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Sample records for levimusest 5-7 aastastel

  1. Lift conference | 5-7 February

    CERN Multimedia

    2014-01-01

    Since 2006, Lift Events explore the business and social implications of new technologies through the organisation of international event series and open innovation programs in Europe, Asia and America. The next conference will be held on 5-7 February in Geneva.   (Image: © Lift Conference) The Lift Conference is one of the leading conferences on innovation in Europe and a key annual meeting for individuals and organizations wishing to understand and anticipate trends and innovation. Held every year in February in Geneva (5-7 February 2014), the Lift Conference is a three-day event consisting of talks, interactive workshops, exhibitions, and discussions bringing together over 1’000 participants from all society’s sectors and industries in a dynamic and informal environment with the aim to learn, connect, share and leverage innovation opportunities.   Extraordinary speakers will take to the stage at Lift14: Porter Erisman, former VP of Alibaba.com turned...

  2. Dermal Sensitization of 1-Acetyloctahydro-3,5,7-Trinitro-1,3,5,7-Tetrazocine.

    Science.gov (United States)

    1984-08-08

    tetrazocine (SEX) in guinea pigs MATERIALS Test Substance Chemical name: 1-Acetyloctahydro-3,5,7-Trinitro-I,3,5,7- Tetrazocine (SEX) Chemical Abstract Service...exist as a contaminant in P.DX/HMX manufacturing process. The characteristics of SEX are as follows: Chemical Abstract Service Registry No.: 13980-00-2

  3. Synthesis and Fluorescence Properties of 5,7-Diphenylquinoline and 2,5,7-Triphenylquinoline Derived from m-Terphenylamine

    Directory of Open Access Journals (Sweden)

    Hong Wang

    2007-05-01

    Full Text Available Synthesis of 5,7-phenylquinoline from the Skraup reaction of m-terphenyl-amine and glycerol in the presence of acid is reported. Further reaction of 5,7-diphenyl-quinoline with phenyl lithium prepared in situ led to the formation of 2,5,7-triphenyl-quinoline. All of the products and their intermediates were characterized and the UV-Vis and photo-luminescence (PL spectra of m-terphenylamine, 5,7-diphenylquinoline and 2,5,7-triphenylquinoline are also reported.

  4. Dissociative Electron Attachment to the Nitroamine HMX (Octahydro-1,3,5,7-Tetranitro-1,3,5,7-Tetrazocine)

    National Research Council Canada - National Science Library

    Postler, Johannes; Goulart, Marcelo M; Matias, Carolina; Mauracher, Andreas; da Silva, Filipe Ferreira; Scheier, Paul; Limão-Vieira, Paulo; Denifl, Stephan

    2013-01-01

    In the present study, dissociative electron attachment (DEA) measurements with gas phase HMX, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine, C4H8N8O8, have been performed by means of a crossed electron-molecular beam experiment...

  5. Primary Dermal Irritation of 1-Acetyloctahydro-3,5,7-Trinitro-1,3,5,7-Tetrazine.

    Science.gov (United States)

    1983-06-01

    Tetrazine Chemical Abstract 3ervice F ;istry V" 139800-00-2 Lewis--2 Structural formula: C-CH3 H C N-NO2 02 N-N H2 H4X-N Empirical formula: C6H11N7...CHEMICAL DATA Chemical name: 1-Acetyloctahydro-3,5,7-Trinitro-1,3,5,7-Tetrazine Chemical Abstract Service Registry No.: 139800-00-2 Structural formula

  6. Psychiatric disorders in Danish children aged 5-7 years

    DEFF Research Database (Denmark)

    Elberling, Hanne; Linneberg, Allan; Ulrikka Rask, Charlotte

    2016-01-01

    preschool to school. METHODS: A sample of 1585 children from the Copenhagen Child Cohort, CCC2000 aged 5-7 years was assessed using the Development and Well-Being Assessment (DAWBA) with diagnostic classification by experienced clinicians. Perinatal, sociodemographic and socio-economic data was obtained......BACKGROUND: Knowledge about the presentation of psychopathology in preschool age and associated risk factors is fundamental to preventive intervention before schooling. AIMS: To investigate the full spectrum of psychiatric diagnoses in general population children at the period of transition from...... from Danish national registries. RESULTS: The prevalence of any ICD-10 psychiatric disorder was 5.7% (95%CI: 4.4-7.1). Pervasive developmental disorders (PDD) were found in 1.3% (95%CI: 0.8-1.8) and behavioural and hyperkinetic disorders were found in 1.5% (95%CI: 0.9-2.1) and 1.0% (95%CI: 0...

  7. Effects of 5,7-dihydroxytriptamine (5,7-DHT on circadian locomotor activity of the blow fly, Calliphora vicina

    Directory of Open Access Journals (Sweden)

    Bronislaw Cymborowski

    2003-05-01

    Full Text Available The biogenic amine serotonin (5-HT is a neuromodulator in both vertebrates and invertebrates. It has been shown that serotonin, apart from its distinct effects on behavior, also plays a morphoregulatory role during the ontogeny of the insect's nervous system. The role of serotonin in modulating circadian locomotor activity of the blow fly, Calliphora vicina was explored. Injection of a specific neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT, into the hemolymph appeared to significantly reduced the level of locomotor activity and lengthened the period (tau of circadian rhythmicity. After drug injection in constant darkness flies continued with their free-running rhythm of a locomotor activity, depending on the time of 5,7-DHT injection. This compound causes phase delay when administered in the early subjective day, and phase advance in the late subjective day. This effect is the opposite of the phase response curve obtained for 5-HT injections. This suggests that 5-HT might act as an entraining agent via the output pathway by feedback to clock neurons in the brain. Some of the injected insects regained their normal level of activity after a few days. These findings suggest a potential role for serotonin as modulator of circadian rhythms in insect including regulation of the level of locomotor activity.

  8. Dissociative Electron Attachment to the Nitroamine HMX (Octahydro-1,3,5,7-Tetranitro-1,3,5,7-Tetrazocine)

    CERN Document Server

    Postler, J; Matias, C; Mauracher, A; da Silva, F Ferreira; Scheier, P; Limão-Vieira, P; Denifl, S

    2016-01-01

    In the present study, dissociative electron attachment (DEA) measurements with gas phase HMX, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine, $C_4H_8N_8O_8$, have been performed by means of a crossed electron-molecular beam experiment. The most intense signals are observed at 46 and 176u and assigned to $NO_{2}^{-}$ and $C_3H_6N_5O_{4}^{-}$, respectively. Anion efficiency curves for 15 negatively charged fragments have been measured in the electron energy region from about 0-20 eV with an energy resolution of ~0.7 eV. Product anions are observed mainly in the low energy region, near 0 eV, arising from surprisingly complex reactions associated with multiple bond cleavages and structural and electronic rearrangement. The remarkable instability of HMX towards electron attachment with virtually zero kinetic energy reflects the highly explosive nature of this compound. Substantially different intensity ratios of resonances for common fragment anions allow distinguishing the nitroamines HMX and royal demolition e...

  9. Preparation and Properties of 1, 3, 5, 7-Tetranitro-1, 3, 5, 7-Tetrazocane-based Nanocomposites

    Directory of Open Access Journals (Sweden)

    Xiaofeng Shi

    2015-04-01

    Full Text Available A new insensitive explosive based on octahydro-1, 3, 5, 7-tetranitro-1, 3, 5, 7-tetrazocine (HMX was prepared by spray drying using Viton A as a binder. The HMX sample without binder (HMX-1 was obtained by the same spray drying process also. The samples were characterised by Scanning Electron Microscope, and X-ray diffraction. The Differential Scanning Calorimetry and the impact sensitivity of HMX-1 and nanocomposites were also being tested. The nanocomposite morphology was found to be microspherical (1 μm to 7 μm diameter and composed of many tiny particles, 100 nm to 200 nm in size. The crystal type of HMX-1 and HMX/Viton A agrees with raw HMX. The activation energy of raw HMX, HMX-1 and HMX/Viton A is 523.16 kJ mol-1, 435.74 kJ mol-1 and 482.72 kJ mol-1, respectively. The self-ignition temperatures of raw HMX, HMX-1 and HMX/Viton A is 279.01 °C, 277.63 °C, and 279.34 °C, respectively. The impact sensitivity order of samples is HMX/Viton A < HMX-1 < raw HMX from low to high.Defence Science Journal, Vol. 65, No. 2, March 2015, pp.131-134, DOI:http://dx.doi.org/10.14429/dsj.65.7843

  10. Toxicity of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) in three vertebrate species.

    Science.gov (United States)

    Johnson, Mark S; McFarland, Craig A; Bazar, Matthew A; Quinn, Michael J; LaFiandra, Emily May; Talent, Larry G

    2010-04-01

    The explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine or high-melting explosive (HMX), has been found in soils in areas used for testing and training by the military. Many of these areas contain habitat for valued wildlife species. In an effort to better understand the environmental consequences from exposure, a reptilian (western fence lizard [Sceloporus occidentalis]), an amphibian (red-backed salamander [Plethodon cinereus]), and a mammalian species (rabbit [Oryctolagus cuniculus]) were exposed to HMX under controlled laboratory conditions. Lizards and rabbits were exposed to HMX by way of corn oil through gavage, and salamanders were exposed to HMX in soil. Two deaths occurred from acute oral exposures to lizards to 5000 mg HMX/kg BW. Histological and gross pathologic assessment suggested gut impaction as a possible cause of death. Salamanders exposed to concentrations of HMX in soil 24 h after oral exposures. An LD(50) for rabbits was calculated as 93 mg/kg (95% confidence interval 76-117). A subacute 14-day testing regime found a lowest observed effect level of 10 mg/kg-d and a no observed adverse effect level of 5 mg/kg-d based on hyperkinesia and seizure incidence, although changes suggesting functional hepatic alterations were also found. These data suggest that physiologic differences between species, particularly in gastrointestinal structure and function, can affect the absorption of HMX and hence lead to marked differences in toxicity from exposure to the same compound.

  11. Acute Oral Toxicity of 1-Acetyloctahydro-3,5,7-Trinitro-1,3,5,7-Tetrazocine (Sex) in Male and Female Rats.

    Science.gov (United States)

    1984-05-01

    flame proof cabinet at room temperature. %.. White--2 Chemical name: 1-Acetyloctahydro-3,5,7-Trinitro-1,3,5,7-Tetrazocine Chemical Abstract Service...Trinitrocyclotetramethylenetetramine Chemical Abstract Service Registry No.: 13980-00-2 Structural formula: 0 11 C-CH 0 2 N-N CH2 HC-N NO 2 , Empirical formula: C6H1

  12. 31 CFR 5.7 - When will Treasury entities compromise a Treasury debt?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false When will Treasury entities compromise a Treasury debt? 5.7 Section 5.7 Money and Finance: Treasury Office of the Secretary of the Treasury TREASURY DEBT COLLECTION Procedures To Collect Treasury Debts § 5.7 When will Treasury...

  13. 41 CFR 302-5.7 - Who may travel on a househunting trip at Government expense?

    Science.gov (United States)

    2010-07-01

    ... househunting trip at Government expense? 302-5.7 Section 302-5.7 Public Contracts and Property Management... SUBSISTENCE AND TRANSPORTATION EXPENSES 5-ALLOWANCE FOR HOUSEHUNTING TRIP EXPENSES Employee's Allowance For Househunting Trip Expenses § 302-5.7 Who may travel on a househunting trip at Government expense? Only you and...

  14. A 5,7-dimethoxyflavone/hydroxypropyl-β-cyclodextrin inclusion complex with anti-butyrylcholinesterase activity.

    Science.gov (United States)

    Songngam, Supachai; Sukwattanasinitt, Mongkol; Siralertmukul, Krisana; Sawasdee, Pattara

    2014-10-01

    This study aimed to improve the water solubility of 5,7-dimethoxyflavone (5,7-DMF) isolated from Kaempferia parviflora by complexation with 2-hydroxypropyl-β-cyclodextrin (HPβ-CD). The phase solubility profile of 5,7-DMF in the presence of HPβ-CD was classified as AL-type and indicated a 1:1 mole ratio. Differential scanning colorimetry, X-ray diffraction, NMR and SEM analyses supported the formation of a 5,7-DMF/HPβ-CD inclusion complex involving the A ring of 5,7-DMF inside the HPβ-CD cavity. This is the first example of CD inclusion with the A ring of non-hydroxyl flavones. The stability and binding constants of the complexes were determined using the phase solubility and UV-vis absorption spectroscopy, respectively. The water solubility of 5,7-DMF was increased 361.8-fold by complexation with HPβ-CD and overcame the precipitation problem observed in aqueous buffers, such as during in vitro anti-butyrylcholinesterase activity assays. The 1:1 mole ratio of the 5,7-DMF/HPβ-CD complex showed a 2.7-fold higher butyrylcholinesterase inhibitory activity (in terms of the IC50 value) compared to the non-complexed compound.

  15. Infancy predictors of hyperkinetic and pervasive developmental disorders at ages 5-7 years

    DEFF Research Database (Denmark)

    Elberling, Hanne; Linneberg, Allan; Olsen, Else Marie

    2014-01-01

    birth to age 10 months. Data on the perinatal period were obtained from Danish National Registers. Mental health outcome at age 5-7 years was investigated in 1,585 children who were assessed by the Developmental and Well-Being Assessment (DAWBA) and diagnosed according to the ICD-10. RESULTS: Predictors.......20 (95% CI: 1.55-17.47). No significant infancy predictors were found regarding emotional and behavioural disorders at age 5-7 years. CONCLUSION: Predictors of autism spectrum/pervasive developmental disorders and hyperkinetic disorders at child age 5-7 years were identified between birth and child age...

  16. Performance of mesophilic anaerobic granules for removal of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) from aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    An Chunjiang [Department of Environmental Engineering, Xi' an Jiaotong University, Xi' an 710049 (China); Faculty of Engineering and Applied Science, University of Regina, Regina, Saskatchewan, S4S 0A2 (Canada); He Yanling [Department of Environmental Engineering, Xi' an Jiaotong University, Xi' an 710049 (China); Huang Guohe, E-mail: gordon.huang@uregina.ca [Faculty of Engineering and Applied Science, University of Regina, Regina, Saskatchewan, S4S 0A2 (Canada); Sino-Canada Research Academy of Energy and Environmental Studies, North China Electric Power University, Beijing 102206 (China); Liu Yonghong [Department of Environmental and Chemical Engineering, Xi' an Polytechnic University, Xi' an 710048 (China)

    2010-07-15

    The performance of mesophilic anaerobic granules to degrade octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) was investigated under various conditions. The results of batch experiments showed that anaerobic granules were capable of removing HMX from aqueous solution with high efficiency. Both biotic and abiotic mechanisms contributed to the removal of HMX by anaerobic granules under mesophilic conditions. Adsorption appeared to play a significant role in the abiotic process. Furthermore, HMX could be biodegraded by anaerobic granules as the sole substrate. After 16 days of incubation, 99.04% and 96.42% of total HMX could be removed by 1 g VSS/L acclimated and unacclimated granules, respectively. Vancomycin, an inhibitor of acetogenic bacteria, caused a significant inhibition of HMX biotransformation, while 2-bromoethanesulfonic acid, an inhibitor of methanogenic bacteria, only resulted in a slight decrease of metabolic activity. The presence of the glucose, as a suitable electron donor and carbon source, was found to enhance the degradation of HMX by anaerobic granules. Our study showed that sulfate had little adverse effects on biotransformation of HMX by anaerobic granules. However, nitrate had significant inhibitory effect on the extent of HMX removal especially in the initial period. This study offered good prospects of using high-rate anaerobic technology in the treatment of munition wastewater.

  17. Green synthesis in acid water of 5,7,3’,4’-O-tetramethylquercetin

    Directory of Open Access Journals (Sweden)

    Zhong-lei WANG

    2014-04-01

    Full Text Available Objective: To synthesize 5,7,3′,4′-O-tetramethylrutin. Methods: With absolute N,N-dimethylformamide as the solvent, rutin and methyl iodide were stirring reaction at room temperature for 48h in the presence of potassium carbonate to obtain 5,7,3′,4′-O-tetramethylrutin, after filtering, rinsing with acetone and concentration under reduced pressure. The concentrate was heated and refluxed for about 1h in 0.50% hydrochloric acid, and then cooled and filtered. The precipitation was washed to neutral with distilled water. Results: The synthesis of 5,7,3′,4′-O-tetramethylquercetin was achieved through the steps above, and it has the same anti-influenza virus effect with oseltamivir, the yield was 92.2%. Conclusion: This method owns the characteristics of high yield, simple process, stable and feasible.

  18. Lyman Alpha Emitters at Redshift 5.7 in the COSMOS Field

    CERN Document Server

    Murayama, T; Scoville, N Z; Ajiki, M; Sanders, D B; Mobasher, B; Aussel, H; Capak, P; Koekemoer, A; Shioya, Y; Nagao, T; Carilli, C; Ellis, Richard S; Garilli, B; Giavalisco, M; Kitzbichler, M G; LeFevre, O; MacCagni, D; Schinnerer, E; Smolcic, V; Tribiano, S; Cimatti, A; Komiyama, Yu; Miyazaki, S; Sasaki, S S; Koda, J; Karoji, H

    2007-01-01

    We present results from a narrow-band optical survey of a contiguous area of 1.95 deg^2, covered by the Cosmic Evolution Survey (COSMOS). Both optical narrow-band (lambda_c = 8150 AA and Delta_lambda = 120 AA) and broad-band (B, V, g', r', i', and z') imaging observations were performed with the Subaru prime-focus camera, Suprime-Cam on the Subaru Telescope. We provide the largest contiguous narrow-band survey, targetting Ly alpha emitters (LAEs) at z~5.7. We find a total of 119 LAE candidates at z~5.7. Over the wide-area covered by this survey, we find no strong evidence for large scale clustering of LAEs. We estimate a star formation rate (SFR) density of ~7*10^-4 M_sun yr^-1 Mpc^-3 for LAEs at z~5.7, and compare it with previous measurements.

  19. Infant behaviors are predictive of functional somatic symptoms at ages 5-7 years

    DEFF Research Database (Denmark)

    Rask, Charlotte Ulrikka; Ørnbøl, Eva; Olsen, Else Marie

    2013-01-01

    OBJECTIVE: To investigate infancy predictors of impairing functional somatic symptoms (FSS) at child ages 5-7 years with a focus on problems with feeding, sleep, and tactile reactivity. STUDY DESIGN: This study is part of a longitudinal birth cohort study, Copenhagen Child Cohort CCC2000. Child...... health, development, and functioning were assessed by community health nurses at 4 home visits from birth to age 10 months. FSS at ages 5-7 years were measured by the Soma Assessment Interview in 1327 children. Sociodemographic data and information on maternal psychiatric illness were obtained from...... of living) predicted impairing FSS at 5-7 years (aOR = 2.9, 95% CI: 1.3-6.6). Maternal psychiatric illness during the child's first year of living was also associated with later child FSS (aOR = 7.1, 95% CI: 1.8-27.8). CONCLUSION: Regulatory problems may be an early marker of disturbed sensory reactivity...

  20. 5,7-二羟基黄酮的合成工艺改进%Synthetic Study on 5,7-dihydroxyflavone

    Institute of Scientific and Technical Information of China (English)

    蔡小华; 胡薇

    2004-01-01

    间苯三酚(2)与乙腈发生Hoesch反应,合成中间体2', 4', 6'-三羟基苯乙酮(3);然后在相转移催化剂TEBA存在下,与苯甲酰氯缩合,得到中间体1-(2', 4', 6'-三羟苯基)-3-苯基-1, 3-丙二酮(4),4不经过分离,一锅法直接重排和关环合成5', 7'-二羟基黄酮(1),总收率为68.4%,比文献提高8%.

  1. Biodegradation of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) by Phanerochaete chrysosporium: new insight into the degradation pathway.

    Science.gov (United States)

    Fournier, Diane; Halasz, Annamaria; Thiboutot, Sonia; Ampleman, Guy; Manno, Dominic; Hawari, Jalal

    2004-08-01

    Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) is a recalcitrant energetic chemical that tends to accumulate in soil, close to the surface. The present study describes the aerobic biodegradability of HMX using Phanerochaete chrysosporium. When added to 7 day old static P. chrysosporium liquid cultures, HMX (600 nmol) degraded within 25 days of incubation. The removal of HMX was concomitant with the formation of transient amounts of its mono-nitroso derivative (1-NO-HMX). The latter apparently degraded via two potential routes: the first involved N-denitration followed by hydrolytic ring cleavage, and the second involved alpha-hydroxylation prior to ring cleavage. The degradation of 1-NO-HMX gave the ring-cleavage product 4-nitro-2,4-diazabutanal (NDAB), nitrite (NO2 -), nitrous oxide (N2O), and formaldehyde (HCHO). Using [14C]-HMX, we obtained 14CO2 (70% in 50 days), representing three C atoms of HMX. Incubation of real soils, contaminated with either HMX (403 micromol kg(-1)) (military base soil) or HMX (3057 micromol kg(-1)), and RDX (342 micromol kg(-1)) (ammunition soil) with the fungus led to 75 and 19.8% mineralization of HMX (liberated 14CO2), respectively, also via the intermediary formation of 1-NO-HMX. Mineralization in the latter soil increased to 35% after the addition of glucose, indicating that a fungus-based remediation process for heavily contaminated soils is promising. The present findings improve our understanding about the degradation pathway of HMX and demonstrate the utility of using the robust and versatile fungus P. chrysosporium to develop effective remediation processes for the removal of HMX.

  2. High dynamic range emission measurements of shocked energetic materials: Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)

    Science.gov (United States)

    Bassett, Will P.; Dlott, Dana D.

    2016-06-01

    A new emission apparatus with high time resolution and high dynamic range was used to study shock-induced ignition of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine in the form of ultrafine powder (4 ± 3 μm particle size), over a range of impact velocities (0.8-4.3 km s-1) and impact durations (2.5-16 ns). A graybody model was used to extract graybody emissivities and time-dependent temperatures from a few ns to 100 μs. The emission transients consisted of three parts: a 6700 K nanosecond burst during the shocks, a 4000-4500 K temperature spike near 0.3 μs followed by a ˜3300 K tail extending out to ˜100 μs. These temperatures varied remarkably little with impact velocity and duration, while the emission intensities and emissivities changed by over an order of magnitude. The emissivity changes were interpreted with a hot spot model, where hot spot temperatures reached a maximum of 6700 K and the hot spot volume fractions increased from 5% to 100% as impact velocity increased from 1 to 3 km s-1. Changing shock durations in the 2.5-16 ns range had noticeable effects on the microsecond emission. The 0.3 μs temperature spike was much smaller or absent with 2.5 ns shocks, but prominent with longer durations. An explanation for these effects was put forth that invoked the formation of carbon-rich clusters during the shock. In this view, cluster formation was minimal with 2.5 ns shocks, but longer-duration shocks produced increasingly larger clusters, and the 0.3 μs temperature spikes represented cluster ignition.

  3. Food Safety Knowledge and Behaviours of Children (5-7 Years)

    Science.gov (United States)

    Eves, Anita; Bielby, Gill; Egan, Bernadette; Lumbers, Margaret; Raats, Monique; Adams, Martin

    2010-01-01

    Objective: The objective of this study was to determine knowledge of food hygiene amongst young children (5-7 years), and facilitators and barriers to application of knowledge. Few studies exist that explore the knowledge and attitudes of young children towards food hygiene. This is an important age group, as it is a time when attitudes and…

  4. Synthesis and antimicrobial activity of 4',5,7-trihydroxy-3'-prenylflavanone

    Indian Academy of Sciences (India)

    Adiana Mohamed Adib; Farediah Ahmad; Muhammad Sum Idris

    2008-09-01

    4',5,7-Trihydroxy-3'-prenylflavanone was synthesized and tested for antibacterial effects against Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The synthesized compounds were characterized using UV, IR, MS and 1H and 13C NMR data. The antibacterial screening of the synthesized compounds were performed in vitro by the filter paper disc diffusion method.

  5. Revisiting the Canterbury earthquake sequence after the 14 February 2016 Mw 5.7 event

    NARCIS (Netherlands)

    Herman, Matthew W.; Furlong, Kevin P.

    2016-01-01

    On 14 February 2016, an Mw 5.7 (GNS Science moment magnitude) earthquake ruptured offshore east of Christchurch, New Zealand. This earthquake occurred in an area that had previously experienced significant seismicity from 2010 to 2012 during the Canterbury earthquake sequence, starting with the 2010

  6. Some Observed Results of Solar Radio Spectrometer at 4.5-7.5 GHz

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A new instrument of broadband solar radio spectrometer working at waveband 4.5-7.5 GHz was developed at Purple Mountain Observatory for Solar Maximum 23. Some new results of spectral observation have been obtained since August 1999. Two typical type Ⅲμ bursts with rich fine structures are presented and some interesting features discussed.

  7. Relaxant mechanisms of 3, 5, 7, 30, 40-pentamethoxyflavone on isolated human cavernosum

    DEFF Research Database (Denmark)

    Jansakul, Chaweewan; Tachanaparuksa, Kuldej; Mulvany, Michael J.

    2012-01-01

    We have investigated effects and mechanisms responsible for the activity of 3, 5, 7, 30, 40-pentamethoxyflavone (PMF) on isolated human cavernosum. PMF is the major flavone isolated from Kaempferia parviflora claimed to act as an aphrodisiac. PMF caused relaxation of phenylephrine precontracted h...

  8. G65.2+5.7: A Thermal Composite Supernova Remnant With a Cool Shell

    CERN Document Server

    Shelton, R L; Petre, R

    2004-01-01

    This paper presents archival ROSAT PSPC observations of the G65.2+5.7 supernova remnant (also known as G65.3+5.7). Little material obscures this remnant and so it was well observed, even at the softest end of ROSAT's bandpass (~0.11 to 0.28 keV). These soft X-ray images reveal the remnant's centrally-filled morphology which, in combination with existing radio frequency observations, places G65.2+5.7 in the thermal composite (mixed morphology) class of supernova remnants. Not only might G65.2+5.7 be the oldest known thermal composite supernova remnant, but owing to its optically revealed cool, dense shell, this remnant supports the proposal that thermal composite supernova remnants lack X-ray bright shells because they have evolved beyond the adiabatic phase. These observations also reveal a slightly extended point source centered on RA = 19h 36m 46s, dec = 30deg 40' 07'' and extending 6.5 arcmin in radius in the band 67 map. The source of this emission has yet to be discovered, as there is no known pulsar at ...

  9. 36 CFR 5.7 - Construction of buildings or other facilities.

    Science.gov (United States)

    2010-07-01

    ... OF THE INTERIOR COMMERCIAL AND PRIVATE OPERATIONS § 5.7 Construction of buildings or other facilities. Constructing or attempting to construct a building, or other structure, boat dock, road, trail, path, or other... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Construction of buildings or...

  10. Computational prediction of probabilistic ignition threshold of pressed granular Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) under shock loading

    Science.gov (United States)

    Kim, Seokpum; Miller, Christopher; Horie, Yasuyuki; Molek, Christopher; Welle, Eric; Zhou, Min

    2016-09-01

    The probabilistic ignition thresholds of pressed granular Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine explosives with average grain sizes between 70 μm and 220 μm are computationally predicted. The prediction uses material microstructure and basic constituent properties and does not involve curve fitting with respect to or prior knowledge of the attributes being predicted. The specific thresholds predicted are James-type relations between the energy flux and energy fluence for given probabilities of ignition. Statistically similar microstructure sample sets are computationally generated and used based on the features of micrographs of materials used in actual experiments. The predicted thresholds are in general agreement with measurements from shock experiments in terms of trends. In particular, it is found that grain size significantly affects the ignition sensitivity of the materials, with smaller sizes leading to lower energy thresholds required for ignition. For example, 50% ignition threshold of the material with an average grain size of 220 μm is approximately 1.4-1.6 times that of the material with an average grain size of 70 μm in terms of energy fluence. The simulations account for the controlled loading of thin-flyer shock experiments with flyer velocities between 1.5 and 4.0 km/s, constituent elasto-viscoplasticity, fracture, post-fracture contact and friction along interfaces, bulk inelastic heating, interfacial frictional heating, and heat conduction. The constitutive behavior of the materials is described using a finite deformation elasto-viscoplastic formulation and the Birch-Murnaghan equation of state. The ignition thresholds are determined via an explicit analysis of the size and temperature states of hotspots in the materials and a hotspot-based ignition criterion. The overall ignition threshold analysis and the microstructure-level hotspot analysis also lead to the definition of a macroscopic ignition parameter (J) and a microscopic

  11. Structure and simulation of a Zundel ion stabilized by 8-hydroxyquinoline-5, 7 disulphonic acid

    Science.gov (United States)

    Venkatakrishnan, Hasthi Annapurna; Venkatakrishnan, Ramaseshan; Pennathur, Anuj Krishnasundar; Pennathur, Gautam

    2016-07-01

    8-hydroxyquinoline-5, 7 disulphonic was synthesized and recrystallized in methanol to strip away molecules of water. The structure of the molecule revealed that Zundel ion was stabilized in the crystal. Ab-initio molecular dynamics simulation was then carried out to understand the dynamics of proton hopping in this complex. During the course of simulation, the Zundel ion coordinates with a water molecule to form an open H7O3+ structure. This transition state structure de-solvated rapidly forming Zundel ion facilitating proton hopping in the first solvation shell. One of the sulphonic acid groups in the 5 or 7 position of the 8-hydroxyquinoline 5,7 disulphonic acid bonds with the Zundel ion favoring the proton to be transferred to the nearby water molecule through the formation of proton defects. The simulation results support the structural diffusion mechanism and that charged complex migrates through the hydrogen bond network.

  12. Synthesis and Biological Evaluation of Novel 5,7-Dichloro-1,3-benzoxazole Derivatives

    Directory of Open Access Journals (Sweden)

    N. D. Jayanna

    2013-01-01

    Full Text Available A new class of 5,7-dichloro-1,3-benzoxazole derivatives 4–11 were synthesized by fusing 5,7-dichloro-2-hydrazino-1,3-benzoxazole 3 nucleus with aliphatic acids, active methylene compounds, and with selected esters to form heterocyclic ring systems like 1,2,4-triazoles, pyrazoles, and triazine moieties. The compound 3 on diazotization reaction affords the tetrazole compound. The synthesized compounds were characterized by 1H NMR, IR, Mass, and 13C NMR spectral data and screened for cytotoxic, antimicrobial, antioxidant, and antilipase activities. The compounds 4, 5, and 8 have shown significant antimicrobial activities, whereas compounds 6 and 8 have been emerged as leading cytotoxic agents. The compounds 9, 10, and 11 were found to be strong enzyme inhibitors.

  13. Evolution of kinetically controlled In-induced surface structure on Si(5 5 7) surface

    Energy Technology Data Exchange (ETDEWEB)

    Chauhan, Amit Kumar Singh [Physics of Energy Harvesting, (CSIR-NPL), Dr. K.S. Krishnan Road, New Delhi 110012 (India); Department of Physics, JMI, New Delhi 110025 (India); Eldose, Nirosh M.; Mishra, Monu [Physics of Energy Harvesting, (CSIR-NPL), Dr. K.S. Krishnan Road, New Delhi 110012 (India); Niazi, Asad; Nair, Lekha [Department of Physics, JMI, New Delhi 110025 (India); Gupta, Govind, E-mail: govind@nplindia.org [Physics of Energy Harvesting, (CSIR-NPL), Dr. K.S. Krishnan Road, New Delhi 110012 (India)

    2014-09-30

    Highlights: • Evolution of In induced superstructures on Si(5 5 7) surface during RT and HT adsorption/desorption process. • Kinetics is governed by substrate temperature which exhibits various growth modes (FM, SK, VB) under different conditions. • Strain relaxation play significant role in the commencement of desorption/rearrangement of atoms. • A consolidated phase diagram of In/Si(5 5 7) interface has been reported with new √3 × √3-R30° and 4 × 1 phases. - Abstract: This paper introduces issue of kinetically controlled and temperature driven superstructural phase transition of Indium (In) on atomically clean high index Si(5 5 7)-7 × 1 surface. Auger electron spectroscopy analysis reveals that at room-temperature (RT) with a controlled incident flux of 0.002 ML/s; In overlayers evolve through the Frank-van der Merwe growth mode and yield a (1 × 1) diffraction pattern for coverage ≥1 ML. For substrate temperature <500°C, growth of In follows Stranski–Krastanov growth mode while for temperature >500°C island growth is observed. On annealing the In/Si(5 5 7) interface in the temperature range 250–340°C, clusters to two dimensional (2D) layer transformation on top of a stable monolayer is predominated. In-situ RT and HT adsorption and thermal desorption phenomena revealed the formation of coverage and temperature dependent thermally stable In induced superstructural phases such as (4 × 1) at 0.5 ML (520°C), (√3 × √3-R30°) at 0.3 ML (560°C) and (7 × 7) at 0.1 ML (580°C). These indium induced superstructures could be utilized as potential substrate for the growth of various exotic 1D/2D structures.

  14. Odd-numbered oxacalix[n]arenes (n = 5, 7): synthesis and solid-state structures.

    Science.gov (United States)

    Van Rossom, Wim; Robeyns, Koen; Ovaere, Magriet; Van Meervelt, Luc; Dehaen, Wim; Maes, Wouter

    2011-01-01

    The critical synthetic access to odd-numbered calix[n]arenes has evidently resulted in less attention for these macrocycles, although specific molecular recognition phenomena have been observed for some of them. A straightforward fragment coupling approach has been designed, applying kinetically controlled nucleophilic aromatic substitution reaction conditions, affording odd-numbered oxacalix[n]arenes (n = 5, 7) selectively in high yields. The solid-state conformational behavior and the oxacalix[n]arene cavity size were explored by single-crystal X-ray diffraction studies.

  15. Meeting report: the Schizophrenia International Research Society (SIRS) South America Conference (August 5-7, 2011).

    Science.gov (United States)

    Massuda, Raffael; Chaves, Cristiano; Trzesniak, Clarissa; Machado-de-Sousa, Joao P; Zanetti, Marcus V; Murray, Robin M; Gattaz, Wagner F; Busatto, Geraldo F

    2012-05-01

    On August 5-7, 2011, São Paulo was home to the first regional meeting of the Schizophrenia International Research Society (SIRS). Over 400 people from many countries attended the activities and contributed with around 200 submissions for oral and poster presentations. This article summarizes the data presented during the meeting, with an emphasis on the plenary talks and sessions for short oral presentations. For information on the poster presentations, readers are referred to the special issue of Revista de Psiquiatria Clínica (Brazil) dedicated to the conference (available at: http://www.hcnet.usp.br/ipq/revista/vol38/s1/).

  16. A z ∼ 5.7 Lyα emission line with an ultrabroad red wing

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Huan; Wang, JunXian [CAS Key Laboratory for Research in Galaxies and Cosmology, Department of Astronomy, University of Science and Technology of China, Hefei, Anhui 230026 (China); Zheng, Zhen-Ya; Malhotra, Sangeeta; Rhoads, James E. [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287 (United States); Infante, Leopoldo, E-mail: yanghuan@mail.ustc.edu.cn, E-mail: jxw@mail.ustc.edu.cn, E-mail: zzheng13@asu.edu, E-mail: smalhotr@asu.edu, E-mail: james.rhoads@asu.edu, E-mail: linfante@astro.puc.cl [Institute of Astrophysics, Ponticia Universidad Catolica, Santiago (Chile)

    2014-03-20

    Using the Lyα emission line as a tracer of high-redshift, star-forming galaxies, hundreds of Lyα emission line galaxies (LAEs) at z > 5 have been detected. These LAEs are considered to be low-mass young galaxies, critical to the re-ionization of the universe and the metal enrichment of the circumgalactic medium (CGM) and the intergalactic medium (IGM). It is assumed that outflows in LAEs can help both ionizing photons and Lyα photons escape from galaxies. However, we still know little about the outflows in high-redshift LAEs due to observational difficulties, especially at redshift >5. Models of Lyα radiative transfer predict asymmetric Lyα line profiles with broad red wings in LAEs with outflows. Here, we report a z ∼ 5.7 Lyα emission line with a broad red wing extending to >1000 km s{sup –1} relative to the peak of Lyα line, which has been detected in only a couple of z > 5 LAEs until now. If the broad red wing is ascribed to gas outflow instead of active galactic nucleus activity, the outflow velocity could be larger than the escape velocity (∼500 km s{sup –1}) of a typical halo mass of z ∼ 5.7 LAEs, which is consistent with the idea that outflows in LAEs disperse metals to CGM and IGM.

  17. Stereoselective Synthesis of Substituted 1,3,5,7,9-Decapentaenes

    Institute of Scientific and Technical Information of China (English)

    CAO Xiaoping; WANG Xiaolong; WANG Feng; YANG Yuying; Liu Dong

    2001-01-01

    @@ Conjugated 1,3,5,7,9-decapentaene is an important structural unit in various of natural products such as phytoene, aurenin, vitamin At and A2[1]. It has been shown that conjugated polyenes are potentially useful compounds for non-linear optical materials. In the meantime the study of well-defined molecules has advanced into a strong field on its own right, because of the promising electronic and optical properties of these compounds[2]. It also attracts the interests of physical chemists as a calculation model[3] during the past decades. In the literature, there are only a few general strategies for the stereocontrolled construction of the decapentaene unit. This is mainly due to the instability and the facile (E)-(Z) isomerization of pentaene system. Synthetic methods for the construction of conjugated decapentaenes relied on the Wittig olefination[4], the Heck coupling reaction[5], the mixed crossed aldol condensation between conjugated esters and aldehydes[6], opening reaction of fulvalene complexes[7]. In our previous studies[8] on stereoseletive synthesis of polyene, we reported that conjugated trienes and enediynes could be prepared by our modified Ramberg-Backlund reaction from corresponding diallylic sulfones and dipropagylic sulfones. This synthetic method was applied to the synthesis of natural products containing a conjugated triene unit such as Galbanolenes. Reported here are our finding that bis-dienylic sulfones when submitted our Ramberg-Backlund conditions, provide decapentaenes in good yield. We use this synthetic method to synthesize 1,3,5,7,9-dec apentaene.

  18. G156.2+5.7: SN 1006's older cousin

    Science.gov (United States)

    Allen, Glenn E.; Pannuti, Thomas; Iwanicki, Allana; Tan, William

    2016-04-01

    We report on the results of an analysis of the hydrodynamic properties of the supernova remnant G156.2+5.7. The models of Truelove and McKee (1999) are constrained by the observed amount of thermal X-ray emission, the measured temperature of the forward-shocked electrons, the inferred location of the reverse shock, and the observed amount of non-radiative Balmer line emission. The results suggest that the remnant is expanding into a low-density environment at a distance of at least 0.6 kpc. We review several clues that suggest the remnant was produced by a Type Ia supernova, which when combined with the other hydrodynamic constraints, implies that G156.2+5.7 is 2.6-15 kyr old, is 0.7-1.7 kpc from Earth (i.e. between Earth and the Perseus arm), and is surrounded by material with a hydrogen density of 0.046-0.075 cm-3. These properties are consistent with the remnant having a low radio surface brightness with a highly-ordered and highly-polarized, tangential magnetic field that is inclined by 60-70 degrees relative to the Galactic plane. However, the inferred density and age are not consistent with the fitted value of the ionization age, which may indicate that the momentum distribution of the electrons is not a Maxwell-Boltzmann distribution, but instead includes a high-energy, non-thermal tail.

  19. Evolution of kinetically controlled In-induced surface structure on Si(5 5 7) surface

    Science.gov (United States)

    Chauhan, Amit Kumar Singh; Eldose, Nirosh M.; Mishra, Monu; Niazi, Asad; Nair, Lekha; Gupta, Govind

    2014-09-01

    This paper introduces issue of kinetically controlled and temperature driven superstructural phase transition of Indium (In) on atomically clean high index Si(5 5 7)-7 × 1 surface. Auger electron spectroscopy analysis reveals that at room-temperature (RT) with a controlled incident flux of 0.002 ML/s; In overlayers evolve through the Frank-van der Merwe growth mode and yield a (1 × 1) diffraction pattern for coverage ≥1 ML. For substrate temperature 500 °C island growth is observed. On annealing the In/Si(5 5 7) interface in the temperature range 250-340 °C, clusters to two dimensional (2D) layer transformation on top of a stable monolayer is predominated. In-situ RT and HT adsorption and thermal desorption phenomena revealed the formation of coverage and temperature dependent thermally stable In induced superstructural phases such as (4 × 1) at 0.5 ML (520 °C), (√3 × √3-R30°) at 0.3 ML (560 °C) and (7 × 7) at 0.1 ML (580 °C). These indium induced superstructures could be utilized as potential substrate for the growth of various exotic 1D/2D structures.

  20. Revisiting the Canterbury earthquake sequence after the 14 February 2016 Mw 5.7 event

    Science.gov (United States)

    Herman, Matthew W.; Furlong, Kevin P.

    2016-07-01

    On 14 February 2016, an Mw 5.7 (GNS Science moment magnitude) earthquake ruptured offshore east of Christchurch, New Zealand. This earthquake occurred in an area that had previously experienced significant seismicity from 2010 to 2012 during the Canterbury earthquake sequence, starting with the 2010 Mw 7.0 Darfield earthquake and including four Mw ~6.0 earthquakes near Christchurch. We determine source parameters for the February 2016 event and its aftershocks, relocate the recent events along with the Canterbury earthquakes, and compute Coulomb stress changes resolved onto the recent events and throughout the greater Christchurch region. Because the February 2016 earthquake occurred close to previous seismicity, the Coulomb stress changes resolved onto its nodal planes are uncertain. However, in the greater Christchurch region, there are areas that remain positively loaded, including beneath the city of Christchurch. The recent earthquake and regional stress changes suggest that faults in these regions may pose a continuing seismic hazard.

  1. Synthesis and Antimicrobial Activity of Bis-4,6-sulfonamidated 5,7-Dinitrobenzofuroxans

    Directory of Open Access Journals (Sweden)

    Irina V. Galkina

    2014-01-01

    Full Text Available A new series of bis-4,6-sulfonamidated 5,7-dinitrbenzofuroxans  7–11 had been synthesized and tested for antimicrobial activity. The structures of new sulfanilamide derivatives were characterized by elemental analysis, IR spectroscopy, and mass spectrometry (MALDITOF. The synthesized compounds were tested for their in vitro antimicrobial activity using the disk diffusion method against Gram-positive bacteria Staphylococcus aureus; the Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis; the fungal strain Aspergillus niger; and the yeast-like pathogenic fungus Candida albicans. Our results indicate that the compounds 7–11 exhibit potent antimicrobial activity. The stability of the compounds was evaluated by TG and DSC methods.

  2. Relaxant mechanisms of 3, 5, 7, 30, 40-pentamethoxyflavone on isolated human cavernosum

    DEFF Research Database (Denmark)

    Jansakul, Chaweewan; Tachanaparuksa, Kuldej; Mulvany, Michael J.

    2012-01-01

    We have investigated effects and mechanisms responsible for the activity of 3, 5, 7, 30, 40-pentamethoxyflavone (PMF) on isolated human cavernosum. PMF is the major flavone isolated from Kaempferia parviflora claimed to act as an aphrodisiac. PMF caused relaxation of phenylephrine precontracted...... did not significantly inhibit the relaxant activity of glyceryltrinitrate or acetylcholine on human cavernosal strips precontracted with phenylephrine. In contrast, sildenafil (phosphodiesterase inhibitor) potentiated the relaxant activity of glyceryl trinitrate but not of acetylcholine. In normal...... of nitric oxide, and had no effect as a KATP- or KCa channel opener, a phosphodiesterase inhibitor, a store-operated Ca2þ channel blocker or a Rho-kinase inhibitor. Therefore, these studies suggest that PMF causes relaxation of human cavernosum through voltagedependent Ca2þ channels and other mechanisms...

  3. 3,5,7-Trimethoxy-2-(4-methoxyphenyl-4H-1-benzopyran-4-one

    Directory of Open Access Journals (Sweden)

    Thammarat Aree

    2009-11-01

    Full Text Available In the title compound, C19H18O6, also known as 3,4′,5,7-tetramethoxyflavone, the dihedral angle between the benzopyran-4-one group and the attached benzene ring is 11.23 (8°. An intramolecular C—H...O hydrogen bond generates an S(6 ring motif. In the crystal, molecules are linked into a two-dimensional network parallel to (0overline{1}1 by intermolecular C—H...O hydrogen bonds, which generate R44(20, R44(12 and R22(14 ring motifs. Adjacent networks interact by π–π interactions between the pyran ring and its methoxyphenyl substituent [centroid–centroid distance = 3.5267 (8 Å].

  4. Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities.

    Science.gov (United States)

    Yenjai, Chavi; Wanich, Suchana; Pitchuanchom, Siripit; Sripanidkulchai, Bungon

    2009-09-01

    5,7-Dimethoxyflavone, a major compound from Kaempferia parviflora, was used as a starting material for structural modification. Seven flavonoid derivatives have been synthesized from this flavone. Two new oxime derivatives 4 and 6 exhibited cytotoxicity against HepG2 cell line with IC50 values of 36.38 and 25.34 microg/mL, respectively, and against T47D cell line with IC50 values of 41.66 and 22.94 microg/mL, respectively. Compound 7 showed cytotoxicity against HepG2 and T47D cell lines with IC50 values of 21.36 and 25.00 microg/mL, respectively. Compounds 6 and 7 showed cytotoxicity nearly equal to the tamoxifen standard. In addition, oxime 6 exhibited antifungal activity against Candida albicans with an IC50 value of 48.98 microg/mL.

  5. Convulsion-related activities of Scutellaria flavones are related to the 5,7-dihydroxyl structures.

    Science.gov (United States)

    Yoon, Seo Young; dela Peña, Ike Campomayor; Shin, Chan Young; Son, Kun Ho; Lee, Yong Soo; Ryu, Jong Hoon; Cheong, Jae Hoon; Ko, Kwang Ho

    2011-06-01

    We screened the major bioactive flavones isolated from Scutellaria baicalensis (baicalin, baicalein and oroxylin A) for their convulsion related activities. In electrogenic response score system and the pentylenetetrazole seizure model, baicalein but not oroxylin A and baicalin exhibited anticonvulsant effects. In vitro studies also revealed that baicalein induced intracellular Cl(-) influx, whereas oroxylin A blocked muscimol- and baicalein-induced intracellular Cl(-) influx. The anticonvulsant effect of baicalein was inhibited by flumazenil, a benzodiazepine(BZD) receptor antagonist. Therefore, anticonvulsive effect of baicalein was mediated by the BZD binding site of GABA(A) receptor. The 5, 7-dihydroxyl group is present in the structure of the three flavones. It is postulated that this group played a key role in inducing convulsion-related activities.

  6. Stereoselective Synthesis of Substituted 1,3,5,7,9-Decapentaenes

    Institute of Scientific and Technical Information of China (English)

    CAO; Xiaoping

    2001-01-01

    Conjugated 1,3,5,7,9-decapentaene is an important structural unit in various of natural products such as phytoene, aurenin, vitamin At and A2[1]. It has been shown that conjugated polyenes are potentially useful compounds for non-linear optical materials. In the meantime the study of well-defined molecules has advanced into a strong field on its own right, because of the promising electronic and optical properties of these compounds[2]. It also attracts the interests of physical chemists as a calculation model[3] during the past decades. In the literature, there are only a few general strategies for the stereocontrolled construction of the decapentaene unit. This is mainly due to the instability and the facile (E)-(Z) isomerization of pentaene system. Synthetic methods for the construction of conjugated decapentaenes relied on the Wittig olefination[4], the Heck coupling reaction[5], the mixed crossed aldol condensation between conjugated esters and aldehydes[6], opening reaction of fulvalene complexes[7]. In our previous studies[8] on stereoseletive synthesis of polyene, we reported that conjugated trienes and enediynes could be prepared by our modified Ramberg-Backlund reaction from corresponding diallylic sulfones and dipropagylic sulfones. This synthetic method was applied to the synthesis of natural products containing a conjugated triene unit such as Galbanolenes. Reported here are our finding that bis-dienylic sulfones when submitted our Ramberg-Backlund conditions, provide decapentaenes in good yield. We use this synthetic method to synthesize 1,3,5,7,9-dec apentaene.……

  7. The November 2011 M5.7 Oklahoma Earthquake: Induced or Triggered?

    Science.gov (United States)

    Sumy, D. F.; Cochran, E. S.; Aminzadeh, F.

    2013-12-01

    On 6 November 2011, a M5.7 right-lateral strike-slip earthquake ruptured a section of the Wilzetta fault that strikes approximately N55E in Prague, Oklahoma. This earthquake was preceded by a right-lateral strike-slip M5.0 foreshock that occurred on 5 November 2011 and followed by a left-lateral strike-slip M5.0 aftershock that occurred on 8 November 2011. Seismicity during the sequence delineates three distinct near-vertical fault planes. The M5.0 foreshock was within several hundred meters of two active, high-volume injection wells, and thus was interpreted as potentially induced by Keranen et al. [2013]. Immediately following the M5.0 foreshock, three temporary seismometers were installed, with additional 44 stations installed after the M5.7 mainshock. These 47 stations recorded thousands of foreshocks and aftershocks that surrounded the three M≥5.0 events. We hypothesize that while the M5.0 foreshock (Event A) is potentially induced by anthropogenic activities, the static stress change imparted by this event triggered the M5.7 mainshock (Event B). To investigate this hypothesis, we calculate the static Coulomb stress change on 110 focal mechanism solutions examined in this study. Many of the focal mechanisms are consistent with the rupture planes defined by the seismicity of Events A and B. However, several of the focal mechanism solutions exhibit dip-slip focal mechanisms and/or are more consistent with the M5.0 aftershock (Event C). Event C occurs on a previously unmapped, east-west striking left-lateral fault plane, which differs substantially from the orientation of Events A and B. The diverse range of focal mechanism solutions suggests complex fault interactions within the Wilzetta fault system. Based on these focal mechanism solutions, we investigate the static stress changes imparted on the aftershocks that result from each of the M≥5.0 earthquakes. We find that the stress change induced by the Event A increases the stress at the hypocentral location

  8. A z ~ 5.7 Ly{\\alpha} Emission Line with an Ultra Broad Red Wing

    CERN Document Server

    Yang, Huan; Zheng, Zhen-Ya; Malhotra, Sangeeta; Rhoads, James E; Infante, Leopoldo

    2014-01-01

    Using Ly{\\alpha} emission line as a tracer of high redshift star forming galaxies, hundreds of Ly{\\alpha} emission line galaxies (LAEs) at z > 5 have been detected. These LAEs are considered to be low mass young galaxies, critical to the reionization of the universe and the metal enrichment of circumgalactic medium (CGM) and intergalactic medium (IGM). It is assumed that outflows in LAEs can help ionizing photons and Ly{\\alpha} photons escape out of galaxies. However we still know little about the outflows in high redshifts LAEs due to observational difficulties, especially at redshift > 5. Models of Ly{\\alpha} radiative transfer predict asymmetric Ly{\\alpha} line profiles with broad red wing in LAEs with outflows. Here we report a z ~ 5.7 Ly{\\alpha} emission line with a broad red wing extending to > 1000 km/s relative to the peak of Ly{\\alpha} line, which has been detected in only a couple of z > 5 LAEs till now. If the broad red wing is ascribed to gas outflow instead of AGN activity, the outflow velocity c...

  9. Tetrakis(5,7-dimethylquinolin-8-olato-κ2N,Ohafnium(IV dimethylformamide disolvate

    Directory of Open Access Journals (Sweden)

    Andreas Roodt

    2011-10-01

    Full Text Available In the title compound, [Hf(C11H10NO4]·2C3H7NO, the HfIV atom is coordinated by four N,O-donating bidentate 5,7-dimethyl-8-quinolinolate (Ox− ligands arranged to give a distorted square-antiprismatic coordination polyhedron. The average Hf—O and Hf—N distances are 2.098 and 2.298 Å, respectively, and the average O—Hf—N bite angle is 70.2°. The crystal packing is controlled by π–π interactions between Ox− ligands of neighbouring molecules, giving rise to a three-dimensional supramolecular grid network. The interplanar distances vary from 3.441 (1 to 3.509 (1 Å, while the centroid–centroid distances vary from 3.688 (2 to 3.759 (12 Å. A non-classical C—H...O hydrogen bond is observed between the complex and one of the solvate molecules.

  10. A Survey of z>5.7 Quasars in the Sloan Digital Sky Survey IV

    DEFF Research Database (Denmark)

    Fan, Xiaohui; Strauss, Michael A.; Richards, Gordon T.

    2005-01-01

    We present the discovery of seven quasars at z>5.7, selected from ~2000 deg^2 of multicolor imaging data of the Sloan Digital Sky Survey (SDSS). The new quasars have redshifts z from 5.79 to 6.13. Five are selected as part of a complete flux-limited sample in the SDSS Northern Galactic Cap; two...... have larger photometric errors and are not part of the complete sample. One of the new quasars, SDSS J1335+3533 (z=5.93), exhibits no emission lines; the 3-sigma limit on the rest-frame equivalent width of Ly alpha+NV line is 5 A. It is the highest redshift lineless quasar known, and could...... be a gravitational lensed galaxy, a BL Lac object or a new type of quasar. Two new z>6 quasars, SDSS 1250+3130 (z=6.13) and SDSS J1137+3549 (z=6.01), show deep Gunn-Peterson absorption gaps in Ly alpha. These gaps are narrower the complete Gunn-Peterson absorption troughs observed among quasars at z>6.2 and do...

  11. Mathematics and reading difficulty subtypes: Minor phonological influences on mathematics for 5-7 year olds

    Directory of Open Access Journals (Sweden)

    Julie Ann eJordan

    2015-03-01

    Full Text Available Linguistic influences in mathematics have previously been explored through subtyping methodology and by taking advantage of the componential nature of mathematics and variations in language requirements that exist across tasks. The present longitudinal investigation aimed to examine the language requirements of mathematical tasks in young children aged 5-7 years. Initially, 256 children were screened for mathematics and reading difficulties using standardised measures. Those scoring at or below the 35th percentile on either dimension were classified as having difficulty. From this screening, 115 children were allocated to each of the MD (n=26, MDRD (n=32, reading difficulty (RD, n=22 and typically achieving (TA, n=35 subtypes. These children were tested at four time points, separated by six monthly intervals, on a battery of seven mathematical tasks. Growth curve analysis indicated that, in contrast to previous research on older children, young children with MD and MDRD had very similar patterns of development on all mathematical tasks. Overall, the subtype comparisons suggested that language played only a minor mediating role in most tasks, and this was secondary in importance to non-verbal skills. Correlational evidence suggested that children from the different subtypes could have been using different mixes of verbal and non-verbal strategies to solve the mathematical problems.

  12. The Final SDSS High-Redshift Quasar Sample of 52 Quasars at z>5.7

    CERN Document Server

    Jiang, Linhua; Fan, Xiaohui; Strauss, Michael A; Banados, Eduardo; Becker, Robert H; Bian, Fuyan; Farnsworth, Kara; Shen, Yue; Wang, Feige; Wang, Ran; Wang, Shu; White, Richard L; Wu, Jin; Wu, Xue-Bing; Yang, Jinyi; Yang, Qian

    2016-01-01

    We present the discovery of nine quasars at $z\\sim6$ identified in the Sloan Digital Sky Survey (SDSS) imaging data. This completes our survey of $z\\sim6$ quasars in the SDSS footprint. Our final sample consists of 52 quasars at $5.7

  13. A Survey of z>5.7 Quasars in the Sloan Digital Sky Survey IV

    DEFF Research Database (Denmark)

    Fan, Xiaohui; Strauss, Michael A.; Richards, Gordon T.;

    2005-01-01

    be a gravitational lensed galaxy, a BL Lac object or a new type of quasar. Two new z>6 quasars, SDSS 1250+3130 (z=6.13) and SDSS J1137+3549 (z=6.01), show deep Gunn-Peterson absorption gaps in Ly alpha. These gaps are narrower the complete Gunn-Peterson absorption troughs observed among quasars at z>6.2 and do......We present the discovery of seven quasars at z>5.7, selected from ~2000 deg^2 of multicolor imaging data of the Sloan Digital Sky Survey (SDSS). The new quasars have redshifts z from 5.79 to 6.13. Five are selected as part of a complete flux-limited sample in the SDSS Northern Galactic Cap; two...... have larger photometric errors and are not part of the complete sample. One of the new quasars, SDSS J1335+3533 (z=5.93), exhibits no emission lines; the 3-sigma limit on the rest-frame equivalent width of Ly alpha+NV line is 5 A. It is the highest redshift lineless quasar known, and could...

  14. Functional somatic symptoms in 5-7 year old children: assessment, prevalence and co-occurrence.

    Science.gov (United States)

    Rask, Charlotte Ulrikka

    2012-11-01

    Medically unexplained or functional somatic symptoms (FSS) in children constitute a major clinical problem. However, research data on FSS in young children are few, and epidemiological studies are hampered by lack of good standardised measures. The present thesis consists of two studies: In study one, we developed two measures to assess FSS in young children. The first measure is a parent interview, the Soma Assessment Interview (SAI), to assess the 1-year prevalence and associated impairment caused by FSS. The interview can be performed by lay interviewers and subsequently rated clinically by physicians. A preliminary validation showed a good agreement on FSS recognition between two clinical raters (kappa = 0.86), a good concurrent validity with independent measures of physical complaints and a good discrimination on the prevalence of FSS between a community sample and clinical samples. The second measure is a systematic medical record review of FSS in paediatric patients: the Medical Record Review for Functional Somatic Symptoms in Children (MRFC). Our findings suggest that the MRFC allows identification of subgroups of paediatric patients with multisymptomatic FSS and long-term and/or impairing FSS and it may prove useful for case finding in clinical and epidemiological research. In study two, we investigated the parent-reported FSS and their impairment in a population-based sample of Danish 5-7-year-old children. We used the SAI as the main measure. Data from 1,327 children from The Copenhagen Child Cohort 2000 were analysed. Impairing symptoms were defined as FSS causing substantial discomfort, impairment of everyday life, absence from daycare or school and/or health care seeking. We found that FSS are common in this age group with a 1-year prevalence of 23.2%. Different pain complaints, i.e. limb pain, abdominal pain and headache, were the most prevalent types of FSS. A subgroup of children with impairing FSS (4.4%) was identified. These children were more

  15. Constraining C iii] Emission in a Sample of Five Luminous z = 5.7 Galaxies

    Science.gov (United States)

    Ding, Jiani; Cai, Zheng; Fan, Xiaohui; Stark, Daniel P.; Bian, Fuyan; Jiang, Linhua; McGreer, Ian D.; Robertson, Brant E.; Siana, Brian

    2017-04-01

    Recent observations have suggested that the C iii]λ 1907/1909 emission lines could be alternative diagnostic lines for galaxies in the reionization epoch. We use the F128N narrowband filter on the Hubble Space Telescope’s (HST) Wide Field Camera 3 (WFC3) to search for C iii] emission in a sample of five galaxies at z = 5.7 in the Subaru Deep Field and the Subaru/XMM-Newton Deep Field. Using the F128N narrowband imaging, together with the broadband imaging, we do not detect C iii] emission for the five galaxies with {J}{AB} ranging from 24.10 to 27.00 in our sample. For the brightest galaxy J132416.13+274411.6 in our sample (z = 5.70, {J}{AB}=24.10), which has a significantly higher signal to noise, we report a C iii] flux of 3.34+/- 1.81× {10}-18 {erg} {{{s}}}-1 {{cm}}-2, which places a stringent 3σ upper limit of 5.43× {10}-18 {erg} {{{s}}}-1 {{cm}}-2 on C iii] flux and 6.57 Å on the C iii] equivalent width. Using the stacked image, we put a 3σ upper limit on the mean C iii] flux of 2.55× {10}-18 {erg} {{{s}}}-1 {{cm}}-2 and a 3σ upper limit on the mean C iii] equivalent width of 4.20 Å for this sample of galaxies at z = 5.70. Combined with strong C iii] detection reported among high-z galaxies in the literature, our observations suggest that the equivalent widths of C iii] from galaxies at z > 5.70 exhibit a wide range of distribution. Our strong limits on C iii] emission could be used as a guide for future observations in the reionization epoch.

  16. Macroseismic intensity investigation of the November 2014, M=5.7, Vrancea (Romania crustal earthquake

    Directory of Open Access Journals (Sweden)

    Angela Petruta Constantin

    2016-11-01

    Full Text Available On November 22, 2014 at 21:14:17 local hour (19:14:17 GMT a  ML=5.7 crustal earthquake occurred in the area of Marasesti city of Vrancea county (Romania - the epicenter was located at north latitude 45.87° and east longitude 27.16°, with a focal depth of 39 km. This earthquake is the main shock of a sequence that started with this and lasted until the end of January. During the sequence, characterized by the absence of foreshocks, a number of 75 earthquakes were recorded in 72 hours, the largest of which occurred in the same day with the main shock, at 22:30 (ML= 3.1. The crustal seismicity of Vrancea seismogenic region is characterized by moderate earthquakes with magnitudes that have not exceeded MW 5.9, this value being assigned to an earthquake that occurred in historical times on March 1, 1894 (Romplus catalogue. Immediately after the 2014 earthquake occurrence, the National Institute for Earth Physics (NIEP sent macroseismic questionnaires in all affected areas, in order to define the macroseismic field of ground shaking. According to macroseismic questionnaires survey, the intensity of epicentral area reached VI MSK, and the seismic event was felt in all the extra-Carpathian area. This earthquake caused general panic and minor to moderate damage to the buildings in the epicentral area and the northeast part of country. The main purpose of this paper is to present the macroseismic map of the earthquake based on the MSK-64 intensity scale.

  17. Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum.

    Science.gov (United States)

    Jansakul, Chaweewan; Tachanaparuksa, Kuldej; Mulvany, Michael J; Sukpondma, Youwapa

    2012-09-15

    We have investigated effects and mechanisms responsible for the activity of 3, 5, 7, 3', 4'-pentamethoxyflavone (PMF) on isolated human cavernosum. PMF is the major flavone isolated from Kaempferia parviflora claimed to act as an aphrodisiac. PMF caused relaxation of phenylephrine precontracted human cavernosal strips, and this effect was slightly inhibited by N(G)-nitro-l-arginine, a nitric oxide synthase inhibitor, but not by ODQ (soluble guanylate cyclase inhibitor), TEA (tetraethylammonium, blocker of voltage-dependent K(+) channels) or glybenclamide (blocker of ATP-dependent K(+) channels). PMF did not significantly inhibit the relaxant activity of glyceryltrinitrate or acetylcholine on human cavernosal strips precontracted with phenylephrine. In contrast, sildenafil (phosphodiesterase inhibitor) potentiated the relaxant activity of glyceryl trinitrate but not of acetylcholine. In normal Krebs solution with nifedipine (blocker of l-type Ca(2+) channels), or in Ca(2+)-free Krebs solution, PMF caused a further inhibition of human cavernosum contracted with phenylephrine. In human cavernosum treated with thapsigargin (inhibitor of sarcoplasmic reticulum Ca(2+)-ATPase) in Ca(2+)-free medium, PMF suppressed the concentration-response curve of human cavernosum to phenylephrine and a further suppression was found when SKF-96365 (a blocker of store-operated Ca(2+) channels and Y-27632 (inhibitor of Rho-kinase)), but not nifedipine, were added sequentially. Thus, PMF had only a weak effect on the release of nitric oxide, and had no effect as a K(ATP)- or K(Ca) channel opener, a phosphodiesterase inhibitor, a store-operated Ca(2+) channel blocker or a Rho-kinase inhibitor. Therefore, these studies suggest that PMF causes relaxation of human cavernosum through voltage-dependent Ca(2+) channels and other mechanisms associated with calcium mobilization. Copyright © 2012 Elsevier B.V. All rights reserved.

  18. Possible mechanisms of vasorelaxation for 5,7-dimethoxyflavone from Kaempferia parviflora in the rat aorta.

    Science.gov (United States)

    Tep-Areenan, Patcharin; Sawasdee, Pattara; Randall, Michael

    2010-10-01

    The present study investigated the vascular effects of 5,7-dimethoxyflavone (DMF), isolated from the rhizomes of Kaempferia parviflora (KP), on rat isolated aortic rings and its possible mechanisms. DMF (1-100 μM) caused concentration-dependent relaxations in aortic rings precontracted with methoxamine. This effect was significantly reduced by removal of the endothelium, and after pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME, 300 μM), indomethacin (10 μM) and 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ, 10 μM), but not 9-(tetrahydro-2-furanyl)-9H-purine-6-amine (SQ22536, 100 μM). Relaxant responses to DMF were significantly inhibited by high KCl (60 mM) in both endothelium-intact and -denuded rings. In addition, the relaxations to DMF were significantly reduced by pretreatment with tetraethylammonium (TEA, 5 mM), glibenclamide (10 μM), 4-aminopyridine (1 mM) or barium chloride (10 μM). Preincubation with DMF (10 and 100 μM) for 30 min significantly inhibited the contractile responses to CaCl(2) in a Ca(2+)-free, high K(+) buffer. The present study demonstrated that DMF causes endothelium-dependent relaxation that is partly mediated by NO-cGMP and cyclooxygenase pathways. Interestingly, DMF-induced responses are mainly due to increasing K(+) efflux, and inhibition of Ca(2+) influx from the extracellular space. The vasodilator effects of DMF provide experimental support for the potential use of KP as a medical plant in the treatment of cardiovascular diseases. Copyright © 2010 John Wiley & Sons, Ltd.

  19. Low stress drops observed for aftershocks of the 2011 Mw 5.7 Prague, Oklahoma, earthquake

    Science.gov (United States)

    Sumy, Danielle F.; Neighbors, Corrie J.; Cochran, Elizabeth S.; Keranen, Katie M.

    2017-05-01

    In November 2011, three Mw ≥ 4.8 earthquakes and thousands of aftershocks occurred along the structurally complex Wilzetta fault system near Prague, Oklahoma. Previous studies suggest that wastewater injection induced a Mw 4.8 foreshock, which subsequently triggered a Mw 5.7 mainshock. We examine source properties of aftershocks with a standard Brune-type spectral model and jointly solve for seismic moment (M0), corner frequency (f0), and kappa (κ) with an iterative Gauss-Newton global downhill optimization method. We examine 934 earthquakes with initial moment magnitudes (Mw) between 0.33 and 4.99 based on the pseudospectral acceleration and recover reasonable M0, f0, and κ for 87 earthquakes with Mw 1.83-3.51 determined by spectral fit. We use M0 and f0 to estimate the Brune-type stress drop, assuming a circular fault and shear-wave velocity at the hypocentral depth of the event. Our observations suggest that stress drops range between 0.005 and 4.8 MPa with a median of 0.2 MPa (0.03-26.4 MPa with a median of 1.1 MPa for Madariaga-type), which is significantly lower than typical eastern United States intraplate events (>10 MPa). We find that stress drops correlate weakly with hypocentral depth and magnitude. Additionally, we find the stress drops increase with time after the mainshock, although temporal variation in stress drop is difficult to separate from spatial heterogeneity and changing event locations. The overall low median stress drop suggests that the fault segments may have been primed to fail as a result of high pore fluid pressures, likely related to nearby wastewater injection.

  20. THE FAINT-END SLOPE OF THE REDSHIFT 5.7 Ly{alpha} LUMINOSITY FUNCTION

    Energy Technology Data Exchange (ETDEWEB)

    Henry, Alaina L.; Martin, Crystal L. [Department of Physics, University of California, Santa Barbara, CA 93106 (United States); Dressler, Alan; McCarthy, Patrick [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Sawicki, Marcin, E-mail: ahenry@physics.ucsb.edu [Department of Astronomy and Physics, Saint Mary' s University, Halifax, NS B3H 3C3 (Canada)

    2012-01-10

    Using new Keck DEIMOS spectroscopy, we examine the origin of the steep number counts of ultra-faint emission-line galaxies recently reported by Dressler et al. We confirm six Ly{alpha} emitters (LAEs), three of which have significant asymmetric line profiles with prominent wings extending 300-400 km s{sup -1} redward of the peak emission. With these six LAEs, we revise our previous estimate of the number of faint LAEs in the Dressler et al. survey. Combining these data with the density of bright LAEs in the Cosmic Evolution Survey and Subaru Deep Field provides the best constraints to date on the redshift 5.7 LAE luminosity function (LF). Schechter function parameters, {phi}* = 4.5 Multiplication-Sign 10{sup -4} Mpc{sup -3}, L* = 9.1 Multiplication-Sign 10{sup 42} erg s{sup -1}, and {alpha} = -1.70, are estimated using a maximum likelihood technique with a model for slit-losses. To place this result in the context of the UV-selected galaxy population, we investigate how various parameterizations of the Ly{alpha} equivalent width distribution, along with the measured UV-continuum LF, affect shape and normalization of the Ly{alpha} LF. The nominal model, which uses z {approx} 6 equivalent widths from the literature, falls short of the observed space density of LAEs at the bright end, possibly indicating a need for higher equivalent widths. This parameterization of the equivalent width distribution implies that as many as 50% of our faintest LAEs should have M{sub UV} > -18.0, rendering them undetectable in even the deepest Hubble Space Telescope surveys at this redshift. Hence, ultra-deep emission-line surveys find some of the faintest galaxies ever observed at the end of the reionization epoch. Such faint galaxies likely enrich the intergalactic medium with metals and maintain its ionized state in the post-reionization era. Observations of these objects provide a glimpse of the building blocks of present-day galaxies at an early time.

  1. Odd [n]Cumulenes (n = 3, 5, 7, 9): Synthesis, Characterization, and Reactivity.

    Science.gov (United States)

    Wendinger, Dominik; Tykwinski, Rik R

    2017-06-20

    In comparison to the omnipresent two- and three-dimensional allotropes of carbon, namely, graphite and diamond (as well as recent entries graphene, carbon nanotubes, and fullerenes), a detailed understanding of the one-dimensional carbon allotrope carbyne is not well established, and even the existence of carbyne has been a matter of controversy over the past decades. Composed of sp-hybridized carbon, carbyne could potentially exist in two forms, either as a polyyne (alternating single and triple bonds, expected to show a semiconducting behavior) or as a cumulene (all carbon atoms are connected via double bonds, predicted to show metallic behavior). Although a number of publications are available on the hypothetical structure and properties of carbyne, specific knowledge about its physical and spectroscopic characteristics is still unclear. In order to predict the properties of carbyne, the synthesis and study of model compounds, namely, polyynes and cumulenes, has been a promising avenue. The synthesis of polyynes has been extensively explored in the last decades, culminating with the isolation of a polyyne with 22 acetylene units, which allows extrapolation to the properties of carbyne. Extended cumulenes, on the other hand, have remained much less well-known, and specific studies of properties versus molecular length are quite limited. A limiting factor to the study of [n]cumulenes has been their dramatically increased reactivity, especially in comparison to polyynes of comparable length. For example, most known [7]cumulenes can only be handled in solution, while the polyynes of equivalent length (i.e., a triyne with three acetylene units) are quite stable. [9]Cumulenes are the longest derivatives studied to date. In this Account, we describe our efforts to design and synthesize odd [n]cumulenes (i.e., n = 3, 5, 7, 9) that are sufficiently persistent under ambient conditions to allow in depth characterization of physical and spectral properties. This goal has

  2. Tooth wear in the deciduous dentition of 5-7-year-old children: risk factors.

    Science.gov (United States)

    Gatou, Tarsitsa; Mamai-Homata, Eleni

    2012-06-01

    This study was conducted to investigate the distribution and severity of tooth wear in deciduous dentition and its relationship with possible risk factors. A stratified cluster sample of 243 5-7-year-old children was examined using the tooth wear index of Smith and Knight, and their exposure to intrinsic and extrinsic risk factors was retrospectively investigated through a structured questionnaire. The severity of wear was quantitatively estimated by the number of surfaces with affected dentine and by the cumulative score of the sextants, based on the Basic Erosive Wear Examination scoring system. Only 1.6% of the children were tooth wear free, whereas 45.6% had moderate to severe wear involving dentine. Maxillary canines were the most affected teeth (83.2%), and occlusal/incisal the most affected surfaces (52.7%). The likelihood of tooth wear involving dentine was greater in boys than girls (OR = 1.72), in immigrants than in Greeks (OR = 1.93), and in 6- and 7-year olds than in 5-year olds (OR = 2.78 to 2.93). After adjustment for age, gender, and nationality, exposure to several dietary factors and especially to soft drinks was found to significantly affect the prevalence (OR = 1.27) and the severity of tooth wear. Every additional serving/week of consumption of soft drinks increases the number of surfaces with dentine affected by 0.03 per year (p children with the higher prevalence and severity of tooth wear had an average exposure to soft drinks of 10 servings/week for a duration of 4 years. The cumulative score of sextants was better predicted by the assessed risk factors, in comparison with the number of surfaces with affected dentine. Tooth wear is a common condition in children, related both to the physiological process of aging of dentition and to the erosive effect of dietary factors. Strategies to reduce the intake of soft drinks in children are expected to have multiple benefits preventing tooth wear in childhood and in later life, as well as many other

  3. Decline of hepatitis B antibody level in vaccinated 5-7 year-old children

    Directory of Open Access Journals (Sweden)

    Mitra Safari

    2010-06-01

    Full Text Available Background: Vaccination is the best way to prevent hepatitis B infection. The efficacy of hepatitis B vaccine and duration of protection after vaccination in infants is unknown. The aim of this study was to evaluate the immunity level of school age children against HBV in order to determine the decline of hepatitis B antibody level during the childhood period.Materials and Methods: This cross-sectional research was performed on 729, 5-7 year-old children in Kohgiloyeh& Boyerahmad Province who had been vaccinated at birth. Patients selected by multiple stage sampling method. While interviewing parents the questionnaire were completed. The laboratory rep[ort was attached to the questionnaire. After confirming the correct date of vaccination time, parents were asked for an informed consent. From each patient 3ml blood sample were taken and hepatitis B surface antibody (HBs-Ab and hepatitis B surface antigen (HBs-Ag were determined by ELISA method. Chi-squared and t-tests were used to analyze obtained data by using SPSS-15 software.Results: HBs-Ag was negative in all patients. 84.4% of subjects were immune against HBV (had protective antibody titer. The mean antibody titer was 308.9±230.5 IU/ml with range of 10.6–1175 IU/ml. 15.6% of samples had non protective antibody titer and mean antibody titer was 4.97 ±3. 5 IU/ml. Anti-HBsAb titers were related to the age and residency of children. The immunity level decreased with increasing age. No statistically significant differences could be found between two sexes. Conclusion: Based on this stud, the immunity persistency rate in this age group was suitable compared to other studies. Unfortunately, there is about 20% of non-immune children to HBV infection in this susceptible age with a high risk of contamination and affliction. Because of seriousness of HBV infection proper immunization strategy should be considered in this era by health care authorities

  4. Damage and Shaking Intensity in the M5.7 Canyondam Earthquake

    Science.gov (United States)

    Boatwright, J.; Chapman, K.; Gold, M. B.; Hardebeck, J. L.

    2013-12-01

    An M5.7 earthquake occurred southeast of Lake Almanor, CA, at 8:47 PM on May 23, 2013. Double-difference relocations of the main shock and aftershocks indicate that the earthquake nucleated at 11 km depth and ruptured up dip on a fault striking 292° and dipping 70° to the northeast. The earthquake cracked foundations, broke chimneys, and ruptured plumbing around Lake Almanor. We canvassed communities around the lake and to the south and east for earthquake damage, adding reports from our interviews to the geocoded 'Did You Feel It?' reports and to a set of damage reports collected by the Plumas County Office of Emergency Services. Three communities suffered significant damage. In Lake Almanor West, 14 km and 290° from the hypocenter, one wood-frame house was shifted on its foundation, the cripple wall of another house was racked, and water and gas pipes in five houses were ruptured. This damage indicates the shaking approached MMI 8. In Lake Almanor Country Club, 10 km and 310° from the hypocenter, more than 40 chimneys were cracked, broken, or collapsed, a coupling for the municipal water tank was ruptured, and a 200-foot long fissure opened on a slope facing the lake. This damage indicates shaking between MMI 7 and MMI 8, consistent with the accelerograph recording of PGA = 38% g and PGV = 30 cm/s at the Fire Station in Lake Almanor Country Club. This CSMIP station and a PG&E station on the crest of the Butt Valley Dam obtained the only recordings within 50 km of the epicenter. In Hamilton Branch, 10 km and 345° from the hypocenter, a foundation of a wood-frame house was damaged, and 14 chimneys and a water pipe were broken, indicative of MMI 7 shaking. All three communities are underlain by Tertiary and Quaternary basalts. The communities of Chester, Westwood, and Greenville were less damaged, suffering cracked drywall, broken windows, and objects thrown from shelves. The intensities in the three most strongly damaged communities increase as the azimuth

  5. Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma.

    Science.gov (United States)

    Akizuki, Risa; Shimobaba, Shun; Matsunaga, Toshiyuki; Endo, Satoshi; Ikari, Akira

    2017-02-01

    Abnormal expression of claudin (CLDN) subtypes has been reported in various solid cancers. However, it is unknown which subtype plays a key role in the regulation of proliferation in cancer cells. The expression of CLDN3-5, 7, and 18 in human lung squamous carcinoma tissues was lower than that in normal tissue. Here, we examined which combination of exogenous CLDNs expression inhibits proliferation and the molecular mechanism using human lung squamous RERF-LC-AI cells. Real-time polymerase chain reaction and western blotting showed that CLDN3-5, 7, and 18 are little expressed in RERF-LC-AI cells. In the exogenously transfected cells, CLDN5, 7, and 18 were distributed in the cell-cell contact areas concomitant with ZO-1, a tight junctional scaffolding protein, whereas CLDN3 and 4 were not. Cell proliferation was individually and additively suppressed by CLDN5, 7, and 18. The expression of these CLDNs showed no cytotoxicity compared with mock cells. CLDN5, 7, and 18 increased p21 and decreased cyclin D1, resulting in the suppression of cell cycle G1-S transition. The expression of these CLDNs inhibited phosphorylation of Akt without affecting phosphorylated ERK1/2. Furthermore, these CLDNs inhibited the nuclear localization of Akt and its association with 3-phosphoinositide-dependent protein kinase-1 (PDK1). The suppression of G1-S transition caused by CLDN5, 7, and 18 was rescued by the expression of constitutively active-Akt. We suggest that the reduction of CLDN5, 7, and 18 expression loses the suppressive ability of interaction between PDK1 and Akt and causes sustained phosphorylation of Akt, resulting in the disordered proliferation in lung squamous carcinoma cells.

  6. A fast degrading odd-odd aliphatic polyester-5,7 made by condensation polymerization for biomedical applications.

    Science.gov (United States)

    Chen, Fei; Nölle, Jan Martin; Wietzke, Steffen; Reuter, Marco; Chatterjee, Sangam; Koch, Martin; Agarwal, Seema

    2012-01-01

    A fast enzymatic degradable aliphatic all-odd-polyester-5,7, based on 1,7-heptanedioic acid (pimelic acid) and 1,5-pentanediol, was synthesized by polycondensation. The structural characterization of the polyester was done using 1D- and 2D-NMR spectroscopic techniques. The properties of the resulting polyester-like crystallization behavior, enzymatic degradation, thermal stability, etc., were investigated using differential scanning calorimetry, wide-angle X-ray diffraction, scanning electron microscopy and gel-permeation chromatography. Terahertz time-domain spectroscopy was employed to determine the glass transition temperature, which could not be revealed reliably by conventional thermal analysis. The properties of all-odd-polyester-5,7 were compared with a well-known enzymatic degradable polyester (polycaprolactone). The results indicated that polyester-5,7 has a crystal structure similar to PCL, but a much faster degradation rate. The morphology of polyester-5,7 film during enzymatic degradation showed a fibrillar structure and degradation began by surface erosion.

  7. [Papers Presented at the American Medical Association's Air Pollution Medical Research Conference (New Orleans, Louisiana, October 5-7, 1970).

    Science.gov (United States)

    American Medical Association, Chicago, IL.

    This is a collection of twenty speeches presented at the American Medical Association's Air Pollution Medical Conference, October 5-7, 1970. Speeches included: Air Pollution Control: The Physician's Role; Air Pollution Problems in Nuclear Power Development; Airway Resistance and Collateral Ventilation; Asbestos Air Pollution in Urban Areas;…

  8. 5/7单基药灌注炸药的制备及性能研究❋%Research on Preparation and Properties of Perfusion Explosive Containing 5/7 Single Base Propellant

    Institute of Scientific and Technical Information of China (English)

    张迪; 魏晓安; 俞永华; 王泽山

    2016-01-01

    [ ABSTRACT] Water-resistance perfusion explosives containing 5/7 single base propellant were manufactured by three kinds of fillers ( R1 , R2 and R3 ) . Filling problems in small pores was resolved by the improved technology. In underwater explosion, the TNT equivalent of perfusion explosive with R1 , R2 and R3 were 0. 97, 1. 11 and 1. 34 respectively, and energies of perfusion explosives obviously increase. Furthermore, energies of perfusion explosives were especially related with the characters of R1 , R2 and R3 . Detonations of perfusion explosives with the fillers of white, R2 and R3 were tested through high speed photography. Results show that fire balls are also different among high energy and low energy fillers, and the brilliance and shape of fire ball from R3 is more than those from R2 . Meanwhile, the perfusion explosive with the filler of white still shows inflammation. This result is also according with the effect from the underwater explosions.%针对5/7单基药,采用了R1、R2和R33种不同的填充材料制备抗水型灌注炸药。利用改进的工艺解决了5/7单基药小孔隙的填充问题;该炸药的水下测试结果显示,含R1、R2和R3的灌注炸药TNT当量为0.97、1.11和1.34,能量呈明显递增关系,结果与灌注液和发射药颗粒能量匹配相对应;对R2和R3灌注炸药以及5/7单基药颗粒的爆炸过程进行高速摄影,发现它们在相同时间段火球明显不同,R3灌注炸药火球亮度、大小及持续时间明显超过R2体系,这与水下爆炸结果相一致,而未灌注的5/7单基药颗粒在冲击作用下还存在燃烧现象。这些结果为配方设计提供了依据。

  9. Chronic proliferative rhinitis associated with Salmonella enterica subspecies diarizonae serovar 61:k:1, 5, (7) in sheep in Spain.

    Science.gov (United States)

    Lacasta, D; Ferrer, L M; Ramos, J J; Bueso, J P; Borobia, M; Ruiz de Arcaute, M; Figueras, L; González-Sainz, J M; De Las Heras, M

    2012-11-01

    A chronic proliferative rhinitis in sheep associated with Salmonella enterica subspecies diarizonae serovar 61:k:1, 5, (7) is described. Ten adult sheep from eight traditionally managed Rasa Aragonesa flocks located in Aragon (Spain) were studied. Clinical signs began with bilateral thick mucus nasal discharge, wheezing and snoring and progressed to partial or complete obstruction of the nostrils. Necropsy examination revealed swollen ventral nasal turbinates with a roughened mucosal surface partially covered by small polyps. Histopathology revealed chronic proliferative rhinitis with a predominant population of neutrophils that infiltrated the mucosal epithelium. Plasma cells and macrophages were present in the lamina propria. Organisms expressing Salmonella antigen immunohistochemically were detected within epithelial cells. Salmonella enterica subspecies diarizonae serovar 61:k:1, 5, (7) was isolated as a sole microorganism from nasal swabs taken from five animals. The implication of finding this bacterium in various diseases in sheep and its role as a potential zoonosis are discussed.

  10. EFFECTS OF 5, 7-DIHYDROXYTRYPTAMINE-INDUCED DEPLETION OF BRAIN SEROTONIN ON RADIAL ARM-MAZE TASK IN RATS

    Directory of Open Access Journals (Sweden)

    Vasile Hefco

    2005-08-01

    Full Text Available Adult rats pretreated with desipramine (25 mg/kg i.p.30 min before anesthesia in order to protect noradrenergic system, were subjected to intracerebroventriculare injection of 5, 7 –dihydroxytryptamine (5, 7-DHT, 150 μg, 4.5 μl/ventricle, a chronic neurotoxin of the central serotonergic function. After 1.5 months later, we assessed the working memory and reference memory in radial 8 arm-mazes. Serotonergic depletion impaired more significantly shortterm memory tested by means of the average working memory errors, entries to repeat and average time taken to consume all five baits during 12 days training. Long-term memory, explored by means of reference memory errors, was less impaired. It is concluded that serotonin, among other neurotransmitters, play one important role in cognitive functions, including learning and memory.

  11. Teaching computer science to 5-7 year-olds:an initial study with Scratch, Cubelets and unplugged computing

    OpenAIRE

    Wohl, Benjamin; Porter, Barry; Clinch, Sarah

    2015-01-01

    Changes to school curriculums increasingly require the introduction of computer science concepts to younger children. This practical report compares three existing tools for teaching computer science concepts: unplugged computing, tangible computing and MIT's Scratch. We specifically focus on the use of these tools for school pupils aged 5--7. We describe a comparative study with 28 pupils from three rural UK primary schools that explores engagement with, and effectiveness of, each tool. As f...

  12. Amino and nitro derivatives of 5,7-dimethoxyflavone from Kaempferia parviflora and cytotoxicity against KB cell line.

    Science.gov (United States)

    Wanich, Suchana; Yenjai, Chavi

    2009-09-01

    Structural modification of 5,7-dimethoxyflavone isolated from Kaempferia parviflora furnished two nitro and seven amino derivatives. Among these, six new (3, 5-6, 8-10) and three known (2, 4, 7) flavonoid derivatives were synthesized. All compounds were evaluated for cytotoxicity against KB cell line using colorimetric method. Compounds 6 and 8 exhibited strong cytotoxicity with IC50 values of 6.80 and 5.84 microg/mL, respectively.

  13. HST/ACS Morphology of Lyman Alpha Emitters at Redshift 5.7 in the COSMOS Field

    CERN Document Server

    Taniguchi, Y; Scoville, N Z; Sasaki, S S; Nagao, T; Shioya, Y; Saitô, T; Ideue, Y; Nakajima, A; Matsuoka, K; Sanders, D B; Mobasher, B; Aussel, H; Capak, P; Salvato, M; Koekemoer, A; Carilli, C; Cimatti, A; Ellis, Richard S; Garilli, B; Giavalisco, M; Ilbert, O; Impey, C D; Kitzbichler, M G; Le Fèvre, O; McCracken, H J; Scarlata, C; Schinnerer, E; Smolcic, V; Tribiano, S; Trump, J R

    2009-01-01

    We present detailed morphological properties of Lyman alpha emitters (LAEs) at z~ 5.7 in the COSMOS field, based on {\\it Hubble Space Telescope} Advanced Camera for Surveys (ACS) data. The ACS imaging in the F814W filter covered 85 LAEs of the 119 LAEs identified in the full two square degree field, and 47 LAEs of them are detected in the ACS images. Nearly half of them are spatially extended with a size larger than 0.15 arcsec (~0.88 kpc at z=5.7) up to 0.4 arcsec (~2.5 kpc at z=5.7). The others are nearly unresolved compact objects. Two LAEs show double-component structures, indicating interaction or merging of building components to form more massive galaxies. By stacking the ACS images of all the detected sources, we obtain a Sersic parameter of n~0.7 with a half-light radius of 0.13 arcsec (0.76 kpc), suggesting that the majority of ACS detected LAEs have not spheroidal-like but disk-like or irregular light profiles. Comparing ACS F814W magnitudes (I_814) with Subaru/Suprime-Cam magnitudes in the NB816, ...

  14. 一种有效合成5,7-二甲氧基-1-茚酮的方法%An Effect Synthesis Method of 5,7-Dimethoxy-1-Indanone

    Institute of Scientific and Technical Information of China (English)

    周德军; 松谷裕二

    2013-01-01

    An effective novel method for synthesis of 5, 7-dimethoxy-l-indanone using diethyl 2-( 3, 5-dimethoxybenzyl)malonate, which is readily prepared, as starting material was successfully developed. A mixture of starting material in methanesulfonic acid at 100℃ was stirred for 2 h the product can be afforded in 95% yield. Because of only needing cheaper starting material, easier workup and normal equipments, this reaction could be applied to industrial production. Furthermore, the possible mechanism of the reaction was proposed.%成功开发一种由容易得到的2-(3,5-二甲氧基苄基)丙二酸二乙酯为原料合成5,7-二甲氧基1-茚酮的有效新方法.将原料溶解于甲磺酸中,加热到100℃反应2h收率可以达到95%.本反应所需原料廉价、后处理简单、对设备要求不高,适用于工业化生产.另外,文中还提出了该反应可能的反应机理.

  15. 花生壳中5,7-二羟基色原酮及圣草酚的HPLC测定%HPLC determination of 5,7-dihydroxychromone and eriodictyol of peanut hulls

    Institute of Scientific and Technical Information of China (English)

    姚利; 林玉萍; 龚云麒; 饶高雄; 孙汉董

    2006-01-01

    建立了测定花生壳中5,7-二羟基色原酮和圣草酚的HPLC方法.色谱选用Kromasil C18柱(4.6mm×150mm×5μm),以甲醇:1%磷酸(48:52,v/v)为流动相,流速1.0mL/min,检测波长254nm.5,7-二羟基色原酮和圣草酚标准曲线的线性范围分别为0.064~0.48μg和0.080~0.60μg,相关系数分别为0.9999和0.9999.此方法样品前处理简单、方便,测定结果准确、重现,可用于花生壳及其提取产品的质量分析与控制.

  16. Evaluation of a multiplex PCR to identify and serotype Actinobacillus pleuropneumoniae serovars 1, 5, 7, 12 and 15.

    Science.gov (United States)

    Turni, C; Singh, R; Schembri, M A; Blackall, P J

    2014-10-01

    The aim of this study was to validate a multiplex PCR for the species identification and serotyping of Actinobacillus pleuropneumoniae serovars 1, 5, 7, 12 and 15. All 15 reference strains and 411 field isolates (394 from Australia, 11 from Indonesia, five from Mexico and one from New Zealand) of A. pleuropneumoniae were tested with the multiplex PCR. The specificity of this multiplex PCR was validated on 26 non-A. pleuropneumoniae species. The multiplex PCR gave the expected results with all 15 serovar reference strains and agreed with conventional serotyping for all field isolates from serovars 1 (n = 46), 5 (n = 81), 7 (n = 80), 12 (n = 16) and serovar 15 (n = 117). In addition, a species-specific product was amplified in the multiplex PCR with all 411 A. pleuropneumoniae field isolates. Of 25 nontypeable field isolates only two did not yield a serovar-specific band in the multiplex PCR. This multiplex PCR for serovars 1, 5, 7, 12 and 15 is species specific and capable of serotyping isolates from diverse locations. Significance and impact of the study: A multiplex PCR that can recognize serovars 1, 5, 7, 12 and 15 of A. pleuropneumoniae was developed and validated. This novel diagnostic tool will enable frontline laboratories to provide key information (the serovar) to guide targeted prevention and control programmes for porcine pleuropneumonia, a serious economic disease of pigs. The previous technology, traditional serotyping, is typically provided by specialized reference laboratories, limiting the capacity to respond to this key disease. © 2014 The Society for Applied Microbiology.

  17. Confirmation of a Steep Luminosity Function for Ly alpha Emitters at z 5.7: a Major Component of Reionization

    Science.gov (United States)

    Dressler, Alan; Henry, Alaina L.; Martin, Crystal L.; Sawicki, Marcin; McCarthy, Patrick; Villaneuva, Edward

    2014-01-01

    We report the first direct and robust measurement of the faint-end slope of the Ly-alpha emitter (LAE) luminosity function at z = 5.7. Candidate LAEs from a low-spectral-resolution blind search with IMACS on Magellan- Baade were targeted at higher resolution to distinguish high redshift LAEs from foreground galaxies. All but 2 of our 42 single-emission-line systems are fainter than F = 2.0×10(exp-17) ergs s(exp-1) cm(exp-2), making these the faintest emission-lines observed for a z = 5.7 sample with known completeness, an essential property for determining the faint end slope of the LAE luminosity function. We find 13 LAEs as compared to 29 foreground galaxies, in very good agreement with the modeled foreground counts predicted in Dressler et al. (2011a) that had been used to estimate a faint-end slope of alpha = -2.0 for the LAE luminosity function. A 32% LAE fraction, LAE/(LAE+foreground) within the flux interval F = 2-20 × 10(exp-18) ergs s(exp-1) cm(exp-2) constrains the faint end slope of the luminosity function to -1.95 greater than alpha greater than -2.35 (1 delta). We show how this steep LF should provide, to the limit of our observations, more than 20% of the flux necessary to maintain ionization at z = 5.7, with a factor-of-ten extrapolation in flux reaching more than 55%. We suggest that this bodes well for a comparable contribution by similar, low-mass star forming galaxies at higher-redshift - within the reionization epoch at z greater than approximately 7, only 250 Myr earlier - and that such systems provide a substantial, if not dominant, contribution to the late-stage reionization of the IGM.

  18. Observations of static Coulomb stress triggering of the November 2011 M5.7 Oklahoma earthquake sequence

    Science.gov (United States)

    Sumy, Danielle F.; Cochran, Elizabeth S.; Keranen, Katie M.; Wei, Maya; Abers, Geoffrey A.

    2014-01-01

    In November 2011, a M5.0 earthquake occurred less than a day before a M5.7 earthquake near Prague, Oklahoma, which may have promoted failure of the mainshock and thousands of aftershocks along the Wilzetta fault, including a M5.0 aftershock. The M5.0 foreshock occurred in close proximity to active fluid injection wells; fluid injection can cause a buildup of pore fluid pressure, decrease the fault strength, and may induce earthquakes. Keranen et al. [2013] links the M5.0 foreshock with fluid injection, but the relationship between the foreshock and successive events has not been investigated. Here we examine the role of coseismic Coulomb stress transfer on earthquakes that follow the M5.0 foreshock, including the M5.7 mainshock. We resolve the static Coulomb stress change onto the focal mechanism nodal plane that is most consistent with the rupture geometry of the three M ≥ 5.0 earthquakes, as well as specified receiver fault planes that reflect the regional stress orientation. We find that Coulomb stress is increased, e.g., fault failure is promoted, on the nodal planes of ~60% of the events that have focal mechanism solutions, and more specifically, that the M5.0 foreshock promoted failure on the rupture plane of the M5.7 mainshock. We test our results over a range of effective coefficient of friction values. Hence, we argue that the M5.0 foreshock, induced by fluid injection, potentially triggered a cascading failure of earthquakes along the complex Wilzetta fault system.

  19. Observation and analysis of geomagnetic abnormity associated with the Ms=5.7 Jiujiang-Ruichang earthquake

    Institute of Scientific and Technical Information of China (English)

    GU Zuo-wen; ZHANG Yi; YAO Tong-qi; GAO Jin-tian; LIU Xin; CHEN Bin; ZHAN Zhi-jia; GU Chun-lei

    2006-01-01

    A three-component geomagnetic survey was carried out during the period from 2002 to 2004 in China including Jiujiang-Ruichang region. Comparing the "2005.0 surface spline model of China geomagnetic field" created on the basis of the survey data with the "1970.0 surface spline model of China geomagnetic field", we can see an obvious abnormity in the geomagnetic horizontal component within a range of about 100 km around the epicenter of the Ms=5.7 Jiujiang-Ruichang earthquake occurred on November 26, 2005. After the earthquake, we carried out a repeated geomagnetic survey at 21 stations in the Jiujiang-Ruichang region and created a corresponding "2005.0 partially revised surface spline model of China geomagnetic field". By comparing the above three models, analyzing the geomagnetic horizontal component at the profile in the Jiujiang-Ruichang region and quantitatively studying the geomagnetic data of every stations around the Ms=5.7 earthquake, we have obtained the geomagnetic abnormity associated with this earthquake. Then the geomagnetic abnormity and its relation with seismic activity are discussed in this paper.

  20. Mapeamento de locos de características quantitativas nos cromossomos 5, 7 e 8 de suínos Mapping of quantitative trait loci mapping in chromosomes 5, 7 and 8 of swines

    Directory of Open Access Journals (Sweden)

    Katiene Régia Silva Sousa

    2011-01-01

    Full Text Available Objetivou-se mapear QTL nos cromossomos 5, 7 e 8 e associá-los a características de carcaça, cortes de carcaça, qualidade de carne, desempenho e órgãos internos de suínos. Uma progênie F2 de 614 animais foi produzida do cruzamento de dois varrões da raça naturalizada brasileira Piau e 18 fêmeas comerciais (Landrace x Large White x Pietrain. A população foi genotipada para 14 marcadores microssatélites cobrindo os cromossomos 5, 7 e 8. Em seguida, foi construído o mapa de ligação para cada cromossomo. As análises de associação foram feitas usando o mapeamento de intervalo por regressão para detecção de QTL. Para características de carcaça e cortes de carcaça, foram mapeados 20 QTL nos três cromossomos, enquanto, para características de qualidade de carne, foram encontrados apenas três QTL nos cromossomos 7 e 8. Entre eles, QTL significativos a 5% no genoma foram encontrados para menor espessura de toucinho na região acima da última vértebra lombar, na linha dorsolombar no cromossomo 5; e para comprimento total do intestino delgado, peso da banha-rama e luminosidade no cromossomo 8. Para comprimento de carcaça pelo método brasileiro e comprimento de carcaça pelo método americano, QTL significativos a 1% no genoma foram encontrados no cromossomo 7. Os resultados encontrados facilitarão estudos futuros, como o mapeamento fino e a identificação de genes que controlam a composição corporal e a qualidade de carne e que poderão ser incorporados em programas de seleção assistida por marcadores para acelerar o melhoramento genético de populações de suínos, além de ajudar no melhor entendimento da fisiologia das características de produção de suínos.The aim of this experiment was to map QTL in chromosomes 5, 7 and 8 and to associate them to carcass traits, carcass cuts, meat quality, performance and internal organs of swines. An F2 offspring with 614 animals was produced from the matting of two Brazilian

  1. Quantitative analysis of damage in an octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazonic-based composite explosive subjected to a linear thermal gradient

    Science.gov (United States)

    Peterson, Paul D.; Mang, Joseph T.; Asay, Blaine W.

    2005-05-01

    The microstructure within a slowly heated, consolidated explosive will be influenced by both physical changes and chemical reactions prior to thermal ignition. Thermal expansion, exothermic decomposition, endothermic phase change, and increased binder viscosity play significant roles in the cook-off to detonation. To further explore the details of this intricate cook-off process, we have conducted a series of experiments in which a carefully controlled temperature gradient has been applied along a cylinder of PBX 9501 [94.9/2.5/2.5/0.1-wt % octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)/Estane 5703/a eutectic mixture of bis(2,2 dinitropropyl) acetal and bis(2,2-dinitropropyl) formal [abbreviated BDNPA-F]/Irganox] and maintained for a specified amount of time. After heating and subsequent cooling of the PBX 9501, the sample morphology has been probed with polarized light microscopy and small-angle x-ray scattering. Using these techniques we have quantitatively characterized the particle morphology, porosity, and chemical state of the explosive as a function of position, and therefore thermal treatment. Results of the analyses clearly show that thermal damage in PBX 9501 can be classified into two separate temperature regimes—an initial low-temperature regime (155-174°C) dominated by the endothermic β-δ crystalline phase change, thermal expansion, and Ostwald ripening, and a high-temperature regime (175-210°C) dominated by exothermic chemical decomposition. The results further show the complex interplay between the evolving sample morphology and the chemical reactions leading to a potential thermal self-ignition in the explosive.

  2. 3,5,7,3',4'-pentamethoxyflavone, a quercetin derivative protects DNA from oxidative challenges: potential mechanism of action.

    Science.gov (United States)

    Jakhar, Rekha; Paul, Souren; Park, Young Rong; Han, Jaehong; Kang, Sun Chul

    2014-02-01

    DNA protection is one of the most important strategies in cancer therapy. Since quercetin and its derivatives are found to be potent antioxidant agents, they are able to scavenge radicals significantly. Therefore, we focused on the DNA protection activity of 3,5,7,3',4'-pentamethoxyflavone (PMF), a quercetin derivative isolated from Kaemperia parviflora. Although, PMF was found to be a very poor antioxidant compound, still it could remarkably protect DNA from oxidative damage. DNA binding assay showed that PMF bound to the minor groove of DNA, which suggests a possible mechanism for its DNA protective effects. Cellular toxicity assay on RAW 264.7 macrophages showed this compound is very safe for therapeutic applications.

  3. Influence of structure 3,5,7,3‧,4‧-Pentahydroxyflavone-based polymer films on their optical transparency

    Science.gov (United States)

    Mishurov, Dmytro; Voronkin, Andrii; Roshal, Alexander; Bogatyrenko, Sergey

    2017-02-01

    Optical properties and morphology of polymer films based on diglycidyl ether of bis-phenol A and on natural compound 3,5,7,3‧,4‧-pentahydroxyflavone (quercetin) using UV-vis spectroscopy, scanning electron microscopy and powder X-ray diffraction methods have been investigated. The influence of ordering degree of the polymers, flexibility of their chains, intensity of intermolecular interaction between the quercetine moieties on the polymers' morphology was discussed. It is shown that all the quercetine-based polymer films are transparent at visible and near infrared regions beginning from 420 to 450 nm. Low optical transparency in the short-wavelength region can be explained the self-absorption of quercetin moieties in the polymer chains.

  4. Genetic and Environmental Influences on Literacy and Numeracy Performance in Australian School Children in Grades 3, 5, 7, and 9.

    Science.gov (United States)

    Grasby, Katrina L; Coventry, William L; Byrne, Brian; Olson, Richard K; Medland, Sarah E

    2016-09-01

    We examined the extent to which genes and the environment contributed to variation in and covariation among reading, spelling, grammar and punctuation, writing, and numeracy in Australian school children in Grades 3, 5, 7, and 9. Heritability was generally high: reading .58-.71 (excepting Grade 5 girls), spelling .68-.78; grammar and punctuation .52-.66, writing .39-.52, and numeracy .39-.79. Boys' performance varied more than girls in spelling and numeracy, and the common environment was a greater influence in girls than boys in Grade 3 numeracy and Grade 5 reading. Independent pathway models showed similar genetic and environmental structures at each grade with approximately one third to one half of the variation in each domain due to genes that influenced all domains. The covariation among the domains was largely mediated by genes. Results suggest substantial uniformity in the environmental factors influencing these academic domains.

  5. Functional somatic symptoms and associated impairment in 5-7-year-old children: the Copenhagen Child Cohort 2000

    DEFF Research Database (Denmark)

    Rask, Charlotte Ulrikka; Olsen, Else Marie; Elberling, Hanne;

    2009-01-01

    Research on somatisation or functional disorders, characterised by the subjective report of physical symptoms in the absence of clear physical pathology, in young children is limited. This study investigates the distribution, types and co-occurrence of parent-reported functional somatic symptoms......,327 children. The newly introduced parent interview, the soma assessment interview, was used to assess the child's FSS. Impairing symptoms were defined as FSS that caused substantial discomfort, impairment of everyday life, absence from day-care or school and/or help-seeking in the health care system. The 1...... with two or more of these functional pain complaints, while 15 (4.9%) had all three types. The findings indicate that FSS are common health complaints in 5-7-year-old children. A subgroup with impairing FSS with a likely need of clinical intervention was identified. This suggests that a somatisation...

  6. The association between prenatal psychosocial stress and blood pressure in the child at age 5-7 years.

    Directory of Open Access Journals (Sweden)

    Aimée E van Dijk

    Full Text Available OBJECTIVE: Prenatal maternal stress could have permanent effects on the offspring's tissue structure and function, which may predispose to cardiovascular diseases. We investigated whether maternal psychosocial stress is a prenatal factor affecting the blood pressure (BP of offspring. STUDY DESIGN: In the Amsterdam Born Children and their Development (ABCD study, around gestational week 16, depressive symptoms, state-anxiety, pregnancy-related anxiety, parenting daily hassles and job strain were recorded by questionnaire. A cumulative stress score was also calculated (based on 80(th percentiles. Systolic and diastolic BP and mean arterial pressure (MAP were measured in the offspring at age 5-7 years. Inclusion criteria were: no use of antihypertensive medication during pregnancy; singleton birth; no reported cardiovascular problems in the child (N = 2968 included. RESULTS: After adjustment for confounders, the single stress scales were not associated with systolic and diastolic BP, MAP and hypertension (p>0.05. The presence of 3-4 psychosocial stressors prenatally (4% was associated with 1.5 mmHg higher systolic and diastolic BP (p = 0.046; p = 0.04 and 1.5 mmHg higher MAP in the offspring (p = 0.02 compared to no stressors (46%. The presence of 3-4 stressors did not significantly increase the risk for hypertension (OR 1.8; 95% CI 0.93.4. Associations did not differ between sexes. Bonferroni correction for multiple testing rendered all associations non-significant. CONCLUSIONS: The presence of multiple psychosocial stressors during pregnancy was associated with higher systolic and diastolic BP and MAP in the child at age 5-7. Further investigation of maternal prenatal stress may be valuable for later life cardiovascular health.

  7. Use of a low-prime circuit for bloodless heart transplantation in xenotransplant of 5-7 kilogram primates.

    Science.gov (United States)

    Gomez, D; Olshove, V F; Weinstein, S; Davis, J T; Michler, R E

    2000-09-01

    There is a great effort to decrease blood product use during open-heart surgery in pediatrics. We were presented with a research challenge to accomplish heart xenotransplantation from donor cynomologous monkey (Macaca fascicularis) to recipient olive baboon (Papio anubis) of 5-7 kilograms without benefit of donor or banked blood products. The purpose of this study was to design and implement a practical, low-volume circuit to minimize hemodilution and avoid the use of blood products. A simple circuit was assembled using a low-volume oxygenator with hardshell venous reservoir, an 1/8-inch arterial line, an 1/4-inch venous line, and gravity drainage. Three xenotransplants were performed and evaluated. The mean recipient weights were 6.3 +/- 0.7 kg. Circuit prime volume was 228 +/- 5.8 mL, and bypass time was 85 +/- 6.7 min. Blood flow rates were 585 +/- 113 mL/min with postmembrane arterial line pressures of 344 +/- 81 mmHg, and patient mean arterial pressures (MAP) of 51.4 +/- 16.7 mmHg. Venous saturations were 63.7 +/- 8.0%. The hematocrit prebypass was 37.4 +/- 3.2, bypass 20.7 +/- 0.9, post-MUF 27.8 +/- 3.3, and 7 days postoperative 24.5 +/- 7.5%. Platelet count was 289 +/- 1.1 K/microL, 147 +/- 37.1 K/microL, and 322 +/- 292.7 K/microL prebypass, postbypass, and 7 days postoperative, respectively. Plasma-free hemoglobin prebypass was 7.5 +/- 4.4 mg/dL and postbypass 22.2 +/- 16.5 mg/dL with no noted hematuria during and after the procedure. All patients survived and were successfully weaned from cardiopulmonary bypass (CPB) with same day extubation. A low-prime circuit for bloodless heart surgery is possible. To achieve low reservoir levels, especially without the use of an arterial line filter (ALF), it is necessary to have a full armament of monitoring and alarm devices.

  8. Evaluation of melanogenesis in A-375 melanoma cells treated with 5,7-dimethoxycoumarin and valproic acid.

    Science.gov (United States)

    Chodurek, Ewa; Orchel, Arkadiusz; Orchel, Joanna; Kurkiewicz, Sławomir; Gawlik, Natalia; Dzierżewicz, Zofia; Stępień, Krystyna

    2012-12-01

    Malignant melanoma (melanoma malignum) is one of the most dangerous types of tumor. It is very difficult to cure. In recent years, a lot of attention has been given to chemoprevention. This method uses natural and synthetic compounds to interfere with and inhibit the process of carcinogenesis. In this study, a new treatment strategy was proposed consisting of a combination of 5,7-dimethoxycoumarin (DMC), an activator of melanogenesis, and valproic acid (VPA), a well-known drug that is one of the histone deacetylase inhibitors (HDACis). In conjunction with 1 mM VPA, all of the tested concentrations of DMC (10-150 μM) significantly decreased the proliferation of A-375 cells. VPA and DMC also induced the synthesis of melanin and the formation of dendrite and star-shaped cells. Tyrosinase gene expression and tyrosinase activity significantly increased in response to VPA treatment. Pyrolysis with gas chromatography and mass spectrometry (Py-GC/MS) was used to investigate the structure of the isolated melanin. This showed that the quantitative and qualitative components of melanin degradation products are dependent on the type of applied melanogenesis inductor. Products derived from eumelanin were detected in the pyrolytic profile of melanin isolated from A-375 cells stimulated with DMC. Thermal degradation of melanin isolated from melanoma cells after exposure to VPA or a mixture of VPA and DMC revealed the additional presence of products derived from pheomelanin.

  9. Opposing effects of 5,7-DHT infusions into the orbitofrontal cortex and amygdala on flexible responding.

    Science.gov (United States)

    Man, M S; Dalley, J W; Roberts, A C

    2010-07-01

    Central serotonin is implicated in a variety of emotional and behavioral control processes. Serotonin depletion can lead to exaggerated aversive processing and deficient response inhibition, effects that have been linked to serotonin's actions in the amygdala and orbitofrontal cortex (OFC), respectively. However, a direct comparison of serotonin manipulations within the OFC and amygdala in the same experimental context has not been undertaken. This study compared the effects of infusing the serotonin neurotoxin, 5,7-dihydroxytryptamine into the OFC and amygdala of marmosets performing an appetitive test of response inhibition. Marmosets had to learn to inhibit a prepotent response tendency to choose a box containing high-incentive food and instead choose a box containing low-incentive food, to obtain reward. OFC infusions caused long-lasting reductions in serotonin tissue levels, as revealed at postmortem, and exaggerated prepotent responses. In contrast, the significantly reduced prepotent responses following amygdala infusions occurred at a time when serotonin tissue levels had undergone considerable recovery, but there remained residual reductions in extracellular serotonin, in vivo. These opposing behavioral effects of serotonin manipulations in the same experimental context may be understood in terms of the top-down regulatory control of the amygdala by the OFC.

  10. Mathematics and reading difficulty subtypes: minor phonological influences on mathematics for 5-7-years-old.

    Science.gov (United States)

    Jordan, Julie A; Wylie, Judith; Mulhern, Gerry

    2015-01-01

    Linguistic influences in mathematics have previously been explored through subtyping methodology and by taking advantage of the componential nature of mathematics and variations in language requirements that exist across tasks. The present longitudinal investigation aimed to examine the language requirements of mathematical tasks in young children aged 5-7 years. Initially, 256 children were screened for mathematics and reading difficulties (RDs) using standardized measures. Those scoring at or below the 35th percentile on either dimension were classified as having difficulty. From this screening, 115 children were allocated to each of the mathematical difficulty (MD; n = 26), MDRD (n = 32), RD (n = 22) and typically achieving (n = 35) subtypes. These children were tested at four time points, separated by 6 monthly intervals, on a battery of seven mathematical tasks. Growth curve analysis indicated that, in contrast to previous research on older children, young children with MD and MDRD had very similar patterns of development on all mathematical tasks. Overall, the subtype comparisons suggested that language played only a minor mediating role in most tasks, and this was secondary in importance to non-verbal skills. Correlational evidence suggested that children from the different subtypes could have been using different mixes of verbal and non-verbal strategies to solve the mathematical problems.

  11. A survey of z > 5.7 quasars in the sloan digital sky survey. 4. discovery of seven additional quasars

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Xiao-Hui; Strauss, Michael A.; Richards, Gordon T.; Hennawi, Joseph F.; Becker, Robert H.; White, Richard L.; Diamond-Stanic, Aleksandar M.; onley, Jennifer L.D; Jiang, Lin-Hua; Kim, J.Serena; Vestergaard, Marianne; Young, Jason E.; Gunn, James E.; Lupton, Robert H.; Knapp, Gillian R.; Schneider, Donald P.; Brandt, W.N.; Bahcall, Neta A.; Barentine, J.C.; Brinkmann, J.; Brewington, Howard J.; /Arizona U., Astron. Dept. - Steward Observ. /Princeton U. Observ. /Johns Hopkins U. /UC, Berkeley, Astron. Dept. /UC, Davis

    2005-12-01

    We present the discovery of seven quasars at z > 5.7, selected from {approx}2000 deg{sup 2} of multicolor imaging data of the Sloan Digital Sky Survey (SDSS). The new quasars have redshifts z from 5.79 to 6.13. Five are selected as part of a complete flux-limited sample in the SDSS Northern Galactic Cap; two have larger photometric errors and are not part of the complete sample. One of the new quasars, SDSS J1335+3533 (z = 5.93), exhibits no emission lines; the 3-{sigma} limit on the rest-frame equivalent width of Ly{alpha} + NV line is 5 {angstrom}. It is the highest redshift lineless quasar known, and could be a gravitational lensed galaxy, a BL Lac object or a new type of quasar. Two new z > 6 quasars, SDSS 1250+3130 (z = 6.13) and SDSS J1137+3549 (z = 6.01), show deep Gunn-Peterson absorption gaps in Ly{alpha}. These gaps are narrower the complete Gunn-Peterson absorption troughs observed among quasars at z > 6.2 and do not have complete Ly{beta} absorption.

  12. First half 2006: sales revenue up by 5.7% to euros 5,036 million; 1. semestre 2006: chiffre d'affaires en hausse de 5,7% a 5,036 million d'euros

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The AREVA group reports first half 2006 sales revenue of 5,036 million euros, up from 4,764 million euros for the same period in 2005, representing 5.7% growth in terms of reported data. Organic growth was 5.1%. In the second quarter 2006 the group had revenue of 2,560 million euros, down 0.7% from second quarter 2005 sales (-1.6% like-for-like). Nuclear operations reported first half 2006 revenue of 3,334 million euros, up 1.6% from the first half of 2005 (+1.3% like-for-like), marked by: net growth of 12.9% for the Front End Division, mainly attributable to uranium deliveries and enrichment services; the contribution from reactor projects in Finland (OL3), China (Ling Ao-Phase II) and France (Flamanville 3 EPR), which boosted sales for the Reactors and Services Division by 2.7%, despite the downturn in sales of reactor services; a 14.4% drop in the Back End Division, primarily in the used fuel treatment business. The Transmission and Distribution Division recorded sales revenue of 1,701 million euros, representing strong organic growth of 13.8%, consistent with the increase in orders booked in the second half of 2005. Orders for the first half of 2006 were up by 17.5% like-for-like compared with those of the first half of 2005. The group is targeting a net increase in revenue for 2006, like-for-like.

  13. Global 30m 2000-2014 Surface Water Dynamics Map Derived from All Landsat 5, 7, and 8

    Science.gov (United States)

    Hudson, A.; Hansen, M.

    2015-12-01

    Water is critical for human life, agriculture, and ecosystems. A better understanding of where it is and how it is changing will enable better management of this valuable resource and guide protection of sensitive ecological areas. Global water maps have typically been representations of surface water at one given time. However, there is both seasonal and interannual variability: rivers meander, lakes disappear, floods arise. To address this ephemeral nature of water, in this study University of Maryland has developed a method that analyzes every Landsat 5, 7, and 8 scene from 1999-2015 to produce global seasonal maps (Winter, Spring, Summer, Fall) of surface water dynamics from 2000-2014. Each Landsat scene is automatically classified into land, water, cloud, haze, shadow, and snow via a decision tree algorithm. The land and water observations are aggregated per pixel into percent occurrence of water in a 3 year moving window for each meteorological season. These annual water percentages form a curve for each season that is discretized into a continuous 3 band RGB map. Frequency of water observation and type of surface water change (loss, gain, peak, or dip) is clearly seen through brightness and hue respectively. Additional data layers include: the year the change began, peak year, minimum year, and the year the change process ended. Currently these maps have been created for 18 1°x1° test tiles scattered around the world, and a portion of the September-November map over Bangladesh is shown below. The entire Landsat archive from 1999-2015 will be processed through a partnership with Google Earth Engine to complete the global product in the coming months. In areas where there is sufficient satellite data density (e.g. the United States), this project could be expanded to 1984-2015. This study provides both scientific researchers and the public an understandable, temporally rich, and globally consistent map showing surface water changes over time.

  14. INCIDENCE OF, AND RISK FACTORS FOR, MALNUTRITION AMONG CHILDREN AGED 5-7 YEARS IN SOUTH INDIA.

    Science.gov (United States)

    Jeyaseelan, Visalakshi; Jeyaseelan, Lakshmanan; Yadav, Bijesh

    2016-05-01

    Protein-energy malnutrition is a major health problem contributing to the burden of disease in developing countries. The aim of this study was to assess the incidence of, and risk factors for, malnutrition among school-going children in south India. A total of 2496 children aged 5-7 years from rural and urban areas of south India were recruited in 1982 and followed up for malnutrition over a period of 9 years. Their body heights and weights were measured every six months and socio-demographic factors such as mother's education and father's education and relevant household characteristics and hygiene practices collected. Body mass index and height-for-age z-scores were used to determine children's levels of underweight and stunting, respectively, classified as normal, mild/moderate or severe. Risk factor analysis was done for pre-pubertal ages only using Generalized Estimating Equations with cumulative odds assumption. There was a significant difference between male and female children in the incidence of severe underweight and stunting (6.4% and 4.2% respectively). Children in households with no separate kitchen had 1.3 (1.0-1.6) times higher odds of being severely underweight (p=0.044) compared with those with a kitchen. Children without a toilet facility had significantly higher odds of severe underweight compared with those who did. Children with illiterate parents had higher odds of severe stunting than those with literate parents. In conclusion, the prevalence of malnutrition among these south Indian children has not changed over the years, and the incidence of severe malnutrition was highest in children when they were at pubertal age. The risk factors for stunting were mostly poverty-related, and those for underweight were mostly hygiene-related. Adolescent children in south India should be screened periodically at school for malnutrition and provided with nutritional intervention if necessary.

  15. Títulos e temas de 1 Cor 6,12-20 na unidade dos capítulos 5-7 = Titles and themes of 1 cor 6.12 -20 in theunity of the chapters 5-7

    Directory of Open Access Journals (Sweden)

    Oliveira, Flávio Martinez de

    2011-01-01

    Full Text Available Apresentam-se os títulos mais encontrados em 1 Cor 6,12-20 e na unidade dos capítulos 5-7. Expõem-se as propostas de articulação da perícope na unidade para propor, a partir de tais títulos e articulação, lendo a perícope, os temas aí considerados centrais. Tais temas são uma proposta de teologia bíblica para a perícope em seu contexto. Esta inspira a existência corporal cristã, tema da tese do autor, onde introduz e motiva a exegese lá exposta. Os temas escolhidos na perícope são porneia e corpo, pecado contra o corpo, corpo de Cristo e templo do Espírito Santo. São alternativas mutuamente excludentes o contato sexual com a prostituta, que implica a inteira existência corporal, e a pertença ao corpo de Cristo, no qual somos inseridos pelo Espírito Santo, do qual somos o templo. Identidade, estilo de vida e comportamento cristãos, teologia e ética são inseparáveis. Estas relações não eram compreendidas por muitos coríntios, os quais Paulo tem em vista. O corpo é central na perícope, perpassa toda a Primeira Carta aos Coríntios e relaciona-se ao próprio Evangelho de Paulo enquanto teologia do corpo. A porneia envolve a pessoa inteira de maneira estável e é um dos problemas que colocam a comunidade em conflito, ao lado de outras controvérsias conhecidas, e com esta relacionadas, como aquelas referentes aos carismas, à idolatria e à própria autoridade de Paulo

  16. "Goltsman Ballet" начинает обучать малышей

    Index Scriptorium Estoniae

    2014-01-01

    Tantsutrupp Goltsman Ballet asutaja, kunstilise juhi ja tänapäevase balletikunsti pedagoog Maria Goltsmani sõnul hakkab tantsutrupp andma tantsutunde 5-7-aastastele lastele, esialgu Tallinnas. Detsembri lõpus esitles Goltsman Ballet uut tantsuetendust "Blue", lavastajaks Krista Köster

  17. Goltsman Ballet hakkab lapsi õpetama

    Index Scriptorium Estoniae

    2014-01-01

    Tantsutrupp Goltsman Ballet asutaja, kunstilise juhi ja tänapäevase balletikunsti pedagoog Maria Goltsmani sõnul hakkab tantsutrupp andma tantsutunde 5-7-aastastele lastele, esialgu Tallinnas. Detsembri lõpus esitles Goltsman Ballet uut tantsuetendust "Blue", lavastajaks Krista Köster

  18. Goltsman Ballet hakkab lapsi õpetama

    Index Scriptorium Estoniae

    2014-01-01

    Tantsutrupp Goltsman Ballet asutaja, kunstilise juhi ja tänapäevase balletikunsti pedagoog Maria Goltsmani sõnul hakkab tantsutrupp andma tantsutunde 5-7-aastastele lastele, esialgu Tallinnas. Detsembri lõpus esitles Goltsman Ballet uut tantsuetendust "Blue", lavastajaks Krista Köster

  19. "Goltsman Ballet" начинает обучать малышей

    Index Scriptorium Estoniae

    2014-01-01

    Tantsutrupp Goltsman Ballet asutaja, kunstilise juhi ja tänapäevase balletikunsti pedagoog Maria Goltsmani sõnul hakkab tantsutrupp andma tantsutunde 5-7-aastastele lastele, esialgu Tallinnas. Detsembri lõpus esitles Goltsman Ballet uut tantsuetendust "Blue", lavastajaks Krista Köster

  20. EPR studies of free radicals in A-2058 human melanoma cells treated by valproic acid and 5,7-dimethoxycoumarin.

    Science.gov (United States)

    Zdybel, Magdalena; Chodurek, Ewa; Pilawa, Barbara

    2014-01-01

    Free radicals in A-2058 human melanoma cells were studied by the use of electron paramagnetic resonance (EPR) spectroscopy. The aim of this work was to determine the changes in relative free radical concentrations in tumor A-2058 cells after treatment by valproic acid (VPA) and 5,7-dimethoxycoumarin (DMC). The influences of VPA and DMC on free radicals in A-2058 cells were compared with those for human melanoma malignum A-375 and G-361 cells, which were tested by us earlier. Human malignant melanoma A-2058 cells were exposed to interactions with VPA, DMC, and both VPA and DMC. The tumor cells A-2058 were purchased from LGC Standards (Lomianki, Poland), and they were grown in the standard conditions: at 37°C and in an atmosphere containing 95% air and 5% CO2, in the Minimum Essential Medium Eagle (MEM, Sigma-Aldrich). The A-2058 cells were incubated with VPA (1 mM) and DMC (10 μM) for 4 days. The first-derivative EPR spectra of the control A-2058 cells, and the cells treated with VPA, DMC, and both VPA and DMC, were measured by the electron paramagnetic resonance spectrometer of Radiopan (Poznań, Poland) with microwaves from an X-band (9.3 GHz). The parameters of the EPR lines: amplitudes (A), integral intensities (I), line widths (ΔBpp), and g-factors, were analyzed. The changes of amplitudes and line widths with microwave power increasing from 2.2 to 70 mW were drawn evaluated, o-Semiquinone free radicals of melanin biopolymer are mainly responsible for the EPR lines of A-2058 melanoma malignum cells. The amounts of free radicals in A-2058 cells treated with VPA, and both VPA and DMC, were lower than in the untreated control cells. Application of the tested substances (VPA, and both VPA and DMC) as the antitumor compounds was discussed. DMC without VPA did not decrease free radicals concentration in A-2058 cells. The studies con-firmed that EPR spectroscopy may be used to examine interactions of free radicals with antitumor compounds.

  1. The Lyman-alpha luminosity function at z=5.7-6.6 and the steep drop of the faint end: implications for reionization

    CERN Document Server

    Santos, Sérgio; Matthee, Jorryt

    2016-01-01

    We present new results from the widest narrow band survey search for Lyman-alpha (Lya) emitters at z=5.7, just after reionization. We survey a total of 7 deg$^2$ spread over the COSMOS, UDS and SA22 fields. We find over 11,000 line emitters, out of which 514 are robust Lya candidates at z=5.7 within a volume of 6.3x10$^6$ Mpc$^3$. Our Lya emitters span a wide range in Lya luminosities, from faint to bright (L$_{\\rm Ly\\alpha}\\sim10^{42.5-44}$ erg s$^{-1}$) and rest-frame equivalent widths (EW$_0$~25-1000 \\AA) in a single, homogeneous data-set. By combining all our fields we find that the faint end slope of the z=5.7 Lya luminosity function is very steep, with $\\alpha=-2.3^{+0.4}_{-0.3}$. We also present an updated z=6.6 Lya luminosity function, based on comparable volumes and obtained with the same methods, which we directly compare with that at z=5.7. We find a significant decline of the number density of faint Lya emitters from z=5.7 to z=6.6 (by $0.5\\pm0.1$ dex), but no evolution at the bright end/no evolut...

  2. 南京"5.7"192Ir源放射事故患者的营养治疗%Nutrition treatment scheme for a patient exposed to Nanjing "5.7" 192Ir source accident

    Institute of Scientific and Technical Information of China (English)

    陈学英; 刘玉龙; 王优优; 蔡梅芝; 黄威威; 洪秀秀; 赵斯迪

    2016-01-01

    目的 通过对南京“5.7”192Ir源放射事故患者全程救治中的营养治疗,探讨放射损伤患者的营养治疗方案.方法 在不同救治阶段,对患者进行膳食调查和监测相关营养指标包括体重、体质量指数(BMI)、血常规、血生化指标等,并使用代谢车测定患者静息能量消耗值,为患者制订不同的营养治疗方案.结果 患者入院时(受照后第5天)体重42.5 kg,受照后第172天(首次植皮术后)下降至最低为36 kg,此后逐渐回升,出院时(受照后第383天)体重基本恢复.血红蛋白入院时正常为135 g/L,受照后第172天降至最低为54 g/L,出院时恢复正常;淋巴细胞入院时偏低为0.5×109/L,受照后第58天恢复正常,受照后第172天降至最低为0.4 × 109/L,出院时恢复正常.血清白蛋白入院时正常为41.2 g/L,受照后第172天降到最低为25.3 g/L,出院时恢复正常;血清前白蛋白入院时正常为0.22 g/L,受照第248天降至最低为0.04 g/L,出院时基本恢复正常为0.17 g/L.肝功能指标入院时正常,胆红素指标略偏高,进行“全合一”肠外营养后约2.5个月后,肝功能指标和胆红素指标均逐渐升高,经调整营养治疗方案及保肝利胆等治疗后逐渐恢复正常.受照后第294、308和342天使用代谢车测得患者的静息能量消耗值,据此确定患者当日热能需要量.结论 合理营养治疗可以有效改善放射损伤患者的全身营养状况及临床疗效,是放射损伤临床救治的关键手段之一.%Objective To provide nutritional supportive scheme for patients with radiation injury through the treatment of the one exposed to Nanjing 192Ir source accident.Methods The reasonable nutrition treatment scheme was made on the basis of dietary survey and nutritional index monitoring during clinical stages of the patient,including body weight,body mass index(BMI),biochemical indexes,electrolyte,etc.,as well as metabolic cart determination of resting energy

  3. Changes in firing rate and firing pattern of midbrain dopaminergic neurons after lesioning of the dorsal raphe nucleus by 5,7-drhydroxytryptamine in adult rats

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective To study the effect of serotonergic efferent projection of the dorsal raphe nucleus(DRN)on the activity of substantia nigra pars compacta(SNc)and ventral tegmenta area(VTA)dopaminergic neurons after lesioning of the DRN by the neurotoxin 5,7-drhydroxytryptamine(5,7-DHT)in rat.Methods The changes in the firing rate and firing pattern of SNc and VTA dopaminergic neurons were observed with extracellular recording in control and the lesioned rats.Results The results showed that the mean firing rates o...

  4. 5,7-DHT lesion of the dorsal raphe nuclei impairs object recognition but not affective behavior and corticosterone response to stressor in the rat.

    Science.gov (United States)

    Lieben, Cindy K J; Steinbusch, Harry W M; Blokland, Arjan

    2006-04-03

    Previous studies with acute tryptophan depletion, leading to transient central 5-HT reductions, showed no effects on affective behavior but impaired object memory. In the present study, the behavioral effects of a 5,7-dihydroxytryptamine (5,7-DHT) lesion in the dorsal raphe were evaluated in animal models of anxiety (open field test), depression (forced swimming test), behavioral inhibition (discrete fixed interval test) and cognition (object recognition task). The corticosterone response to a stress condition was examined at several intervals after 5,7-DHT treatment. The substantial reduction in neuronal 5-HT markers in the dorsal raphe did not affect anxiety-related, depressive-like or impulsive behavior. Compared to the SHAM group, the lesioned rats showed a lower response latency to obtain a reward, indicating a quick and accurate reaction to a stimulus. No differences were found in the progressive ratio test for food motivation. A marked impairment in object recognition was found. The 5,7-DHT treatment did not affect the corticosterone response to a stressful situation. Overall, these results corroborate studies with acute tryptophan depletion suggesting a role of 5-HT in object memory, but not affective behavior.

  5. The 2 1Ag state of isolated cis-trans-1,3,5,7-octatetraene: two-color resonance enhanced two-photon ionization studies

    NARCIS (Netherlands)

    B.E. Kohler; T. Shaler; W.J. Buma

    1992-01-01

    Vibrationally resolved 1 1Ag2 1Ag excitation spectra and decay times for cis,trans-1,3,5,7-octatetraene seeded in a supersonic He expansion have been measured by two-color resonance enhanced two-photon ionization spectroscopy. The excitation energy of the 1 1Ag2 1Ag 0-0 band (29 035 cm-1 ) is ~6500

  6. Straightforward synthesis of 2,2,4,4,5,7,7-d{sub 7}-cholestane: a new deuterated standard in petroleum analysis

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, Maicon Guerra de; Albert, Andre Luis Mazzei; Cardoso, Jari Nobrega; Lopes, Rosangela Sabbatini Capella; Lopes, Claudio Cerqueira, E-mail: maicon_iq@yahoo.com [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica

    2013-10-01

    A short and efficient synthesis of heptadeuterated 2,2,4,4,5,7,7-d7-cholestane (1) from cholesterol (3) is described. The deuterated material will be useful for the analysis of different sources of petroleum in analytical geochemistry laboratories as internal standard for quantification of steranes via gas chromatography-mass spectrometry (GC-MS). (author)

  7. Determination of 5,7-dichloroquinolin-8-ol and 5-chloroquinolin-8-ol in bulk drug powder and pharmaceutical preparation by TLC

    Directory of Open Access Journals (Sweden)

    B H Pavithra

    2011-01-01

    Full Text Available Aim: The study aims to develop a simple, rapid and economical normal phase thin layer chromatography (TLC method for identification and quantification of 5,7-dichloroquinolin-8-ol and 5-chloroquinolin-8-ol, two active ingredients of halquinol, an antimicrobial agent. Materials and Methods: The analysis was performed on silica gel 60 TLC plates pre-washed with disodium ethylenedinitrilotetraacetic acid disodium salt (Na 2 EDTA solution with methanol-ethyl acetate-iso-propyl alcohol-ammonia solution [8:20:1:0.6 (v/v] as the mobile phase. Detection and quantification was performed densitometrically at 247 nm. Results: Responses of both 5,7-dichloroquinolin-8-ol and 5-chloroquinolin-8-ol were linear functions of concentration in the range of 300-800 ng. The intraday precision and intermediate precision of the method for 5,7-dichloroquinolin-8-ol and 5-chloroquinolin-8-ol was determined and it was found to be precise. Conclusion: The TLC method developed for simultaneous quantitative determination of 5,7-dichloroquinolin-8-ol and 5-chloroquinolin-8-ol was found to be simple and economical. Therefore, it can be used in routine quality control analysis of halquinol in bulk drug powder and halquinol bolus.

  8. Plaswekker ook succesvol bij 5-7-jarigen met enuresis nocturna [Alarm treatment also successful in children aged 5 to 7 years with nocturnal enuresis

    NARCIS (Netherlands)

    Zwet, J.M.L. van; Wiertz, Y.D.B.M.; Bolk-Bennink, L.F.; Leerdam, F.J.M. van; Hirasing, R.A.

    1998-01-01

    Objective. To determine how many bed-wetting children aged 5-7 years unlearn the habit using the alarm treatment. Design. Descriptive. Setting. TNO Prevention and Health, Leiden, the Netherlands. Methods. The population consisted of all children aged 5 to 7 with nocturnal enuresis (defined as ≤ 2 we

  9. Neonatal co-lesion by DSP-4 and 5,7-DHT produces adulthood behavioral sensitization to dopamine D(2) receptor agonists.

    Science.gov (United States)

    Nowak, Przemysław; Nitka, Dariusz; Kwieciński, Adam; Jośko, Jadwiga; Drab, Jacek; Pojda-Wilczek, Dorota; Kasperski, Jacek; Kostrzewa, Richard M; Brus, Ryszard

    2009-01-01

    To assess the possible modulatory effects of noradrenergic and serotoninergic neurons on dopaminergic neuronal activity, the noradrenergic and serotoninergic neurotoxins DSP-4 N-(2-chlorethyl)-N-ethyl-2-bromobenzylamine (50.0 mg/kg, sc) and 5,7-dihydroxytryptamine (5,7-DHT) (37.5 microg icv, half in each lateral ventricle), respectively, were administered toWistar rats on the first and third days of postnatal ontogeny, and dopamine (DA) agonist-induced behaviors were assessed in adulthood. At eight weeks, using an HPLC/ED technique, DSP-4 treatment was associated with a reduction in NE content of the corpus striatum (> 60%), hippocampus (95%), and frontal cortex (> 85%), while 5,7-DHT was associated with an 80-90% serotonin reduction in the same brain regions. DA content was unaltered in the striatum and the cortex. In the group lesioned with both DSP-4 and 5,7-DHT, quinpirole-induced (DA D(2) agonist) yawning, 7-hydroxy-DPAT-induced (DA D(3) agonist) yawning, and apomorphine-induced (non-selective DA agonist) stereotypies were enhanced. However, SKF 38393-induced (DA D(1) agonist) oral activity was reduced in the DSP-4 + 5,7-DHT group. These findings demonstrate that DA D(2)- and D(3)-agonist-induced behaviors are enhanced while DA D(1)-agonist-induced behaviors are suppressed in adult rats in which brain noradrenergic and serotoninergic innervation of the brain has largely been destroyed. This study indicates that noradrenergic and serotoninergic neurons have a great impact on the development of DA receptor reactivity (sensitivity).

  10. Facile and efficient synthesis of 5, 7-disubstituted thiazolo [5,4-d] pyrimidine-4, 6 (5H, 7H)-diones

    Institute of Scientific and Technical Information of China (English)

    Liang Chen; Zhan Mei Li; Jie Zhou; Hong Rui Song; Bai Ling Xu

    2012-01-01

    A facile and efficient approach was developed to access 5,7-disubstitued thiazolo[5,4-d]pyrimidine-4,6(5H,7H)-diones through condensation of N-substituted 5-amino-4-carbethoxythiazole with structurally diverse isocyanates in the presence of sodium hydride.The easy availability of substrates and tolerance of structural diversity in this reaction make it attractive to he used for constnuction of libraries in drug discovery process.

  11. Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage

    OpenAIRE

    Dan-Dan Zhang; Hong Zhang; Yuan-zhi Lao; Rong Wu; Jin-wen Xu; Ferid Murad; Ka Bian; Hong-Xi Xu

    2015-01-01

    Garcinia Linn. plants having rich natural xanthones and benzophenones with anti-inflammatory activity attracted a great deal of attention to discover and develop them as potential drug candidates. Through screening targeting nitric oxide accumulation in stimulated macrophage, we found that 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (TIE) had potential anti-inflammatory effect. To understand how TIE elicits its anti-inflammatory activity, we uncovered that it significantly inhibits the productio...

  12. How long should umbilical venous catheters remain in place in neonates who require long-term (≥5-7 days) central venous access?

    Science.gov (United States)

    Keir, Amy; Giesinger, Regan; Dunn, Michael

    2014-08-01

    In this evidenced-based review, we examine the current available literature to help answer the question 'In neonates requiring long-term central access [patient], does removal of the umbilical venous catheter (UVC) on days 5-7 and replacement with a peripherally inserted central catheter line [intervention] compared with leaving the UVC in situ [comparison] reduce rates of central line-associated bloodstream infections [outcome]?'

  13. Synthesis of 3,7-Dinitro-1,3,5,7-tetraazabicyclo-[3,3,1]nonane (DPT Using Task-Specific Ionic Liquids as Recoverable Catalysts

    Directory of Open Access Journals (Sweden)

    L. I. U. Xiao Bing

    2011-01-01

    Full Text Available A facile and efficient method for the synthesis of 3,7-dinitro-1,3,5,7-tetraazabicyclo[3,3,1]nonane (DPT has been developed starting from urea. In the procedure some task-specific ionic liquids was synthesized as a cheap and recyclable catalyst for the synthesis of DPT. The catalysts could be recovered and reused several times without noticeably decrease in the catalytic activity.

  14. Validation of analytical procedure for determination of recidual organic solvents for standardization the substance of 5,7-bis-meta-nitrophenylamino-4,6-dinitrobenzofuroxan

    Directory of Open Access Journals (Sweden)

    R. Sh. Markhabullina

    2014-01-01

    Full Text Available The aim of this study was to develop and validate a gas chromatography methods of quantitative determination of residual organic solvents in substance of 5,7-bis-(meta-nitrophenylamino-4,6-dinitrobenzofuroxan. Validation of elaborating methods of quantitative determination of residual organic solvents - ethyl alcohol and acetonitrile in substance of 5,7-bis-(meta-nitrophenylamino-4,6-dinitrobenzofuroxan using gas chromatography method allowed to evaluate their metrology parameters. All parameters of validation characteristics met their acceptance criteria's. Specificity was demonstrated by a complete chromatographic separation of peaks of ethyl alcohol and acetonitrile, and lack of peaks of ethyl alcohol and acetonitrile in the chromatogram of solvent. The linearity was proven in the range of quantitation limit to 120 % of the test concentrations. Precision of the methods comply with the requirement defined - the relative standard deviation for of ethyl alcohol and acetonitrile below 3 %. The results of this validation study prove the suitability of the gas chromatography method for quantitative determination of residual organic solvents in substance of 5,7-bis-(meta-nitrophenylamino-4,6-dinitrobenzofuroxan.

  15. Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli.

    Science.gov (United States)

    Nelson, Andrew J D; Thur, Karen E; Marsden, Charles A; Cassaday, Helen J

    2012-05-01

    There is good evidence that forebrain serotonergic systems modulate cognitive flexibility. Latent inhibition (LI) is a cross-species phenomenon which manifests as poor conditioning to a stimulus that has previously been experienced without consequence and is widely considered an index of the ability to ignore irrelevant stimuli. While much research has focused on dopaminergic mechanisms underlying LI, there is also considerable evidence of serotonergic modulation. However, the neuroanatomical locus of these effects remains poorly understood. Previous work has identified the nucleus accumbens (NAc) as a key component of the neural circuit underpinning LI and furthermore, this work has shown that the core and shell subregions of the NAc contribute differentially to the expression of LI. To examine the role of the serotonergic input to NAc in LI, we tested animals with 5,7-dihydroxytryptamine (5,7-DHT) lesions to the core and shell subregions on LI assessed under experimental conditions that produce LI in shams and subsequently with weak stimulus pre-exposure designed to prevent the emergence of LI in shams. We found that serotonergic deafferentation of the core disrupted LI whereas 5,7-DHT lesions to the shell produced the opposite effect and potentiated LI.

  16. Regeneration of 5-HT fibers in hippocampal heterotopia of methylazoxymethanol-induced micrencephalic rats after neonatal 5,7-DHT injection.

    Science.gov (United States)

    Nakamura, Arata; Kadowaki, Taro; Sakakibara, Shin-ichi; Yoshimoto, Kanji; Hirata, Koichi; Ueda, Shuichi

    2010-03-01

    In order to elucidate the regeneration properties of serotonergic fibers in the hippocampus of methylazoxymethanol acetate (MAM)-induced micrencephalic rats (MAM rats), we examined serotonergic regeneration in the hippocampus following neonatal intracisternal 5,7-dihydroxytryptamine (5,7-DHT) injection. Prenatal exposure to MAM resulted in the formation of hippocampal heterotopia in the dorsal hippocampus. Immunohistochemical and neurochemical analyses revealed hyperinnervation of serotonergic fibers in the hippocampus of MAM rats. After neonatal 5,7-DHT injection, most serotonergic fibers in the hippocampus of 2-week-old MAM rats had degenerated, while a small number of serotonergic fibers in the stratum lacunosum-moleculare (SLM) of the hippocampus and in the hilus adjacent to the granular cell layer of the dentate gyrus (DG) had not. Regenerating serotonergic fibers from the SLM first extended terminals into the hippocampal heterotopia, then fibers from the hilus reinnervated the DG and some fibers extended to the heterotopia. These findings suggest that the hippocampal heterotopia exerts trophic target effects for regenerating serotonergic fibers in the developmental period in micrencephalic rats.

  17. Synthesis and characterization of Ni(II) complex with 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-7,14-dienium bromide

    Energy Technology Data Exchange (ETDEWEB)

    Yusoff, Latifah M.; Yusoff, Siti Fairus M.; Ismail, Wafiuddin; Yamin, Bohari M. [School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)

    2014-09-03

    Nickel(II) complex have been synthesized by treating a 14-membered ring tetraaza macrocyclic compound, 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-7,14-dienium, bromide (Me{sub 6}N{sub 4}H{sub 4})Br{sub 2} with nickel acetate in metanol. The complex was characterized using elemental analysis, Fourier Transform Infrared (FTIR), Ultraviolet-Visible (UV-Vis), and single crystal diffraction (X-ray). The nickel atom coordinates through four nitrogen atoms in the ligand. Square planar geometry has been proposed for this complex.

  18. Synthesis and characterization of Ni(II) complex with 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-7,14-dienium bromide

    Science.gov (United States)

    Yusoff, Latifah M.; Yusoff, Siti Fairus M.; Ismail, Wafiuddin; Yamin, Bohari M.

    2014-09-01

    Nickel(II) complex have been synthesized by treating a 14-membered ring tetraaza macrocyclic compound, 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-7,14-dienium, bromide (Me6N4H4)Br2 with nickel acetate in metanol. The complex was characterized using elemental analysis, Fourier Transform Infrared (FTIR), Ultraviolet-Visible (UV-Vis), and single crystal diffraction (X-ray). The nickel atom coordinates through four nitrogen atoms in the ligand. Square planar geometry has been proposed for this complex.

  19. Synthesis Craft of HMX from 1,5-Methylene-3,7-dintrio-1,3,5,7-tetraazacyclooctane%DPT制备HMX工艺研究

    Institute of Scientific and Technical Information of China (English)

    李全良; 陈军; 王建龙

    2007-01-01

    以乌洛托品为起始原料,合成了中间体3,7-二硝基-1,3,5,7-四氮杂双环[3,3,1]壬烷(DPT),然后以氧化镁、硝酸铵、硝酸为硝解体系,硝解DPT制备出HMX.结果表明:在25 ℃的条件下,反应30 min,收率达60.1%,工艺条件温和,易于控制,反应废液容易处理.

  20. Unsaturated C3,5,7,9-Monocarboxylic Acids by Aqueous, One-Pot Carbon Fixation: Possible Relevance for the Origin of Life

    OpenAIRE

    Christopher Scheidler; Jessica Sobotta; Wolfgang Eisenreich; Günter Wächtershäuser; Claudia Huber

    2016-01-01

    All scientific approaches to the origin of life share a common problem: a chemical path to lipids as main constituents of extant cellular enclosures. Here we show by isotope-controlled experiments that unsaturated C3,5,7,9-monocarboxylic acids form by one-pot reaction of acetylene (C2H2) and carbon monoxide (CO) in contact with nickel sulfide (NiS) in hot aqueous medium. The primary products are toto-olefinic monocarboxylic acids with CO-derived COOH groups undergoing subsequent stepwise hydr...

  1. New synthetic way to prepare 2-aryl-8-(piperidin-4-yl)-5, 7-dimethoxy-4H-chromen-4-one as key intermediate for CDK inhibitor

    Institute of Scientific and Technical Information of China (English)

    Yan Ling Li; Hao Fang; Wen Fang Xu; Bing He Wang

    2008-01-01

    As an important intermediate to study cyclin-dependent kinase (CDK) inhibitors, 2-aryl-8-(piperidin-4-yl)-5,7-dimethoxy-4H-chromen-4-one derivatives were prepared using β-diketone route with low yield. In our study, chalcone route has been investigatedand the result suggested that the benzaldehydes substituted with electron-donating group give much better yield than β-diketoneroute. This new method will be an efficient way to start further research on new anticancer flavonoids.2008 Hao Fang. PuNished by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  2. Novel 1,5,7-trihydroxy-3-hydroxy methyl anthraquinone isolated from terrestrial Streptomyces sp. (eri-26) with antimicrobial and molecular docking studies.

    Science.gov (United States)

    Duraipandiyan, V; Al-Dhabi, N A; Balachandran, C; Raj, M Karunai; Arasu, M Valan; Ignacimuthu, S

    2014-11-01

    Streptomyces sp. isolate ERI-26 was obtained from the Nilgiris forest soil of Western Ghats, Tamil Nadu, India. Novel anthraquinone compound was isolated from the active fraction 5; it was identified by spectroscopical data using UV, IR, NMR and MASS. The isolated compound 1,5,7-trihydroxy-3-hydroxy methyl anthraquinone was tested against bacteria and fungi at minimum inhibitory concentration level. The compound showed significant antimicrobial activity against bacteria, Staphylococcus aureus at 125 μg/ml, Staphylococcus epidermidis at 62.5 μg/m, Bacillus subtilis at 31.25 μg/ml, fungi; Epidermophyton floccosum at 62.5 μg/ml, Aspergillus niger at 31.25 μg/ml, Aspergiller flavus at 31.25 μg/ml, Trichophyton rubrum at 62.5 μg/ml and Botrytis cinerea at 62.5 μg/ml. The isolated compound was subjected to molecular docking studies for the inhibition of TtgR, topoisomerase IV and AmpC β-lactamase enzymes which are targets for antimicrobials. Docking studies of the compound showed low docking energy indicating its usefulness as antimicrobial agent. 1,5,7-Trihydroxy-3-hydroxy methyl anthraquinone is new, and its antimicrobial and molecular docking properties are reported for the first time.

  3. Selective ablation of WHHLMI rabbit atherosclerotic plaque by quantum cascade laser in the 5.7 μm wavelength range for less-invasive laser angioplasty

    Science.gov (United States)

    Hashimura, Keisuke; Ishii, Katsunori; Akikusa, Naota; Edamura, Tadataka; Yoshida, Harumasa; Awazu, Kunio

    2013-06-01

    We investigated the potential of a compact and high-power quantum cascade laser (QCL) in the 5.7 μm wavelength range for less-invasive laser angioplasty. Atherosclerotic plaques consist mainly of cholesteryl esters. Radiation at a wavelength of 5.75 μm is strongly absorbed in C=O stretching vibration mode of cholesteryl esters. Our previous study achieved to make cutting differences between a normal artery and an atherosclerotic lesions using nanosecond pulsed laser by difference-frequency generation (DFG laser) at the wavelength of 5.75 μm. For applying this technique to clinical treatment, a compact laser device is required. In this study, QCL irradiation effects to a porcine normal aorta were compared with DFG laser. Subsequently, QCL irradiation effects on an atherosclerotic aorta of myocardial infarction-prone Watanabe heritable hyperlipidemic rabbit (WHHLMI rabbit) and a normal rabbit aorta were observed. As a result, the QCL could make cutting differences between the rabbit atherosclerotic and normal aortas. On the other hand, the QCL induced more thermal damage to porcine normal aorta than the DFG laser at the irradiation condition of comparable ablation depths. In conclusion, the possibility of less-invasive and selective treatment of atherosclerotic plaques using the QCL in the 5.7 μm wavelength range was revealed, although improvement of QCL was required to prevent the thermal damage of a normal artery.

  4. Constraining the Age and Distance of the Galactic Supernova Remnant G156.2+5.7 by H-alpha Expansion Measurements

    CERN Document Server

    Katsuda, Satoru; Morokuma, Tomoki; Fesen, Robert; Milisavljevic, Dan

    2016-01-01

    We present deep H-alpha images of portions of the X-ray bright but optically faint Galactic supernova remnant G156.2+5.7, revealing numerous and delicately thin nonradiative filaments which mark the location of the remnant's forward shock. These new images show that these filaments have a complex structure not visible on previous lower resolution optical images. By comparing H-alpha images taken in 2004 at the McDonald Observatory and in 2015-2016 at the Kiso Observatory, we set a stringent 1-sigma upper limit of expansion to be 0.06 arcsec/yr. This proper motion, combined with a shock speed of 500 km/s inferred from X-ray spectral analyses, gives a distance of > 1.7 kpc. In addition, a simple comparison of expansion indices of several SNRs allows us to infer the age of the remnant to be a few 10,000 yr old. These estimates are more straightforward and reliable than any other previous studies, and clearly rule out a possibility that G156.2+5.7 is physically associated with part of the Taurus-Auriga cloud and ...

  5. Baseline oxidative defense and survival after 5-7 years among elderly stroke patients at nutritional risk: Follow-up of a randomized, nutritional intervention trial.

    Science.gov (United States)

    Iversen, Per O; Ha, Lisa; Blomhoff, Rune; Hauge, Truls; Veierød, Marit B

    2015-08-01

    Patients at nutritional risk are particularly vulnerable to adverse outcomes of acute stroke. We previously found that increased energy- and protein intervention improved short-term survival among stroke patients with the highest baseline antioxidant capacity. We now examined survival of these patients after 5-7 years. We studied 165 patients >65 years admitted to hospital for acute stroke and enrolled in a randomized nutritional intervention study in 2005-2007. Cox regression analysis was used to estimate the associations between all-cause mortality (through 2011) and baseline plasma levels of antioxidant markers (glutathione reducing capacity, alpha-tocopherol, vitamin C and total carotenoids). We found no significant difference (P = 0.86) in survival between the intervention and control group. Among the tested antioxidant markers, plasma levels above the median for total carotenoids were associated with reduced risk of death in the intervention group (adjusted hazard ratio, 0.29; 95% confidence interval, 0.12-0.71). Hospitalized patients that received enhanced dietary energy- and protein after acute stroke and with baseline plasma total carotenoids above median level, had reduced risk of death after 5-7 years. Further trials testing intervention with diets rich in antioxidants are warranted. Copyright © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  6. Platinum(II) complexes with 5,7-disubstituted-1,2,4-triazolo [1,5-a]pyrimidines: Spectroscopical characterization and cytotoxic activity in vitro

    Science.gov (United States)

    Łakomska, Iwona; Fandzloch, Marzena; Popławska, Beata; Sitkowski, Jerzy

    2012-06-01

    Complexes of the types: cis-[PtI2(dptp)2] (1), cis-[PtI2(NH3)(dptp)] (2), trans-[PtI2(dptp)(dmso)] (3) and trans-[PtI2(dbtp)(dmso)] (4), where dptp = 5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine (dptp), dbtp = 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine have been synthesized and characterized by infrared and multinuclear magnetic resonance spectroscopic techniques (1H, 13C, 15N, 195Pt). In 195Pt NMR, the cis-diiodo complexes were observed between -2601 ppm and -3261 ppm, while the trans coordination compounds were found at higher field (ca. -4389 ppm). In all cases significant 15N NMR shielding (92-95 ppm) were observed for N(3) atom indicating this nitrogen atom as a coordination site. The cis complexes have been assayed for antitumor activity in vitro against two human cell lines: A549 (non-small cell lung carcinoma) and T47D (breast cancer). The results indicate a moderate antiproliferative activity of (2) against human cancer lines.

  7. Evaluation of severity of dental caries in primary teeth among children 5-7 years-old in Tehran in 2016

    Directory of Open Access Journals (Sweden)

    Hossein Hessari

    2017-02-01

    Full Text Available Background and Aims: This study aimed to assess the severity of tooth decay and related factors in children 5-7 years old, in 2016, in Tehran. Materials and Methods: A descriptive and cross-sectional study was performed on 572 children aged 5-7 years old (300 girls and 272 boys in public schools in Tehran, Iran. Severity of dental caries (number of decayed, missing, filled surfaces recorded for C, D and E teeth according to WHO criteria. Data analysis was performed by Backward Linear Regression Analyses using SPSS 20 (P≤0.05. Results: Assessment of dental caries severity according to the number of decayed surfaces showed generally higher figures in upper jaw. The order of average severity of carious teeth was C, E and D from low to high in both jaws. According to the results of Linear Regression Analysis, severity of dental caries was more than other children in boys (OR=1.83, 95%CI: 0.81-2.8, those visited dentist due to dental problems associated with pain (OR=1.17, 95%CI: 0.73-1.6, and those without fluoride therapy (OR=1.64, 95%CI: 0.58-2.6 in C, D and E teeth. Conclusion: Flow the results, it was concluded that gender, level of mother's education, type of snack consumption, start age of tooth brushing, reason for dental visit and fluoride therapy affected severity of tooth decay.

  8. High-Resolution Numerical Analysis of the Triggering Mechanism of M L5.7 Aswan Reservoir Earthquake Through Fully Coupled Poroelastic Finite Element Modeling

    Science.gov (United States)

    Cheng, Huihong; Zhang, Huai; Shi, Yaolin

    2016-05-01

    In 1981, a powerful M L5.7 earthquake occurred 50 km away from the Aswan Reservoir dam. After the statistical analysis on the correlationship between long-term continuous seismicity occurrence and the reservoir water level variation attributed to the impoundment and drainage procedures, researchers believe that this event is a typical reservoir-triggered seismicity (Nature 301(6):14, 1983; Earthquake Activity in the Aswan Region, Egypt. Birkhäuser, Basel, pp. 69-86, 1995), although its triggering mechanism is poorly understood to date. To quantitatively address the triggering mechanism as well as its relationship with the characteristics of local geological settings around the reservoir region, in this paper, a fully coupled three-dimensional poroelastic finite element model of the Aswan reservoir is put forward by taking the consideration of the realistic observation data, for example, the high-resolution topography, water level fluctuation history, flood zone boundary and water depth variation, fault parameters, etc. Meanwhile, the change of Coulomb Failure Stress (ΔCFS) in correspondence to elastic stress and pore pressure variations induced by fluid diffusion is calculated. And the elastic strain energy accumulation in the reservoir region due to the impoundment load is obtained as well. Our primary results indicate that both the pore pressure and the coulomb stress on the seismogenic fault plane gradually increase with the respect of time while the water level rises. The magnitude of ΔCFS at the hypocenter of this major event is around 0.1 MPa, suggesting that the impoundment of the Aswan Reservoir possibly triggered the M L5.7 earthquake. The contribution of the elastic load is less than 3 percent of the total ΔCFS; on the other hand, the dynamic pore pressure change predominantly accounts for the contribution. The accumulative maximum surface deformation beneath the Aswan reservoir is up to 80 cm since its impounding began until the M L5.7 earthquake

  9. Synthesis,characterization,and biological activities of Pt(Ⅱ) and Pd(Ⅱ)complexes with 2',3',4',5,7-pentahydroxy flavone

    Institute of Scientific and Technical Information of China (English)

    TANG Hui'An; WANG Xiaofang; YANG Sheng; WANG Liufang

    2004-01-01

    Pt(Ⅱ) and Pd(Ⅱ) complexes with 2',3',4',5,7-pentahydroxy-flavone were synthesized and characterized by elemental analysis, molar conductance, IR, 1HNMR, TG-DTA, UV-Vis spectroscopic techniques, and fluorescence analysis.The scavenging effect on the superoxide radical ( O-2 ) and the inhibitory effect on lipid peroxides were also investigated.Both the ligand and the complexes exhibit scavenging effect on superoxide radicals, and the effect of the complexes is greater than that of the ligand. The Pt(Ⅱ) complex exhibits the strongest scavenging efficiency. Both Pt(Ⅱ) and Pd(Ⅱ) complexes have the inhibitory effect on lipid peroxides, and the effect of the complexes is greater than that of the ligand, but the Pt(Ⅱ) complex has a high effect of promoting lipid peroxides.

  10. Cyanide anion sensing mechanism of 1,3,5,7-tetratolyl aza-BODIPY: Intramolecular charge transfer and partial configuration change

    Science.gov (United States)

    Bhat, Haamid R.; Jha, Prakash C.

    2017-02-01

    The cyanide anion sensing mechanism of 1,3,5,7-tetratolyl aza-BODIPY (1) has been rigorously investigated using density functional theory and time dependent-density functional theory methods. Mulliken charge distribution and Natural Bond Orbital analysis reveals that cyanide addition may occur at both electrophilic centers with equal probability. The molecular orbital analysis reveals that first excited state (S1) of 1 is a local excited state with π-π∗ transition, whereas for 2 (the cyano form of 1), S1 , a charge-separation state, is found to be responsible for the intramolecular charge transfer (ICT) process which in conjunction with partial configuration change induces fluorescence stimulation in 2.

  11. Organizational strategy use in children aged 5-7: standardization and validity of the Rey Complex Figure Organizational Strategy Score (RCF-OSS).

    Science.gov (United States)

    Martens, R; Hurks, P P M; Jolles, J

    2014-01-01

    This study investigated psychometric properties (standardization and validity) of the Rey Complex Figure Organizational Strategy Score (RCF-OSS) in a sample of 217 healthy children aged 5-7 years. Our results showed that RCF-OSS performance changes significantly between 5 and 7 years of age. While most 5-year-olds used a local approach when copying the Rey-Osterrieth Complex Figure (ROCF), 7-year-olds increasingly adopted a global approach. RCF-OSS performance correlated significantly, but moderately with measures of ROCF accuracy, executive functioning (fluency, working memory, reasoning), and non-executive functioning (visual-motor integration, visual attention, processing speed, numeracy). These findings seem to indicate that RCF-OSS performance reflects a range of cognitive skills at 5 to 7 years of age, including aspects of executive and non-executive functioning.

  12. Target and Beam-Target Spin Asymmetries in Exclusive $\\pi^+$ and $\\pi^-$ Electroproduction with 1.6 to 5.7 GeV Electrons

    CERN Document Server

    Bosted, P E; Careccia, S; Dodge, G; Fersch, R; Kuhn, S E; Pierce, J; Prok, Y; Zheng, X; Adhikari, K P; Adikaram, D; Akbar, Z; Amaryan, M J; Pereira, S Anefalos; Asryan, G; Avakian, H; Badui, R A; Ball, J; Baltzell, N A; Battaglieri, M; Batourine, V; Bedlinskiy, I; Boiarinov, S; Briscoe, W J; Bültmann, S; Burkert, V D; Cao, T; Carman, D S; Celentano, A; Chandavar, S; Charles, G; Chetry, T; Ciullo, G; Clark, L; Colaneri, L; Cole, P L; Contalbrigo, M; Cortes, O; Crede, V; D'Angelo, A; Dashyan, N; De Vita, R; Deur, A; Djalali, C; Dupre, R; Egiyan, H; Alaoui, A El; Fassi, L El; Eugenio, P; Fanchini, E; Fedotov, G; Filippi, A; Fleming, J A; Forest, T A; Fradi, A; Garçon, M; Gevorgyan, N; Ghandilyan, Y; Gilfoyle, G P; Giovanetti, K L; Girod, F X; Gleason, C; Gohn, W; Golovatch, E; Gothe, R W; Griffioen, K A; Guo, L; Hafidi, K; Hanretty, C; Harrison, N; Hattawy, M; Heddle, D; Hicks, K; Holtrop, M; Hughes, S M; Ilieva, Y; Ireland, D G; Ishkhanov, B S; Isupov, E L; Jenkins, D; Jiang, H; Jo, H S; Joo, K; Joosten, S; Keller, D; Khandaker, M; Kim, W; Klein, A; Klein, F J; Kubarovsky, V; Kuleshov, S V; Lanza, L; Lenisa, P; Livingston, K; Lu, H Y; MacGregor, I J D; Markov, N; McCracken, M E; McKinnon, B; Meyer, C A; Minehart, R; Mirazita, M; Mokeev, V; Movsisyan, A; Munevar, E; Camacho, C Munoz; Nadel-Turonski, P; Net, L A; Ni, A; Niccolai, S; Niculescu, G; Niculescu, I; Osipenko, M; Ostrovidov, A I; Paremuzyan, R; Park, K; Pasyuk, E; Peng, P; Phelps, W; Pisano, S; Pogorelko, O; Price, J W; Procureur, S; Protopopescu, D; Puckett, A J R; Raue, B A; Ripani, M; Rizzo, A; Rosner, G; Rossi, P; Roy, P; Sabatié, F; Salgado, C; Schumacher, R A; Seder, E; Sharabian, Y G; Simonyan, A; Skorodumina, Iu; Smith, G D; Sparveris, N; Stankovic, Ivana; Stepanyan, S; Strakovsky, I I; Strauch, S; Sytnik, V; Taiuti, M; Tian, Ye; Torayev, B; Ungaro, M; Voskanyan, H; Voutier, E; Walford, N K; Watts, D P; Wei, X; Weinstein, L B; Wood, M H; Zachariou, N; Zana, L; Zhang, J; Zhao, Z W; Zonta, I

    2016-01-01

    Beam-target double spin asymmetries and target single-spin asymmetries in exclusive $\\pi^+$ and $\\pi^-$ electroproduction were obtained from scattering of 1.6 to 5.7 GeV longitudinally polarized electrons from longitudinally polarized protons (for $\\pi^+$) and deuterons (for $\\pi^-$) using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. The kinematic range covered is $1.11.5$ GeV. Very large target-spin asymmetries are observed for $W>1.6$ GeV. When combined with cross section measurements, the present results will provide powerful constraints on nucleon resonance amplitudes at moderate and large values of $Q^2$, for resonances with masses as high as 2.3 GeV.

  13. Melt-spun Al70-XSi30MnX (X=0,3,5,7,10) anode in lithium-ion batteries

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Al70-XSi30MnX (X=0, 3, 5, 7, 10, mol%) ribbons were prepared by melt spinning. A supersaturated solid solution of Si and Mn in fcc Al and some microstructures consisting of nano grains were obtained. Some alloys with nano-sized grains exhibited high discharge capacities and favorable cycle properties. The capacity of more than 400 mAh/g could be obtained in melt-spun Al67Si30Mn3 alloy after 20 cycles and more than 300 mAh/g after 40 cycles. Li/Si and Li/Al compounds in the anodes of pure Al and pure Si were not detected in Al-Si-Mn alloys inserted by Li. It is considered that the formation of the supersaturated solid solution and refinement of microstructures have prevented the alloys from the forming the compounds with superfluous Li. As a result, the electrochemical properties have been improved.

  14. Electro-Organic Synthesis Of 2-Amino-9(4-Chlorophenyl-5,7,8,9- Tetra Hydro-6H Benzo [7] Annulen-6-One in Acidic Medium

    Directory of Open Access Journals (Sweden)

    HEMLATA SHARMA

    2011-06-01

    Full Text Available The electro reduction of 5-(2-chlorophenyl-1, 3- dihydro-7-2H-1, 4-benzodiazepin-2-one (clonazepam has been studied by cyclic voltammetry at glassy carbon electrodes under the acidic conditions which indicate the reducible behavior of the drug. Electro-reduction of clonazepam has also been studied by the Galvanstatic technique at copper and amalgamated forms of copper and lead electrodes under acidic conditions. The reduction product was isolated and characterized by TLC, usual laboratory qualitative tests and IR, NMR spectral analysis. Effect of different parameters like current density, temperature, depolarizer concentration and nature of cathode material on yield percentage and current efficiency has been investigated. Number of electrons have also been calculated to confirm the isolated product, which is 2-amino-9- (4-chlorophenyl-5,7,8,9-tetrahydro-6Hbenzo[ 7]annulen-6-one.

  15. Tetra­kis(5,7-dimethyl­quinolin-8-olato-κ2 N,O)zirconium(IV) dimethyl­form­amide disolvate

    OpenAIRE

    Steyn, Maryke; Visser, Hendrik G.; Roodt, Andreas

    2012-01-01

    In the title compound, [Zr(C11H10NO)4]·2C3H7NO, the ZrIV ion is coordinated by four bidentate 5,7-dimethylquinolin-8-olate ligands in a slightly distorted square-anti­prismatic coordination environment. The asymmetric unit also contains two N,N′-dimethyl­formamide (DMF) solvent mol­ecules. In the crystal, a weak C—H⋯O hydrogen bond links the complex mol­ecule to a solvent mol­ecule and weak π–π stacking inter­actions [centroid–centroid distance = 3.671 (3) Å] also occur. One of the DMF solven...

  16. Tetra-kis(5,7-dimethyl-quinolin-8-olato-κ(2)N,O)zirconium(IV) dimethyl-form-amide disolvate.

    Science.gov (United States)

    Steyn, Maryke; Visser, Hendrik G; Roodt, Andreas

    2012-11-01

    In the title compound, [Zr(C(11)H(10)NO)(4)]·2C(3)H(7)NO, the Zr(IV) ion is coordinated by four bidentate 5,7-dimethylquinolin-8-olate ligands in a slightly distorted square-anti-prismatic coordination environment. The asymmetric unit also contains two N,N'-dimethyl-formamide (DMF) solvent mol-ecules. In the crystal, a weak C-H⋯O hydrogen bond links the complex mol-ecule to a solvent mol-ecule and weak π-π stacking inter-actions [centroid-centroid distance = 3.671 (3) Å] also occur. One of the DMF solvent mol-ecules was refined as disordered over three sets of sites, with refined occupancies in the ratio of 0.391 (9):0.342 (10):0.267 (7).

  17. Unsaturated C3,5,7,9-Monocarboxylic Acids by Aqueous, One-Pot Carbon Fixation: Possible Relevance for the Origin of Life.

    Science.gov (United States)

    Scheidler, Christopher; Sobotta, Jessica; Eisenreich, Wolfgang; Wächtershäuser, Günter; Huber, Claudia

    2016-06-10

    All scientific approaches to the origin of life share a common problem: a chemical path to lipids as main constituents of extant cellular enclosures. Here we show by isotope-controlled experiments that unsaturated C3,5,7,9-monocarboxylic acids form by one-pot reaction of acetylene (C2H2) and carbon monoxide (CO) in contact with nickel sulfide (NiS) in hot aqueous medium. The primary products are toto-olefinic monocarboxylic acids with CO-derived COOH groups undergoing subsequent stepwise hydrogenation with CO as reductant. In the resulting unsaturated monocarboxylic acids the double bonds are mainly centrally located with mainly trans-configuration. The reaction conditions are compatible with an origin of life in volcanic-hydrothermal sub-seafloor flow ducts.

  18. Beyond-brand effect of television (TV) food advertisements/commercials on caloric intake and food choice of 5-7-year-old children.

    Science.gov (United States)

    Halford, Jason C G; Boyland, Emma J; Hughes, Georgina; Oliveira, Lorraine P; Dovey, Terence M

    2007-07-01

    Food advert exposure has been shown to influence calorie intake and food choice in 9-11 year olds. However, little is known about the effect of food advertisements on feeding behaviour in younger children. Therefore, we conducted a study with 93 children aged 5-7 years, 28 of whom were over weight or obese. The children were exposed to 10 non-food adverts and 10 food adverts in a repeated measures design. Their consumption of sweet and savoury, high and low fat snack foods, and fruit were measured following both sessions. Food advert exposure produced a significant increase in total food intake in young children. The collection of recognition data was incomplete. These data replicate previous findings in that exposure to food adverts increases food intake in all children, but recognition of food adverts is related to body mass index (BMI). Beyond their effects on brand choice, exposure to food advertisements (commercials) promotes over-consumption in younger children.

  19. The Observations of the Supernova Remnant G65.2+5.7 in the Emission Lines of OIII NII and SII

    Science.gov (United States)

    Sitnik, T. G.; Klementeva, A. Y.; Toropova, M. S.

    1983-06-01

    Isophote charts in the [O III], [N II], and [S II] lines of the bright filament S 91 lying to the SE of the supernova remnant G 65.2+5.7 are constructed. The stratification of the emission regions in these lines is discovered. [O III] regions lie closer to the external ridge of the supernova remnant than the regions which emit the [N II] and [S II] lines. This displacement is explained as the observed cut of the radiative loss wave behind the shock front. The visible structure of [N II] and [S II] filaments is perhaps connected with radiative loss instabilities. The small (as compared to the [N II] lines) width of the [O III] filaments is explained by a greater value of the radiative losses in the [O III] lines.

  20. Study on the supernova remnant G 65. 2+5. 7 in the emission lines of (Oy3), (N2) and (S2)

    Energy Technology Data Exchange (ETDEWEB)

    Sitnik, T.G.; Klement' eva, A.Yu.; Toropova, M.S. (Moskovskij Gosudarstvennyj Univ. (USSR). Gosudarstvennyj Astronomicheskij Inst. ' ' GAISh' ' )

    Isophote charts in the (O3), (N2) and (S2) lines of the bright filament S 91 lying to the SE of the supernova remnant G65.2+5.7 are constructed. The stratification of the emission regions in these lines is discovered. (O3) regions lie closer to the external ridge of the supernova remnant than the regions which emit the (N2) and (S2) lines. This displacement is explained as the observed cut of the radiative loss wave behind the shock front. Visible structure of (N2) and (S2) filaments is perhaps connected with the radiative loss instabilities. Small (as compared to the (N2) lines) width of the (O3) filaments is explained by a greater value of the radiative losses in the (O3) lines.

  1. Profile and activity of the bacterial biota of ground beef held from freshness to spoilage at 5-7 degrees C.

    Science.gov (United States)

    Jay, J M; Vilai, J P; Hughes, M E

    2003-03-15

    Four samples of fresh ground beef were stored aerobically and held at 5-7 degrees C for up to 28 days. Although one sample initially yielded 21 different genera of bacteria while two others yielded only seven, all four spoiled essentially in the same way as assessed by aerobic, psychrotrophic, and Gram-negative counts, and by extract-release volume (ERV) and pH values. Pseudomonas spp. was dominant in the spoilage of all samples. As to why this group is so consistently associated with the low-temperature aerobic spoilage of fresh meats, it is hypothesized that they possess the capacity to form a biofilm and that quorum sensing is involved in the overall biofilm forming and functioning processes.

  2. Synthesis and olfactory characterization of silicon-containing derivatives of the acyclic lily-of-the-valley odorant 5,7,7-trimethyl-4-methylideneoctanal.

    Science.gov (United States)

    Dörrich, Steffen; Mahler, Christoph; Tacke, Reinhold; Kraft, Philip

    2014-11-01

    5-Methyl-4-methylidene-6-(trimethylsilyl)hexanal (1b), a sila analog of the acyclic lily-of-the-valley odorant 5,7,7-trimethyl-4-methylideneoctanal (1a), and the Si-containing derivatives 2-6 were prepared in multistep syntheses, starting from Cl3 SiH and Cl2 SiMe2 , respectively. Compounds 1b, 2-6, and their new precursors were characterized by elemental analyses (C, H, N) and NMR spectroscopic studies ((1) H, (13) C, (15) N, and (29) Si). To gain more information about the structureodor correlation in the family of lily-of-the-valley or 'muguet' odorants, C/Si analogs 1a/1b and derivatives 2-6 were evaluated for their olfactory properties.

  3. Genome-Wide Association Study of Resistance to Soybean Cyst Nematode (Heterodera glycines HG Type 2.5.7 in Wild Soybean (Glycine soja

    Directory of Open Access Journals (Sweden)

    Hengyou Zhang

    2016-08-01

    Full Text Available Soybean cyst nematode (SCN is the most destructive soybean pest worldwide. Host plant resistance is the most environmentally friendly and cost-effective way of mitigating SCN damage to soybeans. However, overuse of the resistant soybean (Glycine max (L. Merr. cultivars from limited genetic resources has resulted in SCN race shifts in many soybean-growing areas. Thus, exploration of novel sources of SCN resistance and dissection of the genetic basis are urgently needed. In this study, we screened 235 wild soybean (Glycine soja Sieb. & Zucc. accessions to identify genotypes resistant to SCN HG Type 2.5.7 (race 5, a less investigated type but is prevalent in the southeastern US. We also dissected the genetic basis of SCN resistance using a genome-wide association study with SNPs genotyped by SoySNP50k iSelect BeadChip. In total, 43 resistant accessions (female index < 30 were identified, with ten SNPs being significantly associated with SCN HG 2.5.7 resistance in this wild species. Furthermore, four significant SNPs were localized to linked regions of the known quantitative trait locus (QTL rhg1 on chromosome 18. The other four SNPs on chromosome 18 and two SNPs on chromosome 19 are novel. Genes encoding disease resistance-related proteins with a leucine-rich region, a mitogen-activated protein kinase (MAPK on chromosome 18, and a MYB transcription factor on chromosome 19 were identified as promising candidate genes. The identified SNPs and candidate genes will benefit future marker-assisted breeding and dissection of the molecular mechanisms underlying the soybean-SCN interaction.

  4. Genome-Wide Association Study of Resistance to Soybean Cyst Nematode (Heterodera glycines) HG Type 2.5.7 in Wild Soybean (Glycine soja).

    Science.gov (United States)

    Zhang, Hengyou; Li, Chunying; Davis, Eric L; Wang, Jinshe; Griffin, Joshua D; Kofsky, Janice; Song, Bao-Hua

    2016-01-01

    Soybean cyst nematode (SCN) is the most destructive soybean pest worldwide. Host plant resistance is the most environmentally friendly and cost-effective way of mitigating SCN damage to soybeans. However, overuse of the resistant soybean [Glycine max (L.) Merr.] cultivars from limited genetic resources has resulted in SCN race shifts in many soybean-growing areas. Thus, exploration of novel sources of SCN resistance and dissection of the genetic basis are urgently needed. In this study, we screened 235 wild soybean (Glycine soja Sieb. & Zucc.) accessions to identify genotypes resistant to SCN HG Type 2.5.7 (race 5), a less investigated type but is prevalent in the southeastern US. We also dissected the genetic basis of SCN resistance using a genome-wide association study with SNPs genotyped by SoySNP50k iSelect BeadChip. In total, 43 resistant accessions (female index < 30) were identified, with 10 SNPs being significantly associated with SCN HG 2.5.7 resistance in this wild species. Furthermore, four significant SNPs were localized to linked regions of the known quantitative trait locus (QTL) rhg1 on chromosome 18. The other four SNPs on chromosome 18 and two SNPs on chromosome 19 are novel. Genes encoding disease resistance-related proteins with a leucine-rich region, a mitogen-activated protein kinase (MAPK) on chromosome 18, and a MYB transcription factor on chromosome 19 were identified as promising candidate genes. The identified SNPs and candidate genes will benefit future marker-assisted breeding and dissection of the molecular mechanisms underlying the soybean-SCN interaction.

  5. Changes in firing rate and firing pattern of midbrain dopaminergic neurons after lesioning of the dorsal raphe nucleus by 5,7-drhydroxytryptamine in adult rats

    Institute of Scientific and Technical Information of China (English)

    Wang Shuang; Liu Jian; Wang Tao; Han Lingna; Zhang Qiaojun; Li Qiang

    2008-01-01

    Objective To study the effect of serotonergic efferent projection of the dorsal rophe nucleus (DRN) on the activity of substantia nigro pars compacta (SNc) and ventral tegmenta area (VTA) dopaminergic neurons after lesioning of the DRN by the neurotoxin 5,7-drhydroxytryptamine (5,7-DHT) in rot. Methods The changes in the firing rote and firing pattern of SNc and VTA dopaminergic neurons were observed with extrocellular recording in control and the lesioned rats. Results The results showed that the mean firing rotes of the fast-firing dopaminergic neurons of the SNc in control and the lesioned rots were (5.34±0. 13 ) Hz (n = 23 ) and ( 7.13±0. 49 ) Hz (n=37), respectively. The mean firing rote of the fast-firing dopaminergic neurons of the SNc in the lesioned rats was significantly increased when compared to that of control rots (P<0.01), while the mean firing rote of the slow-firing dopaminergic neurons of the SNc did not change. The mean firing rotes of dopaminergic neurons of the VTA in control and the lesioned rots were (5.27±0. 38)Hz (n=35) and (3.6±0.2)Hz (n=52), respectively. Lesioning of the DRN induced a significant decrease in the mean firing rote of dopaminergic neurons of the VTA. The firing pattern of SNc and VTA dopaminergic neurons changed towards a more bursting or irrgular firing after the lesioning. Conlusion These data suggest that the serotonergic efferent projections of the DRN significantly affect the activity of SNe and VTA dopaminergic neurons.

  6. Microstructure and tensile creep resistance of Mg-5.5%Zn-(0.7%, 1.5%, 3.5%, 7.5%)Y alloys

    Institute of Scientific and Technical Information of China (English)

    陈刚; 张艳斌; 夏伟军; 陈鼎

    2015-01-01

    The tensile creep resistance of Mg-5.5%Zn-(0.7%, 1.5%, 3.5%, 7.5%)Y (mass fraction, %) gravity-casting alloys was investigated systematically. The corresponding physical models were established for analyzing the microstructure evolution and creep mechanism. The results show that four second phases are found in Mg-5.5%Zn-(0.7%, 1.5%, 3.5%, 7.5%)Y alloys, including Mg3ZnY, Mg3Zn6Y, Mg3Zn3Y2 and Mg7Zn3, where the rare earth rich phase (Mg3ZnY, Mg3Zn6Y, Mg3Zn3Y2) with high melting point can more effectively improve the creep resistance properties of alloys than Mg7Zn3. With the increasing of Y content, the creep resistance of alloys is improved correspondingly. The alloys with (1.5%, 3.5%)Y addition exhibit high creep resistance at temperatures from 175 °C to 200 °C and load from 55 MPa to 70 MPa. The 7.5%Y added alloy presents excellent creep resistance even at 275 °C and 55 MPa. The second phase which shows discontinuous distribution at the grain boundary of (0.7%, 1.5%, 3.5%)Y added alloys has preferred orientation and clogs in triple junctions of grain boundary. Simultaneously, the arrangement of second phase particles along tensile direction and the formation of denuded zones are observed during the creep process. Moreover, the crack initiates in these areas and propagates along grain boundary. Compared with discontinuous second phase, the continuous skeleton-like second phase of 7.5%Y added alloy at grain boundary has a better effect on improving the creep resistance properties of alloys.

  7. Microstructure and tensile creep resistance of Mg-5.5%Zn-(0.7%, 1.5%, 3.5%, 7.5%)Y alloys

    Institute of Scientific and Technical Information of China (English)

    陈刚; 张艳斌; 夏伟军; 陈鼎

    2015-01-01

    The tensile creep resistance of Mg-5.5%Zn-(0.7%, 1.5%, 3.5%, 7.5%)Y(mass fraction, %) gravity-casting alloys was investigated systematically. The corresponding physical models were established for analyzing the microstructure evolution and creep mechanism. The results show that four second phases are found in Mg-5.5%Zn-(0.7%, 1.5%, 3.5%, 7.5%)Y alloys, including Mg3 Zn Y, Mg3Zn6 Y, Mg3Zn3Y2 and Mg7Zn3, where the rare earth rich phase(Mg3Zn Y, Mg3Zn6 Y, Mg3Zn3Y2) with high melting point can more effectively improve the creep resistance properties of alloys than Mg7Zn3. With the increasing of Y content, the creep resistance of alloys is improved correspondingly. The alloys with(1.5%, 3.5%)Y addition exhibit high creep resistance at temperatures from 175 °C to 200 °C and load from 55 MPa to 70 MPa. The 7.5%Y added alloy presents excellent creep resistance even at 275 °C and 55 MPa. The second phase which shows discontinuous distribution at the grain boundary of(0.7%, 1.5%, 3.5%)Y added alloys has preferred orientation and clogs in triple junctions of grain boundary. Simultaneously, the arrangement of second phase particles along tensile direction and the formation of denuded zones are observed during the creep process. Moreover, the crack initiates in these areas and propagates along grain boundary. Compared with discontinuous second phase, the continuous skeleton-like second phase of 7.5%Y added alloy at grain boundary has a better effect on improving the creep resistance properties of alloys.

  8. Geomagnetic signal induced by the M5.7 earthquake occurred on September 24-th, 2016, in the seismic active Vrancea zone, Romania

    Science.gov (United States)

    Stanica, Dumitru; Armand Stanica, Dragos

    2017-04-01

    In this paper, we used the geomagnetic time series collected in real time by the electromagnetic monitoring system, placed at the Geomagnetic Observatory Provita de Sus, to emphasize possible relationships between the pre-seismic anomalous behavior of the normalized function Bzn and M5.7 earthquake occurrence in Vrancea seismic active zone, on September 24, 2016. It has already been demonstrated (Stanica and Stanica, 2012, Stanica et al., 2015) that for a 2D geoelectric structure, in pre-seismic conditions, the normalized function Bzn has significant changes in magnitudes due to the electrical conductivity changes, possibly associated with the earthquake-induced rupture-processes and high-pressure fluid flow through the faulting systems developed inside the Vrancea seismogenic volume and along the Carpathian electrical conductivity anomaly. In this circumstances, the daily mean distributions of the Bzn = Bz/Bperp (where Bz is vertical component of the geomagnetic field; Bperp is geomagnetic component perpendicular to the geoelectric strike) and its standard deviation (SD) are performed in the ULF frequency range 0.001Hz to 0.0083Hz by using both the FFT band-pass filter analysis and statistical analysis based on a standardized random variable equation. After analyzing the pre-seismic anomalous intervals, a pre-seismic geomagnetic signal greater than 5 SD was identified on September 22, 2016, what means a lead time of 2 days before the M5.7 earthquake occurred on September 24, emphasized in real time on the web site (www.geodin.ro). The final conclusion is that the proposed geomagnetic methodology might be used to provide suitable information for the extreme seismic hazard assessment and risk mitigation. References: Dumitru Stanica and Dragos Armand Stanica, Earthquakes precursors, in "Earthquake Research and Analysis-Statistical Studies, Observations and Planning" Book 5, edited by: Dr. Sebastiano D'Amico, ISBN 978-953-51-0134-5, InTech open access publisher

  9. Radio and millimeter properties of $z \\sim 5.7$ Ly$\\alpha$ emitters in the COSMOS field: limits on radio AGN, submm galaxies, and dust obscuration

    CERN Document Server

    Carilli, C L; Wang, R; Schinnerer, E; Taniguchi, Y; Smolcic, V; Bertoldi, F; Ajiki, M; Nagao, T; Sasaki, S S; Shioya, Y; Aguirre, J E; Blain, A W; Scoville, N Z; Sanders, D B

    2006-01-01

    We present observations at 1.4 and 250 GHz of the $z\\sim 5.7$ Ly$\\alpha$ emitters (LAE) in the COSMOS field found by Murayama et al.. At 1.4 GHz there are 99 LAEs in the lower noise regions of the radio field. We do not detect any individual source down to 3$\\sigma$ limits of $\\sim 30\\mu$Jy beam$^{-1}$ at 1.4 GHz, nor do we detect a source in a stacking analysis, to a 2$\\sigma$ limit of $2.5\\mu$Jy beam$^{-1}$. At 250 GHz we do not detect any of the 10 LAEs that are located within the central regions of the COSMOS field covered by MAMBO ($20' \\times 20'$) to a typical 2$\\sigma$ limit of $S_{250} 6\\times 10^{24}$ W Hz$^{-1}$ in the LAE sample. The radio and millimeter observations also rule out any highly obscured, extreme starbursts in the sample, ie. any galaxies with massive star formation rates $> 1500$ M$_\\odot$ year$^{-1}$ in the full sample (based on the radio data), or 500 M$_\\odot$ year$^{-1}$ for the 10% of the LAE sample that fall in the central MAMBO field. The stacking analysis implies an upper li...

  10. Evaluation of fractions and 5,7-dihydroxy-4',6-dimethoxy-flavone fromClerodendrum phlomidis Linn. F. against Helicoverpa armigera Hub.

    Directory of Open Access Journals (Sweden)

    Veeramuthu Duraipandiyan

    2015-04-01

    Full Text Available Twelve fractions from chloroform extract of Clerodendrum phlomidis and 5,7-dihydroxy- 4',6-dimethoxy-flavone (pectolinaringenin were evaluated against Helicoverpa armigera. Maximum antifeedant (89.41%, larvicidal (83.77% and ovicidal (69.25% activities were observed in fraction 5. The least LC50 value for antifeedant (178.09 ppm and larvicidal (198.23 ppm were observed in fraction 5. No adult emergence was recorded in fractions 4-6 at 1000 ppm. The oviposition deterrent activity was 100% in fraction 5 at all the concentrations. Pectolinaringenin recorded maximum antifeedant (74.68% and larvicidal (81.11% activities at 100 ppm; it completely prevented the adult emergence of H. armigera at 100 ppm. Maximum ovicidal activity at 100 ppm concentration was 67.95%. The oviposition deterrent activity was 100% in 100 and 50 ppm concentrations. C. phlomidis could be effectively used to develop a new formulation to control the economically important pests.

  11. Coagulation and ablation of biological soft tissue by quantum cascade laser with peak wavelength of 5.7 μm

    Directory of Open Access Journals (Sweden)

    Keisuke Hashimura

    2014-05-01

    Full Text Available Molecules such as water, proteins and lipids that are contained in biological tissue absorb mid-infrared (MIR light, which allows such light to be used in laser surgical treatment. Esters, amides and water exhibit strong absorption bands in the 5–7 μm wavelength range, but at present there are no lasers in clinical use that can emit in this range. Therefore, the present study focused on the quantum cascade laser (QCL, which is a new type of semiconductor laser that can emit at MIR wavelengths and has recently achieved high output power. A high-power QCL with a peak wavelength of 5.7 μm was evaluated for use as a laser scalpel for ablating biological soft tissue. The interaction of the laser beam with chicken breast tissue was compared to a conventional CO2 laser, based on surface and cross-sectional images. The QCL was found to have sufficient power to ablate soft tissue, and its coagulation, carbonization and ablation effects were similar to those for the CO2 laser. The QCL also induced comparable photothermal effects because it acted as a pseudo-continuous wave laser due to its low peak power. A QCL can therefore be used as an effective laser scalpel, and also offers the possibility of less invasive treatment by targeting specific absorption bands in the MIR region.

  12. Subaru high-$z$ exploration of low-luminosity quasars (SHELLQs). I. Discovery of 15 quasars and bright galaxies at $5.7 < z < 6.9$

    CERN Document Server

    Matsuoka, Yoshiki; Kashikawa, Nobunari; Iwasawa, Kazushi; Strauss, Michael A; Nagao, Tohru; Imanishi, Masatoshi; Niida, Mana; Toba, Yoshiki; Akiyama, Masayuki; Asami, Naoko; Bosch, James; Foucaud, Sébastien; Furusawa, Hisanori; Goto, Tomotsugu; Gunn, James E; Harikane, Yuichi; Ikeda, Hiroyuki; Kawaguchi, Toshihiro; Kikuta, Satoshi; Komiyama, Yutaka; Lupton, Robert H; Minezaki, Takeo; Miyazaki, Satoshi; Morokuma, Tomoki; Murayama, Hitoshi; Nishizawa, Atsushi J; Ono, Yoshiaki; Ouchi, Masami; Price, Paul A; Sameshima, Hiroaki; Silverman, John D; Sugiyama, Naoshi; Tait, Philip J; Takada, Masahiro; Takata, Tadafumi; Tanaka, Masayuki; Tang, Ji-Jia; Utsumi, Yousuke

    2016-01-01

    We report the discovery of 15 quasars and bright galaxies at $5.7 < z < 6.9$. This is the initial result from the Subaru High-$z$ Exploration of Low-Luminosity Quasars (SHELLQs) project, which exploits the exquisite multi-band imaging data produced by the Subaru Hyper Suprime-Cam (HSC) Strategic Program survey. The candidate selection is performed by combining several photometric approaches including a Bayesian probabilistic algorithm to reject stars and dwarfs. The spectroscopic identification was carried out with the Gran Telescopio Canarias and the Subaru Telescope for the first 80 deg$^2$ of the survey footprint. The success rate of our photometric selection is quite high, approaching 100 % at the brighter magnitudes ($z_{\\rm AB} < 23.5$ mag). Our selection also recovered all the known high-$z$ quasars on the HSC images. Among the 15 discovered objects, six are likely quasars, while the other six with interstellar absorption lines and in some cases narrow emission lines are likely bright Lyman-br...

  13. People maintain their sun exposure behaviour in a 5-7-year follow-up study using personal electronic UVR dosimeters.

    Science.gov (United States)

    Thieden, Elisabeth; Heydenreich, Jakob; Philipsen, Peter A; Wulf, Hans Christian

    2013-01-01

    The main purpose of this study was to investigate whether people change their sun behaviour over a period of 7 years. Thus 32 volunteers, who had all participated in earlier sun exposure studies in 1999-2001, were enrolled in a follow-up study in 2006. They were selected to represent a previous low, medium and high UVR exposure. They participated for mean 121 days (range 65-157 days) wearing a personal, electronic wrist-borne UVR dosimeter and completed sun exposure diaries. No statistically significant differences were seen from year to year in the estimated annual UVR dose, mean UVR dose per day or mean percentage of ambient UVR. However, there was a person effect showing that participants maintained a high or low UVR dose lifestyle over the years. In 2006 the 32 participants received an estimated annual mean UVR dose of 221 SED and a median dose of 154 SED (range 25-1337 SED), while they received a mean for the previous participation years (1999-2001) of 236 SED (median 153 SED, range 24-980 SED). The estimated annual UVR dose for each of the previous sun years and the estimated annual dose for 2006 correlated significantly (R(2) = 0.51; p < 0.0001). Sun risk behaviour, expressed as days sunbathing, did not change either. The participants thus seem to have maintained their sun exposure behaviour over a 5-7-year period.

  14. Preliminary Study on the Dynamic Variations of the Surface Thermal Flux before and after the Ms5.7 Earthquake of 2005 in Jiujiang City, Jiangxi Province

    Institute of Scientific and Technical Information of China (English)

    Chen Meihua; Deng Zhihui; Wang Yu; Liao Zhihui; Zu Jinhua

    2008-01-01

    The temporal and spatial variations of surface latent heat flux (SLHF) and diagnostic air temperature at 2m before and after the Ms5.7 earthquake occurring on November 26, 2005 in the area between Ruichang City and Jiujiang City, Jiangxi Province are summarized in this paper. It is found that before the earthquake significant SLHF anomalies and air temperature anomalies occurred in the epicentral area and its vicinity. The air temperature anomalies appeared from the 2nd to the 13th of November, 2005 and were concentrated at the epicentral area and in its southern part. Then two days later, that is, from the 4th to the 15th of November 2005, significant SLHF anomalies occurred in the epicentral area and to its northern area where many lakes are distributed along the active faults. During the anomalous period, the SLHF and air temperature at 2m exceeded the sum of average daily value over 26 years and 1.5 times of its mean square deviation. Both anomalies had maintained for 12 days with a peculiar distribution related to the tectonic active zone. It is considered that both of air temperature anomalies and SLHF anomalies are correlated to the movement of thermal flux from underground prior to earthquake. SLHF anomalies occurred over wide regions covered with abundant water, whereas air temperature anomalies occurred over land.

  15. Including land cover change in analysis of greenness trends using all available Landsat 5, 7, and 8 images: A case study from Guangzhou, China (2000–2014)

    Science.gov (United States)

    Zhu, Zhe; Fu, Yingchun; Woodcock, Curtis; Olofsson, Pontus; Vogelmann, James; Holden, Christopher; Wang, Min; Dai, Shu; Yu, Yang

    2016-01-01

    Remote sensing has proven a useful way of evaluating long-term trends in vegetation “greenness” through the use of vegetation indices like Normalized Differences Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI). In particular, analyses of greenness trends have been performed for large areas (continents, for example) in an attempt to understand vegetation response to climate. These studies have been most often used coarse resolution sensors like Moderate Resolution Image Spectroradiometer (MODIS) and Advanced Very High Resolution Radiometer (AVHRR). However, trends in greenness are also important at more local scales, particularly in and around cities as vegetation offers a variety of valuable ecosystem services ranging from minimizing air pollution to mitigating urban heat island effects. To explore the ability to monitor greenness trends in and around cities, this paper presents a new way for analyzing greenness trends based on all available Landsat 5, 7, and 8 images and applies it to Guangzhou, China. This method is capable of including the effects of land cover change in the evaluation of greenness trends by separating the effects of abrupt and gradual changes, and providing information on the timing of greenness trends.

  16. A replication of the 5-7 day dream-lag effect with comparison of dreams to future events as control for baseline matching.

    Science.gov (United States)

    Blagrove, Mark; Henley-Einion, Josie; Barnett, Amanda; Edwards, Darren; Heidi Seage, C

    2011-06-01

    The dream-lag effect refers to there being, after the frequent incorporation of memory elements from the previous day into dreams (the day-residue), a lower incorporation of memory elements from 2 to 4 days before the dream, but then an increased incorporation of memory elements from 5 to 7 days before the dream. Participants (n=8, all female) kept a daily diary and a dream diary for 14 days and then rated the level of matching between every dream report and every daily diary record. Baseline matching was assessed by comparing all dream reports to all diary records for days that occurred after the dream. A significant dream-lag effect for the 5-7 day period, compared to baseline and compared to the 2-4 day period, was found. This may indicate a memory processing function for sleep, which the dream content may reflect. Participants' and three independent judges' mean ratings also confirmed a significant day-residue effect. Copyright © 2010 Elsevier Inc. All rights reserved.

  17. Imaging of the solar atmosphere by the Siberian Solar Radio Telescope at 5.7 GHz with an enhanced dynamic range

    CERN Document Server

    Kochanov, Alexey; Prosovetsky, Dmitry; Rudenko, George; Grechnev, Victor

    2013-01-01

    The Siberian Solar Radio Telescope (SSRT) is a solar-dedicated directly-imaging interferometer observing the Sun at 5.7 GHz. The SSRT operates in the two-dimensional mode since 1996. The imaging principle of the SSRT restricts its opportunities in observations of very bright flare sources, while it is possible to use `dirty' images in studies of low brightness features, which do not overlap with side lobes from bright sources. The interactive CLEAN technique routinely used for the SSRT data provides imaging of active regions but consumes much time and efforts and does not reveal low-brightness features below the CLEAN threshold. The newly developed technique combines the CLEAN routine with the directly imaging capability of the SSRT and provides clean images with an enhanced dynamic range automatically. These elaborations considerably extend the range of tasks, which can be solved with the SSRT. We show some examples of the present opportunities of the SSRT and compare its data with the images produced by the...

  18. Synthesis and Crystal Structure of Dicyanamide(5,7,7,12,14,14-Hexamethyl-1,4,8,11-tetraazacyclotetradecane) Copper(II) Percholatehydrate

    Institute of Scientific and Technical Information of China (English)

    李宝宗; 王寿武; 李宝龙; 张勇

    2004-01-01

    The copper(II) complex [Cu(teta)N(CN)2](ClO4)·H2O (teta = 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane) has been synthesized and the crystal structure was determined by single-crystal X-ray diffraction.Crystal data: C18H38ClCuN7O5,monoclinic,space group P21/n,a = 8.796(3),b = 11.885(4),c = 23.054(9)(A),β = 97.540(4)o,V = 2389.3(15)(A)3,Mr = 531.54,Z = 4,Dc = 1.478 g/cm3,F(000) = 1124,μ = 1.070 mm-1,the final R = 0.0566 and Wr = 0.1162 for 4749 observed reflections (I > 2б(I)).The center copper ion is coordinated by five nitrogen atoms in a square pyramidal geometry,with four from the macrocyclic ligand teta and the other one from a nitrile nitrogen atom of dicyanamide which is coordinated to the metal atoms as uni-dentate manner via nitrile nitrogen atom.

  19. Protonated 14-membered 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetrazacyclotetradeca-7,14-diene Salts and Their Biological Activity

    Directory of Open Access Journals (Sweden)

    Siti Fairus M. Yusoff

    2013-01-01

    Full Text Available The 14-membered heterocyclic 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetrazacyclotetradeca-7,14-diene, [(Me6[14]N4diene], salts with structural formula of [(Me6[14]N4diene]Br2(H2O2, [(Me6[14]N4dieneCl2](H2O3, Me6[14]N4diene.(ClO42, Me6[14]N4diene.(PF62¬  and   Me6[14]N4diene.(NO32   have been  synthesized without the necessity of a template. The salts were characterized by FTIR, and NMR spectroscopic techniques. X-ray study showed that the macrocyclic cation consists of a pair of protonated amines and azomethine nitrogen atoms located diagonally and opposite to each other. Only the macrocylic bromide and perchlorate salts showed activity against gram-positive E. faecalis and gram-negative E. Coli.

  20. Membrane domain specificity in the spatial distribution of aquaporins 5, 7, 9, and 11 in efferent ducts and epididymis of rats.

    Science.gov (United States)

    Hermo, Louis; Schellenberg, Morgan; Liu, Lauren Ye; Dayanandan, Bama; Zhang, Tong; Mandato, Craig A; Smith, Charles E

    2008-12-01

    Water content within the epididymis of the male reproductive system is stringently regulated to promote sperm maturation. Several members of the aquaporin (AQP) family of water channel-forming integral membrane proteins have been identified in epididymal cells, but expression profiling for this epithelium is presently incomplete, and no AQP isoform has yet been identified on basolateral plasma membranes of these cells. In this study, we explored AQP expression by RT-PCR and light microscopy immunolocalizations using peroxidase and wide-field fluorescence techniques. The results indicate that several AQPs are coexpressed in the epididymis including AQP 5, 7, 9, and 11. Immunolocalizations suggested complex patterns in the spatial distribution of these AQPs. In principal cells, AQP 9 and 11 were present mainly on microvilli, whereas AQP 7 was localized primarily to lateral and then to basal plasma membranes in a region-specific manner. AQP 5 was also expressed regionally but was associated with membranes of endosomes. Additionally, AQPs were expressed by some but not all basal (AQP 7 and 11), clear (AQP 7 and 9), and halo (AQP 7 and 11) cells. These findings indicate unique associations of AQPs with specific membrane domains in a cell type- and region-specific manner within the epididymis of adult animals.

  1. 早期神经移位治疗臂丛颈5-7根性损伤的长期疗效观察%Long-term efficacy of nerves transfer early for treating the C5-7 root injury of the brachial plexus

    Institute of Scientific and Technical Information of China (English)

    徐房添; 徐芳; 赖光松; 高辉; 姬广林; 杨千绮

    2015-01-01

    Objective To evaluate the long-term results of reconstructing shoulder abduction by transfering nerve early for treating the C5-7 root injury of brachial plexus. Methods Eleven patients with the complete C5-7 root injury were surgically treated to reconstruct shoulder abduction function with the double nerve transfer. The accessory nerve was transferred to the suprascapular nerve,the nerve branch to the long head of triceps muscle from radial nerve to the deltoid branch of axillary nerve. The electrophysiological technique was carried out before and during operation in order to improve the accuracy and feasibility of procedures. Results All patients were followed up from 37months to 96 months (67.8 months on average). The shoulder function was rated as excellent in 9 cases,as good in 7 cases and the recovery results of shoulder abduction,superduction and external ro-tation are satisfied. There was the regenerative potential in deltoid and the supraspinatus and the infraspinatus of 6 patients 3 months after operation. Conclusion The double nerve transfer in reconstructing shoulder abduction is more effective and reason-able after diagnosed as the C5-7 root injury,Which has improved the efficiency of shoulder abduction reconstruction.%目的 分析早期移位桡神经三头肌肌支及副神经治疗臂丛颈5-7根性损伤中重建肩外展功能的长期疗效.方法 臂丛颈5-7根性损伤11例,确诊后早期即施行神经移位术:桡神经肱三头肌长头支移位至腋神经的三角肌支、副神经移位至肩胛上神经,施行双重移位,同时重建冈上下肌与三角肌的功能.术中运用电生理技术,增加手术的准确性和合理性.并进行了平均67.8个月的长期随访,按结果分析疗效.结果 优9例,良2例,肩外展功能恢复满意.6例在术后约3个月冈上下肌、三角肌电生理检查即可检出再生电位.结论 臂丛颈5-7根性损伤确诊后,早期行副神经及肱三头肌肌支双重移位是重建

  2. Calculation of the energy balance and economic efficiency for a hired multiple dwelling unit in a stock Holbeinstrasse 3-5-7, Ruesselsheim. Final report; Energiebilanz- und Wirtschaftlichkeitsberechnungen fuer ein vermietetes Mehrfamilienhaus im Bestand Holbeinstrasse 3-5-7, Ruesselsheim. Endbericht

    Energy Technology Data Exchange (ETDEWEB)

    Enseling, Andreas; Hinz, Eberhard

    2009-01-16

    The authors of the contribution under consideration calculate the energy balance and economy for a rented multi-family house in the stock Holbein Street 3-5-7, Ruesselsheim (Federal Republic of Germany). The measured values only permit a rough estimation of the energy efficiency of the building and its heat supply system. The building with its thermal characteristics and the concept of power supply are not co-ordinated optimally. The heat requirement of the building is too high in order to be covered with renewable energy. Regarding the high capital costs an optimization potential exists during the heat supply.

  3. 基于FDTD方法的2.4/5.2/5.7 GHz穿戴式躯域传感器网络体表信道特征分析%On-body propagation characterization based on FDTD method for 2.4/5.2/5.7 GHz wearable body sensor networks

    Institute of Scientific and Technical Information of China (English)

    鲍淑娣; 沈连丰; 张元亭

    2007-01-01

    The on-body path loss and time delay of radio propagation in 2.4/5.2/5.7 GHz wearable body sensor networks (W-BSN) are studied using Remcom XFDTD, a simulation tool based on the finite-difference timedomain method. The simulation is performed in the environment of free space with a simplified threedimensional human body model. Results show that the path loss at a higher radio frequency is significantly smaller. Given that the transmitter and the receiver are located on the body trunk, the path loss relevant to the proposed minimum equivalent surface distance follows a log-fitting parametric model, and the path loss exponents are 4.7, 4.1 and 4.0 at frequencies of 2.4, 5.2, 5.7 GHz, respectively. On the other hand, the firstarrival delays are less than 2 ns at all receivers, and the maximum time delay spread is about 10 ns. As suggested by the maximum time delay spread, transmission rates of W-BSN must be less than 108 symbol/s to avoid intersymbol interference from multiple-path delay.%应用基于时域有限差分法(FDTD)的XFDTD仿真工具分析研究2.4/5.2/5.7 GHz穿戴式躯域传感器网络(W-BsN)的体表路径损耗和时延特性.仿真环境为置于自由空间中的简化三维人体模型.分析结果表明,当工作频率较高时,路径损耗相对较小;当发送点和接收点都置于主躯干时,路径损耗与最小等效体表距离遵循对数拟合模型,并且2.4,5.2,5.7 GHz下的衰减指数分别为4.7,4.1和4.0.另一方面,各接收点的首径延迟约小于2 ns,而最大时延扩展为10 ns.为避免多径延迟引起的码间干扰,建议W-BSN的传输速率应小于108符号/s.

  4. Women's higher likelihood of disability pension: the role of health, family and work. A 5-7 years follow-up of the Hordaland Health Study.

    Science.gov (United States)

    Haukenes, Inger; Gjesdal, Sturla; Rortveit, Guri; Riise, Trond; Maeland, John Gunnar

    2012-08-31

    Women's higher risk of disability pension compared with men is found in countries with high female work participation and universal welfare schemes. The aim of the study was to examine the extent to which self-perceived health, family situation and work factors explain women's higher risk of disability pension. We also explored how these factors influenced the gender difference across educational strata. The population-based Hordaland Health Study (HUSK) was conducted in 1997-99 and included inhabitants born in 1953-57 in Hordaland County, Norway. The current study included 5,959 men and 6,306 women in paid work with valid information on education and self-perceived health. Follow-up data on disability pension, for a period of 5-7 years, was obtained by linking the health survey to a national registry of disability pension. Cox regression analyses were employed. During the follow-up period 99 (1.7%) men and 230 (3.6%) women were awarded disability pension, giving a twofold risk of disability pension for women compared with men. Except for a moderate impact of self-perceived health, adjustment for family situation and work factors did not influence the gender difference in risk. Repeating the analyses in strata of education, the gender difference in risk of disability pension among the highly educated was fully explained by self-perceived health and work factors. In the lower strata of education there remained a substantial unexplained gender difference in risk. In a Norwegian cohort of middle-aged men and women, self-perceived health, family situation and work factors could not explain women's higher likelihood of disability pension. However, analyses stratified by educational level indicate that mechanisms behind the gender gap in disability pension differ by educational levels. Recognizing the heterogeneity within gender may contribute to a deeper understanding of women's higher risk of disability pension.

  5. Fe60CoxZr10Mo5W2B23-x(x=1,3,5,7,9)块状金属玻璃的非晶形成能力%Glass forming ability of Fe60 Cox Zr10Mo5 W2B23-x (x = 1,3,5,7,9) bulk metallic glasses

    Institute of Scientific and Technical Information of China (English)

    刘冬艳; 张海峰; 邓胜涛; 胡壮麒

    2005-01-01

    The bulk Fe60CoxZr10Mo5W2B23-x (x= 1, 3, 5, 7, 9) amorphous rods with diameters of1.5 mm were successfully prepared by copper mold casting method with the low purity raw materials.The amorphous and crystalline states, and thermal parameters, such as the glass transition temperature (Tg), the initial crystallization temperature (Tx), the supercooled liquid region (ΔTx = TxTg), the reduced glass transition temperature Trg (Tg/Tm, Tm: the onset temperature of melting of the alloy, and Tg/T1, T1 : the finished temperature of melting of the alloy) were investigated by X-ray diffractometry (XRD) and differential scanning calorimetry (DSC) analysis. Glass forming ability of Fe60CoxZr10Mo5W2B23-x (x=1, 3, 5, 7, 9)bulk metallic glasses has been studied. According to the results, the alloy (x=7) with the highest Trg (Tg/T1 =0. 607, Tg/T1 =0.590) value, has the strongest glass forming ability among these alloys because its composition is near eutectic composition.The wide supercooled liquid region over 72 K indicates the high thermal stability for this alloy system.This bulk metallic glass exhibits quite high strength (Hv 1020). The success of production of the Febased bulk metallic glass with industrial materials is of great significance for the future progress of basic research and practical application.

  6. A Fast Liquid Chromatography Tandem Mass Spectrometric Analysis of PETN (Pentaerythritol Tetranitrate), RDX (3,5-Trinitro-1,3,5-triazacyclohexane) and HMX (Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) in Soil, Utilizing a Simple Ultrasonic-Assisted Extraction with Minimum Solvent.

    Science.gov (United States)

    Anilanmert, Beril; Aydin, Muhammet; Apak, Resat; Avci, Gülfidan Yenel; Cengiz, Salih

    2016-01-01

    Direct analyses of explosives in soil using liquid chromatography tandem mass spectrometry (LC-MS/MS) methods are very limited in the literature and require complex procedures or relatively high amount of solvent. A simple and rapid method was developed for the determination of pentaerythritol tetranitrate (PETN), 3,5-trinitro-1,3,5-triazacyclohexane (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), which are among the explosives used in terrorist attacks. A one-step extraction method for 1.00 g soil with 2.00 mL acetonitrile, and a 8-min LC-MS/MS method was developed. The detection limits for PETN, RDX and HMX were 5.2, 8.5 and 3.4 ng/g and quantitation limits were 10.0, 24.5, 6.0 ng/g. The intermediate precisions and Horwitz Ratio's were between 4.10 - 13.26% and 0.24 - 0.98, in order. This method was applied to a model post-blast debris collected from an artificial explosion and real samples collected after a terrorist attack in Istanbul. The method is easy and fast and requires less solvent use than other methods.

  7. 5, 7, 3', 4'-tetramethoxy-flavonoid on the Cystic Fibrosis Transmembrane Conductance Regulator Activation Factor%5,7,3’,4’-四甲氧基黄酮对囊性纤维化跨膜转运调节因子的激活作用

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    囊性纤维化跨膜转运调节因子(CFTR),是一种受cAMP依赖的氯离子通道蛋白.CFTR在哺乳动物呼吸道和胃肠道粘膜等多种与分泌和吸收相关的上皮细胞内广泛表达,对上皮细胞的液体转运、盐类运输和离子浓度调节等具有重要的作用.CFTR功能障碍可能会引起诸如习惯性便秘等多种疾病.本实验利用细胞荧光淬灭方法测定了小分子黄酮类化合物5,7,3’,4’-四甲氧基黄酮对CFTR具有激活作用,为以CFTR作为分子靶标,用5,7,3’,4’-四甲氧基黄酮治疗CFTR相关疾病奠定了理论基础.

  8. An intermediate-depth tensional earthquake (MW 5.7) and its aftershocks within the Nazca slab, central Chile: A reactivated outer rise fault?

    Science.gov (United States)

    Marot, Marianne; Monfret, Tony; Pardo, Mario; Ranalli, Giorgio; Nolet, Guust

    2012-04-01

    An intermediate-depth earthquake (7 January 2003, Mw 5.7) occurred within the subducting Nazca plate at longitude 70.3°W, latitude 33.8°S and depth 113 km. Its focal mechanism shows normal faulting with a slight strike-slip component. We detected 50 aftershocks within January 2003 using a temporary seismic network installed in the zone. Their local magnitudes Ml range between 1.9 and 3.5, with the strongest events occurring around the mainshock. Their spatial distribution, including the mainshock, defines an area of ~ (35 ± 5) × (10 ± 2) km2, cutting through almost half of the slab's total thickness at an angle of ~ 60° to the slab's surface. This area agrees well with one of the mainshock nodal planes. However, the total seismic area, as defined by the aftershock distribution, is larger than the rupture area normally expected for an earthquake of moderate magnitude. We compare the orientation of the seismic plane with the outer rise fault pattern offshore central Chile and find a correlation with the strike of the seafloor spreading fabric. The seismic sequence shows similarities with other intermediate-depth cases, notably the 13 June 2005 Tarapacá earthquake in northern Chile and similar cases in the Pacific slab beneath Japan. In all these cases, the inferred reactivated fault planes probably originate from the outer rise region, in agreement with the hypothesis that intermediate-depth seismicity is linked to inherited faults. Consequently, even moderate-sized earthquakes can reactivate large areas of inherited faults within slabs at depths > 100 km. Furthermore, the occurrence of multiple other local events (Mw > 5), with similar focal mechanism and depth to the January 2003 event, appear to indicate that the slab becomes mechanically weak ~ 100 km depth. The depth extent in the slab of the reactivated pre-existing faults is likely governed by the slab's bending/unbending stress regime, i.e. the depth to the neutral plane. Dehydration embrittlement is a

  9. Characteristics of pneumonia deaths after an earthquake and tsunami: an ecological study of 5.7 million participants in 131 municipalities, Japan.

    Science.gov (United States)

    Shibata, Yosuke; Ojima, Toshiyuki; Tomata, Yasutake; Okada, Eisaku; Nakamura, Mieko; Kawado, Miyuki; Hashimoto, Shuji

    2016-02-23

    On 11 March 2011, the Great East Japan Earthquake struck off Japan. Although some studies showed that the earthquake increased the risk of pneumonia death, no study reported whether and how much a tsunami increased the risk. We examined the risk for pneumonia death after the earthquake/tsunami. This is an ecological study. Data on population and pneumonia deaths obtained from the Vital Statistics 2010 and 2012, National Census 2010 and Basic Resident Register 2010 and 2012 in Japan. About 5.7 million participants residing in Miyagi, Iwate and Fukushima Prefectures during 1 year after the disaster were targeted. All municipalities (n=131) were categorised into inland (n=93), that is, the earthquake-impacted area, and coastal types (n=38), that is, the earthquake-impacted and tsunami-impacted area. The number of pneumonia deaths per week was totalled from 12 March 2010 to 9 March 2012. The number of observed pneumonia deaths (O) and the sum of the sex and age classes in the observed population multiplied by the sex and age classes of expected pneumonia mortality (E) were calculated. Expected pneumonia mortality was the pneumonia mortality during the year before. Standardised mortality ratios (SMRs) were calculated for pneumonia deaths (O/E), adjusting for sex and age using the indirect method. SMRs were then calculated by coastal and inland municipalities. 6603 participants died of pneumonia during 1 year after the earthquake. SMRs increased significantly during the 1st-12th weeks. In the 2nd week, SMRs in coastal and inland municipalities were 2.49 (95% CI 2.02 to 7.64) and 1.48 (95% CI 1.24 to 2.61), respectively. SMRs of coastal municipalities were higher than those of inland municipalities. An earthquake increased the risk of pneumonia death and tsunamis additionally increased the risk. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  10. Realizing the cognitive potential of children 5-7 with a mathematics focus: post-test and long-term effects of a 2-year intervention.

    Science.gov (United States)

    Shayer, Michael; Adhami, Mundher

    2010-09-01

    In the context of the British Government's policy directed on improving standards in schools, this paper presents research on the effects of a programme intended to promote the cognitive development of children in the first 2 years of primary school (Y1 & 2, aged 5-7 years). The programme is based on earlier work dealing with classroom-based interventions with older children at both primary and secondary levels of schooling. The hypothesis tested is that it is possible to increase the cognitive ability of children by assisting teachers towards that aim in the context of mathematics. A corollary hypothesis is that such an increase would result in an increase in long-term school achievement. The participants were 8 teachers in one local education authority (LEA) and 10 teachers in another. Data were analysed on 275 children present at Year 1 pre-test in 2002 and at long-term Key Stage 2 post-test in 2008. Two intervention methods were employed: a Y1 set of interactive activities designed around Piagetian concrete operational schemata, and mathematics lessons in both Y1 and Y2 designed from a theory-base derived from both Piaget and Vygotsky. At post-test in 2004, the mean effect sizes for cognitive development of the children - assessed by the Piagetian test Spatial Relations - were 0.71 SD in one LEA and 0.60 SD in the other. Five classes achieved a median increase of 1.3 SD. The mean gains over pre-test in 2002 for all children in Key Stage 1 English in 2004 were 0.51 SD, and at Key Stage 2 English in 2008 - the long-term effect - were 0.36 SD, an improvement of 14 percentile points. The main hypothesis was supported by the data on cognitive development. The corollary hypothesis is supported by the gains in English. The implications of this study are that relative intelligence can be increased and is not fixed, and that children can be led into collaborating with each other to the benefit of their own thinking, and that there does exist a theory-based methodology

  11. Effect of 5,7-dimethoxychrysin on Cell Apoptosis of Cervical Cancer Hela Cells in vitro%5,7-二甲氧基白杨素对体外培养人宫颈癌HeLa细胞凋亡的影响

    Institute of Scientific and Technical Information of China (English)

    刘昵; 邹祝平; 陈忠东

    2010-01-01

    [目的]观察5,7-二甲氧基白杨素(dMChR)对体外培养人宫颈癌HeLa细胞凋亡的影响.[方法]运用 AO/EB荧光双染色法观察HeLa细胞凋亡形态;采用PI单染流式细胞术检测HeLa细胞凋亡率;运用FITC荧光标记流式细胞术分析HeLa细胞的Bcl-2,Bax蛋白的表达.[结果]dMChR能有效地诱导HeLa细胞凋亡;dMChR能下调HeLa细胞的Bcl-2蛋白表达,上调Bax蛋白表达,且呈浓度依赖性变化.[结论]dMChR具有诱导人宫颈癌HeLa细胞凋亡作用,这种作用与上调细胞Bax/ Bcl-2比值有关.

  12. Synthesis and anxiolytic activity of N-substituted cyclic imides N-[4-[(4-aryl)-1-piperazinyl]alkyl]-5,7-dioxabicyclo[2.2.2]octane-2, 3-dicarboximide.

    Science.gov (United States)

    Zawadowski, T; Kossakowski, J; Rump, S; Jakowicz, I; Płaźnik, A

    1995-01-01

    The preparation of N-substituted cyclic imides N-[4-[(4-aryl)-1-piperazinyl]alkyl]-5,7-dioxabicyclo[2.2.2]octane- 2, 3-dicarboximides by condensation of N-(3-chloropropyl)- or N-(4-chlorobutyl)imides with appropriate amine has been described. One of compounds was tested in the Vogel's test and displayed an expected activity on CNS.

  13. The mechanism of unexpected reduction of dimethyl pyridine-2,3-dicarboxylate to 1,2,3,4-tetrahydrofuro[3,4-b]-pyridin-5(7H)-one with sodium borohydride

    Institute of Scientific and Technical Information of China (English)

    Yan Bo Tang; Qing Jian Zhang; De Quan Yu

    2012-01-01

    An unexpected reduction of dimethyl pyridine-2,3-dicarboxylate to 1,2,3,4-tetrahydrofuro[3,4-b]pyridin-5(7H)-one with sodium borohydride in ethanol and tetrahydrofuran,respectively,is described,a hypothetic mechanism for the unusual reductive product is proposed.

  14. Biological dosimetry for the victim accidentally exposed to 192Ir radiation source at "5.7" accident in Nanjing%南京“5.7”192Ir源放射事故患者的生物剂量估算

    Institute of Scientific and Technical Information of China (English)

    戴宏; 刘玉龙; 王优优; 冯骏超; 赵骅; 刘青杰; 郭凯琳

    2016-01-01

    Objective To use three different methods in attempt to estimate the biological dose of the patient partially exposed to 192Ir source at " 5.7" accident in Nanjing,so as to provide dosimetric information for clinical remedy of exposed patients in the emergency of a nuclear accident.Methods Peripheral blood samples were collected on days 5 after exposure.The biological dose was estimated by the yields of dicentrics plus rings (" dic + r"),cytokinesis-block micronuclei (CBMN) assay and nucleoplasmic bridge plus FHC (NPB + FHC).The homogeneity of radiation exposure was examined by Poisson distribution of dicentrics.Results By using three different methods,the whole body equivalent dose was "dic + r" estimated to be 1.51 Gy (95% CI 1.40-1.61),1.47 Gy (95% CI 1.36-1.60) by CBMN and 1.30 Gy (95% CI 1.00-1.60) by NPB + FHC,respectively.A non-poisson distribution was also detected,suggesting partial body radiation exposure.Conclusions The estimated whole body equivalent dose ot a non-uniform radiation exposure was consistent with clinical diagnosis,suggesting that the yields of " dic + r",CBMN,as well as NPB + FHC,are efficient approaches to the estimation of biological doses.%目的 用3种方法估算南京“5.7”192Ir源放射事故患者的生物剂量,为核与辐射事故受照者的临床救治提供剂量资料.方法 受照后第5天采集患者外周血,分别进行外周血淋巴细胞染色体“双着丝粒+环”(“dic+r”)畸变分析、胞质分裂阻滞微核(CBMN)分析、核质桥(NPB+FHC)分析,并估算生物剂量.用双着丝粒畸变在细胞间的泊松分布情况检验照射的均匀性.结果 3种方法估算的该患者受到的一次全身等效剂量分别为“dic+r”畸变分析1.51 Gy (95% CI1.40~1.61),CBMN分析1.47 Gy(95% CI 1.36~1.60),NPB+ FHC分析1.30 Gy(95% CI1.00~1.60).泊松分布检验结果显示,该患者“dic+r”畸变偏离泊松分布,受到了不均匀照射.结论 外周血淋巴细胞染色体“dic

  15. Dynamic analysis on three indexes of biological dose estimation of the victim exposed to 192Ir radiation source at "5.7" accident in Nanjing%南京“5.7”192Ir放射事故患者三种生物剂量估算指标的衰变规律探讨

    Institute of Scientific and Technical Information of China (English)

    戴宏; 刘玉龙; 王优优; 冯骏超; 赵骅; 刘青杰; 郭凯琳

    2016-01-01

    目的 观察南京“5.7”192Ir放射事故患者受照后不同采血时间对生物剂量估算的影响,探讨3种生物剂量估算指标在体内的自然衰减规律.方法 事故后5、40和280 d,采集患者的外周血,分别进行外周血淋巴细胞染色体“双着丝粒+环”(“dic+r”)畸变分析、胞质分裂阻滞微核(CBMN)分析、核质桥+融合+马蹄形+环(NPB +FHC)分析.观察受照后不同时间染色体“dic+r”畸变、微核、NPB+FHC衰变情况及对生物剂量估算结果的影响.结果 与事故后5d的估算剂量相比,在40和280 d,染色体“dic+r”畸变分析估算的剂量分别下降34%和49%,CBMN的估算结果分别下降48%和79%,NPB+FHC的估算结果分别下降48%和75%.结论 本例事故患者受照后3种生物剂量估算指标在体内呈进行性下降,染色体“dic+r”/细胞的半衰期为40 d,3个指标在40 d时剂量估算结果与5d时比较,相对偏差>20%.%Objective To explore the natural attenuation pattern of three biological dose estimation indexes in vivo by investigating the effect on biological dosimetry of peripheral blood sampling at different time points from the victim partially exposed to 192Ir radiation source at " 5.7" accident in Nanjing.Methods Peripheral blood of the patient was collected on days 5,40 and 280 after exposure,respectively.The yields of dicentrics plus rings chromosomes ("dic + r"),cytokinesis-block micronuclei (CBMN) and nucleoplasmic bridge + fusion + horse shoe + circular(NPB + FHC) were analyzed.The dynamic reduction and dose estimation were both observed using the biomarkers mentioned above after exposure.Results Compared to the estimates on days 5 after exposure,the dose values estimated on days 40 and 280 decreased by 34% and 49% for " dic + r" method,48% and 79% for the CBMN assay,and 48% and 75% for NPN + FHC method,respectively.Conclusions Three biological dose estimation indexes show a progressive decrease in vivo

  16. The prevalence of SDQ-measured mental health problems at age 5-7 years and identification of predictors from birth to preschool age in a Danish birth cohort: the Copenhagen Child Cohort 2000

    DEFF Research Database (Denmark)

    Elberling, Hanne; Linneberg, Allan; Olsen, Else Marie

    2010-01-01

    version of the Strengths and Difficulties Questionnaire (SDQ) was answered by parents and pre-school teachers. Data from Danish national registers included perinatal data, socioeconomic data and data on child mental illness diagnosed at hospital in preschool age. Register data from the first year of life......The objective of the study is to investigate the prevalence, distribution and predictors of mental health problems in 5-7-year-old Danish children in the general population. This study is a 5-7-year follow-up study of a birth cohort of 6,090 children, the Copenhagen Child Cohort 2000. The extended...... risk load and environmental stress given the social and cultural context....

  17. The prevalence of SDQ-measured mental health problems at age 5-7 years and identification of predictors from birth to preschool age in a Danish birth cohort

    DEFF Research Database (Denmark)

    Elberling, Hanne; Linneberg, Allan; Olsen, Else Marie

    2010-01-01

    version of the Strengths and Difficulties Questionnaire (SDQ) was answered by parents and pre-school teachers. Data from Danish national registers included perinatal data, socioeconomic data and data on child mental illness diagnosed at hospital in preschool age. Register data from the first year of life......The objective of the study is to investigate the prevalence, distribution and predictors of mental health problems in 5-7-year-old Danish children in the general population. This study is a 5-7-year follow-up study of a birth cohort of 6,090 children, the Copenhagen Child Cohort 2000. The extended...... risk load and environmental stress given the social and cultural context....

  18. Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl-1H-pyrazolo[3,4-b]quinoline Derivatives

    Directory of Open Access Journals (Sweden)

    N. D. Jayanna

    2013-01-01

    Full Text Available Some novel 1-(5,7-dichloro-1,3-benzoxazol-2-yl-1H-pyrazolo[3,4-b]quinoline derivatives 8(a–f were synthesized by reacting 5,7-dichloro-2-hydrazino-1,3-benzoxazole 4 and substituted-2-chloro-3-quinoline carbaldehydes using p-toluenesulfonic acid (PTSA as a catalyst for the cyclisation. The target molecules have been characterized by IR, 1H NMR, 13C NMR, and mass spectral studies. The synthesized compounds were screened for biological activities, and some of the compounds have exhibited encouraging antibacterial and antioxidant activities. The compounds 8a and 8e showed potent antibacterial activity, whereas the compounds 8e and 8f act as antioxidants.

  19. Synthesis of 5,7-Dimethyl-2-(5-Substituted-l,3,4-Oxadiazole-2-yl)-Methylenethio-1,2,4-Triazolo[1,5-a]Pyrimidines as Potential Fungicides

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A series of diheterocyclic compounds containing 1,2,4-triazolo [l,5-a]pyrimidine and 1,3,4-oxadiazole were designed and synthesized starting from 2-mercapto-5,7-dimethyl-l,2,4-triazolo [ 1,5-a] pyrimidine. The structure of all compounds prepared were confirmed by H NMR spectroscopy and elemental analysis. The preliminary bioassay indicated that the title compounds displayed good fungicidal activity against Rhizoctonia solani.

  20. Role of crystalline precipitates on the mechanical properties of (Cu{sub 0.50}Zr{sub 0.50}){sub 100-x}Al{sub x} (x = 4, 5, 7) bulk metallic glasses

    Energy Technology Data Exchange (ETDEWEB)

    Castellero, A., E-mail: alberto.castellero@unito.it [Dipartimento di Chimica IFM and NIS, Universita di Torino, Via P. Giuria 9, I-10125 Torino (Italy); Baser, T.A. [Dipartimento di Chimica IFM and NIS, Universita di Torino, Via P. Giuria 9, I-10125 Torino (Italy); EMPA - Swiss Federal Laboratories for Materials Testing and Research, Duebendorf (Switzerland); Das, J. [IFW Dresden, Institut fuer Komplexe Materialien, Helmholtzstr. 20, D-01069 Dresden (Germany); Department of Metallurgical and Materials Engineering, Indian Institute of Technology, Kharagpur 721 302, West Bengal (India); Matteis, P. [DISMIC - Politecnico di Torino, Corso Duca degli Abruzzi 24, I-10129 Torino (Italy); Eckert, J. [IFW Dresden, Institut fuer Komplexe Materialien, Helmholtzstr. 20, D-01069 Dresden (Germany); TU Dresden, Institut fuer Werkstoffwissenschaft, D-01062 Dresden (Germany); Battezzati, L.; Baricco, M. [Dipartimento di Chimica IFM and NIS, Universita di Torino, Via P. Giuria 9, I-10125 Torino (Italy)

    2011-06-15

    Research highlights: > The glass formation reproducibility of (Cu{sub 0.50}Zr{sub 0.50}){sub 100-x}Al{sub x} (x = 4,5,7) was investigated. > X-ray amorphous Cu{sub 48}Zr{sub 48}Al{sub 4} samples contain up to 20% of B2-CuZr crystals. > Fracture strain scales directly with the amount of the B2-CuZr crystalline phase. > Spread in literature values of fracture strain for these alloys is likely due to the presence of undetected crystals. > Mechanical properties reliability can be improved by sample surface finishing. - Abstract: The mechanical behaviour upon compression of (Cu{sub 0.50}Zr{sub 0.50}){sub 100-x}Al{sub x} (x = 4, 5, 7) rods with 2 and 3 mm diameter was systematically studied and compared with the literature data. Fully amorphous bulk metallic glasses (x = 5, 7) show little permanent deformation and reproducible yield stress values. The remarkable fracture strain, observed for some apparently X-ray diffraction amorphous samples (x = 4), was found to be due to significant amounts (at least 20%) of the B2-CuZr crystalline phase. The effect of possible flaws on the external surface of the rods was evaluated by mechanical testing of either as cast and machined samples.

  1. 南京“5.7”192Ir源放射事故患者的神经行为及心理健康改变%Nervous behavior and mental health changes in a case exposed to 192Ir source at "5.7" accident in Nanjing

    Institute of Scientific and Technical Information of China (English)

    陈炜博; 刘玉龙; 卞华慧; 王优优; 李元; 郑旭; 包明月; 郭凯琳

    2016-01-01

    Objective To explore the changes in nervous behavior and mental health caused by radiation damage,and to provide clinical data and experience for the similar cases,based on the treatment process of the patient exposed to Iridium-192 source accident in Nanjing,Methods The changes in the mental status of the patient was observed closely in a manner of " one to one",or " several to one",gave psychological intervention and drug treatment.The psychological evaluation for the patient was carried out by using Cattell 16 personality factors test (16PF),self-rating depression scale (SDS) and self-rating anxiety scale(SAS).The cognitive function assessment was carried out by using mini-mental state scale (MMSE) and Montreal cognitive assessment (MoCA) Beijing version.Results The patient showed tension,fear,upset,etc.,in hospital,and psychological evaluation results showed that he had the emotions such as anxiety,depression and worry.The mental health was improved after a positive psychological counseling and treatment by using sertraline and olanzapine.Cognitive function assessment results showed that he had moderate-severe cognitive dysfunction for a time,which gradually returned to normal with the improvement of general condition.Conclusions Attention should be paid to the synchronization of physical therapy and psychological treatment in the process of clinical treatment of patients with radiation injury.Improvement to psychological problems is possible using reasonable intervention and treatment,and the cause of neurobehavioral changes still need further research.%目的 结合南京“5.7”192Ir源放射事故患者的救治过程,探讨辐射损伤导致的神经行为及心理健康改变.方法 采用“一对一”、“多对一”的方法密切观察并记录患者精神状态变化,给予心理干预及药物治疗;采用卡特尔16种个性因素测验(16PF)、抑郁自评量表(SDS)、焦虑自评量表(SAS)对患者进行心理测评;采用简短精神状

  2. A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity.

    Science.gov (United States)

    Szewczyk, Jerzy R; Laudeman, Chris P; Sammond, Doug M; Villeneuve, Manon; Minick, Douglas J; Grizzle, Mary K; Daniels, Alejandro J; Andrews, John L; Ignar, Diane M

    2010-03-01

    Finding small non-peptide molecules for G protein-coupled receptors (GPCR) whose endogenous ligands are peptides, is a very important task for medicinal chemists. Over the years, compounds mimicking peptide structures have been discovered, and scaffolds emulating peptide backbones have been designed. In our work on GPCR ligands, including cholecystokinin receptor-1 (CCKR-1) agonists, we have employed benzodiazepines as a core structure. Looking for ways to reduce molecular weight and possibly improve physical properties of GPCR ligands, we embarked on the search for molecules providing similar scaffolds to the benzodiazepine with lower molecular weight. One of our target core structures was 1,4-dihydro-[1,4]diazepine-5,7-dione. There was not, however, a known synthetic route to such molecules. Here we report the discovery of a simple and concise method for synthesis of 2-[6-(1H-indazol-3-ylmethyl)-5,7-dioxo-4-phenyl-4,5,6,7-tetrahydro-[1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide as an example of a compound containing the tetrahydrodiazepine-5,7-dione core. Compounds from this series were tested in numerous GPCR assays and demonstrated activity at melanocortin 1 and 4 receptors (MC1R and MC4R). Selected compounds from this series were tested in vivo in Peptide YY (PYY)-induced food intake. Compounds dosed by intracerebroventricular and oral routes reduced PYY-induced food intake and this effect was reversed by the cyclic peptide MC4R antagonist SHU9119.

  3. Synthesis and X-ray Crystal Structure of Meso-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-1,8-di-(1-methylnaphthalene

    Directory of Open Access Journals (Sweden)

    Dean R. Hutchings

    2003-02-01

    Full Text Available The pendant-arm macrocycle, meso-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-1,8-di-(1-methylnaphthalene has been synthesized and its single crystal structure determined. The molecule crystallizes in a primitive monoclinic cell, with the space group P21/a (#14. The cell dimensions are a = 10.778(3Å, b = 13.809(3 Å, c = 11.420(2 Å, = 102.49(2°, volume = 1659.5(6 Å3.

  4. Kinetic analysis by DSC of the cationic curing of mixtures of DGEBA and 6,6-dimethyl (4,8-dioxaspiro[2.5]octane-5,7-dione)

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, Lidia [Departament de Quimica Analitica i Quimica Organica, Universitat Rovira i Virgili, C/Marcelli Domingo s/n, 43007 Tarragona (Spain); Ramis, Xavier [Laboratori de Termodinamica, ETSEIB, Universitat Politecnica de Catalunya, Av. Diagonal 647, 08028 Barcelona (Spain); Salla, Josep Maria [Laboratori de Termodinamica, ETSEIB, Universitat Politecnica de Catalunya, Av. Diagonal 647, 08028 Barcelona (Spain)], E-mail: salla@mmt.upc.edu; Mantecon, Ana; Serra, Angels [Departament de Quimica Analitica i Quimica Organica, Universitat Rovira i Virgili, C/Marcelli Domingo s/n, 43007 Tarragona (Spain)

    2007-11-25

    The kinetics of the thermal cationic cure reaction of mixtures in different proportions of diglycidylether of bisphenol A (DGEBA) with 6,6-dimethyl (4,8-dioxaspiro[2.5]octane-5,7-dione) (MCP) initiated by ytterbium or lanthanum triflates or using a conventional initiator, BF{sub 3}.MEA was investigated. The non-isothermal differential scanning calorimetry (DSC) experiments at a controlled heating rate was used for obtaining the kinetic parameters of the reactive systems. BF{sub 3}.MEA and lanthanide triflates initiated curing systems follow a complete different kinetic model. Among lanthanide triflates, ytterbium is the most active initiator.

  5. Determination of trace biogenic amines with 1,3,5,7-tetramethyl-8-(N-hydroxysuccinimidyl butyric ester)-difluoroboradiaza-s-indacene derivatization using high-performance liquid chromatography and fluorescence detection.

    Science.gov (United States)

    Gao, Pan-Feng; Guo, Xiao-Feng; Wang, Hong; Zhang, Hua-Shan

    2011-06-01

    A reversed-phase high-performance liquid chromatographic method based on chemical derivatization with fluorescence detection has been developed for analyzing biogenic amines in food and environmental samples. A BODIPY-based fluorescent reagent, 1,3,5,7-tetramethyl-8-(N-hydroxysuccinimidyl butyric ester)-difluoroboradiaza-s-indacene (TMBB-Su), was employed for the derivatization of these biogenic amines at 20 °C for 20 min in pH 7.20 borate buffer after careful investigation of the derivatization conditions including reagent concentration, buffer solution, reaction temperature and reaction time. Separation of biogenic amines with gradient elution was conducted on a C8 column with methanol-tetrahydrofuran-water as mobile phase. The detection limits were obtained in the range from 0.1 to 0.2 nM (signal-to-noise=3). This procedure has been validated using practical samples. The study results demonstrated a potential of employing high-performance liquid chromatography (HPLC) with 1,3,5,7-tetramethyl-8-(N-hydroxysuccinimidyl butyric ester)-difluoroboradiaza-s-indacene labeling as a tool for quantitative analysis of biogenic amines involved in various matrices.

  6. 5,7,3’,4’-四甲氧基黄酮对囊性纤维化跨膜转运调节因子的激活作用

    Institute of Scientific and Technical Information of China (English)

    孙亮

    2016-01-01

    囊性纤维化跨膜转运调节因子(CFTR),是一种受c AMP依赖的氯离子通道蛋白。CFTR在哺乳动物呼吸道和胃肠道粘膜等多种与分泌和吸收相关的上皮细胞内广泛表达,对上皮细胞的液体转运、盐类运输和离子浓度调节等具有重要的作用。CFTR功能障碍可能会引起诸如习惯性便秘等多种疾病。本实验利用细胞荧光淬灭方法测定了小分子黄酮类化合物5,7,3’,4’-四甲氧基黄酮对CFTR具有激活作用,为以CFTR作为分子靶标,用5,7,3’,4’-四甲氧基黄酮治疗CFTR相关疾病奠定了理论基础。

  7. Enhancement of laccase activity through the construction and breakdown of a hydrogen bond at the type I copper center in Escherichia coli CueO and the deletion mutant Δα5-7 CueO.

    Science.gov (United States)

    Kataoka, Kunishige; Hirota, Shun; Maeda, Yasuo; Kogi, Hiroki; Shinohara, Naoya; Sekimoto, Madoka; Sakurai, Takeshi

    2011-02-01

    CueO is a multicopper oxidase involved in a copper efflux system of Escherichia coli and has high cuprous oxidase activity but little or no oxidizing activity toward various organic substances. However, its activity toward oxidization of organic substrates was found to be considerably increased by the removal of the methionine-rich helical segment that covers the substrate-binding site (Δα5-7 CueO) [Kataoka, K., et al. (2007) J. Mol. Biol. 373, 141]. In the study presented here, mutations at Pro444 to construct a second NH-S hydrogen bond between the backbone amide and coordinating Cys500 thiolate of the type I copper are shown to result in positive shifts in the redox potential of this copper center and enhanced oxidase activity in CueO. Analogous enhancement of the activity of Δα5-7 CueO has been identified only in the Pro444Gly mutant because Pro444 mutants limit the incorporation of copper ions into the trinuclear copper center. The activities of both CueO and Δα5-7 CueO were also enhanced by mutations to break down the hydrogen bond between the imidazole group of His443 that is coordinated to the type I copper and the β-carboxy group of Asp439 that is located in the outer sphere of the type I copper center. A synergetic effect of the positive shift in the redox potential of the type I copper center and the increase in enzyme activity has been achieved by the double mutation of Pro444 and Asp439 of CueO. Absorption, circular dichroism, and resonance Raman spectra indicate that the characteristics of the Cu(II)-S(Cys) bond were only minimally perturbed by mutations involving formation or disruption of a hydrogen bond from the coordinating groups to the type I copper. This study provides widely applicable strategies for tuning the activities of multicopper oxidases.

  8. Beyond the Dimer and Trimer: Tetraspiro[2.1.2(5).1.2(9).1.2(13).1(3)] hexadecane-1,3,5,7-tetraone--the Cyclic Tetramer of Carbonylcyclopropane.

    Science.gov (United States)

    Sedenkova, Kseniya N; Averina, Elena B; Grishin, Yuri K; Andriasov, Kristian S; Stepanova, Svetlana A; Roznyatovsky, Vitaly A; Kutateladze, Andrei G; Rybakov, Victor B; Albov, Dmitry V; Kuznetsova, Tamara S; Zefirov, Nikolay S

    2016-03-14

    Tetraspiro[2.1.2(5).1.2(9).1.2(13).1(3)]hexadecane-1,3,5,7-tetraone 4, a unique tetraketone containing a cyclooctane core and four spiroannelated cyclopropane moieties, represents the previously unknown cyclotetramer of carbonylcyclopropane. For this purpose oxidation of the parent polyspirocyclic hydrocarbon was examined under various oxidative conditions, and the reactivity of oxidants towards methylene groups of the eight-membered cycle, activated by adjacent spirocyclopropane rings, was evaluated and contrasted. Whereas the treatment of tetraspirohexadecane with ozone resulted in monooxidation, its reaction with methyl(trifluoromethyl)dioxirane afforded the product of four-fold oxidation, triketoalcohol 10. Subsequent oxidation of the latter with Dess-Martin periodinane gave the target tetraketone 4.

  9. Variações de Mensuração pela Escala de Verificação: uma análise com escalas de 5, 7 e 11 pontos

    Directory of Open Access Journals (Sweden)

    Barboza, Stephanie Ingrid Souza

    2013-12-01

    Full Text Available This paper analyses the potential effect of multiple item scales’ number of points on the descriptive results and psychometric characteristics. A literature review was carried, followed by a field survey. The data were collected by means of 3 structured questionnaires to measure management student’s perception of profession reputation and personal identification. The metrics were adapted for scales of 5 (1 to 5, 7 (1 to 7 e 11 (0 to 10 points. The total sample had 285 respondents, and the procedures of analysis involved descriptive statistics and reliability analysis. The results indicated significant differences, although small ones, in the descriptive measures, on the other hand, the psychometric analyses had no variation related to the number of scale points. The main conclusion is that the use of scale with the 3 number of points can generate good results for researches; thus, the researcher may decide which scale use, considering the study’s needs and the sample characteristics.

  10. Peptide-nucleic acids (PNAs) with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone (PPT) as a universal base: their synthesis and binding affinity for oligodeoxyribonucleotides.

    Science.gov (United States)

    Hirano, Taisuke; Kuroda, Kenji; Kataoka, Masanori; Hayakawa, Yoshihiro

    2009-07-21

    Peptide-nucleic acids (PNAs) including pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone (PPT) as a nucleobase were synthesized, and their binding affinity for the complementary oligodeoxyribonucleotides was investigated. We found that PNAs with one or two PPT(s) and natural nucleobases (i.e., adenine, cytosine, guanine, or thymine) have excellent binding affinity for oligodeoxyribonucleotides with complementary bases at the positions facing the natural nucleobases, and with adenine, cytosine, guanine, and thymine at the positions opposite PPT in PNAs. The binding affinity of the PPT-containing PNA is higher than or comparable to that of a PNA consisting of all complementary natural nucleobases, viz. a PNA with a suitable natural nucleobase in place of PPT in the PPT-containing PNA. Consequently, it was concluded that PPT serves as a useful universal base that can recognize all natural nucleobases.

  11. (2-Carboxybenzoato-κ2O1,O1′(5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-κ4Nnickel(II perchlorate monohydrate

    Directory of Open Access Journals (Sweden)

    Guang-Chuan Ou

    2009-07-01

    Full Text Available The title compound, [Ni(C8H5O4(C16H36N4]ClO4·H2O, has the NiII atom in a distorted octahedral geometry, surrounded by coordination by four N atoms of the 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane ligand in a folded configuration, and two carboxylate O atoms of the 2-carboxybenzoate ligand in cis positions. The complex cation, the disordered perchlorate anion [occupancies 0.639 (8:0.361 (8] and uncoordinated water molecules engage in N—H...O and O—H...O hydrogen bonding, forming a layer structure parallel to (010.

  12. Eficacia de la anestesia de conducción para cesárea con dosis bajas de bupivacaina pesada al 0.5% 7mg más 0.120 mg de buprenorfina.

    OpenAIRE

    Castro Ferrín, María Rosita

    2014-01-01

    El presente estudio tiene como objetivo establecer la eficacia de la anestesia espinal utilizando dosis bajas de bupivacaína pesada al 0.5% 7 mg más 0.120 de buprenorfina en la operación cesárea programada. La hipótesis planteada en la investigación dice que si será eficaz la anestesia espinal mediante el uso de dosis bajas de bupivacaína pesada más buprenorfina en relación a las dosis habituales en cesárea. Se trató de un estudio longitudinal prospectivo, en un tiempo de 3 ...

  13. 5,7-dihydroxytryptamine lesions of dorsal and median raphé nuclei and performance in the social interaction test of anxiety and in a home-cage aggression test.

    Science.gov (United States)

    File, S E; Hyde, J R; MacLeod, N K

    1979-06-01

    Micro-injections of the neurotoxin 5,7-dihydroxytryptamine into the dorsal raphe nucleus produced a behavioural profile in the social interaction test of anxiety similar to that seen in rats treated chronically with benzodiazepines. Neurotoxin injections into the median raphé nucleus did not produce a profile significantly different from that of the controls. In the control rats and in the rats with lesions of the median raphé nucleus, ACTH1-24 (corticotrophin) significantly reduced active social interactions, whereas it was without effect on the rats with lesions of the dorsal raphé nucleus. In the home-cage intruder test, the median raphé-lesioned rats submitted less to the intruder and stood and jumped on him more often than did the controls. The dorsal raphé-lesioned rats showed significantly fewer interactions of all kinds, compared with control rats when an intruder was placed in their home cages.

  14. Development of Interpretive Theory of Mind in 5-to 7-year-old Children%5-7岁儿童解释性心理理论的发展

    Institute of Scientific and Technical Information of China (English)

    徐伟; 韩仁生

    2012-01-01

    Objective: To investigate the development of children's interpretive theory of mind. Methods: Chandler and Lalonde' s research paradigm was used to explore the development of false belief and interpretive theory of mind in 99 children aged 5-7. Results: False belief understanding was different from interpretive theory of mind; the former appeared earlier and it was an essential but not sufficient condition to the latter. The children's interpretive theory of mind appeared earlier but developed slowly. The key age of acquiring stable interpretive theory of mind was after 7 years old. Conclusion: Stable interpretive theory of mind was acquired after 7 years old.%目的:考察儿童解释性心理理论的发展.方法:基于Chandler和Lalonde的实验范式,对99名5-7岁儿童的错误信念和解释性心理理论进行了测量.结果:①错误信念理解不同于解释性心理理论,前者要早于后者出现,对后者来说是一种必要非充分条件;②儿童的解释性心理理论出现较早,但发展速度缓慢,儿童获得稳定的解释性心理理论的关键年龄在7岁之后.结论:稳定的解释性心理理论在7岁之后获得.

  15. Selective ablation of rabbit atherosclerotic plaque with less thermal effect by the control of pulse structure of a quantum cascade laser in the 5.7 μm wavelength range

    Science.gov (United States)

    Hashimura, Keisuke; Ishii, Katsunori; Awazu, Kunio

    2016-03-01

    Cholesteryl esters are main components of atherosclerotic plaques and have an absorption peak at the wavelength of 5.75 μm originated from C=O stretching vibration mode of ester bond. Our group achieved the selective ablation of atherosclerotic lesions using a quantum cascade laser (QCL) in the 5.7 μm wavelength range. QCLs are relatively new types of semiconductor lasers that can emit mid-infrared range. They are sufficiently compact and considered to be useful for clinical application. However, large thermal effects were observed because the QCL worked as quasicontinuous wave (CW) lasers due to its short pulse interval. Then we tried macro pulse irradiation (irradiation of pulses at intervals) of the QCL and achieved effective ablation with less-thermal effects than conventional quasi-CW irradiation. However, lesion selectivity might be changed by changing pulse structure. Therefore, in this study, irradiation effects of the macro pulse irradiation to rabbit atherosclerotic plaque and normal vessel were compared. The macro pulse width and the macro pulse interval were set to 0.5 and 12 ms, respectively, because the thermal relaxation time of rabbit normal and atherosclerotic aortas in the oscillation wavelength of the QCL was 0.5-12 ms. As a result, cutting difference was achieved between rabbit atherosclerotic and normal aortas by the macro pulse irradiation. Therefore, macro pulse irradiation of a QCL in the 5.7 μm wavelength range is effective for reducing thermal effects and selective ablation of the atherosclerotic plaque. QCLs have the potential of realizing less-invasive laser angioplasty.

  16. Superconducting Gravimeters Detect Gravity Fluctuations Induced by Mw 5.7 Earthquake Along South Pacific Rise Few Hours Before the 2011 Mw 9.0 Tohoku-Oki Earthquake

    Directory of Open Access Journals (Sweden)

    Keliang Zhang Jin Ma

    2014-01-01

    Full Text Available Gravity changes sometimes appear before a big earthquake. To determine the possible sources is important for recognizing the mechanism and further geodynamic studies. During the first two hours on March 11 before the Mw 9.0 Tohoku-Oki earthquake, the non-tidal gravity time series of superconducting gravimeters worldwide showed low-frequency (< 0.10 Hz fluctuations with amplitude of ~1 to 4 × 10-8 ms-2 lasting ~10 - 20 minutes. Through comparing global seismicity with the arrival times of seismic waves, we find that the fluctuations were induced by the Mw 5.7 earthquake that occurred at 0:14:54.68 at (53.27°S, 118.18°W along the eastern South Pacific Rise. Several body waves such as P, S are clearly recorded in the station with ~400 km distance to the hypocenter. The fluctuations are in response to the waves that propagate with a velocity of about 4 km s-1. Their amplitudes are proportional to the inverse of the epicentral distances even though the fluctuations of European sites were overlapped with waves associated with a smaller, i.e., Mw 2.6, event in Europe during this period. That is, the Mw 5.7 earthquake induced remarkable gravity fluctuations over long distances at stations all over the world. As such, the foreshocks with larger magnitudes occurred before the Mw 9.0 earthquake would have more significant influence on the gravity recordings and the seismic-wave induced component should be removed during the analysis of anomalies prior to a great earthquake in future studies.

  17. Superconducting Gravimeters Detect Gravity Fluctuations Induced by Mw 5.7 Earthquake Along South Pacific Rise Few Hours Before the 2011 Mw 9.0 Tohoku-Oki Earthquake

    Directory of Open Access Journals (Sweden)

    Keliang Zhang and Jin Ma

    2014-01-01

    Full Text Available Gravity changes sometimes appear before a big earthquake. To determine the possible sources is important for recognizing the mechanism and further geodynamic studies. During the first two hours on March 11 before the Mw 9.0 Tohoku-Oki earthquake, the non-tidal gravity time series of superconducting gravimeters worldwide showed low-frequency (< 0.10 Hz fluctuations with amplitude of ~1 to 4 ×× 10-8 ms-2 lasting ~10 - 20 minutes. Through comparing global seismicity with the arrival times of seismic waves, we find that the fluctuations were induced by the Mw 5.7 earthquake that occurred at 0:14:54.68 at (53.27°S,(53.27°S, 118.18°W118.18°W along the eastern South Pacific Rise. Several body waves such as P, S are clearly recorded in the station with ~400 km distance to the hypocenter. The fluctuations are in response to the waves that propagate with a velocity of about 4 km s-1. Their amplitudes are proportional to the inverse of the epicentral distances even though the fluctuations of European sites were overlapped with waves associated with a smaller, i.e., Mw 2.6, event in Europe during this period. That is, the Mw 5.7 earthquake induced remarkable gravity fluctuations over long distances at stations all over the world. As such, the foreshocks with larger magnitudes occurred before the Mw 9.0 earthquake would have more significant influence on the gravity recordings and the seismic-wave induced component should be removed during the analysis of anomalies prior to a great earthquake in future studies.

  18. Thin film assembly of nano-sized Zn(II)-8-hydroxy-5,7-dinitroquinolate by using successive ion layer adsorption and reaction (SILAR) technique: characterization and optical-electrical-photovoltaic properties.

    Science.gov (United States)

    Farag, A A M; Haggag, Sawsan M S; Mahmoud, Mohamed E

    2012-07-01

    A method is described for thin film assembly of nano-sized Zn(II)-8-hydroxy-5,7-dinitroquinolate complex, Zn[((NO(2))(2)-8HQ)(2)] by using successive ion layer adsorption and reaction (SILAR) technique. Highly homogeneous assembled nano-sized metal complex thin films with particle size distribution in the range 27-47nm was identified by using scanning electron microscopy (SEM). Zn[((NO(2))(2)-8HQ)(2)] and [(NO(2))(2)-8HQ] ligand were studied by thermal gravimetric analysis (TGA). Graphical representation of temperature dependence of the dark electrical conductivity produced two distinct linear parts for two activation energies at 0.377eV and 1.11eV. The analysis of the spectral behavior of the absorption coefficient in the intrinsic absorption region reveals a direct allowed transition with a fundamental band gap of 2.74eV. The dark current density-voltage (J-V) characteristics showed the rectification effect due to the formation of junction barrier of Zn[((NO(2))(2)-8HQ)(2)] complex film/n-Si interface. The photocurrent in the reverse direction is strongly increased by photo-illumination and the photovoltaic characteristics were also determined and evaluated.

  19. 5-7岁儿童特质理解的心理理论的发展%Development of 5-to 7-Year-Old Children's Trait-understanding in Theory of Mind

    Institute of Scientific and Technical Information of China (English)

    徐伟; 黄车白

    2010-01-01

    目的:考察儿童特质理解的心理理论的发展特点.方法:采用两个特质理解故事访谈了99名5-7岁儿童.结果:①5岁和7岁儿童的行为预测成绩差异显著;各年龄组儿童的情绪预测无显著差异;儿童行为预测和情绪预测的成绩没有显著差异.②除5岁组与6岁组之外.其他各组儿童在行为归因上的表现有显著差异;不同年龄组儿童在情绪归因上无显著差异;儿童在行为归因上的表现要显著好于情绪归因.结论:儿童的行为预测和情绪预测能力没有差别;行为归因要明显好于情绪归因.

  20. Report on the second WHO integrated meeting on development and clinical trials of influenza vaccines that induce broadly protective and long-lasting immune responses: Geneva, Switzerland, 5-7 May 2014.

    Science.gov (United States)

    Cox, Nancy J; Hickling, Julian; Jones, Rebecca; Rimmelzwaan, Guus F; Lambert, Linda C; Boslego, John; Rudenko, Larisa; Yeolekar, Leena; Robertson, James S; Hombach, Joachim; Ortiz, Justin R

    2015-11-27

    On 5-7 May 2014, the World Health Organization (WHO) convened the second integrated meeting on "influenza vaccines that induce broadly protective and long-lasting immune responses". Around 100 invited experts from academia, the vaccine industry, research and development funders, and regulatory and public health agencies attended the meeting. Areas covered included mechanisms of protection in natural influenza-virus infection and vaccine-induced immunity, new approaches to influenza-vaccine design and production, and novel routes of vaccine administration. A timely focus was on how this knowledge could be applied to both seasonal influenza and emerging viruses with pandemic potential such as influenza A (H7N9), currently circulating in China. Special attention was given to the development of possible universal influenza vaccines, given that the Global Vaccine Action Plan calls for at least one licensed universal influenza vaccine by 2020. This report highlights some of the topics discussed and provides an update on studies published since the report of the previous meeting.

  1. Synthesis, characterization and thermolysis studies on 3,7-dinitro-1,3,5,7-tetraazabicyclo[3,3,1]nonane (DPT): A key precursor in the synthesis of most powerful benchmark energetic materials (RDX/HMX) of today.

    Science.gov (United States)

    Radhakrishnan, S; Talawar, M B; Venugopalan, S; Narasimhan, V L

    2008-04-15

    This paper reports studies undertaken on 3,7-dinitro-1,3,5,7-tetraazabicyclo[3,3,1]nonane (DPT). The synthesis of DPT was carried out by the nitration of hexamine based on the lines of reported method with minor modification. DPT was characterized by elemental analysis, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) and (1)H nuclear magnetic resonance (NMR) techniques. Thermal stability of DPT was studied using thermogravimetry (TG) and differential scanning calorimetry (DSC). The thermal analysis studies revealed that DPT undergoes decomposition at 211 degrees C. Decomposition of DPT using TG-FTIR indicated the evolution of carbon dioxide, water and oxides of nitrogen as main gaseous products. The electrochemical behavior of DPT was studied using cyclic voltammetric (CV) studies. The experimentally determined sensitivity parameters indicated the insensitive nature of DPT towards external stimuli. The performance parameters of DPT, RDX and HMX have been computed using Linear Output Thermodynamic User Friendly Software for Energetic Systems (LOTUSES) code. The predicted properties of DPT are interesting and important from the point of process technology and/or safety. The work reported in this paper enriches the existing scanty research and development data on one of the key precursor used for synthesis of important high energy materials (HEMs).

  2. Thin film assembly of nano-sized Zn(II)-8-hydroxy-5,7-dinitroquinolate by using successive ion layer adsorption and reaction (SILAR) technique: Characterization and optical-electrical-photovoltaic properties

    Science.gov (United States)

    Farag, A. A. M.; Haggag, Sawsan M. S.; Mahmoud, Mohamed E.

    A method is described for thin film assembly of nano-sized Zn(II)-8-hydroxy-5,7-dinitroquinolate complex, Zn[((NO2)2-8HQ)2] by using successive ion layer adsorption and reaction (SILAR) technique. Highly homogeneous assembled nano-sized metal complex thin films with particle size distribution in the range 27-47 nm was identified by using scanning electron microscopy (SEM). Zn[((NO2)2-8HQ)2] and [(NO2)2-8HQ] ligand were studied by thermal gravimetric analysis (TGA). Graphical representation of temperature dependence of the dark electrical conductivity produced two distinct linear parts for two activation energies at 0.377 eV and 1.11 eV. The analysis of the spectral behavior of the absorption coefficient in the intrinsic absorption region reveals a direct allowed transition with a fundamental band gap of 2.74 eV. The dark current density-voltage (J-V) characteristics showed the rectification effect due to the formation of junction barrier of Zn[((NO2)2-8HQ)2] complex film/n-Si interface. The photocurrent in the reverse direction is strongly increased by photo-illumination and the photovoltaic characteristics were also determined and evaluated.

  3. Computational studies on the crystal structure, thermodynamic properties, detonation performance, and pyrolysis mechanism of 2,4,6,8-tetranitro-1,3,5,7-tetraazacubane as a novel high energy density material.

    Science.gov (United States)

    Wang, Fang; Du, Hongchen; Zhang, Jianying; Gong, Xuedong

    2011-10-27

    Studies have suggested that octanitrocubane (ONC) is one of the most powerful non-nuclear high energy density material (HEDM) currently known. 2,4,6,8-Tetranitro-1,3,5,7-tetraazacubane (TNTAC) studied in this work may also be a novel HEDM due to its high nitrogen content and crystal density. Density functional theory and molecular mechanics methods have been employed to study the crystal structure, IR spectrum, electronic structure, thermodynamic properties, gas-phase and condensed-phase heat of formation, detonation performance, and pyrolysis mechanism of TNTAC. The TNTAC has a predicted density of about 2.12 g/cm(3), and its detonation velocity (10.42 km/s) and detonation pressure (52.82 GPa) are higher than that of ONC. The crystalline packing is P2(1)2(1)2(1), and the corresponding cell parameters are Z = 4, a = 8.87 Å, b = 8.87 Å, and c = 11.47 Å. Both the density of states of the predicted crystal and the bond dissociation energy of the molecule in gas phase show that the cage C-N bond is the trigger bond during thermolysis. The activation energy of the pyrolysis initiation reaction obtained from the B3LYP/6-311++G(2df,2p) level is 125.98 kJ/mol, which indicates that TNTAC meets the thermal stability request as an exploitable HEDM.

  4. Preparation of low calorie structured lipids catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene(TBD)-functionalized mesoporous SBA-15 silica in a heterogeneous manner.

    Science.gov (United States)

    Xie, Wenlei; Qi, Cong

    2014-04-16

    1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD, a strong bicyclic guanidine base) functionalized SBA-15 material has been found to be an efficient solid catalyst for the interesterification between tributyrin and methyl stearate in a solvent-free system for the production of low-calorie structured lipid (LCSL). The solid base catalyst was characterized by using small-angle X-ray scattering, Fourier transform infrared spectra, thermo gravimetric analysis, scanning electron microscopy, transmission electron microscopy, nitrogen adsorption-desorption, and elemental analysis techniques. The obtained LCSL was analyzed by reverse-phase high-performance liquid chromatography for triacylglycerol composition. The influence of various reaction parameters, such as the substrate ratio, reaction temperature, and reaction time, on the interesterification reaction was investigated systematically. More than 90% LCSL was obtained at 80 °C within 1 h when the methyl stearate/tributyrin molar ratio of 2:1 was employed. The obtained solid catalyst could be recovered easily and reused for several recycles with a negligible loss of activity. By using the solid base catalyst, an eco-friendly more benign process for the interesterification reaction in a heterogeneous manner was developed.

  5. Report of the 2014 Cent Gardes HIV Vaccine Conference-Part 2: Cell-mediated immunity, mucosal protection, and clinical trials: Fondation Mérieux Conference Center, Veyrier du Lac, France, 5-7 October, 2014.

    Science.gov (United States)

    Girard, Marc P; Picot, Valentina; Longuet, Christophe; Nabel, Gary J

    2015-08-07

    The 2014 Cent Gardes Conference took place on October 5-7, 2014, at the Fondation Mérieux Conference Center, on the shores of the Annecy Lake and aimed to review the progress and promise of HIV vaccines. The elicitation of broadly neutralizing antibodies (bNAbs), their use in passive immunization, as well as their genetic delivery (vector immunoprophylaxis) by a recombinant Adenovirus-associated virus (AAV) vector were reviewed in a preceding article [1]. Approaches to the elicitation of long-lasting T cell or mucosal immunity were also discussed and are now reviewed here. The possibility of eliciting mucosal IgAs was discussed, since it was demonstrated that transcytosis-blocking IgAs can protect monkeys against repeated vaginal challenge with a pathogenic chimeric simian and human immunodeficiency virus (SHIV). The possibility of purging the HIV reservoirs from HIV-infected persons and developing a cure of the disease was also discussed. Copyright © 2015. Published by Elsevier Ltd.. All rights reserved.

  6. Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives.

    Science.gov (United States)

    Tian, Ye; Du, Deping; Rai, Diwakar; Wang, Liu; Liu, Huiqing; Zhan, Peng; De Clercq, Erik; Pannecouque, Christophe; Liu, Xinyong

    2014-04-01

    In our continuous efforts to identify novel potent HIV-1 NNRTIs, a novel class of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives were rationally designed, synthesized and evaluated for their anti-HIV activities in MT4 cell cultures. Biological results showed that most of the tested compounds displayed excellent activity against wild-type HIV-1 with a wide range of EC50 values from 5.98 to 0.07μM. Among the active compounds, 5a was found to be the most promising analogue with an EC50 of 0.07μM against wild-type HIV-1 and very high selectivity index (SI, 3999). Compound 5a was more effective than the reference drugs nevirapine (by 2-fold) and delavirdine (by 2-fold). In order to further confirm their binding target, an HIV-1 RT inhibitory assay was also performed. Furthermore, SAR analysis among the newly synthesized compounds was discussed and the binding mode of the active compound 5a was rationalized by molecular modeling studies.

  7. Heavy ion irradiations on synthetic hollandite-type materials: Ba1.0Cs0.3A2.3Ti5.7O16 (A=Cr, Fe, Al)

    Science.gov (United States)

    Tang, Ming; Tumurugoti, Priyatham; Clark, Braeden; Sundaram, S. K.; Amoroso, Jake; Marra, James; Sun, Cheng; Lu, Ping; Wang, Yongqiang; Jiang, Ying.-Bing.

    2016-07-01

    The hollandite supergroup of minerals has received considerable attention as a nuclear waste form for immobilization of Cs. The radiation stability of synthetic hollandite-type compounds described generally as Ba1.0Cs0.3A2.3Ti5.7O16 (A=Cr, Fe, Al) were evaluated by heavy ion (Kr) irradiations on polycrystalline single phase materials and multiphase materials incorporating the hollandite phases. Ion irradiation damage effects on these samples were examined using grazing incidence X-ray diffraction (GIXRD) and transmission electron microscopy (TEM). Single phase compounds possess tetragonal structure with space group I4/m. GIXRD and TEM observations revealed that 600 keV Kr irradiation-induced amorphization on single phase hollandites compounds occurred at a fluence between 2.5×1014 Kr/cm2 and 5×1014 Kr/cm2. The critical amorphization fluence of single phase hollandite compounds obtained by in situ 1 MeV Kr ion irradiation was around 3.25×1014 Kr/cm2. The hollandite phase exhibited similar amorphization susceptibility under Kr ion irradiation when incorporated into a multiphase system.

  8. Glass formation and mechanical properties of (Cu{sub 50}Zr{sub 50}){sub 100-x}Al{sub x} (x = 0, 4, 5, 7) bulk metallic glasses

    Energy Technology Data Exchange (ETDEWEB)

    Baser, T.A. [Dipartimento di Chimica IFM and NIS/INSTM/CNISM, University of Torino, Via P. Giuria 9, 10125 Torino (Italy); Das, J. [IFW Dresden, Institut fuer Komplexe Materialien, Helmholtzstrasse 20, D-01069 Dresden (Germany); Eckert, J. [IFW Dresden, Institut fuer Komplexe Materialien, Helmholtzstrasse 20, D-01069 Dresden (Germany); TU Dresden, Institut fuer Werkstoffwissenschaft, D-01062 Dresden (Germany); Baricco, M., E-mail: marcello.baricco@unito.i [Dipartimento di Chimica IFM and NIS/INSTM/CNISM, University of Torino, Via P. Giuria 9, 10125 Torino (Italy)

    2009-08-26

    The effect of Al content on the glass formation and mechanical properties was studied for (Cu{sub 50}Zr{sub 50}){sub 100-x}Al{sub x} (x = 0, 4, 5, 7) bulk metallic glasses. The crystallization temperatures of fully amorphous Cu{sub 50}Zr{sub 50}, Cu{sub 48}Zr{sub 48}Al{sub 4}, Cu{sub 47.5}Zr{sub 47.5}Al{sub 5} and Cu{sub 46.5}Zr{sub 46.5}Al{sub 7} as-cast rods are 724 K, 753 K, 758 K and 782 K, respectively. The mechanical properties were investigated under compression at room temperature. As-cast Cu{sub 46.5}Zr{sub 46.5}Al{sub 7} shows the highest yield strength (1867 MPa), whereas Cu{sub 47.5}Zr{sub 47.5}Al{sub 5} shows the largest fracture strain of 11.2%. The fracture surfaces of the compressed samples were investigated by scanning electron microscopy and their morphology has been correlated with the compressive plasticity.

  9. Solution phase photophysics of 5,7-dimethoxy-2,3,4,9-tetrahydro-1H-carbazol-1-one: Analysing the lineaments of a new fluorosensor to probe different micro-environments

    Energy Technology Data Exchange (ETDEWEB)

    Mitra, Amrit Krishna [Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata 700073 (India); Ghosh, Sujay; Sau, Abhishek [Chemical Sciences Division, Saha Institute of Nuclear Physics, Kolkata 700064 (India); Saha, Chandan [Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata 700073 (India); Basu, Samita, E-mail: samita.basu@saha.ac.in [Chemical Sciences Division, Saha Institute of Nuclear Physics, Kolkata 700064 (India)

    2015-11-15

    We present here a detailed photophysical study of a newly synthesised fluorophore 5,7-dimethoxy-2,3,4,9-tetrahydro-1H-carbazol-1-one (KTHC-57). Spectroscopic investigation of the compound has been carried out in 14 different protic and aprotic solvents, as well as in different binary solvent mixtures, using absorption, steady-state and time-resolved fluorescence techniques. The spectral behaviour of this compound is found to be extremely sensitive to the polarity and hydrogen bonding nature of the solvent. When considered in micelles, reverse micelles and β-cyclodextrin, KTHC-57 behaves as a reporter of its immediate microenvironment. Extent of hypsochromic shift varies as we move from cationic surfactant cetyltrimethylammonium bromide (~40 nm) to anionic surfactant sodium dodecyl sulphate (~23 nm) to non-ionic surfactant Triton X-100 (~37 nm). In case of anionic reverse micellar nanocavities composed of sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/heptane with increasing water contents, a bathochromic shift of ~50 nm is observed. A quantitative assessment of the emission intensity data on Benesi–Hildebrand equation reveals a 1:1 stoichiometry for KTHC-57:β-CD complex. Triethylamine (TEA) is a simple aliphatic organic molecule that interacts with KTHC-57 in polar aprotic medium. Within β-CD environment, fluorescence quenching takes place along with a bathochromic shift. Interaction of (TEA) with KTHC-57 in β-CD nano-confinement is studied using absorption spectroscopy, steady-state as well as time-resolved fluorescence spectroscopy and laser flash photolysis in conjunction with an external magnetic field. - Highlights: • Excited state properties of KTHC-57 vary with its H-bonding environment. • KTHC-57 interacts differently in various microheterogeneous environments. • Benesi–Hildebrand equation reveals a 1:1 stoichiometry for KTHC-57:β-CD complex. • Organic base TEA quench KTHC-57 fluorescence in polar aprotic solvents. • PET takes place from

  10. Construire une conception scientifique du vivant avec des élèves de 5-7 ans : approche didactique pour mieux comprendre les processus d’apprentissage et les enjeux développementaux

    Directory of Open Access Journals (Sweden)

    Grancher Céline

    2015-01-01

    Full Text Available Cet article s’intéresse au vivant en tant qu’objet de savoir et aux phénomènes d’enseignement-apprentissage de ce concept au début de l’école primaire en France (élèves de 5-7 ans, classes de CP-CE1. Nous nous interrogeons sur les contenus à enseigner et les situations possibles à mettre en oeuvre dans les classes pour que des élèves construisent une conception scientifique du vivant. Nous délimitons d’abord le concept de vivant dans une perspective d’enseignement à de jeunes élèves. Puis nous identifions un des enjeux de l’enseignement-apprentissage du vivant : permettre aux élèves de construire un autre rapport au vivant que celui de la vie de tous les jours. Nous abordons les situations scolaires comme des processus d’acculturation scientifique scolaire. Les élèves sont en effet incités à entrer dans une culture scientifique en s’appropriant à la fois des savoirs relatifs au vivant et des pratiques de la biologie. À partir de deux séquences d’enseignement réalisées en CP puis en CE1 avec les mêmes élèves, nous repérons des indicateurs qui témoignent de la construction d’une conception scientifique du vivant par les élèves. Nous montrons également que les processus d’acculturation scientifique dans lesquels les élèves sont engagés ont des effets sur leur développement.

  11. Antiferromagnetic spin correlations between corner-shared [FeO5]7- and [FeO6]9- units, in the novel iron-based compound: BaYFeO4.

    Science.gov (United States)

    Wrobel, Friederike; Kemei, Moureen C; Derakhshan, Shahab

    2013-03-04

    A novel quaternary compound in the Ba-Y-Fe-O phase diagram was synthesized by solid-state reaction and its crystal structure was characterized using powder X-ray diffraction. The crystal structure of BaYFeO4 consists of a unique arrangement of Fe(3+) magnetic ions, which is based on alternate corner-shared units of [FeO5](7-) square pyramids and [FeO6](9-) octahedra. This results in the formation of stairwise channels of FeO polyhedra along the b crystallographic axis. The structure is described in an orthorhombic crystal system in the space group Pnma with lattice parameters a = 13.14455(1) Å, b = 5.694960(5) Å, and c = 10.247630(9) Å. The temperature-dependent magnetic susceptibility data reveal two antiferromagnetic (AFM) transitions at 33 and 48 K. An upturn in the magnetic susceptibility data above these transitions is observed, which does not reach its maximum even at 390 K. The field-dependent magnetization data at both 2 and 300 K show a nearly linear dependence and do not exhibit significant hysteresis. Heat capacity measurements between 2 and 200 K reveal only a broad anomaly without any indication of long-range ordering. The latter data set is not in good agreement with the magnetic susceptibility data, which makes it difficult to exactly determine the magnetic ground state of BaYFeO4. Accordingly, a temperature-dependent neutron diffraction study is in order, which will enable resolving this issue. The theoretical study of the relative strengths of magnetic exchange interactions along various possible pathways, using extended Hückel spin dimer analysis, shows that only interactions between square pyramidal and octahedral centers are significant, and among them, the intrachannel correlations are stronger than interchannel interactions. This is the first physical property study in such a magnetic ion substructure.

  12. High-Performance Polymer Solar Cells Based on a Wide-Bandgap Polymer Containing Pyrrolo[3,4-f]benzotriazole-5,7-dione with a Power Conversion Efficiency of 8.63.

    Science.gov (United States)

    Lan, Liuyuan; Chen, Zhiming; Hu, Qin; Ying, Lei; Zhu, Rui; Liu, Feng; Russell, Thomas P; Huang, Fei; Cao, Yong

    2016-09-01

    A novel donor-acceptor type conjugated polymer based on a building block of 4,8-di(thien-2-yl)-6-octyl-2-octyl-5H-pyrrolo[3,4-f]benzotriazole-5,7(6H)-dione (TZBI) as the acceptor unit and 4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)-benzo-[1,2-b:4,5-b']dithiophene as the donor unit, named as PTZBIBDT, is developed and used as an electron-donating material in bulk-heterojunction polymer solar cells. The resulting copolymer exhibits a wide bandgap of 1.81 eV along with relatively deep highest occupied molecular orbital energy level of -5.34 eV. Based on the optimized processing conditions, including thermal annealing, and the use of a water/alcohol cathode interlayer, the single-junction polymer solar cell based on PTZBIBDT:PC71BM ([6,6]-phenyl-C71-butyric acid methyl ester) blend film affords a power conversion efficiency of 8.63% with an open-circuit voltage of 0.87 V, a short circuit current of 13.50 mA cm(-2), and a fill factor of 73.95%, which is among the highest values reported for wide-bandgap polymers-based single-junction organic solar cells. The morphology studies on the PTZBIBDT:PC71BM blend film indicate that a fibrillar network can be formed and the extent of phase separation can be mani-pulated by thermal annealing. These results indicate that the TZBI unit is a very promising building block for the synthesis of wide-bandgap polymers for high-performance single-junction and tandem (or multijunction) organic solar cells.

  13. Increased vascular eNOS and cystathionine-γ-lyase protein after 6 weeks oral administration of 3, 5, 7, 3', 4'-pentamethoxyflavone to middle-aged male rats.

    Science.gov (United States)

    Yorsin, Somruedee; Kanokwiroon, Kanyanatt; Radenahmad, Nisaudah; Jansakul, Chaweewan

    2016-11-01

    Effects of treatment of middle-aged male rats with 3, 5, 7, 3', 4'-pentamethoxyflavone (PMF) on vascular and perivascular adipose tissue (PVAT) functions and blood chemistry were investigated. Rats received PMF (22 mg/kg), orally or vehicle, twice a day for 6 weeks. The PMF-treated rats had lower serum glucose, higher HDL-C levels, but no change in other parameters. Thoracic aortic and mesenteric rings of PMF treated rats produced lower maximal contraction to phenylephrine that was normalized by N(G)-nitro-L-arginine (L-NA) or endothelial removal. The aortic- and mesenteric rings of the PMF treated rats showed improved relaxation to acetylcholine, but not to glyceryl trinitrate, and had higher eNOS protein. DL-propargylglycine (PAG) caused greater increase in the baseline tension of the PMF-treated aortic ring and higher contraction to low concentrations of phenylephrine. PVAT lowered the contractile response of the L-NA pretreated aortic rings to phenylephrine for both groups, but PAG had no effect. The cystathionine-γ-lyase (CSE) protein of the thoracic rings, but not of the PVAT, shows increased expression after PMF treatment. Overall, PMF treatment of middle aged rats appeared to increase production of NO and H2S from the blood vessels by upregulating the expression of eNOS and CSE. PMF also decreased fasting serum glucose and increased HDL-C levels, with no toxicity to liver and kidney functions. Thus, PMF is a novel compound for possible use as a health product to prevent and/or to reduce the development of diabetes type II and/or cardiovascular disease.

  14. Changes in the risk management of Salmonella enterica subspecies diarizonae serovar 61:(k):1, 5, (7) in Swedish sheep herds and sheep meat due to the results of a prevalence study 2012.

    Science.gov (United States)

    Sörén, Kaisa; Lindblad, Mats; Jernberg, Cecilia; Eriksson, Erik; Melin, Lennart; Wahlström, Helene; Lundh, Maria

    2015-02-03

    The prevalence of Salmonella in food producing animals is very low in Sweden due to rigorous control programmes. However, no active surveillance is in place in sheep. The authorities decided to perform a prevalence study in sheep herds because findings at slaughter indicated that sheep associated S. diarizonae (S. enterica subspecies diarizonae serovar 61:(k):1, 5, (7)) might be common in sheep. Sampling was stratified by herd size in two groups, small herds with ≤ 30 animals and large herds with > 30 animals. In each stratum, 237 herds were selected at random. Faecal samples received from 244 out of the 474 randomly selected herds were analysed. A total of 40 of 100 (40%) of large herds and 17 of 144 (12%) of small herds were positive. The overall adjusted prevalence was 17.6% (95% CI, 12.9-22.2). Sheep associated S. diarizonae was detected in all counties (n = 21). Scientific opinions and an evaluation of on-farm control measures performed concluded that the impact of sheep associated S. diarizonae on human health is very low, and that risk management measures applied in response to findings of sheep associated S. diarizonae in sheep or sheep meat can be expected to have very little impact on reducing risks to human health. As a result, Swedish authorities decided to make an exemption for sheep associated Salmonella diarizonae in sheep and sheep meat in the current Salmonella control measures. Sheep associated S. diarizonae is endemic in Swedish sheep herds. It is more common in large herds and not limited to certain parts of the country. The responsible authorities concluded that current risk management actions regarding sheep associated S. diarizonae in sheep and sheep meat are not proportional to the risk. This is the first time in the history of the Swedish Salmonella control programme that an exemption from the legislation has been made for a specific serovar. If there is any future indication of an increasing risk, due to e.g. change in the pathogenicity

  15. 1,3,5,7-Tetrakis(tetrazol-5-yl)-adamantane: the smallest tetrahedral tetrazole-functionalized ligand and its complexes formed by reaction with anhydrous M(II)Cl2 (M = Mn, Cu, Zn, Cd).

    Science.gov (United States)

    Boldog, Ishtvan; Domasevitch, Konstantin V; Sanchiz, Joaquín; Mayer, Peter; Janiak, Christoph

    2014-09-07

    1,3,5,7-Tetrakis(tetrazol-5-yl)-adamantane (H4L) was probed as a building block for the synthesis of tetrazolato/halido coordination polymers with open-network structures. MCl2 (M = Cu, Cd, Zn, Mn) was reacted with H4L in DMF at 70 °C to yield [Cu4Cl4L(DMF)5]·DMF, ; [Cd4Cl4L(DMF)7]·DMF, ; [Zn3Cl2L(DMF)4]·2DMF, and [Mn2L(DMF)2(MeOH)4]·DMF·2MeOH·2H2O, . and (Fddd) are nearly isostructural and have zeolitic structures with a {4(3)·6(2)·8}, gis or gismondine underlying net, where the role of the tetrahedral nodes is served by the coordination bonded clusters and the adamantane moiety. (P21/n) has a porous structure composed of coordination bonded layers with a (4·8(2)) fes topology joined via trans-{Zn(tetrazolate)2(DMF)4} pillars with an overall topology of {4·6(2)}{4·6(6)·8(3)}, fsc-3,5-Cmce-2. (Pca21) is composed of stacked {Mn2L} hexagonal networks. In and the ligand fulfills a symmetric role of a tetrahedral building block, while in and it fulfills rather a role of an effective trigonal unit. Methanol-exchanged and activated displayed an unusual type IV isotherm with H2 type hysteresis for N2 sorption with an expected uptake at high P/P0, but with a smaller SBET = 505.5 m(2) g(-1) compared to the calculated 1789 m(2) g(-1), which is a possible result of the framework's flexibility. For H2 sorption 0.79 wt% (1 bar, 77 K) and 0.06 wt% (1 bar, RT) uptake and Qst = -7.2 kJ mol(-1) heat of adsorption (77 K) were recorded. Weak antiferromagnetic interactions were found in and with J1 = -9.60(1), J2 = -17.2(2), J3 = -2.28(10) cm(-1) and J = -0.76 cm(-1) respectively. The formation of zeolitic structures in and , the concept of structural 'imprinting' of rigid building blocks, and design opportunities suggested as a potential hexafunctionalized biadamantane building block.

  16. 4',5,7-三羟基异黄酮抗骨髓瘤细胞增殖机制的研究%Inhibitory effect of genistein on the proliferation of multiple myeloma cell

    Institute of Scientific and Technical Information of China (English)

    翟明

    2008-01-01

    目的:为了研究4',5,7-三羟基异黄酮(genistein,Gen)是否能抑制人多发性骨髓瘤(multiple myeloma,MM)细胞株XGI的增殖,研究Gen处理骨髓瘤细胞后B细胞淋巴瘤,白血病.2基因0,c1.2)、bcl-xl、细胞周期蛋白D1(cyclin D1)、细胞间黏附因子1(ICMA-1)基因表达变化及骨髓瘤细胞中核转录因子κB(NF-κB)表达的变化.方法:利用体外培养人MM细胞株XG1,依据剂量梯度分别给予Gen,用噻唑蓝染色法(MTT)观察不同药物浓度的Gen对MM细胞的增殖影响;5、10、15μ/mL Gen与溶剂对照组分别作用XG1细胞48 h后,半定量逆转录聚合酶链反应(RT-PCR)法检测XG1细胞bcl-2、bcl-xl、细胞周期蛋白D1、ICMA-1基因表达;应用5 μg/mL Gen处理XG1细胞,用免疫组织化学法观察Gen处理前后细胞内NF.KB的表达情况.结果:Gen作用XG1细胞48 h,随浓度增加,细胞增殖逐渐下降;5、10、15 μg/mL Gen处理组mRNA的表达均低于溶剂对照组(P<0.05),伴随Gen处理浓度逐渐增加,bcl-2、bcl-xl、细胞周期蛋白D1、ICMA-1基因mRNA的表达逐渐下降;Gen能够使NF-κB在XG1细胞内重新分布,胞浆内出现NF-κB表达,胞核内NF-κB表达下降.结论:Gen可能通过下调骨髓瘤细胞核中NF-κB的表达来抑制bcl-2、bcl-xl、细胞周期蛋白D1、ICMA-1基因mRNA的表达,进而抑制骨髓瘤细胞的增殖、黏附、转移.

  17. Observation of spin alignment of resonances produced in the 3-body reactions : $\\overline{p}$p $\\rightarrow$ $\\overline{p}$p $\\omega^{\\omicron}$ and $\\overline{p}$p $\\rightarrow$ $\\overline{N}^{x++}\\pi^{\\omicron}$ at 5.7 GeV/c

    CERN Document Server

    Alles-Borelli, V; Frisk, A; Michejda, L

    1966-01-01

    Observation of spin alignment of resonances produced in the 3-body reactions : $\\overline{p}$p $\\rightarrow$ $\\overline{p}$p $\\omega^{\\omicron}$ and $\\overline{p}$p $\\rightarrow$ $\\overline{N}^{x++}\\pi^{\\omicron}$ at 5.7 GeV/c

  18. Synthesis of ceramic powders of La{sub 9,56} (SiO{sub 4}){sub 6}O{sub 2,34} and La{sub 9,8}Si{sub 5,7}Mg{sub O,3}O{sub 26,}4 by modified sol-gel process; Sintese de pos ceramicos de La{sub 9,56} (SiO{sub 4}){sub 6}O{sub 2,34} e La{sub 9,8}Si{sub 5,7}Mg{sub O,3}O{sub 26,}4 por processo sol-gel modificado

    Energy Technology Data Exchange (ETDEWEB)

    Lira, Sabrina Lopes; Paiva, Mayara Rafaela Soares; Misso, Agatha Matos; Elias, Daniel Ricco; Yamagata, Chieko, E-mail: yamagata@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (CCTM/IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Centro de Ciencia e Tecnologia de Materiais

    2012-07-01

    Lanthanum silicate oxyapatite materials are promising for application as electrolyte in solid oxide fuel cells because of high ionic conductivity at temperatures between 600 deg C and 800 deg C. In this work, oxyapatites with the composition La{sub 9,56}(SiO{sub 4}){sub 6}O{sub 2,34}, and La{sub 9,8}Si{sub 5,7}Mg{sub 0,3}O{sub 26,4} were synthesized by using the sol-gel method, followed by precipitation. Initially, the gel of silica was synthesized from sodium silicate solution, by acid catalysis using lanthanum and magnesium chloride solution. Then, the La and Mg hydroxides were precipitated with NaOH in the gel. The powders were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and measurements of specific surface area. The crystalline oxyapatite phase of La{sub 9,56}(SiO{sub 4}){sub 6}O{sub 2,34}, and was La{sub 9,8}Si{sub 5,7}Mg{sub 0,3}O{sub 26,4} obtained by calcination at 900 deg C for 2 and 1h respectively (author)

  19. Plant sterol metabolism. Δ7-Sterol-C5-Desaturase (STE1/DWARF7), Δ5,7-Sterol-Δ7-Reductase (DWARF5) and Δ24-Sterol-Δ24-Reductase (DIMINUTO/DWARF1) show multiple subcellular localizations in Arabidopsis thaliana (Heynh) L

    DEFF Research Database (Denmark)

    Silvestro, Daniele; Andersen, Tonni Grube; Schaller, Hubert;

    2013-01-01

    to contribute to cellular sterol homeostasis. To further document cellular aspects of sterol biosynthesis in plants, we addressed the question of the subcellular localization of the enzymes implicated in the final steps of the post-squalene biosynthetic pathway. In order to create a clear localization map...... of steroidogenic enzymes in cells, the coding regions of ¿(7)-sterol-C(5)-desaturase (STE1/DWARF7), ¿(24)-sterol-¿(24)-reductase (DIMINUTO/DWARF1) and ¿(5,7)-sterol-¿(7)-reductase (DWARF5) were fused to the yellow fluorescent protein (YFP) and transformed into Arabidopsis thaliana mutant lines deficient...... in the corresponding enzymes. All fusion proteins were found to localize in the endoplasmic reticulum in functionally complemented plants. The results show that both ¿(5,7)-sterol-¿(7)-reductase and ¿(24)-sterol-¿(24)-reductase are in addition localized to the plasma membrane, whereas ¿(7)-sterol-C(5)-desaturase...

  20. Haiku: It's Not Just 5-7-5.

    Science.gov (United States)

    Yarrow, Ruth

    1982-01-01

    Notes the relevance of the haiku form (unrhymed poetry "recording the essence of a moment keenly perceived in which nature is linked to human nature") to outdoor education. Lists anthologies, collections, books introducing haiku, and haiku magazines. Provides 17 haiku examples. (MH)

  1. 5,7-Dimethoxycoumarin inhibits neuronal apoptosis by targeting ...

    African Journals Online (AJOL)

    However, those in the normal control and model groups received the same volume of ... cerebral infarction in animals the rate of neuronal apoptosis is ... Department of Health and Human Services, and guidelines ... The complex development was performed using an ECL .... and reproduction in any medium, provided the.

  2. Recommended Water Quality Criteria for Octahydro-1,3,5,7-Tentranitro-1, 3,5,7-Tetrazocin (HMX).

    Science.gov (United States)

    1989-03-27

    given solvent than RDX Specific heat, J (.g X K): 1.26 Heat of formation, kJ/g: -0.253 Heat of combustion , kJ/g: 9.43 Heat of detonation, kJ/g: 5.67 Heat...species of blue-green algae, Microcystis aeruinosa and Anabaena flos- aguae , the green alga Selenastrum caoricornutum, and the diatom Navicula pelliculosa...incineration processes, material to be disposed of is conveyed into the heated zone of a furnace, where both pyrolysis and combustion occur. In a second

  3. Polymer Solar Cells: High‐Performance Polymer Solar Cells Based on a Wide‐Bandgap Polymer Containing Pyrrolo[3,4‐f]benzotriazole‐5,7‐dione with a Power Conversion Efficiency of 8.63% (Adv. Sci. 9/2016)

    OpenAIRE

    Lan, Liuyuan; Chen, Zhiming; Hu, Qin; Ying, Lei; Zhu, Rui; Liu, Feng(Central China Normal University, Wuhan, 430079, People's Republic of China); Russell, Thomas P.; Huang, Fei; Cao, Yong

    2016-01-01

    In article 1600032, an efficient new wide‐bandgap polymer based on a novel moiety of pyrrolo[3,4‐f]benzotriazole‐5,7‐dione (TZBI) is developed by Lei Ying, Feng Lui, Thomas P. Russel, Fei Huang, and co‐workers. The new chemistry enables fine electronic structure tuning and solution‐processed single‐junction polymer solar cells provided a remarkable power conversion efficiency of 8.63%. Full electrical and structural characterization reveales that TZBI is a promising building block for the app...

  4. Distorted octahedral environments in tricarbonylrhenium(I) complexes of 5-[2-(2,4,6-trimethylphenyl)diazen-1-yl]quinolin-8-olate and 5,7-bis[2-(2-methylphenyl)diazen-1-yl]quinolin-8-olate.

    Science.gov (United States)

    Schutte-Smith, Marietjie; Muller, Theunis J; Visser, Hendrik G; Roodt, Andreas

    2013-12-15

    The Re(I) centres of two Re(I)-tricarbonyl complexes, viz. tricarbonyl(pyridine-κN){5-[2-(2,4,6-trimethylphenyl)diazen-1-yl]quinolin-8-olato-κ(2)N(1),O}rhenium(I), [Re(C23H21N4O)(CO)3], (I), and {5,7-bis[2-(2-methylphenyl)diazen-1-yl]quinolin-8-olato-κ(2)N(1),O}tricarbonyl(pyridine-κN)rhenium(I), [Re(C28H23N6O)(CO)3], (II), are facially surrounded by three carbonyl ligands, a pyridine ligand and either a 5-[2-(2,4,6-trimethylphenyl)diazen-1-yl]quinolin-8-olate [in (I)] or a 5,7-bis[2-(2-methylphenyl)diazen-1-yl]quinolin-8-olate [in (II)] ligand, in a slightly distorted octahedral environment. The crystal structure of (I) is stabilized by two intermolecular C-H···O interactions and that of (II) is stabilized by three intermolecular C-H···O hydrogen-bonding interactions.

  5. The in vitro and in vivo antimalarial activity of some Mannich bases derived from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol, 2-(7'-trifluoromethyl-quinolin-4'-ylamino)phenol, and 4'-chloro-5-(7''-trifluoromethylquinolin-4''-ylamino)biphenyl -2-ols.

    Science.gov (United States)

    Barlin, G B; Jiravinyu, C; Butcher, G A; Kotecka, B; Rieckmann, K

    1992-08-01

    A series of di-Mannich base derivatives (4 and 5) from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and 2-(7'-trifluoromethylquinolin-4'-ylamino)phenol, respectively, and mono-Mannich base derivatives (6) from 4'-chloro-5-(7''-trifluoromethylquinolin-4''- ylamino)biphenyl-2-ol were assayed for activity against the chloroquine-sensitive (FCQ-27) isolate of cultured Plasmodium falciparum using the inhibition of uptake of radiolabelled hypoxanthine. All seven di-Mannich base derivatives (5) revealed a higher activity than chloroquine, whereas the di-Mannich base derivatives (4) were slightly less active (with some derivatives more active and some less active than chloroquine). The mono-Mannich base derivatives (6) were less active than chloroquine. Comparative tests of selected compounds of (4 and 5) using a morphological assay revealed no significant differences in activity between the chloroquine-sensitive (FCQ-27) and chloroquine-resistant (K-1) isolates. Selected di-Mannich bases (4 and 5) and the mono-Mannich bases 5-7''-bromo (and 7-trifluoromethyl)-1'',5''-naphthyridin-4''-ylamino)-3-(t- butylaminomethyl)-4'-chlorobiphenyl-2-ols (7, X = Br, CF3) markedly suppressed parasitaemia in Plasmodium vinckei vinckei infected mice when administered (i.p.) in a single dose of 200 mg kg-1.

  6. Plant sterol metabolism. Δ(7-Sterol-C5-desaturase (STE1/DWARF7, Δ(5,7-sterol-Δ(7-reductase (DWARF5 and Δ(24-sterol-Δ(24-reductase (DIMINUTO/DWARF1 show multiple subcellular localizations in Arabidopsis thaliana (Heynh L.

    Directory of Open Access Journals (Sweden)

    Daniele Silvestro

    Full Text Available Sterols are crucial lipid components that regulate membrane permeability and fluidity and are the precursors of bioactive steroids. The plant sterols exist as three major forms, free sterols, steryl glycosides and steryl esters. The storage of steryl esters in lipid droplets has been shown to contribute to cellular sterol homeostasis. To further document cellular aspects of sterol biosynthesis in plants, we addressed the question of the subcellular localization of the enzymes implicated in the final steps of the post-squalene biosynthetic pathway. In order to create a clear localization map of steroidogenic enzymes in cells, the coding regions of Δ(7-sterol-C(5-desaturase (STE1/DWARF7, Δ(24-sterol-Δ(24-reductase (DIMINUTO/DWARF1 and Δ(5,7-sterol-Δ(7-reductase (DWARF5 were fused to the yellow fluorescent protein (YFP and transformed into Arabidopsis thaliana mutant lines deficient in the corresponding enzymes. All fusion proteins were found to localize in the endoplasmic reticulum in functionally complemented plants. The results show that both Δ(5,7-sterol-Δ(7-reductase and Δ(24-sterol-Δ(24-reductase are in addition localized to the plasma membrane, whereas Δ(7-sterol-C(5-desaturase was clearly detected in lipid particles. These findings raise new challenging questions about the spatial and dynamic cellular organization of sterol biosynthesis in plants.

  7. Effects of genistein on PCNA expression and cell cycle in human hypertrophic scar fibroblasts in vitro%5,7,4′-三羟基异黄酮对增生性瘢痕成纤维细胞增殖细胞核抗原表达及细胞周期的影响

    Institute of Scientific and Technical Information of China (English)

    曹川; 李世荣; 姚恒; 冯智; 戴霞; 陈艳清; 李晓格; 陈亮

    2008-01-01

    目的 观察5,7,4′-三羟基异黄酮(genistein)对增生性瘢痕成纤维细胞增殖细胞核抗原(proliferating cell nuclear antigen, PCNA)及细胞周期的影响,探讨5,7,4′-三羟基异黄酮抑制增生性瘢痕成纤维细胞增殖的机制.方法 分离培养人增生性瘢痕成纤维细胞,分别加入25、50、100 μmol/L浓度的5,7,4′-三羟基异黄酮共培养48 h,免疫细胞化学法观察成纤维细胞PCNA蛋白的表达,流式细胞术检测细胞周期的变化.结果 各组5,7,4′-三羟基异黄酮作用后细胞PCNA的表达均降低(P<0.05),50 μmol/L及100 μmol/L浓度组的抑制作用最为显著(P<0.01);随药物浓度的增加,G0~G1期细胞比例逐渐下降,G2~M期细胞比例增加,表明细胞分裂受到抑制;100 μmol/L组的S期细胞数量比例也有增加,并于G1期前出现亚二倍体凋亡峰.结论 5,7,4′-三羟基异黄酮可通过影响细胞分裂与DNA合成抑制瘢痕增生.%Objective To observe the effects of genistein on PCNA expression and cell cycle in fibroblasts derived from human hypertrophic scar in order to explore the mechanism of its inhibition on hypertrophic scar (HS) fibroblast proliferation. Methods The human hypertrophic scar fibroblasts were cultured in vitro. Genistein with various concentrations (25, 50, 100 μmol/L) was co-cultured in the medium for 48 hours. The expression of PCNA was detected with immunocytochemical staining method and the cell cycle was measured with flow cytometry. Results Genistein could significantly decrease PCNA expression in HS fibroblasts, especially when its concentration at 50 μmol/L or 100 μmol/L. The cell percentage of G0~G1 phase decreased with drug′s concentration, and G2~M percentage increased conversely, implying the suspension of mitosis. In 100 μmol/L group, most cells blocked at S phase and a hypodiploid apoptosis peak could be observed ahead of G1 phase. Conclusion Genistein can inhibit the proliferation of human

  8. Plant sterol metabolism. Δ7-Sterol-C5-Desaturase (STE1/DWARF7), Δ5,7-Sterol-Δ7-Reductase (DWARF5) and Δ24-Sterol-Δ24-Reductase (DIMINUTO/DWARF1) show multiple subcellular localizations in Arabidopsis thaliana (Heynh) L

    DEFF Research Database (Denmark)

    Silvestro, Daniele; Andersen, Tonni Grube; Schaller, Hubert

    2013-01-01

    Sterols are crucial lipid components that regulate membrane permeability and fluidity and are the precursors of bioactive steroids. The plant sterols exist as three major forms, free sterols, steryl glycosides and steryl esters. The storage of steryl esters in lipid droplets has been shown...... to contribute to cellular sterol homeostasis. To further document cellular aspects of sterol biosynthesis in plants, we addressed the question of the subcellular localization of the enzymes implicated in the final steps of the post-squalene biosynthetic pathway. In order to create a clear localization map...... of steroidogenic enzymes in cells, the coding regions of ¿(7)-sterol-C(5)-desaturase (STE1/DWARF7), ¿(24)-sterol-¿(24)-reductase (DIMINUTO/DWARF1) and ¿(5,7)-sterol-¿(7)-reductase (DWARF5) were fused to the yellow fluorescent protein (YFP) and transformed into Arabidopsis thaliana mutant lines deficient...

  9. Melt Processed Single Phase Hollandite Waste Forms For Nuclear Waste Immobilization: Ba{sub 1.0}Cs{sub 0.3}A{sub 2.3}Ti{sub 5.7}O{sub 16}; A = Cr, Fe, Al

    Energy Technology Data Exchange (ETDEWEB)

    Brinkman, Kyle [Savannah River National Laboratory, Aiken, SC 29808 (United States); Marra, James [Savannah River National Laboratory, Aiken, SC 29808 (United States); Amoroso, Jake [Savannah River National Laboratory, Aiken, SC 29808 (United States); Conradson, Steven D. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Tang, Ming [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2013-09-23

    Cs is one of the more problematic fission product radionuclides to immobilize due to its high volatility at elevated temperatures, ability to form water soluble compounds, and its mobility in many host materials. The hollandite structure is a promising crystalline host for Cs immobilization and has been traditionally fabricated by solid state sintering methods. This study presents the structure and performance of Ba{sub 1.0}Cs{sub 0.3}A{sub 2.3}Ti{sub 5.7}O{sub 16}; A = Cr, Fe, Al hollandite fabricated by melt processing. Melt processing is considered advantageous given that melters are currently in use for High Level Waste (HLW) vitrification in several countries. This work details the impact of Cr additions that were demonstrated to i) promote the formation of a Cs containing hollandite phase and ii) maintain the stability of the hollandite phase in reducing conditions anticipated for multiphase waste form processing.

  10. Melt processed single phase hollandite waste forms for nuclear waste immobilization: Ba{sub 1.0}Cs{sub 0.3}A{sub 2.3}Ti{sub 5.7}O{sub 16}; A = Cr, Fe, Al

    Energy Technology Data Exchange (ETDEWEB)

    Amoroso, Jake; Marra, James [Savannah River National Laboratory, Aiken, SC 29808 (United States); Conradson, Steven D.; Tang, Ming [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Brinkman, Kyle, E-mail: kyle.brinkman@srnl.doe.gov [Savannah River National Laboratory, Aiken, SC 29808 (United States)

    2014-01-25

    Highlights: • This work shows Cr additions improve the performance of Ba{sub 1.0}Cs{sub 0.3}A{sub 2.3}Ti{sub 5.7}O{sub 16}; A = Cr, Fe, Al hollandite • Fe–Hol sample exhibited the least Cs retention whereas the Cr–Hol exhibited the greatest Cs retention. • CAF–Hol and Fe–Hol samples exhibited secondary phases enriched in Cs. • X-ray absorption measurements confirmed the stability of Cr{sup +3} as compared to Fe{sup +3}. -- Abstract: Cs is one of the more problematic fission product radionuclides to immobilize due to its high volatility at elevated temperatures, ability to form water soluble compounds, and its mobility in many host materials. The hollandite structure is a promising crystalline host for Cs immobilization and has been traditionally fabricated by solid state sintering methods. This study presents the structure and performance of Ba{sub 1.0}Cs{sub 0.3}A{sub 2.3}Ti{sub 5.7}O{sub 16}; A = Cr, Fe, Al hollandite fabricated by melt processing. Melt processing is considered advantageous given that melters are currently in use for High Level Waste (HLW) vitrification in several countries. This work details the impact of Cr additions that were demonstrated to (i) promote the formation of a Cs containing hollandite phase and (ii) maintain the stability of the hollandite phase in reducing conditions anticipated for multiphase waste form processing.

  11. Haigekassa võitleb reklaamiga laste liigse magusalembuse vastu / Agnes Kuus

    Index Scriptorium Estoniae

    Kuus, Agnes

    2006-01-01

    11-15 aastastele noortele suunatud hoiatavast reklaamikampaaniast. Kommenteerivad Tallinna Lastehaigla endokrinoloog Ülle Einberg ja Hambaarstide liidu juhatuse esimees Kristjan Gutmann. Lisa: Kampaaniaga pahest lahti

  12. 水杨醛缩5,7-二溴-8-氨基喹啉荧光光度法 测定粮食中的痕量锌%Synthesis of New Schiff′s Base SABAQ and Its Application in Fluorimetric Determination of Trace Amounts of Zinc in Crops

    Institute of Scientific and Technical Information of China (English)

    康信煌

    2001-01-01

    合成了新型息夫碱类试剂水杨醛5,7-二溴-8-氨基喹啉,建立了该试剂荧光光度法测定痕量锌(Ⅱ)的新体系,在pH5~6范围内,50%(V/V)乙醇的溶液中,试剂与锌(Ⅱ)的络合比为2∶1,λex/λem=400nm/475nm,线性范围为0~288μg/L,检出限为1.4μg/L,考察了共存离子的影响,已应用于粮食中痕量锌的测定。%A new shiff′s basesalicylaldehyde-5,7-dibrom-8-aminoquinoline(SABAQ) was prepared and its characteristics were studied. The optimal conditions for the formation of complex of SABAQ with Zn(Ⅱ)were established.The molar ratio of Zn to SABAQ was determined to be 1∶2. The proposed method was used for determination of Zn in crops in the range of 0~288 μg/L.

  13. The Novel Polymorphic Form of Bis(3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane bis(μ4-oxo-tris(μ3-oxo-nonakis(μ2-oxo-nonaaqua-decaoxo-hepta-molybdenum-di-zinc(II dihydrate, Synthesis, and Properties

    Directory of Open Access Journals (Sweden)

    Rafal Kruszynski

    2012-01-01

    Full Text Available The reaction of molybdophosphoric acid with zinc carbonate followed by addition of hmta leads to formation of a triclinic polymorph of bis(3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane bis(μ4-oxo-tris(μ3-oxo-nonakis(μ2-oxo-nonaaqua-decaoxo-hepta-molybdenum-di-zinc(II dihydrate in a one pot simple reaction. The obtained compound has been characterised by IR, UV-Vis spectroscopy, elemental analysis, and X-ray crystallography. A detailed comparison between both polymorphic forms: triclinic a=22.758 Å, b=24.702 Å, c=31.995 Å, α=101.206°, β=103.256°, γ=105.736°, and V=16203.8 Å3 and monoclinic a=43.120 Å, b=12.399 Å, c=16.285 Å, α=90.00°, β=111.12°, γ=90.00°, and V=8122 Å3 was performed. The influence of the synthesis procedure on polymorph formation was described.

  14. Effect of apigeninon on invasive potential and growth of human breast cancer cells%4′,5,7-三羟基黄酮,芹菜配基对人乳腺癌细胞生长和侵袭潜力的影响

    Institute of Scientific and Technical Information of China (English)

    石远; 任国胜; 王小毅; 王良

    2005-01-01

    目的探讨透明质酸酶(Hyaluronidase,Hyase)抑制剂4′,5,7-三羟基黄酮,芹菜配基(Apigenin)对人乳腺癌细胞生长、增殖及侵袭潜力的影响.方法通过体外侵袭模型观察Apigenin对人乳腺癌细胞穿透Matrigel(人工基底膜)能力的影响;MTT法和流式细胞仪检测Apigenin对人乳腺癌细胞株生长和增殖的影响.结果 8株人乳腺癌细胞的侵袭潜力存在明显差异,加用Apigenin后其侵袭潜力均明显降低(P<0.05),并与Apigenin存在量效关系;Apigenin对MDA-MB-435S和T47D细胞株的生长抑制作用均呈浓度依赖性;流式细胞仪显示Apigenin阻滞人乳腺癌细胞株MDA-MB-231和ZR-75-30生长于G2/M期(P<0.05).结论 Apigenin可抑制人乳腺癌细胞的增殖和Hyase的表达,并可降低人乳腺癌细胞株的侵袭潜能.

  15. Target and beam-target spin asymmetries in exclusive π+ and π- electroproduction with 1.6- to 5.7-GeV electrons

    Energy Technology Data Exchange (ETDEWEB)

    Bosted, P. E.; Biselli, A. S.; Careccia, S.; Dodge, G.; Fersch, R.; Guler, N.; Kuhn, S. E.; Pierce, J.; Prok, Y.; Zheng, X.; Adhikari, K. P.; Adikaram, D.; Akbar, Z.; Amaryan, M. J.; Anefalos Pereira, S.; Asryan, G.; Avakian, H.; Badui, R. A.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Boiarinov, S.; Briscoe, W. J.; Bültmann, S.; Burkert, V. D.; Cao, T.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Chetry, T.; Ciullo, G.; Clark, L.; Colaneri, L.; Cole, P. L.; Contalbrigo, M.; Cortes, O.; Crede, V.; D' Angelo, A.; Dashyan, N.; De Vita, R.; Deur, A.; Djalali, C.; Dupre, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Eugenio, P.; Fanchini, E.; Fedotov, G.; Filippi, A.; Fleming, J. A.; Forest, T. A.; Fradi, A.; Garçon, M.; Gevorgyan, N.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gleason, C.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guo, L.; Hafidi, K.; Hanretty, C.; Harrison, N.; Hattawy, M.; Heddle, D.; Hicks, K.; Holtrop, M.; Hughes, S. M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jenkins, D.; Jiang, H.; Jo, H. S.; Joo, K.; Joosten, S.; Keller, D.; Khandaker, M.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuleshov, S. V.; Lanza, L.; Lenisa, P.; Livingston, K.; Lu, H. Y.; MacGregor, I. J. D.; Markov, N.; McCracken, M. E.; McKinnon, B.; Meyer, C. A.; Minehart, R.; Mirazita, M.; Mokeev, V.; Movsisyan, A.; Munevar, E.; Munoz Camacho, C.; Nadel-Turonski, P.; Net, L. A.; Ni, A.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Paremuzyan, R.; Park, K.; Pasyuk, E.; Peng, P.; Phelps, W.; Pisano, S.; Pogorelko, O.; Price, J. W.; Procureur, S.; Protopopescu, D.; Puckett, A. J. R.; Raue, B. A.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schumacher, R. A.; Seder, E.; Sharabian, Y. G.; Simonyan, A.; Skorodumina, Iu.; Smith, G. D.; Sparveris, N.; Stankovic, Ivana; Stepanyan, S.; Strakovsky, I. I.; Strauch, S.; Sytnik, V.; Taiuti, M.; Tian, Ye; Torayev, B.; Ungaro, M.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D. P.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.

    2016-11-01

    Beam-target double-spin asymmetries and target single-spin asymmetries in exclusive pi(+) and quasiexclusive pi(-) electroproduction were obtained from scattering of 1.6- to 5.7-GeV longitudinally polarized electrons from longitudinally polarized protons (for pi(+)) and deuterons (for pi(-)) using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. The kinematic range covered is 1.1 < W < 2.6 GeV and 0.05 < Q(2) < 5 GeV2, with good angular coverage in the forward hemisphere. The asymmetry results were divided into approximately 40 000 kinematic bins for pi(+) from free protons and 15 000 bins for pi(-) production from bound nucleons in the deuteron. The present results are found to be in reasonable agreement with fits to previous world data for W < 1.7 GeV and Q(2) < 0.5 GeV2, with discrepancies increasing at higher values of Q(2), especially for W > 1.5 GeV. Very large target-spin asymmetries are observed for W > 1.6 GeV. When combined with cross-section measurements, the present results can provide powerful constraints on nucleon resonance amplitudes at moderate and large values of Q(2), for resonances with masses as high as 2.3 GeV.

  16. May-July Temperature Variability Since 1801 Inferred from Tree Rings of Pinus tabulaeformis of Helan Mountains in China%树轮记录的贺兰山北部近208年5-7月温度变化

    Institute of Scientific and Technical Information of China (English)

    陈峰; 袁玉江; 魏文寿; 张同文; 张瑞波; 喻树龙; 范子昂; 李杨; 尚华明

    2011-01-01

    利用2008年10月采自贺兰山北部的油松树轮样本建立了贺兰山北部区域树轮密度年表.相关分析表明:贺兰山北部的树轮早材平均密度与银川气象站5-7月平均最高温度具有较好的正相关关系,相关系数为0.67.用贺兰山北部的区域早材平均密度差值年表重建贺兰山北部1801-2008年的5-7月平均最高温度,58年(1951-2008年)重建值对实测值的解释方差为44.9% 2008年的贺兰山北部温度重建序列平均值为27.40℃.在最近20年,贺兰山树轮早材平均密度出现了明显的上升趋势,通过比对贺兰山北部重建序列的低温年份和全球火山爆发数据,发现在大规模火山爆发后的28个偏冷年温度平均值为26.90℃,较重建序列平均值下降0.50℃.多窗谱分析表明:贺兰山北部温度重建序列具有120年、8.1年、6.5年、3.2年、2.9年、2.1年的准周期变化.贺兰山北部早材平均密度与甘肃石门山、昌灵山油松的早材平均密度有良好的相关性.%Ninety newly measured tree-ring width and density series from Chinese Pines (Pinus tabulaeformis) from four sites in Helan Mountains are compiled. To remove non-climatic, age-related growth trends from the raw tree-ring width and density measurement series, while allowing lower frequency information above the mean segment length to be preserved, the program ARSTAN is used to detrend the ring width and density sequences using hugershoff growth curve and to average the standardized ring width and density sequences into the master chronologies. The correlating coefficient between earlywood density record and May-July maximum temperature of Yinchuan reaches up to 0. 67 during 1951-2008. The May-July maximum temperature reconstruction (1801-2008) uses the earlywood density chronologies from the region. The explained variance of model is 44. 9% (F=45. 625, P<0. 0001). The mean temperature over the 1801-2008 periods is estimated to be 27. 4 ℃. The

  17. Expertise, following the 5.7.1977 decree: assessment of the procedure; Expertise, arrete du 5.7.77 - bilan de la procedure

    Energy Technology Data Exchange (ETDEWEB)

    Maillard, M. [Ministere de l`Industrie, des Postes et Telecommunications, 75 - Paris (France)

    1996-12-31

    The French Government decree concerning the periodical inspection and extensive examination procedure for plants and buildings where thermal energy is consumed, is presented. The inspection procedure is intended to control the thermal and electrical equipment, the regulation systems, the pollutant emission control systems and the waste heat recovery systems. Design recommendations, fuel substitution, pollution abatement, waste heat up-grading, etc. may be proposed by the expert

  18. 5 7 Fe Emission Mössbauer Study on Gd 3 Ga 5 O 1 2 implanted with dilute 5 7 Mn

    Science.gov (United States)

    Krastev, P. B.; Gunnlaugsson, H. P.; Nomura, K.; Adoons, V.; Gerami, A. M.; Johnston, K.; Ncube, M.; Mantovan, R.; Masenda, H.; Matveyev, Y. A.; Mølholt, T. E.; Unzueta, I.; Bharuth-Ram, K.; Gislason, H.; Langouche, G.; Naidoo, D.; Ólafsson, S.

    2016-12-01

    57Fe emission Mössbauer spectroscopy has been applied to study the lattice location and properties of Fe in gadolinium gallium garnet Gd3Ga5 O 12 (GGG) single crystals in the temperature interval 300 - 563 K within the extremely dilute (CERN. These results are compared with earlier Mössbauer spectroscopy study of Fe-doped gadolinium gallium garnet Gd3Ga5 O 12(GGG), with implantation fluences between 8×1015 and 6×1016 atoms cm-2. Three Fe components are observed in the emission Mössbauer spectra: (i) high spin Fe2+ located at damage sites due to the implantation process, (ii) high spin Fe3+ at substitutional tetrahedral Ga sites, and (iii) interstitial Fe, probably due to the recoil imparted on the daughter57∗Fe nucleus in the β - decay of57Mn. In contrast to high fluence57Fe implantation studies the Fe3+ ions are found to prefer the tetrahedral Ga site over the octahedral Ga site. No annealing stages are evident in the temperature range investigated. Despite the very low concentration, high-spin Fe3+ shows fast spin relaxation, presumably due to an indirect interaction between nearby gadolinium atoms.

  19. Damping Proceedings Held in Las Vegas, Nevada on 5-7 March 1986. Volume 1

    Science.gov (United States)

    1986-05-01

    by qualitative judgement or by some regression technique. BASIC EQUATION The utilityf and economy of fractional calculus for complex modulus...Vibrations by Means of Viscoelastic Laminate," Section III of Structural Damping, ASME, pp. 49-88, 1959. 14. H. Oberst and K. Frankenfeld, " Uber die Dampfung...Vibrations by Means of Viscoelastic Laminate," Section III of Structural Damping, ASME, pp. 49-88, 1959. 14. H. Oberst and K. Frankenfeld, " Uber die

  20. Families of seven male-to-female transexuals after 5-7 years: Sociological sexology.

    Science.gov (United States)

    Money, J; Clarke, F; Mazur, T

    1975-03-01

    Four black and three whilte families have a male-to-female transexual member surgically reassigned more than 5 years ag. The black families were more open than the white in declaring the reassignment within the family and community. Thereby they relieved themselves and the transexual member of a need for deception, defiance, or defensiveness, and they were less scheming and manipulative. Without the anxiety of concealment, they could feel more positive about sex reassignment as a form of rehabilitation. A formal public declaration of sex reassignment, analogous to a declared change of citizenship, would be advantageous in transexual rehabilitation.

  1. (5,7-Dimethyl-2-oxo-2H-chromen-4-ylmethyl pyrrolidine-1-carbodithioate

    Directory of Open Access Journals (Sweden)

    N. M. Mahabaleshwaraiah

    2012-06-01

    Full Text Available In the title compound, C17H19NO2S2, the 2H-chromene ring system is almost planar, with a maximum deviation of 0.044 (2 Å, and the pyrrolidine ring adopts an envelope conformation. The dihedral angle between the 2H-chromene system and the planar part of the pyrrolidine ring is 83.65 (8°. A weak intramolecular C—H...S hydrogen bond occurs. The crystal structure features C—H...O hydrogen bonds and π–π interactions, with a centroid–centroid distance of 3.5728 (16 Å.

  2. Health Occupations Curriculum. Skills and Theory for Health Assistant. Volume 2, Units 5-7.

    Science.gov (United States)

    Arizona State Dept. of Education, Phoenix.

    This volume consists of three units of a basic core curriculum that is intended for all health workers. Covered in the units are the following topics: (1) the body's need for food, the effect of food on the body, the five food groups, the six nutrients, and therapeutic diets; (2) general principles of asepsis, specific methods of maintaining…

  3. Damping Proceedings Held in Las Vegas, Nevada on 5-7 March 1986. Volume 2

    Science.gov (United States)

    1986-05-01

    Balis Crema, A. Castellani, A. Nappi: "Influenza della Temperatura e del Vuoto sul coefficiente di Smorzamento in Giunti Rivettati", L’Atrotecnica...Vibrations Department of Ocean Engineering Florida Atlantic University Boca Raton, FL. 33431 ABSTRACT The total loss factor for coupled structures is...JOSEPH M. LOCKHEED-GA. CO. FLORIDA ATLANTIC UNIV. ZONE 406, DEPT 72-73 CENTER FOR ACOUSTICS & VIB.-DEPT. OCE 86 S. COBB DR. SMYRNA, GA. BOCA RATON, FL

  4. Report of the Regional ICM Workshop, Cox's Bazaar, Bangladesh, 5-7 December, 2011

    OpenAIRE

    2012-01-01

    Recommendations form the workshop included:establishment of "Pilot Sites"; trans-boundary ecosystem resource sharing;establishment of Marine Protected Areas(MPAs); joint research;promotion of co-management principles; preparation of a regional "coastal atlas" and development of a communications strategy

  5. Problems with the language development in children with Down syndrome aged 5-7 years

    Directory of Open Access Journals (Sweden)

    Mustaf Morina

    2016-07-01

    Full Text Available This study aims to explore and investigate the linguistic developments regarding children with Down syndrome. The study was conducted by interviewing children with Down syndrome. The study shows many problems with these children associated with difficulties with the reasoning attention, imitation, routines, and language development of children with Down syndrome, such as, speech problem, a problem related to pronunciation, sound or voice. This study uses the (Inductive and Qualitative primary research (deductive method with six case studies of children with Down syndrome, being induced on the Problems and difficulties of children with the Down syndrome in the field of language development.

  6. Crystal structure of 2-ethyl-3-(4-fluorophenylsulfonyl-5,7-dimethyl-1-benzofuran

    Directory of Open Access Journals (Sweden)

    Hong Dae Choi

    2014-10-01

    Full Text Available In the title compound, C18H17FO3S, the dihedral angle between the plane of the benzofuran ring [r.m.s. deviation = 0.006 (1 Å] and that of the 4-fluorophenyl ring [r.m.s. deviation = 0.004 (1 Å] is 82.45 (4°. In the crystal, molecules are linked via three different pairs of C—H...O hydrogen bonds, forming chains along [001] and enclosing two R22(10 and one R22(12 ring motifs. The chains are further linked by π–π interactions [inter-centroid distance = 3.566 (1 Å] between the furan rings of inversion-related molecules, forming a two-dimensional network lying parallel to (100.

  7. 3-(2-Fluorophenylsulfinyl-2,5,7-trimethyl-1-benzofuran

    Directory of Open Access Journals (Sweden)

    Hong Dae Choi

    2013-06-01

    Full Text Available In the title compound, C17H15FO2S, the benzofuran ring system, being essentially planar, with an r.m.s. deviation from the least-squares plane of 0.009 (2 Å, makes a dihedral angle of 79.02 (5° with the plane of the 2-fluorophenyl group. In the crystal, molecules are linked by pairs of weak C—H...O hydrogen bonds into centrosymmetric dimers.

  8. 2,5,7-Trimethyl-3-(4-methylphenylsulfonyl-1-benzofuran

    Directory of Open Access Journals (Sweden)

    Hong Dae Choi

    2012-06-01

    Full Text Available In the title compound, C18H18O3S, the 4-methylphenyl ring makes a dihedral angle of 86.35 (3° with the mean plane [mean deviation = 0.006 (1 Å] of the benzofuran fragment. In the crystal, molecules are linked by weak C—H...O and C—H...π interactions. The crystal structure also exhibits weak π–π interactions between the furan and benzene rings of neighbouring benzofuran systems [centroid–centroid distance = 3.685 (2, interplanar distance = 3.572 (2 and slippage = 0.906 (2 Å].

  9. Clontarf Private Nursing Home, 5 - 7 Clontarf Road, Clontarf, Dublin 3.

    LENUS (Irish Health Repository)

    O'Neill, J L

    2011-10-01

    Appropriate nutrition in pregnancy is fundamental for maternal and fetal health, and the long-term physiological wellbeing of the offspring. We aimed to determine whether a sample of pregnant women met the national guidelines for healthy eating during pregnancy, and to examine if compliance differs when analysed by Body Mass Index (BMI) category. Subjects completed a 24-hr dietary recall, and had their BMI calculated. The mean age was 27.8 years. The mean BMI was 25.1 kg\\/m2, with 32 (31.7%) subjects overweight and 14 (13.9%) obese based on BMI category. Although the majority of subjects thought that they had a healthy diet, less than half met the recommended guidelines for each individual food group with achievement of the dairy group being particularly low. Achievement of food group recommendations was not influenced by BMI category. Public health messages on healthy eating guidelines need to be clearly communicated to pregnant women.

  10. 29 CFR 5.7 - Reports to the Secretary of Labor.

    Science.gov (United States)

    2010-07-01

    ... disregarded its obligations to employees and subcontractors), and where restitution has been effected and... including any data on the amount of restitution paid, the number of workers who received restitution... reports. To assist the Secretary in fulfilling the responsibilities under Reorganization Plan No. 14 of...

  11. French Frigate Shoals Site P5 7/17/2001 36-37M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 36 and 37 meters along a permanent transect.

  12. French Frigate Shoals Site P5 7/17/2001 3-4M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 3 and 4 meters along a permanent transect.

  13. French Frigate Shoals Site P5 7/17/2001 28-29M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 28 and 29 meters along a permanent transect.

  14. French Frigate Shoals Site P5 7/17/2001 25-26M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 25 and 26 meters along a permanent transect.

  15. No overdensity of Lyman Alpha Emitting Galaxies around a quasar at z~5.7

    CERN Document Server

    Mazzucchelli, C; Decarli, R; Farina, E P; Venemans, B P; Walter, F; Overzier, R

    2016-01-01

    Bright quasars, observed when the Universe was less than one billion years old (z>5.5), are known to host massive black holes (~10$^{9}$ M$_{\\odot}$), and are thought to reside in the center of massive dark matter overdensities. In this picture, overdensities of galaxies are expected around high redshift quasars. However, observations based on the detection of Lyman Break Galaxies (LBGs) around these quasars do not offer a clear picture: this may be due to the uncertain redshift constraints of LBGs, which are selected through broad-band filters only. To circumvent such uncertainties, we here perform a search for Lyman Alpha Emitting galaxies (LAEs) in the field of the quasar PSO J215.1512-16.0417 at z~5.73, through narrow band, deep imaging with FORS2 at the VLT. We study an area of 37 arcmin$^{2}$, i.e. ~206 comoving Mpc$^{2}$ at the redshift of the quasar. We find no evidence for an overdensity of LAEs in the quasar field with respect to blank field studies. Possible explanations for these findings include ...

  16. 2-(5,7-Dimethoxy-4-oxo-4H-chromen-2-ylphenyl 4-toluenesulfonate

    Directory of Open Access Journals (Sweden)

    G. Ramachandran

    2008-08-01

    Full Text Available In the crystal structure of the title compound, C24H20O7S, the chromone system makes a dihedral angle of 37.32 (7° with the adjacent benzene ring. The chromone ring system and the tolyl ring are almost parallel, with a dihedral angle of 4.56 (9°. The tolyl ring is twisted at an angle of 41.75 (6° with respect to the benzene ring. Weak intra- and intermolecular C—H...O interactions are observed.

  17. French Frigate Shoals Site P5 7/17/2001 13-14M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 13 and 14 meters along a permanent transect.

  18. French Frigate Shoals Site P5 7/17/2001 26-27M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 26 and 27 meters along a permanent transect.

  19. French Frigate Shoals Site P5 7/17/2001 2-3M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 2 and 3 meters along a permanent transect.

  20. Proceedings of the Workshop on Low-Frequency Sound Sources, 5-7 November 1973

    Science.gov (United States)

    1974-09-01

    titanium multifilament wire. The disk will provide the driving force to two ,-opper coils rigidly attzched to moving pistons. Initial acoustic tests...PISTON SUPERCONDUCTOR (NIOBIUM TITANIUM MULTI FILAMENTS) THERMAL INSULATION LIQUID HELIUM COPPER (-450 F) WINDING High-Power 1 ranMducer Using...process involving heat and pressure. The steel parts were pickled and electroplated with copper and brass prior to bonding. All this involved more

  1. French Frigate Shoals Site P5 7/17/2001 8-9M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 8 and 9 meters along a permanent transect.

  2. French Frigate Shoals Site P5 7/17/2001 10-11M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 10 and 11 meters along a permanent transect.

  3. French Frigate Shoals Site P5 7/17/2001 40-41M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 40 and 41 meters along a permanent transect.

  4. French Frigate Shoals Site P5 7/17/2001 31-32M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 31 and 32 meters along a permanent transect.

  5. Padri e figlie: suggestioni ovidiane in una novella di Boccaccio (Decameron 5, 7)

    OpenAIRE

    Mario Labate

    2010-01-01

    Negli studi sul Decameron è consolidato un giudizio fortemente limitativo della rilevanza degli autori antichi, tra quelli che forniscono gli ipotesti delle singole novelle. Scopo di questo lavoro è mostrare, attraverso un esempio, come, nel quadro dei materiali letterari e narrativi che svolgono una funzione rilevante nel laboratorio dell’intertestualità decameroniana, la presenza della letteratura classica sia meno modesta di quanto sembrerebbe risultare dalla vulgata critica, e non si eser...

  6. Padri e figlie: suggestioni ovidiane in una novella di Boccaccio (Decameron 5, 7

    Directory of Open Access Journals (Sweden)

    Mario Labate

    2010-11-01

    Full Text Available Negli studi sul Decameron è consolidato un giudizio fortemente limitativo della rilevanza degli autori antichi, tra quelli che forniscono gli ipotesti delle singole novelle. Scopo di questo lavoro è mostrare, attraverso un esempio, come, nel quadro dei materiali letterari e narrativi che svolgono una funzione rilevante nel laboratorio dell’intertestualità decameroniana, la presenza della letteratura classica sia meno modesta di quanto sembrerebbe risultare dalla vulgata critica, e non si eserciti soltanto in maniera indiretta, o al livello di lontane matrici culturali o di archetipi di generi, di modalità o registri narrativi, ma possa anche proporsi come specifico rapporto tra testi. L’autore classico in questione è Ovidio, il testo una delle Heroides (precisamente la XI, Canace a Macareo, la novella in cui l’epistola ovidiana traspare in filigrana è Decameron V 7, a proposito della quale, secondo repertori e commenti, non sarebbero rintracciabili, al di là di singoli spunti e di un generico riferimento al tradizioni romanzesche, significative presenze di ‘fonti’ o ‘modelli’ riconoscibili. L’intertesto ovidiano, imponendosi sull’iniziale spunto romanzesco, orienta decisamente (anche se provvisoriamente la storia dei due giovani amanti verso una cupa tragedia, ponendo al centro della novella il contrasto tra un padre autoritario e la sua fragile figlia, vinta da una passione d’amore che le circostanze hanno reso irresistibile. Quando ormai la falsariga del modello ovidiano sembrerebbe destinata a condurre i protagonisti verso un destino di morte, l’improvviso riaffiorare del tema romanzesco (il fanciullo rapito e il gioco della fortuna conduce all’anagnorisis e a quell’insperato lieto fine che la regina ha imposto ai narratori come motivo-guida della giornata.

  7. Transfer and effects of 1,2,3,5,7-pentachloronaphthalene in an experimental food chain

    DEFF Research Database (Denmark)

    Slootweg, Tineke; Segner, Helmut; Mayer, Philipp

    2015-01-01

    CN52-induced expression of the phase I biotransformation enzyme gene cyp1a1 and the ABC transporter gene abcb1a. At the end of the 28-day study, biomagnification factors were similar for all dietary intake levels with values between 0.5 and 0.7kglipidfish/kg lipidworm. The average uptake efficiency...... of 60% indicated that a high amount of PeCN52 was transferred from the worms to the fish. Internal concentrations of up to 175mg/kg fish lipid in the highest treatment level did not result in effects on survival, behavior, or growth of the juvenile trout, but were associated with the induction of phase...

  8. Persuasive technology: 11th International Conference, PERSUASIVE 2016, Salzburg, Austria, April 5-7, 2016, Proceedings

    NARCIS (Netherlands)

    Meschtscherjakov, A.; Ruyter, B.E.R. de; Fuchsberger, V.; Murer, M.; Tscheligi, M.

    2016-01-01

    This book constitutes the refereed proceedings of the 11th International Conference on Persuasive Technology, PERSUASIVE 2016, held in Salzburg, Austria, in April 2016. The 27 revised full papers and 3 revised short papers presented were carefully reviewed and selected from 73 submissions. The paper

  9. French Frigate Shoals Site P5 7/17/2001 32-33M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at French Frigate Shoals, site P5 (23.880 N, 166.273 W), between 32 and 33 meters along a permanent transect.

  10. TASK 2.5.7 FIELD EXPERIMENTS TO EVALUATE COOL-COLORED ROOFING

    Energy Technology Data Exchange (ETDEWEB)

    Miller, William A [ORNL; Cherry, Nigel J [ORNL; Allen, Richard Lowell [ORNL; Childs, Phillip W [ORNL; Atchley, Jerald Allen [ORNL; Ronnen, Levinson [Lawrence Berkeley National Laboratory (LBNL); Akbari, Hashem [Lawrence Berkeley National Laboratory (LBNL); Berhahl, Paul [Lawrence Berkeley National Laboratory (LBNL)

    2010-03-01

    Aesthetically pleasing dark roofs can be formulated to reflect like a highly reflective white roof in the near infrared portion of the solar spectrum. New paint pigments increase the near infrared reflectance of exterior finishes by minimizing the absorption of near-infrared radiation (NIR). The boost in the NIR reflectance drops the surface temperatures of roofs and walls, which in turn reduces cooling-energy use and provides savings for the homeowner and relief for the utilities. In moderate and hot climates, a roof surface with high solar reflectance and high thermal emittance was shown by Akbari et al. (2004) and by Parker and Sherwin (1998) to reduce the exterior temperature and produce savings in comfort cooling. The new cool color pigments can potentially reduce emissions of carbon dioxide, which in turn reduces metropolitan heat buildup and urban smog. The pigments can also help conserve water resources otherwise used to clean and process fuel consumed by fossil-fuel driven power plants. Cool roofs also result in a lower ambient temperature that further decreases the need for air conditioning, retards smog formation, and improves thermal comfort. Parker, Sonne and Sherwin (2002) demonstrated that white barrel and white flat tiles reduced cooling energy consumption by 22% of the base load used by an adjacent and identical home having direct nailed dark shingles. Part of the savings was due to the reflectance of the white tiles; however, another part was due to the mass of the tile and to the venting occurring within the double batten installation. With, Cherry and Haig (2009) have studied the influence of the thermal mass and batten space ventilation and have found that, referenced to an asphalt shingle system, it can be equivalent to an additional 28 points of solar reflectivity. The double batten arrangement has wooden counter battens laid vertically (soffit-to-ridge) against the roof deck, and then the conventional battens are laid horizontally across the counter battens, providing a nailing surface for the concrete tile. This double batten construction forms an inclined air channel running from the soffit to the ridge. The bottom surface of the channel is formed by the roof decking and is relatively flat and smooth. The top surface is created by the underside of the roofing tiles, and is designed to be an air permeable covering to alleviate the underside air pressure and minimize wind uplift on the tiles. The resulting air flows also have a cooling influence which further complicates prediction of the heat penetrating through the deck because an accurate measure of the airflow is required to predict the heat transfer. Measured temperatures and heat flows at the roof surface, within the attic and at the ceiling of the houses are discussed as well as the power usage to help gauge the benefit of cool-pigmented reflective roof products fitted with and without ventilation above the roof deck. Ventilation occurring above the deck is an inherent feature for tile roof assemblies, and is formed by an air space between the exterior face of the roof sheathing and the underside of the tile. The greater the tile s profile the greater is the effect of the ventilation which herein is termed above-sheathing ventilation (ASV). However, because of the complexity of the thermally induced flow, little credit is allowed by state and federal building codes. ASHRAE (2005) provides empirical data for the effective thermal resistance of plane air spaces. A -in. (0.0191-m) plane air space inclined at 45 with the horizontal has an RUS-0.85 (RSI-0.15) . Our intent is to help further deploy cool color pigments in roofs by conducting field experiments to evaluate the new cool-colored roofing materials in the hot climate of Southern California. The collected data will be used to showcase and market the performance of new cool-roof products and also to help formulate and validate computer codes capable of calculating the heat transfer occurring within the attic and the whole building. Field measures and computer predictions showed that the demonstration home without a NIR-reflective tile coating and without above-sheathing ventilation had the greatest roof deck heat flow and subsequently the highest electrical usage. The house with both NIR paint pigments on the tile and with ASV had the least deck heat flows and therefore caused the home to consume the least amount of energy. The relative performance of the reflective coating and the ventilation individually is less obvious, but it is clear that the combination of a reflective tile with ASV is the preferred solution for the best energy saving.

  11. Intersociety Advanced Marine Vehicles Conference and Exhibit, Arlington, VA, June 5-7, 1989, Technical Papers

    Science.gov (United States)

    The present conference on advanced marine vehicles discusses advancements in surface-effect ship (SES) technologies, small waterplane-area twin-hull (SWATH) ship operations, advanced marine vehicle concepts, ocean systems and subsurface vehicles, air-cushion vehicle (ACV) concepts, seaplane technologies, advanced hull hydrodynamics, wing-in-ground effect (WIGE) aircraft, competition-craft aerodynamics, and marine propulsion. Attention is given to military applications of the 'NES 200' SES platform, experiences over 16 years of SWATH ship operations, hydrofoil catamarans for military and civilian applications, SES passenger ferries for the N.Y.C. metropolitan area, advanced submarine concepts, parametric studies in SWATH ship design, ACV experience in Antarctica, the CL-215 seaplane, large-scale WIGE vehicles, an ocean spacecraft-launch facility, an ACV Arctic icebreaker, and 'marinizing' methods for gas turbine engines.

  12. 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop: April 5-7, 2011

    Energy Technology Data Exchange (ETDEWEB)

    2011-10-01

    The U.S. marine energy industry is actively pursuing development of offshore wind and marine hydrokinetic (MHK) energy systems. Experience in the wind energy sector demonstrates that new technology development requires thorough measurement and characterization of the environmental conditions prevalent at installation sites and of technology operating in the field. Presently, there are no turn-key instrumentation system solutions that meet the measurement needs of the marine energy industry. The 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop brought together technical experts from government laboratories, academia, and industry representatives from marine energy, wind, offshore oil and gas, and instrumentation developers to present and discuss the instrumentation needs of the marine energy industry. The goals of the meeting were to: (1) Share the latest relevant knowledge among technical experts; (2) Review relevant state-of-the-art field measurement technologies and methods; (3) Review lessons learned from recent field deployments; (4) Identify synergies across different industries; (5) Identify gaps between existing and needed instrumentation capabilities; (6) Understand who are the leading experts; (7) Provide a forum where stakeholders from the marine energy industry could provide substantive input in the development of new marine energy field deployable instrumentation packages.

  13. Clontarf Private Nursing Home, 5 - 7 Clontarf Road, Clontarf, Dublin 3.

    LENUS (Irish Health Repository)

    Farrell, Eric

    2011-01-31

    Abstract Background Bone grafts are required to repair large bone defects after tumour resection or large trauma. The availability of patients\\' own bone tissue that can be used for these procedures is limited. Thus far bone tissue engineering has not lead to an implant which could be used as alternative in bone replacement surgery. This is mainly due to problems of vascularisation of the implanted tissues leading to core necrosis and implant failure. Recently it was discovered that embryonic stem cells can form bone via the endochondral pathway, thereby turning in-vitro created cartilage into bone in-vivo. In this study we investigated the potential of human adult mesenchymal stem cells to form bone via the endochondral pathway. Methods MSCs were cultured for 28 days in chondrogenic, osteogenic or control medium prior to implantation. To further optimise this process we induced mineralisation in the chondrogenic constructs before implantation by changing to osteogenic medium during the last 7 days of culture. Results After 8 weeks of subcutaneous implantation in mice, bone and bone marrow formation was observed in 8 of 9 constructs cultured in chondrogenic medium. No bone was observed in any samples cultured in osteogenic medium. Switch to osteogenic medium for 7 days prevented formation of bone in-vivo. Addition of β-glycerophosphate to chondrogenic medium during the last 7 days in culture induced mineralisation of the matrix and still enabled formation of bone and marrow in both human and rat MSC cultures. To determine whether bone was formed by the host or by the implanted tissue we used an immunocompetent transgenic rat model. Thereby we found that osteoblasts in the bone were almost entirely of host origin but the osteocytes are of both host and donor origin. Conclusions The preliminary data presented in this manuscript demonstrates that chondrogenic priming of MSCs leads to bone formation in vivo using both human and rat cells. Furthermore, addition of β-glycerophosphate to the chondrogenic medium did not hamper this process. Using transgenic animals we also demonstrated that both host and donor cells played a role in bone formation. In conclusion these data indicate that in-vitro chondrogenic differentiation of human MSCs could lead to an alternative and superior approach for bone tissue engineering.

  14. 3-[(E-2-(5,7-Dichloro-8-hydroxyquinolin-2-ylvinyl]-4-hydroxyphenyl acetate

    Directory of Open Access Journals (Sweden)

    2009-03-01

    Full Text Available The two symmetry independent molecules of the title compound, C19H13Cl2NO4, show similar conformations with the acetyl group twisted strongly relative to the remaining, virtually flat (r.m.s. deviations = 0.0173 and 0.0065 Å, part of the molecule. The hydroxyl groups of the 8-hydroxyquinoline residues are involved in intramolecular O—H...N hydrogen bonds, which, in one case, forms a part of a three-center interaction. Intermolecular O—H...O hydrogen bonds assemble the molecules into a one-dimensional polymeric structure extended along the a axis. The 4-hydroxyphenyl group of one molecule forms an O—H...O hydrogen bond, in which the hydroxyl H atom is disordered, with its inversion center counterpart.

  15. THE GALAXY ENVIRONMENT OF A QSO AT z {approx} 5.7

    Energy Technology Data Exchange (ETDEWEB)

    Banados, Eduardo; Venemans, Bram; Walter, Fabian [Max Planck Institut fuer Astronomie, Koenigstuhl 17, D-69117 Heidelberg (Germany); Kurk, Jaron [Max Planck Institut fuer Extraterrestrische Physik, Giessenbachstrasse, D-68165 Garching (Germany); Overzier, Roderik [Department of Astronomy, University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712-1205 (United States); Ouchi, Masami, E-mail: banados@mpia.de [Institute for Cosmic Ray Research, University of Tokyo, Kashiwa 277-8582 (Japan)

    2013-08-20

    High-redshift quasars are believed to reside in massive halos in the early universe and should therefore be located in fields with overdensities of galaxies, which are thought to evolve into galaxy clusters seen in the local universe. However, despite many efforts, the relationship between galaxy overdensities and z {approx} 6 quasars is ambiguous. This can possibly be attributed to the difficulty of finding galaxies with accurate redshifts in the vicinity of z {approx} 6 quasars. So far, overdensity searches around z {approx} 6 quasars have been based on studies of Lyman break galaxies (LBGs), which probe a redshift range of {Delta}z Almost-Equal-To 1. This range is large enough to select galaxies that may not be physically related to the quasar. We use deep narrow- and broadband imaging to study the environment of the z = 5.72 quasar ULAS J0203+0012. The redshift range probed by our narrow-band selection of Lyman alpha emitters (LAEs) is {Delta}z Almost-Equal-To 0.1, which is significantly narrower than the LBG searches. This is the first time that LAEs were searched for near a z {approx} 6 quasar, in an effort to provide clues about the environments of quasars at the end of the epoch of reionization. We find no enhancement of LAEs in the surroundings of ULAS J0203+0012 in comparison with blank fields. We explore different explanations and interpretations for this non-detection of a galaxy overdensity, including that (1) the strong ionization from the quasar may prevent galaxy formation in its immediate vicinity and (2) high-redshift quasars may not reside in the center of the most massive dark matter halos.

  16. Predictors of dental anxiety in Brazilian 5-7 years old children

    DEFF Research Database (Denmark)

    Soares, Fernanda Cunha; Lima, R. A.; Santos, Carolina da Franca Bandeira Ferreira

    2016-01-01

    Objectives: The aim of this study was to analyze the predictors of dental anxiety in 5 to 7-year-old children in a two years follow-up. Materials and methods: This is a longitudinal study conducted with 784 children with 5 to 7 years old. A face-to-face interview was conducted with the parents....... The Dental Anxiety Question (DAQ) answers were categorized as presence or absence of dental anxiety. The possible predictor factors analyzed were: related to the children (age, sex, parentage, childbirth, physical activity, body satisfaction, psychological well-being, physical well-being, dentist visit......); and related to the parents or guardians (excessive alcohol consumption, smoke, family income, number of children). Forward stepwise logistic binary regression was performed for the multivariate analysis. The analysis was controlled by gender. Results: The prevalence of dental anxiety was 17.4%. Children...

  17. [Языковые поездки EF

    Index Scriptorium Estoniae

    2009-01-01

    Rahvusvaheline koolitusorganisatsioon EF Education First korraldab keeleõpet välismaal. Populaarsemad Eestis pakutavad kursused on 13-18-aastastele noortele mõeldud suvised 3-4 nädalased keelereisid

  18. Välismaale keelt õppima / Anne Nelling

    Index Scriptorium Estoniae

    Nelling, Anne

    2009-01-01

    Rahvusvaheline koolitusorganisatsioon EF Education First korraldab keeleõpet välismaal. Populaarsemad Eestis pakutavad kursused on 13-18-aastastele noortele mõeldud suvised 3-4 nädalased keelereisid

  19. Omanäolised uuslavastused noortelt nukunäitlejatelt / Kati Kuusemets

    Index Scriptorium Estoniae

    Kuusemets, Kati

    2011-01-01

    Eesti Nuku- ja Noorsooteatri uutest lavastustest, Kadri Kalda lavastatud varjuteatrist „Rapuntsel” 4–10-aastastele ning maskiteatritehnikat kasutavast Mirko Rajase lavastusest Franz Kafka „Metamorfoos” gümnaasiumiealistele

  20. Multikultuur Sally Stuudios

    Index Scriptorium Estoniae

    2006-01-01

    Sally Stuudio avab uue multikultuurilise kunstistuudio 13-18 aastastele. Töökeeleks on inglise keel. Peale kunstitegemise pööratakse tähelepanu kultuurivahetusele ja erinevate kultuuride tundmaõppimisele

  1. Euroopa noortel nüüd oma portaal / Epp Adler ; interv. Sirje Tohver

    Index Scriptorium Estoniae

    Adler, Epp

    2004-01-01

    Avati 30 Euroopa riigis 15-25-aastastele mõeldud noorteportaal http://europa.eu.int/youth selle Eesti-poolne partner on Eurodesk Eesti/MTÜ Eesti Euroopa Liikumine. Vestlus Eurodesk Eesti projektijuhiga

  2. Idee noortefoorumilt - lõimiv tõsielusari / Kaarel Kressa

    Index Scriptorium Estoniae

    Kressa, Kaarel, 1983-

    2007-01-01

    Briti Nõukogu poolt Tallinnas kokku kutsutud noortefoorumist Network Effect, et mõttetalgute korras Eesti ühiskonna probleemidele lahendusi leida. Lõimumisteemalisest telemängust 16-aastastele eesti ja vene kooliõpilastele

  3. Euroopa noortel nüüd oma portaal / Epp Adler ; interv. Sirje Tohver

    Index Scriptorium Estoniae

    Adler, Epp

    2004-01-01

    Avati 30 Euroopa riigis 15-25-aastastele mõeldud noorteportaal http://europa.eu.int/youth selle Eesti-poolne partner on Eurodesk Eesti/MTÜ Eesti Euroopa Liikumine. Vestlus Eurodesk Eesti projektijuhiga

  4. [Языковые поездки EF

    Index Scriptorium Estoniae

    2009-01-01

    Rahvusvaheline koolitusorganisatsioon EF Education First korraldab keeleõpet välismaal. Populaarsemad Eestis pakutavad kursused on 13-18-aastastele noortele mõeldud suvised 3-4 nädalased keelereisid

  5. Välismaale keelt õppima / Anne Nelling

    Index Scriptorium Estoniae

    Nelling, Anne

    2009-01-01

    Rahvusvaheline koolitusorganisatsioon EF Education First korraldab keeleõpet välismaal. Populaarsemad Eestis pakutavad kursused on 13-18-aastastele noortele mõeldud suvised 3-4 nädalased keelereisid

  6. Draakonipuu seiklused / Krista Sunts

    Index Scriptorium Estoniae

    Sunts, Krista

    2007-01-01

    Kristel Lempu lasteraamatust "DINO. Draakonipuu seiklused" (Tallinn : Koolibri, 2007) sarjast "Logopeedilt lapsele". 4-7-aastastele lugemist alustavatele lastele. Soovitav ka nii lasteaedade kui ka koolide (1.-2. klass) lugemisraskustega õpilastele

  7. СПЕКТРОФОТОМЕТРИЧЕСКОЕ ОПРЕДЕЛЕНИЕ 5,7-БИС-(МЕТАНИТРОФЕНИЛАМИНО)-4,6-ДИНИТРОБЕНЗОФУРОКСАНА В ЛЕКАРСТВЕННЫХ ФОРМАХ

    OpenAIRE

    2013-01-01

    Исследованы электронные спектры растворов 5,7-бис-(метанитрофениламино)-4,6-динитробензофуроксана в ацетонитриле, диметилформамиде, диметилсульфоксиде и ацетоне. Разработана методика определения 5,7-бис-(метанитрофениламино)-4,6-динитробензофуроксана спектрофотометрическим методом в диметилсульфоксиде. Анализ экспериментальных данных доказал возможность использования этой методики для контроля качества субстанции 5,7-бис-(метанитрофениламино)-4,6-динитробензофуроксана и лекарственной формы на...

  8. A comparative study of 1,3,5-Trinitroperhydro-1,3,5-triazine (RDX) and Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) under high pressures using Raman spectroscopy and DFT calculations

    Science.gov (United States)

    Zeng, Yangyang; Song, Yunfei; Yu, Guoyang; Zheng, Xianxu; Guo, Wencan; Zhao, Jun; Yang, Yanqiang

    2016-09-01

    High pressure Raman experiment was performed to compare RDX and HMX crystals. Ab initio calculations using B3LYP Density Functional Theory method with Sadlej's medium-sized polarized basis set (SadlejpVTZ) were carried out for Caae RDX and 1,5-diaxial-3,7-diequatorial chair HMX molecules. Our calculations and measured Raman vibrational spectra reveal both molecules have similarities on bonding and vibrational properties at ambient pressure. However, high pressure responses for both molecules aren't the same. For RDX, at pressure near 4 GPa, a number of changes become apparent in the Raman spectra, such as modes splitting, intensity modification, and discontinuity of pressure-dependence of frequency shifts, which are consistent with previous experiment and believed to associate with α-γ phase transition. For HMX, only slight conformational deformation involving NO2 group was observed, and was considered as an onset of β-ε phase transition. It is proposed that the markedly different behavior under high pressure for these two molecules results from different molecular packing in unit cell.

  9. STEREO and Wind observations of a fast ICME flank triggering a prolonged geomagnetic storm on 5-7 April 2010

    CERN Document Server

    Möstl, Christian; Rollett, Tanja; Farrugia, Charles J; Liu, Ying; Veronig, Astrid M; Leitner, M; Galvin, Antoinette B; Biernat, Helfried K

    2010-01-01

    On 5 April 2010 an interplanetary (IP) shock was detected by the Wind spacecraft ahead of Earth, followed by a fast (average speed 650 km/s) IP coronal mass ejection (ICME). During the subsequent moderate geomagnetic storm (minimum Dst = -72 nT, maximum Kp=8-), communication with the Galaxy 15 satellite was lost. We link images from STEREO/SECCHI to the near-Earth in situ observations and show that the ICME did not decelerate much between Sun and Earth. The ICME flank was responsible for a long storm growth phase. This type of glancing collision was for the first time directly observed with the STEREO Heliospheric Imagers. The magnetic cloud (MC) inside the ICME cannot be modeled with approaches assuming an invariant direction. These observations confirm the hypotheses that parts of ICMEs classified as (1) long-duration MCs or (2) magnetic-cloud-like (MCL) structures can be a consequence of a spacecraft trajectory through the ICME flank.

  10. Secret of Lake Phelps. Pettigrew State Park: An Environmental Education Learning Experience Designed for Grades 5-7.

    Science.gov (United States)

    Woods, Martha P.

    This activity guide, developed to provide hands-on environmental education activities geared to Pettigrew State Park in North Carolina, is targeted for grades 5, 6, and 7 and meets curriculum objectives of the standard course of study established by the North Carolina Department of Public Instruction. Three types of activities are included:…

  11. Role of magnetic fields in physics and astrophysics; Proceedings of the Conference, Copenhagen, Denmark, June 5-7, 1974

    Science.gov (United States)

    Canuto, V.

    1975-01-01

    The papers deal with the role of magnetism in astrophysics and the properties of matter in the presence of unusually large magnetic fields. Topics include a quantum-mechanical treatment of high-energy charged particles radiating in a homogeneous magnetic field, the solution and properties of the Dirac equation for magnetic fields of any strength up to 10 to the 13th power gauss, experimental difficulties encountered and overcome in generating megagauss fields, the effect of strong radiation damping for an ultrarelativistic charge in an external electromagnetic field, magnetic susceptibilities of nuclei and elementary particles, and Compton scattering in strong external electromagnetic fields. Other papers examine static uniform electric and magnetic polarizabilities of the vacuum in arbitrarily strong magnetic fields, quantum-mechanical processes in neutron stars, basic ideas of mean-field magnetohydrodynamics, helical MHD turbulence, relations between cosmic and laboratory plasma physics, and insights into the nature of magnetism provided by relativity and cosmology. Individual items are announced in this issue.

  12. Shielding calculations for industrial 5/7.5MeV electron accelerators using the MCNP Monte Carlo Code

    Science.gov (United States)

    Peri, Eyal; Orion, Itzhak

    2017-09-01

    High energy X-rays from accelerators are used to irradiate food ingredients to prevent growth and development of unwanted biological organisms in food, and by that extend the shelf life of the products. The production of X-rays is done by accelerating 5 MeV electrons and bombarding them into a heavy target (high Z). Since 2004, the FDA has approved using 7.5 MeV energy, providing higher production rates with lower treatments costs. In this study we calculated all the essential data needed for a straightforward concrete shielding design of typical food accelerator rooms. The following evaluation is done using the MCNP Monte Carlo code system: (1) Angular dependence (0-180°) of photon dose rate for 5 MeV and 7.5 MeV electron beams bombarding iron, aluminum, gold, tantalum, and tungsten targets. (2) Angular dependence (0-180°) spectral distribution simulations of bremsstrahlung for gold, tantalum, and tungsten bombarded by 5 MeV and 7.5 MeV electron beams. (3) Concrete attenuation calculations in several photon emission angles for the 5 MeV and 7.5 MeV electron beams bombarding a tantalum target. Based on the simulation, we calculated the expected increase in dose rate for facilities intending to increase the energy from 5 MeV to 7.5 MeV, and the concrete width needed to be added in order to keep the existing dose rate unchanged.

  13. CONARC Training Workshop, Fort Gordon, Georgia, 5-7 October 1971. Volume V. Methods and Media Specialty Workshop.

    Science.gov (United States)

    1971-10-01

    The medium is the final physical delivery system. Just to amplify it a little bit- -some media, as Marshall McLuhan has pointed out--are media within...sorts of media within media questions and Marshall McLuhan practically pointed out V-95 ( i I I I . . - . . that the only pure medium is light, that

  14. Cable Television and the Performing Arts. The Proceedings of a Conference (New York, New York, June 5-7, 1981).

    Science.gov (United States)

    New York Univ., NY. School of the Arts.

    Included in this set of proceedings are a keynote address on the state of the art of cable television and the future of the television economy by Les Brown, editor-in-chief of "Channels" magazine; panel discussions on the structure of the cable television industry; the potential market for cable television arts programming; the birth and…

  15. Fiber optic and laser sensors VII; Proceedings of the Meeting, Boston, MA, Sept. 5-7, 1989

    Science.gov (United States)

    Udd, Eric (Editor); Depaula, Ramon P. (Editor)

    1990-01-01

    Various papers on fiber optic and laser sensors are presented. Individual topics addressed include: fiber optic photoelastic pressure sensor for high-temperature gases, fiber optic gyroscope using an eight-component LiNbO3 integrated optic circuit, design and performance of a fiber optic gyroscope using integrated optics, digital angular position sensor using wavelength division multiplexing, simple repeatable fiber optic intensity sensor for temperature measurement, compensation for effects of ambient temperature on rare-earth-doped fiber optic thermometer.

  16. Proceedings of the American Towing Tank Conference (21st) Held in Washington, DC. on 5-7th August 1986,

    Science.gov (United States)

    1987-08-01

    Systems Control Technology, Inc. 1801 Page Mill Road Palo Alto , California 94304 USA ABSTRACT r yaw rate r’ dimensionless yaw rate: r.f/ur The Marine...1955 TUG 30 5.0 1.6 b ,’i Escuela Tecnica Superior de 1967 E T S’,.’ ,:: Ingienieros Navales, Madrid ,nd a second relationship for tank a . rs 6

  17. Assessment and Accountability in Higher Education. Proceedings Document (Sante Fe, New Mexico, December 5-7, 1989). ECS Working Papers.

    Science.gov (United States)

    Education Commission of the States, Denver, CO.

    The conference reported in this document was attended by representatives of seven states (Florida, Illinois, New Jersey, New Mexico, Tennessee, Virginia, and Washington). Participants focused on three key questions: (1) what are the issues and objectives behind assessment in each state? (2) what can be done regarding the implementation of…

  18. The Association between Prenatal Psychosocial Stress and Blood Pressure in the Child at Age 5-7 Years

    OpenAIRE

    2012-01-01

    OBJECTIVE: Prenatal maternal stress could have permanent effects on the offspring's tissue structure and function, which may predispose to cardiovascular diseases. We investigated whether maternal psychosocial stress is a prenatal factor affecting the blood pressure (BP) of offspring. STUDY DESIGN: In the Amsterdam Born Children and their Development (ABCD) study, around gestational week 16, depressive symptoms, state-anxiety, pregnancy-related anxiety, parenting daily hassles and job strain ...

  19. Teachers' Reporting of Behavioural Problems and Cognitive-Academic Performances in Children Aged 5-7 Years

    Science.gov (United States)

    Giannopulu, I.; Escolano, S.; Cusin, F.; Citeau, H.; Dellatolas, G.

    2008-01-01

    Background: The behavioural and academic performance of young children with teachers' reported hyperactivity, conduct problems or inattention is under debate. Aim: This study investigates the associations between teachers' reported behavioural difficulties and academic and cognitive performances in two large samples of preschool and school…

  20. Crystal structure of (S-5,7-diphenyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine

    Directory of Open Access Journals (Sweden)

    Ivy K. Price

    2015-04-01

    Full Text Available The title compound, C16H13N5, was synthesized by coupling aminotetrazole with chalcone in the presence of an amine organocatalyst derived from chincona alkaloid. There are two molecules, A and B, in the asymmetric unit. In molecule A, the dihedral angles between the partly hydrogenated pyrimidine ring system (r.m.s. deviation = 0.056 Å and the sp2- and sp3-bonded phenyl groups are 33.32 (11 and 86.53 (11°, respectively. The equivalent data for molecule B are 0.049 Å, and 27.05 (10 and 85.27 (11°, respectively. In the crystal, A+B dimers linked by pairs of N—H...N hydrogen bonds generate R22(8 loops. The dimers are linked by aromatic π–π stacking interactions [shortest centroid–centroid separation = 3.5367 (15 Å], which results in a three-dimensional network.

  1. Proceedings of the Space Surveillance Workshop (12th) Held in Lexington, Massachusetts on 5-7 April 1994. Volume 2

    Science.gov (United States)

    1994-04-07

    Plane Unit Focal Plane Unit Filtr Wheel WFOV Ultraviolet Primary Mirror Tertiary Mirror SunshadeF•4 -A FocalPlnI Secondary Unit Filktr Wheel Mirror I...from UVISI pixel coordinates to spacecraft coordinates and passes them to the MSX flight processor, which performs Kalman filtering of other...to follow the target through extended data dropouts. A second method, the extended Kalman filter, bases its state propagation on underlying equations

  2. Temporal Management of the Writing Process: Effects of Genre and Organizing Constraints in Grades 5, 7, and 9

    Science.gov (United States)

    Beauvais, Lucie; Favart, Monik; Passerault, Jean-Michel; Beauvais, Caroline

    2014-01-01

    We investigated changes across grades in the cognitive demands associated with the organizing subprocess of writing. A total of 85 fifth (age M = 10.8), 88 seventh (age M = 12.9), and 79 ninth (age M = 14.6) graders composed either a procedural text or an expository description on a digital tablet, on the basis of a "scrambled ideas"…

  3. Cable Television and the Performing Arts. The Proceedings of a Conference (New York, New York, June 5-7, 1981).

    Science.gov (United States)

    New York Univ., NY. School of the Arts.

    Included in this set of proceedings are a keynote address on the state of the art of cable television and the future of the television economy by Les Brown, editor-in-chief of "Channels" magazine; panel discussions on the structure of the cable television industry; the potential market for cable television arts programming; the birth and…

  4. Water-quality conditions during low flow in the lower Youghiogheny River basin, Pennsylvania, October 5-7, 1998

    Science.gov (United States)

    Sams, J. I.; Schroeder, K.T.; Ackman, T.E.; Crawford, J.K.; Otto, K.L.

    2001-01-01

    In October 1998, a chemical synoptic survey was conducted by the U.S. Geological Survey, in cooperation with the U.S. Department of Energy, National Energy Technology Laboratory, in the Lower Youghiogheny River Basin in Pennsylvania to give a snapshot of present (1998) water quality during low-flow conditions. Water samples from 38 sites?12 mainstem sites, 22 tributaries, and 4 mine discharges that discharge directly to the Youghiogheny River?were used to identify sources of contaminants from mining operations. Specific conductance, water temperature, pH, and dissolved oxygen were measured in the field at each site and concentrations of major ions and trace elements were measured in the laboratory. Unaccounted for gains and losses in streamflow were measured during the study. Unaccounted for losses in streamflow might be attributed to water loss through streambed fractures. Extensive mine tunnels are present in the basin and loss of water to these tunnels seems likely. Unaccounted for gains in streamflow may be from unmeasured tributaries or surface seeps, but most of the gains are suspected to come from artesian flow through fractures in the streambed from underground mine pools. Influent flows of rust-colored water were noted in some river sections. The pH values for all the samples collected during this survey were above 5.8, and most (33 of 38 samples) were above 7.0. Samples from the four minedischarge sites also had pH values between 6.3 and 6.7. The lowest pH (5.8) was in a tributary, Galley Run. All 38 sampling sites had net alkalinity. The alkalinity load in the Youghiogheny River increased between Connellsville and McKeesport from 35 to 79 tons per day. Above Smithton, the measured alkalinity load in the Lower Youghiogheny River agreed well with the estimated alkalinity load. Below Smithton, measured alkalinity loads in the Lower Youghiogheny River are greater than calculated loads, resulting in unaccounted for gains in alkalinity. These gains are believed to be from seeps in the streambed. Approximately one-third of the load of total alkalinity in the Youghiogheny River at McKeesport is attributed to Sewickley Creek, which contri-butes 14 tons per day. Sulfate concentrations in the Youghiogheny River steadily increase from 33 milligrams per liter at Connellsville to 77 milligrams per liter near McKeesport. The measured concentrations of sulfate exceeded Pennsylvania water-quality standards at four tributary sites (Galley Run, Hickman Run, Sewickley Creek, and Gillespie Run) and all four mine-discharge sites but not at any main-stem sites. A large increase in sulfate load between West Newton and Sutersville can be attributed almost entirely to the contribution from Sewickley Creek (49 tons per day). Approximately 25 percent of the load measured between Connellsville and McKeesport is unaccounted for. These gains are believed to be from seeps in the streambed from underground mine pools. Similar patterns also were observed for loads of sodium, calcium, and magnesium. Unmeasured inputs from mine drainage are believed to be the source of these loads. Elevated concentrations (above background levels) of chemicals associated with drainage from coal-mining operations were measured in samples from tributaries, especially from Galley Run, Gillespie Run, and Sewickley Creek, and from the mine-discharge sites. The synoptic survey conducted for this study was successful in identifying generalized reaches of the Youghiogheny River where unaccounted for loads of constituents associated with mining activities are entering the river. However, the survey was not able to pinpoint the location of these loads. Remote-sensing techniques, such as thermal infrared imaging by the National Energy Technology Laboratory, could be useful for determining the precise locations of these inputs.

  5. SPT0346-52: Negligible AGN Activity in a Compact, Hyper-starburst Galaxy at z = 5.7

    CERN Document Server

    Ma, Jingzhe; Vieira, J D; Aravena, M; Ashby, M L N; Bethermin, M; Bothwell, M S; Brandt, W N; de Breuck, C; Carlstrom, J E; Chapman, S C; Gullberg, B; Hezaveh, Y; Litke, K; Malkan, M; Marrone, D P; McDonald, M; Murphy, E J; Spilker, J S; Sreevani, J; Stark, A A; Strandet, M; Wang, S X

    2016-01-01

    We present Chandra ACIS-S and ATCA radio continuum observations of the strongly lensed dusty, star-forming galaxy SPT-S J034640-5204.9 (hereafter SPT0346-52) at $z$ = 5.656. This galaxy has also been observed with ALMA, HST, Spitzer, Herschel, APEX, and the VLT. Previous observations indicate that if the infrared (IR) emission is driven by star formation, then the inferred lensing-corrected star formation rate ($\\sim$ 4500 $M_{\\sun}$ yr$^{-1}$) and star formation rate surface density $\\Sigma_{\\rm SFR}$ ($\\sim$ 2000 $M_{\\sun} {yr^{-1}} {kpc^{-2}}$) are both exceptionally high. It remained unclear from the previous data, however, whether a central active galactic nucleus (AGN) contributes appreciably to the IR luminosity. The {\\it Chandra} upper limit shows that SPT0346-52 is consistent with being star-formation dominated in the X-ray, and any AGN contribution to the IR emission is negligible. The ATCA radio continuum upper limits are also consistent with the FIR-to-radio correlation for star-forming galaxies w...

  6. ASTPHLD Annual Conference on Human Retrovirus Testing (6th) Held in Kansas City, Missouri on March 5 - 7, 1991

    Science.gov (United States)

    1992-01-31

    laboratory should evaluate the need to establish flow cytometry capability based on an assessment of criteria including: prevalence of HIV infection and...patients or individuals in which EIA false positive reactions are common (patients infected with syphilis, legionella. brucella , Epstein Barr virus...30 min at 40°C, washed three times with 5 ml of distilled H20, and incubated with goat anti-hu- man IgG, conjugated with horseradish peroxidase. for

  7. Stellar Activity on the Young Suns of Orion: COUP Observations of K5-7 Pre-Main Sequence Stars

    CERN Document Server

    Wolk, S J; Micela, G; Favata, F; Glassgold, A E; Shang, H; Feigelson, E D

    2005-01-01

    In January 2003, the Chandra Orion Ultradeep Project (COUP) detected about 1400 young stars during a 13.2 day observation of the Orion Nebula Cluster (ONC). This paper studies a well-defined sample of 28 solar-mass COUP sources to characterize the magnetic activity of analogs of the young Sun and thereby to improve understanding of the effects of solar X-rays on the solar nebula during the era of planet formation. We find that active young Suns spend 70% of their time in a characteristic state with relatively constant flux and magnetically confined plasma with temperatures kT_2 = 2.1 * kT_1. During characteristic periods, the 0.5-8 keV X-ray luminosity is about 0.03% of the bolometric luminosity. One or two powerful flares per week with peak luminosities logL_x ~ 30-32 erg/s are typically superposed on this characteristic emission accompanied by heating of the hot plasma component from ~2.4 keV to ~7 keV at the flare peak. The energy distribution of flares superposed on the characteristic emission level follo...

  8. Dicarbonyl(hexamethylene-1,3,5,7-tetramine-κN1(η5-pentamethylcyclopentadienyliron(II tetrafluoridoborate

    Directory of Open Access Journals (Sweden)

    Cyprian M. M'thiruaine

    2012-07-01

    Full Text Available In the title compound, [Fe(C10H15(C6H12N4(CO2]BF4, the arrangement around the FeII atom corresponds to a three-legged piano stool. The pentamethylcyclopentadienyl (Cp* ligand occupies three coordination sites, while two CO ligands and one N atom of the hexamethylenetetramine ligand occupy the remaining coordination sites, completing a pseudo-octahedral geometry. Both the complex cation and the BF4− anion reside on crystallographic mirror planes. The Fe—N bond length is 2.069 (2 and the Fe—Cp*(centroid distance is 1.7452 (3 Å.

  9. Relationship between obesity and leptin serum among low socioeconomic primary school children aged 5-7 years

    Directory of Open Access Journals (Sweden)

    Soenarto Soenarto

    2010-06-01

    Full Text Available Background Obesity has become a major health problem globally, indicates as an epidemic problem by World Health Organization (WHO. Adiposity rebound period may represent critical period for the development of adiposity. Recent data suggest that, in industrialized countries, people of low socioeconomic group are more likely to be obese than their high socioeconomic counterparts. Level of serum leptin was reported to be higher in obese subjects. There has been lack of data regarding leptin serum level in Indonesian obese children. Objective This study aimed to investigate leptin serum level in low socioeconomic obese children.  Methods This was a cross sectional study perfonned in Tuminting District, Manado. Obesity was defined based on body mass index for AsiaPacific condition, i.e., grade I obesity (BMI 25/29.9 kg/ mL, grade II (BM] 30-40 kg/ml, and grade III (BM] > 40 kg/m2 Low socioeconomic status was detennined based on Government's program Cash Direct Aid Program. loBod sample was obtained from inclusion subjects, consisted of leptin serum. Results Fiftytwo low socioeconomic obese children were eligible \\\\lith age ranged between 5 to 7 years. They were divided into grade ] obesity (43 or 82.7%, and grade II (9 or 17.3%. The lowest leptin blood level was 10,291 pg/mL, while the highest was 41,500 pg/dL. All girls had nonnal serum leptin level; in contrast all boys had increased serum leptin level.  Conclusions Leprin level increased in those subjects whose BMI increased.

  10. Temporal Management of the Writing Process: Effects of Genre and Organizing Constraints in Grades 5, 7, and 9

    Science.gov (United States)

    Beauvais, Lucie; Favart, Monik; Passerault, Jean-Michel; Beauvais, Caroline

    2014-01-01

    We investigated changes across grades in the cognitive demands associated with the organizing subprocess of writing. A total of 85 fifth (age M = 10.8), 88 seventh (age M = 12.9), and 79 ninth (age M = 14.6) graders composed either a procedural text or an expository description on a digital tablet, on the basis of a "scrambled ideas"…

  11. CONARC Training Workshop, Fort Gordon, Georgia, 5-7 October 1971. Volume III. Educational Television and Training Films Specialty Workshop.

    Science.gov (United States)

    1971-10-01

    the skip field, is very saving on tape material and allows us to use a very conventional video iron oxide tape which reduces video headwear . Similarly...The headwear is also minimized since during the fast winding, rewind, there is no head contact. The termination is three door, in what you saw

  12. Proceedings of the 1989 Structural Integrity Program Conference Held in San Antonio, Texas on 5-7 Dec 1989

    Science.gov (United States)

    1990-04-01

    ASD/ENF 0800-0830 A Procedure for Separation of Gust and Maneuver Loads Dr F. Eichenbaum and J. W. Chapman - Lockheed Aeronautical Systems Company D...Systems Research Laboratory Ward Rummel Martin Marietta / Denver Lindy Shambaugh Pratt & Whitney / Florida Bob Stone San Antonio-A LC/MMFR Sharon Vukelich

  13. Building Creativity Training: Drawing with Left Hand to Stimulate Left Brain in Children Age 5-7 Years Old

    Science.gov (United States)

    Saputra, Yanty Hardi; Sabana, Setiawan

    2016-01-01

    Researcher and professionals that started researching about brains since 1930 believe that left brain is a rational brain, which is tightly related with the IO, rational thinking, arithmetic thinking, verbal, segmental, focus, serial (linear), finding the differences, and time management, Meanwhile right brain is the part of brain that controlled…

  14. Just Film otsib kriitikuid / Merlyn Uusküla

    Index Scriptorium Estoniae

    Uusküla, Merlyn

    2007-01-01

    11. PÖFFi laste-ja noortefilmide festival Just Film korraldas oma juhi Elen Lotmani eestvõttel 12-18-aastastele noortele filmiarvustuste kirjutamise konkursi, mille parimad saavad arvustada Just Filmi filme ka ajakirjanduses. Lisatud Just Filmi žüriidesse kuuluvate laste ja noorte nimekirjad

  15. Keskraamatukogu kutsub Mozartit joonistama

    Index Scriptorium Estoniae

    2006-01-01

    Keskraamatukogu kuulutas välja Wolfgang Amadeus Mozarti 250. sünniaastapäevale pühendatud joonistusvõistluse 7-19-aastastele Tallinna ja Harjumaa noortele (tööde viimane postitamise või kohaletoomise kuupäev on 2. mai, info: www.tln.lib.ee)

  16. Joonistada, et õppida armastama / Anneli Sihvart

    Index Scriptorium Estoniae

    Sihvart, Anneli, 1964-

    2011-01-01

    Konkursi algataja Marina Tee 3-17-aastastele mõeldud rahvusvahelisest loomekonkursist "Maa värvid". Seekordne, 12. konkurss teemal "Minu kodulinn" või "Merelinn Tallinn" toimub Euroopa kultuuripealinna Tallinn 2011 raames. Joonistamise mõjust lapse arengule

  17. Poolakate kiirmoe kaubamärk püüab rohkem keskmist inimest / Liis Kängsepp

    Index Scriptorium Estoniae

    Kängsepp, Liis, 1981-

    2004-01-01

    20-25 aastastele noortele suunatud kiirmoe kontseptsiooni esindavate kaubamärkide Monton ja Reserved konkurentsist Tallinna kaubanduskeskustes. Vt. samas: Reserved murdis kiiresti kasumisse; Montoni Eesti päritolu annab koduturul eelise. Lisad: Kaubamärk Monton; Kaubamärk Reserved. Diagramm: LPP Retail Estonia käive tegi mullu hüppe

  18. Joonistada, et õppida armastama / Anneli Sihvart

    Index Scriptorium Estoniae

    Sihvart, Anneli, 1964-

    2011-01-01

    Konkursi algataja Marina Tee 3-17-aastastele mõeldud rahvusvahelisest loomekonkursist "Maa värvid". Seekordne, 12. konkurss teemal "Minu kodulinn" või "Merelinn Tallinn" toimub Euroopa kultuuripealinna Tallinn 2011 raames. Joonistamise mõjust lapse arengule

  19. U nih bolshe vremeni dlja sebja, i oni stanovjatsja krassavitsami

    Index Scriptorium Estoniae

    2005-01-01

    Financial Times uuringu andmetel on eeldused kõige kaunimad välja näha ja elada täisväärtuslikku elu, praegustel läänemaailma 40. aastastel naistel. Ka ameerika menuseriaalist "Desperate Housewives"

  20. Rahvusvaheline kunstikonkurss "Arvud ja numbrid ئ universaalne keel"

    Index Scriptorium Estoniae

    1999-01-01

    Louis Franȯis nimeline UNESCO keskus Prantsusmaal Troyes' korraldab visuaalkunstikonkursi "Üks, kaks, kolm... arvud ja numbrid, universaalne keel" 3 - 25-aastastele lastele ja noortele. Töid võib esitada mistahes vallas. Info konkursi kohta. Tähtaeg 15. märts 1999.

  1. Märjamaa rahvamajja "Noorsoolikale". Linnalaager tutvustab muusikastiile

    Index Scriptorium Estoniae

    2006-01-01

    Alternatiivmuusika- ja kunstipeost "Noorsoolikas 2006" 17. juunil Märjamaa rahvamajas (info: www.noorsoolikas.ee). Popmuusikastiile tutvustavast linnalaagrist "Tunne oma stiili" 10-13-aastastele lastele 31. juulist 4. augustini Haabersti avatud noortekeskuses (Õismäe tee 88A)

  2. Märjamaa rahvamajja "Noorsoolikale". Linnalaager tutvustab muusikastiile

    Index Scriptorium Estoniae

    2006-01-01

    Alternatiivmuusika- ja kunstipeost "Noorsoolikas 2006" 17. juunil Märjamaa rahvamajas (info: www.noorsoolikas.ee). Popmuusikastiile tutvustavast linnalaagrist "Tunne oma stiili" 10-13-aastastele lastele 31. juulist 4. augustini Haabersti avatud noortekeskuses (Õismäe tee 88A)

  3. U nih bolshe vremeni dlja sebja, i oni stanovjatsja krassavitsami

    Index Scriptorium Estoniae

    2005-01-01

    Financial Times uuringu andmetel on eeldused kõige kaunimad välja näha ja elada täisväärtuslikku elu, praegustel läänemaailma 40. aastastel naistel. Ka ameerika menuseriaalist "Desperate Housewives"

  4. Üksikemade pered - üks riskigruppidest / Niina Derman

    Index Scriptorium Estoniae

    Derman, Niina

    2001-01-01

    Artiklis keskendutakse 18-49-aastastele alaealisi lapsi üksinda kasvatavatele naistele ja nende toimetulekuprobleemidele. Võrdlusgruppidena on uurimusse kaasatud samas vanuses ilma lasteta naised ning alaealiste lastega (vaba)abielus naised. Artikkel põhineb elanikkonnaküsitluse "Eesti 98" andmetel

  5. Swift reveals a ~5.7 day super-orbital period in the M31 globular cluster X-ray binary XB158

    CERN Document Server

    Barnard, R; Murrray, S S

    2015-01-01

    The M31 globular cluster X-ray binary XB158 (a.k.a. Bo 158) exhibits intensity dips on a 2.78 hr period in some observations, but not others. The short period suggests a low mass ratio, and an asymmetric, precessing disk due to additional tidal torques from the donor star since the disk crosses the 3:1 resonance. Previous theoretical 3D smoothed particle hydrodynamical modeling suggested a super-orbital disk precession period 29$\\pm$1 times the orbital period, i.e. $\\sim$81$\\pm$3 hr. We conducted a Swift monitoring campaign of 30 observations over ~1 month in order to search for evidence of such a super-orbital period. Fitting the 0.3--10 keV Swift XRT luminosity lightcurve with a sinusoid yielded a period of 5.65+/-0.05 days, and a >5$\\sigma$ improvement in $\\chi^2$ over the best fit constant intensity model. A Lomb-Scargle periodogram revealed that periods 5.4--5.8 days were detected at a >3$\\sigma$ level, with a peak at 5.6 days. We consider this strong evidence for a 5.65 day super-orbital period, ~70\\% l...

  6. Interagency Symposium on University Research in Transportation Noise (2nd) Held at North Carolina State University, Raleigh on June 5-7, 1974. Book of Proceedings, Volume 2

    Science.gov (United States)

    1974-06-01

    reflections, etc. ii. in basic studies of outdoor sound propagation, in support of scale model and field experiments, and iii. in exploring the...These pinpointed the nemo for care in the neighborhood of zeros of the input power spectrum. Use of a smoothing operation on the input and output...collection program: 1. In-train, short runs will be made on all car types on each signi- ficant tunnel or outdoor configuration so that the total

  7. Heavy-duty engine testing report-correlation testing of GMC (General Motors Corporation) 5. 7l/MVMA engine. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    Jones, L.

    1988-06-01

    The correlation between the heavy-duty test facilities of a manufacturer and the Environmental Protection Agency Motor Vehicle Emission Laboratory (MVEL) is of significant interest to both the manufacturer and EPA. It is especially important from a regulatory standpoint because of Selective Enforcement Audit (SEA) testing requirements. Thus, EPA/MVEL conducted testing on a Chevrolet heavy-duty gasoline-fueled engine with the intent of providing correlation data for comparison with similar data developed by laboratories which conduct SEA emissions tests for the manufacturers of heavy-duty gasoline (HDG) engines. The round-robin program was a joint effort on the part of EPA/MVEL and the Motor Vehicle Manufacturers Association (MVMA).

  8. What Do the Children Really Think about a Day-Care Centre--The 5-7-Year-Old Finnish Children Speak out

    Science.gov (United States)

    Kyronlampi-Kylmanen, Taina; Maatta, Kaarina

    2012-01-01

    A day-care centre is a place where a child spends most of his/her week nowadays. A day-care centre as an institution of early childhood education has often been studied from the early childhood educators' point of view or within a wider societal context. The children's voices have not been heard much. The purpose of this article is to describe, on…

  9. The Role of Eddies in the General Ocean Circulation: Proceedings of ’Aha Huliko’a Hawaiian Winter Workshop Held at Manoa on January 5-7, 1983

    Science.gov (United States)

    1983-01-01

    in Topics in Ocean Physics, Proc. Summer Sch 1980 A. Osborne and P.M. Rizzoli, eds, Soc. Italiana di Fisica , Bologna (Elsevier, NY). Also available...from Table 1. 217 HEAT The mean heat balance equation in the interior can be written ae (’’) az 8 u.v8 + w - . - (w’’) , (17) neglecting molecular ...the general circulation? McWilliams: I challenge you to construct a general circulation model using only molecular diffusion. Muller: What happened

  10. What Do the Children Really Think about a Day-Care Centre--The 5-7-Year-Old Finnish Children Speak out

    Science.gov (United States)

    Kyronlampi-Kylmanen, Taina; Maatta, Kaarina

    2012-01-01

    A day-care centre is a place where a child spends most of his/her week nowadays. A day-care centre as an institution of early childhood education has often been studied from the early childhood educators' point of view or within a wider societal context. The children's voices have not been heard much. The purpose of this article is to describe, on…

  11. Department of Defense Human Factors Engineering Technical Advisory Group Minutes of the Meeting, (15th), Held at San Diego, California, on 5-7 November 1985

    Science.gov (United States)

    1985-11-01

    Anthropometry of US Military Personnel 30 Jun 81 Human Factors Engineering Design for Army Materiel 28 Jun 85 HE Guidelines for Mgt Info Sys I SAE...tor_and system effectiveness. Paper presented at NATd~De" fence "Research Group Panel Vl£l~Uorkshop, Shrivenhara, England. Geer, C.W...DUE OT«E [ SPE CIFICATION CHECKS jwj] ANTHROPOMETRY ENVIRONMENTAL EVALUATIONS FACILITY, WORKSTATION EVAl DISPIAYTASK ANALYSIS ERROR RATE

  12. Carbon and nitrogen speciation in nitrogen-rich C-O-H-N fluids at 5.5-7.8 GPa

    Science.gov (United States)

    Sokol, Alexander G.; Palyanov, Yury N.; Tomilenko, Anatoly A.; Bul'bak, Taras A.; Palyanova, Galina A.

    2017-02-01

    Carbon and nitrogen speciation has been studied in high-pressure experiments in the C-O-H-N and C-O-H-N-Fe3C systems at 5.5 to 7.8 GPa and 1100 to 1500 °C using a split-sphere multi-anvil apparatus. Oxygen fugacity in the samples was either buffered by the Mo-MoO2 (MMO) and Fe-FeO (IW) equilibria using a double-capsule technique or left unbuffered. fO2 varied from 2 log units below to +4 log units above the iron-wüstite oxygen buffer (IW) depending on water contents in the charges and buffering. Ultra-reduced fluids contained NH3 as the dominant species, but its concentration was slightly lower, while CH4 was higher at higher temperatures. As oxygen fugacity and temperature increased to fO2 0.7 log units above IW and T ≥ 1400 °C, N2 became the predominant nitrogen species; the dominance among carbon species changed from CH4 and C2-C5 alkanes to oxygenated hydrocarbons and higher alkanes. It has been found out for the first time that the N2-rich fluid lacks methane at fO2 4 log units above IW but may bear a few percent of C2H6, C3H8, and C15-C18 alkanes and within one percent of alcohols, aldehydes, ketones, carboxylic acids, and furans. Thus, the NH3 enrichment of fluids and the nitrogen storage capacity of silicates at depths ∼200 km are expected to be the greatest in cold (1100-1200 °C) and reduced continental lithospheric mantle. In a hotter lithosphere of ∼1400 °C, the concentrations of NH3 and N2 in fluids are similar, and the nitrogen storage capacity of silicates should be relatively low. The stability of some higher alkanes and oxygenated hydrocarbons in nitrogen-rich fluids near the enstatite-magnesite-olivine-diamond/graphite (EMOG/D) equilibrium suggest that these carbon species, together with N2, can survive at the redox barrier, where silicate or silicate-carbonate melts capture them and entrain to shallow mantle.

  13. Synthesis and Crystal Structure of 2-Benzylsulfnyl-3-cyano-5,7-dimethyl-pyrazolo[1,5-a]pyrimidine

    Institute of Scientific and Technical Information of China (English)

    任雪玲; 吴超; 高颖; 邹小毛; 杨华铮

    2004-01-01

    The title compound, C16H14N4S, has been synthesized by the reaction of pentane-2,4-dione with 5-amino-3-benzylthio-4-cyano-l-H-pyrazole in ethanol, and its crystal structure was determined by X-ray diffraction method. The crystal is of monoclinic, space group P21/n with a=8.699(3), b=23.139(9), c=7.536(3) A, β= 92.400(8)°, V= 1515.5(10) A3, Z=4,Mr=294037, Dc= 1.290 g/cm3, λ=0.71073 A,μ(MoKo)=0.212 mm-1 and F(000)=616. The structure was refined to R=0.0533 and wR=0.1141 for 2672 unique reflections with Rint= 0.06.distance of 3.875 A and the angle of 164.8°.

  14. People maintain their sun exposure behaviour in a 5-7-year follow-up study using personal electronic UVR dosimeters

    DEFF Research Database (Denmark)

    Thieden, Elisabeth; Heydenreich, Jakob; Philipsen, Peter A

    2013-01-01

    The main purpose of this study was to investigate whether people change their sun behaviour over a period of 7 years. Thus 32 volunteers, who had all participated in earlier sun exposure studies in 1999-2001, were enrolled in a follow-up study in 2006. They were selected to represent a previous low......, medium and high UVR exposure. They participated for mean 121 days (range 65-157 days) wearing a personal, electronic wrist-borne UVR dosimeter and completed sun exposure diaries. No statistically significant differences were seen from year to year in the estimated annual UVR dose, mean UVR dose per day...... they received a mean for the previous participation years (1999-2001) of 236 SED (median 153 SED, range 24-980 SED). The estimated annual UVR dose for each of the previous sun years and the estimated annual dose for 2006 correlated significantly (R(2) = 0.51; p...

  15. Occupational exposure of healthcare and research staff to static magnetic stray fields from 1.5-7 Tesla MRI scanners is associated with reporting of transient symptoms.

    NARCIS (Netherlands)

    Schaap, Kristel; Christopher-de Vries, Yvette; Mason, Catherine K; de Vocht, Frank; Portengen, Lützen; Kromhout, Hans

    2014-01-01

    OBJECTIVES: Limited data is available about incidence of acute transient symptoms associated with occupational exposure to static magnetic stray fields from MRI scanners. We aimed to assess the incidence of these symptoms among healthcare and research staff working with MRI scanners, and their assoc

  16. 5,7-dihydroxy-2-(3-hydroxy-4, 5-dimethoxy-phenyl-chromen-4-one-a flavone from Bruguiera gymnorrhiza displaying anti-inflammatory properties

    Directory of Open Access Journals (Sweden)

    Rajib Barik

    2016-01-01

    Conclusions: The isolated methoxy-flavone may play a predominant role in the anti-inflammatory properties displayed by BRG leaves. Such activity may involve multiple mechanisms, namely (a modulation of oxidative stress (b inhibition of arachidonic acid metabolism and (c downregulation of pro-inflammatory cytokines probably through NF-κB inhibition.

  17. Control inhibitorio en niños de 5-7 años con TDAH de la ciudad de Manizales

    OpenAIRE

    Revelo de la Cruz, Eliana Verónica; Gómez García, María Eugenia; Cifuentes, Vilma Varela; Zuluaga, Juan Bernardo

    2015-01-01

    Tesis (Maestria en Desarrollo Infantil). Universidad de Manizales. Facultad de Ciencias Sociales y Humanas, 2015 El presente estudio está basado en la investigación cuantitativa, plantea un diseño descriptivo-comparativo de corte transversal. El objetivo, fue analizar el desempeño del control inhibitorio en un grupo de 52 sujetos, niños y niñas, 26 de estos con Trastorno por déficit de atención e hiperactividad (TDAH) de tipo combinado, inatento e hiperactivo/impulsivo y 26 controles...

  18. Proceedings of the Meeting of the Coastal Engineering Research Board (53rd) Held in Fort Lauderdale/Dania, Florida on 5-7 June 1990

    Science.gov (United States)

    1991-08-01

    Lillycrop. CEWES-CD-SE Mr. Kenneth R. Akers. CESAD-EN lAJ James N. Marino , CEWES-CV Dr. Albert G. Holler, Jr., CESAD-EN-IIH Mr. William H. McAnally, CEWES...34 Truilt. Coastal Planiriiig aInd Cor >oration. Coral lai’Ies. Florida Engineering. Sarasota. Florida Dr. S. Ji nathan Siah, Greenhorne and Dr. Elliot F...with subsequent Federal reimbursement. Local preconstruction planning is underway for 8.4 miles of shoreline in Palm Beach County as follows: the Coral

  19. European Symposium on X-Ray Topography and High Resolution Diffraction (2nd) Held in Berlin, Germany on 5-7 September 1994. Programme and Abstracts

    Science.gov (United States)

    1994-09-07

    N L Andrew Philips Research Laboratories, Cross-Oak Lane, Redhill, RH! 5HA, U.K. A Saced6n, E Calleja Dept. Ingenieria Electr6nica, E. T. S. I. T.. U...Matematica e Fisica - 62032 CAMERINO (Italy) * I lnst. Cryst. Russian Acad. of Science, MOSCOW (Rlussia) Si/Ge superlattices (SL) have recently

  20. Nanotechnology-Enabled Sensing: Report of the National Nanotechnology Initiative Workshop, Held in Arlington, Virginia on May 5-7, 2009

    Science.gov (United States)

    2009-05-01

    to detect ozone in water and air, and hotplate transducer arrays coated with nanostructured tin oxide that are used for automotive cabin climate...spectrum and can include mass transit, infrastructure (for example, self- healing materials and stress sensors for bridges or other stressed structures

  1. Dimethyl 2,2′-[(4-oxo-2-phenyl-4H-chromene-5,7-diyldioxy]diacetate: a less densely packed polymorph

    Directory of Open Access Journals (Sweden)

    Nagarajan Sulochana

    2009-02-01

    Full Text Available The title molecule, C21H18O8, crystallizes in two crystal polymorphs, see also Nallasivam, Nethaji, Vembu & Jaswant [Acta Cryst. (2009, E65, o312–o313]. The main difference between the two polymorphs is in the conformation of the oxomethylacetate groups with regard to the almost planar [total puckering amplitude 0.047 (2 Å] chromene ring. In the title compound, the best planes of the oxomethylacetate groups through the non-H atoms are almost perpendicular to the chromene ring [making dihedral angles of 89.61 (6 and 80.59 (5°], while in the second polymorph the molecules are close to planar. Both crystal structures are stabilized by C—H...O.

  2. Installation Restoration Program (IRP) for IRP Sites Numbers 4, 5, 7 and 14. 152 Tactical Reconnaissance Group, Nevada Air National Guard, Reno Tahoe International Airport, Reno, Nevada

    Science.gov (United States)

    1996-01-01

    daily temperature change is 35°F with a maximum daily temperature change of 43.51F occurring in July and August (ASG, 1909). National Oceanic and...MONITORING WELL LOCATION It - ’[ GROUND WATER FLOW DIRECTION II GCROUND WATER EXCEEDING REGULATORY 0 15 3D LIMITS FOR BENZENE EEm ORIGINAL IPIP SITE AREA OF

  3. A parallelization scheme to simulate reactive transport in the subsurface environment with OGS#IPhreeqc 5.5.7-3.1.2

    Science.gov (United States)

    He, W.; Beyer, C.; Fleckenstein, J. H.; Jang, E.; Kolditz, O.; Naumov, D.; Kalbacher, T.

    2015-10-01

    The open-source scientific software packages OpenGeoSys and IPhreeqc have been coupled to set up and simulate thermo-hydro-mechanical-chemical coupled processes with simultaneous consideration of aqueous geochemical reactions faster and easier on high-performance computers. In combination with the elaborated and extendable chemical database of IPhreeqc, it will be possible to set up a wide range of multiphysics problems with numerous chemical reactions that are known to influence water quality in porous and fractured media. A flexible parallelization scheme using MPI (Message Passing Interface) grouping techniques has been implemented, which allows an optimized allocation of computer resources for the node-wise calculation of chemical reactions on the one hand and the underlying processes such as for groundwater flow or solute transport on the other. This technical paper presents the implementation, verification, and parallelization scheme of the coupling interface, and discusses its performance and precision.

  4. Precision Measurement of Neutron Spin Asymmetry A1n at Large x{sub bj} Using CEBAF at 5.7 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Xiaochao Zheng

    2002-09-01

    This dissertation will first give an introduction to the theories and formalism of polarized deep inelastic scattering and a review of the theories of A1n. Next the experiment E99-117 at JLab Hall A will be described, followed by the data analysis. The data presented greatly improve the current world fit of neutron polarized structure functions and provide valuable insight in the understanding of the neutron spin structure.

  5. Issues in Early Childhood Education: Curriculum, Teacher Education, & Dissemination of Information. Proceedings of the Lilian Katz Symposium (Champaign, IL, November 5-7, 2000).

    Science.gov (United States)

    Rothenberg, Dianne, Ed.

    This proceedings compiles papers presented at a symposium convened to honor the contributions that Professor Lilian Katz has made to the field of Early Childhood Education. The introduction to the proceedings provides a brief biography of Dr. Katz, an overview of her contributions in the areas of curriculum, teacher education, and information…

  6. Intracavity optical parametric oscillator at 1.5-7-μm wavelength pumped by passive Q-switched Nd:GdVO4 laser

    Institute of Scientific and Technical Information of China (English)

    Mingwei Gao; Chunqing Gao; Kun Tang; Zhifeng Lin; Xiuyong Zhang

    2008-01-01

    A high-repetition-rate eye-safe optical parametric oscillator(OPO),using a non-critically phase-matched KTP crystal intracavity pumped by a passively Q-switched Nd:GdVO4/Cr4+:YAG laser,is experimentally demonstrated.The conversion efficiency for the average power is 7% from pump diode input to OPO signal output and the slope efficiency is up to 10.3%.With an incident pump power of 7.3 W.the compact intracavity OPO(IOPO)cavity,operating at 15 kHz,produces an average power of 0.57 W at 1570 nm with a pulse width as short as 6 ns.The peak power at 1570 nm is higher than 6.3 kW.

  7. Interagency Symposium on University Research in Transportation Noise (2nd) Held at North Carolina State Univ., Raleigh on June 5-7, 1974. Book of Proceedings, Volume I

    Science.gov (United States)

    1974-06-01

    DIRECTIONAL PATTERN OF BLONN FLAP NOISE AT lf/D-3.75. x/o-5.75, Y/D-2.0 DIFFERENT FLAP LENGTH. H-.W, X/D-5.75, Y/D-2.0. »•• 0 dB FIB . 5A OVERALL...Coward, U.E., Hoshheiser, R.M., Kazin, S.B. and Knott , P.R., "Fan/Compressor Noise Research," Rept« No. FAA-RD-71-85. Vole. I,Il,III,Ma7

  8. Biennial Guidance Test Symposium (16th) Held in Holloman Air Force Base, New Mexico on October 5-7, 1993. Volume 1

    Science.gov (United States)

    1993-10-01

    be raised directly retroreflectors that permit the knowledge of alti- into the ordnance bay. A subsequent review of tude to 6 inches (-0.05 micro-g...Inhouse Centrifuge (29 Inch Radius, 600 Tooth Wheel, Ac1b hn=2 Random Sequence, Load Resistor Doubled to 1 K) SF - 0.244380 Dams = 1.012293 Raw...a finite data set, an approximation to the power spectral density is: S= ( -{XT (o)I (14) For discrete dam , the Fast Fourier Transform (FT) can be

  9. Ecohydrology from Concepts to On-ground Actions: Report of Special Side Event on Ecohydrology-An Interdisciplinary Challenge, January 5-7, 2009 in Bangkok, Thailand

    Institute of Scientific and Technical Information of China (English)

    ZHOU Demin; Shahbaz KHAN

    2009-01-01

    International Hydrological Programme Ⅶ (IHP-Ⅶ) directs the research objectives of hydrologists all over the world from 2008 to 2013. As a key programme contributed to the IHP Ⅶ, UNESCO's Ecohydrology Programme (EHP) has evolved into a trans-disciplinary scientific programme to analyze dynamic relationships between hydrological, social and ecological systems. Twenty international experts from 12 countries were invited by UNESCO to attend the side event on "Ecohydrology--An Interdisciplinary Challenge" in Bangkok, Thailand. It aimed to synthesize knowledge gaps for addressing issues related to critical water systems. This event focused on how better knowledge of the interrelationships between the hydrological cycle, livelihoods and ecosystems could be contributed to more cost-effective and environmental-friendly management. The five themes of the event with 20 keynote lectures were given as fellows.

  10. Trimethylsulfonium 1-amino-6-fluoro-2,3,4,5,7,8,9,10,11,12-decaiodo-1-carba-closo-dodecaborate

    Directory of Open Access Journals (Sweden)

    Guido J. Reiss

    2012-03-01

    Full Text Available In the asymmetric unit of the title salt, C3H9S+·CH2B11FI10N− or (CH33S[1-H2N-6-F-closo-1-CB11I10], both ions lie in general positions. The anion is perfectly ordered and so the positions of the C—NH2 vertex and the fluorine substituent are clearly assigned. The relatively short C—N bond length may be interpreted in terms of a very electron deficient {closo-1-CB11} cluster.

  11. (1E,3E,5E,7E-4,4′-(Octa-1,3,5,7-tetraene-1,8-diyldipyridine

    Directory of Open Access Journals (Sweden)

    K. Travis Holman

    2010-03-01

    Full Text Available The title compound, C18H16N2, crystallizes with one and a half independent molecules in the asymmetric unit, with the half-molecule being completed by crystallographic inversion symmetry. Both independent molecules are almost planar, with the non-H atoms exhibiting r.m.s. deviations from the least-squares molecular plane of 0.175 and 0.118 Å, respectively.

  12. Uniaxial pressure dependence of Tc of untwinned YBa[sub 2]Cu[sub 3]O[sub x] single crystals for x=6. 5-7

    Energy Technology Data Exchange (ETDEWEB)

    Kraut, O.; Meingast, C.; Claus, H. (Kernforschungszentrum Karlsruhe, ITP and INFP (Germany)); Braeuchle, G.; Erb, A.; Mueller-Vogt, G. (Univ. Karlsruhe, Fakultaet fuer Physik (Germany)); Wuehl, H. (Kernforschungszentrum Karlsruhe, ITP and INFP (Germany) Univ. Karlsruhe, Fakultaet fuer Physik (Germany))

    1993-01-15

    The dependence of Tc on uniaxial pressure dTc/dp[sub i] (i=a, b, c) is determined for untwinned YBa[sub 2]Cu[sub 3]O[sub x] single crystals as a function of O-content using ultrahigh-resolution thermal-expansion data and the Ehrenfest relationship. The dTc/dp[sub i] values are found to be highly anisotropic and are likely due to several different effects. For uniaxial-pressure applied parallel to the c-axis, we find a strong O-content (or carrier density) dependence of the dTc/dp[sub c] values, consistent with a simple pressure induced charge transfer model. This model does not, however, explain the large dTc/dp[sub a] and dTc/dp[sub b] values, which have opposite signs and do not show a strong O-content dependence except at x=6.7, where both dTc/dp[sub a] and dTc/dp[sub b] values increase sharply. The a, b effects are discussed in terms of the orthorhombic distortion. (orig.).

  13. Proceedings of the Annual Mechanics of Composites Review (8th) Held at Wright-Patterson AFB, Ohio on 5-7 October 1982.

    Science.gov (United States)

    1983-04-01

    and I. Sheinman , Georgia Institute of Technology 0910-0950 RESEARCH INTO THE DESIGN TECHNOLOGY OF ADVANCED COMPOSITES: 292 P. Lagace and J. Dugundji...IMPERFECTION SENSITIVITY OF FIBER-REINFORCED, COMPOSITE, THIN CYLINDERS G. Simitses, D. Shaw and I. Sheinman , Georgia Institute of Technology The

  14. Validity and use of the UV index: report from the UVI working group, Schloss Hohenkammer, Germany, 5-7 December 2011.

    Science.gov (United States)

    Allinson, Sarah; Asmuss, Monika; Baldermann, Cornelia; Bentzen, Joan; Buller, David; Gerber, Nathalie; Green, Adele C; Greinert, Ruediger; Kimlin, Michael; Kunrath, Julie; Matthes, Ruediger; Pölzl-Viol, Christiane; Rehfuess, Eva; Rossmann, Constanze; Schüz, Natalie; Sinclair, Craig; Deventer, Emilie van; Webb, Ann; Weiss, Wolfgang; Ziegelberger, Gunde

    2012-09-01

    The adequacy of the UV Index (UVI), a simple measure of ambient solar ultraviolet (UV) radiation, has been questioned on the basis of recent scientific data on the importance of vitamin D for human health, the mutagenic capacity of radiation in the UVA wavelength, and limitations in the behavioral impact of the UVI as a public awareness tool. A working group convened by ICNIRP and WHO met to assess whether modifications of the UVI were warranted and to discuss ways of improving its effectiveness as a guide to healthy sun-protective behavior. A UV Index greater than 3 was confirmed as indicating ambient UV levels at which harmful sun exposure and sunburns could occur and hence as the threshold for promoting preventive messages. There is currently insufficient evidence about the quantitative relationship of sun exposure, vitamin D, and human health to include vitamin D considerations in sun protection recommendations. The role of UVA in sunlight-induced dermal immunosuppression and DNA damage was acknowledged, but the contribution of UVA to skin carcinogenesis could not be quantified precisely. As ambient UVA and UVB levels mostly vary in parallel in real life situations, any minor modification of the UVI weighting function with respect to UVA-induced skin cancer would not be expected to have a significant impact on the UV Index. Though it has been shown that the UV Index can raise awareness of the risk of UV radiation to some extent, the UVI does not appear to change attitudes to sun protection or behavior in the way it is presently used. Changes in the UVI itself were not warranted based on these findings, but rather research testing health behavior models, including the roles of self-efficacy and self-affirmation in relation to intention to use sun protection among different susceptible groups, should be carried out to develop more successful strategies toward improving sun protection behavior.

  15. Simultaneous transmission of 256-QAM WIMAX at 5.7GHz and optically generated impulse radio UWB over fiber for indoor wireless multi-services

    DEFF Research Database (Denmark)

    Yu, Xianbin; Yin, Xiaoli; Gibbon, Timothy Braidwood;

    2010-01-01

    Fiber transmission of simultaneous optically generated FCC compliant 625Mbps impulse radio UWB and 80Mbps 256-QAM IEEE 802.16 WIMAX signals is experimentally demonstrated by using a single directly modulated light source.......Fiber transmission of simultaneous optically generated FCC compliant 625Mbps impulse radio UWB and 80Mbps 256-QAM IEEE 802.16 WIMAX signals is experimentally demonstrated by using a single directly modulated light source....

  16. Proceedings of the Biennial EO/EEO Research Symposium (4th) Held in Cocoa Beach, Florida on December 5-7, 2001

    Science.gov (United States)

    2003-01-01

    Schizophrenia and Affective Disorders Among Blacks, 37 Hospital and Community Psychiatry 61, 65 (1986); S. I. Abramowitz & Joan Murray Race Effects...sense of empowerment . Yet, others describe a “shield” they must put on in order to protect themselves in White society. Many discuss social networks...is better than self-derogation as a response to racial oppression.ඍ One female professional links this sense of empowerment to position and

  17. Precision Measurement of Neutron Spin Asymmetry A$n\\atop{1}$ at Large xbj Using CEBAF at 5.7 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Xiaochao [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2002-12-01

    This dissertation will first give an introduction to the theories and formalism of polarized deep inelastic scattering and a review of the theories of A$n\\atop{1}$. Next the experiment E99-117 at JLab Hall A will be described, followed by the data analysis. The data presented greatly improve the current world fit of neutron polarized structure functions and provide valuable insight in the understanding of the neutron spin structure.

  18. Proceedings of the 1980 Tri-Service Conference on Corrosion, 5-7 November 1980, US Air Force Academy, Colorado. Volume 1

    Science.gov (United States)

    1980-11-01

    control 51.3 2. lauric acid 62 3. aluminum stearate 35 4. stearic acid 73 5. palmitic acid 72.4 6. vinytriacetooxysilane 64 7. sodium vanadate 32 8...their conference in Washington today. (Slide 51) The most recently established tool which will enable us to obtain greatest benefit from our program...for corrosion control was controlled addition of ferrous ions to the flowing, polluted seawater environment. It was determined that benefit was

  19. Nuclear Science Symposium, 27th, and Symposium on Nuclear Power Systems, 12th, Orlando, Fla., November 5-7, 1980, Proceedings

    Science.gov (United States)

    Martini, M.

    1981-02-01

    Advances in instrumentation for use in nuclear-science studies are described. Consideration is given to medical instrumentation, computerized fluoroscopy, environmental instrumentation, data acquisition techniques, semiconductor detectors, microchannel plates and photomultiplier tubes, reactor instrumentation, neutron detectors and proportional counters, and space instrumentation.

  20. Proceedings of the EMU Conference on Foreign Languages for Business and the Professions (Dearborn, Michigan, April 5-7, 1984). Part III: Taking the Humanities to Business.

    Science.gov (United States)

    Voght, Geoffrey M., Ed.

    Part III of the proceedings contains 12 presentations. They are: "The Role of Business Language in the Traditional Curriculum" (Michel Rocchi); "Foreign Languages for Business and the Professions Belong in the Liberal Arts" (Robert A. Kreiter); "How Much and How Far? Commercial French and the Student, Instructor, Administrator, and the Business…

  1. Proceedings of the Workshop on Future Directions in Computer Architecture and Software, Held in Charleston, South Carolina on 5-7 May 1986,

    Science.gov (United States)

    1986-08-30

    advantage of the muL. t i pFe 1. processing units to allow recovery from hardware fail ure=. Brriefly, the detection of a pr oc es. sor fai lure by...partition muist be reconciled to a common value. Every site keep,~ lo-, or audit trail, and when a database recovers a partitioning, databases in...241 / - ...I~- .’ ~ ~ 10. BJORK, L. A., "Generalized Audit Trail Requirements and Concepts for I)atabase Applications," IB.MI Systems Journal, pp. 229

  2. Proceedings of the Princeton Workshop on New Approaches to Experimental Turbulence Research Held in Princeton, New Jersey on September 5 - 7, 1990

    Science.gov (United States)

    1991-06-24

    for Rept. INN-5). The Japanese call this mode of research " kaizen ’ some economists call it learning-by-doing, but the name is not the important...major edge since the time it first came together in Toyota in the early 1970’s. Why do I digress into manufacturing> Because manufacturing, not science

  3. The Incidence of Attachment Objects and Oral Habits at Bedtime in Two Longitudinal Samples of Children Aged 1.5-7 Years.

    Science.gov (United States)

    Mahalski, Pauline A.

    1983-01-01

    Mothers in one sample were interviewed when children were 1.5, 2, and 2.5 years old, while mothers in the other sample answered questionnaires when their children were 3.5, 5, and 7 years old. Strong emotional attachment to objects and finger-sucking were most prevalent around 2 years of age. (MP)

  4. Orlando Magic: report from the 57th meeting of the American Society of Haematology, 5-7 December 2015, Orlando, USA.

    Science.gov (United States)

    Mazzarella, Luca

    2016-01-01

    The 57th American Society of Haematology (ASH) meeting held in Orlando, FL was certainly the year when myeloma management changed for good, with a plethora of newly Food and Drug Administration (FDA)-approved drugs showing impressive outcome improvements and the introduction of new techniques for disease monitoring. Also, chimeric antigen receptor (CAR) T cells continued their triumphal march, consolidating their success in lymphoma and chronic lymhocytic leukaemia (CLL) and venturing into new fields such as again multiple myeloma. Some experimental drugs showed long-awaited results (midostaurin in FLT3-mutated acute myeloid leukaemia (AML)) and some brand new drugs showed promising results in the clinic after extensive preclinical studies, such as those targeting new epigenetic factors (histone methyltransferases) and apoptosis.

  5. Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas

    Institute of Scientific and Technical Information of China (English)

    Crystal S Seldon; Lauren E Colbert; William A Hall; Sarah B Fisher; David S Yu; Jerome C Landry

    2016-01-01

    Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies.

  6. An Analysis of the Mineral Industries of the Republics of China, the Philippines, and Korea, the Kingdom of Thailand, and New Zealand. Volume II. Chapters 5-7.

    Science.gov (United States)

    1984-12-01

    inhabi- tants. 2 Thailand’s geography is varied, being dominated in the central plain by the Mae Nam Chao Phraya River system. The northeast is a dry...1950’s were a very large hydroelectric power potential of the Chao Phraya .iver and smaller rivers , lignite deposits, and small oil de- posits. After...the Chao Phraya delta, carrying passengers, large quantities of rice, and freight. These waterways are navigable 700 kilometers inland during the wet

  7. Photometry of the Oort Cloud comet C/2009 P1 (Garradd): Pre-perihelion observations at 5.7 and 2.5 AU

    Science.gov (United States)

    Mazzotta Epifani, E.; Snodgrass, C.; Perna, D.; Dall'Ora, M.; Palumbo, P.; Della Corte, V.; Alvarez-Candal, A.; Melita, M.; Rotundi, A.

    2016-11-01

    The aim of this paper is to contribute to the characterization of the general properties of the Long Period Comets (LPCs) family, and in particular to report on the dust environment of comet C/2009 P1 (Garradd). The comet was observed at two epochs pre-perihelion, at ~6 AU and at ~2.5 AU: broad-band images have been used to investigate its coma morphology and properties and to model the dust production rate. Comet C/2009 P1 (Garradd) is one of the most active and "dust producing" LPCs ever observed, even at the large heliocentric distance rh~6 AU. Its coma presents a complex morphology, with subtle structures underlying the classical fan-shaped tail, and, at rh~2.5 AU, also jet-like structures and spiralling outflows. In the reference aperture of radius ρ=5°×104 km, the R-Afρ is 3693±156 cm and 6368±412 cm, in August 2010 (rh~6 AU) and July 2011 (rh~2.5 AU), respectively. The application of a first order photometric model, under realistic assumptions on grain geometric albedo, power-law dust size distribution, phase darkening function and grain dust outflow velocity, yielded a measure of the dust production rate for the two epochs of observation of Qd=7.27×102 kg/s and Qd=1.37×103 kg/s, respectively, for a reference outflow dust velocity of vsmall=25 m/s for small (0.1-10 μm) grains and vlarge=1 m/s for large (10 μm-1 cm) grains. These results suggest that comet Garradd is one of the most active minor bodies observed in recent years, highly contributing to the continuous replenishment of the Interplanetary Dust Complex also in the outer Solar System, and pose important constraints on the mechanism(s) driving the cometary activity at large heliocentric distances.

  8. Proceedings of the Annual Space Surveillance Workshop (12th) Held in Lexington, Massachusetts on 5-7 April 1994. Volume 1

    Science.gov (United States)

    1994-04-07

    Klinkrad , H., ’Space Debris in Elliptical Orbits’, 18th Int. Symposium on Space Technology and Science, Kagoshima, Japan, 19-22 May 1992. 2. Kessler, D...8217History of On-Orbit Satellite Fragmentations’ 18. Gonzales-Laguna, E., and Klinkrad , H. H., ’FOCUS-1 Fast Orbit Computation Utility Software’, MAS WP 305...7, 1993. [2] Sdunnus, H., Klinkrad , H., An introduction to the ESA reference model for space debris and meteor- oids, First European Conference on

  9. A decadal cirrus clouds climatology from ground-based and spaceborne lidars above the south of France (43.9° N–5.7° E

    Directory of Open Access Journals (Sweden)

    C. Hoareau

    2013-07-01

    Full Text Available This study provides an analysis of cirrus cloud properties at midlatitude in the southern part of France from ground-based and spaceborne lidars. A climatology of cirrus cloud properties and their evolution over more than 12 yr is presented and compared to other mid-latitude climatological studies. Cirrus clouds occur ~37% of the total observation time and remain quasi-constant across seasons with a variation within ~5% around the mean occurrence. Similar results are obtained from CALIOP and the ground-based lidar, with a mean difference in occurrence of ~5% between both instruments. From the ground-based lidar data, a slight decrease in occurrence of ~3% per decade is observed but found statistically insignificant. Based on a clustering analysis of cirrus cloud parameters, three distinct classes have been identified and investigations concerning their origin are discussed. Properties of these different classes are analysed, showing that thin cirrus in the upper troposphere represent ~50% of cloud cover detected in summer and fall, decreasing by 15–20% for other seasons.

  10. Proceedings of the 1980 Tri-Service Conference on Corrosion, 5-7 November 1980, US Air Force Academy, Colorado. Volume 2

    Science.gov (United States)

    1980-11-01

    Covered the fasr’or heads -ith Corroc ion Preventive Compound, MIL-C-16173, Crade I. H-3 AIRCRAFT 1;1 I’ll’ NORMA ., ANTD AL[FRNf’TE AtJE’FrTNA The 11...of SO4 NO- RH, and time. Temperature, TSP, and SO appeared prmrl fS 4= 3 2 apae to be insignificant. Because of an observed covariance between S04

  11. Working Group on quality, safety and efficacy of typhoid Vi capsular polysaccharide conjugate, vaccines, Jeju, Republic of Korea, 5-7 September 2012.

    Science.gov (United States)

    Jones, Chris; Lee, Chung Keel; Ahn, Chiyoung; Shin, Jinho; Knezevic, Ivana

    2013-09-23

    Typhoid fever is a gastrointestinal disease transmitted through the ingestion of contaminated water or food. The bacterium, Salmonella enterica subspecies enterica serovar Typhi is an important cause of illness and death in many poor countries where access to safe water and basic sanitation is limited. Humans are the only natural host and reservoir of S. Typhi. Typhoid fever causes around 21 million cases and at least 200,000 deaths per year. Currently, several groups are developing typhoid conjugate vaccines that are expected to be safe and effective in infancy or early childhood. The World Health Organization convened a meeting, in collaboration with the Korea Food and Drug Administration, with experts group in September 2012 to develop guidelines for regulatory evaluation of the quality, safety and efficacy of typhoid conjugate vaccines. This report summarizes collective views on scientific and technical issues that need to be considered in the guidelines.

  12. ECOMIT : 5th international scientific conference on sustainable farming systems : November 5-7, 2008 in Piešt'any, Slovakia

    NARCIS (Netherlands)

    Lehocka, Z.; Klimekova, M.; Sukkel, W.

    2008-01-01

    Ecomit is the name of the conference on sustainable agriculture that has been organized for the 5th time in Slovakia. Ecomit stands for ecological meeting and these motives been the leading motives for the organizers and supporters of Ecomit. The conference was focused on knowledge about sustainable

  13. Seminar on Soviet Military Manpower: A Focus on the Soviet Military District, held at the University of Edinburgh, Edinburgh, Scotland, 5-7 April 1978.

    Science.gov (United States)

    1978-01-01

    such things as human factors engineering, the scientific organization of work, and thorough competence in technical matters, military pedagogy and...important enfo geetering vr man’ s capabilities and for instilling in him a love for his military specialty which is psychologically very important in...war. The ball, therefore, passes to the court of military pedagogy : how to effect the training of the soldier who, it has been admitted, may not have

  14. Environmental Impact Research Program and Defense Natural Resources Program: Section 7.5.7, US Army Corps of Engineers Wildlife Resources Management Manual

    Science.gov (United States)

    1992-02-01

    have some value to beekeepers for honey production. Major uses of autumn olive are described below; wildlife value is discussed under a separate... fermentation and damage from heat. The fruits may be lightly mashed against a 1/8-in. (3.1-mm) hardware cloth screen with a small block of wood covered

  15. Proceedings of the Symposium on Fluid-Solid Surface Intractions (2nd) Held at the Naval Ship Research and Development Center, Bethesda, Maryland, June 5-7, 1974,

    Science.gov (United States)

    1974-11-29

    Berkeley, USA, Report No. AS-68-6, (8) R.A. Millikan ; Physical Review, Vol. 21, No. 3, 217 (March 1923). 57 Atomic Beam Scattering from Clean Crystal...diam.) into the scattering chamber. The latter is pumped, by a titanium sublimation pump in parallel with a turbomolecular pump backed by a small oil ...the Hagen-Poiseuille solution. If pl-P2 denotes the pressure drop along the pipe length z 1 = L, the mean velocity v = I fd/2 v 2wrdr is id 0 Z - Pl-P2

  16. Proceedings of the Tri-Service Conference on Corrosion (1987) Held at the Air Force Academy, Colorado on 5-7 May 1987.

    Science.gov (United States)

    1987-05-01

    n F - .4 L* 4 PROTECTIVE SCHEMES FOR MAGNESIUM ALLOY ZE4 IA- T5 _ _ _ _ _ _ I _ _ _ _ _ _ CON,ERSION UoRTIN CONJERSION COATING: HOE 4NODIZE 3 CI[110H...Composites in DS2 DS2 Al 6061 Al 6063 Al 6061/SiC Volume % (mpy) (mpy) (mpy) 100 0.23 0.12 0.22 50 445 421 69 30 >1000 766 444 "e 20 >1000 717 888 0...34 -’ , .,A * % % A . . . A . % ~ * % V %A % %A % % % %% - 4 • ’-- . - Table 9. Corrosion Rates of Alumirum 6063 -T6 in DS2 Diluted with Distilled Water

  17. Education for Rural Development in Asia: Experiences and Policy Lessons. FAO/UNESCO Seminar (Bangkok, Thailand, November 5-7, 2002).

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). International Inst. for Educational Planning.

    More than half of the world's population, and more than 70 percent of the world's poor live in rural areas where hunger, illiteracy, and low school achievement are common. Education in rural areas is crucial for achieving sustainable development. The Food and Agriculture Organization (FAO) of the United Nations and UNESCO's International Institute…

  18. Di-μ-chlorido-bis({4-[bis(trimethylsilylamino]-6-chloro-2,2,8,8-tetramethyl-5,7-bis(trimethylsilyl-3,5,7-triaza-4,6-diphospha-2,8-disilanon-3-en-4-ido-κ2P,P′}palladium(II diethyl ether disolvate

    Directory of Open Access Journals (Sweden)

    Martha Höhne

    2016-06-01

    Full Text Available The title compound, [Pd2(C18H54Cl2N4P2Si62Cl2]·2C4H10O, features a dinuclear chloride-bridged palladium complex bearing two equivalents of the novel monoanionic mixed valent (λ3-P—N—(λ5-P ligand. A metal catalyzed coupling of two aminoiminophosphines and a shift of one chlorine from the metal to the phosphorus results in the (λ3-P—N—(λ5-P ligand. The molecule contains a planar bimetallic Pd2Cl2 core with a crystallographic centre of inversion at the mid-point of the Pd...Pd line. The Pd atoms are in a distorted square-planar arrangement, where the P/Pd/P and Cl/Pd/Cl planes are twisted with respect to each other by a dihedral angle of 7.57 (4°. The P—Pd—P bite angle is 71.380 (18°. Intramolecular C—H...Cl interactions are observed. In the crystal, the diethyl ether solvent molecule is disordered over two sites, with an occupancy ratio of 0.788 (5:0.212 (5.

  19. Problem Definition Study on TAX (1-acetylhexahydro-3,5-dinitro-1,3,5- triazine), SEX (1-acetyloctahydro-3,5,7-trinitro-1,3,5,7-tetrazocine), Lead Salicylate and Lead Beta-Resorcylate 2-Nitrodiphenylamine and Ethyl Centralite

    Science.gov (United States)

    1979-07-01

    11-12 11-2. Analysis of Waste Streams for RDX, HHX, TAX and SEX . . . TI-19 11-3. Percutaneous Administracion of HMX in Various...detailed search of the literature and numerous personal contacts. During the literature search, the following sources were reviewed for pertinent...revealed very little information on TAX. Personal contacts were made with Army Ammunition Plant personnel and Army and civilian researchers. The

  20. Ukiyo-e Adamson-Ericus

    Index Scriptorium Estoniae

    2003-01-01

    Näitus "300 aastat jaapani puulõike traditsiooni. Ukiyo-e puulõiked meister Keizo Sato töökojast". Esitletakse faksiimiletõmmiseid Hokusai, Hiroshige, Utamaru, Sharaku jt. kunstnike töödest. Näituse koostasid Keizo Sato (sünd. 1940) ja Tuula Moilanen. 14.-16. VII Jaapani-teemaline kunstilaager 8-12aastastele lastele

  1. Põdrad tõid Merily Salurale Soome fotovõistlusel tunnustuse / Ulvar Käärt

    Index Scriptorium Estoniae

    Käärt, Ulvar, 1982-

    2010-01-01

    Fotovõistlusel "Baltic Sea - Young Wildlife Photographer 2010" pälvisid tunnustuse kolm eesti noort looduspiltnikku. Üheksa Läänemere-äärse riigi 15- kuni 18-aastastele fotohuvilistele korraldatud võistlusel valiti riigiti parimaid ülesvõtteid kolmes kategoorias. Üldvõitja - sakslane Hermann Hirsch. Eesti parim alagrupis "Läänemeri ja inimene" Johanna Maria Paulson, alagrupis "Looduses mobiiltelefoniga" Marilis Jõgi, alagrupis "Kodumaa loodus" Merily Salura

  2. Ukiyo-e Adamson-Ericus

    Index Scriptorium Estoniae

    2003-01-01

    Näitus "300 aastat jaapani puulõike traditsiooni. Ukiyo-e puulõiked meister Keizo Sato töökojast". Esitletakse faksiimiletõmmiseid Hokusai, Hiroshige, Utamaru, Sharaku jt. kunstnike töödest. Näituse koostasid Keizo Sato (sünd. 1940) ja Tuula Moilanen. 14.-16. VII Jaapani-teemaline kunstilaager 8-12aastastele lastele

  3. Põdrad tõid Merily Salurale Soome fotovõistlusel tunnustuse / Ulvar Käärt

    Index Scriptorium Estoniae

    Käärt, Ulvar, 1982-

    2010-01-01

    Fotovõistlusel "Baltic Sea - Young Wildlife Photographer 2010" pälvisid tunnustuse kolm eesti noort looduspiltnikku. Üheksa Läänemere-äärse riigi 15- kuni 18-aastastele fotohuvilistele korraldatud võistlusel valiti riigiti parimaid ülesvõtteid kolmes kategoorias. Üldvõitja - sakslane Hermann Hirsch. Eesti parim alagrupis "Läänemeri ja inimene" Johanna Maria Paulson, alagrupis "Looduses mobiiltelefoniga" Marilis Jõgi, alagrupis "Kodumaa loodus" Merily Salura

  4. 5-7 Year Old Children's Conceptions of Behaving Artifacts and the Influence of Constructing Their Behavior on the Development of Theory of Mind (ToM) and Theory of Artificial Mind (ToAM)

    Science.gov (United States)

    Spektor-Precel, Karen; Mioduser, David

    2015-01-01

    Nowadays, we are surrounded by artifacts that are capable of adaptive behavior, such as electric pots, boiler timers, automatic doors, and robots. The literature concerning human beings' conceptions of "traditional" artifacts is vast, however, little is known about our conceptions of behaving artifacts, nor of the influence of the…

  5. Evaluation of Effects of Quercetin (3, 3’, 4’, 5, 7-pentohidroxyflavon on Apoptosis and Telomerase Enzyme Activity in MCF-7 and NIH-3T3 Cell Lines Compared with Tamoxifen

    Directory of Open Access Journals (Sweden)

    Ayşe Ak

    2011-09-01

    Full Text Available Objective: Quercetin has been shown to inhibit the proliferation of cancer cells. Tamoxifen is used for breast cancer. In this study, we have aimed to investigate the effects of quercetin and tamoxifen on telomerase enzyme activity and apoptosis in two cell lines.Methods: In this study, 10, 50 and 100 µM of quercetin and tamoxifen were used to treat MCF-7 and NIH-3T3. Apoptosis was determined by the TUNEL method (Terminal Deoxynucleotide Transferase dUTP Nick End Label and telomerase enzyme activity was determined by ELISA (Enzyme-Linked Immunosorbent Assay. Results: In the NIH3T3 cell line, only 100 µM quercetin and tamoxifen induced significant apoptosis. In the MCF-7 cell line 10 µM and 100 µM quercetin in the 24th hour and 100 µM quercetin in the 72nd hour induce apoptosis. In 24th and 48th hours, 50 µM tamoxifen and 100 µM tamoxifen in the 24th and 48th hours induce apoptosis in the MCF-7 cell line. In MCF-7 and NIH-3T3 cell lines, all doses of quercetin and tamoxifen reduced telomerase enzyme activity compared to the control group. Conclusion: In this study, it was shown that quercetin has similar effects to tamoxifen. However quercetin induces apoptosis more than decreasing telomerase enzyme activities, being different from tamoxifen. We hope that the findings will assist in developing new therapeutic pathways for preventing breast cancer. However, there should be many more studies in order to discover quercetin and other potential drugs.

  6. A Potent Inhibitor of Phosphoinositide 3-Kinase (PI3K) and Mitogen Activated Protein (MAP) Kinase Signalling, Quercetin (3, 3', 4', 5, 7-Pentahydroxyflavone) Promotes Cell Death in Ultraviolet (UV)-B-Irradiated B16F10 Melanoma Cells

    Science.gov (United States)

    Rafiq, Rather A.; Quadri, Afnan; Nazir, Lone A.; Peerzada, Kaiser; Ganai, Bashir A.; Tasduq, Sheikh A.

    2015-01-01

    Ultraviolet (UV) radiation–induced skin damage contributes strongly to the formation of melanoma, a highly lethal form of skin cancer. Quercetin (Qu), the most widely consumed dietary bioflavonoid and well known inhibitor of phosphoinositide 3-kinase (PI3K) and mitogen activated protein (MAP) kinase signalling, has been reported to be chemopreventive in several forms of non-melanoma skin cancers. Here, we report that the treatment of ultraviolet (UV)-B-irradiated B16F10 melanoma cells with quercetin resulted in a dose dependent reduction in cell viability and increased apoptosis. The present study has brought out that the pro-apoptotic effects of quercetin in UVB-irradiated B16F10 cells are mediated through the elevation of intracellular reactive oxygen species (ROS) formation, calcium homeostasis imbalance, modulation of anti-oxidant defence response and depolarization of mitochondrial membrane potential (ΔΨM). Promotion of UVB-induced cell death by quercetin was further revealed by cleavage of chromosomal DNA, caspase activation, poly (ADP) ribose polymerase (PARP) cleavage, and an increase in sub-G1 cells. Quercetin markedly attenuated MEK-ERK signalling, influenced PI3K/Akt pathway, and potentially enhanced the UVB-induced NF-κB nuclear translocation. Furthermore, combined UVB and quercetin treatment decreased the ratio of Bcl-2 to that of Bax, and upregulated the expression of Bim and apoptosis inducing factor (AIF). Overall, these results suggest the possibility of using quercetin in combination with UVB as a possible treatment option for melanoma in future. PMID:26148186

  7. CCDC 1009378: Experimental Crystal Structure Determination : 2,4,8,10-tetra-t-butyl-6-(4-t-butylphenyl)-5,7-dihydroindolo[2,3-b]carbazole chloroform solvate

    KAUST Repository

    Luo, Ding

    2014-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  8. Observation of narrow (3$\\pi$)$\\pm$ peaks in the $\\delta$ and A$\\_{1}$ regions in $\\overline{p}p$ annihilations at 5.7 GeV/c

    CERN Document Server

    Atherton, Henry W; French, Bernard R; Ghidini, B; Hilpert, H G; Kinson, J B; Mandelli, L; Moebes, J P; Myklebost, K; Nellen, B; Quercigh, Emanuele; Simák, V

    1973-01-01

    In the pi /sup +/ pi /sup -/ pi /sup +or-/ systems of the reactions pp to KKm pi (m=4,5) two narrow peaks are observed at the positions of the delta and A/sub 1/ mesons. The measured masses and widths are: M= (956+or-7)MeV, Gamma =(46+or-22)MeV for the delta and M=(1076+or-5)Me V, Gamma =(36/sup +20//sub -15/)MeV, for the A/sub 1/. Their decay modes and spin-parities are shown to be mainly 3 pi , J/sup P/=0/sup - / and rho pi , J/sup P/=1/sup +/(D-wave) respectively. (8 refs).

  9. Theoretical Study for High-Energy-Density Compounds Derived from Cyclophosphazene. IV. DFT Studies on 1,1-Diamino-3,3,5,5,7,7-hexaazidocyclotetraphosphazene and Its Isomers

    Directory of Open Access Journals (Sweden)

    Man Wu

    2009-08-01

    Full Text Available In the present study, a theoretical study of 1,1-diaminohexaazidocyclo-tetraphophazene (DAHA and its isomers has been performed, using quantum computational density functional theory (B3LYP and B3PW91 methods with 6-31G* and 6-31G** basis sets implemented in Gaussian 03 program suite. Molecular structure and bonding, vibrational frequencies, Milliken population analysis, and natural bond orbit (NBO have been studied. The heats of formation from atomization energies have also been calculated based on the optimized geometry. The obtained heats of formation data are compared with their homologous cyclophosphazene in order to demonstrate the accuracy of the methods, which indicate that the studied compounds might be potentially used as high energetic materials. In addition, the relative stability of five isomers have been deduced based on the total energy and the gap of frontier orbital energies.

  10. [5.-7. augustini 2008 korraldas Eesti Emakeeleõpetajate Selts koostöös Eesti Kirjanike Liidu ja Eesti Keele Kui Teise Keele Õpetajate Liiduga Raplamaal suvekooli "Kirjanduse sisu ja ümbrispaber"

    Index Scriptorium Estoniae

    2008-01-01

    Ettekannetega esinesid Jan Kaus, Sirje Olesk, Harri Jõgisalu, Aidi Vallik, Katrin Reimus, Jaanus Vaiksoo, Jürgen Rooste, Leelo Tungal, Priit Kruus, Mathura, Hando Runnel, Kristiina Ehin, Ly Ehin, Andres Ehin, Krista Kaer, Karl Martin Sinijärv, Doris Kareva, Rein Veidemann, Peeter Helme ja Piibe Leiger

  11. Crystal structure and absolute configuration of (3aS,4S,5R,7aR-2,2,7-trimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxole-4,5-diol

    Directory of Open Access Journals (Sweden)

    Mario A. Macías

    2015-09-01

    Full Text Available The absolute configuration of the title compound, C10H16O4, determined as 3aS,4S,5R,7aR on the basis of the synthetic pathway, was confirmed by X-ray diffraction. The molecule contains a five- and a six-membered ring that adopt twisted and envelope conformations, respectively. The dihedral angle between the mean planes of the rings is 76.80 (11° as a result of their cis-fusion. In the crystal, molecules are linked by two pairs of O—H...O hydrogen bonds, forming chains along [010]. These chains are further connected by weaker C—H...O interactions along [100], creating (001 sheets that interact only by weak van der Waals forces.

  12. Home-School Alliances: Approaches to Increasing Parent Involvement in Children's Learning in Upper Elementary and Junior High Schools (Grades 4-9). Proceedings of the NIE Conference on Home-School Alliances (Washington, DC, October 5-7, 1980).

    Science.gov (United States)

    Safran, Daniel, Ed.

    This report is a transcript of presentations from the 1980 Conference on Home-School Alliances, defined as specific coordination strategies between home and school, and developed to further the social and academic development of children and youths. Following the preface, brief overview of the purpose and nature of the conference, and the…

  13. CCDC 1017115: Experimental Crystal Structure Determination : 6-butyl-4,8-bis(thiophen-2-yl)-5H-[1,2,5]thiadiazolo[3,4-f]isoindole-5,7(6H)-dione

    KAUST Repository

    Nielsen, Christian B.

    2016-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  14. Ethyl (1R*,10S*,12R*,15S*-4-Hydroxy-2-oxo-15- (2-oxo-1-pyrrolidinyl-9-oxatetracyclo[10.2.2.01,10.03,8]hexadeca-3,5,7,13-tetraene-13-carboxylate

    Directory of Open Access Journals (Sweden)

    Jorge Heredia-Moya

    2017-01-01

    Full Text Available N-Vinylpirrolidinone reacts with (E-ethyl 5-hydroxy-3-(4-oxo-4H-chromen-3-yl acrylate (1 through a domino reaction similar to that reported reaction for ethyl vinyl ether. Inverse electron demand Diels–Alder (IEDDA–elimination-IEDDA generates isomeric tetracycles 5 and 6. The assignment of the relative stereochemistry of the products was made by comparing the proton couplings with those obtained by reaction with ethyl vinyl ether.

  15. A Potent Inhibitor of Phosphoinositide 3-Kinase (PI3K and Mitogen Activated Protein (MAP Kinase Signalling, Quercetin (3, 3', 4', 5, 7-Pentahydroxyflavone Promotes Cell Death in Ultraviolet (UV-B-Irradiated B16F10 Melanoma Cells.

    Directory of Open Access Journals (Sweden)

    Rather A Rafiq

    Full Text Available Ultraviolet (UV radiation-induced skin damage contributes strongly to the formation of melanoma, a highly lethal form of skin cancer. Quercetin (Qu, the most widely consumed dietary bioflavonoid and well known inhibitor of phosphoinositide 3-kinase (PI3K and mitogen activated protein (MAP kinase signalling, has been reported to be chemopreventive in several forms of non-melanoma skin cancers. Here, we report that the treatment of ultraviolet (UV-B-irradiated B16F10 melanoma cells with quercetin resulted in a dose dependent reduction in cell viability and increased apoptosis. The present study has brought out that the pro-apoptotic effects of quercetin in UVB-irradiated B16F10 cells are mediated through the elevation of intracellular reactive oxygen species (ROS formation, calcium homeostasis imbalance, modulation of anti-oxidant defence response and depolarization of mitochondrial membrane potential (ΔΨM. Promotion of UVB-induced cell death by quercetin was further revealed by cleavage of chromosomal DNA, caspase activation, poly (ADP ribose polymerase (PARP cleavage, and an increase in sub-G1 cells. Quercetin markedly attenuated MEK-ERK signalling, influenced PI3K/Akt pathway, and potentially enhanced the UVB-induced NF-κB nuclear translocation. Furthermore, combined UVB and quercetin treatment decreased the ratio of Bcl-2 to that of Bax, and upregulated the expression of Bim and apoptosis inducing factor (AIF. Overall, these results suggest the possibility of using quercetin in combination with UVB as a possible treatment option for melanoma in future.

  16. Proceedings of Workshop on Continuing the Revolution in Military Affairs (RMA) (3rd), held on June 5-7, 2001 at The Clubs of Quantico, Quantico Marine Base, Quantico, VA

    Science.gov (United States)

    2001-09-01

    Mexico , and a Ph.D. in Engineering from the University of California, Davis. He is married to Dr. Sydell Gold. The Golds reside in McLean, VA and...the need for the seamless exchange of information ( Hambre - 2000). This resulted in the Department s focus on the need to move toward an Enterprise...Explaining the Rising Cost of Aviation Depot Level Repairables (AVDLR) Hambre , J.J. (1999): Department of Defense Reform Initiative Directive (DRID

  17. 2,2′-(1,3,5,7-Tetraoxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]isoindole-2,6-diyldiacetic acid N,N-dimethylformamide disolvate

    Directory of Open Access Journals (Sweden)

    Chunhua Ge

    2009-10-01

    Full Text Available The asymmetric unit of the title compound, C14H8N2O8·2C3H7NO or L·2DMF (DMF = N,N-dimethylformamide, contains one half of the centrosymmetric molecule L and one solvent molecule, which is disordered between two orientations in a 0.555 (4:0.445 (4 ratio. Intermolecular O—H...O hydrogen bonds link one L and two DMF molecules into a centrosymmetric hydrogen-bonded cluster. The crystal packing is further stabilized by weak intermolecular C—H...O hydrogen bonds.

  18. 3,10,14,21-Tetrakis(4-methoxyphenylpentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21,2,4(9,5,7,10,13,15(20,16,18-decaen-12-one chloroform monosolvate

    Directory of Open Access Journals (Sweden)

    S. Gopinath

    2014-08-01

    Full Text Available The asymmetric unit of the title compound, C49H36O6·CHCl3, contains half an organic molecule, the complete molecule being generated by the operation of a crystallographic twofold rotation axis, and half a highly disordered chloroform molecule. The contribution to the diffraction pattern of the latter was removed using the program SQUEEZE in PLATON [Spek (2009. Acta Cryst. D65, 148–155]; the unit-cell characteristics take into account the presence of CHCl3. The dihedral angles between the planes of the naphthalene ring system and the methoxybenzene rings are 71.05 (7 (syn to the central C=O group and 57.27 (6° (anti to the central C=O group. In the crystal, molecules are linked by C—H...O interactions, generating C(12 chains running parallel to the b axis.

  19. 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin): X-ray diffraction structures of the naringenin enantiomers and DFT evaluation of the preferred ground-state structures and thermodynamics for racemization

    Science.gov (United States)

    Nesterov, Volodymyr V.; Zakharov, Lev N.; Nesterov, Vladimir N.; Calderon, Jose G.; Longo, Antonella; Zaman, Khadiza; Choudhury, Feroza Kaneez; Farrell, William; Shulaev, Vladimir; Richmond, Michael G.

    2017-02-01

    The R- and S-enantiomers of naringenin were separated by chiral supercritical fluid (SCF) and the absolute configuration of each enantiomer was established by X-ray crystallography. The solid-state data is in agreement with the reported circular dichroism spectra. Both enantiomers crystallize in the monoclinic crystal system in the space group P21 with two independent molecules in the asymmetric unit. In all molecules, the pyrone ring adopts a flattened chair-like conformation in which the C1 atom deviates from the plane drawn through the remaining five atoms of this heterocycle. The 4-hydroxyphenyl substituent located at C1 of the pyrone ring occupies an equatorial position and lies in a plane that is almost perpendicular to the aromatic platform associated with the heterocyclic portion of the molecule. Strong intramolecular O-H⋯O hydrogen bonding exists between the carbonyl moiety and the aryl hydroxyl group at C5. In both enantiomers, a favorable mutual orientation of two independent molecules promotes the formation of intermolecular O-H⋯O hydrogen bonds that link them into dimers. There are additional long-range intermolecular O-H⋯O hydrogen bonds and weak C-H⋯O contacts within the unit cell of each enantiomer that connect dimers in an extended network. DFT calculations have been performed and the thermodynamics for naringenin racemization via an acyclic chalcone have been computed. Eight energetically accessible conformations have been verified for S-naringenin.

  20. 5-7 Year Old Children's Conceptions of Behaving Artifacts and the Influence of Constructing Their Behavior on the Development of Theory of Mind (ToM) and Theory of Artificial Mind (ToAM)

    Science.gov (United States)

    Spektor-Precel, Karen; Mioduser, David

    2015-01-01

    Nowadays, we are surrounded by artifacts that are capable of adaptive behavior, such as electric pots, boiler timers, automatic doors, and robots. The literature concerning human beings' conceptions of "traditional" artifacts is vast, however, little is known about our conceptions of behaving artifacts, nor of the influence of the…

  1. 4,5,7,8,17-Pentahydroxy-14,18-dimethyl-6-methylene-3,10-dioxapentacyclo[9.8.0.01,7.04,19.013,18]nonadec-14-ene-9,16-dione methanol solvate dihydrate

    Directory of Open Access Journals (Sweden)

    Chin Hoe Teh

    2009-04-01

    Full Text Available The title quassinoid compound, C20H24O9·CH3OH·2H2O, is a natural eurycomanone isolated from the roots of Eurycoma longifolia. The molecules contain a fused five-ring system, with one tetrahydrofuran ring adopting an envelope conformation, one tetrahydropyran-2-one ring in a screw boat conformation, one cyclohexenone ring in a half-chair conformation and two cyclohexane rings in chair conformations. Intramolecular C—H...O interactions generate S(5 ring motifs and an O—H...O interaction generates an S(7 ring motif. In the crystal, molecules are linked via intermolecular O—H...O interactions along the b axis and further stacked along a axis. The absolute configuration of the title compound was inferred from previously solved structures of its analogues.

  2. Methyl 5,7-dihydroxy-2,2,9-trimethyl-6,11-dioxo-6,11-dihydro-2H-anthra[2,3-b]pyran-8-carboxylate

    Directory of Open Access Journals (Sweden)

    Annelise Lobstein

    2008-12-01

    Full Text Available The title compound, C22H18O7, also known as laurentiquinone B, is a new anthraquinone which was isolated from Vismia laurentii, a Cameroonian medicinal plant. The asymmetric unit contains two independent molecules. Each of them contains four fused rings, three of which are coplanar and typical of anthracene, while the heterocyclic rings adopt envelope conformations. Intramolecular O—H...O hydrogen bonds result in the formation of two planar rings, which are also almost coplanar with the adjacent rings. In the crystal structure, intermolecular O—H...O and C—H...O hydrogen bonds link the molecules and a π–π contact is also present [centroid-centroid distance = 3.967 (3 Å].

  3. Synthesis and crystal structure of N-(4-chloro­phen­yl)-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-amine

    Science.gov (United States)

    Repich, Hlib; Orysyk, Svitlana; Savytskyi, Pavlo; Pekhnyo, Vasyl

    2017-01-01

    The title compound, C13H12ClN5, was synthesized by the cyclization of 1-(4,6-di­methyl­pyrimidin-2-yl)-4-phenyl­thio­semicarbazide in the presence of Ni(NO3)2. The mol­ecular structure of the compound is essentially planar. In the crystal, mol­ecules form dimers via pairs of N—H⋯N hydrogen bonds between the H atom of the exocyclic amino group and the N atom at the 4-position of the triazole ring. The resulting dimers are packed into layers which are connected by π-stacking inter­actions between the aromatic systems of the pyrimidine and benzene nuclei, and between the triazole cores. PMID:28083130

  4. Electron delocalization in polyenes: a semiexperimental equilibrium structure for (3E)-1,3,5-hexatriene and theoretical structures for (3Z,5Z)-, (3E,5E)-, and (3E,5Z)-1,3,5,7-octatetraene.

    Science.gov (United States)

    Craig, Norman C; Demaison, Jean; Groner, Peter; Rudolph, Heinz Dieter; Vogt, Natalja

    2015-01-08

    Electronic structure theory reveals that π-electron delocalization increases with the chain length in polyenes. To analyze quantitatively this effect a semiexperimental equilibrium structure has been determined for trans-hexatriene by the mixed estimation method. For this fit rotational constants for a number of carbon and hydrogen isotopologues as well as a high-level ab initio structure have been used. The accuracy is 0.001 Å for bond lengths and 0.1° for bond angles. For the three isomers of octatetraene, high-level ab initio calculations have given a comparably accurate structure. These structures have been used in comparison with the structure of s-trans-butadiene to show that "C═C" bonds increase in length and "C-C" bonds decrease in length as the polyene chain lengthens. These structural effects of π-electron delocalization increase toward the center of polyenes. Most likely, π-π conjugation in the molecules studied plays a large part in their planarity that, in turn, forces the hydrogen atoms of cis fragments in bay regions to be in a close contact. Their distance is indeed shorter than the sum of their van der Waals radii, and they seem to participate in a six-membered ring.

  5. (E-N-[2-(9-Fluorenylidene-3a,5,7-trimethyl-3,3a-dihydro-2H-indol-3-ylidene]-2,4,6-trimethylaniline

    Directory of Open Access Journals (Sweden)

    Norihiro Tokitoh

    2008-02-01

    Full Text Available The title compound, C33H30N2, has an E configuration at the imine double bond. The angle between the least-squares planes of the imine C=N—C group and the benzene ring of the 2,4,6-trimethylphenyl substituent is 85.38 (11°. The crystal structure is sustained mainly by intermolecular π–π interactions (3.510 Å between the two fluorene rings and some C—H...π interactions.

  6. Kiusaaminen ja sen ehkäisy päiväkodissa: työntekijöiden ja 5-7-vuotiaiden lasten näkemyksiä

    OpenAIRE

    Minkkinen, Laura

    2013-01-01

    Opinnäytetyöni aiheena oli kiusaaminen ja sen ehkäisy päiväkodissa. Valitsin aiheen, koska se on mielestäni kiinnostava ja ajankohtainen: tutkimusten mukaan kiusaaminen on jatkuvasti lisääntynyt, eikä sen ehkäisemiseksi ole löydetty tehokkaita menetelmiä. Kiusaamista on tutkittu paljon, mutta vasta viime vuosina on nostettu esiin pienten lasten kiusaaminen. Näin ajankohtaiseksi on myös noussut kiusaamisen ehkäiseminen, joka voidaan aloittaa jo varhaiskasvatuksessa tulevaisuuden asenteiden ...

  7. CCDC 1055681: Experimental Crystal Structure Determination : ((5,7-bis(4'-propylbiphenyl-4-yl)-2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methoxy)acetic acid

    KAUST Repository

    Liu, Ching-Yuan

    2015-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  8. CCDC 1004903: Experimental Crystal Structure Determination : (Di-indeno[2,1-b:1',2'-d]thiene-5,7-diyldiethyne-2,1-diyl)bis(tri-isopropylsilane)

    KAUST Repository

    Shi, Xueliang

    2014-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  9. Comparison of DC and AC Transport in 1.5-7.5 nm Oligophenylene Imine Molecular Wires across Two Junction Platforms: Eutectic Ga-In versus Conducting Probe Atomic Force Microscope Junctions.

    Science.gov (United States)

    Sangeeth, C S Suchand; Demissie, Abel T; Yuan, Li; Wang, Tao; Frisbie, C Daniel; Nijhuis, Christian A

    2016-06-15

    We have utilized DC and AC transport measurements to measure the resistance and capacitance of thin films of conjugated oligophenyleneimine (OPI) molecules ranging from 1.5 to 7.5 nm in length. These films were synthesized on Au surfaces utilizing the imine condensation chemistry between terephthalaldehyde and 1,4-benzenediamine. Near edge X-ray absorption fine structure (NEXAFS) spectroscopy yielded molecular tilt angles of 33-43°. To probe DC and AC transport, we employed Au-S-OPI//GaOx/EGaIn junctions having contact areas of 9.6 × 10(2) μm(2) (10(9) nm(2)) and compared to previously reported DC results on the same OPI system obtained using Au-S-OPI//Au conducting probe atomic force microscopy (CP-AFM) junctions with 50 nm(2) areas. We found that intensive observables agreed very well across the two junction platforms. Specifically, the EGaIn-based junctions showed: (i) a crossover from tunneling to hopping transport at molecular lengths near 4 nm; (ii) activated transport for wires >4 nm in length with an activation energy of 0.245 ± 0.008 eV for OPI-7; (iii) exponential dependence of conductance with molecular length with a decay constant β = 2.84 ± 0.18 nm(-1) (DC) and 2.92 ± 0.13 nm(-1) (AC) in the tunneling regime, and an apparent β = 1.01 ± 0.08 nm(-1) (DC) and 0.99 ± 0.11 nm(-1) (AC) in the hopping regime; (iv) previously unreported dielectric constant of 4.3 ± 0.2 along the OPI wires. However, the absolute resistances of Au-S-OPI//GaOx/EGaIn junctions were approximately 100 times higher than the corresponding CP-AFM junctions due to differences in metal-molecule contact resistances between the two platforms.

  10. A Book of Abstracts for the 2005 Underwater Acoustic Signal Processing Workshop held October 5-7, 2005 at Alton Jones Campus, University of Rhode Island, West Greenwich, Rhode Island, USA

    Science.gov (United States)

    2005-10-07

    these past 37 years Dr. Owsley has established himself as one of the driving forces in advancing the state-of-the- art in underwater acoustic array... Latt , RPS Program Manager, DARPA Advanced Technology Officel -20- Session E, Thursday Afternoon, 1:00pm-2:45pm Presentation E-2 Simulation of Adaptive

  11. Cooperative research project Amax Oil and Gas Inc., Southern UTE No. 5-7 well, San Juan Basin, Southwestern Colorado. Western cretaceous coal seam project. Topical report, September 1992-January 28, 1994

    Energy Technology Data Exchange (ETDEWEB)

    Logan, T.L.; Robinson, J.R.; Pratt, T.J.

    1995-06-01

    A cooperative research effort was performed on one Fruitland coal gas well with AMAX Oil and Gas Inc. The well is located along the western margin of the San Juan basin where both hydraulic fracture and openhole cavity completion techniques have been used. The objective of the research effort was to: (1) determine the reservoir characteristics (gas content, sorption isotherm, absolute permeability, and reservoir pressure) of a shallow Fruitland coal interval, (2) evaluate the effectiveness of the openhole cavity completion technique in the reservoir, and (3) compare the results of this openhole cavity completed well to offset hydraulic fracture completed wells.

  12. CCDC 1055679: Experimental Crystal Structure Determination : (5,7-bis(4'-propylbiphenyl-4-yl)-2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methanol

    KAUST Repository

    Liu, Ching-Yuan

    2015-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  13. CCDC 1055680: Experimental Crystal Structure Determination : 1,1'-((2-(hydroxymethyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5,7-diyl)di-4,1-phenylene)diethanone

    KAUST Repository

    Liu, Ching-Yuan

    2015-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  14. Kas keegi vajab neid raamatuid? / Jaanika Palm

    Index Scriptorium Estoniae

    Palm, Jaanika

    2001-01-01

    Rets. rmt. : Müürsepp, Mare. Kolm põrsakest. Punamütsike : muinasjutu-kirjavihik 5-aastastele lastele. 1 vihik / jutustanud, luuletanud ja ülesanded välja mõelnud Mare Müürsepp. Tallinn : Ilo, 2000. Sari "Muinasjutt õpetab" : Hans ja Grete / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2001; Hunt ja seitse kitsetalle / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2000; Lumivalgeke ja seitse pöialpoissi / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2001; Pöial-Liisi / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2000

  15. Euroopa keelemapi esimene Eesti mudel / Tõnu Tender

    Index Scriptorium Estoniae

    Tender, Tõnu, 1965-

    2008-01-01

    Väljaanne: Euroopa keelemapp : 12-16 aastastele õpilastele = European language portfolio : for learners aged 12 to 16 = Portfolio Européen des Langues : pour les élèves de 12 à 16 ans. [Tartu] : Haridus- ja Teadusministeerium ; [Tallinn] : Eesti Keele Sihtasutus, [2007]. Euroopa keelemapp on vahend keeleõppe kavandamiseks, edusammude kirjeldamiseks ja tulemuste jäädvustamiseks. Keelemapi kirjeldus, Euroopa keelemapi Eesti variandi väljatöötamisest, Euroopa keelemapi tulevikuvõimalustest

  16. Euroopa keelemapi esimene Eesti mudel / Tõnu Tender

    Index Scriptorium Estoniae

    Tender, Tõnu, 1965-

    2008-01-01

    Väljaanne: Euroopa keelemapp : 12-16 aastastele õpilastele = European language portfolio : for learners aged 12 to 16 = Portfolio Européen des Langues : pour les élèves de 12 à 16 ans. [Tartu] : Haridus- ja Teadusministeerium ; [Tallinn] : Eesti Keele Sihtasutus, [2007]. Euroopa keelemapp on vahend keeleõppe kavandamiseks, edusammude kirjeldamiseks ja tulemuste jäädvustamiseks. Keelemapi kirjeldus, Euroopa keelemapi Eesti variandi väljatöötamisest, Euroopa keelemapi tulevikuvõimalustest

  17. Kas keegi vajab neid raamatuid? / Jaanika Palm

    Index Scriptorium Estoniae

    Palm, Jaanika

    2001-01-01

    Rets. rmt. : Müürsepp, Mare. Kolm põrsakest. Punamütsike : muinasjutu-kirjavihik 5-aastastele lastele. 1 vihik / jutustanud, luuletanud ja ülesanded välja mõelnud Mare Müürsepp. Tallinn : Ilo, 2000. Sari "Muinasjutt õpetab" : Hans ja Grete / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2001; Hunt ja seitse kitsetalle / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2000; Lumivalgeke ja seitse pöialpoissi / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2001; Pöial-Liisi / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2000

  18. Anakronistlik popkunstilaine Tartus / Margus Kiis

    Index Scriptorium Estoniae

    Kiis, Margus

    2011-01-01

    Tartu Lastekunstikooli õpetajate näitus "Alla 14aastastele keelatud!" 1.-25. veebruarini ning Kalju Küti ja tema õpilaste näitus "Ühepajatoit" 18. märtsini Tartu Lastekunstikooli galeriis. Kursi koolkonna näitus "Kursi Koolkond XXIII" ja Nadežda Tšernobai näitus "Altarid" Tartu Kunstimajas 20. märtsini. Rait Rosina, Mari-Liis Eskussoni ja Anu Vase näitus "Põikajake ja prügihunt" Y-galeriis 19. märtsini 2011

  19. Õpime eesti keelt mängides

    Index Scriptorium Estoniae

    2015-01-01

    Tutvustus: Kask, Maria. Õpime eesti keelt mängides : eesti keele tööraamat 3–5-aastastele vene mudilastele = Эстонский язык - учимся, играя : уроки эстонского языка для детей 3-5 лет. Tallinn, 2013

  20. Human Performance Enhancement for NATO Military Operations (Science, Technology and Ethics) (Amelioration des performances humaines dans les operations militaires de l’OTAN (Science, Technologie et Ethique)). RTO Human Factors and Medicine Panel (HFM) Symposium held in Sofia, Bulgaria, on 5-7 October 2009

    Science.gov (United States)

    2009-10-01

    du personnel et des unités, en matière de performances. • L’OTAN devrait établir un programme de gestion des connaissances exploitant les schémas en...vigueur concernant la santé et la performance dans les conflits actuels et passés et dans les exercices afin d’orienter les programmes de recherche

  1. Crystal structure of methyl (3RS,4SR,4aRS,11aRS,11bSR-5-oxo-3,4,4a,5,7,8,9,10,11,11a-decahydro-3,11b-epoxyazepino[2,1-a]isoindole-4-carboxylate

    Directory of Open Access Journals (Sweden)

    Flavien A. A. Toze

    2015-10-01

    Full Text Available The title compound, C15H19NO4, is the a product of the esterification of the corresponding carbonic acid with methanol. The molecule comprises a fused tetracyclic system containing three five-membered rings (2-pyrrolidinone, tetrahydrofuran and dihydrofuran and one seven-membered ring (azepane. The five-membered rings have the usual envelope conformations, with the quaternary C atom being the flap atom for the 2-pyrrolidinone ring, and the ether O atom being the common flap atom for the remaining rings. The seven-membered azepane ring adopts a chair conformation with the methine and middle methylene C atoms lying above and below the mean plane defined by the remaining five atoms. The carboxylate substituent is rotated by 77.56 (5° with respect to the base plane of the tetrahydrofuran ring. In the crystal, the molecules are bound by weak C—H...O hydrogen-bonding interactions into puckered layers parallel to (001.

  2. 2,25-Dioxo-27,28-diphenyl-30-oxa-29-thia-3,10,17,24-tetraazapentacyclo[24.2.1.112,15.04,9.018,23]triaconta-5,7,9(4,10,12,14,16,18,20,22,26,28-dodecaene chloroform disolvate

    Directory of Open Access Journals (Sweden)

    Victor N. Khrustalev

    2010-03-01

    Full Text Available The macrocycle of the title compound, C36H24N4O3S·2CHCl3, contains a rigid framework with the nitrogen and oxygen heteroatoms pointing in towards the center of the macrocyclic cavity. The macrocycle is essentially planar (r.m.s. deviation = 0.027 Å except for the thiophene ring. The dihedral angle between the thiophene ring plane and the mean plane of the central macrocyclic core including all atoms except sulfur is 21.6 (1°. Four intramolecular hydrogen bonds occur: two are between the amide hydrogen atoms and the Schiff base nitrogen atoms, while the others are between the amide hydrogen atoms and the sulfur atom of the thiophene. The two solvate chloroform molecules are bound to the carbonyl oxygen atoms of the ligand by weak C—H...O hydrogen bonding. In addition, the structure reveals intermolecular Cl...Cl close contacts [3.308 (2, 3.404 (2 and 3.280 (2 Å] between the chloroform solvate molecules. In the crystal, the macrocycles form layers parallel to (101, with an interlayer distance of 3.362 (3 Å. This short distance is determined by the stacking interactions between the amide carbonyl and imine fragments of neighboring ligands.

  3. 2,9,12,15,18,25,27,34,37,40,43,50-Dodecaoxa-56-azaheptacyclo[24.24.5.151,55.03,8.019,24.028,33.044,49]hexapentaconta-3,5,7,19(24,20,22,28(33,29,31,44,46,48,51,53,55-pentadecaene

    Directory of Open Access Journals (Sweden)

    Jun Hee Kim

    2012-10-01

    Full Text Available The title compound, C43H45NO12, was prepared from the reaction of 2,6-bis(dibromomethylpyridine and bisphenol in the presence of caesium carbonate as a base. The central ring makes dihedral angles of 64.83 (6, 13.48 (6, 56.96 (6 and 66.21 (6° with the peripheral rings. In the crystal, molecules are linked by weak C—H...O and C—H...π interactions, forming a folded structure.

  4. 5.7  W cw single-frequency laser at 671  nm by single-pass second harmonic generation of a 17.2  W injection-locked 1342  nm Nd : YVO4 ring laser using periodically poled MgO : LiNbO3.

    Science.gov (United States)

    Koch, Peter; Ruebel, Felix; Bartschke, Juergen; L'huillier, Johannes A

    2015-11-20

    We demonstrate a continuous wave single-frequency laser at 671.1 nm based on a high-power 888 nm pumped Nd:YVO4 ring laser at 1342.2 nm. Unidirectional operation of the fundamental ring laser is achieved with the injection-locking technique. A Nd:YVO4 microchip laser serves as the injecting seed source, providing a tunable single-frequency power of up to 40 mW. The ring laser emits a single-frequency power of 17.2 W with a Gaussian beam profile and a beam propagation factor of M2beam profile and a beam propagation factor of M2lasers. This work opens possibilities in cold atoms experiments with lithium, allowing the use of larger ensembles in magneto-optical traps or higher diffraction orders in atomic beam interferometers.

  5. 五甲基槲皮素对行颈静脉移植的心肌重构大鼠的治疗作用%Treatment of 3,3',4',5,7-Pentamethylquercetin for myocardial remodeling rat with jugular Vein graft

    Institute of Scientific and Technical Information of China (English)

    毛张凡; 徐小惠; 黄杰; 耿庆

    2012-01-01

    目的 研究五甲基槲皮素(PMQ)对行自体颈静脉移植的心肌重构大鼠模型的治疗作用.方法 30只SD大鼠随机分为模型组、溶剂组和治疗组,建立大鼠颈部自体静脉移植模型后,每晨分别给予生理盐水、溶剂和25 mg/kg PMQ灌胃,均于第15天开始皮下注射血管紧张素Ⅱ[Ang Ⅱ,288 μg/(kg·d)],于21 d后取材.测量心脏指数、左心指数,测量心肌羟脯氨酸含量,免疫组化测量胶原I、Ⅲ容积分数(CVF)比值CVF I/Ⅲ;测量新生内膜和中膜的厚度比及面积比.结果 PMQ能显著抑制心肌的肥厚及纤维化,并能抑制移植静脉内膜的增生,而溶剂则无此作用.结论 PMQ对心肌重构及移植静脉内膜增生均有改善作用,有潜力成为冠状动脉旁路移植术(CABG)术后的治疗药物.%Objective To investigate the treatment effect of Pentamethylquercetin (PMQ) on Ang Ⅱ induced cardiac remodeling rats with jugular vein graft. Methods 30 SD rats were randomly assigned to 3 groups with 10 rals in each group. Reversed jugular vein was implanted into the carotid artery and Angiotensin Ⅱ [Ang Ⅱ , 288 μg/(kg-d)] was injected sub-culaneously daily from the 15i.h day in all rats. Saline, solvent and PMQ (25 mg/kg) were administrated daily via gavage for 21 days in control group, solvent group and PMQ treatment group. The rats were euthanized on the 21st day, the vein grafts and hearts were harvested. The heart weigh! index and the left ventricular weight index were measured; myocardial hydrox-yproline content was measured; CVF Ⅰ /Ⅲ was calculated; intimal hypcrplasia of ihe vein grafts was assessed. Results Myocardial hypertrophy and fibrosis were decreased by PMQ and intimal hyperplasia was reduced, the effect was not found in solvent Conclusion PMQ can improve the cardiac remodeling and neoinlima hyperplasia of vein graft, so PMQ has the potential to therapy patients with coronary heart disease that have accepted coronary artery bypass grafting iCABG).

  6. Crystal structure of poly[[aqua­(μ-2,3-di­hydro­thieno[3,4-b][1,4]dioxine-5,7-di­carboxyl­ato-κ2 O 5:O 7)[μ-di(pyridin-4-yl)sulfane-κ2 N:N′]zinc] 0.26-hydrate

    Science.gov (United States)

    Wu, Wen-Liang; Hu, Bing

    2017-01-01

    The crystal structure of the title polymer, {[Zn(C8H4O6S)(C10H8N2S)(H2O)]·0.26H2O}n, is characterized by a layered arrangement parallel to the ab plane. The zinc cation is five-coordinated in a slightly distorted trigonal–bipyramidal coordination environment defined by two pyridine ligands, two carboxyl­ate groups of two thio­phene di­carboxyl­ate ligands, and by one water mol­ecule. The ethyl­ene bridge in the dioxine ligand is disordered over two sets of sites [occupancy ratio 0.624 (9):0.376 (9)]. Several hydrogen-bonding inter­actions of the types O—H⋯O, C—H⋯O, C—H⋯S and C—H⋯N ensure the cohesion within the crystal structure.

  7. Bis(5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-κ4N(μ-l-malato-κ4O1,O2:O4,O4′dinickel(II bis(perchlorate monohydrate

    Directory of Open Access Journals (Sweden)

    Guang-Chuan Ou

    2009-07-01

    Full Text Available In the crystal structure of the title dinuclear compound, [Ni2(C4H4O5(C16H36N42](ClO42·H2O, the bridging dicarboxylate dianion O,O′-chelates to two Ni atoms, both of which are also chelated by the N-macrocylic ligand. The Ni atoms exhibit a distorted octahedral coordination. N—H...O and O—H...O hydrogen bonds link the cations and the uncoordinated water molecules into a layer structure; the perchlorate anions occupy the space between adjacent layers, and are only weakly linked to the layers. One of the perchlorate anions is disordered over two sets of sites in a 3:2 ratio.

  8. 细胞凋亡及p5 3基因的表达在C5 7BL/6N系小鼠腭裂形成中的意义%The significance of PCD and mRNA transcription of p53 gene during development of normal palate and cleft palate in C57BL/6N mouse

    Institute of Scientific and Technical Information of China (English)

    李鑫; 金岩; 董绍忠; 朱萧玲

    2000-01-01

    Objectives :To observe the difference of programmed cell death (PCD) and the expression of related gene p53 in the development of normal palate and in the formation of cleft palate. Methods:The model of the development of cleft palat was estabished with retinoid acid (80 mg · kg-1 for each pregnant mouse). The palate samples were obtained at GD1314(at 13rd day 14 hours of prenancy) ,1322,148 ,1414,1433 ,158 ,1522 and 168 respectively. PCD was detected with TUNEL staining,while the mRNA transcription of p53 was observed by in situ hybridization. Rssults:In early development of palate process, the positive index of PCD in the cleft palate samples was significantly higher than that in the normal (P<0.01). But no difference was observed in the expression of p53 (P>0.05) between the two groups. Conclusion:The proliferation of mesenchymal cells of the early developmental palate process may be inhibited due to the abnomal PCD in the formation of cleft palate. The mechanism of PCD in this study may be a p53-independed pathway.%目的:探讨细胞程序性死亡和相关基因p53的表达变化在腭裂发生中的意义。方法:利用建立的腭裂模型,采用原位末端转移酶标记法(TUNEL)和基因探针原位杂交法,原位观察了二种阳性信号的表达。结果:实验组小鼠腭突发育的垂直期、上抬期中细胞程序性死亡明显多于对照组(P<0.01)。但两组间p53 mRNA转录水平的变化均无明显差异(P>o.05)。对照组小鼠生长早期p53基因的表达高于同组融合期的腭突。结论:在腭突发育时期出现超出生理范围的细胞程序死亡,影响腭突以后形态、体积的发育,与腭裂形成有密切关系。p53基因在两组中表达无明显变化,提示腭突间充质细胞的程序性死亡,可能是通过非p53依赖途径发生的。

  9. 5,7,13,15-Tetraoxo-2,2,10,10-tetrakis(trifluoromethyl-4,8,12,16-tetraoxa-1(1,4,3(1,4,6(1,2,9(1,4,11(1,4,14(1,2-hexabenzenahexadecaphane tetrahydrofuran monosolvate

    Directory of Open Access Journals (Sweden)

    Qing-Zhong Guo

    2012-04-01

    Full Text Available The title compound, C46H24F12O8·C4H8O, consists of a cyclic aryl ester dimer and a tetrahydrofuran molecule. In the structure of the cyclic dimer, one carbonyl group stretches above the cavity and the other below.

  10. Crystal structure of 2-isopropyl-5,7′-dimethyl-1′,3′,3a',6′,8a',8b'-hexahydrospiro[cyclohexane-1,6′-furo[3,4-d]imidazo[1,5-b]isoxazol]-8′(7′H-one

    Directory of Open Access Journals (Sweden)

    Heithem Abda

    2016-08-01

    Full Text Available In the title compound, C17H28N2O3, the isoxazolidine ring adopts an envelope conformation with the O atom deviating from the mean plane of the other four ring atoms by 0.617 (1 Å. In the crystal, molecules are linked via weak C—H...O hydrogen bonds, forming chains which extend along the b-axis direction.

  11. 5.7. К ВОПРОСУ ОБ ОГРАНИЧЕНИИ ПРИМЕНЕНИЯ УСЛОВНОГО ОСУЖДЕНИЯ ЗА КВАЛИФИЦИРОВАННОЕ ВЗЯТОЧНИЧЕСТВО

    OpenAIRE

    Дмитриева, Анна

    2010-01-01

    В статье рассматриваются некото-рые аспекты современных тенденций развития рос-сийского уголовного законодательства, регламен-тирующего ответственность за взяточничество, а также антикоррупционного законодательства в це-лом. Обосновывается необходимость совершенст-вования соответствующих положений Уголовного кодекса РФ и практики их применения....

  12. Dicty_cDB: Contig-U16228-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1 ( AY960305 ) Erebia triaria haplotype ET14 cytochrome oxidase ... 46 5.7 1 ( AY754686 ) Harpagoxenus subla...evis haplotype L cytochrome oxi... 46 5.7 1 ( AY754685 ) Harpagoxenus sublaevis h...aplotype K cytochrome oxi... 46 5.7 1 ( AY754684 ) Harpagoxenus sublaevis haplotype J cytochrome oxi... 46 5.7 1 ( AY754683 ) Harpago...xenus sublaevis haplotype I cytochrome oxi... 46 5.7 1 ( AY754682 ) Harpagoxenus su...blaevis haplotype H cytochrome oxi... 46 5.7 1 ( AY754681 ) Harpagoxenus sublaevis haplotype G cytochrome ox

  13. Field Analysis and Potential Theory

    Science.gov (United States)

    1985-06-01

    T T T 430 FIELD ANALYSIS AND POTENTIAL THEORY [Sec.5.7 But V2f [ dT - Z j V2 Jxdr T T hence V c2at 7- dT _- J2 (J2 dT T TT whence dalf [13 dT " 0 (5.7...8) at exterior points or dal pot [2] - O (5.7-8(a)) Similarly, dalf r dS - 0 (5.7-9) dal [y] ds - 0 (5.7-10) r Sec.5.7] RETARDED POTENTIAL THEORY 431

  14. Depletion of Serotonin Selectively Impairs Short-Term Memory without Affecting Long-Term Memory in Odor Learning in the Terrestrial Slug "Limax Valentianus"

    Science.gov (United States)

    Santa, Tomofumi; Kirino, Yutaka; Watanabe, Satoshi; Shirahata, Takaaki; Tsunoda, Makoto

    2006-01-01

    The terrestrial slug "Limax" is able to acquire short-term and long-term memories during aversive odor-taste associative learning. We investigated the effect of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) on memory. Behavioral studies indicated that 5,7-DHT impaired short-term memory but not long-term memory. HPLC…

  15. Methylenedioxy- and methoxyflavones from Melicope coodeana syn. Euodia simplex

    DEFF Research Database (Denmark)

    Simonsen, Henrik Toft; Larsen, Michael D; Nielsen, Merete W;

    2002-01-01

    Three new natural products, 3,8-dimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone, 3,6,8-trimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone and 3,6,8,3',4'-pentamethoxy-5,7-dihydroxyflavone were isolated from Melicope coodeana syn. Euodia simplex (Rutaceae) along with 3,6,3'-trimethoxy-5...

  16. Depletion of Serotonin Selectively Impairs Short-Term Memory without Affecting Long-Term Memory in Odor Learning in the Terrestrial Slug "Limax Valentianus"

    Science.gov (United States)

    Santa, Tomofumi; Kirino, Yutaka; Watanabe, Satoshi; Shirahata, Takaaki; Tsunoda, Makoto

    2006-01-01

    The terrestrial slug "Limax" is able to acquire short-term and long-term memories during aversive odor-taste associative learning. We investigated the effect of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) on memory. Behavioral studies indicated that 5,7-DHT impaired short-term memory but not long-term memory. HPLC…

  17. Dicty_cDB: Contig-U13032-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available bipunctata host, strain Z) ... 44 5.7 1 ( AF539861 ) Wolbachia endosymbiont of Aphthona nigriscutis cl... 4...4 5.7 1 ( AF539860 ) Wolbachia endosymbiont of Aphthona nigriscutis cl... 44 5.7 1 ( AF481168 ) Wolbachia pi

  18. Geranylated flavanones from the secretion on the surface of the immature fruits of Paulownia tomentosa.

    Science.gov (United States)

    Asai, Teigo; Hara, Noriyuki; Kobayashi, Sawa; Kohshima, Shiro; Fujimoto, Yoshinori

    2008-03-01

    Chemical investigation of the methanol extract of the viscous secretion on the surface of immature fruits of Paulownia tomentosa furnished nine geranylated flavanones, 6-geranyl-5,7-dihydroxy-3',4'-dimethoxyflavanone (1), 6-geranyl-3',5,7-trihydroxy-4'-methoxyflavanone (2), 6-geranyl-4',5,7-trihydroxy-3',5'-dimethoxyflavanone (3), 6-geranyl-4',5,5',7-tetrahydroxy-3'-methoxyflavanone (4), 6-geranyl-3,3',5,7-tetrahydroxy-4'-methoxyflavanone (5), 4',5,5',7-tetrahydroxy-6-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]-3'-methoxyflavanone (6), 3,3',4',5,7-pentahydroxy-6-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]flavanone (7), 3,3',4',5,7-pentahydroxy-6-[7-hydroxy-3,7-dimethyl-2(E)-octenyl]flavanone (8), and 3,4',5,5',7-pentahydroxy-3'-methoxy-6-(3-methyl-2-butenyl)flavanone (9), along with six known geranylated flavanones. Among these, compounds 4, 6-9 and the known 6-geranyl-3',4',5,7-tetraahydroxyflavanone (diplacone), 6-geranyl-3,3',4',5,7-pentahydroxyflavanone (diplacol) and 3',4',5,7-pentahydroxy-6-[7-hydroxy-3,7-dimethyl-2(E)-octenyl]flavanone showed potent radical scavenging effects towards DPPH radicals.

  19. Dicty_cDB: Contig-U11186-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 57082 ) Sequence 7902 from Patent WO0157270. 46 5.7 1 ( CQ052063 ) Sequence 2883 from Patent WO0157270. 46 5.7 1 ( BD345387 ) BREAST..., GASTRIC, AND PROSTATE CANCER ASSOCIATED A... 46 5.7 1 ( BD345291 ) BREAST, GASTRIC

  20. Dicty_cDB: Contig-U04565-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 210774231 NGP Nasonia giraulti cDNA clone 178C7 5... 44 5.7 1 ( EV417270 ) 210763534 NGP Nasonia giraulti cD...NA clone 154C3 5... 44 5.7 1 ( EV414825 ) 210738322 NGP Nasonia giraulti cDNA clo...ne 147K21 ... 44 5.7 1 ( ES622302 ) NGPEO24TR NGPA Nasonia giraulti cDNA, mRNA sequence. 44 5.7 1 ( ES620616... ) NGPDO77TR NGPA Nasonia giraulti cDNA, mRNA sequence. 44 5.7 1 ( ES617091 ) NGPBO86TR NGPA Nasonia girault...root ti... 44 5.7 1 ( EV583387 ) Dmel_dig_009967_0599_0915 D. melanogaster - 454 s... 44 5.7 1 ( EV418832 )

  1. Isoflavanones and their O-glycosides from Desmodium styracifolium.

    Science.gov (United States)

    Zhao, Ming; Duan, Jin-Ao; Che, Chun-Tao

    2007-05-01

    Two isoflavanones (5,7-dihydroxy-2',3',4'-trimethoxy-isoflavanone and 5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxy-isoflavanone), four isoflavanone O-glycosides (5,7-dihydroxy-2',3',4'-trimethoxy-isoflavanone 7-O-beta-glucopyranoside, 5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxy-isoflavanone 7-O-beta-glucopyranoside, 5,7-dihydroxy-2',4'-dimethoxy-isoflavanone 7-O-beta-glucopyranoside, and 5,7,4'-trihydroxy-2',3'-dimethoxy-isoflavanone 7-O-beta-glucopyranoside), and a coumaronochromone (3,5,7,4'-tetrahydroxy-coumaronochromone), along with 25 known compounds, were isolated from the aerial parts of Desmodium styracifolium. This is for the first time isoflavanone O-glycosides were isolated from a natural source.

  2. Environmental and Water Quality Operational Studies. Environmental Guidelines for Dike Fields.

    Science.gov (United States)

    1984-09-01

    oak ( Quercus alba) 12.5 7.0 Douglas fir (Pseudotsuga taxifolia) 12.5 7.0 Bald cypress (Taxodium distichum) 12.5 7.0 _ * Norway pine (Pinus resinosa...Rier• inc al the¢’.. -.elW~~;. W .- W W.V-W W dikes~ ~ ~ ~ ~ ~ ~ ~ ~ ~~~~’ are subered none spreve o ot sd kes Sme’’.. • -. Increase in width due to

  3. Diversity and antimicrobial susceptibility of Salmonella enterica serovars isolated from pig farms in Ibadan, Nigeria

    DEFF Research Database (Denmark)

    Fashae, Kayode; Hendriksen, Rene S.

    2014-01-01

    reaction. The 229 Salmonella isolates were made of 50 serovars predominated by rare serovars Salmonella Give (n = 36; 15.7 %), Salmonella Brancaster (n = 17; 7.4 %), Salmonella Colindale (n = 15; 6.6 %), Salmonella Elisaberthville (n = 13; 5.7 %), Salmonella Hillingdon (n = 13; 5.7 %), and Salmonella...

  4. 77 FR 65732 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change and...

    Science.gov (United States)

    2012-10-30

    ... certificates, futures or other financial instruments that represent platinum or palladium or that may be... instruments that represent platinum or palladium or that may be exchanged for platinum or palladium and will... 5.7(2) and 5.7(3) of National Instrument 81- 102,--Mutual Funds, the Trust must apply to the...

  5. Foodborne Illness Retrospective

    Centers for Disease Control (CDC) Podcasts

    2015-05-07

    Dr. Paul Mead and Dr. Peter Drotman discuss the historic October 1999 article, Food-related Illness and Death in the United States.  Created: 5/7/2015 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 5/7/2015.

  6. Take a Walk (A Minute of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2015-05-07

    Arthritis is among the most common chronic condition in the U.S., affecting more than 52 million adults. This podcast discusses the importance of exercise for those diagnosed with arthritis.  Created: 5/7/2015 by MMWR.   Date Released: 5/7/2015.

  7. Take a Walk (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2015-05-07

    Arthritis is among the most common chronic conditions in the U.S., affecting more than 52 million adults. In this podcast, Dr. Charles Helmick discusses ways to manage arthritis.  Created: 5/7/2015 by MMWR.   Date Released: 5/7/2015.

  8. Vital Signs – Hepatitis C: What You Need to Know

    Centers for Disease Control (CDC) Podcasts

    2013-05-07

    This podcast is based on the May 2013 CDC Vital Signs report. It discusses hepatitis C, a serious viral infection, and the need for everyone born from 1945 through 1965 to get tested.  Created: 5/7/2013 by Centers for Disease Control and Prevention (CDC).   Date Released: 5/7/2013.

  9. Hepatitis C: What You Need to Know PSA (:60)

    Centers for Disease Control (CDC) Podcasts

    2013-05-07

    This 60 second public service announcement is based on the May 2013 CDC Vital Signs report. It discusses hepatitis C, a serious viral infection, and the need for everyone born from 1945 through 1965 to get tested.  Created: 5/7/2013 by Centers for Disease Control and Prevention (CDC).   Date Released: 5/7/2013.

  10. Dicty_cDB: Contig-U09340-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available olanum lycopersicum cv. Heinz 1706, chromosome 0... 44 5.7 1 ( DD147007 ) A method for assaying an inhibitor...31 ) Vitis vinifera contig VV78X115648.4, whole genome... 44 5.7 1 ( AC212306 ) S

  11. UPTAKE AND TRANSFORMATION OF EXPLOSIVES BY EASTERN COTTONWOOD (POPULUS DELTOIDES)

    Science.gov (United States)

    The explosives 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetraazocine (HMX) have been extensively used by the United States military to manufacture munitions. Since World War II, both the commissioning an...

  12. 78 FR 77005 - Magnuson-Stevens Fishery Conservation and Management Act Provisions; Fisheries of the...

    Science.gov (United States)

    2013-12-20

    ... Quahog Quotas Ocean Quahog Year ABC ACL ACT Commercial quota 2014-2016 5.7 million bu (306 5.7 million bu...) (ACL) (ACT) Commercial quota 2014 7.8 million bu (415 7.8 million bu (415 3.8 million bu (202 3.4... Conservation and Management Act Provisions; Fisheries of the Northeastern United States; Atlantic Surfclam...

  13. Comparison of three approaches for defining nucleus pulposus and annulus fibrosus on sagittal magnetic resonance images of the lumbar spine

    Directory of Open Access Journals (Sweden)

    Greta S.P. Mok

    2016-07-01

    Conclusion: The 5-/7-ROI methods agreed with the M-ROI approach for NP selection, while the agreement with AF was moderate to poor, with the 5-ROI method showing slight advantage over the 7-ROI method. Cautions should be taken to interpret the MR relaxometry findings when 5-/7-ROI methods are used to select AF.

  14. MODULATION OF DEFENSIVE REFLEX CONDITIONING IN SNAILS BY SEROTONIN

    Directory of Open Access Journals (Sweden)

    Vyatcheslav V Andrianov

    2015-10-01

    Full Text Available We studied the role of serotonin in the mechanisms of learning in terrestrial snails. To produce a serotonin deficit, the neurotoxic analogues of serotonin, 5,6- or 5,7-dihydroxytryptamine (5,6/5,7-DHT were used. Injection of 5,6/5,7-DHT was found to disrupt defensive reflex conditioning. Within two weeks of neurotoxin application, the ability to learn had recovered. Daily injection of serotonin before a training session accelerated defensive reflex conditioning and daily injections of 5-HTP in snails with a deficiency of serotonin induced by 5,7-DHT restored the snail’s ability to learn. We discovered that injections of the neurotoxins 5,6/5,7-DHT as well as serotonin, caused a decrease in the resting and threshold potentials of the premotor interneurons LPa3 and RPa3.

  15. Studies on mountain streams in the English lake district I. PH, calcium and the distribution of invertebrates in the River Duddon

    Energy Technology Data Exchange (ETDEWEB)

    Sutcliffe, D.W.; Carrick, T.R.

    1973-01-01

    The River Duddon and its tributaries rarely exceed pH 7.0. There are three types of acid regime; pH>5.7 and pH<5.7 independent of season or rainfall, and fluctuating acidity with pH<5.7 in winter and wet periods, pH>5.7 in summer or dry periods. PH in the River Duddon fluctuates for most of its length. Ph>5.7 is characteristic of tributaries in the lower drainage basin, but pH<5.7 occurs in the headwaters of two of these tributaries. With five exceptions, pH<5.7 or fluctuating pH are characteristic of tributaries in the upper drainage basin. A very close relationship exists between the pH regime of stream water and the benthis cauna. Apart from oligochaetes and flatworms, streams with pH<5.7 or fluctuating pH are characterized by thirteen common or abundant taxa; six plecoptera, four trichoptera and three diptera. These taxa are also common in streams with pH>5.7 but in addition these streams contain ephemeroptera, the trichopterans wormaldia and hydropsyche, the mollusc Ancylus and the amphipod gammarus. It is concluded that the calcium concentration is less important than the pH-bicarbonate concentrations in limiting the qualitative distribution of benthic invertebrates. The limiting effect of pH<5.7 on an extensive range of taxa in the duddon also occurs in other areas. The affected taxa are generally herbivores. It is suggested that in the case of insects the limiting effects of low pH may indirectly operate through changes in food supply.

  16. Metabolism of Kaempferia parviflora polymethoxyflavones by human intestinal bacterium Bautia sp. MRG-PMF1.

    Science.gov (United States)

    Kim, Mihyang; Kim, Nayoung; Han, Jaehong

    2014-12-24

    Poylmethoxyflavones (PMFs) are major bioactive flavonoids, which exhibit various biological activities, such as anticancer effects. The biotransformation of PMFs and characterization of a PMF-metabolizing human intestinal bacterium were studied herein for the first time. Hydrolysis of aryl methyl ether functional groups by human fecal samples was observed from the bioconversion of various PMFs. Activity-guided screening for PMF-metabolizing intestinal bacteria under anaerobic conditions resulted in the isolation of a strict anaerobic bacterium, which was identified as Blautia sp. MRG-PMF1. The isolated MRG-PMF1 was able to metabolize various PMFs to the corresponding demethylated flavones. The microbial conversion of bioactive 5,7-dimethoxyflavone (5,7-DMF) and 5,7,4'-trimethoxyflavone (5,7,4'-TMF) was studied in detail. 5,7-DMF and 5,7,4'-TMF were completely metabolized to 5,7-dihydroxyflavone (chrysin) and 5,7,4'-trihydroxyflavone (apigenin), respectively. From a kinetics study, the methoxy group on the flavone C-7 position was found to be preferentially hydrolyzed. 5-Methoxychrysin, the intermediate of 5,7-DMF metabolism by Blautia sp. MRG-PMF1, was isolated and characterized by nuclear magnetic resonance spectroscopy. Apigenin was produced from the sequential demethylation of 5,7,4'-TMF, via 5,4'-dimethoxy-7-hydroxyflavone and 7,4'-dihydroxy-5-methoxyflavone (thevetiaflavone). Not only demethylation activity but also deglycosylation activity was exhibited by Blautia sp. MRG-PMF1, and various flavonoids, including isoflavones, flavones, and flavanones, were found to be metabolized to the corresponding aglycones. The unprecedented PMF demethylation activity of Blautia sp. MRG-PMF1 will expand our understanding of flavonoid metabolism in the human intestine and lead to novel bioactive compounds.

  17. Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer.

    OpenAIRE

    Wen, Xia; Walle, Thomas

    2007-01-01

    Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: 5,7- dimethoxyflavone (5,7-DMF) and 30,40-dimethoxyflavone (30,40-DMF)Pathways studied: BaP- DNA binding by inhibition of CYP1B1/1A1 activity and/or protein expressionStudy type (in vitro, animals, humans): in vitroImpact on pathway (including dose-response): 5,7-DMF: BaP-DNA binding was markedly inhibited and the BaP-induced part of the CYP1B1 mRNA expression (P

  18. Mikhail Gorbachev’s ’New Thinking’ Implications for Western Security

    Science.gov (United States)

    1991-06-01

    for thf Advancement of Slavic Studies in Boston, MA, 5-7 November 1987. Citation is from p. 3. ’nSee David S. Yost, Soviet Ballistic Missile Defense...of the American Association for the Advancement of Slavic Studies , Boston, MA, 5-7 November 1987. "The New Quality of Soviet Defense." international...Association for the Advancement of Slavic Studies , Boston, MA, 5-7 November, 1987. McConnell, James M. "Reasonable Suffidency" in Soviet Conventional Arms

  19. Flavanonas preniladas de dalea caerulea

    Directory of Open Access Journals (Sweden)

    Alba Isabel Arango

    2010-07-01

    Full Text Available Los compuestos: 5.7-dihidroxi-8-pTenilflavanona; 5,7-dihidr(xi-6-metil-8-brenilflavanoa; 5,7-dihidroxi-6-prenilflavanona; y 5-hidroxi-7-metoxi-8-prenilflavanona fueron aislados por CC guiados por bioeasayos de toxicidad con Artemia salina a partir del extracto en éter de petróleo de la parte aérea de Dalea caerulea e identificados por espectroscopias IR, UV, 'HRMN, "CRMN, y EM. Las flavanonas en estado puro no dieron actividad significativa al bioensayo de toxicidad.

  20. Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin

    Directory of Open Access Journals (Sweden)

    K. H. Hemakumar

    2008-01-01

    Full Text Available The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-2,3-dimethoxy-9-chloro–11bH benzo[C]-fluoren-5,7-dione and 6,6a-dihydro-2,3-dimethoxy-9-fluoro–11bH benzo[C]-fluoren-5,7- dione were synthesized in high yields. They are analogues of naturally occurring lignan podophyllotoxin which exhibits anticancer activity. They are very essential to study anticancer activity.

  1. InterProScan Result: FS898954 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ASSOCIATED PROTEIN 14 5.7e-59 T IPR006709 Small-subunit processome, Utp14 Biological Process: rRNA processing (GO:0006364)|Cellular Component: small-subunit processome (GO:0032040) ...

  2. Teatralnõi adjulter kak osnova semeinogo stshastja

    Index Scriptorium Estoniae

    2006-01-01

    5.-7. juulini toimuvad Estonia teatris Moskva Mossoveti-nim. Teatri külalisetendused. Juri Jerjomini lavastusest "Mees, naine ja armuke" F. Dostojevski ja I. Turgenevi teoste põhjal, peaosas Valentin Gaft

  3. Factors Affecting the Pre-Contract use of the Bill of Quantities | Ogbu ...

    African Journals Online (AJOL)

    ... were architects, 9.4% were civil engineers and 5.7% were mechanical and electrical engineers. The data collected were analysed with the Statistical Package for Social Sciences (SPSS) using descriptive statistics and analysis of variance.

  4. 77 FR 28590 - Combined Notice of Filings #2

    Science.gov (United States)

    2012-05-15

    ... Agreement No. 3282; Queue No. X1-116 to be effective 4/10/2012. Filed Date: 5/7/12. Accession Number..., Dighton Power, LLC, EquiPower Resources Management, LLC, Lake Road Generating Company, L.P.,...

  5. Analysts : no need to panic over prices / Steven Paulikas

    Index Scriptorium Estoniae

    Paulikas, Steven

    2004-01-01

    Pärast EL-iga liitumist on Balti riikides hinnad tõusnud keskmiselt 5,7%, pankade hinnangul on oodata ka inflatsiooni kiirenemist. Lisa: Thank you, accession: Consumer Price Index, percent increase, year-on-year

  6. Monsters in the dark and other scary things: preschoolers' self-reports

    National Research Council Canada - National Science Library

    Loxton, Helene

    2009-01-01

    Objective: This study attempted to obtain normative data regarding the content and frequency of expressed fears of a culturally diverse group of 152 South African preschool children (aged 5-7 years). Method...

  7. K nam prijezzhajet "Tramvai "Zhelanije""...

    Index Scriptorium Estoniae

    2006-01-01

    5.-7. juulini toimuvad Estonia teatris Moskva Mossoveti-nim. Teatri külalisetendused. Juri Jerjomini lavastus Tennessee Williamsi järgi "Tramm nimega Iha" : Blanche - Jevgenija Krjukova ja Stella - Jekaterina Gusseva,

  8. Anti-vibrio potentials of acetone and aqueous leaf extracts of ...

    African Journals Online (AJOL)

    Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 .... with the count of the culture control without ..... Internet J Food Safety 2005; 5(7): 15-19. 20. ... growth of bacterial strains isolated from the patients with.

  9. Neck masses in children: Etiopathology in a tertiary center

    African Journals Online (AJOL)

    2011-02-15

    Feb 15, 2011 ... chemo and/or radiotherapy, with two (5.7%) mortality recorded due ... surgical consultation and thorough histopathologic analysis of neck masses in children in our subregion. ... Anorexia, weight loss, failure to thrive, anemia,.

  10. Determinación de ácidos grasos y compuestos triterpenoides del cuerpo fructifero de suillus luteus.

    OpenAIRE

    Ivonne Nieto; Iris Avila

    2009-01-01

    Del cuerpo fructífero de Suillus luteus se extrajeron e identificaron, con base en el análisis de sus espectros de masas,  dieciséis compuestos, los cuales corresponden al ácido palmítico, oléico, linolénico y linoléico, octadecanoato de etilo, ergosta-7,22-dien-3β-ol, ergosta-7-en-3β-ol, estigmasterol, ergosta-3,5,7,9(11),22-pentaeno, ergosta-2,5,7,9(11),14,22-hexaeno, 23-metil-estigmast-3,5,7,22-tetraeno, 23-metil-estigmast-3,5,7,9(11),22-pentaeno, ergosta-4,6,15(16),22-tetraen-3-ona, ...

  11. Experimental Reservoirs of Human Pathogens: The Vibrio Cholerae Paradigm (7th Annual SFAF Meeting, 2012)

    Energy Technology Data Exchange (ETDEWEB)

    Colwell, Rita [University of Maryland

    2012-06-01

    Rita Colwell on "Experimental Reservoirs of Human Pathogens: The Vibrio cholerae paradigm" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  12. Endosymbiont hunting in the metagenome of Asian citrus psyllid (Diaphorina citri) (7th Annual SFAF Meeting, 2012)

    Energy Technology Data Exchange (ETDEWEB)

    Saha, Surya [Cornell University

    2012-06-01

    Surya Saha on "Endosymbiont hunting in the metagenome of Asian citrus psyllid (Diaphorina citri)" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  13. Finishing and Special Motifs: Lessons Learned from CRISPR Analysis Using Next-Generation Draft Sequences ( 7th Annual SFAF Meeting, 2012)

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Catherine [Noblis

    2012-06-01

    Catherine Campbell on "Finishing and Special Motifs: Lessons learned from CRISPR analysis using next-generation draft sequences" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  14. Tetrakis(dimethoxyphenyl)adamantane (TDA) and its inclusion complexes in the crystalline state: a versatile carrier for small molecules.

    Science.gov (United States)

    Schwenger, Alexander; Frey, Wolfgang; Richert, Clemens

    2015-06-08

    Molecular storage solutions for incorporating small molecules in crystalline matrices are of interest in the context of structure elucidation, decontamination, and slow release of active ingredients. Here we report the syntheses of 1,3,5,7-tetrakis(2,4-dimethoxyphenyl)adamantane, 1,3,5,7-tetrakis(4-methoxyphenyl)adamantane, 1,3,5,7-tetrakis(4-methoxy-2-methylphenyl)adamantane, and 1,3,5,7-tetrakis(4-methoxy-2-ethylphenyl)adamantane, together with their X-ray crystal structures. All four compounds crystallize readily. Only the octaether shows an unusual level of (pseudo)polymorphism in its crystalline state, combined with the ability to include a number of different small molecules in its crystal lattices. A total of 20 different inclusion complexes with guest molecules as different as ethanol or trifluorobenzene were found. For nitromethane and benzene, schemes for uptake and release are presented.

  15. Predictors of eclampsia among preeclamptic patients: a case control study in Yaounde, Cameroon

    Directory of Open Access Journals (Sweden)

    Jeanne Hortence Fouedjio

    2016-07-01

    Conclusions: These predictors of eclampsia can be used for early initiation of aggressive preventive therapy in pre-eclamptic patients. [Int J Reprod Contracept Obstet Gynecol 2016; 5(7.000: 2204-2209

  16. Actively Cooled Silicon Lightweight Mirrors for Far Infrared and Submillimeter Optical Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Schafer proposes to demonstrate 2 different methods for actively cooling our 5-7.5 kg/m2 areal density Silicon Lightweight Mirrors (SLMS?) technology for future NASA...

  17. Evaluación de razones de prevalencia para sedentarismo y factores de riesgo en un grupo de estudiantes universitarios. Chía - Colombia/Evaluation of prevalence reasons for inactivity and risk factors in a group of university students. Chía - Colombia

    National Research Council Canada - National Science Library

    Jorge Enrique Moreno Collazos; Harold Fabián Cruz Bermúdez; Adriana Angarita Fonseca

    2014-01-01

    .... be between 20 and 27 years old increased 2.7 (95% CI 1.2 to 5.7) the prevalence of physical inactivity compared to having between 17 and 19 years adjusted for cardiovascular risk and heart rate...

  18. Collecting succulent plants for deposition in a herbarium

    CSIR Research Space (South Africa)

    Walters, Michele

    2011-06-01

    Full Text Available sheets of drying paper (newspaper, cut to size, works well and is inexpensive) 4. Flimsy (thin, strong, slightly absorbent paper, such as unprinted newspaper) containing a specimen 5. 7ZR...

  19. Finantsjuhtimine raamatukogus. I / Kate-Riin Kont

    Index Scriptorium Estoniae

    Kont, Kate-Riin, 1971-

    2008-01-01

    Järg. nr. 2 lk. 5-7, nr. 3 lk. 5-8. Raamatukogu ressursside paigutamise ja finantsjuhtimise teoreetilised lähtekohad avaliku sektori organisatsioonide kontekstis, finants- ja tulemusjuhtimise suundumused avaliku halduse organisatsioonides

  20. Biodegradable Nanocomposite Films Based on Sodium Alginate and Cellulose Nanofibrils

    National Research Council Canada - National Science Library

    Deepa, B; Abraham, Eldho; Pothan, Laly; Cordeiro, Nereida; Faria, Marisa; Thomas, Sabu

    2016-01-01

    ...) into alginate biopolymer using the solution casting method. The effects of CNF content (2.5, 5, 7.5, 10 and 15 wt %) on mechanical, biodegradability and swelling behavior of the nanocomposite films were determined...

  1. 78 FR 28576 - Notice of Petitions by Firms for Determination of Eligibility To Apply for Trade Adjustment...

    Science.gov (United States)

    2013-05-15

    ... Kimball, NE 69145. electrical components and parts for alarms and security systems. AGY Aiken, LLC 2556 Wagener Road, Aiken, 5/7/2013 The firm produces fiberglass SC 29801. yarns; the primary manufacturing...

  2. Chemical synthesis, characterization and evaluation of antimicrobial properties of Cu and its oxide nanoparticles

    CSIR Research Space (South Africa)

    Motlatle, Abesach M

    2016-10-01

    Full Text Available Cu nanoparticles were synthesized using low-temperature aqueous reduction method at pH 3, 5, 7, 9 and 11 in presence of ascorbic acid and polyvinylpyrrolidone. The nanoparticles were characterized using transmission electron microscopy, scanning...

  3. Analysts : no need to panic over prices / Steven Paulikas

    Index Scriptorium Estoniae

    Paulikas, Steven

    2004-01-01

    Pärast EL-iga liitumist on Balti riikides hinnad tõusnud keskmiselt 5,7%, pankade hinnangul on oodata ka inflatsiooni kiirenemist. Lisa: Thank you, accession: Consumer Price Index, percent increase, year-on-year

  4. 78 FR 57410 - Endangered Species; Issuance of Permits

    Science.gov (United States)

    2013-09-18

    ..., Ecological Services, U.S. Fish and Wildlife Service, Pacific Regional Office, 911 NE 11th Avenue, Portland.../2013 5/7/2017 Naval Facilities Engineering Command Pacific 096741 4/19/2013 4/18/2016 Oregon...

  5. 78 FR 24197 - Product Cancellation Order for Certain Pesticide Registrations

    Science.gov (United States)

    2013-04-24

    ... Brand 2-Benzyl-4- Disinfectant. chlorophenol; o- phenylphenol. 001043-00115 Process Vesphene II 4-Tert amylphenol; o- ST. phenylphenol. 001448-00092 Busan 1024 3,5,7-Triaza-1- azoniatricyclo(3.3. 1.1...

  6. family characteristics of nigerian women with severe mental illness ...

    African Journals Online (AJOL)

    2011-06-06

    Jun 6, 2011 ... Many reported well functioning extended family with 55% having regular .... the married women had four or fewer number .... to the high fertility of 5.7 (meaning that the average .... distress in carers of people with mental.

  7. Influence of processing methods on mycoflora changes during ...

    African Journals Online (AJOL)

    SAM

    2014-05-07

    May 7, 2014 ... dried plantain chips were scrapped and were aseptically plated on potato dextrose agar (PDA) plate and incubated at room tempera- ture for 5-7 days as ..... mycoflora changes during storage of plantain chips and the health.

  8. Obstetric and neonatal outcome in pregnancies complicated by hemolysis elevated liver enzymes low platelet count syndrome at a tertiary care centre in India

    Directory of Open Access Journals (Sweden)

    Nidhi O. Bang

    2016-07-01

    Conclusions: A multidisciplinary approach is of utmost importance along with early diagnosis and prompt treatment to prevent the cataclysmic deterioration of patients with HELLP syndrome. [Int J Reprod Contracept Obstet Gynecol 2016; 5(7.000: 2407-2412

  9. A new chromone from Hymenocallis littoralis Salisb. (Amaryllidaceae).

    Science.gov (United States)

    Anh, Dinh Thi Phuong; Duong, Tran Bach; Hoang, Vu Dinh

    2014-01-01

    A new chromone, 5,7-dihydroxy-6,8-dimethoxy-2-methyl-4H-chromen-4-one (1), together with seven known compounds, 5,7-dihydroxy-6-methoxy-2-methyl-4H-chromen-4-one (pisonin B) (2), 5,7-dihydroxy-2-methyl-4H-chromen-4-one (noreugenin) (3), 5-hydroxy-7-methoxy-2-methyl-4H-chromen-4-one (eugenin) (4), (2S)-7,4'-dihydroxyflavan (5), 3',7-dihydroxy-4'-methoxy-8-methylflavan (6), 3',7-dihydroxy-4'-methoxyflavan (7) and 6,8-dimethyl-5,7,4'-trihydroxyflavanone (( - )-farrerol) (8), were isolated from Hymenocallis littoralis Salisb. (Amaryllidaceae) growing in Vietnam. Their structures were determined based on spectroscopic and physicochemical analyses.

  10. Experiment list: ERX096851 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 1,5.7,46108 Epigenetic comparison of human DNA in specific human tissues to human...ERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS. 31821072,96.

  11. Phytophthora capsici - Loss of Heterozygosity (LOH): A Widespread Mechanism for Rapid Adaptation ( 7th Annual SFAF Meeting, 2012)

    Energy Technology Data Exchange (ETDEWEB)

    Mudge, Joanne [NCGR

    2012-06-01

    Joanne Mudge on "Phytophthora capsici - Loss of Heterozygosity (LOH): A Widespread Mechanism for Rapid Mutation" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  12. A new benzofuranolignan and a new flavonol derivative from the stem of Morus australis

    Institute of Scientific and Technical Information of China (English)

    Qing Jian Zhang; Di Zao Li; Ruo Yun Chen; De Quan Yu

    2008-01-01

    A new benzofuranolignan austrafuran A(1)and a new flavonol derivative 5,7,2',4'-tetrahydroxy-3-methoxyflavone(2)were isolated from the stem of Morus australis.Their structures were determined on the basis of spectroscopic evidences.

  13. Maternal and fetal outcome in subclinical hypothyroidism in Jammu region, North India

    Directory of Open Access Journals (Sweden)

    Gagan Singh

    2016-07-01

    Conclusions: In view of adverse maternal and fetal outcome, detecting and treating the women with subclinical hypothyroidism in early pregnancy will improve the perinatal outcome. [Int J Reprod Contracept Obstet Gynecol 2016; 5(7.000: 2362-2366

  14. Open Educational Resources in Learning Networks

    NARCIS (Netherlands)

    Sloep, Peter

    2009-01-01

    Sloep, P. B. (2009). Open Educational Resources in Learning Networks. Keynote presentation at the 23rd ICDE World Conference on Open Learning and Distance Education 2009. June, 5-7, 2009, Maastricht, The Netherlands.

  15. Association of recurrent pregnancy loss with chromosomal ...

    African Journals Online (AJOL)

    EB

    Results: Parental chromosomal abnormality was detected in 28 cases (2.8% of all cases, 5.7% of the couples) most of which ... Key words: chromosomal abnormality, recurrent pregnancy loss, thrombophilia ..... significant role in infertility.

  16. Finantsjuhtimine raamatukogus. I / Kate-Riin Kont

    Index Scriptorium Estoniae

    Kont, Kate-Riin, 1971-

    2008-01-01

    Järg. nr. 2 lk. 5-7, nr. 3 lk. 5-8. Raamatukogu ressursside paigutamise ja finantsjuhtimise teoreetilised lähtekohad avaliku sektori organisatsioonide kontekstis, finants- ja tulemusjuhtimise suundumused avaliku halduse organisatsioonides

  17. [Results of Habitat Evaluation Procedures at Rocky Mountain Arsenal NWR : Spatial and Tabular Data

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains a basic map depicting the average of 5-7 transects/sections and 5 species, as well as a table detailing the preliminary results of habitat...

  18. Community Perception of Maternal Mortality in Northeastern Nigeria

    African Journals Online (AJOL)

    Erah

    have misconceptions about the causes of maternal mortality. There were many ... 2015 as part of the Millennium. Development Goals (goal number 5). 7 . To .... said there was no maternal death happen .... assisted states in Nigeria 2004.

  19. Synthese van nieuwe sterolen en provitamines D met gewijzigde zijketen

    NARCIS (Netherlands)

    de Vries, Harmen

    1951-01-01

    All sterols which obtain antirachitic activity by ultraviolet irradiation show a conjugated system of double bonds (5,7) in ring B and a hydroxyl group at C3 in the cyclopentanoperhydrophenanthrene skeleton. ... Zie: Summary.

  20. Sediment yield assessment in the Upper Wadi Kebir catchment ...

    African Journals Online (AJOL)

    important loss of annual water storage rate that is ranging between 2 and 5% [7, 8]. ..... events are so important to have high impact energy that destroys surface aggregates ... the intermittent streams dry without any runoff to cause soil erosion.