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Sample records for lichen planus treated

  1. Palmoplantar lichen planus successfully treated with acitretin.

    Science.gov (United States)

    Solak, Berna; Kara, Rabia Oztas; Kosem, Mustafa

    2015-09-07

    Palmoplantar lichen planus (PPL) is an uncommon type of lichen planus (LP) that exclusively affects the palms and soles. We report a case of a 50-year-old man who had palmoplantar hyperkeratotic papules and plaques. The patient was diagnosed as a case of PPL by skin biopsy, and treated with acitretin. He showed a good response to acitretin within 2 months. Clinical appearance and some features of PPL may differ from classic LP. Acitretin may be a favourable treatment option for PPL.

  2. Esophageal lichen planus

    OpenAIRE

    Oliveira,Janine Pichler de; Uribe, Natalia Caballero; Abulafia,Luna Azulay; Quintella, Leonardo Pereira

    2015-01-01

    Abstract Lichen planus is a chronic inflammatory disease that affects the skin, mucous membranes, nails and scalp. Esophageal lichen planus is a rarely reported manifestation of lichen planus, presenting itself commonly in middle-aged women, with symptoms such as dysphagia. We report a case of esophageal lichen planus in a 54-year-old woman associated with oral, cutaneous and ungual lichen planus. Although lichen planus is a disorder well known by dermatologists, reports of esophageal lichen ...

  3. Oral Lichen Planus

    Science.gov (United States)

    Oral lichen planus Overview By Mayo Clinic Staff Oral lichen planus (LIE-kun PLAY-nus) is an ongoing (chronic) ... that affects mucous membranes inside your mouth. Oral lichen planus may appear as white, lacy patches; red, ...

  4. Esophageal lichen planus.

    Science.gov (United States)

    Oliveira, Janine Pichler de; Uribe, Natalia Caballero; Abulafia, Luna Azulay; Quintella, Leonardo Pereira

    2015-01-01

    Lichen planus is a chronic inflammatory disease that affects the skin, mucous membranes, nails and scalp. Esophageal lichen planus is a rarely reported manifestation of lichen planus, presenting itself commonly in middle-aged women, with symptoms such as dysphagia. We report a case of esophageal lichen planus in a 54-year-old woman associated with oral, cutaneous and ungual lichen planus. Although lichen planus is a disorder well known by dermatologists, reports of esophageal lichen planus are rare in dermatologic literature. The esophageal lichen planus is little known and underdiagnosed, with a significant delay between the onset of symptoms and diagnosis.

  5. [Superimposed lichen planus pigmentosus].

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    Monteagudo, Benigno; Suarez-Amor, Óscar; Cabanillas, Miguel; de Las Heras, Cristina; Álvarez, Juan Carlos

    2014-05-16

    Lichen planus pigmentosus is an uncommon variant of lichen planus that is characterized by the insidious onset of dark brown macules in sun-exposed areas and flexural folds. Superimposed linear lichen planus is an exceedingly rare disorder, but it has been found in both lichen planopilaris and lichen planus types. A 39-year-old woman is presented showing a segmental and linear lichen planus associated with non-segmental lesions meeting all criteria for the diagnosis of superimposed linear planus pigmentosus. The segmental lesions were always more pronounced.

  6. Drug-Induced Lichen Planus Pigmentosus-Inversus Treated with Propolis Cream. A Case Report

    Directory of Open Access Journals (Sweden)

    Francisco Nelson Matos Figueredo

    2013-12-01

    Full Text Available Lichen planus has numerous clinical variants; one of them is lichen planus pigmentosus which is rarely mentioned in the medical literature. When located in the skin folds, it is known as lichen planus pigmentosus-inversus. In order to communicate a rare variant of lichen planus and its first presentation associated with drugs, we report the case of a 51 year-old mixed-race female patient from Latin America who was treated in the Department of Dermatology at the Celia Sanchez Manduley Clinical-Surgical Hospital in Granma. She presented with pigmented lesions in the inframammary folds that had evolved over several years. The clinical diagnosis was confirmed by histopathological elements. Some dermatoses with similar characteristics were dismissed. Treatment with propolis cream was beneficial.

  7. Carcinoma in cutaneous Lichen Planus

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    Rahul Shetty

    2013-01-01

    Full Text Available Carcinoma occurring in the cutaneous lesions of Lichen Planus though rarely mentioned in literature does occur and should be kept in mind while treating such lesions. We report a 16 year female who developed a squamous cell carcinoma in a long standing verrucous lichen planus in the lower leg. This case is being presented to indicate the possibility of malignant transformation of cutaneous lichen planus to carcinoma, especially in the hypertrophic forms and the need to have an early diagnosis so that it can be treated in the initial stages. A high degree of suspicion should be present whenever we come across a non healing lesion in a patient with lichen planus. A few markers, which may give us a clue for increased chances of malignant transformation in these cases is presented.

  8. Lichen planus pigmentosus.

    Science.gov (United States)

    Sehgal, Virendra N; Verma, Prashant; Bhattacharya, Sambit N; Sharma, Sonal; Rasool, Farhan

    2013-01-01

    Lichen planus pigmentosus, a variant of lichen planus, is a disorder with conflicting taxonomy. Its worldwide recognition is still not fully understood because of insufficient contemporary evidence of the disease in the literature. The authors review the historical background, etiopathogenesis, clinical connotation, atypical variants, and histopathology to highlight its diversity.

  9. Oral lichen planus: An overview.

    Science.gov (United States)

    Krupaa, R Jayasri; Sankari, S Leena; Masthan, K M K; Rajesh, E

    2015-04-01

    Lichen planus is an immunologically mediated mucocutaneous disease that is triggered by varied etiological agents. The oral lichenoid reaction is considered a variant of the disease that needs to be clearly diagnosed as a separate entity from oral lichen planus and treated. They follow a strict cause-effector relationship, protocols that suggest the differentiation. Lichen planus has varied clinical forms in the oral mucosa and cutaneously that has different prognosis. This condition also arises in association with various other systemic conditions such as hypertension, diabetes mellitus. There have been cases reported in the esophagus, larynx, scalp, nail, cutaneous areas, especially arms and wrists, trunk. There is reported malignant transformation that essentiates careful examination, treatment protocol and regular follow-up sessions. This article throws light on the disease condition of oral lichen planus and oral lichenoid reaction that is essential for the differentiation and treatment.

  10. Oral lichen planus: An overview

    Directory of Open Access Journals (Sweden)

    R Jayasri Krupaa

    2015-01-01

    Full Text Available Lichen planus is an immunologically mediated mucocutaneous disease that is triggered by varied etiological agents. The oral lichenoid reaction is considered a variant of the disease that needs to be clearly diagnosed as a separate entity from oral lichen planus and treated. They follow a strict cause-effector relationship, protocols that suggest the differentiation. Lichen planus has varied clinical forms in the oral mucosa and cutaneously that has different prognosis. This condition also arises in association with various other systemic conditions such as hypertension, diabetes mellitus. There have been cases reported in the esophagus, larynx, scalp, nail, cutaneous areas, especially arms and wrists, trunk. There is reported malignant transformation that essentiates careful examination, treatment protocol and regular follow-up sessions. This article throws light on the disease condition of oral lichen planus and oral lichenoid reaction that is essential for the differentiation and treatment.

  11. A RARE CASE OF LICHEN PLANUS PEMPHIGOIDES

    OpenAIRE

    Ashok,, S.K; Anjali

    2014-01-01

    Lichen planus pemphigoides describe a rare subset of patients who usually have typical lichen planus and then develop blistering on their lichen planus lesions and in normal skin. Less commonly the blistering antedates the lichen planus. They clinically appear to be a combination of lichen planus and bullous phemphigoid. Oral disease may occur and may resemble either lichen planus or bullous phemphigoid. Histopathologically, lichen planus lesions show features of lichen pl...

  12. Interventions for treating oral lichen planus: a systematic review.

    Science.gov (United States)

    Lodi, G; Carrozzo, M; Furness, S; Thongprasom, K

    2012-05-01

    Oral lichen planus (OLP) is a common chronic inflammatory disease associated with cell-mediated immunological dysfunction. Symptomatic OLP is painful and complete healing is rare. The aim of this review was to assess the evidence for the efficacy and safety of treatments for symptomatic OLP. The Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched in January 2011 to identify all randomized controlled trials (RCTs) evaluating any intervention for the treatment of symptomatic OLP. A total of 28 trials were included in this Cochrane review. There was no evidence from three RCTs that topical pimecrolimus is better than placebo in reducing pain from OLP. There was weak evidence from two RCTs that topical aloe vera may be associated with a reduction in pain compared with placebo. There was weak and unreliable evidence from two small trials, at high risk of bias, that topical ciclosporin may reduce pain and clinical signs of OLP. There was no evidence (from five trials each evaluating a different steroid and/or calcineurin inhibitor) that there is a difference between treatment with topical corticosteroids (TCSs) compared with topical calcineurin inhibitors with regard to reducing pain associated with OLP or that any specific steroid therapy is more or less effective at reducing pain. Although TCSs are considered to be the first-line treatment, we did not identify any RCTs that compared TCSs with placebo in patients with symptomatic OLP. From the 28 trials included in this systematic review, the wide range of interventions compared means there is insufficient evidence to support the superior effectiveness of any specific treatment.

  13. Squamous Cell Carcinoma Developing in a Cutaneous Lichen Planus Lesion: A Rare Case

    OpenAIRE

    Saptarshi Ghosh; Sivasankar Kotne; Ananda Rao, P. B.; Turlapati, S. P. V.; Dillip Kumar Soren

    2014-01-01

    Lichen planus is a benign disorder characterized by an itchy, noninfectious skin rash. Though lichen planus is a common papulosquamous disorder affecting about 1-2% of the population, neoplastic transformation of cutaneous lichen planus lesions occurs very rarely and should be borne in mind while treating nonhealing longstanding lesions of lichen planus. Studies suggest an estimated 0.3–3% risk of malignancy in patients with oral lichen planus, however, cutaneous lichen planus does not carry ...

  14. Coexistence of nail lichen planus and lichen planus pigmentosus*

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    Lemes, Luciana Rodino; Verde, Renata Brandão Villa; Durães, Sandra Maria Barbosa; Araripe Junior, Adolpho de Alencar; Pantaleão, Luciana

    2016-01-01

    We describe a fifty-six-year old, Afro-descendent female patient showing dystrophy of her twenty nails and hyperchromic, asymptomatic macule on her face. Histopathological examination of the macule showed vacuolization of the basal layer, melanophages in the superficial dermis and lymphoplasmocytic inflammatory infiltrate. Nail biopsy revealed orthokeratotic hyperkeratosis and lichenoid inflammatory infiltrate. Lichen planus pigmentosus is an uncommon variety of lichen planus. It is characterized by typical hyperpigmented macules on the face and neck. Nail changes might be present in 10% of lichen planus cases, but no associations with lichen planus pigmentosus have been described. We report a case of lichen planus in twenty nails associated with lichen planus pigmentosus on the patient's face.

  15. Zosteriform Lichen Planus: case report of a rare variant of Lichen Planus

    OpenAIRE

    Kanthilatha Pai; Sathish Pai

    2013-01-01

    Since its original description by Devergie in 1854, several cases of linear lichen planus have been described in the literature, but there have been notably few cases of the more rare zosteriform lichen planus. Zosteriform lichen planus needs to be differentiated from linear lichen planus and other linear dermatoses. We present a case of Zosteriform Lichen planus for its rarity and briefly review literature.

  16. Erosive lichen planus: a therapeutic challenge*

    OpenAIRE

    Romero, Williams; Giesen,Laura; Navajas-Galimany, Lucas; Gonzalez, Sergio

    2016-01-01

    Abstract Erosive lichen planus is an uncommon variant of lichen planus. Chronic erosions of the soles, accompanied by intense and disabling pain, are some of its most characteristic manifestations. We present the case of a woman who developed oral and plantar erosive lichen planus associated with lichen planus pigmentosus and ungueal lichen planus that were diagnosed after several years. The patient failed to respond to multiple therapies requiring longstanding medication but remained refract...

  17. Case report and review of esophageal lichen planus treated with fluticasone.

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    Ynson, Marie Lourdes; Forouhar, Faripour; Vaziri, Haleh

    2013-03-14

    Lichen planus is a fairly common chronic idiopathic disorder of the skin, nails and mucosal surfaces. Esophageal involvement of this disease on the other hand is rare and only about 50 cases have been reported in literature. Given its rarity, it can be difficult to diagnose and may be easily misdiagnosed as reflux esophagitis. Currently, there are no clear recommendations on the optimal management of this disease and little is known about the best treatment approach. Systemic steroids are usually the first line treatment and offer a favorable response. In this report, we would like to present a novel approach in the management of esophageal lichen planus in a middle-aged woman treated successfully with swallowed fluticasone propionate 220 mcg twice a day for 6 wk, as evidenced by objective clinical findings. Based on our review of related literature and experience in this patient, we feel that a trial of swallowed fluticasone may be a prudent approach in the management of these patients since it has a more favorable side effect profile than systemic treatment.

  18. Erosive lichen planus: a therapeutic challenge.

    Science.gov (United States)

    Romero, Williams; Giesen, Laura; Navajas-Galimany, Lucas; Gonzalez, Sergio

    2016-01-01

    Erosive lichen planus is an uncommon variant of lichen planus. Chronic erosions of the soles, accompanied by intense and disabling pain, are some of its most characteristic manifestations. We present the case of a woman who developed oral and plantar erosive lichen planus associated with lichen planus pigmentosus and ungueal lichen planus that were diagnosed after several years. The patient failed to respond to multiple therapies requiring longstanding medication but remained refractory. Knowledge of the treatment options for erosive lichen planus is insufficient. Further research is required to clarify their effectiveness, ideally adopting an evidence-based methodology.

  19. Clinical variants of lichen planus.

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    Wagner, Gunnar; Rose, Christian; Sachse, Michael Max

    2013-04-01

    Lichen planus is characterized by lichenoid, polygonal papules with fine white lines, called Wickham striae. Lesions most commonly occur on the limbs and on the dorsal aspect of the trunk. At the same time often leukoplakia of mucous membranes as well as nail disorders are seen. There are numerous variants of lichen planus which can be distinguished from the classical form on the basis of morphology and distribution of the lesions. The typical primary lesion of lichen planus may be replaced by other forms, such as patches, hyperkeratoses, ulcerations, or bullous lesions. Moreover, distribution patterns of these lesions may vary and include erythrodermic, inverse or linear arrangements. In contrast to these numerous clinical features, histologic findings remain characteristic in the variants, so that the diagnosis can be made securely. Differential diagnoses of lichen planus include diverse dermatoses such as bullous pemphigoid or paronychia.

  20. Oral candidosis in lichen planus

    DEFF Research Database (Denmark)

    Kragelund, Camilla; Kieffer-Kristensen, L; Reibel, J;

    2012-01-01

    OBJECTIVES: Candida albicans is the most common fungal pathogen in humans, but other Candida species cause candidosis. Candida species display significant differences in their susceptibility to antimycotic drugs. Patients with symptomatic or erythematous oral lichen planus (OLP) commonly have...

  1. Palmar lichen planus mimicking tinea nigra

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    Bhushan Madke

    2013-01-01

    Full Text Available Lichen planus (LP is a chronic inflammatory skin disease characterized by polygonal, violaceous papules commonly involving flexural areas of the wrists, legs, and oral and genital mucous membranes. This report describes a patient who presented with asymptomatic black colored patches on both palms simulating Tinea nigra, a superficial fungal infection. She was previously diagnosed as allergic contact dermatitis and was being treated with potent topical steroid i.e. clobetasol propionate 0.05% and white soft paraffin. Dermatoscopy of the lesion showed brownish pigmentation along ridges of the dermatoglyphics. A biopsy from the lesional skin showed findings of lichen planus. Our case highlights the potential diagnostic confusion that can occur with unusual variants of palmoplantar lichen planus and importance of histopathology in diagnosis of such unusual lesions.

  2. Treatment of esophageal stricture due to lichen planus with intralesional corticosteroid injection.

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    Köksal, Aydin S; Yildiz, Hakan; Odemiş, Bülent; Sengül, Ayşegül

    2014-02-01

    Herein we presented a male patient with esophageal stricture due to lichen planus successfully treated with repeated injections of intralesional triamcinolone and review the current literature on esophageal lichen planus with special emphasis on its treatment.

  3. Twice malignant transformation of hypertrophic lichen planus.

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    Krasowska, Dorota; Kozłowicz, Katarzyna; Kowal, Małgorzata; Kurylcio, Andrzej; Budzyńska-Włodarczyk, Jolanta; Polkowski, Wojciech; Chodorowska, Grażyna

    2012-01-01

    Lichen planus is a chronic mucocutaneous T-cell-mediated disease, the cause of which remains unknown. The first case of lichen planus that transformed into squamous cell carcinoma was reported in 1903. The presented study concerns the case of a 62-year-old woman in whom twice malignant transformation of hypertrophic lichen planus in the dorsal part of the left foot developed. Several studies have pointed out the malignant transformation potential of lichen planus. Epidemiological studies from the last 20 years have revealed a malignant transformation rate of 0.27% per year, emphasizing the importance of the clinical follow-up of lichen planus patients.

  4. Becker nevus with vitiligo and lichen planus: Cocktail of dermatoses

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    Sanjeev Gupta

    2010-07-01

    Full Text Available Context: Becker nevus has been reported to be associated with lichen planus (LP in isolated case reports in past. The association of LP and vitiligo has been noted in few cases and has been attributed to a common autoimmune etiology. The coexistence of lichen planus, vitiligo and Becker nevus has not been reported so far. Case Report: A thirty five years old male presented with lesions of Becker nevus along with vitiligo and Lichen planus coexisting at one place on right side of the chest. Vitiligo and Becker nevus could not be treated. Lichen planus was confirmed histopathologically. We were able to treat lichen planus with topical potent steroids, tacrolimus and systemic antihistamines. The vitiligo lesion in our case was resistant to treatment. Conclusion: This case is being reported for the rare occurrence of three different well defined skin conditions in our patient and reviews the possible known etiological factors for their coexistence.

  5. Cutaneous lichen planus: A systematic review of treatments.

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    Fazel, Nasim

    2015-06-01

    Various treatment modalities are available for cutaneous lichen planus. Pubmed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, and Health Technology Assessment Database were searched for all the systematic reviews and randomized controlled trials related to cutaneous lichen planus. Two systematic reviews and nine relevant randomized controlled trials were identified. Acitretin, griseofulvin, hydroxychloroquine and narrow band ultraviolet B are demonstrated to be effective in the treatment of cutaneous lichen planus. Sulfasalazine is effective, but has an unfavorable safety profile. KH1060, a vitamin D analogue, is not beneficial in the management of cutaneous lichen planus. Evidence from large scale randomized trials demonstrating the safety and efficacy for many other treatment modalities used to treat cutaneous lichen planus is simply not available.

  6. Diagnosis and treatment of lichen planus.

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    Usatine, Richard P; Tinitigan, Michelle

    2011-07-01

    Lichen planus is a chronic, inflammatory, autoimmune disease that affects the skin, oral mucosa, genital mucosa, scalp, and nails. Lichen planus lesions are described using the six P's (planar [flat-topped], purple, polygonal, pruritic, papules, plaques). Onset is usually acute, affecting the flexor surfaces of the wrists, forearms, and legs. The lesions are often covered by lacy, reticular, white lines known as Wickham striae. Classic cases of lichen planus may be diagnosed clinically, but a 4-mm punch biopsy is often helpful and is required for more atypical cases. High-potency topical corticosteroids are first-line therapy for all forms of lichen planus, including cutaneous, genital, and mucosal erosive lesions. In addition to clobetasol, topical tacrolimus appears to be an effective treatment for vulvovaginal lichen planus. Topical corticosteroids are also first-line therapy for mucosal erosive lichen planus. Systemic corticosteroids should be considered for severe, widespread lichen planus involving oral, cutaneous, or genital sites. Referral to a dermatologist for systemic therapy with acitretin (an expensive and toxic oral retinoid) or an oral immunosuppressant should be considered for patients with severe lichen planus that does not respond to topical treatment. Lichen planus may resolve spontaneously within one to two years, although recurrences are common. However, lichen planus on mucous membranes may be more persistent and resistant to treatment.

  7. Aloe vera as cure for lichen planus.

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    Patil, Bharati A; Bhaskar, Hebbar Pragati; Pol, Jyoti S; Sodhi, Amandeep; Madhu, Asha V

    2013-01-01

    Oral lichen planus is a difficult condition to treat because of its chronic nature. Various treatment modalities have resulted in partial regression of symptoms but not a complete cure. Aloe vera, a product with minimal adverse effects, can be tried to treat this disorder. A 38-year-old male patient diagnosed with lichen planus of the skin and the oral mucosa was suffering from severe pain and a burning sensation intraorally and pruritus of the skin lesions. Considering the extensive involvement, an herbal alternative was considered. The patient was prescribed aloe vera juice and gel application for two months. At the nine-month follow-up, the patient was symptom-free and totally cured of the intraoral and skin lesions.

  8. A Case of Lichen Planus Pigmentosus-Inversus

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    Belkız Uyar

    2012-09-01

    Full Text Available Lichen planus pigmentosus is a rare subtype of lichen planus. Because of its rarity, we present the case of a patient diagnosed as lichen planus pigmentosus-inversus based on clinical and histopatological findings, which clinical appearance did not resemble lichen planus at initial examination.

  9. A Case of Lichen Planus Pigmentosus-Inversus

    OpenAIRE

    Belkız Uyar; Oya Nermin Sivrikoz

    2012-01-01

    Lichen planus pigmentosus is a rare subtype of lichen planus. Because of its rarity, we present the case of a patient diagnosed as lichen planus pigmentosus-inversus based on clinical and histopatological findings, which clinical appearance did not resemble lichen planus at initial examination.

  10. A CLINICAL AND HISTOPATHOLOGICAL STUDY OF LICHEN PLANUS

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    Ch. Madhu Babu; Padmaja, P.; M. Roopa Shree

    2016-01-01

    BACKGROUND Lichen planus is an idiopathic subacute or chronic inflammatory disease of the skin, mucous membranes, and nails. We studied the clinicopathological profile of 50 cases of Lichen planus in Osmania General Hospital from September 2010-April 2012. METHODS A total of 50 cases Lichen planus attending DVL OPD at OGH were studied. Clinical features like age, sex, type of Lichen planus, location were recorded in the case record form. Histological features of Lichen planus...

  11. Comparative Observation on the Effects of Radix Tripterygium Hypoglaucum Tablet and Tripterygium Glycosides Tablet in Treating Erosive Oral Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    LIN Li-mei; QI Xiang-min

    2005-01-01

    Objective: To compare the therapeutic effects of Radix Tripterygium hypoglaucum tablet (THT) and Tripterygium glycosides tablet (TGT) in treating erosive oral lichen planus( EOLP). Methods: The patients were randomized into two groups, and they were treated with THT ( n = 47) or TGT ( n = 47), respectively. The therapeutic effects were evaluated after 3 months treatment. Results: For the patients of grade 1, the total efficacy in TGT group was 85.71%, compared with 52.38% in THT group, the efficacy was statistically greater in the group receiving TGT (P = 0. 043). However, for the patients of grade 2, the difference was not statistically significant (P = 0. 173). Conclusion: TGT is more effective in treating EOLP than THT for grade 1 patients. However, TGT is. not suitable for patients of child bearing age.

  12. Cicatrizing conjunctivitis associated with paraneoplastic lichen planus.

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    Hahn, J M; Meisler, D M; Lowder, C Y; Tung, R C; Camisa, C

    2000-01-01

    To report two cases of cicatrizing conjunctivitis associated with paraneoplastic lichen planus. Case reports. Two patients were examined because of redness and discomfort in both eyes. A 63-year-old woman with follicular, small-cleaved cell lymphoma had cicatrizing conjunctivitis, stomatitis, vulvitis, and skin lesions. A 25-year-old man with malignant thymoma had cicatrizing conjunctivitis, erosive stomatitis, and penile papules. Histopathologic studies of conjunctiva and skin biopsy specimens in the first patient and labial biopsy specimens in the second revealed lichen planus. Paraneoplastic lichen planus is a possible cause of cicatrizing conjunctivitis associated with inflammatory skin and mucous membrane disease.

  13. Systemic complications of esophageal lichen planus.

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    Manna, R; Garcovich, S; Giovinale, M; Marinaro, A; Manganelli, C; Zampetti, A; Feliciani, C

    2013-01-01

    Lichen planus is an uncommon inflammatory mucocutaneous disorder affecting the skin and its appendages, as well as oral and genital mucosa. Involvement of the esophageal mucosa is rare and causes significant morbidity, with dysphagia and risk of long-term complications, such as esophageal strictures and stenosis. Esophageal lichen planus is an underreported condition in the spectrum of lichenoid tissue reactions, presenting the risk of systemic manifestations. We describe a patient with severe, long-standing esophageal lichen planus, which had led to marked weight-loss, malnutrition syndrome and chronic respiratory distress due to recurrent aspiration pneumonia. Diagnosis was confirmed by the presence of concomitant muco-cutaneous lesions and characteristic endoscopic and histological findings. Systemic therapy with cyclosporine A and micronutrient supplementation led to rapid clinical improvement. Early diagnosis of esophageal lichen planus as well as effective systemic immunosuppressive treatment is crucial in order to prevent short- and long-term complications.

  14. Implant retained overdentures for two patients with severe lichen planus: a clinical report.

    Science.gov (United States)

    Esposito, Salvatore J; Camisa, Charles; Morgan, Michael

    2003-01-01

    Lichen planus is a common inflammatory mucocutaneous disease that often manifests itself intraorally. Oral lichen planus can appear in many forms; the most significant form for the edentulous patient is the erosive variety. For the patient, wearing a complete denture is quite dramatic because of the friability of the tissue. Implant-supported overdentures are a predictable treatment for edentulous patients, but this has been discouraged for the patient with erosive lichen planus. This article describes 2 patients with oral erosive lichen planus who were successfully treated with implant-retained mandibular overdentures.

  15. Squamous Cell Carcinoma Developing in a Cutaneous Lichen Planus Lesion: A Rare Case

    Directory of Open Access Journals (Sweden)

    Saptarshi Ghosh

    2014-01-01

    Full Text Available Lichen planus is a benign disorder characterized by an itchy, noninfectious skin rash. Though lichen planus is a common papulosquamous disorder affecting about 1-2% of the population, neoplastic transformation of cutaneous lichen planus lesions occurs very rarely and should be borne in mind while treating nonhealing longstanding lesions of lichen planus. Studies suggest an estimated 0.3–3% risk of malignancy in patients with oral lichen planus, however, cutaneous lichen planus does not carry an increased risk of malignant degeneration. We present a case of a 36-year-old male with a 10-year-long history of hypertrophic lichen planus who presented with a nonhealing ulcer in the left popliteal fossa. The patient underwent wide local excision with superficial skin grafting. Postoperative histopathological examination revealed verrucous squamous cell carcinoma complicating lichen planus. In view of underlying structure involvement, adjuvant radiation therapy was given. This case is being reported to emphasize the infrequent possibility of development of malignancy in cutaneous lichen planus, especially if it presents as a longstanding, nonhealing, itchy lesion with patchy areas of depigmentation in the lower limbs.

  16. Squamous cell carcinoma developing in a cutaneous lichen planus lesion: a rare case.

    Science.gov (United States)

    Ghosh, Saptarshi; Kotne, Sivasankar; Ananda Rao, P B; Turlapati, S P V; Kumar Soren, Dillip

    2014-01-01

    Lichen planus is a benign disorder characterized by an itchy, noninfectious skin rash. Though lichen planus is a common papulosquamous disorder affecting about 1-2% of the population, neoplastic transformation of cutaneous lichen planus lesions occurs very rarely and should be borne in mind while treating nonhealing longstanding lesions of lichen planus. Studies suggest an estimated 0.3-3% risk of malignancy in patients with oral lichen planus, however, cutaneous lichen planus does not carry an increased risk of malignant degeneration. We present a case of a 36-year-old male with a 10-year-long history of hypertrophic lichen planus who presented with a nonhealing ulcer in the left popliteal fossa. The patient underwent wide local excision with superficial skin grafting. Postoperative histopathological examination revealed verrucous squamous cell carcinoma complicating lichen planus. In view of underlying structure involvement, adjuvant radiation therapy was given. This case is being reported to emphasize the infrequent possibility of development of malignancy in cutaneous lichen planus, especially if it presents as a longstanding, nonhealing, itchy lesion with patchy areas of depigmentation in the lower limbs.

  17. Lichen planus pigmetosus-like ashy dermatosis

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    Francesco Tripodi Cutrì

    2011-12-01

    Full Text Available Ashy dermatosis, also known as erythema dyschromicum perstans, is an idiopathic dermal melanosis of unknown etiology. We here describe an unusual case of 63-year-old Caucasian male with ashy dermatosis and skin lesion of lichen pigmentosus-like. No treatment was tried because the lesions were totally asymptomatic. After a control, three months later, all lesions had cleared up. This case is of interest because it proves the existence of ashy dermatosis with clinical aspect lichen planus pigmentosus-like. This is the first case in the literature of lichen planus pigmentosuslike ashy dermatosis confirming the view that ashy dermatosis is a variant of lichen planus without the typically band-like infiltrate and Max Joseph spaces.

  18. Lichen Planus-a Clinico-histopathological

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    Garg Vijay

    2000-01-01

    Full Text Available The clinico-histopathological features of 75 patients of lichen planus were studied. The male to female ratio was 1:13. The largest number of patients (30.6% fell into the 31-40 year age group. Two patients had systemic hypertension. There was no history of lichen planus in the family. All patients presented with severe itching within 1-2 months of onset. Papular lesions were seen in 72% and papules with plaques were seen 16%. Lower limbs were involved in 38% of cases. Mucosal involvement was seen in 24% in addition to skin involvement ; nail involvement hypertrophicus (17.3%. Lichen planopilaris and oral lichen planus were uncommon. Clinico-histopathological discrepancies were observed in 7 patients. Civatte bodies were seen in only 37% of cases.

  19. Profile of lichen planus in Bangladesh.

    Science.gov (United States)

    Khondker, L; Wahab, M A; Khan, S I

    2010-04-01

    Lichen planus is one of the common inflammatory disorders of skin, mucous membrane, nail and hair characterized by violaceous, polish, pruritic, polygonal, flat-topped papules usually distributed bilaterally symmetrically over the extremities. Our objectives in this study were to explore the prevalence of lichen planus in large area of Dhaka in Bangladesh and to establish the clinical characteristics of lichen planus. This descriptive type of cross sectional study was carried out from September 2006 to August 2008 in the Department of Dermatology and Venereology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka Medical College Hospital (DMCH) and Combined Military Hospital (CMH) in Dhaka. Patients suffering from lichen planus were selected as study population. By face to face interview and clinical observations, data were collected from sample. A total 120 patients of lichen planus were selected, on the basis of age, 30(25%) were 10-30 years of age, 75(62.56%) were 30-50 years and 16(13.33%) were over 50 years of age. The mean age of the patient was 40+/-4 years. Out of 120 patients, 80(66.66%) were male and 60(33.33%) were female and eight patients (6.67%) had positive family history among highest age group (30 to 50 years). In case of duration of disease, highest percentage (68%) of cases was 15 days to 6 months and considering clinical sign, koebnerization was present 45(37.5%) cases and Wickhams striae 22(18.33%) cases. Regarding site of onset of lesion, lesions were highest 100(83.33%) in upper limbs, next lower limbs, trunk, oral mucosa etc. The distribution of clinical pattern of lichen planus showing classic pattern (68.33%) was the most common type, followed by hypertrophic, actinic, ashy dermatoses, lichen plano-pilaris, erosive or ulcerative etc. This clinico-epidemiological study of lichen planus attending in the different hospital in Dhaka, Bangladesh has shown that lichen planus is usually associated with 30 to 50 years of age group, with

  20. Lichen planus secondary to hepatitis B vaccination

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    Agrawal Akhilesh

    2004-07-01

    Full Text Available The association of lichen planus (LP with liver diseases is now well established. Recent reports suggest that the hepatitis viruses may play a central role in this association. Lichen planus following hepatitis B vaccination is much more unusual. A 19-year-old previously healthy male developed itchy violaceous papules and plaques over the upper extremities eight to ten days after the first injection of hepatitis B vaccine. He developed similar lesions over the upper trunk, neck and lower leg after the second and third injections. A skin biopsy showed a lichenoid tissue reaction. Direct immunofluorescence (DIF showed multiple colloid bodies and a strong continuous ragged basement membrane zone (BMZ band with fibrinogen. HbsAg by ELISA and anti-HCV antibodies were negative. The patient was treated with oral steroids and the lesions improved. LP is a pruritic inflammatory dermatosis of unknown origin. An increased prevalence of liver disease in patient with LP has been reported. Since the first case reported by Rebora in 1990, about 15 cases of LP occurring after hepatitis B vaccination have been reported in the literature irrespective of the type of vaccine used.

  1. Lichen Planus Pemphigoides Associated with Bisoprolol

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    Turna İlknur

    2012-06-01

    Full Text Available Lichen planus pemphigoides (LPP is a disease characterized by tense bullae arising on lichen planus papules and on clinically uninvolved skin, lichenoid infiltration and subepidermal bulla in histopathology, and linear deposits of IgG and C3 along basal membrane zone on direct immunofluorescence. This rare bullous dermatosis is usually idiopathic. However, in a few cases in the literature, it has been reported to be induced by hepatitis B, malignancies, phototherapy and some medications such as ramipril, captopril, cinnarizine and simvastatin. We reported a 35-year-old woman with LPP possibly induced by bisoprolol.

  2. Vulval lichen planus leading to urethral stenosis

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    Mishra M

    1996-01-01

    Full Text Available An 8-year-old female child presented with difficulty in micturition preceded by some vulval lesions. She had itching around vulva associated with burning sensation and gradually developed a whitish patch. Histology was compatible with lichen planus.

  3. A case with Lichen planus in the lines of Blaschko

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    Metehan Gençoğlu

    2011-12-01

    Full Text Available Lichen planus is an inflammatory disorder that may involveskin and mucous membranes. Linear lichen planusis a rare disorder occurring in approximately 0.2% of patientswith lichen planus. We report a case of linear lichenplanus on the upper extremity which lesions followed thelines of Blaschko. J Clin Exp Invest 2011; 2 (4: 430-432

  4. Painful linear atrophic lichen planus along lines of Blaschko

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    Lakshmi Chembolli

    2006-01-01

    Full Text Available Linear lichen planus along the lines of Blaschko is uncommon. Atrophic lichen planus is usually a sequel to resolving annular and ulcerative lesions. We herewith report a case of histopathologically proven lichen planus, presenting with atrophy at the outset, in a linear distribution along the lines of Blaschko. In addition to the cutaneous findings, she also had pain along the distribution of lesions.

  5. Linear lichen planus in children--case report.

    Science.gov (United States)

    Horowitz, Marcia Raquel; Vidal, Marcela de Lima; Resende, Manuela Oliveira; Teixeira, Márcia Almeida Galvão; Cavalcanti, Silvana Maria de Morais; Alencar, Eliane Ruth Barbosa de

    2013-01-01

    Lichen planus is an uncommon disease in children, and only 2 to 3% of affected patients are under twenty years of age. This dermatosis may appear in several clinical forms, which vary according to the morphology and distribution of lesions. In less than 0.2% of all lichen planus cases, the lesions are distributed along the lines of Blaschko, and is a variant called linear lichen planus. This is a case report of a patient aged two years and eight months, who presented keratotic violaceous papules, affecting the abdomen, buttocks and right thigh, distributed along the lines of Blaschko. Histopathological examination confirmed a diagnosis of linear lichen planus.

  6. Levamisole Monotherapy for Oral Lichen Planus

    Science.gov (United States)

    Won, Tai Hyok; Park, Se Young; Kim, Bo Suk; Seo, Phil Seung

    2009-01-01

    Background Several different kinds of drugs have been used to treat chronic oral lichen planus (OLP). During the last decade, there have been several reports demonstrating success with levamisole and low dose prednisolone therapy for treating OLP. However, some OLP patients who have underlying diseases such as diabetes, hypertension and malignancy are unable to take steroids. Objective The aim of this study was to evaluate levamisole monotherapy for treating OLP. Methods Eleven patients who had OLP were treated with levamisole between 2005 and 2007. The levamisole was administered at a dose 50 mg thrice daily for three consecutive days, but then it was not administered on the following four days. Results After 2 weeks of treatment, 8 patients reported a partial response, 3 patients reported no response and no patients reported clearance of lesion. After 4 weeks of treatment, 6 patients reported a partial response, 3 patients reported no response and 2 patients reported clearance of lesion. Furthermore, after 3 months of treatment, 3 patients reported a partial response, 3 patients reported no response and 5 patients reported complete clearance of lesion. Clinical improvement was shown in 2 weeks, whilst the mean duration to achieve clearance of lesion was 6.2 weeks. Although 1 patient had mild itching, there were no significant adverse effects. Conclusion Levamisole monotherapy could be a successful and safe treatment option for patients with chronic OLP and who cannot take steroids. PMID:20523798

  7. Lichen planus: an update and review.

    Science.gov (United States)

    Sharma, Amit; Białynicki-Birula, Rafał; Schwartz, Robert A; Janniger, Camila K

    2012-07-01

    Lichen planus (LP) is a papulosquamous eruption of the skin, scalp, nails, and mucous membranes. Although LP is more common in adults, it has become an established pediatric disorder. Its classic presentation is characterized by 4 p's: purple, polygonal, pruritic papules. Histopathologic examination reveals characteristic interface dermatitis. Although its pathogenesis is not fully understood, there is evidence that an imbalance of immunologic cellular reactivity is central. Lichen planus usually resolves within a few months. Treatment that primarily consists of topical and/or oral steroids will expedite recovery and alleviate symptoms. Resolution of this cutaneous disease often is accompanied by postinflammatory hyperpigmentation. Long-term sequelae of LP in the pediatric population are rare, but cutaneous atrophy and pterygium unguis may occur.

  8. A STUDY ON LICHEN PLANUS IN CHILDREN

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    Neerja Puri

    2013-07-01

    Full Text Available Introduction: Lichen planus is considered to be rare in children. However, it does not appear to be uncommon in Indian subcontinent. Aims: The study was undertaken to analyse the clinical profile of childhood lichen planus. Material and Methods: We selected 30 children with LP for the study. The children selected were below the age of 14 years of age. Results and Discussion: In our study, it was seen that that the maximum onset of disease was between 5-9 years of age and mean age of children with LP was 6.8 years. The commonest type of LP in children was classical LP seen in 60% children, followed by actinic LP in 20% children. LP hypertrophicus and linear LP were seen in 10% patients each. Nail changes were seen in 10% patients.

  9. Dapsone versus corticosteroids in lichen planus

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    Chopra Adarsh

    1999-01-01

    Full Text Available Seventy five patients with Lichen Planus (LP were enrolled from out-patient department for screening the therapeutic effect of dapsone. Patients were divided into two groups of 50 and 25. In regimen - 1 (RI 25 patients were given local corticosteroids and oral chlorpheniramine maleate. In regimen - 2 (R2 50 patients were given oral dapsone and chlorpheniramine maleate and topical coconut oil. It was found that total efficacy of R2 was 18% higher than R1.

  10. Narrowband UVB-induced lichen planus pemphigoides

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    Wai Man Mandy Chan

    2011-10-01

    Full Text Available Lichen planus pemphigoides (LPP is an autoimmune disease characterised by evolution of subepidermal blisters on normal and lichen planus affected skin. We describe a case of LPP in a 54-year-old Chinese woman. The patient presented with psoriasiform plaques and was diagnosed with guttate psoriasis. Narrowband ultraviolet B (NBUVB therapy was commenced, and she experienced a generalised eruption of violaceous papules, bullae over the lower limbs, and Wickham’s striae over the buccal mucosa. Histology from a plaque revealed interface dermatitis, while a specimen from a blister showed subepidermal bulla. Direct immunofluorescence showed linear deposition of IgG and C3 along the basement membrane. A diagnosis of LPP was made on clinicopathological grounds. This is the first case report of NBUVB alone in unmasking LPP. In this case report, we describe the pathological mechanism of NBUVB in the development of LPP and key features distinguishing LPP from bullous lupus erythematosus, bullous lichen planus, bullous pemphigoid, and psoriasis.

  11. Palmoplantar hyperkeratotic lesions: a rare presentation of lichen planus.

    Science.gov (United States)

    Almodovar-Real, Ana; Aneiros-Fernández, Jose; Molina-Leyva, Alejandro; Fernandez-Pugnaire, Ma Antonia

    2015-03-15

    Palmoplantar lichen planus is a localized and rare subtype of lichen planus (LP) often underdiagnosed. Several morphological types of palmoplantar lesions have been defined in LP. We present an unusual case of the palmoplantar kyperkeratotic variant of LP. Histopathology examination confirmed our diagnosis. We emphasize the importance of this rare entity in the differential diagnosis of palmoplantar dermatoses.

  12. Etiology and pathogenesis of oral lichen planus: an overview.

    Science.gov (United States)

    Kurago, Zoya B

    2016-07-01

    Oral lichen planus is a noninfectious, chronic inflammatory condition that involves the oral mucosal stratified squamous epithelium and the underlying lamina propria and may be accompanied by skin lesions. This overview describes the current understanding of the immunopathologic mechanisms implicated in oral lichen planus.

  13. Mycophenolate mofetil in erosive genital lichen planus: a case and review of the literature.

    Science.gov (United States)

    Deen, Kristyn; McMeniman, Erin

    2015-03-01

    Erosive genital lichen planus is a disabling, inflammatory mucocutaneous condition that can cause significant patient morbidity and loss of function. Treatment initially involves topical corticosteroids but some patients can have severe treatment-resistant courses requiring systemic immunosuppression. With potentially unfavorable adverse effect profiles and subsequent intolerance of these agents by patients, erosive lichen planus can ultimately be a challenging condition to treat effectively. We present a case of a 66-year-old woman with treatment-resistant erosive genital lichen planus who was successfully managed with mycophenolate mofetil. Although there is only weak evidence for this agent in this condition, its role in dermatology is growing due to its efficacy and advantageous adverse effect profile and should therefore be considered in patients with treatment-resistant erosive genital lichen planus.

  14. Use of Low Level Laser Therapy for Oral Lichen Planus: Report of Two Cases

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    Mahdavi O.

    2013-12-01

    Full Text Available Oral Lichen Planus is a chronic inflammatory disease of unknown etiology. Erosive/ ulcerative oral lichen planus is often a painful condition that tends to become malignant, urging appropriate therapy. Laser therapy has recently been suggested as a new treatment option without significant side effects. This article presents two cases of erosive/ ulcerative oral lichen planus, who had not received any treatment before, treated with 630 nm low level laser. Lesion type and pain was recorded before and after treatment. Severity of lesions and pain were reduced after treatment. Low Level Laser Therapy was an effective treatment with no side effects and it may be considered as an alternative therapy for erosive/ulcerative oral lichen planus.

  15. Use of low level laser therapy for oral lichen planus: report of two cases.

    Science.gov (United States)

    Mahdavi, O; Boostani, N; Jajarm, Hh; Falaki, F; Tabesh, A

    2013-12-01

    Oral Lichen Planus is a chronic inflammatory disease of unknown etiology. Erosive/ ulcerative oral lichen planus is often a painful condition that tends to become malignant, urging appropriate therapy. Laser therapy has recently been suggested as a new treatment option without significant side effects. This article presents two cases of erosive/ ulcerative oral lichen planus, who had not received any treatment before, treated with 630 nm low level laser. Lesion type and pain was recorded before and after treatment. Severity of lesions and pain were reduced after treatment. Low Level Laser Therapy was an effective treatment with no side effects and it may be considered as an alternative therapy for erosive/ulcerative oral lichen planus.

  16. Surgical management of vulvovaginal agglutination due to lichen planus.

    Science.gov (United States)

    Fairchild, Pamela S; Haefner, Hope K

    2016-02-01

    Lichen planus is a rare dermatological disorder that is often associated with painful and disfiguring vulvovaginal effects. At the University of Michigan Center for Vulvar Diseases, we see many women with vulvovaginal lichen planus each year, with marked scarring and vulvovaginal agglutination that precludes vaginal intercourse and causes difficulty with urination. Through our experience, we developed a protocol for the operative management and postoperative care for severe vulvovaginal agglutination. Our objective is to share this protocol with a wider audience so that providers who see patients with these devastating effects of lichen planus can benefit from our experience to better serve this patient population. The figure represents a case of erosive lichen planus with early vaginal agglutination. The video reviews the pathophysiology and presentation of lichen planus. We then present a case of scarring and agglutination in a young woman, including our surgical management and postoperative care recommendations.

  17. Lichen planus pigmentosus: two atypical presentation

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    Falguni Nag

    2013-01-01

    Full Text Available Lichen planus pigmentosus (LPP is a chronic pigmentary disorder with variable pattern of presentation. We here by present two cases of LPP one with parallel band like pigmentation over abdomen sparing the abdominal skin creases and other with parallel band like pattern following the Blaschko’s lines over left side of the abdomen. Our cases are unique not only for its presentation but also for the pattern of distribution and LPP should be the differential diagnosis in any pigmentary disorders.

  18. Oral lichen planus and lichenoid mucositis.

    Science.gov (United States)

    De Rossi, Scott S; Ciarrocca, Katharine

    2014-04-01

    Oral lichen planus (OLP) is commonly found in middle-aged women. Although the cause is unknown, research points to several complex immunologic events and cells that are responsible for the inflammatory destruction and chronicity of these lesions. Biopsy for histologic diagnosis is recommended. The mainstay of treatment remains topical corticosteroids; however, newer therapies such as immunomodulating agents are available for recalcitrant lesions. In cases of lichenoid mucositis or reactions, treatment should be directed at identifying and removing the presumed cause. Given the apparent risk of squamous cell carcinoma in these patients, frequent follow-up and repeat biopsy are vital.

  19. Lichen planus and lupus erythematosus overlap syndrome

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    Chopra Adarsh

    1996-01-01

    Full Text Available A 45-year-old woman with livid plaques showing central atrophy and erythematous vesicular borders over both dorsa of feet and buttocks, and follicular and papular lesions over buttocks and lumbar area, was difficult to diagnose as either lichen planus (LP or lupus erythematosus (LE. The histological studies from two places showed features of both LE and LP. Laboratory findings were within normal limits first, but follow up studies for two years showed persistent albuminurea, leucopenia, arthritis and erythema over the exposed areas with same histology suggesting that eruption may be an unusual variant of LE.

  20. A potential peptide pathway from viruses to oral lichen planus.

    Science.gov (United States)

    Lucchese, Alberta

    2015-06-01

    Oral lichen planus is an idiopathic inflammatory disease of oral mucous membranes, characterized by an autoimmune epidermis attack by T cells. It remains unknown, however, how such aggressive T cells are activated in vivo to cause epidermal damage. This study analyzes the relationship at the peptide level between viruses and oral lichen planus disease. Four potentially immunogenic peptides (SSSSSSS, QEQLEKA, LLLLLLA, and MLSGNAG) are found to be shared between HCV, EBV, HHV-7, HSV-1, and CMV and three human proteins (namely pinin, desmoglein-3, and plectin). The described peptide sharing might be of help in deciphering the still unexplained immunopathogenic pathway that leads to oral lichen planus.

  1. Lichen planus remission is associated with a decrease of human herpes virus type 7 protein expression in plasmacytoid dendritic cells

    OpenAIRE

    de Vries, H J C; Teunissen, M.B.M.; Zorgdrager, F.; Picavet, D.; Cornelissen, M

    2007-01-01

    The cause of lichen planus is still unknown. Previously we showed human herpes virus 7 (HHV-7) DNA and proteins in lesional lichen planus skin, and significantly less in non-lesional lichen planus, psoriasis or healthy skin. Remarkably, lesional lichen planus skin was infiltrated with plasmacytoid dendritic cells. If HHV-7 is associated with lichen planus, then HHV-7 replication would reduce upon lichen planus remission. HHV-7 DNA detection was performed by nested PCR and HHV-7 protein by imm...

  2. VCAM1 and ICAM1 expression in oral lichen planus.

    Science.gov (United States)

    Seyedmajidi, Maryam; Shafaee, Shahryar; Bijani, Ali; Bagheri, Soodabeh

    2013-01-01

    Oral lichen planus is a chronic inflammatory immune-mediated disease. ICAM-1 and VCAM-1 are vascular adhesion molecules that their receptors are located on endothelial cells and leukocytes. The aim of this study is the immunohistochemical evaluation of VCAM1 and ICAM1 in oral lichen planus and to compare these two markers with normal mucosa for evaluation of angiogenesis. This descriptive-analytical study was performed on 70 paraffined blocks of oral lichen planus and 30 normal mucosa samples taken from around the lesions. Samples were stained with H & E and then with Immunohistochemistry using monoclonal mouse anti human VCAM1 (CD106), & monoclonal mouse anti human ICAM1(CD54) for confirmation of diagnosis. Slides were evaluated under light microscope and VCAM1 and ICAM1 positive cells (endothelial cells and leukocytes) were counted. Data were analyzed with Mann-Whitney test, Wilcoxon and Chi-Square and plichen planus according to the percentage of stained cells (p=0.000& p=0.000, Mann-Whitney test). Thirty cases of oral normal mucosa associated with lichen planus showed that the VCAM1 has increased significantly in comparison to normal mucosa (plichen planus and normal mucosa, showed a significantly difference (plichen planus was not observed (p>0.05). Regarding the results, it seems that high expression of VCAM1 and ICAM1 is related to oral lichen planus.

  3. LICHEN PLANUS WITH ASSOSIATED SQUAMOUS CELL CARCINOMA IN THE ORAL MUCOSA

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    Valluvan

    2014-06-01

    Full Text Available Lichen means dry scurfy forms of lower plant life and the same name indicate dry skin disorder like lichen planus. The basic histological feature of lichen planus is basal layer damage and inflammatory reaction in the sub epithelial zone. There are several sub types 0.5% of mucosal lichen planus can become or harbor invasive squamous cell carcinoma

  4. [Verrucous squamous cell carcinoma complicating hypertrophic lichen planus. Three case reports and review of the literature].

    Science.gov (United States)

    Friedl, T K; Flaig, M J; Ruzicka, T; Rupec, R A

    2011-01-01

    Lichen planus is a chronic mucocutaneous T-cell-mediated disease, whose cause is still unknown. The first case of lichen planus that transformed into squamous cell carcinoma was reported in 1903. We present three patients in whom squamous cell carcinomas were identified in chronic lichen planus. The world literature includes at least 91 cases, including our three cases. In an epidemiological study, no significant risk of transformation of cutaneous lichen planus into squamous cell carcinomas was found. In contrast, there is a significantly higher risk of malignant transformation in mucosal lichen planus, so that the WHO had graded mucosal lichen planus as a premalignant condition.

  5. Classical lichen planus and lichen planus pigmentosus inversus overlap with dermoscopic features

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    Şule Güngör

    2014-01-01

    Full Text Available A 35-year-old man was referred to our hospital with a 3 months history of itchy cutaneous eruption on the trunk and asymptomatic cutaneous eruption on both groins. Physical examination revealed several, purplish-brown, scaly papules on the trunk and well-circumscribed, brown patchs in a linear distribution, on the bilateral inguinal regions. Dermoscopic examination of papules on the trunk revealed white crossing lines surrounded by brown dots; dermoscopic examination of patchs on groins revealed gray-brown dots and globules. According to histological, dermoscopical and clinical changes, the diagnoses of classical lichen planus (LP for the lesions on the trunk; and lichen planus pigmentosus inversus (LPPI for the lesions on the inguinal regions were made. Inhere we have described a rare case of LPPI and classical LP with dermoscopic features; and we suggest that LPPI is a variant of classical LP.

  6. Bullous oral lichen planus: report of two cases

    Institute of Scientific and Technical Information of China (English)

    Berrin (U)NSAL; S. Elif G(U)LTEKIN; Erol BAL; Benay TOKMAN

    2003-01-01

    @@ Lichen planus is a common chronic mucocutaneous disease of unknown cause. Several types of lichen planus (reticular, atrophic, erosive and bullous) within the oral cavity have been described, among which the reticular and erosive types are the most common types,1,2 while the bullous type is rarely observed.1,3 Bullous lichen planus (BLP) lesions are commonly seen on the buccal mucosa, most frequently at the posterior areas adjacent to the second and third molar teeth. Less common localizations are gingiva and inner aspect of the lips.4 Bullae are generally short lived and leave ulcerated lesions on rupturing.1 The clinical diagnosis of bullous lichen planus is extremely difficult, and pathological examinations may be necessary to establish a definitive diagnosis.5

  7. [Dynamic concept of oral lichen planus. The diagnosis easy at early stages may become difficult in ancient lichen planus].

    Science.gov (United States)

    Lombardi, Tommaso; Küffer, Roger

    2016-02-01

    Dynamic concept of oral lichen planus. The diagnosis easy at early stages may become difficult in ancient lichen planus. Lichen planus is a chronic inflammatory dermatosis of the skin, skin appendages and mucous membranes, which frequently affects the oral mucosa. Its aetiology still remains unknown, and currently accepted pathogenesis is that of an autoimmune cell-mediated disease. To the contrary of skin lichen planus, oral lichen planus is a long-term chronic disease with dynamic evolution, in which progressive and profound changes of the clinical and histopathological aspects occur over time and under the influence of various exogenous factors. By convention, in the history of the oral lichen planus four successive stages can be distinguished without well-defined boundaries between them. These stages can be defined as an initial phase; a long intermediate phase with alternating periods of activity and quiescence, which has a gradually increasing risk of malignant transformation; a late stage which activity is traditionally diminished; and a post-lichen cicatricial stage with an absent or negligible and undetectable activity, often undiagnosed because clinically unrecognized; in this stage, the lesion does not respond to usual treatments, but retains the same risk of malignant transformation.

  8. Oral lichen planus and stress: An appraisal

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    Simarpreet V Sandhu

    2014-01-01

    Full Text Available Introduction: Oral lichen planus (OLP is a chronic inflammatory disease characterized by bilateral white striations or plaques on the buccal mucosa, tongue or gingiva that has a multifactorial etiology, where the psychogenic factors seem to play an important role. Purpose: The aim of this study was to determine the existing relation between the OLP and psychological alterations of the patient, such as stress, anxiety, and depression. Materials and Methods: Hospital anxiety and depression scale was applied for psychometric analysis. Results: The study indicates a definitive relationship between a stressful life event and onset and progression of OLP. Conclusion: Stress management and bereavement counseling should be a part of management protocol of OLP.

  9. Isolated ocular lichen planus in a child.

    Science.gov (United States)

    Igras, Estera; Kennedy, Susan; MacDermott, Emma Jane; Murphy, Conor C

    2015-08-01

    Lichen planus (LP) is an autoimmune inflammatory condition of the skin and mucous membranes, of unknown aetiology, that infrequently involves the eye. Ocular LP has not been described in children. We present the case of an 8-year-old girl with severe, filamentous dry eyes and persistent conjunctival hyperemia with bilateral progressive conjunctival symblepharon. Her conjunctival biopsy showed heavy linear fibrinogen deposits along the basement membrane without IgG, IgA, IgM, or C3 deposition, consistent with LP. No skin or other mucosal lesions were present, suggesting a diagnosis of isolated conjunctival LP. Oral and topical cyclosporine combined with methotrexate and low-dose oral steroids led to sustained disease remission. To our knowledge, this is the first case of isolated ocular LP in a child.

  10. Wolf's isotopic response, presenting as lichen planus*

    Science.gov (United States)

    Queiroz, Mariana Thomaz da Silva; de Almeida, José Roberto Paes; Sementilli, Ângelo; Dinato, Sandra Lopes Mattos e; Romiti, Ney

    2015-01-01

    The term "Wolf's isotopic response" describes the occurrence of a new skin disorder at the site of another unrelated and already healed skin disease. In most cases, herpes zoster is the inicial disease. Different disorders may develop on the same site, most commonly granulomatous and lichenoid reactions, infiltration of hematologic diseases, skin tumors and infections. There are few related cases of lichen planus presenting as isotopic response. We report a case of a 74 year-old woman, with multiple itchy, rose-colored and shiny papules that developed at site of previously healed herpes zoster, on the right arm and shoulder. The pathogenesis of this phenomenon is still unknown and further studies are needed. PMID:26312684

  11. Hyperkeratotic palmoplantar lichen planus in a child

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    Bhushan Madke

    2013-01-01

    Full Text Available Lichen planus (LP is a common idiopathic inflammatory disorder that affects the flexor aspect of the wrists, the legs, and the oral and genital mucosa. Depending upon the site of involvement, LP can be divided into mucosal, nail, scalp, or palmoplantar types. Palmoplantar LP can pose a diagnostic problem to the clinician as it resembles common dermatoses like psoriasis, verruca, corn, calluses, lichenoid drug eruption, and papular syphilide of secondary syphilis. In this case report, we describe a 4-year-old male child who presented with highly pruritic erythematous to violaceous hyperkeratotic papules and plaques on his palms and soles. Typical LP papules were noted on the upper back. Histopathology of the papular lesion showed features of LP. Dermatoscopy of a papule from the back showed the characteristic Wickham striae. We report this rare involvement of palm and soles in a case of childhood LP.

  12. Bilateral Linear Lichen Planus Pigmentosus Associated with Hepatitis C Virus Infection

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    Vasanop Vachiramon

    2010-09-01

    Full Text Available Lichen planus pigmentosus is a rare subtype of lichen planus. We report a first case of lichen planus pigmentosus with bilateral linear distribution associated with hepatitis C virus infection. The lesion was improved after sun avoidance and treatment of hepatitis C virus infection with a combination of interferon and ribavirin. This case stresses the importance of screening for hepatitis C virus infection as lichen planus pigmentosus can be an associated condition.

  13. The Evaluation of Psychosocial Factors Associated with Oral Lichen Planus

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    Farhad Mollashahi Leila

    2009-09-01

    Full Text Available Background: Lichen planus is a chronic mucocutaneous disease that often affects the oral mucosa.However, the exact etiology and pathogenesis remain unclear, there are reports about the association between Oral Lichen Plans (OLP and immunological disorders and psychological factors. The role of psychosocial factors especially depression and anxiety in oral lichen planus is debated. This study was done to determine the association of these factors in oral lichen planus.Materials and Methods: This descriptive study was done in department of oral medicine of Zahedan University of Dentistry from May 2007 to May 2008. One hundred and sixty patients were evaluated in three groups of OLP, negative control and positive control using Beck Anxiety (BAI, Beck Depression (BDI and Stress Life Event Questionnaires. Data were analyzed using Kruskal Wallis and Mann-Whitney tests. P value0.05.Conclusions: It seems that psychosocial factors may have role in the causation of oral lichen planus. These factors may form a starting point for initiation of various autoimmune reactions, which have been shown to be contributory to the pathogenesis of oral lichen planus

  14. Lichen planus remission is associated with a decrease of human herpes virus type 7 protein expression in plasmacytoid dendritic cells

    NARCIS (Netherlands)

    de Vries, H.J.C.; Teunissen, M.B.M.; Zorgdrager, F.; Picavet, D.; Cornelissen, M

    2007-01-01

    The cause of lichen planus is still unknown. Previously we showed human herpes virus 7 (HHV-7) DNA and proteins in lesional lichen planus skin, and significantly less in non-lesional lichen planus, psoriasis or healthy skin. Remarkably, lesional lichen planus skin was infiltrated with plasmacytoid d

  15. Líquen plano oral Oral lichen planus

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    Marcello Menta Simonsen Nico

    2011-08-01

    Full Text Available O líquen plano da mucosa oral (LPO é afecção relativamente comum, que pode aparecer isolado ou associado ao líquen plano cutâneo, havendo, no entanto, significantes diferenças clínicoevolutivas: o LPO tende a ser crônico, recidivante e de difícil tratamento, levando a importante morbidade, principalmente em sua forma erosiva. Novas formas clínicas agressivas têm sido salientadas na literatura, como a forma gingivo-vulvar. Este artigo revisa a etiopatogenia, as formas clínicas, a diagnose diferencial e laboratorial, a prognose e o tratamento do LPO, além de mencionar, brevemente, a experiência dos autores com esta enfermidade, vivida no Ambulatório de Estomatologia da Divisão de Dermatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloOral lichen planus (OLP is a relatively common mucosal disease that can present isolated or associated with cutaneous lichen planus. Contrarily to its cutaneous counterpart, though, OLP tends to be chronic, relapsing, and difficult to treat. Severe morbidity is related to erosive forms, and more aggressive presentations have been described, such as the "gingivo-vulvar syndrome". This article reviews the current knowledge about the pathogenesis, clinical picture, differential and laboratorial diagnosis, prognosis, and treatment of OLP

  16. The relationship between oral lichen planus and gastrointestinal symptoms

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    Mandana Khatibi

    2016-03-01

    Full Text Available Background: Gastrointestinal complications, followed by involvement of gastrointestinal tract with oral lichen planus, are one of the problems of the patients with oral lichen planus. Gastrointestinal symptoms should be evaluated to reject malignancy probability (1-5%. Given lack of information and different reported frequencies in Iran and other countries, this study was conducted in order to evaluate the relationship between oral lichen planus and gastrointestinal symptoms in Razi hospital in Tehran. Methods: This case-control study was performed on 50 patients with oral lichen planus and 50 controls by observation, clinical examination and biopsy, if necessary. Both groups were similar in sex, age, smoking, alcohol abuse and lack of systemic diseases. Gastrointestinal (GI symptoms such as dysphagia, odynophagia, hunger pain, heartburn, flatus, etc. Were evaluated. Data were analyzed by SPSS statistical software using chi–square, Exact Fisher and T-student tests. Results: Of 50 cases (OLP, 32(64% patients and among 50 controls, 16 (32% patients were found to have GI symptoms. Hunger pain (18% and heartburn (18% were the most common symptoms. Also, there was a significant difference in the prevalence of gastrointestinal symptoms between the two groups (P<0.005, Conclusion: Gastrointestinal complications can be a part of mifestations of lichen planus and OLP. Knowledge of gastrointestinal symptoms in OLP patients can be helpful in preventing the G.I tract obstruction and malignancy by on time treatment.

  17. Lichen planus and Hepatitis C: a case-control study

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    Ghodsi S Zahra

    2004-05-01

    Full Text Available Abstract Background The association of lichen planus with hepatitis C (HCV has been widely reported in the literature. However, there are wide geographical variations in the reported prevalence of HCV infection in patients with lichen planus. This study was conducted to determine the frequency of hepatitis C in Iranian patients with lichen planus at Razi hospital, Tehran. Methods During the years 1997 and 1998, 146 cases of lichen planus, 78 (53.1% women and 69 (46.9% men were diagnosed. They were diagnosed on the basis of the usual clinical features and, if necessary, typical histological findings. The patients were screened for the presence of anti-HCV antibodies by third generation ELISA and liver function tests. We used the results from screening of blood donors for anti HCV (carried out by Iranian Blood Transfusion Organization for comparison as the control group. Results Anti-HCV antibodies were detected in seven cases (4.8%. This was significantly higher than that of the blood donors' antibodies (p Conclusion HCV apears to have an etiologic role for lichen planus in Iranian patients. On the other hand, liver function tests are not good screening means for HCV infection.

  18. Vulvovaginal-gingival Lichen Planus: Association with Lichen Planopilaris and Stratified Epithelium-specific Antinuclear Antibodies.

    Science.gov (United States)

    Olszewska, Malgorzata; Banka-Wrona, Agnieszka; Skrok, Anna; Rakowska, Adriana; Górska, Renata; Solomon, Lynn W; Rudnicka, Lidia

    2016-01-01

    Vulvovaginal-gingival lichen planus (VVG-LP) consists of a triad of symptoms: vulval, vaginal and gingival lichen planus lesions. The aim of this study was to analyse the prevalence of lesions in various anatomical locations in patients with VVG-LP. The study included 126 consecutive patients with lichen planus. Sixteen (12.7%) patients fulfilled the criteria of VVG-LP. In 12/16 (75%) patients with VVG-LP scalp lesions were also observed. Stratified epithelium-specific antinuclear antibodies (SES-ANA) and anti-ΔNp.3α antibodies were detected in 10/16 (75%) patients with VVG-LP and in 15/110 (13.6%) patients with other forms of lichen planus (p lichen planopilaris. The new entity may be termed "vulvovaginal-gingival-pilar lichen planus" and our study indicates that SES-ANA is a marker of this type of lichen planus with extensive, severe and refractory-to-therapy involvement of the mucous membranes, skin and scalp.

  19. Expression of Apoptosis Related Protein in Skin Lesions of Lichen Planus and Its Implication

    Institute of Scientific and Technical Information of China (English)

    Xu'e CHEN; Yan WU; Jiawen LI; Zhixiang LIU; Qing YUE; Houjun LIU

    2008-01-01

    In order to investigate the role of Caspase-3 and Bax in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of Caspase-3 and Bax in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rate of Caspase-3 and Bax expression in lichen planus were significantly higher than that in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of Caspase-3 and that of Bax in lichen planus. The expression of Caspase-3 and Bax might play an important role in the development of lichen planus.

  20. Graham Little-Lassueur Syndrome with Hypertrophic Lichen Planus in a Patient with Chronic Hepatitis C

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    Badea Mihail Alexandru

    2016-03-01

    Full Text Available Graham Little-Lassueur Syndrome (GLLS is considered a form of lichen planopilaris which associates follicular lichen planus, cicatricial alopecia of the scalp and noncicatricial alopecia of the axillary and/or pubic regions. We present the case of a 47 years old female patient, known for 5 years with chronic hepatitis C and a poor therapeutic control of the disease due to Interferon intolerance. She presented to our clinic for the occurrence on the shins of some well-defined, intensely pruritic erythematous plaques, covered with thick scales, with a verrucous appearance, accompanied by excoriations. The skin biopsy reveal hypertrophic lichen planus on the shins and lichen planopilaris on the scalp. The patient was treated with systemic antihystamines, topical corticosteroids and salicylic acid under occlusion, emollients, phototherapy UVB narrow band 4 sessions/week for 3 weeks, cryotherapy. From our knowledge this is the first case of GLLS associated with chronic viral hepatis C.

  1. Association of Helicobacter pylori with lichen planus

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    Moravvej Hamideh

    2007-01-01

    Full Text Available Background : Lichen planus (LP is a common idiopathic, inflammatory disorder that affects the skin, mucous membranes, nails and hair. Clinical observations and anecdotal reports have suggested a relationship between the exposure to a number of exogenous agents and the development of LP. One of the most important suggested bacterial etiologies is Helicobacter pylori (HP, that is one of the most common bacterial infections in the world, which is also reported to be common in Iran. Objective : This study was performed to evaluate the relation between HP and LP. Materials and Methods: A case control study was conducted with 80 patients with LP to find out a previous history of HP and 80 patients with other skin diseases were examined with urea breath test (UBT as controls. Results: Sixty-six patients with LP and 49 patients from the controls had positive UBT. There was a significant difference about UBT positive result between these two groups. Conclusion: According to study, these results support a definitive etiological role for HP in LP.

  2. Predominant palmoplantar lichen planus: A diagnostic challenge

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    Rameshwar Gutte

    2014-01-01

    Full Text Available Background: Palmoplantar lesions in lichen planus (LP are uncommon. In such cases, diagnosis is usually missed. This study was conducted to document various clinical and histopathological features of palmoplantar LP. Materials And Methods: A total of 18 patients from our outpatient department with lesions of LP, either predominantly or exclusively on palms and/or soles were studied. Patients with history of drug intake in recent past and patients with classical acute widespread LP with a few lesions on palms or soles were excluded. In each patient, diagnosis was made on clinicopathological correlation. Various clinical and histopathological features were analyzed. Results: Average age of onset was 38 years. Male: female ratio was 1:0.6 and average disease duration was 11 months. Exclusive palm or sole involvement was seen in 4/18 patients. Itching was the most common symptom. Clinically the most common variant was hypertrophic. Histologically presence of parakeratosis, spongiosis, lack of melanophages, and lack of hypergranulosis in some cases was seen in addition to classical features of LP. In 3 out of 4 patients with exclusive palmoplantar involvement diagnosis of LP was missed clinically. Conclusion: Involvement of palms and soles in LP poses a diagnostic challenge due to variable presentations. Histopathology is of vital importance for correct diagnosis and treatment.

  3. Active inflammatory biomarkers in oral lichen planus.

    Science.gov (United States)

    Santarelli, Andrea; Mascitti, Marco; Rubini, Corrado; Bambini, Fabrizio; Zizzi, Antonio; Offidani, Annamaria; Ganzetti, Giulia; Laino, Luigi; Cicciù, Marco; Lo Muzio, Lorenzo

    2015-12-01

    Oral lichen planus (OLP) is a chronic disease, with a central role to cell-mediated autoimmunity. Osteopontin promotes migration and recruitment of immune cells, CD44 is its receptor, and Survivin seems to be important in skin/mucosa homeostasis. The aim of this study was to investigate their expression in biopsy specimens of patients with different OLP clinical types and healthy controls.Biopsy specimens from 30 patients with OLP (15 atrophic and 15 hyperplastic) and 15 healthy controls were subjected to immune-histochemical analysis, to detect the expression of osteopontin, CD44, and Survivin in oral epithelia. The distributions of positively stained cells were evaluated with a quantitative method, while the inflammation degree was evaluated with a semi-quantitative one.Expression of osteopontin and CD44 was higher in OLP than controls, while Survivin expression was lower in OLP patients. There was a greater reduction of Survivin expression in atrophic OLP than hyperplastic OLP. A correlation between osteopontin expression and a high degree of inflammation was found. Furthermore, Survivin expression was higher in cases with low intensity of inflammation.Osteopontin, CD44, and Survivin seem to be involved in OLP pathogenesis, and further investigations are needed for clarifying their role in this oral disease.

  4. Oral lichen planus: focus on etiopathogenesis.

    Science.gov (United States)

    Payeras, Márcia Rodrigues; Cherubini, Karen; Figueiredo, Maria Antonia; Salum, Fernanda Gonçalves

    2013-09-01

    Lichen planus is a chronic mucocutaneous inflammatory disease, which frequently affects the oral mucosa of white females over 40 years old. Its aetiology remains uncertain and the pathogenesis is still the object of much speculation. The present paper presents the most well known antigens, and describes the action of different cells and proteins associated with the development of that disease, as well as the possible agents involved with its malignant transformation. Different external agents, especially virus, and internal agents, like stress, and the heat shock protein antigen expression, associated or not, can alter the basal keratinocytes of the oral mucosa making them susceptible to apoptosis by CD8(+) cytotoxic T cell as well as activate matrix metalloproteinase and mast cell degranulation, which produce a great range of inflammatory mediators and cytokines determining the clinical onset of the disease. Regarding carcinogenesis, since it is a complex process and presents multifactorial origin, it is believed that there may be a synergism between intrinsic, such as inflammation mediators, and extrinsic agents (tobacco, alcohol, viral infections) for the OLP malignant transformation to occur. However, further studies are needed to better understand the origin, pathogenesis and process of malignant transformation of OLP.

  5. Nail lichen planus in a patient with alopecia totalis.

    Science.gov (United States)

    Ginsberg, Brian A; Yost, John Montgomery; Lewin, Jesse; Hale, Christopher S; Meehan, Shane A; Carucci, John A; Ramachandran, Sarika

    2014-12-16

    A 67-year-old man with a three-year history of non-scarring alopecia that progressed to alopecia totalis despite intralesional glucocorticoid injections is presented. He developed 20-nail dystrophy that was recalcitrant to antifungal and anti-inflammatory treatments. Biopsy of the nail matrix showed histopathologic features of lichen planus. Alopecia totalis and isolated lichen planus of the nails are uncommon subtypes of common dermatologic disorders. Rarely reported concurrently, we provide a review of the literature of their association, which is most likely attributed to their autoimmune pathogeneses.

  6. Lichen planus pemphigoides induced by a weight reduction drug.

    Science.gov (United States)

    Rosmaninho, Aristoteles; Sanches, Madalena; Oliveira, Ana; Alves, Rosario; Selores, Manuela

    2011-12-01

    Lichen planus pemphigoides is a rare autoimmune dermatosis characterized by bullous lesions arising on lichen planus (LP) papules and on clinically uninvolved skin, coexistence of histological features of LP and bullous pemphigoid and linear deposits of IgG and/or C3 along the basal membrane zone on direct immunofluorescence of peribullous skin. LPP has been reported to be associated with several medications such as ramipril, cinnarizine, simvastatin, captopril, psoralen ultraviolet A therapy and antituberculous medications. We report a case of a 41-year-old woman with LPP associated with a weight reduction drug.

  7. FIELD CANCERIZATION IN LICHEN PLANUS – AN UNUSUAL CASE REPORT

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    Tamgadge Avinash

    2012-12-01

    Full Text Available Lichen Planus is a muco-cutaneous disorder affecting females. The oral lesions precede the skin lesions, with malignant potential rate, ranging from 0.3 to 3%. Malignant changes are usually associated with stress and cocarcinogens. Usually, malignant transformation is presented as solitary lesion in the oral cavity, Oral Squamous Cell Carcinoma (OSCC, developing at multiple sites, as a very rare finding in patients of Oral Lichen Planus (OLP. A case of OLP without risk factors and strong history of stress, the Grinspan syndrome with field cancerization is presented in this article

  8. Update on oral lichen planus: etiopathogenesis and management

    DEFF Research Database (Denmark)

    Scully, C; Beyli, M; Ferreiro, M C

    1998-01-01

    Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its......-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations...

  9. Update on lichen planus and its clinical variants

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    Gillian Weston, MSIII

    2015-08-01

    Full Text Available Lichen planus (LP is an inflammatory skin condition with characteristic clinical and histopathological findings. Classic LP typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques; many variants in morphology and location also exist, including oral, nail, linear, annular, atrophic, hypertrophic, inverse, eruptive, bullous, ulcerative, lichen planus pigmentosus, lichen planopilaris, vulvovaginal, actinic, lichen planus-lupus erythematosus overlap syndrome, and lichen planus pemphigoides. Clinical presentation of the rarer variant lesions may be largely dissimilar to classic LP and therefore difficult to diagnose based solely on clinical examination. However, histopathological examination of LP and LP-variant lesions reveal similar features, aiding in the proper diagnosis of the disease. Management of LP and LP variants aims to control symptoms and to decrease time from onset to resolution; it often involves topical corticosteroids, but varies depending on the severity and location of the lesion. The literature contains an array of reports on the variations in presentation and successful management of LP and its variants. A familiarity with LP and its variants is important in achieving timely recognition and management of the disease.

  10. Association of oral lichen planus with hepatitis C virus, surface antigen of hepatitis B virus, and diabetes: A clinical and biochemical study

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    Pavani Donempudi

    2016-01-01

    and HBsAg. However, there was a slight increase in the incidence of HCV in oral lichen planus when compared with controls. Therefore, oral lichen planus patients should be evaluated for the presence of these diseases and vice versa so that it can be diagnosed in early stages and treated accurately.

  11. ON THE PROBLEM OF THE TREATMENT OF GENITAL LICHEN PLANUS

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    Yu. A. Molochkova

    2016-01-01

    Full Text Available Lichen planus is a chronic inflammatory disease of the coated flat nonkeratinizing epithelium of the skin and mucous membranes. Still etiology of this disease is not completely clear. At the same time, many researchers have expressed their views in favor of the theory of occurrence of autoimmune planus. The emergence of this disease may also be associated with infectious diseases, trauma, hormonal disorders, and hereditary predisposition. Currently, standard treatment of lichen planus is topical application of corticosteroids. With the lack of effectiveness of the last clinicians suggest topical calcineurin inhibitors. That less, all treatments planus today are ineffective. Researchers continue to search for more effective treatments for this pathology. At this point in the treatment of various diseases is well proven photodynamic therapy. Given the high efficacy of photodynamic therapy in the treatment of basal cell carcinoma, actinic keratosis and various other skin diseases, clinicians began to fully explore the impact of the use of photodynamic therapy in the treatment of lichen planus.

  12. Lichen planus pigmentosus: The controversial consensus

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    Aparajita Ghosh

    2016-01-01

    Full Text Available A pigmented variant of lichen planus (LP was first reported from India in 1974 by Bhutani et al. who coined the term LP pigmentosus (LPP to give a descriptive nomenclature to it. LP has a number of variants, one of which is LPP. This disease has also later been reported from the Middle East, Latin America, Korea, and Japan, especially in people with darker skin. It has an insidious onset. Initially, small, black or brown macules appear on sun-exposed areas. They later merge to form large hyperpigmented patches. The disease principally affects the sun-exposed areas of the body such as the face, trunk, and upper extremities. The oral mucosa may rarely be involved. However, the palms, soles, and nails are not affected. Histologically, the epidermis is atrophic along with vacuolar degeneration of basal cell layer. The dermis exhibits incontinence of pigment with scattered melanophages and a sparse follicular or perivascular infiltrate. There is a considerable similarity in histopathological findings between LPP and erythema dyschromicum perstans. However, there are immunologic and clinical differences between the two. These observations have led to a controversy regarding the identity of the two entities. While some dermatologists consider them to be the same, others have opined that the two should be considered as distinctly different diseases. A number of associations such as hepatitis C virus infection, frontal fibrosing alopecia, acrokeratosis of Bazex and nephrotic syndrome have been reported with LPP. A rare variant, LPP inversus, with similar clinical and histopathological findings was reported in 2001. As opposed to LPP, this variant occurs in covered intertriginous locations such as groins and axillae and mostly affects white-skinned persons.

  13. Methotrexate for treatment of lichen planus: old drug, new indication.

    Science.gov (United States)

    Kanwar, A J; De, D

    2013-03-01

    Treatment of generalized lichen planus is often disappointing and is associated with relapses. Though reports have suggested a beneficial role of various immunosuppressive and immunomodulatory agents, most of these reports are retrospective series or anecdotes. Oral methotrexate has been found to be useful in recent studies. In this study, we prospectively evaluated the role of low-dose oral methotrexate (15 mg/week in adults or 0.25 mg/kg/week for children) in generalized lichen planus. Mean improvement in 24 evaluated patients (two of them were of paediatric age group) at the end of 14 weeks of treatment was 79%. By the end of 24 weeks treatment, 14 of 24 (58%) patients had complete remission of their disease. Side effects were observed in 12 of 24 (50%) patients. Most of these adverse effects were mild; only one requiring treatment discontinuation due to significantly deranged liver function test. During post-treatment follow-up of 3 months, none had relapse of lichen planus. Overall, low- dose methotrexate is effective and reasonably safe option in treatment of eruptive lichen planus, provided haematological and biochemical parameters are regularly monitored.

  14. Comparison of topical tretinoin and betamethasone in oral lichen planus

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    Kar H

    1996-01-01

    Full Text Available Thirty-one patients of oral lichen planus were enrolled in this study and two groups were made. Group 1 consisting of 16 patients who applied topical tretinoin 0.05% and Group 2 comprising of 15 patients who were given topical betamethasone dipropionate 0.05%. The patients applying tretinoin showed statistically significant improvement as compared to patients applying betamethasone.

  15. CO2 laser evaporation of oral lichen planus

    NARCIS (Netherlands)

    van der Hem, P. S.; Egges, M.; van der Wal, J. E.; Roodenburg, J. L. N.

    2008-01-01

    Oral lichen planus is a relatively common disease of the oral mucosa. The buccal mucosa and lateral border of the tongue are mostly involved, although the condition can occur anywhere in the oral cavity. The erosive type in particular can cause spontaneous pain during eating. In the period from 1975

  16. Disease scoring systems for oral lichen planus; a critical appraisal

    NARCIS (Netherlands)

    Wang, J.; van der Waal, I.

    2015-01-01

    The aim of the present study has been to critically review 22 disease scoring systems (DSSs) on oral lichen planus (OLP) that have been reported in the literature during the past decades. Although the presently available DSSs may all have some merit, particularly for research purposes, the diversity

  17. Disease scoring systems for oral lichen planus; a critical appraisal

    NARCIS (Netherlands)

    Wang, J.; van der Waal, I.

    2015-01-01

    The aim of the present study has been to critically review 22 disease scoring systems (DSSs) on oral lichen planus (OLP) that have been reported in the literature during the past decades. Although the presently available DSSs may all have some merit, particularly for research purposes, the diversity

  18. A retrospective study of oral lichen planus in paediatric population

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    Kabita Chatterjee

    2012-01-01

    Full Text Available Aim: Well documented cases of oral lichen planus, a cell mediated immune condition is infrequently reported in paediatric population. This study was undertaken to obtain epidemiological data retrospectively and also to explore the possibility of any association that might exist among the clinical and histopathological features in paediatric patients suffering from oral lichen planus. Subjects and Methods: A retrospective study was carried out on 22 patients, younger than 18 years with clinical and histopathological diagnosis of oral lichen planus over a period of 14 years. The clinical characteristics and histopathological features were observed. The statistical analysis of the data was performed using Statistical Analysis Software (SAS, Version 9.1. Results: Analysis of data of 22 patients revealed that the average age of patient is 15.18 years with equal male and female predilection. The most common site is buccal mucosa (50% and most frequent clinical form is erosive (63.64%. Focusing on the histopathological findings, parakeratosis was found in 86.36% of the cases, acanthosis in 63.64% of cases, moderate basal cell degeneration was identified in 63.64% of cases and dense lymphocytic infiltration at juxtaepithelial connective tissue region was found in 59.09% of cases. Conclusions: Oral lichen planus in paediatric population is rare and appeared between 8 to 18 years of age. There is no significant gender predominance. The most common clinical form is erosive, manifesting mainly in buccal mucosa. Histopathological findings characteristic of oral lichen planus in paediatric patients include parakeratosis, acanthosis, liquefaction degeneration of basal cells and lymphocytic infiltration in the subepithelial layer.

  19. Effect of Aaloe vera Gel Versus Local triamcinolone in Treatment of Oral Lichen Planus

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    Amanat D.

    2011-02-01

    Full Text Available Statement of Problem: Oral lichen planus (OLP is a chronic inflammatory disorder which can specially be painful in atrophic, erosive and ulcerative forms. In this area, different treatment plans with different results have been evaluated Purpose: The aim of this article is to compare the effect of aloe vera gel and local triamcinolone in treatment of oral lichen planus lesions.Materials and Method: In this double blind research, 50 patients (13 males and 37 females having oral lichen planus lesions were selected and randomly divided into two groups. The first group received 70% aloe vera gel and the second group, 0.1% local triamcinolone. Both groups used the drug locally 3 times a day for 8 weeks. All the patients were under follow up every 2 weeks. Clinical evaluation and pain reduction was evaluated by Thongprasom and VAS methods in both groups. Data were evaluated by repeated measure technique.Results: 20 patients of the triamcinolone group showed good response to treatment and 3 patients had complete remission during the treatment period. In aloe vera group, 9 patients had good response and no one showed complete remission ( p <0.001. No significant lesion was seen in both groups during the treatment period Conclusion: Application of aloe vera gel is suggested in treatment of erosive and atrophic lichen planus lesions in comparison with steroids. However, according to the results of this study, the use of steroid instead of aloe vera in treating ulcerative lichen planus lesions is a better and more appropriate choice.

  20. Meteorological influences on the incidence of lichen planus in a north Indian population.

    Science.gov (United States)

    Prakash S Mohan, Ravi; Ghanta, Soumi; Verma, Sankalp; Agarwal, Neha; Gupta, Nupur; Singh, Udita

    2013-01-01

    Lichen planus is a chronic, autoimmune, mucocutaneous disease that shows differences in clinical presentation at different times of the year. The present retrospective study was conducted to clarify the meteorological factors that influence the incidence of lichen planus, as well as the general features and clinical presentation of this condition during three consecutive years, 2008, 2009, and 2010, in Moradabad district (Western Uttar Pradesh, India). The study group comprised 1,355 patients extracted from the records of the outpatient department of Kothiwal Dental College Research Centre and Hospital, who were clinically diagnosed as having lichen planus during this three-year period. The highest number of patients (735) were recorded in summer, and the lowest (56) in winter. Females were affected more often, and psychosocial influences were also evident. There were significant differences in the incidence of lichen planus in different seasons, and the summer peak was attributable to the intensity of sun exposure (actinic lichen planus and summertime lichen planus).

  1. Evaluation of clinical parameters related to methotrexate therapy in lichen planus

    OpenAIRE

    Samaresh Chandra Hazra; Agha Masood Choudhury; Lubna Khondker; Md. Shirajul Islam Khan; Muhammad Munir Rashid

    2016-01-01

    Background: For better management of lichen planus a clinical trial of oral methotrexate is necessary in ow· country. Objective: The objective of this study is to evaluate efficacy and safety ofmethotrexate therapy in the treatment of lichen planus.Methods: It was a prospective randomized controlled clinical trial conducted in the department of Dermatology and Venereology, BSMMU, Dhaka, from January 2009 to December 2010. Forty four patients of lichen planus were included in the study. Cases ...

  2. Heterogeneous disease: a child case of lichen planus pemphigoides triggered by varicella.

    Science.gov (United States)

    İlknur, Turna; Akarsu, Sevgi; Uzun, Soner; Özer, Erdener; Fetil, Emel

    2011-07-01

    Lichen planus pemphigoides (LPP) is a rare and controversial disease. It is characterized clinically by tense bullae arising both on lichen planus papules and on uninvolved skin, histologically by the demonstration of subepidermal bullae and by linear deposits of immunoglobulin G and C3 along the basement membrane zone on immunofluorescence of peribullous skin. Some authors consider LPP as the combination of lichen planus and bullous pemphigoid. Others think that it most likely encompasses a heterogeneous group of subepidermal autoimmune blistering disorders occurring in association with lichen planus. We present a child case that supports the heterogeneous condition of this disease triggered by varicella.

  3. The comparative analysis of dermatoscopy picture of lichen planus and psoriasis

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    Sherstobitova K.Yu.

    2016-09-01

    Full Text Available Aim: analysis of different dermatoscopic patterns of lichen planus and psoriasis. Material and methods. We observed 80 patients: 40 with psoriasis, 40 — with lichen planus. Dermatoscopic study was conducted using video-dermatoscope of expert class "MoleMaxHD" (Derma Medical Systems company, Austria, under magnification from хЗО to x80. Results. Comparing the dermotoscopic findings of psoriatic plaque and lichen planus, vascular features were found to be more significant in psoriasis and in lichen planus non-vascular features were more prominant. Conclusion. Dermoscopy can be successfully used in differential diagnosis of these dermatoses.

  4. Investigating Immunohistochemical Expression of cyclooxygenase-2 in oral lichen planus

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    Maryam Seyedmajidi

    2016-06-01

    Full Text Available Background and goal: (cox2 Cyclooxygenase -2 as an enzyme is not present in normal tissues and in fact is a type of inductive enzyme during pathological phenomena such as inflammation and cancer are significantly increased. Increased expression of cox-2 in gastric carcinoma, pancreatic, lung and oral squamous cell carcinoma has been shown and seems to be one of the performance mechanisms of the inhibition of apoptosis in tumor cells. Regarding the role of cox-2 in apoptosis mechanisms and the creation of dysplastic changes and malignant, the study aimed to evaluate the immunohistochemical expression of cox-2 in oral lichen planus and were compared with normal mucosa and gingivitis. Methods: The study was performed on 30 paraffin blocks related to patients referred to oral and maxillofacial pathology department in Dental School of Babol with confirmed diagnosis of oral lichen planus was done. The same number of samples of normal mucosa and samples of gingivitis were studied. Slices prepared from the above blocks bycoloring immunostaining cox-2 were stained and after reviewing the slides obtained, data using statistical software spss20 and x2 tests, Mann-Whitney and parametric tests such as T test was analyzed and P ˂0.05 was considered significant Results: In this study, significantly percentage of stained cells and staining intensity of cells in the basal layer of lichen planus was higher than normal mucosa (p <0.001. In parabasal layer the results were similar (p <0.001. This results in comparison to lichen planus and gingivitis in basal layer (p <0.001 and parabasal was seen (p <10.0. On the other hand, significantly the percentage of stained cells and staining intensity of cells in the basal layer of gingivitis was more than normal mucosa (p <0.001. In above comparison, similar result in the parabasal layer was seen (p <0.001. The percentage of stained cells and staining intensity of cells in lymphocytic infiltration was significantly higher

  5. Squamous cell carcinoma of the tongue arising in lichen planus: a case report and review of the literature.

    Science.gov (United States)

    Camisa, C; Hamaty, F G; Gay, J D

    1998-10-01

    Lichen planus is a relatively common inflammatory disorder of unknown cause that affects the skin and mucosal surfaces. The relationship of oral lichen planus to oral squamous cell carcinoma is a matter of concern and debate. We present a case of squamous cell carcinoma of the dorsal surface of the tongue that arose in a previously biopsy-confirmed area of lichen planus. The literature on the development of oral cancer in patients with lichen planus is reviewed.

  6. Lichen planus of the lower limbs: successful treatment with psoralen cream plus ultraviolet A photochemotherapy.

    Science.gov (United States)

    Alsenaid, Adel; Alamri, Ali; Prinz, Jörg C; Ruzicka, Thomas; Wolf, Ronald

    2016-01-01

    Lichen planus (LP) classifies into different subtypes depending on morphology and localization. Localized LP of the lower limb (LPLL) manifests a great challenge due to persistent itching, therapeutic resistance and the risk to develop into SCC. We report two cases with LPLL refractory to standard topical therapy, which were successfully treated with psoralen cream plus UVA photochemotherapy (cream-PUVA). We propose cream-PUVA as an alternative therapeutic option effective for localized LP of the lower limbs.

  7. Atypical case of lichen planus recognized by dermoscopy

    Science.gov (United States)

    Papageorgiou, Chrysoula; Apalla, Zoe; Lazaridou, Elizabeth; Sotiriou, Elena; Vakirlis, Efstratios; Ioannides, Demetrios; Lallas, Aimilios

    2016-01-01

    Lichen planus (LP) is an inflammatory disease that affects the skin—mainly the extremities and the trunk—the mucous membranes, the genitalia, the nails and the scalp. The diagnosis of LP is usually established clinically based on the typical morphology and distribution of the lesions in conjunction with the associated itch. We report a patient with LP manifesting highly psoriasiform lesions, that could only be correctly assessed after the application of dermoscopy, which revealed LP-specific findings. PMID:27867746

  8. Childhood Oral Lichen Planus: Report of Two Cases.

    Science.gov (United States)

    George, Sageena; John, Sheen Ann; Anandaraj, S; Issac, Jyoti Sumi; Harris, Anoop; Reshmi, J

    2015-05-01

    Lichen planus (LP) is a chronic mucocutaneous disease widely recognized in adults, but uncommon in children. The purpose of this paper is to report two cases of LP in children. The diagnosis was made based on clinical and histopathological findings. The treatment consisted of antifungal and multivitamin therapy. Regression of lesions was observed. The patients are still under follow-up. Although LP is uncommon in children, it is necessary to have adequate knowledge about this condition for proper diagnosis and treatment.

  9. Role of angiogenesis in the pathogenesis of oral lichen planus

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    Nitasha Mittal

    2012-01-01

    Full Text Available Background: The etiology of oral lichen planus (OLP is not fully understood. It is generally considered to be a T-cell mediated chronic inflammatory oral mucosal disease. There is increasing evidence that chronic inflammation is linked to the diseases associated with endothelial dysfunction and is involved in the induction of aberrant angiogenesis. Aim: Our aim was to evaluate the role of angiogenesis in the pathogenesis of OLP by immunohistochemistry, using the CD34 antibody. Materials and Methods: Forty tissue sections (7 of erosive lichen planus, 18 of reticular oral lichen planus, and 15 of normal oral mucosa, were assessed for microvessel density (MVD in five selected areas of high inflammatory infiltrate by immunohistochemistry for the expression of CD34 antibody. Results and Conclusion: The mean MVD was 44.47 in the control group (normal oral mucosa and 97.24 in the OLP group, showing that there is increased angiogenesis in the latter. Reticular OLP had mean MVD of 84.61 and erosive OLP had mean MVD of 129.71, showing relatively greater angiogenesis in erosive OLP as compared to reticular OLP. Thus, angiogenesis can be considered to play a role in both the etiopathogenesis and the progression of OLP.

  10. Lichen planus follicularis:a case report%毛囊性扁平苔藓1例

    Institute of Scientific and Technical Information of China (English)

    严红霞; 史冬梅; 弓娟琴

    2015-01-01

    毛囊性扁平苔藓是扁平苔藓的一种少见类型,本文报道1例。患者,男,49岁。腰腹部及四肢米粒大淡褐色、红色丘疹10个月。组织病理检查符合扁平苔藓。外用糖皮质激素等治疗,皮损渐好转。%Lichen planus follicularis is a rare type of lichen planus and we reported a patient. A 49-year-old male presented with brown papules and red maculopapules on waist, abdomen and limbs for 10 months. The pathological feature of the lesion was accordance with the diagnosis of lichen planus follicularis. The pa-tient was treated with local glucocorticoid and the lesion was gradually improved.

  11. Oral lichen planus and oral lichenoid lesions; a critical appraisal with emphasis on the diagnostic aspects

    NARCIS (Netherlands)

    van der Waal, I.

    2009-01-01

    Oral lichen planus (OLP) has a prevalence of approximately 1%. The etiopathogenesis is poorly understood. The annual malignant transformation is less than 0.5%. There are no effective means to either predict or to prevent such event. Oral lesions may occur that to some extent look like lichen planus

  12. Prevalence of oral lichen planus in HCV infected patients: the effective factors

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    Khatibi M

    2008-11-01

    Full Text Available "nBackground: Hepatitis C is a major cause of chronic liver disease and hepatocellular carcinoma. Hepatitis C infection also has extrahepatic manifestations, including cryoglobulinemia and lichen planus. Lichen planus is a relatively common mucocutaneous disorder, and, due to its chronic pattern and increased incidence of malignancy, diagnosis and treatment of this disease are very important. The aim of the present study was to investigate the prevalence of oral lichen planus in HCV-infected patients. "nMethods: In this cross sectional- descriptive study, the prevalence of oral lichen planus was evaluated by means of observation, clinical examination, questionnaire and evaluation of the medical records of 150 patients referred to the hepatitis clinic, gastrointentrology and infectious disease wards of Imam Khomeini Hospital and the Iran Blood Transfusion Organization, Tehran, Iran. We used a sequential method for sampling. Data were analyzed using statistical software (SPSS ver. 11 and the chi-square test. "nResults: From a total 150 patients, 133 were male and 17 female. Six cases (4% had oral lichen planus. All patients with oral lichen planus were male and the buccal mucosa was the most common site. "nConclusions: According to this study, the prevalence of oral lichen planus in patients afflicted with HCV is higher than in the normal population. We should pay more attention to oral lichen planus as one of the extrahepatic manifestations of hepatitis C.

  13. A Quantitative Evaluation Of Epithelium And Inflammatory Infiltrate Of Lichen Planus And Lichenoid Reactions

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    Maji Jose

    2012-07-01

    Full Text Available Lichen planus and Lichenoid reaction are two different entities that pose adiagnostic dilemma. Objectives: Lichen planus and Lichenoid reactions are clinically andhistopathologically very similar but have different treatment and prognosis. This particularstudy is aimed at differentiating both these entities histopathologically with the use ofmicrometry and to find the role of subepithelial chronic inflammatory infiltrate onoverlying epithelium with regard to its thickness.Methods: In the present study, Lichen Planus (n=30 and Lichenoid reactions (n=10 werestudied. Using eyepiece graticule, epithelial thickness and subepithelial inflammatory bandthickness were measured in these lesions.Results: Positive correlation was seen between epithelial and inflammatory band thicknessin cases of lichenoid reactions and a negative correlation in cases of lichen planus.Conclusion: The study suggests that the nature and thickness of subepithelial infiltrate hasan influence on the overlying epithelium in Lichen Planus and Lichenoid reaction.

  14. Severe Gingival Enlargement with Coexisting Erosive Lichen Planus in Severe Chronic Periodontitis Patient

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    Ambika Sharma

    2015-01-01

    Full Text Available Plaque induced gingival enlargement is most commonly seen and when encountered simultaneously with erosive lichen planus poses a challenge to the treating dentist. Prognosis of one condition may influence the prognosis of another condition. The presented case highlights the significance of proper diagnosis and the management of simultaneously occurring gingival lesions. A 49-year-old hypertensive female presented with painful enlarged bleeding and suppurating gums with burning sensation on eating food along with long-term usage of antihypertensive drug amlodipine known for its gingival enlargement effect. All these multiple factors led to diagnostic dilemma. Effective management of the gingival enlargement was done by using electrocautery to rehabilitate the functions and esthetics of the patient. Gingival condition was also complicated by the presence of coexisting lichen planus which was predominantly erosive for which topical corticosteroid, antifungal, and antimicrobial agents were prescribed. Eight-month follow-up did not show recurrence of gingival enlargement. Electrocautery is an effective tool for the gingivectomy in severe inflammatory type of gingival enlargement because of rapid postoperative hemostasis. For the management of erosive lichen planus, long-term use of topical corticosteroids is an effective approach. Maintenance of oral hygiene and regular follow-ups are essential for these conditions.

  15. Lichen planus and other lichenoid dermatoses: Kids are not just little people.

    Science.gov (United States)

    Payette, Michael J; Weston, Gillian; Humphrey, Stephen; Yu, JiaDe; Holland, Kristen E

    2015-01-01

    Lichenoid dermatoses, a group of inflammatory skin conditions with characteristic clinical and histopathologic findings, range from common to rare. Classic lichen planus typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques; many variants in morphology and location also exist. Other lichenoid dermatoses share similar clinical presentations and histopathologic findings. These include lichenoid drug eruption, lichen planus-like keratosis, lichen striatus, lichen nitidus, and keratosis lichenoides chronica. Epidemiologic characteristics vary among each lichenoid disorder. While classic lichen planus is considered a disease of adults, other lichenoid dermatoses may be more common in younger populations. The literature contains an array of reports on the variations in presentation and successful management of lichen planus and lichenoid dermatoses among diverse populations. Familiarity with the characteristics of each lichenoid dermatosis, rare or common within each patient population, is key to accomplishing timely recognition and effective management.

  16. Facial follicular cysts: a case of lichen planus follicularis tumidus?

    Science.gov (United States)

    Jiménez-Gallo, David; Albarrán-Planelles, Cristina; Linares-Barrios, Mario; Martínez-Rodríguez, Alberto; Báez-Perea, José María; González-Fernández, Julio Abraham

    2013-09-01

    Lichen planus follicularis tumidus (LPFT) represents an uncommon variety of lichen planus (LP). Clinically, it presents with prominent purplish lesions or white-pigmented yellowish cysts and comedones. Histopathologically, it is similar to lichen planopilaris, and it is additionally characterized by follicles and cysts surrounded by a lichenoid lymphocytic infiltrate. The most common location is the retroauricular region, and it may be associated with other variants of LP. Herein, we describe the case of a 50-year-old woman with a history of lower limb hypertrophic LP who subsequently presented with multiple pink, tumid, pruritic plaques with white-yellow cysts and comedones extensively affecting the bilateral face. Histopathologic examination revealed a lichenoid infiltrate surrounding the follicles and cysts. We diagnosed LPFT and began treatment with topical corticosteroids, antihistamines, systemic corticosteroids and oral acitretin without improvement. Subsequently, the patient had an acceptable response to cyclosporine at doses of 5 mg/kg/day with remission of itching and tumidity but with residual cysts and comedones remaining. To date, the literature contains only 16 cases of LPFT. To our knowledge, this is the most severe case and is the only one with cessation of disease activity in response to cyclosporine.

  17. Frequency of Genital Involvement in Women with Oral Lichen Planus in Southern Iran

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    M. Davarmanesh

    2012-01-01

    Full Text Available Background. Lichen Planus is a chronic mucocutaneous disease of immunological basis and unknown etiology. women with oral lichen planus may have concomitant manifestations in vulvovaginal areas. Objective. To determine the frequency and risk factors of genital involvement in a group of Iranian women affected by oral lichen planus. Methods. Thirty-six women with clinical and histopathological diagnosis of oral lichen planus were evaluated for demographic, historical, and clinical parameters of the oral disease. All the patients were referred for careful vulvovaginal examination, as well as histopathological assessment upon clinical indication. Results. Nineteen patients complained from genital symptoms but the number of women with the final diagnosis of genital lichen planus (=2 was too small to show any correlation with the parameters evaluated. Conclusion. In spite of low genital involvement possibly due to inadequate patient population, lack of follow-up visits, and contribution of genetic or ethnic factors, for conservative patient care, women with the oral lichen planus in particular those having some relevant genital symptoms, should preferably be referred for careful vulvovaginal examination. Multicenter cohort studies on women of different geographical regions or ethnicities who have genital lichen planus alone or in combination with other common sites are encouraged.

  18. Human papilloma virus as a possible factor in the pathogenesis of oral lichen planus

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    Sayed Mohammad Razavi

    2009-01-01

    Full Text Available Background: Oral lichen planus (OLP is a common chronic inflammatory mucocutaneous disease. Clinical diagnosis of OLP requires clinical work-up and histologic examination to rule out possible dysplasia and carcinoma. It is possible that oral mucosal viral infections including HPV infection may have a causative role in OLP pathogenesis. The aim of this study was to examine the co-incidence of human papilloma virus type 18 and oral lichen planus. Methods: This study was a case-control study. Twenty nine paraffinized specimens of previously diagnosed oral lichen planus and 14 paraffinized specimens of nonpathogenic mucosa were studied. Polymerase Chain Reaction ( PCR analyze used for detection of DNA HPV 18 .The data were ana-lyzed with SPSS software and Fisher′s exact test was used to find the possible relation between HPV18 infection and oral lichen planus. Results: Nine out of 29 (31.0% lichen planus samples and one out of 14 (7.1% controls were HPV 18 positive. No significant correlation (P = 0.128 was observed between HPV18 infection and oral lichen planus. Conclusion: According to the findings there might be a coincidence of human papilloma virus type 18 and oral lichen planus.

  19. Oral lichen planus: a literature review and update.

    Science.gov (United States)

    Alrashdan, Mohammad S; Cirillo, Nicola; McCullough, Michael

    2016-10-01

    Lichen planus (LP) is a common chronic inflammatory condition that can affect skin and mucous membranes, including the oral mucosa. Because of the anatomic, physiologic and functional peculiarities of the oral cavity, the oral variant of LP (OLP) requires specific evaluations in terms of diagnosis and management. In this comprehensive review, we discuss the current developments in the understanding of the etiopathogenesis, clinical-pathologic presentation, and treatment of OLP, and provide follow-up recommendations informed by recent data on the malignant potential of the disease as well as health economics evaluations.

  20. Childhood Oral Lichen Planus: Report of Two Cases

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    Sageena George

    2015-10-01

    Full Text Available Lichen planus (LP is a chronic mucocutaneous disease widely recognized in adults, but uncommon in children. The purpose of this paper is to report two cases of LP in children. The diagnosis was made based on clinical and histopathological findings. The treatment consisted of antifungal and multivitamin therapy. Regression of lesions was observed. The patients are still under follow up.Although LP is uncommon in children, it is necessary to have adequate knowledge about this condition for proper diagnosis and treatment.

  1. Smoking Habits Among Patients Diagnosed with Oral Lichen Planus

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    Hasson-Kanfi Haya

    2004-06-01

    Full Text Available Abstract Introduction Oral lichen planus (OLP is one of the most common dermatologic diseases that manifests in the oral cavity. The purpose of this study was to evaluate the association between smoking habits and the clinical subtypes of OLP. Methods Oral findings and smoking data from 187 charts of OLP patients from an oral medicine clinic was reviewed and compared to data from 76 matched control patients. Results and Discussion Ninety-three patients were diagnosed with reticular OLP, 55 with atrophic and 39 with erosive forms of the disease. Symptomatic OLP occurred in 63.6% of patients. Fewer cases of reticular OLP were symptomatic than erosive OLP (p

  2. The Relationship between Anger Expression and Its Indices and Oral Lichen Planus.

    Science.gov (United States)

    Mehdipour, Masoumeh; Taghavi Zenouz, Ali; Farnam, Alireza; Attaran, Rana; Farhang, Sara; Safarnavadeh, Maryam; Gholizadeh, Narges; Azari-Marhabi, Saranaz

    2016-05-01

    Oral lichen planus (OLP) is a common inflammatory disease with unknown etiology. Depression, stress and anxiety are psychological factors that their influence on the expression of lichen planus by affecting the immune system's function has been confirmed. There is a probable relationship between anger and OLP expression. Therefore, the present study aimed to evaluate the association of "anger" and OLP. In this descriptive study 95 subjects were included in 3 groups. A: patients with oral lichen planus, B: positive control, C: negative control. Anger and its indices were assessed by the State-Trait Anger Expression Inventory-2 (STAXI-2) questionnaire, and pain was measured via the Visual Analogue Scale (VAS). The collected data were analyzed statistically using SPSS 18 software. The lichen planus and positive control groups bore higher total anger index (AX index) values compared with the negative control. Comparing anger expression-in (AXI) among the lichen planus and negative control groups revealed higher grades in lichen planus group. Evaluating the pain severity index (VAS) data and anger indices in lichen planus group, Spearman's Rank Correlation Test revealed a significant correlation between TAngR (reactional anger traits) and pain severity. The findings of this study indicated that there was a significant correlation between anger control and suppression of lichen planus development. On the other hand, the patients with more severe pain mostly expressed their anger physically. Based on the findings, we can make the claim that anger suppression and its control-in (gathering tension) may play a role in the development of lichen planus as a known psychosomatic disorders.

  3. Psychiatric morbidity in oral lichen planus: A preliminary study

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    Abhishek Ranjan Pati

    2014-01-01

    Full Text Available Objective: To study the clinical types and association of psychological factors in patients with Oral Lichen Planus (OLP. Materials and Methods: An analytical age- and sex-matched study involved 30 patients with oral lichen planus (group 1 and 30 control subjects (group 2. We applied the following psychometric tests to both groups: General Health Questionnaire (GHQ and Hospital Anxiety and Depression Scale (HADS. Results: The patients with OLP were found to exhibit statistically significant higher anxiety, insomnia, and social dysfunction with the tests that were used (GHQ 24 and HADS than the control group (P > 0.05. The study group likewise exhibited greater depression and somatic symptoms. The mean total of the GHQ and HAD scores were found to be higher in the study group than in the controls (P > 0.05. Among the various types of OLP, patients with the erosive type had higher mean scores for anxiety and insomnia, social dysfunction and depression. Conclusion: In most patients psychiatric morbidity was strongly associated with OLP, which could support its role in the etiopathogenesis of the disease. The higher scores of the General Health Questionnaire and Hospital Anxiety and Depression Scale gave an insight into the hypothesis that psychological factors are associated with the causation of OLP.

  4. Oral lichen planus: A look from diagnosis to treatment.

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    Pablo Córdova

    2014-03-01

    Full Text Available Oral lichen planus (OLP is a chronic mucocutaneous disease of unknown etiology. Its pathogenesis is multifactorial and it may affect the oral mucosa, skin and other mucous membranes. Diagnosis is based on clinic and histopathology; direct immunofluorescence techniques can also be of use. It affects about one to two percent of the population, mainly women between the fifth and sixth decades of life. In the mouth, the most affected area is the buccal mucosa, followed by the gums, tongue and/or palate. Its three most representative clinical forms are reticular, erythematous and erosive; evolution depends on the type it is. Lesion treatment is determined by the clinical form and, since no fully effective treatment has been found yet, it is directed towards controlling the disease. The treatment of choice involves topical or systemic corticosteroids, but other drugs may also be used.The aim of this paper is to gather current and relevant information about oral lichen planus: its pathogenesis, diagnosis, treatment and management.

  5. Evaluation of Hepatitis B Vaccination among Lichen Planus Patients.

    Science.gov (United States)

    Balighi, K; Daneshpazhooh, M; Nasimi, M; Loloee, S; Asadi, A; Azizpour, A

    2016-07-01

    Lichen planus (LP) is an idiopathic chronic inflammatory mucocutaneous disease. Many reports in the literature have described hepatitis B vaccine as a predisposing factor for LP. This study was performed to determine the rate of previous vaccination against hepatitis B in LP patients. This was a cross sectional study on LP patients. Diagnosis of LP was confirmed by histological examination. Data were gathered by dermatology residents based on a checklist designed to guide their interview. Blood samples were tested for HBsAB titer, HBsAg, HCV Ab and liver function tests. One hundred & twenty four (124) patients entered the study. Females were 2.72 times more affected. The mean age of patients was 45.63 years (age range; 18-88). Forty-four (35.5%) patients had been vaccinated against hepatitis B. Lichen planus during the first six months of vaccination occurred in only one patient. Our findings bring into question the causative role of HBV vaccine in LP incidence in our population.

  6. Salivary levels of tumor necrosis factor-α in oral lichen planus

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    Sonja Pezelj-Ribaric

    2004-01-01

    Full Text Available OBJECTIVE: Oral lichen planus (OLP is chronic inflammatory disease of the oral mucosa, presenting in various clinical forms. The etiology of OLP is still unknown but mounting evidence points to the immunologic basis of this disorder.

  7. Early Onset Squamous Cell Carcinoma In A Case Of Lichen Planus

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    Singh Shri Nath

    1998-01-01

    Full Text Available Lichen planus, which is a very common condition, is being presented. However, the uncommon feature in this cases is its early onset and equally early development of squamous cell carcinoma on a lesion on the right thigh.

  8. Expression of TLR9 and Its mRNA in the Lesions of Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    LI Jiawen; CHEN Jing; TAN Zhijian; LIU Houjun; LIU Zhixiang

    2007-01-01

    To investigate the role of toll-like receptor 9 (TLR9) in the pathogenesis of lichen planus,the expressions of TLR9 and its mRNA in the lesional skin of lichen planus were detected by immunohistochemical technique (SP) and RT-PCR. As control, normal skin of healthy volunteers was also tested. The immunohistochemical study showed that the expression of TLR9 in the lesional skin of lichen planus was significantly higher than that in the normal controls. The results of RT-PCR showed that both skin lesions and normal controls had TLR9 expression. In skin lesions, the expression level of TLR9 mRNA was 1.6075±0.0930, which was significantly higher than that in normal controls (P<0.001). These findings indicated that up-regulated expression of TLR9 and its mRNA might be involved in the pathogenesis of lichen planus.

  9. [Oral medicine 9. Lichen planus and lichenoid lesions of the oral mucosa].

    Science.gov (United States)

    van der Meij, E H; Schepman, K P; de Visscher, J G A M

    2013-09-01

    The general dentist is sometimes confronted with white lesions of the oral mucosa. Oral lichen planus is the most common oral white lesion. The diagnosis can usually be made on the basis of the clinical aspect, but is sometimes made more difficult by certain abnormalities in the oral mucosa which clinically resemble oral lichen planus or by abnormalities which cannot be distinguished from oral lichen planus but have a different origin. Those lesions are classified as oral lichenoid lesions. Malignant deterioration has been described in allforms of oral lichen planus lesions and oral lichenoid lesions. There is no known method to predict or prevent malignant transformation. Nor are there any studies examining the efficacy of frequent follow-up visits. It seems sensible, in keeping with the tendency in recent literature, to schedule annual check-ups for patients to be on the safe side. These follow-up visits may reasonably be performed in a general dental practice.

  10. Comparing clinical effects of photodynamic therapy as a novel method with topical corticosteroid for treatment of Oral Lichen Planus.

    Science.gov (United States)

    Bakhtiari, Sedigheh; Mojahedi, Seyyed Masoud; Azari-Marhabi, Saranaz; Namdari, Mahshid; Rankohi, Zahra Elmi

    2017-06-29

    Oral lichen planus is an autoimmune disorder with several challenges in treatment. Photodynamic therapy has been proposed as a new treatment option for the disease. The present study compared the clinical effects of the photodynamic therapy and dexamethasone mouthwash in the treatment of oral lichen planus lesions. In this randomized clinical trial, 30 patients with oral lichen planus were included.15 patients were treated with 5% methylene blue mediated photodynamic therapy using Fotosan device for 30seconds (630nm wavelength and 7.2-14.4J/CM2 dose) for 4 sessions in the days 1,4,7,14. In another group, the treatment was done on 15 patients by 0.5mg tab dexamethasone solution in 5cc water, rinsed 4 times in a day within two weeks. The sign score, symptoms scores (pain), clinical severity and treatment efficacy were measured at the days 15,30,60,90 after beginning of the treatment. The results were subjected to Mann-whitney U test in both groups. No significant difference existed between two modalities regarding the treatment efficacy index, sign score, symptom score and clinical severity on the 15, 30, 60 and 90 post-treatment days. Decreases in patient's symptoms were statistically significant in both groups. Photodynamic therapy was as effective as the dexamethasone mouth wash in the treatment of oral lichen planus It could be used as a safe modality in the treatment of oral lichen planus lesions without identified side effects. Copyright © 2017. Published by Elsevier B.V.

  11. Lichen planus pigmentosus in linear and zosteriform pattern along the lines of Blaschko.

    Science.gov (United States)

    Vineet, Relhan; Sumit, Sethi; K, Garg Vijay; Nita, Khurana

    2015-10-16

    Lichen planus pigmentosus (LPP) is a variant of lichen planus (LP) reported in various ethnic groups. It occurs predominantly in the third or fourth decade of life and is characterized by the insidious onset of dark-brown macules in sun exposed areas and flexural folds. Rarely, has it been described in a linear or segmental distribution. Herein we describe a case of LPP with lesions lateralized to right side of body along the lines of Blaschko, in a linear and zosteriform pattern.

  12. Lichen planus pigmentosus-inversus: report of three Chinese cases and review of the published work.

    Science.gov (United States)

    Chen, Shumin; Sun, Wenqi; Zhou, Guizhi; Chen, Shengli; Lu, Xuanmei

    2015-01-01

    Lichen planus pigmentosus-inversus is a rare variant of lichen planus. So far, only 24 cases from 12 reports have been documented in the published work. The prominent characteristics of the disease are dark-brown macules and patches confined to the non-sun exposed, flexural areas and skin folds with lichenoid pathological changes and prominent melanin incontinence. We report three female Chinese patients with typical clinical and pathological manifestations and a miniature review of the published work.

  13. Salivary Total Antioxidant Capacity and Lipid Peroxidation in Patients with Erosive Oral Lichen Planus

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    Atena Shirzad

    2014-03-01

    Full Text Available Background and aims. Oral lichen planus is a common chronic inflammatory disease of the oral mucosa with malignant potential, pathogenesis of which is not still well known. Free radicals and reactive oxygen species can play an important role in the pathogenesis of oral lichen planus. The aim of this study was to investigate salivary oxidative stress and antioxidant systems in patients with oral lichen planus. Materials and methods. In this case-control study, 30 patients with oral lichen planus (case group and 30 age- and gender-matched healthy subjects (control group, referring to Dental School of Babol University of Medical Sciences, were selected using simple sampling method. Unstimulated saliva of the two groups was collected. Salivary total antioxidant capacity (TAC and lipid peroxidation products were investigated and compared, using ferric reducing antioxidant power (FRAP and thiobarbituric acid reactive substance (TBARS methods, respectively. Data were analyzed using Student’s ttest. Results. The mean and standard deviation of salivary TAC in patients with oral lichen planus (297.23 ± 149.72 μM was significantly lower than that in the controls (791.43±183.95 μM; P < 0.0001, and mean and standard deviation of salivary malondialdehyde (MDA (0.49 ± 0.30 μM was remarkably higher in oral lichen planus patients compared to the control group (0.15 ± 0.11 μM (P < 0.0001. TAC was also reduced in both groups in line with an increase in the level of MDA (P < 0.0001, r = −0.48. Conclusion. The results of this study suggested that an increase in oxidative stress and an imbalance in antioxidant defense system in the saliva of oral lichen planus patients may be involved in the pathogenesis of oral lichen planus.

  14. Salivary total antioxidant capacity and lipid peroxidation in patients with erosive oral lichen planus.

    Science.gov (United States)

    Shirzad, Atena; Pouramir, Mahdi; Seyedmajidi, Maryam; Jenabian, Niloofar; Bijani, Ali; Motallebnejad, Mina

    2014-01-01

    Background and aims. Oral lichen planus is a common chronic inflammatory disease of the oral mucosa with malignant potential, pathogenesis of which is not still well known. Free radicals and reactive oxygen species can play an important role in the pathogenesis of oral lichen planus. The aim of this study was to investigate salivary oxidative stress and antioxidant systems in patients with oral lichen planus. Materials and methods. In this case-control study, 30 patients with oral lichen planus (case group) and 30 age-and gender-matched healthy subjects (control group), referring to Dental School of Babol University of Medical Sciences, were selected using simple sampling method. Unstimulated saliva of the two groups was collected. Salivary total antioxidant capacity (TAC) and lipid peroxidation products were investigated and compared, using ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substance (TBARS) methods, respectively. Data were analyzed using Student' t-test. Results. The mean and standard deviation of salivary TAC in patients with oral lichen planus (297.23 ± 149.72 μM) was significantly lower than that in the controls (791.43 ± 183.95 μM; P & 0.0001), and mean and standard deviation of salivary malondialdehyde (MDA) (0.49 ± 0.30 μM) was remarkably higher in oral lichen planus patients compared to the control group (0.15 ± 0.11 μM) (P & 0.0001). TAC was also reduced in both groups in line with an increase in the level of MDA (P & 0.0001, r = -0.48). Conclusion. The results of this study suggested that an increase in oxidative stress and an imbalance in antioxidant defense system in the saliva of oral lichen planus patients may be involved in the pathogenesis of oral lichen planus.

  15. Evaluation of oxidative stress in oral lichen planus using malonaldehyde: A systematic review

    Directory of Open Access Journals (Sweden)

    Shovna Shivani Mishra

    2014-01-01

    Conclusion: This review reveals only 8 studies that demonstrate the elevated oxidative stress levels in oral lichen planus using malonaldehyde as a biomarker. Therefore, further studies need to be performed which would estimate the levels of MDA in serum, saliva and tissue samples of the same group of patients with oral lichen planus, so as to draw definitive conclusions and significant correlation between the MDA levels from the three samples.

  16. Human Papilloma Virus as a Possible Factor in the Pathogenesis of Oral Lichen Planus

    OpenAIRE

    Sayed Mohammad Razavi; Parichehr Ghalayani; Mohammad Reza Salehi; Hajar Attarzadeh; Mahdi Shahmoradi

    2009-01-01

    Background: Oral lichen planus (OLP) is a common chronic inflammatory mucocutaneous disease. Clinical diagnosis of OLP requires clinical work-up and histologic examination to rule out possible dysplasia and carcinoma. It is possible that oral mucosal viral infections including HPV infection may have a causative role in OLP pathogenesis. The aim of this study was to examine the co-incidence of human papilloma virus type 18 and oral lichen planus. Methods: This study was a case-control stud...

  17. A case of lichen planus pigmentosus that was recalcitrant to topical treatment responding to pigment laser treatment.

    Science.gov (United States)

    Han, Xiuhui Debra; Goh, Chee Leok

    2014-01-01

    Lichen planus pigmentosus is a rare variant of lichen planus for which no effective treatment is currently available. Patients usually present with hyperpigmented, dark brown macules on sun-exposed areas or flexural folds. Here we describe a 50-year-old Chinese woman who had biopsy-confirmed lichen planus pigmentosus that was recalcitrant to a variety of topical treatments, but responded to treatment with a pigment laser.

  18. Lichen planus of uterine cervix - the first report of a novel site of occurrence: a case report

    OpenAIRE

    Gupta, Ruchika; Bansal, Bhavna; Singh, Sompal; Yadav, Indra; Gupta, Kusum; Kudesia, Madhur

    2009-01-01

    Introduction Lichen planus is an immune mediated inflammatory lesion involving skin and mucosal sites including oral mucosa, vulva and rarely vagina. Lichen planus occurring at mucosal sites has been shown to be associated with squamous cell carcinoma in a proportion of cases. To the best of our knowledge, no case of lichen planus of uterine cervix has been reported in the available literature. Case Presentation A 45-year-old female underwent vaginal hysterectomy for uterine prolapse. The res...

  19. Concurrent presentation of erythrodermic lichen planus and squamous cell carcinoma: Coincidence or malignant transformation?

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    Neema M Ali

    2015-01-01

    Full Text Available Lichen planus is a common papulosquamous disorder affecting about 1-2% of the population, neoplastic transformation of cutaneous lichen planus lesions occurs very rarely. A 40 year old female patient presented with a 1 year history of developing multiple, itchy, pigmented lesions over both lower legs which gradually spread to involve the whole body. A few tense bullae were seen on the extremities. An erythematous fleshy lesion was seen on the upper aspect of the left buttock. Skin biopsy from a plaque on the right forearm showed features suggestive of lichen planus. Skin biopsy of a bullae showed a sub epidermal bulla filled with a mixed inflammatory infiltrate. Direct immunofluorescence revealed no immunoreactants along the basement membrane zone. A diagnosis of erythrodermic lichen planus with bullous lichen planus was made. Biopsy of fleshy lesion of left buttock revealed a moderately differentiated squamous cell carcinoma. Erythrodermic lichen planus with bullous lesions and secondary squamous cell carcinoma; these occurences in a single patient is extremely rare and has not been previously reported to the best of our knowledge.

  20. Concurrent Presentation of Erythrodermic Lichen Planus and Squamous Cell Carcinoma: Coincidence or Malignant Transformation?

    Science.gov (United States)

    Ali, Neema M; Bhat, Ramesh; Rao, Shwetha B

    2015-01-01

    Lichen planus is a common papulosquamous disorder affecting about 1-2% of the population, neoplastic transformation of cutaneous lichen planus lesions occurs very rarely. A 40 year old female patient presented with a 1 year history of developing multiple, itchy, pigmented lesions over both lower legs which gradually spread to involve the whole body. A few tense bullae were seen on the extremities. An erythematous fleshy lesion was seen on the upper aspect of the left buttock. Skin biopsy from a plaque on the right forearm showed features suggestive of lichen planus. Skin biopsy of a bullae showed a sub epidermal bulla filled with a mixed inflammatory infiltrate. Direct immunofluorescence revealed no immunoreactants along the basement membrane zone. A diagnosis of erythrodermic lichen planus with bullous lichen planus was made. Biopsy of fleshy lesion of left buttock revealed a moderately differentiated squamous cell carcinoma. Erythrodermic lichen planus with bullous lesions and secondary squamous cell carcinoma; these occurences in a single patient is extremely rare and has not been previously reported to the best of our knowledge.

  1. The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study

    Science.gov (United States)

    Llorente-Pendás, Santiago; González-Garcia, Manuel; García-Martín, José-Manuel

    2016-01-01

    Background Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus. Material and Methods The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years. Results The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56.4 years old. None of the patients smoked during the study. As bilateral reticular was clinically diagnostic criterion, the second most frequent clinical form was the plaque form (n=10; 71.4%), followed by the atrophic (n=6; 42.8%), and erosive forms (n=4; 28.5%). Clinically it spread towards attached gingival mucosa and the hard palate. In the histopathologic study, there were a predominance of hyperkeratosis and verrucous epithelial hyperplasia. Three of the cases progressed to a squamous cell carcinoma, and one patient developed two verrucous carcinoma. Conclusions Further research is needed to demonstrate if proliferative multifocal oral lichen planus and proliferative multifocal oral leukoplakia are the same disorder but have different behaviour of malignancy for reasons of origin. Key words:Oral lichen planus, proliferative verrucous oral leukoplakia, malignant oral lichen planus, multifocal verrucous oral lichen planus, proliferative verrucous oral lichen planus. PMID:27031060

  2. Genital lichen planus: update on diagnosis and treatment.

    Science.gov (United States)

    Zendell, Kathleen

    2015-12-01

    Lichen planus (LP) is an inflammatory autoimmune disease that affects both glabrous and mucosal skin. Although pathophysiology has not yet been fully defined, LP is a T-cell mediated disorder that demonstrates an increased Th1 cytokine expression as well as T-cell reactivity against basement membrane zone components. In males, genital LP often takes its more classic form as pink, shiny, flat-topped papules on the glans and coronal sulcus. In women, erosive disease is most common and often leads to significant scarring and sexual dysfunction. Therapeutic management is challenging, and control rather than cure is the goal. Topical corticosteroids remain first-line therapy, but some women will require systemic immunosuppressants to achieve remission. Surgery is less common for women with significant scarring who wish to resume sexual activity. Further research is needed on pathogenesis, and randomized controlled trials are necessary to better define best treatments for this chronic disease.

  3. Metabolic Derangements in Lichen Planus - A Case Control Study

    Science.gov (United States)

    Kar, Bikash Ranjan; Panda, Maitreyee

    2016-01-01

    Introduction An association between psoriasis and metabolic syndrome has been established in previous studies. Lichen Planus (LP) is also a chronic inflammatory disease morphologically related to psoriasis and few studies have shown association of metabolic derangements in LP. Aim To study the association of metabolic derangements in LP. Materials and Methods A prospective case control study was undertaken for a period of one year. Age and sex matched patients of LP and other non-inflammatory diseases were taken as cases and controls respectively. Data on height, weight, lipid profile and fasting blood glucose levels were collected for all the patients. Body Mass Index (BMI) was calculated. Results A total of 80 patients were recruited, 40 cases and 40 controls. The mean values for all the lipid and glucose parameters were high in cases as compared to controls with significant p-values. Conclusion In the present study metabolic derangements were seen in patients with LP. PMID:28050485

  4. A Rare Colocalization of Lichen Planus and Vitiligo

    Directory of Open Access Journals (Sweden)

    David Veitch

    2015-01-01

    Full Text Available We report an unusual manifestation of vitiligo colocalizing with lichen planus (LP. A 76-year-old Greek male presented with a history of a red, scaly, itchy, asymmetrical patch located at the umbilicus within a well-demarcated depigmented macule of vitiligo. Histology showed features of a lichenoid interface dermatitis, favouring a diagnosis of LP. Colocalization of LP and vitiligo has rarely been reported in the literature. After reviewing the literature, we believe that at present there is insufficient evidence to resolve the uncertainties in the aetiology of this colocalization. It seems to us that the association between LP and vitiligo is more than coincidental, but none of the theories discussed in this paper can sufficiently account for it. Rather, the association is likely to be multifactorial in its pathogenesis.

  5. Oral lichen planus to oral lichenoid lesions: Evolution or revolution

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    Bhavin B Dudhia

    2015-01-01

    Full Text Available The diagnosis between different diseases may be impaired by clinical and histopathologic similarities, as observed in the oral lichen planus (OLP and oral lichenoid lesion (OLL. Inspite of similar clinicopathological features; etiology, diagnosis and prognosis differ which mandates separation of OLL from OLP. Hence, it is essential for the oral physician and oral pathologist to be familiarized with the individual variations among clinicopathological features of OLP and OLL as well as to obtain a thorough history and perform a complete mucocutaneous examination in addition to specific diagnostic testing. The difficulties faced to establish the diagnosis between these two pathologies are widely investigated in the literature with a lack of definite conclusion. This review is an attempt to throw some light on these clinicopathologic entities with the aim to resolve the diagnostic dilemma.

  6. Oral lichen planus to oral lichenoid lesions: Evolution or revolution.

    Science.gov (United States)

    Dudhia, Bhavin B; Dudhia, Sonal B; Patel, Purv S; Jani, Yesha V

    2015-01-01

    The diagnosis between different diseases may be impaired by clinical and histopathologic similarities, as observed in the oral lichen planus (OLP) and oral lichenoid lesion (OLL). Inspite of similar clinicopathological features; etiology, diagnosis and prognosis differ which mandates separation of OLL from OLP. Hence, it is essential for the oral physician and oral pathologist to be familiarized with the individual variations among clinicopathological features of OLP and OLL as well as to obtain a thorough history and perform a complete mucocutaneous examination in addition to specific diagnostic testing. The difficulties faced to establish the diagnosis between these two pathologies are widely investigated in the literature with a lack of definite conclusion. This review is an attempt to throw some light on these clinicopathologic entities with the aim to resolve the diagnostic dilemma.

  7. Molecular markers in oral lichen planus: A systematic review

    Directory of Open Access Journals (Sweden)

    Shitalkumar Sagari

    2016-01-01

    Full Text Available Oral lichen planus (OLP is a chronic inflammatory mucosal disease that is usually detected in 0.5-2.2% of the human population. Among these, only 0.5-2.9% of the lesions progress to carcinoma. However, there are no prognostic markers available presently to recognize the increased risk in malignant transformation of the lesions. Selected markers for cell proliferation, adhesion, apoptosis and lymphocytic infiltration were analyzed by immunohistochemistry in addition to static cytometry for DNA content. The concept linking OLP and oral squamous cell carcinoma states that chronic inflammation results in crucial DNA damage, which further progresses to development of carcinoma. Even though in the past decade, enormous information has been accumulated on malignant potential of OLP, its transformation still remains unclear. Hence, the purpose of this article was to review cellular and molecular markers to understand the pathogenesis of OLP and its progression toward malignancy.

  8. Oral Lichen Planus as a Preneoplastic Inflammatory Model

    Directory of Open Access Journals (Sweden)

    Eleni A. Georgakopoulou

    2012-01-01

    Full Text Available Oral lichen planus (OLP is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC in the long run. While World Health Organization (WHO classifies OLP as “a potentially malignant disorder,” it is still a matter of debate which mechanisms drive OLP to such a condition. The current hypothesis connecting OLP and OSCC is that chronic inflammation results in crucial DNA damage which over time results in cancer development. Initial studies investigating the OLP and OSCC link were mainly retrospective clinical studies. Over the past years, several amount of information has accumulated, mainly from molecular studies on the OLP malignant potential. This article is a critical review of whether OLP has a malignant potential and, therefore, represents a model of preneoplastic inflammation.

  9. Lichenoid esophagitis: clinicopathologic overlap with established esophageal lichen planus.

    Science.gov (United States)

    Salaria, Safia N; Abu Alfa, Amer K; Cruise, Michael W; Wood, Laura D; Montgomery, Elizabeth A

    2013-12-01

    Lichen planus (LP) affects mucocutaneous surfaces and is characterized by intraepithelial and lamina propria lymphocytosis and squamous cell apoptosis (Civatte bodies). Lichen planus esophagitis (LPE) is underrecognized; concurrent cutaneous disease is present in some patients, but LPE alone is more common. We diagnose patients with characteristic pathologic findings of LPE and known correlation with skin disease or immunofluorescence (IF) results as LPE but use descriptive terminology ("lichenoid esophagitis pattern" [LEP]) when confirmation is unavailable. We reviewed clinicopathologic features of patients diagnosed at our institution with LPE or LEP. There were 88 specimens with LPE or LEP from 65 patients. Most patients were female. Seventeen patients had LPE confirmed by IF. Five patients had both esophageal (1 with IF) and skin LP. Strictures were a prominent presenting feature in LPE patients, with disease distribution more frequent in the upper and lower esophagus. Dysphagia was a common reason for endoscopy in LEP patients. Rheumatologic diseases are more common in patients with LPE compared with LEP. Viral hepatitides and human immunodeficiency virus (HIV) infections are associated with LEP. We defined polypharmacy as patients taking >3 medications; this finding was present in both LPE and LEP cohorts; however, this is a prominent feature in those with established LPE. Progression to dysplasia was noted in both cohorts. About 5% of LPE patients have tandem skin manifestations. LPE is more likely than LEP to arise in women, result in stricture formation, and be associated with rheumatologic disorders and polypharmacy, whereas LEP is associated with viral hepatitis and HIV. Both can progress to neoplasia. As the risk of stricture formation is high in patients with LPE, it is worth performing pertinent IF studies to confirm LPE, although knowledge of the clinical association of LEP with viral hepatitis, HIV, and use of multiple medications is of value in

  10. Lichen planus pemphigoides: four new cases and a review of the literature.

    Science.gov (United States)

    Zaraa, Ines; Mahfoudh, Anis; Sellami, Myriam Kallel; Chelly, Ines; El Euch, Dalenda; Zitouna, Mohamed; Mokni, Mourad; Makni, Sondes; Ben Osman, Amel

    2013-04-01

    Lichen planus pemphigoides (LPP) is a rare autoimmune blistering disease. It appears to be combination of lichen planus and bullous pemphigoid. We describe four new cases of LPP and discuss the epidemiological, clinical, pathological, and therapeutic features of this singular association through a review of the 74 published cases within the English literature. We report four cases of LPP (three women aged respectively 47, 51, and 53 years old, and a 53-year-old man). All patients presented with bullae on lichenoid and normal skin, predominately on the extremities. The diagnosis was confirmed by immunohistological findings. Our patients were treated with oral corticosteroids with a good response. Our review of the literature of 78 cases of LPP (65 adults and 13 children) showed that it involved adults (mean age: 54 years), with a slight female preponderance. A mean lag time between LP and the development of LPP was 8.3 months. LPP is characterized by developing blisters on lichenoid lesions and on uninvolved skin with more acral distribution of bullous lesions. Involvement of palms and soles was more frequent in children. The diagnosis is based on pathological and immunological confrontation. LPP is usually idiopathic, but some cases were reported in association with various drugs. There have also been reports of association with internal malignancy. Most cases of LPP are successfully treated with systemic corticosteroids. In most cases, the prognosis was good.

  11. Increased P-wave dispersion in patients with newly diagnosed lichen planus

    Science.gov (United States)

    Sahin, Musa; Bilgili, Serap Gunes; Simsek, Hakki; Akdag, Serkan; Akyol, Aytac; Gumrukcuoglu, Hasan Ali; Yaman, Mehmet; Bayram, Yasemin; Karadag, Ayse Serap

    2013-01-01

    OBJECTIVE: Lichen planus is a chronic inflammatory autoimmune mucocutaneous disease. Recent research has emphasized the strong association between inflammation and both P-wave dispersion and dyslipidemia. The difference between the maximum and minimum P-wave durations on an electrocardiogram is defined as P-wave dispersion. The prolongation of P-wave dispersion has been demonstrated to be an independent risk factor for developing atrial fibrillation. The aim of this study was to investigate P-wave dispersion in patients with lichen planus. METHODS: Fifty-eight patients with lichen planus and 37 age- and gender-matched healthy controls were included in this study. We obtained electrocardiographic recordings from all participants and used them to calculate the P-wave variables. We also assessed the levels of highly sensitive C-reactive protein, which is an inflammatory marker, and the lipid levels for each group. The results were reported as the means ± standard deviations and percentages. RESULTS: The P-wave dispersion was significantly higher in lichen planus patients than in the control group. Additionally, highly sensitive C-reactive protein, LDL cholesterol, and triglyceride levels were significantly higher in lichen planus patients compared to the controls. There was a significant positive correlation between highly sensitive C-reactive protein and P-wave dispersion (r = 0.549, p<0.001) in lichen planus patients. CONCLUSIONS: P-wave dispersion increased on the surface electrocardiographic measurements of lichen planus patients. This result may be important in the early detection of subclinical cardiac involvement. Increased P-wave dispersion, in terms of the tendency for atrial fibrillation, should be considered in these patients. PMID:23778479

  12. Increased P-wave dispersion in patients with newly diagnosed lichen planus

    Directory of Open Access Journals (Sweden)

    Musa Sahin

    2013-06-01

    Full Text Available OBJECTIVE: Lichen planus is a chronic inflammatory autoimmune mucocutaneous disease. Recent research has emphasized the strong association between inflammation and both P-wave dispersion and dyslipidemia. The difference between the maximum and minimum P-wave durations on an electrocardiogram is defined as P-wave dispersion. The prolongation of P-wave dispersion has been demonstrated to be an independent risk factor for developing atrial fibrillation. The aim of this study was to investigate P-wave dispersion in patients with lichen planus. METHODS: Fifty-eight patients with lichen planus and 37 age- and gender-matched healthy controls were included in this study. We obtained electrocardiographic recordings from all participants and used them to calculate the P-wave variables. We also assessed the levels of highly sensitive C-reactive protein, which is an inflammatory marker, and the lipid levels for each group. The results were reported as the means ± standard deviations and percentages. RESULTS: The P-wave dispersion was significantly higher in lichen planus patients than in the control group. Additionally, highly sensitive C-reactive protein, LDL cholesterol, and triglyceride levels were significantly higher in lichen planus patients compared to the controls. There was a significant positive correlation between highly sensitive C-reactive protein and P-wave dispersion (r = 0.549, p<0.001 in lichen planus patients. CONCLUSIONS: P-wave dispersion increased on the surface electrocardiographic measurements of lichen planus patients. This result may be important in the early detection of subclinical cardiac involvement. Increased P-wave dispersion, in terms of the tendency for atrial fibrillation, should be considered in these patients.

  13. Extra genital lichen sclerosus et atrophicus with cutaneous distribution and morphology simulating lichen planus

    Directory of Open Access Journals (Sweden)

    Bhumi Patel

    2015-01-01

    Full Text Available Lichen sclerosus et atrophicus (LSA also known as Csillag′s disease, characterized by small, porcelain white, sclerotic areas occur at any site on the skin including mucosa. There is strong association of autoimmune disorders with LSA. Lichen planus (LP is an inflammatory, papulosquamous disorder characterized by erythematous to violaceous, flat topped, polygonal, pruritic papules distributed mainly on flexural aspects like wrist, around ankles, lumbar region, trunk and neck and also involves mucous membranes, hair, and nail. LP and LSA share similar clinical and pathological features. There have been a few reported cases in the literature of the coexistence of LP and LSA. We reported a case of 39-years-old female having LSA with cutaneous distribution and morphologically simulating LP.

  14. A prodigious lichen planus pigmentosus: The Wolf’s isotopic response

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    Yugandar I, Shiva Kumar, Sai Prasad, Srilakshmi P, Akshaya N, Abhiram R, Sujalalitha K, Meghana GB

    2014-07-01

    Full Text Available Lichen planus is a pruritic, benign, papulosquamous, inflammatory dermatosis of unknown etiology that affects either or all of the skin, mucous membrane, hair and nail. In its classic form, it presents with violaceous, scaly, flat-topped, polygonal papules. A female patient aged 43 years with a history of pruritic eruptions for a period of one month over the right armpit and back of the right chest (C8, T1, T2, T3 Dermatomes. She had a history of herpes zoster in the same localization, which had been treated with topical and oral acyclovir two months prior to this visit. This variant may represent as an example of the Wolf’s isotopic response. We presented our case because of its rarity as a Dermatomal distribution of lichen planus pigmentosus (LPP and its appearance in the area of healed herpes zoster as an isotopic response. The case well highlights this unusual condition and represents the first case reported in Indian dermatology literature to our best of knowledge. The clinical and histological features of this case are described here.

  15. Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls

    DEFF Research Database (Denmark)

    Larsen, K R; Johansen, J D; Reibel, J;

    2016-01-01

    BACKGROUND: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology affecting the skin and oral mucosa. Oral lichenoid lesions (OLL), like oral contact reactions, may resemble oral lichen planus (OLP) both clinically and histopathologically. As OLP and OLL are hyperkeratotic...

  16. A comparative study of oral lichen planus and leukoplakia in two Argentine populations.

    Science.gov (United States)

    Femopase, F L; Binagui, M V; López de Blanc, S; Gandolfo, M; Lanfranchi, H E

    1997-01-01

    Oral Lichen Planus and Leukoplakia are two precancerous lesions of great relevance in oral pathology. A total of 4183 patients from the National University of Córdoba (UNC) and 4838 patients from the University of Buenos Aires (UBA) who had been admitted to the corresponding Oral Pathology Departments were analyzed. Of the total number of patients, 476 corresponded to Lichen Planus cases and 418 to Leukoplakia cases. Of the 476 Lichen Planus cases, 330 came from UBA and 146 from UNC, whereas of the 418 cases of Leukoplakia, 284 came from UNC and 134 from UBA. These differences were statistically significant (p Oral Pathology Departments. The association between diabetes and Lichen Planus was similar for both centers, 11.5% for UNC and 14% for UBA. Similarly, no differences were found in terms of the association with tobacco consumption and dental microtrauma. Twenty-two percent of UNC patients were smokers whereas only 11% of UBA patients were smokers. This finding could explain the larger amount of Leukoplakia in UNC. The differences in the incidence of Lichen Planus could be attributed to the fact that the Buenos Aires population is under greater stress and the higher incidence of Leukoplakia in UNC could be related to the smoking habits of this population.

  17. A clitoral verrucous carcinoma in an area of lichen planus has aggressive features.

    Science.gov (United States)

    Tjalma, Wiebren A A; Siozopoulou, Vasiliki; Huizing, Manon T

    2017-01-06

    Verrucous carcinoma of the vulva is extremely rare. It is a slow growing, low malignant variant of a squamous cell carcinoma with a cauliflower appearance. Women with lichen planus have an increased risk of developing vulval cancer. A 79-year-old woman consulted for vulval itching. On clinical examination, a 3-cm large verrucous clitoral cancer in an area of lichen planus was seen. Based on her last clinical examination, the growth was estimated to be 1 cm(2) per month with an invasion depth after 6 months of 5 mm. A tumor developing in an area of lichen planus appears to have more aggressive features. This is the first time that the growth of a verrucous carcinoma has been documented in an area of lichen planus. Clinicians and patients should be aware of the aggressive behavior of cancers developing in areas of lichen planus and adjust their surgical management together with the follow-up strategy.

  18. The Expression of TNF-α and ICAM-1 in Lesions of Lichen Planus and Its Implication

    Institute of Scientific and Technical Information of China (English)

    CHEN Xue; LIU Zhixiang; YUE Qing; LIU Houjun; WU Yan; LI Jiawen

    2007-01-01

    In order to investigate the role of TNF-α and ICAM-1 in the pathogenesis of lichen planus, immunohistechemistty was used to detect the expression of TNF-α and ICAM-1 in skin le- sions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-α and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the in- crease of TNF-α and that of ICAM-1 in lichen planus. The expression of TNF-α and ICAM-1 might play an important role in the development of lichen planus.

  19. Evaluation on Malignant Transformation of Oral Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    目的:口腔扁平苔藓(oral lichen planus,OLP)是否属于癌前病变,至今仍存在较大的争论.本文的目的在于评估OLP的癌变性质.方法:报告1995~2002年之间9例OLP的癌变病例.结果:5例OLP患者同时或继发为口腔鳞状细胞癌,1例为疣状癌,3例为上皮异常增生.其中7例发生在原OLP存在的部位,1例发生在其它部位,1例在同一部位同时存在OLP和鳞状细胞癌.OLP的癌变常发生在糜烂型和萎缩型,发生于颊粘膜、舌或牙龈.根据所制定的OLP的诊断及癌变标准,4例OLP患者发生了癌变.结论:OLP具有一定的癌变潜力,对OLP患者应每年随访2~4次,尤其是对发生在颊粘膜、舌或牙龈的糜烂型和萎缩型的患者.%Objective:To evaluate the malignant transformation of oral lichen planus(OLP).Methods:The malignant transformation of oral lichen planus was investigated between 1995 and 2002.The symptoms,the location of lesions,clinical history and histopathological feathers were carefully recorded.Results:5 cases had concurrent or subsequent oral squamous cell carcinoma (SCC),1 case developed verrucous carcinoma in the lower lip,3 patients were epithelial dysplasia histopathologically. In addition,7 patients were in an area of pre-existing OLP,1 in other site, in 1 case the diagnosis of OLP and SCC was synchronous.The malignant transformation occurred most frequently in the erosive and atrophic forms of OLP,and in the buccal mucosa, tongue or gingiva.According to the criteria of diagnosis and malignant transformation of OLP we established, 4 of the 9 patients were considered to develop malignant transformation.Conclusions:These data suggest the probability of some cases of at least OLP having an intrinsic property predisposing to malignant transformation.It is necessary to follow-up the patients regularly two to four times annually and to find early signs of malignant transformation.Follow-up are particularly important in patients with erosive and

  20. Lupus erythematosus/lichen planus overlap syndrome: successful treatment with acitretin.

    Science.gov (United States)

    Lospinoso, D J; Fernelius, C; Edhegard, K D; Finger, D R; Arora, N S

    2013-07-01

    Lupus erythematosus/lichen planus overlap syndrome is a rare disorder combining the clinical, histological and immunopathological features of both lupus erythematosus (LE) and lichen planus (LP). Cutaneous lesions mostly affect the distal arms, legs, face and trunk. Palmoplantar involvement is felt to be characteristic of this condition. Plaques are often painful, centrally atrophic, bluish-red to hypopigmented in color, large, and scaly. On biopsy of clinically ambiguous lesions, histopathological features of one or both processes can be found, obscuring the diagnosis and complicating prognosis and treatment. Thus, direct immunofluorescence has become an essential tool in helping to diagnose this condition. In this report we describe the unique clinical and immunohistopathological manifestations of lupus erythematosus/lichen planus overlap syndrome along with a successful response to treatment with acitretin.

  1. Clinical, Histological and Immunofluorescence Features of Lichen Planus Pemphigoides: A Report of Two Cases

    Directory of Open Access Journals (Sweden)

    Suhan Günaştı

    2010-03-01

    Full Text Available Lichen planus pemphigoides (LPP is a rare, acquired and autoimmune disorder. LPP clinically, histologically and immunologically appears to be a combination of lichen planus and bullous pemphigoides. LPP is usually idiopathic but some cases have been associated with drugs, phototherapy, infections and malignancy. It has different clinical variants such as presenting with only oral lesions; with oral and cutaneous lesions and with only cutaneous lesions, respectively. We present two cases with typical histologic and immunofluorescence features of LPP. Our 55 years old male case had typical lichen planus lesions with widespread bulla and erosions; he responded systemic steroid treatment in a short time. Bulla and erosions were not prominent in our 16 years old female case and with topical treatments to her lesions improved in a short time. LPP should be considered in the clinical differential diagnosis of vesiculoerosive oral mucosal and cutaneous diseases.

  2. The coexistence of oral lichen planus and psoriasis vulgaris – a case report

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    Paulina Kiluk

    2016-05-01

    Full Text Available Introduction . Psoriasis and lichen planus are common dermatological conditions, whose coexistence is rarely described. Although the exact etiopathogenesis of both diseases is still unknown, autoimmune factors play an important role in their development. A common feature is also the occurrence of the Köbner phenomenon. The principal differences concern the clinical, histological and immunological events. Objective. To present a patient with oral lichen planus, in whom psoriasis developed. Case report. A 75-year-old patient, with a 3-year history of oral lichen planus, presented itchy erythematous skin lesions initially located in the intertriginous area. Outpatient treatment consisting of topical and oral antifungal medications did not bring significant improvement. Skin biopsy confirmed the diagnosis of psoriasis. Treatment with tar ointment and topical tacrolimus was carried out, resulting in gradual improvement. Conclusions . A review of the literature indicates the existence of possible, but still unexplained, linkages between these two diseases.

  3. Comparative analysis of cell proliferation ratio in plaque and erosive oral lichen planus: An immunohistochemical study

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    C Pramod Redder

    2014-01-01

    Full Text Available Background: Proliferating cell nuclear antigen (PCNA is a nuclear protein synthesized in the late G1 and S-phase of the cell cycle. Detection of this protein represents a useful marker of the proliferation status of lesions. This study has been carried out to evaluate the cell proliferation rate in oral lichen planus (OLP and comparison between plaque and erosive lichen planus, which indicates the potential for malignant transformation. Materials and Methods: This study was comprised of 64 cases of histologically proven lichen planus, out of which 32 cases of plaque and erosive each was taken. Two sections were taken from each, one for H and E staining to verify histological diagnosis according to Eisenberg criteria, other sections were stained according to super sensitive polymer horse radish peroxidise method for identifying immunohistochemical expression of PCNA. Data were statistically analyzed by Tukey high-range statistical domain test. Statistically significant P value was considered <0.05. Results: In two types of lichen planus, erosive type (66.86% showed higher expression of PCNA followed by plaque (17.07%. Overall, P value was <0.001, which was statistically significant. It indicates that proliferation activity is more in erosive lichen planus followed by plaque type, which ultimately results in increased rate of malignant transformation. Conclusion: PCNA is a good nuclear protein marker to evaluate the proliferation status of OLP. Out of the two types of lichen planus, erosive type possesses more proliferative ratio and chances of malignant change is more in this type. It emphasizes the importance of long-term follow-up with erosive type when compared with plaque type.

  4. The Relationship between Lichen Planus and Carotid Intima Media Thickness

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    C, Koseoglu; M, Erdogan; G, Koseoglu; O, Kurmus; AG, Ertem; TH, Efe; GI, Kurmus; T, Durmaz; T, Keles; E, Bozkurt

    2016-01-01

    Background Lichen planus (LP) is a chronic inflammatory disease. Although the association between chronic inflammation and subclinical atherosclerosis has been reported in the literature, the relationship between LP and carotid intima media thickness (CIMT) has not been previously investigated. The aim of this study was to investigate the relationship between LP and CIMT. Methods One hundred eleven LP patients and 105 controls were enrolled in the study. Then, CIMT examination was performed with an ultrasonography device. Cross-sectional associations of LP with CIMT were analyzed using linear regression models adjusted for related confounders. Results No statistical difference was found between LP and the controls except for the female gender, white blood cell, LDL cholesterol and triglycerides (p = 0.046, p = 0.019, p = 0.011 and p = 0.013, respectively). Significant difference was found between the groups in terms of CIMT (0.90 ± 0.2 mm vs. 0.61 ± 0.3 mm, p = 0.001). CIMT was correlated with longevity of the LP, but we did not find LP to be an independent predictor of increased CIMT in logistic regression analysis (r = 0.449, p < 0.001, β = -0.117, p = 0.092; respectively). Conclusions The results of our study suggested that LP was associated with increased mean CIMT, and furthermore that CIMT was correlated with longevity of LP. However, LP was not an independent predictor of increased CIMT. PMID:27899862

  5. A CLINICAL & EPEDEMIOLOGICAL PROFILE OF LICHEN PLANUS AMONG CHILDREN

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    Mohan Rao

    2015-10-01

    Full Text Available Lichen planus (LP is a common papulosquamous disorder of auto-immune Etiology characterised by pruritic, polygonal, purple, papules which was first described by Erasmus Wilson in 1869. LP affects all age groups and both sexes equally. Most cases have been reported in adult population but a few case series were present among children. This prompted us to carry-out the present study. MATERIALS & METHODS: The present study was carried out for a period of 1year from April 2014 to April 2015 which includes a sample size of 20 patients (n=20, attended to the dermatology OPD, Andhra Medical College, Visakhapatnam. Present study was done in children of less than 12 years of age including both sexes. Routine investigations such as hemogram, liver function test, and renal function test & serological test have been done, detailed immunisation history has been recorded, detailed medical & family history as well as drug history has been recorded. RESULTS: in our study the most common age group was in between 5 and 10 years. Among sex distribution male children were predominantly affected. Regarding the distribution of lesions lower limbs followed by trunk were the common sites to be effected, the most common morphological variants observed in our study were classical type followed by hypertrophic variant. CONCLUSION: our study concluded that the common age group was between 5 and 10 years and the most common presentation was classical type effecting the male children predominantly.

  6. Clinical and demographic characteristics of 165 patients with lichen planus

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    Bilge Bülbül Şen

    2014-03-01

    Full Text Available Objective: Lichen planus (LP, is a papulosquamous inflammatory disease, which involves the skin, mucous membranes, nails and scalp. The incidence varies according to geographical regions. In this study, it was aimed to detect the clinical and demographic characteristics of the patients with LP who have been under follow-up at our clinic. Methods: One hundred sixty five patients, who were diagnosed as LP in our clinic between 2010 and 2013, were enrolled to the study. The age, gender, disease duration, time of onset of disease, characteristics of involvement, associated systemic diseases, laboratory findings and treatment were recorded retrospectively. Results: In our study, 0.6% of all patients admitted to our clinic were diagnosed as LP. A total of 165 patients included in the study, 92 women (56% and 73 men (44%, respectively. Patients’ ages ranged 8-78 (mean 44.7±16.7. Disease duration ranged from 1 month to 20 years (mean 15.6±29.7. One hundred thirty four patients (81.2% had skin involvement, 51 (31% had oral mucosal involvement, and 15 (9% had genital involvement. Five (4.5% of 111 patients with viral hepatitis tests were positive for hepatitis C virus. Hepatitis B virus positivity was seen in 4 (4% patients. Conclusion: There is a need for further studies with more patients to better understand the epidemiological, clinical and pathological characteristics of LP. We believe that our study will contribute to the determination of our country’s data.

  7. Lichen planus and lichenoid reactions as a systemic disease.

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    Lukács, Judit; Schliemann, Sibylle; Elsner, Peter

    2015-01-01

    Lichen planus (LP) is a chronic disease that involves the skin, scalp, mucous membranes, and nails. The etiology of LP is still unknown; however, some external and internal factors (eg. drugs, stress, hepatitis C virus) have been suggested to trigger the disease. Many studies have investigated an immunologic pathogenesis that is probably related to T-cell autoimmunity with the keratinocyte as the target cell. Altered self-antigens on the surface of basal keratinocytes modified by viruses or by drugs are believed to be the targets of the T-cell response. Various drugs and contact allergens like amalgam may cause lichenoid reactions, which are the main differential diagnoses of LP. Clinically and histologically, LP and lichenoid reactions cannot be distinguished with certainty in many cases. Treatment is mainly symptomatic and can be difficult. The first-line therapies for LP are topical or systemic corticosteroids; however, some studies have mentioned acitretin leading to similar improvement. Medical treatment, together with patient education and psychosocial support, can significantly benefit patients' quality of life.

  8. Efficaly of the combination of compound glycyrrhizin and becotide to treat oral lichen planus%复方甘草酸苷与丙酸倍氯米松气雾剂合用治疗口腔扁平苔藓

    Institute of Scientific and Technical Information of China (English)

    吴晓金; 于小兵

    2009-01-01

    OBJECTIVE To survey the clinical curative effect of the combination of compound glycyrrhizin and becotide to treat oral lichen planus. METHODS 61 oral lichen planus patients were randomly distributed as treatment group(31) and con-trol group, compound glycyrrhizin tablet and becotide spray were used in the treatment group, and local triamcinolone aectonide injection were applied to the control group, the therapeutic effect were evaluated by Response Evaluation Criteria. RESULTS The total effective rate in the treatment group was 90.3%, which is significantly better than that of the control group(P<0.01). CONCLUSION The combination of compound Glycyrrhizin and becotide have good effect to oral lichen planus.%目的:观察复方甘草酸苷与丙酸倍氯米松气雾剂合用治疗口腔扁平苔藓的临床疗效.方法:61例口腔扁平苔藓患者随机分为治疗组31例和对照组30例,治疗组口服复方甘草酸苷片并外喷丙酸倍氯米松气雾刺,对照组局部注射曲安奈德,通过疗效评价标准进行评定.结果:治疗组总有效率为90.3%,明显优于对照组,差异具极显著性(P<0.01).结论:复方甘草酸苷与丙酸倍氯米松气雾剂合用对口腔扁平苔藓有较好疗效,值得在临床推广应用.

  9. Cytomorphometric analysis of exfoliated cells in oral lichen planus

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    Chitturi Suryaprakash Ravi Teja

    2014-01-01

    Full Text Available Background: Tumors are distinguished from normal tissues partly by their pronounced variability of cellular and nuclear dimensions. Therefore, such factors may be an indicator to assess whether the cells are malignant or not. Exfoliative cytology is a reliable tool in assessing such changes in the uterine cervix and has been used in the oral cavity also with success. The aims and objectives of the following study were to evaluate the malignant changes by assessing the quantitative parameters such as cytoplasmic diameter, cytoplasmic perimeter and cytoplasmic area (CD, CP, CA and nuclear diameter, nuclear perimeter and nuclear area (ND, NP, NA and cytoplasmic to nuclear ratio in the exfoliated cells of various subtypes of oral lichen planus (OLP using cytomorphometry. Materials and Methods: Oral exfoliated cells from nineteen cases of histologically proven OLP (1 atrophic, 13 reticular, 4 erosive and 1 plaque and ten controls with healthy mucosa were taken and stained by Feulgen-Rossenback reaction and cytomorphometric analysis was performed using an image analysis software. The parameters taken into account were CD, CP, CA and ND, NP, NA. Furthermore CA/NA was calculated. The parameters were statistically analyzed using the t-test. Results: Cytomorphometric analysis of all the parameters showed no significant difference between the control group and the reticular/plaque subtypes, whereas statistically significant (P < 0.05 differences was obtained between the control group and the atrophic/erosive subtypes group when compared using t-test. Conclusions: The cytomorphometric analysis of OLP shows that erosive/atrophic subtypes of OLP are at more risk and exfoliative cytology and cytomorphometry can be used as a tool to assess the malignant changes.

  10. Alterations in lipid metabolism and antioxidant status in lichen planus

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    Falguni H Panchal

    2015-01-01

    Full Text Available Background: Lichen planus (LP, a T-cell-mediated inflammatory disorder, wherein inflammation produces lipid metabolism disturbances, is linked to increase in cardiovascular (CV risk with dyslipidemia. Increased reactive oxygen species and lipid peroxides have also been implicated in its pathogenesis. Aim and Objective: The aim of the study was to evaluate the status on lipid disturbances, oxidative stress, and inflammation in LP patients. Materials and Methods: The study was initiated after obtaining Institutional Ethics Committee permission and written informed consent from participants. The study included 125 patients (74 LP patients and 51 age and sex-matched controls visiting the outpatient clinic in the dermatology department of our hospital. Variables analyzed included lipid profile, C-reactive protein (CRP, malondialdehyde (MDA, and catalase (CAT activity. Results: Analysis of lipid parameters revealed significantly higher levels of total cholesterol (TC, triglycerides, and low-density lipoprotein cholesterol (LDL-C along with decreased levels of high-density lipoprotein cholesterol (HDL-C in LP patients as compared to their respective controls. LP patients also presented with a significantly higher atherogenic index that is, (TC/HDL-C and LDL-C/HDL-C ratios than the controls. A significant increase in CRP levels was observed among the LP patients. There was a statistically significant increase in the serum levels of the lipid peroxidation product, MDA and a statistically significant decrease in CAT activity in LP patients as compared to their respective controls. A statistically significant positive correlation (r = 0.96 was observed between serum MDA levels and duration of LP whereas a significantly negative correlation (r = −0.76 was seen between CAT activity and LP duration. Conclusion: Chronic inflammation in patients with LP may explain the association with dyslipidemia and CV risk. Our findings also suggest that an increase in

  11. Actinic lichen planus in a Japanese man: first case in the East Asian population.

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    Dekio, Itaru; Matsuki, Shingo; Furumura, Minao; Morita, Eishin; Morita, Akimichi

    2010-12-01

    Actinic lichen planus (ALP) is a rare variant of lichen planus in which lichen planus develops on the light-exposed areas of the skin. ALP is reported to occur in the African, Middle Eastern,and Indian populations, with very few cases reported in Caucasians. Here, we report a case of ALP in a Japanese man; to the best of our knowledge, this is the first reported occurrence of ALP in the East Asian population. A 52-year-old Japanese man developed recurrent painful annular erythema on the face and hands. Histopathological examination of his skin biopsy revealed lichenoid-type infiltrates of lymphocytes and histiocytes. We established a diagnosis of ALP on the basis of the distribution of eruptions only on the sunlight-exposed areas and histological findings. Oral administration of systemic steroids proved effective in improving his condition. Lichen planus is known to be induced by an irritant (Koebner phenomenon);we believe that our patient is genetically susceptible to sunlight exposure and that sunlight acted as an irritant stimulating the development of ALP.

  12. A study of depression and quality of life in patients of lichen planus.

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    Sawant, Neena S; Vanjari, Nakul A; Khopkar, Uday; Adulkar, Satish

    2015-01-01

    The precise cause of lichen planus is unknown, but the disease seems to be immunologically mediated. It is a psychocutaneous disorder. Due to scarcity of Indian studies in this field, we decided to study in patients of lichen planus the prevalence of depression and quality of life with comparison of the same in both the genders. Patients diagnosed as having lichen planus by consultant dermatologist were enrolled after informed consent and ethics approval. 45 patients were screened, of which 35 who satisfied the criteria were taken up for the study. A semistructured proforma was designed to collect the necessary information with administration of dermatology life quality index and Beck's depression inventory. While 25% were depressed with females being more affected than males, quality of life was impaired in more than 90% patients. Impairment was maximum due to symptoms and illness feelings, disturbed daily activities, or work and time consumption in treatment. There was a strong association between depression and impairment in quality of life in both the genders. This study helps in early identification of psychological problems in lichen planus patients and in planning their future course of management, hence reducing the lack of productivity and improving the prognosis and quality of life.

  13. A Study of Depression and Quality of Life in Patients of Lichen Planus

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    Sawant, Neena S.; Vanjari, Nakul A.; Khopkar, Uday; Adulkar, Satish

    2015-01-01

    The precise cause of lichen planus is unknown, but the disease seems to be immunologically mediated. It is a psychocutaneous disorder. Due to scarcity of Indian studies in this field, we decided to study in patients of lichen planus the prevalence of depression and quality of life with comparison of the same in both the genders. Patients diagnosed as having lichen planus by consultant dermatologist were enrolled after informed consent and ethics approval. 45 patients were screened, of which 35 who satisfied the criteria were taken up for the study. A semistructured proforma was designed to collect the necessary information with administration of dermatology life quality index and Beck's depression inventory. While 25% were depressed with females being more affected than males, quality of life was impaired in more than 90% patients. Impairment was maximum due to symptoms and illness feelings, disturbed daily activities, or work and time consumption in treatment. There was a strong association between depression and impairment in quality of life in both the genders. This study helps in early identification of psychological problems in lichen planus patients and in planning their future course of management, hence reducing the lack of productivity and improving the prognosis and quality of life. PMID:25802892

  14. Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype

    DEFF Research Database (Denmark)

    Kragelund, Camilla; Jensen, Siri Beier; Hansen, Claus

    2014-01-01

    Objective. This study aimed to determine if the activity of the environmentally influenced cytochrome P450 enzyme CYP1A2, alone or in combination with CYP2D6*4 genotype, discriminates subgroups of oral lichen planus (OLP) according to lifestyle factors and clinical manifestations. Study Design. A...

  15. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective study.

    NARCIS (Netherlands)

    Meij, van der E.H.; Schepman, K.P.; Waal, van der I.

    2003-01-01

    OBJECTIVES: The possible malignant transformation of oral lichen planus (OLP) is the subject of an ongoing and controversial discussion in the literature. The main criticism of studies on this subject relates to the lack of sufficient data to support the initial diagnosis of OLP in cases that finall

  16. Oral lichen planus and the p53 family: what do we know?

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    Ebrahimi, M.; Nylander, K.; van der Waal, I.

    2011-01-01

    Oral lichen planus (OLP) is a relatively common chronic disease of the oral mucosa for which the aetiopathogenesis is not fully understood. It mainly affects middle aged and elderly. The finding of autoantibodies against p63, a member of the p53 family, is a strong indication of autoimmunity as a ca

  17. Comparison of Glycyrrhiza glabra Inorabase With Triamcinolone Acetonide Orabase in the Treatment of Oral Lichen Planus

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    Najafi

    2016-07-01

    Full Text Available Background Lichen planus is a chronic inflammatory mucocutaneous disease that is most commonly found in middle-aged women. A wide spectrum of topical and systemic therapies have been applied for treatment of this condition. Objectives The aim of this study was to compare the efficacy and safety of 1% Glycyrrhiza glabra in orabase with 0.1% Triamcinolone Acetonide paste in treating oral lichen planus (OLP. Patients and Methods In this study, 22 patients were randomly assigned to one of two equal groups. They received either Glycyrrhiza glabra or Triamcinolone Acetonide four times daily for a total of one month and were followed-up for three months. The patients were assessed for painful symptoms, measured by the visual analogue scale (VAS, and lesion size via Thongaprassom. The analysis and comparison of pain scores and the size of the lesions' clinical and symptomatic response rates between the two groups were performed using the Mann-Whitney U-test and SPSS 13.0 computer software. Results Ten patients in the Glycyrrhiza glabra group and 12 patients in the triamcinolone acetonid group completed the four-month trial course. Both Glycyrrhiza glabra and Triamcinolone Acetonid reduced burning symptoms. Clinical scores in both groups also significantly improved over the one-month treatment period. The difference between the two groups was not statistically significant (P = 0.442. Conclusions This study showed that topical Glycyrrhiza glabra appeared to be a promising alternative in the treatment of OLP. Further studies should be conducted to assess the long-term effects of Glycyrrhiza glabra.

  18. Evaluation of the Serum Zinc Level in Erosive and Non-Erosive Oral Lichen Planus

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    Gholizadeh N.

    2013-10-01

    Full Text Available Statement of Problem: Lichen planus is a chronic inflammatory immunologic-based disease involving skin and mucosa. This disease is generally divided into two categories: erosive and non-erosive. Many etiologic factors are deliberated regarding the disease; however, the disorders of immune system and the role of cytotoxic T-lymphocytes and monocytes are more highlighted. Zinc is an imperative element for the growth of epithelium and its deficiency induces the cytotoxic activity of T-helper2 cells which seems to be associated with lichen planus. Purpose: This study aimed to evaluate the levels of serum zinc in erosive and non-erosive oral lichen planus (OLP and compares it with the healthy control group to find out any feasible inference. Materials and Method: A total of 22 patients with erosive oral lichen planus, 22 pa-tients with non erosive OLP and 44 healthy individuals as the control group were recruited in this descriptive-comparative study. All the participants were selected from the referees to the department of oral medicine, school of dentistry, Tabriz University of medical sciences. Serum zinc level was examined for all the individuals with liquid-stat kit (Beckman Instruments Inc., Carlsbad, CA. Data were analyzed by adopting the ANOVA and Tukey tests through SPSS 16 statistical software. Results: The mean age of patients with erosive and non-erosive LP was 41.7 and 41.3 years, respectively. The mean age of the healthy control group was 34.4 years .The mean serum zinc levels in the erosive and non erosive lichen planus groups and control groups were 8.3 (1.15, 11.15 (0.92 and 15.74 (1.75 μg/dl respectively. The difference was statistically significant (p< 0.05. Conclusion: The serum zinc levels were decreased in patients with erosive oral lichen planus. This finding may probably indicate the promising role of zinc in development of oral lichen planus.

  19. 黄煌治疗口腔扁平苔癣案1则%A Successful Case of Oral Lichen Planus Treated by Professor Huang Huang

    Institute of Scientific and Technical Information of China (English)

    张薛光; 吕永赟; 黄煌

    2008-01-01

    口腔扁平苔癣(oral lichen planus,OLP)是一种慢性非感染性炎性疾病。由于尚不清楚其确切的病因和发病机制,目前尚没有特效疗法,同时本病还具有迁延反复与久治不愈的临床特点,并有一定的癌变率,给患者带来了较大的病痛和精神负担。黄煌教授临床中擅长应用经方治疗口腔黏膜病,对于本病亦有较好的临床疗效,兹选取其中1例介绍如下:

  20. The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus

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    Magdalena Kazanowska-Dygdała

    2016-02-01

    Full Text Available ABSTRACT Objective Helicobacter pylori infection is one of the most common bacterial infections in men. This gastrointestinal pathogen is closely related to gastritis, peptic ulcers, and the increased risk of gastric cancer. Numerous studies have indicated oral cavities as possible Helicobacter pylori reservoirs. Helicobacter pylori has been detected both in supragingival and subgingival plaques, and also in saliva. In addition, the relationship between lesions of oral mucosa and the presence of H. pylori has been evaluated and described in some studies. The aim of this study was to assess the presence of Helicobacter pylori DNA in the oral cavity of patients with oral leukoplakia and oral lichen planus. Material and Methods The study included 54 patients with oral leukoplakia, 72 with oral lichen planus lesions, and 40 healthy controls. The presence of Helicobacter pylori in oral cavity samples was analyzed using a single-step Polymerase Chain Reaction (PCR method. All patients underwent a periodontal examination and the following clinical parameters were collected: pocket depth, bleeding, and plaque indexes. The periodontal status was assessed using the Offenbacher classification. Results In most patients, pathological lesions were in typical sites on the buccal mucosa (leukoplakia in 88%, and oral lichen planus in 93% of patients. The DNA of the Helicobacter pylori was present in 20% of patients with leukoplakia and 23% of patients with lichen planus. We did not find the DNA of H. pylori in healthy controls. The periodontal status described by periodontal indices was worse in the investigated group than in the control group. Conclusion These findings suggest that the H. pylori presence in oral cavities may be related with leukoplakia and lichen planus oral lesions.

  1. A STUDY OF COMPARATIVE EFFEICIENCY OF ORAL MINI PULSE THERAPY VERSUS ORAL ACITRET IN IN GENARALISED LICHEN PLANUS

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    Guru Prasad

    2015-10-01

    Full Text Available BACKGROUND: Lichen planus is a chronic inflammatory disease that effects skin, mucous membranes, hair and nails. There are several drugs both topical and systemic for the treatment of lichen planus. AIMS AND OBJECTIVES: Present study was done to compare the efficacy between oral mini pulse therapy with betamethasone and with acetretin in the management of generalised lichen planus. MATERIALS AND METHODS: The study was carried out on patients who were clinically diagnosed as generalised lichen plan us, attending the outpatient department of dermatology, venereology and leprosy, King George hospital, affiliated to Andhra medical college, Vis h akhapatnam from November 2011 to December 2012. A total of 60 patients were included in study and divided into two equal groups. Group1 patients were treated with 0.1 mg/kg of oral betamethasone given on 2 consecutive days in a week till 8 weeks and tapered. Group 2 patients were treated with 0.5 mg/kg of acetretin for 8 weeks and tapered. INCLUSION CRITERIA: All pa tients of age group in between 11 - 60 years , of either sex, suffering f rom lichen planus of duration > 3 months, and women in group 2 who were in reproductive age group on two methods of contraception were included. EXCLUSION CRITERIA: Pregnant and lactating women, in Group 1: patients suffering from diabetes, hypertension, peptic ulcer disease, renal, hepatic, heart disease or tuberculosis, in Group 2: patients with abnormal lipid profile, diabetes, hypertension, renal, liver or heart disease were excluded. RESULTS: out of 60 patients enrolled in study, 2 patients from group 1 and 5 patients from group 2 were dropped from study and results were concluded. Majority of patients were in age group of 31 - 60 (78.3% with male to female ratio of 2.1:1.Group 1 patient s at the end of 8 weeks response was seen in 92.8%, with relapse rate of 15.38% after 6 months of follow up. Group 2 patients at end of 8 weeks response was seen in 72 % with relapse

  2. Erosive oral lichen planus with cutaneous involvement in a 7-year-old girl: a rare case report.

    Science.gov (United States)

    Moger, Ganapathi; Thippanna, Chandrashekar K; Kenchappa, Mallikarjun; Puttalingaiah, Vinuth D

    2013-01-01

    Lichen planus is a chronic autoimmune, mucocutaneous disease, which can affect the oral mucosa, skin, genital mucosa, scalp and nails, and commonly seen in adults. Childhood lichen planus is a rare entity, which is characterized by skin lesions with the oral involvement being extremely uncommon. There are only a few reports on this subject in the literature. Early and correct diagnosis with adequate management is very important to avoid further complications as it is a pre-malignant condition. Herewith, we report a seven-year-old girl having erosive oral lichen planus with cutaneous involvement, which responded well to the treatment. This is to add another case of lichen planus in a child and to emphasize its consideration in the differential diagnosis of oral mucosal red and white lesions in children.

  3. Lichen planus-like drug eruptions due to β-blockers: a case report and literature review.

    Science.gov (United States)

    Fessa, Chris; Lim, Penny; Kossard, Steve; Richards, Shawn; Peñas, Pablo Fernandez

    2012-12-01

    Lichen planus-like drug eruptions (LDE) can appear similar or identical to idiopathic lichen planus. We present a 45-year-old man with a widespread, violaceous, papular, generalized exanthema with histologic features of a lichenoid reaction, which subsequently resolved with the cessation of labetatol. We found 29 cases of previously reported β-adrenoceptor antagonist (β-blocker)-associated LDE. This is a relatively rare complication that may present as classic lichenoid papules indistinguishable from lichen planus and has a predilection for the limbs, chest, back, and oral mucosa. Histologically, there is a lichenoid infiltrate often with eosinophils. LDE may be due to drug cross-reactivity or as a result of a suppressed skin adrenergic system. Multiple potential medications in case studies and the inability to differentiate LDE from idiopathic lichen planus in cross-sectional association studies make any conclusive analysis difficult.

  4. A case of facial lentiginous lichen planus pigmentosus associated with Hashimoto’s thyroiditis and diabetes mellitus

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    Fadime Kilinc

    2015-10-01

    Full Text Available Lichen planus pigmentosus (LPP is an autoimmune, chronic and rare variant of lichen planus of unknown etiology that progresses with pigmentation. The condition is rarely observed concurrently with autoimmune diseases. In this case report, a diabetic male patient with speckled lentiginous lesions on the face, also diagnosed with concurrent autoimmune thyroiditis is presented due to the rarity of the condition and the morphological character of the lesions.

  5. Association between polymorphisms in interleukins and oral lichen planus

    Science.gov (United States)

    Shi, Quan; Zhang, Tong; Huo, Na; Huang, Yang; Xu, Juan; Liu, Hongchen

    2017-01-01

    Abstract Background: More and more studies have suggested that single-nucleotide polymorphisms (SNPs) in interleukin (IL) genes are correlated with an increased risk of developing oral lichen planus (OLP). However, these results were inconsistent. Therefore, the aim of this meta-analysis is to retrieve and comprehensively analyze all related clinical studies to investigate the association of ILs gene polymorphisms with the OLP risk. Methods: PubMed, Embase, and the Cochrane Library were searched for eligible studies to evaluate the association between IL polymorphisms and the OLP. The odds ratios (ORs) and 95% confidence intervals (CIs) from each study were pooled to estimate the strength of the association. Statistical analyses were performed by using STATA software. Results: In all 6 studies, including 4 SNPs (IL6-174G/C, IL10-592C/A, IL10-819C/T, and IL10-1082G/A), 362 OLP patients and 622 non-OLP control subjects from five different countries were investigated. As for the IL6-174G/C, IL10-819C/T, and IL10-1082G/A, no evidence was found to support the association between SNP and OLP susceptibility in any genetic models. However, as for IL10-592C/A, a significant relationship between them was identified in all of comparison models (C vs A: OR = 0.724, 95% CI = 0.585–0.897, P = 0.003; CC vs AA: OR = 0.447, 95% CI = 0.276–0.722, P = 0.001; AC vs AA: OR = 0.585, 95% CI = 0.387–0.883, P = 0.011; CC+AC vs AA: OR = 0.544, 95% CI = 0.365–0.809, P = 0.003; CC vs AA+AC: OR = 0.715, 95% CI = 0.515–0.994, P = 0.046). Conclusion: With the presently available evidence, this meta-analysis fails to show the statistical associations between IL6-174G/C, IL10-819C/T, and IL10-1082G/A and OLP susceptibility in any genetic models. However, the A allele and AA genotype in IL10-592C/A polymorphism may increase the risk of OLP. In the future, more well-designed studies with larger sample sizes are needed. PMID

  6. Comparative study of number and distribution of IgG+ cells in oral lichen planus and oral lichenoid lesions

    Directory of Open Access Journals (Sweden)

    Parichehr Ghalayani

    2009-01-01

    Full Text Available Background: Oral lichen planus is a common mucocutaneous disorder with unknown etiology. While current data suggest that oral lichen planus is a cell-mediated disease, differential diagnosis of this disease and oral lichenoid lesions is very problematic, both clinically and histopathologically. This study aimed to compare immunohistochemical features of these similar diseases. Methods: This was a descriptive-analytic study in which formalin-fixed and paraffin-embedded tis-sue sections of 30 oral lichen planus and 30 oral lichenoid lesions were immunohistochemically ana-lyzed for number and distribution of IgG + cells. A standard biotin-streptavidin procedure after anti-gen retrieval was used. Data were analyzed in SPSS software using Mann-Whitney U test. Results: There were some significant differences in distribution of IgG + cells among different loca-tions in oral lichen planus and also in oral lichenoid lesions separately; but the differences between distribution of IgG + cells between the two groups of oral lichen planus and oral lichenoid lesions were not significant. Conclusion: There was no significant difference in number and distribution of IgG + cells between the two groups. So, this study can suggest that location of IgG is similar in samples of oral lichen planus and oral lichenoid lesions and consequently, this marker cannot help us differentiate them from each other. Other markers can be analyzed in further studies in order to find an appropriate distinguisher between the two lesions.

  7. An autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155.

    Science.gov (United States)

    Terlou, Annelinde; Santegoets, Lindy A M; van der Meijden, Willem I; Heijmans-Antonissen, Claudia; Swagemakers, Sigrid M A; van der Spek, Peter J; Ewing, Patricia C; van Beurden, Marc; Helmerhorst, Theo J M; Blok, Leen J

    2012-03-01

    Vulvar lichen sclerosus and lichen planus are T-cell-mediated chronic skin disorders. Although autoimmunity has been suggested, the exact pathogenesis of these disorders is still unknown. Therefore, the aim of the current study was to investigate the molecular and immunological mechanisms critical to the pathogenesis of vulvar lichen sclerosus and lichen planus. By using gene expression profiling and real-time RT-PCR experiments, we demonstrated a significantly increased expression of the pro-inflammatory cytokines (IFNγ, CXCR3, CXCL9, CXCL10, CXCL11, CCR5, CCL4, and CCL5) specific for a Th1 IFNγ-induced immune response. In addition, BIC/microRNA-155 (miR-155)--a microRNA involved in regulation of the immune response--was significantly upregulated in lichen sclerosus and lichen planus (9.5- and 17.7-fold change, respectively). Immunohistochemistry showed a significant T-cell response, with pronounced dermal infiltrates of CD4(+), CD8(+), and FOXP3(+) cells. In conclusion, these data demonstrate an autoimmune phenotype in vulvar lichen sclerosus and lichen planus, characterized by increased levels of Th1-specific cytokines, a dense T-cell infiltrate, and enhanced BIC/miR-155 expression.

  8. Oral findings in patients with primary Sjögren's syndrome and oral lichen planus - a preliminary study on the effects of bovine colostrum-containing oral hygiene products

    DEFF Research Database (Denmark)

    Pedersen, A.M.; Torpet, L.A.; Reibel, J.

    2002-01-01

    Primary Sjögren's syndrome, oral lichen planus, bovine colostrum, saliva, xerostomia, oral mucosa......Primary Sjögren's syndrome, oral lichen planus, bovine colostrum, saliva, xerostomia, oral mucosa...

  9. A CLINICAL STUDY ON THE TREAMENT OF ORAL LICHEN PLANUS WITH MICROWAVE%微波热凝治疗口腔扁平苔藓近期临床研究

    Institute of Scientific and Technical Information of China (English)

    王静; 刘静明; 王力敏

    2001-01-01

    Objective:To investigate the effectives of microwave on the treament of oral lichen planus.Methods:We treated 27 cases of oral lichen planus with microwave.Results:Eighteen patients were cured with microwave,7 cases improved and useless in cases.Conclusion:Microwave is useful to treat oral lichen planus.%目的:观察微波热凝治疗口腔扁平苔藓近期临床效果.方法:应用微波治疗口腔扁平苔藓(OLP)27例.并追踪观察临床效果.结果:口腔扁平苔藓经微波热凝治疗.痊愈18例,有效7例,无效2例.结论:微波热凝治疗口腔扁平苔藓近期临床效果满意.

  10. Clinical Assessment of the Efficiency of Low Level Laser Therapy in the Treatment of Oral Lichen Planus

    Directory of Open Access Journals (Sweden)

    Hanaa M. Elshenawy

    2015-10-01

    Full Text Available BACKGROUND: Oral lichen planus (OLP is a chronic inflammatory disease of the oral mucosa of uncertain etiology. AIM: To evaluate the effect of using low level laser therapy (LLLT (970 nm Siro laser Advance for the treatment of symptomatic (OLP. SUBJECTS AND METHODS: The present study was conducted on ten patients suffering from persistent oral lichen planus (OLP.Patients were treated with diode laser (970nm for the symptomatic relief of pain and burning sensation. The patients were assessed before, during and after the completion of the laser treatment which was done twice weekly for two successive months with maximum of ten sessions. The assessment was performed using visual analogue scale (VAS and clinical investigation for each patient. RESULTS: Detailed significant reduction in lesion size and showed complete remission of burning sensation and pain. No reported complications or therapy side effects were observed in any of the treated patients. CONCLUSION: Diode laser therapy seems to be an effective adjunctive treatment modality for relieving pain and clinical symptoms of OLP.

  11. Contact hypersensitivity to mercury in amalgam restorations may mimic oral lichen planus.

    Science.gov (United States)

    Camisa, C; Taylor, J S; Bernat, J R; Helm, T N

    1999-03-01

    Oral lichenoid lesions caused by hypersensitivity to mercury in amalgam fillings may mimic oral lichen planus on clinical and histologic examination. A positive patch test reaction to more than one mercurial allergen increases confidence in the diagnosis and justifies the removal and replacement of all amalgam fillings with those made of other materials. A complete remission may be expected about 3 months after the last amalgam filling is removed.

  12. he role of vascular endothelial growth factor in the pathogenesis of lichen planus and psoriasis

    OpenAIRE

    Artemina Е.М.; Shtoda U.М.; Slesarenko N.A.; Bakulev A.L.; Utz S.R.

    2014-01-01

    The goal: to investigate the process of angiogenesis by determining the level of vascular endothelial growth factor (VEGF) in the blood serum of patients with lichen planus (CPL) and psoriasis. Material and Methods. The study included 50 patients with CPL, 62 patients with psoriasis and 36 were in the control group of healthy individuals. All of the participants were to determine the level of VEGF in a blood serum before treatment. Results. Patients with CPL had an increase in the level of VE...

  13. Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus

    Directory of Open Access Journals (Sweden)

    2004-08-01

    Full Text Available Lichen planus is a mucocutaneous disease of inflammatory nature and unknown etiology. It is characterized by a cell-mediated immunological response to induced antigenic change in skin and/or mucosa. The possible malignant transformation of lichen planus remains a subject of controversial discussions in the literature. hMSH2 is one of the human DNA mismatch repair (hMMR genes and it plays an important role in reducing mutation and maintaining genomic stability. hMSH2 alterations have been reported in oral squamous cell carcinoma and there are evidences suggesting the association between oral lichen planus and squamous cell carcinoma. In this study, we aim to investigate the immunolocalization of hMSH2 protein in oral lichen planus compared to oral normal mucosa epithelium. We examined the expression of hMSH2 protein by immunohistochemistry in twenty-six cases of oral lichen planus. Clinically, 12 of them were categorized into reticular subtype and 14 were atrophic/erosive. Ten cases of normal mucosa were added to the control group. Results showed that the percentage of positive cells to hMSH2 was smaller in reticular (46.54%; p=0,006 and atrophic/erosive (48.79%; p=0,028 subtypes of oral lichen planus compared to normal mucosa (61.29%. The reduced expression of hMSH2 protein in oral lichen planus suggests that this lesion is more susceptible to mutation and therefore facilitate the development of oral squamous cell carcinoma.

  14. Quantitative immunohistochemical assessment of blood and lymphatic microcirculation in cutaneous lichen planus lesions.

    Science.gov (United States)

    Výbohová, Desanka; Mellová, Yvetta; Adamicová, Katarína; Adamkov, Marián; Hešková, Gabriela

    2015-06-01

    Latest advances have brought to light the hypothesis that angiogenesis and lymphangiogenesis are tightly connected to some chronic inflammatory diseases. The present study focuses on immunohistochemical assessment of the quantitative changes in the blood and lymphatic microcirculatory bed in common chronic dermatosis - cutaneous lichen planus. Double immunohistochemistry with CD34 and podoplanin antibodies was used to detect blood and lymphatic endothelium, while anti-human VEGF was used for the observation of a key angiogenesis and lymphangiogenesis inducer. Morphometric analysis was performed with QuickPhoto Micro image analysis software. Results confirmed statistically significant enlargement of both the blood and lymphatic microcirculatory beds. Compared to healthy skin, cutaneous lichen planus lesions revealed 1.6 times enlarged blood microcirculatory bed and 1.8 times enlarged lymphatic microcirculatory bed. Vascular endothelial growth factor (VEGF) expression in lesional skin was significantly higher in the epidermis (19.1 times increase) than in the dermis (10.3 times increase). These findings indicate a tight association of angiogenesis and lymphangiogenesis with the pathogenesis of cutaneous lichen planus.

  15. Lichen planus-like eruption resulting from a jellyfish sting: a case report

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    Ghosh Sudip Kumar

    2009-07-01

    Full Text Available Abstract Introduction Contact with a jellyfish can cause a wide variety of conditions, ranging from cutaneous eruption to fatal cardiovascular and respiratory collapse. Cutaneous features can be both acute and chronic. We report a case of persistent lichen planus-like eruption in a young boy after a jellyfish sting, a hitherto unreported occurrence. Case presentation A 15-year-old boy presented with multiple lichen planus-like violaceous papules over the lower part of his left thigh on the anterior aspect and also over the patellar region. He had a history of a jellyfish sting over his lower limbs incurred while bathing in the sea four weeks prior to presentation. Histopathology revealed a predominantly perivascular mononuclear cell infiltrate immediately beneath the dermoepidermal junction underneath the hyperplastic epidermis. The lesions significantly subsided with topical corticosteroid application. Conclusion This case report demonstrates a new variant of chronic cutaneous change following a jellyfish sting. We report it because of its uniqueness and we believe that physicians should be aware of the possibility of an aquatic animal-induced disease when dealing with lesions with lichen planus-like morphology.

  16. Vulvovaginal gingival lichen planus: report of two cases and review of literature

    Science.gov (United States)

    LUCCHESE, A.; DOLCI, A.; MINERVINI, G.; SALERNO, C.; DI STASIO, D.; MINERVINI, G.; LAINO, L.; SILVESTRE, F.; SERPICO, R.

    2016-01-01

    SUMMARY Purpose Oral Lichen Planus (OLP) is a chronic inflammatory disease of skin and mucous membranes. Approximately 20% of women with oral lichen planus develops lesions in the genital mucosa. In 1982, Pelisse described a special form of lichen planus (LP), which consists of a triad of symptoms: vulval, vaginal and gingival (VVG)-LP lesions. Aim of the present report is to report two new cases and review the international literature. Material and methods Two cases of VVG-LP are reported and a review of recent literature is performed. Results The onset of erosive or ulcerative mouth lesions may precede or follow by months or even years the onset of vulvovaginal lesions. Vaginal agglutination is associated with the postmenopausal state in conjunction with a dermatologic condition. Intra-lesional corticosteroids have a role in localized chronic ulceration, while systemic therapies such as corticosteroids, azathioprine, mycophenolate mofetil, hydroxychloroquine, ciclosporin, methotrexate, retinoids, thalidomide and photo chemotherapy have been used in more severe cases with varying success. Conclusions VVG-LP is rather a rare condition and has been documented in the literature mainly in the form of case reports. Lack of a precise diagnostic criteria of VVG-LP depends on the specialists. PMID:28042431

  17. A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible

    Science.gov (United States)

    Soo, Joanne; Kokosis, George; Ogilvie, Michael; “Sara” Jiang, Xiaoyin; Powers, David B.; Rocke, Daniel J.

    2016-01-01

    Summary: Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy. She then developed a recurrence of the mandibular alveolar ridge. The patient was successfully treated with a composite resection including a segmental mandibulectomy, buccal mucosa resection, partial glossectomy, and ipsilateral neck dissection. This was reconstructed with a free fibula osteo-septo-cutaneous flap. Mandibular OSCC is a rare complication of OLP with few reports on effective reconstructive interventions. The case represents the youngest reported patient with mandibular OSCC arising in the context of OLP and highlights the utility of the free vascularized fibula graft in the treatment of these patients. PMID:28293492

  18. Comparison of Two Corticosteroids Mouthwashes in Treatment of Symptomatic Oral Lichen Planus

    Directory of Open Access Journals (Sweden)

    Ahadian H.

    2012-06-01

    Full Text Available Statement of Problem: Oral Lichen Planus (OLP is a common chronic inflam-matory mucocutaneous disease and has different types. If they are symptomatic, they must be treated. Corticosteroid, especially in topical form, is commonly used.Purpose: The purpose of this study was to compare the therapeutic effects of two corticosteroid mouthwashes on treatment of symptomatic OLP.Materials and Method: The participants of this single-blind study were 44 symptomatic OLP patients. They included 27 females and 17 males. They were randomly divided into two groups and were given drug A (Dexamethasone 0.1% or B (Triamcinolone acetonide 0.2% for four weeks. Extension of lesions (mm2 and severity of symptoms (based on Visual Analogue Scale were recorded before and after treatment (weeks 1, 2, 4. Finally, SPSS 12 was used and Man-Whitney test was run to analyze the data.Results: In both groups extension of lesions and burning sensation decreased significantly during the four weeks of treatment. There was no statistically significant difference between the two groups. However, Dexamethasone 0.1% was more efficacious, in the fourth week, in reducing the size of lesions than Triamcinolone acetonide 0.2% ( p = 0.02. Conclusion: Both mouth washes were useful in diminishing pain and decreasing the size of lesions. However, Dexamethasone 0.1% was recommended for treat-ment of OLP because it was more efficacious than Triamcinolone acetonide 0.2%.

  19. 扁平苔藓药物治疗进展%Advances in the drug treatment of lichen planus

    Institute of Scientific and Technical Information of China (English)

    周勐; 简晓清

    2013-01-01

    Lichen planus ( LP ) is a chronic or subacute inflammatory dermatosis of the mucocutaneous surfaces that can present with a variety of clinical manifestations. The pathogenesis of LP is unknown and LP is difficult to cure. A variety of drugs are used to treat LP, in addition to commonly used drugs such as steroid hormones, retinoic acid, immunosuppressant, etc. There are sul-fasalazine, levamisole, biological agents and other drugs. In this paper, the latest research on the LP drug therapy are reviewed, in order to provide drug information and treatment guidance for the correct treatment of LP.%扁平苔藓(lichen planus,LP)是慢性或亚急性炎症性疾病,病因未明,治疗较困难.现在有多种药物用于治疗LP,除类固醇激素、维甲酸类、免疫抑制剂等常用药物外,还有柳氮磺吡啶、左旋咪唑、生物制剂等药物.文中就近年来治疗LP的药物研究进展做一综述,为正确治疗LP提供药物信息和指导.

  20. Serum Level of Vascular Endothelial Growth Factor in Patients with Different Clinical SubtypeS of Oral Lichen Planus

    Directory of Open Access Journals (Sweden)

    Maryam Mardani

    2012-12-01

    Full Text Available Background: Oral lichen planus is a chronic inflammatory disease with a poorly understood etiology. The role of angiogenesis in the development of different chronic inflammatory diseases is of great concern. Vascular endothelial growth factor (VEGF is an important regulator of angiogenesis. We aimed to evaluate the serum level of VEGF in patients with oral lichen planus compared with normal individuals and consider its clinical significance.Methods: In this case-control study, 36 serum samples from patients diagnosed with oral lichen planus admitted to the Oral Medicine Department of the School of Dentistry at Shiraz University of Medical Sciences (14 men, 22 women, mean [±SD] age: 38.8 [±6.07] years and 23 serum samples from healthy individuals (9 men, 14 women, mean [±SD] age: 38.7 [±4.9] years were collected. VEGF concentration was measured using the ELISA method. The Mann-Whitney test was used for statistical analysis.Results: The serum VEGF level was significantly higher in patients with oral lichen planus compared with the healthy controls (112.97 [±63.2] vs. 66.21 [±56.2] ngr/ml, P<0.001. A similar difference was also observed between the two types of oral lichen planus, being more pronounced in the erosive form (P<0.001.Conclusion: Serum VEGF can be used as a useful and suitable marker to scrutinize the disease activity.

  1. Comparison of seropositivity of HCV between oral lichen planus and healthy control group in Hamedan province (west of Iran

    Directory of Open Access Journals (Sweden)

    Ahmad Reza Mobaien

    2011-10-01

    Full Text Available Background: Lichen planus is an idiopathic inflammatory disease of the skin, nail, hair and mucous membranes. Oral lichen planus (LP is a chronic inflammatory condition that affects the oral mucous membranes with a variety of clinical presentations. Various etiologies include HCV suggested for LP, and the aim of this study was comparison of seropositivity of HCV in LP patients and control group. Methods: All oral LP patients that were referred to dermatology clinic of farshchian hospitalwere entered in the study. Five cc of clot blood was taken from each patient and tested for anti-HCVand when anti-HCV tested positive another 2cc clot bloodwas taken for HCV-Rt-PCR test. The results were analyzed with SPSS 16. Results: This prospective cross-sectional study was conducted on 30 oral lichen planus patients [males 13(43.3% females 17(56.7%] with mean ages of 46±13.7years and 60 healthy individual [males 26(43.3% females 34(56.7%]. There was no oral lichen planus patients who had anti-HCV positive whiles 2 males(3.3% of healthy group had anti-HCV positive which was confirmed by HCV-Rt-PCR. Conclusions: This study showed that there is no correlation between seropositivity of HCV and oral lichen planus in our patients in the west of Iran.

  2. Lichen planus and hepatitis C virus infection%扁平苔藓和丙型肝炎病毒

    Institute of Scientific and Technical Information of China (English)

    丁媛; 普雄明

    2009-01-01

    Lichen planus is an inflammatory disease of unknown origin with an overall prevalence of 0.5% to 2% in general population. It has been considered as an autoimmune disease. Hepatitis C virus infection is reported to be associated with many extrahepatic manifestations, including dermatologic condition such as lichen planus. This review summarizes the relation between lichen planus and hepatitis C virus infection, as well as the mechanism through which hepatitis C virus causes the development of lichen planus, which may offer new insights into the clinical treatment and early diagnosis of hepatitis C virus-associated lichen planus.%扁平苔藓是一种原因不明的炎症性皮肤病,其患病率为0.5%~2%.目前认为,扁平苔藓可能是一种自身免疫性疾病.丙型肝炎病毒被证明其伴随着一系列肝外表现,包括扁平苔藓,为此,综述扁平苔藓和丙型肝炎病毒的关系,以及病毒感染如何导致扁平苔藓的发生,从而为扁平苔藓合并丙型肝炎病毒感染的临床治疗及早期诊断提供一种思路.

  3. Relevance of psychosocial factors to quality of life in oral cancer and oral lichen planus: a prospective comparative study.

    Science.gov (United States)

    Rana, Madiha; Kanatas, Anastasios; Herzberg, Philipp Y; Gellrich, Nils-Claudius; Rana, Majeed

    2015-09-01

    We can improve our understanding of how patients cope with oral squamous cell carcinoma (SCC) by making a comparison with their processes of coping and those used in other conditions. We have therefore compared quality of life (QoL), severity of symptoms, coping strategies, and factors that influence coping between patients with oral SCC and those with oral lichen planus. We asked 104 patients with oral SCC and 51 with oral lichen planus to complete questionnaires about their coping strategies, social support, locus of control, spirituality, QoL, and severity of symptoms. The outcome was that patients with oral SCC were far more likely to resort to coping strategies such as depressive coping, distraction, and self-motivation. The groups also differed regarding QoL and severity of symptoms. Patients with oral SCC had a poorer QoL and higher depression scores, whereas patients with oral lichen planus had better scores in the social support and spirituality categories. Patients with oral SCC generally had more distress than those with oral lichen planus. Not only did the former resort to depressive coping strategies, but they also had poorer QoL and higher values for depression. For the patients with oral lichen planus, social support and spirituality were protective, whereas they were associated with distress by patients with oral SCC.

  4. Anti-angiogenic therapy (bevacizumab) in the management of oral lichen planus.

    Science.gov (United States)

    Mahmoud, Maha M; Afifi, Marwa M

    2016-04-01

    Oral lichen planus (OLP), a mucocutaneous chronic inflammatory disease, is conventionally managed using topical corticosteroid therapy. Given the fact that OLP is strongly linked to angiogenesis, anti-angiogenic drugs, such as bevacizumab, might be introduced as an alternative treatment for contraindicated, non-responsive patients. The aim of the present study was to report the short-term effectiveness and safety of intralesional bevacizumab injection in the management of atrophic/erosive OLP. A case series study was conducted in patients with atrophic/erosive OLP in the buccal mucosa, assigned to receive either 2.5 mg of bevacizumab, by intralesional injection (n = 20, test), or topical 0.1% triamcinolone acetonide ointment (n = 20, control). The size, score, and pain intensity of the lesions were assessed pre- and post-treatment. Tissue biopsies were collected for histopathologic, immunohistochemical, and ultrastructural examination. After 1 wk, the test group had significant reductions both in lesion seize and in pain scores compared with controls. A marked decrease in vascular endothelial growth factor (VEGF) and interleukin-8 immunoexpression was noted in tissue biopsies from bevacizumab-treated lesions compared with control lesions. Furthermore, ultrastructural examination of OLP tissue specimens revealed significant healing signs associated with bevacizumab treatment. Short-term data suggest that intralesional bevacizumab injection effectively and safely achieved resolution of atrophic/erosive OLP lesions without disease exacerbations during a 3-month follow-up period.

  5. Oral lichen planus versus oral lichenoid reaction: Difficulties in the diagnosis

    Directory of Open Access Journals (Sweden)

    Do Prado Renata

    2009-01-01

    Full Text Available Lichen planus (LP is a mucocutaneous disease with well-established clinical and microscopic features. The oral mucosa and skin may present clinical and microscopic alterations similar to those observed in LP, called lichenoid reactions (LRs, which are triggered by systemic or topical etiological agents. The difficulties faced to establish the differential diagnosis between the two pathologies were investigated in the literature. It was observed that the etiology of LP is still under discussion, with a tendency to self-immunity, while the etiology of LRs is related to the contact with specific agents, such as metallic restorative materials, resins, and drugs, allowing the establishment of a cause-effect relationship. In this case, the disease is caused by the antigen fixation in the epithelial cells, which are destructed by the immune system. Based on these data, protocols are suggested for this differentiation. The important role played by the integration between the clinician and the oral pathologist in the diagnostic process is highlighted. The treatment of LP comprises mainly the utilization of corticosteroids and the LR is treated by removal of the causal factor. Differentiation between the two diseases allows an effective and correct therapeutic approach.

  6. Therapeutic hotline. Effectiveness of the association of cetirizine and topical steroids in lichen planus pilaris--an open-label clinical trial.

    Science.gov (United States)

    d'Ovidio, Roberto; Rossi, Alfredo; Di Prima, Tiziana Maria

    2010-01-01

    Lichen planus is considered a T cell-mediated immunological disease. Even mast cells may contribute to the pathogenesis of the disease. Keratinocytes of the basal layer of the skin and/or the hair follicle may represent the "target/victim" of an immune aggression, determining the destruction of the hair follicle and thus scarring alopecia. Therefore, there is a compelling urgency for effective treatment of this potentially disfiguring dermatosis. Our data provide a further therapeutic opportunity: the use of an antihistaminic drug--cetirizine (CTZ)--in an "anti-inflammatory" regimen. We propose the use of CTZ at the dosage of 30 mg/daily. Twenty-one patients affected by lichen planus pilaris (LPP) of the scalp have been treated. Topical application of steroids has been coadministered in all cases during the therapy. Clinical effects, in the sense of stabilization with cessation of the inflammation (erythema, follicular hyperkeratosis, loss of anagen hair), were achieved in all patients but three. One patient developed cardiac arrhythmia after 3 months of successful treatment and dropped out. Our cases indicate that a combined therapy of topical steroid with CTZ can be a safe and effective choice even in severe cases of lichen planus pilaris, so often refractory to the therapy. © 2010 Wiley Periodicals, Inc.

  7. Zosteriform lichen planus after herpes zoster: report of a new case of Wolf's isotopic phenomenon and literature review.

    Science.gov (United States)

    Lora, Viviana; Cota, Carlo; Kanitakis, Jean

    2014-11-15

    The Wolf's isotopic phenomenon corresponds to the occurrence of a skin disease at a body site affected previously by a different, already healed dermatosis. We report a 74-year-old man who presented with a zosteriform eruption consisting of erythematous-scaly, slightly pruritic papules on the right flank some weeks after herpes zoster (HZ) had healed on the same area. Histologic examination showed typical changes of lichen planus, confirming the diagnosis of post-HZ zosteriform lichen planus (ZLP). The lesions regressed with topical steroid treatment. Zosteriform lichen planus (ZLP) is one example of Wolf's isotopic phenomenon appearing after HZ. So far, only 17 cases have been reported in the literature. The precise pathogenesis of ZLP is not well known, although persisting viral proteins could be responsible for the hypersensitivity reaction. We review and discuss the salient clinicopathologic features of this rare entity based on a thorough literature review.

  8. 口腔扁平苔藓的治疗研究%Clinical Effect of Treatment for Oral Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    郭成庆; 王丽红

    2013-01-01

    Objective To observe and analysis the clinical effect of treatment for oral lichen planus. Methods A total of 68 patients with histologically and clinically conifrmed OLP were collected,the therapeutic effect were recorded and analyzed. Sixty-eight cases of patients with oral lichen planus were divided into treatment group (34 cases) and control group (34 cases) according to the different method of treatment. The control group was treated with conventional treatment,the observation group was treated with integrated traditional Chinese and western medicine and the clinical effect between two groups was compared. Results Cure rate and efifciency of the treatment group than the control group. The difference in the total effective rate between two groups was signiifcant(P<0.05). Conclusion The integrated traditional Chinese and western medicine for oral lichen planus shows a complementation effect and it is beneifcial to the restoration of oral mucosa cell. Depending on systemic immunoregulatory function, it can consolidate clinical effect and reduce recurrence.It is worthy to clinical.%目的对口腔扁平苔藓的临床特点及治疗方法进行探讨和分析。方法回顾性分析了经我院确诊并给予治疗的68例患有口腔扁平苔藓的患者。68例患者随机分为两组,对照组及治疗组各34例,对照组采用西医常规治疗,治疗组在西医治疗的基础上均采用中药方剂进行治疗,比较两组的疗效。结果痊愈率及有效率治疗组均优于对照组,两组疗效有显著性差异(P<0.05)。结论中药方剂配合西医常规治疗可显著提高口腔扁平苔藓的治愈率,方法安全可靠,无副作用,值得临床推广。

  9. The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients

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    Othman, Nagwa-Abdelhamid; Shaker, Olfat-Gamil; Abd-Elmoniem, Wessam; Eldin, Amany-Mohy; Fakhr, Mariam-Yehia

    2016-01-01

    Background Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease with a multifactorial etiology. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+T cells trigger apoptosis of the basal cells of oral epithelium. Various treatment regimens have been employed for management of symptomatic OLP. This study was carried out to evaluate the effect of topical steroids as well as laser on the clinical signs and symptoms detected by reticular, atrophic, erosive score (RAE score) and tumor necrosis factor- α (TNF-α) level in the serum of patients with symptomatic OLP. Material and Methods The study was conducted on twenty-four patients (18 females and 6 males) with symptomatic OLP that were allocated into two groups. Each included twelve patients. The first group treated either with diode laser (970nm SIROLaser Advance class IIIb, SIRONA The Dental Company, Germany) twice weekly with maximum of ten sessions while the second group were treated with topical corticosteroids (0.1% triamcinolone acetonide orabase, Kenacort-A Orabase Pomad, DEVA HOLDING A.Ș, Istanbul, Turkey) for four weeks. Results Corticosteroids group showed less clinical signs and symptoms of reticular, atrophic, erosive RAE score (p=0.02) and TNF-α serum level (p=0.028) than diode laser group with no reported therapy side effects or complications in any of the treated patients. Conclusions Topical steroids reduce pain, reticular, atrophic, erosive RAE score and TNF-α serum level more than laser treatment. Moreover, laser treatment can be used as an alternative treatment when steroids are contraindicated for the treatment of symptomatic OLP. Key words:Oral lichen planus, diode laser, topical steroid, RAE score, TNF-α. PMID:27957272

  10. Erosive vulval lichen planus--a diagnosis not to be missed: a clinical review.

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    Lewis, F M; Bogliatto, F

    2013-12-01

    Lichen planus is one of the inflammatory dermatoses that have a predilection for the genital mucosa, and the erosive type is particularly important. This can also affect other mucosal sites and scarring may occur, leading to significant symptoms and an effect on quality of life for patients. There is often a delay before the correct diagnosis is made and appropriate treatment instituted. This clinical review covers the clinical features and management options for this important disease and emphasises the need for a multi-disciplinary approach.

  11. Clinical and Laboratory Findings of a Group of Iranian Patients with Oral Lichen Planus

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    Darvishpoor Kakhki H.

    2012-03-01

    Full Text Available atement of Problem: Lichen planus (LP is a chronic disease that affects skin and mucous membranes. Lesions of oral lichen planus (OLP can persist for a long time. Varying prevalence rates of oral lichen planus have been reported in different parts of the world, while information regarding the epidemiology of this disease in Iran is incomplete.Purpose: This study was designed to evaluate the characteristics of oral lichen planus in a group of Iranian patients and compare the results with similar conducted studies in other populations. Materials and Method: In this descriptive study data were collected from charts of 158 patients In Kerman, Iran (1997-2005 over 8 consecutive years. For each patient, age at presentation, gender, chief complaint, duration of chief compliant, previous treatment, current medications, skin involvement and a complete medical history has been recorded. A number of possible etiologic factors and possible presence of diabetes or liver disease also analyzed. Laboratory evaluations consisted of glucose tolerance test (GTT and liver function tests (LFT. This data were analyzed by SPSS version 12 statistical software. Results: The mean age of study population was 41.16 years. Subjects were predominantly female (65.1%. Liver function tests (LFT were abnormal in 19.6% of cases. Disturbance of glucose metabolism and fasting blood sugar was also higher than normal limit in10.8% and 2.9 % of cases respectively. Atrophic-erosive lesions were found in 17 of the cases. In 50 patients the lesions were exclusively keratotic and in 91 the lesions were atrophic-erosive and keratotic. Most oral lesions were multifocal (88.6%, with the buccal mucosa being the most common location in each clinical form (87.3%. Duration of oral lesions ranged from 0.4 to 20 years with a mean of 1.54 year. Conclusion: This study showed that epidemiological and clinical features of the disease in Kerman are similar to those mentioned in literature. Also, in

  12. A retrospective clinicopathological study on oral lichen planus and malignant transformation: Analysis of 518 cases

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    Shen, Zheng Yu; LIU Wei; Zhu, Lai Kuan; Feng, Jin Qiu; Tang, Guo Yao; Zhou, Zeng Tong

    2012-01-01

    Objective: To investigate the epidemiological and clinical characteristics of a relatively large cohort of patients with oral lichen planus (OLP) from eastern China. Study design: A total of 518 patients with histologically confirmed OLP in a long-term follow-up period (6 months-21.5 years) were retrospectively reviewed in our clinic. Results: Of the 518 patients, 353 females and 165 males were identified. The average age at diagnosis was 46.3 years (range 9-81 years) with the buccal mucosa b...

  13. Oral Lichen Planus: Clinical Features, Etiology, Treatment and Management; A Review of Literature

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    Marzieh Boorghani

    2010-03-01

    Full Text Available Lichen planus is a chronic inflammatory mucocutaneous disease. Mucosal lesions are classified into six clinical forms and there is malignant potential for two forms of OLP; therefore, follow-up should be considered. There are many unestablished etiological factors for OLP and some different treatment modalities are based on etiology. The aims of current OLP therapy are to eliminate mucosal erythema and ulceration, alleviate symptoms and reduce the risk of oral cancer. We have used review papers, case reports, cohort studies, and case-and-control studies published from 1985 to 2010 to prepare this review of literature.

  14. p53 expression in oral lichenoid lesions and oral lichen planus.

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    Arreaza, A; Rivera, H; Correnti, M

    2015-01-01

    The aim of this article was to compare the expression of p53 protein in oral lichen planus (OLP) and oral lichenoid reaction (OLR). The study population consisted of 65 patients--31 diagnosed with OLP and 34 with OLR. The results showed more p53 positive cases in the OLP group than in the OLR group. However, the difference between the 2 groups was not statistically significant (P = 0.114). The most common immunolocalization was observed at the basal cell layer. Due to the chance of potential future malignancy, follow-up for all cases is recommended.

  15. GAMBARAN KLINIK DAN LATAR BELAKANG PASIEN DENGAN DIAGNOSIS KLNIK SEBAGAI LICHEN PLANUS DI POLI PENYAKIT MULUT RSCM DAN RSGM

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    Sri Tjahjani Sumantri

    2015-08-01

    Full Text Available Lichen planys is disorder of the skin and mucous membrane that presenting pruritic, purple and polygonal papules. Oral lesions may persist for years and with clinical appearance that sometimes very ocnfusing. In most cases, oral lesions are present as white, reticulated or natelike areas involving the mucosa. These lesions are characteristic and called Wickham's striae. This paper presented some cases with lesions that resembled oral lichen planus.

  16. EXTRACORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF TYPICAL AND ATYPICAL LICHEN PLANUS RUBRUM

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    A. V. Molochkov

    2016-01-01

    Full Text Available Background: Lichen planus rubrum (LPR belongs to the group of papulosquamous dermatoses. Pathophysiology of this most common lichenic dermatosis is related to autoimmune destruction of basal keratinocytes. Treatment of LPR includes systemic corticosteroids, cytotoxic agents, immunosuppressants, aromatic retinoids, PUVA-therapy, as well as biological preparations (rituximab, efalizumab, which all are insufficiently effective and associated with multiple side effects and complications. Aim: To evaluate efficacy of extracorporeal photochemotherapy (EPCT in generalized typical and atypical LPR. Materials and methods: We performed a prospective active-controlled cohort study. Thirty three patients with different types of LPR treated with EPCT were divided into 2 groups. Group 1 included 19 patients with typical generalized (including subacute and chronic LPR, group 2, 14 patients with atypical (pigmented, follicular, hypertrophic, erosive ulcerated, vulvovaginal/ gingival syndrome LPR. At 2 hours before a EPCT session patients were administered 8-methoxypsoralen, then mononuclear cells were isolated with a cell separator Haemonetics MCS+ and treated with UV A radiation (at a wavelength from 320 to 400  nm, then monocyte mass was reinfused to the patient. The treatment course consisted of 4  sessions performed every other day. Results: Positive clinical effect and satisfactory tolerability of EPCT were demonstrated in all 33 patients. In patients with generalized subacute typical LPR, EPCT promoted activation of natural immunosuppressive mechanisms (there was no correlation between CD8+ and HLA-DR+ , as well as between CD8+ and CD11b+: r=0.52 (р>0.05 and r=0.35 (р>0.05, respectively. In patients with generalized chronic LPR the treatment led to restoration of immune tolerance to genuine body antigens (correlation between CD16+ and CD11b+ was preserved and correlation between CD16+ and HLA-DR+ was lower: r=0.77 (p<0.05 and r=0.62 (p>0

  17. Demographic and clinical profile of oral lichen planus: A retrospective study

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    Anita D Munde

    2013-01-01

    Full Text Available Introduction: Oral lichen planus (OLP is a relatively common inflammatory mucocutaneous disorder that frequently involves the oral mucosa. The clinical presentation of OLP ranges from mild painless white keratotic lesions to painful erosions and ulcerations. An important complication of OLP is the development of oral squamous cell carcinoma, which led the World Health Organization (WHO to classify OLP as a potentially malignant disorder. The demographic and clinical characteristics of OLP have been well-described in several relatively large series from developed countries, whereas such series from developing countries are rare. Objective: The objective of this retrospective study was to investigate the epidemiological and clinical characteristics of 128 OLP patients in rural population of India. Materials and Methods: In this study, the diagnostic criteria proposed by van der Meij et al. in 2003 based on the WHO definition of OLP were used to identify cases. Results: In 128 patients, M:F ratio was 1.61:1. The buccal mucosa was the most common site (88.20%. White lichen was seen in 83.59% and red lichen in 16.40% cases. Reticular type of OLP was the most common form (83.5% followed by erosive (15.6% and atrophic OLP (0.78%. The incidence of systemic diseases included hypertension (11%, diabetes mellitus (2.4%, and hypothyroidism (0.78%. Histopathologically epithelial dysplasia was present in 4 cases. Conclusion: Most of the characteristics are consistent with previous studies with differences in few. Lichen planus is a chronic disease where treatment is directed to control of symptoms. Long-term follow-up is essential to monitor for symptomatic flare ups and possible malignant transformation.

  18. Twenty-nail dystrophy (trachyonychia) caused by lichen planus in a patient with alopecia universalis and ichthyosis vulgaris.

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    Taniguchi, S; Kutsuna, H; Tani, Y; Kawahira, K; Hamada, T

    1995-11-01

    A 7-year-old girl with alopecia universalis had dystrophy of all 20 nails. A nail biopsy specimen disclosed features of lichen planus. The patient also had ichthyosis vulgaris and hypogammaglobulinemia. We are not aware of any previous reports of these associations, which we believe to be noncoincidental.

  19. Comparison of the narrow band UVB versus systemic corticosteroids in the treatment of lichen planus: A randomized clinical trial

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    Fariba Iraji

    2011-01-01

    Conclusions: Overall, the results of our study and other previous studies showed that NBUVB may be regarded as an effective treatment for generalized cutaneous lichen planus. This treatment may be especially utilized when there is contraindication for systemic corticosteroids or other immunosuppressive drugs.

  20. Reticulate Pigmentation Associated with Scarring Alopecia in an Elderly Woman: An Unusual Manifestation of Lichen Planus Pigmentosus

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    Sharma, Vinod Kumar; Bhari, Neetu; Subhadarshani, Sweta; Taneja, Neha; Deepak, Rakesh Kumar

    2016-01-01

    A 70-year-old woman presented with generalized reticulate pigmentation, scarring alopecia, and few discrete, violaceous plaques over the trunk and forearm. Dermoscopic evaluation of the reticulate plaque showed reticulate hyperpigmentation with multiple telangiectasias, and skin biopsy showed lichenoid interface dermatitis with marked pigment incontinence. Thus, a final diagnosis of poikiloderma due to lichen planus pigmentosus was considered. PMID:27904206

  1. Reticulate pigmentation associated with scarring alopecia in an elderly woman: An unusual manifestation of lichen planus pigmentosus

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    Vinod Kumar Sharma

    2016-01-01

    Full Text Available A 70-year-old woman presented with generalized reticulate pigmentation, scarring alopecia, and few discrete, violaceous plaques over the trunk and forearm. Dermoscopic evaluation of the reticulate plaque showed reticulate hyperpigmentation with multiple telangiectasias, and skin biopsy showed lichenoid interface dermatitis with marked pigment incontinence. Thus, a final diagnosis of poikiloderma due to lichen planus pigmentosus was considered.

  2. Lichen Planus Induced by Pegylated Interferon Alfa-2a Therapy in a Patient Monitored for Delta Hepatitis

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    Safak Kaya

    2015-01-01

    Full Text Available Interferons are used for treatment of chronic hepatitis B. They can induce or exacerbate some skin disorders, such as lichen planus. In this study, as we know, we presented the first case developing lichen planus while receiving interferon treatment due to delta hepatitis. A 31-year-old male patient presented to our outpatient clinic with HBsAg positivity. With his analyses, HBV DNA was negative, anti-delta total was positive, ALT was 72 U/L (upper limit 41 U/L, and platelet was 119 000/mm3. He was therefore started on subcutaneous pegylated interferon alfa-2a therapy at 180 mcg/week for delta hepatitis. At month 4 of therapy, the patient developed diffuse eroded lace-like lesions in oral mucosa, white plaques on lips, and itchy papular lesions in the hands and feet. Lichen planus was considered by the dermatology clinic and topical treatment (mometasone furoate was given. The lesions persisted at month 5 of therapy and biopsy samples were obtained from oral mucosal lesions and interferon dose was reduced to 135 mcg/week. Biopsy demonstrated nonkeratinized stratified squamous epithelium; epithelial acanthosis, spongiosis, and apoptotic bodies were observed in the epidermis and therefore lichen planus was considered. At month 6 of therapy, lesions did not improve and even progressed and interferon treatment was therefore discontinued.

  3. Type and Portions of Peripheral Blood T Lymphocytes in Oral Lichen Planus

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    Kia

    2013-06-01

    Full Text Available Background Lichen planus is a disease with unknown etiology that affects the skin and the mucous membranes. Immune dysregulation in the pathogenesis of oral lichen planus (OLP is well-known phenomenon. Objectives In this study, we compared the levels of the peripheral blood T lymphocytes between patients with OLP and control group. Patients and Methods In this study, 32 and 16 patients respectively with and without OLP were recruited. Five milliliters of the participants' peripheral venous blood was drew in an EDTA-containing test tube and the levels of CD3+, CD4+, and CD8+ cells, CD4+/CD8+ and CD4+/CD3+ ratio were measured by means of two-color flow cytometry. The data were analyzed in SPPS v.19 by employing Mann-Whitney U test. Results There were no significant difference among the levels of CD3+, CD4+, and CD8+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes between patients and control group; however, there was a significant difference between male and female patients with respect to the levels of CD3+ and CD4+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes. Conclusions Our results confirm that only local immune mechanism known as skin-associated lymphoid tissue, not a systemic immunologic disorder, was involved in the OLP.

  4. Evaluation of Serum Nitric Oxide level in Patients with Oral Lichen Planus

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    Mehdipour M.

    2014-06-01

    Full Text Available Statement of Problem: Oral lichen planus (OLP is a chronic inflammatory oral mucosal disease with indefinite etiology. In recent researches, free radicals have been deliberated as the possible etiology of inflammatory and autoimmune diseases. Purpose: This study aimed to evaluate the stress oxidative status with the nitric oxide (NO index in a sample of Iranian population. Materials and Method: In this descriptive-comparative study; serum NO level was assessed in 20 OLP patients as the case group and 20 healthy individuals as the control group. Collected data were analyzed by adopting two Sample t-test; using SPSS 16 software. Statistical significance level was set at p < 0.05. Results: The mean serum NO levels in OLP patients and healthy controls were 17.1±3.4 ng/ml and 14.5±2.7 ng/ml respectively; which revealed a significant statistic-al difference (p= 0.009. Conclusions: The results of the current study with its limitation may support the premise that higher serum levels of NO in patients with OLP might activate the process of lymphocytes and cellular immunity system; hence, possibly endorsing the effect of serum NO in pathogenesis of lichen planus.

  5. Langerhans cells in lichen planus and lichenoid mucositis an immunohistochemical study

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    M Devi

    2014-01-01

    Full Text Available Aim: The aim of this study is to identify and evaluate Langerhans cell (LC in lichen planus (LP, lichenoid mucositis (LM and normal mucosa (NM using CD1a monoclonal antibody immunohistochemically. Materials and Methods: A total of 15 cases of oral lichen planus and 15 cases of LM were selected based on clinical examination and confirmed by histopathological analysis. The biopsies from the 10 patients were taken from normal buccal mucosa as control. Paraffin blocks of tissue were made, which are used for routine hematoxylin and eosin staining and immunohistochemical staining using biotin streptavidin methods (CD1a monoclonal antibody. Analysis of CD1a expression was performed by evaluating the labeling index (LI for each slide. Results: The mean CD1a LI for LP was significantly higher than that of LM and NM in the basal and supra basal layer. The mean CD1a positive cells in the connective tissues for LP were higher than that of LM and NM. Conclusion: This study clearly demonstrates a statistically significant increase in number of LC in LP than in LM, indicating the possible different immunopathogenic mechanisms.

  6. Esophageal lichen planus: a case report and review of the literature.

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    Nielsen, Jennifer A; Law, Robert M; Fiman, Keith H; Roberts, Cory A

    2013-01-01

    Esophageal involvement by lichen planus (ELP), previously thought to be quite rare, is a disease much more common in women and frequently the initial manifestation of mucocutaneous lichen planus (LP). Considering that the symptoms of ELP do not present in a predictable manner, ELP is perhaps more under-recognized than rare. To date, four cases of squamous cell carcinoma in association with ELP have been reported, suggesting that timely and accurate diagnosis of ELP is of importance for appropriate follow-up. In this case report, a 69-year-old female presented with dysphagia and odynophagia. She reported a history of oral LP but had no active oral or skin lesions. Endoscopic examination revealed severe strictures and web-like areas in the esophagus. Histologic examination demonstrated extensive denudation of the squamous epithelium, scattered intraepithelial lymphocytes, rare eosinophils and dyskeratotic cells. Direct immunofluorescence showed rare cytoid bodies and was used to exclude other primary immunobullous disorders. By using clinical, endoscopic, and histologic data, a broad list of differential diagnoses can be narrowed, and the accurate diagnosis of ELP can be made, which is essential for proper treatment and subsequent follow-up.

  7. Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease?

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    Feller, Liviu; Khammissa, Razia A G; Lemmer, Johan

    2017-02-10

    Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunoflorescent microscopy are essential for definitive diagnosis. The defining immunopathogenic mechanism is the binding of IgG to the nuclear protein deltaNp63alpha of keratinocytes in the basal and parabasal cell layers of the oral stratified epithelium. DeltaNp63alpha functions as a regulator of epithelial stem cell activity and as an anti-apoptotic agent, and regulates the expression of cell-to-cell and cell-to-basement membrane adhesion molecules. The autoimmune IgG-deltaNp63alpha interaction is thought to result in damage to the structural attachment of keratinocytes to one another and to the epithelial basement membrane zone, and in dysregulation of the cell cycle and apoptosis of basal keratinocytes with the development of erosions or ulcers. The aims of treatment are to suppress the pathogenic immuno-inflammatory responses, to prevent local infection and to promote healing. The purpose of this article is to provide a succinct review of the diagnostic, clinical and aetiopathogenic features of, and treatment guidelines for chronic ulcerative stomatitis, and to argue that this disease should be regarded as a variant of oral lichen planus, rather than as a distinct entity. This article is protected by copyright. All rights reserved.

  8. Expression of COX-2 and bcl-2 in oral lichen planus lesions and lichenoid reactions

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    Arreaza, Alven J; Rivera, Helen; Correnti, María

    2014-01-01

    Oral lichen planus and lichenoid reactions are autoimmune type inflammatory conditions of the oral mucosa with similar clinical and histological characteristics. Recent data suggest that oral lichenoid reactions (OLR) present a greater percentage of malignant transformation than oral lichen planus (OLP). Objective To compare the expression of bcl-2 and COX-2 in OLP and OLR. Methods The study population consisted of 65 cases; 34 cases diagnosed as OLR and 31 as OLP. A retrospective study was done, and bcl-2 and COX-2 expression was semiquantitatively analysed. Results Fifty-three per cent (18/34) of the ORL samples tested positive for COX-2, whereas in the OLP group, 81% of the samples (25/31) immunostained positive for COX-2. The Fisher’s exact test for the expression of COX-2 revealed that there are significant differences between the two groups, P = 0.035. With respect to the expression of the bcl-2 protein, 76% (26/34) of the samples were positive in OLR, while 97% (30/31) were positive in the group with OLP. The Fisher’s exact test for the expression of bcl-2 revealed that there are significant statistical differences between the two groups, P = 0.028. Conclusions The expression of bcl-2 and COX-2 was more commonly expressed in OLP when compared with OLR. PMID:24834112

  9. Oral lichen planus: A retrospective study of 633 patients from Bucharest, Romania

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    Parlatescu, Ioanina; Gheorghe, Carmen; Tovaru, Mihaela; Costache, Mariana; Sardella, Andrea

    2013-01-01

    Objective: In this retrospective study, patients’ medical records were reviewed to investigate the profiles of 633 OLP cases in a group of Romania. Material and Methods: In this retrospective study, the following clinical data were obtained from the medical charts of patients: gender, age, clinical presentation of OLP, site affected, presence of symptoms, extraoral manifestations of lichen planus, presence of systemic diseases, and history of medications. Results: Most (78.67%) OLP patients were female and the mean age at presentation was 52 years. The white type of the disease (reticular/papular/plaque lesions) was the main form encountered in this sample (48.97%). Among patients with available hepatitis C virus test results, 9.6% were serum-positive. OLP was associated with gallbladder disease (i.e. cholecystitis, cholelithiasis) in 19% of patients. Six patients (0.95%) developed squamous cell carcinoma at a site with confirmed OLP lesions. Conclusions: To the best of our knowledge, no similar study has been conducted in a Romanian population. The present investigation revealed the predominance of OLP among middle-aged white women and the prevalence of bilateral involvement of the buccal mucosa with reticular white lesions. Anti-HCV circulating antibodies were more common in patients with OLP than in the general population and, notably, OLP was associated with gallbladder disease (cholecystitis, cholelithiasis) in 19% of patients. Key words:Oral lichen planus, oral mucosal diseases, retrospective study. PMID:23229244

  10. The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study.

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    Garcia-Pola, M-J; Llorente-Pendás, S; González-Garcia, M; García-Martín, J-M

    2016-05-01

    Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus. The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years. The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56.4 years old. None of the patients smoked during the study. As bilateral reticular was clinically diagnostic criterion, the second most frequent clinical form was the plaque form (n=10; 71.4%), followed by the atrophic (n=6; 42.8%), and erosive forms (n=4; 28.5%). Clinically it spread towards attached gingival mucosa and the hard palate. In the histopathologic study, there were a predominance of hyperkeratosis and verrucous epithelial hyperplasia. Three of the cases progressed to a squamous cell carcinoma, and one patient developed two verrucous carcinoma. Further research is needed to demonstrate if proliferative multifocal oral lichen planus and proliferative multifocal oral leukoplakia are the same disorder but have different behaviour of malignancy for reasons of origin.

  11. Interferon-gamma and interleukin-10 levels in serum and saliva are related to different types of oral lichen planus

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    Zhu Jian-hua; Liu Na; Zhao Chang-rong; Liu Ji-guang

    2015-01-01

    Abstract BACKGROUND: Many cytokines can be detected in saliva and serum, and have more clinical significance in the diagnosis, prognosis and treatment of oral mucosa disease. OBJECTIVE: To compare the interferon-γ and interleukin-10 levels in serum and saliva of patients with different types of oral lichen planus and to explore the feasibility of saliva samples as a substitute of blood samples to study the interferon-γ and interleukin-10 levels in serum and saliva. METHODS:Totaly 45 patients with oral lichen planus admitted at the Department of Periodontology, the Stomatological Hospital of Jiamusi University from January to July 2014 were enroled, including 15 cases of erosion type (erosion group), 15 cases of congestive erythema (congestive erythema group) and 15 cases of reticulate type (reticulate group). Another 15 healthy controls admitted for physical examination at the Department of Physical Examination, the Stomatological Hospital of Jiamusi University were enroled as controls. ELISA method was used to detect the interferon-γ and interleukin-10 levels in serum and saliva in the four groups. RESULTS AND CONCLUSION: Compared with the control group, the interferon-γ levels in serum and saliva were lower in the other three groups (P < 0.01), while there were significant differences in the interferon-γ level among the patients with different types of oral lichen planus (P < 0.01). The interleukin-10 levels in serum and saliva were significantly higher in the erosion group and congestive erythema group than those in the control group (P < 0.01 orP < 0.05) and reticulate groupP < 0.01 orP < 0.05). Experimental findings suggest that the levels of interferon-γ and interleukin-10 in serum and saliva are highly correlated in patients with different types of oral lichen planus, and saliva samples can be instead of blood samples to detect the levels of interferon-γ and interleukin-10 in patients with oral lichen planus.

  12. The results of the analysis of lichen planus episodes in the Krasnodar region for 2012-2015years and its clinical features

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    Tlish M.M.

    2016-09-01

    Full Text Available Aim: to study the features of lichen planus in the Krasnodar region. Materials and methods. Total 68 clinical cases have been analyzed. The patients were subdivided into age groups in accordance with physiological age gradation. The Classification of lichen planus proposed by the Federal clinical guidelines for the management of patients with lichen planus (Moscow, 2015 was used. The diagnosis in each case was confirmed by histological examination of biopsy specimens of the skin. The data on the prevalence of lichen planus was obtained from the annual reports of the Clinical dermatovenerology dispensary of Krasnodar city from year 2012 to 2015. Results. Women were found to suffer

  13. Loss of Ab-nerve endings associated with the Merkel cell-neurite complex in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis

    Institute of Scientific and Technical Information of China (English)

    Daniela Caldero n Carrio n; Yu ksel Korkmaz; Britta Cho; Marion Kopp; Wilhelm Bloch; Klaus Addicks; Wilhelm Niedermeier

    2016-01-01

    The Merkel cell-neurite complex initiates the perception of touch and mediates Ab slowly adapting type I responses. Lichen planus is a chronic inflammatory autoimmune disease with T-cell-mediated inflammation, whereas hyperkeratosis is characterized with or without epithelial dysplasia in the oral mucosa. To determine the effects of lichen planus and hyperkeratosis on the Merkel cell-neurite complex, healthy oral mucosal epithelium and lesional oral mucosal epithelium of lichen planus and hyperkeratosis patients were stained by immunohistochemistry (the avidin-biotin-peroxidase complex and double immunofluorescence methods) using pan cytokeratin, 20 (K20, a Merkel cell marker), and neurofilament 200 (NF200, a myelinated Ab- and Ad-nerve fibre marker) antibodies. NF200-immunoreactive (ir) nerve fibres in healthy tissues and in the lesional oralmucosa epitheliumof lichen planus and hyperkeratosis were counted and statistically analysed. In the healthy oral mucosa, K20-positive Merkel cells with and without close association to the intraepithelial NF200-ir nerve fibres were detected. In the lesional oral mucosa of lichen planus and hyperkeratosis patients, extremely rare NF200-ir nerve fibres were detected only in the lamina propria. Compared with healthy tissues, lichen planus and hyperkeratosis tissues had significantly decreased numbers of NF200-ir nerve fibres in the oral mucosal epithelium. Lichen planus and hyperkeratosis were associated with the absence of Ab-nerve endings in the oral mucosal epithelium. Thus, we conclude that mechanosensation mediated by the Merkel cell-neurite complex in the oral mucosal epithelium is impaired in lichen planus and hyperkeratosis.

  14. Loss of Aβ-nerve endings associated with the Merkel cell-neurite complex in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis.

    Science.gov (United States)

    Carrión, Daniela Calderón; Korkmaz, Yüksel; Cho, Britta; Kopp, Marion; Bloch, Wilhelm; Addicks, Klaus; Niedermeier, Wilhelm

    2016-03-30

    The Merkel cell-neurite complex initiates the perception of touch and mediates Aβ slowly adapting type I responses. Lichen planus is a chronic inflammatory autoimmune disease with T-cell-mediated inflammation, whereas hyperkeratosis is characterized with or without epithelial dysplasia in the oral mucosa. To determine the effects of lichen planus and hyperkeratosis on the Merkel cell-neurite complex, healthy oral mucosal epithelium and lesional oral mucosal epithelium of lichen planus and hyperkeratosis patients were stained by immunohistochemistry (the avidin-biotin-peroxidase complex and double immunofluorescence methods) using pan cytokeratin, cytokeratin 20 (K20, a Merkel cell marker), and neurofilament 200 (NF200, a myelinated Aβ- and Aδ-nerve fibre marker) antibodies. NF200-immunoreactive (ir) nerve fibres in healthy tissues and in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis were counted and statistically analysed. In the healthy oral mucosa, K20-positive Merkel cells with and without close association to the intraepithelial NF200-ir nerve fibres were detected. In the lesional oral mucosa of lichen planus and hyperkeratosis patients, extremely rare NF200-ir nerve fibres were detected only in the lamina propria. Compared with healthy tissues, lichen planus and hyperkeratosis tissues had significantly decreased numbers of NF200-ir nerve fibres in the oral mucosal epithelium. Lichen planus and hyperkeratosis were associated with the absence of Aβ-nerve endings in the oral mucosal epithelium. Thus, we conclude that mechanosensation mediated by the Merkel cell-neurite complex in the oral mucosal epithelium is impaired in lichen planus and hyperkeratosis.

  15. Detection of Helicobacter pylori in Oral Lichen Planus and Oral Lichenoid Reaction

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    Irani

    2014-12-01

    Full Text Available Background Oral Lichen Planus (OLP is a chronic inflammatory disease affecting the oral mucosa in 0.5-2% of the world’s population. It is more common in women compared to men and the mean age at the onset of the lesion is the fourth decade. Objectives The purpose of this study was to evaluate the presence of Helicobacter pylori (H. pylori in Oral Lichen Planus and Oral Lichenoid Reaction. Materials and Methods A total of 41 biopsies diagnosed as Oral Lichen Planus and Oral Lichenoid Reaction and 15 samples as the control group were selected from the archives of Pathology Department of Loghman Hakim Hospital, Tehran, Iran from 2002 to 2009. All the paraffin blocks were cut for hematoxylin and eosin (H and E staining to confirm the diagnoses and the samples were then prepared for immunohistochemistry (IHC staining. Statistical analysis was performed using SPSS statistical software (version 21.0, the chi-squared test and Fisher’s exact test, and independent-samples t test. Statistical significance between the groups was set at P < 0.05. Results The H. pylori positivity was found in 29.7% and 14.8% of OLP, and OLR samples, respectively. Statistically significant difference was not observed compared to normal tissues (P = 0.661. The chi-squared test show no significant difference between the frequency of H. pylori positivity and the lesion type, gender, and site. Although H. pylori positivity was found in 59.2%, and 50 % of OLP, and OLR samples, respectively, statistically significant difference was not observed compared to normal tissues (P = 0.838. In addition, the chi-squared test show no significant difference between the site of the lesion and H. pylori positivity. H. pylori positivity was mostly found on the buccal mucosa (64.3%, however, H. pylori negativity was mostly found on the tongue (60 % (P = 0.309. Additionally, the chi-squared test show no significant difference between the frequency of H. pylori positivity, and the gender (P = 0

  16. Efficacy of topical chamomile management vs. placebo in patients with oral lichen planus: a randomized double-blind study.

    Science.gov (United States)

    Lopez Jornet, P; Aznar-Cayuela, C

    2016-10-01

    The purpose of this study was to compare the clinical therapeutic efficacy of topical applications of chamomile vs. a placebo for treating oral lichen planus (OLP). This double-blind study, randomly divided 60 patients with OLP into two groups, 30 treated with 2% Chamaemelum nobile gel (0.5 mL/3 times a day) and 30 treated with a placebo (Trial Registration NCT02421770). A visual analogue scale was used to rate pain, itching and burning sensation, and Thongprasom Index, the Oral Health Impact Profile 14 (OHIP-14) and the Hospital Anxiety-Depression Scale. Patients were evaluated at baseline and after 4 weeks of treatment. Patients treated with chamomile showed significant improvements after 4 weeks for pain (P < 0.001), burning sensation (P < 0.001), itching (P = 0.011), OHIP-14 (P < 0.001) and Thongprasom index (P = 0.001); 92% of patients treated with chamomile showed a partial or total response, while only five subjects (17%) in the placebo group showed any improvement. The topical application of 2% chamomile gel is an effective treatment for OLP. © 2016 European Academy of Dermatology and Venereology.

  17. Tumor-like microenvironment in oral lichen planus: evidence of malignant transformation?

    Science.gov (United States)

    Peng, Qiao; Zhang, Jing; Ye, Xiaojing; Zhou, Gang

    2017-06-01

    Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory autoimmune disease affecting 0.1% to 4% of the world population. The WHO has already recognized it as an oral potentially malignant disorder. However, the reasons for the malignant transformation of OLP are far from being elucidated clearly. The purpose of this review is to clarify how the tumor-like microenvironment in OLP mediates its potentially malignant transformation. Areas covered: We review published articles on the microenvironment characteristics of tumors, the pathogenesis of OLP, and clinical studies of OLP. The main sources of literature derive from MEDLINE/Pubmed and Thomson Reuter's Web of Science. Expert commentary: The tumor-like microenvironment, including hypoxic, inflammatory, immune and acid microenvironment, greatly contributes to carcinogenesis of OLP patients. In order to effectively monitor the malignant transformation of OLP, future studies should focus on long-term follow-up and select important detection biomarkers.

  18. Hypertrophic lichen planus as a presenting feature of human immunodeficiency virus infection

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    Kumari Rashmi

    2009-01-01

    Full Text Available Lichen planus (LP is a chronic papulosquamous dermatosis in which both skin and mucous membranes may be involved. To date, there have been only five reports of human immunodeficiency virus (HIV-positive patients with hypertrophic LP. In the present report, we describe a 37-year-old female who presented with widely distributed, hyperpigmented, pruritic scaly lesions involving the face, trunk, and upper and lower extremities for one month. She also had swelling of both lower legs with low grade fever for past one week. She was diagnosed to be a HIV-positive patient who had severe, widespread hypertrophic LP lesions along with acute eruptive lesions of LP. These LP lesions were a presenting feature of HIV infection in our case.

  19. A Retrospective and Comparative Study of Familial and Non-familial Bullous Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    HUANG Changzheng; YAN Xiaofeng; YANG Lingyun; ZHANG Jing; TIAN Jin; LI Jiawen; WANG Chunsen; TU Yating

    2007-01-01

    In order to compare the clinical characteristics of familial and non-familial bullous lichen planus (BLP), the archival data of 36 BLP patients with positive family history and 21 BLP patients with negative family history diagnosed according to the clinical features and histopathology were collected in our department from 1956 to 2003. The clinical features were analyzed and compared. There were significant differences between familial and non-familial BLP in age of onset, duration of disease and extension of eruption (P<0.01). It was concluded that familial BLP appeared to differ from the non-familial form in its earlier age of onset, longer duration of the disease, more extensive eruption and more tendency to involve nails. Hereditary factors may play a role in the pathogenesis of familial BLP.

  20. Comparison of Periodontal Status in Gingival Oral Lichen Planus Patients and Healthy Subjects

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    Arash Azizi

    2012-01-01

    Full Text Available Background and Objective. Oral lichen planus (OLP is a common chronic mucocutaneous disease. OLP can occur in different oral sites such as gingiva. The purpose of study was to evaluate the periodontal status of OLP patients with desquamative gingivitis (DG and compare it with that of healthy control. Methods. This study was case-control. 32 patients with gingival OLP as a case group and 32 healthy subjects as a control group were selected. The periodontal status of all subjects including plaque index (PI, bleeding on probing (BOP, and clinical attachment level (CAL was evaluated in both groups. Finally data were analyzed by t-test. Results. The mean values of periodontal parameters were observed to be higher in case group compared with control group, and this was significant (<0.05. Conclusion. Our results showed that periodontal status is worse in gingival OLP if compared with healthy controls.

  1. MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma

    DEFF Research Database (Denmark)

    Dang, Jun; Bian, Yong-qian; Sun, Jian-yong

    2013-01-01

    Oral lichen planus (OLP) is a common oral mucosal disease, which is generally considered a potentially malignant lesion. To identify efficiently prognostic biomarker, we investigated the microRNA-137 (miR-137) promoter methylation in OLP and compared with the samples from healthy volunteers...... and patients with oral squamous cell carcinoma (OSCC). A total of 20 OLP and 12 patients with OSCC as well as 10 healthy subjects were subjected to miR-137 promoter methylation analysis using methylation-specific PCR (MSP). To address the malignancy prediction potential from miR-137 promoter methylation status...... between miR-137 and p16 methylation levels were statistically significant between healthy controls and patients. Methylation levels of the two promoters were also influenced by age, gender, and lesion duration. Interestingly, aberrant promoter methylation of the p16 and miR-137 genes was only found...

  2. INTERDISCIPLINARY APPROACH IN COMPEX TREATMENT OF ORAL LICHEN RUBER PLANUS /Review and a Case report/

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    Atanaska Dinkova

    2010-07-01

    Full Text Available Lichen planus(LPis a common chronic muco­cuta­neous disease of unknown etiology. Usually, it presents with lesions on the flexor surfaces of the upper extremities, genitalia and mucous membranes. Oral lesions can be the initial as well as the only manifestations of this condition. Patients with LP can present first to the general dental practitioner so sufficient knowledge on this condition is important for the proper diagnosis, treatment and prevention of further complications. The clinical management of LRP requires liaison between dental and medical specialists.This article provides a review of the current literature on LP and a case report of a 55 years old female suffering with this condition. A multidisciplinary approach in the diagnosis and management of this case is described.

  3. Diagnostics of oral lichen planus based on analysis of volatile organic compounds in saliva

    Science.gov (United States)

    Kistenev, Yury; Borisov, Alexey; Shapovalov, Alexander; Baydik, Olga; Titarenko, Maria

    2017-03-01

    The ability of diagnostics of oral lichen planus (OLP) based on spectral analysis of saliva using the THz spectroscopy is presented. The study included 8 patients with clinically proven OLP. The comparison group consisted of 8 healthy volunteers. Absorption spectra of the saliva was measured using time-domain spectrometer T-spec (EXPLA) in the range 0.2-3THz and have been considered as the feature vectors of the state. The spatial distribution of the objects under study in the feature space was analyzed using principle component analysis. The groups under study were shown to separate in full. Thus, the saliva analysis by the THz spectroscopy technique can be potentially used as a method of noninvasive diagnostics of the OLP.

  4. Evaluation of salivary cortisol and psychological factors in patients with oral lichen planus

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    Shah Bina

    2009-01-01

    Full Text Available Background and Objectives: Lichen planus is a relatively common chronic inflammatory disease of oral mucosa and skin. Cortisol, also called as "stress hormone", has been used as an indicator in various stress evaluation studies. Salivary cortisol measurement is an indicator of free cortisol or biologically active cortisol in human serum and provides noninvasive and easy technique. Recent studies have been conflicting, and hence, in the present study, evaluation of salivary cortisol levels and psychosocial factors in oral lichen planus (OLP patients was done. Materials and Methods: A total of 30 patients with clinically and histopathologically proven cases of OLP, along with the age and sex-matched healthy controls were included in the study. Samples of stimulated saliva were collected, centrifuged and analyzed for the level of cortisol with cortisol enzyme linked immunosorbent assay. Psychosocial factors of study and control groups were measured by depression anxiety and stress scale. Student′s t-test was used to compare the psychological factors and salivary cortisol levels between patients with the OLP and the control group. Results: Irrespective of sex, significantly higher depression (83.4 ± 15.4%, anxiety (80.5 ± 11.3%, and stress (94.2 ± 6.2% scores were observed in OLP patients compared to controls. Increased cortisol levels were observed among 17 (56.6% OLP patients in the study group. A positive correlation was found between psychological factors and salivary cortisol levels in the OLP patients. The values of Pearson′s correlation coefficient "r", between depression, anxiety, and stress with salivary cortisol was: +0.42,S; +0.27,NS; and +0.65,HS, respectively among the study group.

  5. Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study

    Science.gov (United States)

    Mozaffari, Hamid Reza; Sharifi, Roohollah; Sadeghi, Masoud

    2016-01-01

    Background: Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study. Methods: In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database), Cochrane and Embase databases. Strategy search was the Medical Subject Heading (MeSH) term oral lichen planus or oral mucosa combined with diabetes in PubMed and this search in other databases. Heterogeneity between estimates was evaluated by the Q and I2 statistic. Also, publication bias was assessed through funnel plot analysis with the Kendall’s and Egger’s tests. Results: From 831 studies were identified with different search strategies, 11 studies met the criteria to be included in meta-analysis (11 case-control studies). The overall prevalence of OLP in 11 studies with 4937 DM patients and 3698 control subjectswas 1.5% and 0.75%, respectively. In this meta-analysis, the OR in prevalence of OLP in DM patients compared with control subjects was 1.584 (95%CI1.013-2.477; P=0.044) with a low level of heterogeneity (I2 = 0%) that the result showed the prevalence of OLP in DM patients is significantly more than control subjects. Conclusions: This meta-analysis study showed an association between OLP with DM, whereas this association was no significant in previous studies, it was probably because different selecting of age, sex, type of DM, medications and criteria. Totally, the meta-analysis showed the risk of OLP in DM was higher compared with control subjects. PMID:28077900

  6. Role of serum interleukin-6 in deciding therapy for multidrug resistant oral lichen planus

    Science.gov (United States)

    Marwah, Akanksha; Kaushik, Smita; Garg, Vijay K.; Gupta, Sunita

    2015-01-01

    Background Oral lichen planus (OLP) is a T cell mediated immune response. T cells locally present in the involved tissues release cytokines like interleukin-6 (IL-6), which contributes to pathogenesis of OLP. Also IL-6 has been associated with multidrug resistance protein (MRP) expression by keratinocytes. Correspondingly, upregulation of MRP was found in OLP. We conducted this study to evaluate the effects of various drugs on serum IL-6 in OLP; and correlation of these effects with the nature of clinical response and resistance pattern seen in OLP lesions with various therapeutic modalities. Thus we evaluated the role of serum IL-6 in deciding therapy for multidrug resistant OLP. Material and Methods Serum IL-6 was evaluated in 42 erosive OLP (EOLP) patients and 10 normal mucosa and 10 oral squamous cell carcinoma cases using ELISA technique. OLP patients were randomly divided into 3 groups of 14 patients each and were subjected to Pimecrolimus local application, oral Mycophenolate Mofetil (MMF) and Methotrexate (MTX) alongwith Pimecrolimus local application. IL-6 levels were evaluated before and after treatment. Results Serum IL-6 levels were raised above 3pg/ml in 26.19% erosive OLP (EOLP) cases (mean- 3.72±8.14). EOLP (5%) cases with IL-6 levels above 5pg/ml were resistant in MTX group. However significant decrease in serum IL-6 corresponding with the clinical resolution was seen in MMF group. Conclusions Significantly raised IL-6 levels in EOLP reflect the chronic inflammatory nature of the disease. As serum IL-6 levels significantly decreased in MMF group, correspondingly no resistance to treatment was noted. However with MTX there was no significant decrease in IL-6 and resistance to treatment was noted in some, especially plaque type lesions. Thus IL-6 can be a possible biomarker in deciding the best possible therapy for treatment resistant OLP. Key words:Lichen planus, biological markers, cytokines, enzyme-linked immunosorbent assay, immunosuppressive

  7. A Comparative Evaluation of Low-Level Laser and Topical Steroid Therapies for the Treatment of Erosive-Atrophic Lichen Planus

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    Hanaa M. Elshenawy

    2015-08-01

    Full Text Available BACKGROUND: Oral lichen planus (OLP is a chronic inflammatory disease that causes bilateral white striations, papules, or plaques on the buccal mucosa, tongue, and gingivae. Erythema, erosions, and blisters may or may not be present. Several empirical therapies have been used in the treatment of (OLP. OBJECTIVE: To evaluate the effect of low level laser therapy (LLLT versus topical steroids for the treatment of erosive-atrophic lichen planus. SUBJECTS AND METHODS: Twenty-four patients with erosive-atrophic (OLP were categorized into two groups. In the first group patients were treated with 970nm diode laser irradiation, while, in the second group patients used topical corticosteroids (0.1% triamcinolone acetonide orabase. The gender, medical history and pain score were recorded. The pain score was measured before and after treatment by visual analogue scale (VAS. RESULTS: Steroid-treated group (0.1% triamcinolone acetonide orabase show reduced pain score than laser group. CONCLUSION: Topical steroids are more effective than LLLT. LLLT may be used as an alternative treatment for symptomatic OLP when steroids are contraindicated.

  8. The significance of oral and systemic factors in Australian and Croatian patients with oral lichen planus.

    Science.gov (United States)

    Vučićević Boras, Vanja; Savage, Neil William; Brailo, Vlaho; Škrinjar, Ivana; Valter, Kruna; Alajbeg, Iva; Dulčić, Nikša; Vidović Juras, Danica

    2014-01-01

    Oral lichen planus (OLP) is an immunologically T cell-mediated disease caused by an unknown stimulus. Despite intensive investigation its pathogenesis still remains unknown. A few possible associations between OLP and certain diseases such as thyroid and malignant diseases as well as specific medication intake have been proposed in the literature with inconsistent findings. We aimed to investigate the profile of 163 Australian and 163 Croatian OLP patients with special regard to their systemic diseases, medication intake (with special regard to the drugs that metabolize through Cytochrome P450), OLP type and localization, as well as involvement of other body surfaces with lichen. We did not find any statistical significance with regard to the OLP presence and thyroid and malignant diseases. As expected, the reticular type of OLP was most prevalent, as well as involvement of the both buccal mucosas. There was no significant association with other oral diseases such as labial herpes. Simultaneous involvement of other body surfaces in patients with OLP does not seem to be prevalent. None of the medical conditions which were investigated had significant correlation with OLP neither in Australian nor in Croatian patients with OLP. Furthermore, the use of drugs which metabolize through Cytochrome P450 (CYP450) was not significantly correlated with OLP in either studied population. Therefore, we conclude that patients with OLP are not to be routinely screened for any systemic conditions.

  9. The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta-analysis.

    Science.gov (United States)

    Ali, S; Wahbi, W

    2017-10-01

    The main objective of oral lichen planus management is to control symptomatic outbreaks via eliminating lesions and alleviating symptoms. Corticosteroids, calcineurin inhibitors, and most of the available modalities are associated with adverse effects, which may limit their use. The aim of this review was to assess the effect of aloe vera on pain alleviation and/or clinical improvement in patients with symptomatic oral lichen planus. MEDLINE-PubMed; CENTRAL, and LILACS were searched in May 2016 to identify all clinical trials evaluating aloe vera vs placebo or corticosteroids for treatment of oral lichen planus. The included studies were five clinical trials and two case reports. From the included studies, there is weak evidence that aloe vera is more efficient than placebo and has comparable effect to triamcinolone acetonide. The meta-analyses show heterogeneity and reveals that aloe vera is inferior to the control in general. Although corticosteroids are still the gold standard, aloe vera shows promising results especially with no adverse effects compared with various adverse effects of corticosteroids. We recommend conducting new randomized clinical trials with larger sample size, sufficiently long follow-up period as well as standardized aloe vera formulations and outcome measures. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Epidemiological evidence of the association between lichen planus and two immune-related diseases. Alopecia areata and ulcerative colitis. Gruppo Italiano Studi Epidemiologici in Dermatologia.

    Science.gov (United States)

    1991-05-01

    Between September 1986 and February 1988, a case-control study involving 27 Italian dermatological centers collaborating in the Gruppo Italiano Studi Epidemiologici in Dermatologia was conducted, concerning the relationship between history of several medical conditions and exposures to drugs and the risk of lichen planus. The cases were all consecutive patients with a new diagnosis of lichen planus, and the controls were patients under dermatological care observed under the same conditions. A total of 711 cases and 1395 controls met the admission criteria and were interviewed by trained investigators. Patients with histories of alopecia areata were found to be at risk for lichen planus (relative risk = 2.7; 95% confidence interval, 1.1 to 6.5). Five patients (0.7%) in the group with lichen planus had a history of ulcerative colitis, while none of the controls had this disease. The risk of lichen planus was also increased in patients with a history of chronic active hepatitis, but this increase was not statistically significant (relative risk = 4.7; 95% confidence interval, 0.7 to 29.4).

  11. Determination of cytokeratins 1, 13 and 14 in oral lichen planus

    Science.gov (United States)

    Innocenti, Alicia C.; Cippitelli, María J.; Salomón, Susana; Vargas-Roig, Laura M.

    2014-01-01

    Introduccion: Cytokeratins (CK) are molecules of the cytoskeleton that contribute to the cellular differenciation. We studied the expression of CK1, CK13 and CK14 in thirty-three patients with OLP. The biopsied lesions were located in the dorsal surface of the tongue, the palatal keratinized mucosa and the nonkeratinized buccal mucosa. Objectives: This study aimed to determine the expression of CK1, CK13 and CK14 in oral lichen planus (OLP) and its relations with: clinical patterns, prognosis, drugs and tobacco intake and histopathological features. Study Design: Immunohistochemical analysis, retrospective, descriptive, observational and no randomized study. Results: No significant difference was observed in the expression of CK1 in patients with or without drug treatment. No association was found with the amount of drugs intake or smoking nor with the histopathological features examined. Samples immunostained with CK13 were all positive in the suprabasal layers, and 13 of them in the basal layer. In these last ones, statistical analysis showed significance in the grade of vacuolization of the basal layer (p=0.023) and in the degree of exocytosis (p=0.0025), this, making the degree of affection higher for both parameters. Thirty-two tissue sections were immunostained with CK14. CK14 was expressed in the basal layer in 97% of samples and in the suprabasal layer in 94% of samples. Conclusions: The three CK were altered in OLP. CK1 does not have a direct connection with the presence of orthokeratosis. The finding of the CK13 in the basal layer is related to the agression of the lymphocytic infiltration in the epithelium, due to the basal stratum vacuolization and the increase in lymphocytic exocitosis. The presence of CK14 in the suprabasal stratums is not a parameter to predict malignancy. The CK in OLP do not follow the normal pattern of keratinized or non-keratinized mucosa. Key words:Basal cell vacuolization, CK1, CK13, CK14, cytokeratin, lymphocytic exocytosis

  12. Therapy ideas for oral lichen planus of different variants%口腔扁平苔藓的分型治疗思路

    Institute of Scientific and Technical Information of China (English)

    周红梅; 刘传霞

    2012-01-01

    The variants of oral lichen planus are complex A single treatment program is difficult to relieve all types of oral lichen planus effectively. In this paper, oral lichen planus will be classified into several subtypes in details, and various therapy ideas and approaches will be introduced .%口腔扁平苔藓病损类型复杂多样,仅采用单一的治疗方案难以获得良好的控制效果,本文将对其进行分类细化至各个亚型,并对各型的治疗思路进行较详细地梳理和解析.

  13. Expressions of Ki-67 and vascular endothelial growth factor in lichen planus%扁平苔藓中Ki-67和VEGF的表达

    Institute of Scientific and Technical Information of China (English)

    王娟; 白莉; 鲍海平; 郑爱义; 武晓华; 赵一锦; 邓起; 米希婷

    2012-01-01

    Objective To investigate the expressions of Ki-67 and vascular endothelial growth factor (VEGF) in lichen planus and explore their effects on the pathogenesis of lichen planus. Methods The expressions of Ki-67 and VEGF in 20 lichen planus and 20 normal skin specimens were detected by immunohistochemical method. Results The expressions Ki-67 and VEGF were significantly higher in lichen planus than those in normal skins (P < 0.01). There was a positive correlation between the expression of Ki-67 and VEGF in lichen planus (r = 0.74, P < 0.01). Conclusions The up-regulated expressions of Ki-67 and VEGF may play an important role in the development of lichen planus.%目的:研究扁平苔藓皮损中Ki-67和血管内皮生长因子(VEGF)的表达情况,探讨它们在扁平苔藓发病中的作用.方法:采用免疫组化法检测20例扁平苔藓皮损中Ki-67和VEGF的表达情况,20例正常皮肤作为对照.结果:扁平苔藓组中Ki-67和VEGF的表达水平明显高于对照组,差别具有统计学意义(P < 0.01);扁平苔藓皮损中Ki-67和VEGF的表达呈正相关(r = 0.74,P < 0.01).结论:Ki-67、VEGF的异常高表达可能参与了扁平苔藓的发病.

  14. Prevalence of oral leukoplakia and lichen planus in 1167 Iranian textile workers.

    Science.gov (United States)

    Jahanbani, J

    2003-11-01

    To evaluate the prevalence of oral precancerous lesions in textile workers. A cross-sectional study was undertaken to assess a total of 1167 textile factory workers randomly selected from a total of 6947. An overall 97 women and 1070 men aged 18-69 years (mean=31.8 years) were studied. Regular smoking during the past 6 months was considered as the smoker group. Leukoplakia lesions were classified in accordance to Axell criteria [Axell T, Pindborg JJ, Smith CJ and Van-der-waal I (1996). J Oral Pathol Med 25: 49]. The results showed that 115 workers (9.9%) had red and white lesions. Among these 43 positive detections (3.7%) had leukoplakia and six cases (0.5%) had lichen planus. The smoking habits of the workers were limited to cigarette smoking. There was a statistically significant positive correlation between tobacco smoking and oral leukoplakia (P<0.001). There was a statistically significant positive correlation between tobacco smoking and leukoplakia in this relatively young cohort with generally mild tobacco use. The prevalence of leukoplakia had an inverse relationship with the level of education.

  15. Salivary concentration of the antimicrobial peptide LL-37 in patients with oral lichen planus

    Directory of Open Access Journals (Sweden)

    Sotiria Davidopoulou

    2014-12-01

    Full Text Available Background: The antimicrobial peptide LL-37 is a significant molecule of innate immunity and recent studies indicate that it plays an important role in maintaining oral health. Yet limited knowledge exists on its role in oral diseases and oral lichen planus (OLP in particular. Objective: The study aimed to examine: 1 the salivary concentration of LL-37 in patients with OLP and healthy subjects, 2 the relation between the type (reticular or erosive and size of OLP lesions and LL-37 concentration, and 3 the effect of the therapeutic modalities on LL-37 levels. Design: The salivary peptide concentration in samples from 20 patients and 30 healthy subjects at the same age range was determined by ELISA. Results: Despite the wide variation in peptide concentration found in both groups, the healthy subjects exhibited significantly lower levels than patients. Patients with the erosive form had significantly higher peptide concentrations than patients with the reticular form. Systemic treatment with corticosteroids resulted in a significant decrease of the salivary peptide concentration, while other treatment modalities, such as administration of vitamins A and E or local application of corticosteroids had no effect. Improved clinical appearance of the lesions was followed by a decrease in the salivary LL-37 level. Conclusions: Salivary concentration of LL-37 correlates to the manifestation of mucosa lesions in OLP patients, the highest levels being observed in the most severe cases. This increase in peptide levels may protect against lesion infection and promote a quick wound healing.

  16. Biodistribution of protoporphyrin IX in female genital erosive lichen planus after topical application of hexaminolevulinate.

    Science.gov (United States)

    Helgesen, Anne Lise Ording; Gjersvik, Petter; Peng, Qian; Vasovic, Vlada; Pripp, Are Hugo; Jebsen, Peter; Tanbo, Tom; Warloe, Trond

    2014-06-01

    Genital erosive lichen planus (GELP) is a chronic inflammatory disease, in women characterized by painful vulvar and vaginal erosions. To prepare for a clinical trial on photodynamic treatment (PDT), we applied hexyl 5-aminolevulinate hydrochloride (HAL) in clinically normal and affected mucosa in 12 women with GELP using two different doses (6.25 or 50mg/ml). Biopsies were taken after 30 min and 3h. The biodistribution of HAL, measured as photoactive protoporphyrin IX (PpIX), was studied using non-invasive superficial fluorescence measurements and microscopic fluorescence photometry. More PpIX was detected after application of 12.5mg HAL than after 100mg, with large inter-individual variations. PpIX levels after 3h were overall higher than after 30 min. PpIX fluorescence was not detected in skin distant to the genital area. In conclusion, 6.25mg/ml HAL applied for 3h seems adequate for HAL absorption and conversion to PpIX in submucosal inflammatory and epithelial cells and can be used in a PDT trial of GELP.

  17. Quantitative comparison of angiogenesis and lymphangiogenesis in cutaneous lichen planus and psoriasis: immunohistochemical assessment.

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    Výbohová, Desanka; Mellová, Yvetta; Adamicová, Katarína; Adamkov, Marián; Hešková, Gabriela

    2015-01-01

    Recent experimental studies revealed that angiogenesis and lymphangiogenesis are closely related to chronic inflammation. The present study aims to evaluate quantitative changes of blood and lymphatic microcirculatory beds in cutaneous lichen planus (CLP) and psoriatic lesions using immunohistochemical analysis with antibodies to CD34, D2-40 and VEGF. Morphometric software was used to determine the area of blood and lymphatic vessels (BVA and LVA) and also the VEGF positive area. Statistical analysis of these parameters confirmed a significant enlargement of both the blood and lymphatic microcirculatory beds in psoriatic and CLP lesions. BVA in CLP lesions was increased by 56% however this augmentation was not as great as in psoriatic lesions where BVA was increased by 123%. Interestingly, LVA in psoriatic and CLP lesions was increased equally by 85%. The strongest VEGF expression was detected in psoriatic lesions, with lower, but still significant, overexpression in CLP lesions. VEGF-C was significantly increased in both psoriatic and CLP lesions in comparable level. Noticeably higher VEGF and VEGF-C expression was observed in the epidermis than in the dermis. Finally, our results indicate that the level of angiogenesis is considerably greater in psoriatic lesions than in CLP lesions, but the level of lymphangiogenesis is equal in both psoriatic and CLP lesions.

  18. Lichen planus complicated with thymoma: Report of three Japanese cases and review of the published work.

    Science.gov (United States)

    Motegi, Sei-Ichiro; Uchiyama, Akihiko; Yamada, Kazuya; Toki, Sayaka; Amano, Hiroo; Ishikawa, Osamu

    2015-11-01

    Thymoma is recognized to be complicated with autoimmune diseases, such as myasthenia gravis, pemphigus vulgaris and bullous pemphigoid. Abnormal regulation of autoreactive lymphocytes may be involved in the pathogenesis of the autoimmune diseases. The association of thymoma and lichen planus (LP) is relatively rare. Among 50 patients with LP, we identified three patients with LP accompanied by thymoma (6%; 3/50) in our department from 2004 to 2014. This is the first report identifying the frequency of thymoma accompanied by LP among patients with LP. We herein report three cases of LP accompanied by thymoma along with clinical and histological features. In addition, we summarize 29 LP patients accompanied by thymoma previously reported in the English-language published works. Regarding the complications, hypogammaglobulinemia accompanied 58.6% (17/29) of patients diagnosed with Good's syndrome. Alopecia was present in 13.8% (4/29) of patients, and myasthenia gravis was present in 17.2% (5/29) of patients with LP and thymoma. Among the 27 patients with thymectomy, only 25.9% (7/27) experienced the improvement of LP, suggesting that thymectomy may not be effective for the lesions of LP. Treatment-resistant LP was reported in 54.2% (13/24) of patients. In all our cases, oral lesions were intractable to treatment with oral predonisone and topical steroids and/or tacrolimus. It is important for dermatologists to recognize the clinical characteristics of the patients with both LP and thymoma.

  19. Investigation of Conjunctival Involvement in Patients with Lichen Planus Without Ocular Symptoms

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    Pinar Ozuguz

    2015-11-01

    Full Text Available Aim: Lichen planus is characterized by violeceous, poligonal, flat-topped and itch papules, either isolated or in groups, commonly located in flexural surfaces, mucosa and scalp. Mucous membranes are frequently affected (30-70%. Mucous membrane lesions can be seen in the absence of skin lesions and in about 15-25% of the cases mucosal lesions are the only sign of the disease. Besides, buccal mucosa and tongue; lesions in anogenital mucosa, urinary bladder, conjunctiva, larynx and occasionally even in esophagus and tympanic membrane of the ear can be seen. We aimed to investigate involvement of conjunctiva in patients with clinical and histopathological diagnosis of LP. Material and Method: 31 patients and 16 healthy controls were enrolled to the study. Conjunctival scrapings taken under eyelid local anesthesia from both patient and controls. The scrapings collected in cytospin, and by using immunohistochemical method, lymphocyte cell counts were done. The data obtained from the patients and the control group compared with the Mann-Whitney U tests and the results were statistically significant. Discussion: Our study supports the disease can affect all the mucosal surfaces by detection of histopathological involvement in patients with LP without clinical symptoms of eye disease.

  20. Can atrophic erosive oral lichen planus promote cardiovascular diseases? A population-based study.

    Science.gov (United States)

    Conrotto, Davide; Barattero, Roberta; Carbone, Mario; Gambino, Alessio; Sciannameo, Veronica; Ricceri, Fulvio; Conrotto, Federico; Broccoletti, Roberto; Arduino, Paolo G

    2017-06-19

    Lichen planus has been recently associated with an increased risk of cardiovascular diseases (CVDs). The oral manifestations can be divided into white hyperkeratotic lesions (WL) and atrophic erosive lesions (RL). The aim of this report was to compare the presence of CVDs between patients affected by WL or RL, to test the hypothesis that RL are associated with an increased incidence of CVDs. Patients were analysed through a complete collection of all the risk factors for CVDs. The primary endpoint was the occurrence of a cardiovascular event -acute coronary syndrome (ACS), any revascularization or stroke/TIA. A multivariable logistic regression model, adjusted for age at diagnosis, body mass index, smoking, alcohol consumption, diabetes, hypertension, CVDs familiarity and periodontitis was performed. A prospective cohort of 307 patients has been evaluated; 185 (60.3%) had WL and 122 RL (39.7%). Twenty-four patients had a CVD. ACS occurred more frequently in RL (adjusted odd ratio 5.83; 95%CI: 1.16-29.39), mainly due to the higher risk of it after the histological diagnosis of OLP (odd ratio 4.23; 95%CI: 0.66-27.23). Patients with RL could possibly have a higher risk of developing ACS. Further analysis on larger cohort are however warranted. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  1. Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study

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    Marinka Mravak-Stipetić

    2014-01-01

    Full Text Available Oral lichen planus (OLP and oral lichenoid lesions (OLL are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Thus, the aim of this study was to determine the correlation of histopathology and clinical OLP and OLL diagnosis and to clarify which histopathologic criteria could best distinguish these two diagnoses. A retrospective study showed that clinically diagnosed 92 OLPs and 14 OLLs have been confirmed histopathologically in 52.2% and 42.9% of cases, respectively. In addition, histopathology showed statistically significant more eosinophils (P<0.0005, plasma cells (P<0.0005, and granulocytes (P<0.05 in OLL than OLP. To establish histopathological diagnosis of OLP and OLL it should be mandatory to define the type of cells in mononuclear infiltrate, which can be associated more accurately with clinical feature and patient history. Therefore, currently accepted diagnostic criteria for OLP and OLL should be modified and validated on a larger number of patients taking into account particular distinguishing histopathological features.

  2. Evaluation of oral epithelial dysplastic features in oral lichen planus: The diagnostic difficulties

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    Bina Kashyap

    2015-01-01

    Full Text Available Background: Lichen planus (LP is chronic, mucocutaneous, autoimmune disease which can affect oral mucosa, skin, scalp, nails, and genital mucosa. The prevalence of oral LP (OLP varies with different geographic distribution. It presents symmetrical and bilateral or multiple lesions with varying clinical types accompanying with burning sensation and sometimes pain. Due to its potentially malignant nature, the evaluation of cell proliferation brings important information regarding diagnosis and prognosis of several types of cancer. Materials and Methods: Sixty-four cases of OLP were retrieved and were histologically assessed under 10× and 40× magnifications for valuation of the dysplastic features. The grading was done by the criteria followed by Odukoya et al. The data obtained were tabulated and subjected for the statistical analysis. Results: Epithelial dysplasias were observed in 60 cases of OLP which Grade I had 9 cases, Grade II 27 and Grade III 24 cases. Four cases of OLP did not show any dysplasia. The interrater reliability was found to be in strong or substantial agreement in assessing few of the dysplastic features. Male:female ratio was 1.2:1 with buccal mucosa being the most common site. Conclusion: Our study showed the importance to establish a correct diagnosis of OLP based on the history, clinical presentations, and histopathology. Furthermore, the long-term follow-up of the patient with OLP is mandatory when dysplasia is encountered on histopathology.

  3. Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

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    Farzam Gorouhi

    2014-01-01

    Full Text Available Lichen planus (LP is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. In this paper, we review the history, epidemiology, and clinical subtypes of LP. We also review the histopathologic aspects of the disease, differential diagnoses, immunopathogenesis, and the clinical and genetic correlations.

  4. The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

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    Mehmet Kamil Mülayim

    2016-12-01

    Full Text Available Objectives: Oral lichen planus (OLP is a chronic inflammatory disorder of unknown etiology that affects the skin and the mucosa, especially the oral mucosa. Several therapeutic agents have been investigated for the treatment of OLP. All agents used in the OLP therapy are palliative. Potent topical steroids are used as the conventional therapy for OLP. Since side-effects or steroid resistance may be encountered, alternative treatments may be necessary. This study aimed to evaluate the efficacy and safety of the topical pimecrolimus in the treatment of OLP. Methods: Seventeen patients with OLP were recruited into this study. Topical pimecrolimus 1% cream was applied twice a day to the affected areas. Patients were followed up for 3-6 months. Photographs of the lesions were taken and analyzed for areas of ulceration, erythema, and reticulation in every clinical examination. Results: We found that topical pimecrolimus 1% cream was an effective treatment for OLP. Two patients could not complete the treatment protocol because of the side effects such as local irritation and nausea. Conclusion: Topical pimecrolimus may be a valuable second treatment choice for patients with steroid-related side-effects or steroid-resistant OLP. However further randomized controlled studies have to be conducted to compare conventional treatment of topical corticosteroid with topical pimecrolimus.

  5. Foxp3 gene expression in oral lichen planus: a clinicopathological study.

    Science.gov (United States)

    Lei, Lei; Zhan, Lihua; Tan, Weixia; Chen, Shaohua; Li, Yangqiu; Reynolds, Mark

    2014-03-01

    CD4+CD25+ Forkhead‑box protein 3 (Foxp3+) regulatory T cells are important in oral lichen planus (OLP). The present study aimed to investigate Foxp3 expression in CD4+CD25+ T cells of peripheral blood mononuclear cells and oral lesions in patients diagnosed with OLP, who were grouped as OLP subtype, duration and relapse. Using quantitative polymerase chain reaction (qPCR), western blotting and immunohistochemistry, Foxp3 expression levels in explants of oral lesions and CD4+CD25+ T cells from 32 patients with OLP were measured and compared, with 10 healthy subjects as the control group. Foxp3 mRNA expression levels in the explants of oral lesions and circulating CD4+CD25+ T cells in patients with OLP were significantly higher than those in the control group (Pexpression was significantly lower in circulating CD4+CD25+ T cells and tissue explants compared to patients with reticular lesions (P1 year or with a history of relapse (Pexpression in OLP tissues was 36.24±18.92 and 10.44±6.51% in normal oral mucosa (P=0.019). Atrophic/erosive OLP lesions showed a higher proportion of Foxp3‑expressing cells than that of reticular OLP lesions (Pexpression in patients with OLP is associated with the severity and duration of the disorder, suggesting altered immune suppression in the development, clinical course and responsiveness to treatment.

  6. Epstein–Barr virus and its association with rheumatoid arthritis and oral lichen planus

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    Pooja Adtani

    2015-01-01

    Full Text Available Context: Pathogenesis of autoimmune diseases (AD is one of a multifactorial milieu. A genetic predisposition, an immune system failure, hormonal imbalance and environmental factors play important roles. Among the many environmental factors, the role of infection is gaining importance in the pathogenesis of various autoimmune disorders; among them, Epstein–Barr virus (EBV plays a pivotal role. Literature states an association of various AD with EBV namely multiple sclerosis, autoimmune thyroiditis, systemic lupus erythematous, oral lichen planus (OLP, rheumatoid arthritis (RA, autoimmune hepatitis, Sjögren's syndrome and Kawasaki disease; among these, the most commonly occurring are OLP and RA. Aim: Considering the frequency of occurrences, our aim was to perform a qualitative analysis of EBV viral capsid antigen (EBV VCA IgG in the sera of patients with RA, OLP and establish a comparison with normal. Settings and Design:In-vitro experiment in a research laboratory. Subjects and Methods: Five-milliliter blood sample was collected from 25 patients diagnosed with RA and OLP. Serum was separated and EBV VCA IgG antibody titer was detected using NovaTec EBV VCA IgG ELISA kit. Statistical Analysis Used: Chi-square test. Results: Six out of 25 subjects with RAand 4 out of 25 subjects with OLP tested positive for EBV VCA IgG. Conclusions: Both environmental and genetic factors are important contributory components for autoimmune conditions. Screening for viral etiology would improve the efficacy of conventional treatment and reduce the risk of relapses.

  7. Phenotypic variability and therapeutic implications of Candida species in patients with oral lichen planus.

    Science.gov (United States)

    Arora, S; Verma, M; Gupta, S R; Urs, A B; Dhakad, M S; Kaur, R

    2016-01-01

    We investigated the prevalence and phenotypic variation of Candida species in oral lichen planus (OLP) and the therapeutic implications of our findings. Eighty patients with clinically and histopathologically confirmed cases of OLP (64 non-erosive, 16 erosive) and a control group of 80 healthy individuals with no predisposing factors for oral candidiasis were examined for evidence of Candida infection. Oral swabs and smears were obtained for cytology and culture. Identification, speciation and antifungal susceptibility tests of Candida isolates were performed using an automated microbial identification system. Fifty percent of erosive OLP cases, 28% of non-erosive cases and none of the controls showed evidence of Candida. Candida albicans was found predominantly in non-erosive OLP, while other Candida species were predominate in erosive OLP. Non-Candida albicans isolates (C. glabrata, C. krusei) were resistant to the commonly used antifungals, clotrimazole and fluconazole. Candida infection is common in cases of OLP. We recommend antifungal sensitivity testing prior to antifungal therapy for the erosive form of OLP.

  8. Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus

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    Zeinab A El Ashmawy

    2015-01-01

    Full Text Available Background: Cathepsin L is a member of papain superfamily. It seems to promote T-cell survival, selection maturation in the thymus and enhance the antigen presentation. Cathepsin L plays an important role in tumor necrosis factors (TNF-α induced cell death. Also it degrades the tight junction between cornedesomses in the epidermis. Elevated expression of cathepsin L has been found in many inflammatory and neoplastic diseases. Objective: The aim of this study was to determine immunohistochemical expression of cathepsin L in atopic dermatitis (AD and lichen planus (LP patients in order to evaluate its role in the pathogenesis of both diseases. Materials and Methods: This study included 15 patients with AD (Group I, 15 patients with LP (Group II, in addition to 10 healthy skin specimens served as controls (Group III. Punch biopsies were taken from lesional skin of the patients and controls for immunohistochemical detection of cathepsin L expression. Results: Highly significant increase was found in cathepsin L expression in AD and LP patients compared to controls [P = 0.001]. Conclusion: Cathepsin L could be implicated as an important protease in the pathogenesis of AD and LP. It could be a useful marker for assessing AD severity.

  9. The frequency and malignant transformation rate of oral lichen planus and leukoplakia--a retrospective study.

    Science.gov (United States)

    Brzak, Bozana Loncar; Mravak-Stipetić, Marinka; Canjuga, Ivana; Baricević, Marinka; Balicević, Drinko; Sikora, Miroslav; Filipović-Zore, Irina

    2012-09-01

    The aim of this retrospective study was to determine the frequency and malignant transformation rate of oral lichen planus and leukoplakia in a large group of oral medicine patients. Study included 12 508 patients who were referred between 1998 and 2007 to the Department of Oral Medicine. The frequency of OLP was 4.30%, leukoplakia 1.11%, and combined diagnoses 0.14%. In primary biopsies dysplasia was found in 12.96% of patients with leukoplakia and not in one with OLP and combined lesions. The highest frequency of leukoplakia was found in smokers. Women were found as predominant sufferers of both diseases and their combination. During the observed period often years malignant transformation of OLP was not detected, unlike leukoplakia where it was 0.64%. The frequency of OLP and leukoplakia in our study are comparable to other similar studies. The highest frequency of malignant transformation was observed in those patients who did not respond to our invitation to regular check-up. It is therefore neccessary to perform a detailed examination of the oral cavity in these patients and to raise patients awareness of the disease and the importance of regular follow-up.

  10. Issues related to diagnosing oral lichen planus among oral pathologists in South India: A pilot survey.

    Science.gov (United States)

    Sanketh, D Sharathkumar; Srinivasan, Samuel Raj; Patil, Shankargouda; Ranganathan, Kannan

    2016-10-26

    In the present study, we simulated clinical scenarios by explicitly describing the history and clinical and histological features of hypothetical patients presenting with oral lichen planus (OLP), oral lichenoid lesion, and epithelial dysplasia in a self-designed questionnaire. By doing so, we aimed to elicit a diagnosis from oral pathologists and trainees, analyze their responses, appraise issues, and propose solutions regarding the diagnosis of OLP. The questionnaire was distributed to 100 oral pathologists and trainees in South India. Six questions were designed to assess awareness of the diagnostic aspects of OLP. Ten questions were hypothetical clinical scenarios (HCS) devised to evaluate respondents' knowledge of diagnostic guidelines and the criteria used by the respondents to render a diagnosis. There were 60 of 100 responses to the questionnaire. More than half the respondents were aware of the World Health Organization and modified guidelines of OLP. We observed considerable variations in diagnoses for the HCS. Our study illustrates the ambiguity in rendering an accurate diagnosis, despite adequate guidelines. Based on the responses for the HCS, we hypothesized that changes in the distribution (unilateral or bilateral) and clinical characteristic of OLP, and habits of patients, have a significant bearing on the clinical and final diagnoses of the lesion. © 2016 John Wiley & Sons Australia, Ltd.

  11. Why the general dentist needs to know how to manage oral lichen planus.

    Science.gov (United States)

    Price, Stephanie M; Murrah, Valerie A

    2015-01-01

    Oral lichen planus (OLP) is a frequently mismanaged chronic disease that requires care throughout a patient's life, and therefore a condition the general dentist must know how to manage. Patients with OLP often suffer considerable physical discomfort and an inability to perform proper oral hygiene, eventually resulting in poor periodontal health. In addition, these patients are confronted with the psychological stress of knowing that OLP is not curable. This is accompanied by a fear of other negative health developments, particularly oral cancer. The objective of this study was to identify major issues surrounding the management of OLP by the general dentist. A literature review of over 1100 articles was performed. An eclectic compilation of the issues revealed 12 major areas of concern. This article reviews those concerns and presents strategies for coping with the myriad signs, symptoms, and complications associated with this disease, as well as educational approaches and legal considerations. A rationale is provided to place the responsibility for the management of these patients under the person best positioned to coordinate care for this condition--the general dentist. A general dentist can contribute to the overall oral health of an OLP patient with timely diagnosis, effective treatment, thorough patient education, and the orchestration of efforts by a team of health care providers.

  12. Oral Lichen Planus: An Update on Etiology, Pathogenesis, Clinical Presentation, Diagnosis and Management.

    Science.gov (United States)

    Gupta, Sonia; Jawanda, Manveen Kaur

    2015-01-01

    The mouth is a mirror of health or disease, a sentinel or early warning system. The oral cavity might well be thought as a window to the body because oral manifestations accompany many systemic diseases. In many instances, oral involvement precedes the appearance of other symptoms or lesions at other locations. Oral lichen planus (OLP) is a chronic mucocutaneous disorder of stratified squamous epithelium of uncertain etiology that affects oral and genital mucous membranes, skin, nails, and scalp. LP is estimated to affect 0.5% to 2.0% of the general population. This disease has most often been reported in middle-aged patients with 30-60 years of age and is more common in females than in males. The disease seems to be mediated by an antigen-specific mechanism, activating cytotoxic T cells, and non-specific mechanisms like mast cell degranulation and matrix metalloproteinase activation. A proper understanding of the pathogenesis, clinical presentation, diagnosis of the disease becomes important for providing the right treatment. This article discusses the prevalence, etiology, clinical features, oral manifestations, diagnosis, complications and treatment of oral LP.

  13. Tantangan dalam Perawatan Oral Lichen Planus pada Pasien Diabetes Melitus (Laporan Kasus

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    Ravina Naomi Tarigan

    2012-10-01

    Full Text Available Oral lichen planus (OLP is a chronic inflammatory condition that effects oral mucous membranes with a variety of clinical presentations including reticular, atrophic, plaque and ulcerative lesions. Corticosteroid is one of the effective therapy for OLP in reducing the sign and symptoms of this disease, but this therapy have a serious side effect, therefore to administering one must consider the patient’s systemic condition. We reported a case of OLP in 52 years old female patient who has no history of diabetes mellitus and unknown glucose level. Management of this patient included application of corticosteroid swish, topical 0.05% clobetasol propionate and 0,1% triamcinolone acetonide, antimycotics, improvement the oral hygiene status and referral to internal medicine specialist. The next treatments plan challenging because unstable blood glucose level which in turn effects the drug choice and teeth extraction plan. We concluded that the treatment of OLP requires a complete assessment of medical status and lab studies specially on the first visit so the drug selection with corticosteroid therapy and the treatment planning of predisposing factor are effective in reducing the sign and symptoms of OLP with minimum systemic side effect.DOI: 10.14693/jdi.v16i1.19

  14. Salivary Basic Fibroblast Growth Factorin Patients with Oral Squamous Cell Carcinoma or Oral Lichen Planus

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    Gorugantula, Lakshmi Mitreyi; Rees, Terry; Plemons, Jacqueline; Chen, Huey-Shys; Cheng, Yi-Shing Lisa

    2012-01-01

    Objective To gather preliminary data concerning the feasibility of using salivary basic fibroblast growth factor (bFGF) for detecting development of oral squamous cell carcinoma (OSCC) in oral lichen planus (OLP) patients, and in OSCC patients whose disease was in remission. Study Design Saliva samples were collected from five patient groups: newly diagnosed OSCC patients; OSCC patients in remission; OLP patients in disease-active state; OLP patients in disease-inactive state; and normal controls. Salivary bFGF levels were determined by ELISA, and data was analyzed using the Mann Whitney U test. Results Salivary bFGF levels were significantly elevated in newly diagnosed OSCC patients compared with OSCC remission patients, disease-active OLP patients, and normal controls. No significant difference was found between newly diagnosed OSCC patients and disease-inactive OLP patients. Conclusion Our results suggested that salivary bFGF might be a potential biomarker for detecting OSCC development in OSCC patients in remission, but not in OLP patients. PMID:22769407

  15. Psychoneuroimmunology in oral biology and medicine: the model of oral lichen planus.

    Science.gov (United States)

    Prolo, Paolo; Chiappelli, Francesco; Cajulis, Elaina; Bauer, Janet; Spackman, Susan; Romeo, Horacio; Carrozzo, Marco; Gandolfo, Sergio; Christensen, Russell

    2002-06-01

    Rheumatoid arthritis involves psychoneuroendocrine-immunopathological comorbidities. In the stoma, patients with rheumatoid arthritis frequently show signs of periondontal disease consequent to elevated levels of crevicular proinflammatory cytokines. It is not clear whether rheumatoid arthritis may manifest in association with immunopathological manifestations of the oral soft mucosa. Oral lichen planus (OLP), first described by E. Wilson in 1859, is a T-cell-mediated inflammatory disease whose lesions characteristically lack B cells, plasma cells, immunoglobulin. or complement. It is increasingly well characterized and recognized as a model for psychoneuroimmunology research in oral biology and medicine. To date, we have shown an association between changes in hypothalamic-pituitary-adrenal (HPA) regulation, systemic markers of cellular immunity and mood states, with clinical stages of OLP (i.e., atrophic vs. erosive vs. bullous lesions). We report significant associations (p < 0.05) between the stage of OLP, HPA deregulation, and altered distribution and functional responses of naïve CD4(+) cells. We emphasize the need to study in greater details the psychoneuroendocrine-immune inter-relationships in OLP, and we propose a novel neuroimmune hypothesis for OLP.

  16. Histopathological analysis of apoptotic cell count and its role in oral lichen planus

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    Vidya G Doddawad

    2014-01-01

    Full Text Available Apoptosis is a process of genetically programmed cell death by which senescent, DNA-damaged and diseased cells are eliminated from the body. Aim of the Study: To identify and count the number of apoptotic cells in oral lichen planus (OLP and correlate with the degree of keratinization, thickness of epithelium and thickness of lymphocytic infiltration of OLP. Materials and Methods: The study comprised 40 diagnosed cases of OLP. Sections were stained with hematoxylin and eosin to identify and count the number of apoptotic cells. Measurement of other histopathological parameter of OLP such as degree of keratinization, thickness of epithelium and thickness of lymphocytic infiltration was done by using stage micrometer and eyepiece graticule. Statistical analysis was done to understand the correlation between apoptotic cells and histopathological features of OLP. Result: The result showed that the number of apoptotic cells increased, with an increase in thickness of lymphocytic infiltration and degree of keratinization, but there was a decrease in the epithelial thickness. Conclusion: Further immunological and molecular studies are required for a stronger evidence in correlating apoptotic cell and histological parameters of OLP.

  17. EFFECTIVENESS EVALUATION OF COMPREHENSIVE TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH ORAL LICHEN PLANUS BY MONITORING OF LOCAL IMMUNITY INDICES

    OpenAIRE

    YELISEYEVA O.V.; SOKOLOVA I.I.

    2015-01-01

    Relevance. Changes in the oral mucosa, parodontium tissues are in most cases clinical and sometimes only signs of disorders in functioning of different organs and systems. Lichen planus is one of the most wide-spread and manifest as for clinical implications diseases of the oral mucosa. In this regard the goal of our research is assessment of sIgA in the oral fluid, C3 components of the complement, activity of lysozyme and beta-lysins in patients suffering from CGP and lichen planus before an...

  18. Lichen planus-like lesions as the first manifestation of adult T-cell leukaemia/lymphoma.

    Science.gov (United States)

    Sumida, Hayakazu; Sugaya, Makoto; Kamata, Masahiro; Suga, Hiraku; Miyagaki, Tomomitsu; Ohmatsu, Hanako; Fujita, Hideki; Sato, Shinichi

    2013-07-06

    Cutaneous involvement is frequent in adult T-cell leukaemia/lymphoma (ATLL), a peripheral T-cell neoplasm caused by human T-cell lymphotropic virus type I (HTLV-I). Patients with ATLL manifest different types of skin lesions, including nodules, plaques, ulcers, erythroderma and purpura. It has been reported that this type of skin eruption is an independent prognostic factor for ATLL. We report here a rare case of a 62-year-old Japanese woman with smouldering-type ATLL, first manifested by lichen planus-like skin lesions on the lower leg. This case report highlights the multiplicity of skin manifestations in ATLL.

  19. Pharmacotherapy of Oral Lichen Planus%口腔扁平苔癣的药物治疗

    Institute of Scientific and Technical Information of China (English)

    王浩; 高淑兰

    2004-01-01

    @@ 口腔扁平苔癣(Oral Lichen Planus,OLP)是口腔粘膜慢性表浅性炎症疾病, 是口腔常见粘膜病,目前OLP病因与发病机理仍不清楚,治疗方法也比较多,但无特效疗法 ,近年来口腔扁平苔癣的药物治疗有如下几个方面.

  20. Syndrome Differentiation and Treatment Experience of Lichen Planus%扁平苔藓证治经验

    Institute of Scientific and Technical Information of China (English)

    周宝宽

    2011-01-01

    目的:总结周宝宽主任医师辨证论治扁平苔藓经验.方法:以医案形式阐述扁平苔藓的病因病机、证型、治法、方药.结果:病因病机为风湿热邪侵袭肌肤,阻滞经络;肝郁气滞,脾失健运,湿热火毒内生;肝肾阴虚,虚火上炎;内外因相合,蕴结肌肤;上述诸因阻于皮肤、黏膜导致肌肤失养形成风热相搏证、血虚风燥证、肝郁气滞证、阴虚内热等证.治疗原则为疏风、清热、利湿、解毒、疏肝、活血、化瘀、滋阴、降火等.常用方剂为消风散、逍遥散、当归饮子、知柏地黄汤.结论:辨证论治扁平苔藓疗效显著.%Objective: To summarize syndrome differentiation and treatment experience of lichen planus in clinic. Methods: Discuss etiopathogenisis, pathogenesis, pattern of syndrome, method of treatment, formulas and tnedicinals based on medical records. Results : Etiopathogenisis and pathogenesis of lichen planus are wind dampness and heat injury muscle and skin, blocked on meridians; stagnation of QI due to depression of the liver, dys-splenism, damp-heat and virulent fire produced from the interior; hepatic and renal yin deficiency, hyperactivity of deficient fire;coincide of exterior and interior evil, gathering on muscle and skin; those causes blocked in skin and blocked result in failure of skin and muscle to be nourished, generate syndrome of wind-heat fighting, syndrome of blood deficiency wind-dryness syndrome, syndrome of stagnation of QI due to depression of the liver, syndrome of yin asthenia generating intrinsic heat. Treatment principles of lichen planus are, eliminating wind,eliminating heat, damp elimination, neutralize poison, disperse the depressed liver-energy, promoting blood flow, resolve stasis, nourish yin, downbear fire, etc. Frequently used decoction is Xaiofeng Yin, Danggui Yinzi, Zhibai Dihaung Tang. Conclusions:Syndrome differentiation and treatment shows a better therapeutic effect for lichen planus.

  1. Lichen planus-like drug reaction associated with recombinant human growth hormone therapy in a child patient with Turner syndrome.

    Science.gov (United States)

    Soares, Mariana Quirino Silveira; Mendonca, Elismauro Fancisco

    2016-01-01

    Turner syndrome (TS) is a genetic disease with an incidence rate of between 1:2000 and 1:5000 live female births. The treatment of TS differs according to age and Recombinant Human Growth Hormone (RHGH) therapy is usually given for the treatment of short stature in girls with TS in childhood. We describe the first case of a TS patient who presented with a clinical picture compatible with oral and palmoplantar lichen planus-like reaction during RHGH therapy; spontaneous remission occurred after therapy suspension.

  2. Lupus erythematosus and lichen planus overlap syndrome: a case report with a rapid response to topical corticosteroid therapy

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    Gulsen Tukenmez Demirci

    2011-11-01

    Full Text Available Lupus erythematosus (LE and lichen planus (LP may occur as an overlap syndrome. We report the clinical characteristics of a young man with lesions diagnosed as LE and LP by histopathological and direct immunoflurosence examinations. We achieved remarkable clinical response from the treatment with topical corticosteroids and no recurrence was seen in a 6 months of follow up time. We found this case interesting because of the rapid improvement with corticosteroid and discussed if there is a real overlap or a coexistence according to the literature.

  3. A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus

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    Nagao Yumiko

    2012-04-01

    Full Text Available Abstract Background The aims of this study were to assess the prevalence of hepatitis C virus (HCV infection in Japanese patients with oral lichen planus and identify the impact of amino acid (aa substitutions in the HCV core region and IFN-sensitivity-determining region (ISDR of nonstructural protein 5A (NS5A associated with lichen planus. Methods In this retrospective study, 59 patients (group 1-A with oral lichen planus among 226 consecutive patients who visited our hospital and 85 individuals (group 1-B, controls with normal oral mucosa were investigated for the presence of liver disease and HCV infection. Risk factors for the presence of oral lichen planus were assessed by logistic regression analysis. We compared aa substitutions in the HCV core region (70 and/or 91 and ISDR of NS5A of 12 patients with oral lichen planus (group 2-A and 7 patients who did not have oral lichen planus (group 2-B among patients (high viral loads, genotype 1b who received interferon (IFN therapy in group1-A. Results The prevalence of anti-HCV and HCV RNA was 67.80% (40/59 and 59.32% (35/59, respectively, in group 1-A and 31.76% (27/85 and 16.47% (14/85, respectively, in group 1-B. The prevalence of anti-HCV (P P Conclusion We observed a high prevalence of HCV infection in patients with oral lichen planus. Longstanding HCV infection, hypoalbuminemia, and smoking were significant risk factors for the presence of oral lichen planus in patients. It is advisable for Japanese patients with lichen planus to be tested for HCV infection during medical examination.

  4. Comparison of the Effect of Combination of Triamcinolone Acetonide and Vitamin A Mouthwash with Triamcinolone Mouthwash Alone on Oral Lichen Planus

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    Zohreh Dalirsani

    2010-03-01

    Full Text Available Background and aims. Lichen planus is a relatively common mucocutaneous disease, with an unknown etiology. There is no complete cure for oral lichen planus (OLP, but some drugs, including corticosteroids, retinoids, cyclosporine and antibiotics are commonly used for treatment of OLP. The aim of the present study was to compare the effect of combination of triamcinolone and vitamin A mouthwash with triamcinolone mouthwash alone on OLP. Materials and methods. Twenty OLP patients were randomly divided into two groups of 10. The experimental group was treated with combination of triamcinolone and vitamin A mouthwash and the control group was treated with triamcinolone-containing mouthwash alone. The patients were examined once every two weeks and the lesion size, pain and burning sensation were recorded based on visual analogue scale during a two-month period. Data were analyzed by MannWhitney U test using SPSS software. Results. The use of combination of triamcinolone-vitamin A mouthwash was effective in decreasing the pain and burning sensation of OLP (P = 0.012. Decrease in pain and burning sensation were similar in both groups (P = 0.73. The use of combination of triamcinolone-vitamin A mouthwash led to a decrease in the size of keratotic, atrophic and erosive OLP lesions (P = 0. Decrease in the size of the lesions was significantly greater in the study group compared to the control group (P = 0.029. Conclusion. The use of combination of triamcinolone-vitamin A mouthwash is effective in decreasing the size of keratotic, atrophic or erosive lesions.

  5. Clinicopathological Profile and Malignant Transformation in Oral Lichen Planus: A Retrospective Study.

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    Bandyopadhyay, Alokenath; Behura, Shyam Sundar; Nishat, Roquaiya; Dash, Kailash Chandra; Bhuyan, Lipsa; Ramachandra, Sujatha

    2017-01-01

    The aim of this study was to analyze the histopathologically diagnosed cases of oral lichen planus (OLP) in terms of age, gender, clinical variant, site, hyperpigmentation, systemic illness, grade of dysplasia, and associated malignant transformation. This study also intended to do a review of reported cases of OLP with malignant transformation. One hundred and forty-three cases of histopathologically diagnosed OLP between 2010 and 2016 were retrospectively reviewed. Demographic and clinicopathological data including malignant transformation were obtained. The data obtained were analyzed using the Statistical Package for the Social Sciences (SPSS) software for Windows version 20.0 (IBM SPSS, SPSS Inc., Chicago, IL, USA). A review of published literature on OLP with malignant transformation was also done from 1988 to 2017 and tabulated. OLP in this study showed a male predilection with most of the patients in the third decade. The buccal mucosa (bilateral presentation) was the most common site (79.72%), and reticular type was the most common clinical type (79.02%) followed by erosive type (20.98%). The majority (92.31%) of cases were diagnosed with OLP without dysplasia. The rest (7.69%) of dysplastic cases were predominantly seen in the buccal mucosa of 58 years and above, female patients manifesting mainly as erosive type. Two patients (1.4%) previously diagnosed clinically and histopathologically as OLP developed oral squamous cell carcinoma. The present investigation revealed the predominance of OLP among middle-aged male population and the prevalence of bilateral involvement of buccal mucosa. Two of our cases showed malignant transformation over an average period of 3.5 years. The outcome of this study emphasizes the role of clinical follow-up of patients with OLP.

  6. Gene expression of miRNA-138 and cyclin D1 in oral lichen planus.

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    Ghallab, Noha A; Kasem, Rehab Fawzy; El-Ghani, Safa Fathy Abd; Shaker, Olfat G

    2017-03-08

    This study aimed to evaluate microRNA-138 (miR-138) gene expression and its target cyclin D1 (CCND1) gene and protein expression in oral lichen planus (OLP) mucosa in an attempt to investigate their possible roles in OLP immunopathogenesis. Sixty oral biopsy specimens were harvested from 30 healthy subjects and 30 OLP patients, subdivided into reticular, atrophic, and erosive groups (n = 10 each). Samples were subjected to quantitative real-time polymerase chain reaction analysis for quantification of miR-138 and CCND1 relative gene expression and immunohistochemical analysis to determine CCND1 protein expression. Samples from OLP patients had a significant underexpression of miR-138 gene and overexpression of CCND1 at both gene and protein levels compared to normal mucosa samples. The lowest levels of miR-138 expression were observed in atrophic and erosive OLP compared to reticular OLP, and the highest levels of CCND1 gene and protein expression were in atrophic OLP. An inverse correlation was demonstrated between the miR-138 expression and both CCND1 gene and protein expression in OLP patients. A significant positive correlation between CCND1 gene and protein expression was also observed. Downregulation of miR-138 increases the gene and protein expression of its potential target CCND1 in OLP mucosa which might have a pivotal role in the disease pathogenesis. This research implied that miR-138 may have a role in identification of symptomatic OLP lesions. MiR-138 might be considered as a potential tool in future OLP molecular therapy.

  7. Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus.

    Science.gov (United States)

    Adami, Guy R; Yeung, Alexander C F; Stucki, Grant; Kolokythas, Antonia; Sroussi, Herve Y; Cabay, Robert J; Kuzin, Igor; Schwartz, Joel L

    2014-03-01

    Oral lichen planus (OLP) is a disease of the oral mucosa of unknown cause producing lesions with an intense band-like inflammatory infiltrate of T cells to the subepithelium and keratinocyte cell death. We performed gene expression analysis of the oral epithelium of lesions in subjects with OLP and its sister disease, oral lichenoid reaction (OLR), in order to better understand the role of the keratinocytes in these diseases. Fourteen patients with OLP or OLR were included in the study, along with a control group of 23 subjects with a variety of oral diseases and a normal group of 17 subjects with no clinically visible mucosal abnormalities. Various proteins have been associated with OLP, based on detection of secreted proteins or changes in RNA levels in tissue samples consisting of epithelium, stroma, and immune cells. The mRNA level of twelve of these genes expressed in the epithelium was tested in the three groups. Four genes showed increased expression in the epithelium of OLP patients: CD14, CXCL1, IL8, and TLR1, and at least two of these proteins, TLR1 and CXCL1, were expressed at substantial levels in oral keratinocytes. Because of the large accumulation of T cells in lesions of OLP it has long been thought to be an adaptive immunity malfunction. We provide evidence that there is increased expression of innate immune genes in the epithelium with this illness, suggesting a role for this process in the disease and a possible target for treatment. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

    Institute of Scientific and Technical Information of China (English)

    Abdullah Seckin Ertugrul; Ugur Arslan; Recep Dursun; Sema Sezgin Hakki

    2013-01-01

    Oral lichen planus (OLP) is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 (18 chronic periodontitis (OLPP) and 9 gingivitis (OLPG)) patients diagnosed with OLP along with 26 (13 chronic periodontitis (HP) and 13 gingivitis (HG)) healthy non-OLP patients. The multiplex polymerase chain reaction (PCR) with subsequent reverse hybridization method (micro-IDent) was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients (OLPG and OLPP) were 18.5%, 85.1%, 81.4%, 88.8%and 74%, respectively. Meanwhile, in the non-OLP patients (HG and HP), these values were 7.6%, 50%, 46.1%, 73%and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens’ percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathogenic microorganisms in the progress of periodontal diseases of OLP.

  9. Intracellular Ca2+ and related proteins in patients with oral lichen planus.

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    Ma, Jiang-Min; Wang, Ran; Xu, Juan-Yong; Fan, Yuan

    2016-04-01

    Oral lichen planus (OLP) is suggested to be a T cell-mediated chronic inflammatory oral mucosal disease. Gene expressed in the oligodendrocyte lineage-myelin basic proteins (Golli-MBP) and stromal interaction molecule 1 (STIM1) are important in the activation and function of T lymphocytes. This study aimed to analyze and compare the expression of Golli-MBP and STIM1 between OLP patients and healthy controls and to analyze the level of intracellular Ca(2+), which is involved in lymphocyte activation. The Ca(2+) fluorescent probe, Fluo-3/AM, was used to test the level of intracellular Ca(2+) in patients with OLP and healthy controls peripheral blood lymphocytes. Golli-MBP and STIM1 mRNA and protein levels were analyzed using quantitative real-time PCR and Western blot, respectively. Following lymphocyte activation, the intracellular Ca(2+) in OLP patients was markedly lower than that in the control group (P < 0.001). In OLP patients, the expression of Golli-MBP mRNA and protein was significantly upregulated compared to those of the control group (P < 0.001). Similarly, OLP patients showed markedly upregulated levels of STIM1 mRNA expression (P < 0.01) and protein compared to healthy controls. The intracellular Ca(2+) of OLP patients was markedly lower than that of healthy controls. This evidence may indicate that Ca(2+) signaling pathways in OLP patients are abnormal. The overexpression of Golli-MBP and STIM1 may play a role in the pathogenesis of OLP.

  10. Human Papillomavirus-Induced Squamous Intraepithelial Lesions in Vulvar Lichen Planus.

    Science.gov (United States)

    Regauer, Sigrid; Eberz, Barbara; Reich, Olaf

    2016-10-01

    Approximately 50% of vulvar cancers arise after transforming infections with human papilloma virus (HPV) via the precursor squamous intraepithelial lesion (SIL). Lichen planus (LP)-associated vulvar cancers are typically HPV negative and arise via the precursor differentiated vulvar intraepithelial neoplasia (d-VIN). An index case of vulvar high-grade squamous intraepithelial lesion (H-SIL) in an LP patient prompted this 12-year retrospective analysis about frequency of HPV-induced SIL in 785 biopsies of 584 patients with vulvar LP. All SIL were analyzed for p53 and p16 overexpression and for presence of DNA of 32 HPV subtypes. Nine (1.6%) of 584 women with papular (3) and mucosal "erosive" LP (6) presented with H-SIL (7) and low-grade SIL (2). All SILs harbored HPV16-DNA and showed p16-overexpression. Concomitant immune suppression included T-suppressor lymphocyte deficit (1), systemic (1), and topical (2) cortisone therapy. H-SILs regressed spontaneously (1) or after imiquimod therapy (3). Three women with erosive LP discontinued imiquimod because of side effects and had laser destruction (1), skinning vulvectomy (1), and surgery (1) for definitive treatment. Two women have recurrent vulvar SILs, and 1 woman progressed to invasive SCC. In the same patient population, 16 of 584 women had a d-VIN, and 9 of 16 with progression to SCC. H-SILs in vulvar LP are rare and may occur in the setting of risk factors. If clinical suspicion arises, biopsy and histological examination assist in correct etiologic classification of a precancerous lesion and subsequent therapy decisions. The minimal risk for H-SIL development in vulvar LP patients should not preclude therapy of LP.

  11. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications.

    NARCIS (Netherlands)

    Meij, van der E.H.; Waal, van der I.

    2003-01-01

    INTRODUCTION: Confirmation of a clinical diagnosis of oral lichen planus (OLP) by means of histopathologic study of a biopsy specimen is generally advised. However, hardly any data exist about the correlation between clinical and histopathologic diagnoses of OLP. The aim of the present investigation

  12. Efficacy of low-level laser therapy in management of symptomatic oral lichen planus: a systematic review.

    Science.gov (United States)

    Al-Maweri, Sadeq Ali; Kalakonda, Butchibabu; Al-Soneidar, Walid A; Al-Shamiri, Hashem Motahir; Alakhali, Mohammed Sultan; Alaizari, Nader

    2017-08-01

    Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology and indefinite cure. This systematic review assessed the efficacy of low-level laser therapy in the treatment of symptomatic OLP. Electronic databases (PubMed, Scopus, and Web of Science) were searched from date of inception till and including December 2016, using various combinations of the following keywords: oral lichen planus, laser therapy, low-level laser therapy, and phototherapy. Owing to heterogeneity of data, no statistical analyses were conducted. Initially, 227 publications were identified. After selection, only six studies were included in this systematic review. In these studies, the laser wavelengths, power output, and duration of irradiation ranged between 630-980 nm, 20-300 mW, and 10 s-15 min, respectively. All of the included studies found laser to be effective in management of OLP, without any reported adverse effects. The results of the included studies confirm that low-level laser therapy is effective in management of symptomatic OLP and can be used as an alternative to corticosteroids. However, due to variety of methods and substantial variations in laser parameters among these studies, more randomized clinical trials with large sample sizes are highly warranted.

  13. Liquen plano: Revisión de la literatura actual Oral lichen planus: A review of literature

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    P. Matesanz-Pérez

    2009-04-01

    Full Text Available Objetivo: Proporcionar información actualizada acerca del liquen plano oral, prestando atención especial a su posible malignización y a su relación con el cáncer oral. El liquen es una enfermedad mucocutánea con una relevancia particular en la cavidad oral, no sólo debida a su prevalencia, sino también debida al hecho de estar englobada dentro de los denominados "enfermedades o estados premalignos". La relación del liquen plano con el cáncer oral aumenta la necesidad de revisar la literatura, para así comprender cuánto puede hacer el clínico al respecto, y aprender cómo manejar esta patología.Aims: To provide updated knowledge about oral lichen planus, paying especial attention to its possible malignant transformation and the relationship with oral cancer. Oral lichen planus is a mucocutaneous disorder with particular relevance in the oral cavity, not only due to its prevalence, but due to the fact of belonging to the group of "premalignant lesions or states". The relationship that this pathology has with oral cancer increases the need for literature reviewing so as to learn what the practitioner can do about it and how to manage it.

  14. P53 and bcl-2 immunoexpression in patients with oral lichen planus and oral squamous cell carcinoma

    Science.gov (United States)

    Leyva-Huerta, Elba R.; Rojo-Botello, Rebeca E.; Vega-Memije, Elisa

    2012-01-01

    Objective: The aim of this study was to determine by immunohistochemistry the presence and significance of p53 and bcl-2 proteins in oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). Study Design: We used 21 cases diagnosed as OLP 16 diagnosed as OSCC and four normal gingival biopsies taken from healthy patients were used as controls. Slides were processed for immunohistochemistry using anti-p53 and anti-bcl-2 monoclonal antibodies. Results: We found p53 immunoexpression in 71.4% OLP cases and 68.7% OSCC cases, with no immunoexpression in control cases. Bcl-2 was negative for all OLP and OSCC cases, and mild positivity was observed in normal tissue. We found significant correlation among p53 expression and OSCC malignancy. Conclusions: Our results suggest that TP53 system mainly promotes a hyperproliferative state by cell cycle arrest of the OLP epithelial cells for repairing damaged DNA nor apoptosis and that anti-apoptotic action of bcl-2 is not important in this disease. Key words:Oral lichen planus, oral squamous cell carcinoma, p53, Bcl-2, carcinogenesis, malignant transformation. PMID:22549684

  15. COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    Tie-Jun Li; Jun Cui

    2013-01-01

    Objective:To observe cyclooxygenase (COX)-2 expression in normal oral mucosa (NOM), oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) and explore its significance in the incidence of oral cancer. Methods: The immunohistochemical method and RT-PCR method were applied to detect the expression of COX-2 and MMP-7 in 10 cases with NOM, 33 cases of with OLP and 38 cases with OSCC. Results: The expression of COX-2 mRNA in OSCC tissues (68.4%, 26/38) was significantly higher than in the OLP (24.2%, 8/33) and NOM (0.0%, 0/10) (P<0.01). The expression of MMP-7 mRNA in OSCC tissues (65.8%, 25/38) was significantly higher than in the OLP (30.3%, 10/33) and NOM (0.0%, 0/10) (P<0.01). The expression of MMP-7 in OLP was significantly higher than in the NOM (P<0.05). There was no significant expression of COX-2 protein in NOM, and the positive rate was 42.4% (14/33) and 89.5% (34/38) in OLP and OSCC group, respectively. The COX-2 expression in cancer tissues was significantly higher than in NOM and OLP (P<0.05). The MMP-7 protein expression in cancer tissues (84.2%, 32/38) was significantly higher than in NOM (10.0%, 1/10) and in OLP (42.4%, 14/33), and the positive rate in OLP was significantly higher than in NOM (P<0.01). The COX-2 expression was associated with clinical stage (P<0.05), the MMP-7 expression was associated with clinical stage and lymph node metastasis (P<0.05). The expressions of COX-2 and MMP-7 mRNA were positively correlated with OSCC. Conclusions:The abnormal expressions of COX-2 and MMP-7 are closely related to the biological behavior of OSCC, the MMP-7 may be induced by COX-2, and further lead to the invasion and metastasis of OSCC.

  16. Diagnóstico del liquen plano oral Diagnosis of the oral lichen planus

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    A. Blanco Carrión

    2008-02-01

    Full Text Available El objetivo de este trabajo es presentar los aspectos clínicos y patológicos necesarios para conocer mejor el liquen plano oral y poder diagnosticarlo correctamente. El diagnóstico se obtiene en primer lugar por el aspecto clínico de las lesiones. Se debe realizar siempre biopsia y estudio anatomopatológico para confirmar la sospecha clínica y realizar diagnóstico diferencial con otras entidades de apariencia clínica similar. Los pasos que debemos seguir para realizar un diagnóstico de certeza son: estudio de la clínica (anamnesis y exploración clínica, biopsia para estudio histopatológico y analítica sanguínea y determinación de la tensión arterial, buscando una posible relación con determinados procesos sistémicos. Se hará una inmunofluorescencia directa cuando haya que diferenciarlo de dermatopatías similares (lupus, penfigoide o pénfigo. En ocasiones podremos realizar un análisis estructural y otras pruebas diagnósticas.The aim of this work is to present the clinical and pathological necessary aspects to know better the oral lichen planus and to be able to diagnose it correctly. The diagnosis is obtained first by the clinical aspect of the injuries. It is necessary to realize always biopsy and histopathologyc evaluation to confirm the clinical suspicion and realize differential diagnosis with other entities of clinical similar appearance. The steps that we must follow to realize a diagnosis of certainty are: study of the clinic (anamnesis and clinical exploration, biopsy for histopathological study and analytical blood and determination of the blood pressure, looking for a possible relation with certain systemic processes. It will become a direct inmunofluorescence when it is necessary to differentiate it of similar disease (lupus, pemphigoid or pemphigus. In occasions we will be able to realize a ultraestructural analysis and other diagnostic tests.

  17. Salivary Interferon Gamma and Interleukin-4 Levels in Patients Suffering from Oral Lichen Planus

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    Hossein Malekzadeh

    2015-10-01

    Full Text Available Objective: Oral lichen planus (OLP is a chronic inflammatory disease. Immunological factor may act as etiological factor. The cellular immune cells such as T cells are important in pathogenesis. Interferon gamma (IFN-γ and interleukin 4 (IL-4 are secreted by T-helper 1 (Th1 and Th2, respectively. The aim of this study was to investigate the correlation between salivary levels of IFN-γ and IL-4 with OLP. Materials and Methods: This case control study included sixty three Iranian OLP patients who were selected from the Department of Oral Medicine of Ahvaz Jundishapur University of Medical Sciences from January to July 2013. An equal number of healthy volunteers were also selected as a control group. The OLP patients were then divided into two following sub-groups: reticular (n=30 and erythematous/ulcerative (n=33. All patients had no systemic disease and received no medication. IFN-γ and IL-4 levels in whole unstimulated saliva (WUS were measured using the enzyme-linked immunosorbent assay (ELISA test. Data analysis was done using t test, ANOVA, least significant difference (LSD test, and the Kruskal-Wallis test. Results: Reticular OLP patients showed higher salivary IFN-γ (7.74 ± 0.09 pg/ml and IL-4 (3.876 ± 0.05 pg/ml levels compared with the control group, indicating that difference was significant. Salivary IFN-γ/IL-4 ratio significantly increased compared with control group (P=0.042. Salivary IFN-γ and IL-4 levels between sub-groups (reticular and erythematous/ulcerative were not significantly different (2.6 ± 0.06 and 2.3 ± 0.05, respectively, P<0.05. Conclusion: Salivary IFN-γ and IL-4 levels were increased in OLP patients. An increase of salivary IFN-γ/IL-4 ratio in OLP patients showed that Th1 might have a dominant role in the OLP pathogenesis.

  18. Blaschko çizgileri dağılımlı lineer liken planus olgusu

    OpenAIRE

    Uçmak, Derya; Yeşilova, Yavuz; Gençoğlu, Metehan

    2011-01-01

    Lichen planus is an inflammatory disorder that may involve skin and mucous membranes. Linear lichen planus is a rare disorder occurring in approximately 0.2% of patients with lichen planus. We report a case of linear lichen planus on the upper extremity which lesions followed the lines of Blaschko. J Clin Exp Invest 2011; 2 (4): 430-432

  19. Cell proliferation in lichen planus of the buccal mucosa with special regard to a therapy with an aromatic retinoid (RO 10-9359). Proliferationsverhalten des oralen lichen planus unter besonderer Beruecksichtigung einer Therapie mit aromatischem Retinoid (RO 10-9359)

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, G.

    1982-01-01

    The proliferative activity of buccal mucosa epithelium in 16 patients suffering from oral lichen planus was studied by using (/sup 3/H)-thymidine labelling technique in vitro and histometric methods. Autoradiographic sections of two groups of lesions (12 with atrophic and 4 with acanthotic epithelium) were compared with the buccal mucosa of 19 healthy controls investigated in the same way. Determinations comprised separate and combined labelling indices of the basal and suprabasal progenitor compartment (LIsub(bas), LIsub(sbas), LIsub(total)) in relation to basal cells as well as to surface of the epithelium. The following results were obtained. The values of LIsub(total) per 100 basal cells were increased in both groups of lesions, whereby the relation of LIsub(bas):LIsub(sbas) shifted markedly to LIsub(bas), in particular in the atrophic lesions. When relating the total of labelled nuclei to surface length, however, an increase could be confirmed only in acanthotic lesions, whereas most atrophic lesions showed a decrease. This indicates an impaired capacity of the atrophic epithelium to maintain regenerative steady state. This imbalance could also be confirmed by counting the total of basal cells per surface length, which were significantly lowered in atrophic lesions as compared with acanthotic ones as well as normal mucosa. From the results it can be concluded that the renewal activity of the epithelium in atrophic lesions of lichen planus mucosae becomes virtually deficient, though determination of LIsub(total) referred to basal cells simulates a slight increase. Thus, for detecting intrinsic imbalances in the proliferative equilibrium of squamous epithelium, correlation of progenitor compartment labelling to external surface as the site of continuous cell loss is required.

  20. Two case reports of oral lichen planus in children%儿童口腔扁平苔藓病例报告2例

    Institute of Scientific and Technical Information of China (English)

    刘莉; 王珣; 蔡扬

    2016-01-01

    Oral lichen planus (OLP) is one of the common diseases of the oral mucosa, incidence of 1%-2%. It occurs in middle-age people,which is a rare disease in children [1] with few domestic literature reports. This article will re-port 2 cases of children's oral lichen planus, and discuss the etiology of children's oral lichen planus, onset ages, clinical manifestations and treatment methods.%口腔扁平苔藓(oral lichen planus,OLP)是口腔黏膜常见疾病之一,发病率为1%~2%,好发于中年人,儿童发病较为少见[1],国内只有极少的文献报告。本文将报告2例儿童口腔扁平苔藓,同时探讨儿童口腔扁平苔藓的病因、发病年龄、临床表现以及治疗方法。

  1. Treatment of lichen planus-lupus erythematosus overlap syndrome with acitretin and tacrolimus%阿维A联合他克莫司治疗扁平苔藓——红斑狼疮重叠综合征

    Institute of Scientific and Technical Information of China (English)

    刘佳玮; 刘洁; 曾跃平; 刘跃华; 孙秋宁

    2013-01-01

    报告阿维A联合他克莫司软膏封包治疗扁平苔藓-红斑狼疮重叠综合征1例.患者女,72岁.双足跟反复糜烂34年.皮肤科检查:双足跟水肿性红斑散在糜烂,皮损组织病理符合扁平苔藓组织病理表现.实验室检查:抗核抗体(ANA)(+),滴度1∶80,均质型,抗双链DNA抗体(+),抗SS-A抗体(+),滴度1∶4.诊断:扁平苔藓-红斑狼疮重叠综合征.给予口服阿维A30 mg/d,0.1%他克莫司软膏局部封包治疗,皮损好转明显.%A case of lichen planus-lupus erythematosus overlap syndrome treated with oral acitretin and tacrolimus occlusion is reported. A 72-year-old woman presented with recurrent erosions on her soles for 34 years. Skin examination showed erosions and edematous erythemas on both heels. Histological findings were consistent with lichen planus. Laboratory tests revealed a homogeneous pattern of ANA, with titer of 1 : 80. Anti-dsDNA antibody was positive. Anti-SS-A antibody was positive, with titer of 1 : 4. The patient was diagnosed as lichen planus-lupus erythematosus overlap syndrome. Treatment with o-ral acitretin (30 mg/d) and 0.1% tacrolimus occlusion was successful.

  2. Circumscribed lenticular anetoderma in an HIV-infected man with a history of syphilis and lichen planus.

    Science.gov (United States)

    Hunt, Raegan; Chu, Julie; Patel, Rishi; Sanchez, Miguel

    2011-10-15

    Anetoderma is an uncommon dermatosis that manifests as discrete foci of well-circumscribed, atrophic skin. The condition can be idiopathic or can be secondary to a number of associated cutaneous diseases. Whereas the pathophysiologic mechanisms remain unknown, anetoderma results from diminished elastic fibers in the dermis. We present an unusual case of localized, lenticular anetoderma in a man with HIV, a history of syphilis, and lichen planus. Both of these infections have been associated with anetoderma. Although his lesions are vaguely reminiscent of a variant of syphilitic anetoderma described in the 1930s, they are confined to a smaller anatomic distribution, differ in size, and have a papular appearance. As anetoderma can develop in the context of infectious disease, a diagnosis of anetoderma should trigger a thorough examination and evaluation for treatable concomitant illnesses.

  3. Efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus: a systematic review and meta-analysis.

    Science.gov (United States)

    Chamani, Goli; Rad, Maryam; Zarei, Mohammad Reza; Lotfi, Sodabeh; Sadeghi, Masoumeh; Ahmadi, Zahra

    2015-09-01

    This study was carried out to assess and compare the efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus (OLP). The Cochrane Central Register of Controlled Trials, PubMed, Scopus, Science Direct, Springer Journals, and Elsevier databases were searched using specific keywords relevant to the research question for articles published from 1998 to December 31, 2012. Finally, 15 articles that assessed the effects of tacrolimus, clobetasol, and pimecrolimus on improvements in OLP were reviewed. In addition, a meta-analysis of odds ratios (ORs) was carried out for data in 10 of the 15 articles. The results showed that the ORs for improvements in OLP in patients taking clobetasol or tacrolimus, compared with those taking placebo or other drugs, were 1.19 and 8.00, respectively. It appears that topical tacrolimus is an effective alternative to topical clobetasol and may be considered as a first-line therapy in the management of OLP.

  4. 口腔扁平苔藓治疗思路%Thoughts over the treatment for oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    张英; 康媛媛

    2008-01-01

    @@ 口腔扁平苔藓(oral lichen planus,OLP)是一种累及口腔黏膜且可反复发作的慢性炎症疾病,患病率为0.51%,在口腔黏膜疾病中居第2位.属常见病.皮肤和黏膜可单独或同时发病,病理表现相似:主要以口腔黏膜不同程度的角化异常、基底层细胞液化变性、上皮下结缔组织中淋巴细胞呈带状浸润为典型表现.因长期糜烂,病损有恶变现象,WHO将其列为癌前状态[1].

  5. 口腔扁平苔藓治疗进展%Development of study on treatment for oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    李洁婷; 柳志文

    2010-01-01

    口腔扁平苔藓(oral lichen planus,OLP)是口腔黏膜病中最常见且难以治愈的疾病之一.该病反复发作,可迁延终身,对患者身心造成很大痛苦,故寻找切实有效的治疗方法 是非常必要的.目前,国内外学者提出了很多治疗OLP的方法 ,主要有局部激素治疗、全身应用激素及免疫调节剂等方法 ,同时,中医中药治疗也取得了较好的疗效.本文主要就近年来国内外报道的OLP治疗进展做一综述.

  6. Oral lichen planus and epithelial dysplasia with lichenoid features: a review and discussion with special reference to diagnosis.

    Science.gov (United States)

    Sanketh, D SharathKumar; Patil, Shankargouda; Swetha, Balamukundan

    2016-07-21

    Despite guidelines for the diagnosis of oral lichen planus (OLP), there has been much difficulty and ambiguity in rendering a straightforward diagnosis. The root of the problem might arise in not following universal guidelines and being too rigid and unilateral in making a diagnosis. Because of its autoimmune pathogenesis, the dynamic nature of OLP has further fueled confusions. This has had repercussions in the form of controversies in its diagnosis, treatment protocols, research, and most importantly, its potentially malignant nature. Oral lichenoid dysplasia (OLD), an enigmatic entity, proposed by Krutchkoff and Eisenberg, has not found universal acceptance by the pathology community. The objective of the present review was to outline these debates and discuss ongoing controversies regarding OLD and uncertainties in the diagnostic criteria of OLP.

  7. Correlation of " in vivo" microcirculation and degeneration of the basal cells of the epithelium in lingual lichen planus

    Directory of Open Access Journals (Sweden)

    Scardina G

    2009-01-01

    Full Text Available Background: Oral lichen planus is an inflammatory chronic disease with an autimmune pathogenesis and unknown etiology that affects oral mucosa, with or without the involvement of the skin and other mucous membranes. The principal histological characteristics are the degeneration of the basal cell layer and the abnormal infiltration of inflammatory cells into the subepithelial layer of connective tissue. Objectives: This study is aimed to appraise if lingual lichen planus (LLP is sustained by alteration of the oral microcirculation and if this abnormal vascularisation increases the degeneration of basal keratinocytes and the disruption of the basement membrane. Materials and Methods: Fifteen patients with a histological diagnosis of LLP with higher degree of degeneration of the basement membrane, fifteen LLP patients with lower degree of basement membrane (BM degeneration and fifteen healthy patients were included in the study. The microcirculation of the left margin of the lingual mucosa of all the patients and subjects was analysed with the videocapillaroscopy. The following parameters were analyzed on each capillaroscopic image: c0 apillary loop length, loop diameter, and capillary density. The results obtained by videocapillaroscopy software were subjected to statistical analysis using Mann Whitney U-test (P < 0.001. Statistical analysis was performed using PAST software, v. 1.53. Results: Capillary density, loop length, and total diameter showed statistically significant differences between LLP patients with histologically lower degree of BM degeneration and healthy subjects and a meaningful significant difference between LLP patients with higher degree of BM degeneration. Conclusions: A remarkable increase in capillary density was showed by videocapillaroscopic exam. The increased value of the density could be associated with angiogenesis mechanism and it could be an indicator of the evolutionary condition of LLP. Videocapillaroscopy may be

  8. 白介素17和白介素35在扁平苔藓的表达和临床分析%Expressions of IL-17 and IL-35 in lichen planus and its clinical analysis

    Institute of Scientific and Technical Information of China (English)

    荣蓉

    2016-01-01

    目的 通过检测扁平苔藓患者组织病理的白介素17和白介素35的表达情况,探讨白介素17和白介素35在扁平苔藓的发病机制中的作用.方法 选取来本院皮肤性病科就诊的扁平苔藓患者36例,按照统计学原则随机选取正常人36例,将正常人和患者分为对照组和临床组,所有患者都经过皮肤病理学确诊,通过应用免疫组化法和DNA末端转移酶介导的原位缺口末端标记法测定白介素17和白介素35在扁平苔藓患者和正常人中的表达水平.结果 扁平苔藓组中白介素17和白介素35的表达率均高于正常对照组(P< 0.05).结论 白介素17和白介素35的高表达可能参与了扁平苔藓的发病机制.%Objective To explore the role of interleukin-17 and interleukin-35 in the pathogenesis of lichen planus detecting the expressions of histopathological of IL-17 and IL-35 in patients with lichen planus.Methods 36 patients with lichen planus treated at the department of dermatology at our hospital were selected as a clinical group and 36 healthy objects a control group.All the patients had been diagnosed by skin pathology.The expression levels of interleukin-17 and interleukin-35 in both groups were determined by immunohistochemical staining and DNA terminal transferase-mediated dUTP nick end labeling.Results The expressions of interleukin-17 and interleukin 35 were higher in the clinical group than in the control group (P<0.05).Conclusion The high expressions of interleukin-17 and interleukin-35 may be involved in the pathogenesis of lichen planus.

  9. Multiple lichen planus-like keratoses: Lichenoid drug eruption simulant and under-recognised cause of pruritic eruptions in the elderly.

    Science.gov (United States)

    Pitney, Lucy; Weedon, David; Pitney, Michael

    2016-02-01

    We present six cases of multiple eruptive lichen planus-like keratoses (LPLK), occurring in older individuals predominately confined to previously solar exposed areas. Diagnosis was often confounded by the frequent histological reporting of 'lichenoid drug reaction' (LDR), despite many of the patients being unmedicated. We review the literature regarding eruptive LPLK and reflect on their etiology, clinical aspects, management and importantly their clinicopathological differentiation from LDR.

  10. Clinical and Histologic Features Compared with AgNOR Count in Oral Leukoplakia, Erosive Lichen Planus, Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma

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    Sarbjeet Singh

    2006-01-01

    The aim of the study was to correlate and compare AgNOR count in speckled leukoplakia, oral lichen planus, oral submucous fibrosis and in oral squamous cell carcinoma and to assess if AgNOR count could contribute to the pre-therapeutic assessment of the biologic aggressiveness of the disease and to detect malignant potential of premalignant lesion and conditions which could render us to assess the prognosis of the disease.

  11. Systemic treatment of lichen planus and Experience%浅析扁平苔藓的全身治疗方法与体会

    Institute of Scientific and Technical Information of China (English)

    刁宁

    2015-01-01

    Objective To investigate the systemic treatment of lichen planus and experience .Methods November 2013 - May 2014 in our hospital 42 cases of patients with lichen planus data analysis . Results42 patients after treatment achieved better results.Conclusion :Lichen planus is chronic , its longer duration, easily repeated , the election of a suitable method can reduce patient pain.%目的:探讨扁平苔藓的全身治疗方法与体会。方法:对2013年11月—2014年5月我院收治的42例扁平苔藓患者进行资料分析。结果:治疗后的42例患者均取得较好的疗效。结论:扁平苔藓为慢性病,其病程长、易反复,选对合适的方法可减轻患者痛楚。

  12. A comparative study of toluidine blue-mediated photodynamic therapy versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus: a randomized clinical controlled trial.

    Science.gov (United States)

    Jajarm, Hasan Hoseinpour; Falaki, Farnaz; Sanatkhani, Majid; Ahmadzadeh, Meysam; Ahrari, Farzaneh; Shafaee, Hooman

    2015-07-01

    Recently, photodynamic therapy (PDT) has been suggested as a new treatment option that is free from side effects for erosive-atrophic oral lichen planus (OLP). The purpose of this study was to compare the effect of toluidine blue-mediated photodynamic therapy (TB-PDT) with local corticosteroids on treatment of erosive-atrophic OLP. In this randomized clinical trial, 25 patients with keratotic-atrophic-erosive oral lichen planus were allocated randomly into two groups. Group 1 (experimental): topical application of toluidine blue with micropipette was applied, and after 10 min, the patients were treated with a 630-nm GaAlAs laser (power density: 10 mW/cm(2)) during two visits. Group 2 (control) used mouthwash diluted with dexamethasone (tab 0/5 in 5 ml water) for 5 min, and then, it was spat out, and after 30 min, the mouth was rinsed with 30 drops of nystatin 100,000 units for 5 min and again spat out. Demographic data, type, and severity of the lesions and pain were recorded before and after treatment and then at the 1-month follow-up visit. Response rate was defined based on changes in intensity of the lesions and pain. In the experimental and control groups, sign scores of changes significantly reduced after treatment respectively (p = 0.021) and (p = 0.002), but between the two groups, no significant difference was observed (p = 0.72). In the experimental (p = 0.005) and control groups (p = 0.001), the intensity of lesions significantly reduced after treatment and there was a significant difference between the two groups (p = 0.001). The mean amount of improvement in pain was significantly greater in the control group compared with the experimental group (p < 0.001) (α = 0.05). Our study showed that TB-PDT with laser was effective in the management of OLP.

  13. The role of interleukin-17 lichen planus%IL-17在扁平苔藓发病机制中的作用

    Institute of Scientific and Technical Information of China (English)

    高丽娟; 李俊艳; 聂振华

    2012-01-01

    目的:探讨IL-17在扁平苔藓发病机制中的作用.方法:扁乎苔藓患者应用雷公藤1mg/ (kg·d)治疗,分别用ELISA法检测患者治疗前后及正常对照组外周血IL-17水平.结果:扁平苔藓组外周血IL-17的水平(16.6±4.5) ng/L明显高于正常对照组(7.7±2.8) ng/L,两组比较差异有统计学意义(P<0.05);扁平苔藓组使用雷公藤治疗后,总有效率为73%,随病情好转IL-17水平明显降低,和治疗前比较差异有统计学意义(P<0.05).结论:IL-17参与扁平苔藓的发病,其水平随着病情的缓解而相应降低,提示它可作为监测扁平苔藓病情变化及评价临床疗效的指标.%Objective: To investigate the role of IL-17 in lichen planus. Methods.- The serum IL-17 in patients with lichen planus was assessed before and after treatment of Tripterygium Wilfordii by enzyme-linked immu-nosorbent assay (ELISA), while it was also assessed in included controls. Results: The level of IL-17 in patients with lichen planus was significant higher than that in controls (16. 6 ± 4. 5 vs 7. 7 ± 2. 8, P < 0.05), and it was significantly reduced after treatment with Tripterygium Wilfordii (P <0.05). Conclusion: IL-17 is positively correlated with the course of lichen planus, providing a feasible indicator of lichen planus.

  14. Correlation of STATs family expression in oral lichen planus tissue with peripheral blood PD-1 and PD-L1 expression as well as immune function

    Institute of Scientific and Technical Information of China (English)

    Hong Zhang; Ying Zhang

    2016-01-01

    Objective:To study the correlation of STATs family expression in oral lichen planus tissue with peripheral blood PD-1 and PD-L1 expression as well as immune function.Methods:A total of 47 patients diagnosed with oral lichen planus in our hospital between May 2015 and March 2016 were selected as the oral lichen planus group (OLP group) of the study, and healthy volunteers receiving physical examination during the same period were selected as the control group of the study. Peripheral blood mononuclear cells were collected to detect the expression of PD-1, PD-L1 and immune cell surface marker molecules, serum was collected to detect the content of Th1 and Th2 cytokines as well as immunoglobulin, and oral lichen planus lesion tissue and adjacent normal tissue were collected to determine STATs family expression. Results: p-STAT1, p-STAT3 and p-STAT5a expression in lesion tissue were significantly higher than those in normal tissue while p-STAT2, p-STAT4 and p-STAT5b expression were not significantly different from those in normal tissue; PD-1 and PD-L1 mRNA expression as well as the mean fluorescence intensity of CD19+ in peripheral blood mononuclear cells of OLP group were significantly higher than those of control group and positively correlated with p-STAT1, p-STAT3 and p-STAT5a expression while the mean fluorescence intensity of CD3+, CD4+, CD8+ and CD16+CD56+ were significantly lower than those of control group and negatively correlated with p-STAT1, p-STAT3 and p-STAT5a expression; serum IFN-γ and IL-2 content of OLP group were significantly lower than those of control group and negatively correlated with p-STAT1, p-STAT3 and p-STAT5a expression while IL-4, IL-10, IgG, IgM and IgA content were significantly higher than those of control group and positively correlated with p-STAT1, p-STAT3 and p-STAT5a expression.Conclusion: p-STAT1, p-STAT3 and p-STAT5a expression abnormally increase in oral lichen planus tissues, and the Th1/Th2 cellular immunity and humoral

  15. Oral lichen planus versus epithelial dysplasia: difficulties in diagnosis Líquen plano bucal versus displasia epitelial: dificuldades diagnósticas

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    Fernando Augusto Cervantes Garcia de Sousa

    2009-10-01

    Full Text Available Histopathological diagnosis of oral lichen planus is not easy since some cases of epithelial dysplasia may present traits which are very similar to those from lichen planus. AIM: to compare cell alterations which suggest malignancy present in oral lichen planus with those from epithelial dysplasia. MATERIAL AND METHODS: histological cross-sections of oral lichen planus and dysplasia, dyed by hematoxylin-eosin, were analyzed by means of light microscopy. RESULTS: variance analysis (alpha=5% revealed a statistically significant difference between the average number of cell alterations in the lichen planus (5.83±1.61 and epithelial dysplasia (4.46±1.26. The chi-squared test did not show statistically significant differences between oral lichen planus and epithelial dysplasia in relation to the following cell alterations: increase in nucleus/cytoplasm ratio, nuclear hyperchromatism, irregular chromatin distribution and enlarged nuclei (p>0.05. CONCLUSION: Some cell alterations which suggest malignancy present in the oral lichen planus may also be found in epithelial dysplasia, impairing its diagnosis and, consequently, stressing the importance of following these patients in the long run.O diagnóstico histopatológico do líquen plano bucal não é fácil, pois alguns casos de displasia epitelial podem apresentar características bastante semelhantes às do líquen plano. OBJETIVO: Comparar as alterações celulares sugestivas de malignidade presentes no líquen plano bucal com as da displasia epitelial. MATERIAL E MÉTODOS: Cortes histológicos de líquen plano bucal e displasia, corados com hematoxilina-eosina, foram analisados por meio da microscopia de luz. RESULTADOS: A análise de variância (alfa=5% revelou haver diferença estatisticamente significante entre o número médio de alterações celulares no líquen plano bucal (5,83±1,61 e na displasia epitelial (4,46±1,26. O teste de qui-quadrado não mostrou diferença estatisticamente

  16. Apoptosis y liquen plano oral: Situación actual Apoptosis and oral lichen planus: Actual state

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    J.M. Aguado Gil

    2009-02-01

    Full Text Available El liquen plano oral (LPO es una enfermedad mucocutánea inflamatoria crónica, con una etiología aún desconocida, de base autoinmune, que suele cursar con manifestaciones orales, con una clínica e histología características y de curso evolutivo benigno, pero susceptible de transformación maligna. En los últimos años se ha investigado la relación entre su patogenia y los mecanismos apoptóticos de destrucción celular. Material y método: Búsqueda bibliográfica en el servidor de la U.S. National Library of Medicine and the National Institutes of Health (Pubmed con las palabras clave "apoptosis AND oral lichen planus". Discusión: Existen diferentes estudios que evalúan la relación de los diferentes marcadores apoptóticos (TNF-α, bcl-2, Fas, p53, BMP-4, granzima B, MMP… con la patogenia, evolución, clínica y malignización del LPO. Para la determinación de estos factores se emplean técnicas de anatomía patológica e inmunohistoquímica (TUNEL, PCR,…. Conclusión: no existe consenso en los resultados y las consiguientes conclusiones obtenidas en los diferentes estudios sobre la influencia de cada uno de los marcadores apoptóticos en el desarrollo de las lesiones de LPO. Es necesaria una mayor y más profunda investigación en búsqueda de un factor siempre asociado a las formas clínicas agresivas con mayor tendencia a la malignización.Oral lichen planus (OLP is a mucocutaneous inflammatory chronic disease, with unknown etiology, autoinmune, usually associated with characteristical oral manifestations. Despite it has a benign evolution, is posible to become malign. Lately, relation between the pathogenesis and apoptotic cells destroy has been investigated. Methods: A bibliography survey was carried out with th U.S. National Library of Medicine and the National Institutes of Health (Pubmed with the keywords "apoptosis AND oral lichen planus". Discussion: Several trials evaluate the relationship among several apoptotic

  17. Genes involved in epithelial differentiation and development are differentially expressed in oral and genital lichen planus epithelium compared to normal epithelium.

    Science.gov (United States)

    Danielsson, Karin; Coates, Philip J; Ebrahimi, Majid; Nylander, Elisabet; Wahlin, Ylva Britt; Nylander, Karin

    2014-09-01

    Lichen planus (LP) is a chronic mucocutaneous disease with unknown cause. Patients with LP often have both oral and genital lesions, but these conditions are often considered as separate diseases and treated accordingly. To find out which genes are differently expressed in mucosal LP compared to normal mucosa and establish whether oral and genital LP are in fact the same disease, whole genome expression analysis was performed on epithelium from 13 patients diagnosed with oral and/or genital LP and normal controls. For confirmation of keratin 4 and corneodesmosin expression, quantitative reverse-transcription PCR and immunohistochemistry were used. Many genes involved in epithelial development and differentiation are differently expressed in epithelium from LP compared to normal epithelium. Several of the differentially expressed genes are common for oral and genital LP and the same biological processes are altered which supports the fact that oral and genital LP are manifestations of the same disease. The change in gene expression indicates that differentiation is altered leading to changes in the epithelial barrier.

  18. A Case of Lichen Amyloidosis Treated with Low Dose Acitretin

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    Fatma Pelin Cengiz

    2014-12-01

    Full Text Available Primary localized cutaneous amyloidosis (PCA is a rare disorder characterized by amyloid deposition in dermis without systemic involvement. There are three different types of primary localized cutaneous amyloidosis: Lichen amyloidosis, macular amyloidosis and nodular amyloidosis. The lesions of lichen amyloidosis are characterized by pruritic papules. Although, topical or intralesional treatment with corticosteroids, topical dimethyl sulfoxide, ultraviolet B, oral psoralen plus ultraviolet A, retinoic acid derivatives are the recommended treatment for lichen amyloidosis, the results are often unsatisfactory. In the literature, there have been only a few reports evaluating the efficacy of low dose acitretin in the treatment of lichen amiloidosis. In this article, we report a case of lichen amyloidosis with pruritic hyperkeratotic papules on the back and chest of 5 years’ duration, successfully treated with low dose acitretin.

  19. The Effect of Pimecrolimus Cream 1% Compared with Triamcinolone Acetonide Paste in Treatment of Atrophic-Erosive Oral Lichen Planus

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    Atessa Pakfetrat

    2015-03-01

    Full Text Available Introduction: Oral lichen planus (OLP is a common chronic mucocutaneous disease. Patients with atrophic and erosive types of OLP often have symptoms of soreness, and require proper treatment. The main treatment for OLP has been the administration of topical or systemic corticosteroids. The objective of this study was to compare the efficacy of adcortyl cream (triamcinolone acetonide in orabase with topical pimecrolimus cream for the treatment of erosive OLP.   Materials and Methods: Twenty-eight patients with OLP were enrolled in a single blind clinical trial and assigned to either a pimecrolimus 1% cream group or an adcortyl 0.1% cream group. The medication was applied every day for 2 months and patients were assessed every 2 weeks.   Results: The mean lesion size and mean pain and burning sensation scores did not differ between the pimecrolimus and adcortyl cream groups. The pimecrolimus cream was well tolerated. No clinical drug-related adverse events were observed.   Conclusion:  Topical pimecrolimus cream may be recommended as a safe and effective alternative therapy in the treatment of OLP. Pimecrolimus cream is as effective as adcortyl cream in managing the signs and symptoms of OLP.

  20. The Effect of Pimecrolimus Cream 1% Compared with Triamcinolone Acetonide Paste in Treatment of Atrophic-Erosive Oral Lichen Planus

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    Atessa Pakfetrat

    2015-03-01

    Full Text Available Introduction: Oral lichen planus (OLP is a common chronic mucocutaneous disease. Patients with atrophic and erosive types of OLP often have symptoms of soreness, and require proper treatment. The main treatment for OLP has been the administration of topical or systemic corticosteroids. The objective of this study was to compare the efficacy of adcortyl cream (triamcinolone acetonide in orabase with topical pimecrolimus cream for the treatment of erosive OLP.   Materials and Methods: Twenty-eight patients with OLP were enrolled in a single blind clinical trial and assigned to either a pimecrolimus 1% cream group or an adcortyl 0.1% cream group. The medication was applied every day for 2 months and patients were assessed every 2 weeks.   Results: The mean lesion size and mean pain and burning sensation scores did not differ between the pimecrolimus and adcortyl cream groups. The pimecrolimus cream was well tolerated. No clinical drug-related adverse events were observed.   Conclusion:  Topical pimecrolimus cream may be recommended as a safe and effective alternative therapy in the treatment of OLP. Pimecrolimus cream is as effective as adcortyl cream in managing the signs and symptoms of OLP.

  1. Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial

    Science.gov (United States)

    Dillenburg, Caroline Siviero; Martins, Marco Antonio Trevizani; Munerato, Maria Cristina; Marques, Márcia Martins; Carrard, Vinícius Coelho; Filho, Manoel Sant'Ana; Castilho, Rogério Moraes; Martins, Manoela Domingues

    2014-06-01

    Oral lichen planus (OLP) is a relatively common chronic mucocutaneous inflammatory disease and a search for novel therapeutic options has been performed. We sought to compare the efficacy of laser phototherapy (LPT) to topical clobetasol propionate 0.05% for the treatment of atrophic and erosive OLP. Forty-two patients with atrophic/erosive OLP were randomly allocated to two groups: clobetasol group (n=21): application of topical clobetasol propionate gel (0.05%) three times a day; LPT group (n=21): application of laser irradiation using InGaAlP diode laser three times a week. Evaluations were performed once a week during treatment (Days 7, 14, 21, and 30) and in four weeks (Day 60) and eight weeks (Day 90) after treatment. At the end of treatment (Day 30), significant reductions in all variables were found in both groups. The LPT group had a higher percentage of complete lesion resolution. At follow-up periods (Days 60 and 90), the LPT group maintained the clinical pattern seen at Day 30, with no recurrence of the lesions, whereas the clobetasol group exhibited worsening for all variables analyzed. These findings suggest that the LPT proved more effective than topical clobetasol 0.05% for the treatment of OLP.

  2. Prevalence of hepatitis C and hepatitis B virus infection(s in patients with oral lichen planus

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    Perumal Jayavelu

    2012-01-01

    Full Text Available Aim: The aim of this study was to determine the prevalence of hepatitis B virus and hepatitis C virus (HCV infections in patients with oral lichen planus (OLP and to compare it with that of general population. Materials and Methods: A total of 60 patients were included in the study. Patients were selected from the outpatient department of Rama Dental College Research Centre, Kanpur, Uttar Pradesh. Thirty patients with OLP were included in Group 1. Thirty age- and sex-matched healthy patients with no history of oral or skin lesions were included in Group 2. Detailed case history, biopsy (the most representative site of the lesion is chosen for specimen, detection of hepatitis B surface antigen (HBsAg, and detection of anti-HCV antibody were carried out. Results: The serum of the entire study sample (Group 1 and Group 2 was tested for both hepatitis C antibodies and HBsAgs with the enzyme-linked immunosorbent assay (ELISA test (using the third generation kit. It was found negative for both HBsAgs and hepatitis C antibodies. Conclusion: In the present study, all the samples including OLP patients and healthy patients were seronegative for both hepatitis B (HBsAg and hepatitis C (HCV antibody.

  3. MUC1 and Toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus.

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    Kho, Hong-Seop; Chang, Ji-Youn; Kim, Yoon-Young; Kim, Yongdae

    2013-07-01

    Expression levels of MUC1 and TLR-2 were evaluated in burning mouth syndrome (BMS) patients and compared with those of controls and oral lichen planus (OLP) patients. The relationships between the expression levels of MUC1 and TLR-2 and levels of salivary pro-inflammatory cytokines were also investigated. Ten female BMS and ten female OLP patients were included. Ten female age-matched volunteers served as controls. RNA was isolated from stimulated whole saliva samples. Real-time PCR was used to quantify MUC1 and TLR-2 mRNA levels relative to β-actin and GAPDH mRNA levels. The clarified supernatants of saliva samples were used to measure IL-1β, IL-6, IL-8, and TNF-α levels. The level of blood contamination in saliva samples was also determined. There were significant increases in MUC1 transcripts in BMS patients compared with OLP patients (1.766-fold) as well as controls (1.840-fold). There was no significant difference in TLR-2 expression among the groups. The OLP patients showed significantly higher levels of IL-6 and blood contamination in saliva than other groups. The levels of MUC1 or TLR-2 expression did not correlate significantly with the levels of cytokines or blood contamination in saliva. MUC1 may play a role in the development and/or progression of BMS. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus

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    Wen-Zhao Liu; Qian-Ming Chen; Ming-Jing He; Long Long; Dong-Liang Mu; Ming-Shu Xu; Xue Xing; Xin Zeng; Ga Liao; Hong-Xia Dan

    2014-01-01

    Our previous salivary study had demonstrated an apparent T helper 2 (Th2)-predominance in saliva of oral lichen planus (OLP) patients and suggested a potential of salivary interleukin-4 (IL-4) as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-c (IFN-c) and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP (40 of the erythematous/ulcerative form and 20 of the reticular form) were recruited for this study, with 40 age-sex-matched healthy volunteers as control group. IFN-c and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-c but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-c/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-c and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokine-predominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP.

  5. Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients

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    Milad ALIKHANI

    Full Text Available Abstract This study considered a possible relationship between the severity of oral lichen planus (OLP, serum anti-TPO autoantibodies (TPOAb titer and thyroid disease in OLP patients. Forty-six OLP patients with positive TPOAb results (> 35 IU/ml who had also been diagnosed with thyroid disease were included in the study group. The control group consisted of 46OLP patients with no thyroid disease. The study and control groups (92 were divided to two subgroups of erosive OLP (EOLP and non-erosive OLP (NEOLP. Serum TPOAb levels and IL-8 (to measure OLP severity were evaluated using the independent t-test, chi-square and conditional logistic regression analysis (α = 0.05. A significant positive correlation was found between serum IL-8 and TPOAb levels in the study group (r = 0.783; p = 0.001. The positive blood levels of TPOAb were significantly associated with an increased risk of EOLP (OR = 4.02 at 95%CI; 1.21–13.4; p = 0.023. It is possible to used positive serum TPOAb levels in patients with OLP as in indicator of possible undetected thyroid disorders in those patients. Because erosive OLP has been associated with TPOAb in thyroid patients, it may be useful to determine TPOAb levels of such patients to diagnose a possible undetected thyroid disorders and follow-up for malignancy.

  6. Analysis of oral microbial community and Th17-associated cytokines in saliva of patients with oral lichen planus.

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    Wang, Kun; Miao, Tianyu; Lu, Wenxin; He, Jinzhi; Cui, Bomiao; Li, Jiyao; Li, Yan; Xiao, Liying

    2015-03-01

    Oral lichen planus (OLP) is a chronic inflammatory disorder of oral mucosa of unknown cause. Microbial infection and dysimmunity appear to play important roles in its pathogenesis. In this study, differences in genetic profiling of salivary microbial communities in two subtypes of OLP and healthy controls were evaluated by means of PCR-denaturing gradient gel electrophoresis (DGGE). Additionally, ELISA was used to investigate the possible role of Th17 in lesion formation by detecting two related cytokines IL-17 and IL-23 in the saliva of OLP patients. When the DGGE profiles were analyzed, the bacterial populations were found to be significantly less rich in subjects with reticular and erosive OLP than in healthy controls. There was significantly less microbial diversity, as denoted by the Shannon index, in saliva samples from subjects with erosive OLP than in those from healthy controls. Cluster analysis and principal component analysis showed that the DGGE profiles formed distinctly group-specific clusters. Salivary concentrations of IL-17 in subjects with erosive OLP group were significantly higher than in those with reticular OLP and healthy controls. What's more, significantly positive correlations were observed between salivary IL-17 concentrations and disease clinical scores. Microbial richness and diversity was negatively correlated with salivary IL-17 concentrations. These results suggest there is significantly less salivary bacterial diversity and complexity in subjects with OLP han in healthy controls and that the shifted community composition is closely related to an immune cytokine, IL-17.

  7. The effect of pimecrolimus cream 1% compared with triamcinolone acetonide paste in treatment of atrophic-erosive oral lichen planus.

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    Pakfetrat, Atessa; Delavarian, Zahra; Falaki, Farnaz; Khorashadizadeh, Mahboubeh; Saba, Mina

    2015-03-01

    Oral lichen planus (OLP) is a common chronic mucocutaneous disease. Patients with atrophic and erosive types of OLP often have symptoms of soreness, and require proper treatment. The main treatment for OLP has been the administration of topical or systemic corticosteroids. The objective of this study was to compare the efficacy of adcortyl cream (triamcinolone acetonide in orabase) with topical pimecrolimus cream for the treatment of erosive OLP. Twenty-eight patients with OLP were enrolled in a single blind clinical trial and assigned to either a pimecrolimus 1% cream group or an adcortyl 0.1% cream group. The medication was applied every day for 2 months and patients were assessed every 2 weeks. The mean lesion size and mean pain and burning sensation scores did not differ between the pimecrolimus and adcortyl cream groups. The pimecrolimus cream was well tolerated. No clinical drug-related adverse events were observed. Topical pimecrolimus cream may be recommended as a safe and effective alternative therapy in the treatment of OLP. Pimecrolimus cream is as effective as adcortyl cream in managing the signs and symptoms of OLP.

  8. A Randomized Placebo-controlled Double Blind Clinical Trial of Quercetin for Treatment of Oral Lichen Planus

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    Maryam Amirchaghmaghi

    2015-03-01

    Full Text Available Background and aims. Standard treatment of oral lichen planus (OLP includes topical or systemic corticosteroids that have many adverse effects. A trend toward alternative natural or herbal drugs has attended recently. This study was con-ducted to evaluate the effect of quercetin in treatment of erosive-atrophic OLP. Materials and methods. Thirty patients participated in this randomized clinical trial from April 2010 to June 2010 (Trial Registration Number: NCT01375101. Patients were randomly allocated in two groups. Both groups received the standard treatment (dexamethasone mouthwash and nystatin suspension. Experimental group received oral 250 mg quercetin hydrate capsules (bid and the control group received placebo capsules. The pain and severity of the lesions were recorded at the initial visit and the follow-ups. All recorded data were analyzed with chi-square, Mann-Whitney, t-test, Wilcoxon and Friedman tests using SPSS 11.5. Results. There were no significant differences between the two groups in severity of the lesions and pain in the follow-ups.According to the Friedman test, there was a significant reduction in pain (P = 0.01 and severity indices (P = 0.00 in the case group. These differences were not observed in the control group (P = 0.26, SI; and P = 0.86, PI. No adverse effect of quercetin was reported. Conclusion. According to the results, no significant therapeutic effect can be considered for quercetin in treatment of OLP.

  9. Tratamiento del liquen plano oral: una revisión Treatment of oral lichen planus: a review

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    M.J. García-Pola Vallejo

    2008-02-01

    Full Text Available El objetivo del presente estudio fue realizar una revisión sobre los actuales tratamientos del liquen plano oral (LPO. Antes de iniciar el tratamiento al paciente, debe de realizarse una biopsia para establecer el correcto diagnóstico. Dado que para el LPO no hay tratamiento curativo, el primer objetivo en los pacientes sintomáticos es el efecto paliativo. Entre las alternativas terapéuticas se incluyen: corticosteroides tópicos, sistémicos e intralesionales; retinoides tópicos o sistémicos; ciclosporina tópica, tacrolimus tópico, azatioprina, fototerapia y tratamiento quirúrgico.The aim of the present study was to review about the current treatment of oral lichen planus (OLP. Before a patients is started on therapy a biopsy must be done to establish an accurate diagnosis. Because there is no curative therapy for OLP, the primary goal for symtomatic patients is palliative. Treatment modalities include the use of: topical, systemic and intralesional corticosteroids; topical and systemic retinoids, topical cyclosoporine; topical tacrolimus; azathioprine; phototherapy and surgical procedures.

  10. Evaluation of ploidy status using DNA-image cytometry of exfoliated mucosal cells in oral lichen planus

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    Ravi Teja Chitturi

    2014-01-01

    Full Text Available Background: Oral lichen planus (OLP is one of the potentially malignant disorders (PMDs with a malignancy rate of 0.2-2%. Aneuploidy is considered to be one of the important markers for malignant transformation and DNA-image cytometry (DIC has been successfully employed in oral mucosal PMDs and also in tumors of the cervix, lung and biliary tract. Aims: In this study, we intend to assess the ploidy status of exfoliated cells in OLP using DIC. Materials and Methods: Exfoliated cells from 48 patients with different subtypes of OLP (reticular, plaque type, erosive and atrophic and 10 controls were stained using Feulgen reaction and assessed for integrated optical density using image analysis software and the ploidy status was assessed. Results: All the patients in the control group and most of the patients (93.5% who had reticular or plaque type of OLP (29 out of 31 exhibited diploid nuclei in the smears, whereas 11 patients who had erosive or atrophic types of OLP showed aneuploid nuclei. Conclusions: The patients with erosive or atrophic types of OLP are at more risk and assessment of ploidy status by exfoliative cytology can be used as an adjuvant for diagnosis.

  11. Concept actuel du lichen plan oral. Le diagnostic facile au début, peut devenir très difficile dans les lichens anciens

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    Lombardi, Tommaso; Kuffer, Roger

    2016-01-01

    Dynamic concept of oral lichen planus. The diagnosis easy at early stages may become difficult in ancient lichen planus. Lichen planus is a chronic inflammatory dermatosis of the skin, skin appendages and mucous membranes, which frequently affects the oral mucosa. Its aetiology still remains unknown, and currently accepted pathogenesis is that of an autoimmune cell-mediated disease. To the contrary of skin lichen planus, oral lichen planus is a long-term chronic disease with dynamic evolution...

  12. LIKEN PLANUS

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    Herman Cipto

    2015-01-01

    Lichen planus (LP) is an inflammation skin and mucous membrane disease that has characteristic clinical and pathologic features. Typical lesion of LP are small, flat-topped, polygonal, violaceous papules on the skin or reticular, white patch or plaque on mucous membrane. Nail involvement is manifested by longitudinal ridging, thinning and distal splitting and hair involvement is atrophic cicatrical alopesia. There was an increased risk of developing squamous cell carcinoma in the leasion of m...

  13. Líquen plano hipertrófico disseminado: relevante resposta à acitretina Disseminated hypertrophic lichen planus: relevant response to acitretin

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    Thais Jerez Jaime

    2011-08-01

    Full Text Available O líquen plano hipertrófico é uma variante do líquen plano, com pronunciada hiperplasia epidérmica em resposta à coçadura persistente. Clinicamente, caracterizam-se por placas hiperceratósicas, simétricas, de coloração cinza-violácea, com predileção pela região pré-tibial. O prurido intenso, a refratariedade aos tratamentos convencionais e a possibilidade de associação de um carcinoma epidermoide às lesões de longa duração impõem um tratamento eficaz. Os corticoides são considerados o tratamento de primeira linha e podem ser aplicados topicamente ou empregados de forma sistêmica. Outras modalidades terapêuticas propostas são a fototerapia com UVB-NB ou PUVA, imunossupressores e retinoides sistêmicos, com destaque para a acitretina. Relatamos um caso com apresentação clínica exuberante e excelente resposta à acitretin, totalizando um seguimento de nove mesesHyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness to conventional treatments and the possibility of association of the long-term injuries with squamous cell carcinoma requires an effective treatment. The first-line treatment is corticosteroids which can be applied either topically or systemically. Other therapeutic modalities proposed are: NB-UVB phototherapy or PUVA, immunosuppressive drugs and systemic retinoids, notably acitretin. We report a case with exuberant clinical presentation of hyperthrofic lichen planus with excellent response to acitretin after nine months of treatment

  14. Líquen plano bucal: considerações clínicas e histopatológicas Oral lichen planus: clinical and histopathological considerations

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    Fernando Augusto Cervantes Garcia de Sousa

    2008-04-01

    Full Text Available O líquen plano é uma das doenças dermatológicas mais comuns que acometem a cavidade bucal, com prevalência de 1% a 2% na população geral. Contudo, apesar de relativamente freqüente, o líquen plano bucal é alvo de muita controvérsia, especialmente em relação ao seu potencial de malignização. OBJETIVO: O presente trabalho tem como objetivo tecer considerações clínicas e histopatológicas a respeito do líquen plano bucal, favorecendo seu entendimento por parte dos profissionais da saúde e, conseqüentemente, reforçando a importância do acompanhamento a longo prazo dos pacientes acometidos pela doença. CONCLUSÃO: A possibilidade da lesão sofrer transformação maligna justifica a importância do acompanhamento a longo prazo dos pacientes com a doença.Oral lichen planus is one of the most common dermatological diseases presenting in the oral cavity; the prevalence in the general population is 1% to 2%. Although relatively frequent, oral lichen planus is the target of much controversy, especially in relation to its potential for malignancy. AIM: This study aimed to make clinical and histopathological considerations regarding oral lichen planus to increase the level of knowledge about this condition among health professionals, underlining the importance of long-term follow-up of these patients. CONCLUSION: The possibility of this lesion to turn malignant justifies the importance of long term follow up for patients with such disease.

  15. p53与口腔扁平苔藓相关性的Meta分析%Meta analysis of the relevance between p53 and oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    董红; 邓志鹏

    2013-01-01

    目的 探讨p53蛋白在口腔扁平苔藓(Oral lichen planus,OLP)病变组织中的表达及意义.方法 采用计算机检索Pubmed、Cochrane图书馆和Embase外文数据库及CBM等中文数据库p53与OLP相关的单中心研究文献,采用Revman5.0软件分析p53与OLP的相关性,计算OR值和95% CI.结果 最终纳入相关性研究文献9篇,其中病例组(Oral lichen planus,OLP) 271例,对照组(Normal oral mucosa,NOM) 105例,OLP病变组织p53阳性率是NOM的4.62倍(95%CI=2.00~10.64),合并值Z=3.59,P<0.001,说明p53在OLP组与在NOM组的阳性表达差异有统计学意义.结论 p53的表达与OLP的发生、发展存在密切相关性,可将其作为预测OLP恶变潜能的生物学标志物.%Objective To investigate the expression of p53 protein in oral lichen planus (OLP) lesion formation and its significance. Methods The Pubmed, Cochrane Library, Embase database and CBM were searched for papers regarding p53 and OLP. Revman5.0 software was adopted to analyze the correlation of p53 and OLP by calculating OR and 95% CI. Results Nine papers were studied and analyzed, involving 271 cases in the study group (oral lichen planus, OLP group) and 105 cases in the control group (normal oral mucosa, NOM group). The p53 positive rate of the OLP group was 4.62 times as that of the NOM group (95% CI=2.00~10.64), merge Z value=3.59, P<0.001), showing statistically significant difference in p53 positive rate between the two groups. Conclusion The expression of p53 is correlated with the occurrence of OLP.

  16. Evaluation of the System in the Treatment of Oral Lichen Planus%口腔扁平苔藓治疗的系统评价

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    李欣

    2015-01-01

    Objective To finish on the clinical data of patients with oral lichen planus,summarize the clinical experience.MethodsA total of 86 cases of oral lichen planus patients in our hospital from 2014 January to 2014 December were analyzed,and randomly divided into experimental group and control group,each group had 43 patients. Treatment of patients in the experimental group used glucocorticoid for oral lichen planus,while the control group used the danshentong capsules and dahuang zhechong pil treatment. In 1 months for a course of treatment,compared two groups of patients after the treatment curative efect.Results In the treatment of patients in the experimental group the total efective rate was 93%,control group patients in the treatment group the total eficiency was 81.3%. Treatment of patients in the experimental group the efective rate was significantly higher than the control group,the efective rate of treatment in two groups had obvious diference was statisticaly significant(P< 0.05).Conclusion Glucocorticoid has obvious therapeutic efect in the treatment of oral lichen planus.%目的:整理口腔扁平苔藓患者治疗的临床资料,总结临床经验。方法选取我院2014年1~12月收治的86例口腔扁平苔藓患者,将其随机分为实验组和对照组,每组各43例患者。实验组患者使用糖皮质激素进行口腔扁平苔藓的治疗,对照组使用丹参酮胶囊和大黄蛰虫丸进行治疗。以1个月为一个疗程,比较两组患者治疗后的治疗效果。结果实验组患者的治疗总有效率达93%,对照组患者的治疗总有效率为81.3%。实验组患者的治疗有效率高于对照组,两组患者的治疗有效率差异具有统计学意义(P<0.05)。结论糖皮质激素在治疗口腔扁平苔藓治疗效果明显。

  17. 口腔扁平苔藓与系统性疾病的关系%Relationship between oral lichen planus and systemic diseases

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    周婷婷; 华红

    2015-01-01

    口腔扁平苔藓(oral lichen planus,OLP)是一种慢性炎症性皮肤黏膜病,病因复杂,确切病因目前尚不清楚.随着研究的进展,越来越多的研究发现,OLP与高血压、糖尿病、慢性肝病以及甲状腺疾病等一些系统性疾病关系密切.现结合国内外文献就此方面内容做一论述.

  18. Interrelationship of dendritic cells, type 1 interferon system, regulatory T cells and toll-like receptors and their role in lichen planus and lupus erythematosus -- a literature review.

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    Trucci, Victoria Martina; Salum, Fernanda Gonçalves; Figueiredo, Maria Antonia; Cherubini, Karen

    2013-10-01

    There is evidence that the activation of some receptors of the toll-like family (TLRs) of the innate immune system, and also changes in expression levels of forkhead box p3 (Foxp3) protein, which is found in regulatory T cells (Tregs), could be involved in the development of autoimmunity. We present here a literature review focusing on the interrelationship of dendritic cells, TLRs, Tregs and type 1 interferon in autoimmune diseases, with special interest in lichen planus and lupus erythematosus. Understanding the specific role of each of these factors would help elucidate the obscure aetiology of such diseases and open new perspectives for their management and treatment.

  19. 他克莫司软膏治疗口腔扁平苔藓的临床分析%Clinical Study on Tacrolimus Ointment in Treatment of Oral Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    李桂香

    2015-01-01

    目的:探究口腔扁平苔藓患者采用他克莫司软膏治疗的方法和效果。方法选取2013年3月~2014年9月收治的35例口腔扁平苔藓患者进行治疗,随机分组,实验组18例患者选择他克莫司软膏的治疗,对照组17例患者选择患者卤米松乳膏的使用,观察治疗后的改善情况。结果实验组治疗有效率为94.44%,对照组治疗有效率为82.35%,差异显著,且两组患者不良反应率也有较大差异(P均<0.05)。%Objective To explore treatment method and its effect of Tacrolimus ointment in treatment of oral lichen planus. MethodsChoose 35 patients of oral lichen planus who are treated in hospital from March 2013 to September 2014 and separate them into two groups at random, 18 patients in study group are given Tacrolimus ointment treatment, while 17 patients in control group are given Halometasone ointment treatment, and then make a comparative study on patients’ recovery between two groups. ResultsPatients’ treatment efifcacy in study group is up to 94.44%, while patients’ treatment efifcacy in control group is up to 82.35%; there is a great differential between two groups in terms of treatment efifcacy as well as side-effect incidence and such a differential has statistic value(P<0.05). Conclusion Tacrolimus ointment is of efifcacy in treatment of oral lichen planus; it is conducive to relieving patients’ pain in short time without any side effect; and such a treatment method is quite safe and efifciency, therefore, it is worthwhile to be promoted widespread.

  20. Actinic lichen nitidus

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    Loretta Davis

    2010-01-01

    Full Text Available We present the case of a 29-year-old black female with an initial clinical and histopathologic diagnosis of actinic lichen nitidus. Three years later, she presented with scattered hyperpigmented macules with oval pink/viol­aceous plaques bilaterally on her forearms and on her neck, clinically consistent with actinic lichen planus. She was treated with topical steroids at each visit, with subsequent resolution of her lesions. In this report, we discuss the spectrum of actinic lichenoid dermatoses and of disease that presents even in the same patient.

  1. The oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus

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    Arzu Kılıç

    2015-12-01

    Full Text Available Background and Design: Various reports have demonstrated an association between inflammatory skin disorders and oxidative stress. Additionally, dyslipidemia and systemic disorders have been found to associate with chronic inflammatory skin diseases. In this study, we aimed to investigate the oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus (LP. Materials and Methods: Fifty-four patients with LP and 60 control subjects were enrolled in the study. Total cholesterol, triglyceride, highdensity lipoprotein cholesterol (HDL-C, low-de nsity lipoprotein cholesterol (LDL-C, and very low density lipoprotein cholesterol (VLDL-C levels were studied in all participants. After participants with associated systemic diseases were excluded, total antioxidant status (TAS, paraoxonase (PON, arylesterease, stimulated PON and total thiol levels (TTL levels were studied in 36 patients with LP and control group. Results: 62.96% of the patients were detected to have dyslipidemia. Total cholesterol and LDL-C levels were found to be significantly higher and HDL-C levels were found to be significantly lower in patient group when compared with control group. Serum TAS was found to be significantly lower in patient group than in control group. When patients with dyslipidemia were compared with patients without dyslipidemia in terms of oxidative stress parameters, serum level of TTL was found to be lower in patients with dyslipidemia. Conclusion: In this study, LP was associated with dyslipidemia. Besides, our findings showed that decreased TAS activity might have a role in the pathogenesis of LP. Our findings support that associated dyslipidemia may contribute to the etiopathogenesis of LP by reducing the antioxidant defense. Prospective studies with larger samples are needed to enlighten the possible effects of dyslipidemia on the incidence, mechanism and severity of LP

  2. Effect of oral care gel on the quality of life for oral lichen planus in patients with chronic HCV infection

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    Sata Michio

    2011-07-01

    Full Text Available Abstract Background Oral lichen planus (OLP decreases the quality of life because it can cause spontaneous pain during eating and tooth-brushing and an uncomfortable feeling in the mouth. In addition, OLP may be associated with HCV-related liver disease. We investigated the visual analogue scale (VAS and effects of oral care gel, REFRECARE-H®, on patients with OLP associated with HCV infection. Results Nine OLP patients (mean age 67.9 ± 7.6 years with HCV-related liver diseases were recruited and their VAS score determined along with a biochemical examination of the blood. Types of OLP included erosive (6 patients and reticular (3. REFRECARE-H®, an oral care gel (therapeutic dentifrice containing hinokitiol, was applied by each patient as a thin layer on the oral membrane, after each meal and at bedtime for 30 days. Application of REFRECARE-H® improved the quality of life in all terms of dry mouth, breath odor, oral freshness, oral pain during rest, oral pain at a mealtimes, taste disorder, loss of appetite, sleep disorder, depressive mood and jitteriness. VAS scores of dry mouth, breath odor, oral freshness, and sleep disorder were significantly increased 30 days after application of REFRECARE-H® (P = 0.01, P = 0.05, P = 0.03, P = 0.04. VAS scores of oral pain at a mealtimes and taste disorder were increased 30 days after application of REFRECARE-H® (P = 0.06. There was an absence of side effects. Conclusions REFRECARE-H® improved the quality of life for OLP. It is necessary for the hepatologist to educate patients regarding oral hygiene, as well as provide treatment of liver disease.

  3. LIKEN PLANUS

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    Herman Cipto

    2015-08-01

    Full Text Available Lichen planus (LP is an inflammation skin and mucous membrane disease that has characteristic clinical and pathologic features. Typical lesion of LP are small, flat-topped, polygonal, violaceous papules on the skin or reticular, white patch or plaque on mucous membrane. Nail involvement is manifested by longitudinal ridging, thinning and distal splitting and hair involvement is atrophic cicatrical alopesia. There was an increased risk of developing squamous cell carcinoma in the leasion of mucous membrane of oral cavity. Pathology of LP is the prototype of lichenoid interface dermatitis, which shows damage to the basal cell layer and a band-like dental lymphocytic infiltrate in close approximation to the epidermis. Other pathologic findings are compact orthokeratosis, wedge-shape hypergranulosis and irregular acanthosis. The treatment of LP in the main is largely symptomatic like antipruritic for itching. Therapies to suppress immune responses are commonly effective in treating LP, such as corticosteroid and cyclosporine topical or systemic. Other treatment are psoralene ultra violet A (PUVA or steroids.

  4. Líquen plano oral (LPO: diagnóstico clínico e complementar Oral lichen planus (OLP: clinical and complementary diagnosis

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    Alan Motta do Canto

    2010-10-01

    Full Text Available O líquen plano é uma desordem comum do epitélio escamoso estratificado que acomete as mucosas oral e genital, a pele, as unhas e o couro cabeludo. O líquen plano oral (LPO afeta mulheres de meiaidade e apresenta padrões e distribuição característicos, como estriações brancas, pápulas ou placas brancas, eritema, erosões e bolhas, que podem estar associadas a medicações e/ou materiais dentários no paciente. O diagnóstico clínico somente poderá ser feito se a doença apresentar padrões clássicos, como lesões concomitantes na mucosa oral e na pele. O diagnóstico laboratorial por meio do exame histopatológico se caracteriza pela presença de projeções do epitélio em forma de dentes de serra e corpos de Civatte, e possibilita excluir condições de displasia e malignidade. A imunofluorescência direta é utilizada em suspeita de outras doenças, como pênfigo e penfigoide. O LPO é tratado com agentes anti-inflamatórios, principalmente, corticosteroides tópicos, e novos agentes e técnicas têm-se demonstrado eficazes. A transformação maligna do LPO e sua incidência exata permanecem controversas. Este trabalho tem como objetivo apresentar, com base na revisão da literatura, a etiopatogenia, o diagnóstico clínico, exames complementares e complicações do LPO.Lichen planus is a common disorder of the stratified squamous epithelium that affects oral and genital mucous membranes, skin, nails, and scalp. Oral Lichen Planus (OLP affects middle-aged women and shows distribution patterns and characteristics such as white striations, white plaques or papules, erythema, blisters and erosions, and may be associated with medication and/or dental materials used by the patient. The clinical diagnosis can only be made if the disease presents classical patterns such as concomitant lesions in the oral mucosa and skin. The laboratory diagnosis is histopathologically characterized by the presence of projections of the epithelium in the

  5. Update of the Caspase-3 and Caspase-8 in lichen planus%Caspase-3和 Caspase-8与扁平苔藓的研究进展

    Institute of Scientific and Technical Information of China (English)

    李帅; 栗玉珍

    2016-01-01

    Caspase-3 and Caspase-8 are important proteins in the process of apoptosis. Caspase-8 can start apoptotic reaction which can mediate apoptosis in a variety of ways. Caspase-3 can accelerate cell apop-tosis after activation. The new studies reported high expression of Caspase-3, Caspase-8 in lichen planus le-sions, especially in the basal layer which showed that Caspase-3, Caspase-8 might be involved in the apop-totic response process of lichen planus.%Caspase-3和 Caspase-8作为含半胱氨酸的天冬氨酸蛋白水解酶家族成员,是参与细胞凋亡过程的两个重要蛋白。 Caspase-8是重要的凋亡启动蛋白,可通过多种途径介导凋亡反应的发生, Caspase-3作为凋亡过程中的执行者,活化后可以加速细胞凋亡的发生。最新研究发现 Caspase-3和Caspase-8在扁平苔藓皮损处(特别是基底层处)高表达,表明两者可能参与了扁平苔藓的凋亡过程,并导致了本病的病理变化。

  6. 口腔扁平苔藓患者心理状况调查及分析%A Study of the investigation of Psycho-social factors on oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    余红兵; 潘玉霞; 陈思韩; 张婷

    2015-01-01

    Objective:The aim of this study is to investigate the effects of patients′psychological background on the Oral Lichen Planus(OLP). Method:We used a control study for the 31 patients with Oral Lichen Planus,34 the normal.The patients suffering from Oral Lichen Planus were examined using Minnesota Multiphasic Personality Inventory(MMPI),Symp-tom Check List-90 (SCL-90),Social Support Scale (SS). Result:1.Compared with the normal,patients with Oral Lichen Planus had certain personality bias,and had statistically significantly higher scores in scale Hs. D. Hy. of MMPI. 2.The men-tal health status of patients worse than normal group.They had higher scores in scale Somatization,Anxiety,Depression,Psy-chotic factors,Total scores,General symptomatic Index,Additional items,and Negative、Positive symptom level of SCL-90. 3. Patients with Oral Lichen Planus had lower scores in scale Total social support and Subject social support of SS. Conclu-sion:Personality traits, mental health state,Social support are important factors associated with Oral Lichen Planus.%目的:探讨心理社会因素对口腔扁平苔藓(OLP)患者的影响. 方法:OLP 31例为研究组,健康志愿者34例为正常对照组,采用病例-对照研究,用明尼苏达人格调查表(MMPI)、社会支持评定量表(SS)及症状自评量表(SCL-90)的方法进行调查分析.结果:①.OLP患者有一定的人格偏倚,其中Hs(疑病)、D(抑郁)、Hy(瘾症)3个量表得分明显高于正常对照组. ②.OLP患者的心理健康状况差于正常组,主要表现在:躯体化、抑郁、焦虑、精神病性、总分、总均分、附加因子、阴、阳性项目数分高于正常组.③.OLP患者有较低的社会支持总分及主观支持分.结论:人格特征、心理健康状况、社会支持水平均对OLP有一定影响.

  7. Clinical Outcome of Triamcinolone Acetonide and Transfer Factor by Muscle Injection in Patients with Oral Lichen Planus%曲安奈德联合肌肉注射转移因子治疗口腔扁平苔藓的临床观察

    Institute of Scientific and Technical Information of China (English)

    郭宏; 李波; 徐贤思; 张光华; 马永清; 明朋赫

    2015-01-01

    Objective To observe the clinical effect of triamcinolone acetonide combined with intramuscular injection of transfer factor in the treatment of oral lichen planus. Methods Selection method of oral lichen planus treated a total of 58 cases,were randomly divided into two groups,the observation group using Cu Ann Ned combined with intramuscular injection of transfer factor therapy;control group only with Cu Ann Ned therapy. Results The effect of observation group is better than control group(P<0.05). The observation group the recurrence rate was significantly lower than the control group. Conclusion Significantly improve the cure rate of lichen planus triamcinolone acetonide combined with intramuscular injection of transfer factor,reduce disease recurrence.%目的:观察曲安奈德联合肌肉注射转移因子治疗扁平苔藓的临床效果。方法选择收治的口腔扁平苔藓共58例,随机分为两组,观察组采用曲安奈德联合肌肉注射转移因子治疗;对照组仅采用曲安奈德治疗。结果观察组疗效优于对照组(P<0.05)。观察组复发率明显低于对照组。结论曲安奈德联合肌肉注射转移因子可显著提高扁平苔藓的治愈率,减少病情复发。

  8. Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report

    Science.gov (United States)

    Misaka, Kenji; Kishimoto, Takashi; Kawahigashi, Yuji; Sata, Michio; Nagao, Yumiko

    2016-01-01

    Hepatitis C virus (HCV) is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA) are highly effective and safe for the eradication of HCV. However, there is a lack of information regarding the association between HCV-associated OLP and interferon (IFN)-free DAA therapy. Herein, we present the case of a 60-year-old female who was diagnosed with OLP during routine periodontal treatment by a dentist. The patient was referred for hepatitis C treatment using IFN-free DAA, which resulted in the improvement of the symptoms of OLP. This case represents the safety and efficacy of IFN-free DAAs in patients with HCV-associated OLP. However, long-term follow-up studies are required to elucidate the therapeutic effects of this therapy in these patients. PMID:27920651

  9. Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report

    Directory of Open Access Journals (Sweden)

    Kenji Misaka

    2016-10-01

    Full Text Available Hepatitis C virus (HCV is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA are highly effective and safe for the eradication of HCV. However, there is a lack of information regarding the association between HCV-associated OLP and interferon (IFN-free DAA therapy. Herein, we present the case of a 60-year-old female who was diagnosed with OLP during routine periodontal treatment by a dentist. The patient was referred for hepatitis C treatment using IFN-free DAA, which resulted in the improvement of the symptoms of OLP. This case represents the safety and efficacy of IFN-free DAAs in patients with HCV-associated OLP. However, long-term follow-up studies are required to elucidate the therapeutic effects of this therapy in these patients.

  10. Ceratoconjuntivite cicatricial bilateral associada a líquen plano: relato de caso Lichen planus leading to bilateral cicatrizing keratoconjunctivitis: case report

    Directory of Open Access Journals (Sweden)

    Camila Melo Gadelha Pereira Diniz

    2008-12-01

    Full Text Available Descrevemos um caso de ceratoconjuntivite cicatricial bilateral em uma paciente portadora de líquen plano e apresentamos revisão da literatura mundial sobre esse assunto. Cicatrização conjuntival, com formação de simbléfaro, olho seco, infiltração corneana, neovascularização e afinamento foram os sinais observados. Diagnóstico foi baseado nos achados clínicos e biópsia, após exclusão das causas típicas de ceratoconjuntivite cicatricial.To describe a case of bilateral cicatrizing keratoconjunctivitis in a patient with lichen planus and review the literature. Conjunctiva cicatrization with symblepharon formation, dry eye, corneal infiltration and neovascularization and thinning were the most observed prominent signs. Diagnosis was based on clinical findings and biopsy, after exclusion of typical causes of cicatricial keratoconjuntivitis.

  11. 口腔扁平苔藓癌变机制的研究进展%Advances of the mechanism in canceration of oral Lichen planus ( a review)

    Institute of Scientific and Technical Information of China (English)

    周荣佼; 王金燕; 姜薇; 张莉

    2007-01-01

    口腔扁平苔藓(oral lichen planus OLP)是一种口腔黏膜的慢性炎症,此病与口腔癌前病变有关[1].尽管病变机制尚不清楚,随着基因研究的发展和多聚酶链技术的应用.研究显示:错配修复基因(hMSH2)、p63基因、人乳头状瘤病毒(HPV)、爱泼斯坦-巴尔病毒(EBV)等在OLP癌变机制中发挥一定的作用.

  12. 口腔扁平苔藓癌变研究进展及争议%Research progress and controversy in oral lichen planus canceration

    Institute of Scientific and Technical Information of China (English)

    周红梅; 郭宜青; 危常磊

    2012-01-01

    口腔扁平苔藓(oral lichen planus,OLP)是一种常见的口腔黏膜慢性炎性疾病,WHO将其列入潜在恶性病变(potentially malignant disorders)的范畴.有关OLP癌变的研究目前主要集中在流行病学调查、癌变危险性预测、癌变机制、化学预防等方面,而对其是否癌变近年产生疑问和争议.本文就OLP癌变的相关研究进展进行综述.

  13. Expression and Significance of Caspase-3 in Lichen planus%扁平苔藓皮损区caspase-3的表达与意义

    Institute of Scientific and Technical Information of China (English)

    郝国华; 白莉

    2008-01-01

    目的:探讨凋亡基因caspase-3在扁平苔藓(Lichen planus ,Lp)病变中的作用.方法:采用免疫组化法对30例扁平苔藓皮损和30例正常皮肤组织凋亡相关蛋白caspase-3的表达情况进行检测.结果:扁平苔藓组caspase-3蛋白表达率高于正常对照组的表达率,差异有统计学意义(P<0.01).结论:caspase-3作为凋亡的最终效应分子,可能在扁平苔藓病变中起到重要作用.

  14. Liquen plano en el Programa de Detección Precoz del Cáncer Bucal Lichen planus in the Program for the Early Detection of Oral Cancer

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    Pedro A. Ducasse Olivera

    2005-12-01

    Full Text Available El liquen plano es una enfermedad dermatológica de origen desconocido que se manifiesta en la mucosa bucal. Se realizó un estudio retrospectivo con los pacientes pesquisados mediante el Programa de Detección Precoz del Cáncer Bucal en el municipio especial Isla de la Juventud, con el objetivo de determinar el comportamiento epidemiológico de esta entidad, distribución según sexo, raza y zona bucal mas afectada, así como establecer la relación entre la aparición de las lesiones en piel y mucosas. Según los resultados, se determinó que el liquen plano oral es más común en hombres de la tercera y sexta décadas, principalmente en mestizos y blancos, la zona más afectada fue el carrillo (42.9 % y las lesiones cutáneas aparecieron solo en 2 casos (9.5 %.Lichen planus is a dermatological disease of unknown origin that manifests itself in the oral mucosa, reason for which we decided to conduct a study on it as part of the Program for the Early Detection of Oral Cancer in the Isle of Youth special municipality with the patients screened in this program aimed at determining the epidemiological behavior of this entity, distribution by sex, race, the most affected oral zone, and the relation between the appearance of injuries in the skin and mucosas. According to the results, it was concluded that the oral lichen planus is more comon in men at the third and sixth decades of life, in mestizoes and white individuals, and that the cheek was the most affected area. The cutaneous lesions appeared only in 2 of the 21 affected cases.

  15. Lichens

    Science.gov (United States)

    Rodriguez, Cynthia M; Bennett, James P

    2012-01-01

    The prion diseases sheep scrapie and cervid chronic wasting disease are transmitted, in part, via an environmental reservoir of infectivity; prions released from infected animals persist in the environment and can cause disease years later. Central to controlling disease transmission is the identification of methods capable of inactivating these agents on the landscape. We have found that certain lichens, common, ubiquitous, symbiotic organisms, possess a serine protease capable of degrading prion protein (PrP) from prion-infected animals. The protease functions against a range of prion strains from various hosts and reduces levels of abnormal PrP by at least two logs. We have now tested more than twenty lichen species from several geographical locations and from various taxa and found that approximately half of these species degrade PrP. Critical next steps include examining the effect of lichens on prion infectivity and cloning the protease responsible for PrP degradation. The impact of lichens on prions in the environment remains unknown. We speculate that lichens could have the potential to degrade prions when they are shed from infected animals onto lichens or into environments where lichens are abundant. In addition, lichens are frequently consumed by cervids and many other animals and the effect of dietary lichens on prion disease transmission should also be considered. PMID:22453171

  16. Diagnosis and treatment on oral lichen planus combining with esophageal lichen planus and review the related literatures%口腔扁平苔藓合并食道扁平苔藓的诊治及相关文献复习

    Institute of Scientific and Technical Information of China (English)

    何健慧; 黄丰; 李容林; 赖人旭; 易先平; 李春阳

    2015-01-01

    Objective To explore and report the clinical oral lichen planus (OLP) cases combining with esophageal lichen planus(ELP), including prevalence, clinical manifestations, diagnosis, treatment and prognosis. Methods Two hundred and thirty-six OLP patients with chief-compliances and symp-tomes such as chest discomfort, chest burning, dysphagia, poor food intake et al. were included in this study. Esophagogastroscopy and biosy were suggested and applied to find weather combining with esophageal lichen planus (ELP) after written informed consent were obtained. Standard therapy of OLP and case follow-up were applied. Results Eighteen OLP patients with combined ELP were found (7.6%, 18/236). Dysplasia were detected in 2 cases 11.1%(2/18) and in 1 case, 5.5%(1/18), esophageal squamous cell carcinoma was detected while the three OLP was not malignant-transformed . Conclusions Lichen planus is general condition and there is a correlation between ELP and OLP . Thus, oral medicine doctors should pay attention to the other site lichen planus lesion to detect early and hiding malignant-transformed, avoided misdiagnosis and missed diagnosis.%目的:总结分析口腔扁平苔藓(OLP)合并食道扁平苔藓(ELP)的临床发生率、诊出方法、治疗和恶变倾向。方法对236例OLP确诊患者,根据主诉及问诊有胸部不适、胸前灼痛、烧灼感、吞咽困难、食道狭窄、进食不畅等症状,获得知情同意后进一步进行食道胃镜检查及病理活检,筛选合并ELP,进行规范治疗和追踪。结果18例出现了ELP病损,OLP合并出现ELP发生率为7.6%(18/236)。其中2例11.1%(2/18)早于OLP出现食道非典型增生,1例5.5%(1/18)已早于OLP出现恶变为食道鳞状细胞癌。结论扁平苔藓是全身性疾病,ELP和OLP均属于黏膜的慢性炎症性疾病,两者间存在关联性。口腔科医生接诊OLP患者时,应该关注其全身其他部位的病损,尽早发现其

  17. COMPARISON OF MAST CELL COUNT AND MAST CELL DENSITY IN NORMAL MUCOSA, ORAL LEUKOPLAKIA, ORAL LICHEN PLANUS, ORAL SUBMUCOUS FIBROSIS AND ORAL SQUAMOUS CELL CARCINOMA – A STUDY ON 50 CASES

    OpenAIRE

    Monica Kinra; Karthikeyan Ramalingam; Amitabha sarkar; Farzan Rehman; Girish KL

    2012-01-01

    The present study was carried out for quantitative analysis of the mean MCC/optical field and also MCD/sq. mm in oral submucous fibrosis (OSMF), oral lichen planus (OLP), oral leukoplakia (OL), oral squamous cell carcinoma (OSCC) and normal buccal mucosa which constituted control group. This study was carried out in the Department of Oral Pathology and Microbiology, Jaipur Dental College, Jaipur. Histologically confirmed 10 cases each of OSMF, OL, OLP and OSCC were selected. The sections were...

  18. 0.03%他克莫司软膏治疗口腔糜烂型扁平苔藓的疗效观察%Observation of Therapeutic Effect of 0.03 %Tacrolimus Ointment on Patients with Erosive Oral Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    祝磊; 焦静

    2012-01-01

    Objective: To investigate the effects of 0. 03% Tacrolimus ointment on patients with erosive oral lichen planus. Methods: A total of 67 cases were collected and divided into two groups randomly: 33 cases were treated with 0.03% Tacrolimus ointment (treatment group), and 30 cases with Triamcinolone acetonide and retinoic acid (control group). Results: There was significant difference between two groups of the effective rate and side-effect occurrence during the therapy within six months after treatment. Conclusion: The results of the present work demonstrate that 0. 03% Tacrolimus ointment is an effective therapy for erosive oral lichen planus.%目的:观察局部应用0.03%他克莫司软膏治疗口腔糜烂型扁平苔藓的疗效.方法:选择口腔糜烂型扁平苔藓患者67例并随机分成两组,分别用0.03%他克莫司软膏和局部注射曲安奈德联合维甲酸治疗.结果:随访观察治疗6个月后显效率及不良反应率,两组差异显著.结论:0.03%他克莫司软膏治疗口腔糜烂型扁平苔藓具有良好的临床疗效.

  19. Estudo comparativo das alterações celulares no líquen plano e no carcinoma epidermóide bucal Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa

    Directory of Open Access Journals (Sweden)

    Fernando Augusto Cervantes Garcia de Sousa

    2009-04-01

    Full Text Available Atualmente, muito se discute a respeito da natureza pré-maligna do líquen plano bucal. OBJETIVO: O presente trabalho tem como objetivo analisar as alterações das células epiteliais presentes no líquen plano bucal, comparando-as com aquelas observadas no carcinoma epidermóide. MATERIAL E MÉTODO: Cortes histológicos de líquen plano bucal e carcinoma epidermóide, corados com hematoxilina-eosina, foram analisados por meio da microscopia de luz. RESULTADO: As alterações mais frequentemente observadas no líquen plano bucal foram aumento da relação núcleo/citoplasma (93,33%, espessamento da membrana nuclear (86,67% e bi-ou multinucleação (86,67%. O teste t de Student (alfa=5% revelou haver diferença estatisticamente significante entre o número médio de alterações celulares no líquen plano bucal (5,87±1,57 e no carcinoma epidermóide (7,60±1,81. Quanto aos tipos de alterações, o teste de qui-quadrado também revelou haver diferença estatisticamente significante entre as lesões avaliadas em relação às seguintes alterações celulares: hipercromatismo nuclear, mitoses atípicas, pleomorfismo celular e diferenciação celular anormal (pCurrently, much is discussed regarding the pre-malignant nature of mouth mucosa lichen planus. AIM: The present study aims at analyzing the alterations found in the epithelial cells present in the oral cavity lichen planus, comparing them to those found in epidermoid carcinoma. MATERIALS AND METHODS: Histological cross-sections of oral lichen planus and epidermoid carcinoma, dyed by hematoxylineosin, were analyzed through light microscopy. RESULT: the most frequently found alterations in oral lichen planus were: an increase in the nucleus/cytoplasm relation (93.33%, nucleus membrane thickness (86.67% and bi-nucleus or multinucleous (86.67%. The Student t test (alpha=5% revealed a statistically significant difference between the average number of cell alterations in oral lichen planus (5.87

  20. 低氧诱导因子-1α与口腔扁平苔藓%Hypoxia-inducible factor-1α and oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    王夏夏; 孙红英

    2015-01-01

    Hypoxia-inducible factor(HIF)-1 is an important transcription factor in cellular adaptation to hypoxic conditions is involved in regulating immune cell differentiation, promoting the adhesion and influence the formation of cell metabolism, inducing new blood vessels, and regulating cell proliferation and apoptosis, among others. In recent years, studies have shown that HIF-1α may play an important role in the pathogenesis of oral lichen planus. This article reviewed the research progress onHIF-1inthe following aspects: the structure, function, and regulation of HIF-1, immune inflammatory response in the expression of HIF-1α, and the role of HIF-1α in the occurrence and development of oral lichen planus.%低氧诱导因子(HIF)-1是机体低氧反应中的重要转录因子,在免疫炎症反应中参与调控免疫细胞分化、促进黏附、影响细胞代谢、诱导新生血管形成、调控细胞增殖与凋亡等。近年研究表明,HIF-1α在口腔扁平苔藓的发生发展过程中可能发挥着重要作用,本文将从HIF-1的结构、功能及调控,免疫炎症反应中HIF-1α的表达, HIF-1α在口腔扁平苔藓发生、发展中的作用等方面作一综述。

  1. 扁平苔藓样慢性移植物抗宿主病一例%Lichen planus-type chronic graft-versus-host disease:a case report

    Institute of Scientific and Technical Information of China (English)

    徐俊涛; 周慧; 刘菡

    2016-01-01

    患者,男,40岁。躯干泛发苔藓样皮损伴瘙痒1个月。患者1年前因“急性粒细胞白血病”行异体造血干细胞移植术。皮损组织病理示基底细胞液化变性,有嗜酸性变的角质形成细胞似胶样小体,周围淋巴细胞卫星状分布,真皮浅层淋巴细胞等呈带状浸润。诊断:扁平苔藓型慢性移植物抗宿主病。%A 40-year-old male presented with lichenoid lesions over the trunk, with itching for 1 month. The patient had a history of acute myeloid leukemia and was treated with allogeneic hematopoietic stem cell transplantation 1 year ago. Histopathology of skin lesions revealed liquefaction degeneration of basal cell, civatte bodies-like keratinocyte which surrounded by lymphocytes in satellite-like distribution and banded infiltration of lymphocytes in dermis. The diagnosis of lichen planus-type chronic graft-versus-host disease was made.

  2. ALDH1在OLP和LK组织中的表达及其意义%The role of ALDH1 in oral leukoplakia and oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    许子元; 郁利; 施琳俊; 周曾同

    2014-01-01

    目的:通过检测干细胞标记物ALDH1在口腔扁平苔藓(OLP)和白斑(LK)中的表达水平,评价其与癌变的关系。方法:采用免疫组织化学SP法检测ALDH1在10例正常口腔黏膜,30例OLP,60例LK,10例口腔鳞癌(OS-CC)中表达水平;再检测ALDH1在30例癌变与30例未癌变LK中的表达差异。结果:ALDH1在正常口腔黏膜中不表达,在OLP、LK和OSCC中的表达率分别为26.7%,63.3%和90.0%(P<0.05);ALDH1在未癌变和癌变LK中的表达率分别是43.3%和83.3%(P<0.01)。结论:ALDH1与口腔黏膜恶性潜能程度相关,可能是预测癌变的分子标记物。%Objective:To investgate the role of stem cell marker ALDH1 in oral carcinogenesis process. Method:ALDH1 expression in 10 cases of normal oral mucosa,30 cases of oral lichen planus,60 cases of oral leukoplakia,10 cases of oral squamous cell carcinoma was detected by immunohistochemistry. And the difference of ALDH1 expression in 30 cas-es of untransformed leukoplakia and 30 cases of malignant-transformed leukoplakia was detected. Result:ALDH1 was not found in normal oral mucosa,and it was found in 26.7 %,63.3%and 90.0%of oral lichen planus,oral leukoplakia and o-ral squamous cell carcinoma,respectively (P <0.05);ALDH1 expression rate in untransformed leukoplakia and transformed leukoplakia was 43.3 % and 83.3 %(P <0.01). Conclusion:ALDH1 correlated with malignant potential of oral mucosa, and it may be a marker of malignant transformation.

  3. Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus.

    Science.gov (United States)

    de Carvalho, Gabriel Costa; Domingues, Rosana; de Sousa Nogueira, Marcelle Almeida; Calvielli Castelo Branco, Anna C; Gomes Manfrere, Kelly C; Pereira, Naiura Vieira; Aoki, Valéria; Sotto, Mirian Nacagami; Da Silva Duarte, Alberto J; Sato, Maria Notomi

    2016-05-01

    Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The inflammatory status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation of cytotoxic cells. The aims of this study were to evaluate S100A8 expression in skin lesions and the in vitro effects of S100A8 on CD8+ T cells and natural killer (NK) cells in LP. Increased levels of S100A8/S100A9 were detected in the skin lesions as well as in the sera of subjects with LP. S100A8 expression induced an increased cytotoxic response by peripheral blood CD8+CD107a+ T cells as well as by NK CD56bright cells in patients with LP. Increased expression of interleukin (IL)-1?, tumour necrosis factor (TNF) and IL-6 in the CD8+ T cells of patients with LP was induced by S100A8, in contrast to the control group that produced IL- 10 and interferon type I genes. These data suggest that, in individuals with LP, S100A8 may exert distinct immunomodulatory and cytotoxicity functions.

  4. Immunohistochemical Analysis of the Activation Status of the Akt/mTOR/pS6 Signaling Pathway in Oral Lichen Planus

    Directory of Open Access Journals (Sweden)

    Georgios Prodromidis

    2013-01-01

    Full Text Available Introduction. Aberrations of the Akt/mTOR/pS6 pathway have been linked to various types of human cancer, including oral squamous cell carcinoma (OSCC. The purpose of this study was to evaluate the activation status of Akt, mTOR, and pS6 in oral lichen planus (OLP in comparison with oral premalignant and malignant lesions and normal oral mucosa (NM. Materials and Methods. Immunohistochemistry for p-Akt, p-mTOR, and phospho-pS6 was performed in 40 OLP, 20 oral leukoplakias (OL, 10 OSCC, and 10 control samples of NM. Results. Nuclear p-Akt expression was detected in the vast majority of cases in all categories, being significantly higher in OL. Cytoplasmic p-Akt and p-mTOR staining was present only in a minority of OLP cases, being significantly lower compared to OL and OSCC. Phospho-pS6 showed cytoplasmic positivity in most OLP cases, which however was significantly lower compared to OL and OSCC. Conclusions. Overall, cytoplasmic p-Akt, p-mTOR, and phospho-pS6 levels appear to be significantly lower in OLP compared to OL and OSCC. However, the expression of these molecules in a subset of OLP cases suggests that activation of Akt/mTOR/pS6 may occur in the context of OLP, possibly contributing to the premalignant potential of individual cases.

  5. A combinative analysis of gene expression profiles and microRNA expression profiles identifies critical genes and microRNAs in oral lichen planus.

    Science.gov (United States)

    Liu, Qing; Wang, Xinwen; Liu, Yuan; Wei, Minghui; Chen, Lihua

    2016-08-01

    Oral lichen planus (OLP) is a chronic inflammatory disease but aetiology and pathogenesis has not fully elucidated. To gain insight into the mechanism of OLP, bioinformatic analysis was performed in this study. GSE38616 and GSE38615 were downloaded from GEO, including 7 cases of OLP and 7 healthy controls. Differentially expressed genes (DEGs) and miRNAs (DEMs) between OLP and control were screened with package Limma of R. Potential regulatory miRNAs were screened via gene set enrichment analysis. A protein-protein interaction network was constructed for the DEGs. KEGG pathways for DEGs were revealed using Gene Set Analysis Toolkit V2. After DEGs and DEMs were obtained, potential regulatory miRNAs of the DEGs were revealed and only miR-362 was differentially expressed in OLP compared with DEMs. Four targets of miR-362 were SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2), vesicle-associated membrane protein 4 (VAMP4), leucine rich repeat transmembrane neuronal 4 (LRRTM4) and lysine (K)-specific demethylase5C (KDM5C). Identified DEGs were significantly enriched in olfactory transduction and ribosome pathways. miR-362, targeting SRGAP2 and VAMP4, may be a potential risk miRNA to regulate OLP. The findings may provide potential biomarkers for diagnosis or treatment of the disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Salivary and serum levels of tumor necrosis factor-alpha in oral lichen planus: a systematic review and meta-analysis study.

    Science.gov (United States)

    Mozaffari, Hamid Reza; Ramezani, Mazaher; Mahmoudiahmadabadi, Mohammad; Omidpanah, Neda; Sadeghi, Masoud

    2017-09-01

    Tumor necrosis factor-α (TNF-α) has a role in the progression of the oral lichen planus (OLP). The aim of this meta-analysis study was to evaluate the salivary and serum TNF-α levels in patients with OLP. We searched in the databases of PubMed/Medline, Science direct, Scopus, Web of Science, and Cochrane Library for studies reported from 1983 to 2016. All studies were checked for evaluation of salivary and serum levels of TNF-α in patients with OLP compared with healthy controls. Twelve studies were included in the meta-analysis. The mean difference of 7 studies reporting salivary TNF-α levels in patients with OLP versus healthy controls was 25.90 pg/mL (95% confidence interval [CI] 15.31-36.49; P < .00001) and 7 studies reporting serum TNF-α levels was 1.65 pg/mL (95% CI -0.82 to 4.11; P = .19). In patients with OLP, the higher levels of TNF-α in saliva compared with serum suggest that measurement of this marker in saliva may be more useful than in serum for determining diagnostic and therapeutic aims. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Clinical trial analyzing the impact of continuous defocused CO2 laser vaporisation on the malignant transformation of erosive oral lichen planus.

    Science.gov (United States)

    Mücke, Thomas; Gentz, Irina; Kanatas, Anastasios; Ritschl, Lucas M; Mitchell, David A; Wolff, Klaus-Dietrich; Deppe, Herbert

    2015-10-01

    The erosive oral lichen planus (OLP) represents a management challenge to the clinician and can have debilitating consequences to patients' quality of life. The aims of this work were to determine the incidence of malignant transformation to squamous cell carcinoma (SCC) in patients undergoing traditional symptomatic treatments (oral salve containing lidocaine hydrochloride or systemic diclofenac) compared to patients that were managed with a defocused continuous CO2 laser beam. A total of 171 patients with histologically confirmed erosive OLP were included into this study. After treatment, patients were assessed until completion of wound healing, at least every 3-6 months for the first 2 years, and every 6-12 months thereafter. The study included 87 women (50.9%) and 84 men (49.1%). A total of 103 patients (60.2%) underwent symptomatic conservative treatment, and 68 patients (39.8%) underwent continuous defocused CO2 laser treatments. SCC developed in 16 patients (9.4%), 2 patients (2.9%) after continuous defocused CO2 laser treatment and 14 patients (13.6%) with symptomatic treatment only. This study provides insight into the potential impact of the CO2 laser in the management of patients with erosive OLP and the influence on the recurrence rate of erosive OLP, as well as malignant transformation to oral SCC.

  8. Lichen striatus associated with psoriasis vulgaris treated with oral acitretin

    Directory of Open Access Journals (Sweden)

    Enzo Errichetti

    2014-01-01

    Full Text Available Lichen striatus (LS is an uncommon dermatosis of unknown etiology that presents as a continuous or interrupted linear band of pink, tan, red or skin-colored papules in a blaschkoid distribution. The lesions are generally solitary and unilateral, but unusual extensive cases with multiple and bilateral lesions have been also described. Albeit LS is typically an asymptomatic and self-limited dermatosis, it may cause a significant psychological distress in some patients, thus requiring an appropriate therapy. Topical steroid is the most commonly used treatment but it is not always effective. We report a case of LS unresponsive to topical steroid therapy associated with psoriasis vulgaris successfully treated with oral acitretin.

  9. Efficacy Evaluation of Tacrolimus Ointment and Kouyanqing Granules in Treatment of Erosive Oral Lichen Planus%他克莫司软膏加口炎清颗粒治疗糜烂型口腔扁平苔藓的短期疗效评价

    Institute of Scientific and Technical Information of China (English)

    曾宪涛; 姚馨蕙; 耿发云

    2011-01-01

    目的 评价0.03%他克莫司软膏加口炎清颗粒治疗糜烂型口腔扁平苔藓患者的疗效.方法 80例糜烂型口腔扁平苔藓患者,试验组和对照组各40例.试验组用0.03%他克莫司软膏加口炎清颗粒治疗,对照组用0.02%丙酸氯倍他索软膏治疗.结果 治疗4周后试验组总有效率为92.50%,对照组为65.00%,差异有统计学意义(χ2=9.038,P<0.05).试验组和对照组的不良反应率分别为12.50%(5/40)和17.50%(7/40),差异无统计学意义(χ2=0.392,P>0.05).结论 0.03%他克莫司软膏加口炎清颗粒治疗糜烂型口腔扁平苔藓患者短期疗效可靠.%Objective To evaluate the effect of 0.03% Tacrolimus ointment and kouyanqing granules on treatment of erosive oral lichen planus. Methods Eighty cases of erosive oral lichen planus were randomly divided into control group and observation group, and control group were treated with clobetasol propionate ointment, while observation group were treated with 0.03% tacrolimus ointment and kouyanqing granules. Results After4-weeks' treatment, the total efficacy rate of the observation group is higher than that of the control group, with significant difference. Conclusion Kouyanqing granules and 0.03% tacrolimus ointment has good curative effect on treatment of erosive oral lichen planus .

  10. MMP-9和 Fascin 蛋白在口腔扁平苔藓中的表达及相关性研究%Expression and correlation of MMP-9 and Fascin in oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    刘长欢; 金玲; 丁丽娜; 陈英新

    2016-01-01

    Objective To examine the expression and correlation of MMP-9 and Fascin in oral lichen planus(OLP). Methods The expression of MMP-9 and Fascin in 35 cases of normal oral mucosa,45 cases of oral lichen planus and 46 cases of oral squamous cell carcinoma(OSCC)was examined by immunohistochemical technique.The data was analyzed by SPSS,a exact test using software package.Results the expression of MMP-9 in normal oral mucosa,oral lichen pla-nus and oral squamous cell carcinoma rises in turn.The positive rate respectively is 11.4%(4/35)、66.7%(30/45)、89. 1%(41/46),the comparison among groups is statistically significant(P <0.05);The expression of Fascin in normal o-ral mucosa,oral lichen planus and oral squamous cell carcinoma rises in turn.The positive rate respectively is 0%(0/35)、15.6%(7/45)、69.6%(32/46),the comparison among groups is statistically significant(P <0.05);In oral lichen planus,the expression of MMP-9 is positively correlative with that of Fascin(P <0.05).Conclusion MMP-9 and Fas-cin not only respectively paly an important role in cancerous progress of oral lichen planus but also the two factor work together to promote the cancerous progress.%目的:检测 MMP-9和 Fascin 蛋白在口腔扁平苔藓中的表达情况,探讨两者在扁平苔藓发病机制中的作用及相关性。方法采用免疫组化技术检测 MMP-9和 Fascin 蛋白在35例口腔正常黏膜组织、45例口腔扁平苔藓和46例口腔鳞状细胞癌组织中的表达。应用 SPPSS 软件对实验结果进行卡方检验和 Spearman 相关分析。结果MMP-9在口腔正常黏膜组织、口腔扁平苔藓和口腔鳞状细胞癌组织中的表达依次增高,表达率分别为11.4%(4/35)、66.7%(30/45)、89.1%(41/46),组间差别有统计学意义(P <0.05);Fascin 在口腔正常黏膜组织、口腔扁平苔藓和口腔鳞状细胞癌组织中的表达率依次增高表达率分别为0%(0/35)、15.6%(7/45

  11. Study on the correlation between Candida albicans and oral lichen planus%白色念珠菌与口腔扁平苔藓的相关性研究

    Institute of Scientific and Technical Information of China (English)

    马海英

    2015-01-01

    Objective To investigate the correlation between Candida albicans and oral lichen planus. Method Selected non-erosive type oral lichen planus patients as observation group 1 (n=40) and erosive type oral lichen planus patients as observation group 2 (n=36). Who had no oral diseases were selected as control group (n=40). Adopted a cotton swab sampling on sabouraud agar, after 24~48 hours, observed colony morphology of 37℃culture medium, identiifcated different strains, compared candida infection rate. Through the detection of fungi, 76 patients with oral lichen planus measuring oral lesion area were divided into>2 cm2 and<2 cm2, compared infection rate of the two groups. Result Candida albicans detection rate of observation group 1, observation group 2 and control group was 32.5%, 69.4%and 7.5%respectively, the difference between the three groups was signiifcant (P<0.05). Candida albicans detection rate in lesion area of observation group was 47.6.%and 23.5%, the difference between the two groups was signiifcant (P<0.05). Conclusion Erosive and non-erosive type oral lichen planus is concerned with Candida albicans infection, psoriasis area is concerned with, infection rate, Candida albicans can induce and aggravate oral lichen planus.%目的:探讨白色念珠菌与口腔扁平苔藓的相关性。方法选取本院非糜烂型口腔扁平苔藓患者40例及糜烂型口腔扁平苔藓患者36例分别作为观察1组和观察2组,选取40例无口腔疾患的健康者作为对照组。应用棉拭子法采样,于沙氏琼脂培养基中37℃培养24~48小时后观察菌落形态,鉴定不同菌种,比较合并白色念珠菌感染率。测量通过真菌检测后的76例口腔扁平苔藓患者口腔皮损面积,比较不同口腔皮损面积患者白色念珠菌的感染率。结果观察1组、观察2组及对照组白色念珠菌检出率分别为32.5%、69.4%和7.5%,组间比较差异显著(P<0.05)。口腔皮损面积型>2 cm2和<2

  12. The Expression and Significance of HGF and MMP-9 in Lichen Planus%HGF和MMP-9在扁平苔藓皮损中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    何肖; 白莉

    2011-01-01

    目的 检测扁平苔藓皮损中肝细胞生长因子(HGF)和基质金属蛋白酶-9(MMP-9)的表达情况,探讨其在扁平苔藓发病中的意义.方法 应用免疫组化法和RT-PCR法测定30例扁平苔藓及30例正常皮肤组织中HGF和MMP-9的表达水平.结果 扁平苔藓组中HGF和MMP-9的表达率均高于正常对照组(P<0.01),且二者在扁平苔藓皮损中的表达呈正相关(r1=0.391,P1=0.032;r2=0.375,P2=0.041).结论 HGF和MMP-9的高表达可能参与了扁平苔藓的发病.%Objective To explore the expression of hepatocyte growth factor( HGF ) and metalloproteinase - 9( MMP - 9 ) in lichen planus,and investigate the function in pathogenesis of lichen planus.Methods The expression of HGF and MMP - 9 was assayed by RT - PCR and immunohistochemistry in 30 LP lesions and 30 normal skins.Results The expression of HGF and MMP - 9 in LP lesions was stronger than that in normal skins( P <0.01 ),and HGF was positively related to the expression of MMP -9 in LP lesions ( r1 =0.391 ,P1 = 0.032; r2 = 0.375, P2 = 0.041 ).Conclusion The increased expression of HGF and MMP -9 may contribute to the formation and progression of lichen planus.

  13. NursingInterventionwithChineseHerbalMedicineontheImpactofOralLichenPlanus%护理干预配合中草药对口腔扁平苔藓的影响

    Institute of Scientific and Technical Information of China (English)

    王丽娟

    2013-01-01

    Objective Explore the nursing intervention with herbal efficacy of oral lichen planus, and the degree of oral mucositis associated with clinical efficacy. Methods In our hospital dental clinic clinical diagnosis and oral pathology diagnosis of Erosive Oral Lichen Planus 40 patients. Chinese herbal medicine given treatment group and control group was given the order Pixin sprays. Results Two months after the referral, come nursing intervention with herbal oral lichen planus is the most effective and safe ways to improve the image of T lymphocytes in peripheral blood of patients with a clear two-way adjustment, while improving the body's immune force. Conclusion After long-term clinical exploration and research, Chinese herbal medicine in the treatment of oral lichen planus, not only can markedly improve the patient's local symptoms, but also to regulate their body immune function, healing rarely relapse, so as to achieve the role of tackling the problem.%  目的探讨护理干预配合中草药对口腔扁平苔藓的疗效,以及口腔黏膜炎程度与临床疗效的相关性。方法通过对我院口腔科门诊中临床诊断及口腔病理学确诊为糜烂型口腔扁平苔藓40例患者。给予治疗组中草药制剂,对照组给予的令皮欣喷雾剂。结果2个月后复诊,得出护理干预配合中草药是对口腔扁平苔藓最有效的、安全的方法之一,提高了患者外周血像中T淋巴细胞有明显的双向调节作用,同时提高了机体的免疫力。结论经过长期的临床探索和研究,中草药在治疗口腔扁平苔藓方面,不仅能显效的改善患者的局部症状,还能调节其全身免疫功能,愈合很少复发,从而达到标本兼治的作用。

  14. Logistic regression analysis of risk factors of oral lichen planus%口腔扁平苔藓发病相关风险因素的Logistic回归分析

    Institute of Scientific and Technical Information of China (English)

    郝玉娥

    2014-01-01

    Objective:To investigate and analyze the may causes of oral lichen planus ( OLP) risk factors,provide a theoretical basis for the prevention and treatment of lichen planus. Methods:Selected a qualified 130 patients with oral lichen planus,with the recent health examination in our hospital 130 cases of non-oral mucosal disease control study,the relevant survey data row two categories multivariate logistic regression analysis,to screen for risk factors associ-ated with the onset of OLP. Results:Logistic regression analysis showed that psychological factors,gastritis,local chemical stimulation and autonomic disor-ders with OLP was significantly correlated with the incidence. Conclusion:Onset and progression of oral lichen planus and multiple factors,Clinical cause of treatment should be to promote effective prevention and prognosis of OLP.%目的:对可能导致口腔扁平苔藓( OLP)发病的相关风险因素进行调查分析,为防治OLP提供理论依据。方法:选取符合条件的OLP患者130例,与近期在我院健康体检的130例非口腔黏膜病患者进行对照研究,将相关调查数据行二分类多因素Logistic回归分析,以筛查OLP发病的相关风险因素。结果:经Logistic回归分析结果显示,心理因素、胃炎、局部理化刺激和植物神经紊乱与OLP发病具有显著相关性。结论:OLP发病及病情进展与多因素有关,临床应有效进行病因治疗以促进OLP的预防及预后。

  15. 阿维A联合复方甘草酸苷治疗扁平苔藓的近期疗效观察%The observation of short-term efficacy of the combination of Avermectin A and Compound Glycyrrhizin in treatment of lichen planus

    Institute of Scientific and Technical Information of China (English)

    黄文清; 陈建浩

    2014-01-01

    Objective To observe the short-term efficacy of the combination of Avermectin A and Compound Glycyrrhizin in treatment of lichen planus. Methods A total of 60 patients with lichen planus were divided into two groups,which was treated with combination of Avermectin A and Compound Glycyrrhizin and oral Compound Glycyrrhizin tablets for 8 weeks,respectively. Results The effective rate was 83.33%and 56.67%respectively.The cure rate was 53.33%and 23.33%respectively.There was significant difference in effectiveness and cure rate among the two groups (P<0.05).There was no severe ADRs among the two groups. Conclusion The short-term efficacy of the combination of Avermectin A and Compound Glycyrrhizin in treatment of lichen planus is good and safe.%目的:观察阿维A联合复方甘草酸苷治疗扁平苔藓的近期疗效。方法将60例扁平苔藓患者随机分为2组,治疗组给予阿维A联合复方甘草酸苷口服治疗;对照组单纯给予口服复方甘草酸苷。治疗8周后判定2组疗效。结果治疗组、对照组总有效率分别为83.33%,56.67%,痊愈率分别为53.33%,23.33%,2组总有效率和痊愈率比较差异均有统计学意义(P<0.05)。2组患者均未出现严重的不良反应。结论阿维A联合复方甘草酸苷治疗扁平苔藓近期疗效好、安全,值得临床推广。

  16. Human endogenous retrovirus expression is inversely related with the up-regulation of interferon-inducible genes in the skin of patients with lichen planus.

    Science.gov (United States)

    Nogueira, Marcelle Almeida de Sousa; Gavioli, Camila Fátima Biancardi; Pereira, Nátalli Zanete; de Carvalho, Gabriel Costa; Domingues, Rosana; Aoki, Valéria; Sato, Maria Notomi

    2015-04-01

    Lichen planus (LP) is a common inflammatory skin disease of unknown etiology. Reports of a common transactivation of quiescent human endogenous retroviruses (HERVs) support the connection of viruses to the disease. HERVs are ancient retroviral sequences in the human genome and their transcription is often deregulated in cancer and autoimmune diseases. We explored the transcriptional activity of HERV sequences as well as the antiviral restriction factor and interferon-inducible genes in the skin from LP patients and healthy control (HC) donors. The study included 13 skin biopsies from patients with LP and 12 controls. Real-time PCR assay identified significant decrease in the HERV-K gag and env mRNA expression levels in LP subjects, when compared to control group. The expressions of HERV-K18 and HERV-W env were also inhibited in the skin of LP patients. We observed a strong correlation between HERV-K gag with other HERV sequences, regardless the down-modulation of transcripts levels in LP group. In contrast, a significant up-regulation of the cytidine deaminase APOBEC 3G (apolipoprotein B mRNA-editing), and the GTPase MxA (Myxovirus resistance A) mRNA expression level was identified in the LP skin specimens. Other transcript expressions, such as the master regulator of type I interferon-dependent immune responses, STING (stimulator of interferon genes) and IRF-7 (interferon regulatory factor 7), IFN-β and the inflammassome NALP3, had increased levels in LP, when compared to HC group. Our study suggests that interferon-inducible factors, in addition to their role in innate immunity against exogenous pathogens, contribute to the immune control of HERVs. Evaluation of the balance between HERV and interferon-inducible factor expression could possibly contribute to surveillance of inflammatory/malignant status of skin diseases.

  17. TNF-α, TNF-β and IL-10 gene polymorphism and association with oral lichen planus risk in Saudi patients

    Directory of Open Access Journals (Sweden)

    Maha Ali AL-MOHAYA

    2015-06-01

    Full Text Available Objectives Oral lichen planus (OLP is a chronic inflammatory oral mucosal disease. Cytokines play an important role in the pathogenesis and disease progression of OLP. Various reports have implicated cytokine gene polymorphisms in susceptibility to develop some immune mediated conditions including OLP. The purpose of this study was to investigate the association of tumor necrosis factor (TNF-α, TNF-β and interleukin (IL-10 gene polymorphisms with the OLP risk. Material and Methods Forty two unrelated patients with OLP and 211 healthy volunteers were genotyped for TNF-α (-308 G/A, TNF-β (+252A/G, IL-10 (-1082G/A, IL-10 (-819C/T, and IL-10 (-592C/A polymorphisms. Results The frequencies of allele A and genotype GA of TNF-α (-308G/A were significantly higher while allele G and GG genotypes were lower in OLP patients as compared to the controls (P0.05. However, haplotype ATA extracted from 1082G/A, -819C/T, -592C/A polymorphisms of IL-10 were more prevalent in OLP patients when compared to controls indicating its possible association with OLP susceptibility. Conclusion It is concluded that TNF-α (-308G/A, TNF-β (+252A/G and IL-10 (-1082G/A, -819C/T and -592C/A polymorphisms are associated with the susceptibility of OLP, thus giving additional support for the genetic basis of this disease.

  18. The effect of triamcinolone acetonide dental paste in the treatment of erosive oral lichen planus%曲安奈德口腔软膏治疗糜烂型口腔扁平苔藓临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    李勉香; 吴桐; 杨灵澜; 李晓旭; 王娟; 夏娟

    2016-01-01

    60 patients with pathologically diagnosed erosive lichen planus of bilateral buccal mucosa were included.The lesion on one side was treated by local application of triamcinolone acetonide dental paste(test group),the lesion on the other side without treatment was used in the control group.7,1 4,21 and 28 d after treatment the pain level and the lesion situation scores in the test group decreased significantly (P <0.001 ),and lower than those in the control group at the same time point(P <0.05).No adverse reaction was found in the 2 groups. Triamcinolone Acetonide Dental Paste is effective in the treatment of erosive oral lichen planus.%纳入60例经病理检查确诊的双侧颊黏膜为糜烂型扁平苔藓患者,以患者的一侧病损为试验组,患处涂抹曲安奈德口腔软膏,另一侧为对照组(不予任何治疗)。分别于初诊、第1、2、3、4周记录患者疼痛程度和糜烂面积的变化。用药后1、2、3、4周试验组患者的疼痛程度和糜烂面积明显改善(P <0.05),且优于同时间点的对照组(P <0.001)。2组均未见有不良反应。结果表明应用曲安奈德口腔软膏能有效治疗糜烂型口腔扁平苔藓。

  19. Expression of telomerase reverse transcriptase mRNA in oral lichen planus%端粒酶逆转录酶mRNA在口腔扁平苔藓中的表达

    Institute of Scientific and Technical Information of China (English)

    程曼莉; 杨亦萍; 曹阳; 何克新

    2010-01-01

    目的 探讨端粒酶逆转录酶(TERT)mRNA在口腔扁平苔藓(OLP)中的表达及临床意义.方法 采用原位杂交(ISH)的方法,检测了20例糜烂型扁平苔藓(erosive oral lichen planus,eOLP)、20例非糜烂型扁平苔藓(non-erosive oral lichen planus,neOLP)和12例正常口腔黏膜TERT mRNA的表达.结果 糜烂型OLP的TERT mRNA阳性率明显高于非糜烂型OLP的TERT mRNA阳性率(P<0.05).糜烂型OLP与非糜烂型OLP染色强度相比有统计学意义(P<0.05).结论 糜烂型OLP的上皮细胞可能比非糜烂型OLP的上皮细胞处于更高的增殖状态.

  20. Lichen Striatus in a UVB Treated Adult Psoriasis Patient

    Directory of Open Access Journals (Sweden)

    Pınar Özuğuz

    2014-06-01

    Full Text Available Lichen striatus is a self-limited lichenoid eruption that follows Blaschko’s lines. It is particularly common in children and rarely seen in adults. Cases related to atopic diathesis are common, besides it is reported among family members. Viral infections, vaccines and trauma related cases are also present. Various environmental stimuli in the setting of genetic predisposition may play a role. We herein, reported a forty eight year-old woman who developed lichen striatus eruptions in her arm and trunk while she was receiving UVB treatment with maintenance dose for psoriasis. Phototherapy might act as a stimulant with its immunosuppressive and traumatic effects.

  1. 口炎清胶囊治疗口腔扁平苔藓疗效分析%Clinical effect of capsules Kouyanqing on treatment of oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    李鹏飞; 谭颖徽; 张纲; 裘松波; 陈勇鹏; 卢来春

    2011-01-01

    Objective To estimate the effective of capsules Kouyanqing to treat OLP. Methods Patients were divided into controlled and experiment groups. The controlled group were treated with Hypoglaucum and vitamin B as well as oral ulcer oil if necessary,while the experiment group were treated with Capsules Kouyanqing and vitamin B as well as oral ulcer oil if necessary. The short-term (4 weeks) and long-term (6 months) effects were observed. Results ShortteRm (4 weeks)and long-term (6 months) effects of experiment group were significantly better than that of the controlled group. Conclusion The capsules Kouyanqing combined with vitamin B adjust the immunity of human body, repair the damaged oral mucosa, thus reduce the recurring.%目的 观察中成药口炎清胶囊治疗口腔扁平苔藓(Oral Lichen Planus,OLP)的疗效.方法 对我院196例OLP患者随机分为治疗组及对照组.对照组采用昆明山海棠加复合维生素B,辅助口腔溃疡油进行治疗;治疗组采用我院自发研制的中成药口炎清胶囊加复合维生素B,辅助口腔溃疡油进行治疗.比较两组的近期(4周)和远期(6个月)疗效.结果 治疗组的近期和远期有效率均显著高于对照组,差异有统计学意义(P<0.05).结论 采用中成药口炎清胶囊治疗OLP能发挥各君臣药的互补作用,而复合维生素B含有多种辅酶,能参与体内多种营养物质代谢反应.该治疗方法通过调节机体的免疫机制,有利于口腔黏膜细胞的修复,巩固疗效,减少复发,疗效满意.

  2. Clinical analysis on 684 patients with Oral Lichen Planus%684例口腔黏膜扁平苔藓临床分析

    Institute of Scientific and Technical Information of China (English)

    万哲; 吴泽钰; 美力班·吐尔逊; 薛瑞

    2016-01-01

    目的:探讨新疆地区口腔扁平苔藓的患病情况及分布特点,为口腔扁平苔藓的防治提供依据。方法收集2012年9月-2014年5月新疆医科大学第一附属医院口腔黏膜科门诊初、复诊的口腔黏膜扁平苔藓患者的临床资料,并对疾病的病损类型、病损部位、民族、性别及年龄分布进行分析。结果口腔黏膜扁平苔藓以女性患者居多(75.15%),患者的民族以汉族多见(90.79%),患者口腔的病损部位以颊黏膜多见(71.27%)。结论口腔扁平苔藓在新疆地区人群中仍属于常见且易复发的口腔黏膜病。%Objective To explore the clinical features of Oral Lichen Planus (OLP)patients in Xinjiang to provide the basis for prevention and treatment of OLP.Methods A total of 684 patients with histologically and clinically confirmed as OLP were collected from Department of Oral Mucosa in the First Affiliated Hospital of Xinjiang Medical University between Sept 2012 and May 2014 to describe the clinical character-istics of OLP patients.Results Among the 684 patients,women acounted for 75.15% and HAN acounted for 90.79%,in which the buccal mucosa was the most common site (71.27%).Conclusion OLP is a com-mon and easy-to-recurrence oral mucosal disease in Xinjiang populationand.

  3. IMMUNOREGULATORY EFFECTS OF TAIXIANNING DECOCTION IN PATIENTS WITH ORAL LICHEN PLANUS%苔藓宁对口腔扁平苔藓患者的免疫调节作用

    Institute of Scientific and Technical Information of China (English)

    张子建; 冯艳红; 李立芳; 高毅; 李敏

    2012-01-01

    Objective To explore the effect and immunoregulation of taixianning decoction on oral lichen planus( OLP ) patients. Methods Fifty - one OLP patients were required to take taixianning decoction for 3 months. Then, the therapeutic effect and change of humoral immunity and cellular immunity were compared with those of patients who took western medicine. Results The total effective rate of taixianning decoction group and western medicine group were 88. 2% and 72. 5% respectively. Compared with western medicine group, taixianning decoction group had higher therapeutic effect( P < 0. 05 ). The index of humoral immunity and cellular immunity was notably changed ( P < 0. 05 )after the treatment with taixianning decoction, closing to the normal value. After the treatment with western medicine, there was no notable change. Conclusion Taixianning decoction have better curative effect to improve immunological function of oral lichen planus patients.%目的 观察苔藓宁对口腔扁平苔藓(oral lichen planus,OLP)患者免疫功能的影响及调节作用.方法 51例OLP患者连续服用中药方剂苔藓宁3个月,对比西药治疗方法,观察其疗效以及对OLP患者体液免疫和细胞免疫的调节作用.结果 苔藓宁治疗组总有效率88.2%,西药治疗组为72.5%,2组疗效差异有统计学意义(P<0.05).苔藓宁治疗组患者治疗后,体液免疫和细胞免疫趋于正常,与治疗前比较差异有统计学意义(P<0.05),西药治疗组治疗前后各项免疫指标的变化差异无统计学意义(P>0.05).结论 苔藓宁对OLP患者的免疫功能具有调节作用,能有效改善患者的临床症状,疗效显著.

  4. Expression and significance of serum RANTES and IL-16 in patients with oral lichen planus%口腔扁平苔藓患者血清RANTES及IL-16表达水平及其临床意义

    Institute of Scientific and Technical Information of China (English)

    张成仁; 葛娅娜; 靳慧; 王秀梅; 张梅兮

    2011-01-01

    Objective To explore the levels of regulated on activation, normal T-cell expressed and secreted( RANTES)and interleukin-16( IL-16)in serum from patients with oral lichen planus(OLP) and to identify their pathological role and the clinical significance. Methods Sixty two patients with oral lichen planus were divided into 5 groups according to OLP severity and 22 healthy volunteers were used as control. Serum levels of RANTES and IL-16 were measured by enzyme linked immunosorbent assay (ELISA). Results Serum levels of RANTES and IL-16 were significantly increased in OLP patients compared with healthy subjects( P < 0. 05 ). And positive statistical correlations existed between the level of RANTES, IL-16 and clinical severity (r=0.2647, P<0. 0151;r =0. 2580, P<0.0241). Conclusion RANTES and IL-16 are involved in the inflammatory reaction and the pathogenesis of OLP, and the levels of RANTES and IL-16 may be useful biomarkers for OLP severity.%目的 检测口腔扁平藓(oral lichen planus,OLP) 患者血清调节活化正常T细胞表达和分泌因子(regulated on activation,normal T-cell expressed and secreted,RANTES)及白细胞介素-16(interleukin-16,IL-16)的表达水平变化,探讨其在OLP病理过程中的作用及其临床意义.方法 口腔扁平苔藓患者62例,按照病情严重程度分为5组,另选22例健康志愿者作对照组,采用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测各组的血清RANTES及IL-16水平.结果 OLP患者血清RANTES和IL-16水平均较健康对照组显著增高(P<0.05),并且RANTES与IL-16水平与临床病损严重程度呈正相关(r=0.2647,P<0.0151;r=0.2580,P<0.0241).结论 RANTES和IL-16参与OLP的炎症反应及其病理过程,可能为OLP病损严重程度的评价提供参考.

  5. Distribution of Langerhans cell in oral lichen planus%朗格罕斯细胞的分布、变化与口腔扁平苔藓发病及病变程度的关系

    Institute of Scientific and Technical Information of China (English)

    刘青; 吴织芬; 金岩; 李媛

    2001-01-01

    目的:为进一步探讨口腔扁平苔藓的发病机制.方法:采用免疫组织化学方法,使用郎格罕斯细胞特异性标记CD1a单克隆抗体对35例口腔扁平苔藓(oral lichen planus,OLP)进行研究.结果:CDla+的郎格罕斯细胞(Langerhans cell,LC)较对照组明显增多.分布更趋于上皮棘层及粒层,树突增多、增长.其数量和表达程度与OLP病程、病变程度相关,不同组间有高度显著性(P<o.01).结论:LC在OLP的发病、发展中具有重要作用.

  6. 丙型肝炎病毒与扁平苔藓相关性研究%The Study of the Relation between Hepatitis C Virus and Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    鲍修增; 王岚; 王迎; 金晓明

    2003-01-01

    为了确定丙型肝炎病毒(hepatitis C virus,HCV)与扁平苔藓(lichen planus,LP)之间是否存在某种联系以及丙型肝炎抗原(hepatitis C antigen,HCAg) 阳性表达与LP患者性别的关系,应用sABC免疫组织化学染色法对31例LP患者的病理切片进行了分析.结果显示,HCV在LP的发病机理中的作用不可忽视;LP患者中HCAg的表达虽然在不同的性别中表现形式有所不同,但无统计学意义.

  7. Study on the Correlation of P27 in Oral Lichen Planus%口腔扁平苔藓上皮组织P27表达的研究

    Institute of Scientific and Technical Information of China (English)

    尚云峰; 黎逢保; 付本燕

    2009-01-01

    目的:通过研究口腔扁平苔藓(Oral Lichen Planus,OLP)患者口腔黏膜上皮P27蛋白的表达的变化,探讨OLP发病的机理.方法:用免疫组化SABC法检测30例OLP患者及20例正常对照者口腔P27蛋白在两组上皮中的分布和表达.结果:OLP组与正常组凋亡细胞阳性表达率分别为5.63±2.74及5.61±1.82,t=0.0407,P>0.05无统计学意义.结论:P27蛋白与OLP的发病无关.

  8. A Comparative Evaluation of Efficacy of Tacrolimus and Triamcinolone Acetonide in the Management of Symptomatic Oral Lichen Planus

    Directory of Open Access Journals (Sweden)

    Y M Swarna

    2011-01-01

    Interpretation and conclusion Topical tacrolimus 0.03% ointment induced better initial therapeutic response than triamcinolone acetonide 0.1 % ointment. However, relapses occurred in two subjects in group ′A′ and three subjects in group ′B′ after the cessation of the respective treatments. Nevertheless, at present topical tacrolimus may be a valuable addition to the already existing therapeutic modalities for treating subjects with OLP.

  9. Retrospective analysis on 34 patients with oral submucous fibrosis coexisted with oral lichen planus%OSF并存OLP34例回顾性分析

    Institute of Scientific and Technical Information of China (English)

    李继佳; 彭解英; 吴颖芳; 孟庆玉; 谢迪; 李敏; 肖璇

    2011-01-01

    Objective: To analyze the clinical feature of oral submucous fibrosis (OSF) coexisted with oral lichen planus(OLP) ,to improve the diagnosis and treatment of the disease. Method: The clinical data of 34 patients with OSF coexisted with OLP were retrospectively reviewed. Result: All 34 patients with OSF coexisted with OLP were mainly young and middle-aged male patients, and had the habit of eating spicy foods and betel quid chewing. Among that 29 patients (85.29 %) had the smoking habit, 27 patients (79.41 %) had the alcohol drinking habit. On OSF pathologic staging 28 patients (82.35 %) were in the early stage and 6 patients (17.65 %) were in the middle stage. OSF coexisted with OLP was mainly seen on the buccal and lingual mucosa.no patient had the erosive type of lesion and trismus. Although pain could be relieved after therapy, white striations or macules did not regressed and the disappeared filiform and fungiform papillas did not recovered. Conclusion: OSF coexisted with OLP is not a simple combination of them, but have the special characteristics. While diagnosising if possible, take two biopsies from two typical locations. During tretment and after it, patient has to give up smoking and betel quid chewing habit.%目的:总结口腔黏膜下纤维性变(OSF)并存口腔扁平苔藓(OLP)的临床特征,提高对该病的诊断和治疗水平.方法:对34例OSF并存OLP患者的临床资料进行回顾性分析.结果:34例OSF并存OLP患者表现为青壮年男性居多,均有进食刺激性食物和咀嚼槟榔史,29例(85.29%)有吸烟史,27例(79.41%)有饮酒史,28例(82.35 %)OSF的病理分期为早期,6例(17.65%)为中期,发病部位以颊部和舌部为主,所有患者均无糜烂和张口受限,治疗后疼痛症状缓解,但白色条纹或斑点始终未消退,己消失的丝状乳头、菌状乳头亦未见恢复.结论:OSF并存OLP并非两种疾病的简单叠加,而是具有其特异性的表现,必要时可行两个典型部位活检进行诊

  10. Four Diseases, Two Associations, One Patient: A Case of Frontal Fibrosing Alopecia, Lichen Planus Pigmentosus, Acne Rosacea, and Morbihan Disease.

    Science.gov (United States)

    Walker, Joanna L; Robinson-Bostom, Leslie; Landow, Shoshana

    2016-01-01

    A 77-year-old woman born in the Dominican Republic presented with fullness of the glabella and medial eyebrows for 1 year followed by alopecia of the lateral eyebrows and frontal hairline. She stated that although she had a high hairline at baseline, it had receded in the past year. She had also noted central scalp hair thinning that started 6 years earlier. She denied all styling practices that used traction or chemical processes, although she admitted to hair dye and blow dryer use. She reported "acne" in the central face for decades and darkening of the skin on the lateral face for several years. Her medical history included hypertension, hyperlipidemia, hypothyroidism, benign paroxysmal positional vertigo, and treated breast ductal hyperplasia. Her medications were metoprolol, amlodipine, aspirin, levothyroxine, omeprazole, pravastatin, and meclizine; she denied starting any new medications within the past 2 years. Her family history was notable for androgenic pattern alopecia in a brother and a high hairline in her father. Review of systems was negative except for knee arthralgias and seasonal allergic rhinitis.

  11. Clinical observation of therapeutic effect of Tacrolimus Ointment in the treatment of patients with erosive oral lichen planus%他克莫司软膏治疗糜烂型口腔扁平苔藓的效果观察

    Institute of Scientific and Technical Information of China (English)

    吕晓君

    2012-01-01

    Objective: To evaluate the efficacy of Tacrolimus Ointment in the treatment of patients with erosive oral lichen planus. Methods: 62 patients in our department of our hospital were divided into two groups (group A and B). Group A was treated with Tacrolimus Ointment and group B was treated with Halometasone Ointment, the time was 8 weeks in a randomized clinical trial. Results: After treatment of 2 months, in the group A and B, the efficacy rate was 90.3%, 64.5% respectively, and the relapse rate within 6 months after treatment was 9.1% and 60.0% respectively, there were significant differences in the two groups (all P<0.05). Conclusion: The results of the present work demonstrate that Tacrolimus Ointment is an effective therapy for oral lichen planus.%目的:观察他克莫司软膏局部用药治疗糜烂型口腔扁平苔藓的疗效.方法:选择2009年6月~2011年1月在我科就诊的患者共62例,将其随机分成A组(应用他克莫司软膏局部涂擦)和B组(应用卤米松乳膏局部涂擦),疗程8周.结果:用药2个月后,A组有效率为90.3%,B组有效率为64.5%;停药6个月后治疗组复发率为9.1%,对照组复发率为60.0%.两组比较差异均有统计学意义(均P<0.05).结论:他克莫司软膏局部涂抹治疗糜烂型口腔扁平苔藓具有良好的临床疗效.

  12. Expression and significance of oral lichen planus in MMP-2 and MMP-9%口腔扁平苔藓中MMP-2和MMP-9的表达及意义

    Institute of Scientific and Technical Information of China (English)

    浦光瑞; 张虹

    2012-01-01

    [目的]探索MMP -2和MMP -9与口腔扁平苔藓(oral lichen planus,OLP)的发生、发展乃至癌变潜能的关系.[方法]采用免疫组化SP法检测MMP -2和MMP -9在22例OLP、11例正常口腔黏膜组织、22例白斑和22例口腔鳞癌组织表达.[结果]在正常口腔黏膜、扁平苔藓、白斑和鳞癌组织中MMP -2和MMP -9的表达依次增加.MMP -2和MMP -9在口腔扁平苔藓和白斑中的表达显著高于正常口腔黏膜(P<0.05),但在口腔扁平苔藓和白斑间的表达差异无显著性意义(P>0.05);在鳞癌中的表达显著高于其他3组(P<0.05).[结论] MMP -2和MMP -9表达与OLP的发生、发展乃至癌变潜能有关.%To Explore the relationshiops of MMP -2 and MMP -9 to the OLP occurrence, the development and even the canceration potential. [Methods] Immunohisto ?chemistry was performed to examine expressions of MMP -2 and MMP -9 in 22 OLP, 11 normal oral mucosa, 22 oral leukoplakia and 22 squamous cell carcinoma. [Results] The expression of MMP -2 and MMP -9 increased in turn from normal oral mucosa to OLP, oral leukoplakia and oral squamous cell carcinoma tissues. The expression of MMP -2 and MMP -9 in OLP and oral leukoplakia was significantly higher than that in normal oral mucosa ( P 0. 05) ; The expression of MMP - 2 and MMP - 9 in squamous cell carcinoma was significantly higher than The other three groups (P < 0. 05 ) , there was significant difference. [ Conclusion ] The expression levels of MMP - 2 and MMP - 9 correlate with the occurrence of oral lichen planus, development and e-ven cancer potential, which may be useful indicator to judge the possibility of malignant change of OLP.

  13. Treatment of Ulterate-lichen Planus by PA and Iodine Glycerin%醋酸强的松龙和碘甘油治疗糜烂型扁平苔癣

    Institute of Scientific and Technical Information of China (English)

    许云

    2004-01-01

    目的探讨糜烂型扁平苔癣(Ulterate-lichen planus,ULP)的治疗方法.方法应用醋酸强的松龙(Prednisolone Acetate,PA)病变区内注射和碘甘油(iodine glycerin)局部外用治疗糜烂型扁平苔癣38例,并进行疗效观察.结果38例糜烂型扁平苔癣病人中的25例糜烂面消失,8例好转,5例无变化.总有效率86%.结论短疗程醋酸强的松龙和碘甘油联合应用治疗糜烂型扁平苔癣治疗方法是安全有效的.近期疗效肯定,远期疗效有待进一步观察.

  14. 扁平苔藓中早期生长反应因子-1和肿瘤坏死因子-α的表达及意义%Expression and significance of early growth response-1 and tumor necrosis factor-α in lichen planus

    Institute of Scientific and Technical Information of China (English)

    邓磷君; 白莉

    2012-01-01

    目的:探讨早期生长反应因子-1(Egr-1)和肿瘤坏死因子-α(TNF-α)在扁平苔藓发病中的作用.方法:采用TUNEL原位凋亡检测法检测30例扁平苔藓皮损及30例正常皮肤组织中细胞凋亡情况,并用免疫组织化学法检测该30例扁平苔藓和30例正常皮肤组织中Egr-1和TNF-α的表达情况.结果:扁平苔藓皮损处角质形成细胞和真皮浅层浸润的淋巴细胞中细胞凋亡水平明显高于对照组;在相同部位,Egr-1和TNF-α的表达水平高于正常皮肤组织,差异有统计学意义(P<0.05),且二者在扁平苔藓皮损处的表达呈正相关(r=0.896 7,P<0.05).结论:Egr-1和TNF-α的高表达可能参与了扁平苔藓的发病.%Objective: To investigate the effect of Egr-1 (early growth response-1) and TNF-a (tumor necrosis factor-a) on the pathogenesis of lichen planus. Methods: TLJNEL was used to detect the apoptotic cells, and the immunchistochemi-cal technique was used to test the expression of Egr-1 and TNF-a in 30 LP lesions and 30 normal skins. Results: Compared with the control group, the number of apoptotic cells was significantly increased in the ketatinocytes and infiltrating lymphocytes of lichen planus. In the same site, the expression of Egr -1 and TNF -a in lichen planus was significantly stronger than that in the normal skins (P<0.05), and there were positive correlations between the expression of Egr-1 and TNF-a in LP lesions(n=0.896 7, P<0.05). Conclusion: Egr-1 and TNF-a may participate in the pathogenesis of lichen planus.

  15. Expression of cellular FLICE-inhibitory protein in peripheral blood and lesion of patients with lichen planus%凋亡抑制蛋白c-FLIP在扁平苔癣患者外周血淋巴细胞和皮损中的表达

    Institute of Scientific and Technical Information of China (English)

    化红霞

    2009-01-01

    Objective To investigate the expression and distribution of cellular FLICE( Fas-assoelated death domain-like interleukin-I β-converting enzyme-like)-inhibitory protein (c-FLIP) in peripheral blood and lesions of lichen planus patients. Methods Peripheral blood and skin samples were obtained from 30 patients with lichen planns and 20 normal controls. Flow cytometry was used to detect intracellular c-Fl,lP in peripheral T and B lymphocytes, and immunohistochemistry was used to examine the expression of c-FLIP in lesionai tissue. Results Based on the pesitivity rate of c-FLIP, there was a significant increase in T iymphocytes in lichen planus compared with normal controls(6.32%±1. 17% vs 2.28%±0.54%, P 0. 05 ). The expression intensity of c-FLIP in keratinocytes was also higher in lichen planusthanthatinnormalcontrols ( 89.73%± 5.24% vs 121.58% ±7.93% ,P 0.05).c-FLTP蛋白在扁平苔癣患者皮损中的表达(89.73%±5.24%)明显高于正常人对照组(121.58%±7.93%),P<0.01.结论 凋亡抑制蛋白c-FLIP在扁平苔癣患者的外周血T细胞和皮损内明显高表达,可能参与扁平苔癣患者T细胞的增殖.

  16. Association study of interleukin 12A gene polymorphisms with oral lichen planus%白介素12A基因多态性与OLP的相关性研究木

    Institute of Scientific and Technical Information of China (English)

    江晨艳; 姚辉; 唐国瑶

    2011-01-01

    Objective:To investigate single nucleotide polymorphisms (SNP) of interleukin 12A gene with oral lichen planus (OLP) in Chinese Hans residing in East and South-east China, and to provide an important genetic basis in exploring the disease susceptibility and diverse clinical manifestation.Method:Two hundred and ninety-two patients with OLP and 686 healthy control subjects were recruited in Chinese Hans residing in East and South-east China.Genomic DNA was extracted and PC R products spanning five SNPs of the IL-12A gene at positions (rs3024415, rs2243123, rs583911, rs568408 and rs2243143) were analyzed.The genotype frequencies were calculated and analyzed.Result: ①Polymorphism of rs568408, located at the 3'-UTR region was found to have a significant association with OLP (P =0.0427).②Polymorphism of rs583911 was also found to have a significant association with OLP (P =0.0085).③The allele frequencies of IL-12A-rs568408 / A in the erosive OLP group were much higher than that in the healthy group (OR=1.76,95 % CI 1.133-2.732, P =0.011).Conclusion:The variation of IL-12A rs568408 gene polymorphisms seems to have some influence on the disease susceptibility and association with the severity of OLP in this Chinese cohort residing in East and South-east China.%目的:研究华东地区汉族人群 IL-12A 基因多态性与口腔扁平苔藓(oral lichen planus,OLP)的相关性.方法:采用 TaqMan 荧光定量 PCR 法检测华东地区 292 例 OLP 患者及 686 例正常对照者的 IL-12A 基因的 5 个 SNP 位点(rs3024415,rs2243123,rs583911,rs568408 和 rs2243143),分析 IL-12A 基因多态性与 OLP 的相关性.结果:①华东地区健康人群 IL-12A 基因 3-UTRrs568408 位点 AA、GA 和 GG 基因型频率分别是 0.7%、12.4%和 86.8%,而 OLP 患者分别是 1.1%、18.4%和 80.5%,其中 GA 和 AA 基因型分布频率显著高于正常对照组(P=0.0427).②正常对照组IL-12A 基因 rs583911 位点 AA、GA 和 GG 基因型频率分别是 4.2%、38.6%

  17. A randomized triple-blind clinical trial to compare the effectiveness of topical triamcinolone acetonate (0.1%), clobetasol propionate (0.05%), and tacrolimus orabase (0.03%) in the management of oral lichen planus

    Science.gov (United States)

    Sivaraman, Shivakumar; Santham, Krishnamoorthy; Nelson, Aruldoss; Laliytha, Bijaykumar; Azhalvel, Pandian; Deepak, John Hearty

    2016-01-01

    Background: Oral lichen planus (OLP) is believed to result from an abnormal T-cell mediated immune response. The most useful agent in the treatment is corticosteroids. The present study will be aimed at evaluation of therapeutic efficiency of two corticosteroids triamcinolone acetonate (0.1%) and clobetasol propionate with tacrolimus orabase (0.03%), an immunomodulator in the management of OLP. Aim: To compare the effectiveness of topical triamcinolone acetonate (0.1%), clobetasol propionate (0.05%), and tacrolimus orabase (0.03%) in the management of OLP and also to compare which has less recurrence. Study Design: The study comprises 30 patients, all were diagnosed with OLP clinically and histopathologically. They are randomly divided into three groups: Group A - triamcinolone acetonate (0.1%), Group B - clobetasol propionate (0.05%), and Group C - tacrolimus (0.03%). A formal informed consent was obtained from all of them who participated in the study. Results and Conclusion: Subjects in the Group A (triamcinolone 0.1%) and Group B (clobetasol 0.05%) show a significant reduction in lesion size than that of Group C (tacrolimus 0.03%). Group B (clobetasol 0.05%) shows a better significant reduction in lesion size than that of Group A (triamcinolone 0.1%). The overall treatment response was significant better in the Group B (clobetasol 0.05%). No recurrence was observed in any of the three groups at the end of 3 months. It is concluded that clobetasol propionate 0.05% ointment has higher efficacy when compared to triamcinolone acetonide 0.1% ointment and tacrolimus ointment 0.03% in the management of OLP. It was also inferred that triamcinolone 0.1% has better effects than tacrolimus 0.03%. PMID:27829754

  18. 口腔黏膜扁平苔藓癌变的诊断与综合治疗%The diagnosis and comprehensive treatment of oral lichen planus canceration

    Institute of Scientific and Technical Information of China (English)

    叶茂昌; 马骏; 王来平; 李容新; 李黎丽; 曹浩

    2011-01-01

    PURPOSE: To discuss the diagnosis and comprehensive treatment based on operation and close observation of canceration of oral lichen planus (OLP). METHODS: Sixty -four patients with cancerous OLP were retrospectively analyzed, who were clinically diagnosed and pathologically confirmed to be OLP canceration from 1998 to 2007. Only patients who had buccal mucosal lesions were selected. After 21 days of PVP induction chemotherapy, all the patients underwent radical resection. RESULTS: The 1- and 3-year survival rate was 87.50% and 75.00%, respectively; regional recurrences occurred in 11 patients (17.18%). CONCLUSIONS: A criteria of OLP canceration was established, which solved the disagreement with OLP canceration by Krutchkoff et al; treatment of OLP canceration should be comprehensive.%目的:探讨口腔黏膜扁平苔藓(OLP)癌变的诊断和以手术为主的综合治疗的效果.方法:对1998-2007年间收治的经临床初诊并经病理学证实的64例OLP癌变患者,从临床角度进行回顾性分析.为便于观察,均选择位于颊黏膜的患者,在PVP诱导化疗21d后选择根治性手术.结果:术后1、3年的生存率分别为87.50%和75.00%,局部复发11例(17.18%).结论:探讨OLP癌变的诊断标准,解决了Krutchkoff等提出的不同意OLP癌变的3点质疑;OLP癌变治疗的重点在于综合治疗.

  19. A case of multiple lichen planus-like keratoses with junctional melanocytic proliferation%多发性扁平苔藓样角化症伴交界区黑素细胞增生一例

    Institute of Scientific and Technical Information of China (English)

    关杨; 陶小华; 张芸; 莫衍石

    2011-01-01

    报告1例多发性扁平苔藓样角化症伴交界区黑素细胞增生.患者男,83岁.四肢紫红色扁平丘疹、斑块逐渐增多1年,无服药史.组织病理检查显示,表皮角化过度伴角化不全,棘层肥厚,可见坏死的角质形成细胞,基底细胞灶性液化,真皮浅层带状淋巴细胞及少数浆细胞和嗜酸粒细胞浸润,皮损边缘可见日光性黑子样改变.免疫组化染色,苔藓样浸润处Mela-A阳性黑素细胞明显增多,细胞体积大呈星状.%A case of multiple lichen planus-like keratoses with junctional melanocytic proliferation is reported.An 83-year-old male patient complained of multiple purple red flat papules and plaques on the extremities for 1 year with no medication history.Histopathology examination showed epidermal hyperkeratosis,focal parakeratosis, acanthosis, necrosis of keratinocytes, focal liquefaction of basal cells, bandlike infiltration of lymphocytes, eosinophils and few plasma cells in superficial dernis.Solar lentigo-like pathological changes were observed at the edge of the lesions.Immunohistochemical study revealed an obvious increase in the count of large, star-shaped, Mela-A-positive melanocytes in the lichenoid infiltrates.

  20. The Genotypic Profiles of Candida albicans Isolates from Patients with Oral Lichen Planus%口腔扁平苔藓患者白色念珠菌分离株的基因型分析

    Institute of Scientific and Technical Information of China (English)

    曾昕; 陈谦明; 聂敏海; 李秉琦

    2005-01-01

    目的研究健康人和口腔扁平苔藓(oral lichen planus,OLP)患者口腔白色念珠菌分离株的基因型分布特征.方法应用随机扩增片段多态性分析法(randomly amplified polymorphic DNA,RAPD),对来自于健康人(26株)、糜烂型OLP患者(62株)以及非糜烂型OLP患者(24株)共112株白色念珠菌菌株做基因型分型,比较OLP患者与健康对照组白色念珠菌分离株的基因型分布差异.结果本研究采用的RAPD分析法可大致将所有白色念珠菌分离株分为A、B、C、D四种基因型;健康对照组、糜烂型OLP和非糜烂型OLP患者组的白色念珠菌分离株的基因型构成具有差异,其中,健康对照组以B、D型为主,糜烂型OLP患者组以A、C型为主,非糜烂型OLP患者组以A、D型为主.结论某些具有特定基因型的白色念珠菌与OLP的发生发展可能相关.

  1. Análise histopatológica comparativa entre líquen plano oral e cutâneo Comparative histopathological analysis between oral and cutaneous lichen planus

    Directory of Open Access Journals (Sweden)

    Silvia Elena Navas-Alfaro

    2003-01-01

    ência rara no LPO. Acantose em dente de serra é achado pouco freqüente no LPO, porém vacuolização basal está sempre presente associada a infiltrado linfocitário em faixa; plasmócitos podem acompanhar linfócitos no LPO, mas estão ausentes do LPC.BACKGROUND: Lichen planus is a relatively common chronic inflammatory disease affecting skin and mucous membranes, separately or together. It frequently involves the oral cavity, with or without concomitant cutaneous compromise. Microscopically, while skin presents well characteristic aspects, oral mucosa can present variations related to local characteristics of the mucosa in the oral cavity. OBJECTIVES: To compare histopathological alterations of oral lichen planus and cutaneous lichen planus with the study of the inflammatory infiltrate components. METHODS: 59 biopsies (29 of OLP and 30 of CLP, formalin-fixed, paraffin-embedded were studied. Semi-quantitative analysis of both epidermal and dermal alterations was performed using the hematoxylin-eosin and periodic acid-Schiff stains. RESULTS: For CLP the classic aspects of orthokeratosis, wedge shaped hypergranulosis and saw tooth rete ridges were observed. Such aspects differ from those of OLP in which orthokeratosis and thickened granular layer happen less frequently; instead, acquisition of those layers is observed in places where they are usually absent. Basal cell vacuolar alteration and effacement of the epithelium-conjunctive limit prevailed in both locations (skin and oral mucosa and lymphocytes and histiocytes were the inflammatory cells present in all cases. CONCLUSIONS: Classic alterations as compact orthokeratosis, wedge shaped hypergranulosis, saw tooth rete ridges acanthosis and basal cell vacuolar alteration associates to lymphocytes in superficial band-like pattern are diagnostic of CLP. However, for OLP, the particular own characteristics of oral mucosa in the biopsied place should be considered; also, subtler alterations of horny (light orthokeratosis and

  2. Analysis of advantages and disadvantages of topical tacrolimus in treatment of erosive oral li-chen planus%他克莫司软膏治疗顽固性糜烂型口腔扁平苔藓的利弊分析

    Institute of Scientific and Technical Information of China (English)

    王翔剑; 周红梅

    2014-01-01

    口腔扁平苔藓( oral lichen planus ,OLP)是一种常见的口腔黏膜慢性炎性疾病,部分糜烂型OLP对糖皮质激素治疗不敏感甚至无效。他克莫司软膏是一种免疫抑制类局部制剂,学者们用于治疗顽固性糜烂型OLP取得一定疗效,但同时也发现一些值得注意的问题。本文对他克莫司软膏用于治疗顽固性糜烂型OLP的利弊进行分析,为临床医师更合理地应用该类制剂提供参考。%Oral lichen planus ( OLP) is a common chronic inflammatory disease of the oral mucosa .Some of erosive OLP pa-tients show resistance or even invalidity to glucocorticoid therapy .As a topical immunosuppressive agent ,tacrolimus ointment treatment of intractable erosive OLP has been demonstrated to have some effective ,but scholars also identified some notable problems .In this pa-per,the pros and cons of topical tacrolimus treatment of erosive OLP will be analyzed .It could provide a reference to clinicians for a more rational application of such formulations .

  3. 基质金属蛋白酶在口腔扁平苔藓、白斑及鳞癌中的研究进展%Research progress on Matrix Metalloproteinases in oral Lichen Planus,oral leukoplakia and oral squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    浦光瑞; 张虹

    2013-01-01

    Matrix metalloproteinases are necessary for the degradation of extracellular matrix protease family and play an important role in the synthesis and degradation of extracelluar matrix. The role of MMPs can be specific inhibited by Tissue Inhibitor of metalloproteinases. Under normal physiological conditions, MMPs and TIMP cooperative productions maintain dynamic balance, but when this balance is broken, the metabolism of basement membrane and extracelluar matrix are abnormal and lead to various diseases and promote disease progression. Now the relationships of MMPs and TIMPs with oral lichen planus and other oral disease are reviewed in this article.%基质金属蛋白酶(matrix metalloproteinases,MMPs)是细胞外基质降解所必需的蛋白酶家族,在基质成分的合成和降解过程中起着重要作用.MMPs的作用可被其抑制剂(tissue Inhibitor of metalloproteinases,TIMPs)特异性抑制,在正常生理状态下,MMPs与TIMP协同产生,维持动态平衡,但当这种平衡被打破时基底膜和细胞外基质(extracelluar matix,ECM)的代谢发生异常,导致各种疾病并促进疾病恶化.现将MMPs和TIMPs与口腔扁平苔藓(oral lichen planus,OLP)及其他口腔疾病的关系作如下综述.

  4. Research Progress of Etiology and Pathogenesis of Lichen Planus%扁平苔藓病因及发病机制的研究进展

    Institute of Scientific and Technical Information of China (English)

    通拉嘎; 庞传超; 张玉荣

    2011-01-01

    Objective:To summarize research progress of etiology and pathogenesis of lichen planus(LP) at home and abroad.Methods:Application of PUBMED retrieval system and CHKD journal full-text database system,we research the relevant literatures in the past 10 years with "etiology of lichen planus" as keywords Cell-mediated immune response,marker molecule change in cell differentiation,virus infection,neuropsychiatric factors and keratinocytes apoptosis are closely related with the incidence of LP.Conclution:The causes of LP is complex,recent research suggests that apoptosis is related with the pathogenesis of LP,which worth further study%目的:总结国内外对扁平苔藓病因及发病机制的研究进展.方法:应用检索PUBMED及CHKD期刊全文数据库检索系统,以"扁平苔藓病因"为关键词,检索近10年有关文献.结果:细胞介导的免疫反应,细胞分化标志分子的改变,病毒感染,神经精神因素及角质形成细胞的凋亡与扁平苔藓发病关系密切.结论:扁平苔藓病因复杂,最新研究提示其发病机制与细胞凋亡有关,值得我们进一步研究探讨.

  5. Expression of IL-36 and p38MAPK pathway and Th17 cytokine in lichen planus%IL-36γ、p38 MAP K通路和 Th17细胞因子在扁平苔藓中的表达

    Institute of Scientific and Technical Information of China (English)

    贺琪; 吴艳; 岳青; 李家文

    2014-01-01

    目的:检测IL-36及p38丝裂原活化蛋白激酶( p38MAPK)通路和Th17细胞因子在扁平苔藓中的表达。方法:应用Envision免疫组化法检测58例扁平苔藓及19名正常皮肤标本中IL-36γ、磷酸化-p38MAPK( p-p38)和IL-17A的表达。结果: IL-36γ、p-p38和IL-17A在扁平苔藓皮损中的蛋白表达阳性率为86.21%、79.31%和94.83%,显著高于正常对照标本阳性率为68.42%、15.79%和63.16%(均P<0.01)。扁平苔藓组中,IL-36γ与p-p38、IL-36γ与IL-17A的表达水平存在显著正相关(P<0.001),两因子表达强度有显著差异(P<0.05)。结论: p38MAPK通路和Th17细胞因子可能与扁平苔藓的发病有关。%Objective:To detect the expression of IL-36, p38 mitogen-activated protein kinase ( p-p38) pathway and Th17 cytokine in lichen planus. Methods:Immunohistochemistry EnVision technique was used to detect the expression of IL-36γ, p-p38 and IL-17A in 58 patients with lichen planus and 19 controls. Re-sults:The expression of IL-36γ, p-p38 and IL-17A was higher in the patients’ lesion of lichen planus ( the positive rates were 86.21%, 79.31% and 94.83%) than in control group (the positive rates were 68.42%, 15.79% and 63.16%) ( all P<0.01) . In lichen planus group, there were positive correlations between the ex-pression of IL-36γand p-p38 ( P<0.001) , and between the expression of IL-36γand IL-17A ( P<0.001) . Significant difference was also observed between the two cytokines’ expression grade ( P<0.05) . Conclusion:p38MAPK pathway and Th17 cytokine may be involved in the pathogenesis of lichen planus.

  6. Oral lichen planus update:clinical mendcine treatment%口腔扁平苔藓临床药物治疗进展

    Institute of Scientific and Technical Information of China (English)

    汪群; 孙红英

    2006-01-01

    口腔扁平苔藓(oral lichen planus,OLP)是发生于口腔的一种常见的慢性炎性免疫反应性疾病,多数学者认为口腔扁平苔藓为T淋巴细胞介导的免疫相关疾病,世界卫生组织将其列为可能的癌前病变。由于治疗口腔扁平苔藓的药物繁多,用法途径不一,加之新药物层出不穷,国内外尚无系统的文献综述,本文对近5年来国内外报道的有关OLP的新药物(如:莫米松糠酸酯,维生素A)及传统经典药物的治疗方法和疗效进行综述,以期为正确治疗OLP提供药物信息和临床治疗指导。

  7. A preliminary study on the correlation between the Helicobacter pylori infection and oral lichen planus and squamous cell carcinoma%幽门螺杆菌感染与口腔扁平苔藓和鳞状细胞癌相关性的初步探讨

    Institute of Scientific and Technical Information of China (English)

    姚小武; 林敏校; 陈仕生; 卢子正

    2014-01-01

    目的研究正常口腔黏膜、口腔扁平苔藓(OLP)和口腔鳞状细胞癌(OSCC)中幽门螺杆菌(H.pylori)感染情况及其与p53蛋白和p16蛋白表达的关系,探讨H.pylori感染与OLP和OSCC的相关性。方法 OLP标本23例、OSCC标本50例和正常口腔黏膜标本10例,采用免疫组化SP法检测其H.pylori的感染、p53蛋白、p16蛋白的表达,应用SPSS 13.0软件包对结果进行卡方分析检验,单因素方差分析和线性回归检验分析。结果正常口腔黏膜组织组、OLP组及OSCC组中H.pylori阳性率分别为0、47.8%和48.0%,正常口腔黏膜组与OLP组和OSCC组间差异有统计学意义(χ2=7.17,P=0.013;χ2=8.00,P=0.004);OLP标本中 H.pylori 阳性组和阴性组 p53蛋白表达率分别为45.5%和16.7%,p16蛋白表达率为分别36.4%和66.7%,组间差异有统计学意义(χ2=3.86,P=0.043;χ2=3.89,P=0.048);OSCC标本中H.pylori阳性组和阴性组p53蛋白表达率分别为91.7%和84.6%,p16蛋白表达率为分别20.8%和30.8%,组间差异无统计学意义(χ2=0.58,P=0.669;χ2=0.65,P=0.526)。结论 H.pylori感染与OLP和OSCC存在一定的相关性,H.pylori感染在OLP和OSCC发生、发展中的作用有待于进一步研究。%Objective To investigate the correlation between the Helicobacter pylori (H.pylori) infection and oral lichen planus (OLP) and squamous cell carcinoma (OSCC), the H.pylori infection, expressions of p53 and p16 in the normal oral mucosa , oral lichen planus and squamous cell carcinoma were detected. Methods Twenty-three oral lichen planus, 50 squamous cell carcinoma and 10 normal oral mucosa were tested. The H.pylori infection and the expressions of p53 and p16 were detected by immunohistochemical technique (SP method). The data was analyzed by Fisher′s Exact Test, one-way ANOVA and linear regression analysis using SPSS 13.0 software package. Results The rate of H.pylori infection in normal

  8. Clinical efficacy of basic periodontal therapy combined with local medication for erosive oral lichen planus%牙周基础治疗联合局部药物治疗对糜烂型口腔扁平苔藓的临床效果观察

    Institute of Scientific and Technical Information of China (English)

    李娟; 黄婷; 薛雯; 李海燕

    2016-01-01

    Objective To study the clinical efficacy of basic periodontal therapy combined with local medication for erosive oral lichen planus ( OLP) . Methods 56 patients with erosive oral lichen planus and periodontitis were randomly divided into two groups: experimental group and control group. Experimental group received basic periodontal therapy and drug therapy. Control group received drug therapy only. For all patients, the clinical symptoms of OLP were examined at baseline, one month after therapy and six month after therapy. Results One month after therapy, there was significant difference in the clinical effects of treatments between experimental group ( 92. 86%) and control group ( 67. 86%) ( P<0. 05) . Six month after therapy, there was significant difference in the clinical effects of treatments between experimental group ( 85. 71%) and control group ( 57. 14%) ( P<0. 05) . Conclusion Basic periodontal therapy can effectively re-lieve the clinical symptom of OLP in erosiveoral lichen planus patients with chronic periodontitis, indicating that periodon-tal intervention has positive therapeutic effect.%目的:研究牙周基础治疗联合局部药物封闭对糜烂型口腔扁平苔藓患者的临床疗效。方法选取糜烂型口腔扁平苔藓伴慢性牙周炎患者56例,随机分为2组,试验组采用牙周基础治疗联合局部药物治疗,对照组仅采用局部药物治疗,观察治疗后1个月及6个月2组患者口腔扁平苔藓临床症状的改善。结果治疗后1个月试验组和对照组的有效率为92.86%和67.86%,试验组高于对照组(χ2=5.54,P<0.05);治疗后6个月,试验组和对照组的有效率分别为85.71%和57.14%,试验组高于对照组(χ2=5.60,P<0.05)。结论牙周基础治疗有助于改善糜烂型口腔扁平苔藓患者的黏膜病损,提高疗效。

  9. Expression of Fas and Fas ligand in infiltrating lymphocytes in patients with oral lichen planus%口腔扁平苔藓固有层淋巴细胞中Fas及Fas配体的表达变化

    Institute of Scientific and Technical Information of China (English)

    雷蕾; 谭为霞; 周序珑; 郑佩娥

    2010-01-01

    目的 检测Fas及Fas配体(Fas ligand,FasL)在口腔扁平苔藓(oral lichen planus,OLP)固有层淋巴细胞中的蛋白表达,探讨Fas、FasL和活化诱导的细胞死亡(activation-induced cell death,AICD)与OLP发病的关系.方法 采用脱氧核糖核苷酸末端转移酶介导的原位缺口末端标记法检测31例OLP和10例正常口腔黏膜(normal oral mucosa,NOM)中淋巴细胞凋亡情况;分别使用免疫组化法检测组织总淋巴细胞及CD8~+、CD4~+T细胞Fas、FasL的表达.结果 OLP与NOM固有层淋巴细胞凋亡率[分别为(1.9±1.8)%、(11.5±9.0)%]差异有统计学意义(P=0.013).OLP淋巴细胞Fas、FasL表达与NOM组相比明显增强[阳性表达率分别为52%(16/31)、71%(22/31),P值分别为0.005、0.000].OLP中CD8~+与Fas~+细胞双阳性表达率为10%,与NOM组相比无明显升高(P=0.313),而CD8~+与FasL~+细胞双阳性表达率[58%(3/31)]显著升高(P=0.002).CD4~+与Fas~+细胞双阳性表达率为35%(11/31),较NOM组显著升高(P=0.031),其中网纹型的表达明显升高(阳性表达为8/19,P=0.019),但糜烂、萎缩型的表达无显著升高(阳性表达为3/12,P=0.097).CD4~+与FasL~+表达率为16%(5/31),与NOM组相比无明显增强(P=0.182).结论 OLP淋巴细胞凋亡低下;OLP中T细胞亚群Fas、FasL表达不均衡,CD8~+细胞和萎缩、糜烂型OLP中CD4~+细胞可能逃逸AICD,与炎症的持续和进展有关;网纹型OLP中部分CD4~+T细胞可能经历AICD.%Objective To examine the expression of Fas and Fas ligand(FasL)in T lymphocytes of oral lichen planus(OLP)and the effects of Fas,FasL and activation-induced cell death(AICD)on OLP.Methods The oral mucosa samples from patients with OLP and nomal oral mucosa were assessed by in situ terminal deoxynucleotidyl transferase(TdT)-mediated deoxvuridine-5'-triphosphate(dUTP)-biotin nick endlabelling(TUNEL)assay for nucleosomal DNA fragmentation of apoptotic cells in infiltrating lymphocytes.Immunohistochemcial technique was used for detection of

  10. Expression and significance of FOXP3 in pityriasis rosea, lichen planus, large-plaque parapsoriasis and mycosis fungoides%FOXP3在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    周秉侠; 郭淑兰; 许艳静

    2012-01-01

    Objective To investigate expression and significance of fork-head box protein-3 (FOXP3) in normal skins, pityriasis rosea, lichen planus, large-plaque parapsoriasis, and mycosis fungoides. Methods The immunohistochemi-cal EnVision method was applied to detect expression of FOXP3 in 21 cases of pityriasis rosea, 19 cases of lichen planus , 17 cases of large-plaque parapsoriasis, 22 cases of mycosis fungoides, and 10 normal skin controls. Results Rates of FOXP3 -positive lymphocytes in lesions of pityriasis rosea and lichen planus had no significant difference compared with normal skin (P >0.05). Rates of FOXP3-positive lymphocytes in lesions of large-plaque parapsoriasis and mycosis fungoides were higher than those in pityriasis rosea, lichen planus, and normal skin(P 0. 05). Conclusions FOXP3-positive lymphocytes show a gradual increasing tendency in inflammatory skin diseases, tumor tendency inflammatory skin diseases and cutaneous lymphoma. They may play an important role in immune escape of tumors and promote tumor occurrence and development.%目的 探讨叉头状转录因子P3( FOXP3)在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义.方法 采用免疫组织化学EnVision法检测21例玫瑰糠疹、19例扁平苔藓、17例大斑块型副银屑病、22例蕈样肉芽肿及10例正常人皮肤中FOXP3的表达.结果 玫瑰糠疹、扁平苔藓皮损中FOXP3+淋巴细胞阳性率与正常人皮肤中的表达差异无统计学意义(P>0.05);大斑块型副银屑病与蕈样肉芽肿皮损中FOXP3+淋巴细胞阳性率均高于玫瑰糠疹、扁平苔藓及正常皮肤(P<0.05),但其二者之间的表达差异无统计学意义(P>0.05).结论 FOXP3+淋巴细胞阳性率在炎症性皮肤病、有肿瘤发展倾向的炎症性皮肤病及皮肤淋巴瘤中的表达有逐步增高的趋势.其增多可能为肿瘤细胞的免疫逃逸提供了条件,进而促进了肿瘤的发生、发展.

  11. Clinical test of serum treponema pallidum and human immunodeficiency virus in patients with oral lichen planus%口腔扁平苔藓患者血清梅毒螺旋体、人类免疫缺陷病毒感染的检测

    Institute of Scientific and Technical Information of China (English)

    刘铁军; 史婷婷; 刘健; 张雨温; 许彦枝

    2016-01-01

    目的 探讨梅毒螺旋体(treponema pallidum,TP)、人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染对口腔扁平苔藓(oral lichen planus,OLP)发病的影响.方法 采用全自动化学发光免疫分析技术检测OLP组(n=100)与正常对照组(n=60)血清TP、HIV抗体的表达.结果 2组TP-IgG抗体、HW-IgG抗体表达率差异无统计学意义(P>0.05).结论 TP、HIV感染对OLP发病无明显影响.

  12. A study on the curative effects of hydroxychloroquine sulphate combined with tacrolimus in the treatment of oral lichen planus%硫酸羟氯喹联合他克莫司治疗口腔扁平苔藓的疗效研究

    Institute of Scientific and Technical Information of China (English)

    冯炼; 李仲贤; 刘宇

    2015-01-01

    目的:观察传统免疫抑制剂(硫酸羟氯喹)联合他克莫司治疗口腔扁平苔藓的短期疗效和安全性。方法80例口腔扁平苔藓患者分为两组,实验组给予0.0015%他克莫司溶液每日2次含服及口服硫酸羟氯喹片100 mg,每日1次,对照组予口服硫酸羟氯喹片100 mg,每日1次,治疗观察4周,治疗结束时评价有效率和不良反应发生率。结果实验组治疗有效率为95.0%,对照组治疗有效率为35.0%,硫酸羟氯喹联合他克莫司对口腔扁平苔藓的短期疗效明显优于硫酸羟氯喹(字2=31.65,P=0.00),但两组不良反应率无明显差异。结论硫酸羟氯喹联合他克莫司对口腔扁平苔藓的短期疗效明显优于硫酸羟氯喹,安全有效,值得临床推广应用。%Objective To observe the short-term curative effects and safety of conventional immunosuppressor (hydrox-ychloroquine sulphate) combined with tacrolimus in the treatment of oral lichen planus. Methods Eighty patients with oral lichen planus were assigned to two groups. The experiment group was sublingually given 0.0015%of tacrolimus so-lution twice a day, and was orally given 100 mg of hydroxychloroquine sulphate tablets once a day. The control group was orally given 100 mg of hydroxychloroquine sulphate tablets once a day. The treatment was observed for 4 weeks, and the effective rate and incidence of adverse effects at the end of the treatment were evaluated. Results The effective rate of experiment group was 95.0%, and the control group was 35.0%. The short-term curative effect of hydroxychloro-quine sulphate combined with tacrolimus in the treatment of oral lichen planus was significantly better than that of hydroxychloroquine sulphate alone (χ²=31.65, P=0.00), but the incidence of adverse had not significantly different be-tween two groups. Conclusion The short-term curative effect of hydroxychloroquine sulphate combined with tacrolimus in the treatment of oral lichen planus is significantly

  13. 康复新液治疗糜烂型口腔扁平苔藓的近期疗效观察%Short-term effects of kangfuxin solution on treatment of erosive oral lichen planns

    Institute of Scientific and Technical Information of China (English)

    赵玉萍

    2009-01-01

    目的 观察康复新液治疗糜烂型口腔扁平苔藓(OLP)的近期疗效,探寻治疗糜烂型OLP的有效方法.方法 将糜烂型OLP 50例随机分成两组.试验组25例采用康复新液治疗,对照组25例采用西瓜霜喷剂治疗,治疗前及治疗后1周分别观察疼痛程度和糜烂面积的变化.结果 同对照组比较,试验组疼痛程度减轻,糜烂面积缩小,近期疗效具有显著性差异(P<0.01).结论 康复新液治疗糜烂型OLP安全有效,且疗效优于西瓜霜喷剂,值得临床推广使用.%Objective To evaluate the short-term effects of kangfuxin solution on the treatment of erosive oral lichen planus and try to find out an effective way to treat the erosive oral lichen planus. Methods 50 patients with erosive oral lichen planus were divided into two groups randomly. The test group (25 cases) were treated with kangfuxin solution; the control sroup (25 cases) were treated with watermelon powder spray. Clinical examinations evaluated the pain and the erosive area before treatment and after treatment for one week. Results Pain was lessened and the erosive area was decreased, compared with the control group, which had significant difference (P < 0. 01). Conclusions The treatment of erosive oral lichen planus with kangfuxin solution is safe and effective. Its cur-ative effects are better than those of watermelon powder spray. It' s worthy to be recommended for clinical application.

  14. Case Report of Lichen Planopilaris Occurring in a Pediatric Patient Receiving a Tumor Necrosis Factor α Inhibitor and a Review of the Literature.

    Science.gov (United States)

    Jayasekera, Prativa S A; Walsh, Maeve L; Hurrell, Daniel; Parslew, Richard A G

    2016-01-01

    A 12-year-old girl with extended oligoarthritis treated with adalimumab presented with a short history of a progressive cutaneous eruption involving the legs and scalp. Physical examination and histologic results were consistent with lichen planopilaris. The adalimumab was discontinued. She received treatment with topical clobetasol propionate and the majority of the lesions resolved. Residual lesions and the extended oligoarthritis were then treated with sulfasalazine. Adalimumab is a tumor necrosis factor α (TNF-α) inhibitor used for the treatment of a variety of immunologically mediated conditions, including lichen planus and lichen planopilaris. TNF-α antagonists have been associated with paradoxical psoriasiform, lichenoid, eczematous, granulomatous, and acneiform eruptions. We detail this case and review the literature of lichenoid reactions secondary to TNF-α inhibitors.

  15. 口腔扁平苔藓患者口腔健康相关生活质量的初步研究%Oral health-related quality of life in patients with oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    左雯鑫; 李晓宇; 陈艳卿; 彭宏

    2012-01-01

    目的 通过口腔健康影响程度量表(OHIP)-14中文版了解口腔扁平苔藓患者口腔健康相关生活质量情况,探讨其应用于口腔扁平苔藓临床诊疗的可靠性和准确性.方法 采用OHIP-14中文版对51例口腔扁平苔藓患者进行问卷调查,同时采用视觉类比标尺(VAS)对疼痛程度进行评分,REU评分系统对病损情况进行评分.通过SPSS 16.0软件对量表的信度和效度进行统计分析.结果 0HIP-14的得分为21.67±9.45,量表的内部一致性Cronbach's α系数为0.901,因子分析提取的5个公因子与量表各领域有密切的逻辑关系,量表得分与REU分值和VAS分值间呈正相关关系(r=-0.608,0.807; P<0.000).结论 OHIP-14中文版评测口腔扁平苔藓患者的口腔健康相关生活质量具有较好的信度和效度,可为病情评估提供参考.%Objective To investigate the oral health-related quality of life in patients with oral lichen planus(OLP) using the Chinese version of the oral health impact profile (OHIP)-14. Methods 51 patients with OLP were included and completed the questionnaire of OHIP-14 subsequently the REU scoring system was utilized to record the local condition and a visual analogue scale (VAS) to rate the pain they experienced. The reliability and validity were analyzed by SPSS 16.0 software. Results The score of OHIP-14 was 21.67±9.45, Cronbach's alpha of the translated scale was 0.901. The items were divided into 5 domains by factor analysis. There was certain logical relation between the items in the same domain. There was highly significant association between the OHIP-14 score and REU score as well as VAS score (r=0.608, 0.807, P<0.000). Conclusion OHIP-14 performs well in patients with OLP, and have good validity and reliability.

  16. Association between interleukin 23R gene polymorphisms and oral lichen planus%IL-23R 基因多态性与口腔扁平苔癣的相关研究

    Institute of Scientific and Technical Information of China (English)

    和慧; 刘长欢; 肖欣; 陈英新

    2015-01-01

    Objective To investigate single nucleotide polymorphisms(SNP)of interleukin 23R gene with oral lichen planus(OLP)in northeast china,and to provide an important genetic basis in exploring the disease susceptibility and di-verse clinical manifestation.Methods 66 patients with OLP (21 erosive OLP patients)and 70 healthy control subjects were recruited.Genomic DNA was extracted and PCR products spanning two SNPs of the IL-23R gene at positions (rs10889677 and rs11465817)were analyzed.The genotype frequencies were calculated and analyzed.Results ①The rs10889677,rs11465817 allele and genotype frequency distribution of the difference in the case group and the control group had no statistical significance (P >0.05).②The rs10889677 genotype frequency distribution in erosive compared with the control group had significant difference (P =0.024),the CC+CA genotype of the individual risk occurrence of erosion type is 3.115 times of the AA genotype (95%CI:1.135~8.548).Conclusion The Northeast OLP population of IL-23R gene rs11465817 locus SNP had no significant correlation existed in OLP disease susceptibility;polymor-phism of rs10889677 point mutation,may be associated with disease susceptibility and severity of OLP.%目的:研究东北地区 IL-23R 基因多态性与口腔扁平苔癣的相关性。方法采用聚合酶链反应—限制性片段长度多态性(PCR-RFLP)检测66例口腔扁平苔癣患者(其中糜烂型21例)和70例健康健康对照者的 IL-23R 的两个 SNP 位点(rs10889677和 rs11465817),分析 IL-23R 基因多态性与口腔扁平苔癣的相关性。结果①rs10889677、rs11465817位点等位基因、基因型分布频率在病例组和对照组间差异无统计学意义(P >0.05);② rs10889677位点基因型分布频率在糜烂型与对照组比较差异有统计学意义(P=0.024),CC+CA 基因型个体发生糜烂型的风险是AA 基因型的3.115倍(95%CI:1.135~8.548

  17. Lichen Sclerosus

    Science.gov (United States)

    ... Health Gynecology Medical Conditions Nutrition & Fitness Emotional Health Lichen Sclerosus Posted under Health Guides . Updated 27 July ... treatments available to help the symptoms. What is lichen sclerosus and what does it look like? Lichen ...

  18. 萎缩糜烂型口腔扁平苔藓患者不同基因型白色念珠菌的药敏研究%Antifungal susceptibility test of genotypes of Candida albicans from patients with atrophic or erosive oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    李景媛; 孙红英; 章强强

    2011-01-01

    PURPOSE: To study the antifungal susceptibility of genotypes of Candida albicans from patients with atrophic or erosive oral lichen planus and provide evidence for the treatment of candidiasis. METHODS: Polymerase chain reaction(PCR) was adopted to analyze 101 Candida albicans which were isolated from atrophic or erosive oral lichen planus.Microdilution broth method was carried out for antifungal susceptibility test. SPSS16.0 software package was used for Chi-square test. RESULTS: A total of 101 strains of Candida albicans were divided into three types,39 were genotype A strains, 17 genotype B stains and 45 genotype C stains.Strains of genotype A were significantly more resistant to 5-fluorocytosine than strains of genotypes B and C (P0.05). CONCLUSIONS: There is a correlation between Candida albicans genotypes and antifungal susceptibility. The use of antifungal agent should be based on the genotypes and antifungal susceptibility test of Candida albicans. For the treatment of candidiasis in patients with atrophic or erosive oral lichen planus, the value of nystatin should be addressed.%目的:对萎缩糜烂型口腔扁平苔藓不同基因型白色念珠菌进行药物敏感性研究,为临床有效治疗萎缩糜烂型口腔扁平苔藓白色念珠菌感染提供依据.方法:采用聚合酶链反应(PCR)对101株萎缩糜烂型口腔扁平苔藓白色念珠菌进行基因分型,然后采用微量稀释法测定白色念珠菌不同基因型对4种临床常用抗真菌药物的敏感性.采用SPSS16.0软件包对数据进行x检验.结果:101株白色念珠菌中,A型39株,B型17株,C型45株.A型对5-氟胞嘧啶耐药率显著高于B、C型(P0.05).结论:萎缩糜烂型口腔扁平苔藓白色念珠菌不同基因型对抗真菌药物的耐药性有差异,治疗时应根据基因分型和药敏试验结果合理选用抗真菌药物.治疗萎缩糜烂型口腔扁平苔藓伴发白色念珠菌感染时,制霉菌素的临床价值应该引起充分重视.

  19. 他克莫司治疗糜烂型OLP的随机对照双盲试验%Effect of Tacrolimus on oral lichen planus: A randomized comparative double-blind study

    Institute of Scientific and Technical Information of China (English)

    罗文平; 曾宪涛

    2013-01-01

    目的:评价0.1%他克莫司治疗糜烂型口腔扁平苔癣(OLP)的疗效和安全性.方法:根据相关标准纳入68例糜烂型OLP患者,随机分成两组,双盲法下分别外用0.1%他克莫司和0.05%丙酸氯倍他索治疗,观察和比较两组的总有效率、不良反应发生率及停药6个月后复发率.结果:他克莫司组和丙酸氯倍他索组总有效率分别为97.1%、93.9%,两组间差异无统计学意义(P>0.05);两组间复发率分别为6.5%、10.3%,差异无统计学意义(P>0.05);两组的局部不良反应发生率均较低且无显著差异(P>0.05).结论:局部外用他克莫司在改善OLP患者体征(病损面积)和症状(疼痛)方面效果显著;他克莫司治疗OLP的总有效率、治疗期间局部不良反应发生率及停药后复发率均与糖皮质激素相当.%Objective: To evaluate the treatment efficacy and safety of tacrolimus in oral clichen planus (OLP) compared with glucocorticoid. Method: 68 consecutive patients with oral lesions consistent clinically and histologically with OLP were recruited.The patients were divided into 2 groups to receive clobetasol 0.05 % or tacrolimus 0.1 % ointment and were treated for 4 weeks. Result: The Total effective rate, side-effect incidence and recurrence rates did not differ between the tacrolimus and clobetasol treatment groups (P >0.05) . separately. Conclusion: Tacrolimus could effectively both alleviate pain and reduce lesion area of patient with OPL. Total effective rate or side—effect incidence during treatment or OPL recurrence rate after stopping treatment of tacrolimus is the same with that of glucocorticoid. Further high—quality, multi—center RCTs with standard clinical evaluation are required to provide more reliable evidence.

  20. Determination of human papillomavirus in oral leukoplakia,oral lichen planus and oral squamous cell carcinoma%白斑、扁平苔藓及口腔癌中人类乳头瘤病毒的检测

    Institute of Scientific and Technical Information of China (English)

    曹婕; 金建秋; 邓大君; 刘宏伟

    2016-01-01

    45%(2/58),通过卡方检验差异无统计学意义,P=0.249。结论:没有足够证据证明HPV感染或检测阳性可作为预测OLK癌变的信号;患OLP的患者处于癌前状态,OLP中HPV检出率高于OLK及OSCC,提示OLP患者由于某种原因对HPV易感,可考虑为OLP 患者常规做HPV检测,推荐使用HC-Ⅱ法,同时应对HPV阳性的OLP患者加强随访。%Objective:To investigate the possibility for human papillomavirus (HPV)infection to be a predictable signal for the carcinogenesis of oral mucosa by comparing the prevalences of HPV in each stage of oral mucosal carcinogenesis and to compare the sensitivity differences of the two methods in de-tecting HPV infection in oral cavity.Methods:The hybrid capture (HC-Ⅱ)was used to detect infection of HPV in 255 samples taken from 1 2 cases of healthy oral mucosa,21 1 cases of patients with pathologi-cal diagnosis and 32 cases of patients with clinical diagnosis.The diagnosed cases included 8 cases of be-nign lesions of the oral mucosa,precancerous lesions [74 cases of oral leukoplakia (OLK)with hyper-plasia and 42 cases of OLK with oral epithelial dysplasia (OED)],91 cases of precancerous condition [oral lichen planus (OLP)]and 28 cases of oral squamous cell carcinoma (OSCC).And in situ hybri-dization (ISH)was used to detect infection of HPV in 33 cases of OSCC and 76 cases of OLK,including 30 cases of hyperplasia,1 5 cases of mild OED,1 5 cases of moderate OED and 1 6 cases of severe OED. Results:The prevalence of HPV in OLP samples was higher (1 2.1 2%,8/66 )than that of OLK (2.59%,3/1 1 6)(χ2 =4.666,P=0.031 )and OSCC(7.1 4%,2/28,χ2 =0.51 3,P=0.474).The prevalence of HPV in OSCC (7.1 4%,2/28)was higher than that of OLK (2.59%,3/1 1 6),and no significant difference was found.There was only one case of smoke spot and statistical analysis was not carried out.ISH was used to detect type 1 6/1 8 and type 31 /33 HPV DNA in 1 09 cases of oral mucosal lesions in paraffin

  1. Lichen Sclerosus

    Directory of Open Access Journals (Sweden)

    Şeniz Ergin

    2012-06-01

    Full Text Available Lichen sclerosus is a progressive, inflammatory dermatosis characterized with porcelain white sclerotic plaques most commonly in the anogenital area of postmenopausal women. Children and men can also be affected. Extragenital involvement may occur. Even though the etiology is unknown; autoimmune, genetic, hormonal and infectious factors are suggested. Lichen sclerosus is associated with autoimmune diseases such as thyroid disease, alopecia areata, vitiligo, diabetes and pernicious anemia. An increased incidence of autoantibodies to the extracellular matrix protein 1 is shown in sera of patients with lichen sclerosus. Familial occurence and an association with HLA DQ7 supports the presence of genetic factors in its etiology. However, the role of estrogen and androgens could not be demonstrated as etiologic factors. Clinical similarity with acrodermatitis chronica atrophicans led researches to be held for the detection of Borrelia burgdorferi antibodies ended with conflicting results. Disease may be triggered with trauma in the presence of genetic predisposition. Pruritus is the main symptom. Pain, burning and dysesthesia may occur. Lichen sclerosus may be confused with sexual abuse in girls. Furthermore, it is more severe in the presence of sexual abuse. If not treated it leads to permanent anatomical disorders in the anogenital region. It is one of the most common cause of acquired phimosis in boys. Meatal stenosis and urinary obstruction may develop. Erectile dysfunction and dyspareunia due to introital stenosis may cause psychosexual problems in men and women. Perianal involvement causes constipation in women and girls. Long-standing anogenital lesions have the risk of developing squamous cell carcinoma. Verrucous carcinoma rarely occurs. Extragenital symptoms do not have similar risks. Ultra-potent topical corticosteroids are used as the first line therapy. In the case of unresponsiveness to corticosteroids the alternative approaches are

  2. Lichen Sclerosus

    Directory of Open Access Journals (Sweden)

    Şeniz Ergin

    2012-06-01

    Full Text Available Lichen sclerosus is a progressive, inflammatory dermatosis characterized with porcelain white sclerotic plaques most commonly in the anogenital area of postmenopausal women. Children and men can also be affected. Extragenital involvement may occur. Even though the etiology is unknown; autoimmune, genetic, hormonal and infectious factors are suggested. Lichen sclerosus is associated with autoimmune diseases such as thyroid disease, alopecia areata, vitiligo, diabetes and pernicious anemia. An increased incidence of autoantibodies to the extracellular matrix protein 1 is shown in sera of patients with lichen sclerosus. Familial occurence and an association with HLA DQ7 supports the presence of genetic factors in its etiology. However, the role of estrogen and androgens could not be demonstrated as etiologic factors. Clinical similarity with acrodermatitis chronica atrophicans led researches to be held for the detection of Borrelia burgdorferi antibodies ended with conflicting results. Disease may be triggered with trauma in the presence of genetic predisposition. Pruritus is the main symptom. Pain, burning and dysesthesia may occur. Lichen sclerosus may be confused with sexual abuse in girls. Furthermore, it is more severe in the presence of sexual abuse. If not treated it leads to permanent anatomical disorders in the anogenital region. It is one of the most common cause of acquired phimosis in boys. Meatal stenosis and urinary obstruction may develop. Erectile dysfunction and dyspareunia due to introital stenosis may cause psychosexual problems in men and women. Perianal involvement causes constipation in women and girls. Long-standing anogenital lesions have the risk of developing squamous cell carcinoma. Verrucous carcinoma rarely occurs. Extragenital symptoms do not have similar risks. Ultra-potent topical corticosteroids are used as the first line therapy. In the case of unresponsiveness to corticosteroids the alternative approaches are

  3. 局部注射曲安奈德和卡介菌多糖核酸治疗口腔扁平苔藓的临床研究%Local Injection of Triamcinolone Acetonide Injection and Bcg Polysaccharide and Nucleic Acid for Oral Lichen Planus:A Report Of 134 Cases

    Institute of Scientific and Technical Information of China (English)

    刘立访; 邓雪莲; 于春梅

    2015-01-01

    [Objective]To explore the therapeutic efficacy of local injection of triamcinolone acetonide injection ,BCG polysaccharideand nucleic acid injection for oral lichen planus .[Methods]A total of 268 patients with oral lichen planus confirmedby pathological examination were randomly divided into observation ( n = 134) and control ( n = 134) groups by number randommethod .Observation group were divided into subgroup A (erosion type ,n = 66) and subgroup B (non‐erosion type ,n =68) according to the results of pathological examination .And control group were also divided into subgroups C (erosion type , n = 65) and D (non‐erosion type ,n = 69) according to the results of pathological examination .The control group received 40mg triamcinolone acetonide and 2 mL 2% lidocaine injection in lesion base .On the basis of control group ,observation grouphad 1 mL BCG polysaccharide and nucleic acid injection in lesion base .The efficacies ,serum levels of inflammatory factors ,recurrenceand occurrence of adverse reactions of two groups were statistically analyzed .[Results]The rates of efficacy and totalefficacy were 58 .21% and 58 .21% in observation group versus 40 .30% and 84 .33% in control group ( P 0 .05) .The serum levels of interleukin‐6 (IL‐6) ,tumor necrosis factor‐alpha (TNF‐α) and other inflammatory factor levels before andafter treatment of group A and group B and serum IL‐6 and TNF‐α and other inflammatory factor levels before and after treatmentof group C and group D had no statistical significant difference ( P > 0 .05) .Compared with group A and group B ,serumlevels of group C were higher after treatment with 1 week ,3 weeks and 6 weeks .And the serum level of group D were alsohigher during the same period ( P < 0 .05) .Recurrence rates 1 month ,3 months ,6 months after treatment of group A werelower than those .And recurrence rates 1 month ,3 months ,6 months after treatment in group B were also lower than those ingroup D ( P < 0 .05

  4. Short-term efficacy of Xipayi mouth rinse and sodium bicarbonate in patients with oral lichen planus%西帕依固龈液与碳酸氢钠溶液联合治疗口腔扁平苔藓疗效观察

    Institute of Scientific and Technical Information of China (English)

    李向利; 钟焱; 王素云

    2010-01-01

    目的 观察西帕依固龈液与碳酸氢钠溶液联合应用治疗口腔扁平苔藓(oral lichen planus, OLP)的短期疗效.方法 97例OLP患者随机分为A组47例和B组50例, A组采用西帕依固龈液与4%碳酸氢钠溶液交替含漱,B组采用凉开水与4%碳酸氢钠溶液交替含漱,采取双盲原则进行局部用药.治疗6周后对两组充血程度、病变大小、疼痛程度等临床指标进行观察.结果 A组同B组相比,充血程度、病变大小、疼痛程度等指标明显降低,差异有统计学意义(P<0.05).结论 西帕依固龈液与碳酸氢钠溶液联合应用治疗口腔扁平苔藓具有较好的短期临床疗效.

  5. Lichen Nitidus

    Science.gov (United States)

    Diseases and Conditions Lichen nitidus By Mayo Clinic Staff Lichen nitidus (LIE-kun ni-TIE-dus) is a rare skin condition that usually ... glistening bumps on the surface of your skin. Lichen nitidus results from abnormal inflammatory activity in skin ...

  6. A Case of Familial Lichen Amyloidosis

    Directory of Open Access Journals (Sweden)

    Şeniz Ergin

    2008-12-01

    Full Text Available Familial lichen amyloidosis which is also referred to familial primary cutaneous amyloidosis is a rare clinical variant of cutaneous amyloidosis. Lichen amyloidosis is characterized by persistent, pruritic, small brown papules often located on anterior surfaces of legs which show tendency to form plaques. Amyloid deposits would be identified in papillary dermis in histopathological examination. In our clinic, a 42 year old woman with a widespread involvement describing that similar skin findings were present in her both daughters, elder brother and her nephew was evaluated with suspicion of lichen amyloidosis. In histopathological examination of the involved skin, because of determining amyloid deposits in papillary dermis the case was cited as lichen amyloidosis. Our case was searched for the accompanying diseases such as atopic dermatitis, chronic urticaria, lichen planus, multiple endocrine neoplasia and Kimura disease. The family history of our patient was consistent with autosomal dominant inheritance. Familial lichen amyloidosis has been reported as cases with autosomal dominant inheritance from Russia, Germany, United Kingdom and South America. The genetic researches over familial lichen amylodiosis are limited to the cases with multiple endocrine neoplasia. In this rarely reported cases, further genetical researches are necessary in order to determine the responsible gen locus. (Turkderm 2008; 42: 137-9

  7. Antigen mimicry followed by epitope spreading: a pathogenetic trigger for the clinical morphology of lichen planus and its transition to Graham Lassueur Piccardi Little Syndrome and keratosis lichenoides chronica - Medical hypotheses or reality? Mimetismo antigênico seguido de espalhamento de epítopos: agente desencadeador patogênico da morfologia clínica do líquen plano e de sua transição para a Síndrome de Graham-Little-Piccardi-Lassueur e para a ceratose líquenóide crônica - Hipótese médica ou realidade?

    Directory of Open Access Journals (Sweden)

    Georgi Tchernev

    2009-12-01

    Full Text Available Literature data analysis, providing an exact explanation of the lichen planus pathogenesis, as well as its transition into other rare forms such as Keratosis lichenoides chronica or Graham Lassueur Piccardi Little Syndrome are scant, or totally missing. The chronological course of the disease, known in the literature as lichen planus, varies. Some patients develop Lichen planus or lichen nitidus and there is no logical explanation why. It is also not clear why single patients initially develop ulcerative lesions in the area of the mucosa and only in a few of them these lesions affect the skin. Antigen Mimicry and Epitope Spreading could be the possible pathogenic inductor in cases of lichenoid dermatoses, as well as the cause for their transition into ulcerative, exanthematous or other rare forms. The Epitope Spreading is probably not the leading pathogenetic factor in lichen planus but a phenomenon which occurs later. This manuscript analyzes some basic pathogenic aspects and presents some possible medical hypotheses regarding the heterogenic clinical picture and pathogenesis of lichen planus and lichenoid like pathologies of the skin which, in the near future should be analyzed in details in order to clarify several dilemmas the clinical dermatologist has to face.Análises das informações disponíveis na literatura que forneçam uma explicação precisa sobre a patogênese do Líquen Plano, assim como sobre sua transição para outras formas raras da doença, como Ceratose Liquenóide Crônica ou Síndrome de Graham-Little-Piccardi- Lassueur , são raras ou inexistentes. O curso cronológico da doença, conhecida na literatura como Líquen Plano, varia. Alguns pacientes desenvolvem Líquen Plano ou Líquen Nítido e não ha uma explicação lógica do por quê. Também não está claro por que alguns pacientes inicialmente desenvolvem lesões ulcerativas na área da mucosa e em apenas alguns deles essas lesões afetam a pele. Mimetismo Antig

  8. CD45RA、CD45RO及胞间黏附分子1在扁平苔藓皮损中的表达%Expression of CD45RA, CD45RO and ICAM-1 in the lesions of patients with lichen planus

    Institute of Scientific and Technical Information of China (English)

    刘丽娟; 张国强; 贾金海; 李鑫; 丁政云

    2014-01-01

    目的:探讨扁平苔藓(LP)皮损CD45RA、CD45RO及胞间黏附分子1(ICAM-1)的表达及意义。方法应用免疫组化方法检测35例 LP 皮损和20例正常皮肤组织中 CD45RA、CD45RO及ICAM-1的表达水平。结果 LP皮损真皮内可见到CD45RO阳性表达,与正常对照组有统计学差异(P<0.05);LP皮损表皮、真皮及真皮内小血管壁内皮细胞内均可见ICAM-1阳性表达,与正常对照组有统计学差异(均P<0.05);两组均未见CD45RA阳性细胞表达。结论 LP皮损真皮内浸润细胞以记忆T细胞亚群为主,LP皮损角质形成细胞异常表达ICAM-1,推测ICAM-1参与了皮损角质形成细胞抗原呈递过程,从而促进记忆T细胞离开血管,向真皮及表皮浸润。%ObjectiveTo investigate the expression of CD45RA, CD45RO and ICAM-1 in the lesions of patients with lichen planus.Methods The expression levels of CD45RA and CD45RO and ICAM-1 were detected in 35 cases of LP lesion tissue and 20 cases of normal skin tissue by using immunohistochemical methods.Results CD45RO positive expression can be seen in the dermis of LP lesions, and had statistical difference compared with normal control group (P<0.05); the positive expression of ICAM-1 were visible within LP skin epidermis, dermis and small blood vessels endothelial cells in the dermis, and had statistical difference compared with the normal control group (allP<0.05); CD45RA positive cells expression were not found in both groups.Conclusion The dermal infiltrating cells are mainly memory T cells subset in the lesions of lichen planus, the significant expression of ICAM-1 in keratinocytes of LP patients suggest that ICAM-1 take part in the progress of the antigen-submit of keratinocytes, and promote the inflammatory cells infiltrating to epidermis.

  9. Expression of Candida albicans Secretory Aspartyl Proteinases in the Saliva of Oral Lichen Planus Patients%白色念珠菌分泌型天冬氨酸蛋白酶在口腔扁平苔藓患者唾液中的表达

    Institute of Scientific and Technical Information of China (English)

    张英; 闻妍; 康媛媛; 钟鸣

    2012-01-01

    研究白色念珠菌分泌型天冬氨酸蛋白酶(SAP)家族在扁平苔藓患者唾液中的表达,进而探讨白色念珠菌病与扁平苔藓的关系.选取白色念珠菌携带者、白色念珠菌病患者、携带白色念珠菌的扁平苔藓患者、伴有白色念珠菌病的扁平苔藓患者各20例,念珠菌培养阴性的扁平苔藓患者10例.从唾液标本中直接提取RNA,进行RT-PCR.白色念珠菌携带者唾液中有SAP2、SAP4-6、SAP7的不同表达,携带白色念珠菌的口腔扁平苔藓患者唾液中有SAP2、SAP4-6、SAP7、SAP8、SAP9的不同表达,所有携带者中均未表现SAP1、SAP3和SAP10的阳性扩增.白色念珠菌患病者及伴有白色念珠菌病的口腔扁平苔藓患者唾液中有SAP1-10的不同表达.念珠菌培养阴性的扁平苔藓患者均无SAP1-10的阳性扩增.SAP9与扁平苔藓密切相关.%Expressions of secretory aspartyl proteinase ( SAP) family of Candida albicans in oral lichen planus ( OLP) patients was studied to reveal the relation between OLP and C. Albicans infections. The carriers of C. Albicans and candidiasis patients, OLP patient with C. Albicans carriers, and OLP patients accompanied with candidiasis 20 cases each, and 10 cases of OLP patients with C. Albicans culture negative were selected. The RNA directly extracted from saliva was carried out RT-PCR. There were different expressions of SAP2, SAP4-6, and SAP7 in saliva of C. Albicans carriers, and there were different expressions of SAP2, SAP4-6, SAP7, SAP8, and SAP9 in saliva of OLP patient with C. Albicans carriers, positive amplification of SAP1, SAP3, and SAP 10 were not found in all carriers. There were different expressions of SAP1-10 in saliva of candidiasis patients and OLP patients accompanied with candidiasis. OLP patient with C. Albicans culture negative had no SAP1-10 positive amplification. SAP9 had close correlation to oral lichen planus.

  10. Lichen nitidus presenting with nail changes--case report and review of the literature.

    Science.gov (United States)

    Tay, Evelyn Yuxin; Ho, Madeline Sheun Ling; Chandran, Nisha Suyien; Lee, Joyce Siong-See; Heng, Yee Kiat

    2015-01-01

    Lichen nitidus of the nail is rare and can precede the onset of skin lesions. Delayed diagnosis is common. We present an unusual case of lichen nitidus-associated nail changes that preceded the onset of skin lesions in a 4-year-old Indian girl. We also conduct a review of six other cases of lichen nitidus with nail involvement from the English-language literature. Clues to the diagnosis of lichen nitidus include violaceous or pigmentary changes of the nail fold and subtle lichenoid papules on the affected digits. Lichen nitidus of the nails appears to be less severe than nail changes of lichen planus and is generally self-limiting. Understanding the natural history of lichen nitidus of the nails will help physicians better counsel patients and their families.

  11. The research development of oral lichen planus and hepatitis C virus%口腔扁平苔藓与丙型肝炎病毒的研究进展

    Institute of Scientific and Technical Information of China (English)

    石晶; 曾昕; 陈谦明

    2006-01-01

    口腔扁平苔藓(oral lichen planus,OLP)是目前口腔黏膜疾病中除复发性口腔溃疡之外的多见病,其病因未明,治疗过程中病情常反复发作或迁延不愈,给患者造成较大的生理和精神痛苦。目前研究发现丙型肝炎病毒(hepatitis Cvirus,HCV)感染与OLP的发生、发展具有相关性,这一发现可能为OLP的病因研究及临床治疗都带来新思路和新策略。我们就OLP与HCV感染关系综述如下。

  12. The relevance of oral leukoplakia and oral lichen planus to gene single uncleotide polymorphism%口腔白斑与扁平苔藓单核苷酸基因多态性研究进展

    Institute of Scientific and Technical Information of China (English)

    魏本娟; 周曾同

    2006-01-01

    单核苷酸多态性(single nucleotide polymorphism,SNP)是人类基因组中最丰富的一种DNA序列变化,发生在基因内或其邻近序列的SNP控制个体之间表型的差异,包括疾病的易感性和对药物的反应等。口腔白斑(oral leukoplakia,OLK)和口腔扁平苔藓(oral lichen planus,OLP)是一组常见的口腔黏膜病,关于这两种疾病的多态性研究近年来正悄然兴起,现简要综述这两种疾病的SNP研究进展。

  13. Progress in Immunopathogenesis Research on Pathological Changes of Oral Lichen Planus%口腔扁平苔藓病理改变的免疫发病机制研究进展

    Institute of Scientific and Technical Information of China (English)

    孙红英; 胡宝洋; 周国民; 俞立英

    2005-01-01

    口腔扁平苔藓(oral lichen planus,OLP)是最常见的非感染性口腔黏膜疾病,主要累及颊部、舌及牙龈等部位,有时可合并皮肤病变。病变可呈条纹状、斑块状白色损害、黏膜糜烂、萎缩等多种表现。该病在成人中发病率为1%~4%,易发于40岁以上的成人,女性多见。一般认为,本病与自身免疫、神经精神、全身疾病等因素有关,但确切机制不详。近年来OLP在组织病理学损伤机制方而取得了一定进展,如细胞黏附分子的改变可影响淋巴细胞迁移入上皮组织;

  14. Lichen sclerosus.

    OpenAIRE

    Şeniz Ergin

    1990-01-01

    Lichen sclerosus is a progressive, inflammatory dermatosis characterized with porcelain white sclerotic plaques most commonly in the anogenital area of postmenopausal women. Children and men can also be affected. Extragenital involvement may occur. Even though the etiology is unknown; autoimmune, genetic, hormonal and infectious factors are suggested. Lichen sclerosus is associated with autoimmune diseases such as thyroid disease, alopecia areata, vitiligo, diabetes and pernicious anemia. An ...

  15. Correlation between expression of granzyme B and perforin and apoptosis in epithelial cells in oral lichen planus with local lymphocyte infiltration%口腔扁平苔藓局部浸润淋巴细胞颗粒酶B和穿孔素蛋白表达与上皮细胞凋亡的关系

    Institute of Scientific and Technical Information of China (English)

    雷蕾; 詹丽华; 谭为霞; 周序珑

    2011-01-01

    目的 检测口腔扁平苔藓(oral lichen planus,OLP)上皮细胞凋亡状况,观察颗粒酶B、穿孔素在OLP固有层浸润淋巴细胞中的蛋白表达,探讨细胞毒作用对OLP上皮细胞凋亡的影响。方法采用原位缺口末端DNA标记技术,定位检测OLP上皮细胞凋亡情况;分别使用免疫组化法检测颗粒酶B和穿孔素在组织总淋巴细胞以及CD8+细胞中的表达,以健康口腔黏膜组织(NOM)作对照。结果与NOM相比,OLP上皮细胞凋亡显著增加(P=0.037);OLP淋巴细胞中颗粒酶B、穿孔素表达明显增强(P值分别为0. 016和0.012),其部分阳性细胞接近上皮基底层。OLP中CD8+/颗粒酶B+细胞双阳性表达和CD8+/穿孔素+细胞双阳性表达较NOM明显升高(P值分别为0.043和0.032)。OLP上皮细胞凋亡与淋巴细胞颗粒酶B和穿孔素表达成正相关(r=0.56,P=0. 038;r =0.42,P=0.041)。结论OLP浸润淋巴细胞包括CD8+T细胞中颗粒酶B、穿孔素表达增强,提示OLP淋巴细胞可能以颗粒酶B、穿孔素作为细胞毒介质攻击口腔上皮细胞引起其凋亡。%Objective To study the expression of granzyme B and perform and the effect of cytotoxin on apoptosis of epithelial cells in oral lichen planus( OLP) with lymphocyte infiltration by detecting the apoptosis of epithelial cells. Methods Apoptosis of epithelial cells in OLP with lymphocyte infiltration was detected with the terminal deoxymuleotigyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) technique. Expression of granzyme B and perfoin in lymphocytes and CD8+ cells was detected with the immunohistochemcial method. Normal oral mucosa( NOM) was used as a control. Results The apoptosis level of epithelial cells and the expression level of granzyme B and perforin were significantly higher in epithelium of OLP than in control (P <0. 05). Some positive cells were observed in the basal lamina of epithelium. The double positive expression levels of CD8

  16. 口腔扁平苔藓患者情绪障碍与唾液皮质醇和脱氢表雄酮水平的相关性%Association between the mood obstacle and salivary cortisol, DHEA lev-els in patients with oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    莫珩; 高承志; 王少杰; 曲姗

    2015-01-01

    Aim:To explore the relationship between scores of anxiety , depression and the salivary levels of cortisol , DHEA in patients with oral lichen planus ( OLP) .Methods:Thirty-one patients with erosive oral lichen planus ( EOLP) ,40 patients with non-EOLP and 31 control patients were investigated by the instruments Hamilton Anxiety Scale and Hamilton Depression Scale , respectively .Saliva was collected in the morning for the determination of cortisol , DHEA levels by radio-immunoassay to explore the relationship between scores of anxiety , depression and the salivary levels of cortisol , DHEA in the three groups .Results:There were significant differences in the scores of HAMA , HAMD and the concentration of sali-vary cortisol of objects in three groups (F=15.892,4.876 and 14.375,P<0.05).Compared with controls and patients with non-EOLP, the scores of HAMA , HAMD and the concentration of salivary cortisol in patients with EOLP were signifi-cantly higher(P<0.05).In addition, the concentration of salivary cortisol in patients with EOLP was positively correlated with their scores of HAMA(r =0.965,P<0.001) and HAMD (r =0.923,P<0.001).The concentration of salivary DHEA in patients with EOLP was negatively correlated with their scores of HAMA ( r=-0.948,P<0.001) and HAMD (r=-0.966,P<0.001).The concentration of salivary cortisol in patients with non-EOLP was positively correlated with their cores of HAMA (r=0.963,P<0.001) and HAMD (r=0.957,P<0.001).The concentration of salivary DHEA in patients with non-EOLP was negatively correlated with their scores of HAMA ( r =-0.962, P <0.001 ) and HAMD (r=-0.971,P<0.001).Conclusion:The pathogenesis and exacerbation of EOLP could be inferred by the mood obsta-cle.Anxiety and depression may result in higher concentration of salivary cortisol in patients with EOLP by means of psy -chosomatic response to stress .While the relation between anxiety , depression and lower salivary DHEA levels in patients with EOLP remains unclear and more

  17. Expression of miRNA-155 and miRNA-146a in peripheral blood mononuclear cells and plasma of oral lichen planus patients%口腔扁平苔藓患者外周血微小RNA-155和146a的表达

    Institute of Scientific and Technical Information of China (English)

    刘汾; 吴建勇; 叶芳

    2015-01-01

    Objective To investigate the expression and clinical significance of miRNA-155 and miRNA-146a in peripheral blood mononuclear cells(PBMC) and plasma of oral lichen planus(OLP) patients.Methods Twenty-five female and seven male OLP patients(OLP group) aged 25 to 54 years were selected from January 2012 to May 2013.The diagnosis was confirmed by pathology and the lesions were divided into two non-erosive OLP group(18 cases) and erosive OLP group(14 cases).Twenty healthy sex and age matched volunteers served as control,miRNA-155 and miRNA-146a expressions in PBMC and plasma were examined by real-time PCR.The difference between OLP group and control group was statistically analyzed.Results The expressions of PBMC and plasma miRNA-155 were higher in OLP patients than those in the healthy control (median,0.07 vs 0.03,P<0.05; 5.84 vs 1.32,P<0.01).The median expression level of miRNA-146a in PBMC and plasma of OLP patients and healthy controls were (1.26 vs 0.58,P<0.05) and (412.60 vs 238.42,P<0.01).The plasma miRNA-155 and miRNA-146a expressions were significantly higher in erosive OLP group than those in non-erosive OLP group.There were no significant differences in the expression of PBMC miRNA-155 and miRNA-146a between the two groups.Conclusions The expressions of PBMC and plasma miRNA-155 and miRNA-146a are higher in OLP patients.The expressions of plasma miRNA-155 and miRNA-146a are associated with OLP severity.The over expression of miRNA-155 and miRNA-146a in OLP may play a role in the pathogenesis of OLP.%目的 探讨口腔扁平苔藓(oral lichen planus,OLP)患者外周血单个核细胞(peripheralbloodmononuclearcell,PBMC)和血浆中微小RNA (micro RNA,miRNA) 155 (miRNA-155)及miRNA-146a的表达,阐明其在OLP发病中的作用及意义.方法 收集2012年1月至2013年5月南昌大学附属口腔医院口腔内科收治的OLP患者32例(OLP组),其中女性25例,男性7例,年龄25~54岁.所有OLP患者均为初诊且经病理学确诊,按照

  18. [Multiple extrahepatic manifestations in a patient with chronic hepatitis C treated with interferon-alfa].

    Science.gov (United States)

    Napoli, Nicola; Tortorella, Cosimo; Deramo, Maria Teresa; Antonaci, Alessandra; Parisi, Carmen Vita; Antonaci, Salvatore

    2004-11-01

    The case of a 61-years-old female patient with chronic hepatitis C who developed multiple consecutive extrahepatic manifestations is reported. One of these manifestations (lichen planus) appeared before HCV-related chronic hepatitis was diagnosed and treated with interferon-alpha, suggesting that it was likely associated with HCV itself. Other manifestations appeared during IFN-alpha treatment (polyarthritis) or after the end of treatment (ulcerative cholitis, sarcoidosis) implying a role for either HCV or IFN-alpha treatment in the pathogenesis of extrahepatic manifestations.

  19. Associação entre líquen plano e infecção pelo vírus da hepatite C: um estudo prospectivo envolvendo 66 pacientes da clínica de dermatologia da Santa Casa de Misericórdia de São Paulo Association between lichen planus and hepatitis C virus infection: a prospective study with 66 patients of the dermatology department of the hospital Santa Casa de Misericórdia de São Paulo

    Directory of Open Access Journals (Sweden)

    Thais Dias Tavares Guerreiro

    2005-10-01

    Full Text Available FUNDAMENTOS: O líquen plano é dermatose inflamatória crônica de etiologia desconhecida. Sua associação com doença hepática, particularmente a hepatite C, é tema de diversos trabalhos em todo o mundo, desde 1990, quando a sorologia para detecção do vírus da hepatite C (VHC se tornou disponível. OBJETIVOS: Este estudo visa avaliar uma possível relação causal entre a infecção pelo vírus C e o líquen plano. MÉTODOS: Tomaram-se por grupo de estudo 66 pacientes com líquen plano matriculados na Clínica de Dermatologia da Santa Casa de Misericórdia de São Paulo, no período de 2000 a 2003. O grupo comparativo foi constituído pelos doadores de sangue voluntários do Banco de Sangue da Santa Casa de Misericórdia de São Paulo, durante o período de outubro de 2001 a outubro de 2002. RESULTADOS: Dos 66 pacientes com líquen plano, cinco apresentaram sorologia positiva para VHC, representando 7,5% em comparação com 0,69% dos doadores de sangue. CONCLUSÕES: Esse resultado é compatível com muitos dados contidos na literatura médica mundial. Entretanto, são necessários novos estudos para o melhor conhecimento dessa controversa relação.BACKGROUND: Lichen planus is a chronic inflammatory dermatosis of unknown etiology. Its association with liver diseases, particularly hepatitis C, has been widely approached since 1990, when serology for the detection of hepatitis C virus became available. OBJECTIVES: The objective of this study was to evaluate a possible causal relation between virus C infection and lichen planus. METHODS: Sixty-six patients with lichen planus seen at the Dermatology Department of Santa Casa de Misericórida de Sao Paulo from 2000 to 2003 were included in the study group. The control group comprised volunteer blood donors of the Blood Bank of Santa Casa de Misericórida de Sao Paulo, from October 2001 to October 2002. RESULTS: Five out of the 66 patients with lichen planus had a positive serology for HCV

  20. [Lichen sclerosus

    NARCIS (Netherlands)

    Rossum, M.M. van; Avoort, I.A.M. van der; Hoop, D. de; Dukel, L.; Vleuten, C.J.M. van der; Hullu, J.A. de

    2007-01-01

    Lichen sclerosus is a chronic disorder of skin and mucosa which affects patients of all age groups, particularly women, but also men. It is most commonly seen on the female genital skin, but it also occurs on extragenital areas. Most patients complain of itching and, less frequently, a burning

  1. What Is Lichen Sclerosus?

    Science.gov (United States)

    ... Lichen Sclerosus Find a Clinical Trial Journal Articles Lichen Sclerosus PDF Version Size: 57 KB Audio Version ... Size: 8.6 MB November 2014 What Is Lichen Sclerosus? Fast Facts: An Easy-to-Read Series ...

  2. Levels of interlukin-6 and tumor necrosis factor-α in saliva of patients with type 2 diabetes mellitus and oral lichen planus%2型糖尿病伴口腔扁平苔藓患者唾液白细胞介素-6和肿瘤坏死因子-α水平

    Institute of Scientific and Technical Information of China (English)

    刘洋; 金建秋; 袁振芳; 刘晓松; 曹婕; 郭晓蕙; 刘宏伟

    2011-01-01

    目的:探讨2型糖尿病( type 2 diabetes mellitus,T2DM)和口腔扁平苔藓(oral lichen planus,OLP)患者的唾液白细胞介素-6(interleukin-6,IL-6)和肿瘤坏死因子-α(tumor necrosis factor,TNF-α)水平以及相关影响因素.方法:受试者分为4组:T2DM/OLP组29例,T2DM组39例,OLP组21例,健康对照组43例.用酶联免疫吸附测定(enzyme-linked immuno sorbent assay,ELISA)的方法检测4组受试者唾液中IL-6和TNF-α的水平.结果:(1)T2DM/OLP组的唾液IL-6水平[(12.30±16.03) g/L]显著高于T2DM组[(6.29±5.91) ng/L]和OLP组[(3.64±4.47) ng/L],P<0.05;OLP组的唾液IL-6水平(3.64±4.47ng/L)显著低于健康对照组(7.91±4.05ng/L),P<0.001;T2DM组的唾液TNF-α水平(8.80±8.41 ng/L)显著低于OLP组(14.02±9.65 ng/L)和健康对照组(15.02±6.13 ng/L),P<0.05.(2) T2DM/OLP组唾液TNF-α水平与唾液pH值呈显著性负相关,r=-0.593,P<0.01;在健康对照组,受试者的腰围与唾液IL-6水平(r=0.318,P<0.05)和TNF-α水平(r=0.312,P=0.05)分别呈显著性正相关.(3) OLP患者唾液IL-6、TNF-α水平与OLP临床分型亦显著正相关,P<0.05.(4)当T2DM和OLP协同作用时,减弱了T2DM对唾液TNF-α水平的影响,而增强了T2DM对唾液IL-6水平的影响(P<0.05).结论:当T2DM并发OLP时,两者的协同作用可能使唾液IL-6水平显著升高;唾液TNF-α水平和口腔局部酸碱度有关.

  3. Expressions of Bcl-2 and Bax in Oral Leukoplakia and Oral Lichen Planus and Their Significance%Bcl-2与Bax蛋白在口腔黏膜白斑和扁平苔藓组织中表达及意义

    Institute of Scientific and Technical Information of China (English)

    满一; 钟良军; 王国锋

    2012-01-01

    [目的]探讨扁平苔藓、口腔白斑病变发展过程中细胞凋亡相关蛋白Bcl-2和Bax表达,分析其意义.[方法]选择正常口腔黏膜上皮25例(A组),口腔黏膜白斑29例(B组),扁平苔藓25例(C组),比较三组细胞凋亡指数(AI)、Bcl-2与Bax蛋白表达水平.[结果]A组AI 14.41±0.01显著低于B组、C组的47.16±0.05、39.42±0.14,其差异有统计学意义(p<0.05);与A组相比,B组和C组的Bcl-2,Bax阳性表达率明显提高(P<0.01),染色强度随增生程度而增加,Bax表达随组织学分级而增强.[结论]在白斑的病变发展与恶转过程中,口腔黏膜上皮细胞的凋亡状况发生质与量的变化,Bcl-2、Bax可能参与了白斑癌变的转化过程,但二者的作用相互对抗.扁平苔藓的发病机制可能与Bcl-2在特定部位的表达有关.%[Objective]To explore the expressions of apoptosis-related protein Bcl-2 and Bax in the development of oral leukoplakia(OLK) and oral lichen planus(OLP) , and to analyze their significance. [Methods] Totally 25 cases of normal oral mucosa epithelium(group A) , 29 cases of OLK(group B) and 25 cases of OLP(group C) were chosen. Apoptosis index(AI) and the expressions of Bcl-2 and Bax were compared among 3 groups. [Re-sults] AI in group A was 14. 41 + 0. 01, which was obviously lower than that in group B and C(47. 16 + 0. 05 and 39.42 + 0. 14), and there were significant differences( P

  4. 口腔扁平苔藓病损区白细胞介素12p40和干扰素-γ的表达及意义%Expression of interleukin-12p40 and interferon-γ in local lesions of human oral lichen planus

    Institute of Scientific and Technical Information of China (English)

    潘玉霞; 蔡扬; 余红兵

    2011-01-01

    目的 探讨白细胞介素12p40(IL-12p40)及干扰素-γ(IFN-γ)在口腔扁平苔藓(OLP)病损形成及发展中的意义.方法 正常口腔黏膜组织11例,OLP组织43例,采用免疫组织化学Envision二步法检测IL-12p40和IFN-γ的表达情况,分析其与OLP患者临床病理特征的关系.结果 1)OLP组IL-12p40与IFN-γ的阳性表达率均高于正常对照组,差异有统计学意义(P<0.05).2)在OLP组中,IL-12p40阳性表达率在IFN-γ阳性组高于IFN-γ阴性组,差异有统计学意义(X2=5.828,P=0.016),IFN-γ和IL-12p40表达之间存在正相关关系(r=0.357,P=0.019).3)IL-12p40的阳性表达率在病程短于6个月组高于病程长于6个月组组(X2=7.935,P=0.005);基底细胞液化程度高分组中的IFN-γ阳性表达率高于低分组(X2=9.070,P=0.011).结论 IL-12可能通过促进典型Th1型细胞因子IFN-γ的产生参与了OLP病损区的病理损伤过程,在OLP局部病损形成初始阶段起到关键作用.%Objective To investigate the significance of cytokine interleukin-12p40 (IL-12p40) and interferon-γ (IFN-γ) in tissues formation and development of human oral lichen planus (OLP).Methods The tissues of 11 cases of normal oral epithelium and 43 cases of OLP were investigated for the expression of IL-12p40 and IFN-γ proteins by using Envision two-step immunohistochemistry.The correlations between the expressions of these two cytokines,and their clinical and pathological significance in OLP were analyzed.Results 1)IL-12p40 and IFN-γ proteins were up-regulated in OLP comparing with that in normal oral mucosa and there was statistical significance between their difference(P<0.05).2)The percentage of positive IL-l2p40 staining in OLP of IFN-γ positive group was higher than IFN-γ negative group and there was statistical significance between their difference(x2=5.828, P=0.016).A positive correlation was found between IL-12p40 and IFN-γ proteins in OLP(Spearman r=0.357, P=0.019).3)The percentage of positive

  5. Lichen physiology and cell biology

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D.H.

    1985-01-01

    This book presents information on topics relating to mineral element accumulation in bog lichens, nitrogen losses from diazotrophic lichens, influence of automobile exhaust and lead on the oxygen exchange of lichens, temporal variation in lichen element levels, and lead and uranium uptake by lichens. Other topics include the architecture of the concentric bodies in the mycobiont of Peltigera praetextata; multiple enzyme forms in lichens, photosynthesis, water relations multiple enzyme forms in lichens, photosynthesis, water relations and thallus structure of strictaceae lichens; and aspects of carbohydrate metabolism in lichens. The distribution of uranium and companion elements in lichen heath associated with undisturbed uranium deposits in the Canadian Arctic is also discussed.

  6. Lichen simplex chronicus

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000872.htm Lichen simplex chronicus To use the sharing features on this page, please enable JavaScript. Lichen simplex chronicus is a skin condition caused by ...

  7. Lichen substances prevent lichens from nutrient deficiency.

    Science.gov (United States)

    Hauck, Markus; Willenbruch, Karen; Leuschner, Christoph

    2009-01-01

    The dibenzofuran usnic acid, a widespread cortical secondary metabolite produced by lichen-forming fungi, was shown to promote the intracellular uptake of Cu(2+) in two epiphytic lichens, Evernia mesomorpha and Ramalina menziesii, from acidic, nutrient-poor bark. Higher Cu(2+) uptake in the former, which produces the depside divaricatic acid in addition to usnic acid, suggests that this depside promotes Cu(2+) uptake. Since Cu(2+) is one of the rarest micronutrients, promotion of Cu(2+) uptake by lichen substances may be crucial for the studied lichens to survive in their nutrient-poor habitats. In contrast, study of the uptake of other metals in E. mesomorpha revealed that the intracellular uptake of Mn(2+), which regularly exceeds potentially toxic concentrations in leachates of acidic tree bark, was partially inhibited by the lichen substances produced by this species. Inhibition of Mn(2+) uptake by lichen substances previously has been demonstrated in lichens. The uptake of Fe(2+), Fe(3+), Mg(2+), and Zn(2+), which fail to reach toxic concentrations in acidic bark at unpolluted sites, although they are more common than Cu(2+), was not affected by lichen substances of E. mesomorpha.

  8. Lichen endozoochory by snails.

    Science.gov (United States)

    Boch, Steffen; Prati, Daniel; Werth, Silke; Rüetschi, Jörg; Fischer, Markus

    2011-04-13

    Endozoochory plays a prominent role for the dispersal of seed plants. However, for most other plant taxa it is not known whether this mode of dispersal occurs at all. Among those other taxa, lichens as symbiotic associations of algae and fungi are peculiar as their successful dispersal requires movement of propagules that leaves the symbiosis functional. However, the potential for endozoochorous dispersal of lichen fragments has been completely overlooked. We fed sterile thalli of two foliose lichen species (Lobaria pulmonaria and Physcia adscendens) differing in habitat and air-quality requirements to nine snail species common in temperate Europe. We demonstrated morphologically that L. pulmonaria regenerated from 29.0% of all 379 fecal pellets, whereas P. adscendens regenerated from 40.9% of all 433 fecal pellets, showing that lichen fragments survived gut passage of all snail species. Moreover, molecular analysis of regenerated lichens confirmed the species identity for a subset of samples. Regeneration rates were higher for the generalist lichen species P. adscendens than for the specialist lichen species L. pulmonaria. Furthermore, lichen regeneration rates varied among snail species with higher rates after gut passage of heavier snail species. We suggest that gastropods generally grazing on lichen communities are important, but so far completely overlooked, as vectors for lichen dispersal. This opens new ecological perspectives and questions the traditional view of an entirely antagonistic relationship between gastropods and lichens.

  9. Biopharmaceutical potential of lichens.

    Science.gov (United States)

    Zambare, Vasudeo P; Christopher, Lew P

    2012-06-01

    Lichens are composite organisms consisting of a symbiotic association of a fungus (the mycobiont) with a photosynthetic partner (the phytobiont), usually either a green alga or cyanobacterium. The morphology, physiology and biochemistry of lichens are very different from those of the isolated fungus and alga in culture. Lichens occur in some of the most extreme environments on the Earth and may be useful to scientists in many commercial applications. Over the past 2 decades, there has been a renewed and growing interest in lichens as a source of novel, pharmacologically active biomolecules. This review summarizes the past and current research and development trends in the characterization and use of lichens and their bioactive compounds in traditional medicine and other biopharmaceutical applications of commercial interest. The present review contains 10 illustrations and 188 references compiled from major databases including Science Direct, Chemical Abstracts, PubMed and Directory of Open Access Journals. Lichen morphology, symbiosis, diversity and bioactivities including enzyme inhibitory, antimicrobial, antifungal, antiviral, anticancer, anti-insecticidal and antioxidant actions were reviewed and summarized. Recent progress in lichens and lichen-forming fungi was discussed with emphasis on their potential to accelerate commercialization of lichen-based products. Lichens are an untapped source of biological activities of industrial importance and their potential is yet to be fully explored and utilized. Lichen-derived bioactive compounds hold great promise for biopharmaceutical applications as antimicrobial, antioxidant and cytotoxic agents and in the development of new formulations or technologies for the benefit of human life.

  10. Lichen secondary metabolites affect growth of Physcomitrella patens by allelopathy.

    Science.gov (United States)

    Goga, Michal; Antreich, Sebastian J; Bačkor, Martin; Weckwerth, Wolfram; Lang, Ingeborg

    2017-05-01

    Lichen secondary metabolites can function as allelochemicals and affect the development and growth of neighboring bryophytes, fungi, vascular plants, microorganisms, and even other lichens. Lichen overgrowth on bryophytes is frequently observed in nature even though mosses grow faster than lichens, but there is still little information on the interactions between lichens and bryophytes.In the present study, we used extracts from six lichen thalli containing secondary metabolites like usnic acid, protocetraric acid, atranorin, lecanoric acid, nortistic acid, and thamnolic acid. To observe the influence of these metabolites on bryophytes, the moss Physcomitrella patens was cultivated for 5 weeks under laboratory conditions and treated with lichen extracts. Toxicity of natural mixtures of secondary metabolites was tested at three selected doses (0.001, 0.01, and 0.1 %). When the mixture contained substantial amounts of usnic acid, we observed growth inhibition of protonemata and reduced development of gametophores. Significant differences in cell lengths and widths were also noticed. Furthermore, usnic acid had a strong effect on cell division in protonemata suggesting a strong impact on the early stages of bryophyte development by allelochemicals contained in the lichen secondary metabolites.Biological activities of lichen secondary metabolites were confirmed in several studies such as antiviral, antibacterial, antitumor, antiherbivore, antioxidant, antipyretic, and analgetic action or photoprotection. This work aimed to expand the knowledge on allelopathic effects on bryophyte growth.

  11. Lichen conservation in heavily managed boreal forests.

    Science.gov (United States)

    McMullin, Richard Troy; Thompson, Ian D; Newmaster, Steven G

    2013-10-01

    Lichens are an important component of the boreal forest, where they are long lived, tend to accumulate in older stands, and are a major food source for the threatened woodland caribou (Rangifer tarandus caribou). To be fully sustainable, silvicultural practices in the boreal forest must include the conservation of ecological integrity. Dominant forest management practices, however, have short-term negative effects on lichen diversity, particularly the application of herbicides. To better understand the long-term effects of forest management, we examined lichen regeneration in 35 mixed black spruce (Picea mariana) and jack pine (Pinus banksiana) forest stands across northern Ontario to determine recovery following logging and postharvest silvicultural practices. Our forest stands were 25-40 years old and had undergone 3 common sivilcultural treatments that included harvested and planted; harvested, planted, and treated with N-[phosphonomethyl] glycine (glyphosate); and harvested, planted, and treated with 2,4-dichlorophenoxyacetic acid (2,4-D). Forest stands with herbicide treatments had lower lichen biomass and higher beta and gamma diversity than planted stands that were not treated chemically or control stands. In northwestern Ontario, planted stands that were not treated chemically had significantly greater (p < 0.05) alpha diversity than stands treated with herbicides or control stands. Our results show that common silvicultural practices do not emulate natural disturbances caused by wildfires in the boreal forest for the lichen community. We suggest a reduction in the amount of chemical application be considered in areas where lichen biomass is likely to be high and where the recovery of woodland caribou is an objective. © 2013 Society for Conservation Biology.

  12. Lichens as Bioindicators

    Science.gov (United States)

    Smith, Gregory L.; Baker, Thomas R.

    2003-01-01

    Lichens, small and unobtrusive organisms, are seldom noticed as they cling to rocks, trees, and soil in fragile veils or crusts of splendid color and ornate textures. Their beauty is captivating and fascinating, and their purpose and origins are thought-provoking. Lichens make particularly good "bioindicators". They are bioindicators of sulfur…

  13. Lichens in the Churchyard

    Science.gov (United States)

    Oldershaw, Cally; Hilton, Barbara; Rocca, Alis

    2010-01-01

    The late Tom Chester, in his role as the British Lichen Society churchyard coordinator, did a great deal to encourage the use of the churchyard as an educational tool. In his honour, the Society has created an award as part of its "Lichen Project". When the Society approached the Association for Science Education (ASE) for help in…

  14. Lichens as Bioindicators

    Science.gov (United States)

    Smith, Gregory L.; Baker, Thomas R.

    2003-01-01

    Lichens, small and unobtrusive organisms, are seldom noticed as they cling to rocks, trees, and soil in fragile veils or crusts of splendid color and ornate textures. Their beauty is captivating and fascinating, and their purpose and origins are thought-provoking. Lichens make particularly good "bioindicators". They are bioindicators of sulfur…

  15. Lichens in the Churchyard

    Science.gov (United States)

    Oldershaw, Cally; Hilton, Barbara; Rocca, Alis

    2010-01-01

    The late Tom Chester, in his role as the British Lichen Society churchyard coordinator, did a great deal to encourage the use of the churchyard as an educational tool. In his honour, the Society has created an award as part of its "Lichen Project". When the Society approached the Association for Science Education (ASE) for help in…

  16. Exploiting the Lichen Liaison.

    Science.gov (United States)

    Raham, R. Gary

    1978-01-01

    For teachers in search of an easily obtainable, readily dissectable, and unique living specimen to arouse the interest of their students and illustrate important biological principles, lichens are the perfect selection. Background information and experiments on lichen anatomy, physiology, and chemistry are given. An appendix gives culture media.…

  17. Experimental and Clinical Evaluation of Plantago australis Extract as an Anti-Inflammatory Agent to Treat Oral Pathologies

    Directory of Open Access Journals (Sweden)

    Flores

    2016-09-01

    Full Text Available Background Plantago australis is a native plant from Southern Brazil used to reduce inflammation. Interestingly, there are no previous studies evaluating its use to treat oral lesions. Objectives The study aimed to investigate in vivo the anti-inflammatory activity of 10% ethanol extract of P. australis in recurrent aphthous stomatitis (RAS, erosive lichen planus (ELP and actinic cheilitis (AC. Methods Thirty patients with RAS, ELP and AC were treated topically with 10% P. australis solution-based or cream. Results In the comparison of in vivo data before and after the treatment and between different lesions, all P values were less than 0.05. Conclusions The pharmaceutical formulation of 10% P. australis was therapeutically effective in the subjects with inflammatory oral lesions of RAS, ELP and AC.

  18. Líquen estriado no adulto Lichen striatus on adult

    Directory of Open Access Journals (Sweden)

    Leticia Fogagnolo

    2011-02-01

    Full Text Available Líquen estriado é uma erupção inflamatória incomum, de etiologia desconhecida. Raramente acomete adultos, e é caracterizada pelo surgimento abrupto de pápulas coalescentes, em arranjo linear, usualmente em extremidades. A histopatologia mostra reação liquenóide envolvendo folículos e glândulas. Ocasionalmente há sobreposição com líquen plano linear e "blaschkitis", seus principais diagnósticos diferenciais. Relata-se um caso de mulher adulta com pápulas eritematovioláceas em região cervical e hemiface direitas, cuja correlação clínico-histopatológica permitiu o diagnóstico de líquen estriado. Os achados atípicos e a dificuldade diagnóstica são discutidos.Lichen Striatus is an uncommon inflammatory skin eruption of unknown etiology. It rarely affects adults, and it is characterized by abrupt onset of coalescent papules, in a linear disposition, usually on the extremities. Histopathology shows lichenoid reaction involving follicles and glands. Occasionally, there is overlap with linear lichen planus and "blaschkitis", the main differential diagnoses. It is reported here the case of an adult woman with erythematous violaceous papules on the right side of the neck and face, diagnosed with lichen striatus by clinical and histopathological correlation. The atypical findings and the diagnostic difficulty are discussed.

  19. Learning about Lichens.

    Science.gov (United States)

    McKenzie, Danny

    1982-01-01

    Provides background information and teaching suggestions for collecting and using lichens in the classroom and for conducting field investigations. Focuses on structure, reproduction, photosynthesis, and effects of air pollution. (DC)

  20. Learning about Lichens.

    Science.gov (United States)

    McKenzie, Danny

    1982-01-01

    Provides background information and teaching suggestions for collecting and using lichens in the classroom and for conducting field investigations. Focuses on structure, reproduction, photosynthesis, and effects of air pollution. (DC)

  1. Biomonitoring with lichens on twigs

    DEFF Research Database (Denmark)

    Vilsholm, René Larsen; Wolseley, Pat; Søchting, Ulrik

    2009-01-01

    Two surveys of the lichen and bryophyte flora growing on oak twigs from a Welsh and a Danish locality were compared with additional data on bark pH and % nitrogen in thalli of Hypogymnia physodes. Despite differences in climate and lichen flora, both sites showed a shift in the lichen communities...

  2. Phytase activity in lichens.

    Science.gov (United States)

    Higgins, Niall F; Crittenden, Peter D

    2015-10-01

    Phytase activity was investigated in 13 lichen species using a novel assay method. The work tested the hypothesis that phytase is a component of the suite of surface-bound lichen enzymes that hydrolyse simple organic forms of phosphorus (P) and nitrogen (N) deposited onto the thallus surface. Hydrolysis of inositol hexaphosphate (InsP6 , the substrate for phytase) and appearance of lower-order inositol phosphates (InsP5 -InsP1 ), the hydrolysis products, were measured by ion chromatography. Phytase activity in Evernia prunastri was compared among locations with contrasting rates of N deposition. Phytase activity was readily measurable in epiphytic lichens (e.g. 11.3 μmol InsP6 hydrolysed g(-1)  h(-1) in Bryoria fuscescens) but low in two terricolous species tested (Cladonia portentosa and Peltigera membranacea). Phytase and phosphomonoesterase activities were positively correlated amongst species. In E. prunastri both enzyme activities were promoted by N enrichment and phytase activity was readily released into thallus washings. InsP6 was not detected in tree canopy throughfall but was present in pollen leachate. Capacity to hydrolyse InsP6 appears widespread amongst lichens potentially promoting P capture from atmospheric deposits and plant leachates, and P cycling in forest canopies. The enzyme assay used here might find wider application in studies on plant root-fungal-soil systems.

  3. Study of Some Lichens of Qatar

    OpenAIRE

    2011-01-01

    The desert regions of North and central Qatar were surveyed for lichens. Twelve species were reported. The most common lichens are of the crustose type and all fungi of the lichens collected are Ascomycete.

  4. Lichen compounds restrain lichen feeding by bank voles (Myodes glareolus).

    Science.gov (United States)

    Nybakken, Line; Helmersen, Anne-Marit; Gauslaa, Yngvar; Selås, Vidar

    2010-03-01

    Some lichen compounds are known to deter feeding by invertebrate herbivores. We attempted to quantify the deterring efficiency of lichen compounds against a generalist vertebrate, the bank vole (Myodes glareolus). In two separate experiments, caged bank voles had the choice to feed on lichens with natural or reduced concentrations of secondary compounds. We rinsed air-dry intact lichens in 100% acetone to remove extracellular compounds non-destructively. In the first experiment, pairs of control and rinsed lichen thalli were hydrated and offered to the bank voles. Because the lichens desiccated fast, we ran a second experiment with pairs of ground control and compound-deficient thalli, each mixed with water to porridge. Eight and six lichen species were tested in the first and second experiment, respectively. In the first, bank voles preferred compound-deficient thalli of Cladonia stellaris and Lobaria pulmonaria, but did not discriminate between the other thallus pairs. This was likely a result of deterring levels of usnic and stictic acid in the control thalli. When lichens were served as porridge, significant preference was found for acetone-rinsed pieces of Cladonia arbuscula, C. rangiferina, Platismatia glauca, and Evernia prunastri. The increased preference was caused mainly by lower consumption of control thalli. Grinding and mixing of thallus structures prevented bank voles from selecting thallus parts with lower concentration of secondary compounds and/or strengthened their deterring capacity. We conclude that some lichen secondary compounds deter feeding by bank voles.

  5. Anticancer activities of selected species of North American lichen extracts.

    Science.gov (United States)

    Shrestha, Gajendra; El-Naggar, Atif M; St Clair, Larry L; O'Neill, Kim L

    2015-01-01

    Cancer is the second leading cause of human deaths in the USA. Despite continuous efforts to treat cancer over the past 50 years, human mortality rates have not decreased significantly. Natural products, such as lichens, have been good sources of anticancer drugs. This study reports the cytotoxic activity of crude extracts of 17 lichen species against Burkitt's lymphoma (Raji) cells. Out of the 17 lichen species, extracts from 14 species showed cytotoxicity against Raji cells. On the basis of IC50 values, we selected Xanthoparmelia chlorochroa and Tuckermannopsis ciliaris to study the mechanism of cell death. Viability of normal lymphocytes was not affected by the extracts of X. chlorochroa and T. ciliaris. We found that extracts from both lichens decreased proliferation, accumulated cells at the G0 /G1 stage, and caused apoptosis in a dose-dependent manner. Both lichen extracts also caused upregulation of p53. The T. ciliaris extract upregulated the expression of TK1 but X. chlorochroa did not. We also found that usnic, salazinic, constictic, and norstictic acids were present in the extract of X. chlorochroa, whereas protolichesterinic acid in T. ciliaris extracts. Our data demonstrate that lichen extracts merit further research as a potential source of anticancer drugs.

  6. Photodynamic therapy in the treatment of vulvar lichen sclerosus.

    Science.gov (United States)

    Maździarz, Agnieszka; Osuch, Beata; Kowalska, Magdalena; Nalewczyńska, Agnieszka; Śpiewankiewicz, Beata

    2017-09-01

    Vulvar lichen sclerosus is a chronic and incurable disease that causes various unpleasant symptoms and serious consequences. The purpose of the study was to assess the effectiveness of photodynamic therapy in the treatment of vulvar lichen sclerosus. Participants in the study included 102 female patients aged 19-85 suffer from vulvar lichen sclerosus. The patients underwent photodynamic therapy (PDT). In the course of PDT the 5% 5- aminolevulinic acid was used in gel form. The affected areas were irradiated with a halogenic lamp PhotoDyn 501 (590-760nm) during a 10-min radiation treatment. The treatment was repeated weekly for 10 weeks. PDT has brought about a good therapeutic effect (complete or partial clinical remission), with 87.25% improvement rate in patients suffering from lichen sclerosus. The greatest vulvoscopic response was observed in the reduction of subepithelial ecchymoses and teleangiectasia (78.95%), and the reduction of erosions and fissures (70.97%). A partial remission of lichenification with hyperkeratosis was observed in 51.61% of cases. The least response was observed in the atrophic lesions reduction (improvement in 37.36% of cases). Our patients suffering from vulvar lichen sclerosus demonstrated positive responses to photodynamic therapy and the treatment was well tolerated. Photodynamic therapy used to treat lichen sclerosus yields excellent cosmetic results. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Lichenoid Sarcoidosis Resembling Lichen Scrofulosorum

    OpenAIRE

    Thami Gurvinder P; Kanwar Amrinder J

    1998-01-01

    An old man with lichenoid popular lesions, dyspnoea and bilateral hilar lymphadenopathy resembling lichen scrofulosorum diagnosed as lichenoid sarcofulosorum and therapeutic response to corticosteroids is discussed.

  8. Extensive bullous lichen sclerosus et atrophicus*

    Science.gov (United States)

    Vukicevic, Jelica

    2016-01-01

    Lichen sclerosus et atrophicus is a chronic disease of unknown etiology characterized by atrophic and sclerotic plaques in both genital and extragenital regions. Extensive bullous lichen sclerosus et atrophicus (BLSA) is a severe variant of the disease with no widely accepted treatment. We present a 63-year-old woman with extensive extragenital, ivory-colored, atrophic plaques on her trunk and extremities and disseminated hemorrhagic bullae. The patient was unsuccessfully treated with standard topical corticosteroid therapy, doxycycline and chloroquine. According to the literature, there is little evidence of the efficacy of doxycycline and hydroxychloroquine in the treatment of BLSA. We report a rare case of extensive BLSA that is unresponsive to these drugs.

  9. LICHEN STRIATUS – CASE REPORTS

    Directory of Open Access Journals (Sweden)

    Caius Solovan

    2013-07-01

    Full Text Available Lichen striatus is an acquired linear inflammatory dermatosis, not frequently reported, with a peculiar clinical aspect, most often described in adults, with a poor response to treatment. We described 4 cases of lichen striatus diagnosed over an 8-month period of time.

  10. The Significance of Lichens and Their Metabolites

    Science.gov (United States)

    Huneck, S.

    Lichens, symbiontic organisms of fungi and algae, synthesize numerous metabolites, the "lichen substances," which comprise aliphatic, cycloaliphatic, aromatic, and terpenic compounds. Lichens and their metabolites have a manifold biological activity: antiviral, antibiotic, antitumor, allergenic, plant growth inhibitory, antiherbivore, and enzyme inhibitory. Usnic acid, a very active lichen substance is used in pharmaceutical preparations. Large amounts of Pseudevernia furfuracea and Evernia prunastri are processed in the perfume industry, and some lichens are sensitive reagents for the evaluation of air pollution.

  11. Lignin phenols derivatives in lichens.

    Science.gov (United States)

    Zavarzina, A G; Romankevich, E A; Peresypkin, V I; Ulyantzev, A S; Belyaev, N A; Zavarzin, A A

    2015-01-01

    Lignin monophenols have been measured in the cupric oxide oxidation products from lichens of different systematic groups. It is shown for the first time that syringyl structures in most lichens strongly dominate over vanillyl and p-hydroxyl ones (S/V 7-583, S/P 3-30). This distinguishes lichens from algae and mosses (p-hydroxyl phenols are dominant) and from higher plants (S/V ratios are from 0 in gymnosperms to 1.1-5.2 in angiosperms). Molecular ratios of phenols as well as the ratios of acids to aldehydes in lichens were different from lignin of higher plants, suggesting contribution of non-lignin phenols in CuO oxidation products. The contents of syringyl and vanillyl phenols in some lichen species were comparable to non-woody tissues of higher plants. Results of the study suggest that lichens can be important source of aromatic structures in soils and hydrosphere, particularly in the regions were lichens are abundant.

  12. Metabolism of 4-chlorobiphenyl by lichens.

    Science.gov (United States)

    Maass, W S; Hutzinger, O

    Eighteen lichens from a variety of habitats were treated with 4-chlorobiphenyl (4-CB). All, as determined by means of radioactive tracers, were shown to partially convert 4-CB to 4-chloro-4'-hydroxybiphenyl. Only one species (Pseudocyphellaria crocata) produced a further major metabolite not previously reported, namely 4-chloro-4'-methoxybiphenyl. The formation of the hydroxyderivative by Cladonia rangiferina and Lasallia papulosa was proven by isolation and chemical identification. Difficulties in the recovery of both the starting material and the metabolites from Pseudocyphellaria were encountered.

  13. Is grandma like a lichen planus? The problem of image perception and knowledge retention in pathology

    Science.gov (United States)

    Mello-Thoms, Claudia; Legowski, Elizabeth; Tseytlin, Eugene

    2013-03-01

    Medicine is the science of acquiring a lot of obscure knowledge and the art of knowing when to apply it, even if only once in a physician's lifetime. Although medical experts seem to have it all figured out, being significantly better and faster than trainees, many studies have suggested that it is not only the amount of knowledge - which comes with experience - that differentiates the experts, but it is also how the knowledge is structured in memory. To acquire new knowledge, trainees will first encode both `surface' (i.e., irrelevant) and `structural' (relevant) features, and repeated presentations of the material will allow for dismissal of the unimportant elements from memory. However, just because knowledge has been encoded it does not mean that it is safely guarded in the physician's memory; as with any information, if it is not tended to, it will slowly decay, and eventually it may be completely forgotten. In this study we investigated knowledge retention in a specific sub-domain of Pathology which is rarely, if ever, used by trainees. We wanted to determine the relationship between the way long-term memory is accessed (i.e., through recognition or free recall) and trainee performance. We also sought to determine whether access to long-term memory through either mechanism led to better transfer of newly acquired knowledge to never before seen cases.

  14. [Oral squamous cell carcinoma and lichen planus vs. lichenoid lesions. Case report].

    Science.gov (United States)

    Esquivel-Pedraza, Lilly; Fernández-Cuevas, Laura; Ruelas-Villavicencio, Ana Lilia; Guerrero-Ramos, Brenda; Hernández-Salazar, Amparo; Milke-García, María Pilar; Méndez-Flores, Silvia

    2016-01-01

    Introducción: el desarrollo de carcinoma escamocelular a partir del liquen plano bucal es controversial. Describimos un caso con carcinoma escamocelular intrabucal, que cursa con lesiones de liquen plano bucal y se analizan las dificultades para distinguir los cambios incipientes del carcinoma escamocelular de las lesiones por liquen plano intrabucales que lleven a establecer un diagnóstico certero de ambas entidades. Caso clínico: hombre de 57 años, con antecedente de tabaquismo y hábito alcohólico crónico, que presenta lesión tumoral ulcerada en borde lateral izquierdo de lengua y placas blancas reticulares bilaterales en mucosa yugal, bordes laterales y vientre de lengua. El reporte histopatológico fue de carcinoma escamocelular invasor moderadamente diferenciado y liquen plano respectivamente. Conclusiones: la naturaleza premaligna del liquen plano bucal es controvertida, esto por inconsistencia en los criterios diagnóstico clínicos e histológicos que permitan diferenciar los casos de liquen plano bucal de otras lesiones como las reacciones liquenoides o displasias intraepiteliales con alto potencial de malignización. Posiblemente las reacciones liquenoides bucales tienen un mayor riesgo de transformación maligna al compararse con el clásico liquen plano bucal.

  15. Lycopene in the management of oral lichen planus: A placebo-controlled study

    Directory of Open Access Journals (Sweden)

    Nisheeth Saawarn

    2011-01-01

    Settings and Design: This prospective, randomized, double-blind, placebo-controlled study was done in the Oral Medicine Department of a postgraduate teaching dental hospital in India. Materials and Methods: Thirty symptomatic OLP patients, randomly divided into two groups of 15 each, were administered lycopene 8 mg/day and an identical placebo, respectively, for 8 consecutive weeks. Burning sensation using visual analogue scale and overall treatment response using Tel Aviv-San Francisco scale were recorded at every visit. The data obtained were analyzed statistically using Wilcoxon Rank test, Mann-Whitney and Fischer′s Exact test. Results: A higher (84% reduction in burning sensation was seen in lycopene than in the placebo group (67%. All 15 (100% patients in the lycopene group showed 50% or more benefit and 11 (73.3% patients showed 70-100% benefit, while this number was only 10 and 4 (26.7%, respectively, in the placebo group. Conclusion: Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis.

  16. Foxp3 gene expression in oral lichen planus: A clinicopathological study

    National Research Council Canada - National Science Library

    LEI, LEI; ZHAN, LIHUA; TAN, WEIXIA; CHEN, SHAOHUA; LI, YANGQIU; REYNOLDS, MARK

    2014-01-01

    ...). The present study aimed to investigate Foxp3 expression in CD4+CD25+ T cells of peripheral blood mononuclear cells and oral lesions in patients diagnosed with OLP, who were grouped as OLP subtype, duration and relapse...

  17. Maxillary sinus carcinoma in a patient with oral lichen planus: A case report

    OpenAIRE

    L.J. Grando; Fabro, S. M.; Da Silva Rath, Inês Beatriz; M.I. Meurer; F.I. Daniel; Teixeira, G. V.; Somacarrera Pérez, María Luisa

    2013-01-01

    Mujer de 55 años de edad, fumadora, depresiva, con Liquen Plano Oral (LPO) de control clínico difícil, de más de 10 años de evolución. La paciente ha presentado períodos de remisión y exacerbación de las lesiones, de forma paralela presentó aumento de volumen intraoral en región maxilar izquierda, la superficie de la nueva lesión estaba ulcerada, y desprendía olor fétido en región alveolar sometida a exodoncias previas. El diagnóstico clínico inicial fue de una probable transforma...

  18. Allelic imbalance in oral lichen planus and assessment of its classification as a premalignant condition

    Science.gov (United States)

    Accurso, Brent T.; Warner, Blake M.; Knobloch, Thomas J.; Weghorst, Christopher M.; Shumway, Brian S.; Allen, Carl M.; Kalmar, John R.

    2012-01-01

    OLP is a relatively common immune-mediated mucosal condition with a predilection for middle-aged women. Although classified as a premalignant condition, this classification remains controversial. Using stringent diagnostic criteria, some authors have found that OLP patients are not at increased risk for oral SCC. Credible but limited genetic evidence also indicates that epithelial tissues from OLP patients diagnosed using stringent criteria differs from premalignant or malignant oral lesions but is similar to epithelium from benign oral lesions. To further investigate this genetic line of evidence, biopsy specimens diagnosed as fibroma, OLP, low-grade dysplasia, high-grade dysplasia, and SCC were retrieved from the archives of the Oral Pathology Consultants at the Ohio State University. Using laser capture microdissection, tissue of interest was captured from each case and DNA subsequently extracted. Fluorescently labeled PCR primers were used to amplify DNA at 3 tumor suppressor gene loci (3p14.2, 9p21, and 17p13) and evaluated for LOH or microsatellite instability (MSI). OLP was found to be significantly different from low-grade dysplasia, high-grade dysplasia, and SCC when LOH/MSI was found at more than 1 loci (P = .011, P = .032, P = .003), but not different from benign fibromas (P = .395). In agreement with previous studies, well-documented cases of OLP diagnosed using stringent criteria exhibit a genetic profile more similar to a benign or reactive process than a premalignant/malignant one. These findings do not support the classification of OLP as a premalignant condition. PMID:21764610

  19. Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis

    DEFF Research Database (Denmark)

    Larsen, Kristine Roen; Johansen, Jeanne Duus; Reibel, Jesper

    2017-01-01

    salivary concentration of total protein and sIgA than cases without contact allergy and healthy controls. METHODS: Forty-nine patients (42 women, aged 61.0 ± 10.3 years) and 29 healthy age- and gender-matched subjects underwent a standardised questionnaire on general and oral health, assessment......, but not associated with salivary gland hypofunction, numbers of systemic diseases or medications, contact allergy, age, or gender. Salivary sIgA levels were higher in patients than in healthy controls, but did not differ between patient groups. The total salivary protein concentration was lower in unstimulated...... in patients (46.9%) than in healthy controls, whereas the saliva flow rates did not differ. The patients had higher sIgA levels in unstimulated and chewing-stimulated saliva than the healthy controls. The total protein concentration in saliva was lower in the unstimulated saliva samples whereas it was higher...

  20. Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis

    DEFF Research Database (Denmark)

    Larsen, Kristine Røn; Johansen, Jeanne Duus; Reibel, Jesper

    2017-01-01

    salivary concentration of total protein and sIgA than cases without contact allergy and healthy controls. Methods: 49 patients (42 women, aged 61.0±10.3 years) and 29 healthy age- and gender-matched subjects underwent a standardised questionnaire on general and oral health, assessment of xerostomia......, but not associated with salivary gland hypofunction, numbers of systemic diseases or medications, contact allergy, age, or gender. Salivary sIgA levels were higher in patients than in healthy controls, but did not differ between patient groups. The total salivary protein concentration was lower in unstimulated.......9%) than in healthy controls, whereas the saliva flow rates did not differ. The patients had higher sIgA levels in unstimulated and chewing-stimulated saliva than the healthy controls. The total protein concentration in saliva was lower in the unstimulated saliva samples whereas it was higher...

  1. Exploring symbiont management in lichens.

    Science.gov (United States)

    Grube, Martin; Spribille, Toby

    2012-07-01

    Lichens are unique among fungal symbioses in that their mycelial structures are compact and exposed to the light as thallus structures. The myriad intersections of unique fungal species with photosynthetic partner organisms (green algae in 90% of lichens) produce a wide variety of diverse shapes and colours of the fully synthesized lichen thallus when growing in nature. This characteristic complex morphology is, however, not achieved in the fungal axenic state. Even under ideal environmental conditions, the lichen life cycle faces considerable odds: first, meiotic spores are only produced on well-established thalli and often only after achieving considerable age in a stable environment, and second, even then in vivo resynthesis requires the presence of compatible algal strains where fungal spores germinate. Many lichen species have evolved a way around the resynthesis bottleneck by producing asexual propagules for joint propagation of symbionts. These different dispersal strategies ostensibly shape the population genetic structure of lichen symbioses, but the relative contributions of vertical (joint) and horizontal (independent) symbiont transmission have long eluded lichen evolutionary biologists. In this issue of Molecular Ecology, Dal Grande et al. (2012) close in on this question with the lung lichen, Lobaria pulmonaria, a flagship species in the conservation of old growth forests. By capitalizing on available microsatellite markers for both fungal and algal symbionts, they show that while vertical transmission is the predominant mode of reproduction, horizontal transmission is demonstrable and actively shapes population genetic structure. The resulting mixed propagation system is a highly successful balance of safe recruitment of symbiotic clones and endless possibilities for fungal recombination and symbiont shuffling.

  2. Lichen simplex chronicus on the ankle (image)

    Science.gov (United States)

    Lichen simplex chronicus on the ankle: Lichen simplex chronicus is also known as neurodermatitis. A minor itch may encourage scratching which increases the irritation, leading to more scratching. This ...

  3. Liver function and immunoglobulins in skin lichen palnus

    Directory of Open Access Journals (Sweden)

    Sharma P

    1990-01-01

    Full Text Available Fifty-two patients of skin lichen planus conforming to the clinical and histopathological description were subjected to the different liver function tests. Age and sex matched clinically normal equal number of persons were taken as controls to exclude liver disorders.] Seven (13.46% of the patients used to consume mild to moderate amount of alcohol. Nine (17.30% cases gave the history of jaundice in the past and all of them had hepatomegaly. Otherwise hepatomegaly was observed in 37 (71.15% cases. None of the healthy controls had hepatomegaly. Aspartase iminotransferase (AST alanine aminotransferase (ALT and alkaline phosphatase was raised in 11 (21.15%, 4 (7.69% and 10 (19.23% cases respectively. HBsAg was not detected in any of the 52 patients.The most contradictory finding was the revelation of raised immunoglo bulin of G, A or M either singly or in different combinations. IgG and IgA were raised in 32 (61.53% cases while IgM in 26 (50.0%.

  4. THE LICHENS OF NORTH CENTRAL OKLAHOMA

    Directory of Open Access Journals (Sweden)

    DARVIN WENDELL KECK

    2006-12-01

    Full Text Available Over 1,000 specimens of lichens were collected at 78 collecting stations in 11 counties of North Central Oklahoma during 1959 and 1960. The objectives were to identify lichens collected in the area; to establish a record of lichen distribution for each county in the area; and to analyze the ecological relationships.

  5. Bacterial communities associated with the lichen symbiosis.

    Science.gov (United States)

    Bates, Scott T; Cropsey, Garrett W G; Caporaso, J Gregory; Knight, Rob; Fierer, Noah

    2011-02-01

    Lichens are commonly described as a mutualistic symbiosis between fungi and "algae" (Chlorophyta or Cyanobacteria); however, they also have internal bacterial communities. Recent research suggests that lichen-associated microbes are an integral component of lichen thalli and that the classical view of this symbiotic relationship should be expanded to include bacteria. However, we still have a limited understanding of the phylogenetic structure of these communities and their variability across lichen species. To address these knowledge gaps, we used bar-coded pyrosequencing to survey the bacterial communities associated with lichens. Bacterial sequences obtained from four lichen species at multiple locations on rock outcrops suggested that each lichen species harbored a distinct community and that all communities were dominated by Alphaproteobacteria. Across all samples, we recovered numerous bacterial phylotypes that were closely related to sequences isolated from lichens in prior investigations, including those from a lichen-associated Rhizobiales lineage (LAR1; putative N(2) fixers). LAR1-related phylotypes were relatively abundant and were found in all four lichen species, and many sequences closely related to other known N(2) fixers (e.g., Azospirillum, Bradyrhizobium, and Frankia) were recovered. Our findings confirm the presence of highly structured bacterial communities within lichens and provide additional evidence that these bacteria may serve distinct functional roles within lichen symbioses.

  6. Lichens as environmental risk detectors

    Science.gov (United States)

    Caridi, F.; D'Agostino, M.; Messina, M.; Marcianò, G.; Grioli, L.; Belvedere, A.; Marguccio, S.; Belmusto, G.

    2017-04-01

    Several studies carried out after the Chernobyl nuclear accident in 1986 showed that lichens are suitable biomonitors of the fall-out, given their long life expectancy. 137Cs activity concentrations were measured through HPGe gamma spectrometry in different epiphytic lichens ( Usnea SPP, Platismatia glauca, Pseudevernia furfuracea, Ramalina SPP), collected from three sampling sites in the Calabria region, south of Italy. Data on variations in the contents of airborne particulates heavy metals, As, Be, Cd, Cu, Hg, Pb and Zn, measured in the thalli of the investigated lichens through inductively coupled plasma mass spectrometry (ICP-MS), were reported in accordance with a lichen thalli naturalness/alteration scale. Energy-dispersive X-ray microanalysis in a scanning electron microscope (SEM-EDX), with an electron beam of 20keV, that interacts with the sample leading to the emission of characteristic X-rays as secondary radiation, was also employed to investigate about the chemistry of the adherent particles to the surface of investigated lichens and about the possible interaction between them and the surrounding environment. Data obtained in this article provide useful information on the environmental risk of the studied area and can be further used for a radiological and chemical mapping.

  7. Xanthones of Lichen Source: A 2016 Update.

    Science.gov (United States)

    Le Pogam, Pierre; Boustie, Joël

    2016-03-02

    An update of xanthones encountered in lichens is proposed as more than 20 new xanthones have been described since the publication of the compendium of lichen metabolites by Huneck and Yoshimura in 1996. The last decades witnessed major advances regarding the elucidation of biosynthetic schemes leading to these fascinating compounds, accounting for the unique substitution patterns of a very vast majority of lichen xanthones. Besides a comprehensive analysis of the structures of xanthones described in lichens, their bioactivities and the emerging analytical strategies used to pinpoint them within lichens are presented here together with physico-chemical properties (including NMR data) as reported since 1996.

  8. Xanthones of Lichen Source: A 2016 Update

    Directory of Open Access Journals (Sweden)

    Pierre Le Pogam

    2016-03-01

    Full Text Available An update of xanthones encountered in lichens is proposed as more than 20 new xanthones have been described since the publication of the compendium of lichen metabolites by Huneck and Yoshimura in 1996. The last decades witnessed major advances regarding the elucidation of biosynthetic schemes leading to these fascinating compounds, accounting for the unique substitution patterns of a very vast majority of lichen xanthones. Besides a comprehensive analysis of the structures of xanthones described in lichens, their bioactivities and the emerging analytical strategies used to pinpoint them within lichens are presented here together with physico-chemical properties (including NMR data as reported since 1996.

  9. Water isotopes in desiccating lichens

    Science.gov (United States)

    Cuntz, Matthias; Máguas, Cristina; Lakatos, Michael

    2009-01-01

    The stable isotopic composition of water is routinely used as a tracer to study water exchange processes in vascular plants and ecosystems. To date, no study has focussed on isotope processes in non-vascular, poikilohydric organisms such as lichens and bryophytes. To understand basic isotope exchange processes of non-vascular plants, thallus water isotopic composition was studied in various green-algal lichens exposed to desiccation. The study indicates that lichens equilibrate with the isotopic composition of surrounding water vapour. A model was developed as a proof of concept that accounts for the specific water relations of these poikilohydric organisms. The approach incorporates first their variable thallus water potential and second a compartmentation of the thallus water into two isotopically distinct but connected water pools. Moreover, the results represent first steps towards the development of poikilohydric organisms as a recorder of ambient vapour isotopic composition. PMID:19888598

  10. Ammonium and nitrate tolerance in lichens.

    Science.gov (United States)

    Hauck, Markus

    2010-05-01

    Since lichens lack roots and take up water, solutes and gases over the entire thallus surface, these organisms respond more sensitively to changes in atmospheric purity than vascular plants. After centuries where effects of sulphur dioxide and acidity were in the focus of research on atmospheric chemistry and lichens, recently the globally increased levels of ammonia and nitrate increasingly affect lichen vegetation and gave rise to intense research on the tolerance of lichens to nitrogen pollution. The present paper discusses the main findings on the uptake of ammonia and nitrate in the lichen symbiosis and to the tolerance of lichens to eutrophication. Ammonia and nitrate are both efficiently taken up under ambient conditions. The tolerance to high nitrogen levels depends, among others, on the capability of the photobiont to provide sufficient amounts of carbon skeletons for ammonia assimilation. Lowly productive lichens are apparently predisposed to be sensitive to excess nitrogen.

  11. High Life Expectancy of Bacteria on Lichens.

    Science.gov (United States)

    Cernava, Tomislav; Berg, Gabriele; Grube, Martin

    2016-10-01

    Self-sustaining lichen symbioses potentially can become very old, sometimes even thousands of years in nature. In the joint structures, algal partners are sheltered between fungal structures that are externally colonized by bacterial communities. With this arrangement lichens survive long periods of drought, and lichen thalli can be revitalized even after decades of dry storage in a herbarium. To study the effects of long-term ex situ storage on viability of indigenous bacterial communities we comparatively studied herbarium-stored material of the lung lichen, Lobaria pulmonaria. We discovered that a significant fraction of the lichen-associated bacterial community survives herbarium storage of nearly 80 years, and living bacteria can still be found in even older material. As the bacteria reside in the upper surface layers of the lichen material, we argue that the extracellular polysaccharides of lichens contribute to superior life expectancy of bacteria. Deeper understanding of underlying mechanisms could provide novel possibilities for biotechnological applications.

  12. Clinical recommendation: pediatric lichen sclerosus.

    Science.gov (United States)

    Bercaw-Pratt, Jennifer L; Boardman, Lori A; Simms-Cendan, Judith S

    2014-04-01

    Lichen sclerosus is a chronic inflammatory condition affecting the anogenital region that may present in the prepubertal or adolescent patient. Clinical presentations include significant pruritus, labial adhesions, and loss of pigmentation. Treatment includes topical anti-inflammatory agents and long-term follow-up as there is a high risk of recurrence and an increased risk of vulvar cancer in adult women with history of lichen sclerosus. These recommendations are intended for pediatricians, gynecologists, nurse practitioners and others who care for pediatric/adolescent girls in order to facilitate diagnosis and treatment.

  13. Pes Planus and Pediatric Obesity: A Systematic Review of the Literature

    Science.gov (United States)

    Stolzman, Stacy; Irby, Megan B.; Callahan, Allison B.; Skelton, Joseph A.

    2015-01-01

    Children with obesity report musculoskeletal pain more than normal weight children; this may be linked with literature suggesting children with obesity have higher prevalence of pes planus (flatfoot). To further elucidate whether this relation occurs, we conducted a systematic literature review on the co-occurrence of pes planus and pediatric obesity. Empirical articles published through September 2013 were obtained through an electronic search of MEDLINE and SportDiscus; included articles examined the association between bodyweight and pes planus in children. Thirteen cross-sectional studies of varied designs were identified. Methods used to diagnose pes planus varied between studies: imaging modalities, anthropometric measurements, and clinical examination. Across all studies, pes planus prevalence among children with obesity ranged widely from 14 to 67%. Nearly all studies indicated increasing pes planus in children with increasing weight. No studies evaluated pain/complications related to pes planus. Our review suggests increased prevalence of pes planus among children with obesity or increasing weight status. Due to differing methodologies, lack of consensus regarding the pes planus definition, the dearth of investigation into pain/complications, and the few existing studies, more research is needed to determine a relation between children’s body weight, pes planus, and associated effects on pain and function. PMID:25808780

  14. Response of the nitrogen-fixing lichen Lobaria pulmonaria to phosphorus, molybdenum, and vanadium

    Science.gov (United States)

    Marks, Jade A; Pett-Ridge, Julie; Perakis, Steven S.; Allen, Jessica L; McCune, Bruce

    2015-01-01

    Nitrogen-fixing lichens (cyanolichens) are an important source of nitrogen (N) in Pacific Northwest forests, but limitation of lichen growth by elements essential for N fixation is poorly understood. To investigate how nutrient limitation may affect cyanolichen growth rates, we fertilized a tripartite cyanobacterial lichen (Lobaria pulmonaria) and a green algal non-nitrogen fixing lichen (Usnea longissima) with the micronutrients molybdenum (Mo) and vanadium (V), both known cofactors for enzymes involved in N fixation, and the macronutrient phosphorus (P). We then grew treated lichens in the field for one year in western Oregon, USA. Lichen growth was very rapid for both species and did not differ across treatments, despite a previous demonstration of P-limitation in L. pulmonaria at a nearby location. To reconcile these disparate findings, we analyzed P, Mo, and V concentrations, natural abundance δ15N isotopes, %N and change in thallus N in Lobaria pulmonaria from both growth experiments. Nitrogen levels in deposition and in lichens could not explain the large difference in growth or P limitation observed between the two studies. Instead, we provide evidence that local differences in P availability may have caused site-specific responses of Lobaria to P fertilization. In the previous experiment, Lobaria had low background levels of P, and treatment with P more than doubled growth. In contrast, Lobaria from the current experiment had much higher background P concentrations, similar to P-treated lichens in the previous experiment, consistent with the idea that ambient variation in P availability influences the degree of P limitation in cyanolichens. We conclude that insufficient P, Mo, and V did not limit the growth of either cyanolichens or chlorolichens at the site of the current experiment. Our findings point to the need to understand landscape-scale variation in P availability to cyanolichens, and its effect on spatial patterns of cyanolichen nutrient

  15. Reflectance spectra of subarctic lichens

    Science.gov (United States)

    Petzold, Donald E.; Goward, Samuel N.

    1988-01-01

    Lichens constitute a major portion of the ground cover of high latitude environments, but little has been reported concerning their in situ solar spectral reflectance properties. Knowledge of these properties is important for the interpretation of remotely sensed observations from high latitude regions, as well as in studies of high latitude ecology and energy balance climatology. The spectral reflectance of common boreal vascular plants is similar to that of vascular plants of the midlatitudes. The dominant lichens, in contrast, display variable reflectance patterns in visible wavelengths. The relative reflectance peak at 0.55 microns, common to green vegetation, is absent or indistinct in spectra of pervasive boreal forest and tundra lichens, despite the presence of chlorophyll in the inner algal cells. Lichens of the dominant genus, Cladina, display strong absorption of ultraviolet energy and short-wavelength blue light relative to their absorption in other visible wavelengths. Since the Cladinae dominate both the surface vegetation in open woodlands of the boreal forest and the low arctic tundra, their unusual spectral reflectance patterns will enable accurate monitoring of the boreal forest-tundra ecotone and detection of its vigor and movement in the future.

  16. Dermatology case: segmental lichen aureus

    OpenAIRE

    Fernandes, I.; S. Carvalho; Machado, S.; Alves,R.; Selores, M.

    2012-01-01

    ABSTRACT The authors describe a clinical case of a six-year-old boy with history of a segmental brownish maculopapular skin eruption on his left thoracic and lumbar wall, since the last four months. Based on clinical and histological findings he was diagnosed with segmental lichen aureus.

  17. Innovative Approaches Using Lichen Enriched Media to Improve Isolation and Culturability of Lichen Associated Bacteria

    National Research Council Canada - National Science Library

    Biosca, Elena G; Flores, Raquel; Santander, Ricardo D; Díez-Gil, José Luis; Barreno, Eva

    2016-01-01

    ... and for the description of new taxa. Our objective was to improve the recovery of lichen associated bacteria by developing novel isolation and culture approaches, initially using the lichen Pseudevernia...

  18. Innovative Approaches Using Lichen Enriched Media to Improve Isolation and Culturability of Lichen Associated Bacteria

    OpenAIRE

    Biosca, Elena G.; Flores, Raquel; Ricardo D Santander; D?ez-Gil, Jos? Luis; Barreno, Eva

    2016-01-01

    Lichens, self-supporting mutualistic associations between a fungal partner and one or more photosynthetic partners, also harbor non-photosynthetic bacteria. The diversity and contribution of these bacteria to the functioning of lichen symbiosis have recently begun to be studied, often by culture-independent techniques due to difficulties in their isolation and culture. However, culturing as yet unculturable lichenic bacteria is critical to unravel their potential functional roles in lichen sy...

  19. Fluorine content in epiphtic lichens and mosses

    Energy Technology Data Exchange (ETDEWEB)

    Olech, M.; Kajfosz, J.; Szymczyk, S.; Wodniecki, P.

    1981-01-01

    The fluorine content in epiphytic lichens (Physcia adscendens, Physconia grisea, Parmelia sulcata and Evernia prunastri) and the moss Orthotrichum obtusifolium growing near an aluminum plant is presented. Analyses of lichen samples show the correlation between the distribution of the emitted fluorine and the distance from the source of emission; the most visible effects are in the direction of the prevailing winds. The more resistant lichen species accumulate greater amounts of fluorine than the less resistant ones.

  20. Lichens: unexpected anti-prion agents?

    Science.gov (United States)

    Rodriguez, Cynthia M; Bennett, James P; Johnson, Christopher J

    2012-01-01

    The prion diseases sheep scrapie and cervid chronic wasting disease are transmitted, in part, via an environmental reservoir of infectivity; prions released from infected animals persist in the environment and can cause disease years later. Central to controlling disease transmission is the identification of methods capable of inactivating these agents on the landscape. We have found that certain lichens, common, ubiquitous, symbiotic organisms, possess a serine protease capable of degrading prion protein (PrP) from prion-infected animals. The protease functions against a range of prion strains from various hosts and reduces levels of abnormal PrP by at least two logs. We have now tested more than twenty lichen species from several geographical locations and from various taxa and found that approximately half of these species degrade PrP. Critical next steps include examining the effect of lichens on prion infectivity and cloning the protease responsible for PrP degradation. The impact of lichens on prions in the environment remains unknown. We speculate that lichens could have the potential to degrade prions when they are shed from infected animals onto lichens or into environments where lichens are abundant. In addition, lichens are frequently consumed by cervids and many other animals and the effect of dietary lichens on prion disease transmission should also be considered.