am deeply grateful to the Guest editors, Professor Ji-Huan He (now with National Engineering Laboratory of Modern Silk, Soochow University, Suzhow, China and Professor Lianchun Zheng (Department of Mathematics and Mechanics, University of Science and Technology Beijing, Beijing, China, for excellent paper selection, the job which is at the same time highly professional and delicate. I am sure, that readers will obtain realistic insight in how to apply the methods presented in this special issue to various problems.

  15. From the Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Simeon Oka

    2011-01-01

    while under review by the Journal." At the end I have a pleasure to frankly appreciate to Professor Jan Erik Johnsson, from Technical University of Denmark, Lyngby, for his contribution, as member of the International Advisory Board from the very beginning, to the scientific scope and orientation of the Journal, and to the quality of the papers published in more than 15 years. I am sorry that his wish was not to be member of the International Advisory Board, since he was retired. In the name of Editorial Boards of the journal Thermal Science I wish to him many nice activities in his free time. Finally, I am happy that, following the wish of Prof. Arun Mujumdar, the world known scientist and member of our International Advisory Board, that I can pay your attention to the link: http://serve.me.nus.edu.sg/arun/E_books.htm, where you can download many interesting e-books, and review of the activity of the Minerals, Metals and Materials Technology Centre, of the Faculty of Engineering, National University of Singapore. April, 2011 Professor Simeon Oka, Ph. D. Editor-in-chief

  16. LIN28B polymorphisms are associated with central precocious puberty and early puberty in girls

    Directory of Open Access Journals (Sweden)

    Sung Won Park

    2012-10-01

    Full Text Available &lt;B&gt;Purpose:&lt;/B&gt; Single-nucleotide polymorphism (SNP markers within &lt;i&gt;LIN28B&lt;/i&gt; have been reported to be related to the timing of pubertal growth. However, no study has investigated the frequency of genetic markers in girls with precocious puberty (PP or early puberty (EP. This study aimed to determine the frequency of putative genetic markers in girls with PP or EP. &lt;B&gt;Methods:&lt;/B&gt; Genomic DNAs were obtained from 77 and 109 girls that fulfilled the criteria for PP and EP, respectively. The controls in this study were 144 healthy volunteers between 20 and 30 years of age. The haplotypes were reconstructed using 11 SNPs of &lt;i&gt;LIN28B&lt;/i&gt;, and haplotype association analysis was performed. The haplotype frequencies were compared. Differences in the clinical and laboratory parameters were analyzed according to the haplotype dosage. &lt;B&gt;Results:&lt;/B&gt; Eleven SNPs in &lt;i&gt;LIN28B&lt;/i&gt; were all located in a block that was in linkage disequilibrium. The haplotype could be reconstructed using 2 representative SNPs, rs4946651 and rs369065. The AC haplotype was less frequently observed in the PP group than in the controls (0.069 vs. 0.144, &lt;I&gt;P&lt;/I&gt;=0.010. The trend that girls with non-AC haplotypes tended to have earlier puberty onset (&lt;I&gt;P&lt;/I&gt;=0.037 was illustrated even in the EP+PP patient group by Kaplan-Meier analysis. &lt;B&gt;Conclusion:&lt;/B&gt; The results of the present study showed that non-AC haplotypes of &lt;i&gt;LIN28B&lt;/i&gt;had a significant association with PP in girls.

  17. Lin28a Is Dormant, Functional, and Dispensable During Mouse Oocyte-to-Embryo Transition

    Czech Academy of Sciences Publication Activity Database

    Flemr, Matyáš; Moravec, Martin; Libová, Veronika; Sedláček, Radislav; Svoboda, Petr

    2014-01-01

    Roč. 90, č. 6 (2014), s. 1-9 ISSN 0006-3363 R&D Projects: GA MŠk LH13084; GA MŠk(CZ) LM2011032; GA ČR(CZ) GBP305/12/G034 Institutional support: RVO:68378050 Keywords : early development * genome activation * guinea pigs * Let-7 * LIN28 * mice * microRNA * oocyte * rats * RNAi * rodents * transgenic/ knockout model * voles * zygote Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.318, year: 2014

  18. Core competencies for scientific editors of biomedical journals: consensus statement.

    Science.gov (United States)

    Moher, David; Galipeau, James; Alam, Sabina; Barbour, Virginia; Bartolomeos, Kidist; Baskin, Patricia; Bell-Syer, Sally; Cobey, Kelly D; Chan, Leighton; Clark, Jocalyn; Deeks, Jonathan; Flanagin, Annette; Garner, Paul; Glenny, Anne-Marie; Groves, Trish; Gurusamy, Kurinchi; Habibzadeh, Farrokh; Jewell-Thomas, Stefanie; Kelsall, Diane; Lapeña, José Florencio; MacLehose, Harriet; Marusic, Ana; McKenzie, Joanne E; Shah, Jay; Shamseer, Larissa; Straus, Sharon; Tugwell, Peter; Wager, Elizabeth; Winker, Margaret; Zhaori, Getu

    2017-09-11

    Scientific editors are responsible for deciding which articles to publish in their journals. However, we have not found documentation of their required knowledge, skills, and characteristics, or the existence of any formal core competencies for this role. We describe the development of a minimum set of core competencies for scientific editors of biomedical journals. The 14 key core competencies are divided into three major areas, and each competency has a list of associated elements or descriptions of more specific knowledge, skills, and characteristics that contribute to its fulfillment. We believe that these core competencies are a baseline of the knowledge, skills, and characteristics needed to perform competently the duties of a scientific editor at a biomedical journal.

  19. Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.

    Science.gov (United States)

    Nowak, Jakub Stanislaw; Hobor, Fruzsina; Downie Ruiz Velasco, Angela; Choudhury, Nila Roy; Heikel, Gregory; Kerr, Alastair; Ramos, Andres; Michlewski, Gracjan

    2017-03-01

    Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3'-5' exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a polyuridylation-independent mechanism. Here we reveal that the sequences and structural characteristics of pre-let-7 and pre-miRNA-9 are eliciting two distinct modes of binding to Lin28a. We present evidence that Dis3l2 controls miRNA-9 production. Finally, we show that the constitutive expression of untagged Lin28a during neuronal differentiation in vitro positively and negatively affects numerous other miRNAs. Our findings shed light on the role of Lin28a in differentiating cells and on the ways in which one RNA-binding protein can perform multiple roles in the regulation of RNA processing. © 2017 Nowak et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  20. Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

    International Nuclear Information System (INIS)

    Sokolova, O.S.; Shaburova, O.V.; Pechnikova, E.V.; Shaytan, A.K.; Krylov, S.V.; Kiselev, N.A.; Krylov, V.N.

    2014-01-01

    A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P. aeruginosa phages EL and Lin68 using cryo-electron microscopy and revealed the presence of inner bodies. The shape and positioning of the inner body and the density of the DNA packaging in EL are different from those found in phiKZ and Lin68. This internal organization explains how the shorter EL genome is packed into a large EL capsid, which has the same external dimensions as the capsids of phiKZ and Lin68. The similarity in the structural organization in EL and other phiKZ-like phages indicates that EL is phylogenetically related to other phiKZ-like phages, and, despite the lack of detectable DNA homology, EL, phiKZ, and Lin68 descend from a common ancestor. - Highlights: • We performed a comparative structural study of giant P. aeruginosa phages: EL, Lin68 and phiKZ. • We revealed that the inner body is a common feature in giant phages. • The phage genome size correlates with the overall dimensions of the inner body

  1. Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

    Energy Technology Data Exchange (ETDEWEB)

    Sokolova, O.S., E-mail: sokolova@mail.bio.msu.ru [M.V. Lomonosov Moscow State University, Moscow (Russian Federation); A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Shaburova, O.V. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation); Pechnikova, E.V. [A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Shaytan, A.K. [M.V. Lomonosov Moscow State University, Moscow (Russian Federation); Krylov, S.V. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation); Kiselev, N.A. [A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Krylov, V.N. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation)

    2014-11-15

    A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P. aeruginosa phages EL and Lin68 using cryo-electron microscopy and revealed the presence of inner bodies. The shape and positioning of the inner body and the density of the DNA packaging in EL are different from those found in phiKZ and Lin68. This internal organization explains how the shorter EL genome is packed into a large EL capsid, which has the same external dimensions as the capsids of phiKZ and Lin68. The similarity in the structural organization in EL and other phiKZ-like phages indicates that EL is phylogenetically related to other phiKZ-like phages, and, despite the lack of detectable DNA homology, EL, phiKZ, and Lin68 descend from a common ancestor. - Highlights: • We performed a comparative structural study of giant P. aeruginosa phages: EL, Lin68 and phiKZ. • We revealed that the inner body is a common feature in giant phages. • The phage genome size correlates with the overall dimensions of the inner body.

  2. Foreword from the Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Jon M. Truby

    2012-04-01

    Highness the Emir, Sheikh Hamad bin Khalifa Al Thani, for this vision. I am grateful to all of those involved in the production of this and future issues, and hope the demands of our readers are met. May the journal continue to be a success. Dr. Jon M. Truby Ph.D, Editor-in-Chief

  3. From Editor vol 11, No.3

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2010-07-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 11, Number: 3. In this issue it is published 3 notes for Editor, 12 articles, 2 book reviews. And this time, 32 authors from 10 different countries are placed. These published articles are from Barbados, Ghana, Iran, Malaysia, Pakistan, Spain, Turkey, United Kingdom, UAE and USA.“Developing and Validation A Usability Evaluation Tools For Distance Education Websites:Persian Version” has sent as Notes for editor section of TOJDE from Iran and written by Soheila HAFEZI, Ahmad FARAHI from Payame Noor University and Soheil Najafi MEHRI, Hosein MAHMOODI from Baqiyatallah Medical Sciences University, Tehran.. Their paper involves that he content validity index was measured by set of ten experts, who evaluated each item individually. According to CVI, the final version of instrument was composed of 40 questions divided into 8 domains: Navigation, Functionality, Feedback, Control, Language, Consistency, Error prevention and correction, and Visual clarity. CVI score for each phrase was more than 0.75. According to our findings, this instrument has enough validity to apply in evaluation usability of educational websites of Persian distance education websites. However, instrument reliability can be measured in further study. The second notes for editor is titled as “A Critical Analysis Of Managerial Skills Competencies Of Secondary School Heads Trained Through Distance Mode of Allama Iqbal Open University” which is written by Muhammad AKHLAQ from Preston University, Islamabad, PAKISTAN and SHAZIA MUNAWAR SULEHRI from Ministry of Education, PAKISTAN. They mentioned in their paper to analyze the managerial skills competencies of secondary schools heads trained through distance mode of education in Pakistan. For this purpose a sample 300 secondary school teachers and 100 secondary schools head-teachers trained through distance mode and working in the Federal Government

  4. EDITORIAL: New Editor-in-Chief for Nanotechnology New Editor-in-Chief for Nanotechnology

    Science.gov (United States)

    Couzin, Nina

    2009-01-01

    Nanotechnology is proud to announce the appointment of Professor Mark Reed, Yale University, as the new Editor-in-Chief from January 2009. Mark Reed holds the Harold Hodgkinson Chair of Engineering and Applied Science at Yale University. He has made significant contributions in the areas of quantum dots, electronic transport in nanoscale and mesoscopic systems, artificially structured materials and devices, and molecular electronics. Professor Reed has been associated with the journal as an Editorial Board member for a number of years and we are delighted that he has agreed to take on the scientific leadership of the journal in its 20th year. We also take the opportunity to thank Professor Mark Welland, Cambridge University, for his work as Editor-in-Chief since 2001, and for presiding over the re-launch and remarkable growth of the journal since then. Nanotechnology is unique in that it was the first peer-reviewed journal in the area of nanoscience, the first issue appearing in 1990. Since then it has established a distinguished publication record and has become a leading journal covering all aspects of nanoscale science and technology, as well as specializing in in-depth, comprehensive articles not seen in letter format journals. Published weekly and featuring subject sections, the journal is truly multidisciplinary in nature and is an excellent medium to quickly deliver your research results to readers worldwide. Nanotechnology is proud to be offering some of the fastest publication times around (less than three months on average from receipt to online publication). We offer free online access to all published papers for 30 days, ensuring that anyone with access to the internet will be able to read your paper. We were also the first journal to give our authors the opportunity to communicate their research to a wider audience through nanotechweb.org and other IOP websites. See the journal's homepage at www.iop.org/Journals/nano for more details. We are looking

  5. LEDWIRE: A Versatile Networking Platform for Smart LED Lighting Applications Using LIN-Bus and WSNs

    Directory of Open Access Journals (Sweden)

    Dimitrios D. Piromalis

    2016-05-01

    Full Text Available In this paper, the architecture of a versatile networking and control platform for Light-Emitting Diode (LED lighting applications is presented, based on embedded wireless and wired networking technologies. All the possible power and control signals distribution topologies of the lighting fixtures are examined with particular focus on dynamic lighting applications with design metrics as the cost, the required wiring installation expenses and maintenance complexity. The proposed platform is optimized for applications where the grouping of LED-based lighting fictures clusters is essential, as well as their synchronization. With such an approach, the distributed control and synchronization of LED lighting fixtures' clusters is performed through a versatile network that uses the single wire Local Interconnect Network (LIN bus. The proposed networking platform is presented in terms of its physical layer architecture, its data protocol configuration, and its functionality for smart control. As a proof of concept, the design of a LED lighting fixture together with a LIN-to-IEEE802.15.4/ZigBee data gateway is presented.

  6. Writing GNU Emacs Extensions Editor Customizations and Creations with Lisp

    CERN Document Server

    Glickstein, Bob

    2010-01-01

    Yes, it is possible to be all things to all people, if you're talking about the Emacs editor. As a user, you can make any kind of customization you want, from choosing the keystrokes that invoke your favorite commands to creating a whole new work environment that looks like nothing ever developed before. It's all in Emacs Lisp -- and in this short but fast-paced book. GNU Emacs is more than an editor; it's a programming environment, a communications package, and many other things. To provide such a broad range of functions, it offers a full version of the Lisp programming language

  7. Predicting Post-Editor Profiles from the Translation Process

    DEFF Research Database (Denmark)

    Singla, Karan; Orrego-Carmona, David; Gonzales, Ashleigh Rhea

    2014-01-01

    The purpose of the current investigation is to predict post-editor profiles based on user behaviour and demographics using machine learning techniques to gain a better understanding of post-editor styles. Our study extracts process unit features from the CasMaCat LS14 database from the CRITT...... of translation process features. The classification and clustering of participants resulting from our study suggest this type of exploration could be used as a tool to develop new translation tool features or customization possibilities....

  8. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors' Network.

    Science.gov (United States)

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Cas, Livio Dei; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; Filipiak, Krzysztof J; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J J; Varga, Albert; Lüscher, Thomas F

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability -, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors' Network of the European Society of Cardiology. Copyright © 2017. Publicado por Masson Doyma México S.A.

  9. Announcement: New Editor-in-Chief Robert C. Kennicutt

    Science.gov (United States)

    Abt, Helmut A.

    1999-05-01

    Effective 1999 July 1, all new manuscripts for Part 1 of The Astrophysical Journal and The Astrophysical Journal Supplement Series should be sent to Dr. Robert C. Kennicutt, Editor-in-Chief The Astrophysical Journal Steward Observatory University of Arizona Tucson, AZ 85721-0065 The other means of contact are telephone, (520) 621-5145 FAX, (520) 621-5153 and e-mail, apj@as.arizona.edu. For express packages please use the street address of 933 North Cherry Avenue. Dr. Kennicutt will be assisted by several of my loyal coworkers, who will move across the street. Manuscripts received before July 1 will be handled by the current editor until most of their problems have been resolved, at which point the remainder will be sent to Dr. Kennicutt's office. Manuscripts for the Letters should, as before, be sent directly to Dr. Alex Dalgarno at the Center for Astrophysics in Cambridge, MA. We are fortunate that a person with as much experience in research and proven good judgment as Dr. Kennicutt is willing to accept this difficult and time-consuming responsibility. He will be only the seventh Managing Editor or Editor-in-Chief that this Journal has had in its 104 years. Please give him the cooperation and help that you have given the current editor. It has been my privilege to work for 28 years with many of the best astrophysicists in the world and to publish their papers. This was done with the help of the AAS Publications Board and AAS officers, the efforts of Peter Boyce and Evan Owens who made the on-line edition of the Journal possible, three Associate Editors, a score of Scientific Editors, a hardworking staff of six in Tucson, up to 25 production controllers and manuscript editors at the University of Chicago Press, and the thousands of astronomers throughout the world who served as referees. The original masthead called this journal ``An International Review of Spectroscopy and Astronomical Physics.'' That subtitle is no longer appropriate because we do not publish

  10. Announcement: New Editor-In Robert C. Kennicutt

    Science.gov (United States)

    Abt, Helmut A.

    1999-06-01

    Effective 1999 July 1, all new manuscripts for Part 1 of The Astrophysical Journal and The Astrophysical Journal Supplement Series should be sent to Dr. Robert C. Kennicutt, Editor-in-Chief The Astrophysical Journal Steward Observatory University of Arizona Tucson, AZ 85721-0065 The other means of contact are telephone, (520) 621-5145 FAX, (520) 621-5153 and e-mail, apj@as.arizona.edu. For express packages please use the street address of 933 North Cherry Avenue. Dr. Kennicutt will be assisted by several of my loyal coworkers, who will move across the street. Manuscripts received before July 1 will be handled by the current editor until most of their problems have been resolved, at which point the remainder will be sent to Dr. Kennicutt's office. Manuscripts for the Letters should, as before, be sent directly to Dr. Alex Dalgarno at the Center for Astrophysics in Cambridge, MA. We are fortunate that a person with as much experience in research and proven good judgment as Dr. Kennicutt is willing to accept this difficult and time-consuming responsibility. He will be only the seventh Managing Editor or Editor-in-Chief that this Journal has had in its 104 years. Please give him the cooperation and help that you have given the current editor. It has been my privilege to work for 28 years with many of the best astrophysicists in the world and to publish their papers. This was done with the help of the AAS Publications Board and AAS officers, the efforts of Peter Boyce and Evan Owens who made the on-line edition of the Journal possible, three Associate Editors, a score of Scientific Editors, a hardworking staff of six in Tucson, up to 25 production controllers and manuscript editors at the University of Chicago Press, and the thousands of astronomers throughout the world who served as referees. The original masthead called this journal ``An International Review of Spectroscopy and Astronomical Physics.'' That subtitle is no longer appropriate because we do not publish

  11. Announcement: New Editor-In-Chief, Robert C. Kennicutt, Jr.

    Science.gov (United States)

    Abt, Helmut A.

    1999-06-01

    Effective 1999 July 1, all new manuscripts for Part 1 of The Astrophysical Journal and The Astrophysical Journal Supplement Series should be sent to Dr. Robert C. Kennicutt, Jr., Editor-in-Chief The Astrophysical Journal Steward Observatory University of Arizona Tucson, AZ 85721-0065 The other means of contact are telephone, (520) 621-5145 FAX, (520) 621-5153 and e-mail, apj@as.arizona.edu. For express packages please use the street address of 933 North Cherry Avenue. Dr. Kennicutt will be assisted by several of my loyal coworkers, who will move across the street. Manuscripts received before July 1 will be handled by the current editor until most of their problems have been resolved, at which point the remainder will be sent to Dr. Kennicutt's office. Manuscripts for the Letters should, as before, be sent directly to Dr. Alex Dalgarno at the Center for Astrophysics in Cambridge, MA. We are fortunate that a person with as much experience in research and proven good judgment as Dr. Kennicutt is willing to accept this difficult and time-consuming responsibility. He will be only the seventh Managing Editor or Editor-in-Chief that this Journal has had in its 104 years. Please give him the cooperation and help that you have given the current editor. It has been my privilege to work for 28 years with many of the best astrophysicists in the world and to publish their papers. This was done with the help of the AAS Publications Board and AAS officers, the efforts of Peter Boyce and Evan Owens who made the on-line edition of the Journal possible, three Associate Editors, a score of Scientific Editors, a hardworking staff of six in Tucson, up to 25 production controllers and manuscript editors at the University of Chicago Press, and the thousands of astronomers throughout the world who served as referees. The original masthead called this journal ``An International Review of Spectroscopy and Astronomical Physics.'' That subtitle is no longer appropriate because we do not

  12. Topografia ficcional: a construção do espaço nos manuscritos de Osman Lins

    Directory of Open Access Journals (Sweden)

    Francisco José Gonçalves Lima Rocha

    2013-01-01

    Full Text Available In the construction of the narrative space of his final, unfinished novel, A cabeça levada em triunfo, Osman Lins operates both verbal, with notes planning, as iconically, through drawings. Will try to show that the author’s purpose is to clarify the topography of the work, because it establishes and harmonizes the technical functions - ie, like space, says Osman Lins, “frame” the character – and symbolic means, ie. how the space reflects, like all other elements of the work, the questioning of the head-body dichotomy.

  13. Letters to the Editor: Tattooing gone wrong | Hampton | South African ...

    African Journals Online (AJOL)

    South African Journal of Surgery. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 55, No 1 (2017) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Letters to the Editor: Tattooing gone wrong. M I Hampton ...

  14. Kamide reflects on JGR and the role of editor

    Science.gov (United States)

    Woods, Peter

    After serving the space physics community for more than 11 years, Y. Kamide of the Solar-Terrestrial Environment Laboratory at Nagoya University in Toyokawa, Japan, retired as editor of the Journal of Geophysical Research-Space Physics for the Asian/Pacific region. He had been a JGR editor since AGU first opened two editorial offices in Europe and the Asian/Pacific region in 1989. Even as the initial JGR editor in Asia, Kamide was not new to AGU editorial business. Before accepting the JGR position, Kamide served 3 years as the editor in Japan for Geophysical Research Letters.According to Kamide, over the last 5 years, the number of high-quality submissions to JGR in the Asian/Pacific region has increased dramatically, by a factor of 2.5. This increase came mostly from the younger generation of scientists, which bodes well for the future of JGR and space physics in general. Together with the substantial contributions to JGR from the European community, this achievement has been recognized by AGU as proof that JGR is truly an international journal of the highest editorial standards.

  15. Predatory Journals and Perished Articles; a Letter to Editor

    OpenAIRE

    Narimani, Mashallah; Dadkhah, Mehdi

    2017-01-01

    In recent years, academic publishing has been faced with many destructive phenomena. “Predatory publishers” (or journals) are one challenge for  cholarly publishing. This term was introduced to academic societies for the first time by Jeffrey Beall in 2010. This letter to editor is about predatory journals and perished articles in the field of emergency medicine.

  16. Publishing in Educational Psychology Journals: Comments from Editors

    Science.gov (United States)

    Nihalani, Priya K.; Mayrath, Michael C.

    2008-01-01

    The following paper emphasizes the importance of publishing and learning how to publish in educational psychology journals. We have compiled a set of recommendations based on advice from editors in the field and several other sources on how to publish. Additionally, this paper provides a step-by-step guide that graduate students and junior faculty…

  17. Pandangan Editor Surat Kabar Indonesia Dan Malaysia Terhadap Jurnalisme Multikultural

    OpenAIRE

    Junaidi, Junaidi

    2010-01-01

    Both Indonesia and Malaysia are characterized as multicultural society. In multiculturalsociety mass media plays a singnifant role in keeping peaceful condition. Journalistic activitiesgreatly influences the coverage related to multicultural issues. Multicultural journalism is ajournalistic activity which consider multicultural society's interest in keeping peaceful condition.This article aims to know Indonesian dan Malaysian newspaper editors' views towardmulticultural coverage. The study of...

  18. Most Business Editors Find Journalism Graduates Still Unprepared

    Science.gov (United States)

    Pardue, Mary Jane

    2014-01-01

    In 2002, a study was published in "Newspaper Research Journal" that explored the preparedness of graduating journalism students to cover business news. In 2012, a follow-up survey of business editors at the nation's daily newspapers was done to see whether progress had been made in the training of journalism students for the…

  19. Ethical Guideline to Authors,Editors,and Reviewers

    Institute of Scientific and Technical Information of China (English)

    Editorial office of CHM

    2016-01-01

    Drug products are specific goods with safety and effectiveness in medical health case.All of researchers(authors),reviewers,and editors must abide by medical ethical obligation,and also must deter to the ethical obligation for publication.These guidelines are offered as ethical

  20. Editor's note Recent instances of author misconduct in Pramana

    Indian Academy of Sciences (India)

    The exploding nature of the amount of available scientific information in- deed makes it a very demanding job for referees and editors to catch possible cases of plagiarism. While many cases are discovered during the refereeing process, some do slip through it. We are sorry that this has happened for. Pramana in a few ...

  1. Menthor Editor: An Ontology-Driven Conceptual Modeling Platform

    NARCIS (Netherlands)

    Moreira, João Luiz; Sales, Tiago Prince; Guerson, John; Braga, Bernardo F.B; Brasileiro, Freddy; Sobral, Vinicius

    2016-01-01

    The lack of well-founded constructs in ontology tools can lead to the construction of non-intended models. In this demonstration we present the Menthor Editor, an ontology-driven conceptual modelling platform which incorporates the theories of the Unified Foundational Ontology (UFO). We illustrate

  2. pedigreejs: a web-based graphical pedigree editor.

    Science.gov (United States)

    Carver, Tim; Cunningham, Alex P; Babb de Villiers, Chantal; Lee, Andrew; Hartley, Simon; Tischkowitz, Marc; Walter, Fiona M; Easton, Douglas F; Antoniou, Antonis C

    2018-03-15

    The collection, management and visualization of clinical pedigree (family history) data is a core activity in clinical genetics centres. However, clinical pedigree datasets can be difficult to manage, as they are time consuming to capture, and can be difficult to build, manipulate and visualize graphically. Several standalone graphical pedigree editors and drawing applications exist but there are no freely available lightweight graphical pedigree editors that can be easily configured and incorporated into web applications. We developed 'pedigreejs', an interactive graphical pedigree editor written in JavaScript, which uses standard pedigree nomenclature. Pedigreejs provides an easily configurable, extensible and lightweight pedigree editor. It makes use of an open-source Javascript library to define a hierarchical layout and to produce images in scalable vector graphics (SVG) format that can be viewed and edited in web browsers. The software is freely available under GPL licence (https://ccge-boadicea.github.io/pedigreejs/). tjc29@cam.ac.uk. Supplementary data are available at Bioinformatics online.

  3. Cover Letter Dear Editor, Please find enclosed a paper entitled ...

    African Journals Online (AJOL)

    Ajamein

    Dear Editor,. Please find enclosed a paper entitled ' Intrinsic Kinetics of Fischer- Tropsch Synthesis Over a. Promoted Iron Catalyst '. I am submitting to your journal to be considered for publication as a research paper in Bulletin of the Chemical Society of Ethiopia. The manuscript has not been previously published, is not ...

  4. From the editors: Finalizing a stage Editorial: Finalizando una etapa

    Directory of Open Access Journals (Sweden)

    Pep Simo

    2007-07-01

    Full Text Available This editorial briefly summarizes the work done by the editorial team of Intangible Capital in the last three years. We also inform the readers of Intagible Capital about the changes in the editorial position.En la presente editorial se sintetiza el trabajo de los últimos tres años y se presenta el relevo en el cargo de editor.

  5. Forward by Guest Editors | Potgieter | African Journal on Conflict ...

    African Journals Online (AJOL)

    African Journal on Conflict Resolution. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 15, No 3 (2015) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Forward by Guest Editors. Cheryl Potgieter, Paulus ...

  6. EDITORIAL: Outgoing Editor-in-Chief Outgoing Editor-in-Chief

    Science.gov (United States)

    Hauptmann, Peter

    2012-01-01

    I started in 2002 as Editor-in-Chief of a well established journal—MST (Measurement Science and Technology). It was a time when modern means of communication offered new opportunities for the scientific community—for all scientists and engineers whether at universities, in industry or at other institutions—to access better quality information in a shorter time. This development helped us to be more efficient in our daily scientific work and to anticipate new trends faster than before. A flood of information was created by different search engines. A few online journals or journals published in emerging countries with a similar profile to MST appeared on the market. MST had to provide new answers in response to these developments. In 2002 I postulated two requirements to the journal. Firstly, the publisher has to be up to date. My impression over the years has been that IOPP is excellently organized. That has made it easier for the board members and all our reviewers to concentrate on the scientific aspects of our input to the journal. During all my visits to Bristol or my contacts with the IOPP staff I always met very professional and enthusiastic staff members. They have not only supported and encouraged the ideas and initiatives of the Editorial Board members, but they have also worked hard on establishing one of the most effective journal operations in the field of measurement science and technology. Many authors are well aware of this. Thus I am able to declare that the first requirement for a successful journal has been met. Secondly, the scientific level has to be high and the journal should attract readers from all over the world. This task was the responsibility of the Editorial Board members and of myself. Our strategy was on the one hand to ensure continuity in MST but on the other hand to be open to new trends and developments. Examples of these new aspects of the journal are fields like micro- and nanometrology, measurement techniques for

  7. Magazine Editors and the Writing Process: An Analysis of How Editors Work with Staff and Free-Lance Writers.

    Science.gov (United States)

    Schierhorn, Ann B.; Endres, Kathleen L.

    Editors of business and consumer magazines chosen by a random sample were asked in a mail survey what method they used in working with staff writers and free-lance writers. They were asked how they work with writers in the five stages of the writing process--idea, reporting, organizing, writing and rewriting. The first mailing to consumer…

  8. Traitement statistique des distorsions non-linéaires pour la restauration des enregistrements sonores.

    OpenAIRE

    Picard , Guillaume

    2006-01-01

    L'objet de la thèse est l'étude, la modélisation et le traitement des distorsions non linéaires sonores, pour lesquelles les techniques actuelles s'avèrent impuissantes. L'approche retenue consiste à représenter, globalement, à la fois le signal audio à restaurer et le processus de distorsion, dans le cadre d'un modèle statistique. Cette approche présente un bon compromis entre une souhaitable généricité -possibilité de traiter à l'aide d'une méthode globale plusieurs types de distorsions- et...

  9. Reduction of EMC Emissions in Mixed Signal Integrated Circuits with Embedded LIN Driver

    Directory of Open Access Journals (Sweden)

    P. Hartl

    2016-06-01

    Full Text Available This paper describes several methods for reduction of electromagnetic emissions (EME of mixed signal integrated circuits (IC. The focus is on the impact that a LIN bus communication block has on a complex IC which contains analog blocks, noisy digital block, micro-core (µC and several types of memories. It is used in an automotive environment, where EMC emission reduction is one of the key success factors. Several proposed methods for EME reduction are described and implemented on three test chips. These methods include current consumption reduction, internal on-chip decoupling, ground separation and different linear voltage regulator topologies. Measurement results of several fabricated test chips are shown and discussed.

  10. QUANTUM INSPIRED PARTICLE SWARM COMBINED WITH LIN-KERNIGHAN-HELSGAUN METHOD TO THE TRAVELING SALESMAN PROBLEM

    Directory of Open Access Journals (Sweden)

    Bruno Avila Leal de Meirelles Herrera

    2015-12-01

    Full Text Available ABSTRACT The Traveling Salesman Problem (TSP is one of the most well-known and studied problems of Operations Research field, more specifically, in the Combinatorial Optimization field. As the TSP is a NP (Non-Deterministic Polynomial time-hard problem, there are several heuristic methods which have been proposed for the past decades in the attempt to solve it the best possible way. The aim of this work is to introduce and to evaluate the performance of some approaches for achieving optimal solution considering some symmetrical and asymmetrical TSP instances, which were taken from the Traveling Salesman Problem Library (TSPLIB. The analyzed approaches were divided into three methods: (i Lin-Kernighan-Helsgaun (LKH algorithm; (ii LKH with initial tour based on uniform distribution; and (iii an hybrid proposal combining Particle Swarm Optimization (PSO with quantum inspired behavior and LKH for local search procedure. The tested algorithms presented promising results in terms of computational cost and solution quality.

  11. José Lins do Rego: um guia brasileiro de Israel

    Directory of Open Access Journals (Sweden)

    Glauber Pereira Quintão

    2010-03-01

    Full Text Available Este artigo procura analisar, de forma crítica, o livro de José Lins do Rego, Roteiro de Israel, 1955. Busca-­se destacar duas facetas suplementares: a de um olhar poético e a de uma preocupação ético-política lançados pelo escritor sobre a construção do novo Estado de Israel. Observa-­se também uma relação entre os signos da modernidade e das histórias arcaica judaicas. Para isso, usa-­se o conceito de palimpsesto, de Gerard Genette, e de flâneur, de Walter Benjamim.

  12. Lin28B promotes Müller glial cell de-differentiation and proliferation in the regenerative rat retinas

    Science.gov (United States)

    Tao, Zui; Zhao, Chen; Jian, Qian; Gillies, Mark; Xu, Haiwei; Yin, Zheng Qin

    2016-01-01

    Retinal regeneration and repair are severely impeded in higher mammalian animals. Although Müller cells can be activated and show some characteristics of progenitor cells when injured or under pathological conditions, they quickly form gliosis scars. Unfortunately, the basic mechanisms that impede retinal regeneration remain unknown. We studied retinas from Royal College of Surgeon (RCS) rats and found that let-7 family molecules, let-7e and let-7i, were significantly overexpressed in Müller cells of degenerative retinas. It demonstrated that down-regulation of the RNA binding protein Lin28B was one of the key factors leading to the overexpression of let-7e and let-7i. Lin28B ectopic expression in the Müller cells suppressed overexpression of let-7e and let-7i, stimulated and mobilized Müller glia de-differentiation, proliferation, promoted neuronal commitment, and inhibited glial fate acquisition of de-differentiated Müller cells. ERG recordings revealed that the amplitudes of a-wave and b-wave were improved significantly after Lin28B was delivered into the subretinal space of RCS rats. In summary, down-regulation of Lin28B as well as up-regulation of let-7e and let-7i may be the main factors that impede Müller cell de-differentiation and proliferation in the retina of RCS rats. PMID:27384999

  13. Changes in Editorial board Rhinology, Prof. Valerie Lund demits office as Editor in Chief of Rhinology

    NARCIS (Netherlands)

    Fokkens, W. J.

    2014-01-01

    At the Editorial Board Meeting of Rhinology Valerie Lund indicated that she has decided to emit office as Editor in Chief of Rhinology. She became a member of the editorial board in 1993, a co-editor with Prof. Bert Huizing in 1999 and Editor in Chief in 2004. She leaves with our grateful thanks for

  14. PREFACE: Introductory remarks from the Editors Introductory remarks from the Editors

    Science.gov (United States)

    Knobloch, E.; Meseguer, A.; Marques, F.

    2012-06-01

    The local organizers of the 4th BIFD (Bifurcations and Instabilities in Fluid Dynamics) Symposium held in Barcelona on 18-21 July 2011 would like to thank the editors of Fluid Dynamics Research for offering us the opportunity of publishing a peer-reviewed special issue of the journal with a selection of the contributions presented at this conference. We thank both the authors and the referees for working with us on the rather tight schedule necessary to release the issue within one year of the date of the conference. We also thank the invited speakers, B Eckhardt, L Tuckerman, and J M Vega, for contributing keynote papers to this special issue. The series of BIFD symposia started as a small workshop in Madeira, Portugal, in 2004 with no more than 20 participants. This number increased rapidly during the second and third symposia held in 2006 (Denmark) and 2009 (United Kingdom), with 40 and 110 participants, respectively. The 4th BIFD symposium has consolidated this event as one of the leading conferences in hydrodynamic stability, with nearly 200 participants from around the world. The main goal of this conference is to bring together scientists and engineers from different disciplines directly or indirectly related to fluid dynamics, bifurcation theory and hydrodynamic stability theory. The conference covered many research areas within the aforementioned fields, ranging from thermal, shear and centrifugal flows to biofluids, films, drops, viscoelastic flows and magnetohydrodynamics. The structure of the conference, with invited plenary talks and focused sessions, helped the participants find their home in the conference and share state-of-the-art knowledge within the field of hydrodynamic instabilities. The financial support from MICINN (Spanish Ministry of Science and Innovation, Grant no FIS2009-08065-E) and UPC (Universitat Politècnica de Catalunya) is greatly appreciated. The local organizers would also like to thank ETSAB (Barcelona School of Architecture

  15. [Analysis of acid rain characteristics of Lin'an Regional Background Station using long-term observation data].

    Science.gov (United States)

    Li, Zheng-Quan; Ma, Hao; Mao, Yu-Ding; Feng, Tao

    2014-02-01

    Using long-term observation data of acid rain at Lin'an Regional Background Station (Lin'an RBS), this paper studied the interannual and monthly variations of acid rain, the reasons for the variations, and the relationships between acid rain and meteorological factors. The results showed that interannual variation of acid rain at Lin'an RBS had a general increasing trend in which there were two obvious intensifying processes and two distinct weakening processes, during the period ranging from 1985 to 2012. In last two decades, the monthly variation of acid rain at Lin'an RBS indicated that rain acidity and frequency of severe acid rain were increasing but the frequency of weak acid rain was decreasing when moving towards bilateral side months of July. Acid rain occurrence was affected by rainfall intensity, wind speed and wind direction. High frequency of severe acid rain and low frequency of weak acid rain were on days with drizzle, but high frequency of weak acid rain and low frequency of severe acid rain occurred on rainstorm days. With wind speed upgrading, the frequency of acid rain and the proportion of severe acid rain were declining, the pH value of precipitation was reducing too. Another character is that daily dominant wind direction of weak acid rain majorly converged in S-W section ,however that of severe acid rain was more likely distributed in N-E section. The monthly variation of acid rain at Lin'an RBS was mainly attributed to precipitation variation, the increasing and decreasing of monthly incoming wind from SSE-WSW and NWN-ENE sections of wind direction. The interannual variation of acid rain could be due to the effects of energy consumption raising and significant green policies conducted in Zhejiang, Jiangsu and Shanghai.

  16. Editor for Remote Database used in ATLAS Trigger/DAQ

    CERN Document Server

    Meessen, C; Valenta, J

    2006-01-01

    The poster gives brief summary of the ATLAS T/DAQ system, then it introduces the RDB database and describes the RDB Editor application, including its internal structure, GUI features, etc. The RDB Editor is an easy-to-use Java application which allows simple navigation between huge number of objects stored in the RDB. It supports bookmarks, histories, etc. in the way usual in the web browsers. Moreover, it is possible to enhance the application by specialized (graphical) viewers for objects of particular class which will allow the user to see, for example, details that are hard to spot in textual view. As an example of such a plug-in, viewer for EFD_Configuration class was developed.

  17. Developing Media Module Proposed to Editor in Editorial Division

    Science.gov (United States)

    Kristanto, A.; Mustaji; Mariono, A.; Sulistiowati; Nuryati, D. W.

    2018-01-01

    In this era of technology in Indonesia, various publishers introduce themselves and participate in advancing the quality of education through the publication of various books as the learning sources. One of the publishers is PT. JP Press. In compiling the learning sources, we found some problems that are left unresolved by the editor. The purpose of this research is to overcome the problems that exist in PT. JP Press by developing media module. This development research uses the ADDIE model. The types of data used in this study are qualitative and quantitative data obtained based on the results of structured interviews with material experts and media experts, as well as the editorial response questionnaire provided for individual try-out and small group try-out. Therefore, it can be concluded that the medium of elementary school supplementary module proposed to the editors of PT. JP Press is valuable to be used in the teaching and learning activities.

  18. Journalism Education 2016 Vol 5(2): Guest Editor

    OpenAIRE

    Fowler-Watt, Karen

    2016-01-01

    “It’s the story that matters! Teaching journalism’s storytellers” Special Edition of Journalism Education Guest Editor: Karen Fowler-Watt, Bournemouth University, UK. Storytelling is the journalist’s craft skill. Shaped by the tenets of objectivity and accuracy, the news narrative informs the debate and brings us the human stories. If journalism is a craft, then the story is the journalist’s work of art. In a rapidly changing landscape of technological revolution, shifting business models and...

  19. Handing Over the ATLAS eNews Scientific Editor Task

    CERN Multimedia

    P. Jenni

    2006-01-01

    The ATLAS eNews are now established since many years as a lively source of stories about the construction of our detector as well as the preparations for the physics running to come. The human touch in telling these stories is important, and to stimulate and motivate the article writers to include also this side of our work is one of the tasks for the Scientific Editor of the eNews. Joleen ('Jo') Pater has been the enthusiastic and competent 'skipper' for the last two years keeping the eNews on track. The whole Collaboration owes her a great and very hearty thank-you! Pauline Gagnon has kindly accepted to take up the challenge for the next couple of years. She will have the privilege to be the editor when we will see the first collisions with ATLAS! I wish her all the best for this new task. Outgoing and incoming editors of the ATLAS E-news: Jo Pater (left) and Pauline Gagnon (right)

  20. Statement on Publication Ethics for Editors and Publishers

    Science.gov (United States)

    2016-01-01

    The digitization and related developments in journal editing and publishing necessitate increasing the awareness of all stakeholders of science communication in the emerging global problems and possible solutions. Journal editors and publishers are frequently encountered with the fast-growing problems of authorship, conflicts of interest, peer review, research misconduct, unethical citations, and inappropriate journal impact metrics. While the number of erroneous and unethical research papers and wasteful, or 'predatory', journals is increasing exponentially, responsible editors are urged to 'clean' the literature by correcting or retracting related articles. Indexers are advised to implement measures for accepting truly influential and ethical journals and delisting sources with predatory publishing practices. Updating knowledge and skills of authors, editors and publishers, developing and endorsing recommendations of global editorial associations, and (re)drafting journal instructions can be viewed as potential tools for improving ethics of academic journals. The aim of this Statement is to increase awareness of all stakeholders of science communication of the emerging ethical issues in journal editing and publishing and initiate a campaign of upgrading and enforcing related journal instructions. PMID:27510376

  1. Authors, editors, and the signs, symptoms and causes of plagiarism

    Directory of Open Access Journals (Sweden)

    Karen Shashok

    2011-01-01

    Full Text Available Plagiarism and inadequate citing appear to have reached epidemic proportions in research publication. This article discusses how plagiarism is defined and suggests some possible causes for the increase in the plagiarism disease. Most editors do not have much tolerance for text re-use with inadequate citation regardless of reasons why words are copied from other sources without correct attribution. However, there is now some awareness that re-use of words in research articles to improve the writing or "the English" (which has become a common practice should be distinguished from intentional deceit for the purpose of stealing other authors′ ideas (which appears to remain a very rare practice. Although it has become almost as easy for editors to detect duplicate text as it is for authors to re-use text from other sources, editors often fail to consider the reasons why researchers resort to this strategy, and tend to consider any text duplication as a symptom of serious misconduct. As a result, some authors may be stigmatized unfairly by being labeled as plagiarists. The article concludes with practical advice for researchers on how to improve their writing and citing skills and thus avoid accusations of plagiarism.

  2. Authors, editors, and the signs, symptoms and causes of plagiarism.

    Science.gov (United States)

    Shashok, Karen

    2011-07-01

    Plagiarism and inadequate citing appear to have reached epidemic proportions in research publication. This article discusses how plagiarism is defined and suggests some possible causes for the increase in the plagiarism disease. Most editors do not have much tolerance for text re-use with inadequate citation regardless of reasons why words are copied from other sources without correct attribution. However, there is now some awareness that re-use of words in research articles to improve the writing or "the English" (which has become a common practice) should be distinguished from intentional deceit for the purpose of stealing other authors' ideas (which appears to remain a very rare practice). Although it has become almost as easy for editors to detect duplicate text as it is for authors to re-use text from other sources, editors often fail to consider the reasons why researchers resort to this strategy, and tend to consider any text duplication as a symptom of serious misconduct. As a result, some authors may be stigmatized unfairly by being labeled as plagiarists. The article concludes with practical advice for researchers on how to improve their writing and citing skills and thus avoid accusations of plagiarism.

  3. Authors, editors, and the signs, symptoms and causes of plagiarism

    Science.gov (United States)

    Shashok, Karen

    2011-01-01

    Plagiarism and inadequate citing appear to have reached epidemic proportions in research publication. This article discusses how plagiarism is defined and suggests some possible causes for the increase in the plagiarism disease. Most editors do not have much tolerance for text re-use with inadequate citation regardless of reasons why words are copied from other sources without correct attribution. However, there is now some awareness that re-use of words in research articles to improve the writing or “the English” (which has become a common practice) should be distinguished from intentional deceit for the purpose of stealing other authors’ ideas (which appears to remain a very rare practice). Although it has become almost as easy for editors to detect duplicate text as it is for authors to re-use text from other sources, editors often fail to consider the reasons why researchers resort to this strategy, and tend to consider any text duplication as a symptom of serious misconduct. As a result, some authors may be stigmatized unfairly by being labeled as plagiarists. The article concludes with practical advice for researchers on how to improve their writing and citing skills and thus avoid accusations of plagiarism. PMID:21957412

  4. CMS Configuration Editor: GUI based application for user analysis job

    International Nuclear Information System (INIS)

    Cosa, A de

    2011-01-01

    We present the user interface and the software architecture of the Configuration Editor for the CMS experiment. The analysis workflow is organized in a modular way integrated within the CMS framework that organizes in a flexible way user analysis code. The Python scripting language is adopted to define the job configuration that drives the analysis workflow. It could be a challenging task for users, especially for newcomers, to develop analysis jobs managing the configuration of many required modules. For this reason a graphical tool has been conceived in order to edit and inspect configuration files. A set of common analysis tools defined in the CMS Physics Analysis Toolkit (PAT) can be steered and configured using the Config Editor. A user-defined analysis workflow can be produced starting from a standard configuration file, applying and configuring PAT tools according to the specific user requirements. CMS users can adopt this tool, the Config Editor, to create their analysis visualizing in real time which are the effects of their actions. They can visualize the structure of their configuration, look at the modules included in the workflow, inspect the dependences existing among the modules and check the data flow. They can visualize at which values parameters are set and change them according to what is required by their analysis task. The integration of common tools in the GUI needed to adopt an object-oriented structure in the Python definition of the PAT tools and the definition of a layer of abstraction from which all PAT tools inherit.

  5. PDB Editor: a user-friendly Java-based Protein Data Bank file editor with a GUI.

    Science.gov (United States)

    Lee, Jonas; Kim, Sung Hou

    2009-04-01

    The Protein Data Bank file format is the format most widely used by protein crystallographers and biologists to disseminate and manipulate protein structures. Despite this, there are few user-friendly software packages available to efficiently edit and extract raw information from PDB files. This limitation often leads to many protein crystallographers wasting significant time manually editing PDB files. PDB Editor, written in Java Swing GUI, allows the user to selectively search, select, extract and edit information in parallel. Furthermore, the program is a stand-alone application written in Java which frees users from the hassles associated with platform/operating system-dependent installation and usage. PDB Editor can be downloaded from http://sourceforge.net/projects/pdbeditorjl/.

  6. The XML Metadata Editor of GFZ Data Services

    Science.gov (United States)

    Ulbricht, Damian; Elger, Kirsten; Tesei, Telemaco; Trippanera, Daniele

    2017-04-01

    Following the FAIR data principles, research data should be Findable, Accessible, Interoperable and Reuseable. Publishing data under these principles requires to assign persistent identifiers to the data and to generate rich machine-actionable metadata. To increase the interoperability, metadata should include shared vocabularies and crosslink the newly published (meta)data and related material. However, structured metadata formats tend to be complex and are not intended to be generated by individual scientists. Software solutions are needed that support scientists in providing metadata describing their data. To facilitate data publication activities of 'GFZ Data Services', we programmed an XML metadata editor that assists scientists to create metadata in different schemata popular in the earth sciences (ISO19115, DIF, DataCite), while being at the same time usable by and understandable for scientists. Emphasis is placed on removing barriers, in particular the editor is publicly available on the internet without registration [1] and the scientists are not requested to provide information that may be generated automatically (e.g. the URL of a specific licence or the contact information of the metadata distributor). Metadata are stored in browser cookies and a copy can be saved to the local hard disk. To improve usability, form fields are translated into the scientific language, e.g. 'creators' of the DataCite schema are called 'authors'. To assist filling in the form, we make use of drop down menus for small vocabulary lists and offer a search facility for large thesauri. Explanations to form fields and definitions of vocabulary terms are provided in pop-up windows and a full documentation is available for download via the help menu. In addition, multiple geospatial references can be entered via an interactive mapping tool, which helps to minimize problems with different conventions to provide latitudes and longitudes. Currently, we are extending the metadata editor

  7. LIN28 expression in malignant germ cell tumors down-regulates let-7 and increases oncogene levels

    Science.gov (United States)

    Murray, Matthew J.; Saini, Harpreet K.; Siegler, Charlotte A.; Hanning, Jennifer E.; Barker, Emily M.; van Dongen, Stijn; Ward, Dawn M.; Raby, Katie L.; Groves, Ian J.; Scarpini, Cinzia G.; Pett, Mark R.; Thornton, Claire M.; Enright, Anton J.; Nicholson, James C.; Coleman, Nicholas

    2013-01-01

    Despite their clinico-pathologic heterogeneity, malignant germ-cell-tumors (GCTs) share molecular abnormalities that are likely to be functionally important. In this study, we investigated the potential significance of down-regulation of the let-7 family of tumor-suppressor microRNAs in malignant-GCTs. Microarray results from pediatric and adult samples (n=45) showed that LIN28, the negative-regulator of let-7 biogenesis, was abundant in malignant-GCTs, regardless of patient age, tumor site or histologic subtype. Indeed, a strong negative-correlation existed between LIN28 and let-7 levels in specimens with matched datasets. Low let-7 levels were biologically significant, since the sequence complementary to the 2-7nt common let-7 seed ‘GAGGUA’ was enriched in the 3′untranslated regions of mRNAs up-regulated in pediatric and adult malignant-GCTs, compared with normal gonads (a mixture of germ cells and somatic cells). We identified 27 mRNA targets of let-7 that were up-regulated in malignant-GCT cells, confirming significant negative-correlations with let-7 levels. Among 16 mRNAs examined in a largely independent set of specimens by qRT-PCR, we defined negative-associations with let-7e levels for six oncogenes, including MYCN, AURKB, CCNF, RRM2, MKI67 and C12orf5 (when including normal control tissues). Importantly, LIN28 depletion in malignant-GCT cells restored let-7 levels and repressed all of these oncogenic let-7 mRNA targets, with LIN28 levels correlating with cell proliferation and MYCN levels. Conversely, ectopic expression of let-7e was sufficient to reduce proliferation and down-regulate MYCN, AURKB and LIN28, the latter via a double-negative feedback loop. We concluded that the LIN28/let-7 pathway has a critical pathobiological role in malignant-GCTs and therefore offers a promising target for therapeutic intervention. PMID:23774216

  8. Analysis of a lin-42/period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing

    Directory of Open Access Journals (Sweden)

    Theresa L. B. Edelman

    2016-12-01

    Full Text Available The Caenorhabditis elegans heterochronic gene pathway regulates the relative timing of events during postembryonic development. lin-42, the worm homolog of the circadian clock gene, period, is a critical element of this pathway. lin-42 function has been defined by a set of hypomorphic alleles that cause precocious phenotypes, in which later developmental events, such as the terminal differentiation of hypodermal cells, occur too early. A subset of alleles also reveals a significant role for lin-42 in molting; larval stages are lengthened and ecdysis often fails in these mutant animals. lin-42 is a complex locus, encoding overlapping and nonoverlapping isoforms. Although existing alleles that affect subsets of isoforms have illuminated important and distinct roles for this gene in developmental timing, molting, and the decision to enter the alternative dauer state, it is essential to have a null allele to understand all of the roles of lin-42 and its individual isoforms. To remedy this problem and discover the null phenotype, we engineered an allele that deletes the entire lin-42 protein-coding region. lin-42 null mutants are homozygously viable, but have more severe phenotypes than observed in previously characterized hypomorphic alleles. We also provide additional evidence for this conclusion by using the null allele as a base for reintroducing different isoforms, showing that each isoform can provide heterochronic and molting pathway activities. Transcript levels of the nonoverlapping isoforms appear to be under coordinate temporal regulation, despite being driven by independent promoters. The lin-42 null allele will continue to be an important tool for dissecting the functions of lin-42 in molting and developmental timing.

  9. Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum.

    Science.gov (United States)

    Wefers, Annika K; Lindner, Sven; Schulte, Johannes H; Schüller, Ulrich

    2017-02-01

    LIN28B is a homologue of the RNA-binding protein LIN28A and regulates gene expression during development and carcinogenesis. It is strongly upregulated in a variety of brain tumors, such as medulloblastoma, embryonal tumor with multilayered rosettes (ETMR), atypical teratoid/rhabdoid tumor (AT/RT), or glioblastoma, but the effect of an in vivo overexpression of LIN28B on the developing central nervous system is unknown. We generated transgenic mice that either overexpressed Lin28b in Math1-positive cerebellar granule neuron precursors or in a broad range of Nestin-positive neural precursors. Sections of the cerebellar vermis from adult Math1-Cre::lsl-Lin28b mice had an additional subfissure in lobule IV. Vermes from p0 and p7 Nestin-Cre::lsl-Lin28b mice appeared normal, but we found a pronounced vermal hypersublobulation at p15 and p21 in these mice. Also, the external granule cell layer (EGL) was thicker at p15 than in controls, contained more proliferating cells, and persisted up to p21. Consistently, some Pax6- and NeuN-positive cells were present in the EGL of Nestin-Cre::lsl-Lin28b mice even at p21, and we detected more NeuN-positive granule neuron precursors in the molecular layer (ML) as compared to control. Finally, we found some residual Pax2-positive precursors of inhibitory interneurons in the ML of Nestin-Cre::lsl-Lin28b mice at p21, which have already disappeared in controls. We conclude that while overexpression of LIN28B in Nestin-positive cells does not lead to tumor formation, it results in a protracted development of granule cells and inhibitory interneurons and leads to a hypersublobulation of the cerebellar vermis.

  10. Greetings from the new Editor-in-Chief, Ronald Stambaugh Greetings from the new Editor-in-Chief, Ronald Stambaugh

    Science.gov (United States)

    Stambaugh, Ronald

    2012-04-01

    I am very pleased to join the outstanding leadership team for the journal Nuclear Fusion as Scientific Editor. The journal's high position in the field of fusion energy research derives in no small measure from the efforts of the IAEA team in Vienna, the production and marketing of IOP Publishing, the Board of Editors led by its chairman Mitsuru Kikuchi, the Associate Editor for Inertial Confinement Max Tabak and the outgoing Scientific Editor, Paul Thomas. During Paul's five year tenure submissions have grown by over 40%. The usage of the electronic journal has grown year by year with about 300 000 full text downloads of Nuclear Fusion articles in 2011, an impressive figure due in part to the launch of the full 50 year archive. High quality has been maintained while times for peer review and publishing have been reduced and the journal achieved some of the highest impact factors ever (as high as 4.27). The journal has contributed greatly to building the international scientific basis for fusion. I was privileged to serve from 2003 to 2010 as chairman of the Coordinating Committee for the International Tokamak Physics Activity (ITPA) which published in Nuclear Fusion the first ITER Physics Basis (1999) and its later update (2007). The scientific basis that has been developed to date for fusion has led to the construction of major facilities to demonstrate the production of power-plant relevant levels of fusion reactions. We look forward to the journal continuing to play a key role in the international effort toward fusion energy as these exciting major facilities and the various approaches to fusion continue to be developed. It is clear that Nuclear Fusion maintains its position in the field because of the perceived high quality of the submissions, the refereeing and the editorial processes, and the availability and utility of the online journal. The creation of the Nuclear Fusion Prize, led by the Board of Editors chairman Mitsuru Kikuchi, for the most outstanding

  11. The Lives and Hard Times of Magazine Editors in the Big Apple: A Report on the Society of Magazine Editors' Educators Seminar.

    Science.gov (United States)

    English, John W.

    This report chronicles the first Society of Magazine Editors' educators seminar, which was held in New York from May 13-17, 1974, and was attended by ten journalism faculty. The industry's concerns, as expressed through editors, are paper, printing, postage, people, and profit. The Magazine Publishers Association (MPA) seems mostly concerned with…

  12. In vitro and in vivo antimicrobial activities of seeds of Caesalpinia bonduc (Lin.) Roxb.

    Science.gov (United States)

    Arif, Tasleem; Mandal, T K; Kumar, Naresh; Bhosale, J D; Hole, Archana; Sharma, G L; Padhi, M M; Lavekar, G S; Dabur, Rajesh

    2009-05-04

    Caesalpinia bonduc (Lin.) Roxb. is a known drug in Ayurveda to treat various diseases specifically tumors, cysts and cystic fibrosis (CF). The aim of this study was to assess in vitro as well as in vivo antimicrobial activity of Caesalpinia bonduc seeds. The in vitro antimicrobial activities of seed coat and seed kernel extracts were investigated by microbroth dilution assay. In vivo activities of hydro-alcoholic extracts were investigated in rat models of chronic Pseudomonas aeruginosa pneumonia mimicking that in patients with cystic fibrosis. Various extracts of plant seeds exhibited in vitro antimicrobial activities in a range of 22-350 microg/ml. The extracts also showed activity against methicillin resistant (MR) Staphylococcus aureus and ampicillin resistant (AR) Pseudomonas aeruginosa as in the sensitive strains. In rat model of chronic Pseudomonas aeruginosa pneumonia, hydro-alcoholic extracts of Caesalpinia bonduc seed kernel (CBSK) and Caesalpinia bonduc seed coat (CBSC) were injected subcutaneously in the test groups of animals. The control groups were treated with cortisone and saline. Two weeks after challenge with Pseudomonas aeruginosa, the CBSK treated animals showed a significant bacterial clearance from the lungs (PCaesalpinia bonduc may have the potential to be promising natural medicine, with other forms of treatments, for CF patients with chronic Pseudomonas aeruginosa lung infections.

  13. Solving quantum optimal control problems using Clebsch variables and Lin constraints

    Science.gov (United States)

    Delgado-Téllez, M.; Ibort, A.; Rodríguez de la Peña, T.

    2018-01-01

    Clebsch variables (and Lin constraints) are applied to the study of a class of optimal control problems for affine-controlled quantum systems. The optimal control problem will be modelled with controls defined on an auxiliary space where the dynamical group of the system acts freely. The reciprocity between both theories: the classical theory defined by the objective functional and the quantum system, is established by using a suitable version of Lagrange’s multipliers theorem and a geometrical interpretation of the constraints of the system as defining a subspace of horizontal curves in an associated bundle. It is shown how the solutions of the variational problem defined by the objective functional determine solutions of the quantum problem. Then a new way of obtaining explicit solutions for a family of optimal control problems for affine-controlled quantum systems (finite or infinite dimensional) is obtained. One of its main advantages, is the the use of Clebsch variables allows to compute such solutions from solutions of invariant problems that can often be computed explicitly. This procedure can be presented as an algorithm that can be applied to a large class of systems. Finally, some simple examples, spin control, a simple quantum Hamiltonian with an ‘Elroy beanie’ type classical model and a controlled one-dimensional quantum harmonic oscillator, illustrating the main features of the theory, will be discussed.

  14. Roles and responsibilities of the special-section editor

    KAUST Repository

    Marfurt, Kurt

    2017-10-19

    professionals to demonstrate that value in action. Other advantages include the perspectives provided by such special-section authors, editors, and reviewers that draw in a diverse suite of geoscientists and engineers that truly represent the interpretation community. Where there are advantages, there are also disadvantages. First, the vast majority of special-section editors are “new to the job,” never having served on an editorial board of a peer-reviewed scientific journal. The primary objective of this “From the Editor” note is to clarify the roles and responsibilities of this task. Second, many of the selected reviewers may never have had the opportunity to review a paper for publication. They too are new to the job. The August issue of the From the Editor column (Bui et al., 2017) titled “Qualities of a good reviewer” directly addresses this challenge. In this article, we encourage the reviewers to help the authors to construct a quality, well-referenced paper because many of them, too, are new to the job. The third disadvantage is that the special-section format skews the citation-index metrics. Obviously, if the special-section editors identify a good oral presentation and request the author to develop a full-length paper, the chances of acceptance are higher, thus lowering the citation index score. More on this conundrum will be found in the From the Editor column in the February 2018 issue of Interpretation. The remainder of this short article addresses the issues specific to the special-section editors.

  15. EDITORIAL: Greetings from the new Editor-in-Chief

    Science.gov (United States)

    Bhattacharya, P.

    2004-04-01

    On 1 January, 2004, I assumed the position of Editor-in-Chief of Journal of Physics D: Applied Physics. I will start by saying that I will do my best to justify the confidence of the journal management and publishing staff in my abilities. I was fortunate to have been able to work, as an Editorial Board member, with my predecessor, the previous Editor-in-Chief, Professor Allister Ferguson. Allister has provided a high degree of intellectual stewardship for the journal in the last five years. He has made the job appear a worthy challenge for me. I therefore take this opportunity to thank Allister on behalf of the Editorial Board and publishing staff of the journal. Several other factors contributed to my decision to accept this position. The first is the group of people who actually go about the business of publishing. The Senior Publisher, Nicola Gulley (and her predecessor Sophy Le Masurier); the Managing Editor, Jill Membrey; the Publishing Administrators, Nina Blakesley and Sarah Towell; the Production Editor, Katie Gerrard and their office staff form an amazing group and have managed to make the operation of the journal incredibly efficient. An index of this is the speed with which incoming manuscripts are processed. The average time between the receipt of a manuscript and its web publication, if accepted, is 130 days. This is three to five times shorter than for most other journals. A factor that contributes to this success is a responsive pool of referees that the publishing staff have as a valuable resource. Ultimately, the standard bearers of any journal are the referees. Therefore, a grateful `thank you' is due from all of us at J. Phys. D to all our referees, who diligently perform this honourable task. The Associate Editors of the journal, Professors Lawler, Margaritondo and O'Grady, also provide immense scientific leadership. They help in defining new directions for the journal and in the publishing process. Last, but not least, a remarkable asset of

  16. Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A.

    Science.gov (United States)

    He, Qin; Yang, Shuangyan; Gu, Xiuge; Li, Mengying; Wang, Chunling; Wei, Fulan

    2018-04-19

    Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells derived from dental tissues with multidirectional differentiation potential and excellent self-renewing ability. Recently, long noncoding RNAs (lncRNAs) have been shown to play important roles in MSC osteogenic differentiation. In this study, we found that taurine upregulated gene 1 (TUG1), an evolutionarily conserved and widely present lncRNA was significantly upregulated in osteogenically induced PDLSCs compared to their undifferentiated counterparts. Further investigation demonstrated that the expression of TUG1 was positively correlated with the osteogenic differentiation of PDLSCs following the induction, as evidenced by the increase in cellular alkaline phosphatase (ALP) level, formation of calcium nodules, and the upregulation of several osteogenic-related gene markers such as ALP, osteocalcin (OCN), and runt-related transcription factor 2 (Runx2). Conversely, TUG1 knockdown was demonstrated to inhibit the potential of PDLSCs for osteogenic differentiation. Using bioinformatics analysis, we identified lin-28 homolog A (Lin28A) as a potential target of TUG1 during osteogenic differentiation of PDLSCs. Lin28A was found to be significantly downregulated in TUG1-repressed PDLSCs and contained multiple binding sites for lncRNA TUG1. Moreover, suppression of Lin28A was shown to be able to inhibit osteogenic differentiation and decreased the expression of several osteogenic genes. Taken together, these results could help researchers better understand the mechanism that governs the osteogenic differentiation of PDLSCs, and also serve as a stepping stone for the development of novel therapeutic strategies that can be used to regenerate dental tissues.

  17. PROTOTIPE VIDEO EDITOR DENGAN MENGGUNAKAN DIRECT X DAN DIRECT SHOW

    Directory of Open Access Journals (Sweden)

    Djoni Haryadi Setiabudi

    2004-01-01

    Full Text Available Technology development had given people the chance to capture their memorable moments in video format. A high quality digital video is a result of a good editing process. Which in turn, arise the new need of an editor application. In accordance to the problem, here the process of making a simple application for video editing needs. The application development use the programming techniques often applied in multimedia applications, especially video. First part of the application will begin with the video file compression and decompression, then we'll step into the editing part of the digital video file. Furthermore, the application also equipped with the facilities needed for the editing processes. The application made with Microsoft Visual C++ with DirectX technology, particularly DirectShow. The application provides basic facilities that will help the editing process of a digital video file. The application will produce an AVI format file after the editing process is finished. Through the testing process of this application shows the ability of this application to do the 'cut' and 'insert' of video files in AVI, MPEG, MPG and DAT formats. The 'cut' and 'insert' process only can be done in static order. Further, the aplication also provide the effects facility for transition process in each clip. Lastly, the process of saving the new edited video file in AVI format from the application. Abstract in Bahasa Indonesia : Perkembangan teknologi memberi kesempatan masyarakat untuk mengabadikan saat - saat yang penting menggunakan video. Pembentukan video digital yang baik membutuhkan proses editing yang baik pula. Untuk melakukan proses editing video digital dibutuhkan program editor. Berdasarkan permasalahan diatas maka pada penelitian ini dibuat prototipe editor sederhana untuk video digital. Pembuatan aplikasi memakai teknik pemrograman di bidang multimedia, khususnya video. Perencanaan dalam pembuatan aplikasi tersebut dimulai dengan pembentukan

  18. VIP : A Visual Editor and Compiler for v-Promela

    OpenAIRE

    Kamel, Moataz; Leue, Stefan

    2001-01-01

    We describe the Visual Interface to Promela (VIP) tool that we have recently implemented. VIP supports the visual editing and maintenance of v-Promela models. v-Promela is a visual, object-oriented extension to Promela, the input language to the Spin model checker. We introduce the v-Promela notation as supported by the VIP editor, discuss Promela code generation, and describe the process of property validation for the resulting models. Our discussion centers around two case studies, a call p...

  19. SimDialog: A visual game dialog editor

    OpenAIRE

    Owen, C.; Biocca, F.; Bohil, C.; Conley, J.

    2008-01-01

    SimDialog is a visual editor for dialog in computer games. This paper presents the design of SimDialog, illustrating how script writers and non-programmers can easily create dialog for video games with complex branching structures and dynamic response characteristics. The system creates dialog as a directed graph. This allows for play using the dialog with a state-based cause and effect system that controls selection of non-player character responses and can provide a basic scoring mechanism ...

  20. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    Science.gov (United States)

    Nielsch, Kornelius

    2012-01-01

    On 1 January 2012 I will be assuming the position of Editor-in-Chief of the journal Semiconductor Science and Technology (SST). I am flattered by the confidence expressed in my ability to carry out this challenging job and I will try hard to justify this confidence. The previous Editor-in-Chief, Laurens Molenkamp, University of Würzburg, Germany, has worked tirelessly for the last ten years and has done an excellent job for the journal. Everyone at the journal is profoundly grateful for his leadership and for his achievements In 2012 several new members will join the Editorial Board: Professor Deli Wang (University of California, San Diego) with considerable expertise in semiconductor nanowires, Professor Saskia Fischer (Humboldt University, Berlin, Germany) with a background in semiconductor quantum devices, and Professor Erwin Kessels (Eindhoven University of Technology, Netherlands) with extensive experience in plasma processing of thin films and gate oxides. In particular, I want to express my gratitude to Professor Israel Bar-Joseph (Weizmann Institute of Science, Israel) and Professor Maria Tamargo (The City College of New York, USA), who will leave next year and who have vigorously served the Editorial Board for years. The journal has recently introduced a fast-track option for manuscripts. This option is a high-quality, high-profile outlet for new and important research across all areas of semiconductor research. Authors can expect to receive referee reports in less than 20 days from submission. Once accepted, you can expect the articles to be online within two or three weeks from acceptance and to be published in print in less than a month. Furthermore, all fast-track communications published in 2011 will be free to read for ten years. More detailed information on fast-track publication can be found on the following webpage: http://iopscience.iop.org/0268-1242/page/Fast track communications It is encouraging to see that since the journal introduced pre

  1. A role for the malignant brain tumour (MBT domain protein LIN-61 in DNA double-strand break repair by homologous recombination.

    Directory of Open Access Journals (Sweden)

    Nicholas M Johnson

    Full Text Available Malignant brain tumour (MBT domain proteins are transcriptional repressors that function within Polycomb complexes. Some MBT genes are tumour suppressors, but how they prevent tumourigenesis is unknown. The Caenorhabditis elegans MBT protein LIN-61 is a member of the synMuvB chromatin-remodelling proteins that control vulval development. Here we report a new role for LIN-61: it protects the genome by promoting homologous recombination (HR for the repair of DNA double-strand breaks (DSBs. lin-61 mutants manifest numerous problems associated with defective HR in germ and somatic cells but remain proficient in meiotic recombination. They are hypersensitive to ionizing radiation and interstrand crosslinks but not UV light. Using a novel reporter system that monitors repair of a defined DSB in C. elegans somatic cells, we show that LIN-61 contributes to HR. The involvement of this MBT protein in HR raises the possibility that MBT-deficient tumours may also have defective DSB repair.

  2. Comments on ``Anonymous Reviews'' An Editor's View of Anonymous Reviews

    Science.gov (United States)

    Goff, John A.

    I have read with great interest the recent Forum commentaries in Eos by Myrl Beck, Charles Robinove, Robert Criss, and Anne Hofmeister regarding anonymous reviews. I heartily support their position that anonymous reviews should be avoided. I have not written an anonymous review in ages (and regret the few that I did), and have always appreciated and respected greatly anyone who signs a critical review of one of my own papers. However, I would like to add some perspective from the editorial standpoint. I have served as JGR associate editor for 3 years (never anonymously!), and as Eos editor for seismology and tectonophysics for 4. Over the years, I have rejected a fair number of papers, most of those based on anonymous reviews (fortunately, none of the above commentators was one of them). The vast majority of anonymous reviews I received were well considered. While I would wish that all reviews were signed, I don't think we can summarily dismiss the fear that many would have of enmity and reprisal over a critical review. Some of these fears are likely justified. On more than one occasion, have I witnessed overly aggressive responses on the part of authors to anonymous reviews that I considered to be entirely fair and constructive in their criticisms. I do think we need to do all we can to discourage anonymous reviews, but it will be difficult to completely remove that choice from the process.

  3. Editors' welcome, PORTAL, Vol 6, No 2, July 2009

    Directory of Open Access Journals (Sweden)

    Paul Allatson

    2010-01-01

    Full Text Available ‘Post-Mao, Post-Bourdieu: Class and Taste in Contemporary China,’ is a special issue of PORTAL Journal of Multidisciplinary International Studies guest-edited by Yi Zheng (University of Sydney and Stephanie Hemelryk Donald (RMIT University. The special issue explores the relationship between taste, choice and social stratification in contemporary China, and includes a new section, ‘New Perspectives Reports,’ which is intended to showcase opinion and ideas—in this case from the People’s Republic of China, in Mandarin—that complement the main articles. We hope to include this section in future issues of the journal. The guest editors and the PORTAL editorial committee would like to acknowledge that this special issue of is a result of a funding grant from the Australian Research Council, 2003-2005: ‘The Making of Middle-Class Taste: Reading, Tourism, and Educational Choices in Urban China.’ I am also delighted to announce that the PORTAL Editorial Committee has three new members, all from the Faculty of Arts and Social Sciences at the University of Technology, Sydney: Dr Malcolm Angelucci, Dr Beatriz Carrillo, and Dr Fredericka van der Lubbe. Paul Allatson, Editor, PORTAL Journal of Multidisciplinary International Studies.

  4. An editor for the generation and customization of geometry restraints.

    Science.gov (United States)

    Moriarty, Nigel W; Draizen, Eli J; Adams, Paul D

    2017-02-01

    Chemical restraints for use in macromolecular structure refinement are produced by a variety of methods, including a number of programs that use chemical information to generate the required bond, angle, dihedral, chiral and planar restraints. These programs help to automate the process and therefore minimize the errors that could otherwise occur if it were performed manually. Furthermore, restraint-dictionary generation programs can incorporate chemical and other prior knowledge to provide reasonable choices of types and values. However, the use of restraints to define the geometry of a molecule is an approximation introduced with efficiency in mind. The representation of a bond as a parabolic function is a convenience and does not reflect the true variability in even the simplest of molecules. Another complicating factor is the interplay of the molecule with other parts of the macromolecular model. Finally, difficult situations arise from molecules with rare or unusual moieties that may not have their conformational space fully explored. These factors give rise to the need for an interactive editor for WYSIWYG interactions with the restraints and molecule. Restraints Editor, Especially Ligands (REEL) is a graphical user interface for simple and error-free editing along with additional features to provide greater control of the restraint dictionaries in macromolecular refinement.

  5. A Generic Metadata Editor Supporting System Using Drupal CMS

    Science.gov (United States)

    Pan, J.; Banks, N. G.; Leggott, M.

    2011-12-01

    Metadata handling is a key factor in preserving and reusing scientific data. In recent years, standardized structural metadata has become widely used in Geoscience communities. However, there exist many different standards in Geosciences, such as the current version of the Federal Geographic Data Committee's Content Standard for Digital Geospatial Metadata (FGDC CSDGM), the Ecological Markup Language (EML), the Geography Markup Language (GML), and the emerging ISO 19115 and related standards. In addition, there are many different subsets within the Geoscience subdomain such as the Biological Profile of the FGDC (CSDGM), or for geopolitical regions, such as the European Profile or the North American Profile in the ISO standards. It is therefore desirable to have a software foundation to support metadata creation and editing for multiple standards and profiles, without re-inventing the wheels. We have developed a software module as a generic, flexible software system to do just that: to facilitate the support for multiple metadata standards and profiles. The software consists of a set of modules for the Drupal Content Management System (CMS), with minimal inter-dependencies to other Drupal modules. There are two steps in using the system's metadata functions. First, an administrator can use the system to design a user form, based on an XML schema and its instances. The form definition is named and stored in the Drupal database as a XML blob content. Second, users in an editor role can then use the persisted XML definition to render an actual metadata entry form, for creating or editing a metadata record. Behind the scenes, the form definition XML is transformed into a PHP array, which is then rendered via Drupal Form API. When the form is submitted the posted values are used to modify a metadata record. Drupal hooks can be used to perform custom processing on metadata record before and after submission. It is trivial to store the metadata record as an actual XML file

  6. 29 CFR 793.8 - “News editor.”

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS EXEMPTION OF CERTAIN RADIO AND TELEVISION STATION EMPLOYEES... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He...

  7. DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.

    Science.gov (United States)

    Reddien, Peter W; Andersen, Erik C; Huang, Michael C; Horvitz, H Robert

    2007-04-01

    The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a partial loss-of-function allele of the ced-3 caspase gene. We identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death). dpl-1 encodes the C. elegans homolog of DP, the human E2F-heterodimerization partner. By testing genes known to interact with dpl-1, we identified roles in cell death for four additional genes: efl-1 E2F, lin-35 Rb, lin-37 Mip40, and lin-52 dLin52. mcd-1 encodes a novel protein that contains one zinc finger and that is synthetically required with lin-35 Rb for animal viability. dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death. We propose that the DPL-1 DP, MCD-1 zinc finger, EFL-1 E2F, LIN-35 Rb, LIN-37 Mip40, and LIN-52 dLin52 proteins act together in transcriptional regulation to promote programmed cell death.

  8. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors´ Network

    NARCIS (Netherlands)

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Cas, Livio Dei; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; Filipiak, Krzysztof J.; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J. J.; Varga, Albert; Lüscher, Thomas F.

    2017-01-01

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical

  9. Relevance of the Lin's and Host hydropedological models to predict grape yield and wine quality

    Directory of Open Access Journals (Sweden)

    E. A. C. Costantini

    2009-09-01

    Full Text Available The adoption of precision agriculture in viticulture could be greatly enhanced by the diffusion of straightforward and easy to be applied hydropedological models, able to predict the spatial variability of available soil water. The Lin's and Host hydropedological models were applied to standard soil series descriptions and hillslope position, to predict the distribution of hydrological functional units in two vineyard and their relevance for grape yield and wine quality. A three-years trial was carried out in Chianti (Central Italy on Sangiovese. The soils of the vineyards differentiated in structure, porosity and related hydropedological characteristics, as well as in salinity. Soil spatial variability was deeply affected by earth movement carried out before vine plantation. Six plots were selected in the different hydrological functional units of the two vineyards, that is, at summit, backslope and footslope morphological positions, to monitor soil hydrology, grape production and wine quality. Plot selection was based upon a cluster analysis of local slope, topographic wetness index (TWI, and cumulative moisture up to the root limiting layer, appreciated by means of a detailed combined geophysical survey. Water content, redox processes and temperature were monitored, as well as yield, phenological phases, and chemical analysis of grapes. The isotopic ratio δ13C was measured in the wine ethanol upon harvesting to evaluate the degree of stress suffered by vines. The grapes in each plot were collected for wine making in small barrels. The wines obtained were analysed and submitted to a blind organoleptic testing.

    The results demonstrated that the combined application of the two hydropedological models can be used for the prevision of the moisture status of soils cultivated with grape during summertime in Mediterranean climate. As correctly foreseen by the models, the amount of mean daily transpirable soil water (TSW during

  10. The fabulous fours! annual report from the editor

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2015-01-01

    Full Text Available No abstract available. Article truncated after 150 words. With the end of 2014, the Southwest Journal of Pulmonary and Critical Care (SWJPCC completed its fourth year of operation. Our first manuscript was posted on November 11, 2010. We posted 8 manuscripts our first year, 68 in 2011, 113 in 2012 and 164 in 2013 and 167 in 2014 (Table 1. Accompanying our increase in manuscripts, our readership continues to steadily grow, although comparisons to previous years is difficult because the methodology changed in February, 2014 (Table 2. SWJPCC continue to evolve and we made some changes in 2014: The California Thoracic Society partnered with SWJPCC; We added additional associate editors in pulmonary, critical care and imaging from Fresno (Peterson, Albuquerque (Boivin and Tucson (Arteaga. Many need to be thanked. First, thanks to our authors. Second, SWJPCC, like all journals, relies upon expert reviewers in order to publish the highest quality manuscripts. We thank the reviewers for their time ...

  11. The roles of the AAS Journals' Data Editors

    Science.gov (United States)

    Muench, August; NASA/SAO ADS, CERN/Zenodo.org, Harvard/CfA Wolbach Library

    2018-01-01

    I will summarize the community services provided by the AAS Journals' Data Editors to support authors’ when citing and preserving the software and data used in the published literature. In addition I will describe the life of a piece of code as it passes through the current workflows for software citation in astronomy. Using this “lifecycle” I will detail the ongoing work funded by a grant from the Alfred P. Sloan Foundation to the American Astronomical Society to improve the citation of software in the literature. The funded development team and advisory boards, made up of non-profit publishers, literature indexers, and preservation archives, is implementing the Force11 Software citation principles for astronomy Journals. The outcome of this work will be new workflows for authors and developers that fit in their current practices while enabling versioned citation of software and granular credit for its creators.

  12. Advanced software development workstation project: Engineering scripting language. Graphical editor

    Science.gov (United States)

    1992-01-01

    Software development is widely considered to be a bottleneck in the development of complex systems, both in terms of development and in terms of maintenance of deployed systems. Cost of software development and maintenance can also be very high. One approach to reducing costs and relieving this bottleneck is increasing the reuse of software designs and software components. A method for achieving such reuse is a software parts composition system. Such a system consists of a language for modeling software parts and their interfaces, a catalog of existing parts, an editor for combining parts, and a code generator that takes a specification and generates code for that application in the target language. The Advanced Software Development Workstation is intended to be an expert system shell designed to provide the capabilities of a software part composition system.

  13. Educating science editors: is there a comprehensive strategy?

    Science.gov (United States)

    Gasparyan, Armen Yuri; Yessirkepov, Marlen; Gorin, Sergey V; Kitas, George D

    2014-12-01

    The article considers available options to educate science editors in the fast-transforming digital environment. There is no single course or resource that can cover their constantly changing and diversifying educational needs. The involvement in research, writing, and reviewing is important for gaining editing skills, but that is not all. Membership in editorial associations and access to updated scholarly information in the field are mandatory for maintaining editorial credentials. Learned associations offer access to a few widely-recognized periodicals. There are also formal training courses covering issues in science writing and ethical editing, but no high-level evidence data exist to promote any of these. Networking with like-minded specialists within the global and regional editorial associations seems a useful strategy to upgrade editorial skills and resolve problems with the quality control and digitization of scholarly periodicals.

  14. Andreae is New Editor of Global Biogeochemical Cycles

    Science.gov (United States)

    Andreae, Meinrat O.

    2004-10-01

    As the incoming editor of Global Biogeochemical Cycles, I would like to introduce myself and my ideas for the journal to Eos readers and to current and potential GBC authors. I've had a somewhat ``roaming'' scientific evolution, coming from ``straight'' chemistry through hard-rock geochemistry to chemical oceanography, the field in which I did my Ph.D. I taught marine chemistry at Florida State University for a number of years, and developed an interest in ocean/atmosphere interactions and atmospheric chemistry. In 1987 I took on my present job at the Max Planck Institute for Chemistry, in Mainz, Germany, and, after leaving the seacoast, my interests shifted to interactions between the terrestrial biosphere and atmosphere, including the role of vegetation fires. My present focus is on the role of biogenic aerosols and biomass smoke in regulating cloud properties and influencing climate.

  15. EDITORIAL: A word from the new Editor-in-Chief A word from the new Editor-in-Chief

    Science.gov (United States)

    Mostowski, Jan

    2011-01-01

    TIn the autumn of 2010 I became the Editor-in Chief of European Journal of Physics (EJP). EJP is a place for teachers, instructors and professors to exchange their views on teaching physics at university level and share their experience. It is general opinion that no good research is possible without connection with good, high-quality teaching, at the university level in particular. Therefore excellence in physics teaching is important to the physics community. European Journal of Physics is proud of its contribution to achieving this goal. As Editor-in-Chief, I will continue to work to this general objective of the journal. We will publish articles on specific topics in physics, stressing originality of presentation and suitability for use in students'laboratories, lectures and physics teaching in general. We will also publish more pedagogical papers presenting the achievements of particular teaching methods. In addition, we will continue to publish special sections on particular areas of physics, as well as the annual special section on physics competitions. European Journal of Physics is in good shape. Due to the work of the previous editors and the publisher, the readership is high and growing steadily, and many excellent papers are being submitted and published. I hope that this positive trend for the journal will continue, and I will do my best to keep to this high standard. A few words about myself. I work in the Institute of Physics in Warsaw, Poland. My main research interests are in theoretical quantum optics and I have published about 80 research papers on this topic. For many years I was involved in teaching physics at university and in high school. I am a co-author of a textbook on physics for high-school students and of a problem book in quantum mechanics. For the last ten years, I have been involved in the International Physics Olympiad and over the last few years I have been a member of the Editorial Board of European Journal of Physics.

  16. Optical and electrical properties of zinc oxide thin films with low resistivity via Li-N dual-acceptor doping

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Daoli, E-mail: zhang_daoli@mail.hust.edu.cn [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Zhang Jianbing [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Guo Zhe [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Miao Xiangshui [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China)

    2011-05-19

    Highlights: > Zinc oxide films have been deposited on glass substrates by Li-N dual-acceptor doping method via a modified SILAR method. > The resistivity of ZnO film was found to be 1.04 {Omega} cm with a Hall mobility of 0.749 cm{sup 2} V{sup -1} s{sup -1}, carrier concentration of 8.02 x 1018 cm{sup -3}, and transmittance of about 80% in visible range showing good crystallinity with prior c-axis orientation. > A shallow acceptor level of 91 meV is identified from free-to-neutral-acceptor transitions. > Another deep level of 255 meV was ascribed to Li{sub Zn}-Li{sub i} complex. - Abstract: Zinc oxide thin films with low resistivity have been deposited on glass substrates by Li-N dual-acceptor doping method via a modified successive ionic layer adsorption and reaction process. The thin films were systematically characterized via scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction, ultraviolet-visible spectrophotometry and fluorescence spectrophotometry. The resistivity of zinc oxide film was found to be 1.04 {Omega} cm with a Hall mobility of 0.749 cm{sup 2} V{sup -1} s{sup -1} and carrier concentration of 8.02 x 10{sup 18} cm{sup -3}. The Li-N dual-acceptor doped zinc oxide films showed good crystallinity with prior c-axis orientation, and high transmittance of about 80% in visible range. Moreover, the effects of Li doping level and other parameters on crystallinity, electrical and ultraviolet emission of zinc oxide films were investigated.

  17. Beacon Editor: Capturing Signal Transduction Pathways Using the Systems Biology Graphical Notation Activity Flow Language.

    Science.gov (United States)

    Elmarakeby, Haitham; Arefiyan, Mostafa; Myers, Elijah; Li, Song; Grene, Ruth; Heath, Lenwood S

    2017-12-01

    The Beacon Editor is a cross-platform desktop application for the creation and modification of signal transduction pathways using the Systems Biology Graphical Notation Activity Flow (SBGN-AF) language. Prompted by biologists' requests for enhancements, the Beacon Editor includes numerous powerful features for the benefit of creation and presentation.

  18. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Combination announcer, news editor and chief engineer. 793... OF CERTAIN RADIO AND TELEVISION STATION EMPLOYEES FROM OVERTIME PAY REQUIREMENTS UNDER SECTION 13(b... editor and chief engineer. The 13(b)(9) exemption, as was made clear during the debate on the amendment...

  19. "Clones," Codes, and Conflicts of Interest in Cartooning: Cartoonists and Editors Look at Ethics.

    Science.gov (United States)

    Riffe, Daniel; And Others

    A study examined differences between political cartoonists and op-ed page editors on both traditional ethical issues (such as conflicts of interest) and the special, style-related concerns of editorial cartoonists. Hypotheses proposed were that editors and cartoonists (1) would condemn "cloning" or copying, reflecting an ethical…

  20. Authors and editors assort on gender and geography in high-rank ecological publications.

    Directory of Open Access Journals (Sweden)

    Kezia R Manlove

    Full Text Available Peer-reviewed publication volume and caliber are widely-recognized proxies for academic merit, and a strong publication record is essential for academic success and advancement. However, recent work suggests that publication productivity for particular author groups may also be determined in part by implicit biases lurking in the publication pipeline. Here, we explore patterns of gender, geography, and institutional rank among authors, editorial board members, and handling editors in high-impact ecological publications during 2015 and 2016. A higher proportion of lead authors had female first names (33.9% than editorial board members (28.9%, and the proportion of female first names among handling editors was even lower (21.1%. Female editors disproportionately edited publications with female lead authors (40.3% of publications with female lead authors were handled by female editors, though female editors handled only 34.4% of all studied publications. Additionally, ecological authors and editors were overwhelmingly from countries in the G8, and high-ranking academic institutions accounted for a large portion of both the published work, and its editorship. Editors and lead authors with female names were typically affiliated with higher-ranking institutions than their male peers. This description of author and editor features provides a baseline for benchmarking future trends in the ecological publishing culture.

  1. Transparent Model Transformation: Turning Your Favourite Model Editor into a Transformation Tool

    DEFF Research Database (Denmark)

    Acretoaie, Vlad; Störrle, Harald; Strüber, Daniel

    2015-01-01

    Current model transformation languages are supported by dedicated editors, often closely coupled to a single execution engine. We introduce Transparent Model Transformation, a paradigm enabling modelers to specify transformations using a familiar tool: their model editor. We also present VMTL, th...... model transformation tool sharing the model editor’s benefits, transparently....

  2. R. E. (Ted) Munn — Founding editor; a mini-biography

    Science.gov (United States)

    Taylor, Peter; Thomas, Morley; Truhlar, Ed; Whelpdale, Doug

    1996-02-01

    Ted Munn founded Boundary-Layer Meteorology in 1970 and served as Editor for 75 volumes over a 25 year period. This short article briefly reviews Ted's scientific career with the Atmospheric Environment Service (of Canada), the International Institute for Applied Systems Analysis in Austria and with the Institute of Environmental Studies at the University of Toronto, and as editor of this journal.

  3. Adolescent Sexual Initiation through the Lens of Letters to the Editor Published in Polish Teenage Magazines

    Science.gov (United States)

    Kopacz, Marek S.; Bajka-Kopacz, Aleksandra

    2012-01-01

    Almost all teenage magazines invite readers to submit questions concerning relationships, published as letters to the editor, popularly called "advice columns," often containing explicit questions about sexuality. This study aims to examine, firstly, how themes related to sexual initiation are presented in letters to the editor published…

  4. Authors and editors assort on gender and geography in high-rank ecological publications.

    Science.gov (United States)

    Manlove, Kezia R; Belou, Rebecca M

    2018-01-01

    Peer-reviewed publication volume and caliber are widely-recognized proxies for academic merit, and a strong publication record is essential for academic success and advancement. However, recent work suggests that publication productivity for particular author groups may also be determined in part by implicit biases lurking in the publication pipeline. Here, we explore patterns of gender, geography, and institutional rank among authors, editorial board members, and handling editors in high-impact ecological publications during 2015 and 2016. A higher proportion of lead authors had female first names (33.9%) than editorial board members (28.9%), and the proportion of female first names among handling editors was even lower (21.1%). Female editors disproportionately edited publications with female lead authors (40.3% of publications with female lead authors were handled by female editors, though female editors handled only 34.4% of all studied publications). Additionally, ecological authors and editors were overwhelmingly from countries in the G8, and high-ranking academic institutions accounted for a large portion of both the published work, and its editorship. Editors and lead authors with female names were typically affiliated with higher-ranking institutions than their male peers. This description of author and editor features provides a baseline for benchmarking future trends in the ecological publishing culture.

  5. Letter to the Editor: Re: A Five-year Survey of Cesarean Delivery at a ...

    African Journals Online (AJOL)

    Letter to the Editor: Re: A Five-year Survey of Cesarean Delivery at a Nigerian Tertiary Hospital. VO Ajuzieogu, AO Amucheazi. Abstract. Letter to the editor - no abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading .

  6. THE NEW ONLINE METADATA EDITOR FOR GENERATING STRUCTURED METADATA

    Energy Technology Data Exchange (ETDEWEB)

    Devarakonda, Ranjeet [ORNL; Shrestha, Biva [ORNL; Palanisamy, Giri [ORNL; Hook, Leslie A [ORNL; Killeffer, Terri S [ORNL; Boden, Thomas A [ORNL; Cook, Robert B [ORNL; Zolly, Lisa [United States Geological Service (USGS); Hutchison, Viv [United States Geological Service (USGS); Frame, Mike [United States Geological Service (USGS); Cialella, Alice [Brookhaven National Laboratory (BNL); Lazer, Kathy [Brookhaven National Laboratory (BNL)

    2014-01-01

    Nobody is better suited to describe data than the scientist who created it. This description about a data is called Metadata. In general terms, Metadata represents the who, what, when, where, why and how of the dataset [1]. eXtensible Markup Language (XML) is the preferred output format for metadata, as it makes it portable and, more importantly, suitable for system discoverability. The newly developed ORNL Metadata Editor (OME) is a Web-based tool that allows users to create and maintain XML files containing key information, or metadata, about the research. Metadata include information about the specific projects, parameters, time periods, and locations associated with the data. Such information helps put the research findings in context. In addition, the metadata produced using OME will allow other researchers to find these data via Metadata clearinghouses like Mercury [2][4]. OME is part of ORNL s Mercury software fleet [2][3]. It was jointly developed to support projects funded by the United States Geological Survey (USGS), U.S. Department of Energy (DOE), National Aeronautics and Space Administration (NASA) and National Oceanic and Atmospheric Administration (NOAA). OME s architecture provides a customizable interface to support project-specific requirements. Using this new architecture, the ORNL team developed OME instances for USGS s Core Science Analytics, Synthesis, and Libraries (CSAS&L), DOE s Next Generation Ecosystem Experiments (NGEE) and Atmospheric Radiation Measurement (ARM) Program, and the international Surface Ocean Carbon Dioxide ATlas (SOCAT). Researchers simply use the ORNL Metadata Editor to enter relevant metadata into a Web-based form. From the information on the form, the Metadata Editor can create an XML file on the server that the editor is installed or to the user s personal computer. Researchers can also use the ORNL Metadata Editor to modify existing XML metadata files. As an example, an NGEE Arctic scientist use OME to register

  7. Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, S.; Tanaka, J.; Okada, S.; Isobe, T.; Yamamoto, G.; Yasuhara, R.; Irie, T.; Akiyama, C.; Kohno, Y.; Tachikawa, T.; Mishima, K., E-mail: mishima-k@dent.showa-u.ac.jp

    2013-05-01

    Cancer stem cells (CSCs) are among the target cells of cancer therapy because they are uniquely involved in both cancer progression and sensitivity to chemotherapeutic agents. We identified side population (SP) cells, which are known to be an enriched population of CSC, in five oral squamous cell carcinoma (OSCC) cells (SCC9, SCC25, TOSCC7, TOSCC17, and TOSCC23). The percentages of SP cells ranged from 0% to 3.3%, with TOSCC23 cells showing the highest percentages of SP cells (3.3% of the total cell population). The SP cells isolated from TOSCC23 cells also showed greater cell proliferation and invasion compared to non-SP (MP) cells. Therefore, our initial findings suggested that SP cells were enriched for CSC-like cells. Furthermore, DNA microarray analysis revealed that the expression of cell proliferation-related and anti-apoptotic genes was greater in SP cells compared to MP cells. We focused on Lin28a, which showed the highest expression (approximately 22-fold) among the upregulated genes. The overexpression of Lin28a in TOSCC23 cells increased their proliferation, colony formation, and invasion. These findings suggest that Lin28a is an appropriate CSC target molecule for OSCC treatment - Highlights: ► Lin28a is a SP cell-specific factor in oral squamous cell carcinoma (OSCC) cells. ► SP cells in OSCC cells show cancer stem cell-like properties. ► Lin28a regulates OSCC proliferative and invasive activities.

  8. Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma

    International Nuclear Information System (INIS)

    Hayashi, S.; Tanaka, J.; Okada, S.; Isobe, T.; Yamamoto, G.; Yasuhara, R.; Irie, T.; Akiyama, C.; Kohno, Y.; Tachikawa, T.; Mishima, K.

    2013-01-01

    Cancer stem cells (CSCs) are among the target cells of cancer therapy because they are uniquely involved in both cancer progression and sensitivity to chemotherapeutic agents. We identified side population (SP) cells, which are known to be an enriched population of CSC, in five oral squamous cell carcinoma (OSCC) cells (SCC9, SCC25, TOSCC7, TOSCC17, and TOSCC23). The percentages of SP cells ranged from 0% to 3.3%, with TOSCC23 cells showing the highest percentages of SP cells (3.3% of the total cell population). The SP cells isolated from TOSCC23 cells also showed greater cell proliferation and invasion compared to non-SP (MP) cells. Therefore, our initial findings suggested that SP cells were enriched for CSC-like cells. Furthermore, DNA microarray analysis revealed that the expression of cell proliferation-related and anti-apoptotic genes was greater in SP cells compared to MP cells. We focused on Lin28a, which showed the highest expression (approximately 22-fold) among the upregulated genes. The overexpression of Lin28a in TOSCC23 cells increased their proliferation, colony formation, and invasion. These findings suggest that Lin28a is an appropriate CSC target molecule for OSCC treatment - Highlights: ► Lin28a is a SP cell-specific factor in oral squamous cell carcinoma (OSCC) cells. ► SP cells in OSCC cells show cancer stem cell-like properties. ► Lin28a regulates OSCC proliferative and invasive activities

  9. Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth

    Directory of Open Access Journals (Sweden)

    Arthur Luhur

    2017-12-01

    Full Text Available Summary: Although the intrinsic mechanisms that control whether stem cells divide symmetrically or asymmetrically underlie tissue growth and homeostasis, they remain poorly defined. We report that the RNA-binding protein fragile X mental retardation protein (FMRP limits the symmetric division, and resulting expansion, of the stem cell population during adaptive intestinal growth in Drosophila. The elevated insulin sensitivity that FMRP-deficient progenitor cells display contributes to their accelerated expansion, which is suppressed by the depletion of insulin-signaling components. This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28, known to boost insulin signaling in stem cells. Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR. This study identifies the stem cell-based mechanism by which FMRP controls tissue adaptation, and it raises the possibility that defective adaptive growth underlies the accelerated growth, gastrointestinal, and other symptoms that affect fragile X syndrome patients. : Luhur et al. report that FMRP acts via LIN-28 in progenitor cells to dampen the adaptive expansion of intestinal tissue in the fruit fly, raising the possibility that defective LIN28-mediated adaptive growth underlies some of the symptoms that affect fragile X syndrome patients. Keywords: FMRP, fmr1, LIN-28, insulin receptor, IIS, adaptive growth, tissue resizing, intestinal stem cell, insulin sensitivity

  10. Comparability of estimating energy rebound effect should be based on uniform mechanism and benchmark: A reply to Du and Lin

    International Nuclear Information System (INIS)

    Li, Chengyu; Shao, Shuai; Yang, Lili; Yu, Mingliang

    2016-01-01

    Du and Lin (2015) argued that the estimation model of the economy-wide energy rebound effect proposed by Shao et al. (2014) should be revised and provided an alternative approach, which they considered to be more consistent with the definition of the rebound effect. However, in this comment, we do not find a valid correction or modification to our original model, because their criticism logic does not originate from the corresponding mechanism in Shao et al. (2014), and their estimation formula has a different benchmark with ours. Moreover, their data samples were also different from ours, generating the incomparable results, and there are some irrational results in the comment. Even based on different estimation formulas in the two studies and using the same estimation method and data sample, the comparison results show that the problem of the estimation formula in our previous study which they claimed does not really exist. We argue that this comment is not consistent with the principle of the rebound effect. Actually, their work can be only regarded as proposing an alternative approach for the estimate of the rebound effect. Therefore, their argument is not enough to overturn our previous study. - Highlights: • A reply to Du and Lin (2015), who questioned our previous study, is provided. • Their criticism logic does not originate from our corresponding mechanism. • Their estimation formula has a different benchmark with ours. • Different data samples in the two papers make their results incomparable. • Their argument is not enough to overturn our previous study.

  11. Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B.

    Science.gov (United States)

    Lee, Chih-Yung Sean; Lu, Tu; Seydoux, Geraldine

    2017-11-07

    Nanos RNA-binding proteins are required for germline development in metazoans, but the underlying mechanisms remain poorly understood. We have profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs nos-1 and nos-2 in C. elegans. nos-1nos-2 PGCs fail to silence hundreds of transcripts normally expressed in oocytes. We find that this misregulation is due to both delayed turnover of maternal transcripts and inappropriate transcriptional activation. The latter appears to be an indirect consequence of delayed turnover of the maternally-inherited transcription factor LIN-15B, a synMuvB class transcription factor known to antagonize PRC2 activity. PRC2 is required for chromatin reprogramming in the germline, and the transcriptome of PGCs lacking PRC2 resembles that of nos-1nos-2 PGCs. Loss of maternal LIN-15B restores fertility to nos-1nos-2 mutants. These findings suggest that Nanos promotes germ cell fate by downregulating maternal RNAs and proteins that would otherwise interfere with PRC2-dependent reprogramming of PGC chromatin.

  12. Weak activity of haloalkane dehalogenase LinB with 1,2,3-trichloropropane revealed by X-Ray crystallography and microcalorimetry.

    Science.gov (United States)

    Monincová, Marta; Prokop, Zbynek; Vévodová, Jitka; Nagata, Yuji; Damborsky, Jirí

    2007-03-01

    1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (k(cat) = 0.005 s(-1)) of LinB with TCP using X-ray crystallography and microcalorimetry. This observation makes LinB a useful starting material for the development of a new biocatalyst toward TCP by protein engineering. Microcalorimetry is proposed to be a universal method for the detection of weak enzymatic activities. Detection of these activities is becoming increasingly important for engineering novel biocatalysts using the scaffolds of proteins with promiscuous activities.

  13. Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-Ray Crystallography and Microcalorimetry▿

    Science.gov (United States)

    Monincová, Marta; Prokop, Zbyněk; Vévodová, Jitka; Nagata, Yuji; Damborský, Jiří

    2007-01-01

    1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (kcat = 0.005 s−1) of LinB with TCP using X-ray crystallography and microcalorimetry. This observation makes LinB a useful starting material for the development of a new biocatalyst toward TCP by protein engineering. Microcalorimetry is proposed to be a universal method for the detection of weak enzymatic activities. Detection of these activities is becoming increasingly important for engineering novel biocatalysts using the scaffolds of proteins with promiscuous activities. PMID:17259360

  14. Analysis of the results of the first implementation of the Korea Manuscript Editors Certification

    Directory of Open Access Journals (Sweden)

    Hyun Jung Yi

    2017-02-01

    Full Text Available In the field of international scholarly journal publishing, manuscript editing has been established as an essential component of the publication process. As the necessity of this process has increased, the Korean Council of Science Editors has consistently provided education for training professional manuscript editors, and has worked to implement a manuscript editor certification system. Starting in 2014, the Korean Council of Science Editors thoroughly conducted background research and advanced analysis in preparation for such a system. Subsequently, a committee of experts was formed to develop and simulate an examination for this certification. This process culminated in the first manuscript editor certification examination, which was held in November 2016 and resulted in 40 initial Korea Manuscript Editors Certification holders. Examinations for the Korea Manuscript Editors Certification are scheduled to be held annually. The establishment of this certification system will contribute to strengthening individual capacities and further developing science journal publication in Korea by expanding the field of manuscript editing. Ultimately, this system will contribute to the promotion of Korean scientific journals to the level of prominent international journals.

  15. Quantifying the effect of editor-author relations on manuscript handling times.

    Science.gov (United States)

    Sarigöl, Emre; Garcia, David; Scholtes, Ingo; Schweitzer, Frank

    2017-01-01

    In this article we study to what extent the academic peer review process is influenced by social relations between the authors of a manuscript and the editor handling the manuscript. Taking the open access journal PlosOne as a case study, our analysis is based on a data set of more than 100,000 articles published between 2007 and 2015. Using available data on handling editor, submission and acceptance time of manuscripts, we study the question whether co-authorship relations between authors and the handling editor affect the manuscript handling time , i.e. the time taken between the submission and acceptance of a manuscript. Our analysis reveals (1) that editors handle papers co-authored by previous collaborators significantly more often than expected at random, and (2) that such prior co-author relations are significantly related to faster manuscript handling. Addressing the question whether these shorter manuscript handling times can be explained by the quality of publications, we study the number of citations and downloads which accepted papers eventually accumulate. Moreover, we consider the influence of additional (social) factors, such as the editor's experience, the topical similarity between authors and editors, as well as reciprocal citation relations between authors and editors. Our findings show that, even when correcting for other factors like time, experience, and performance, prior co-authorship relations have a large and significant influence on manuscript handling times, speeding up the editorial decision on average by 19 days.

  16. Editors' Introduction: New Perspectives on 'The War-Prayer'

    Directory of Open Access Journals (Sweden)

    Shelley Fisher Fishkin

    2009-02-01

    Full Text Available "The War-Prayer," written a hundred years ago as Mark Twain reflected on the conditions surrounding the U.S. decision to embark on the imperialist venture known as the Philippine-American War, speaks to us across time in strikingly uncanny ways. Although today "The War-Prayer" is increasingly accessible to readers worldwide, this important piece by Mark Twain has never received the critical attention that it warrants. Neither has it occupied the place that it deserves in the Mark Twain canon, or in the American literary canon. In the years since its first publication in 1923, it has often been reprinted. But it rarely appears in anthologies of American literature, and it is among the least well-known works by Twain as far as the general public is concerned. Indeed, educated individuals are often startled and shocked when they are introduced to this piece, dumbfounded as to why they never encountered it before. A question worth pondering: How might American history and world history in the 20th century have been different if "The War-Prayer" had been as familiar to every high school student as Tom Sawyer? As editors of this international forum on "The War-Prayer" in Mark Twain Studies, we are pleased to be able to give this important work by Mark Twain some of the attention that it has long deserved.

  17. Consed: a graphical editor for next-generation sequencing.

    Science.gov (United States)

    Gordon, David; Green, Phil

    2013-11-15

    The rapid growth of DNA sequencing throughput in recent years implies that graphical interfaces for viewing and correcting errors must now handle large numbers of reads, efficiently pinpoint regions of interest and automate as many tasks as possible. We have adapted consed to reflect this. To allow full-feature editing of large datasets while keeping memory requirements low, we developed a viewer, bamScape, that reads billion-read BAM files, identifies and displays problem areas for user review and launches the consed graphical editor on user-selected regions, allowing, in addition to longstanding consed capabilities such as assembly editing, a variety of new features including direct editing of the reference sequence, variant and error detection, display of annotation tracks and the ability to simultaneously process a group of reads. Many batch processing capabilities have been added. The consed package is free to academic, government and non-profit users, and licensed to others for a fee by the University of Washington. The current version (26.0) is available for linux, macosx and solaris systems or as C++ source code. It includes a user's manual (with exercises) and example datasets. http://www.phrap.org/consed/consed.html dgordon@uw.edu .

  18. KISS for STRAP: user extensions for a protein alignment editor.

    Science.gov (United States)

    Gille, Christoph; Lorenzen, Stephan; Michalsky, Elke; Frömmel, Cornelius

    2003-12-12

    The Structural Alignment Program STRAP is a comfortable comprehensive editor and analyzing tool for protein alignments. A wide range of functions related to protein sequences and protein structures are accessible with an intuitive graphical interface. Recent features include mapping of mutations and polymorphisms onto structures and production of high quality figures for publication. Here we address the general problem of multi-purpose program packages to keep up with the rapid development of bioinformatical methods and the demand for specific program functions. STRAP was remade implementing a novel design which aims at Keeping Interfaces in STRAP Simple (KISS). KISS renders STRAP extendable to bio-scientists as well as to bio-informaticians. Scientists with basic computer skills are capable of implementing statistical methods or embedding existing bioinformatical tools in STRAP themselves. For bio-informaticians STRAP may serve as an environment for rapid prototyping and testing of complex algorithms such as automatic alignment algorithms or phylogenetic methods. Further, STRAP can be applied as an interactive web applet to present data related to a particular protein family and as a teaching tool. JAVA-1.4 or higher. http://www.charite.de/bioinf/strap/

  19. "Observation Obscurer" - Time Series Viewer, Editor and Processor

    Science.gov (United States)

    Andronov, I. L.

    The program is described, which contains a set of subroutines suitable for East viewing and interactive filtering and processing of regularly and irregularly spaced time series. Being a 32-bit DOS application, it may be used as a default fast viewer/editor of time series in any compute shell ("commander") or in Windows. It allows to view the data in the "time" or "phase" mode, to remove ("obscure") or filter outstanding bad points; to make scale transformations and smoothing using few methods (e.g. mean with phase binning, determination of the statistically opti- mal number of phase bins; "running parabola" (Andronov, 1997, As. Ap. Suppl, 125, 207) fit and to make time series analysis using some methods, e.g. correlation, autocorrelation and histogram analysis: determination of extrema etc. Some features have been developed specially for variable star observers, e.g. the barycentric correction, the creation and fast analysis of "OC" diagrams etc. The manual for "hot keys" is presented. The computer code was compiled with a 32-bit Free Pascal (www.freepascal.org).

  20. [Heavy metal pollution characteristics and ecological risk analysis for soil in Phyllostachys praecox stands of Lin'an].

    Science.gov (United States)

    Fang, Xiao-bo; Shi, Han; Liao, Xin-feng; Lou, Zhong; Zhou, Lyu-yan; Yu, Hai-xia; Yao, Lin; Sun, Li-ping

    2015-06-01

    An investigation was carried out in an attempt to reveal the characteristics of heavy metals contamination in the soils of Phyllostachys praecox forest in Lin' an. Based on the concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in 160 topsoil samples, the pollution status and ecological risks of heavy metals in the soils were assessed by single factor pollution index, Nemerow integrated pollution index and Hankanson potential ecological risk index. The spatial variability of heavy metal concentrations in the soils closely related to the distribution of traffic, industrial and livestock pollution sources. The average concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in the soils were 0.16, 7.41, 34.36, 87.98, 103.98, 0.26, 59.12, 29.56, 11.44 and 350.26 mg · kg(-1), respectively. Pb, Cd, Zn and Cu concentrations were as 2.89, 1.70, 1.12 and 1.12 times as the background values of soil in Zhejiang Province, respectively. But their concentrations were all lower than the threshold values of the National Environmental Quality Standard for Soil (GB 15618-1995). The average single factor pollution index revealed that the level of heavy metal pollution in the soils was in order of Pb>Cd>Cu= Zn>Hg>As>Ni>Co>Cr>Mn. Pb pollution was of moderate level while Cd, Cu and Zn pollutions were slight. There was no soil pollution caused by the other heavy metals. However, the Nemerow integrated pollution index showed that all the 160 soil samples were contaminated by heavy metals to a certain extent. Among total 160 soil samples, slight pollution level, moderate pollution level and heavy pollution level accounted for 55.6%, 29.4% and 15.0%, respectively. The average single factor potential ecological risk index (Er(i)) implied that the potential ecological risk related to Cd reached moderate level, while the others were of slight level. Furthermore, Cd and Hg showed higher potential ecological risk indices which reached up to 256.82 and 187.33 respectively

  1. A MULHER NEGRA E AS RELAÇÕES DE GÊNERO EM MENINO DE ENGENHO DE JOSÉ LINS DO REGO THE BLACK WOMAN AND GENDER RELATIONS IN MENINO DE ENGENHO BY JOSÉ LINS DO REGO

    Directory of Open Access Journals (Sweden)

    Zélia Monteiro Bora ; Marina Rodrigues de Oliveira

    2011-02-01

    Full Text Available Os romances do ciclo da cana-de-açúcar, do escritor paraibano José Lins do Rego (1901-1957 e a sua relação com a sociedade e a cultura destacam-se enquanto abordagens ficcionais, através das quais o escritor buscou representar aspectos relevantes para o entendimento das relações de gênero no Nordeste, no começo do século vinte. Tal representação, indiscutivelmente, reflete a perspectiva de um narrador profundamente marcado pelo lugar privilegiado de onde narra e de sua condição existencial, como o neto de um senhor de engenho. Diante desses aspectos, propomo- nos a analisar brevemente as implicações dessa perspectiva sobre a construção simbólica da personagem negra representada no romance. Para tanto, serão utilizados como referenciais críticos, além do citado romance, os estudos de Zagury (1982, Albuquerque Jr. (1999, Azevedo (1996, 2007, Freyre (2006 Chaguri (2009, Schwarz (2008 e Raboni (2010.The so called sugar cane cycle novels by the Parahyban writer Jose Lins do Rego (1901-197 and its relationship with society and culture constitute themselves as fictional approaches through which the writer sought to represent aspects to the understanding of gender relations in the Northeast of Brazil in the early twentieth century. Such representation, undoubtedly reflects the perspective of a narrator deeply marked by the privileged place from which he narrates and his existential condition, as the son of a plantation owner. Given these aspects, we propose to examine briefly the implications of his perspective on the symbolic construction of the black woman characteres represented in the novel. The following

  2. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors´ Network.

    Science.gov (United States)

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Cas, Livio Dei; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; Filipiak, Krzysztof J; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J J; Varga, Albert; Lüscher, Thomas F

    2017-05-01

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability-, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors´ Network of the European Society of Cardiology. Resumo O Comitê Internacional de Editores de Revistas Médicas (ICMJE) fornece recomendações para aprimorar o padrão editorial e a qualidade científica das revistas biomédicas. Tais recomendações variam desde requisitos técnicos de uniformização até assuntos editoriais mais complexos e elusivos, como os aspectos éticos do processo científico. Recentemente, foram propostos registro de ensaios clínicos, divulgação de conflitos de interesse e novos critérios de autoria, enfatizando a importância da responsabilidade e da responsabilização. No último ano, lançou-se uma nova iniciativa editorial para fomentar o compartilhamento dos dados de ensaios clínicos. Esta revisão discute essa nova iniciativa visando a aumentar a conscientização de leitores, investigadores, autores e editores filiados à Rede de Editores da Sociedade Europeia de Cardiologia.

  3. Editor's welcome, PORTAL, Vol. 6, No. 1, January 2009

    Directory of Open Access Journals (Sweden)

    Paul Allatson

    2009-08-01

    Full Text Available ‘The Space Between: Languages, Translations and Cultures’ is a special issue of PORTAL Journal of Multidisciplinary International Studies guest-edited by Vera Mackie (University of Melbourne, Ikuko Nakane (University of Melbourne, and Emi Otsuji (University of Technology, Sydney. As Vera Mackie and Stephanie Hemelryk Donald (University of Sydney say in the introduction to the special issue: All of the contributors to this special issue have reflected on the stakes involved in negotiating differences in language and culture. In their research and professional practice they inhabit the ‘space between’: the space between languages, the space between cultures, and the space between academic disciplines. While many of our contributors are located in the Australian university system, we also have contributors from outside that system, as well as contributors who are theorising disparate sites for the negotiation of difference. The most exciting aspect of the papers presented here is the ability to move between the spheres of cultural theory and the everyday. Analytical techniques originally developed for literary and cultural analysis are brought to bear on the texts and practices of everyday life. In addition to the critical essays, three cultural works also intervene in the discussion over what it means to inhabit the ‘space between’ languages, cultures and countries. The guest editors and the PORTAL editorial committee would like to acknowledge and thank the following institutions and individual for the support that made this special issue possible: the Australian Research Council’s Cultural Research Network; the former Institute for International Studies at the University of Technology, Sydney; the School of Historical Studies at the University of Melbourne; and the ARC Cultural Literacies Node Convener, Mark Gibson.

  4. Avogadro: an advanced semantic chemical editor, visualization, and analysis platform.

    Science.gov (United States)

    Hanwell, Marcus D; Curtis, Donald E; Lonie, David C; Vandermeersch, Tim; Zurek, Eva; Hutchison, Geoffrey R

    2012-08-13

    The Avogadro project has developed an advanced molecule editor and visualizer designed for cross-platform use in computational chemistry, molecular modeling, bioinformatics, materials science, and related areas. It offers flexible, high quality rendering, and a powerful plugin architecture. Typical uses include building molecular structures, formatting input files, and analyzing output of a wide variety of computational chemistry packages. By using the CML file format as its native document type, Avogadro seeks to enhance the semantic accessibility of chemical data types. The work presented here details the Avogadro library, which is a framework providing a code library and application programming interface (API) with three-dimensional visualization capabilities; and has direct applications to research and education in the fields of chemistry, physics, materials science, and biology. The Avogadro application provides a rich graphical interface using dynamically loaded plugins through the library itself. The application and library can each be extended by implementing a plugin module in C++ or Python to explore different visualization techniques, build/manipulate molecular structures, and interact with other programs. We describe some example extensions, one which uses a genetic algorithm to find stable crystal structures, and one which interfaces with the PackMol program to create packed, solvated structures for molecular dynamics simulations. The 1.0 release series of Avogadro is the main focus of the results discussed here. Avogadro offers a semantic chemical builder and platform for visualization and analysis. For users, it offers an easy-to-use builder, integrated support for downloading from common databases such as PubChem and the Protein Data Bank, extracting chemical data from a wide variety of formats, including computational chemistry output, and native, semantic support for the CML file format. For developers, it can be easily extended via a powerful

  5. Editor's welcome, PORTAL, Vol. 2, No. 1, January 2005

    Directory of Open Access Journals (Sweden)

    Paul Allatson

    2005-03-01

    Full Text Available This special issue of PORTAL Journal of Multidisciplinary International Studies, jointly edited by Jo McCormack and Paul Allatson, is dedicated to exile and social transformation. Some of the papers presented here derive from a highly successful workshop and symposium on exile held at the Institute for International Studies, University of Technology Sydney, in July and December 2004. Others arrived in response to a call for papers sent out in early 2004, which attracted a great deal of attention. We would like to thank all those involved at the first two events for their productive discussions and feedback, and extend our thanks to the many people who responded to the call for papers on the topic. The next issue of PORTAL will also be a special issue, “Strange Localities: Utopias, Intellectuals and National Identities in the 21st Century,” with three guest editors: Alistair Fox (University of Otago, Murray Pratt (University of Technology, Sydney, and Hilary Radner (University of Otago. And, as always, we would like to encourage practitioners of international studies and cultural producers working anywhere in the world, and in any of the PORTAL languages, to submit material for future issues. Finally, and returning to this issue’s special theme, it was with great sadness that we learned from one of the contributors to this issue, Sue Hajdú, of her father’s recent death. Sue’s critical and creative meditation on her father’s status as a Hungarian exile is one of this issue’s highlights. On behalf of the members of the Portal Editorial Committee, this special issue is dedicated to him. Paul Allatson, Chair, PORTAL Editorial Committee

  6. Editor's welcome, PORTAL, Vol. 3, No. 1, January 2006

    Directory of Open Access Journals (Sweden)

    Paul Allatson

    2006-02-01

    Full Text Available Welcome to the first appearance of PORTAL for 2006 (vol. 3, no. 1, a special issue entitled ‘Other Worlds’ guest edited by James Goodman and Christina Ho from the Faculty of Humanities and Social Sciences, University of Technology Sydney (UTS. The papers collected in this special issue focus on what the guest editors call “the transformative power of social movements” that respond to the processes and discourses of globalization and globalism by generating alternative sites and spaces of agency, or ‘other worlds.’ The contributors to the issue originally presented papers at a conference held in April 2005 in Sydney, with the title ‘Other Worlds: Social Movements and the Making of Alternatives.’ That conference was organized by the Research Initiative on International Activism at UTS, and supported by the Research Committee on Social Movements and Collective Action of the International Sociological Association. The Editorial Committee of PORTAL would like to thank both institutions for their support of the event that led to this special issue. I would also like to thank Wayne Peake, Kate Barclay, and Murray Pratt for their editorial efforts in seeing this issue through to publication. The Editorial Committee is pleased to showcase in the Cultural Works Section a short meditative piece by local writer Joel Scott, who is currently undertaking studies in Pamplona, Spain. When considered in the context of the special issue’s discussions of ‘other worlds’ that precede it, Scott’s ‘God, We’re Not Immigrants! A Reflection on Moving and Staying,’ provides an evocative insight into the sociocultural and imaginative limits that may preclude the construction of alternative ‘worlds.’

  7. Scientific style and format: the CSE manual for authors, editors, and publishers

    National Research Council Canada - National Science Library

    Council of Science Editors. Style Manual Committee

    2006-01-01

    Scientific style and format : the CSE manual for authors, editors, and publishers is a detailed and authoritative manual recommending both general and scientific publication style and format for scientific papers, journal...

  8. A model-driven development approach for learning design using the LPCEL Editor

    Directory of Open Access Journals (Sweden)

    Jorge Torres

    2014-01-01

    Full Text Available Complex learning scenarios are represented using Educational Modeling Languages (EMLs. Different people with specific skills usually design these scenarios. The IMS LD is a commonly used EML for which some visual editors are being created in order to assist the authoring process. However, these editors have a limited level of expressiveness and do not provide the facilities for designers to collaborate in the design process. The LPCEL Editor provides a broad level of expressiveness and facilitates the authoring process with an editor that includes: (1 Visual Elements, (2 Intermediate Representation, (3 Learning Patterns, (4 Collaboration tools and (5 Web Services. In order to verify that the components are sufficient, we conducted a user evaluation to analyze their perspective regarding the level of functionality of the tools.

  9. Adequacy of authors' replies to criticism raised in electronic letters to the editor: cohort study

    DEFF Research Database (Denmark)

    Gøtzsche, Peter C; Delamothe, Tony; Godlee, Fiona

    2010-01-01

    To investigate whether substantive criticism in electronic letters to the editor, defined as a problem that could invalidate the research or reduce its reliability, is adequately addressed by the authors....

  10. Special issues as criterion for journal quality evaluation: Letter to editor

    Directory of Open Access Journals (Sweden)

    Dadkhah Mehdi

    2015-01-01

    Full Text Available Predatory publishers are defined as publishers who have financial goals. This definition was introduced for the first time by Jeffrey Beall (2012. In some predatory publishers, we can find some papers that are not related to journal's aim and scope. These journals create special issues in order to publish papers that are not related to journal's aim and scope. Thus, we are faced with a question of how the editor of these journals could evaluate these papers. In some trusted journals, editor invites guest editors for special issues, which are related to journal's aim and scope. On the other hand predatory publishers, publish papers without any external reviewers or guest editors. In addition, some journals that publish irrelevant papers in regular issues are also found. This problem can be seen especially in some biological or life science journals. It seems that these problems pose new challenge for the academic world.

  11. Search for the signature of a halo structure in the p(6He,6Li)n reaction

    International Nuclear Information System (INIS)

    Cortina-Gil, M.D.; Roussel-Chomaz, P.; Mittig, W.; Casandjian, J.M.; Chartier, M.; Alamanos, N.; Auger, F.; Fekou-Youmbi, V.; Blumenfeld, Y.; and others.

    1995-01-01

    The elastic scattering p( 6 He, 6 He)p and charge exchange reaction p( 6 He, 6 Li)n have been measured in reverse kinematics with a secondary 6 He beam. The angular distributions for these reactions were obtained. In the case of the charge exchange reaction, the ratio of the cross section for the Gamow-Teller transition to the ground state, and for the Fermi transition to the isobaric analog state is a measure of the relative strength of the two components of the exchange interaction. This ratio is found compatible with existing systematics for stable T=1 nuclei, and no clear signature of a halo structure was found in the present data. (author)

  12. Regio- and Enantioselective Sequential Dehalogenation of rac-1,3-Dibromobutane by Haloalkane Dehalogenase LinB.

    Science.gov (United States)

    Gross, Johannes; Prokop, Zbyněk; Janssen, Dick; Faber, Kurt; Hall, Mélanie

    2016-08-03

    The hydrolytic dehalogenation of rac-1,3-dibromobutane catalyzed by the haloalkane dehalogenase LinB from Sphingobium japonicum UT26 proceeds in a sequential fashion: initial formation of intermediate haloalcohols followed by a second hydrolytic step to produce the final diol. Detailed investigation of the course of the reaction revealed favored nucleophilic displacement of the sec-halogen in the first hydrolytic event with pronounced R enantioselectivity. The second hydrolysis step proceeded with a regioselectivity switch at the primary position, with preference for the S enantiomer. Because of complex competition between all eight possible reactions, intermediate haloalcohols formed with moderate to good ee ((S)-4-bromobutan-2-ol: up to 87 %). Similarly, (S)-butane-1,3-diol was formed at a maximum ee of 35 % before full hydrolysis furnished the racemic diol product. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Digital cultural heritage and its applications: case studies of Digital Mogao Grottos and Chi Lin Nunnery reconstruction

    Science.gov (United States)

    Li, Deren; Du, Zhiqiang; Zhu, Yixuan; Wang, Tingsong

    2010-11-01

    Considerable damage has been done to the cultural heritage sites around the world ranging from natural erosion to artificial destruction. With the development of information sciences, frontier technologies are actively introduced to help protect cultural heritage sites. The new concept of a Digital Cultural Heritage has been presented for culture protection and is gradually becoming an efficient method to solve or to remit various difficult problems. This paper puts forward a digitalization method for cultural heritage sites which rationally integrates and utilizes multiform surveying measurements. These techniques have been successfully implemented into two projects, namely the Digital Mogao Grottos and the Chi Lin Nunnery reconstruction. Our results prove that the concept of and the techniques utilized in Digital Cultural Heritage can not only contribute to research, preservation, management, interpretation, and representation of cultural heritages but can also help resolve the conflicts between tourism and protection.

  14. Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, B. Y. [Key Laboratory of Excited State Process, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033 (China); School of Physics and Optoelectronic Technology, Dalian University of Technology, Dalian 116023 (China); Yao, B. [Key Laboratory of Excited State Process, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033 (China); State Key Laboratory of Superhard Material, Department of Physics, Jilin University, Changchun 130023 (China); Li, Y. F.; Xing, G. Z. [State Key Laboratory of Superhard Material, Department of Physics, Jilin University, Changchun 130023 (China); Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore); Liu, A. M. [School of Physics and Optoelectronic Technology, Dalian University of Technology, Dalian 116023 (China); Zhang, Z. Z.; Li, B. H.; Zhao, D. X.; Shan, C. X.; Shen, D. Z. [Key Laboratory of Excited State Process, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033 (China); Wu, T. [Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore); Qin, X. B. [Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2011-10-31

    Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to V{sub Zn}, such as V{sub Zn} and Li{sub i}-N{sub O}-V{sub Zn} complex, well supported by first-principles calculations. The incorporation of N{sub O} can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Li{sub i} to form Li{sub i}-N{sub O} complex, which restrains the compensation of Li{sub i} for V{sub Zn} and makes the ZnO:(Li, N) conduct in p-type.

  15. Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

    International Nuclear Information System (INIS)

    Zhang, B. Y.; Yao, B.; Li, Y. F.; Xing, G. Z.; Liu, A. M.; Zhang, Z. Z.; Li, B. H.; Zhao, D. X.; Shan, C. X.; Shen, D. Z.; Wu, T.; Qin, X. B.

    2011-01-01

    Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to V Zn , such as V Zn and Li i -N O -V Zn complex, well supported by first-principles calculations. The incorporation of N O can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Li i to form Li i -N O complex, which restrains the compensation of Li i for V Zn and makes the ZnO:(Li, N) conduct in p-type.

  16. Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

    Science.gov (United States)

    Zhang, B. Y.; Yao, B.; Li, Y. F.; Liu, A. M.; Zhang, Z. Z.; Li, B. H.; Xing, G. Z.; Wu, T.; Qin, X. B.; Zhao, D. X.; Shan, C. X.; Shen, D. Z.

    2011-10-01

    Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to VZn, such as VZn and Lii-NO-VZn complex, well supported by first-principles calculations. The incorporation of NO can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Lii to form Lii-NO complex, which restrains the compensation of Lii for VZn and makes the ZnO:(Li, N) conduct in p-type.

  17. An Extension of the Lin-Kernighan-Helsgaun TSP Solver for Constrained Traveling Salesman and Vehicle Routing Problems

    DEFF Research Database (Denmark)

    Helsgaun, Keld

    This report describes the implementation of an extension of the Lin-Kernighan-Helsgaun TSP solver for solving constrained traveling salesman and vehicle routing problems. The extension, which is called LKH-3, is able to solve a variety of well-known problems, including the sequential ordering...... problem (SOP), the traveling repairman problem (TRP), variants of the multiple travel-ing salesman problem (mTSP), as well as vehicle routing problems (VRPs) with capacity, time windows, pickup-and-delivery and distance constraints. The implementation of LKH-3 builds on the idea of transforming...... the problems into standard symmetric traveling salesman problems and handling constraints by means of penalty functions. Extensive testing on benchmark instances from the literature has shown that LKH-3 is effective. Best known solutions are often obtained, and in some cases, new best solutions are found...

  18. ''SMILE'': A Self Magnetically Insulated Transmission LinE adder for the 8-stage RADLAC II accelerator

    International Nuclear Information System (INIS)

    Mazarakis, M.G.; Poukey, J.W.; Shope, S.L.; Frost, C.A.; Turman, B.N.; Ramirez, J.J.; Prestwich, K.R.; Pankuch, P.J.

    1991-01-01

    The RADLAC II Self Magnetically Insulated Transmission LinE ''SMILE'' is a coaxial wave guide structure that is composed of two regions: (a) a 9.5-m voltage adder and (b) a 3-m long extension section. The adder section provides for the addition of the input voltages from the individual water-dielectric pulse forming line feeds. The extension section isolates the adder from the magnetically immersed foilless diode electron source load and efficiently transports the pulsed power out from the deionized water tank of the device. The SMILE modification of the RADLAC II accelerator enabled us to produce high quality beams of up to 14 MV, 100 kA. The design and the experimental evaluation of SMILE will be presented and compared with numerical simulation predictions. 12 refs., 9 figs., 1 tab

  19. Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.

    Science.gov (United States)

    Wu, Tian-Fu; Li, Yi-Cun; Ma, Si-Rui; Bing-Liu; Zhang, Wen-Feng; Sun, Zhi-Jun

    2017-04-01

    Tumor necrosis factor receptor-associated factor 1, an adaptor protein of tumor necrosis factor 2, is involved in classical nuclear factor (NF)-κB activation and lymphocyte recruitment. However, less is known about the expression and association of tumor necrosis factor receptor-associated factor 1 with cancer stem cell markers in oral squamous cell carcinoma. This study aimed to investigate the expression of tumor necrosis factor receptor-associated factor 1 and stem cell characteristic markers (lin28 homolog B, B cell-specific Moloney murine leukemia virus integration site 1, and aldehyde dehydrogenase 1) in oral squamous cell carcinoma and analyze their relations. Paraffin-embedded tissues of 78 oral squamous cell carcinomas, 39 normal oral mucosa, and 12 oral dysplasia tissues were employed in tissue microarrays, and the expression of tumor necrosis factor receptor-associated factor 1, B cell-specific Moloney murine leukemia virus integration site 1, aldehyde dehydrogenase 1, and lin28 homolog B was measured by immunohistostaining and digital pathological analysis. The expression of tumor necrosis factor receptor-associated factor 1 was higher in the oral squamous cell carcinoma group as compared with the expression in the oral mucosa (p oral dysplasia (p oral squamous cell carcinoma. The patient survival rate was lower in the highly expressed tumor necrosis factor receptor-associated factor 1 group, although the difference was not significant. The clustering analysis showed that tumor necrosis factor receptor-associated factor 1 was most related to aldehyde dehydrogenase 1. These findings suggest that tumor necrosis factor receptor-associated factor 1 has potential direct/indirect regulations with the cancer stem cell markers in oral squamous cell carcinoma, which may help in further analysis of the cancer stem cell characteristics.

  20. Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study

    Science.gov (United States)

    Bell, Chaim M; Matelski, John J; Detsky, Allan S; Cram, Peter

    2017-01-01

    Objective To estimate financial payments from industry to US journal editors. Design Retrospective observational study. Setting 52 influential (high impact factor for their specialty) US medical journals from 26 specialties and US Open Payments database, 2014. Participants 713 editors at the associate level and above identified from each journal’s online masthead. Main outcome measures All general payments (eg, personal income) and research related payments from pharmaceutical and medical device manufacturers to eligible physicians in 2014. Percentages of editors receiving payments and the magnitude of such payments were compared across journals and by specialty. Journal websites were also reviewed to determine if conflict of interest policies for editors were readily accessible. Results Of 713 eligible editors, 361 (50.6%) received some (>$0) general payments in 2014, and 139 (19.5%) received research payments. The median general payment was $11 (£8; €9) (interquartile range $0-2923) and the median research payment was $0 ($0-0). The mean general payment was $28 136 (SD $415 045), and the mean research payment was $37 963 (SD $175 239). The highest median general payments were received by journal editors from endocrinology ($7207, $0-85 816), cardiology ($2664, $0-12 912), gastroenterology ($696, $0-20 002), rheumatology ($515, $0-14 280), and urology ($480, $90-669). For high impact general medicine journals, median payments were $0 ($0-14). A review of the 52 journal websites revealed that editor conflict of interest policies were readily accessible (ie, within five minutes) for 17/52 (32.7%) of journals. Conclusions Industry payments to journal editors are common and often large, particularly for certain subspecialties. Journals should consider the potential impact of such payments on public trust in published research. PMID:29074628

  1. Artificial intelligence in peer review: How can evolutionary computation support journal editors?

    OpenAIRE

    Mrowinski, Maciej J.; Fronczak, Piotr; Fronczak, Agata; Ausloos, Marcel; Nedic, Olgica

    2017-01-01

    With the volume of manuscripts submitted for publication growing every year, the deficiencies of peer review (e.g. long review times) are becoming more apparent. Editorial strategies, sets of guidelines designed to speed up the process and reduce editors' workloads, are treated as trade secrets by publishing houses and are not shared publicly. To improve the effectiveness of their strategies, editors in small publishing groups are faced with undertaking an iterative trial-and-error approach. ...

  2. An Interview with Masoud Yazdani, editor of London-based Intellect Books

    Directory of Open Access Journals (Sweden)

    Sean Scanlan

    2014-03-01

    Full Text Available Sean Scanlan conducted an email interview with Masoud Yazdani, the editor of Intellect Books, an independent academic publisher in the fields of creative practice and popular culture, whose aim is to publish scholarly books and journals that provide a vital space for widening critical debate in new and emerging subjects. An Interview with Masoud Yazdani, editor of London-based Intellect Books by Sean Scanlan.

  3. Report of the world association of medical editors: agenda for the future.

    Science.gov (United States)

    2001-04-01

    During a 3-day meeting at Bellagio in January 2001, a group of 20 editors from 12 countries in 5 continents met to map out a strategy for the World Association of Medical Editors (WAME)'s continued development in the service of medical editors over the next several years. The group: 1) Developed a statement of principles on the standards of professionalism and responsibilities of editors (this statement will be posted on the Web site after electronic consultation with and comment by WAME editors); 2) Agreed to assess the extent to which these principles are reflected in practice and to explore barriers to their adoption, using data from a survey and focus groups; 3) Developed and outlined an on-line program for distance learning, targeted at new editors; 4) Planned for formal evaluation of the educational outreach program; and 5) Agreed to support regional initiatives to strengthen local editorial capacity. Underpinning all past and proposed future activities is the WAME Web site. The ambitious plans outlined above will require extensive development of the site, plans for which were made at the Bellagio meeting.

  4. Applying a Multiple Screening Program Aided by a Guideline-driven Computerized Decision Support System—A Pilot Experience in Yun-Lin, Taiwan

    Directory of Open Access Journals (Sweden)

    Jou-Wei Lin

    2007-01-01

    Conclusion: A computer-aided screening program driven by the US Preventive Services Task Force recommendations has been successfully implemented in Yun-Lin, Taiwan, and provided useful information about local epidemiology and implications for future health policy making. [J Formos Med Assoc 2007; 106(1:58-68

  5. Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549.

    Science.gov (United States)

    Liu, Wei-Lun; Chang, Jia-Ming; Chong, Inn-Wen; Hung, Yi-Li; Chen, Yung-Hsiang; Huang, Wen-Tsung; Kuo, Hsuan-Fu; Hsieh, Chong-Chao; Liu, Po-Len

    2017-06-03

    Metastasis is common in lung cancer and is associated with poor clinical outcomes and increased mortality. Curcumin is a natural anti-cancer agent that inhibits the metastasis of various cancers by modulating the expression of micro (mi) RNAs such as miR-98, which acts as a tumor suppressor. This study investigated the effect of curcumin on miR-98 expression and in vitro cell line growth and invasiveness in lung cancer. Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase ( MMP ) 2 and MMP9 in vitro and in vivo. MiR-98 overexpression suppressed lung cancer cell migration and invasion by inhibiting LIN28A-induced MMP2 and MMP9 expression. Meanwhile, LIN28A level was downregulated by overexpression of miR-98 mimic. Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A. These findings provide insight into the mechanisms by which curcumin suppresses lung cancer cell line growth in vitro and in vivo and invasiveness in vitro.

  6. The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development.

    Science.gov (United States)

    Lee, Sang In; Jeon, Mi-Hyang; Kim, Jeom Sun; Jeon, Ik-Soo; Byun, Sung June

    2015-12-01

    Early chick embryogenesis is governed by a complex mechanism involving transcriptional and post-transcriptional regulation, although how post-transcriptional processes influence the balance between pluripotency and differentiation during early chick development have not been previously investigated. Here, we characterized the microRNA (miRNA) signature associated with differentiation in the chick embryo, and found that as expression of the gga-let-7 family increases through early development, expression of their direct targets, TGFBR1 and LIN28B, decreases; indeed, gga-let-7a-5p and gga-let-7b miRNAs directly bind to TGFBR1 and LIN28B transcripts. Our data further indicate that TGFBR1 and LIN28B maintain pluripotency by regulating POUV, NANOG, and CRIPTO. Therefore, gga-let-7 miRNAs act as post-transcriptional regulators of differentiation in blastodermal cells by repressing the expression of the TGFBR1 and LIN28B, which intrinsically controls blastodermal cell differentiation in early chick development. © 2015 Wiley Periodicals, Inc.

  7. The Many Sides of Happy Lim: aka Hom Ah Wing, Lin Jian Fu, Happy Lum, Lin Chien Fu, Hom Yen Chuck, Lam Kin Foo, Lum Kin Foo, Hom, Lim Goon Wing, Lim Gin Foo, Gin Foo Lin, Koon Wing Lim, Henry Chin, Lim Ying Chuck, Lim Ah Wing, et. al.

    Directory of Open Access Journals (Sweden)

    Gordon H. Chang

    2010-03-01

    Full Text Available

    Known to the FBI, INS, and IRS as Mr. Ah Wing Hom, he was also Lin Jian Fu, Jian Fu (Tough Guy, or just Fu to the readers of the many poems and short stories he published in Chinese over four decades in the twentieth century. And to still others, primarily English-readers of his writing, he was Happy Lim, an ironic, even tragically bizarre name, as his life was far from pleasant. On New Year's Day 1986, he died alone in a dingy San Francisco Chinatown bachelor hotel suffering from a bacterial infection and a chronic blood disorder that had required the amputation of all his toes the year before. He was seventy-eight years of age and had spent most of his life within blocks of where he died.

  8. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    Science.gov (United States)

    Gardner, Jason S.

    2012-01-01

    As I begin my tenure as Editor-in-Chief of Journal of Physics: Condensed Matter (JPCM), I look upon this opportunity as both an honour and a real challenge. The journal is in great shape thanks to the work of my predecessors, Marshall Stoneham and David Ferry. The journal's solid reputation is based largely on the work these gentlemen have done over the past decade. The other main reason for the success of JPCM is the amazing staff in Bristol; keep up the good work, please. When discussing the journal with scientists from all corners of the globe, one thing is always mentioned—JPCM is a very reliable journal with well-written, high-quality papers, and a fast but rigorous peer-review process that provides fair, detailed and constructive referee reports for the benefit of authors. This is due almost entirely to our great authors and referees; we rely on them every day—thank you. As the new Editor-in-Chief I hope to continue to improve still further the journal's status in condensed matter science. As mentioned above, our reputation is excellent, but the reality is that we live in a world of bibliometrics and rankings. Over the past few years JPCM has been repositioned as a journal at the forefront of condensed matter physics, and the impact of the journal should increase further as a result of continued emphasis on commissioning in cutting-edge areas identified by the Editorial Board and the journal team. In addition to regular papers, JPCM has a number of other content streams that authors and readers can benefit from. Fast track communications (FTCs) offer exceptionally fast publication for work of the highest impact and urgency. By their select nature, FTCs benefit from personal treatment by the Editorial Board and the average receipt-to-first-decision time is just 11 days (the average receipt-to-publication time is just 45 days). Topical reviews in JPCM make the journal one of the most authoritative sources of review content for condensed matter physics

  9. Editor's welcome, PORTAL, Vol. 1, No. 2, July 2004

    Directory of Open Access Journals (Sweden)

    Paul Allatson

    2005-03-01

    Full Text Available Since the highly successful inauguration of PORTAL in January 2004, we have received many kind expressions of support from international studies practitioners in a range of fields, and from such places as Canada, Italy, Mexico, Nigeria, New Zealand, Spain, Trinidad, the U.K., and the U.S.A. Particularly gratifying have been the endorsements of the journal and its publishing aims by people involved in their own electronic publishing enterprises. For their generous responses to PORTAL, the Editorial Committee would like to express its collective appreciation to the following people: Professor Jean-Marie Volet, of the University of Western Australia, and the guiding editor of the ground-breaking e-journal Mots Pluriels (www.arts.uwa.edu.au/MotsPluriels; and Francis Leo Collins, member of the Editorial Committee for the Graduate Journal of Asia Pacific Studies (GJAPS, based in Auckland, New Zealand. PORTAL's readers may be interested in the current call for papers from GJAPS (www.arts.auckland.ac.nz/gjaps, for a special issue on "Imagining the Asia-Pacific" (deadline October 31, 2004. This issue of PORTAL contains essays that cover wide terrain: the Chilean diasporic community in Australia; the world of German intellectuals; contemporary Mexican socio-political movements; rural-urban migration in China; and transnational advocacy networks and election monitoring in the Philippines, Chile, Nicaragua and Mexico. In the cultural section of this issue, we are delighted to present a short story from the noted German Studies scholar Anthony Stephens, and the first half of a beautiful, deeply poetic and haunting novel entitled Son, from the London-based writer and art-critic Jennifer Higgie. The novel’s second and final part will appear in PORTAL vol. 2, no. 1, in January 2005. On a different note, we would like to express our support for the inaugural Ubud Writers and Readers Festival, to be held in Ubud, Bali, from October 11 to 17, 2004. The Festival

  10. Editors' welcome, PORTAL, Vol 7, No 2, July 2010

    Directory of Open Access Journals (Sweden)

    Paul Allatson

    2010-11-01

    , Editor, PORTAL Journal of Multidisciplinary International Studies.

  11. Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

    Directory of Open Access Journals (Sweden)

    Hanwell Marcus D

    2012-08-01

    Full Text Available Abstract Background The Avogadro project has developed an advanced molecule editor and visualizer designed for cross-platform use in computational chemistry, molecular modeling, bioinformatics, materials science, and related areas. It offers flexible, high quality rendering, and a powerful plugin architecture. Typical uses include building molecular structures, formatting input files, and analyzing output of a wide variety of computational chemistry packages. By using the CML file format as its native document type, Avogadro seeks to enhance the semantic accessibility of chemical data types. Results The work presented here details the Avogadro library, which is a framework providing a code library and application programming interface (API with three-dimensional visualization capabilities; and has direct applications to research and education in the fields of chemistry, physics, materials science, and biology. The Avogadro application provides a rich graphical interface using dynamically loaded plugins through the library itself. The application and library can each be extended by implementing a plugin module in C++ or Python to explore different visualization techniques, build/manipulate molecular structures, and interact with other programs. We describe some example extensions, one which uses a genetic algorithm to find stable crystal structures, and one which interfaces with the PackMol program to create packed, solvated structures for molecular dynamics simulations. The 1.0 release series of Avogadro is the main focus of the results discussed here. Conclusions Avogadro offers a semantic chemical builder and platform for visualization and analysis. For users, it offers an easy-to-use builder, integrated support for downloading from common databases such as PubChem and the Protein Data Bank, extracting chemical data from a wide variety of formats, including computational chemistry output, and native, semantic support for the CML file format

  12. Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer.

    Science.gov (United States)

    Lu, Lingeng; Katsaros, Dionyssios; Mayne, Susan T; Risch, Harvey A; Benedetto, Chiara; Canuto, Emilie Marion; Yu, Herbert

    2012-11-01

    Several single-nucleotide polymorphisms (SNPs) of the stem cell-associated gene lin-28B have been identified in association with ovarian cancer and ovarian cancer-related risk factors. However, whether these SNPs are functional or might be potential biomarkers for ovarian cancer prognosis remains unknown. The purposes of this study were to investigate the functional relevance of the identified lin-28B SNPs, as well as the associations of genotype and phenotype with epithelial ovarian cancer (EOC) survival. We analyzed five SNPs and mRNA levels of lin-28B in 211 primary EOC tissues using Taqman(®) SNP genotyping assays and SYBR green-based real-time PCR, respectively. The RNA secondary structures at the region of a genome-wide association-identified intronic rs314276 were analyzed theoretically with mfold and experimentally with circular dichroism spectroscopy. We found that rs314276 was a cis-acting expression quantitative trait locus (eQTL) in both additive and dominant models, while rs7759938 and rs314277 were significant or of borderline significance in dominant models only. The rs314276 variant significantly affects RNA secondary structure. No SNPs alone were associated with patient survival. However, we found that among patients initially responding to chemotherapy, those with higher lin-28B expression had higher mortality risk (hazard ratio =3.27, 95% confidence interval: 1.63-6.56) and relapse risk (hazard ratio = 2.53, 95% confidence interval: 1.41-4.54) than those with lower expression, and these associations remained in multivariate analyses. These results suggest that rs314276 alters RNA secondary structure and thereby influences gene expression, and that lin-28B is a cancer stem cell-associated marker, which may be a pharmaceutical target in the management of EOC.

  13. A scoping review of competencies for scientific editors of biomedical journals.

    Science.gov (United States)

    Galipeau, James; Barbour, Virginia; Baskin, Patricia; Bell-Syer, Sally; Cobey, Kelly; Cumpston, Miranda; Deeks, Jon; Garner, Paul; MacLehose, Harriet; Shamseer, Larissa; Straus, Sharon; Tugwell, Peter; Wager, Elizabeth; Winker, Margaret; Moher, David

    2016-02-02

    Biomedical journals are the main route for disseminating the results of health-related research. Despite this, their editors operate largely without formal training or certification. To our knowledge, no body of literature systematically identifying core competencies for scientific editors of biomedical journals exists. Therefore, we aimed to conduct a scoping review to determine what is known on the competency requirements for scientific editors of biomedical journals. We searched the MEDLINE®, Cochrane Library, Embase®, CINAHL, PsycINFO, and ERIC databases (from inception to November 2014) and conducted a grey literature search for research and non-research articles with competency-related statements (i.e. competencies, knowledge, skills, behaviors, and tasks) pertaining to the role of scientific editors of peer-reviewed health-related journals. We also conducted an environmental scan, searched the results of a previous environmental scan, and searched the websites of existing networks, major biomedical journal publishers, and organizations that offer resources for editors. A total of 225 full-text publications were included, 25 of which were research articles. We extracted a total of 1,566 statements possibly related to core competencies for scientific editors of biomedical journals from these publications. We then collated overlapping or duplicate statements which produced a list of 203 unique statements. Finally, we grouped these statements into seven emergent themes: (1) dealing with authors, (2) dealing with peer reviewers, (3) journal publishing, (4) journal promotion, (5) editing, (6) ethics and integrity, and (7) qualities and characteristics of editors. To our knowledge, this scoping review is the first attempt to systematically identify possible competencies of editors. Limitations are that (1) we may not have captured all aspects of a biomedical editor's work in our searches, (2) removing redundant and overlapping items may have led to the

  14. CINCO VOZES NUM COTIDIANO DE SOMBRAS: “PENTÁGONO DE HAHN”, DE OSMAN LINS

    Directory of Open Access Journals (Sweden)

    Cícero Émerson do Nascimento Cardoso (URCA

    2013-11-01

    Full Text Available Este trabalho se pauta na análise da obra “Pentágono de Hahn”, que integra a obra “Nove, novena – narrativas”, de Osman Lins. A partir da chegada de um circo a uma cidade interiorana que apresenta, dentre seus espetáculos, a elefanta “Hahn”, cinco personagens expõem suas existências fadadas à brutalidade de um cotidiano “repleto” de vazios e experiências não vividas. O autor, nessa obra, arquiteta uma enredística polifônica que excede em lirismo, acuidade psicológica e catalogação de valores humanos indevassáveis o que a torna um profícuo objeto de estudo aberto às mais amplas incursões em se tratando de produção literária moderna.

    Palavras-chave: Modernismo; Narrativa moderna; Osman Lins.

  1. Conceptual design of a generic pulse schedule and event handling editor for improved fusion device operation

    Energy Technology Data Exchange (ETDEWEB)

    Barana, Oliviero, E-mail: oliviero.barana@cea.fr [CEA, IRFM, F-13108 Saint-Paul-Lez Durance (France); Nouailletas, Rémy; Brémond, Sylvain; Moreau, Philippe; Allegretti, Ludovic; Balme, Stéphane; Ravenel, Nathalie [CEA, IRFM, F-13108 Saint-Paul-Lez Durance (France); Mannori, Simone [ENEA C.R. Brasimone, 40032 Camugnano (Italy); Guillerminet, Bernard; Leroux, Fabrice; Douai, David; Nardon, Eric; Hertout, Patrick; Saint-Laurent, François [CEA, IRFM, F-13108 Saint-Paul-Lez Durance (France)

    2013-10-15

    Highlights: ► Real-time event handling requires extended functionalities of pulse schedule editors and plasma control systems ► A new pulse schedule editor, conceived for parameterization of systematic off-normal event handling, is described ► A global, generic approach on off-normal event handling is highlighted ► The functional architecture of an off-normal event handling oriented plasma control system is discussed ► The main objects of the pulse schedule editor are the segment-descriptor object and the scenario-descriptor object. -- Abstract: Coping with unexpected events is an important issue of nuclear fusion experiments. The future machines, characterized by very long plasma discharges and actively cooled metallic plasma-facing components, will require a systematic intervention in real time, in order to maximize the performance and protect the investment. The real-time management of events will require extending the functionalities of the current pulse schedule editors with the possibility of using reference waveforms provided with acceptability margins and setting up advanced mitigation strategies and event countermeasures. With this purpose, a new pulse schedule editor, based on a time-segment approach for the preparation of experimental scenarios, is being conceived on Tore Supra, together with a new plasma control system. This paper will report on their conceptual design and give account of the preliminary results of a feasibility study currently under way in order to prepare a possible implementation on Tore Supra.

  2. Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes.

    Directory of Open Access Journals (Sweden)

    Paul D Goetsch

    2017-11-01

    Full Text Available The DREAM (Dp/Retinoblastoma(Rb-like/E2F/MuvB transcriptional repressor complex acts as a gatekeeper of the mammalian cell cycle by establishing and maintaining cellular quiescence. How DREAM's three functional components, the E2F-DP heterodimer, the Rb-like pocket protein, and the MuvB subcomplex, form and function at target gene promoters remains unknown. The current model invokes that the pocket protein links E2F-DP and MuvB and is essential for gene repression. We tested this model by assessing how the conserved yet less redundant DREAM system in Caenorhabditis elegans is affected by absence of the sole C. elegans pocket protein LIN-35. Using a LIN-35 protein null mutant, we analyzed the assembly of E2F-DP and MuvB at promoters that are bound by DREAM and the level of expression of those "DREAM target genes" in embryos. We report that LIN-35 indeed mediates the association of E2F-DP and MuvB, a function that stabilizes DREAM subunit occupancy at target genes. In the absence of LIN-35, the occupancy of E2F-DP and MuvB at most DREAM target genes decreases dramatically and many of those genes become upregulated. The retention of E2F-DP and MuvB at some target gene promoters in lin-35 null embryos allowed us to test their contribution to DREAM target gene repression. Depletion of MuvB, but not E2F-DP, in the sensitized lin-35 null background caused further upregulation of DREAM target genes. We conclude that the pocket protein functions primarily to support MuvB-mediated repression of DREAM targets and that transcriptional repression is the innate function of the evolutionarily conserved MuvB complex. Our findings provide important insights into how mammalian DREAM assembly and disassembly may regulate gene expression and the cell cycle.

  3. Crystal structures of MW1337R and lin2004: Representatives of a novel protein family that adopt a four-helical bundle fold

    Energy Technology Data Exchange (ETDEWEB)

    Kozbial, Piotr; Xu, Qingping; Chiu, Hsiu-Ju; McMullan, Daniel; Krishna, S. Sri; Miller, Mitchell D.; Abdubek, Polat; Acosta, Claire; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Clayton, Thomas; Deller, Marc; Duan, Lian; Elias, Ylva; Elsliger, Marc-André; Feuerhelm, Julie; Grzechnik, Slawomir K.; Hale, Joanna; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kumar, Abhinav; Marciano, David; Morse, Andrew T.; Murphy, Kevin D.; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Reyes, Ron; Rife, Christopher L.; Spraggon, Glen; Trout, Christina V.; ban den Bedem, Henry; Weekes, Dana; White, Aprilfawn; Wolf, Guenter; Zubieta, Chloe; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. (Scripps); (SSRL); (JCSG); (UCSD); (Burnham)

    2009-08-28

    To extend the structural coverage of proteins with unknown functions, we targeted a novel protein family (Pfam accession number PF08807, DUF1798) for which we proposed and determined the structures of two representative members. The MW1337R gene of Staphylococcus aureus subsp. aureus Rosenbach (Wood 46) encodes a protein with a molecular weight of 13.8 kDa (residues 1-116) and a calculated isoelectric point of 5.15. The lin2004 gene of the nonspore-forming bacterium Listeria innocua Clip11262 encodes a protein with a molecular weight of 14.6 kDa (residues 1-121) and a calculated isoelectric point of 5.45. MW1337R and lin2004, as well as their homologs, which, so far, have been found only in Bacillus, Staphylococcus, Listeria, and related genera (Geobacillus, Exiguobacterium, and Oceanobacillus), have unknown functions and are annotated as hypothetical proteins. The genomic contexts of MW1337R and lin2004 are similar and conserved in related species. In prokaryotic genomes, most often, functionally interacting proteins are coded by genes, which are colocated in conserved operons. Proteins from the same operon as MW1337R and lin2004 either have unknown functions (i.e., belong to DUF1273, Pfam accession number PF06908) or are similar to ypsB from Bacillus subtilis. The function of ypsB is unclear, although it has a strong similarity to the N-terminal region of DivIVA, which was characterized as a bifunctional protein with distinct roles during vegetative growth and sporulation. In addition, members of the DUF1273 family display distant sequence similarity with the DprA/Smf protein, which acts downstream of the DNA uptake machinery, possibly in conjunction with RecA. The RecA activities in Bacillus subtilis are modulated by RecU Holliday-junction resolvase. In all analyzed cases, the gene coding for RecU is in the vicinity of MW1337R, lin2004, or their orthologs, but on a different operon located in the complementary DNA strand. Here, we report the crystal structures

  4. Safety and Feasibility of Lin- Cells Administration to ALS Patients: A Novel View on Humoral Factors and miRNA Profiles

    Directory of Open Access Journals (Sweden)

    Anna Sobuś

    2018-04-01

    Full Text Available Therapeutic options for amyotrophic lateral sclerosis (ALS are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF, brain-derived neurotrophic factor (BDNF, and vascular endothelial growth factor (VEGF and in the immune modulating features, in particular, the anti-inflammatory effects. In our study we aimed to investigate whether a bone marrow-derived lineage-negative (Lin- cells population, after autologous application into cerebrospinal fluid (CSF, is able to produce noticeable concentrations of trophic factors and inflammatory-related proteins and thus influence the clinical course of ALS. To our knowledge, the evaluation of Lin- cells transplantation for ALS treatment has not been previously reported. Early hematopoietic Lin- cells were isolated from twelve ALS patients’ bone marrow, and later, the suspension of cells was administered into the subarachnoid space by lumbar puncture. Concentrations of selected proteins in the CSF and plasma were quantified by multiplex fluorescent bead-based immunoassays at different timepoints post-transplantation. We also chose microRNAs (miRNAs related to muscle biology (miRNA-1, miRNA-133a, and miRNA-206 and angiogenesis and inflammation (miRNA-155 and miRNA-378 and tested, for the first time, their expression profiles in the CSF and plasma of ALS patients after Lin- cells transplantation. The injection of bone marrow cells resulted in decreased concentration of selected inflammatory proteins (C3 after Lin- cells injection, particularly in patients who had a better clinical outcome. Moreover, several analyzed miRNAs have changed expression levels in the CSF and plasma of ALS patients subsequent to Lin- cells administration. Interestingly, the expression of miR-206 increased in ALS patients, while miR-378 decreased both in the CSF and plasma one month after the cells’ injection. We propose that autologous lineage

  5. Safety and Feasibility of Lin- Cells Administration to ALS Patients: A Novel View on Humoral Factors and miRNA Profiles.

    Science.gov (United States)

    Sobuś, Anna; Baumert, Bartłomiej; Litwińska, Zofia; Gołąb-Janowska, Monika; Stępniewski, Jacek; Kotowski, Maciej; Pius-Sadowska, Ewa; Kawa, Miłosz P; Gródecka-Szwajkiewicz, Dorota; Peregud-Pogorzelski, Jarosław; Dulak, Józef; Nowacki, Przemysław; Machaliński, Bogusław

    2018-04-27

    Therapeutic options for amyotrophic lateral sclerosis (ALS) are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF)) and in the immune modulating features, in particular, the anti-inflammatory effects. In our study we aimed to investigate whether a bone marrow-derived lineage-negative (Lin-) cells population, after autologous application into cerebrospinal fluid (CSF), is able to produce noticeable concentrations of trophic factors and inflammatory-related proteins and thus influence the clinical course of ALS. To our knowledge, the evaluation of Lin- cells transplantation for ALS treatment has not been previously reported. Early hematopoietic Lin- cells were isolated from twelve ALS patients’ bone marrow, and later, the suspension of cells was administered into the subarachnoid space by lumbar puncture. Concentrations of selected proteins in the CSF and plasma were quantified by multiplex fluorescent bead-based immunoassays at different timepoints post-transplantation. We also chose microRNAs (miRNAs) related to muscle biology (miRNA-1, miRNA-133a, and miRNA-206) and angiogenesis and inflammation (miRNA-155 and miRNA-378) and tested, for the first time, their expression profiles in the CSF and plasma of ALS patients after Lin- cells transplantation. The injection of bone marrow cells resulted in decreased concentration of selected inflammatory proteins (C3) after Lin- cells injection, particularly in patients who had a better clinical outcome. Moreover, several analyzed miRNAs have changed expression levels in the CSF and plasma of ALS patients subsequent to Lin- cells administration. Interestingly, the expression of miR-206 increased in ALS patients, while miR-378 decreased both in the CSF and plasma one month after the cells’ injection. We propose that autologous lineage-negative early

  6. Andrij Makuch and Frank E. Sysyn, editors. Contextualizing the Holodomor: The Impact of Thirty Years of Ukrainian Famine Studies

    Directory of Open Access Journals (Sweden)

    Johnathon Vsetecka

    2017-03-01

    Full Text Available Book review of Andrij Makuch and Frank E. Sysyn, editors. Contextualizing the Holodomor: The Impact of Thirty Years of Ukrainian Famine Studies. Canadian Institute of Ukrainian Studies P, 2015. viii, 128 pp. $24.95, paper. Conference papers first published in East/West: Journal of Ukrainian Studies, editor-in-chief, Oleh S. Ilnytzkyj, guest editors, Frank Sysyn and Andrij Makuch, vol. 2, no. 1, 2015, pp. 3-132.

  7. Adequacy of authors' replies to criticism raised in electronic letters to the editor

    DEFF Research Database (Denmark)

    Gøtzsche, Peter C; Delamothe, Tony; Godlee, Fiona

    2010-01-01

    . Inclusion criteria Research papers generating substantive criticism in the rapid responses section on bmj.com. MAIN OUTCOME MEASURES: Severity of criticism (minor, moderate, or major) as judged by two editors and extent to which the criticism was addressed by authors (fully, partly, or not) as judged by two......OBJECTIVE: To investigate whether substantive criticism in electronic letters to the editor, defined as a problem that could invalidate the research or reduce its reliability, is adequately addressed by the authors. DESIGN: Cohort study. SETTING: BMJ between October 2005 and September 2007...... editors and the critics. RESULTS: A substantive criticism was raised against 105 of 350 (30%, 95% confidence interval 25% to 35%) included research papers, and of these the authors had responded to 47 (45%, 35% to 54%). The severity of the criticism was the same in those papers as in the 58 without author...

  8. Role of editors and journals in detecting and preventing scientific misconduct: strengths, weaknesses, opportunities, and threats.

    Science.gov (United States)

    Marusic, Ana; Katavic, Vedran; Marusic, Matko

    2007-09-01

    Scientific journals have a central place in protecting research integrity because published articles are the most visible documentation of research. We used SWOT analysis to audit (S)trengths and (W)eaknesses as internal and (O)pportunities and (T)hreats as external factors affecting journals' responsibility in addressing research integrity issues. Strengths include editorial independence, authority and expertise, power to formulate editorial policies, and responsibility for the integrity of published records. Weaknesses stem from having no mandate for legal action, reluctance to get involved, and lack of training. Opportunities for editors are new technologies for detecting misconduct, policies by editorial organization or national institutions, and greater transparency of published research. Editors face threats from the lack of legal regulation and culture of research integrity in academic communities, lack of support from stakeholders in scientific publishing, and different pressures. Journal editors cannot be the policing force of the scientific community but they should actively ensure the integrity of the scientific record.

  9. Editor's welcome, PORTAL Vol. 3, No. 2, July 2006

    Directory of Open Access Journals (Sweden)

    Paul Allatson

    2006-09-01

    Full Text Available The second issue of PORTAL Journal of Multidisciplinary International Studies for 2006 features a special selection of essays grouped under the title ‘Women in Asia’ and guest-edited by Devleena Ghosh and Barbara Leigh, both from the University of Technology Sydney. The essays in this special issue had their first incarnations at the Eighth Women in Asia Conference, ‘Shadow Lines’, organised by the Women’s Caucus of the Asian Studies Association of Australia and the University of Technology Sydney (convened by Ghosh and Leigh, and held at the University of Technology Sydney from 26 to the 28 September 2005. Aiming self-consciously and tacitly to toy with, and dispute, the historical and discursive valencies accruing to the key, twined terms ‘women’ and ‘Asia’, the ten essays grouped here combine to form a rich repository of contemporary research about the status of women in many parts of that vast, arguably incoherent, geocultural space called Asia. All of the contributing authors thus ‘attempt to unsettle discourses about limits,’ to cite from co-editor Devleena Ghosh’s opening paper. That attempt is far from straightforward, as Ghosh elaborates: ‘That lines, borders and boundaries exist, whether of prejudice, politics, economics, or culture, is undeniable. But how do we analyse these issues without ossifying them, creating implacable alterities that refuse the liminal spaces that people occupy?’ Multivalent solutions are called for, Ghosh suggests, and these are to be found not simply in ‘counter-politics and interventions’, but also through the excavation and recognition of multiple subjectivities from/in ‘a thousand plateaus, [and] felt and experienced through the body, historical landscapes, domestic spaces, through performance as well as through the realm of the imaginary, in the impact of ideals and the weight of history’. In addition to the special section on ‘Women in Asia’, this edition of PORTAL

  10. Synthèse et validation d'une loi de commande linéaire robuste de braquage d'une automobile

    OpenAIRE

    MENHOUR, Lghani; LECHNER, Daniel; CHARARA, Ali

    2010-01-01

    Ce papier propose la synthèse d'un retour d'état robuste préprogrammé pour le contrôle de direction d'un véhicule. Celui-ci est utilisé pour simuler le comportement du véhicule sous des fortes sollicitations dynamiques. Les contraintes d'inégalités matricielles linéaires (LMI) et un modèle linéaire à paramètres variants sont utilisés pour la synthèse du retour d'état. Ensuite, une méthode d'interpolation des gains est utilisée pour la conception d'un retour d'état robuste préprogrammé. La str...

  11. Tip 2 Diabetes Mellituslu Hastalarda Mikroalbuminüri, İnsülin Direnci ve Kardiyovasküler Risk

    OpenAIRE

    ERSOY, Canan; TAŞLI, Babürşah; YILDIZ, Abdülmecit; İMAMOĞLU, Şazi

    2006-01-01

    Son çalışmalar tip 2 diyabette mikroalbuminüri (MAU) varlığı ile hedef organ hasarları ve kardiyovasküler hastalık riski arasındaki ilişkilere yönelmişlerdir. Bu çalışmada, Tip 2 diabetes mellituslu (DM) hastalarda MAU ile glisemik kontrol, insülin direnci (İR) ve diğer kardiyovasküler risk faktörleri arasındaki ilişki değerlendirilmiştir. İnsülin gereksinimi olmayan, normal renal fonksiyonlu 29 mikroalbuminürik ve 68 normoalbuminürik tip 2 DM'lu hasta çalışmaya dahil edildi. Tüm hast...

  12. Magazine or journal--what is the difference? The role of the monitoring editor.

    Science.gov (United States)

    Bretscher, Anthony

    2013-04-01

    Scientific communication, career advancement, and funding decisions are all dependent on research publications. The way manuscripts are handled by high-visibility, professionally edited magazines differs from the way academic journals evaluate manuscripts, using active scientists as monitoring editors. In this essay, I discuss the benefits that come with the involvement of active scientists. I enumerate the decisions a monitoring editor has to make, and how he or she goes about making them. Finally, I indicate ways in which authors can help to make the process a smoother and more positive experience.

  13. Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study.

    Science.gov (United States)

    Liu, Jessica J; Bell, Chaim M; Matelski, John J; Detsky, Allan S; Cram, Peter

    2017-10-26

    Objective  To estimate financial payments from industry to US journal editors. Design  Retrospective observational study. Setting  52 influential (high impact factor for their specialty) US medical journals from 26 specialties and US Open Payments database, 2014. Participants  713 editors at the associate level and above identified from each journal's online masthead. Main outcome measures  All general payments (eg, personal income) and research related payments from pharmaceutical and medical device manufacturers to eligible physicians in 2014. Percentages of editors receiving payments and the magnitude of such payments were compared across journals and by specialty. Journal websites were also reviewed to determine if conflict of interest policies for editors were readily accessible. Results  Of 713 eligible editors, 361 (50.6%) received some (>$0) general payments in 2014, and 139 (19.5%) received research payments. The median general payment was $11 (£8; €9) (interquartile range $0-2923) and the median research payment was $0 ($0-0). The mean general payment was $28 136 (SD $415 045), and the mean research payment was $37 963 (SD $175 239). The highest median general payments were received by journal editors from endocrinology ($7207, $0-85 816), cardiology ($2664, $0-12 912), gastroenterology ($696, $0-20 002), rheumatology ($515, $0-14 280), and urology ($480, $90-669). For high impact general medicine journals, median payments were $0 ($0-14). A review of the 52 journal websites revealed that editor conflict of interest policies were readily accessible (ie, within five minutes) for 17/52 (32.7%) of journals. Conclusions  Industry payments to journal editors are common and often large, particularly for certain subspecialties. Journals should consider the potential impact of such payments on public trust in published research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a

  14. Nota breve del editor y traductor de la «Ética nicomaquea»

    OpenAIRE

    Batalla, Josep

    2017-01-01

    Una breu exposició de les dificultats en l'edició de l'Ètica nicomaquea d'Aristòtil i una breu presentació del mode de resoldre-les escollit per l'editor. This note provides a summary explanation of the difficulties in editing the Nicomachean Ethics of Aristotle and a brief presentation of the way the editor has chosen to resolve them. Una breve exposición de las dificultades en la edición de la Ética nicomaquea de Aristóteles y una breve presentación del modo de resolverlas escogido po...

  15. Complete PCB design using OrCAD capture and PCB editor

    CERN Document Server

    Mitzner, Kraig

    2009-01-01

    This book provides instruction on how to use the OrCAD design suite to design and manufacture printed circuit boards. The primary goal is to show the reader how to design a PCB using OrCAD Capture and OrCAD Editor. Capture is used to build the schematic diagram of the circuit, and Editor is used to design the circuit board so that it can be manufactured. The book is written for both students and practicing engineers who need in-depth instruction on how to use the software, and who need background knowledge of the PCB design process. KEY FEATURES:* Beginning to end cove

  16. Survey Research in the Forest Science Journals - Insights from Journal Editors

    Directory of Open Access Journals (Sweden)

    Mirjana Stevanov

    2015-06-01

    Full Text Available Background and Purpose: Survey research is one of the most commonly applied approaches in the social sciences. In the forest research it has been used for more than five decades. In spite of that or the fact that the amount of survey-based articles in the forest science journals has increased during the last decade, their share in all articles published in 20 forest science journals (9,372 articles, 2005-2014 is quite modest (3.2%. In our paper we look at the opinions and attitudes of forest science journal editors towards survey research, as their perspective might enlarge our understanding of the use of this approach in the field of forestry. Materials and Methods: We selected 20 forest science journals - 15 from the SCI list and five non-SCI journals and contacted editors of these journals with the self-administered e-mail questionnaire. Data were collected in October 2014 and analyzed by descriptive statistics. The overall response rate was 75%. The assumptions for the study were based on the evidence addressing opinions and attitudes of journal editors from other research fields (finance since no similar study was found in the field of forestry. Results: The majority of editors reported the same review process for survey-based articles as for all others. In two journals, articles with the survey-based content are screened more rigorously and in two journals their publishing is generally discouraged. 40% of journal editors hold the view that no difference should be made between survey research and other types of original research, and another 40% think that survey research should in the first place play a complementary role. As the main strength of survey research editors see the possibility to obtain data unavailable from other sources. They perceive adverse selection and the difficulty to generalize results as the main weaknesses. Conclusions: Editors of forest science journals have similar opinion on survey research as those from the

  17. Development of a conversational text editor on MITRA 125 used with a TEKTRONIX 4014 display console

    International Nuclear Information System (INIS)

    Siffre, Evelyne.

    1980-06-01

    The purpose of this study, which falls within the purview of a nuclear physics research laboratory, is the development of a simple to use conversational text editor to mitigate the defects of the MMT2 monitor. The operations to be executed are: - creation of a source file written in FORTRAN - concatenation of the various stages to obtain a workable program: FORTRAN compilation, edition of links, group generation; - execution of this program. These operations are performed in two different ways: 1) by using the system controls as from the teleprinter (this corresponds to the previous use). The sequence of controls to be effected is described; 2) by using the EDI 125 conversational editor [fr

  18. Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

    Science.gov (United States)

    Dahlin, Joakim S; Malinovschi, Andrei; Öhrvik, Helena; Sandelin, Martin; Janson, Christer; Alving, Kjell; Hallgren, Jenny

    2016-01-28

    Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from committed bone marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothelium, and mature in the tissue. In humans, mast cells can be cultured from multipotent CD34(+) progenitor cells. However, a population of distinct precursor cells that give rise to mast cells has remained undiscovered. To our knowledge, this is the first report of human lineage-negative (Lin(-)) CD34(hi) CD117(int/hi) FcεRI(+) progenitor cells, which represented only 0.0053% of the isolated blood cells in healthy individuals. These cells expressed integrin β7 and developed a mast cell-like phenotype, although with a slow cell division capacity in vitro. Isolated Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells had an immature mast cell-like appearance and expressed high levels of many mast cell-related genes as compared with human blood basophils in whole-transcriptome microarray analyses. Furthermore, serglycin, tryptase, and carboxypeptidase A messenger RNA transcripts were detected by quantitative reverse transcription-polymerase chain reaction. Altogether, we propose that the Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood mast cell progenitors than asthmatics with normal lung function. © 2016 by The American Society of Hematology.

  19. Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-Ray Crystallography and Microcalorimetry▿

    OpenAIRE

    Monincová, Marta; Prokop, Zbyněk; Vévodová, Jitka; Nagata, Yuji; Damborský, Jiří

    2007-01-01

    1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (kcat = 0.005 s−1) of Li...

  20. Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences

    OpenAIRE

    Grandien, Kaj; Sommer, Ralf J.

    2001-01-01

    Hox transcription factors have been implicated in playing a central role in the evolution of animal morphology. Many studies indicate the evolutionary importance of regulatory changes in Hox genes, but little is known about the role of functional changes in Hox proteins. In the nematodes Pristionchus pacificus and Caenorhabditis elegans, developmental processes can be compared at the cellular, genetic, and molecular levels and differences in gene function can be identified. The Hox gene lin-3...

  1. Qualidade de um sistema latossolo-argissolo como receptor de efluentes no município de Lins(SP Quality of a latosol-argisol system in the county of Lins/SP, Brazil

    Directory of Open Access Journals (Sweden)

    Liliane Ibrahim

    2008-12-01

    Full Text Available Este trabalho objetivou caracterizar um sistema de solos, evidenciando a propriedades que possam esclarecer sua dinâmica e contribuir para a definição de critérios que condicionem a aptidão destes solos como receptores de efluentes. Trata-se de uma área experimental de estudos, contígua à Estação de Tratamento de Esgoto do município de Lins (SP, onde o efluente é gerado a partir do tratamento de esgoto por sistema de lagoas de estabilização. Os solos, situados ao longo de uma vertente com ligeira inclinação, foram caracterizados por meio de análises, morfológica, granulométrica, química, mineralógica e micromorfológica, realizadas em amostras coletadas em cinco trincheiras em toposseqüência. Os solos são desenvolvidos a partir dos sedimentos arenosos da Formação Adamantina (Grupo Bauru e constituem um sistema Latossolo - Argissolo onde a transição Bw - Bt ocorre lateralmente do topo para a base da vertente. Foram identificadas três fases pedogenéticas nesta associação de solos. A primeira, argiluviação e adensamento de partículas, responsável pela formação dos horizontes texturais, foi superposta pelos processos de latossolização e hidromorfismo, atuantes na dinâmica atual destes solos. Análises micromorfológicas mostraram tratar-se de solos com intensa porosidade, caracterizada pelo empilhamento dos grãos do esqueleto quartzoso amplamente predominante e pelo arranjo entre os microagregados granulares. A permeabilidade é ainda favorecida pela intensa ação da mesofauna. Os solos são distróficos e compostos por caulinita e óxidos de Fe na fração argilosa. Por constituírem um sistema frágil, a disposição de quaisquer tipos de resíduos nestes solos requer o monitoramento constante de suas propriedades, tanto para a manutenção, quanto para a recuperação da qualidade desta cobertura pedológica.The purpose of this study was the characterization of a soil system, focused on proprieties that

  2. Properties of the fullerene C_6_0-containing PN Lin49 in the SMC; Explanations of strong near-IR excess

    International Nuclear Information System (INIS)

    Otsuka, Masaaki; Kemper, Francisca; Leal-Ferreira, Marcelo L.; Aleman, Isabel; Ochsendorf, Bram; Bernard-Salas, Jeronimo; Cami, Jan; Peeters, Els

    2016-01-01

    We performed a detailed spectroscopic analysis of the fullerene C_6o-containing planetary nebula (PN) Lin49 in the Small Magellanic Cloud (SMC). Lin49 is a C-rich and metal- deficient PN (Z∼⃒0.0006) and its nebular abundances are in agreement with the AGB model for the initially 1.25M_☉ stars with the metallicity Z = 0.001 of Fishlock et al. (2014, [1]). By stellar absorption fitting with TLUSTY, we derived stellar abundances, effective temperature, and surface gravity. We constructed the photo-ionization model with CLOUDY in order to investigate physical conditions of Lin49. The model with the 0.005-0.1 μm radius graphite and a constant hydrogen density shell could not fit the ∼⃒1-5 μm SED owing to the strong near-IR excess. We propose that the near-IR excess indicates (1) the presence of extremely small carbon molecules or (2) the presence of high-density structure surrounding the central star. (paper)

  3. Initial results on computational performance of Intel Many Integrated Core (MIC) architecture: implementation of the Weather and Research Forecasting (WRF) Purdue-Lin microphysics scheme

    Science.gov (United States)

    Mielikainen, Jarno; Huang, Bormin; Huang, Allen H.

    2014-10-01

    Purdue-Lin scheme is a relatively sophisticated microphysics scheme in the Weather Research and Forecasting (WRF) model. The scheme includes six classes of hydro meteors: water vapor, cloud water, raid, cloud ice, snow and graupel. The scheme is very suitable for massively parallel computation as there are no interactions among horizontal grid points. In this paper, we accelerate the Purdue Lin scheme using Intel Many Integrated Core Architecture (MIC) hardware. The Intel Xeon Phi is a high performance coprocessor consists of up to 61 cores. The Xeon Phi is connected to a CPU via the PCI Express (PICe) bus. In this paper, we will discuss in detail the code optimization issues encountered while tuning the Purdue-Lin microphysics Fortran code for Xeon Phi. In particularly, getting a good performance required utilizing multiple cores, the wide vector operations and make efficient use of memory. The results show that the optimizations improved performance of the original code on Xeon Phi 5110P by a factor of 4.2x. Furthermore, the same optimizations improved performance on Intel Xeon E5-2603 CPU by a factor of 1.2x compared to the original code.

  4. EDITORIAL: Editorial from the new Editor-in-Chief for 2014 Editorial from the new Editor-in-Chief for 2014

    Science.gov (United States)

    Graham, W. G.

    2014-02-01

    I am honoured to take on the leadership of Plasma Sources Science and Technology (PSST) as the successor to Professor Mark J Kushner, with whom I have had the pleasure to work on the journal for many years. Under Mark's insightful and energetic leadership over the last six years, PSST has cemented its position as the journal of choice within its subject area and is now one of the most successful journals in the field. In this first issue of 2014, I would like to reflect on some of the events and achievements of 2013. At the start of the year the PSST Editorial Board, recognizing the vital importance of atomic, molecular and optical (AMO) data to low-temperature plasma physics, agreed that PSST would accept papers reporting such new data, generated through both experiment and theory. Jonathan Tennyson joined the Editorial Board to represent this area. In March Anne Bourdon joined the Associate Editor team and has since then played a key part in the journal's review process alongside our other Editors. During the autumn, PSST moved to a new editorial management system. In December Deborah O'Connell was awarded the 2013 Hershkowitz Early Career Award and Review and joins the Editorial Board as of 2014. I would also like to thank Miles Turner for his work in leading the drafting of a guide on the details necessary in the reporting of the results of computer simulations; the main conclusions of this report have been incorporated into the journal policy. Overall 2013 has been another successful year for PSST; paper submissions were up by 8% on the previous year and there was the highest ever number of downloads of PSST papers in one year. Another noteworthy feature of 2013 was the continuing improvement in publication times while maintaining our high standards for acceptance and providing expert feedback coupled with encouragement particularly to younger researchers and groups. Largely as a result of the hard work of our referees and Associate Editors, the average time

  5. Association between vitamin D receptor gene polymorphism (TaqI ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 94; Issue 3. Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. Hui-Ru Fan Li-Qun Lin Hao Ma Ying Li Chang-Hao Sun. Research Note Volume 94 Issue 3 September 2015 pp 473-478 ...

  6. Association between vitamin D receptor gene polymorphism (TaqI)

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 94; Issue 3. Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. Hui-Ru Fan Li-Qun Lin Hao Ma Ying Li Chang-Hao Sun. Research Note Volume 94 Issue 3 September 2015 pp 473-478 ...

  7. Guidelines, editors, pharma and the biological paradigm shift.

    Science.gov (United States)

    Singh, Ajai R; Singh, Shakuntala A

    2007-01-01

    relatively recent survey of 2002, it was found that about 60% of 192 authors of clinical practice guidelines reported they had financial connections with the companies whose drugs were under consideration. There is a strong case for making CPGs based not just on effectivity but cost effectivity. The various ramifications of this need to be spelt out. Work of bodies like the Appraisal of Guidelines Research and Evaluation (AGREE) Collaboration and Guidelines Advisory Committee (GAC) are also worth a close look.Even the actions of Foundations that work for disease amelioration have come under scrutiny. The process of setting up 'Best Practices' Guidelines for interactions between the pharmaceutical industry and clinicians has already begun and can have important consequences for patient care. Similarly, Good Publication Practice (GPP) for pharmaceutical companies have also been set up aimed at improving the behaviour of drug companies while reporting drug trialsThe rapidly increasing trend toward influence and control by industry has become a concern for many. It is of such importance that the Association of American Medical Colleges has issued two relatively new documents - one, in 2001, on how to deal with individual conflicts of interest; and the other, in 2002, on how to deal with institutional conflicts of interest in the conduct of clinical research. Academic Medical Centers (AMCs), as also medical education and research institutions at other places, have to adopt means that minimize their conflicts of interest.Both medical associations and research journal editors are getting concerned with individual and institutional conflicts of interest in the conduct of clinical research and documents are now available which address these issues. The 2001 ICMJE revision calls for full disclosure of the sponsor's role in research, as well as assurance that the investigators are independent of the sponsor, are fully accountable for the design and conduct of the trial, have

  8. 77 FR 74175 - Solicitation of Review Editors for the Draft Report of the National Climate Assessment and...

    Science.gov (United States)

    2012-12-13

    ... Climate Change Science; The NCA Long-Term Process. Dated: December 6, 2012. Jason Donaldson, Chief Financial Officer/Chief Administrative Officer, Office of Oceanic and Atmospheric Research, National Oceanic... Assessment 2013 Draft Report. Review Editor Role In the NCA Process: One Review Editor for each NCA 2013...

  9. Effects of gamma radiation on various stages in the life cycle of meal worm, Tenebrio molitor Lin

    International Nuclear Information System (INIS)

    Chiravathanapong, S.; Segsarnviriya, S.

    1984-12-01

    Effect of gamma radiation on each growth stage of meal worm (Tenebrio molitor Lin.) were conducted at 27+-2 0 C and 75+-2% relative humidity. LD 50 and LD 99 of 5-day old eggs at 5 days after irradiation were 76 and 367 gray. The survived larvae could live no longer than 5 days and seldom moved or without feeding. LD 50 and LD 99 of last instar larvae at 10 days after irradiation were 662 and 1,367 gray. No pupation occurred in larvae after irradiation. Dead larvae caused by radiation turned blackish, liquid oozed out from the body, and survived no longer than 5 days. Some irradiated larvae had incomplete molting and died. LD 50 and LD 99 of 6-day-old pupae at 3 days after irradiation were 874 and 1,492 gray. Abnormal irradiated pupae, some abnormal pupae were underdeveloped wing and abdominal pupal characteristic was still remained. Pupal legs could develop to adult legs only and could survive no longer than 1 week. Unfortunately pupae irradiated at low dosage of radiation would develop to be complete adult head, but could survive no longer than 2 weeks with slow movement and no oviposition. LD 50 of male adults and female adults was checked in 7 days postirradiation and it was estimated as 788 and 786 gray while LD 99 was estimated as 1,375 and 1,350 gray respectively. Results of male adults and female adults checking in 10 days post-irradiation found that LD 50 was estimated as 533 and 598 gray and LD 99 was estimated as 1,227 and 1,229 gray respectively. The remained survivors of both sexes could survive no longer than 10 days without feeding and mating

  10. Lithology identification of aquifers from geophysical well logs and fuzzy logic analysis: Shui-Lin Area, Taiwan

    Science.gov (United States)

    Hsieh, Bieng-Zih; Lewis, Charles; Lin, Zsay-Shing

    2005-04-01

    The purpose of this study is to construct a fuzzy lithology system from well logs to identify formation lithology of a groundwater aquifer system in order to better apply conventional well logging interpretation in hydro-geologic studies because well log responses of aquifers are sometimes different from those of conventional oil and gas reservoirs. The input variables for this system are the gamma-ray log reading, the separation between the spherically focused resistivity and the deep very-enhanced resistivity curves, and the borehole compensated sonic log reading. The output variable is groundwater formation lithology. All linguistic variables are based on five linguistic terms with a trapezoidal membership function. In this study, 50 data sets are clustered into 40 training sets and 10 testing sets for constructing the fuzzy lithology system and validating the ability of system prediction, respectively. The rule-based database containing 12 fuzzy lithology rules is developed from the training data sets, and the rule strength is weighted. A Madani inference system and the bisector of area defuzzification method are used for fuzzy inference and defuzzification. The success of training performance and the prediction ability were both 90%, with the calculated correlation of training and testing equal to 0.925 and 0.928, respectively. Well logs and core data from a clastic aquifer (depths 100-198 m) in the Shui-Lin area of west-central Taiwan are used for testing the system's construction. Comparison of results from core analysis, well logging and the fuzzy lithology system indicates that even though the well logging method can easily define a permeable sand formation, distinguishing between silts and sands and determining grain size variation in sands is more subjective. These shortcomings can be improved by a fuzzy lithology system that is able to yield more objective decisions than some conventional methods of log interpretation.

  11. Mentoring for text editors: Fit for purpose in the era of freelancing ...

    African Journals Online (AJOL)

    Kate H

    distinguishing between mentoring, coaching, counselling, teaching and training as ... Group (now Guild), Society for Editors and Proofreaders), a number of .... In essence, Bandura (1982) and others have found that an individual's ..... significant difference in the quality of learning or overall satisfaction when people engage.

  12. Sharing Clinical Trial Data – A Proposal from the International Committee of Medical Journal Editors

    Directory of Open Access Journals (Sweden)

    Darren B. Taichman

    2016-06-01

    Full Text Available El Comité Internacional de Editores de Revistas Mé-dicas (ICMJE, por sus siglas en inglés considera que es una obligación ética compartir, de forma respon- sable, los datos generados por los ensayos clínicos, porque los participantes se han puesto en riesgo para ello.

  13. Esthetic or Functional, Saccharine or Shocking? An Editor Looks at Values in Children's Books.

    Science.gov (United States)

    Giblin, James Cross

    1977-01-01

    Discusses artistic or esthetic, social and cultural, functional, and commercial values looked for by children's book editors in selecting and publishing manuscripts. Also reviews changes in social and cultural values as shown by children's books published in 1947, 1957, and 1967. (GT)

  14. University-government relationships in the training of technical writers-editors

    Science.gov (United States)

    Stohrer, Freda F.; Pinelli, Thomas E.

    1979-01-01

    Traditional and nontraditional methods of training technical writers-editors are reviewed. Combining work experience with classroom instruction in the form of cooperative education provides a method of strengthening the Federal career service in professional occupations. The NASA Langley experience that successfully introduced students to the special demands of technical writing and editing is described.

  15. Letter to the Editor: Chikungunya Virus Infection—An Update on Chronic Rheumatism in Latin America

    Directory of Open Access Journals (Sweden)

    Alfonso J. Rodriguez-Morales

    2017-01-01

    Full Text Available To the Editor, The article of Krutikov and Manson1 was interesting. However, no comment was made on the impact and related clinical epidemiology of the chikungunya virus (CHIKV infection during the 2014–2015 epidemics in Latin America, the most recent area affected by CHIKV. ...

  16. An International Call for Democratizing the Academic Journal Culture from a Community of Editors

    Science.gov (United States)

    Mullen, Carol A.; Pryor, Caroline R.; Browne-Ferrigno, Tricia; Harris, Sandra L.

    2013-01-01

    In our reflective essay from our multiple perspectives as journal editors, peer reviewers, and published authors, we present ideas about editorial support, democracy, and innovation in the publishing process. As four tenured professors who work in universities in the states of Illinois, Virginia, Texas, and Kentucky, we are a community of editors…

  17. Editorial: Conflict of interest policy for Editors of The American Journal of Clinical Nutrition

    Science.gov (United States)

    Integrity in the publication process requires impartiality at all levels of review. The American Journal of Clinical Nutrition (AJCN) adheres to the policy of the International Committee of Medical Journal Editors (ICMJE), Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writin...

  18. Mentoring for text editors: Fit for purpose in the era of freelancing ...

    African Journals Online (AJOL)

    In this article, the supportive role that mentoring relationships currently do and should play in the development and careers of text editors is described against the background of the particular circumstances of these service providers in a sector experiencing great organisational and technological changes. This is a group ...

  19. Effective gene editing by high-fidelity base editor 2 in mouse zygotes

    Directory of Open Access Journals (Sweden)

    Puping Liang

    2017-06-01

    Full Text Available ABSTRACT Targeted point mutagenesis through homologous recombination has been widely used in genetic studies and holds considerable promise for repairing disease-causing mutations in patients. However, problems such as mosaicism and low mutagenesis efficiency continue to pose challenges to clinical application of such approaches. Recently, a base editor (BE system built on cytidine (C deaminase and CRISPR/Cas9 technology was developed as an alternative method for targeted point mutagenesis in plant, yeast, and human cells. Base editors convert C in the deamination window to thymidine (T efficiently, however, it remains unclear whether targeted base editing in mouse embryos is feasible. In this report, we generated a modified high-fidelity version of base editor 2 (HF2-BE2, and investigated its base editing efficacy in mouse embryos. We found that HF2-BE2 could convert C to T efficiently, with up to 100% biallelic mutation efficiency in mouse embryos. Unlike BE3, HF2-BE2 could convert C to T on both the target and non-target strand, expanding the editing scope of base editors. Surprisingly, we found HF2-BE2 could also deaminate C that was proximal to the gRNA-binding region. Taken together, our work demonstrates the feasibility of generating point mutations in mouse by base editing, and underscores the need to carefully optimize base editing systems in order to eliminate proximal-site deamination.

  20. How Well Do Americans Know Geography? "National Geographic" Editor Discusses Meaning for Schools (Interview).

    Science.gov (United States)

    Koerner, Thomas

    1987-01-01

    Gilbert Grosvenor, editor of "National Geographic," is interviewed about the importance of geography for Americans. He claims our lack of geographic knowledge impedes our ability to act and compete in the world market as a world power and points out that geographic ignorance extends to people employed at high levels of government. (MD)

  1. Learning the Attachment Theory with the CM-ED Concept Map Editor

    Science.gov (United States)

    Rueda, U.; Arruarte, A.; Elorriaga, J. A.; Herran, E.

    2009-01-01

    This paper presents a study carried out at the University of the Basque Country UPV/EHU with the aim of evaluating the CM-ED (concept map editor) with social education students. Concept mapping is a widely accepted technique that promotes meaningful learning. Graphically representing concepts of the learning domain and relationships between them…

  2. Views of Reference List Accuracy from Social Work Journal Editors and Published Authors

    Directory of Open Access Journals (Sweden)

    Scott E. Wilks

    2004-12-01

    Full Text Available Objective:The study’s purpose was to answer two research questions: (1 In the opinion of social work journal editors, how important is reference list accuracy? and (2Who is primarily responsible for the accuracy of reference lists published in social work journals? Method: A sample of 119 authors and 26 journal editors was surveyed to ascertain their views on the above questions and additional items. Results: Regarding the importance of reference list accuracy, editors’ responses (Likert scale averaged between moderately and extremely important. Fifty-three percent of responding editors and 36.5% of authors reported that responsibility is shared between the editor/staff and manuscript authors; the remaining 47% and 63.5%, respectively, responded that responsibility falls upon manuscript authors. Responses from authors, mostly educators, revealed a greater-than-moderate importance (Likert scale given to instructing students on the accurate construction of reference lists. Implications for social work education and journal publishing are discussed.

  3. Advertisement for the position of “Copy Editor cum Proof Reader ...

    Indian Academy of Sciences (India)

    user

    Advertisement for the position of “Copy Editor cum. Proof Reader”. Indian Academy of Sciences (IASc), an institution under the. Department of Science & Technology, Government of India publishes scholarly journals, thematic books and other publications. The. Academy currently publishes 10 journals in various disciplines ...

  4. Why do we need international standards on responsible research publication for authors and editors?

    Directory of Open Access Journals (Sweden)

    Elizabeth Wager

    2013-12-01

    Full Text Available Delivering the best possible healthcare requires a reliable evidence-base of research publications. Both authors and editors have responsibilities when publishing research yet it can be hard to find guidance on these. Most journal instructions concentrate on style and formatting but give little or no information about research and publication ethics.

  5. Why do we need international standards on responsible research publication for authors and editors?

    OpenAIRE

    Wager, Elizabeth; Kleinert, Sabine

    2013-01-01

    Delivering the best possible healthcare requires a reliable evidence-base of research publications. Both authors and editors have responsibilities when publishing research yet it can be hard to find guidance on these. Most journal instructions concentrate on style and formatting but give little or no information about research and publication ethics.

  6. FlaME: Flash Molecular Editor - a 2D structure input tool for the web

    Directory of Open Access Journals (Sweden)

    Dallakian Pavel

    2011-02-01

    Full Text Available Abstract Background So far, there have been no Flash-based web tools available for chemical structure input. The authors herein present a feasibility study, aiming at the development of a compact and easy-to-use 2D structure editor, using Adobe's Flash technology and its programming language, ActionScript. As a reference model application from the Java world, we selected the Java Molecular Editor (JME. In this feasibility study, we made an attempt to realize a subset of JME's functionality in the Flash Molecular Editor (FlaME utility. These basic capabilities are: structure input, editing and depiction of single molecules, data import and export in molfile format. Implementation The result of molecular diagram sketching in FlaME is accessible in V2000 molfile format. By integrating the molecular editor into a web page, its communication with the HTML elements on this page is established using the two JavaScript functions, getMol( and setMol(. In addition, structures can be copied to the system clipboard. Conclusion A first attempt was made to create a compact single-file application for 2D molecular structure input/editing on the web, based on Flash technology. With the application examples presented in this article, it could be demonstrated that the Flash methods are principally well-suited to provide the requisite communication between the Flash object (application and the HTML elements on a web page, using JavaScript functions.

  7. Associate Professor Jan Brandts, editor-in-chief of Applications of Mathematics, is fifty

    Czech Academy of Sciences Publication Activity Database

    Křížek, Michal

    2018-01-01

    Roč. 63, č. 1 (2018), s. 1-5 ISSN 0862-7940 Institutional support: RVO:67985840 Keywords : editor-in-chief Subject RIV: BA - General Mathematics Impact factor: 0.618, year: 2016 http:// articles .math.cas.cz/10.21136/AM.2018.0326-17/?type=F

  8. Associate Professor Jan Brandts, editor-in-chief of Applications of Mathematics, is fifty

    Czech Academy of Sciences Publication Activity Database

    Křížek, Michal

    2018-01-01

    Roč. 63, č. 1 (2018), s. 1-5 ISSN 0862-7940 Institutional support: RVO:67985840 Keywords : editor-in-chief Subject RIV: BA - General Mathematics Impact factor: 0.618, year: 2016 http://articles.math.cas.cz/10.21136/AM.2018.0326-17/?type=F

  9. Extended Hu¨ckel Calculations on Solids Using the Avogadro Molecular Editor and Visualizer

    Science.gov (United States)

    Avery, Patrick; Ludoweig, Herbert; Autschbach, Jochen; Zurek, Eva

    2018-01-01

    The "Yet Another extended Hu¨ckel Molecular Orbital Package" (YAeHMOP) has been merged with the Avogadro open-source molecular editor and visualizer. It is now possible to perform YAeHMOP calculations directly from the Avogadro graphical user interface for materials that are periodic in one, two, or three dimensions, and to visualize…

  10. IMPLEMENTASI EDITOR MODEL DATA KONSEPTUAL DAN MODEL DATA FISIK DENGAN ROUND-TRIP ENGINEERING

    Directory of Open Access Journals (Sweden)

    Aldy Sefan Rezanaldy

    2012-01-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Desain model basis data merupakan sebuah fase penting dalam pengembangan sebuah Aplikasi Sistem Informasi. Editor Model Data yang digunakan untuk melakukan desain basis data sangat diperlukan dalam dunia IT. Sebagian Editor yang ada saat ini belum menerapkan konsep round-trip engineering secara real time, sehingga perubahan yang terjadi pada satu data model membutuhkan event update untuk melakukan pembaharuan pada model data yang lainnya. Editor model data ini merupakan editor dengan round-trip engineering. Konversi bolak-balik dilakukan antara data model konseptual dan data model fisik. Editor ini dikembangkan dengan menggunakan C# .NET Framework dan implementasi desain pola pada Object Oriented. Dalam implementasi sebuah editor, yang merupakan bagian terpenting selain berjalannya seluruh fitur yang ada adalah tentang performa dan kenyamanan user ketika menggunakannya. Performa dan kenyamanan user menjadi penilaian tersendiri pada sebuah editor model data. Aplikasi yang dihasilkan diharapkan dapat digunakan untuk melakukan desain basis data dengan menerapkan metode konversi bolak-balik, sehingga tidak diperlukan proses perbaruan dari model data yang satu ke model data yang lain secara manual. Diharapkan dapat

  11. Correction of β-thalassemia mutant by base editor in human embryos

    Directory of Open Access Journals (Sweden)

    Puping Liang

    2017-09-01

    Full Text Available Abstract β-Thalassemia is a global health issue, caused by mutations in the HBB gene. Among these mutations, HBB −28 (A>G mutations is one of the three most common mutations in China and Southeast Asia patients with β-thalassemia. Correcting this mutation in human embryos may prevent the disease being passed onto future generations and cure anemia. Here we report the first study using base editor (BE system to correct disease mutant in human embryos. Firstly, we produced a 293T cell line with an exogenous HBB −28 (A>G mutant fragment for gRNAs and targeting efficiency evaluation. Then we collected primary skin fibroblast cells from a β-thalassemia patient with HBB −28 (A>G homozygous mutation. Data showed that base editor could precisely correct HBB −28 (A>G mutation in the patient’s primary cells. To model homozygous mutation disease embryos, we constructed nuclear transfer embryos by fusing the lymphocyte or skin fibroblast cells with enucleated in vitro matured (IVM oocytes. Notably, the gene correction efficiency was over 23.0% in these embryos by base editor. Although these embryos were still mosaic, the percentage of repaired blastomeres was over 20.0%. In addition, we found that base editor variants, with narrowed deamination window, could promote G-to-A conversion at HBB −28 site precisely in human embryos. Collectively, this study demonstrated the feasibility of curing genetic disease in human somatic cells and embryos by base editor system.

  12. Scientific value of systematic reviews: survey of editors of core clinical journals.

    Directory of Open Access Journals (Sweden)

    Joerg J Meerpohl

    Full Text Available BACKGROUND: Synthesizing research evidence using systematic and rigorous methods has become a key feature of evidence-based medicine and knowledge translation. Systematic reviews (SRs may or may not include a meta-analysis depending on the suitability of available data. They are often being criticised as 'secondary research' and denied the status of original research. Scientific journals play an important role in the publication process. How they appraise a given type of research influences the status of that research in the scientific community. We investigated the attitudes of editors of core clinical journals towards SRs and their value for publication. METHODS: We identified the 118 journals labelled as "core clinical journals" by the National Library of Medicine, USA in April 2009. The journals' editors were surveyed by email in 2009 and asked whether they considered SRs as original research projects; whether they published SRs; and for which section of the journal they would consider a SR manuscript. RESULTS: The editors of 65 journals (55% responded. Most respondents considered SRs to be original research (71% and almost all journals (93% published SRs. Several editors regarded the use of Cochrane methodology or a meta-analysis as quality criteria; for some respondents these criteria were premises for the consideration of SRs as original research. Journals placed SRs in various sections such as "Review" or "Feature article". Characterization of non-responding journals showed that about two thirds do publish systematic reviews. DISCUSSION: Currently, the editors of most core clinical journals consider SRs original research. Our findings are limited by a non-responder rate of 45%. Individual comments suggest that this is a grey area and attitudes differ widely. A debate about the definition of 'original research' in the context of SRs is warranted.

  13. QUALIDADE DE CONTEÚDO, O GRANDE DESAFIO PARA OS EDITORES CIENTÍFICOS/ CALIDAD DEL CONTENIDO, EL GRAN DESAFÍO PARA LOS EDITORES CIENTÍFICOS/ QUALITY OF CONTENT, THE GREAT CHALLENGE FOR SCIENTIFIC EDITORS

    Directory of Open Access Journals (Sweden)

    Tatiana Plata-Caviedes

    2012-07-01

    Full Text Available Discutem-se alguns problemas que atualmente afetam a qualidade do conteúdo das revistas científicas e ressalta-se o papel dos editores como responsáveis pela definição tanto da direção (o que se fará como da profundidade (até que ponto se avançará das pesquisas. Propõe-se que a relação ótima entre ambas se alcança a partir de um equilíbrio entre as três logias: terminologia, epistemologia e metodologia. Sob esta fundamentação, apresenta-se uma taxonomia para avaliação e análise de projetos de pesquisa, artigos e pareceres científicos. Conclui-se com propostas de ação específicas para todos os atores envolvidos na geração e difusão do conhecimento (autores, revisores, agências de fomento, instituições que publicam revistas e editores científicos, orientadas a melhorar a qualidade do conteúdo das publicações.

  14. Gene expression profile and functionality of ESC-derived Lin-ckit+Sca-1+ cells are distinct from Lin-ckit+Sca-1+ cells isolated from fetal liver or bone marrow.

    Directory of Open Access Journals (Sweden)

    Irina Fernandez

    Full Text Available In vitro bioreactor-based cultures are being extensively investigated for large-scale production of differentiated cells from embryonic stem cells (ESCs. However, it is unclear whether in vitro ESC-derived progenitors have similar gene expression profiles and functionalities as their in vivo counterparts. This is crucial in establishing the validity of ESC-derived cells as replacements for adult-isolated cells for clinical therapies. In this study, we compared the gene expression profiles of Lin-ckit+Sca-1+ (LKS cells generated in vitro from mouse ESCs using either static or bioreactor-based cultures, with that of native LKS cells isolated from mouse fetal liver (FL or bone marrow (BM. We found that in vitro-generated LKS cells were more similar to FL- than to BM LKS cells in gene expression. Further, when compared to cells derived from bioreactor cultures, static culture-derived LKS cells showed fewer differentially expressed genes relative to both in vivo LKS populations. Overall, the expression of hematopoietic genes was lower in ESC-derived LKS cells compared to cells from BM and FL, while the levels of non-hematopoietic genes were up-regulated. In order to determine if these molecular profiles correlated with functionality, we evaluated ESC-derived LKS cells for in vitro hematopoietic-differentiation and colony formation (CFU assay. Although static culture-generated cells failed to form any colonies, they did differentiate into CD11c+ and B220+ cells indicating some hematopoietic potential. In contrast, bioreactor-derived LKS cells, when differentiated under the same conditions failed to produce any B220+ or CD11c+ cells and did not form colonies, indicating that these cells are not hematopoietic progenitors. We conclude that in vitro culture conditions significantly affect the transcriptome and functionality of ESC-derived LKS cells and although in vitro differentiated LKS cells were lineage negative and expressed both ckit and Sca-1

  15. ALLIUM HOOKERII LIN

    African Journals Online (AJOL)

    Toshiba

    increase the food supply and add variety to the diet [5]. ... available in the Himalayan range including Nepal, China [6]. ... altitude, between 93.42oE to 94.47oE longitude and between 23.83 o ... The leaf decoction (Decoction is a method of extraction, by boiling, or ..... Dry fish washed in water are fried in a small amount of.

  16. Lin Simpson | NREL

    Science.gov (United States)

    technology areas that included: nanotechnology, nanomaterials, thin-film photovoltaics, thin-film processing , and program management. This includes extensive experience in nanotechnology, materials science B.S., Engineering Physics, Colorado School of Mines. Thesis: Spatial filtering for pattern recognition

  17. Temporal variation and source identification of black carbon at Lin'an and Longfengshan regional background stations in China

    Science.gov (United States)

    Cheng, Siyang; Wang, Yaqiang; An, Xingqin

    2017-12-01

    Black carbon (BC) is a component of fine particulate matter (PM2.5), associated with climate, weather, air quality, and people's health. However, studies on temporal variation of atmospheric BC concentration at background stations in China and its source area identification are lacking. In this paper, we use 2-yr BC observations from two background stations, Lin'an (LAN) and Longfengshan (LFS), to perform the investigation. The results show that the mean diurnal variation of BC has two significant peaks at LAN while different characteristics are found in the BC variation at LFS, which are probably caused by the difference in emission source contributions. Seasonal variation of monthly BC shows double peaks at LAN but a single peak at LFS. The annual mean concentrations of BC at LAN and LFS decrease by 1.63 and 0.26 μg m-3 from 2009 to 2010, respectively. The annual background concentration of BC at LAN is twice higher than that at LFS. The major source of the LAN BC is industrial emission while the source of the LFS BC is residential emission. Based on transport climatology on a 7-day timescale, LAN and LFS stations are sensitive to surface emissions respectively in belt or approximately circular area, which are dominated by summer monsoon or colder land air flows in Northwest China. In addition, we statistically analyze the BC source regions by using BC observation and FLEXible PARTicle dispersion model (FLEXPART) simulation. In summer, the source regions of BC are distributed in the northwest and south of LAN and the southwest of LFS. Low BC concentration is closely related to air mass from the sea. In winter, the source regions of BC are concentrated in the west and south of LAN and the northeast of the threshold area of s tot at LFS. The cold air mass in the northwest plays an important role in the purification of atmospheric BC. On a yearly scale, sources of BC are approximately from five provinces in the northwest/southeast of LAN and the west of LFS. These

  18. N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b.

    Directory of Open Access Journals (Sweden)

    Rebecca Cotterman

    2009-06-01

    Full Text Available myc genes are best known for causing tumors when overexpressed, but recent studies suggest endogenous myc regulates pluripotency and self-renewal of stem cells. For example, N-myc is associated with a number of tumors including neuroblastoma, but also plays a central role in the function of normal neural stem and precursor cells (NSC. Both c- and N-myc also enhance the production of induced pluripotent stem cells (iPSC and are linked to neural tumor stem cells. The mechanisms by which myc regulates normal and neoplastic stem-related functions remain largely open questions. Here from a global, unbiased search for N-Myc bound genes using ChIP-chip assays in neuroblastoma, we found lif as a putative N-Myc bound gene with a number of strong N-Myc binding peaks in the promoter region enriched for E-boxes. Amongst putative N-Myc target genes in expression microarray studies in neuroblastoma we also found lif and three additional important embryonic stem cell (ESC-related factors that are linked to production of iPSC: klf2, klf4, and lin28b. To examine the regulation of these genes by N-Myc, we measured their expression using neuroblastoma cells that contain a Tet-regulatable N-myc transgene (TET21N as well as NSC with a nestin-cre driven N-myc knockout. N-myc levels closely correlated with the expression of all of these genes in neuroblastoma and all but lif in NSC. Direct ChIP assays also indicate that N-Myc directly binds the lif promoter. N-Myc regulates trimethylation of lysine 4 of histone H3 in the promoter of lif and possibly in the promoters of several other stem-related genes. Together these findings indicate that N-Myc regulates overlapping stem-related gene expression programs in neuroblastoma and NSC, supporting a novel model by which amplification of the N-myc gene may drive formation of neuroblastoma. They also suggest mechanisms by which Myc proteins more generally contribute to maintenance of pluripotency and self-renewal of ESC as

  19. An editor for the maintenance and use of a bank of contracted Gaussian basis set functions

    International Nuclear Information System (INIS)

    Taurian, O.E.

    1984-01-01

    A bank of basis sets to be used in ab-initio calculations has been created. The bases are sets of contracted Gaussian type orbitals to be used as input to any molecular integral package. In this communication we shall describe the organization of the bank and a portable editor program which was designed for its maintenance and use. This program is operated by commands and it may be used to obtain any kind of information about the bases in the bank as well as to produce output to be directly used as input for different integral programs. The editor may also be used to format basis sets in the conventional way utilized in publications, as well as to generate a complete, or partial, manual of the contents of the bank if so desired. (orig.)

  20. Artificial intelligence in peer review: How can evolutionary computation support journal editors?

    Science.gov (United States)

    Mrowinski, Maciej J; Fronczak, Piotr; Fronczak, Agata; Ausloos, Marcel; Nedic, Olgica

    2017-01-01

    With the volume of manuscripts submitted for publication growing every year, the deficiencies of peer review (e.g. long review times) are becoming more apparent. Editorial strategies, sets of guidelines designed to speed up the process and reduce editors' workloads, are treated as trade secrets by publishing houses and are not shared publicly. To improve the effectiveness of their strategies, editors in small publishing groups are faced with undertaking an iterative trial-and-error approach. We show that Cartesian Genetic Programming, a nature-inspired evolutionary algorithm, can dramatically improve editorial strategies. The artificially evolved strategy reduced the duration of the peer review process by 30%, without increasing the pool of reviewers (in comparison to a typical human-developed strategy). Evolutionary computation has typically been used in technological processes or biological ecosystems. Our results demonstrate that genetic programs can improve real-world social systems that are usually much harder to understand and control than physical systems.

  1. Artificial intelligence in peer review: How can evolutionary computation support journal editors?

    Directory of Open Access Journals (Sweden)

    Maciej J Mrowinski

    Full Text Available With the volume of manuscripts submitted for publication growing every year, the deficiencies of peer review (e.g. long review times are becoming more apparent. Editorial strategies, sets of guidelines designed to speed up the process and reduce editors' workloads, are treated as trade secrets by publishing houses and are not shared publicly. To improve the effectiveness of their strategies, editors in small publishing groups are faced with undertaking an iterative trial-and-error approach. We show that Cartesian Genetic Programming, a nature-inspired evolutionary algorithm, can dramatically improve editorial strategies. The artificially evolved strategy reduced the duration of the peer review process by 30%, without increasing the pool of reviewers (in comparison to a typical human-developed strategy. Evolutionary computation has typically been used in technological processes or biological ecosystems. Our results demonstrate that genetic programs can improve real-world social systems that are usually much harder to understand and control than physical systems.

  2. A Java Chemical Structure Editor Supporting the Modular Chemical Descriptor Language (MCDL

    Directory of Open Access Journals (Sweden)

    Andrei A. Gakh

    2006-03-01

    Full Text Available A compact Modular Chemical Descriptor Language (MCDL chemical structure editor (Java applet is described. The small size (approximately 200 KB of the applet allows its use to display and edit chemical structures in various Internet applications. The editor supports the MCDL format, in which structures are presented in compact canonical form and is capable of restoring bond orders as well as of managing atom and bond drawing overlap. A small database of cage and large cyclic fragment is used for optimal representation of difficult-to-draw molecules. The improved algorithm of the structure diagram generation can be used for other chemical notations that lack atomic coordinates (SMILES, InChI.

  3. CMS Configuration Editor: GUI based application for user analysis job definition

    CERN Document Server

    De Cosa, Annapaola

    2010-01-01

    We present the user interface and the software architecture of the Configuration Editor that is used by CMS physicists to configure their physics analysis tasks. Analysis workflows typically involve execution of a sequence of algorithms, and these are implemented as software modules that are integrated within the CMS software framework (CMSSW). In particular, a set of common analysis tools is provided in the so-called CMS Physics Analysis Toolkit (PAT) and these need to be steered and configured during the execution of an analysis job. The Python scripting language is used to define the job configuration that drives the analysis workflow. Configuring analysis jobs can be quite a challenging task, particularly for newcomers, and therefore a graphical tool, called the Configuration Editor, has been developed to facilitate the creation and inspection of these configuration files. Typically, a user-defined analysis workflow can be produced starting from a standard configuration file, applying and configuring PAT ...

  4. MULTIMEDIA EDITOR OF VIRTUAL PHYSICAL LABORATORY IN DISTANCE LEARNING SYSTEM «KHERSON VIRTUAL UNIVERSITY»

    Directory of Open Access Journals (Sweden)

    Kravtsov H.

    2017-12-01

    Full Text Available The questions of modeling the structure of the objects of the system, the design of software modules and technologies for creating the editor of a virtual laboratory are considered. The relevance of the study is due to the lack in existing distance learning systems of support for the creation and use of virtual laboratory work on disciplines of the natural-science profile. The subject of the study is a software module for creating and using virtual laboratory work in a distance learning system. The purpose of the study is the development of a system model and a description of the software development technology of a virtual laboratory for physics for a distance learning system. The information technologies of designing the structure of the virtual laboratory and the main modes of the program module of the editor of the virtual laboratory work are described. At the heart of the structure of the software module "Virtual Laboratory" is the multimedia Web-editor of virtual laboratory works, which is created using object-oriented design technology. The program library of multimedia 3D objects created in the development environment of interactive graphic objects Unity3D. It unifies the process of creation and processing of virtual laboratory works. The basic mathematical package for supporting calculations is the mathematical processor Waterloo Maple. The application of the developed software interface will allow teachers to create laboratory works and use them in their distance courses. Students, in turn, will be able to conduct research, performing virtual laboratory work. As an example, the editor of the virtual laboratory for physics in the distance learning system "Kherson Virtual University" is considered.

  5. Expectations in case of event - from a television editor's point of view

    International Nuclear Information System (INIS)

    Engelhardt, H.

    1997-01-01

    Informing the public about emergencies requires two different phases a of necessary operation: (1) a pre-event culture of permanent relations and communication, training authors and editors, and footage-providing, and (2) a mobile information task force to be alerted very quickly in case of event. Special television needings and recommandations are elaborated, the legal duties of german public radio and television corporations are outlined. (orig.) [de

  6. Guest editor - Material exchanges at marine boundaries and surface ocean processes: Forcings and feedbacks

    Digital Repository Service at National Institute of Oceanography (India)

    DileepKumar, M.

    . Diffusional flux is generally used to quantify air?sea flux of a gas and the bubbling process is generally ignored. This study highlights therefore the signi- ficance of bubbles in loading the atmosphere with methane from shallow water systems. What hap- pens... Institute of Science, Bangalore) for their critical and indepth comments which enriched the qual- ity and content of the manuscripts and helped in editorial decisions. I also appreciate the support and encouragement I received from the Editors, particularly...

  7. THE USING OF GRAPHICAL EDITOR IN THE ENGINEERING GRAPHICS AND THE COURSE DESIGNING

    Directory of Open Access Journals (Sweden)

    KARPYUK L. V.

    2016-08-01

    Full Text Available The problems of learning students of the engineering and computer graphics of the course on the base of computer-aided design (CAD were described in the article. The examples of training tasks for acquiring knowledge of work in the environment of graphical editor of AutoCAD were shown. These examples are needed to perform drawings on The Engineering Graphics, and also for a graphic part of Course Projects for students of mechanical specialties.

  8. [Stanisława Adamowiczowa--first editor in-chief of Journal "Przeglad Epidemiologiczny"].

    Science.gov (United States)

    Gromulska, Marta

    2010-01-01

    First issue of Epidemiological Review was published in 1920. First editor in chief was Stanisława Adamowiczowa, PhD (1888-1965), who had worked in National Central Epidemiological Institute since 1919, and later, for period of 45 years, interrupted by breaks resulting from political situation, worked in National Institute of Hygiene. In this jubilee article, we present scientific resume of S. Adamowiczowa which focuses on her achievements in infectious diseases epidemiology, and particularly in analysis and evaluation of current epidemiological data distribution in Poland and worldwide in the period. She was the pioneer in systemic organization of registries of new cases of diseases in the highly populated Polish cities; she initiated use of statistical methods in this field. As editor in chief of Epidemiological Review, she started publishing Epidemiological Chronicle, which is continuously added as a supplement to every second issue, each year. Name of S. Adamowiczowa is associated with Ludwik Rajchman--director of Hygiene Section in League of Nations, with Witold Chodźko PhD--she led courses in National School of Hygiene in Warsaw, with prof. Marcin Kacprzak--as co-author and co-editor of books on hygiene and epidemiology. A brief list of scientific publications of S. Adamowiczowa is also presented.

  9. Real time processing of neutron monitor data using the edge editor algorithm

    Directory of Open Access Journals (Sweden)

    Mavromichalaki Helen

    2012-09-01

    Full Text Available The nucleonic component of the secondary cosmic rays is measured by the worldwide network of neutron monitors (NMs. In most cases, a NM station publishes the measured data in a real time basis in order to be available for instant use from the scientific community. The space weather centers and the online applications such as the ground level enhancement (GLE alert make use of the online data and are highly dependent on their quality. However, the primary data in some cases are distorted due to unpredictable instrument variations. For this reason, the real time primary data processing of the measured data of a station is necessary. The general operational principle of the correction algorithms is the comparison between the different channels of a NM, taking advantage of the fact that a station hosts a number of identical detectors. Median editor, Median editor plus and Super editor are some of the correction algorithms that are being used with satisfactory results. In this work an alternative algorithm is proposed and analyzed. The new algorithm uses a statistical approach to define the distribution of the measurements and introduces an error index which is used for the correction of the measurements that deviate from this distribution.

  10. Developing Integral Review:IR Editors Reflect on Meta-theory,the Concept of

    Directory of Open Access Journals (Sweden)

    Russ Volckmann

    2007-12-01

    Full Text Available Over the past three years our journey as editors of Integral Review has been full of rich learning. The processes of providing authors with feedback, going over reviews of articles as well as writing ourselves have all contributed to our growth. The primary forum for this learning has been the many conversations amongst us to deal with the various issues that arise in publishing IR. Our intention in this brief piece is to share some of our reflections on this learning journey with you. These will take the form of contributions/reflections from individual editors, allowing us to share with you the particular issues we feel of value in this process.By writing these short pieces, we aim to provide additional resources for understanding how IR works. While we have guidelines and criteria for submissions on our website, it seems that narrative voices from individuals may add some flesh to them. Relating how we perceive issues around writing for an “integral” journal offers a supplement for engaging these criteria, and will hopefully bring them to life. As well, we hope that our writing provides insights into how and what we think about issues relevant to IR’s mission. These pieces reflect the unique voices we have as editors of Integral Review, and demonstrate some of the thinking and passions behind this journal.

  11. Conflicts of interest in biomedical publications: considerations for authors, peer reviewers, and editors.

    Science.gov (United States)

    Gasparyan, Armen Yuri; Ayvazyan, Lilit; Akazhanov, Nurbek A; Kitas, George D

    2013-12-01

    This article overviews evidence on common instances of conflict of interest (COI) in research publications from general and specialized fields of biomedicine. Financial COIs are viewed as the most powerful source of bias, which may even distort citation outcomes of sponsored publications. The urge to boost journal citation indicators by stakeholders of science communication is viewed as a new secondary interest, which may compromize the interaction between authors, peer reviewers and editors. Comprehensive policies on disclosure of financial and non-financial COIs in scholarly journals are presented as proxies of their indexing in evidence-based databases, and examples of successful medical journals are discussed in detail. Reports on clinical trials, systematic reviews, meta-analyses and clinical practice guidelines may be unduly influenced by author-pharmaceutical industry relations, but these publications do not always contain explicit disclosures to allow the readers to judge the reliability of the published conclusions and practice-changing recommendations. The article emphasizes the importance of adhering to the guidance on COI from learned associations such as the International Committee of Medical Journal Editors (ICMJE). It also considers joint efforts of authors, peer reviewers and editors as a foundation for appropriately defining and disclosing potential COIs.

  12. A multifunction editor for programming control sequences for a robot based radiopharmaceutical synthesis system

    International Nuclear Information System (INIS)

    Appelquist, G.; Bohm, C.

    1990-01-01

    A Multifunction Editor is a development tool for building control sequences for a robotized production system for positron emitting radiopharmaceuticals. This system consists of SCARA robot and a PC-AT personal computer as a controller together with general and synthesis specific chemistry equipment. The general equipment, which is common for many synthesis, is fixed to the wall of the hotcell, while the specific equipment, dedicated to the given synthesis, is located on a removable tray. The program recognizes commands to move the robot, to control valves and to control the computer screen. From within the editor it is possible to run the control sequence forward or backward to test it and to use the single step feature to debug. The editor commands include insert, replace and delete of commands in the sequence. When programming or editing robot movements the robot may be controlled by the mouse, from the keyboard or from a remote control box. The robot control sequence consists of a succession of stored robot positions. The screen control is used to display dynamic flowchart diagrams. This is achieved by displaying a modified picture on the screen whenever the system state has been changed significantly

  13. Conflicts of interest in biomedical publications: considerations for authors, peer reviewers, and editors

    Science.gov (United States)

    Gasparyan, Armen Yuri; Ayvazyan, Lilit; Akazhanov, Nurbek A.; Kitas, George D.

    2013-01-01

    This article overviews evidence on common instances of conflict of interest (COI) in research publications from general and specialized fields of biomedicine. Financial COIs are viewed as the most powerful source of bias, which may even distort citation outcomes of sponsored publications. The urge to boost journal citation indicators by stakeholders of science communication is viewed as a new secondary interest, which may compromize the interaction between authors, peer reviewers, and editors. Comprehensive policies on disclosure of financial and non-financial COIs in scholarly journals are presented as proxies of their indexing in evidence-based databases, and examples of successful medical journals are discussed in detail. Reports on clinical trials, systematic reviews, meta-analyses, and clinical practice guidelines may be unduly influenced by author-pharmaceutical industry relations, but these publications do not always contain explicit disclosures to allow the readers to judge the reliability of the published conclusions and practice-changing recommendations. The article emphasizes the importance of adhering to the guidance on COI from learned associations such as the International Committee of Medical Journal Editors (ICMJE). It also considers joint efforts of authors, peer reviewers, and editors as a foundation for appropriately defining and disclosing potential COIs. PMID:24382859

  14. Differences in acetate recovery factor between groups may interfere with tracer estimates of fat oxidation (letter to the editor)

    NARCIS (Netherlands)

    dr. Lars B. Borghouts; E.E. Blaak; P. Schrauwen; A.J.M. Wagenmakers

    2001-01-01

    This letter to the editor argues that the assumption of a single value for the acetate recovery factor in carbon-13 stable isotope research for different individuals, can lead to significant errors in the outcomes of substrate utilization measurements.

  15. 2012 Special NSREC Issue of the IEEE Transactions on Nuclear Science Comments by the Editors

    Science.gov (United States)

    Schwank, Jim; Brown, Dennis; Girard, Sylvain; Gouker, Pascale; Gerardin, Simone; Quinn, Heather; Barnaby, Hugh

    2012-12-01

    The December 2012 special issue of the IEEE Transactions on Nuclear Science contains selected papers from the 49th annual IEEE International Nuclear and Space Radiation Effects Conference (NSREC) held July 16-20, 2012, in Miami, Florida USA. 95 papers presented at the 2012 NSREC were submitted for consideration for this year’s special issue. Those papers that appear in this special issue were able to successfully complete the review process before the deadline for the December issue. A few additional papers may appear in subsequent issues of the TRANSACTIONS. This publication is the premier archival journal for research on space and nuclear radiation effects in materials, devices, circuits, and systems. This distinction is the direct result of the conscientious efforts of both the authors, who present and document their work, and the reviewers, who selflessly volunteer their time and talent to help review the manuscripts. Each paper in this journal has been reviewed by experts selected by the editors for their expertise and knowledge of the particular subject areas. The peer review process for a typical technical journal generally takes six months to one year to complete. To publish this special issue of the IEEE Transactions on Nuclear Science (in December), the review process, from initial submission to final form, must be completed in about 10 weeks. Because of the short schedule, both the authors and reviewers are required to respond very quickly. The reviewers listed on the following pages contributed vitally to this quick-turn review process.We would like to express our sincere appreciation to each of them for accepting this difficult, but critical role in the process. To provide consistent reviews of papers throughout the year, the IEEE Transactions on Nuclear Science relies on a year-round editorial board that manages reviews for submissions throughout the year to the TRANSACTIONS in the area of radiation effects. The review process is managed by a Senior

  16. Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97.

    Science.gov (United States)

    Bachmann, André; Timmer, Marco; Sierralta, Jimena; Pietrini, Grazia; Gundelfinger, Eckart D; Knust, Elisabeth; Thomas, Ulrich

    2004-04-15

    Stardust (Sdt) and Discs-Large (Dlg) are membrane-associated guanylate kinases (MAGUKs) involved in the organization of supramolecular protein complexes at distinct epithelial membrane compartments in Drosophila. Loss of either Sdt or Dlg affects epithelial development with severe effects on apico-basal polarity. Moreover, Dlg is required for the structural and functional integrity of synaptic junctions. Recent biochemical and cell culture studies have revealed that various mammalian MAGUKs can interact with mLin-7/Veli/MALS, a small PDZ-domain protein. To substantiate these findings for their in vivo significance with regard to Sdt- and Dlg-based protein complexes, we analyzed the subcellular distribution of Drosophila Lin-7 (DLin-7) and performed genetic and biochemical assays to characterize its interaction with either of the two MAGUKs. In epithelia, Sdt mediates the recruitment of DLin-7 to the subapical region, while at larval neuromuscular junctions, a particular isoform of Dlg, Dlg-S97, is required for postsynaptic localization of DLin-7. Ectopic expression of Dlg-S97 in epithelia, however, was not sufficient to induce a redistribution of DLin-7. These results imply that the recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms and that DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses.

  17. Editor's intervention in the register of compounds in archaic Portuguese texts: some reflections on the use of hyphen

    Directory of Open Access Journals (Sweden)

    Antonia Vieira dos Santos

    2014-07-01

    Full Text Available The use of hyphen within compounds was not built up before the nineteenth century. Thus, compounds spelled with hyphen in archaic Portuguese texts are a result of editing criteria adopted by editors. From this type of intervention, the relationship between hyphen use – result of a spelling convention – and the definition of compound adopted by the editor are discussed. Its absence is significant to the history of the language.

  18. Editor's note

    Science.gov (United States)

    2016-02-01

    In the Invited Feature Article in this issue of Estuarine, Coastal and Shelf Science, Ruben Kosyan and Violeta Velikova describe the disastrous anthropogenic impact on the Black Sea coast of Bulgaria, Georgia, Romania, Russian Federation, Turkey, and Ukraine over the last 100 years and its inverse correlation with economic development as exemplified by improving water quality during a downturn in the economy. This degradation is now accelerating from the renovation and construction of ports and terminals, the development of resorts, hazardous industrial development, oil and gas exploration, and unsustainable agricultural and fishing practices. There appears to be no enforcement of protected areas. In the absence of scientific research on these issues, coastal zone management appears to be based on 'learning after seeing disastrous effects'. Without recognition of the need for Integrated Coastal Zone Management, the Black Sea coast and the coastal waters will deteriorate, as was observed between the 1970s and the 1990s.

  19. Editor's Introduction

    Directory of Open Access Journals (Sweden)

    V. Busacchi

    2017-12-01

    Full Text Available The twentieth century was deeply influenced by theoretical-practical and reflective developments in philosophical hermeneutics. It introduced a large range of problems, content and perspectives, on a vast referential and implicational (inter-disciplinary scale, to enter into the real orbit of a philosophical koinè, not for a decennary or few decennaries (Vattimo, but for a century and more. It expressed the productivity, significance and heuristic strength of research and thought that hit different scientific domains, particularly (but not exclusively the human and social sciences: from psychology to sociology, from psychoanalysis to literature, from semiotic to biblical exegesis, from anthropology to linguistics, from rhetoric to narratology, from history to law and from political theory to religion.

  20. Editor's Note

    African Journals Online (AJOL)

    Responding to suggestions from the research fellowship of the Institute of African Studies for a re-branding of the Research Review, which began publication in the early 1960s soon after the establishment of the Institute, the old title has now been replaced with a new title — Contemporary Journal of African Studies. This is ...

  1. Editor's Note

    African Journals Online (AJOL)

    It may be recalled that responding to suggestions from the research fellowship of the Institute of African Studies for a re-branding of the Research Review, which began publication in the early 1960s soon after the establishment of the Institute, the old title was replaced in 2012 by this new title — Contemporary Journal of ...

  2. Editor's Note

    African Journals Online (AJOL)

    It is essential to recall that responding to suggestions from the research fellowship of the Institute of African Studies for a re-branding of the Research Review, which began publication in the early 1960s soon after the establishment of the Institute, the old title has been replaced with this new title — Contemporary Journal of ...

  3. From Editor

    OpenAIRE

    Ugur Demiray

    2014-01-01

    Dear TOJDE Readers, Welcome to the volume 15 number: 1 of TOJDE, In this issue, 18 articles of 34 authors from 9 different countries around the world have been published. These published articles are arrived to the tojde from, bBangladesh, Brunei, Greece, India, Indonasia, Malaysia, Republic Of Korea, Turkey and USA. The 1st article is arrived from Grecee written by Evangelos Bebetsos and Dimitrios Goulimaris from Department of Physical Education & Sports Science, Democritus Unive...

  4. Editors' Note

    Directory of Open Access Journals (Sweden)

    Jana Cason

    2014-09-01

    Full Text Available The spring 2014 issue of the International Journal of Telerehabilitation (IJT contains four informative and timely policy articles: (1 an invited commentary describing the exploratory process underway within physical therapy to create licensure portability for physical therapists, (2 an analysis of state telehealth laws and regulations for occupational therapy and physical therapy, (3 an overview of telehealth evidence and key telehealth policy issues in occupational therapy, and (4 the World Federation of Occupational Therapists’ (WFOT Position Statement on Telehealth. This issue also contains original research evaluating the feasibility of providing pediatric dysphagia treatment via telepractice, a clinical report of student learning outcomes associated with an innovative experiential learning assignment involving (international teleconsultation in a Master of Science in Occupational Therapy (MSOT curriculum, a book review, and announcements from the American Telemedicine Association.

  5. Editors' Note

    Directory of Open Access Journals (Sweden)

    Ellen R. Cohn

    2015-11-01

    Full Text Available The Fall 2015 issue of the International Journal of Telerehabilitation (IJT presents the original work of three distinguished and innovative interdisciplinary teams.  Interdisciplinarity is also a hallmark of the IJT editorial staff, reviewers, and publishing team.The first article is a product of engineers with expertise in computing science (LoPresti and Simpson and a medical speech-language pathologist (Jinks who practices in the area of assistive technology. These authors reported upon the degree to which consumers are satisfied with the provision of telerehabilitation services for augmentative and alternative communication or alternative computer accessibility.A second article, by Proffitt, (occupational therapist and Lange, (a physiotherapist with expertise in the use of interactive video games and virtual reality technologies demonstrated the feasibility of employing a 6-week, game-based, in-home telerehabilitation exercise program using the Microsoft Kinect® for individuals with chronic stroke.Finally, the third article co-authored by Watzlaf (health information management, with degrees in public health and epidemiology, DeAlmeida (health information systems, with a degree in cell and molecular biology, Zhou (with degrees in computer science and physics, and expertise in mathematical modeling on health related topics, information integration, and comparative genomics, and Hartman (a reference librarian with a degree in chemistry, who collaborates with faculty in the health sciences and serves as a liaison to a school of health and rehabilitation sciences describes a protocol to conduct systematic reviews of research in telerehabilitation, with the aim that IJT readers can ultimately apply this protocol to identify best practices in telerehabilitation.

  6. Editors' note

    Science.gov (United States)

    Denker, Carsten; Feller, Alex; Schmidt, Wolfgang; von der Lühe, Oskar

    2012-11-01

    This topical issue of Astronomische Nachrichten/Astronomical Notes is a collection of reference articles covering the GREGOR solar telescope, its science capabilities, its subsystems, and its dedicated suite of instruments for high-resolution observations of the Sun. Because ground-based telescopes have life spans of several decades, it is only natural that they continuously reinvent themselves. Literally, the GREGOR telescope builds on the foundations of the venerable Gregory-Coudé Telescope (GCT) at Observatorio del Teide, Tenerife, Spain. Acknowledging the fact that new discoveries in observational solar physics are driven by larger apertures to collect more photons and to scrutinize the Sun in finer detail, the GCT was decommissioned and the building was made available to the GREGOR project.

  7. Editor's Introduction

    OpenAIRE

    Wiley, Jennifer

    2016-01-01

    As noted in the last bibliography of Human Problem Solving compiled by Joachim Funke and reported in the Journal of Problem Solving in 2013, problem solving as a concept and as a research issue has been gaining more interest than ever before. Now in 2016, we can see that publications on the topic further increased to around 1,800 per year in both 2013 and 2014. The papers in this special issue come from two areas of problem solving research, mathematical and creative problem solving, which re...

  8. Editors' Introduction

    Directory of Open Access Journals (Sweden)

    Mathieu Marion

    2013-12-01

    Full Text Available The idea of interpreting quantifiers in terms of a game between two players was first suggested at the end of the 19th century by one of the inventors of quantification theory, C. S. Peirce, but it laid buried in his papers until it was discovered in the 1980s. His idea was independently discovered in the 1950s, when Leon Henkin suggested a game semantics for infinitary languages. Paul Lorenzen introduced his Dialogspiele at the same time, while his student Kuno Lorenz introduced the vocabulary of game theory that led to our modern conception of game semantics shortly after. The idea is to provide an explanation of the meaning of the logical connectives and quantifiers in terms of rules for non-collaborative, zero-sum games between two agents, one of whom argues for the validity of the claim against moves from the other, and to define truth in terms of the existence of a winning strategy for the defender.

  9. Editor's Preface

    DEFF Research Database (Denmark)

    Stewart, Jon Bartley

    2007-01-01

      This volume, the third in the series, contains the proceedings of the conference 'Law before Gratian' and covers a wide range of topics from individual and local studies to broader reflections on the status and function of law in medieval European societies before the scholastic legal 'revoluti...... to this volume are Maurizio Lupoi (Genova), Alic Rio (Oxford), Charles Radding (Michigan), Martin Brett (Cambridge), Bruce Brasington (West Texas A&M) and Dominique Bauer (Ghent)....

  10. Editor's Note

    Directory of Open Access Journals (Sweden)

    Francisco Mochón

    2018-03-01

    Full Text Available The International Journal of Interactive Multimedia and Artificial Intelligence - IJIMAI (ISSN 1989 - 1660 provides an interdisciplinary forum in which scientists and professionals can share their research results and report new advances on AI tools or tools that use AI with interactive multimedia techniques.

  11. Editor comments

    Science.gov (United States)

    Gouker, Pascale; Ferlet-Cavrois, Véronique; Pellish, Jonathan

    2013-06-01

    This June 2013 Special Issue of the IEEE TRANSACTIONS ON NUCLEAR SCIENCE commemorates the 50th Anniversary of the IEEE International Nuclear and Space Radiation Effects Conference (NSREC). At the NSREC, held annually in July, scientists and engineers from industry, academia, and government institutions present their latest research on radiation effects in materials, electronic devices, circuits, and systems. The conference is the primary forum for technical presentations in the area of radiation effects, with attendance from over 20 countries around the world. It is also an important venue for companies to present their latest products and where students, young graduates, and experienced professionals meet, share ideas, and plan new experiments. Indeed, NSREC has been at the heart of the radiation effects community for 50 years. This special issue consists of review articles summarizing the research that has been published over the past ten years on subjects of interest to this community. The range of topics covered attests to our diversified and rich background.

  12. Editor's Note

    African Journals Online (AJOL)

    Our policy requires us to produce two issues of the CJAS in a year, and for some ... Avorgbedor of the University of Ghana Music Department for their invaluable ... Trondheim, for translating the abstracts into French at no cost to the Journal.

  13. EDITOR'S CHOICE

    African Journals Online (AJOL)

    autism, perpetrated by Dr Andrew Wakefield and published in, and later ... Efficacy and effectiveness of an rVSV-vectored vaccine ... Lucretia Petersen* is a senior lecturer in audiology in the Division of Communication Sciences and Disorders.

  14. Editor's note

    African Journals Online (AJOL)

    security systems in some countries as a risk to further improvement. The report provides ... obesity are a cause for serious concern and mandate reflection ... been listed in the app stores (Apple® and Android) in the publisher's app called The ...

  15. Editors note

    Directory of Open Access Journals (Sweden)

    Yngve Nordkvelle

    2017-01-01

    Full Text Available Lifelong learning is a recurring theme in this journal. The present issue of Seminar.net has four contributions, covering a range from how elderly use ICT, how teachers and supervisors in higher education experience virtual learning environments, how producers of MOOC’s fail to observe quality frameworks, and last how “gamification” affects ideas about teaching and learning. They all bring vital arguments to the table about how digital environments cause changes in our lives, beginning with games for children and helping elderly to adjust to an increasingly digitized lifeworld in the other end of the life cycle. First, most of the technological innovations we are used to by now, was invented a long time ago – by persons who now are considered elderly. The ideologies supported around notions like “the digital natives” are exactly that, - ideologies. But even skilled and experienced elderly – and teachers in higher education are in dire need of keeping up with swift changes in technology and its use. I am very pleased that the articles we present here have a critical stance towards ideologies and are able to scrutinise the conditions for a democratic and factual base for education.The opening article in this issue, “Older active users of ICTs make sense of their engagement”by Magdalena Kania-Lundholm and Sandra Torres, who work at Uppsala University, Sweden enlightens us about how elderly people use digital media. Instead of seeing the elderly as a group of “digital immigrants”, this article focuses on elderly people who are active and skilled users of ICT. They are eager to share their skills and experiences and contribute to the wellbeing of other, not so eager users. The article contributes to the notion of “the digital spectrum” and furthers the very important discussion on the inequalities that using ICT continues to bring about.The second article is written by Chris O’Toole, of Lancaster University, and has the title “Networked e-Learning: The changing facilitator - learner relationship, a facilitators’ perspective; A Phenomenological Investigation”. The phenomenological case study deals with how the relationship between facilitator and student is changing. Networked e-Learning is the context and the research is undertaken at an Irish higher education institution.The author’s role as a highly experienced facilitator provides particular and specific insight into the guiding facilitator’s experiences during a time of institutional transition to Networked e-Learning.Gamification is a topic that has been declared as “up and coming” for a number of years. Marc Fabian Buck, of the Nord University, Norway, presents the article “Gamification of learning and teaching in schools – a critical stance”. He states that the aim of Gamification is to change learning for the better by making use of the motivating effects of (digital games and elements typical of games, like experience points, levelling, quests, rankings etc. His most contemporary example is of the “Summer of ‘16” and the apparent success of “Pokemon go”. He argues that gamified learning and teaching suspends the fundamental, subversive, and critical moments only schools can offer.The last article is provided by Ulf Olsson, of Stockholm University, Sweden: “Teachers’ Awareness of Guidelines for Quality Assurance when developing MOOCs”. His study focuses on higher education teachers’ awareness of quality issues in relation to Standards and Guidelines for Quality Assurance in the European Higher Education Area (ESG. Olsson conducted semi-structured interviews with 20 teachers at six Swedish HEIs while they developed open courses (MOOCs. The overall findings show that the teachers were not part of any transparent quality assurance system. Subsequently, he raises the question of the adequacy of a quality system for innovative activities.

  16. Editors Introduction

    OpenAIRE

    Howard Kunreuther; Paul R Kleindorfer; Ortwin Renn

    1996-01-01

    Summary of papersAs the above notes on the small group discussion highlight, a number of significant challenges face researchers, practitioners and policy makers in defining sustainable management and in designing a set of institutional arrangements which can work together to achieve implementable environmental and risk management solutions. The papers in this Special Issue address some of the problems posed in the small groups. They each offer a set of promising ideas for developing programs...

  17. Editor's Choice

    DEFF Research Database (Denmark)

    Foegh, P; Jensen, L P; Klitfod, L

    2017-01-01

    , and annually thereafter following the DVT. Successful outcome was defined as patent deep veins without reflux on Duplex ultrasound scanning (DUS). Data were collected prospectively as per protocol and analysed retrospectively. RESULTS: Median age was 27 years (range 14-74 years) and overall median lysis time...... was 56 h (range 22-146 h). A stent was placed in 106 limbs (52%). Six patients had major bleeding. The median follow-up was 5 years (range 1 month-14.3 years). The cumulative rate of patients with deep patent veins without reflux at 7 years was 79%. Multivariate Cox regression analyses showed...... that symptom duration >2 weeks (hazard ratio (HR) 2.78, 95% CI 1.14-6.73) and chronic post-thrombotic lesions (HR 19.3, 95% CI 7.29-51.2) were significantly associated with poorer outcome, while the pulse-spray technique (HR 0.15, 95% CI 0.05-0.48) was associated with better outcome. Age, gender, side, IVC...

  18. Editor's choice

    DEFF Research Database (Denmark)

    Larzon, T; Roos, H; Gruber, G

    2015-01-01

    OBJECTIVES: The aim was to investigate whether the fascia suture technique (FST) can reduce access closure time and procedural costs compared with the Prostar technique (Prostar) in patients undergoing endovascular aortic repair and to evaluate the short- and mid-term outcomes of both techniques....... METHODS: In this two center trial, 100 patients were randomized to access closure by either FST or Prostar between June 2006 and December 2009. The primary endpoint was access closure time. Secondary outcome measures included access related costs and evaluation of the short- and mid-term complications....... Evaluation was performed peri- and post-operatively, at discharge, at 30 days and at 6 months follow up. RESULTS: The median access closure time was 12.4 minutes for FST and 19.9 minutes for Prostar (p

  19. Editor's note

    African Journals Online (AJOL)

    remains uncontested”, and confirms: “However, the translation of this recommendation into successful practice continues to fall short”. Uncontested as the benefits ... Education and Training,1 is a revision of the Policy and procedures for measurement of research output of public higher education institutions (2003),2 and will ...

  20. From Editor

    OpenAIRE

    Ugur Demiray

    2007-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 8th year of TOJDE are appeared on your screen now as Volume 8, Number: 4. Ti is the last issue of the year 2007. As you volume ( Number 3 was the special issue of TOJDE on “Web 2.0 and Social Software in Distance Education” subject. I received many congrulation for this special issue from the subject expert and TOJDE readers. During 6 months I received more than 45 submissions. Some of them rejected by me for the reason t...

  1. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Readers, Welcome to the Volume 14 Number: 3 of TOJDE! In this issue, 17 articles of 28 authors from 9 different countries around the world have been published. These published articles are arrived to the TOJDE from, Greece, India, Iran, Malaysia, Pakistan, Thailand, Turkey and USA. The 1st article is arrived from Greece and written by Evangelia MANOUSOU, Tutor-Counselor and Antonis LIONARAKIS. Their article deals with a documented research in order to create a ped...

  2. Editor's note

    African Journals Online (AJOL)

    http://medpharm.tandfonline.com/toc/ojcn20/current. Our readers can therefore get a glimpse of the new look website which, hopefully, will be adopted as of the third 2016 issue of the SAJCN. The third annual Global Nutrition Report1 was released in June 2016. Part of its full title “Ending Malnutrition by 2030” brings hope ...

  3. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Reade Welcome to the Volume 14 Number: 4 of TOJDE! In this issue, 24 articles of 39 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from, Bengaldesh, Ethiopia, Greece, India, Indonesia, Iran, Malaysia, Pakistan, Romania, Russia, South Africa, Thailand, Turkey, UAE, USA and Zimbawbe The 1st article is arrived from Russia written by Alexander Aleksandrovich RYBANOV, His article titled as “EDUCATEE...

  4. Editor's Note

    Directory of Open Access Journals (Sweden)

    Ellen R. Cohn

    2012-06-01

    Full Text Available The current issue of the International Journal of Telerehabilitation (IJT contains original research evaluating the efficacy of telerehabilitation; an evaluation of a telerehabilitation system for community based research; and work that examines users’ perceptions of the privacy and security of the three top used consumer-based, free Voice and video over the Internet Protocol (VoIP software systems (e.g., Skype  and others used by health care providers to deliver therapeutic services via telerehabilitation. Two Brief Communications authored by speech-language pathologists present the possibilities for significant telehealth related cost-savings when telepractice is implemented in clinical practice.  Finally, this issue presents a report generated by a working group within the American Telemedicine Association’s Telerehabilitation Special Interest Group, and announcements from the American Telemedicine Association and the International Society for Augmentative and Alternative Communication (ISAAC.

  5. Editor's Note

    Directory of Open Access Journals (Sweden)

    Daniel Shanahan

    2017-01-01

    Full Text Available THIS issue marks the second of two special issues focusing on corpus approaches to musicological and music-theoretical research. What began as a simple call for papers turned into a fairly ambitious project, and I couldn't be more pleased with the result. The range and depth of the articles in these two issues demonstrates the level of scholarly work being conducted in this growing area of research. In this issue, Derek Strykowski's article on text-painting in Marenzio's madrigals provides a model for how one might search address the often difficult-to-test notion of text-painting, and Craig Sapp's commentary is a nice supplemental discussion of the topic, offering avenues of future research. Fernando Benadon's analysis of roughly 30,000 onset times in Afro-Cuban drumming focuses on the notion of "near onsets" and "onset clusters", and Peter Marten's commentary argues that, while this might be difficult to perceive, the methodology demonstrates an excellent model for future research. Steven Cannon's analysis of the form of 19th-century symphonies is enlightening, and provides a nice empirical backing to much of the extant literature on the repertoire, and Ben Duane's response provides a nice commentary on future directions and possible methodological improvements. Caitlyn Trevor and David Huron's article on the usage of open strings in nominally sad music deftly bridges emotion research and instrumental affordances, and Daniel Müllensiefen's commentary praises the methodology, laments the negative results, and issues a call for more negative results to be published. Perhaps the most unique aspect of Empirical Musicology Review is the "open peer review" format it pioneered a decade ago. This issue contains a number of commentaries —and responses to commentaries— that fit within that vision. Nat Condit-Schultz and Mitch Ohriner take two fascinating but different approaches to the notion of "flow" in hip-hop, and provide insightful commentaries for one another, while Jacob Gran's commentary offers a nice overview of both approaches. Joseph Daniele lays out a framework for using nPVI for historical research, and Leigh VanHandel's alternative reading of the data is fascinating. Daniele's response is thoughtful and thorough, and the exchange really illustrates the scholarly back-and-forth that this journal was meant to foster.

  6. Editor's note

    Directory of Open Access Journals (Sweden)

    Editor’s Note

    2006-11-01

    Full Text Available A “Thousand Words” is a new essay feature of the CODATA Data Science Journal. Each of these essays is intended to paint a picture of a thousand words of a subject important to data scientists. It is opinion – not research, but nevertheless of interest and importance to understanding the fundamental role data science plays in today’s scientific research and development

  7. Editors page

    Directory of Open Access Journals (Sweden)

    Margarita Barretto

    2007-09-01

    Full Text Available O poeta espanhol Antonio machado disse "caminante, ho hay camino, se hace el camino al andar". É andando que estamos fazendo o caminho da Turismologia no Brasil, e é com muito orgulho que, como parte deste andar entregamos ao público o primeiro número da Revista Brasileira de Pesquisa em Turismo, iniciativa da ANPTUR - Associação Nacional de Pesquisa e Pós-Graduação em Turismo. Esta revista pretende ser uma contribuição significativa para o processo de cientifização crescente dos estudos de Turismo que se observa no país e no mundo, abrindo espaço para difundir os resultados das pesquisas realizadas a partir dos olhares multidisciplinares na expectativa de chegar à desejada transdisciplinaridade que o Turismo, enquanto fenômeno social total que é, demanda para sua compreensão. Muitas são as afirmações realizadas a respeito do Turismo e seus efeitos na sociedade, mas poucas são as pesquisas que comprovam os mesmos. Os economistas afirmam que o Turismo gera muitos empregos e que tem um grande efeito multiplicador. Precisamos, no entanto, pesquisar quais são os tipos de empregos gerados e qual o alcance deste efeito multiplicador, quais as implicações da evasão de impostos e qual a relação desta última com a história social dos países. Também há poucas pesquisas sobre os efeitos do Turismo nas formas tradicionais de produção. Do ponto de vista sociológico e antropológico, é preciso aprofundar em pesquisas incipinetes já realizadas sobre quais efeitos nas famílias tradicionais do ingresso no mercado de trabalho das mulheres. É preciso relacionar Turismo com questões de gênero e identidade. Também é necessário estudar a influência com questões como etnia e nacionalidade na empregabilidade no setor, assim como a relação entre Migralção e Turismo e a cada vez mais frequente transformação de imigrantes em turistas e vice versa. Muitos têm sido os estudos realizados no passado sobre os processos de aculturação supostamente provocados pelo Turismo. É preciso, no entanto, verificar a relação da aculturação coma história social e a auto-estima dos povos. Na década de 1980 os defensores da chamada plataforma da conciliação propuseram novas formas de Turismo, que permitissem a convivência dos visitantes com os visitados. No entanto, é preciso ainda avaliart qual a influência dos preconceitos e estereótipos no relacionamento destes, assim como qual o limite da possibilidade de conviv~encia antes que a mes ma se transforme em invasão de privacidade. É necessário estar atento às implicações na área da saúde de novas formas de turismo rural, por exemplo. E, fundamentalmente, verificar qual o limite aceitável da turistificação de espaços e costumes. Sabemos que a resposta a estas questões não é fácil de se obter, porque é muito difícil isolar o turismo de outros fenômenos sociais coadjunvantes que podem ou não ter com ele uma relação causal. Apesar das dificuldades inerentes à pesquisa na área de Turismo temos certeza de que estamos trilhando o caminho, com uma comunidade científica que se esforça por investigar seriamente este objeto, fascinante por sua complexidade e diversidade. O formato eletrônico da Revista Brasileira de Pesquisa em Turismo, conjugado comn a gratuidade, permitirá o acesso livre e irrestrito por parte de todos os interessados, em qualquer parte do mundo, propiciando assim a difusão ampla do conhecimento asem barreiras físicas ou econômicas, o que é missão de uma associação de classe. No primeiro número, apresentamos artigos versando sobre educação, ensino, souvenirs, memória coletiva e museus. O artigo de Ari da Silva Fonseca FIlho apresenta um panorama da educação para o Turismo no ensino básico, concluindo que os programas desenvolvidos formam. ao mesmo tempo, bons turistas e bons anfitriões. A análise dos souvenirs realizada por Bianca Freire-Medeiros e Celso castro permite ver como estes compôem a imagem turística do Rio de Janeiro, observando que muitas vrezes aquilo que para os cariocas pode ser de mau gosto, é comprado entusiasticamente pelos turistas. Ceres Karam Brum analisa o processo de construção da memória coletiva da região das Missões, onde se desenvolvem projetos de turismo religioso, concluindo que há uma relação dialética entre a proposta turística oficial e a postura da população, mas que, no entanto, permite um turismo edificante. Márcia M. Cappellano dos Santos argumenta que, paradoixalmente, o incremento dos estudos científicos em Turismo não tem diso acompanhado de inovações nas propostas didático-pedagógicas. para avançar neste campo, apresenta o resultado de uma experiência bem sucedida para formar professores de Turismo. Como representante do exterior, Tânia Siedlecki Huerta descreve as mudanças acontecidas nos juseus para atender a demanda turística, incorporando novos paradigmas comunicacionais e os conceitos de dialogismo, alteridade e multiculturalidade. Este número apresenta também a resenha de um polêmico livro de Helton Ouriques e a crônica do II Simpósio Internacional de Pesquisa realizado em Misiones, Argentina. Margarita Barreto Sênia Regina Bastos Editoras

  8. Editors' Note

    Directory of Open Access Journals (Sweden)

    Ellen R. Cohn

    2015-01-01

    Full Text Available The Fall 2014 issue of the International Journal of Telerehabilitation (IJT contains original research that evaluates the role of teletherapy and online language exercises in the treatment of chronic aphasia; investigates whether improvements are maintained after in-home pulmonary telerehabilitation for patients with chronic obstructive pulmonary disease; and studies the use of in-home telerehabilitation for proximal humerus fractures. Within the context of two case studies, an author evaluated three service delivery models (direct, hybrid, and telepractice for stuttering intervention. The results of a preliminary qualitative investigation are presented for telepractice in rural schools in Australia. And, schemas are offered for privacy and security analyses for store and forward applications in physical and occupational therapy. The Fall 2014 issue also contains a book review, and announcements from the American Telemedicine Association and the Mid-Atlantic Telehealth Resource Center.

  9. Editor's Notes

    African Journals Online (AJOL)

    ... eye health of the public. We also call for editorials on contemporary issues of concern in Optometry in Nigeria. Our overall objec ve is to make the journal of. Nigerian Optometric Associa on a high impact factor journal in Nigeria and globally. Journal of the Nigerian Optometric Association. Dr. Bernadine Nsa Ekpenyong.

  10. FloorspaceJS - A New, Open Source, Web-Based Geometry Editor for Building Energy Modeling (BEM): Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Macumber, Daniel L [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Horowitz, Scott G [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Schott, Marjorie [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Nolan, Katie [Devetry; Schiller, Brian [Devetry

    2018-03-19

    Across most industries, desktop applications are being rapidly migrated to web applications for a variety of reasons. Web applications are inherently cross platform, mobile, and easier to distribute than desktop applications. Fueling this trend are a wide range of free, open source libraries and frameworks that make it incredibly easy to develop powerful web applications. The building energy modeling community is just beginning to pick up on these larger trends, with a small but growing number of building energy modeling applications starting on or moving to the web. This paper presents a new, open source, web based geometry editor for Building Energy Modeling (BEM). The editor is written completely in JavaScript and runs in a modern web browser. The editor works on a custom JSON file format and is designed to be integrated into a variety of web and desktop applications. The web based editor is available to use as a standalone web application at: https://nrel.github.io/openstudio-geometry-editor/. An example integration is demonstrated with the OpenStudio desktop application. Finally, the editor can be easily integrated with a wide range of possible building energy modeling web applications.

  11. Editors are editors, not oracles

    Science.gov (United States)

    Schimel, Dave; Strong, Donald R.; Ellison, Aaron M.; Peters, Debra P. C.; Silver, Sue; Johnson, Edward A.; Belnap, Jayne; Classen, Aimee T.; Essington, Timothy E.; Finley, Andrew O.; Inouye, Brian D.; Stanley, Emily H.

    2014-01-01

    Farji-Brener and Kitzberger (2014; hereafter FBK) resurrect the issues of Farji-Brener (2007) concerning manuscripts that are submitted to journals but that are not sent out for peer review: a process we call “reject following editorial review” (RFER). We thank FBK for reviving discussion about this important topic as new challenges, including new publication outlets, peer-review models, and an increasingly complex and voluminous scientific literature, are emerging across the publication landscape. While we disagree with FBK's perspective and conclusions, we recognize that this discussion can help to improve editorial and publication processes, and we welcome the opportunity to inform the ecological community about the current status of editorial practice at ESA journals.

  12. Multistate Model Builder (MSMB): a flexible editor for compact biochemical models.

    Science.gov (United States)

    Palmisano, Alida; Hoops, Stefan; Watson, Layne T; Jones, Thomas C; Tyson, John J; Shaffer, Clifford A

    2014-04-04

    Building models of molecular regulatory networks is challenging not just because of the intrinsic difficulty of describing complex biological processes. Writing a model is a creative effort that calls for more flexibility and interactive support than offered by many of today's biochemical model editors. Our model editor MSMB - Multistate Model Builder - supports multistate models created using different modeling styles. MSMB provides two separate advances on existing network model editors. (1) A simple but powerful syntax is used to describe multistate species. This reduces the number of reactions needed to represent certain molecular systems, thereby reducing the complexity of model creation. (2) Extensive feedback is given during all stages of the model creation process on the existing state of the model. Users may activate error notifications of varying stringency on the fly, and use these messages as a guide toward a consistent, syntactically correct model. MSMB default values and behavior during model manipulation (e.g., when renaming or deleting an element) can be adapted to suit the modeler, thus supporting creativity rather than interfering with it. MSMB's internal model representation allows saving a model with errors and inconsistencies (e.g., an undefined function argument; a syntactically malformed reaction). A consistent model can be exported to SBML or COPASI formats. We show the effectiveness of MSMB's multistate syntax through models of the cell cycle and mRNA transcription. Using multistate reactions reduces the number of reactions need to encode many biochemical network models. This reduces the cognitive load for a given model, thereby making it easier for modelers to build more complex models. The many interactive editing support features provided by MSMB make it easier for modelers to create syntactically valid models, thus speeding model creation. Complete information and the installation package can be found at http

  13. Funding source and conflict of interest disclosures by authors and editors in gastroenterology specialty journals revisited.

    Science.gov (United States)

    Qureshi, J; Sud, A; Vakil, N

    2012-03-01

    A survey of journals published in the field of Gastroenterology conducted 5 years ago showed marked variability in reporting of conflicts of interest or funding sources in these journals. To re-examine reporting of conflicts of interest and funding sources for original articles and editorials in Gastroenterology and Hepatology journals. We evaluated all original articles and editorials in 15 leading journals (determined by impact factor-Thomson Reuter Science Citation Index) devoted to Gastroenterology and Hepatology for disclosures of conflicts and for editor's self disclosures. We examined each journal's editorial policy by contacting the journal directly if the information was not revealed on the Web site or print versions of the journal. Of the 1574 articles evaluated, a total of 1207 (77%) reported the presence or absence of a potential conflict of interest and 1047 (67%) reported the presence or absence of funding sources. A total of 3 of the 15 (20%) journals (American Journal of Gastroenterology, Gastroenterology, and Alimentary Pharmacology and Therapeutics reported the presence or absence of funding sources in all their published original articles. Only 5 of 15 (33%) journals (Gut, Gastrointestinal Endoscopy, American Journal of Gastroenterology, Neurogastroenterology & Motility and Alimentary Pharmacology and Therapeutics) publicly disclosed the conflicts of interest of the editors. (i) Funding sources and conflicts of interest are still reported variably in the GI literature. (ii) Editorials and review articles are influential, but have poor reporting of conflicts of interest. (iii) Editors of many journals still do not report their conflicts of interest. © 2012 Blackwell Publishing Ltd.

  14. New Editor-in-Chief for Journal of Physics A: Mathematical and Theoretical

    Science.gov (United States)

    Gillan, Rebecca

    2014-04-01

    We are delighted to announce that Professor Martin Evans of University of Edinburgh has been appointed as the new Editor-in-Chief of Journal of Physics A: Mathematical and Theoretical. Martin Evans has been Editor of the Statistical Physics section of the journal since 2009. Prior to this, he served as a Board Member for the journal. His areas of research include statistical mechanics of nonequilibrium systems, phase transitions and scaling regimes in nonequilibrium statistical physics, glassy dynamics, phase transitions and ordering in driven diffusive systems, mass transport models, condensation models, zero range processes and exclusion processes. We very much look forward to working with Martin to continue to improve the journal's quality and interest to the readership. We would like to thank our outgoing Editor-in-Chief, Professor Murray Batchelor. Murray has worked hard and provided excellent guidance in improving the quality of the journal and the service that the journal provides to authors, referees and readers. During the last five years, we have raised the quality threshold for acceptance in the journal and currently reject over 70% of submissions. As a result, papers published in Journal of Physics A: Mathematical and Theoretical are amongst the best in the field. We have also maintained and improved on our excellent receipt-to-first-decision times, which now average under 40 days for papers. With the help of Martin Evans and our distinguished Editorial Board, we will be working to further improve the quality of the journal whilst continuing to offer excellent services to our readers, authors and referees. We hope that you benefit from reading the journal. If you have any comments or questions, please do not hesitate to contact us at jphysa@iop.org. Rebecca Gillan Publisher

  15. Joaquín García Monge: escritor, editor, pensador y humanista

    OpenAIRE

    Arias, Jaime Mora

    2014-01-01

    Joaquín Monge nació el 20 de enero de 1881 y falleció el 31 de octubre de 1958. Realizó sus estudios primarios en la escuela de su ciudad natal Desamparados, los secundarios en el Internado del Liceo de Costa Rica y los superiores en el Instituto Pedagógico de la Facultad de Filosofía y Humanidades de la Universidad de Chile. Fue escritor de cuentos y novelas, así como de numerosos artículos y cartas; editor por treinta y nueve años ininterrumpidos de la revista de alcance y cobertura contine...

  16. Locking Editor A Utility For Protecting Software Exercises In The Computer Laboratory Of AMA University

    Directory of Open Access Journals (Sweden)

    Paul M. Grafilon

    2017-07-01

    Full Text Available The student of AMA University persistence in computing which has the keys to providing their talent needed to fill the computer laboratory in the computing professions. A range of factors can affect a students decision to remain in a computing major or change to another major if ever they feel that computing education is difficult. This has to describe the activities in computer laboratory specifically exercises machine problems and computing case studies interacting different application programs as the basis of their skills and knowledge in programming capability. The nature of those activities addresses by using of IDE as open source in all programming applications which may result of specific intervention such as using the editor to create a source file the code blocks comments and program statements are entered and the file saved. In case there are no corrective actions taken as the editor does not know this is supposed to be a source file as opposed to notes for class. If working in a position-dependent language like Java the developer would have to be very careful about indenting. The file has to be saved with the correct file extension and in a directory where the compiler can find it. Each source file has to be compiled separately if the program has a few source files they all have to be named separately in the compiler. When invoking the compiler it has to be directed to look in the correct directory for the source files and where the output files should be stored. If there is an error in the source file the compiler will output messages and fail to complete. For any errors the developer goes back and edits the source file working from line numbers and compiler messages to fix the problems and these steps continue until all the source files compile without errors. When linking each object file is specified as being part of the build. Again the locations for the object files and executable are given. There may be errors at this point

  17. RadConEd: A Graphical Data Editor for the Radiological Consequences Model, RadCon

    International Nuclear Information System (INIS)

    Crawford, J.; Domel, R.U.

    2000-05-01

    This document describes the application, RadConEd, which has been designed and implemented to enable users of the RadCon system to update these parameter files. The RadCon system is written in the Java programming language, and as such provides portability across computer platforms. The software described in this report was developed in line with the portability requirements of RadCon, thus providing a uniform user interface across computer platforms and bypassing the need of using system editors. In addition a number of data integrity measures were implemented

  18. MULTIMEDIA EDITOR OF VIRTUAL PHYSICAL LABORATORY IN DISTANCE LEARNING SYSTEM «KHERSON VIRTUAL UNIVERSITY»

    OpenAIRE

    Kravtsov H.; Baiev A.; Lemeshchuk O.; Orlov V.

    2017-01-01

    The questions of modeling the structure of the objects of the system, the design of software modules and technologies for creating the editor of a virtual laboratory are considered. The relevance of the study is due to the lack in existing distance learning systems of support for the creation and use of virtual laboratory work on disciplines of the natural-science profile. The subject of the study is a software module for creating and using virtual laboratory work in a distance learning syste...

  19. Archaeology in Latin America, by Gustavo G. Politis and Benjamin Alberti, editors, 1999, Routledge, London

    Directory of Open Access Journals (Sweden)

    David L. Browman

    2001-11-01

    Full Text Available The two editors argue in their preface to the volume that the particular sociopolitical context of Latin America has led to a regionalism not seen in North America or Europe, resulting in a unique variety of archaeology. They particularly conceive "Latin American archaeology" in this case to he only that archaeology done by individuals who are citizens of the countries of the region, and they ex­clude from consideration as being considered "Latin American archaeology" the work of foreign scholars such as North Americans and Europeans who do research in the region.

  20. Topographic Maps on the Territory of Croatia Editor: Stanislav Frangeš

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2012-06-01

    Full Text Available Promotion of the monograph Topographic Maps on the Territory of Croatiawas organized by the Croatian Cartographic Society and held at the Croatian State Archive in Zagreb on April 18, 2012. At the beginning of the promotion, guests were welcomed by Dr. Stjepan Ćosić, Director of the Croatian State Archive. The monograph was then represented by Prof. Dr. Stanislav Frangeš, the book's editor, Prof. Dr. Miljenko Lapaine, the book's reviewer, and MSc Ivan Landek, one of the book's authors.

  1. Advanced software development workstation. Engineering scripting language graphical editor: DRAFT design document

    Science.gov (United States)

    1991-01-01

    The Engineering Scripting Language (ESL) is a language designed to allow nonprogramming users to write Higher Order Language (HOL) programs by drawing directed graphs to represent the program and having the system generate the corresponding program in HOL. The ESL system supports user generation of HOL programs through the manipulation of directed graphs. The components of this graphs (nodes, ports, and connectors) are objects each of which has its own properties and property values. The purpose of the ESL graphical editor is to allow the user to create or edit graph objects which represent programs.

  2. News from the editors of Fluids and Barriers of the CNS.

    Science.gov (United States)

    Drewes, Lester R; Jones, Hazel C; Keep, Richard F

    2014-01-01

    This editorial announces a new affiliation between Fluids and Barriers of the CNS (FBCNS) and the International Brain Barriers Society (IBBS) with mutual benefits to the journal and to society members. This is a natural progression from the appointment of two new Co-Editors in Chief: Professor Lester Drewes and Professor Richard Keep in 2013. FBCNS provides a unique and specialist platform for the publication of research in the expanding fields of brain barriers and brain fluid systems in both health and disease.

  3. vi and Vim Editors Pocket Reference Support for every text editing task

    CERN Document Server

    Robbins, Arnold

    2011-01-01

    Many Unix, Linux, and Mac OS X geeks enjoy using the powerful, platform-agnostic text editors vi and Vim, but there are far too many commands for anyone to remember. Author Arnold Robbins has chosen the most valuable commands for vi, Vim, and vi's main clones-vile, elvis, and nvi-and packed them into this easy-to-browse pocket reference. You'll find commands for all kinds of editing tasks, such as programming, modifying system files, and writing and marking up articles. This second edition includes: Command-line optionsvi commands and set optionsInput mode shortcutsSubstitution and regular e

  4. Improving the quality of papers submitted to dental journals: Transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Cape Town on Wednesday, 25 June 2014.

    Science.gov (United States)

    Eaton, Kenneth A; Giannobile, William V; Sourgen, Deborah L; Balaji, S M; Honkala, Eino; Lynch, Christopher D

    2015-08-01

    This satellite symposium was the fourth in a series for editors, publishers, reviewers and all those with an interest in scientific publishing. It was held on Wednesday 25th June 2014 at the IADR International meeting in Cape Town, South Africa. The symposium attracted more than 180 attendees. This symposium placed an emphasis on how the quality of papers submitted to dental journals could be improved. The panel included representation from editors, researchers and publishers from North America, India and the Gulf States. The symposium identified a number of challenges for editors and publishers, including the poor quality of many papers submitted to dental and other scientific journals, plagiarism, attempted duplicate publication and sometimes fraudulent results. Where possible speakers are identified by name. A subsequent symposium was held during the IADR meeting in Boston on March 11th 2015. Involvement open to editors, associate editors, publishers and others with an interest in scientific publishing. Copyright © 2015. Published by Elsevier Ltd.. All rights reserved.

  5. Les vélins du Muséum national d’histoire naturelle : une collection mise en lumière

    OpenAIRE

    Cardinal, Catherine

    2018-01-01

    Une exposition unique au Cabinet d’histoire du Jardin des plantes Très rarement, le public a pu voir la collection d’images de fleurs, de plantes, d’oiseaux et de mammifères, déposée à la bibliothèque centrale du Musée national d’histoire naturelle. La fragilité des peintures sur vélin au contact de l’air humide et de la lumière explique les précautions prises à leur égard. L’exposition d’environ cent cinquante pièces au sein du Cabinet d’histoire, d’octobre 2016 à janvier 2017, a donc consti...

  6. Efeito e modo de ação das bacteriocinas produzidas por Lactococcus lactis subsp. lactis ITAL 383, ATCC 11454 e CNRZ 150 contra Listeria innocua LIN 11 Effect and mode of action of the bacterioncin produced by Lactococcus. lactis subsp. lactis ITAL 383, ATCC 11454 e CNRZ 150 against Listeria innocua LIN 11

    Directory of Open Access Journals (Sweden)

    Izildinha MORENO

    1999-01-01

    Full Text Available O efeito e o modo de ação das bacteriocinas produzidas por L. lactis subsp. lactis ITAL 383 e CNRZ 150 são similares à nisina de L. lactis subsp. lactis ATCC 11454. Estas bacteriocinas apresentaram um modo de ação bactericida, causando a lise de células de L. innocua LIN 11, associada ao decréscimo da absorbância e da viabilidade celular. O efeito letal foi maior para células em fase exponencial comparativamente à fase estacionária de crescimento. A adsorção dessas bacteriocinas às células de L. innocua LIN 11 foi muito rápida e influenciada pelo pH do meio de suspensão; adsorção máxima foi verificada a pH 6,0 e logo após o contato inicial. Perda completa de adsorção ocorreu em pH 2,0.The effect and mode of action of the bacteriocin produced by L. lactis subsp. lactis ITAL 383 and CNRZ 150 are similar to the nisin produced by L. lactis subsp. lactis ATCC 11454. It was clearly bactericidal, and caused lysis of a strain of L. innocua LIN 11 detected by the decrease of absorbance values and the cell viability. Their lethal effect was considerably higher during the logarithmic growth when compared to the stationary phase. Adsorption developed rapidly and was influenced by the pH value of the suspension medium. Maximum adsorption was observed at pH 6,0 and immediately after initial contact and loss at pH 2,0.

  7. Formation of positive cluster ions Li(n) Br (n = 2-7) and ionization energies studied by thermal ionization mass spectrometry.

    Science.gov (United States)

    Veličković, S R; Đustebek, J B; Veljković, F M; Veljković, M V

    2012-05-01

    Clusters of the type Li(n)X (X = halides) can be considered as potential building blocks of cluster-assembly materials. In this work, Li(n)Br (n = 2-7) clusters were obtained by a thermal ionization source of modified design and selected by a magnetic sector mass spectrometer. Positive ions of the Li(n)Br (n = 4-7) cluster were detected for the first time. The order of ion intensities was Li(2)Br(+) > Li(4)Br(+) > Li(5)Br(+) > Li(6)Br(+) > Li(3)Br(+). The ionization energies (IEs) were measured and found to be 3.95 ± 0.20 eV for Li(2)Br, 3.92 ± 0.20 eV for Li(3)Br, 3.93 ± 0.20 eV for Li(4)Br, 4.08 ± 0.20 eV for Li(5)Br, 4.14 ± 0.20 eV for Li(6)Br and 4.19 ± 0.20 eV for Li(7)Br. All of these clusters have a much lower ionization potential than that of the lithium atom, so they belong to the superalkali class. The IEs of Li(n)Br (n = 2-4) are slightly lower than those in the corresponding small Li(n) or Li(n)H clusters, whereas the IEs of Li(n)Br are very similar to those of Li(n) or Li(n)H for n = 5 and 6. The thermal ionization source of modified design is an important means for simultaneously obtaining and measuring the IEs of Li(n)Br (n = 2-7) clusters (because their ions are hermodynamically stable with respect to the loss of lithium atoms in the gas phase) and increasingly contributes toward the development of clusters for practical applications. Copyright © 2012 John Wiley & Sons, Ltd.

  8. Quando "falha a fala" e "fala a bala": lingua(gem e violência em Cidade de Deus, de Paulo Lins

    Directory of Open Access Journals (Sweden)

    Rita Gabrielli Pereira

    2018-04-01

    Full Text Available Cidade de Deus traz em si a história da construção do conjunto habitacional, cujo nome intitula o romance, e de sua transformação em uma das favelas mais violentas do Rio de Janeiro, por meio do entrecruzamento das histórias de Cabeleira, Bené, Zé Pequeno e Busca-Pé. Concebendo o romance, nos atos da escrita e da leitura, como uma enunciação (BENVENISTE, 1989a; 1989b; 1995a; 1995b entre autor e leitor, constituída por outras enunciações — entre narrador e narratário e entre personagens — a partir do "ato ficcional" (ISER, 2002 do autor, vamos nos guiar por essa tessitura de/entre histórias para rastrear o modo como Lins relaciona linguagem e violência. Palavras-chave: Lingua(gem, Subjetividade, Violência ______________________________ Cidade de Deus tells the history of the construction of the housing complex that entitles the novel and its transformation process into one of the most violent slums of Rio de Janeiro. By treating the novel as an enunciation (BENVENISTE, 1989a; 1989b; 1995a; 1995b between author and reader, which is made of other enunciations − between narrator and narratee and between characters −, based on the author´s “fictional act”(ISER, 2002, we intend to analyze the way how Lins relates language and violence. Keywords: Language, Subjectivity, Violence.

  9. Mentoring for text editors: Fit for purpose in the era of freelancing, more so than alternative development strategies

    Directory of Open Access Journals (Sweden)

    John Linnegar

    2015-12-01

    Full Text Available In this article, the supportive role that mentoring relationships currently do and should play in the development and careers of text editors is described against the background of the particular circumstances of these service providers in a sector experiencing great organisational and technological changes. This is a group that is much neglected in the literature on mentoring. Since the mentoring of text editors is distinct from other forms of mentoring in a number of key respects, this article draws together what the literature has to say about both conventional and online or distance mentoring as performed in a range of contexts. I consider the application of Knowles’ (1970, 1984 adult learning theory and Bandura’s (1977 self-efficacy mechanisms to be important potential contributors to the success of mentorships, in particular those involving adult text editors. The article also critically analyses how mentoring for text editors can be distinguished from alternative development strategies such as coaching, training, teaching and counselling. It shows that mentoring is fundamentally different from these strategies according to ten criteria, and is better suited to text editors’ need for professional development as a form of lifelong adult e-learning. The lack of any form of assessment of mentees, in particular, is regarded as a weakness of the currently available mentorship programmes aiming to professionalise adult text editors through a process of lifelong learning.

  10. Conflict and Computation on Wikipedia: A Finite-State Machine Analysis of Editor Interactions

    Directory of Open Access Journals (Sweden)

    Simon DeDeo

    2016-07-01

    Full Text Available What is the boundary between a vigorous argument and a breakdown of relations? What drives a group of individuals across it? Taking Wikipedia as a test case, we use a hidden Markov model to approximate the computational structure and social grammar of more than a decade of cooperation and conflict among its editors. Across a wide range of pages, we discover a bursty war/peace structure where the systems can become trapped, sometimes for months, in a computational subspace associated with significantly higher levels of conflict-tracking “revert” actions. Distinct patterns of behavior characterize the lower-conflict subspace, including tit-for-tat reversion. While a fraction of the transitions between these subspaces are associated with top-down actions taken by administrators, the effects are weak. Surprisingly, we find no statistical signal that transitions are associated with the appearance of particularly anti-social users, and only weak association with significant news events outside the system. These findings are consistent with transitions being driven by decentralized processes with no clear locus of control. Models of belief revision in the presence of a common resource for information-sharing predict the existence of two distinct phases: a disordered high-conflict phase, and a frozen phase with spontaneously-broken symmetry. The bistability we observe empirically may be a consequence of editor turn-over, which drives the system to a critical point between them.

  11. Semi-automated XML markup of biosystematic legacy literature with the GoldenGATE editor.

    Science.gov (United States)

    Sautter, Guido; Böhm, Klemens; Agosti, Donat

    2007-01-01

    Today, digitization of legacy literature is a big issue. This also applies to the domain of biosystematics, where this process has just started. Digitized biosystematics literature requires a very precise and fine grained markup in order to be useful for detailed search, data linkage and mining. However, manual markup on sentence level and below is cumbersome and time consuming. In this paper, we present and evaluate the GoldenGATE editor, which is designed for the special needs of marking up OCR output with XML. It is built in order to support the user in this process as far as possible: Its functionality ranges from easy, intuitive tagging through markup conversion to dynamic binding of configurable plug-ins provided by third parties. Our evaluation shows that marking up an OCR document using GoldenGATE is three to four times faster than with an off-the-shelf XML editor like XML-Spy. Using domain-specific NLP-based plug-ins, these numbers are even higher.

  12. xLPR Sim Editor 1.0 User's Guide

    Energy Technology Data Exchange (ETDEWEB)

    Mariner, Paul

    2017-03-01

    The United States Nuclear Regulatory Commission in cooperation with the Electric Power Research Institute contracted Sandia National Laboratories to develop the framework of a probabilistic fracture mechanics assessment code called xLPR ( Extremely Low Probability of Rupture) Version 2.0 . The purpose of xLPR is to evaluate degradation mechanisms in piping systems at nuclear power plants and to predict the probability of rupture. This report is a user's guide for xLPR Sim Editor 1.0 , a graphical user interface for creating and editing the xLPR Version 2.0 input file and for creating, editing, and using the xLPR Version 2.0 database files . The xLPR Sim Editor, provides a user - friendly way for users to change simulation options and input values, s elect input datasets from xLPR data bases, identify inputs needed for a simulation, and create and modify an input file for xLPR.

  13. Meeting the Editors at the 9th Iberoamerican Academy of Management Conference

    Directory of Open Access Journals (Sweden)

    Fernando Antonio Ribeiro Serra

    2016-06-01

    Full Text Available The following Editorial Comment presents a summary of the main ideas and suggestions presented at the “Meeting with the Editors” at the 9th Iberoamerican Academy of Management (IAM Conference, in Santiago (Chile. The meeting was conducted by three editors: Jonathan Doh from the Journal of World Business, Martin Larraza from Management Research and Herman Aguinis, President of the Iberoamerican Academy of Management and former editor of Organizational Research Methods. The conference took place from 3rd to 5th December 2015, and was hosted by Universidad Del Desarrollo. This editorial does not change the focus of the previous recent editorial comments of the Iberoamerican Journal of Strategic Management (IJSM. Its purpose of helping researchers and students in their quest to conduct quality research and publish it remains unchanged. These specific editorial comments are grouped in the menu section of the IJSM website under the title How to publish (or perish? (available at http://www.revistaiberoamericana.org/ojs/index.php/ibero/pages/view/publish%20or%20perish.

  14. An international survey and modified Delphi process revealed editors' perceptions, training needs, and ratings of competency-related statements for the development of core competencies for scientific editors of biomedical journals.

    Science.gov (United States)

    Galipeau, James; Cobey, Kelly D; Barbour, Virginia; Baskin, Patricia; Bell-Syer, Sally; Deeks, Jonathan; Garner, Paul; Shamseer, Larissa; Sharon, Straus; Tugwell, Peter; Winker, Margaret; Moher, David

    2017-01-01

    Background: Scientific editors (i.e., those who make decisions on the content and policies of a journal) have a central role in the editorial process at biomedical journals. However, very little is known about the training needs of these editors or what competencies are required to perform effectively in this role. Methods: We conducted a survey of perceptions and training needs among scientific editors from major editorial organizations around the world, followed by a modified Delphi process in which we invited the same scientific editors to rate the importance of competency-related statements obtained from a previous scoping review. Results: A total of 148 participants completed the survey of perceptions and training needs. At least 80% of participants agreed on six of the 38 skill and expertise-related statements presented to them as being important or very important to their role as scientific editors. At least 80% agreed on three of the 38 statements as necessary skills they perceived themselves as possessing (well or very well).  The top five items on participants' list of top training needs were training in statistics, research methods, publication ethics, recruiting and dealing with peer reviewers, and indexing of journals. The three rounds of the Delphi were completed by 83, 83, and 73 participants, respectively, which ultimately produced a list of 23 "highly rated" competency-related statements and another 86 "included" items. Conclusion: Both the survey and the modified Delphi process will be critical for understanding knowledge and training gaps among scientific editors when designing curriculum around core competencies in the future.

  15. A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module

    DEFF Research Database (Denmark)

    Weyer, Kathrin; Boldt, Henning B; Poulsen, Christine B

    2007-01-01

    -A cleaves IGFBP-4 and IGFBP-5, whereas PAPP-A2 cleaves only IGFBP-5. The pappalysins contain three Lin12-Notch repeat (LNR1-3) modules, previously considered unique to the Notch receptor family in which they function to regulate receptor cleavage. In contrast to the Notch receptor where three LNR modules...

  16. Diseño e implementación de servicios WFS y WMS para editores cartográficos

    OpenAIRE

    Sena García, Jéssica

    2010-01-01

    Este proyecto ha consistido en el diseño e implementación de servicios WFS y WMS siguiendo los estándares definidos por el Open Geospatial Consortium (OGC), y en el diseño e implementación de dos editores que los utilizan. El primero de ellos ha sido un editor de legalizaciones de la red eléctrica, basado en OpenLayers, y que ha sido integrado en otra aplicación ya existente en la empresa a la que iba destinado, Endesa. El segundo ha sido un editor de la red eléctrica, también basado en OpenL...

  17. Implementación de un editor gráfico de circuitos eléctricos con Qt

    OpenAIRE

    Martínez Muñoz, León Alberto

    2011-01-01

    Desarrollo de un Editor de Esquemas Eléctricos bajo el lenguaje de programación Qt que permite diseñar circuitos eléctricos para su posterior interpretación con un simulador de redes PLC. El Editor de Esquemas Eléctricos permita dibujar sobre un área de diseño un esquema eléctrico. El usuario dispone de cualquier componente eléctrico que pueda ser encontrado en una vivienda. Permite modificar los parámetros de cada componente utilizando los diferentes menús que ofrece la aplicación y expor...

  18. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors’ Network

    Directory of Open Access Journals (Sweden)

    Fernando Alfonso, MD

    2017-05-01

    Full Text Available The International Committee of Medical Journal Editors (ICMJE provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship -emphasizing the importance of responsibility and accountability-, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors’ Network of the European Society of Cardiology.

  19. Data sharing: A new editorial initiative of the International Committee of Medical Journal Editors. Implications for the editors’ network

    Directory of Open Access Journals (Sweden)

    Fernando Alfonso

    2017-06-01

    Full Text Available The International Committee of Medical Journal Editors (ICMJE provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship -emphasizing the importance of responsibility and accountability-, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors’ Network of the European Society of Cardiology.

  20. Apresentação sobre boas práticas editoriais para os editores científicos - UNINOVE

    OpenAIRE

    Silva, Altieres de Oliveira; Maccari, Emerson

    2015-01-01

    Com base nas discussões que foram apresentadas no Curso de Editoração Cientifica da Associação Brasileira de Editores Cientificos - ABEC, esta apresentação teve como objetivo orientar/ajudar os editores cientificos dos periódicos em Administração -UNINOVE. Contemplando os seguintes aspectos: gestão editorial; indexação; diretrizes para os autores; fator de impacto; redes sociais para alavancar a visibidade dos periódicos e artigos.