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Sample records for letting students choose

  1. Typing Compared with Handwriting for Essay Examinations at University: Letting the Students Choose

    Science.gov (United States)

    Mogey, Nora; Paterson, Jessie; Burk, John; Purcell, Michael

    2010-01-01

    Students at the University of Edinburgh do almost all their work on computers, but at the end of the semester they are examined by handwritten essays. Intuitively it would be appealing to allow students the choice of handwriting or typing, but this raises a concern that perhaps this might not be "fair"--that the choice a student makes,…

  2. WHY WOULD YOUNG STUDENTS CHOOSE ENTREPRENEURSHIP?

    Directory of Open Access Journals (Sweden)

    Muntean Andreea

    2012-12-01

    Full Text Available The entrepreneurship is widely considered as a solution for economic problems. The number of young people who start a new business is in increasing. The students’ motivation for choosing entrepreneurship is the research purpose of this paper. A survey developed in Alba Iulia, on a number of 100 students’ points out the relevant motivation why young people choose entrepreneurial alternative. The results showed that most of the actual students would choose to be entrepreneurs because they want to improve their life standards, to explore new business opportunities and to have a social status. In conclusion, the teachers, the governmental authorities and all the others interested in stimulating the entrepreneurial motivation should their words and actions affect potential entrepreneurs’ perceptions of entrepreneurial feasibility and net desirability.

  3. The Identity of Students Choosing Marketing Programs

    Directory of Open Access Journals (Sweden)

    Barreto, Idaly

    2009-12-01

    Full Text Available The purpose of this study is to look deeply into the identity of young students interested in training professional in marketing programs in Bogotá, Colombia. This descriptive study was conducted with the application of multidimensional surveys to 262 young people from five universities that offer training in marketing. The results show that there are differences and similarities in the lifestyles of young people who choose to study Marketing. The first, relating mainly to the identities assumed by students of daytime and nighttime that differ in their activities and more income. The second, by the increasing use and development of academic and social activities through the Internet of interest to young people today. It is hoped that these results provide the administrative and academic management of marketing programs that result in better communication and care of students as consumers.

  4. Hypnotic relaxation vs amitriptyline for tension-type headache: let the patient choose.

    Science.gov (United States)

    Ezra, Yacov; Gotkine, Marc; Goldman, Sylvie; Adahan, Haim Moshe; Ben-Hur, Tamir

    2012-05-01

    Although both pharmacological and behavioral interventions may relieve tension-type headache, data are lacking regarding treatment preference, long-term patient compliance, and feasibility of behavioral intervention in a standard neurological outpatient clinic setting. To describe patient choice, long-term compliance, and clinical outcome in a neurological clinic setting where patients are given the choice of the approach they wish to pursue. Patients presenting to the headache clinic with a diagnosis of tension-type headache that justified prophylactic therapy (frequent episodic tension-type headache or chronic tension-type headache) were given the choice of amitriptyline (AMT) treatment or hypnotic relaxation (HR), and were treated accordingly. Patients were given the option to cross-over to the other treatment group at each visit. HR was performed during standard length neurology clinic appointments by a neurologist trained to perform hypnosis (Y.E.). Follow-up interviews were performed between 6 and 12 months following treatment initiation to evaluate patient compliance, changes in headache frequency or severity, and quality-of-life parameters. Ninety-eight patients were enrolled, 92 agreed to receive prophylactic therapy of some kind. Fifty-three (57.6%) patients chose HR of which 36 (67.9%) actually initiated this treatment, while 39 (42.4%) chose pharmacological therapy with AMT of which 25 (64.1%) patients actually initiated therapy. Patients with greater analgesic use were more likely to opt for AMT (P= .0002). Eleven of the patients initially choosing AMT and 2 of the patients initially choosing HR crossed over to the other group. Seventy-four percent of the patients in the HR group and 58% of patients in the AMT group had a 50% reduction in the frequency of headaches (P= .16). Long-term adherence to treatment with HR exceeded that of AMT. At the end of the study period, 26 of 47 patients who tried HR compared with 10 of 27 who tried AMT continued

  5. Letting Your Students "Fly" in the Classroom.

    Science.gov (United States)

    Adams, Thomas

    1997-01-01

    Students investigate the concept of motion by making simple paper airplanes and flying them in the classroom. Students are introduced to conversion factors to calculate various speeds. Additional activities include rounding decimal numbers, estimating, finding averages, making bar graphs, and solving problems. Offers ideas for extension such as…

  6. Choosing a Wiki Platform for Student Projects--Lessons Learned

    Science.gov (United States)

    Malaga, Ross A.

    2010-01-01

    Wikis offer many benefits, such as two-way flows of information, early and consistent feedback, and greater student group collaboration, in an educational setting. Some researchers have already reported on the use of Wikis in their classes. However, instructors must choose an appropriate Wiki platform in order to receive all of the benefits of…

  7. Why do students choose English as a medium of instruction?

    DEFF Research Database (Denmark)

    Lueg, Klarissa; Lueg, Rainer

    2015-01-01

    increases the employability of graduates, they do not sufficiently consider that study strategies differ substantially across social milieus and between the sexes. Failing to account for social distance to the educational system in choosing EMI can foster social inequality, and contribute...... by the Bourdieusian perspective, this relationship is not directly observable but rather operates through hidden mechanisms, such as cultural capital (relative English proficiency) and a better sense of gaming and positioning (career orientation). Business students from the lowest stratum self-select against EMI due...

  8. Choosing child and adolescent psychiatry: factors influencing medical students.

    Science.gov (United States)

    Volpe, Tiziana; Boydell, Katherine M; Pignatiello, Antonio

    2013-11-01

    To examine the factors influencing medical students to choose child and adolescent psychiatry as a career specialty. Quantitative and qualitative methods were used. A web-based survey was distributed to child and adolescent psychiatrists at the University of Toronto. In-depth interviews were held with select child and adolescent psychiatrists as well as a focus group with psychiatry residents. Retrospective accounts of the factors that influenced their decision to choose psychiatry and/or child and adolescent psychiatry as a specialty were collected. Ninety-two percent of participants indicated that recruitment of child psychiatrists in Canada is a problem. The recent decision by the Royal College of Physicians and Surgeons to recognize child and adolescent psychiatry as a subspecialty and introduce an extra year of training was identified as a further challenge to recruitment efforts. Other deterrents included lower salary than other subspecialties, lack of exposure during training, stigma, and lack of interest in treating children. Recruitment into psychiatry was enhanced by good role modeling, early exposure in medical school, an interest in brain research, and career and lifestyle issues. A rebranding of the role and perception of psychiatry is needed to attract future psychiatrists. Early exposure to innovations in child and adolescent psychiatry and positive role models are critical in attracting medical students. Recruitment should begin in the first year of medical school and include an enriched paediatric curriculum.

  9. Choosing Child and Adolescent Psychiatry: Factors Influencing Medical Students

    Science.gov (United States)

    Volpe, Tiziana; Boydell, Katherine M.; Pignatiello, Antonio

    2013-01-01

    Objective: To examine the factors influencing medical students to choose child and adolescent psychiatry as a career specialty. Method: Quantitative and qualitative methods were used. A web-based survey was distributed to child and adolescent psychiatrists at the University of Toronto. In-depth interviews were held with select child and adolescent psychiatrists as well as a focus group with psychiatry residents. Retrospective accounts of the factors that influenced their decision to choose psychiatry and/or child and adolescent psychiatry as a specialty were collected. Results: Ninety-two percent of participants indicated that recruitment of child psychiatrists in Canada is a problem. The recent decision by the Royal College of Physicians and Surgeons to recognize child and adolescent psychiatry as a subspecialty and introduce an extra year of training was identified as a further challenge to recruitment efforts. Other deterrents included lower salary than other subspecialties, lack of exposure during training, stigma, and lack of interest in treating children. Recruitment into psychiatry was enhanced by good role modeling, early exposure in medical school, an interest in brain research, and career and lifestyle issues. Conclusions: A rebranding of the role and perception of psychiatry is needed to attract future psychiatrists. Early exposure to innovations in child and adolescent psychiatry and positive role models are critical in attracting medical students. Recruitment should begin in the first year of medical school and include an enriched paediatric curriculum. PMID:24223044

  10. Choose Privacy Week: Educate Your Students (and Yourself) about Privacy

    Science.gov (United States)

    Adams, Helen R.

    2016-01-01

    The purpose of "Choose Privacy Week" is to encourage a national conversation to raise awareness of the growing threats to personal privacy online and in day-to-day life. The 2016 Choose Privacy Week theme is "respecting individuals' privacy," with an emphasis on minors' privacy. A plethora of issues relating to minors' privacy…

  11. Factors influencing Zimbabwean physiotherapy students in choosing physiotherapy as a career

    OpenAIRE

    T. Mkondo; W. Mudzi; N. P. Mbambo

    2007-01-01

    People join professions for different reasons and the same applies to physiotherapists. The aim of the study was to identify the reasons for choosing physiotherapy as a career by Zimbabwean physiotherapy students. The study used a descriptive cross-sectional design where a questionnaire was administered to 60 students. Data were collected on the demographics of the students and also on their rating on the importance of 12 factors for their influence in them choosing physiotherapy as a career....

  12. Choosing Teaching Profession as a Career: Students' Reasons

    Science.gov (United States)

    Balyer, Aydin; Özcan, Kenan

    2014-01-01

    The success of educational change inevitably depends on the quality and performance of teachers. Therefore, the importance of employing high quality teachers is crucial for educational systems. Choosing talented and committed brains to teaching career depends on making it an attractive profession. It is considered that there are some reasons why…

  13. Let's Talk! ESL Students' Needs and Writing Centre Philosophy

    Science.gov (United States)

    Moussu, Lucie

    2013-01-01

    When university/college faculty members believe that ESL students' writing skills are not equivalent to those of native speakers, they frequently send these ESL students to their institution's writing centres (WCs). However, this often results in frustration for WC staff, the students, and faculty members. This article first describes ESL…

  14. Are nursing students safe when choosing gluteal intramuscular injection locations?

    Science.gov (United States)

    Cornwall, J

    2011-01-01

    Nurses are required to perform gluteal intramuscular (IM) injections in practice. There are dangers associated with erroneous performance of this task, particularly with dorsogluteal injections. Knowledge regarding safe injection practice is therefore vital for nursing students. Fifty-eight second year students at a New Zealand Nursing School were given schematic drawings of the posterior and lateral aspects of the gluteal region. They were asked to mark and justify the safest location for gluteal IM injections. Fifty-seven students marked the dorsal schematic and one the lateral, with 38 (66.7%) marking in the upper outer quadrant (UOQ). Twenty indicating the UOQ (52.6%) wrote 'sciatic' or 'nerve' in justifying their location. Nineteen (33.3%) marked a location outside the UOQ; nine (47.4%) of these mentioned 'sciatic' or 'nerve' as reasons for injection safety. Overall, 50% of students mentioned 'sciatic' or 'nerve' in justifying the safety of their chosen injection location. Results suggest some second year nursing students do not understand safe gluteal IM injection locations and rationale. Current teaching practices and IM injection techniques could be revisited to prepare students more effectively; this may help prevent pathologies arising from this procedure.

  15. Human anatomy: let the students tell us how to teach.

    Science.gov (United States)

    Davis, Christopher R; Bates, Anthony S; Ellis, Harold; Roberts, Alice M

    2014-01-01

    Anatomy teaching methods have evolved as the medical undergraduate curriculum has modernized. Traditional teaching methods of dissection, prosection, tutorials and lectures are now supplemented by anatomical models and e-learning. Despite these changes, the preferences of medical students and anatomy faculty towards both traditional and contemporary teaching methods and tools are largely unknown. This study quantified medical student and anatomy faculty opinion on various aspects of anatomical teaching at the Department of Anatomy, University of Bristol, UK. A questionnaire was used to explore the perceived effectiveness of different anatomical teaching methods and tools among anatomy faculty (AF) and medical students in year one (Y1) and year two (Y2). A total of 370 preclinical medical students entered the study (76% response rate). Responses were quantified and intergroup comparisons were made. All students and AF were strongly in favor of access to cadaveric specimens and supported traditional methods of small-group teaching with medically qualified demonstrators. Other teaching methods, including e-learning, anatomical models and surgical videos, were considered useful educational tools. In several areas there was disharmony between the opinions of AF and medical students. This study emphasizes the importance of collecting student preferences to optimize teaching methods used in the undergraduate anatomy curriculum. © 2013 American Association of Anatomists.

  16. Student reflections on choosing to study science post-16

    Science.gov (United States)

    Pike, Angela G.; Dunne, Máiréad

    2011-06-01

    The research recounted in this paper was designed primarily to attempt to understand the reasons for the low uptake of the natural sciences beyond compulsory education in England. This has caused widespread concern within governmental quarters, university science departments and the scientific community as a whole. This research explored the problem from the position of the students who recently made their choices. The student voices were heard through a series of interviews which highlighted the complexities of the process of post-16 choice. Social theories of pedagogy and identity, such as those of Basil Bernstein, were used in an analysis of the interview texts. Dominant themes used by the students in rationalising their post-16 subject choice related to their past pedagogical experiences, school discourses of differentiation and the students' notions of their future educational and occupational pathways. This study provides no simple solutions but highlights the importance of student voice to our understandings of what influences subject choice at this critical post-16 stage.

  17. [Dentistry students' reasons for choosing dentistry as a career in Damascus University].

    Science.gov (United States)

    Mashlah, A M

    2012-05-01

    This cross-sectional questionnaire survey assessed the motives for choosing dentist as a profession among dentistry students at Damascus University, Syrian Arab Republic. A total of 408 undergraduate students (233 males and 175 females) aged 18-23 years were selected randomly from students in the second, third and fourth years of dentistry study. They completed a questionnaire that enquired about their reasons for studying dentistry as well as their sociodemographic characteristics. The number of admissions in females had increased over the 3 years. Most parents of the students were university-educated. The main motivation for choosing dentistry was as a means to achieve personal goals, including getting a good job abroad, having financial independence, and attaining a good reputation. There were significant differences between the sexes with regard to the reasons for choosing dentistry.

  18. The Effect of Choosing versus Receiving Feedback on College Students' Performance

    Science.gov (United States)

    Cutumisu, Maria; Schwartz, Daniel L.

    2016-01-01

    This study examines the effect of choosing versus receiving feedback on the learning performance of n = 98 post-secondary students from California on a digital poster design task. The study employs a yoked experimental design where college students are randomly assigned to play a choice-based assessment game, Posterlet, in one of two conditions,…

  19. Influential Factors in Choosing Higher Education Institutions Among Students

    Directory of Open Access Journals (Sweden)

    Zlata Kastelic

    2017-05-01

    Full Text Available Purpose and Originality:The purpose of this article is to determine which factors are influential for students inchoosinga specific higher education institution. Method:By analyzing available literature and existing surveys, we gained in-depthknowledgeof key theoretical conceptsof the researched problem. The latter represents the basis on which we have designed our own research algorithm and conducted a proper survey. The purpose of the research was to analyze, which factors affect the most individuals to enroll in aspecific higher education institution, and to what extent our findings coincide with other studies’ findings. Results:The results showed a significant degree of correlation between factors that motivate foreign students to enrol in a higher education institution. Society:By knowing which areinfluential factors for students’ enrollment in HEIs the latterwill be able to recognize and satisfy needs and desires of potential students and subsequently design attractive studying programmes and thus equip them with knowledge in order to become competent individuals to successfully compete on labour market. Limitations/Future Research: Generalisation of results was limited due to the small size of the sample, and since all respondents came from only one Slovenian region. But since this is the first such surveyit represents a complex and remarkable preliminary study that can be upgradedand generate important contribution in understanding the key factors, which stimultae students for enrollment in higher education institutions.

  20. A study among dental students regarding the factors influenced dental students to choose dentistry as career

    Science.gov (United States)

    AnbuSelvan, Gobichetti Palayam Jagatheeswaran; Gokulnathan, Subramaniam; PrabuRajan, Vilvanathan; RajaRaman, Gangadharan; Kumar, Singaravelu Suresh; Thagavelu, Arthie

    2013-01-01

    Introduction: Career choice is a complex decision for students since it determines the kind of profession that they intend to pursue in life. As students try to make a career choice while in secondary school, they face the problem of matching their career choices with their abilities and school performance. Aims: The purpose of this study was to examine factors influencing career choice among dental college students in private dental collages in Tamil Nadu, India. Settings and Design: The study was conducted using descriptive survey design with a population of 989 students. The data for this study was collected using a questionnaire and interview schedules. Materials and Methods: The data for this study was collected using questionnaire previously used by Swati Shah and Rajaraman and interview schedules. The analysis of the study was based on the factors: Outcome expectations, gender, personal interests, and other factors. Results and Conclusion: The most common reason for among the dental students to choose dental science as their career choice was self-interested followed by didn′t get medicine degree, prestige and gives respect. The least common reasons observed in the study population were inspired by dentists. The findings of this study indicate that availability the most influential factors affecting career choices among students. PMID:23946573

  1. Human Anatomy: Let the Students Tell Us How to Teach

    Science.gov (United States)

    Davis, Christopher R.; Bates, Anthony S.; Ellis, Harold; Roberts, Alice M.

    2014-01-01

    Anatomy teaching methods have evolved as the medical undergraduate curriculum has modernized. Traditional teaching methods of dissection, prosection, tutorials and lectures are now supplemented by anatomical models and e-learning. Despite these changes, the preferences of medical students and anatomy faculty towards both traditional and…

  2. Let's collocate: student generated worksheets as a motivational tool

    OpenAIRE

    Simpson, Adam John

    2006-01-01

    This article discusses the process of producing collocation worksheets and the values of these worksheets as a motivational tool within a tertiary level preparatory English program. Firstly, the method by which these worksheets were produced is described, followed by an analysis of their effectiveness as a resource in terms of student motivation, personalisation, involvement in the development of the curriculum and in raising awareness of corpus linguistics and its applications.

  3. Web site lets solar scientists inform and inspire students

    Science.gov (United States)

    Hauck, Karin

    2012-07-01

    Where on the Web can a middle school girl ask a female solar scientist about solar storms, the course and behavior of charged solar particles, and the origin of the Sun's dynamo—and also find out what the scientist was like as a child, whether the scientist has tattoos or enjoys snowboarding, what she likes and dislikes about her career, and how she balances her energy for work and family life? These kinds of exchanges happen at Solar Week (http://www.solarweek.org; see Figure 1). Established in 2000, Solar Week is an online resource for middle and lower high school students about the science of the Sun, sponsored by the Center for Science Education at the Space Sciences Laboratory (CSE@SSL) at the University of California, Berkeley (UC Berkeley). The Web site's goals are to educate students about the Sun and solar physics and to encourage future careers in science—especially for girls. One way is by giving solar scientists the chance to be relatable role models, to answer students' questions, and to share their experiences in an online forum.

  4. Student nurses' motivation to choose gerontological nursing as a career in China: a survey study.

    Science.gov (United States)

    Cheng, Min; Cheng, Cheng; Tian, Yan; Fan, Xiuzhen

    2015-07-01

    The world's population is aging, and the need for nurses is increasing. Working with older adults, however, has always been an unpopular career choice among student nurses. It is important to understand student nurses' motivation for choosing gerontological nursing as a career. The purpose of this study was to examine the motivation for choosing gerontological nursing as a career and to identify the associated factors among student nurses. Cross-sectional survey. Participants were last-semester student nurses from 7 universities offering nursing undergraduate programs in Shandong, China. Of the 1290 student nurses, 916 completed the survey (a response rate of 71.0%). The outcome variable was the motivation to choose gerontological nursing as a career. This was measured using a motivation questionnaire that included expectancy and value subscales. Other instruments included the Chinese version of the Facts on Aging Quiz I, the Geriatrics Attitudes Scale, the Anxiety about Aging Scale, a clinical practice environment questionnaire and a self-administered general information questionnaire. Student nurses' expectancy and value aspects of motivation for choosing gerontological nursing as a career were both at a moderate level; the highest value they held was of personal interest. Clinical practice environment, anxiety about aging and the attitudes about geriatrics were the main factors influencing student nurses' motivation to choose gerontological nursing as a career in China. It is imperative for nurse educators to improve the gerontological nursing clinical practice environment for student nurses. Moreover, cultivating student nurses' positive attitudes about geriatrics and relieving anxiety about aging could be beneficial. Copyright © 2015. Published by Elsevier Ltd.

  5. First-year dental students' motivation and attitudes for choosing the dental profession.

    Science.gov (United States)

    Avramova, Nadya; Yaneva, Krassimira; Bonev, Boyko

    2014-01-01

    To determine first-year dental students' current motivation and attitudes for choosing the dental profession at the Faculty of Dental Medicine, Medical University - Sofia, Bulgaria. An anonymous questionnaire, consisting of 12 questions about students' socio-demographic profile and their motivation for choosing dentistry, was administered to 119 first-year dental students at the Faculty of Dental Medicine of the Medical University of Sofia. The study was conducted at the beginning of the 2012-2013 academic year. The data was processed and analyzed with the following software: Microsoft Windows Server 2008 R2; Microsoft SQL Server 2008; Internet Information Server 7.5.; Microsoft SharePoint Server 2010. The majority of the students (73%) were self-motivated for choosing dentistry as a career; 61% of them did not have relatives in the medical profession; 43% chose dental medicine because it is a prestigious, humane and noble profession; 50% - for financial security; 59% - because of the independence that it provides. There were no significant differences in the motivation between males and females. Independence, financial security and 'prestige' were the predominant motivating factors in this group of first-year dental students. Determining the reasons for choosing dentistry has important implications for the selection and training of students as well as for their future job satisfaction. Copyright © 2014 by Academy of Sciences and Arts of Bosnia and Herzegovina.

  6. Encouraging French medical students to choose a career in psychiatry: how and why?

    Science.gov (United States)

    Andlauer, Olivier; Van Effenterre, Aude; Haffen, Emmanuel; Sechter, Daniel; Farooq, Kitty; Lydall, Gregory; Malik, Amit; Bhugra, Dinesh

    2013-08-01

    There is an increasing demand for psychiatrists in France. This paper reviews the reasons for French medical students choosing psychiatry and the rationale and mechanisms for encouraging them towards this medical speciality. The main factors associated with choosing psychiatry as a career are the quantity and quality of undergraduate training and placements in psychiatry, better attitudes towards psychiatry and more emphasis on a positive life/work balance. The quality of postgraduate training can also influence students' decisions. Medical students should be encouraged to choose psychiatry first to counterbalance the existing stigma towards mental illness within the society, but also towards psychiatry within the medical profession, and second because of the current decline in French medical demography. Ways to improve recruitment are a selection process that favours a large number of psychiatric trainees, and an increase in the quality and quantity of training. Providing medical students with relevant information about training in psychiatry, notably through a national trainees' association, will not only improve the quality of care by increasing recruitment in psychiatry, but also ensure that all future doctors are familiar with and develop positive attitudes towards mental health issues.

  7. Influencing Factors on Choosing Psychiatry as a Career: An Exploration in Chinese University Students.

    Science.gov (United States)

    Zhong, Jiawei; Zheng, Luna; Chen, Xiaoling; Gao, Qianqian; Zhang, Bingren; Wang, Wei

    2016-12-01

    There is a consistent need of psychiatric professionals in the world including China, and a consistent challenge to recruit more medical students into the psychiatric careers. We aimed to look for factors which have an impact on career-choosing of psychiatry in Chinese university students. We invited 508 non-medical students (NM), 304 medical students without (MO) and 123 medical students with clinical internship experience (MW), to answer a matrix of 43 questions regarding factors influencing career-choosing of psychiatry. Answers to these questions were analyzed through exploratory and confirmatory factor analyses, once the latent factors were identified and structurally-validated, their mean scores in three groups of students were calculated. Five factors with five items each were identified, namely social status inferiority, career importance, practice reward, career preference, and practice stress. NM scored lower than MO and MW did on Social Status Inferiority; NM group scored higher than MO and MW groups did on Career Importance; MW scored lower than NM and MO did on Practice Reward and on Career Preference; Regarding Practice Stress, NM scored higher than MO did, who then in turn, scored higher than MW did. In addition, Practice Stress was positively correlated with advice of the medical educators; and Social Status Inferiority and Career Preference were positively correlated with the psychiatry teaching of the medical educators. Raising career rewards, improving social status, and reinforcing psychiatric education might help to recruit more medical students to specialize in psychiatry practicing.

  8. Choosing not to choose.

    Science.gov (United States)

    Sunstein, Cass R

    2014-10-01

    Choice can be an extraordinary benefit or an immense burden. In some contexts, people choose not to choose, or would do so if they were asked. In part because of limitations of "bandwidth," and in part because of awareness of their own lack of information and potential biases, people sometimes want other people to choose for them. For example, many people prefer not to make choices about their health or retirement plans; they want to delegate those choices to a private or public institution that they trust (and may well be willing to pay a considerable amount to those who are willing to accept such delegations). This point suggests that however well accepted, the line between active choosing and paternalism is often illusory. When private or public institutions override people's desire not to choose and insist on active choosing, they may well be behaving paternalistically, through a form of choice-requiring paternalism. Active choosing can be seen as a form of libertarian paternalism, and a frequently attractive one, if people are permitted to opt out of choosing in favor of a default (and in that sense permitted not to choose); it is a form of nonlibertarian paternalism insofar as people are required to choose. For both ordinary people and private or public institutions, the ultimate judgment in favor of active choosing, or in favor of choosing not to choose, depends largely on the costs of decisions and the costs of errors.

  9. Thai students and their reasons for choosing to study in United Kingdom universities

    OpenAIRE

    Tarry, Estelle F

    2008-01-01

    This thesis seeks to consider Thai students and their reasons for choosing to study in United Kingdom universities. Through the literature review it has been identified that higher education is globally expanding. Competing knowledgebased economies with higher education institutions have led education to be considered a market commodity and consequently the marketization of higher education in competitive world markets. This is exemplified by discussion of the United Kingdom higher education ...

  10. Choosing Wisely Canada Students and Trainees Advocating for Resource Stewardship (STARS) campaign: a descriptive evaluation.

    Science.gov (United States)

    Cardone, Franco; Cheung, Daphne; Han, Angela; Born, Karen B; Alexander, Lisa; Levinson, Wendy; Wong, Brian M

    2017-12-19

    Resource stewardship is being increasingly recognized as an essential competency for physicians, but medical schools are just beginning to integrate this into education. We describe the evaluation of Choosing Wisely Canada's Students and Trainees Advocating for Resource Stewardship (STARS) campaign, a student-led campaign to advance resource stewardship education in medical schools across Canada. We evaluated the campaign 6 months after its launch, in November 2015. STARS students were administered a telephone survey eliciting a description of the initiatives that they had implemented or planned to implement at their schools to promote resource stewardship, and exploring their perceptions of facilitators of and barriers to successful implementation of their initiatives. We used a mixed-methods approach to analyze and summarize the data. Twenty-seven (82%) of the 33 eligible students representing all 17 medical schools responded. In 14 schools (82%), students led various local activities (e.g., interest groups, campaign weeks) to raise awareness about resource stewardship among medical students and faculty. Students contributed to curriculum change (both planned and implemented) at 10 schools (59%). Thematic analysis revealed key program characteristics that facilitated success (e.g., pan-Canadian student network, local faculty champion) as well as barriers to implementing change (e.g., complex processes to change curriculum, hierarchical nature of medical school). This student-led campaign, with support from local faculty and Choosing Wisely Canada staff, led to awareness-building activities and early curricula change at medical schools across Canada. Future plans will build on the initial momentum created by the STARS campaign to sustain and spread local initiatives. Copyright 2017, Joule Inc. or its licensors.

  11. Why medical students choose psychiatry - a 20 country cross-sectional survey.

    Science.gov (United States)

    Farooq, Kitty; Lydall, Gregory J; Malik, Amit; Ndetei, David M; Bhugra, Dinesh

    2014-01-15

    Recruitment to psychiatry is insufficient to meet projected mental health service needs world-wide. We report on the career plans of final year medical students from 20 countries, investigating factors identified from the literature which influence psychiatric career choice. Cross sectional electronic or paper survey. Subjects were final year medical students at 46 medical schools in participating countries. We assessed students' career intentions, motivations, medical school teaching and exposure to psychiatry. We assessed students' attitudes and personality factors. The main outcome measure was likelihood of specializing in psychiatry. Multilevel logistic regression was used to examine the joint effect of factors upon the main outcome. 2198 of 9135 (24%) of students responded (range 4 to 91%) across the countries. Internationally 4.5% of students definitely considered psychiatry as a career (range 1 to 12%). 19% of students (range 0 to 33%) were "quite likely", and 25% were "definitely not" considering psychiatry. Female gender, experience of mental/physical illness, media portrayal of doctors, and positive attitudes to psychiatry, but not personality factors, were associated with choosing psychiatry. Quality of psychiatric placement (correlation coefficient = 0.22, p school, experience of psychiatric enrichment activities (special studies modules and university psychiatry clubs), experience of acutely unwell patients and perceived clinical responsibility were all associated with choice of psychiatry.Multilevel logistic regression revealed six factors associated with students choosing psychiatry: importance of own vocation, odds ratio (OR) 3.01, 95% CI 1.61 to 5.91, p school, OR 10.8 (5.38 to 21.8, p student selection and psychiatry teaching which affect career choice. Addressing these factors may improve recruitment to psychiatry internationally.

  12. READINESS OF SENIOR STUDENTS FROM THE CARPATHIAN TERRAIN TO CHOOSE TEACHING PROFESSION: PEDAGOGICAL AND PSYCHOLOGICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    Tetyana Blyznyuk

    2015-04-01

    Full Text Available The article presented at the conference is the study of the problems of upbringing and education of senior pupils from the Carpathian mountain area. Namely the author investigates the students’ readiness for choosing the teaching profession and willingness to work at rural mountain schools. Despite the big number of teachers in the labor market of Ukraine, now the system of education meets an acute issue dealing with the selection to the pedagogical specialties talented creative young people who actually choose teaching profession by nature and strong personal will. Today there are very few teachers whose level of commitment to perform professional duties in Ukrainian education is really high, and this is especially true about mountain school teachers. This phenomenon can be partially explained by the fact that teaching profession has low prestige in our society for the recent decades (Ukrainian teachers are not well-paid, their working conditions in rural Carpathian schools leave much to be desired. Therefore the problem of readiness of high school students to perform professional-pedagogical duties is of particular relevance. The author analyzes the psychological and pedagogical basis of the presented problem, defines the essence and structure of the notion “readiness for choosing the teaching profession”. In the context of solving this issue one of the important conditions the author considers the comprehensive development of senior school students, particularly the development of their creative abilities.

  13. Why medical students choose psychiatry - a 20 country cross-sectional survey

    Science.gov (United States)

    2014-01-01

    Background Recruitment to psychiatry is insufficient to meet projected mental health service needs world-wide. We report on the career plans of final year medical students from 20 countries, investigating factors identified from the literature which influence psychiatric career choice. Methods Cross sectional electronic or paper survey. Subjects were final year medical students at 46 medical schools in participating countries. We assessed students’ career intentions, motivations, medical school teaching and exposure to psychiatry. We assessed students’ attitudes and personality factors. The main outcome measure was likelihood of specializing in psychiatry. Multilevel logistic regression was used to examine the joint effect of factors upon the main outcome. Results 2198 of 9135 (24%) of students responded (range 4 to 91%) across the countries. Internationally 4.5% of students definitely considered psychiatry as a career (range 1 to 12%). 19% of students (range 0 to 33%) were “quite likely”, and 25% were “definitely not” considering psychiatry. Female gender, experience of mental/physical illness, media portrayal of doctors, and positive attitudes to psychiatry, but not personality factors, were associated with choosing psychiatry. Quality of psychiatric placement (correlation coefficient = 0.22, p psychiatry clubs), experience of acutely unwell patients and perceived clinical responsibility were all associated with choice of psychiatry. Multilevel logistic regression revealed six factors associated with students choosing psychiatry: importance of own vocation, odds ratio (OR) 3.01, 95% CI 1.61 to 5.91, p psychiatry before medical school, OR 10.8 (5.38 to 21.8, p psychiatry special study module, OR 1.45 (1.05 to 2.01, p = 0.03) or elective OR 4.28 (2.87- 6.38, p psychiatry club, OR 3.25 (2.87 to 6.38, p psychiatry teaching which affect career choice. Addressing these factors may improve recruitment to psychiatry internationally. PMID

  14. Why medical students do not choose a career in geriatrics: a systematic review.

    Science.gov (United States)

    Meiboom, Ariadne A; de Vries, Henk; Hertogh, Cees M P M; Scheele, Fedde

    2015-06-05

    While the demand for doctors specialised in the medical care of elderly patients is increasing, the interest among medical students for a career in geriatrics is lagging behind. To get an overview of the different factors reported in the literature that affect the (low) interest among medical students for a career in geriatrics, a systematic literature search was conducted using PubMed, Embase, PsycINFO, and ERIC. Quality assessment criteria were applied. Twenty studies met the criteria and were included in the review. In relation to the nature of the work, the preference of medical students is young patients, and acute somatic diseases that can be cured. The complexity of the geriatric patient deters students from choosing this specialty. Exposure by means of pre-clinical and particularly clinical education increases interest. The lack of status and the financial aspects have a negative influence on interest. Exposure to geriatrics by means of education is necessary. The challenge in geriatric education is to show the rewarding aspects of the specialty.

  15. Factors influencing South African optometry students in choosing their career and institution of learning

    Directory of Open Access Journals (Sweden)

    K. P. Mashige

    2011-12-01

    Full Text Available Thechoice of an appropriate career, occupation or profession is one of the most important decisions hat one makes in life and there are many factors which may influence such a decision. The purpose of this study was to establish the factors which influenced students currently studying optometry in South African institutions in deciding on the course of study and choice of institution. Data was collected with a questionnaire on demographics of the students and the factors that might have influenced their choice of optometry as a career and their institution of learning. Data was analysed with descriptive and cross-tabulation statistics. Three hundred and eighty seven students responded to the questionnaire (80.1% response rate. Their ages ranged from 17 to 40 years with a mean of 20.73 ± 2.46 years and included 30.5% males and 69.5% females. They were from the University of Free State 25.1%, University of Johannesburg (29.5%, University of KwaZulu-Natal (29.7% and the University of Limpopo(15.7%. There were 38% Whites, 36.7% Blacks, 22.2% Indians and 3.1% Coloureds. The highest rated factors which influenced their choice of optometry were the desire to help other people (92.8%, job availability after graduation (92%, subjects passed and points obtained in the matric year (91.2% and the potential to earn a good salary (88.6%, respectively. Few rated news and other media (20.9% as an important factor in their decision to choose their current institution of learning while 29.5% reported that failure to gain admission to study other degrees was an important factor. These results may be useful to institutions offering optometry degrees to formulate effective recruitment strategies to attract quality students. Also, they may be useful to career counsellors in counselling prospective students on their career choice and institution of learning. (S Afr Optom 2011 70(1 21-28

  16. An Investigation into Why Students from Regional South Australia Choose to Study Business Programs in the Capital City

    Science.gov (United States)

    Sawyer, Janet; Ellis, Bronwyn

    2011-01-01

    Although Business undergraduate studies are available at the University of South Australia's (UniSA) Centre for Regional Engagement (CRE), both at the Whyalla Campus and the Mount Gambier Regional Centre (MGRC), many students from regional South Australia choose to undertake Business degrees in Adelaide, the state capital, rather than locally.…

  17. DaRT: A CALL System to Help Students Practice and Develop Reasoning Skills in Choosing English Articles.

    Science.gov (United States)

    Yoshii, Rika; Milne, Alastair

    1998-01-01

    Describes DaRT, a computer assisted language-learning system for helping English-as-a-Second-Language students master English articles. DaRT uses a diagrammatic reasoning tool to present communicative contexts for exercises in choosing appropriate articles. This paper describes the development of DaRT and DaRT's system components and concludes…

  18. How High School Students Construct Decision-Making Strategies for Choosing Colleges

    Science.gov (United States)

    Govan, George V.; Patrick, Sondra; Yen, Cherng-Jyn

    2006-01-01

    This study examined how high school seniors construct decision-making strategies for choosing a college to attend. To comprehend their decision-making strategies, we chose to examine this process through the theoretical lens of bounded rationality, which brings to light the complexity in constructing a college choice decision-making strategy…

  19. Impact of Interventions to Increase the Proportion of Medical Students Choosing a Primary Care Career: A Systematic Review.

    Science.gov (United States)

    Pfarrwaller, Eva; Sommer, Johanna; Chung, Christopher; Maisonneuve, Hubert; Nendaz, Mathieu; Junod Perron, Noëlle; Haller, Dagmar M

    2015-09-01

    Increasing the attractiveness of primary care careers is a key step in addressing the growing shortage of primary care physicians. The purpose of this review was to (1) identify interventions aimed at increasing the proportion of undergraduate medical students choosing a primary care specialty, (2) describe the characteristics of these interventions, (3) assess the quality of the studies, and (4) compare the findings to those of a previous literature review within a global context. We searched MEDLINE, EMBASE, ERIC, CINAHL, PsycINFO, The Cochrane Library, and Dissertations & Theses A&I for articles published between 1993 and February 20, 2015. We included quantitative and qualitative studies reporting on primary care specialty choice outcomes of interventions in the undergraduate medical curriculum, without geographic restrictions. Data extracted included study characteristics, intervention details, and relevant outcomes. Studies were assessed for quality and strength of findings using a five-point scale. The review included 72 articles reporting on 66 different interventions. Longitudinal programs were the only intervention consistently associated with an increased proportion of students choosing primary care. Successful interventions were characterized by diverse teaching formats, student selection, and good-quality teaching. Study quality had not improved since recommendations were published in 1995. Many studies used cross-sectional designs and non-validated surveys, did not include control groups, and were not based on a theory or conceptual framework. Our review supports the value of longitudinal, multifaceted, primary care programs to increase the proportion of students choosing primary care specialties. Isolated modules or clerkships did not appear to be effective. Our results are in line with the conclusions from previous reviews and add an international perspective, but the evidence is limited by the overall low methodological quality of the included

  20. Factors influencing students' decision in choosing obstetrics and gynecology as a career in a university hospital in Central Saudi Arabia.

    Science.gov (United States)

    Abu-Rafea, Basim F; Al-Hassan, Basmah F; Al Nakshabandi, Kholoud A; Rahbini, Nora O; Al-Shaikh, Ghadeer K

    2011-07-01

    To determine factors influencing final year medical undergraduate trainees at King Saud University in choosing a career in Obstetrics and Gynecology. In this cross sectional study, the undergraduate final year medical students and interns at King Saud University, Riyadh, Saudi Arabia were asked to complete a survey instrument designed to assess possible attracting and detracting factors. The survey was conducted from January 2010 to February 2010. Factors were analyzed in a univariable and multivariable analysis. The survey was distributed to 507 students. Completed questionnaires were returned by 330 participants (response rate 65%). Overall, 32 (9.7 %) of students listed Obstetrics and Gynecology in their top 3 choices. The rotation of students through Obstetrics and Gynecology was the most influential factor attracting 81.3% of the students who chose to take this course. Faculty interaction was a major reason for attracting students accounting for 71.9%, but resident interaction was less attractive where only 37.5% of students mentioned that they were affected positively by residents. Hands-on experience such as performing deliveries and other procedures were significant attracting factors. (p=0.006 and p=0.004). The findings in this study will hopefully aid in recruiting trainees to the specialty of Obstetrics and Gynecology in Saudi Arabia. Identifying the 5 major attracting factors from our study will allow our institute to integrate these factors in Obstetrics and Gynecology curriculum design, eventually increasing interest in postgraduate training in this specialty.

  1. Why Inquiry? Primary Teachers' Objectives in Choosing Inquiry- and Context-Based Instructional Strategies to Stimulate Students' Science Learning

    Science.gov (United States)

    Walan, Susanne; Nilsson, Pernilla; Ewen, Birgitta Mc

    2017-10-01

    Studies have shown that there is a need for pedagogical content knowledge among science teachers. This study investigates two primary teachers and their objectives in choosing inquiry- and context-based instructional strategies as well as the relation between the choice of instructional strategies and the teachers' knowledge about of students' understanding and intended learning outcomes. Content representations created by the teachers and students' experiences of the enacted teaching served as foundations for the teachers' reflections during interviews. Data from the interviews were analyzed in terms of the intended, enacted, and experienced purposes of the teaching and, finally, as the relation between intended, enacted, and experienced purposes. Students' experiences of the teaching were captured through a questionnaire, which was analyzed inductively, using content analysis. The results show that the teachers' intended teaching objectives were that students would learn about water. During the enacted teaching, it seemed as if the inquiry process was in focus and this was also how many of the students experienced the objectives of the activities. There was a gap between the intended and experienced objectives. Hardly any relation was found between the teachers' choice of instructional strategies and their knowledge about students' understanding, with the exception that the teacher who also added drama wanted to support her students' understanding of the states of water.

  2. You Get to Choose! Motivating Students to Read through Differentiated Instruction

    Science.gov (United States)

    Servilio, Kathryn L.

    2009-01-01

    One way to improve motivation and engagement for students with disabilities in academic areas is to teach at their level and increase their interest in the instruction and activities. Embedding these interests through offering students options within the curriculum can motivate students who were previously having difficulty or not interested in…

  3. Using Consumer Behavior and Decision Models to Aid Students in Choosing a Major.

    Science.gov (United States)

    Kaynama, Shohreh A.; Smith, Louise W.

    1996-01-01

    A study found that using consumer behavior and decision models to guide students to a major can be useful and enjoyable for students. Students consider many of the basic parameters through multi-attribute and decision-analysis models, so time with professors, who were found to be the most influential group, can be used for more individual and…

  4. Some like it hot: medical student views on choosing the emotional level of a simulation.

    Science.gov (United States)

    Lefroy, Janet; Brosnan, Caragh; Creavin, Sam

    2011-04-01

    This study aimed to determine the impact of giving junior medical students control over the level of emotion expressed by a simulated patient (SP) in a teaching session designed to prepare students to handle emotions when interviewing real patients on placements.   Year 1 medical students at Keele University School of Medicine were allowed to set the degree of emotion to be displayed by the SP in their first 'emotional interview'. This innovation was evaluated by mixed methods in two consecutive academic years as part of an action research project, along with other developments in a new communications skills curriculum. Questionnaires were completed after the first and second iterations by students, tutors and SPs. Sixteen students also participated in evaluative focus group discussions at the end of Year 1. Most students found the 'emotion-setting switch' helpful, both when interviewing the SP and when observing. Student-interviewers were helped by the perception that they had control over the difficulty of the task. Student-observers found it helpful to see the different levels of emotion and to think about how they might empathise with patients. By contrast, some students found the 'control switch' unnecessary or even unhelpful. These students felt that challenge was good for them and preferred not to be given the option of reducing it. The emotional level control was a useful innovation for most students and may potentially be used in any first encounter with challenging simulation. We suggest that it addresses innate needs for competence and autonomy. The insights gained enable us to suggest ways of building the element of choice into such sessions. The disadvantages of choice highlighted by some students should be surmountable by tutor 'scaffolding' of the learning for both student-interviewers and student-observers. © Blackwell Publishing Ltd 2011.

  5. Instructor Misbehaviors as Digital Expectancy Violations: What Students Despise and What They Let Slide

    Science.gov (United States)

    MacArthur, Brenda L.; Villagran, Melinda M.

    2015-01-01

    This study examines students' motives for communicating with their instructors when the instructor exhibits inappropriate or unprofessional online behavior. To understand the relationship between what we call instructors' digital expectancy violations and students' motives for communicating with instructors, students' levels of task, social, and…

  6. Choosing the Qualities of Student Leaders: A Matching of Student Voting Preference and Election Results as a Basis for Policy Formulation

    Directory of Open Access Journals (Sweden)

    NOEL M. CAPULONG

    2014-08-01

    Full Text Available – The qualities of student-leaders in the 21st century cannot be underrated. The ability to influence individuals in the context of boundless territories and worldwide integration is of paramount importance to education. Research has revealed that the crux of student leadership in this century is on achieving the right pace and qualities in the changing landscape of borderless society. Choosing the qualities of leaders helps the administrators and students come up with a collaborative policy formulation in the attainment of institutional mission and goals. The research utilized the mixed methods using the qualitative key informant interview, focus group discussions, and researcher’s experience to choose the qualities of student leaders among the students of City College of Calamba. The perceptions of student council leaders from the different schools of Calamba were also surveyed. The student voting preference was matched with the results of Student Council election. The results obtained were recorded and compared to the results of the interview from the experts in the field of educational leadership.

  7. Why medical students choose psychiatry - a 20 country cross-sectional survey

    OpenAIRE

    Farooq, Kitty; Lydall, Gregory J; Malik, Amit; Ndetei, David M; Bhugra, Dinesh

    2014-01-01

    BACKGROUND: Recruitment to psychiatry is insufficient to meet projected mental health service needs world-wide. We report on the career plans of final year medical students from 20 countries, investigating factors identified from the literature which influence psychiatric career choice. METHODS: Cross sectional electronic or paper survey. Subjects were final year medical students at 46 medical schools in participating countries. We assessed students' career intentions, motivations, medical sc...

  8. Why University Students Choose an International Education: A Case Study in Malaysia

    Science.gov (United States)

    Pyvis, David; Chapman, Anne

    2007-01-01

    Why has Australian offshore higher education become the educational investment of choice for many students? What benefits do students anticipate from this education? What is the relationship between educational goals and educational experience? To address these questions, this paper draws on findings from empirical research conducted with students…

  9. Why Do Students Choose Not to Follow All Instructions When Completing Assessment Tasks?

    Science.gov (United States)

    Fleet, Wendy

    2013-01-01

    As academics we often assume that allocating marks to a task will influence student decision-making when it comes to completing that task. Marks are used by lecturers to indicate the relative importance of each of the criteria used for marking the assessment task and we expect the student to respond to the marks' allocation. This Postcard suggests…

  10. Assessing the Reliability of Student Evaluations of Teaching: Choosing the Right Coefficient

    Science.gov (United States)

    Morley, Donald

    2014-01-01

    Many of the studies used to support the claim that student evaluations of teaching are reliable measures of teaching effectiveness have frequently calculated inappropriate reliability coefficients. This paper points to three coefficients that would be appropriate depending on if student evaluations were used for formative or summative purposes.…

  11. Reasons of Choosing Recreation Management Departments within the Body of Tourism Faculties and Expectations of Students

    Directory of Open Access Journals (Sweden)

    Ercan YAVUZ

    2016-12-01

    Full Text Available It is seen that the students graduating from Recreation department work in tourism sectors, but on the other hand, Recreation students can also work in industry and domestic administrations, school recreation, therapeutic recreation etc. This paper presents some solutions by determining that the Recreation administration program’s students’ expectations of future and sufficiency of their education and their happiness

  12. Let's Write It Right! A Student-Oriented Approach for Teaching Letterwriting Skills.

    Science.gov (United States)

    Christensen, Judie

    In the student-oriented approach to writing business letters, students work in small groups to write a series of letters. For the first letter, the groups take the role of consumers, writing letters to order merchandise. The letters are written on overhead transparencies and are then critiqued by the other teams, with an emphasis on constructive…

  13. Enough about You, Let's Talk about Me: Student Voice in the Classroom

    Science.gov (United States)

    Mee, Molly

    2007-01-01

    Many middle school students claim that their voices are ignored in the classroom, where the attitude is too often that the teacher holds the one right answer. Instead of this approach, teachers may wish to use the Socratic Seminar, which prompts students to examine issues and ideas through dialogue and actively involves and motivates them, giving…

  14. Personal competence overview: helping the graduating students to choose a job

    OpenAIRE

    Lauwers, Andre; Bonte, Hilde; Vanmaercke, Rik

    2013-01-01

    Personal Competencies Overview One of the main implications of the Bologna agreement was the switch-over towards competency-based education. Although educations already employed modern education techniques, the competencies were very often not formulated explicitly. Consequently the competencies were not scored individually and the students were not aware what the competencies were. From the education point of view students have to benefit from competency-based education. A key element in ...

  15. Letting Students Take the Lead: A User-Centred Approach to Evaluating Subject Guides

    Directory of Open Access Journals (Sweden)

    Kimberley Hintz

    2010-12-01

    Full Text Available Objective – What do students need and want from library subject guides? Options such as Web 2.0 enhancement are now available to librarians creating subject-specific web pages. Librarians may be eager to implement these new tools, but are such add-ons a priority forstudents? This paper aims to start a dialogue on this issue by presenting the findings of the University of British Columbia (UBC Library’s Subject Guides Working Group (SGWG, which was tasked with assessing current library subject guides in order to make recommendations for the update and future development of UBC Library subject guides.Methods – The working group solicited feedback through a questionnaire that was distributed to undergraduate and graduate students from a variety of disciplines at UBC. The questionnaire included an evaluation of UBC subject guides, as well as guides from other academic libraries that used various platforms such as LibGuides and SubjectsPlus.Results – Respondents to the student questionnaire indicated that a simple and clean layout was of primary importance. Students also desired succinct annotations to resources and limited page scrolling. Meanwhile, few students identified Web 2.0 features such as rating systems and discussion forums as being important for their needs. The working group used the questionnaire data to create a “Top Ten” list of student recommendations.Conclusions – The “Top Ten” list of student recommendations was combined with stakeholder feedback from faculty, liaison librarians and Library Systems and Information Technology representatives to create the SGWG’s final recommendation for subject guide revision and enhancement. For the SGWG these findings called into question the necessity of Web 2.0 technologies within subject guide pages and highlighted the need for further research on the topic of subject guide usability and effectiveness.

  16. Why medical students do not choose a career in geriatrics: a systematic review

    NARCIS (Netherlands)

    Meiboom, A.A.; de Vries, H.; Hertogh, C.M.P.M.; Scheele, F.

    2015-01-01

    Background: While the demand for doctors specialised in the medical care of elderly patients is increasing, the interest among medical students for a career in geriatrics is lagging behind. Methods: To get an overview of the different factors reported in the literature that affect the (low) interest

  17. How choosing science depends on students' individual fit to 'science culture'

    NARCIS (Netherlands)

    Taconis, R.; Kessels, U.

    2009-01-01

    In this paper we propose that the unpopularity of science in many industrialised countries is largely due to the gap between the subculture of science, on the one hand, and students' self-image, on the other. We conducted a study based on the self-to-prototype matching theory, testing whether the

  18. Student Choice in Higher Education: Motivations for Choosing to Study at an International Branch Campus

    Science.gov (United States)

    Wilkins, Stephen; Balakrishnan, Melodena Stephens; Huisman, Jeroen

    2012-01-01

    The international branch campus has emerged as a prominent feature on the international higher education landscape. Although there exists a fairly substantial body of literature that has sought to identify the motivations or choice criteria used by international students to select countries and institutions, there has to date been little research…

  19. How Choosing Science Depends on Students' Individual Fit to "Science Culture"

    Science.gov (United States)

    Taconis, Ruurd; Kessels, Ursula

    2009-01-01

    In this paper we propose that the unpopularity of science in many industrialised countries is largely due to the gap between the subculture of science, on the one hand, and students' self-image, on the other. We conducted a study based on the self-to-prototype matching theory, testing whether the perceived mismatch between the typical…

  20. Choosing Not to Cheat: A Framework to Assess Students' Rationales for Abiding by Academic Integrity Policies

    Science.gov (United States)

    Kolb, Kenneth H.; Longest, Kyle C.; Singer, Alexa J.

    2015-01-01

    Writing intensive first-year seminars are well situated within the curriculum to teach about issues like cheating and plagiarism. Although most research on academic integrity focuses on how--and how much--students cheat, we take a different approach. We assess whether participation in writing intensive first-year seminars produces measurable…

  1. A Preliminary Comparison of Student and Professional Motivations for Choosing Information Systems

    Science.gov (United States)

    Brooks, Nita; Korzaan, Melinda; Ceccucci, Wendy

    2014-01-01

    Demand for qualified information systems professionals continues to rise. Additionally, over the past decade, enrollment in information systems-related educational programs has declined. In order to understand why and to better understand how to position information systems undergraduate programs to recruit and retain students, this study provides…

  2. LETs and NETs: Exploring How Teachers from Diverse Cultural Backgrounds Impact Student Motivation and Preferences

    Science.gov (United States)

    Wong, Ruth

    2014-01-01

    This paper, an exploratory case study, examines how students' preferences and motivation to learn English are influenced by their perceptions of teaching practices--both of native English teachers and local English teachers. To better understand the context of this research question, this study adopts a method of triangulation in collecting data:…

  3. EXTENSIVE LISTENING: LET STUDENTS EXPERIENCE LEARNING BY OPTIMIZING THE USE OF AUTHENTIC MATERIALS

    Directory of Open Access Journals (Sweden)

    Yulia Hapsari

    2014-10-01

    Full Text Available In a country like Indonesia, one of challenges in learning English as a foreign language is a lack of exposure of English in its authentic sense. The use of authentic materials seems to be an option to cope with this situation. One of the ways to optimize the use of the authentic materials to trigger students to experience learning and to enhance their active involvement in the learning process is by using it in extensive listening activities. Through extensive listening by using authentic materials, students are exposed to real native speech in meaningful language use. As the result, difficulties in listening gradually disappear.  In order to put the idea into practice, the first thing to do is to set objectives of each meeting based on core vocabulary and grammar that are suitable for the learners using comprehensible input principle as the basic consideration. Second, selecting authentic materials that suit the objectives and that give exposure to formulaic language and meaningful language use. Then, preparing activities in which the instruction is reasonable and lead to sufficient practice to develop fluency. Finally, synchronize teaching activities to increase students’ motivation to learn. As a follow up activities, students are informed and eventually involved in the whole process. Thus, students experience learning and actively involved in their learning process.

  4. Let's Go Riding in the Car. An ESL/Geography Module. Teacher's Guide [and] Student Booklet.

    Science.gov (United States)

    Carver, Peter; Howard, Joan

    The teacher's guide to a set of instructional materials for an English as a second language unit on automobiles as a form of transportation focuses on the history of the auto's development, importance to the Canadian economy, and impact on the lives of Canadians. The target audience is secondary students at intermediate and advanced English…

  5. Factors that Influence Students in Choosing Physics Programmes at University Level: the Case of Greece

    Science.gov (United States)

    Meli, Kalliopi; Lavidas, Konstantinos; Koliopoulos, Dimitrios

    2018-04-01

    Low enrolment in undergraduate level physics programmes has drawn the attention of the relevant disciplines, education policy-makers, and researchers worldwide. Many reports released during the previous decades attempt to identify the factors that attract young people to study science, but only few of them focus explicitly on physics. In Greece, in contrast to many other countries, physics departments are overflowing with young students. However, there are two categories of students: those for whom physics was the optimal choice of a programme ("choosers") and those for whom physics was an alternative choice that they had to settle for. We suggest that the latter category be called "nearly-choosers," in order to be differentiated from choosers as well as from "non-choosers," namely those candidates that did not apply to a physics programme at all. We are interested in the factors that attract high school students to study physics and the differences (if any) between choosers and nearly-choosers. A newly formed questionnaire was distributed within a Greek physics department (University of Patras), and the students' responses (n = 105) were analysed with exploratory factor analysis and specifically principal component analysis so as to extract broad factors. Three broad factors have arisen: school-based, career, and informal learning. The first two factors proved to be motivating for pursuing a degree in physics, while the third factor appeared to have a rather indifferent association. t tests and Pearson correlations indicated mild differentiations between choosers and nearly-choosers that pertain to school-based influences and informal learning.

  6. Bully, Bullied, Bystander. . . and beyond: Help Students Choose a New Role

    Science.gov (United States)

    Coloroso, Barbara

    2011-01-01

    Bullying is seldom the only factor in a teenager's suicide. Often, mental illness and family stresses are involved. But bullying does play a role in many cases. These students feel that they have no way out of the pain heaped on them by tormentors--no one to turn to, no way to tell others. So they turn the violence inward with a tragic and final…

  7. Choosing Beauty

    NARCIS (Netherlands)

    Friederich, Simon

    2017-01-01

    Reasoning that takes into account self-locating evidence in apparently plausible ways sometimes yields the startling conclusion that rational credences are such as if agents had bizarre causal powers. The present paper introduces a novel version of the Sleeping Beauty problem-Choosing Beauty-for

  8. Let's start learning radiation. Supplementary material on radiation for secondary school students

    International Nuclear Information System (INIS)

    Watanabe, Yoko; Yamashita, Kiyonobu; Shimada, Mayuka

    2015-01-01

    The Japan Atomic Energy Agency has been organizing training programs for engineers in Asian countries introducing nuclear technology. In 2012, we launched a course ‘Basic Radiation Knowledge for School Education’ as we thought disseminating accurate knowledge on radiation to school students and public would also be important in those countries after Fukushima-Daiichi nuclear power station accident. Ministry of Education, Culture, Sports, Science and Technology - Japan published supplemental learning material on radiation for secondary school students and teachers in Japanese in October 2011. Since the learning material is designed to give a clear explanation of radiation and covers various topics, we thought it would also be beneficial for young students in the world if a learning material in English was available. Therefore, we made a new learning material in English using the topics covered in supplemental learning material on radiation in Japanese as a reference. This learning material has been favourably evaluated by the International Atomic Energy Agency (IAEA) and will be widely used as a practical educational tool in many countries around the world through the IAEA. (author)

  9. Students' satisfaction with a dental summer programme and importance of influencing factors for choosing dentistry as their career.

    Science.gov (United States)

    Suen, R P C; Lai, S M L; Bridges, S; Chu, C H

    2014-05-01

    To study the students' satisfaction with the week-long summer programme and the importance of common influencing factors (IFs) for choosing dentistry as their career. Anonymous questionnaire was given to all 214 participants in July of 2011 and 2012. Demographic information including gender, age and education level was collected. The students were asked about their satisfaction with the programme with separate ratings for learning experiences, including hands-on workshops (HOW); clinic observations (CO); problem-based learning tutorials (PBL); and lectures (L). They also rated the relative importance of the ten common IFs. The Friedman test was used to study the order of their preferences of the programme's activities. The Chi-square test was used to study the influence of their demographic factors on the importance of the IFs. A total of 208 students returned their questionnaires. The majority were below the age of 18 (81%), and 44% were studying in an international school. Most of the students (96%) were satisfied with the programme overall. They liked the HOWs and COs more than the PBL tutorials and Ls. 'Altruism' and 'medical/health care career' were the two most important IFs overall. 'Altruism' and 'past experience with dentist' were considered more important by those aged 18 or above. 'Past experience with dentist' and 'working with hands' were considered more important by the international school students. Most participants were satisfied with the summer programme. They preferred practical, skill-based activities to knowledge-based activities. The importance of some IFs was associated with age and education system. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. The Factors Influencing Consumer Purchase Decision in Choosing Tablet Products of Iba Students

    OpenAIRE

    Tumewu, Ferdinand J.; Saerang, David Paul Elia; Korompis, Caecilia Eva Martina

    2014-01-01

    Youth in this modern era, related with their intention to get information access quickly. Nowadays, there is a popular gadget that used by many people which called tablet. Tablet is a combination of cell phones and laptop. The students of IBA program as the youth who are studying, they need to have gadget which not only can be used to access the internet or social media, but also can help them in college activity. The objective of this research is to know what factors that influencing consume...

  11. Letting students discover the power, and the limits, of simple models: Coulomb's law

    Science.gov (United States)

    Bohacek, Peter; Vonk, Matthew; Dill, Joseph; Boehm, Emma

    2017-09-01

    The inverse-square law pops up all over. It's a simplified model of reality that describes light, sound, gravity, and static electricity. But when it's brought up in class, students are often just handed the equations. They rarely have an opportunity to discover Coulomb's law or Newton's law of gravitation for themselves. It's not hard to understand why. A quantitative demonstration of Coulomb's law can be difficult. The forces are smaller than many force sensors can measure and static electricity tends to be finicky. In addition, off-the-shelf units are expensive or difficult to use. As a result, many instructors skip this lab in favor of qualitative demonstrations or simulations. Adolf Cortel sought to remedy this by designing a straightforward experiment for measuring Coulomb's law using charged metalized-glass spheres (Christmas ornaments) and an electronic balance. Building on Cortel's design, we've made a series of video-based experiments that students can use to discover the relationships that underlie electric force.

  12. Ombuds’ corner: Let's not confuse students and fellows with missing staff

    CERN Multimedia

    Vincent Vuillemin

    2013-01-01

    One of the main missions of CERN is education. Several programmes are dedicated to training students. Others, like the Fellowship programme, offer graduates to start a career and become professionals in their fields. All these young and fresh people provide very valuable contributions to our Organization.   At the same time, it is important to remember that they (especially the students) are here to learn from our professional staff for their future career. This is the correct exchange: they bring their dedicated work to our projects and they gain experience by working with our staff. There’s no better way to learn than on-the-job. However they should not be considered as missing staff, with the exact same requirements expected from the CERN staff. Potential missing staff in some areas is a separate issue, and educational programmes are not designed to make up for it. On-the-job learning and training are not separated but dynamically linked together, benefiting to both par...

  13. Let's go formative: continuous student ratings with Web 2.0 application Twitter.

    Science.gov (United States)

    Stieger, Stefan; Burger, Christoph

    2010-04-01

    Student ratings have been a controversial but important method for the improvement of teaching quality during the past several decades. Most universities rely on summative evaluations conducted at the end of a term or course. A formative approach in which each course unit is evaluated may be beneficial for students and teachers but has rarely been applied. This is most probably due to the time constraints associated with various procedures inherent in formative evaluation (numerous evaluations, high amounts of aggregated data, high administrative investment). In order to circumvent these disadvantages, we chose the Web 2.0 Internet application Twitter as evaluation tool and tested whether it is useful for the implementation of a formative evaluation. After a first pilot and subsequent experimental study, the following conclusions were drawn: First, the formative evaluation did not come to the same results as the summative evaluation at the end of term, suggesting that formative evaluations tap into different aspects of course evaluation than summative evaluations do. Second, the results from an offline (i.e., paper-pencil) summative evaluation were identical with those from an online summative evaluation of the same course conducted a week later. Third, the formative evaluation did not influence the ratings of the summative evaluation at the end of the term. All in all, we can conclude that Twitter is a useful tool for evaluating a course formatively (i.e., on a weekly basis). Because of Twitter's simple use and the electronic handling of data, the administrative effort remains small.

  14. Factors influencing Saudi Arabian optometry candidates' career choices and institution of learning. Why do Saudi students choose to study optometry?

    Science.gov (United States)

    Osuagwu, Uchechukwu L; Briggs, Stella T; Chijuka, John C; Alanazi, Saud A; Ogbuehi, Kelechi C

    2014-09-01

    Optometry is a primary health-care profession (PHCP) and this study aimed to elucidate the factors influencing the choice of optometry as a career for Saudi students, the students' perceptions of optometry and the effect of gender. Two hundred and forty-seven students whose average age was 21.7 ± 1.5 (SD) years and who are currently enrolled in two colleges of optometry in Saudi Arabia--King Saud University (KSU) and Qassim University (QU)--completed self-administered questionnaires. The survey included questions concerning demography, career first choice, career perception and factors influencing career choices. The response rate was 87.6 per cent and there were 161 male (64.9 per cent) students. Seventy-nine per cent of the participants were from KSU (males and females) and 20.6 per cent were from QU (only males). Seventy-three per cent come from Riyadh and 19 per cent are from Qassim province. Regarding the first choice for their careers, the females (92 per cent) were 0.4 times more likely (p = 0.012) to choose optometry than males (78.3 per cent). The males were significantly more likely to be influenced by the following factors: the Doctor of Optometry (OD) programs run at both universities, good salary and prospects (p optometry. Females were more likely to opt for a career in optometry and males were more likely to be influenced by the new OD programs, good salary and job prospects. Service provision to others in the community was a primary motivation to opt for a career in optometry among young Saudis. © 2014 The Authors. Clinical and Experimental Optometry © 2014 Optometrists Association Australia.

  15. Students as Researchers: What and Why Seventh-Grade Students Choose to Write When Investigating Their Own Research Question

    Science.gov (United States)

    Bjørkvold, Tuva; Blikstad-Balas, Marte

    2018-01-01

    All scientists depend on both reading and writing to do their scientific work. It is of paramount importance to ensure that students have a relevant repertoire of practices they can employ when facing scientific content inside and outside the school context. The present study reports on students in seventh grade acting as researchers. Over an…

  16. To Choose or Not to Choose Science

    DEFF Research Database (Denmark)

    Holmegaard, Henriette Tolstrup; Madsen, Lene Møller; Ulriksen, Lars

    2014-01-01

    In the literature, there is a general concern that a less number of students choose to study science, technology, engineering or mathematics (STEM). This paper presents results from a Danish longitudinal study which examines students’ choice of whether or not to continue studying STEM after upper......-secondary school. In particular, this study focuses on students who held an STEM subject as one of their favourite subjects at secondary educational level, but who chose not to study STEM at the tertiary level. This paper explores how students’ perceptions of STEM relate to their identity work. The data used...

  17. The students' interest for 2012 and 2013 cohort in construction engineering vocational education program Universitas Negeri Semarang in choosing the subject specialization

    Science.gov (United States)

    Julianto, Eko Nugroho; Salamah, Ummu

    2017-03-01

    On the 2012 curriculum, Vocational Education Program Universitas Negeri Semarang allowed the students to choose subjects for their specialization according to their ability. The subject specialization was given at the 6th semester to provide students in performing field work experience. Each course has its own enthusiasts specialization, students have certain considerations in selecting the course. The consideration of each of them is different from one another because they have their own talents, interests, aspirations and perceptions or a different view in assessing a subject specialization offered by Construction Engineering Vocational Education Program. The purpose of this study was to determine the amount of interest caused by intrinsic and extrinsic factors on 2012 and 2013 students' cohort in selecting subjects of specialization. This research is descriptive with quantitative approach, which is carried out to determine the magnitude of the interest students in choosing courses of specialization. Research conducted at the Civil Engineering Department Universitas Negeri Semarang, with research subjects that students PTB forces in 2012 and 2013, with a total sample of 87 students. The results showed that the interest of the student of 2012 and 2013 in selecting subjects of specialization is equal to 68.06% with the criteria are interested in contributions from intrinsic factors indicate the yield at 35.48% and 64.52% extrinsic factors.

  18. Let??s teach geometry

    OpenAIRE

    Ca??adas, Mar??a C.; Molina, Marta; Gallardo, Sandra; Mart??nez-Santaolalla, Manuel J.; Pe??as, Mar??a

    2010-01-01

    In this work we present an activity for High School students in which various mathematical concepts of plane and spatial geometry are involved. The final objective of the proposed tasks is constructing a particular polyhedron, the cube, by using a modality of origami called modular origami.

  19. Why Choose Teaching? an International Review of Empirical Studies Exploring Student Teachers' Career Motivations and Levels of Commitment to Teaching

    Science.gov (United States)

    Heinz, Manuela

    2015-01-01

    Why do individuals all over the world choose to become school teachers? What motivates them to become educators of young people, and how committed are they to this cause when they enter their teacher education courses? Considering that teacher motivation and commitment have been identified as crucial factors for the future success of education and…

  20. Association between rural clinical clerkship and medical students' intentions to choose rural medical work after graduation: A cross-sectional study in western China.

    Science.gov (United States)

    Liu, Jinlin; Zhu, Bin; Mao, Ying

    2018-01-01

    A large number of programs have been implemented in many countries to increase the healthcare workforce recruitment in rural and remote areas. Rural early exposure programs for medical students have been shown to be effective strategies. However, no related studies have been reported before in China. This study was carried out to determine the association between medical students' participation in rural clinical clerkships and their intentions to choose rural medical work after graduation from western medical schools in China. Based on a two-stage random sampling method, the cross-sectional survey was carried out in ten western provinces in China. A brief questionnaire filled in by medical students was used for data collection. A total of 4278 medical students participated in the study. The response rate was approximately 90.34%. Pearson's chi-squared tests and binary logistic regression analyses were performed for data analyses. Approximately 52.0% of medical students disclosed intentions to work in rural medical institutions after graduation. Only one in five participants had experience with a rural clinical clerkship. Rural clinical clerkships were significantly associated with medical students' intentions to work in rural medical institutions (OR: 1.24, 95%CI: 1.05-1.46); further analyses indicated that such clerkships only had a significant impact among the medical students with an urban background (OR: 2.10, 95%CI: 1.48-2.97). In terms of the sociodemographic characteristics, younger age, low level of parental education, majoring in general practice, and studying in low-level medical schools increased the odds of having intentions to engage in rural medical work among medical students; however, rural origins was the only positive univariate predictor. In addition, the predictors of intentions to choose rural medical work were different between medical students with a rural background and those with an urban background. Rural clinical clerkship is likely to

  1. "Let Your Data Tell a Story:" Climate Change Experts and Students Navigating Disciplinary Argumentation in the Classroom

    Science.gov (United States)

    Walsh, Elizabeth Mary; McGowan, Veronica Cassone

    2017-01-01

    Science education trends promote student engagement in authentic knowledge in practice to tackle personally consequential problems. This study explored how partnering scientists and students on a social media platform supported students' development of disciplinary practice knowledge through practice-based learning with experts during two pilot…

  2. Dietetics students' ability to choose appropriate communication and counseling methods is improved by teaching behavior-change strategies in computer-assisted instruction.

    Science.gov (United States)

    Puri, Ruchi; Bell, Carol; Evers, William D

    2010-06-01

    Several models and theories have been proposed to help registered dietitians (RD) counsel and communicate nutrition information to patients. However, there is little time for students or interns to observe and/or participate in counseling sessions. Computer-assisted instruction (CAI) can be used to give students more opportunity to observe the various methods and theories of counseling. This study used CAI simulations of RD-client communications to examine whether students who worked through the CAI modules would choose more appropriate counseling methods. Modules were created based on information from experienced RD. They contained videos of RD-patient interactions and demonstrated helpful and less helpful methods of communication. Students in didactic programs in dietetics accessed the modules via the Internet. The intervention group of students received a pretest module, two tutorial modules, and a posttest module. The control group only received the pretest and posttest modules. Data were collected during three semesters in 2006 and 2007. Two sample t tests were used to compare pretest and posttest scores. The influence of other factors was measured using factorial analysis of variance. Statistical significance was set at Pcommunication and counseling methods for dietetics students. 2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved.

  3. General Practitioner Education Reform in China: Most Undergraduate Medical Students do not Choose General Practitioner as a Career Under the 5+3 Model

    Directory of Open Access Journals (Sweden)

    Shuang Wang

    2018-06-01

    Full Text Available Purpose: In order to train more high-level general practitioners (GPs to work in primary care institutions, China launched the 5+3 model in 2015 as a way to educate GPs nationwide. In this study, we investigated the awareness of the 5+3 model, career choices after graduation, and influences on GP career choice of undergraduate medical students from Zhengzhou University. Methods: The study population consisted of 288 undergraduate medical students from Zhengzhou University. We explored the students׳ awareness of the 5+3 model, career choices after graduation, influences on general practitioner career choice and mental status by using a self-report questionnaire and the Chinese version of the 21-item Depression Anxiety Stress Scale. Results: We found 34.2% of students did not understand the new policy. Only 23.2% of students would choose to work as a GP after graduation, and those tended to be female, to have a monthly family income less than 4000 ¥, or to be from rural areas. Only 10% of undergraduate medical students expressed a preference to work at primary care institutions. The participants showed higher anxiety and stress scores than did a previously published group of Chinese college students, and those who chose to pursue higher education had more anxiety and stress than those who decided to become general practitioners. Discussion: More efforts should be made to popularize the 5+3 model and mental intervention among medical students. More efforts should be tried to increase the income/welfare benefits and strengthen the infrastructure of primary care institutions to attract more medical students. Keywords: 5+3 model, General practitioner, Health care reform, Hierarchical medical system

  4. Students' Motivations for Choosing (Or Not) to Study Portuguese: A Survey of Beginning-Level University Classes

    Science.gov (United States)

    Bateman, Blair E.; de Almeida Oliveira, Desirée

    2014-01-01

    Although previous literature has discussed ways of promoting the study of Portuguese, to our knowledge no study has ever directly surveyed students to ascertain why they chose to learn the language. This study reports on a survey of the motivations of first- and second-year Portuguese students to study the language, and contrasts their motivations…

  5. Motivation and Expectations in Choosing Elementary Teaching Education Studies. A Study of Three Classes of First-Year Mexican Students

    Directory of Open Access Journals (Sweden)

    José María García Garduño

    2006-11-01

    Full Text Available The purpose of this study was to identify changes in the type of motivation involved in three generations of teacher-trainees. Participants were students of a Mexican public teaching school of different curriculum programs: 144 students of Plan 75, 140 of Plan 84, 116 of Plan 97. The students were asked to complete a questionnaire for entering the school in order to identify their motivations and expectations that they had after finishing school. The results indicate that almost half of the population chose the teaching profession because of extrinsic reasons. About 40% of the students had the expectation to pursue college studies not related to the teaching profession. There were differences among the classes. Plan 97 had less students who chose teaching for extrinsic motives. The results are discussed.

  6. `Let your data tell a story:' climate change experts and students navigating disciplinary argumentation in the classroom

    Science.gov (United States)

    Walsh, Elizabeth Mary; McGowan, Veronica Cassone

    2017-01-01

    Science education trends promote student engagement in authentic knowledge in practice to tackle personally consequential problems. This study explored how partnering scientists and students on a social media platform supported students' development of disciplinary practice knowledge through practice-based learning with experts during two pilot enactments of a project-based curriculum focusing on the ecological impacts of climate change. Through the online platform, scientists provided feedback on students' infographics, visual argumentation artifacts that use data to communicate about climate change science. We conceptualize the infographics and professional data sets as boundary objects that supported authentic argumentation practices across classroom and professional contexts, but found that student generated data was not robust enough to cross these boundaries. Analysis of the structure and content of the scientists' feedback revealed that when critiquing argumentation, scientists initiated engagement in multiple scientific practices, supporting a holistic rather than discrete model of practice-based learning. While traditional classroom inquiry has emphasized student experimentation, we found that engagement with existing professional data sets provided students with a platform for developing expertise in systemic scientific practices during argument construction. We further found that many students increased the complexity and improved the visual presentation of their arguments after feedback.

  7. Let's Talk about Race, Baby: How a White Professor Teaches White Students about White Privilege and Racism

    Science.gov (United States)

    Heinze, Peter

    2008-01-01

    There are a variety of methods by which the themes of White privilege and racism can be presented to White students. By using the concept of racial identity a continuum of racism can be considered. Furthermore, addressing White privilege and racism in the context of a multicultural psychology course allows White students to have a greater…

  8. Underrepresented minority students' experiences at Baylor College of Dentistry: perceptions of cultural climate and reasons for choosing to attend.

    Science.gov (United States)

    McCann, Ann L; Lacy, Ernestine S; Miller, Barbara H

    2014-03-01

    A study was conducted at Texas A&M University Baylor College of Dentistry (TAMBCD) in fall 2011 to identify the reasons underrepresented minority (URM) students chose to attend TAMBCD, the factors that supported their success as enrolled students, and their perceptions of the institution's cultural climate. A survey distributed online to all URM students received a 79 percent response rate (129/164). The respondents were primarily Hispanic (62 percent Mexican American and other Hispanic) and African American (33 percent) and had attended a college pipeline program (53 percent). The top reasons these students chose TAMBCD were reputation, location, and automatic acceptance or familiarity from being in a predental program. Alumni had most influenced them to attend. Regarding support services, the largest percentage reported not using any (44 percent); personal advising and tutoring were reported to be the most commonly used. In terms of climate, discrimination was reported by 22 percent (n=29), mostly from classmates and clinical faculty. The majority (87 percent) reported their cultural competence program was "effective" and agreed that faculty (83 percent), staff (85 percent), and students (75 percent) were culturally competent. Overall, the students were "satisfied" with how they were treated (88 percent), their education (91 percent), and the services/resources (92 percent). This information is being used to continue to improve the school's cultural climate and to conduct a broader assessment of all students.

  9. Choosing Science: A Mixed-Methods Study of Factors Predicting Latino and Latina High School Students' Decisions to Pursue Science Degrees

    Science.gov (United States)

    Stein, Rachel S.

    Latino/as are an increasingly large subset of the United States population; however, they continue to be underrepresented in science careers. Because of this increase, research regarding Latino/as has improved, but there are still many gaps in regards to gender-specific predictors to pursue science careers. To address this lack of literature, the purpose of this study is to extend previous research and to develop a model of variables that significantly contribute to science career choice among Latino and Latina students when they graduate from high school. In particular the study addressed the following research questions: (1) What are the differences in science outcomes for Latino and Latina students? (2) What are the differences in factors involved in science outcomes for Latino and Latina students? (3) For Latino and Latina students what are the differences in the factors that predict students' choice to pursue a science degree and/or high scores on the Future Plans in Science Scale? (4) What are the differences in how Latino and Latina students experience science, which account for high achieving students to choose to pursue a science major? This study utilized an explanatory mixed-method approach to examine how cognitive, institutional, and motivational factors may be interrelated and play a role in Latino/as choice to pursue science. The first phase of the study incorporated the collection of survey and database information from 12th grade students at two Southern California high schools. The second phase of the study utilized follow-up focus group interviews to explore the specific differential experiences and views of Latino and Latina students. The results of the study demonstrated multiple significant predictors. Science self-concept and views towards science outside of school were the most significant predictors of students' choice to pursue science. Male students also had major predictors of Spanish proficiency, teacher encouragement, religious views

  10. Countering the influence of cultural hegemony on choosing a nursing career: a group-mentoring approach for student recruitment.

    Science.gov (United States)

    Kneipp, Shawn M; Rowsey, Pamela J; Giscombe, Cheryl; Hodges, Eric A; Fowler, Tamryn; Alexander, Rumay

    2014-05-01

    Extensive literature exists that demonstrates the influence of social cues and interpersonal interactions with influential others on student career choices. This article applies Gramsci's political views of hegemony and counterhegemony to situate student descriptions of their experiences and the goals of a group-mentoring session designed to address the culturally hegemonic symbolic cues and interpersonal interactions that can negatively influence a student's desire to select a career in nursing. Specifics around the development, implementation, and evaluation of the group-mentoring session, as part of a broader school-wide culture to promote diversity and as a larger program to increase the diversity of the nursing workforce, are described. Copyright 2014, SLACK Incorporated.

  11. Let's Talk About Water: Using Film Screenings to Engage Students and the Public in Water Science and Policy

    Science.gov (United States)

    Saleem Arrigo, J. A.; Berry, K.; Hooper, R. P.; Lilienfeld, L.

    2013-12-01

    "Let's Talk about Water" is a film symposium designed to bring together experts and the public to talk about the complex water issues facing society. The format of the event is quite simple: a panel of experts and the audience view a water documentary (such as "FLOW", "Liquid Assets", or "Gasland") together and there is an extended moderated discussion period following the film between the panel and the audience. Over the course of several events, we have developed best practices that make this simple format very effective. A film creates a context of subject and language for the discussion--it gets the audience and the panel on the same page. The moderators must actively manage the discussion, both challenging the panelists with follow up questions, asking questions to simplify the language the expert is using, and passing a question among panelists to bring out different points of view. The panelists are provided with the film in advance to view and, most importantly, meet the day before the event to discuss the film. This makes for a much more convivial discussion at the event. We have found that these discussions can easily be sustained for 90 to 120 minutes with active audience participation. We have found key element of the event is local relevance. Films should be carefully chosen to resonate with the audience, and the local host is critical in defining the audience, goals and identified panel members. Having local experts from universities and representatives from local water authorities and environmental groups bring a sense of community and a confidence in the audience that the panel members have local knowledge that is important for sustaining discussion. The discussion begins with points raised by the movie (are these issues real? Do they apply here? What are the scientific, engineering, and policy solutions to these problems?) and then segues into a discussion about career opportunities in the water sector, volunteer opportunities in the community or

  12. Do Work Placements Improve Final Year Academic Performance or Do High-Calibre Students Choose to Do Work Placements?

    Science.gov (United States)

    Jones, C. M.; Green, J. P.; Higson, H. E.

    2017-01-01

    This study investigates whether the completion of an optional sandwich work placement enhances student performance in final year examinations. Using Propensity Score Matching, our analysis departs from the literature by controlling for self-selection. Previous studies may have overestimated the impact of sandwich work placements on performance…

  13. Letting the Cat out of the Bag: EFL College Students' Attitudes towards Learning English Idioms

    Science.gov (United States)

    Al-Houti, Shorouq K.; Aldaihani, Sultan M.

    2018-01-01

    Learning idioms is an uphill battle for many language learners. Thus, this quantitative study aims to shed light on English as Foreign Language (EFL) college students' attitudes towards idiom learning. Specifically, the study is interested in revealing their attitudes towards (1) the importance of idiom learning, (2) the difficulties of idiom…

  14. A survey of how and why medical students and junior doctors choose a career in ENT surgery.

    Science.gov (United States)

    Bhutta, M; Mandavia, R; Syed, I; Qureshi, A; Hettige, R; Wong, B Y W; Saeed, S; Cartledge, J

    2016-11-01

    To ascertain determinants of an interest in a career in ENT surgery through a survey of medical students and junior doctors. A survey was administered, comprising Likert scales, forced response and single option questions, and free text responses, at five different courses or events for those interested in a career in ENT. The survey had an 87 per cent response rate; respondents consisted of 43 applicants for national selection, 15 foundation doctors and 23 medical students. The most important factors that encourage ENT as a career included: the variety of operative procedures, work-life balance, inherent interest in this clinical area and inspirational senior role models. Exposure to ENT in undergraduate or post-graduate training is critical in deciding to pursue this specialty. It is important to promote those aspects of ENT surgery that attract people to it, and to argue for greater exposure to ENT during undergraduate and post-graduate training.

  15. Encouraging Students with Different Profiles of Perceptions to Pursue Science by Choosing Appropriate Teaching Methods for Each Age Group

    Science.gov (United States)

    Potvin, Patrice; Hasni, Abdelkrim

    2017-06-01

    This research aimed at identifying student profiles of perceptions by means of a clustering method using a validated questionnaire. These profiles describe students' attraction to science and technology (S&T) studies and careers as a variable driven by school S&T self-concept and interest in school S&T. In addition to three rather predictable student profiles (confident enthusiast, average ambitious, and pessimistic dropout), the fourth fairly well-populated profile called confident indifferent was produced. Our second and third research questions allowed us to describe each profile in terms of the instructional methods to which their population was exposed (including the degree to which they were actively involved) and the instructional methods to which they would like more exposure. An analysis of the evolution of the profiles' population over time is also presented. The results suggest that pedagogical variety and active involvement in the decision to pursue S&T are important. The perception of the utility and importance of S&T both in and out of school may also play an important role in these decisions. Minor pedagogical preferences were also found in certain age groups.

  16. "Let's get down to business: a validation study of the Psychopathic Personality Inventory among a sample of MBA students.".

    Science.gov (United States)

    Heinze, Peter; Allen, Rhianon; Magai, Carol; Ritzler, Barry

    2010-08-01

    While the Psychopathic Personality Inventory (PPI) has gained increasing attention as a measure of noncriminal psychopathy, absent has been research involving samples including business people. This study investigated the validity of the PPI with such a population by examining the association between psychopathic traits and moral decision-making among MBA students. Sixty-six MBA students were assessed using the PPI, the MACH-IV (a measure of Machiavellianism), the Ethical Position Questionnaire (EPQ), and the Defining Issues Test (DIT-2). Only PPI Machiavellian Egocentricity was associated with level of post-conventional moral reasoning. MACH-IV Machiavellianism was a stronger predictor of the Subjectivist ethical position than were PPI subscales. However, a combination of MACH-IV Machiavellianism and four PPI scales accounted for 46% of the variance in Subjectivism. Results suggested that Machiavellian Egocentricity and Machiavellianism are distinct constructs. Benning, Patrick, Hicks, Blonigen, & Krueger (2003)'s two factor model of the PPI was also supported. In general, the findings provided further validation for the PPI as a tool for assessing psychopathic traits among "mainstream" individuals, including business people.

  17. Let them eat cake!

    OpenAIRE

    Samson, Audrey; Gallardo, Francisco; FRAUD, -

    2017-01-01

    Let them eat cake!' is a food-led event serving an edible imaginary of a Facebook profile. In early 2012, Facebook conducted massive scale emotional contagion by manipulating the emotional expressions in the News Feeds of 689,003 users. This exemplifies how the governability and the biopolitics of everyday life flow through the many layers of shared images, liked videos, protocols, and hyperlinks, all orchestrated by the Facebook News Feed algorithm. 'Let them eat cake!' proposes a gustatory ...

  18. Let's move salad bars to schools: a public-private partnership to increase student fruit and vegetable consumption.

    Science.gov (United States)

    Harris, Diane M; Seymour, Jennifer; Grummer-Strawn, Laurence; Cooper, Ann; Collins, Beth; DiSogra, Lorelei; Marshall, Andrew; Evans, Nona

    2012-08-01

    Few school-age youth consume the recommended amounts of fruits and vegetables, and increasing fruit and vegetable intake in children and adolescents is an important public health goal to maintain long-term good health and to decrease risk of chronic disease and obesity. School salad bars are an important tool to promote fruit and vegetable consumption among schoolchildren. Studies show that introduction of school salad bars increases the amount and variety of fruits and vegetables consumed by children in schools. However, many schools cannot afford the capital investment in the salad bar equipment. In 2010, the National Fruit & Vegetable Alliance (NFVA), United Fresh Produce Association Foundation, the Food Family Farming Foundation, and Whole Foods Market launched Let’s Move Salad Bars to Schools (LMSB2S) in support of First Lady Michelle Obama’s Let’s Move! initiative. The goal of LMSB2S is to place 6000 salad bars in schools over 3 years. As of June, 2012, over 1400 new salad bar units have been delivered to schools across the United States, increasing access to fruits and vegetables for over 700,000 students. Any K through 12 school district participating in the National School Lunch Program is eligible to submit an application at www.saladbars2schools. org/. Requests for salad bar units ($2625 each unit) are fulfilled through grassroots fund raising in the school community and through funds raised by the LMSB2S partners from corporate and foundation sources. LMSB2S is a model for coalition-building across many government, nonprofit, and industry partners to address a major public health challenge.

  19. Choosing Wood Burning Appliances

    Science.gov (United States)

    Information to assist consumers in choosing a wood burning appliance, including types of appliances, the differences between certified and non-certified appliances, and alternative wood heating options.

  20. A systematic review of the experiences of undergraduate nursing students choosing to study at an English speaking university outside their homeland.

    Science.gov (United States)

    Terwijn, Ruth; Pearce, Susanne; Rogers-Clark, Catherine

    Increasingly overseas students are attending university nursing programs in English-speaking countries to gain additional tertiary qualifications that may not be available in their homeland and also to fill the international nursing shortfall. For these students, some common issues identified and affirmed in qualitative research papers include loneliness, discriminatory experiences, developing communication, and academic skills. This systematic review will help identify and synthesise current issues through exploring the existing literature, giving an insight into the lives of international nursing students. Given the large and increasing number of these students, it is important to acknowledge and improve learning and other outcomes for them. The objective of this systematic review was to determine the best available evidence in relation to the experiences of undergraduate nursing students choosing to study at an English speaking university outside their homeland. This review sought high quality studies aimed at exploring the experience of undergraduate nursing students studying outside their homeland at an English speaking university. Both qualitative research studies and opinion-based text were considered for this review. An extensive search of the literature was conducted to identify research studies published between January 1990 and April 2011 in English and indexed in 37 major databases. All included articles were assessed independently by two reviewers (RT and SP), using the appropriate critical appraisal tool from the Joanna Briggs Institute. Data were extracted from included papers using appropriate standardised data extraction tools developed by the Joanna Briggs Institute. Data from qualitative studies and textual and opinion papers were meta-synthesised separately using standardised instruments. Data synthesis of all included studies involved the pooling of findings and then grouping into categories on a basis of similarity of meaning. The categories

  1. NEWS: Why choose science?

    Science.gov (United States)

    2000-05-01

    National concerns over the uptake of science subjects and an analysis of how school science departments together with careers programmes influence students' subject choices feature in a recent report from the UK's National Institute for Careers Education and Counselling. It points out that decisions on science subjects are taken very early in pupils' education, often well before the implications of those choices can be clearly understood. If pupils are to be encouraged to keep science options open, then both science teachers and careers advisers have important roles to play. Physics is in fact singled out in the report's recommendations as in need of special attention, due to its perceived difficulty both within the double-award science course and also at A-level. The lack of qualified teachers in physics is noted as a problem for schools and the many initiatives to address these issues should be encouraged according to the report, but within an overall high-profile and well funded national strategy for developing science education in schools. The report also notes that science teachers do not feel able to keep up with career information, whilst few careers advisers have a science background and have little opportunity to build up their knowledge of science syllabuses or of science and engineering careers. More contact between both types of specialist is naturally advocated. Copies of the full report, Choosing Science at 16 by Mary Munro and David Elsom, are available from NICEC, Sheraton House, Castle Park, Cambridge CB3 0AX on receipt of an A4 stamped (70p) addressed envelope. A NICEC briefing summary is also available from the same address (20p stamp required).

  2. Choosing Spouse in Iran

    Directory of Open Access Journals (Sweden)

    Seyed Zia'

    2015-03-01

    Full Text Available Each society and culture, according to its condition and requirements, makes special circumscriptions, criterions and norms in choosing a spouse. In every culture one may have several alternatives of his/her own opposite sex as a spouse, but spouse choosing is never accidental. In every culture, besides the circumscriptions which is due to the personal values and desires, there are some circumscriptions which are imposed by the society. Till some decades ago, the family organization was responsible for spouse choosing in Iran, but today each person's role has become more important; although cultural and social conditions have some effect on it. Therefore, nowadays spouse choosing is analyzed as an important social action and many theories have been provided for understanding the patterns of the spouse choosing. In this study and in a theoretical level, two important theories (similar spouses and different spouses are presented as two corrival theories and then according to similarities of these theories, the indicators of the study are made. After that, by using the survey research method throughout the country and the statistical population of five thousand people, we experimentally assess the indicators of the study and these two theories of the spouse choosing.            Results show the domination of the similar spouses' theory in Iran. They also show that approximately 90% of people in the external traits, 89% in the psycho-emotional traits, 93% in the personal traits, 68% in the social level characteristics and 88% in the religious beliefs, follow the patterns of the similar spouses' theory.The analytical results also conclusively show that different groups in Iran choose persons who have more similarity with them in the external, psycho-emotional and personal traits as well as the social level and religious characteristics. Although it should be noted that among men and women, the strangeness and weakness of these patterns are

  3. Choosing High School Courses with Purpose

    Science.gov (United States)

    Ayotte, Steve; Sevier, Sharon

    2010-01-01

    In choosing high school courses, students often seem to focus on everything except preparation for an intended major or career. They consider graduation requirements, weighted classes, easy classes...but rarely are these types of choices preparing students for postsecondary education. This article describes the "Career Companion Guide"…

  4. The Customer Cannot Choose

    NARCIS (Netherlands)

    A.C.D. Donkers (Bas)

    2013-01-01

    textabstractPeople can choose and they make many choices each and every day. However, most people are unaware of how strong their environment influences the choices they make. In his inaugural address, Bas Donkers highlights the impact of what people see (and what they don’t see), what people

  5. Let s make progress together!

    Science.gov (United States)

    Adriana, Mazare; Liliana, Gheorghian

    2015-04-01

    Let's make progress together! The "Theodor Balan" Secondary School in the urban area of Suceava County in northeastern Romania is involved in several different projects. In order to extend previous successful projects with the students, parents, teachers, businesses and local government representatives in science symposiums for civic projects within the concept of sustainable development, the school is continuing to develop various successful programs. "The battle" continues both in nature and in the classrooms, in order to preserve the environment and to discover new resources. To raise awareness about the importance of existing resources even at the level of individuals there is a constant concern for keeping up to date on what already exists and is well known, but at the same time to remove "barriers" and discover new horizons and resources. Scientific activities held in our school are an effective way to educate students and the community to which they belong. In our community, we discovered sources of drinking water polluted by nitrites from fertilizers used in agriculture. In order to inform and educate people in the area, our teachers have organized several educational activities. Its purpose was: -Knowledge of the importance of water for the environment and human health. -Reducing water pollution. Students have informed their families' about sustainable development acquired at school. In this way, the school manages to educate and change people's ideas. The ways and methods of adults' learning were practiced within a Grundtvig training course "It's never too late learning to learn" in February 2014, in Florence, Italy. The GIFT 2014 was a great occasion for the teachers and students, the county's educational department and the participants at the National Colloquia of Physics to discover new materials provided at the Conference and the latest news and topics in the world of science. The theme trips at the physics laboratories of "Alexandru Ioan Cuza

  6. Homo Ignorans: Deliberately Choosing Not to Know.

    Science.gov (United States)

    Hertwig, Ralph; Engel, Christoph

    2016-05-01

    Western history of thought abounds with claims that knowledge is valued and sought. Yet people often choose not to know. We call the conscious choice not to seek or use knowledge (or information) deliberate ignorance. Using examples from a wide range of domains, we demonstrate that deliberate ignorance has important functions. We systematize types of deliberate ignorance, describe their functions, discuss their normative desirability, and consider how they can be modeled. To date, psychologists have paid relatively little attention to the study of ignorance, let alone the deliberate kind. Yet the desire not to know is no anomaly. It is a choice to seek rather than reduce uncertainty whose reasons require nuanced cognitive and economic theories and whose consequences-for the individual and for society-require analyses of both actor and environment. © The Author(s) 2016.

  7. The Perception of Job-related Motivators When Choosing a Career in the Tourism and Hospitality Industry – A Comparative Study Between Polish and Spanish Students

    Directory of Open Access Journals (Sweden)

    Grobelna Aleksandra

    2017-06-01

    Full Text Available The recent rapid growth of the tourism and hospitality industries raises a question about the quantity and quality of the workforce needed in these sectors. In the tourism/hospitality industry, where most services are delivered directly by employees, competitive advantage is primarily attained through people (employees, who are perceived as an integral component of tourism experience. This creates challenges for an industry suffering from high rates of staff turnover, especially of young employees who leave their jobs after graduation, choosing other career paths.

  8. Choosing children: intergenerational justice?

    Science.gov (United States)

    Doyal, Len; McLean, Sheila

    2005-03-01

    In this discussion, we argue that the concept of intergenerational justice, usually used in environmental matters, is applicable to reproductive decisions also. Additionally, we propose that this permits certain reproductive choices to be made prior to conception or during the pregnancy, and that these choices should not be confined to clinical concerns. In particular, we argue that consideration of the interests of future children should be viewed from the perspective of objective well-being. That being the case, decisions about the sex of future offspring can, in terms of intergenerational justice, be legitimate. We do not argue that every reproductive choice is legitimate; for example it would not be legitimate deliberately to choose characteristics that prevent future children from potentially successful participation in social life.

  9. Choosing health, constrained choices.

    Science.gov (United States)

    Chee Khoon Chan

    2009-12-01

    In parallel with the neo-liberal retrenchment of the welfarist state, an increasing emphasis on the responsibility of individuals in managing their own affairs and their well-being has been evident. In the health arena for instance, this was a major theme permeating the UK government's White Paper Choosing Health: Making Healthy Choices Easier (2004), which appealed to an ethos of autonomy and self-actualization through activity and consumption which merited esteem. As a counterpoint to this growing trend of informed responsibilization, constrained choices (constrained agency) provides a useful framework for a judicious balance and sense of proportion between an individual behavioural focus and a focus on societal, systemic, and structural determinants of health and well-being. Constrained choices is also a conceptual bridge between responsibilization and population health which could be further developed within an integrative biosocial perspective one might refer to as the social ecology of health and disease.

  10. Choosing the right technology

    DEFF Research Database (Denmark)

    Milan, Christian; Nielsen, Mads Pagh; Bojesen, Carsten

    2014-01-01

    The use of renewable energy sources (RES) has continuously increased throughout the last decade. In the residential building sector the trend goes towards energy supply systems based on multiple RES. This is mainly due to political requirements, governmental subsidies and fuel price development....... These systems not only require an optimal design with respect to the installed capacities but also the right choice in combining the available technologies assuring a cost-effective solution. e aim of this paper is to present an optimization methodology for residential on-site energy supply systems based...... on mixed integer linear programming. The methodology chooses the right combination of technologies and sizes the components based on on-site weather data and expected consumption profiles. Through this approach the fluctuations of RES as well as the user behavior are taken into account already during...

  11. High-let radiation carcinogenesis

    International Nuclear Information System (INIS)

    Fry, R.J.M.; Powers-Risius, P.; Alpen, E.L.; Ainsworth, E.J.; Ullrich, R.L.

    1982-01-01

    Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20 to 30 rads

  12. LET-effects in DNA

    International Nuclear Information System (INIS)

    Kraft, G.; Taucher-Scholz, G.; Heilmann, J.

    1995-01-01

    The use of heavy particles in radiobiological experiments provides a fundamental tool to study the influence of different ionization densities and to prove the physical basis of models and theories. The knowledge of the interaction of high LET radiation (LET: linear energy transfer [keV/microm]) with biological matter is of great importance for the application of neutrons, protons and heavier ions in radiotherapy. It is also essential in radioprotection to estimate the risk in case of exposure to high LET radiation. In this contribution, an introductory view on the physical properties of ions is given and the cellular response to high LET radiation is summarized. Then the measurements of strand break induction of DNA in solution and in intracellular DNA are reported and compared to cell survival. The possibility of changes in the quality of the lesions is discussed and finally the present status of model calculations in comparison to the experiments is given

  13. Choosing a Field: How Graduate Student Choices of Field Sites Reflect Different Ideas of "Real" Anthropology in Colombia and the United States

    Science.gov (United States)

    Macia, Laura

    2012-01-01

    This paper examines the decisions and motivations of graduate students in cultural anthropology when defining the field sites and topics of their final projects. The decisions among students at the Universidad de los Andes in Colombia are contrasted with those at the University of Pittsburgh in the United States. A review of recent final projects…

  14. Digging up Classroom Dollars on DonorsChoose

    Science.gov (United States)

    Curriculum Review, 2006

    2006-01-01

    Back in 2000, Charles Best was teaching at Wings Academy, an alternative high school in the Bronx, when he got the idea for a Web site where teachers could solicit donations for class projects. With help from his students, DonorsChoose.org soon was born. Last year, the site won Amazon.com's Nonprofit Innovation Award. So far, DonorsChoose has…

  15. Undergraduate and Postgraduate Students in a North American University are Choosing to use Chat Reference Services for all Kinds of Reasons. A review of: Ward, David. “Why Users Choose Chat: A Survey of Behavior and Motivations.” Internet Reference Services Quarterly 10.1 (2005: 29-46.

    Directory of Open Access Journals (Sweden)

    Gill Needham

    2006-03-01

    Full Text Available Objective – To investigate reasons why undergraduate and postgraduate students choose to use chat reference services and their satisfaction with the experience. Design – User survey. Setting – Large academic library in the United States. Subjects – A total of 341 library users took part in the survey. Of these, 79 were graduate students, 215 undergraduates, 21 staff, 5 alumni and 21 members of the public. Method – A user survey form was posted on the library website for a period of one month (March 2003. Users of the chat reference service received an automatic closing message asking them to complete the survey. Responses were fed into a database to be analysed by the research staff. Additional data was also gathered about the behaviour of all users of the chat service during that period – both responders and non‐responders. Main results – The most popular reason for choosing to use a chat service was the desire for a speedy response, followed by ‘distance from the library’. Responders chose to use chat to ask a range of different kinds of questions. Nearly half (45% were looking for a specific resource and 23% were seeking help at the beginning of their research. There were notable differences between undergraduate and graduate students. Twice as many undergraduates as graduates used the service to help them get started on their research. Graduates were three times as likely as undergraduates to be using the service to address technical problems they were having with the website. Overall satisfaction with the service was extremely high, with 77.5% rating it 5 out of 5 and 94.5% giving it 4 or 5 out of 5. Conclusion – Chat reference services are popular with users primarily because they are quick and convenient. However, users expect that these services will be able to deal with all types of questions, including help with research. This challenges an assumption by library staff that the medium is only suitable for short

  16. How couples choose vasectomy.

    Science.gov (United States)

    Schehl, M

    1997-01-01

    A study conducted by AVSC International between 1992 and 1995 found that couples around the world go through a highly similar decision-making process when they choose vasectomy as their family planning methods. Study findings are based upon in-depth, qualitative interviews with couples using vasectomy in Bangladesh, Mexico, Kenya, and Rwanda, where the prevalence of vasectomy is relatively low, and Sri Lanka and the US, where it is relatively high. 218 separate interviews were conducted with male and female partners. Concerns about the woman's health were cited by respondents in each country as reasons to cease childbearing and to opt for vasectomy as the means to achieving that end. Also, almost all respondents mentioned varying degrees of financial hardship as contributing to their decision to end childbearing. These findings highlight the concept of partnership in relationships and family planning decision-making, and demonstrate the importance of going beyond traditional stereotypes about gender roles in decision-making. Social influences and the potential risks of using other forms of contraception also contributed to the choice of using vasectomy. The decision-making process and lessons learned are discussed.

  17. Choosing the Right Tool

    Science.gov (United States)

    Boote, Stacy K.

    2016-01-01

    Students' success with fourth-grade content standards builds on mathematical knowledge learned in third grade and creates a conceptual foundation for division standards in subsequent grades that focus on the division algorithm. The division standards in fourth and fifth grade are similar; but in fourth grade, division problem divisors are only one…

  18. Choosing a Motion Detector.

    Science.gov (United States)

    Ballard, David M.

    1990-01-01

    Examines the characteristics of three types of motion detectors: Doppler radar, infrared, and ultrasonic wave, and how they are used on school buses to prevent students from being killed by their own school bus. Other safety devices cited are bus crossing arms and a camera monitor system. (MLF)

  19. Testing Trends: Considerations for Choosing and Using Assessments

    Science.gov (United States)

    Woods, Julie Rowland

    2015-01-01

    While federal law requires students to be tested in math, English-language arts and science in particular grades, states are still struggling to mount the resources and expertise necessary to fully implement college and career readiness standards, let alone new assessments aligned to these higher standards. New assessments are not only more…

  20. "Who am I supposed to let down?" The caring work and emotional labor of vocational teachers working with potential drop-out students

    DEFF Research Database (Denmark)

    Lippke, Lena

    social sciences I will present a preliminary analysis of the notion of care as socially situated within the vocational educational system. As a part of the analysis I will conceptualize how teachers try to manage both their own emotions and the emotional well-being of the students. Based upon the work......” and sensing their students. In the interviews the teachers often use the word “care” and describe emotional dilemmas as an everyday experience working with the students. However the emotional aspect of vocational educational teachers´ work is largely under examined. Inspired by the emotional turn within...... of Hochschild (1983, 2003) I will show how emotional labor is a central component of vocational educational teachers´ work and discuss the implications of an institutionalization and professionalization of human care....

  1. "Who am I supposed to let down?": The caring work and emotional practices of vocational educational training teachers working with potential drop-out students

    DEFF Research Database (Denmark)

    Lippke, Lena

    2012-01-01

    initiatives and as a result, most colleges have established extended basic courses aimed at students with personal, social and/or academic difficulties. This paper aims to explore the emotional aspects of vocational educational teachers’ work and present a preliminary analysis of the notion of care....... Findings – The paper provides empirical insights into the emotional practices and the management of emotions related to prevention of dropout within an educational setting. It shows how emotional practices can provide both teachers and students with positive identities and make out a productive force...... that prevents students from dropping out. However the management of emotions also involves a range of dilemmas and ambivalences revealing the difficult limitations related to an institutionalization and professionalization of human care. Research limitations/implications – Because of the chosen research design...

  2. How to investigate the goal orientations of students in competence-based pre-vocational secondary education: choosing the right instrument.

    NARCIS (Netherlands)

    Dr. M. Koopman; prof dr Douwe Beijaard; Dr P.J. Teune

    2008-01-01

    This study explores the psychometric properties of three instruments: a semi-structured interview, a questionnaire and a sorting task. The central question is which instrument is most suitable to investigate the goal orientations of students in competence-based Pre-Vocational Secondary Education.

  3. Online or face-to-face instruction? A qualitative study on the electrocardiogram course at the University of Ulm to examine why students choose a particular format.

    Science.gov (United States)

    Keis, Oliver; Grab, Claudia; Schneider, Achim; Öchsner, Wolfgang

    2017-11-09

    Since the introduction of the e-learning electrocardiogram (ECG) course 'ECG Online' into the curriculum at the University of Ulm, a small but relatively constant number of students have decided not to participate in the online course but to attend the face-to-face course, although the content of both courses is identical. The present study examined why students prefer one format or the other. In a qualitative research approach, ten medical students were questioned in a guided interview. At the time of the survey the interviewees were enrolled in the 7th to 10th semesters. Among the respondents, 2 had participated only in the face-to-face ECG course, 4 only in the online version and 4 in both the face-to-face and the online course. Interestingly, the very factors associated with e-learning - and always praised as advantages of it - are viewed critically by the students. Thus, although the 24-h access to learning content was consistently evaluated positively, the unlimited availability (lack of expiry date) was not seen as conducive to learning. The lack of fixed time constraints and the attendant lack of pressure were important reasons why some of the students had discontinued the online course prematurely. A similar distinction was seen in the flexibility of location for e-learning, because the very obligation to be physically present on a particular day at a fixed time led to a higher degree of commitment to courses and a willingness to actually attend the course until the end. In addition, if the content has a high degree of perceived professional relevance face-to-face courses are preferred because they offer the possibility of direct interaction. Even though the small sample size limits the generalisability of the results, our findings indicate that when developing online courses students' needs could be better met if measures were included to strengthen extrinsic and intrinsic motivation and formats were favoured that enable students to have a minimum level

  4. Let's Start the Music.

    Science.gov (United States)

    Ivankovic, Patricia; Gilpatrick, Ingrid

    1994-01-01

    A preschool/kindergarten program that serves 18 students with deafness/hearing impairments and 11 hearing children uses music activities to develop speech, audition, language, and movement and to further explore current classroom themes. A deaf teacher models body movements, signs, rhythm, and facial expressions while a hearing teacher models…

  5. Let Them Eat Promises

    Science.gov (United States)

    Duggan, Thomas

    1972-01-01

    Article suggests books and films, as well as newspapers, which senior high-school students who will be voting in 1972 for the first time can study to broaden their understanding of the political parties and the electoral process. School and class activities relevant to the presidential election are also detailed. (PD)

  6. Let's Teach Geometry

    Science.gov (United States)

    Canadas, Maria; Molina, Marta; Gallardo, Sandra; Martinez-Santaolalla, Manuel; Penas, Maria

    2010-01-01

    Making constructions with paper is called "origami" and is considered an art. The objective for many fans of origami is to design new figures never constructed before. From the point of view of mathematics education, origami is an interesting didactic activity. In this article, the authors propose to help High School students understand new…

  7. Let Social Interaction Flourish

    Science.gov (United States)

    Case, Anny Fritzen

    2016-01-01

    The author describes lessons learned--through a high school project that grouped English language learners with native speakers to create a video--about ways to foster respectful, productive interaction among English learners and peers who are native speakers. The potential benefits of students who are just learning English interacting socially…

  8. Online or face-to-face instruction? A qualitative study on the electrocardiogram course at the University of Ulm to examine why students choose a particular format

    Directory of Open Access Journals (Sweden)

    Oliver Keis

    2017-11-01

    Full Text Available Abstract Background Since the introduction of the e-learning electrocardiogram (ECG course ‘ECG Online’ into the curriculum at the University of Ulm, a small but relatively constant number of students have decided not to participate in the online course but to attend the face-to-face course, although the content of both courses is identical. The present study examined why students prefer one format or the other. Methods In a qualitative research approach, ten medical students were questioned in a guided interview. At the time of the survey the interviewees were enrolled in the 7th to 10th semesters. Among the respondents, 2 had participated only in the face-to-face ECG course, 4 only in the online version and 4 in both the face-to-face and the online course. Results Interestingly, the very factors associated with e-learning – and always praised as advantages of it – are viewed critically by the students. Thus, although the 24-h access to learning content was consistently evaluated positively, the unlimited availability (lack of expiry date was not seen as conducive to learning. The lack of fixed time constraints and the attendant lack of pressure were important reasons why some of the students had discontinued the online course prematurely. A similar distinction was seen in the flexibility of location for e-learning, because the very obligation to be physically present on a particular day at a fixed time led to a higher degree of commitment to courses and a willingness to actually attend the course until the end. In addition, if the content has a high degree of perceived professional relevance face-to-face courses are preferred because they offer the possibility of direct interaction. Conclusions Even though the small sample size limits the generalisability of the results, our findings indicate that when developing online courses students’ needs could be better met if measures were included to strengthen extrinsic and intrinsic

  9. Choosing to Participate: Revised Edition

    Science.gov (United States)

    Goldstein, Phyllis; Strom, Adam

    2009-01-01

    "Choosing to Participate" focuses on civic choices--the decisions people make about themselves and others in their community, nation, and world. The choices people make, both large and small, may not seem important at the time, but little by little they shape them as individuals and responsible global citizens. "Choosing to…

  10. Let G be a group

    DEFF Research Database (Denmark)

    Lützen, Jesper

    2015-01-01

    I moderne formalistisk matematik er ontologi blevet erstattet med spørgsmålet om konsistens af et aksiomatisk system. I artiklen gøres der rede for hvordan denne opfattelse er blevet til og denne historie opfattes i sig selv som en slags erstatning for ontologi......I moderne formalistisk matematik er ontologi blevet erstattet med spørgsmålet om konsistens af et aksiomatisk system. I artiklen gøres der rede for hvordan denne opfattelse er blevet til og denne historie opfattes i sig selv som en slags erstatning for ontologi...

  11. Choose your doctorate.

    Science.gov (United States)

    Jolley, Jeremy

    2007-02-01

    The development of education options for nurses has been inexorable and it is increasingly the case that senior nurses are considering a doctorate as the logical next step in their educational career. Such individuals need to make important decisions as to whether they should embark on a taught doctorate, professional doctorate or a traditional PhD. Each of these options will necessitate a considerable investment in time and money as well as the sacrifice of quality time and spare time over a significant number of years. A doctorate is not for everyone. Those still reading this text may be asking 'could this possibly be for me'? This paper will try to help the reader decide which if any option to take. It is suggested that nurses will now turn to the doctoral degree as their next adventure in academic study. It is argued that this development is not being controlled by management forces and indeed cannot be controlled by them. This last is chiefly because the move towards doctoral education is led by individuals who choose to study for a doctorate simply because they can. The paper considers what choices are available to nurses who wish to pursue a doctoral programme of study. In particular, this paper considers what new developments in doctoral courses are becoming available and what advantage there may be in studying for one of the newer professional doctorates rather than a traditional PhD. The material here is the result of a review of the literature on recent developments in doctoral education for nurses. The existing provision by UK and other universities was also reviewed, the data being collected by an informal review of universities' advertising material. It is inevitable that some nurses who are already qualified to degree and masters degree will take advantage of the doctoral degree opportunities which now newly present themselves. For nurses in practice, the advantages of the professional doctorate is that it is more structured, enables more peer and

  12. Let us fish4tomorrow

    OpenAIRE

    J.D., Farrugia

    2015-01-01

    All over the world, governments and stakeholders are trying to cope with overfishing. Overfishing is when too much fish is caught which leads to an overall degradation of the marine ecosystem. It is the non-sustainable use of ocean resources. http://www.um.edu.mt/think/let-us-fish4tomorrow/

  13. LET-effects in DNA

    International Nuclear Information System (INIS)

    Kraft, G.; Taucher-Scholz, G.; Heilmann, J.

    1994-11-01

    In this contribution, an introductory view on the physical properties of ions is given and the cellular response to high LET radiation is summarized. Then the measurements of strand break induction of DNA in solution and in intracellular DNA are reported and compared to cell survival. The possibility of changes in the quality of the lesions is discussed and finally the present status of model calculations in comparison to the experiments is given. (orig./HSI)

  14. Educational Vouchers: Freedom to Choose?

    OpenAIRE

    Reel, Jordan; Block, Walter E.

    2013-01-01

    Milton Friedman is famous for his book title: “Free to Choose.” He also favors educational vouchers, which denies the freedom to choose to people who do not wish to subsidize the education of other people’s children. Thus, he is guilty of a logical contradiction. Why is it important to assess whether Friedman’s views on educational vouchers are logically consistent with his widespread reputation as an advocate of free enterprise, and, thus, freedom to chose? It is important to assess all figu...

  15. Ionization chambers for LET determination

    DEFF Research Database (Denmark)

    Kaiser, Franz-Joachim; Bassler, Niels; Tölli, Heikki

    2010-01-01

    resolution and high sensitivity are necessary. For exact dosimetry which is done using ionization chambers (ICs), the recombination taking place in the IC has to be known. Up to now, recombination is corrected phenomenologically and more practical approaches are currently used. Nevertheless, Jaff´e's theory...... of columnar recombination was designed to model the detector efficiency of an ionization chamber. Here, we have shown that despite the approximations and simplification made, the theory is correct for the LETs typically found in clinical radiotherapy employing particles from protons to carbon ions...

  16. High-LET radiation carcinogenesis

    International Nuclear Information System (INIS)

    Fry, R.J.M.; Powers-Risius, P.; Alpen, E.L.; Ainsworth, E.J.

    1985-01-01

    The dose-response curves for the induction of tumors by high-LET radiation are complex and are insufficiently understood. There is no model or formulation to describe the dose-response relationship over a range 0 to 100 rad. Evidence suggests that at doses below 20 rad the response is linear, at least for life shortening and some tumor systems. Thus, limiting values of RBEs for the induction of cancer in various tissues can be determined, but it will require sufficient data obtained at low single doses or with small fractions. The results obtained from experiments with heavy ions indicate an initial linear response with a plateauing of the curve at a tumor incidence level that is dependent on the type of tissue. The RBE values for the heavy ions using 60 Co gamma rays as the reference radiation increase with the estimated LET from 4 for 4 H to about 27 for 56 Fe, 40 Ar. The dose-responses and RBEs for 56 Fe and 40 Ar are similar to those for fission neutrons. These findings suggest the possibility that the effectiveness for tumor induction reaches a maximum. 26 refs., 4 figs., 2 tabs

  17. Killing, letting die and euthanasia.

    Science.gov (United States)

    Husak, D N

    1979-12-01

    Medical ethicists debate whether or not the moral assessment of cases of euthanasia should depend on whether the patient is 'killed' or 'allowed to die'. The usual presupposition is that a clear distinction between killing and letting die can be drawn so that this substantive question is not begged. I contend that the categorisation of cases of instances of killing rather than as instances of letting die depends in part on a prior moral assessment of the case. Hence is it trivially rather than substantively true that the distinction has moral significance. But even if a morally neutral (ie non-question begging) distinction could be drawn, its application to the euthanasia controversy is problematic. I illustrate the difficulties of employing this distinction to reach moral conclusions by critically discussing Philippa Foot's recent treatment of euthanasia. I conclude that even if an act of euthanasia is an instance of killing, and there exists a prima facie moral duty not to kill, and no more stringent duty overrides this duty, one still cannot determine such an act to be morally impermissible.

  18. Killing, letting die and euthanasia.

    Science.gov (United States)

    Husak, D N

    1979-01-01

    Medical ethicists debate whether or not the moral assessment of cases of euthanasia should depend on whether the patient is 'killed' or 'allowed to die'. The usual presupposition is that a clear distinction between killing and letting die can be drawn so that this substantive question is not begged. I contend that the categorisation of cases of instances of killing rather than as instances of letting die depends in part on a prior moral assessment of the case. Hence is it trivially rather than substantively true that the distinction has moral significance. But even if a morally neutral (ie non-question begging) distinction could be drawn, its application to the euthanasia controversy is problematic. I illustrate the difficulties of employing this distinction to reach moral conclusions by critically discussing Philippa Foot's recent treatment of euthanasia. I conclude that even if an act of euthanasia is an instance of killing, and there exists a prima facie moral duty not to kill, and no more stringent duty overrides this duty, one still cannot determine such an act to be morally impermissible. PMID:541821

  19. Ataxia telangiectasia: LET dependence of cellular inactivation

    International Nuclear Information System (INIS)

    Blakely, E.A.; Tobias, C.A.

    1984-01-01

    Human Ataxia telangiectasia cells (AT 2SF line) have been irradiated in vitro under aerobic and hypoxic conditions with heavy-ion beams accelerated at the Berkeley Bevalac as a part of a study to characterize the radiation responses of genetically sensitive and resistant cell lines to high LET radiations. Results from track-segment exposures to neon, silicon, argon and iron ion beams accelerated to initial energies of from 225 to 670 MeV/amu provided an LET range between 30 to 1,000 KeV/μm. The data indicate: (1) The sensitivity of AT cells increases with increasing LET, similar to resistant human lines (e.g., T-1 cells). However, due to efficient repair, T-1 cells are more resistant than AT cells at LET values below 200 keV/μm; (2) Maximum cell kill occurs for both lines at 100-200 keV/μm; at higher LET the sensitivity of the two lines approach each other; (3) There is only small variation in the sensitivity of AT cells to particles of various atomic numbers at the same LET; differences are more pronounced in the LET domain between 50 and 200 keV/μm; and (4) AT cells have slightly lower OER values than T-1 cells in the range of LET studied below 200 keV/μm

  20. Identification of let-7-regulated oncofetal genes

    DEFF Research Database (Denmark)

    Boyerinas, Benjamin; Park, Sun-Mi; Shomron, Noam

    2008-01-01

    -regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, suggesting that let-7-regulated oncofetal genes (LOG) may become reexpressed in cancer cells. Using comparative bioinformatics, we have identified 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP. IMP-1...

  1. Calculated LET-Spectrum of Antiprotons

    DEFF Research Database (Denmark)

    Bassler, Niels

    -LET components resulting from the annihilation. Though, the calculations of dose-averaged LET in the entry region may suggest that the RBE of antiprotons in the plateau region could significantly differ from unity. Materials and Methods Monte Carlo simulations using FLUKA were performed for calculating...

  2. Choosing a Career in Psychiatry

    Science.gov (United States)

    ... Registry Residents & Medical Students Residents Medical Students Patients & Families Mental Health Disorders/Substance Use Find a Psychiatrist Addiction and Substance Use Disorders ADHD Anxiety Disorders Autism Spectrum Disorder Bipolar Disorders Depression Eating Disorders Obsessive-Compulsive ...

  3. Choosing final-year placement

    African Journals Online (AJOL)

    class consultants'. 2. Financial implications. The students considered financial constraints on themselves and their parents. Students living at home felt that it would be expensive to relocate and cheaper to remain at the urban campus. The.

  4. Ombud's corner: About letting go…

    CERN Multimedia

    Sudeshna Datta-Cockerill

    2015-01-01

    New year, old problems? The best way to start 2015 is by not carrying over any frustration from 2014. Instead, let it go and move forward.   As I blew out the candle to celebrate my first anniversary of my position as the CERN Ombud, I found myself reflecting back over the past year, wondering what I could share with you, and the following recurring situation came to mind… Often, people come to the Ombud’s office either because they feel mistreated or because they consider themselves to be facing an unfair situation. When this happens, we work through the problems together and identify different options by which to tackle the situation.  Sometimes they ask to be coached through the way in which to go back and deal with the issues themselves; at other times they prefer to address the issue with the other person, in the presence of the Ombud, and request mediation. In both cases, the objective is the same: to ensure that both points of view are understood...

  5. Choosing the Right Systems Integration

    Directory of Open Access Journals (Sweden)

    Péči Matúš

    2014-12-01

    Full Text Available The paper examines systems integration and its main levels at higher levels of control. At present, the systems integration is one of the main aspects participating in the consolidation processes and financial flows of a company. Systems Integration is a complicated emotionconsuming process and it is often a problem to choose the right approach and level of integration. The research focused on four levels of integration, while each of them is characterized by specific conditions. At each level, there is a summary of recommendations and practical experience. The paper also discusses systems integration between the information and MES levels. The main part includes user-level integration where we describe an example of such integration. Finally, we list recommendations and also possible predictions of the systems integration as one of the important factors in the future.

  6. Educational Vouchers: Freedom to Choose?

    Directory of Open Access Journals (Sweden)

    Jordan Reel

    2013-12-01

    Full Text Available Milton Friedman is famous for his book title: “Free to Choose.” He also favors educational vouchers, which denies the freedom to choose to people who do not wish to subsidize the education of other people’s children. Thus, he is guilty of a logical contradiction. Why is it important to assess whether Friedman’s views on educational vouchers are logically consistent with his widespread reputation as an advocate of free enterprise, and, thus, freedom to chose? It is important to assess all figures in political economy, and indeed all of scholarship, for logical consistency. It is particularly important to do so in the present case, given the prestige in certain quarters accorded to this Nobel prize-winning economist. We argue in this paper that Friedman’s reputation for logical consistency, and adherence to the philosophy of laissez faire capitalism, are both overblown. Our solution to this challenge is to completely privatize education. Friedman does not advocate that vouchers be utilized for food, clothing or shelter; we see no relevant difference in the case of education. What is the justification of the undertaken topic? This topic is important because education of the next generation is crucial for the upkeep and improvement of society. What is the aim of the present study? It is to demonstrate that the solution offered by M. Friedman and R. Friedman (1990 is highly problematic. What is the methodology used in the study? We quote from this author, and criticize his analysis. What are our main results and conclusions/recommendations? We conclude that the last best hope for the educational industry is laissez faire capitalism, not the mixed economy recommended by Friedman.

  7. Let's do comprehension 5-6

    CERN Document Server

    Brodie, Andrew

    2015-01-01

    Let's Do Comprehension is a brand new series of six titles in the popular 'Let's Do' range. Each book contains a rich variety of stimulating reading passages, accompanied by questions of varying difficulty. Designed to be used at home, each book includes tips and clues from Alice the Alligator as well as extra challenges in Brodie's Brain Boosters. There is a clear answer section for reference by parents and children, together with bright, colourful reward stickers.

  8. Let's do comprehension 8-9

    CERN Document Server

    Brodie, Andrew

    2015-01-01

    Let's Do Comprehension is a brand new series of six titles in the popular 'Let's Do' range. Each book contains a rich variety of stimulating reading passages, accompanied by questions of varying difficulty. Designed to be used at home, each book includes tips and clues from Alice the Alligator as well as extra challenges in Brodie's Brain Boosters. There is a clear answer section for reference by parents and children, together with bright, colourful reward stickers.

  9. Owning, letting and demanding second homes

    DEFF Research Database (Denmark)

    Bloze, Gintautas; Skak, Morten

    register data and presents estimations of the probability of owning a second home, the decision to let the second home and the number of let weeks per year. Also income elasticities for primary and second housing demand are estimated. We find a conventional monotonic increase in demand elasticities...... for primary housing demand for non-owners of second homes; however, owners of second homes have the highest income elasticity in the middle income group....

  10. Special photographic emulsions for high LET dosimetry

    International Nuclear Information System (INIS)

    Katz, R.

    1978-12-01

    The purpose of these investigations into photographic emulsion dosimetry is to attempt to use the photographic emulsion to mimic the response of human tissues to high LET radiations. The program therefore requires that a systematic understanding of the response of mammalian cells to ionizing radiations be achieved. We have been concerned with differences in RBE and in radiation response to both high and LET radiations, and in the interrelationship between observations with these different radiations

  11. Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation

    International Nuclear Information System (INIS)

    Supiot, Stephane; Thillays, Francois; Rio, Emmanuel; Gouard, Sebastien; Morgenstern, Alfred; Bruchertseifer, Frank; Mahe, Marc-Andre; Chatal, Jean-Francois; Davodeau, Francois; Cherel, Michel

    2007-01-01

    The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT 213 Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET

  12. The concept of average LET values determination

    International Nuclear Information System (INIS)

    Makarewicz, M.

    1981-01-01

    The concept of average LET (linear energy transfer) values determination, i.e. ordinary moments of LET in absorbed dose distribution vs. LET of ionizing radiation of any kind and any spectrum (even the unknown ones) has been presented. The method is based on measurement of ionization current with several values of voltage supplying an ionization chamber operating in conditions of columnar recombination of ions or ion recombination in clusters while the chamber is placed in the radiation field at the point of interest. By fitting a suitable algebraic expression to the measured current values one can obtain coefficients of the expression which can be interpreted as values of LET moments. One of the advantages of the method is its experimental and computational simplicity. It has been shown that for numerical estimation of certain effects dependent on LET of radiation it is not necessary to know the dose distribution but only a number of parameters of the distribution, i.e. the LET moments. (author)

  13. Human Cloning: Let's Discuss It.

    Science.gov (United States)

    Taras, Loretta; Stavroulakis, Anthea M.; Ortiz, Mary T.

    1999-01-01

    Describes experiences with holding discussions on cloning at a variety of levels in undergraduate biology courses. Discusses teaching methods used and student reactions to the discussions. Contains 12 references. (WRM)

  14. Let's Make Metric Ice Cream

    Science.gov (United States)

    Zimmerman, Marianna

    1975-01-01

    Describes a classroom activity which involved sixth grade students in a learning situation including making ice cream, safety procedures in a science laboratory, calibrating a thermometer, using metric units of volume and mass. (EB)

  15. 77 FR 16566 - Submission for OMB Review, Comment Request, Proposed Collection: Let's Move Museums, Let's Move...

    Science.gov (United States)

    2012-03-21

    ..., Proposed Collection: Let's Move Museums, Let's Move Gardens AGENCY: Institute of Museum and Library..., comment request. SUMMARY: The Institute of Museum and Library Services announces that the following... functions of the agency, including whether the information will have practical utility; Evaluate the...

  16. Let's do science with children

    Science.gov (United States)

    Paolini, Mara

    2013-04-01

    The school where I worked in 2011,was for primary school teachers-to-be. Classes were formed by a high number of students with a handicapped student in each class. The school was attended mainly by girls with low self-esteem and difficulties in fulfilling their homework. Moreover secondary school students often find science far from their world and rather boring. So helping them understand the relationship between science and everyday life, between chemistry and society was my main objective . Simple / elementary experiments were chosen : if presented and carried out with scientific method, they can prove very useful in the development of specific abilities, from simple observation to the more complex and vital ability to grasp cause and effect relation. I think that the direct observation of facts and phenomena is the foundation to stimulate the process of learning and abstracting experiments: A. The pressure as a force, the behavior of the hot and cold water. 1. the implosion of the can 2. the candle 3. the balloon and the bottle 4. the egg in the bottle Monitoring and evaluation The direct observation of students during operations and final written reports were the ways which was evaluated the project. Results of the project carried out: The students were able to use scientific language correctly, to explain the phenomenon to primary school children using their own ideas. they also devised a table where to list the experiments carried out

  17. Let's Burn Them All: A Librarian's View

    Science.gov (United States)

    Werner, Roye

    2014-01-01

    In this rejoinder to "Let's Burn Them All," a librarian supports the author's case for eliminating textbooks in the teaching of management and organizational behavior. A move away from textbooks would free libraries from worrying about whether and to what extent to provide expensive textbook access to students, a long-standing…

  18. Stakeholders' Opinions on "Let the Schools Become Life" Project in Scope of Lifelong Learning Activities

    Science.gov (United States)

    Karatas, Süleyman

    2015-01-01

    The objective of this study is to find out the opinions of school administrators, teachers, staff, benefiting students and parents and other stakeholders of "Let the Schools Become Life" project being carried out in order to reveal the effectiveness and efficiency of the project. Data in this qualitative research was gathered by…

  19. Tri-P-LETS: Changing the Face of High School Computer Science

    Science.gov (United States)

    Sherrell, Linda; Malasri, Kriangsiri; Mills, David; Thomas, Allen; Greer, James

    2012-01-01

    From 2004-2007, the University of Memphis carried out the NSF-funded Tri-P-LETS (Three P Learning Environment for Teachers and Students) project to improve local high-school computer science curricula. The project reached a total of 58 classrooms in eleven high schools emphasizing problem solving skills, programming concepts as opposed to syntax,…

  20. Choosing nuclear engineering: A survey of nuclear engineering undergraduates

    International Nuclear Information System (INIS)

    Shillenn, J.K.; Klevans, E.H.

    1988-01-01

    Maintaining a reliable pool of qualified nuclear engineering graduates depends on the ability of nuclear engineering undergraduate programs to recruit students. With the prospect of declining enrollments in nuclear engineering it is important for nuclear engineering programs to know what factors influence students to choose nuclear engineering as an undergraduate major and why they choose a particular undergraduate program. This type of information can be very important to nuclear engineering programs that develop recruiting strategies. To provide some insight into this area, a questionnaire was designed and given to undergraduate nuclear engineering students at Pennsylvania State University. The purpose of the survey was to provide information on the reasons that students picked nuclear engineering as a career and chose to attend Penn State. The questionnaire was given to 27 students in their junior year during the spring semester of 1987 and again to 35 junior students during the spring semester of 1988. There was little difference except as noted between the two groups on their responses to the questionnaire. A partial listing of the survey results is provided

  1. Are you a developer? Let's talk!

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    Many of us have to create software as part of our work, if you do probably you asked yourself some of the following: How other people at CERN develop? What technologies have they used? What worked and what didn't for them? Am I reinventing the wheel? What CERN services can make my life easier? What other services I miss that would be useful to have? How can I integrate my system with XXYY at CERN? Unfortunately there is little communication between us and we need to fix that, let's find initiatives to improve and share experiences between software engineers... let's talk!

  2. Women Physicians: Choosing a Career in Academic Medicine

    Science.gov (United States)

    Borges, Nicole J.; Navarro, Anita M.; Grover, Amelia C.

    2011-01-01

    Purpose Despite recent efforts to understand the complex process of physician career development, the medical education community has a poor understanding of why, how, and when women physicians embark on a career in academic medicine. Method In 2010, the authors phone-interviewed women physicians in academic medicine regarding why, how, and when they chose an academic medicine career. Project investigators first individually and then collectively analyzed transcripts to identify themes in the data. Results Through analyzing the transcripts of the 53 interviews, the investigators identified five themes related to why women choose careers in academic medicine: fit, aspects of the academic health center environment, people, exposure, and clincial medicine. They identified five themes related to how women make the decision to enter academic medicine: change in specialty, dissatisfaction with former career, emotionality, parental influence, and decision-making styles. The authors also identified four themes regarding when women decide to enter academic medicine: as a practicing phyisican, fellow, resident, or medical student. Conclusions Choosing a career in academic medicine is greatly influenced by the environment in which one trains and by people—be they faculty, mentors, role models, or family. An interest in teaching is a primary reason women choose a career in academic medicine. Many women physicians entering acadmic medicine chose this after or during fellowship, which is when they became more aware of academic medicine as a possible career. For many women, choosing academic medicine was not necessarily an active, planned decision; rather it was serendipitous or circumstantial. PMID:22104052

  3. Oxygen tension in transplanted mouse osteosarcomas during fractionated high-LET- and low-LET radiotherapy - predictive aspects for choosing beam quality?

    International Nuclear Information System (INIS)

    Auberger, T.; Thuerriegel, B.; Freude, T.; Weissfloch, L.; Kneschaurek, P.; Molls, M.; Senekowitsch-Schmidtke, R.; Wagner, F.M.

    1999-01-01

    Murine OTS64 - osteosarcomas were tranplanted in 102 balb-C mice and irradiated by 36 Gy of photons in fractions of 3 Gy five times a week (group P-36/3) or by 12 Gy of reactor fission neutrons in fractions of 2 Gy two times a week (group N-12/2). Irradiations started at a tumor volume of 500 to 600 mm 3 . A third group received no radiotherapy, but all investigations (group CG). Tumor volume and tumor oxygenation were measured once a week under therapy and during three weeks after therapy. For in vivo-evaluation of oxygen status a computerized polarographic needle electrode system (KIMOC pO 2 histograph, Eppendorf) was used. The median pO 2 and the hypoxic fraction (pO 2 values 2 decreased from 20 mm to 8 mm Hg and the hypoxic fraction increased from 7% to 31%. After fractionated photon therapy a growth delay of three weeks was observed. Six weeks after beginning of the irradiation the median tumor volume had been doubled again. After fission neutron therapy growth delay continued until the end of the follow-up period. In both of the irradiated groups a significant decrease of median pO 2 values and an increase of the hypoxic fraction were observed under radiotherapy. Hypoxia was more intensive after neutrons with a decrease of the median pO 2 from 20 mm Hg to 1 mm Hg vs. 10 mm Hg after photon therapy and with an increase of the hypoxic fraction from 7% to 78% vs. 36% respectively. Two weeks after the end of therapy the median pO 2 and the hypoxic fraction of both treated groups reached the levels prior to irradiation indicating a complete reoxygenation. (orig.)

  4. The Lin28/let-7 Axis Regulates Glucose Metabolism

    NARCIS (Netherlands)

    Zhu, Hao; Shyh-Chang, Ng; Segre, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G.; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

    2011-01-01

    The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating-metabolism. When overexpressed in mice, both

  5. Letting die: A moral defence | Adenugba | Sophia: An African ...

    African Journals Online (AJOL)

    This paper draws a distinction between letting die and active euthanasia. It argues that there is a moral difference between letting die and active euthanasia which strictly intends to cause death. The difference between letting die and active euthanasia lies in intention though intention in both cases can be said to be ...

  6. Further tests of the Scalar Expectancy Theory (SET) and the Learning-to-Time (LeT) model in a temporal bisection task.

    Science.gov (United States)

    Machado, Armando; Arantes, Joana

    2006-06-01

    To contrast two models of timing, Scalar Expectancy Theory (SET) and Learning to Time (LeT), pigeons were exposed to a double temporal bisection procedure. On half of the trials, they learned to choose a red key after a 1s signal and a green key after a 4s signal; on the other half of the trials, they learned to choose a blue key after a 4-s signal and a yellow key after a 16-s signal. This was Phase A of an ABA design. On Phase B, the pigeons were divided into two groups and exposed to a new bisection task in which the signals ranged from 1 to 16s and the choice keys were blue and green. One group was reinforced for choosing blue after 1-s signals and green after 16-s signals and the other group was reinforced for the opposite mapping (green after 1-s signals and blue after 16-s signals). Whereas SET predicted no differences between the groups, LeT predicted that the former group would learn the new discrimination faster than the latter group. The results were consistent with LeT. Finally, the pigeons returned to Phase A. Only LeT made specific predictions regarding the reacquisition of the four temporal discriminations. These predictions were only partly consistent with the results.

  7. Guide to Choosing Stroke Rehabilitation Services

    Science.gov (United States)

    National Stroke Association’s Guide to Choosing Stroke Rehabilitation Services Rehabilitation, often referred to as rehab, is an important part of stroke recovery. Through rehab, you:  Re-learn basic skills such ...

  8. Skilled nursing and rehabilitation facilities - choosing

    Science.gov (United States)

    ... gov/ency/patientinstructions/000436.htm Choosing a skilled nursing and rehabilitation facility To use the sharing features ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  9. How to choose a health plan

    Science.gov (United States)

    ... patientinstructions/000861.htm How to choose a health plan To use the sharing features on this page, ... paperwork for tax purposes. How to Compare Health Plans Employers and government sites, such as the Marketplace , ...

  10. Choosing a Geothermal as an HVAC System.

    Science.gov (United States)

    Lensenbigler, John D.

    2002-01-01

    Describes the process of selecting and installing geothermal water source heat pumps for new residence halls at Johnson Bible College in Knoxville, Tennessee, including choosing the type of geothermal design, contractors, and interior equipment, and cost and payback. (EV)

  11. Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET radiations

    Data.gov (United States)

    National Aeronautics and Space Administration — Ionizing radiations are categorized by linear energy transfer (LET) into low-LET and high-LET. High-LET is considered to have a higher relative biological...

  12. High-LET charged particle radiotherapy

    International Nuclear Information System (INIS)

    Castro, J.R.; California Univ., San Francisco, CA

    1991-07-01

    The Department of Radiation Oncology at UCSF Medical Center and the Radiation Oncology Department at UC Lawrence Berkeley Laboratory have been evaluating the use of high LET charged particle radiotherapy in a Phase 1--2 research trial ongoing since 1979. In this clinical trail, 239 patients have received at least 10 Gy (physical) minimum tumor dose with neon ions, meaning that at least one-half of their total treatment was given with high-LET charged particle therapy. Ninety-one patients received all of their therapy with neon ions. Of the 239 patients irradiated, target sites included lesions in the skin, subcutaneous tissues, head and neck such as paranasal sinuses, nasopharynx and salivary glands (major and minor), skull base and juxtaspinal area, GI tract including esophagus, pancreas and biliary tract, prostate, lung, soft tissue and bone. Analysis of these patients has been carried out with a minimum followup period of 2 years

  13. Enabling narrative pedagogy: inviting, waiting, and letting be.

    Science.gov (United States)

    Ironside, Pamela M

    2014-01-01

    This article describes how teachers enable Narrative Pedagogy in their courses by explicating the Concernful Practice Inviting: Waiting and Letting Be. Narrative Pedagogy, a research-based, phenomenological approach to teaching and learning, extends conventional pedagogies and offers nursing faculty an alternative way of transforming their schools and courses. Using hermeneutic phenomenology, interview data collected over a 10-year period were analyzed by coding practical examples of teachers' efforts to enact Narrative Pedagogy. When Narrative Pedagogy is enacted, teachers and students focus on thinking and learning together about nursing phenomena and seek new understandings about how they may provide care in the myriad situations they encounter. Although the Concernful Practices co-occur, explicating inviting experiences can assist new teachers, and those seeking to extend their pedagogical literacy, by providing new understandings of how Narrative Pedagogy can be enacted.

  14. Design criteria for a hemispherical detector for LET measurements

    International Nuclear Information System (INIS)

    Schell, M.C.; DeLuca, P.M. Jr.; Pearson, D.W.; Attix, F.H.

    1980-01-01

    A detector for the direct measurement of the Linear Energy Transfer (LET) in cylindrical geometry was developed by Brandan and DeLuca. The detector successfully measured the LET of protons and a fraction of the heavy charged particles generated in cylindrical A150 plastic and graphite walls by 14.8 MeV neutrons. In this report, we present design tests for the hemispherical LET detector which will measure the LET of charged particles in spherical geometry and allow comparison with calculated LET spectra. The hemispherical LET detector will also provide a data base for radiobiological predictions with the Track Structure Model by Katz. A comparison of predictions of radiobiological effects by the Theory of Dual Radiation Action and the Track Structure Model by Edwards and the authors indicate that the Track Structure Model predicts cell survival as a function of dose more accurately and hence an additional motivation for the present construction of the hemispherical LET detector

  15. Why are junior doctors deterred from choosing a surgical career?

    Science.gov (United States)

    Rogers, Mary E; Creed, Peter A; Searle, Judy

    2012-05-01

    To identify the reasons why interns would not choose a surgical career. This qualitative study used semi-structured telephone interviews to explore the future career choices of 41 junior doctors (14 men, 27 women). Doctors were asked to identify specialties they would not take up, and state why this was the case. Thirty (73.2%) of the 41 interns nominated surgery as a specialty they would not choose. Themes relating to reasons for not wanting to pursue a surgical career included the lifestyle associated with surgery (66.7%), the culture within the surgical work environment (53.3%), the lack of interest in performing surgical work (36.7%), and the training requirements associated with surgery (33.3%). Both sexes had similar reasons for not wanting to choose a surgical career; but additionally, women referred to the male domination of surgery, and the difficulty and inflexibility of the training program as deterrents. Efforts are needed to promote interest in surgery as a career especially for women, to improve the surgical work environment so that medical students and junior doctors have exposure to positive role models and surgical placements, and to provide a more flexible approach to surgical training.

  16. Cloud Computing and the Power to Choose

    Science.gov (United States)

    Bristow, Rob; Dodds, Ted; Northam, Richard; Plugge, Leo

    2010-01-01

    Some of the most significant changes in information technology are those that have given the individual user greater power to choose. The first of these changes was the development of the personal computer. The PC liberated the individual user from the limitations of the mainframe and minicomputers and from the rules and regulations of centralized…

  17. Wood preservatives : choosing the right one

    Science.gov (United States)

    Matt Humphries; Stan Lebow; David Moses

    2009-01-01

    If you are having trouble choosing the right wood preservative system for your application, you are not alone. Dozens of products are available, some older types have gone out of use, others may be completely inappropriate for your application. As designers, specifiers and builders, you need to understand key information to be able to navigate through all of these...

  18. A Review: Some biological effects of high LET radiations

    Science.gov (United States)

    Wiley, A., Jr.

    1972-01-01

    There are qualitative and quantitative differences in the biological damage observed after exposure to high LET radiation as compared to that caused by low LET radiations. This review is concerned with these differences, which are ultimately reflected at the biochemical, cellular and even whole animal levels. In general, high LET radiations seem to produce biochemical damage which is more severe and possibly less repairable. Experimental data for those effects are presented in terms of biochemical RBE's with consideration of both early and late manifestations. An LET independent process by which significant biochemical damage may result from protons, neutrons and negative pion mesons is discussed.

  19. RBE-LET relationships of high-LET radiations in drosophila mutations

    International Nuclear Information System (INIS)

    Yoshikawa, Isao; Takatsuji, Toshihiro; Nagano, Masaaki; Takada, Jun; Endo, Satoru; Hoshi, Masaharu

    1999-01-01

    The relative biological effectiveness (RBE) of 252 Cf neutrons and synchrotron-generated high-energy charged particles for mutation induction was evaluated as a function of linear energy transfer (LET), using the loss of heterozygosity for wing-hair mutations and the reversion of the mutant white-ivory eye-color in Drosophila melanogaster. Loss of heterozygosity for wing-hair mutations results predominantly from mitotic crossing over induced in wing anlage cells of larvae, while the reverse mutation of eye-color is due to an intragenic structural change (2.96 kb-DNA excision) in the white locus on the X-chromosome. The measurements were performed in a combined mutation assay system so that induced mutant wing-hair clones as well as revertant eye-color clone can be detected simultaneously in the same individual. Larvae were irradiated at the age of 3 days post oviposition with 252 Cf neutrons, carbon beam or neon beam. For the neutron irradiation, the RBE values for wing-hair mutations were larger than that for eye-color mutation by about 7 fold. The RBE of carbon ions for producing the wing-hair mutations increased with increase in LET. The estimated RBE values were found to be in the range 2 to 6.5 for the wing-hair. For neon beam irradiation, the RBE values for wing-hair mutations peak near 150 keV/μm and decrease with further increase in LET. On the other hand, the RBE values for the induction of the eye-color mutation are nearly unity in 252 Cf neutrons and both ions throughout the LET range irradiated. We discuss the relationships between the initial DNA damage and LET in considering the mechanism of somatic mutation induction. (author)

  20. Analysis Of Economic Motivation When Individuals Choose An Educational Path

    Directory of Open Access Journals (Sweden)

    Viktor Anatolyevich Koksharov

    2015-03-01

    Full Text Available The authors consider the economic motivations when individuals choose an educational path. This line of research is relevant from both, the point of view of science — research of economic behavior of an individual, and the point of view of practice — allows to increase efficiency of investments in a human capital. The authors have developed the economic and mathematical model of choice of optimum educational paths by individuals. The model is realized in the software and approved on real data on more than 5,5 thousand students. For the analysis of the importance of rational economic expectations when an educational path has to be chosen, the paths chosen by students is compared and the educational paths optimum from the point of view of economic rationality are calculated. The analysis of the results has showed that mainly, the choice of educational paths happens according to the economic motivations. On the considered selection, 66 % of prospective students have chosen an optimum path from the point of view of economic preferences. The most significant factor providing development of optimum educational paths is an expectation of higher income upon completion of education — 22 % of all educational paths, and a possibility of cost-cutting of educating or state-subsidized education — 12 %. In our opinion, one of the most important practical results of the research of optimum educational path is the need to consider expectations of students and prospective student when developing a state policy of investment in human capital.

  1. Math Academy: Let's Go to the Mall! Explorations in Combinatorics. Book 5: Supplemental Math Materials for Grades 3-8

    Science.gov (United States)

    Rimbey, Kimberly

    2008-01-01

    Created by teachers for teachers, the Math Academy tools and activities included in this booklet were designed to create hands-on activities and a fun learning environment for the teaching of mathematics to the students. This booklet contains the "Math Academy--Let's Go to the Mall! Explorations in Combinatorics," which teachers can use to enhance…

  2. Chemical protection from high LET radiation

    International Nuclear Information System (INIS)

    Ando, Koichi; Koike, Sachiko; Matsushita, Satoru; Kanai, Tatsuaki; Ohara, Hiroshi

    1992-01-01

    Radioprotection by WR151327 from high LET fast neutrons was investigated and compared with that from low LET radiation. Radiation damage in bone marrow, intestine, skin and leg length were all protected by a pretreatment with 400 mg/kg WR151327. Most prominent protection was observed for bone marrow, which gave a Dose Modifying Factor (DMF) of 2.2 against γ rays. Identical protection was observed between early and late radiation damage. WR151327 protected fast neutrons less efficiently than γ rays; 40% for bone marrow and 80% for skin leg. Pathological findings indicated that hyperplastic change in both dermis and epidermis associated with late skin shrinkage. Laser doppler flow-metry showed a good relationship between reduction of blood flow and late skin shrinkage. Irradiation of skin by heavy particle Carbon-12 indicated that skin shrinkage was modified by unirradiated surrounding normal tissues, which proposed a significant role of 'Volume Effect' in radiation damage. Tumor tissues were less protected by WR151327 than normal tissues. Dependence of radioprotection by WR151327 on tissue oxygen concentration is a probable reason to explain the difference between normal and tumor tissues. (author)

  3. Gene conversion in yeast as a function of linear energy transfer (LET) for low-LET radiation

    International Nuclear Information System (INIS)

    Unrau, P.; Morrison, D.P.; Johnson, J.R.

    1992-05-01

    The relative biological effectiveness (RBE) for low-LET radiation is known to depend on such factors as LET and dose rate. Microdosimetric calculations indicate that the biological target size could also be an important parameter, and calculations predict that the RBE for effects produced by hits in target sizes below about 100 nm should be unity for all low LET radiation. We have measured that RBE for gene conversion in yeast (a small target) for five different low LET photon sources, and the results were consistent with an RBE of unity, which agrees with microdosimetric predictions. 4 refs

  4. Choosing wisely-where is the choice?

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2013-06-01

    Full Text Available No abstract available. Article truncated at 150 words. A little over a year ago an editorial was posted in the Southwest Journal about the Choosing Wisely campaign from the American Board of Internal Medicine and Consumer Reports (1. You may remember that Choosing Wisely announced a list of procedures or treatments that patients should question (2. In the editorial we wondered why pulmonary organizations such as the American Thoracic Society (ATS and the American College of Chest Physicians authored none of the recommendations and offered 10 suggestions. We also openly questioned if the recommendations were intended to improve patient care or reduce costs, and thus improve the profits of third party carriers. We can now report that recommendations were announced at the recent ATS meeting in Philadelphia. Seven recommendations were made for critical care and seven for pulmonary disease. Five from the critical care list and five from the pulmonary list will eventually be chosen for inclusion in …

  5. LET calibration for CR-39 detectors in different oxygen environments

    International Nuclear Information System (INIS)

    Zhou, D.; Semones, E.; Weyland, M.; Benton, E.R.

    2007-01-01

    High LET (linear energy transfer) radiation is the main contributor to the radiation field in low Earth orbit (LEO) in terms of dose equivalent. CR-39 plastic nuclear track detectors (PNTDs) can measure the LET spectrum and charge spectrum for the complicated radiation field in space. Previous research indicated that the sensitivity of CR-39 is different for CR-39 PNTDs working in different oxygen environments. LET calibration for CR-39 detectors in different oxygen environments is needed. Almost all the previous LET calibration work was carried out for CR-39 detectors in good-oxygen condition, LET calibration work for CR-39 in poor-oxygen condition has not been conducted until our work. Systematic LET calibrations were carried out by JSC-SRAG (Space Radiation Analysis Group) for CR-39 detectors working in different oxygen environments and abundant results of LET calibrations were obtained. This paper introduces the method for CR-39 LET calibration, presents and discusses the calibration results and some applications

  6. Learning, Leading and Letting go of Control

    DEFF Research Database (Denmark)

    Jensen, Annie Aarup; Kjær-Rasmussen, Lone Krogh; Iversen, Ann-Merete

    Learning, leading and letting go of control – Learner Led Approaches in Education Annie Aarup Jensen, Lone Krogh Kjær-Rasmussen, Ann-Merete Iversen and Anni Stavnskær Pedersen Abstract The aim of the paper is to introduce a new term in teaching in Higher Education: Learner Led Approaches...... in Education: LED. The sources of inspiration are many as are the experiences we draw from. Problem-based project work (PBL) being one, various classical teacher centered methods, and last but not least a variety of methods aiming towards developing creativity, innovational skills and entrepreneurship. LED...... is inspired by collaboration between professors from Aalborg University, Cornwall College and University College of Northern Denmark. Moravec (2008) claims that educational systems still operate in 1.0 or perhaps 2.0 mode while the surrounding cultures and societies operate in 3.0 mode. The amount...

  7. Liquid ionization chambers for LET determination

    DEFF Research Database (Denmark)

    Kaiser, Franz-Joachim; Bassler, Niels; Tölli, Heikki

    Liquid ionization chambers [1] (LICs) have have been used in the last decades as background dosemeters. Since a few years LICs are also commercially available for dosimetry and are used for measurements of dose distributions where a high spatial distribution is necessary. Also in the last decades...... a differential equation applying several simplifications and approximations leading to discrepancies between theory and experiments [3]. The theory predicts the collection efficiency as a function of the electrical field and was applied for both air filled ionization chambers and liquid filled ionization...... chambers. For liquids the LET can be roughly deduced from the collection efficiency dependency on the electrical field inside a liquid ionization chambers [4] using an extrapolation method. We solved the fundamental differential equation again presented by Jaffe numerically, but now taking into account...

  8. The interaction of radiations of different LET

    International Nuclear Information System (INIS)

    Lam, G.K.Y.

    1987-01-01

    Experimental data for mixed radiation of different LET are analysed using an isobologram approach and are shown to be consistent with the special case of 'zero interaction' in a general formulation of the effect of a combination of agents proposed by Berenbaum. This zero interaction is defined in the same sense as interaction between the lesions produced by the same radiation. This makes analysis and predictions of mixed radiation results particularly straightforward. The zero-interaction formula can be mathematically derived from a simple model of mixed radiation called the lesion additivity model using the assumption that different early lesions produced in the radiation mixture can gradually develop into an indistinguishable intermediate state and hence become additive to produce the same end point. The model is shown to be applicable to irradiation under both hypoxic and oxygenated conditions and hence is extended to the use of hypoxic cell sensitisers. (author)

  9. In vitro RBE-LET dependence for multiple particle types

    DEFF Research Database (Denmark)

    Sørensen, Brita Singers; Overgaard, Jens; Bassler, Niels

    2011-01-01

    Background. In vitro RBE values for various high LET radiation types have been determined for many different cell types. Occasionally it is criticized that RBE for a given endpoint cannot be single-value dependent on LET alone, but also on particle species, due to the different dose deposition...... profiles on microscopic scale. Hence LET is not sufficient as a predictor of RBE, and this is one of the motivations for development of radiobiological models which explicitly depend on the detailed particle energy spectrum of the applied radiation field. The aim of the present study is to summarize...... the available data in the literature regarding the dependency of RBE on LET for different particles. Method. As RBE is highly dependent on cell type and endpoint, we discriminated the RBE-LET relationship for the three investigated cell lines and at the same endpoint (10% survival in colony formation). Data...

  10. High-LET particle exposure of Skylab astronauts

    International Nuclear Information System (INIS)

    Benton, E.V.; Peterson, D.D.; Bailey, J.V.; Parnell, T.

    1977-01-01

    High-LET particle radiation was registered in nuclear track recording plastic dosimeters worn on the wrists of Skylab astronauts and located in a heavily shielded film vault. The mission-average planar flux of high-LET particles with LET >= 100 keV/micron . tissue has been determined to be 2.7 +- 0.6 particles/cm 2 . day . 2π sr and 0.34 +- 0.4 particles/cm 2 . day . 2π sr, respectively, for the nine astronauts and for the film vault. Comparison of results representative of a wide range of shielding depths reveals that the magnitude and slope of the integral LET spectrum of high-LET particles inside spacecraft are proportional to the amount of shielding. (author)

  11. The Comparison of Iranian and Foreign Students’ Motivations to Choose Dentistry Field of Study

    Directory of Open Access Journals (Sweden)

    Abdolreza Gilavand

    2016-06-01

    Full Text Available Background Because of some special and privileged attractions of dentistry discipline, the first choice of volunteers who want to enter university is dentistry. The students usually choose it regardless to their interests and talents. Therefore, this study aimed to investigate Iranian and Foreign student’s motivations to choose dentistry field of study. Materials and Methods We searched international databases such as PubMed, Scopus, EMBASE, Cochrane Library, and Iranian databases such as SID, Magiran, Iranmedex using a searching strategy during 2000 to 2015 years. Database without language restriction, since 2000 sources, with the MeSH term "Choose dentistry field" AND "Students". At first, in the initial search,152 articles were found, and finally, 51 of them which were related to the subject of this research were used. Results In general, the motivation of students to choose field of study in Iranain and Foreign students include the following:: an independent office or job independence, high economic income, appropriate social status,  job attractiveness of dentistry, appropriate job position, individual longing, help others, top rank of student in the university entrance exam, continue to study at specialized PhD in one of dentistry trends, successful marriage nd interest in the field of dentistry. Conclusion It seems that with regard to the high unemployment rate of university graduates in Iran, the most important incentives of applicants who want to enter the dentistry discipline are high income and  particular social prestige at this major. Moreover, high income and independent job situations are the most important factors in Foreign students for choosing this filed of study in the overseas studies.

  12. Empowering Learners to Choose the Difficulty Level of Problems Based on Their Learning Needs

    Directory of Open Access Journals (Sweden)

    Janet Mannheimer Zydney

    2010-08-01

    Full Text Available Research has found that increasing learner control offers several benefits, including increased motivation, attitude, and learning. The goal of the present study was to determine how prior math achievement influences students' selection of the difficulty level of problems within Math Pursuits, a hypermedia learning program. Math Pursuits was designed to help children understand mathematics by discovering how it relates to the world around them. The program presented each learner with an adjustable level of challenge, along with the necessary scaffolding to support success. The researchers hypothesized that students with lower math skills would choose to start with a lower difficultly level; whereas, students with higher math skills would begin the program by choosing a question with a higher level of difficulty. Results supported these hypotheses. This research also examined the motivational framework guiding students' selection of problem difficulty.

  13. Diapers: What do Parents Choose and Why?

    OpenAIRE

    Shanon, Amir; Feldman, William; James, William; Dulberg, Corinne

    1990-01-01

    Self-administered questionnaires about diaper choices and the reasons for such choices were completed by 600 parents of children younger than two years of age attending a hospital walk-in clinic or the private office of one of four pediatricians. Only 2.7% of the parents used cloth alone; another 15% used both cloth and disposable diapers; a further 18% reported having used cloth at some time. Convenience and rash prevention were reasons for choosing disposable diapers. Those who used only cl...

  14. Choosing a language in international office service encounters

    DEFF Research Database (Denmark)

    Hazel, Spencer

    Choosing a language in international office service encounters – from multilingual miscellany to medium-of-interaction in a matter of seconds Spencer Hazel Roskilde University, Denmark In higher education settings characterized by increasing transnational student and staff mobility, members...... to a multimodal interaction analysis following the ethnomethodological tradition of Conversation Analysis. Gafaranga, J. (2000). Medium repair vs. other-language repair: Telling the medium of a bilingual conversation. International Journal of Bilingualism, 4(3), 327-350. Hall, J. K., Hellermann, J., & Pekarek...... Preisler (eds.) Language alternation, language choice and language encounter in international education. Dordrecht: Springer Preisler, Bent, Ida Klitgård, and Anne H. Fabricius. (2011). Language and learning in the international university: from English uniformity to diversity and hybridity. Bristol...

  15. The Lin28/let-7 axis regulates glucose metabolism

    Science.gov (United States)

    Zhu, Hao; Shyh-Chang, Ng; Segrè, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

    2012-01-01

    SUMMARY The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by blocking let-7 biogenesis. In studies of the Lin28/let-7 pathway, we discovered unexpected roles in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promoted an insulin-sensitized state that resisted high fat diet-induced diabetes, whereas muscle-specific loss of Lin28a and overexpression of let-7 resulted in insulin resistance and impaired glucose tolerance. These phenomena occurred in part through let-7-mediated repression of multiple components of the insulin-PI3K-mTOR pathway, including IGF1R, INSR, and IRS2. The mTOR inhibitor rapamycin abrogated the enhanced glucose uptake and insulin-sensitivity conferred by Lin28a in vitro and in vivo. In addition, we found that let-7 targets were enriched for genes that contain SNPs associated with type 2 diabetes and fasting glucose in human genome-wide association studies. These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism. PMID:21962509

  16. The factors influencing Mathematics students to choose teaching as ...

    African Journals Online (AJOL)

    South African Journal of Education, Volume 38, Number 2, May 2018. 1 ... Second, the global need for STEM-related skills in careers and everyday life is rising, ... an economic factor in developing countries, emerging economies, and in long ... mathematics to guide policy. .... security, time for family, job transferability); social.

  17. Microdosimetry of high LET therapeutic beams

    International Nuclear Information System (INIS)

    Ito, Akira

    1980-01-01

    Experimental microdosimetry of high LET therapeutic beams were presented. The cyclotron produced fast neutron beams at IMS, TAMVEC and NRL, a reactor fast neutron at YAYOI, a proctor beam at Harvard and a pion beam at TRIUMF are included. Measurements were performed with a conventional tissue equivalent spherical proportional counter with a logarithmic amplifier which made the recording and analysis quite simple. All the energy deposition spectra were analysed in the conventional manner and anti y F, anti y D as well as anti y D* were calculated. The spectra and their mean lineal energies showed wide variations, depending on the particle type, energy, position in phantom. Fractional contribution of elemental particles ( electron, muon, pion, proton, alpha and so on) to the total dose were analysed. For fast neutron beams, the y spectra stayed almost constant at any depth along the central axis in the phantom. The y spectra of proton beam changed slightly along the depth. On the other side, the y spectra of pion beam change drastically in the phantom between plateau and dose peak region. A novel technique of time-of-flight microdosimetry was employed, which made it possible to separate the fractional contribution of contaminant electrons and muons out of pions. Finally, a map of the radiation quality for all the beams is presented and its significances are discussed. (author)

  18. Why do men choose to become pedagogues?

    DEFF Research Database (Denmark)

    Wohlgemuth, Ulla Gerner

    2015-01-01

    This article reports the results from a study on reasons for choosing social education for a profession when you are a man. The study concluded that multiple job opportunities and caring for others is a strong motive for men along with possible further studies. The study also disclosed that many...... is one thing, recruiting men to ECE work is quite another matter, especially when gender and ECE hold very strong gender-associated expectations....... men still encounter incomprehension when stating their choice of career. The study is actualised by five new projects supported by the Ministry of Children, Gender Equality, Integration and Social Affairs (MBLIS). These five projects are engaged to seek new ways within attraction and recruitment...

  19. Choosing a public-spirited leader

    DEFF Research Database (Denmark)

    Markussen, Thomas; Tyran, Jean-robert

    2017-01-01

    In this experiment, voters select a leader who can either act in the public interest, i.e. make efficient and equitable policy choices, or act in a corrupt way, i.e. use public funds for private gain. Voters can observe candidates⿿ pro-social behavior and their score in a cognitive ability test...... prior to the election, and this fact is known to candidates. Therefore, self-interested candidates have incentives to act in a pro-social manner, i.e. to pretend to be public-spirited leaders. We find that both truly pro-social and egoistic leaders co-exist, but that political selection is ineffective...... in choosing public-spirited leaders. The main reason is that egoistic candidates strategically pretend to be pro-social to increase their chances of winning the election....

  20. A thermodynamic approach to choosing pervaporatives membranes

    Directory of Open Access Journals (Sweden)

    Mahacine Amrani

    2006-09-01

    Full Text Available This work describes separating a mixture of several components obtained as a product of methyl polymethyl metha- crylate (PMMA thermo-degradation. It was aimed at purifying methyl methacrylate monomer (MMA obtained by 95% mass thermal degradation to reach 99.5% maximum pervaporation concentration. This work studied the theory of pervaporation and applying the main thermodynamic criteria for choosing suitable polymer membranes for separating the MMA/PRP/ISB mixture. Such thermodynamic criteria were based on monomer interaction with and solubility on the membrane. The advantage of using this separation technique lies mainly in the fact that this method has low energy consumption compared to other processes, such as distillation or crystallisation.

  1. Choosing a spent fuel interim storage system

    International Nuclear Information System (INIS)

    Roland, V.; Hunter, I.

    2001-01-01

    The Transnucleaire Group has developed different modular solutions to address spent fuel interim storage needs of NPP. These solutions, that are present in Europe, USA and Asia are metal casks (dual purpose or storage only) of the TN 24 family and the NUHOMS canister based system. It is not always simple for an operator to sort out relevant choice criteria. After explaining the basic designs involved on the examples of the TN 120 WWER dual purpose cask and the NUHOMS 56 WWER for WWER 440 spent fuel, we shall discuss the criteria that govern the choice of a given spent fuel interim storage system from the stand point of the operator. In conclusion, choosing and implementing an interim storage system is a complex process, whose implications can be far reaching for the long-term success of a spent fuel management policy. (author)

  2. Choosing Sport Management as a College Major

    Science.gov (United States)

    Schwab, Keri A.; Dustin, Daniel; Legg, Eric; Timmerman, Danielle; Wells, Mary Sara; Arthur-Banning, Skye G.

    2013-01-01

    The purpose of this study was to better understand sport management students within departments of parks, recreation, and tourism, and to address the often uneasy fit faculty experience when trying to educate sport and recreation students in the same classes. Researchers sent a 16-item online questionnaire to 1,337 undergraduate sport management…

  3. "Let's Move" campaign: applying the extended parallel process model.

    Science.gov (United States)

    Batchelder, Alicia; Matusitz, Jonathan

    2014-01-01

    This article examines Michelle Obama's health campaign, "Let's Move," through the lens of the extended parallel process model (EPPM). "Let's Move" aims to reduce the childhood obesity epidemic in the United States. Developed by Kim Witte, EPPM rests on the premise that people's attitudes can be changed when fear is exploited as a factor of persuasion. Fear appeals work best (a) when a person feels a concern about the issue or situation, and (b) when he or she believes to have the capability of dealing with that issue or situation. Overall, the analysis found that "Let's Move" is based on past health campaigns that have been successful. An important element of the campaign is the use of fear appeals (as it is postulated by EPPM). For example, part of the campaign's strategies is to explain the severity of the diseases associated with obesity. By looking at the steps of EPPM, readers can also understand the strengths and weaknesses of "Let's Move."

  4. Blood-letting in anorexia nervosa: a case study.

    Science.gov (United States)

    Morgan, J F; Lacey, J H

    2000-05-01

    Deliberate blood-letting has been characterized as an alternative to purging behavior in bulimia. We describe a female healthcare worker with an 8-year history of restrictive anorexia nervosa, who initially presented with anemia, using blood-letting, cold baths, and starvation to control her mental state. In contrast with the previous cases of bulimia, the aim of blood-letting in this case of anorexia nervosa was to achieve anemia. She compared the psychic correlates of anemia to emaciation, rather than to deliberate self-harm or purging. We note that mainstream 19th century psychiatry prescribed "baths, blood-letting and diet" as a treatment of "madness." Copyright 2000 by John Wiley & Sons, Inc.

  5. Mouse fecal microbiome after exposure to high LET radiation

    Data.gov (United States)

    National Aeronautics and Space Administration — Space travel is associated with continuous low-dose-rate exposure to high Linear Energy Transfer (LET) radiation. Pathophysiological manifestations after low-dose...

  6. Applicability of LET to single events in microelectronic structures

    Science.gov (United States)

    Xapsos, Michael A.

    1992-12-01

    LET is often used as a single parameter to determine the energy deposited in a microelectronic structure by a single event. The accuracy of this assumption is examined for ranges of ion energies and volumes of silicon appropriate for modern microelectronics. It is shown to be accurate only under very restricted conditions. Significant differences arise because (1) LET is related to energy lost by the ion, not energy deposited in the volume; and (2) LET is an average value and does not account for statistical variations in energy deposition. Criteria are suggested for determining when factors other than LET should be considered, and new analytical approaches are presented to account for them. One implication of these results is that improvements can be made in space upset rate predictions by incorporating the new methods into currently used codes such as CREME and CRUP.

  7. Let the Right One In : Motion picture (2008)

    OpenAIRE

    Buhagiar, Celaine; Lauri Lucente, Gloria

    2009-01-01

    Twilight: A teenage girl risks everything when she falls in love with a vampire. Let the Right One In: Oskar, an overlooked and bullied boy, finds love and revenge through Eli, a beautiful but peculiar girl.

  8. The dependence of relative biological effectiveness from LET

    International Nuclear Information System (INIS)

    Savich, A.V.

    1985-01-01

    A dependence of radiation-chemical yields of DNA injuries on the LET value is found for two transformations - one and two-strand breaks of it. It is shown that the yield of one-strand breaks decreases with the increase of LET value, and the quantity of two-strand breaks at first increases reaching the maximum value within the LET range from 100 up to 150 eV/nm and then decreases. The considered semiempiric theories of the RBE dependences on LET permits using the experimentally determined parameters characterizing radiosensitivity, to estimate the efficiency of the effect of ionizing radiation on cells at different doses, types of radiation and levels of saturation with oxygen. The stage of the cell cycle is also taken into account

  9. Radiosensitivity of yeast cells as a function of radiation LET

    International Nuclear Information System (INIS)

    Lobachevskij, P.N.; Krasavin, E.A.

    1988-01-01

    A model is proposed for interpreting the radiosensitivity of yeast cells as a function of linear energy transfer (LET) of ionizing radiation. The model takes into account the role of repair processes in sensitivity of yeast cells to ionizing radiation of different LET. Two types of repair are discussed: (1) a nonspecific repair (characteristic of both haploid and diploid cells), and (2) a diploid - soecific repair (characteristic of diploid cells only)

  10. Let's Celebrate Personalization: But Not Too Fast

    Science.gov (United States)

    Tomlinson, Carol Ann

    2017-01-01

    The concept of personalization in learning appeals to many K-12 teachers and students weary of regimented, one-size-fits-all instruction. The in-vogue term personalization is used to refer to many different learning strategies and structures--from personal learning plans to greater student voice. Differentiation expert Carol Ann Tomlinson is…

  11. Testing the scalar expectancy theory (SET) and the learning-to-time model (LeT) in a double bisection task.

    Science.gov (United States)

    Machado, Armando; Pata, Paulo

    2005-02-01

    Two theories of timing, scalar expectancy theory (SET) and learning-to-time (LeT), make substantially different assumptions about what animals learn in temporal tasks. In a test of these assumptions, pigeons learned two temporal discriminations. On Type 1 trials, they learned to choose a red key after a 1-sec signal and a green key after a 4-sec signal; on Type 2 trials, they learned to choose a blue key after a 4-sec signal and a yellow key after either an 8-sec signal (Group 8) or a 16-sec signal (Group 16). Then, the birds were exposed to signals 1 sec, 4 sec, and 16 sec in length and given a choice between novel key combinations (red or green vs. blue or yellow). The choice between the green key and the blue key was of particular significance because both keys were associated with the same 4-sec signal. Whereas SET predicted no effect of the test signal duration on choice, LeT predicted that preference for green would increase monotonically with the length of the signal but would do so faster for Group 8 than for Group 16. The results were consistent with LeT, but not with SET.

  12. LET effects on normal and radiosensitive cell lines

    International Nuclear Information System (INIS)

    Geard, C.R.; Travisano, M.

    1986-01-01

    Charged particles in the track segment mode were produced by the RARAF Van de Graaff accelerator and used to irradiate two CHO cell lines, a radiosensitive hypermutable line EM9 and its normal parent AA8. Asynchronous cells were irradiated attached to 6 micrometer thick Mylar with protons, deuterons and helium-3 particles at LETs ranging from 10 to 150 keV per micrometer. A 50 kVp x-ray tube integrated into the track segment facility provided a low LET comparison. Following irradiation cells were monitored for clonogenicity, and in a separate series of experiments frequencies of sister chromatid exchanges. Up to 9 experiments were carried out at each LET, with a total of 8 radiations of different LETs being compared. The optimally effective LET for cell survival was between 80 and 120 keV per micrometer, with the 150 keV per micrometer particles indicating energy wastage. The differential between the normal and radiosensitive cell lines was maintained at all LETs

  13. Adaptive response to high LET radiations

    International Nuclear Information System (INIS)

    Dam, Annamaria; Bogdandi, E. Noemi; Polonyi, Istvan; Sardy, M. Marta; Balashazy, Imre; Palfalvy, Jozsef

    2001-01-01

    The biological consequences of exposure to ionizing radiation include gene mutation, chromosome aberrations, cellular transformation and cell death. These effects are attributed to the DNA damaging effects of the irradiation resulting in irreversible changes during DNA replication or during the processing of the DNA damage by enzymatic repair processes. These repair processes could initiate some adaptive mechanisms in the cell, which could lead to radioadaptive response (RAR). Adaptive responses have typically been detected by exposing cells to a low radiation dose (1-50 mGy) and then challenging the cells with a higher dose of radiation (2-4 Gy) and comparing the outcome to that seen with the challenge dose only. For adaptive response to be seen the challenge dose must be delivered within 24 hour of the inducing dose. Radio-adaptation is extensively studied for low LET radiation. Nevertheless, few data are available for high LET radiation at very low doses and dose rate. Our study was aimed to investigate the radioadaptive response to low-dose neutron irradiation by detection of the genotoxic damage i.e.: hprt-mutant colonies induced. Altered protein synthesis was also studied to identify stress proteins may responsible for radio-adaptation. New alpha particle irradiator system was also built up to study the biological effects of low dose alpha irradiation. The experiments were carried out on monolayers of human melanoma and CHO (Chines Hamster Ovary) cells irradiated by neutrons produced in the biological irradiation channel of the Research Reactor of Budapest Neutron Center. Cells were exposed to 0.5-50 mGy neutron doses with dose rates of 1.59-10 mGy/min. The challenge doses of 2-4 Gy gamma rays were administrated within 1-48 hours after priming treatment. The induced mutants at hprt locus were selected by adding 6-thioguanine and allow to grow for 10 days for expression of the phenotype. The protein synthesis was studied by PAGE, the molecular mass of specific

  14. For Better Soil, Let Earthworms Toil.

    Science.gov (United States)

    Swinehart, Rebecca, Ed.

    1995-01-01

    This activity involves elementary students in investigating how earthworms affect soil fertility. An introduction discusses topsoil loss and the connections between soil and earthworm ecology. Materials needed and step-by-step procedure are provided. (LZ)

  15. Choosing Health and the inner citadel.

    Science.gov (United States)

    Allmark, P

    2006-01-01

    It is argued in this paper that the latest UK government white paper on public health, Choosing Health, is vulnerable to a charge of paternalism. For some years libertarians have levelled this charge at public health policies. The white paper tries to avoid it by constant reference to informed choice and choice related terms. The implication is that the government aims only to inform the public of health issues; how they respond is up to them. It is argued here, however, that underlying the notion of informed choice is a Kantian, "inner citadel" view of autonomy. According to this view, each of us acts autonomously only when we act in accord with reason. On such a view it is possible to justify coercing, cajoling, and conning people on the basis that their current behaviour is not autonomous because it is subject to forces that cause irrational choice, such as addiction. "Informed choice" in this sense is compatible with paternalism. This paternalism can be seen in public health policies such as deceptive advertising and the treatment of "bad habits" as addictions. Libertarians are bound to object to this. In the concluding section, however, it is suggested that public health can, nonetheless, find ethical succour from alternative approaches.

  16. Free to choose. The Buddhist view.

    Science.gov (United States)

    Gnanawimala, B

    1993-10-27

    This Buddhist view of family planning is presented by a lecturer at the Buddhist and Pali University in Colombo. Birth control was not mentioned in the earliest Buddhist teachings because there was no urgency for population control. Large families were honored, and the expectation was that as many children as possible should be produced. Buddha did not mention the merits of population increase. Buddha considered family size a personal family choice. Buddhist's disciples are expected to be celibate. Chastity is encouraged among men and women. The Dhammapada, a canonical work of Buddha, mentions not increasing population and teaches ways of keeping the mind free from lust. Reduction of births is recommended. Buddha placed importance on the right of human beings to exist and procreate peacefully. The right to life begins in the womb, and abortion is a violation of the rights of the unborn child. The formation of life is absolutely dependent upon a mother's physical fitness, sexual intercourse, and the arrival of "a being's dislocated transmigratory unit of fivefold energy (gandhabba)." Couples are free to choose a fetus from any energy body. Sterilization and the use of contraceptives, therefore, do not destroy life. Buddha commended abstinence, which is similar to chastity. The principle teachings of Buddha aim to end suffering. If procreation strains the ability of resources to support life, then procreation is against the basic principles of Buddha.

  17. Choosing Health and the inner citadel

    Science.gov (United States)

    Allmark, P

    2006-01-01

    It is argued in this paper that the latest UK government white paper on public health, Choosing Health, is vulnerable to a charge of paternalism. For some years libertarians have levelled this charge at public health policies. The white paper tries to avoid it by constant reference to informed choice and choice related terms. The implication is that the government aims only to inform the public of health issues; how they respond is up to them. It is argued here, however, that underlying the notion of informed choice is a Kantian, “inner citadel” view of autonomy. According to this view, each of us acts autonomously only when we act in accord with reason. On such a view it is possible to justify coercing, cajoling, and conning people on the basis that their current behaviour is not autonomous because it is subject to forces that cause irrational choice, such as addiction. “Informed choice” in this sense is compatible with paternalism. This paternalism can be seen in public health policies such as deceptive advertising and the treatment of “bad habits” as addictions. Libertarians are bound to object to this. In the concluding section, however, it is suggested that public health can, nonetheless, find ethical succour from alternative approaches. PMID:16373514

  18. Letting girls speak out about science

    Science.gov (United States)

    Baker, Dale; Leary, Rosemary

    The purpose of this study was to try to determine what influences girls to choose science. Forty girls were interviewed in Grades 2, 5, 8, 11 using a semistructured protocol. The interview focused on feelings about science, science careers, peer and parental support, and how science is taught. To determine whether their responses were based on gender, each girl was asked to respond to questions as if she were a boy. The girls were highly self-confident and positive about science. All of the girls took a strong equity position and asserted that women can and should do science. The girls liked learning science in an interactive social context rather than participating in activities that isolated them such as independent reading, writing, or note taking. Those who chose science careers were drawn to them because of strong affective experiences with a loved one and a desire to help. The interviews were analyzed through the framework of women's affective and psychological needs.Received: 15 July 1993; Revised: 23 May 1994;

  19. Why Do They Choose Their Instruments?

    Science.gov (United States)

    Cantero, Irene Martínez; Jauset-Berrocal, Jordi-Angel

    2017-01-01

    Motivation is a key word in the arts and, especially, in music since it conveys collective, as well as individual, feelings. The beginning of musical instrument learning should be based on the student's musical interest but, due to the casual and improvised nature of everyday situations in which the choice of a musical instrument takes place, tend…

  20. Choosing Teaching as a Career: Importance of the Type of Motivation in Career Choices

    Directory of Open Access Journals (Sweden)

    Robert Tomšik

    2016-08-01

    Full Text Available This research looks into what are Extrinsic, Intrinsic and Altruistic motives and their importance when students are choosing their career. The study involved 324 teacher trainees in their first year of bachelor studies. The types of motivation when choosing teaching career were studied by SMVUP2-S (Teaching Career Choice Scale. The model of motivation types was supplemented by subscales: Influence by other, Career growth and Alternative choice. Objective of the study was to show the relationship between these variables. Results from the research showed that influence by other and alternative choice of teaching career were in a negative relation with interest and skills/experience that this career requires and students should have.

  1. Biomarkers specific to densely-ionising (high LET) radiations

    International Nuclear Information System (INIS)

    Brenner, D.J.; Okladnikova, N.; Hande, P.; Burak, L.; Geard, C.R.; Azizova, T.

    2001-01-01

    There have been several suggestions of biomarkers that are specific to high LET radiation. Such a biomarker could significantly increase the power of epidemiological studies of individuals exposed to densely-ionising radiations such as alpha particles (e.g. radon, plutonium workers, individuals exposed to depleted uranium) or neutrons (e.g. radiation workers, airline personnel). We discuss here a potentially powerful high LET biomarker (the H value) which is the ratio of induced inter-chromosomal aberrations to intra-arm aberrations. Both theoretical and experimental studies have suggested that this ratio should differ by a factor of about three between high LET radiation and any other likely clastogen, and will yield more discrimination than the previously suggested F value (ratio of inter-chromosomal aberrations to intra-chromosomal inter-arm aberrations). Evidence of the long-term stability of such chromosomal biomarkers has also been generated. Because these stable intra-arm and inter-chromosomal aberrations are (1) frequent and (2) measurable at long times after exposure, this H value appears to be a practical biomarker of high LET exposure, and several in vitro studies have confirmed the approach for unstable aberrations. The approach is currently being tested in a population of Russian radiation workers exposed several decades ago to high- or low LET radiation. (author)

  2. A simple theory of LET spectra of heavy ion beams

    International Nuclear Information System (INIS)

    Wilson, J.W.; Townsend, L.W.; Schimmerling, W.; Norbury, J.W.; Wong, M.; Badavi, F.

    1985-01-01

    The transition of high energy ion beams through extended matter is of considerable interest to the space program as well as radiobiology and medical therapy. The transition is defined in terms of various atomic/molecular and nuclear cross sections in a Boltzmann-like equation. One dimensional solutions are derived herein from which LET spectra are derived for secondary fragments. Such LET spectra are fundamental to the evaluation of beam quality, biological effects, and radiation shield effectiveness. Sensitivity of LET spectral distributions to uncertainty in physical parameters such as the isotopic fragmentation parameters, fragment mass, and absorption cross section is established for a number of ion beams. The main limitation in LET studies is the paucity of both elemental and isotopic fragmentation data. The elemental fragmentation data is more readily available because of its simple experimental procedures. It has been suggested by some that natural abundance ratios should be used with the elemental cross sections but this leads to an order-of-magnitude error in LET spectra in many cases. Very few examples of isotopic fragmentation measurements are available. Although major advances in nuclear fragmentation theory have been made, we must await more extensive isotopic fragmentation experiments for final validation

  3. Fast Neutrons - LET Distributions and the Response of Mammalian Cells

    Energy Technology Data Exchange (ETDEWEB)

    Bewley, D. K. [Medical Research Council Cyclotron Unit, Hammersmith Hospital, London (United Kingdom)

    1968-03-15

    Distributions of stopping power (LET) are given for four beams of fast neutrons, namely, neutrons of 14.6 MeV, neutrons produced by bombarding a thick beryllium target with 15 MeV deuterons, neutrons of 3 MeV, and fast neutrons produced by bombardment of a {sup 235}U converter plate with thermal neutrons. The track average LET is correlated with mean neutron energy, but the dose average is approximately constant. However, neither of these types of average is expected to have much relevance to radiobiology. Further, specification of a ''biologically effective LET'' depends on the biological test used, and is not solely a function of the radiation quality. An attempt has been made to calculate the response of T.I. kidney cells in tissue culture to these four beams of neutrons, based on their response to charged particles using the track-segment method. The calculated RBE's of the neutron beams are lower than the observed values and the calculated values of the oxygen enhancement ratio are higher. These differences seem too great to be explained by errors in dosimetry and in the calculated LET spectra. The suggestion is made that LET is not an adequate criterion of radiation quality, and that the discrepancies may be explained by more detailed consideration of the part played by delta rays and by heavy recoil tracks of short range. (author)

  4. The inactivation of papain by high LET radiations

    International Nuclear Information System (INIS)

    Bisby, R.H.; Cundall, R.B.; Sims, H.E.; Burns, W.G.

    1984-01-01

    The effect of varying LET over a wide range (0.2-1570 eV/nm) on the radiation-induced inactivation of the enzyme papain in dilute aqueous solution has been investigated. Measurements of total, reparable and non-reparable inactivation G values in oxygen, nitrous oxide and argon saturated solutions have allowed the contributions to inactivation from radicals and hydrogen peroxide to be evaluated. At high LET the results demonstrate an increasing component due to reaction of the superoxide radical, formed from oxygen produced in the track as a primary radiolysis product. This effect was not observed in our previous study with ribonuclease due to the insensitivity of ribonuclease to inactivation by superoxide and hydrogen peroxide. The results obtained with papain clearly demonstrate a maximum in G(H 2 O 2 ) at an LET of equivalent to 140 eV/nm. Generation of O 2 within the track as a primary radiolysis product at high LET now appears to be confirmed as an important mechanism leading to reduction in the oxygen enhancement ratio for cellular systems exposed to high LET radiations (Baverstock and Burns 1981). (author)

  5. Brain Gym: Let the User Beware

    Science.gov (United States)

    Kroeze, Kevin; Hyatt, Keith; Lambert, Chuck

    2015-01-01

    As part of the No Child Left behind Act of 2001 and the Individuals with Disabilities Education Improvement Act of 2004, schools are called upon to provide students with academic instruction using scientific, research-based methods whenever possible. One of these supposed research-based methods is a program by the name of Brain Gym®. Brain Gym® is…

  6. Odaminodaa Ojibwemong!! = Let's Play in Ojibwe!!

    Science.gov (United States)

    White, James L.

    The booklet contains directions for designing six word games to provide motivation, reinforcement, and review for students of all ages, from children to adults, as they learn the Ojibwe language. Step-by-step instructions are provided for making and playing Quiz Board, Tic-Tac-Toe, Concentration, Lottery, Lingo (Bingo), and Incocomp. Suggestions…

  7. Motives and career barriers choosing studies in Physics and Mathematics: gender aspects

    Directory of Open Access Journals (Sweden)

    Aldona, Augustiene

    2010-04-01

    Full Text Available This article discusses the concepts of professional motivation and career barriers from the gender point of view. The research problem is expressed in the following questions: what personal and socio-cultural factors motivate young people to choose Physics and Mathematics study programmes? Are there significant differences in expression of motives and career barriers among male and female students? The sample consisted of 86 undergraduate students: 45 females and 41 male. Respondents were asked to write down their reflections as a free text answering the question why did they make such a professional choice choosing Physics and Mathematics studies. Motives that influenced the choice of Physics and Mathematics mostly expressed the dimension of self-realization and the dimension of material achievements. It was also found that both personality and social-cultural factors were important in choosing Physics and Mathematics, i.e. sensation of vocation and professional aptitude, as well as encouragement of relatives and good evaluation of future profession’s status. There were also found differences in expression of motives and career barriers among male and female students.

  8. Mutagenic effect of radiations of various LET on Salmonella cells

    International Nuclear Information System (INIS)

    Kozubek, S.; Krasavin, E.A.; Amirtaev, K.G.; Tokarova, B.; Basha, S.G.

    1989-01-01

    Regularities of mutagenic effect of heavy charged particles of helium, deuterium ions and protons on various strains of Salmonella typhimurium were studied. Linear dose dependences of mutation frequency in the range of low doses were revealed. A conclusion was made that mutation process at low dose irradiation is determined in various teststrains of Salmonella typhimurium by certain premutation injuries. Quite a different picture is observed in mutation process in case of high dose irradiation where effect of inducible SOS-repair is distinctly manifested. Not only spectra of primary DNA injuries but probability of their fixation into mutation can change with the increase of LET. If fixation probability doesn't change with LET increase for replicative mutagenesis which make basis contribution to linear component of dose dependence of mutation frequency the probability of fixation is increased for reparative mutagenesis. It accounts for increase of values of relative genetic efficiency with LET increase. 7 refs.; 6 figs.; 1 tab

  9. High LET radiation and mechanism of DNA damage repair

    International Nuclear Information System (INIS)

    Furusawa, Yoshiya

    2004-01-01

    Clarifying the mechanism of repair from radiation damage gives most important information on radiation effects on cells. Approximately 10% of biological experiments groups in Heavy Ion Medical Accelerator in Chiba (HIMAC) cooperative research group has performed the subject. They gave a lot of new findings on the mechanism, and solved some open questions. The reason to show the peak of relative biological effectiveness RBE at around 100-200 keV/μm causes miss-repair of DNA damage. Sub-lethal damage generated by high linear energy transfer (LET) radiation can be repaired fully. Potentially lethal damages by high-LET radiation also repaired, but the efficiency decreased with the LET, and so on. (author)

  10. LET dependence of scintillation yields in liquid argon

    Energy Technology Data Exchange (ETDEWEB)

    Doke, Tadayoshi; Hitachi, Akira; Kikuchi, Jun; Crawford, H J; Lindstrom, P J; Masuda, Kimiaki; Shibamura, Eido; Takahashi, Tan

    1988-06-01

    Scintillation yields (scintillation intensity per unit absorbed energy) in liquid argon for ionizing particles are reviewed as a function of LET for the particles. The maximum scintillation yield, which is obtained for relativistic heavy ions from Ne to La, is about 1.2 times larger than that for gamma rays in NaI(Tl) crystal. In the low LET region, the scintillation yields for relativistic electrons, protons and He ions are 10-20% lower than the maximum yield. This tendency can be explained by taking into account the existence of the electrons which have escaped from their parent ions. In the high LET region, a quenching effect due to high ionization density is observed for alpha particles, fission fragments and relativistic Au ions.

  11. How to choose a delegation for a peace conference?

    NARCIS (Netherlands)

    Can, Burak; Csóka, Péter; Ergin, Emre

    2017-01-01

    This paper analyzes how to choose a delegation, a committee to represent a society such as in a peace conference. We propose normative conditions and seek optimal, consistent, neutral and non-manipulable ways to choose a delegation. We show that a novel class of threshold rules are characterized by

  12. Hearing Aids: How to Choose the Right One

    Science.gov (United States)

    Hearing aids: How to choose the right one Many types of hearing aids exist. So which is best for you? Find out what to consider when choosing a hearing ... used to the device and decide if it's right for you. Have the dispenser put in writing ...

  13. Choosing and Using Images in Environmental Science Education

    Science.gov (United States)

    Muthersbaugh, Debbie Smick

    2012-01-01

    Although using images for teaching has been a common practice in science classrooms (Gordon & Pea, 1995) understanding the purpose or how to choose images has not typically been intentional. For this dissertation three separate studies relating to choosing and using images are prepared with environmental science in mind. Each of the studies…

  14. Learning, Leading, and Letting Go of Control

    DEFF Research Database (Denmark)

    Iversen, Ann-Merete; Pedersen, Anni Stavnskær; Kjær-Rasmussen, Lone Krogh

    2015-01-01

    The article introduces a new term in higher education: learner-led approaches in education (LED). This does not represent a single approach or dogma to replace existing dogmas, but a way of approaching learning and education that mirrors the complexity of society as it develops. LED is based...... on the assumption that all students have their own unique approach to learning and therefore have the potential to design learning processes that are meaningful for them. This removes focus from the teacher and the teaching to the learner and the learning. It builds on the student’s motivation and experienced...... meaningfulness as a driving force, and hence the term learner led. The methods applied in LED change over time, as different learners and teachers together co-create and design methods and approaches appropriate at that particular time, in that particular context and for that particular student or group...

  15. Apoptosis induced by high- and low-LET radiations

    International Nuclear Information System (INIS)

    Hendry, J.H.; Potten, C.S.; Merritt, A.

    1995-01-01

    Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals. (orig.)

  16. Prophage λ induction by ionizing radiation of different LETs

    International Nuclear Information System (INIS)

    Bonev, M.N.; Kozubek, S.; Krasavin, E.A.; Amirtaev, K.G.

    1988-01-01

    The λ prophage induction caused by γ-irradiation and accelerated heavy ions with different LET was studied in variety Escherichia coli strains. The induction frequency on the dose I(D) shaped a curve with a maximum in the strains which possess recA + /lexA + genotype. The inductivity of these strains increases as well as LET and an alteration poor → rich media does it. Unlike I(D) for recA + /lexA + , the dependence I(D) for recA, lexA and recBC strains was a constant. 15 refs.; 6 figs.; 3 tabs

  17. Choosing your IoT programming framework : architectural aspects

    NARCIS (Netherlands)

    Rahman, L.F.; Ozcelebi, T.; Lukkien, J.J.

    2016-01-01

    The Internet of Things (IoT) is turning into practice. To drive innovations, it is crucial that programmers have means to develop IoT applications in the form of IoT programming frameworks. These are toolkits to develop applications according to a certain style or method and that let developers

  18. A critique of Katz's 'High LET constraint on low LET survival'

    International Nuclear Information System (INIS)

    Burch, P.R.J.; Chesters, M.S.

    1979-01-01

    Katz's interpretation of the connexion between RBE and LET is contrasted with a version published previously by Burch. The implications of Katz's model for dose-response relations apply only at ultra-high absorbed doses in Burch's model. In the latter, the shoulder on type-C survival curves for mammalian cells is explained in terms of Haynes' repair model. Under certain conditions the repair model becomes mathematically equivalent to the α-β model; under some other conditions it becomes equivalent to the 'two-component' model. The formulation of a new repair hypothesis, based on the idea of an inducible repair mechanism, is also set out. It is argued that Katz's supralinearity index' is appropriate to the induction of (rare) mutations but inappropriate to cell survival, for which an alternative index is proposed. Certain plausible hypotheses of radiobiological action conflict with Katz's 'logical constraint' which, it is contended, is neither logical nor valid. In conclusion, although experimental findings for some radiobiological systems conform to Katz's 'constraint', the frequently observed violations should not necessarily be regarded as artefacts. (author)

  19. Biological fingerprint of high LET radiation. Brenner hypothesis

    International Nuclear Information System (INIS)

    Kodama, Yoshiaki; Awa, Akio; Nakamura, Nori

    1997-01-01

    Hypothesis by Brenner et al. (1994) that in chromosome aberrations in human peripheral lymphocytes induced by radiation exposure, F value (dicentrics/rings) differs dependently on the LET and can be a biomarker of high LET radiation like neutron and α-ray was reviewed and evaluated as follows. Radiation and chromosome aberrations; in this section, unstable aberrations like dicentric and rings (r) and stable ones like translocation and pericentric inversions were described. F value. Brenner hypothesis. Bauchinger's refutation. F value determined by FISH method; here, FISH is fluorescence in situ hybridization. F value in studies by author's Radiation Effect Research Facility. Frequency of chromosome aberration in A-bomb survivors and ESR (ESR: electron spin resonance). The cause for fluctuation of F values. The Brenner hypothesis could not be supported by studies by author's facility, suggesting that the rate of inter-chromosomal and intra-chromosomal exchange abnormalities can not be distinguishable by the radiation LET. This might be derived from the difference in detection technology of r rather than in LET. (K.H.)

  20. Irradiation of single cells with individual high-LET particles

    International Nuclear Information System (INIS)

    Nelson, J.M.; Braby, L.A.

    1993-01-01

    The dose-limiting normal tissue of concern when irradiating head and neck lesions is often the vascular endothelium within the treatment field. Consequently, the response of capillary endothelial cells exposed to moderate doses of high LET particles is essential for establishing exposure limits for neutron-capture therapy. In an effort to characterize the high-LET radiation biology of cultured endothelial cells, the authors are attempting to measure cellular response to single particles. The single-particle irradiation apparatus, described below, allows them to expose individual cells to known numbers of high-LET particles and follow these cells for extended periods, in order to assess the impact of individual particles on cell growth kinetics. Preliminary cell irradiation experiments have revealed complications related to the smooth and efficient operation of the equipment; these are being resolved. Therefore, the following paragraphs deal primarily with the manner by which high LET particles deposit energy, the requirements for single-cell irradiation, construction and assembly of such apparatus, and testing of experimental procedures, rather than with the radiation biology of endothelial cells

  1. Let's Play: Exploring Literacy Practices in an Emerging Videogame Paratext

    Science.gov (United States)

    Burwell, Catherine; Miller, Thomas

    2016-01-01

    This article explores the literacy practices associated with Let's Play videos (or LPs) on YouTube. A hybrid of digital gaming and video, LPs feature gameplay footage accompanied by simultaneous commentary recorded by the player. Players may set out to promote, review, critique or satirize a game. In recent years, LPs have become hugely popular…

  2. Operation of a hemispherical detector for LET measurements

    International Nuclear Information System (INIS)

    Schell, M.C.; DeLuca, P.M. Jr.; Pearson, D.W.

    1982-01-01

    A hemispherical ΔE/E detector has been constructed and tested for the measurement of linear-energy-transfer distributions of charged particles induced by fast neutrons. The initial performance test results and LET distributions from 14.8-MeV monoenergetic neutron irradiation in free space of carbon, lead, and Al50-plastic are presented

  3. Evaluation of normal tissue responses to high-LET radiations

    International Nuclear Information System (INIS)

    Halnan, K.E.

    1979-01-01

    Clinical results presented have been analysed to evaluate normal tissue responses to high-LET radiations. Damage to brain, spinal cord, gut, skin, connective tissue and bone has occurred. A high RBE is probable for brain and possible for spinal cord and gut but other reasons for damage are also discussed. A net gain seems likely. Random controlled trials are advocated. (author)

  4. Choosing in Freedom or Forced to Choose? Introspective Blindness to Psychological Forcing in Stage-Magic

    Science.gov (United States)

    Shalom, Diego E.; de Sousa Serro, Maximiliano G.; Giaconia, Maximiliano; Martinez, Luis M.; Rieznik, Andres; Sigman, Mariano

    2013-01-01

    We investigated an individual ability to identify whether choices were made freely or forced by external parameters. We capitalized on magical setups where the notion of psychological forcing constitutes a well trodden path. In live stage magic, a magician guessed cards from spectators while inquiring how freely they thought they had made the choice. Our data showed a marked blindness in the introspection of free choice. Spectators assigned comparable ratings when choosing the card that the magician deliberately forced them compared to any other card, even in classical forcing, where the magician literally handles a card to the participant This observation was paralleled by a laboratory experiment where we observed modest changes in subjective reports by factors with drastic effect in choice. Pupil dilatation, which is known to tag slow cognitive events related to memory and attention, constitutes an efficient fingerprint to index subjective and objective aspects of choice. PMID:23516455

  5. Choosing in freedom or forced to choose? Introspective blindness to psychological forcing in stage-magic.

    Directory of Open Access Journals (Sweden)

    Diego E Shalom

    Full Text Available We investigated an individual ability to identify whether choices were made freely or forced by external parameters. We capitalized on magical setups where the notion of psychological forcing constitutes a well trodden path. In live stage magic, a magician guessed cards from spectators while inquiring how freely they thought they had made the choice. Our data showed a marked blindness in the introspection of free choice. Spectators assigned comparable ratings when choosing the card that the magician deliberately forced them compared to any other card, even in classical forcing, where the magician literally handles a card to the participant This observation was paralleled by a laboratory experiment where we observed modest changes in subjective reports by factors with drastic effect in choice. Pupil dilatation, which is known to tag slow cognitive events related to memory and attention, constitutes an efficient fingerprint to index subjective and objective aspects of choice.

  6. Don't Let Osteoporosis Slow You Down | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... has never let anything stop her from doing what she loves, and she wasn't about to let osteoporosis keep her off the dance floor. It's that kind of spirit that led the National Osteoporosis Foundation (NOF) to ...

  7. Friends Don't Let Friends Drive Drunk, But Do They Let Friends Drive High?

    Science.gov (United States)

    Glascoff, Mary A.; Shrader, Joe S.; Haddock, Rose K.

    2013-01-01

    This study reports on a study of college students at a state supported university regarding the use of designated drivers associated with illicit drug use, especially marijuana use. The purpose of the study was to examine whether college students report that they drive under the influence of illicit drugs, if they use the strategy of designating a…

  8. Molecular analysis of two genes between let-653 and let-56 in the unc-22(IV) region of Caenorhabditis elegans.

    Science.gov (United States)

    Marra, M A; Prasad, S S; Baillie, D L

    1993-01-01

    A previous study of genomic organization described the identification of nine potential coding regions in 150 kb of genomic DNA from the unc-22(IV) region of Caenorhabditis elegans. In this study, we focus on the genomic organization of a small interval of 0.1 map unit bordered on the right by unc-22 and on the left by the left-hand breakpoints of the deficiencies sDf9, sDf19 and sDf65. This small interval at present contains a single mutagenically defined locus, the essential gene let-56. The cosmid C11F2 has previously been used to rescue let-56. Therefore, at least some of C11F2 must reside in the interval. In this paper, we report the characterization of two coding elements that reside on C11F2. Analysis of nucleotide sequence data obtained from cDNAs and cosmid subclones revealed that one of the coding elements closely resembles aromatic amino acid decarboxylases from several species. The other of these coding elements was found to closely resemble a human growth factor activatable Na+/H+ antiporter. Paris of oligonucleotide primers, predicted from both coding elements, have been used in PCR experiments to position these coding elements between the left breakpoint of sDf19 and the left breakpoint of sDf65, between the essential genes let-653 and let-56.

  9. Color waves : a simple heuristic for choosing false colors

    NARCIS (Netherlands)

    Overveld, van C.W.A.M.

    1997-01-01

    A simple heuristic is presented for choosing false colors for visualizing scalar functions on two-dimensional domains. The color scheme allows inspection of the function on several length scales simultanously.

  10. Choosing the right health care provider for pregnancy and childbirth

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000596.htm Choosing the right health care provider for pregnancy and childbirth To use the sharing features on this page, please enable JavaScript. ...

  11. Choosing a doctor and hospital for your cancer treatment

    Science.gov (United States)

    ... htm Choosing a doctor and hospital for your cancer treatment To use the sharing features on this page, please enable JavaScript. When you seek cancer treatment, you want to find the best care possible. ...

  12. How to Choose the Best Skin Care Products

    Science.gov (United States)

    ... Skin Care Products How to Choose the Best Skin Care Products Looking for a quick fix to erase wrinkles, ... available, the beauty aisle can be overwhelming. Some skin care products are overpriced and make claims they can’t ...

  13. Choosing the Right Fireplace or Fireplace Retrofit Device

    Science.gov (United States)

    This page is about choosing a fireplace or fireplace retrofit device, including information on hang tags and a list of fireplaces and retrofits that have qualified under the voluntary fireplace program

  14. Let's Get Physical: Teaching Physics Through Gymnastics

    Science.gov (United States)

    Sojourner, Elena J.; Burgasser, Adam J.; Weise, Eric D.

    2018-01-01

    The concept of embodied learning—that we can learn with our bodies and with our minds—is a well-established concept in physics and math education research, and includes symbolic understanding (e.g., gestures that track how students think or facilitate learning to model complex systems of energy flow) as well as the literal experience of exploring physical phenomena through body movements. Sport has long served as a guide for both illustrating and experiencing physical concepts and phenomena, with a particularly relevant example being the sport of gymnastics. Here, the practitioner is subjected to a wide range of forces and torques, and experiences translational and rotational motions, all guided by control of body positioning, shape, strength, and leverage. Smith provides a comprehensive study of the mechanics used to analyze gymnastic movements, which includes core concepts such as force balance, leverage and torque, center of mass and stability, moment of inertia, ballistic motion, pendulum motion, and circular motion. For life science majors, gymnastics also provides relevant physical examples of biomechanics and the physical limits of biological materials (skin, bones, ligaments). The popularity of gymnastics—consider the phenomenon of Simone Biles—makes it broadly accessible and engaging, particularly across genders.

  15. Influence of gender in choosing a career amongst engineering fields: a survey study from Turkey

    Science.gov (United States)

    Bucak, Seyda; Kadirgan, Neset

    2011-10-01

    The aim of this study is to understand the motivating factors behind students' choices in their decision-making process and also get an insight on their perception of different engineering branches. A survey was prepared and the results were evaluated amongst 1163 answers. Two major influences on student's decision in their professional choices are shown to be career services and family members. Generally, students have claimed to choose a profession based on 'finding a job' and 'being happy'. Some engineering branches such as Genetic and Bioengineering, Chemical Engineering, Environmental Engineering and Industrial Engineering, are shown to be distinctly preferred by female students, whereas mechanical, civil and electronic engineering are favourites for male students. The survey results were also compared with the distribution of male and female students in various engineering departments. This study clearly shows that certain engineering branches are perceived as more appropriate for women and are thus favoured by female students, while those perceived as more appropriate for men are favoured by male students.

  16. LET effect on irradiation of hydroxyphthal imide in alcohol solutions

    International Nuclear Information System (INIS)

    Nakagawa, S.; Murakami, T.

    2005-01-01

    Hydroxyphthalimide(C 6 H 4 (CO) 2 -NOH) was irradiated with C ion (290MeV/u) in isopropyl alcohol, methanol, ethanol, and acetonitrile. LET was 13.2 and 26.5 keV/m. Dose was 5 and 10 kGy. A little amount of phthalimide was produced. The G value of the production of phthalimide by ion irradiation was less than that by -irradiation except for in methanol. In methanol solution, the production rate of phthalimide increased with increasing the value of LET. The amount of the substitution for C 6 H 4 (CO) 2 -NOD in methanol-d decreased by ion irradiation. These results suggest that the reaction mechanism in ion irradiation is different from -irradiation. (author)

  17. Neoplastic cell transformation by high-LET radiation - Molecular mechanisms

    Science.gov (United States)

    Yang, Tracy Chui-Hsu; Craise, Laurie M.; Tobias, Cornelius A.; Mei, Man-Tong

    1989-01-01

    Quantitative data were collected on dose-response curves of cultured mouse-embryo cells (C3H10T1/2) irradiated with heavy ions of various charges and energies. Results suggests that two breaks formed on DNA within 80 A may cause cell transformation and that two DNA breaks formed within 20 A may be lethal. From results of experiments with restriction enzymes which produce DNA damages at specific sites, it was found that DNA double strand breaks are important primary lesions for radiogenic cell transformation and that blunt-ended double-strand breaks can form lethal as well as transformational damages due to misrepair or incomplete repair in the cell. The RBE-LET relationship for high-LET radiation is similar to that for HGPRT locus mutation, chromosomal deletion, and cell transformation, indicating that common lesions may be involved in these radiation effects.

  18. Owning, letting and demanding second homes in Denmark

    DEFF Research Database (Denmark)

    Bloze, Gintautas; Skak, Morten

    with administrative register data and presents estimations of the probability of owning a second home, the decision to let the second home and the number of let weeks per year. Also income elasticities for primary and second housing demand are estimated. We find a conventional monotonic increase in demand...... elasticities for primary housing demand for non-owners of second homes; however, owners of second homes have the highest income elasticity in the middle income group.......An increasing number of households consume housing beyond the primary home as owners of a second home. Economic studies of non-speculative demand for second homeownership are still scarce, and the present empirical study fills this gap to some extent. It is based on Danish survey data combined...

  19. Value of freedom to choose encoded by the human brain

    Science.gov (United States)

    Fujiwara, Juri; Usui, Nobuo; Park, Soyoung Q.; Williams, Tony; Iijima, Toshio; Taira, Masato; Tsutsui, Ken-Ichiro

    2013-01-01

    Humans and animals value the opportunity to choose by preferring alternatives that offer more rather than fewer choices. This preference for choice may arise not only from an increased probability of obtaining preferred outcomes but also from the freedom it provides. We used human neuroimaging to investigate the neural basis of the preference for choice as well as for the items that could be chosen. In each trial, participants chose between two options, a monetary amount option and a “choice option.” The latter consisted of a number that corresponded to the number of everyday items participants would subsequently be able to choose from. We found that the opportunity to choose from a larger number of items was equivalent to greater amounts of money, indicating that participants valued having more choice; moreover, participants varied in the degree to which they valued having the opportunity to choose, with some valuing it more than the increased probability of obtaining preferred items. Neural activations in the mid striatum increased with the value of the opportunity to choose. The same region also coded the value of the items. Conversely, activation in the dorsolateral striatum was not related to the value of the items but was elevated when participants were offered more choices, particularly in those participants who overvalued the opportunity to choose. These data suggest a functional dissociation of value representations within the striatum, with general representations in mid striatum and specific representations of the value of freedom provided by the opportunity to choose in dorsolateral striatum. PMID:23864380

  20. LET spectrum measurements in Cr-39 PNTD with AFM

    International Nuclear Information System (INIS)

    Johnson, Carl Edward; DeWitt, Joel M.; Benton, Eric R.; Yasuda, Nakahiro; Benton, Eugene V.

    2010-01-01

    Energetic protons, neutrons, and heavy ions undergoing collisions with target nuclei of varying Z can produce residual heavy recoil fragments via intra-nuclear cascade/evaporation reactions. The particles produced in these non-elastic collisions generally have such extremely short range (∼< 10 μm) that they cannot be directly observed by conventional detection methods including CR-39 plastic nuclear track detector (PNTD) that has been chemically etched for analysis by standard visible light microscopy. However, high-LET recoil fragments having range on the order of several cell diameters can be produced in tissue during radiotherapy using proton and carbon beams. We have developed a method to analyze short-range, high-LET tracks in CR-39 plastic nuclear track detector (PNTD) using short duration chemical etching (∼< 1 μm) followed by automated atomic force microscope (AFM) scanning. The post-scan data processing used in this work was based on semi-automated matrix analysis opposed to traditional grey-scale image analysis. This method takes advantage of the 3-D data obtained via AFM to achieve robust discrimination of nuclear tracks from other features. Through automation of AFM scanning, sufficient AFM scan frames were obtained to attain an LET spectrum spanning the LET range from 200-1500 keV/μm. In addition to our experiments, simulations were carried out with the Monte Carlo transport code, FLUKA. To demonstrate this method, CR-39 PNTD was exposed to the proton therapy beam at Loma Linda University Medical Center (LLUMC) at 60 and 230 MeV. Additionally, detectors were exposed to I GeV protons at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL). For these exposures CR-39 PNTD, Al and Cu target foils were used between detector layers.

  1. Forget about the future - let's get on with the past!

    DEFF Research Database (Denmark)

    McQuaid, Sara Dybris

    'Forget about the Future - Let's get on with the Past! Trails of truth recovery and provisional justice in Northern Ireland' Abstract: In Northern Ireland an agreed and comprehensive framework for ‘dealing with the past’ has yet to be worked out. In this policy vacuum a bricolage of different met...... demonstrate how initiatives conceived to serve a particular function can often transmute to serve other or additional functions with severe consequences for both the peace process and future policies for the past....

  2. LET spectrum measurements in Cr-39 PNTD with AFM

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Carl Edward [Los Alamos National Laboratory; De Witt, Joel M [OSU, PHYSICS; Benton, Eric R [OSU, PHYSICS; Yasuda, Nakahiro [NIRS, HIMAC; Benton, Eugene V [UNIV OF SAN FRANCISCO

    2010-01-01

    Energetic protons, neutrons, and heavy ions undergoing collisions with target nuclei of varying Z can produce residual heavy recoil fragments via intra-nuclear cascade/evaporation reactions. The particles produced in these non-elastic collisions generally have such extremely short range ({approx}< 10 {mu}m) that they cannot be directly observed by conventional detection methods including CR-39 plastic nuclear track detector (PNTD) that has been chemically etched for analysis by standard visible light microscopy. However, high-LET recoil fragments having range on the order of several cell diameters can be produced in tissue during radiotherapy using proton and carbon beams. We have developed a method to analyze short-range, high-LET tracks in CR-39 plastic nuclear track detector (PNTD) using short duration chemical etching ({approx}< 1 {mu}m) followed by automated atomic force microscope (AFM) scanning. The post-scan data processing used in this work was based on semi-automated matrix analysis opposed to traditional grey-scale image analysis. This method takes advantage of the 3-D data obtained via AFM to achieve robust discrimination of nuclear tracks from other features. Through automation of AFM scanning, sufficient AFM scan frames were obtained to attain an LET spectrum spanning the LET range from 200-1500 keV/{mu}m. In addition to our experiments, simulations were carried out with the Monte Carlo transport code, FLUKA. To demonstrate this method, CR-39 PNTD was exposed to the proton therapy beam at Loma Linda University Medical Center (LLUMC) at 60 and 230 MeV. Additionally, detectors were exposed to I GeV protons at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL). For these exposures CR-39 PNTD, Al and Cu target foils were used between detector layers.

  3. Let the Data Speak for Themselves: Opportunities and Caveats

    Directory of Open Access Journals (Sweden)

    Koenraad Debackere

    2016-03-01

    Full Text Available “Let the data speak for themselves” highlights the tremendous opportunities for scientific inquiry that emerge from the digital and data science revolution. It is obvious that the sophistication of novel data and information science methods offers tremendous opportunities for theory testing, theory advancement, and theory development. In order to fully capture those opportunities, it is important to avoid the slippery slope of pure induction.

  4. THE LET ME LEARN PROFESSIONAL LEARNING PROCESS FOR TEACHER TRANSFORMATION

    OpenAIRE

    Calleja, Colin

    2013-01-01

    This research set out to explore how a group of nine educators from a Catholic Church school in Malta, who have attended the Let Me Learn professional Learning process (LMLpLp), experienced personal and professional transformation. This study investigates those factors influencing participants in their transformative learning journey. It also explores the dynamics of transformative learning and whether individual transformation affects the school’s transformative learning experience. More spe...

  5. Let your communication skills equal your clinical skills.

    Science.gov (United States)

    Demarais, Ann; Baum, Neil

    2012-01-01

    Relating effectively with patients is among the most valued skills of clinical care. Honing your communication skills is an art that every physician needs to learn and understand. In this era of increased volume of patients there is a tendency to lose sight of the importance of having good communication skills. This article will review 11 suggestions for letting your communication skills equal your clinical skills.

  6. Internal high linear energy transfer (LET) targeted radiotherapy for cancer

    International Nuclear Information System (INIS)

    Allen, Barry J

    2006-01-01

    High linear energy transfer (LET) radiation for internal targeted therapy has been a long time coming on to the medical therapy scene. While fundamental principles were established many decades ago, the clinical implementation has been slow. Localized neutron capture therapy, and more recently systemic targeted alpha therapy, are at the clinical trial stage. What are the attributes of these therapies that have led a band of scientists and clinicians to dedicate so much of their careers? High LET means high energy density, causing double strand breaks in DNA, and short-range radiation, sparing adjacent normal tissues. This targeted approach complements conventional radiotherapy and chemotherapy. Such therapies fail on several fronts. Foremost is the complete lack of progress for the control of primary GBM, the holy grail for cancer therapies. Next is the inability to regress metastatic cancer on a systemic basis. This has been the task of chemotherapy, but palliation is the major application. Finally, there is the inability to inhibit the development of lethal metastatic cancer after successful treatment of the primary cancer. This review charts, from an Australian perspective, the developing role of local and systemic high LET, internal radiation therapy. (review)

  7. Reflecting on the challenges of choosing and using a grounded theory approach.

    Science.gov (United States)

    Markey, Kathleen; Tilki, Mary; Taylor, Georgina

    2014-11-01

    To explore three different approaches to grounded theory and consider some of the possible philosophical assumptions underpinning them. Grounded theory is a comprehensive yet complex methodology that offers a procedural structure that guides the researcher. However, divergent approaches to grounded theory present dilemmas for novice researchers seeking to choose a suitable research method. This is a methodology paper. This is a reflexive paper that explores some of the challenges experienced by a PhD student when choosing and operationalising a grounded theory approach. Before embarking on a study, novice grounded theory researchers should examine their research beliefs to assist them in selecting the most suitable approach. This requires an insight into the approaches' philosophical assumptions, such as those pertaining to ontology and epistemology. Researchers need to be clear about the philosophical assumptions underpinning their studies and the effects that different approaches will have on the research results. This paper presents a personal account of the journey of a novice grounded theory researcher who chose a grounded theory approach and worked within its theoretical parameters. Novice grounded theory researchers need to understand the different philosophical assumptions that influence the various grounded theory approaches, before choosing one particular approach.

  8. The who, what, when, and how of choosing a dietetics career.

    Science.gov (United States)

    Lordly, Daphne; Dubé, Nicole

    2012-01-01

    We describe factors influencing the career choices of students enrolled in Canadian dietetics programs. A survey was administered, in class or online, to core first- and fourth-year classes in seven dietetics programs in various provinces (n=397). Data were analyzed with the use of descriptive statistics. Chi-square testing for independence established significant relationships. Students ranked personal satisfaction, job security, and a professional career as important general career outcomes. These factors were also perceived to be attainable through a dietetics career. The majority of students chose dietetics while they were enrolled in a post-secondary degree program (44%), were primarily influenced by family members (54%), and based their choice on information acquired through the media (50%). Motivations for choosing dietetics included an interest in nutrition (91%) and health (90%), and a desire to help others (82%). Younger students placed more importance on economic rewards and having a position of authority than did older students. Older students identified personal satisfaction as more important in career selection than did younger students. Female respondents placed higher value on job flexibility than did their male counterparts. Career choice is based on a variety of internal and external factors. Opportunities exist for strategic recruitment efforts by educators and the profession.

  9. Harderian Gland Tumorigenesis: Low-Dose and LET Response

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Polly Y. [SRI International, Menlo Park, CA (United States). Biosciences Div.; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Cucinotta, Francis A. [Univ. of Nevada, Las Vegas, NV (United States). Dept. of Health Physics and Diagnostic Sciences; Bjornstad, Kathleen A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Bakke, James [SRI International, Menlo Park, CA (United States). Biosciences Div.; Rosen, Chris J. [SRI International, Menlo Park, CA (United States). Biosciences Div.; Du, Nicholas [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Fairchild, David G. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Cacao, Eliedonna [Univ. of Nevada, Las Vegas, NV (United States). Dept. of Health Physics and Diagnostic Sciences; Blakely, Eleanor A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.

    2016-04-19

    Increased cancer risk remains a primary concern for travel into deep space and may preclude manned missions to Mars due to large uncertainties that currently exist in estimating cancer risk from the spectrum of radiations found in space with the very limited available human epidemiological radiation-induced cancer data. Existing data on human risk of cancer from X-ray and gamma-ray exposure must be scaled to the many types and fluences of radiations found in space using radiation quality factors and dose-rate modification factors, and assuming linearity of response since the shapes of the dose responses at low doses below 100 mSv are unknown. The goal of this work was to reduce uncertainties in the relative biological effect (RBE) and linear energy transfer (LET) relationship for space-relevant doses of charged-particle radiation-induced carcinogenesis. The historical data from the studies of Fry et al. and Alpen et al. for Harderian gland (HG) tumors in the female CB6F1 strain of mouse represent the most complete set of experimental observations, including dose dependence, available on a specific radiation-induced tumor in an experimental animal using heavy ion beams that are found in the cosmic radiation spectrum. However, these data lack complete information on low-dose responses below 0.1 Gy, and for chronic low-dose-rate exposures, and there are gaps in the LET region between 25 and 190 keV/μm. In this study, we used the historical HG tumorigenesis data as reference, and obtained HG tumor data for 260 MeV/u silicon (LET ~70 keV/μm) and 1,000 MeV/u titanium (LET ~100 keV/μm) to fill existing gaps of data in this LET range to improve our understanding of the dose-response curve at low doses, to test for deviations from linearity and to provide RBE estimates. Animals were also exposed to five daily fractions of 0.026 or 0.052 Gy of 1,000 MeV/u titanium ions to simulate chronic exposure, and HG tumorigenesis from this fractionated study were compared to the

  10. Circulating East to East: Understanding the Push-Pull Factors of Chinese Students Studying in Korea

    Science.gov (United States)

    Lee, Se Woong

    2017-01-01

    Every year, substantial numbers of students choose to study abroad, and China is one of the largest exporters of international students. Interestingly, instead of choosing English-speaking countries, increasingly more Chinese students are choosing nearby Asian countries as their destination to study abroad, particularly Korea. Despite this…

  11. Consumer preference not to choose: Methodological and policy implications

    International Nuclear Information System (INIS)

    Brennan, Timothy J.

    2007-01-01

    Residential consumers remain reluctant to choose new electricity suppliers. Even the most successful jurisdictions, four US states and other countries, have had to adopt extensive consumer education procedures that serve largely to confirm that choosing electricity suppliers is daunting. Electricity is not unique in this respect; numerous studies find that consumers are generally reluctant to switch brands, even when they are well-informed about product characteristics. If consumers prefer not to choose, opening regulated markets can reduce welfare, even for some consumers who do switch, as the incumbent can exploit this preference by raising price above the formerly regulated level. Policies to open markets might be successful even if limited to industrial and commercial customers, with residential prices based on those in nominally competitive wholesale markets

  12. Choosing a New Telephone System for Your Medical Practice.

    Science.gov (United States)

    Metherell, Brian

    2016-01-01

    E-mail may rule the world in other types of businesses, but for medical practices, the telephone remains the primary mode of communication with patients, specialists, and pharmacies. From making appointments to calling in prescriptions, telephones are essential to patient care. With technology changing very quickly and new capabilities coming into the medical practice, such as telemedicine and Skype, you need to know your options when choosing a new telephone system. The possibilities include on-site, cloud, and hybrid networked solutions. A wide variety of features and capabilities are available, from dozens of vendors. Of course, no matter what telephone solution you choose, you must meet regulatory compliance, particularly HIPAA, and Payment Card Industry Data Security Standard if you take credit cards. And it has to be affordable, reliable, and long lasting. This article explores what medical practices need to know when choosing a new business telephone system in order to find the right solutions for their businesses.

  13. Sport, how people choose it: A network analysis approach.

    Science.gov (United States)

    Ferreri, Luca; Ivaldi, Marco; Daolio, Fabio; Giacobini, Mario; Rainoldi, Alberto; Tomassini, Marco

    2015-01-01

    In order to investigate the behaviour of athletes in choosing sports, we analyse data from part of the We-Sport database, a vertical social network that links athletes through sports. In particular, we explore connections between people sharing common sports and the role of age and gender by applying "network science" approaches and methods. The results show a disassortative tendency of athletes in choosing sports, a negative correlation between age and number of chosen sports and a positive correlation between age of connected athletes. Some interesting patterns of connection between age classes are depicted. In addition, we propose a method to classify sports, based on the analyses of the behaviour of people practising them. Thanks to this brand new classifications, we highlight the links of class of sports and their unexpected features. We emphasise some gender dependency affinity in choosing sport classes.

  14. Precise let-7 expression levels balance organ regeneration against tumor suppression

    Science.gov (United States)

    Wu, Linwei; Nguyen, Liem H; Zhou, Kejin; de Soysa, T Yvanka; Li, Lin; Miller, Jason B; Tian, Jianmin; Locker, Joseph; Zhang, Shuyuan; Shinoda, Gen; Seligson, Marc T; Zeitels, Lauren R; Acharya, Asha; Wang, Sam C; Mendell, Joshua T; He, Xiaoshun; Nishino, Jinsuke; Morrison, Sean J; Siegwart, Daniel J; Daley, George Q; Shyh-Chang, Ng; Zhu, Hao

    2015-01-01

    The in vivo roles for even the most intensely studied microRNAs remain poorly defined. Here, analysis of mouse models revealed that let-7, a large and ancient microRNA family, performs tumor suppressive roles at the expense of regeneration. Too little or too much let-7 resulted in compromised protection against cancer or tissue damage, respectively. Modest let-7 overexpression abrogated MYC-driven liver cancer by antagonizing multiple let-7 sensitive oncogenes. However, the same level of overexpression blocked liver regeneration, while let-7 deletion enhanced it, demonstrating that distinct let-7 levels can mediate desirable phenotypes. let-7 dependent regeneration phenotypes resulted from influences on the insulin-PI3K-mTOR pathway. We found that chronic high-dose let-7 overexpression caused liver damage and degeneration, paradoxically leading to tumorigenesis. These dose-dependent roles for let-7 in tissue repair and tumorigenesis rationalize the tight regulation of this microRNA in development, and have important implications for let-7 based therapeutics. DOI: http://dx.doi.org/10.7554/eLife.09431.001 PMID:26445246

  15. High energy ion irradiation effects on polymer materials. LET dependence of G value of scission of polymethylmethacrylate (PMMA)

    Energy Technology Data Exchange (ETDEWEB)

    Kudoh, H; Sasuga, T; Seguchi, T [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1997-03-01

    Linear energy transfer (LET) dependence on the probability of main chain scission of polymethylmethacrylate (PMMA) was investigated. The probability was obtained from decreases in molecular weight measured by the gel permeation chromatography (GPC), and LET was evaluated by TRIM code. The scission probability as a function of LET was almost constant in the low LET, and decreased in the high LET ion irradiation. The mechanism was interpreted from the model of spur-overlapping along an ion`s path. (author)

  16. Why Do Women Choose to Enter Academic Oral and Maxillofacial Surgery?

    Science.gov (United States)

    Kolokythas, Antonia; Miloro, Michael

    2016-05-01

    To determine why women choose to enter an academic career in oral and maxillofacial surgery (OMS). An online questionnaire was developed and e-mailed to female OMS surgeons to assess the reasons women choose to pursue an academic career, the perceived positive and negative features of academia for women, and proposed measures to increase the percentage of women choosing to specialize in OMS and pursue an academic career. Thirty-one female OMS surgeons completed the questionnaire; 1 additional participant accessed the survey but did not respond to any of the questions. There were 25 full-time academics and 6 part-time academics (≥50% time commitment). Of the responders, 72% were married, and of these, 72% were married before entering academics. Forty-seven percent of the women had children, all during their academic tenure. Among the full-time academicians with children, only 2 (7.7%) reported moderate difficulty finding the time for childbirth and maternity leave, whereas 3 of the 5 part-time academics with children reported moderate or significant difficulty with childbirth and maternity leave. Factors associated with choosing and enjoying an academic career are involvement in resident-student teaching (78%), followed by colleague camaraderie and collaboration (65.6%), research potential (50%), time flexibility, and not having to deal with excessive "business" practice issues (33%). The main reason for considering leaving an academic OMS career and/or among the least enjoyable aspects of being in academics was the potential for a higher income in private practice (56%). Less significant reasons for considering leaving an academic OMS career were a more flexible work schedule in the private sector and less institutional red tape (37.5%), as well as independence/being in control and more family time (22%). Engaging residents and students by female OMS surgeons, better mentorship from academic OMS surgeons, and increasing the number of women serving in leadership

  17. Choosing the negative: A behavioral demonstration of morbid curiosity

    NARCIS (Netherlands)

    Oosterwijk, S.

    2017-01-01

    This paper examined, with a behavioral paradigm, to what extent people choose to view stimuli that portray death, violence or harm. Based on briefly presented visual cues, participants made choices between highly arousing, negative images and positive or negative alternatives. The negative images

  18. Choosing the Future You Prefer. A Goal Setting Guide.

    Science.gov (United States)

    Lindaman, Edward B.; Lippitt, Ronald O.

    The guide, intended for group and organization leaders, presents activities and exercises to aid in personal and group goal-setting and planning for the future. The objective is to help groups choose goals which are sensitive to and oriented toward the evolving future with its rapid rate of change. The guide is presented in eight chapters.…

  19. Choosing of optimal start approximation for laplace equation ...

    African Journals Online (AJOL)

    We investigate Dirichlet problem for a case of two-dimensional area with lime border, numerical scheme for solving this equation is widely knowns it finite difference method. One of the major stages in the algorithm for that numerical solution is choosing of start approximation, usually as the initial values of the unknown ...

  20. Choosing the Right Assessment for the Right Purpose

    Science.gov (United States)

    Eliasson, Ann-Christin

    2012-01-01

    Assessments used for both clinical practice and research should show evidence of validity and reliability for the target group of people. It is easy to agree with this statement, but it is not always easy to choose the right assessment for the right purpose. Recently there have been increasing numbers of studies which investigate further the…

  1. The Dilemma of Individual Autonomy versus Choosing Rightly

    Science.gov (United States)

    Yehezkely, Chen

    2015-01-01

    Many important goals or values of education are tokens of either one of these two meta-goals-values: raising our children to be autonomous, or raising them to choose rightly. Thus, the conflicts between many educational goals-values are tokens of the meta-conflict between these two, and the questions of priority that such conflicts invite are…

  2. Why Do Patients Choose to Consult Homeopaths? | McIntosh ...

    African Journals Online (AJOL)

    Background: Patients are using homeopathy in increasing numbers and not telling their doctors about it. It is important as family physicians that we understand the reasons why patients choose to consult homeopaths. It is important to know what our patients are looking for that they do not find in Western medicine.

  3. Choosing early pregnancy termination methods in Urban Mozambique

    NARCIS (Netherlands)

    Mitchell, Ellen M. H.; Kwizera, Amata; Usta, Momade; Gebreselassie, Hailemichael

    2010-01-01

    Little is known about who chooses medication abortion with misoprostol and why. Women seeking early abortion in 5 public hospitals in Maputo, Mozambique were recruited in 2005 and 2006 to explore decision-making strategies, method preferences and experiences with misoprostol and vacuum aspiration

  4. Choosing the right career: What approach? Implications for career ...

    African Journals Online (AJOL)

    The presentation made here accepts the thesis that the choice of career is not a simple matter. In fact, it asserts that more than ever before, the choice of a career on a training programme now requires a lot of thinking as well as taking into consideration several factors before choosing, planning and entering into a particular ...

  5. Picking and Choosing the ‘Sovereign’Border

    DEFF Research Database (Denmark)

    Parker, Noel; Adler-Nissen, Rebecca

    2012-01-01

    We argue that the continued persistence of borders is an effect of their constitutive role for the many dimensions of a social particular. States cannot choose to have a border; but they can and do make choices amongst the materials available on the various planes of inscription for bordering. Fo...

  6. Choosing the Best Enzyme Complex Structure Made Easy.

    Science.gov (United States)

    Das, Sayoni; Orengo, Christine

    2018-04-03

    In this issue of Structure, Tyzack et al. (2018) present a study of enzyme-ligand complexes in the PDB and show that the molecular similarity of bound and cognate ligands can be used to choose the most biologically appropriate complex structure for analysis when multiple structures are available. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. More Young Black Men Choosing Not to Go to College.

    Science.gov (United States)

    Collison, Michele N-K

    1987-01-01

    More and more young Black males are choosing to enlist in the military, attend vocational and technical schools, or take jobs instead of going to college. Many yield to peer pressure and stop studying; further, role models do not exist for young Black men. (MLW)

  8. Step 7: Choose the "Best" Risk Management Alternative

    Science.gov (United States)

    The ultimate purpose of the SRM tactical phase is to choose how to manage risk. Prior to this stage, we determined the sources of risk, identified the relevant management actions and estimated the likelihood of all known outcomes. Next, we combine this information with your personal risk preference...

  9. Protein-directed modulation of high-LET hyperthermic radiosensitization

    International Nuclear Information System (INIS)

    Chang, P.Y.

    1991-01-01

    A pair of Chinese Hamster Ovary cell lines, the wild-type CHO-SC1, and its temperature-sensitive mutant (CHO-tsH1) was used to examine the importance of protein synthesis in the development of thermotolerance. The classical biphasic thermotolerant survival response to hyperthermia was observed in the SC1 cells after continuous heating at 41.5C to 42.5C, while tsH1 showed no thermotolerance. In separate experiments, each cell line was triggered and challenged at 45C. The heat doses were separated with graded incubaton periods at 35C or 40C for thermotolerance development. SC1 cells expressed thermoresistance, with the synthesis of heat shock proteins, under both incubation conditions. tsH1 cells expressed thermotolerance similar to that seen in the SC1 cells when incubated at 35C, but the survival response with the non-permissive 40C incubation was much reduced in the absence of protein synthesis. The combined effects of heavy-ion radiation and hyperthermia were examined using the same cell system. A mild heat dose of 41.5C was used in conjunction with Neon particle radiation of various high LET values. The cell killing effects were highly dependent on the sequence of application of heat and Neon radiation. Heat applied immediately after Neon irradiation was more cytotoxic to SC1 cells than when heat was applied prior to the irradiation. The ability of cells to synthesize new proteins plays a key role in this sequence-dependent thermal radiosensitization. In the absence of protein synthesis in the tsH1 cells, the high-LET thermal enhancement for cell-killing was unchanged regardless of the sequence. In the presence of protein synthetic activity in the SC1 cells, the thermal enhancement of radiation-induced cell killing was LET-dependent

  10. Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness

    International Nuclear Information System (INIS)

    Schmid, T E; Zlobinskaya, O; Michalski, D; Molls, M; Multhoff, G; Greubel, C; Hable, V; Girst, S; Siebenwirth, C; Dollinger, G; Schmid, E

    2012-01-01

    This study shows that enhanced radiobiological effectiveness (RBE) values can be generated focusing low linear energy transfer (LET) radiation and thus changing the microdose distribution. 20 MeV protons (LET = 2.65 keV µm −1 ) are focused to submicrometer diameter at the ion microprobe superconducting nanoprobe for applied nuclear (Kern) physics experiments of the Munich tandem accelerator. The RBE values, as determined by measuring micronuclei (RBE MN = 1.48 ± 0.07) and dicentrics (RBE D = 1.92 ± 0.15), in human–hamster hybrid (A L ) cells are significantly higher when 117 protons were focused to a submicrometer irradiation field within a 5.4 × 5.4 µm 2 matrix compared to quasi homogeneous in a 1 × 1 µm 2 matrix applied protons (RBE MN = 1.28 ± 0.07; RBE D = 1.41 ± 0.14) at the same average dose of 1.7 Gy. The RBE values are normalized to standard 70 kV (dicentrics) or 200 kV (micronuclei) x-ray irradiation. The 117 protons applied per point deposit the same amount of energy like a 12 C ion with 55 MeV total energy (4.48 MeV u −1 ). The enhancements are about half of that obtained for 12 C ions (RBE MN = 2.20 ± 0.06 and RBE D = 3.21 ± 0.10) and they are attributed to intertrack interactions of the induced damages. The measured RBE values show differences from predictions of the local effect model (LEM III) that is used to calculate RBE values for irradiation plans to treat tumors with high LET particles. (paper)

  11. Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness

    Science.gov (United States)

    Schmid, T. E.; Greubel, C.; Hable, V.; Zlobinskaya, O.; Michalski, D.; Girst, S.; Siebenwirth, C.; Schmid, E.; Molls, M.; Multhoff, G.; Dollinger, G.

    2012-10-01

    This study shows that enhanced radiobiological effectiveness (RBE) values can be generated focusing low linear energy transfer (LET) radiation and thus changing the microdose distribution. 20 MeV protons (LET = 2.65 keV µm-1) are focused to submicrometer diameter at the ion microprobe superconducting nanoprobe for applied nuclear (Kern) physics experiments of the Munich tandem accelerator. The RBE values, as determined by measuring micronuclei (RBEMN = 1.48 ± 0.07) and dicentrics (RBED = 1.92 ± 0.15), in human-hamster hybrid (AL) cells are significantly higher when 117 protons were focused to a submicrometer irradiation field within a 5.4 × 5.4 µm2 matrix compared to quasi homogeneous in a 1 × 1 µm2 matrix applied protons (RBEMN = 1.28 ± 0.07; RBED = 1.41 ± 0.14) at the same average dose of 1.7 Gy. The RBE values are normalized to standard 70 kV (dicentrics) or 200 kV (micronuclei) x-ray irradiation. The 117 protons applied per point deposit the same amount of energy like a 12C ion with 55 MeV total energy (4.48 MeV u-1). The enhancements are about half of that obtained for 12C ions (RBEMN = 2.20 ± 0.06 and RBED = 3.21 ± 0.10) and they are attributed to intertrack interactions of the induced damages. The measured RBE values show differences from predictions of the local effect model (LEM III) that is used to calculate RBE values for irradiation plans to treat tumors with high LET particles.

  12. Microdosimetric spectra and parameters of low LET-radiations

    International Nuclear Information System (INIS)

    Booz, J.

    1976-01-01

    The experimental methods used for the evaluation of the flux averaged lineal energy y and the energy averaged lineal energy ysub(D) are briefly described. The composition of the y-distribution of low LET-radiations are discussed taking into consideration the energy of the electrons causing the event and the influence of their W-values. Some published values of ysub(F) and ysub(D) and their relation to the dimensions of the sensitive volume are analyzed. The wall effect is briefly discussed

  13. Choosing Fighting Competitors Among Men: Testosterone, Personality, and Motivations.

    Science.gov (United States)

    Borráz-León, Javier I; Cerda-Molina, Ana Lilia; Rantala, Markus J; Mayagoitia-Novales, Lilian

    2018-01-01

    Higher testosterone levels have been positively related to a variety of social behaviors and personality traits associated with intrasexual competition. The aim of this study was to evaluate the role of testosterone levels and personality traits such as aggressiveness, competitiveness, and self-esteem on the task of choosing a fighting competitor (a rival) with or without a motivation to fight. In Study 1, a group of 119 men participated in a task for choosing a rival through pictures of men with high-dominant masculinity versus low-dominant masculinity. Participants completed three personality questionnaires and donated two saliva samples (pre-test and post-test sample) to quantify their testosterone levels. We found that the probability of choosing high-dominant masculine men as rivals increased with higher aggressiveness scores. In Study 2, the task of choosing rivals was accompanied by motivations to fight (pictures of women with high or low waist-to-hip ratio [WHR]). In this context, we observed that the probability of choosing dominant masculine men as rivals depended on the WHR of the women. Overall, average levels of post-test testosterone, aggressiveness, and high self-esteem increased the probability to fight for women with low WHR independently of the dominance masculinity of the rivals. Our results indicate that human decisions, in the context of intrasexual competition and mate choice, are regulated by physiological and psychological mechanisms allowing men to increase their biological fitness. We discuss our results in the light of the plasticity of human behavior according to biological and environmental forces.

  14. Mutagenic action of radiation with different LET on Bacillus subtilis cells

    International Nuclear Information System (INIS)

    edinennyj Inst. Yadernykh Issledovanij, Dubna (Russian Federation))" data-affiliation=" (Obedinennyj Inst. Yadernykh Issledovanij, Dubna (Russian Federation))" >Borejko, A.V.; edinennyj Inst. Yadernykh Issledovanij, Dubna (Russian Federation))" data-affiliation=" (Obedinennyj Inst. Yadernykh Issledovanij, Dubna (Russian Federation))" >Krasavin, E.A.

    1997-01-01

    The induction of the his - -> his + mutants in vegetative and spores of Bacillus subtilis wild type cells irradiated with γ-rays and helium ions (LET = 20-80 keV/μm) has been investigated. It was shown that the dose dependence of the mutation induction in vegetative cells is described by a linear-quadratic function of dose in case of both γ-rays and helium ions. RBE (LET) dependencies on the lethal and mutagenic effect of radiation have a local maximum. The maximum of RBE (LET) dependence on the mutagenic assay is shifted at the low region of LET in comparison with the lethal effect of irradiation. (author)

  15. The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.

    Science.gov (United States)

    McDaniel, Kelly; Huang, Li; Sato, Keisaku; Wu, Nan; Annable, Tami; Zhou, Tianhao; Ramos-Lorenzo, Sugeily; Wan, Ying; Huang, Qiaobing; Francis, Heather; Glaser, Shannon; Tsukamoto, Hidekazu; Alpini, Gianfranco; Meng, Fanyin

    2017-07-07

    The let-7/Lin28 axis is associated with the regulation of key cellular regulatory genes known as microRNAs in various human disorders and cancer development. This study evaluated the role of the let-7/Lin28 axis in regulating a mesenchymal phenotype of hepatic stellate cells in alcoholic liver injury. We identified that ethanol feeding significantly down-regulated several members of the let-7 family in mouse liver, including let-7a and let-7b. Similarly, the treatment of human hepatic stellate cells (HSCs) with lipopolysaccharide (LPS) and transforming growth factor-β (TGF-β) significantly decreased the expressions of let-7a and let-7b. Conversely, overexpression of let-7a and let-7b suppressed the myofibroblastic activation of cultured human HSCs induced by LPS and TGF-β, as evidenced by repressed ACTA2 (α-actin 2), COL1A1 (collagen 1A1), TIMP1 (TIMP metallopeptidase inhibitor 1), and FN1 (fibronectin 1); this supports the notion that HSC activation is controlled by let-7. A combination of bioinformatics, dual-luciferase reporter assay, and Western blot analysis revealed that Lin28B and high-mobility group AT-hook (HMGA2) were the direct targets of let-7a and let-7b. Furthermore, Lin28B deficiency increased the expression of let-7a/let-7b as well as reduced HSC activation and liver fibrosis in mice with alcoholic liver injury. This feedback regulation of let-7 by Lin28B is verified in hepatic stellate cells isolated by laser capture microdissection from the model. The identification of the let-7/Lin28 axis as an important regulator of HSC activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis and novel therapeutic approaches for human alcoholic liver diseases. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  16. Future Directions for The Math You Need, When You Need It: Adaptation and Implementation of Online Student-Centered Tutorials that Remediate Introductory Geoscience-Related Mathematical Skills

    Science.gov (United States)

    Wenner, J. M.; Burn, H.; Baer, E. M.

    2009-12-01

    Requiring introductory geoscience students to apply mathematical concepts and solve quantitative problems can be an arduous task because these courses tend to attract students with diverse levels of mathematical preparedness. Perhaps more significantly, geoscience instructors grapple with quantitative content because of the difficulties students have transferring their prior mathematical learning to common geological problems. As a result, instructors can choose to eliminate the mathematics, spend valuable class time teaching basic mathematical skills or let students flounder in the hope that they will learn on their own. None of these choices are ideal. Instead, research suggests that introductory geoscience courses are opportune places to increase students’ quantitative abilities but that students need effective support at their own skill level. To provide such support, we developed The Math You Need, When You Need It (TMYN): a set of online geoscience context-rich tutorials that students complete just before they encounter a mathematical or numerical skill in their introductory course. The tutorials are modular; each mathematical topic has a set of pages that students work through toward a final assessment. The 11 modules currently available, including unit conversions, graphing, calculating density, and rearranging equations, touch on quantitative topics that cross a number of geologic contexts. TMYN modules are designed to be stand-alone and flexible - faculty members can choose modules appropriate for their courses and implement them at any time throughout the term. The flexible and adaptable nature of TMYN enables faculty to provide a supportive learning environment that remediates math for those who need it without taking significant classroom time. Since spring 2008, seven instructors at Highline Community College and University of Wisconsin Oshkosh successfully implemented TMYN in six geoscience courses with diverse student audiences. Evaluation of

  17. Factors determinating the shape of survival curves of Escherichia coli cells irradiated by ionizing radiation with different LET. The dependence of the shape of survival curve on LET

    International Nuclear Information System (INIS)

    Kozubek, S.; Krasavin, E.A.; Fajsi, Ch.

    1984-01-01

    The dependence of the shape of bacterial sUrvival curve in the case of Escherichia coli Wild type, rec - and pol - mutants on linear energy transfer is considered. When increasing LET of the radiation the shouldered survival curves are transformed to exponential ones. In the case of sensitive mutants the transformation is observed for smaller values of LET. The dependence of cell sensitivity on LET calculated on the basis of Landau-Vavilov distribution is compared with earlier calculations. The comparison showed a good agreement between two methods of calculation for ions with 4 MeV per nucleon energy

  18. First-Year Female Students: Perceptions of Friendship.

    Science.gov (United States)

    Ishler, Jennifer L. Crissman; Schreiber, Staci

    2002-01-01

    Examined 91 first-year female students' perceptions of their pre-college and new collegiate friendships. Found that they have difficulty letting go of pre-college friendships and investing in new friendships. (EV)

  19. Polarisation analysis on the LET time-of-flight spectrometer

    Science.gov (United States)

    Nilsen, G. J.; Košata, J.; Devonport, M.; Galsworthy, P.; Bewley, R. I.; Voneshen, D. J.; Dalgliesh, R.; Stewart, J. R.

    2017-06-01

    We present a design for implementing uniaxial polarisation analysis on the LET cold neutron time-of-flight spectrometer, installed on the second target station at ISIS. The polarised neutron beam is to be produced by a transmission-based supermirror polariser with the polarising mirrors arranged in a “double-V” formation. This will be followed by a Mezei-type precession coil spin flipper, selected for its small spatial requirements, as well as a permanent magnet guide field to transport the beam polarisation to the sample position. The sample area will contain a set of holding field coils, whose purpose is to produce a highly homogenous magnetic field for the wide-angle 3He analyser cell. To facilitate fast cell changes and reduce the risk of cell failure, we intend to separate the cell and cryostat from the vacuum of the sample tank by installing both in a vessel at atmospheric pressure. When the instrument upgrade is complete, the performance of LET is expected to be commensurate with existing and planned polarised cold neutron spectrometers at other sources. Finally, we discuss the implications of performing uniaxial polarisation analysis only, and identify quasi-elastic neutron scattering (QENS) on ionic conducting materials as an interesting area to apply the technique.

  20. Calculated LET spectrum from antiproton beams stopping in water

    CERN Document Server

    Bassler, Niels

    2009-01-01

    Antiprotons have been proposed as a potential modality for radiotherapy because the annihilation at the end of range leads to roughly a doubling of physical dose in the Bragg peak region. So far it has been anticipated that the radiobiology of antiproton beams is similar to that of protons in the entry region of the beam, but very different in the annihilation region, due to the expected high-LET components resulting from the annihilation. On closer inspection we find that calculations of dose averaged LET in the entry region may suggest that the RBE of antiprotons in the plateau region could significantly differ from unity, which seems to warrant closer inspection of the radiobiology in this region. Materials and Methods. Monte Carlo simulations using FLUKA were performed for calculating the entire particle spectrum of a beam of 126 MeV antiprotons hitting a water phantom. Results and Discussion. In the plateau region of the simulated antiproton beam we observe a dose-averaged unrestrict...

  1. Let's Go to the Zoo: Guiding Elementary Students through Research; Ladders of Collaboration; Information Literacy and Assessment: Web Resources Too Good To Miss; Top Secret: Collaborative Efforts Really Do Make a Difference; What Is Collaboration to You?; Volunteering for Information Literacy; Getting an Early Start on Using Technology for Research; Collaborations: Working with Restrictions.

    Science.gov (United States)

    Futch, Lynn; Asper, Vicki; Repman, Judi; Tschamler, Addie; Thomas, Melody; Kearns, Jodi; Farmer, Lesley S. J.; Buzzeo, Toni

    2002-01-01

    Includes eight articles that address the role of the elementary school librarian in developing information literacy, focusing on collaboration between media specialists and classroom teachers. Highlights include student research, including a research planning sheet; Web resources on information literacy and assessment; and helping students use…

  2. MicroRNA let-7, T cells, and patient survival in colorectal cancer

    Science.gov (United States)

    Dou, Ruoxu; Nishihara, Reiko; Cao, Yin; Hamada, Tsuyoshi; Mima, Kosuke; Masuda, Atsuhiro; Masugi, Yohei; Shi, Yan; Gu, Mancang; Li, Wanwan; da Silva, Annacarolina; Nosho, Katsuhiko; Zhang, Xuehong; Meyerhardt, Jeffrey A.; Giovannucci, Edward L.; Chan, Andrew T.; Fuchs, Charles S.; Qian, Zhi Rong; Ogino, Shuji

    2016-01-01

    Experimental evidence suggests that the let-7 family of noncoding RNAs suppresses adaptive immune responses, contributing to immune evasion by the tumor. We hypothesized that the amount of let-7a and let-7b expression in colorectal carcinoma might be associated with limited T-lymphocyte infiltrates in the tumor microenvironment and worse clinical outcome. Utilizing the molecular pathological epidemiology resources of 795 rectal and colon cancers in two U.S.-nationwide prospective cohort studies, we measured tumor-associated let-7a and let-7b expression levels by quantitative reverse-transcription PCR, and CD3+, CD8+, CD45RO (PTPRC)+, and FOXP3+ cell densities by tumor tissue microarray immunohistochemistry and computer-assisted image analysis. Logistic regression analysis and Cox proportional hazards regression were used to assess associations of let-7a (and let-7b) expression (quartile predictor variables) with T-cell densities (binary outcome variables) and mortality, respectively, controlling for tumor molecular features, including microsatellite instability, CpG island methylator phenotype, LINE-1 methylation, and KRAS, BRAF, and PIK3CA mutations. Compared with cases in the lowest quartile of let-7a expression, those in the highest quartile were associated with lower densities of CD3+ [multivariate odds ratio (OR), 0.40; 95% confidence interval (CI), 0.23 to 0.67; Ptrend = 0.003] and CD45RO+ cells (multivariate OR, 0.31; 95% CI, 0.17 to 0.58; Ptrend = 0.0004), and higher colorectal cancer-specific mortality (multivariate hazard ratio, 1.82; 95% CI, 1.42 to 3.13; Ptrend = 0.001). In contrast, let-7b expression was not significantly associated with T-cell density or colorectal cancer prognosis. Our data support the role of let-7a in suppressing antitumor immunity in colorectal cancer, and suggest let-7a as a potential target of immunotherapy. PMID:27737877

  3. High and Low LET Radiation Differentially Induce Normal Tissue Damage Signals

    International Nuclear Information System (INIS)

    Niemantsverdriet, Maarten; Goethem, Marc-Jan van; Bron, Reinier; Hogewerf, Wytse; Brandenburg, Sytze; Langendijk, Johannes A.; Luijk, Peter van; Coppes, Robert P.

    2012-01-01

    Purpose: Radiotherapy using high linear energy transfer (LET) radiation is aimed at efficiently killing tumor cells while minimizing dose (biological effective) to normal tissues to prevent toxicity. It is well established that high LET radiation results in lower cell survival per absorbed dose than low LET radiation. However, whether various mechanisms involved in the development of normal tissue damage may be regulated differentially is not known. Therefore the aim of this study was to investigate whether two actions related to normal tissue toxicity, p53-induced apoptosis and expression of the profibrotic gene PAI-1 (plasminogen activator inhibitor 1), are differentially induced by high and low LET radiation. Methods and Materials: Cells were irradiated with high LET carbon ions or low LET photons. Cell survival assays were performed, profibrotic PAI-1 expression was monitored by quantitative polymerase chain reaction, and apoptosis was assayed by annexin V staining. Activation of p53 by phosphorylation at serine 315 and serine 37 was monitored by Western blotting. Transfections of plasmids expressing p53 mutated at serines 315 and 37 were used to test the requirement of these residues for apoptosis and expression of PAI-1. Results: As expected, cell survival was lower and induction of apoptosis was higher in high -LET irradiated cells. Interestingly, induction of the profibrotic PAI-1 gene was similar with high and low LET radiation. In agreement with this finding, phosphorylation of p53 at serine 315 involved in PAI-1 expression was similar with high and low LET radiation, whereas phosphorylation of p53 at serine 37, involved in apoptosis induction, was much higher after high LET irradiation. Conclusions: Our results indicate that diverse mechanisms involved in the development of normal tissue damage may be differentially affected by high and low LET radiation. This may have consequences for the development and manifestation of normal tissue damage.

  4. Choosing the Path of Leadership in Occupational Therapy

    Directory of Open Access Journals (Sweden)

    Clark Patrick Heard D.OT Reg. (Ont.

    2014-01-01

    Full Text Available Leadership is vital to the success and sustainability of any group, organization, or profession. Using a qualitative phenomenological methodology, consistent with interpretative phenomenological analysis, this study examines why occupational therapists choose the path of leadership. Data was collected through the completion of semistructured interviews with 10 occupational therapy leaders in Ontario, Canada. This collected data was transcribed verbatim and coded for themes by multiple coders. Several methods were employed to establish trustworthiness. Results identify that a desire to influence the profession or care delivery, a need for personal or career development, and a need for change motivate those occupational therapists who might choose the path of leadership. Recommendations for supporting new or developing leaders include a focus on linking occupational therapy practice and leadership theory at the curriculum and professional levels. Moreover, application of novel approaches to mentorship for new and developing leaders, such as supportive communities of practice, are also considered.

  5. Choosing how to feel: emotion regulation choice in bipolar disorder.

    Science.gov (United States)

    Hay, Aleena C; Sheppes, Gal; Gross, James J; Gruber, June

    2015-04-01

    Individuals with bipolar disorder experience emotion regulation difficulties, even during remission, but are able to effectively employ emotion regulation strategies when instructed. We hypothesized that this puzzling discrepancy might be due to their maladaptive emotion regulation choices. To test this hypothesis, we used a previously validated paradigm (Sheppes, Scheibe, Suri, & Gross, 2011; Sheppes et al., 2014), and asked remitted individuals with bipolar I disorder (n = 25) and healthy individuals (n = 26) to view standardized positive and negative images of high and low intensity, and choose reappraisal or distraction to decrease their emotion intensity. Replicating and extending prior results, participants across both groups showed a pattern of choosing distraction more for high versus low intensity positive and negative images, but no between-groups differences were evident. These results suggest that emotion regulation choice patterns may be robust across samples, and add to growing evidence that several basic emotion regulation elements may remain intact in bipolar disorder. (c) 2015 APA, all rights reserved).

  6. CHOOSING THE POWER OF TRACTION ELECTRIC MOTORS FOR ELECTRIC VEHICLES

    OpenAIRE

    O. Smirnov; A. Borisenko

    2017-01-01

    Recommendations on choosing the power of the electric motor, depending on the weight of the vehicle, its speed and the run distance in the «only electricity» mode are developed. Based on mathematical modeling and a number of field tests of electric vehicles, a three-dimensional dependance of the power on the weight and the speed set is built and conclusions are presented.

  7. CHOOSING THE POWER OF TRACTION ELECTRIC MOTORS FOR ELECTRIC VEHICLES

    Directory of Open Access Journals (Sweden)

    O. Smirnov

    2017-06-01

    Full Text Available Recommendations on choosing the power of the electric motor, depending on the weight of the vehicle, its speed and the run distance in the «only electricity» mode are developed. Based on mathematical modeling and a number of field tests of electric vehicles, a three-dimensional dependance of the power on the weight and the speed set is built and conclusions are presented.

  8. WHY CHINESE TOURISTS CHOOSE FINLAND AS TRAVEL DESTINATION

    OpenAIRE

    Zheng, Qiaoyin

    2016-01-01

    The purpose of this thesis is to find out the reasons why Chinese tourists choose Finland as travel destination. In this study, the author gives general view of Chinese outbound tourism and comes up with some reasonable recommendations for attracting more Chinese tourists to travel to Finland. Also the aim is to help readers to make improvements for increasing the competitiveness of Finland in the Chinese tourism market. The theoretical framework consist of the theory based on consumer b...

  9. CHOOSING THE RIGHT CLOUD COMPUTING SOLUTION FOR YOU

    OpenAIRE

    Dan Smedescu

    2013-01-01

    This article provides an introduction to cloud computing and choosing a vendor. The first part includes definitions and service models while the body of the article lists pros and cons for specific service models and discusses the cost efficiency of implementing a cloud computing solution. In the last part, a general overview of cloud computing advantages and disadvantages further helps to inform the reader of opportunities and pitfalls.

  10. ALGORITHM TO CHOOSE ENERGY GENERATION MULTIPLE ROLE STATION

    Directory of Open Access Journals (Sweden)

    Alexandru STĂNESCU

    2014-05-01

    Full Text Available This paper proposes an algorithm that is based on a complex analysis method that is used for choosing the configuration of a power station. The station generates electric energy and hydrogen, and serves a "green" highway. The elements that need to be considered are: energy efficiency, location, availability of primary energy sources in the area, investment cost, workforce, environmental impact, compatibility with existing systems, meantime between failure.

  11. Motor heuristics and embodied choices: how to choose and act

    OpenAIRE

    Raab, M

    2017-01-01

    © 2017 Elsevier LtdHuman performance requires choosing what to do and how to do it. The goal of this theoretical contribution is to advance understanding of how the motor and cognitive components of choices are intertwined. From a holistic perspective I extend simple heuristics that have been tested in cognitive tasks to motor tasks, coining the term motor heuristics. Similarly I extend the concept of embodied cognition, that has been tested in simple sensorimotor processes changing decisions...

  12. CHOOSING THE RIGHT FORM OF LICENSING A BUSINESS IN ROMANIA

    Directory of Open Access Journals (Sweden)

    ROIBAN Roxana Nadina

    2012-12-01

    Full Text Available Choosing the most appropriate form of licensing a business is an important decision not easy to be made by an entrepreneur and it should be taken only after he has the required skills and abilities to do so. The business idea should harmonize with the business environment and its future trends, with the existing opportunities and the future products or services that the company will provide and not least the entrepreneur has to make sure that he has sufficient resources to get started. We consider that every business has a number of features that make certain forms of licensing to be more suitable than others. This paper aims to present a multitude of items to be reviewed by an entrepreneur at the start-up in order to choose the most appropriate licensing type for his business. Given that our country's law allows entrepreneurs to license their businesses in several forms, the decision to choose between many existing possibilities is a very important one for the future good of the business. Currently in our country there are two major laws governing the licensing of a business. The first one is the republished and subsequently amended Company Law number 31/1990 and the second, the Government Emergency Ordinance number 44/2008 regarding the economic activities of the Sole traders, Individual enterprises and Family enterprises. The Company Law number 31/1990 allows companies to choose between one of the five types of business entities that can operate in Romania: General partnership (in Romanian SNC, Limited partnership (in Romanian SCS, Limited partnerships by shares (in Romanian SCA, Joint stock company (in Romanian S.A. and Limited liability company (in Romanian S.R.L.. GEO number 44/2008 on economic activities of the Sole traders, Individual enterprises and Family enterprises regulates the licensing and the activity of a Sole traders, Individual enterprises and Family enterprises.

  13. I choose health (Elijo Salud: impacting youth through parish nursing.

    Science.gov (United States)

    Oakley, Janet; Hoebeke, Roberta

    2014-01-01

    The 2009-2010 National Health and Nutritional Examination Survey (NHANES) found that 34% of adolescents are overweight and 18% obese. The chance of an overweight/obese adolescent becoming an overweight/obese adult by age 35 is 60%. Hispanic youth are at risk for becoming obese related to eating habits. This paper describes an intervention, I Choose Health (Elijo Salud), with Hispanic church youth.

  14. 14 CFR 151.47 - Performance of construction work: Letting of contracts.

    Science.gov (United States)

    2010-01-01

    ... Development Projects § 151.47 Performance of construction work: Letting of contracts. (a) Advertising required... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Performance of construction work: Letting... project, each contract for construction work on a project in the amount of more than $2,000 must be...

  15. Let7a involves in neural stem cell differentiation relating with TLX level

    Energy Technology Data Exchange (ETDEWEB)

    Song, Juhyun [Department of Anatomy, Yonsei University College of Medicine, Seoul (Korea, Republic of); Cho, Kyoung Joo; Oh, Yumi [Department of Anatomy, Yonsei University College of Medicine, Seoul (Korea, Republic of); BK21 Plus Project for Medical Sciences, and Brain Research Institute, Yonsei University College of Medicine, Seoul (Korea, Republic of); Lee, Jong Eun, E-mail: jelee@yuhs.ac [Department of Anatomy, Yonsei University College of Medicine, Seoul (Korea, Republic of); BK21 Plus Project for Medical Sciences, and Brain Research Institute, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2015-07-10

    Neural stem cells (NSCs) have the potential for differentiation into neurons known as a groundbreaking therapeutic solution for central nervous system (CNS) diseases. To resolve the therapeutic efficiency of NSCs, recent researchers have focused on the study on microRNA's role in CNS. Some micro RNAs have been reported significant functions in NSC self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. MicroRNA-Let7a (Let7a) has known as the regulator of diverse cellular mechanisms including cell differentiation and proliferation. In present study, we investigated whether Let7a regulates NSC differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal, proliferation and differentiation. We performed the following experiments: western blot analysis, TaqMan assay, RT-PCR, and immunocytochemistry to confirm the alteration of NSCs. Our data showed that let7a play important roles in controlling NSC fate determination. Thus, manipulating Let-7A and TLX could be a novel strategy to enhance the efficiency of NSC's neuronal differentiation for CNS disorders. - Highlights: • Let7a influences on NSC differentiation and proliferation. • Let7a involves in mainly NSC differentiation rather than proliferation. • Let7a positively regulates the TLX expression.

  16. Let7a involves in neural stem cell differentiation relating with TLX level

    International Nuclear Information System (INIS)

    Song, Juhyun; Cho, Kyoung Joo; Oh, Yumi; Lee, Jong Eun

    2015-01-01

    Neural stem cells (NSCs) have the potential for differentiation into neurons known as a groundbreaking therapeutic solution for central nervous system (CNS) diseases. To resolve the therapeutic efficiency of NSCs, recent researchers have focused on the study on microRNA's role in CNS. Some micro RNAs have been reported significant functions in NSC self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. MicroRNA-Let7a (Let7a) has known as the regulator of diverse cellular mechanisms including cell differentiation and proliferation. In present study, we investigated whether Let7a regulates NSC differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal, proliferation and differentiation. We performed the following experiments: western blot analysis, TaqMan assay, RT-PCR, and immunocytochemistry to confirm the alteration of NSCs. Our data showed that let7a play important roles in controlling NSC fate determination. Thus, manipulating Let-7A and TLX could be a novel strategy to enhance the efficiency of NSC's neuronal differentiation for CNS disorders. - Highlights: • Let7a influences on NSC differentiation and proliferation. • Let7a involves in mainly NSC differentiation rather than proliferation. • Let7a positively regulates the TLX expression

  17. Creating effective social marketing: let your customer be your guide.

    Science.gov (United States)

    Brookes, R

    2000-02-01

    Social marketing uses commercial marketing techniques to change behaviors that benefit individuals or society in general. Unlike conventional marketing, which seeks to sell products or services, social marketing aims to promote voluntary behavior change. Some examples of behaviors that have changed due to social marketing are: using seat belts, wearing bike helmets, child immunizations, and smoking cessation. Although good social marketing campaigns use the same techniques as that of commercial marketers, by letting the customer be the guide for all major decisions, it is not primarily advertising and is not about top-down planning and decisions. Instead, it is about having a consumer orientation, which means understanding the target audience very well. An effective social marketer must be committed to ongoing communication with the audience in order to create programs, products, or practice that enable them to make the changes desired.

  18. Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation.

    Science.gov (United States)

    Song, Juhyun; Oh, Yumi; Kim, Jong Youl; Cho, Kyoung Joo; Lee, Jong Eun

    2016-11-01

    Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

  19. Analysis of mutagenic effects induced by carbon beams at different LET in a red yeast strain

    International Nuclear Information System (INIS)

    Sun Haining; Wang Jufang; Ma Shuang; Lu Dong; Wu Xin; Li Wenjian

    2011-01-01

    To evaluate inactive and mutagenic effects of carbon beam at different LET, the inactivation cross section and mutation cross section induced by carbon beams of different LET values were investigated in a red yeast strain Rhodotorula glutinis AY 91015. It was found that the maximum inactivation cross section of 4.37μm 2 , which was very close to the average nucleus cross section, was at LET of 120.0 keV/μm. The maximum mutation cross section was at LET of 96.0 keV/μm. Meanwhile, the highest mutagenicity of carbon ion was found around 58.2 keV/μm. It implied that the most efficient LET to induce mutation in survival yeasts was 58.2 keV/μm, which corresponded to energy of 35 MeV/u carbon beam. The most effective carbon beam to induce inactivation and mutation located at different energy region. (authors)

  20. Potential proteins targeted by let-7f-5p in HeLa cells.

    Science.gov (United States)

    Wang, Yu; Chen, Xiujuan; Zhang, Yi; Song, Jiandong

    2017-07-24

    MicroRNAs are a class of small, endogenous, non-coding RNAs mediating posttranscriptional gene silencing. The current authors hypothesized that let-7f-5p is likely involved in cell invasion and proliferation by regulating the expression of target genes. The current study combined let-7f-5p with iTRAQ to assess its effect on gene expression in HeLa cells. Results indicated that 164 proteins were expressed at different levels in HeLa cells overexpressing let-7f-5p and negative controls and that 172 proteins were expressed at different levels in let-7f-5p-silenced HeLa cells and negative controls. Results indicated that let-7f-5p may suppress insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) in HeLa cells.

  1. CHOOSING TEACHING AS A PROFESSION: INFLUENCE OF BIG FIVE PERSONALITY TRAITS ON FALLBACK CAREER

    Directory of Open Access Journals (Sweden)

    Robert Tomšik

    2018-02-01

    Full Text Available Personality plays a significant role in influencing motivation for choosing a perspective profession. As empirical evidence confirmed, personality traits conscientiousness, openness to experience, extraversion are in positive correlation with intrinsic motives for choosing teaching as a profession (in negative with personality trait neuroticism, and in negative correlation with extrinsic motivation and fallback career (in positive with personality trait neuroticism. The primary aim of research is to point out the importance of personality traits in career choices via detecting which personality traits are predictors of fallback career. In the research first grade university students (teacher trainees; N = 402 completed the Five Factor Inventory and SMVUP-4-S scale. As results show, Big Five personality traits are in correlation with fallback career and are a significant predictor of fallback career. The Big Five model together explained 17.4% of the variance in fallback career, where personality traits agreeableness, conscientiousness, openness to experience and neuroticism has been shown as a statistically significant predictor of fallback career of teacher trainees.

  2. Why do different people choose different university degrees? Motivation and the choice of degree

    Directory of Open Access Journals (Sweden)

    Anya eSkatova

    2014-11-01

    Full Text Available Different people choose which undergraduate degree to study at the university for different reasons. To date, there have been limited attempts to identify individual differences in motivation that drive the undergraduate degree choice. We identified that people choose university degrees for four reasons: career concerns (Career, intrinsic interest (Interest in the subject, an opportunity to help others (Helping and because they are looking for an easy option into higher education (Loafing. We investigated whether these motivation apply to the choice of undergraduate degree in two samples: (1 undergraduate (N = 989 and (2 prospective (N = 896 students. We developed the Motivations Influencing Course Choice (MICC questionnaire to measure these motivations. Scales of Helping, Career, Loafing and Interest showed good psychometric properties, showed validity with respect to general life goals and personality traits, and predicted actual and prospective degree choices. We demonstrated that medical degrees were chosen due to a mixture of Helping and Career, while engineering degrees were associated with Career and low interest in the degree. The choice of art and humanities degrees was driven by Interest and low concern about future career, accompanied with high Loafing. We also demonstrated gender differences: females were high in Helping (both samples and Interest (only in undergraduate sample motivation, while males scored higher in Career (only in undergraduate sample and Loafing (both samples. The findings can feed into both theoretical accounts of proximal motivation as well as help to improve degree programmes at universities and provide better career advice.

  3. Why do different people choose different university degrees? Motivation and the choice of degree.

    Science.gov (United States)

    Skatova, Anya; Ferguson, Eamonn

    2014-01-01

    Different people choose undergraduate degrees to study at university for different reasons. To date, there have been limited attempts to identify individual differences in motivation that drive undergraduate degree choice. We identified that people choose university degrees for four reasons: career concerns (Career), intrinsic interest in the subject (Interest), an opportunity to help others (Helping) and because they are looking for an easy option to get into higher education (Loafing). We investigated whether these motivations apply to the choice of undergraduate degree in two samples: (1) undergraduate (N = 989) and (2) prospective (N = 896) students. We developed the Motivations Influencing Course Choice (MICC) questionnaire to measure these motivations. Scales of Helping, Career, Loafing, and Interest showed good psychometric properties, showed validity with respect to general life goals and personality traits, and predicted actual and prospective degree choices. We demonstrated that medical degrees were chosen due to a mixture of Helping and Career, while engineering degrees were associated with Career and low Interest in the degree. The choice of arts and humanities degrees was driven by Interest and low concern about future career, accompanied with high Loafing. We also demonstrated gender differences: females were high in Helping (both samples) and Interest (only in the undergraduate sample) motivation, while males scored higher in Career (only in the undergraduate sample) and Loafing (both samples). The findings can feed into both theoretical accounts of proximal motivation as well as provide help to improve degree programmes at universities and support better career advice.

  4. Pri-let-7a-1 rs10739971 polymorphism is associated with gastric cancer prognosis and might affect mature let-7a expression

    Directory of Open Access Journals (Sweden)

    Li Y

    2016-07-01

    Full Text Available Ying Li, Qian Xu, Jingwei Liu, Caiyun He, Quan Yuan, Chengzhong Xing, Yuan Yuan Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University, Liaoning Provincial Education Department, Shenyang, People’s Republic of China Abstract: The relationship between the pri-let-7a-1 rs10739971 polymorphism and gastric cancer (GC risk has been reported. However, the role of this polymorphism in the prognosis of GC remains largely elusive. Sequenom MassARRAY platform method and the polymerase chain reaction (PCR-restriction fragment length polymorphism were used to investigate pri-let-7a-1 rs10739971 G→A in 334 GC patients. Real-time PCR detected expression of mature let-7a in serum and tissue. Patients with AA or GA+AA genotypes of the pri-let-7a-1 rs10739971 polymorphism demonstrated significantly longer survival time than those with the wild GG genotype. Stratified analysis indicated that survival time was significantly longer in women with AA or GA+AA genotypes and in Borrmann type I/II patients with GA heterozygote or GA+AA genotypes. AA genotype was more frequent in the lymphatic-metastasis-negative subgroup. Serum mature let-7a expression in healthy people with the GA heterozygote and the GA+AA genotype was higher than in those with the GG genotype, and the difference remained significant in the female healthy subgroup. Pri-let-7a-1 rs10739971 polymorphism might be a biomarker for GC prognosis, especially for female and Borrmann type I/II patients. The pri-let-7a-1 rs10739971 polymorphism might affect serum mature let-7a expression, and partly explain the mechanism of the relationship between the pri-let-7a-1 rs10739971 polymorphism and GC survival. Keywords: miRNA, let-7a, polymorphism, gastric cancer, prognosis, expression

  5. Which IP Strategies Do Young Highly Innovative Firms Choose

    DEFF Research Database (Denmark)

    Veugelers, Reinhilde; Schneider, Cédric

    2018-01-01

    This paper describes and analyzes the strategies of young highly innovative companies to appropriate the returns from their innovations. Upon controlling for other firm and industry characteristics, we show that firms combining a young age and small scale with a high R&D intensive profile are mor...... likely to use intellectual property (IP), specifically combining formal and informal appropriation mechanisms. They are especially more likely to choose secrecy in combination with formal IP. This holds primarily when they introduce more radical innovations new to the market....

  6. Choosing the Right Journal for a Scientific Paper.

    Science.gov (United States)

    Bavdekar, Sandeep B; Save, Sushma

    2015-06-01

    Authors need to take the crucial decision of choosing the journal for their prospective manuscript before even starting to write it. Although, this choice is influenced by many factors, matching the intended recipients of the main message of the manuscript with a journal's readership should override all other consideration in journal selection. That done, availability of time-bound review process,journal's visibility, indexation in databases, regularity of publication, acceptance rate and expenses involved are some other factors that will help decide the choice.

  7. Motor heuristics and embodied choices: how to choose and act.

    Science.gov (United States)

    Raab, Markus

    2017-08-01

    Human performance requires choosing what to do and how to do it. The goal of this theoretical contribution is to advance understanding of how the motor and cognitive components of choices are intertwined. From a holistic perspective I extend simple heuristics that have been tested in cognitive tasks to motor tasks, coining the term motor heuristics. Similarly I extend the concept of embodied cognition, that has been tested in simple sensorimotor processes changing decisions, to complex sport behavior coining the term embodied choices. Thus both motor heuristics and embodied choices explain complex behavior such as studied in sport and exercise psychology. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Choosing the right M and A deal structure

    International Nuclear Information System (INIS)

    Love, A.G.

    1998-01-01

    The legal aspects of going into a merger and acquisition deal within the petroleum industry were reviewed for the benefit of non-lawyers. The types of acquisitions included are asset purchases and sale, a private share purchase and sale, a takeover bid, an amalgamation or a plan of arrangement. How to make the structure choice that is right in the circumstances was discussed. It was emphasized that choosing the right merger and acquisition deal structure depends on the objectives of the parties, the volume and quality of the information about the particular transaction, and proper analysis of alternative acquisition structures in the context of the objectives and information

  9. Categorical and nonparametric data analysis choosing the best statistical technique

    CERN Document Server

    Nussbaum, E Michael

    2014-01-01

    Featuring in-depth coverage of categorical and nonparametric statistics, this book provides a conceptual framework for choosing the most appropriate type of test in various research scenarios. Class tested at the University of Nevada, the book's clear explanations of the underlying assumptions, computer simulations, and Exploring the Concept boxes help reduce reader anxiety. Problems inspired by actual studies provide meaningful illustrations of the techniques. The underlying assumptions of each test and the factors that impact validity and statistical power are reviewed so readers can explain

  10. Marketing and Distribution: Fast Food Placements--Let's Move Slowly

    Science.gov (United States)

    Reece, Barry L.; Stone, James, III

    1978-01-01

    The author presents arguments for and against placing distributive education cooperative students in fast-food outlets, criteria for selecting training stations and students, and a model training plan outline for job and class instruction. (MF)

  11. FORECASTING CAREER PLANNING OF STUDENT OF UNIVERSITY

    Directory of Open Access Journals (Sweden)

    Aleksandra Danilenko

    2012-01-01

    Full Text Available In this article the forecasting model of career planning of student of University. This model has an empirical nature and lets to control the process and the content of student learning taking into account of his individual characteristics and the predictions of his potential careers.

  12. Opting in and Creating Demand: Why Young People Choose to Teach Mathematics to Each Other

    Science.gov (United States)

    Tucker-Raymond, Eli; Lewis, Naama; Moses, Maisha; Milner, Chad

    2016-12-01

    Access to science, technology, engineering, and mathematics fields serves as a key entry point to economic mobility and civic enfranchisement. Such access must take seriously the intellectual power of the knowledge and practices of non-dominant youth. In our case, this has meant to shift epistemic authority in mathematics from academic institutions to young people themselves. This article is about why high school-aged students, from underrepresented groups, choose to participate in an out-of-school time program in which they teach younger children in the domains of mathematics and computer science. It argues for programmatic principles based on access, identity engagement, relationship building, and connections to community to support underrepresented youth as learners, teachers, leaders, and organizers in mathematics-related activities using game design as the focus of activity.

  13. Combined chemo/radiotherapy of cancer: present state and prospects for use with high-LET radiotherapy

    International Nuclear Information System (INIS)

    Phillips, T.L.

    1979-01-01

    Cytotoxic chemotherapy added to low-LET radiotherapy has improved survival and in some cases local control. In some instances the combination has yielded increased normal tissue damage. Similar results can be expected, as confirmed by intestinal crypt cell experiments, with high-LET. Less interaction than with low-LET appears to occur with agents blocking sublethal damage repair or causing synchronization. (author)

  14. In vitro cellular transformation induced by charged particles of defined LET

    International Nuclear Information System (INIS)

    Hei, T.K.; Hall, E.J.; Komatsu, K.; Goldhagen, P.

    1985-01-01

    Cytotoxicity and neoplastic transformation were scored in the C/sub 3/H 10T1/2 cell system following irradiation with protons, deuterons and helium-3 ions of defined LET in the track segment mode. The charged particles were accelerated at the Radiological Research Accelerator Facility at the Nevis Laboratories of Columbia University and provided a range of LET values from 10 to 175 keV/μm. Exponential phase cultures of C3H 10T1/2 cells, growing on a thin mylar surface were irradiated with charged particles of various LET values and subsequently replated onto commercial plastic petri dishes. The cultures were incubated for six weeks at which time they were fixed, stained and type II and III scored as transformants. Over the range of LET values studied thus far, it was found that as the LET of the charged particles increased, the shoulder of the survival curves decreased and approached an exponential function of dose at LET values of 100 keV/μm and above. The transformation incidence, likewise, showed a direct correlation with LET over the dose ranges examined

  15. High-LET dose-response characteristics by track structure theory of heavy charged particles

    International Nuclear Information System (INIS)

    Hansen, J.W.; Olsen, K.J.

    1981-09-01

    The track structure theory developed by Katz and co-workers ascribes the effect of high-LET radiation to the highly inhomogeneous dose distribution due to low energy Δ-rays ejected from the particle track. The theory predicts the effectiveness of high-LET radiation by using the ion parameters zsub(eff') effective charge of the ion, and β = v/c, the relative ion velocity, together with the characteristic dose D 37 derived from low-LET dose-response characteristic of the detector and the approximate size asub(0) of the sensitive element of the detector. 60 Co gamma-irradiation is used as a reference low-LET radiation, while high-LET radiation ranging from 16 MeV protons to 4 MeV/amu 16 0-ions covering an initial LET range of 30-5500 MeVcm 2 /g is obtained from a tandem Van de Graaff accelerator. A thin film (5mg/cm 2 ) radiochromic dye cyanide plastic dosemeter was used as detector with the characteristic dose of 16.8 Mrad and a sensitive element size of 10 -7 cm. Theoretical and experimental effectiveness, RBE, agreed within 10 to 25% depending on LET. (author)

  16. The best motivator priorities parents choose via analytical hierarchy process

    Science.gov (United States)

    Farah, R. N.; Latha, P.

    2015-05-01

    Motivation is probably the most important factor that educators can target in order to improve learning. Numerous cross-disciplinary theories have been postulated to explain motivation. While each of these theories has some truth, no single theory seems to adequately explain all human motivation. The fact is that human beings in general and pupils in particular are complex creatures with complex needs and desires. In this paper, Analytic Hierarchy Process (AHP) has been proposed as an emerging solution to move towards too large, dynamic and complex real world multi-criteria decision making problems in selecting the most suitable motivator when choosing school for their children. Data were analyzed using SPSS 17.0 ("Statistical Package for Social Science") software. Statistic testing used are descriptive and inferential statistic. Descriptive statistic used to identify respondent pupils and parents demographic factors. The statistical testing used to determine the pupils and parents highest motivator priorities and parents' best priorities using AHP to determine the criteria chosen by parents such as school principals, teachers, pupils and parents. The moderating factors are selected schools based on "Standard Kualiti Pendidikan Malaysia" (SKPM) in Ampang. Inferential statistics such as One-way ANOVA used to get the significant and data used to calculate the weightage of AHP. School principals is found to be the best motivator for parents in choosing school for their pupils followed by teachers, parents and pupils.

  17. Applying multicriteria analysis for choosing the best marination for pork

    Directory of Open Access Journals (Sweden)

    Nieto VMOS

    2015-01-01

    Full Text Available Objective. This research aimed to choose a best marination solution using the Analytic Hierarchy Process (AHP. Materials and methods. Pork meat samples were collected in a commercial slaughterhouse, and they were randomly distributed in four treatments with three different salt contents blend. Color, pH, retention of the solution, exudate and cooking loss, shear force and sensory attributes were assessed and evaluated. Multicriteria analysis using AHP was applied to the results in order to choose the best overall marination solution. Criteria used for selection were the physical and sensory characteristics of meat, and based on these criteria were classified solutions marination. Results. Results showed that the combination of the salts was the best alternative (Na2CO3+NaCl+Na5P3O10, followed by the solutions of (Na2CO3 + NaCl, and (Na5P3O10 + NaCl. Conclusions. All tested solutions with the salts used alone or in combination led to better physical and sensory attributes than the meat not marinated.

  18. Hvad er spørgsmålet?

    DEFF Research Database (Denmark)

    Quistgaard, Nana

    2010-01-01

    Data presented in this paper involves asking questions to 15-16 years old students during a science centre visit. The hypothesis was that it is possible to create curiosity and reflection at a science centre by stimulating and facilitating a dialogue. The background was the vast amount of studies...... showing that free-choice, unstructured school trips result in little (if any) student reflection. We have used a dialogic approach to prompt the student's curiosity and reflection. Four students from were chosen to participate in the study. One of the authors took the role as facilitator and joined each...... conducted a brief interview by each exhibit to allow students to reflect upon their experiences. Further, we interviewed the four students one year later in order to find out how the dialogic approach had impacted the students in a longer term.We found that the approach facilitates curiosity and reflection...

  19. PARP-1 is a key player in controlling apoptosis induced by high LET carbon ion beam and low LET gamma radiation in HeLa cells

    International Nuclear Information System (INIS)

    Ghorai, Atanu; Ghosh, Utpal; Bhattacharyya, Nitai P.; Sarma, Asitikantha

    2014-01-01

    PARP-1 inhibitors have long been used as chemo-sensitizer or radio-sensitizer and specific PARP-1 inhibitors are also in clinical trial for the treatment of various cancers. PARP-1 is not only involved in DNA repair but also plays very complex role in induction of apoptosis in postirradiation condition. Our objective is to investigate role of PARP-1 in apoptosis triggered by high LET carbon ion beam (CIB) and low LET gamma. We have treated HeLa and PARP-1 knock down HeLa (Hsil) cells with various doses of CIB and gamma. We measured DNA damage by comet assay and various apoptotic parameters such as nuclear fragmentation, activation of caspase-3,8,9, AIF translocation etc. We observed higher DNA breaks and also higher apoptosis in HsiI cells compared with HeLa cells. Both CIB and gamma treatment results G2/M arrest but unlike gamma CIB makes S-phase delay, implicating that gamma and CIB triggers different pathway after DNA damage. Cell death by CIB or by gamma increased up on knocking down of PARP-1 but increase is higher for high LET CIB compared with low LET gamma. Furthermore, expression level of PARP-1 controls the intensity of overall apoptosis in cells in post-irradiation condition. So, combination of PARP-1 inhibition with high LET CIB could be a promising tool to combat cancer. (author)

  20. Consumer Products Advertised to Save Energy--Let the Buyer Beware.

    Science.gov (United States)

    1981-07-24

    AD-AL06 653 GENERAL ACCOUNTING OFFICE WASHINGTON DC HUMAN RESOUR--ETC F/G 5/3 CONSUMER PRODUCTS ADVERTISED TO SAVE ENERGY--LET THE BUYER BEWA-ETC...COMPTROLLER GENERAL’S CONSUMER PRODUCTS ADVERTISED REPORT TO THE CONGRESS TO SAVE ENERGY- - LET THE BUYER BEWARE D IG E ST In efforts to reduce energy costs...and comparable, GAO believes that the best ad- vice for consumers is "let the buyer beware." (See p. 42.) F’TC ’S COMMENTS FTC said that GAO

  1. Mutagenic action of radiation with different LET on Bacillus subtilis cells

    International Nuclear Information System (INIS)

    Borejko, A.V.; Krasavin, E.A.

    1996-01-01

    The induction of the his - →his + mutants in vegetative and spores of Bacillus subtilis wild type cells irradiated with γ-rays and helium ions (LET=20-80 keV/μm has been investigated. It was shown that the dose dependence of the mutation induction in vegetative cells is described by a linear-quadratic function of dose in case of both γ-rays and helium ions. RBE (LET) dependence on the mutagenic assay is shifted at the low region of LET. (author). 11 refs., 4 figs

  2. Oxygen as a product of water radiolysis in high-LET tracks. II. Radiobiological implications

    International Nuclear Information System (INIS)

    Baverstock, K.F.; Burns, W.G.

    1981-01-01

    Consideration is given to the possibility that molecular oxygen generated in the tracks of energetic heavy ions is responsible for the reduction in oxygen enhancement ratio (OER) with increasing linear energy transfer (LET) observed for the loss of reproductive capacity caused by radiation in many cellular organisms. Yields of oxygen relationship of OER to LET for two organisms, Chlamydomonas reinhardii and Shigella flexneri, using a simple diffusion kinetic model for radiobiological action which takes account of the diffusion of oxygen after its formation. The results of these calculations show that the model accounts well for the shape of the OER vs. LET relationship

  3. Analysis of Mongolian Students' Common Translation Errors and Its Solutions

    Science.gov (United States)

    Zhao, Changhua

    2013-01-01

    In Inner Mongolia, those Mongolian students face lots of difficulties in learning English. Especially the English translation ability of Mongolian students is a weak point. It is worth to think a problem that how to let our students use the English freely on a certain foundation. This article investigates the problems of Mongolian English learners…

  4. General Chemistry Students' Goals for Chemistry Laboratory Coursework

    Science.gov (United States)

    DeKorver, Brittland K.; Towns, Marcy H.

    2015-01-01

    Little research exists on college students' learning goals in chemistry, let alone specifically pertaining to laboratory coursework. Because students' learning goals are linked to achievement and dependent on context, research on students' goals in the laboratory context may lead to better understanding about the efficacy of lab curricula. This…

  5. Dosimetry and microdosimetry using LET spectrometer based on the track-etch detector: radiotherapy Bremsstrahlung beam, onboard aircraft radiation field

    International Nuclear Information System (INIS)

    Jadrnickova, I.; Spurny, F.

    2006-01-01

    The spectrometer of linear energy transfer (Let) based on the chemically etched poly-allyl-diglycol-carbonate (P.A.D.C.) track-etch detector was developed several years ago in our institute. This Let spectrometer enables determining Let of particles approximately from 10 to 700 keV/μm. From the Let spectra, dose characteristics can be calculated. The contribution presents the Let spectra and other dosimetric characteristics obtained onboard a commercial aircraft during more than 6 months long exposure and in the 18 MV radiotherapy Bremsstrahlung beam. (authors)

  6. [Strategies to choose scaffold materials for tissue engineering].

    Science.gov (United States)

    Gao, Qingdong; Zhu, Xulong; Xiang, Junxi; Lü, Yi; Li, Jianhui

    2016-02-01

    Current therapies of organ failure or a wide range of tissue defect are often not ideal. Transplantation is the only effective way for long time survival. But it is hard to meet huge patients demands because of donor shortage, immune rejection and other problems. Tissue engineering could be a potential option. Choosing a suitable scaffold material is an essential part of it. According to different sources, tissue engineering scaffold materials could be divided into three types which are natural and its modified materials, artificial and composite ones. The purpose of tissue engineering scaffold is to repair the tissues or organs damage, so could reach the ideal recovery in its function and structure aspect. Therefore, tissue engineering scaffold should even be as close as much to the original tissue or organs in function and structure. We call it "organic scaffold" and this strategy might be the drastic perfect substitute for the tissues or organs in concern. Optimized organization with each kind scaffold materials could make up for biomimetic structure and function of the tissue or organs. Scaffold material surface modification, optimized preparation procedure and cytosine sustained-release microsphere addition should be considered together. This strategy is expected to open new perspectives for tissue engineering. Multidisciplinary approach including material science, molecular biology, and engineering might find the most ideal tissue engineering scaffold. Using the strategy of drawing on each other strength and optimized organization with each kind scaffold material to prepare a multifunctional biomimetic tissue engineering scaffold might be a good method for choosing tissue engineering scaffold materials. Our research group had differentiated bone marrow mesenchymal stem cells into bile canaliculi like cells. We prepared poly(L-lactic acid)/poly(ε-caprolactone) biliary stent. The scaffold's internal played a part in the long-term release of cytokines which

  7. Injury to the central nervous system after high LET radiation

    International Nuclear Information System (INIS)

    Laramore, G.E.

    1991-01-01

    To date, clinical experiments with high LET irradiation have used fast neutrons, π-mesons, and heavy ions. The data for all of these modalities will be reviewed here, but by far the greatest body of information is for fast neutrons. Boron neutron capture therapy work for brain tumors, and interesting area in its own right, will not be discussed. In the paper, the author considered separately the brain and the spinal cord in terms of radiation effects. Most of the information on the brain comes from the treatment of high-grade gliomas and so the effects of the tumor and its surrounding edema must be folded in. There is, however, some information relating to the treatment of tumors lying adjacent to the brain. The spinal cord data come primarily from the treatment of head and neck tumors and intrathoracic tumors. Because the majority of these tumors were quite advanced, they often caused the patient's early death, and many patients may not have survived long enough to show the effects of radiation damage even if doses were given that exceeded cord tolerance

  8. A clean environmental week: Let the nature breathe.

    Science.gov (United States)

    Moustafa, Khaled

    2017-11-15

    High levels of CO 2 emissions in the atmosphere and toxic pollutants in air, water and food have serious repercussions on all life's systems, including living beings, environment and economy. Everyone on the Earth is concerned by pollution in some way or another, no matter where and how the pollution is produced as airborne and foodborne pollutants could circulate around the world in different ways, through for example climate components (wind, rain) and/or import and export of foodstuffs. Similarly to living beings that take advantage of day-night circadian rhythms to recover after diurnal hardships, the environment in its entirety could also be seen as a complex living system that needs regular breaks to assimilate or ingest toxic pollutants produced during intensive and continuous industrial processes. If greenhouses gas emissions and pollution rates continue to increase at the same rates as they are nowadays, uncontrollable climate effects might be inevitable and the air quality in some crowded cities in the world might be hardly respirable in the future. A global "Clean Environmental Week" is discussed as an attempt toward reducing air pollution and CO 2 emissions through the interruption or reduction of industrial polluting activities regularly, for a week or so per year, to let the nature 'breathe' and recover from environmentally challenging pollutions. A clean environmental period of 10 days per year could reduce CO 2 emissions by about one billion tons of CO 2 per annum. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. TWENTY-ONE-YEAR EXTENSION PROJECT PERFORMANCE "LET'S BREASTFEEDING, MOMMY?"

    Directory of Open Access Journals (Sweden)

    Marizete Argolo Teixeira

    2017-05-01

    Full Text Available Research aiming to describe the actions that were developed by the Extension Project "Let's breastfeed, Mom?" During the 21 years of its performance in Jequié / Bahia and identify the difficulties, facilities and progress of the project. This is a descriptive, quantitative-qualitative study. The data were collected in the archived project documents, analyzed through descriptive statistics and content analysis. The results showed that 8,923 registered postpartum women with educational activities and 1,313 domiciliary visits were carried out, as the main actions carried out by the project. The difficulties were: lack of consumer / permanent materials and human resources; As facilities: responsibility and commitment of the members of the project, as well as the support of the transportation service of the institution. The advances were the elaboration of the research project, with insertion of research fellows, creation of the webpage and the logo. It is necessary to reflect on the difficulties and propose measures to remedy them and thus continue to contribute to the promotion, protection and support of breastfeeding in the Municipality, contributing to the reduction of infant morbidity and mortality

  10. Autonomy and why you can "Never Let Me Go".

    Science.gov (United States)

    Bowyer, Lynne

    2014-06-01

    Kazuo Ishiguro's book Never Let Me Go is a thoughtful and provocative exploration of what it means to be human. Drawing on insights from the hermeneutic-phenomenology of Martin Heidegger, I argue that the movement of Ishiguro's story can be understood in terms of actualising the human potential for autonomous action. Liberal theories take autonomy to be concerned with analytically and ethically isolatable social units directing their lives in accordance with self-interested preferences, arrived at by means of rational calculation. However, I argue that such theories are simplistic abstractions from our human-life world, distorting the fundamental embodied, embedded, and relational nature of autonomy. When we attend closely to our concrete, lived existence we see instead that autonomy is about responding appropriately to others with whom we share a world. As we follow the path of Ishiguro's central character Kathy H., we are shown how an awareness and acceptance of our existential finitude as precarious and fallible creatures is necessary for guiding such appropriate interactions. As Kathy grows and is affirmed into her life-world, which grounds and supports her Being, she moves from heteronomy to autonomy; from being moved by external laws to embodying those laws, thereby becoming autonomous. This is exemplified by her appropriation of the carer role, through which she responds in a fitting way to those with whom she shares her world, bearing the weight of and dwelling responsibly within our human condition.

  11. MicroRNAs let-7b/i suppress human glioma cell invasion and migration by targeting IKBKE directly

    International Nuclear Information System (INIS)

    Tian, Yuan; Hao, Shaobo; Ye, Minhua; Zhang, Anling; Nan, Yang; Wang, Guangxiu; Jia, Zhifan; Yu, Kai; Guo, Lianmei; Pu, Peiyu; Huang, Qiang; Zhong, Yue

    2015-01-01

    We demonstrated that IKBKE is overexpressed in human gliomas and that the downregulation of IKBKE markedly inhibits the proliferative and invasive abilities of glioma cells, which is consistent with the results reported by several different research groups. Therefore, IKBKE represents a promising therapeutic target for the treatment of glioma. In the present study, we verified that the microRNAs let-7b and let-7i target IKBKE through luciferase assays and found that let-7b/i mimics can knock down IKBKE and upregulate E-cadherin through western blot analysis. Moreover, the expression levels of let-7b/i were significantly lower in glioma cell lines than that in normal brain tissues, as determined by quantitative real-time PCR. Furthermore, let-7b/i inhibit the invasion and migration of glioma cells, as determined through wound healing and Transwell assays. The above-mentioned data suggest that let-7b/i inhibit the invasive ability of glioma cells by directly downregulating IKBKE and indirectly upregulating E-cadherin. - Highlights: • Let-7b and let-7i are downregulated in glioma cell lines. • IKBKE is a target gene of let-7b/i. • Let-7b/i inhibit the invasion and migration of glioma cells. • Let-7b/i upregulate E-cadherin by downregulating IKBKE

  12. MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling.

    Science.gov (United States)

    Zhao, Chunnian; Sun, GuoQiang; Li, Shengxiu; Lang, Ming-Fei; Yang, Su; Li, Wendong; Shi, Yanhong

    2010-02-02

    Neural stem cell self-renewal and differentiation is orchestrated by precise control of gene expression involving nuclear receptor TLX. Let-7b, a member of the let-7 microRNA family, is expressed in mammalian brains and exhibits increased expression during neural differentiation. However, the role of let-7b in neural stem cell proliferation and differentiation remains unknown. Here we show that let-7b regulates neural stem cell proliferation and differentiation by targeting the stem cell regulator TLX and the cell cycle regulator cyclin D1. Overexpression of let-7b led to reduced neural stem cell proliferation and increased neural differentiation, whereas antisense knockdown of let-7b resulted in enhanced proliferation of neural stem cells. Moreover, in utero electroporation of let-7b to embryonic mouse brains led to reduced cell cycle progression in neural stem cells. Introducing an expression vector of Tlx or cyclin D1 that lacks the let-7b recognition site rescued let-7b-induced proliferation deficiency, suggesting that both TLX and cyclin D1 are important targets for let-7b-mediated regulation of neural stem cell proliferation. Let-7b, by targeting TLX and cyclin D1, establishes an efficient strategy to control neural stem cell proliferation and differentiation.

  13. MicroRNAs let-7b/i suppress human glioma cell invasion and migration by targeting IKBKE directly

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Yuan; Hao, Shaobo [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China); Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052 (China); Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government (China); Ye, Minhua [Department of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006 (China); Zhang, Anling [Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052 (China); Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government (China); Nan, Yang [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China); Wang, Guangxiu; Jia, Zhifan [Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052 (China); Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government (China); Yu, Kai; Guo, Lianmei [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China); Pu, Peiyu [Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052 (China); Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government (China); Huang, Qiang, E-mail: huangqiang209@163.com [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China); Zhong, Yue, E-mail: zhongyue2457@sina.com [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China)

    2015-03-06

    We demonstrated that IKBKE is overexpressed in human gliomas and that the downregulation of IKBKE markedly inhibits the proliferative and invasive abilities of glioma cells, which is consistent with the results reported by several different research groups. Therefore, IKBKE represents a promising therapeutic target for the treatment of glioma. In the present study, we verified that the microRNAs let-7b and let-7i target IKBKE through luciferase assays and found that let-7b/i mimics can knock down IKBKE and upregulate E-cadherin through western blot analysis. Moreover, the expression levels of let-7b/i were significantly lower in glioma cell lines than that in normal brain tissues, as determined by quantitative real-time PCR. Furthermore, let-7b/i inhibit the invasion and migration of glioma cells, as determined through wound healing and Transwell assays. The above-mentioned data suggest that let-7b/i inhibit the invasive ability of glioma cells by directly downregulating IKBKE and indirectly upregulating E-cadherin. - Highlights: • Let-7b and let-7i are downregulated in glioma cell lines. • IKBKE is a target gene of let-7b/i. • Let-7b/i inhibit the invasion and migration of glioma cells. • Let-7b/i upregulate E-cadherin by downregulating IKBKE.

  14. Somatická analýza posluchačů tělesné výchovy ve čtyřletém sledovaném období Somatic analysis of PE students within a four-year research period

    Directory of Open Access Journals (Sweden)

    Vojtěch Gajda

    2006-02-01

    Full Text Available Moderní pojetí interpretuje sportovní výkon jako vymezený systém prvků, které jsou označovány jako komponenty, determinanty, faktory apod. Velmi důležitou skupinou faktorů jsou faktory somatické, které se týkají podpůrného systému. Za somatické faktory považujeme tělesnou výšku, hmotnost, délkové, šířkové a obvodové rozměry a z nich tedy plynoucí tělesnou stavbu (velmi často vyjádřenou somatotypem. Příspěvek se zabývá tělesnou stavbou studentů oboru TV 1. ročníku, které můžeme považovat za selektovanou skupinu populace s poměrně velkým objemem pohybové aktivity. Šetření bylo prováděno v letech 2001–2004 a bylo do něj zařazeno 265 studentů (166 mužů a 99 žen. Pro zjištění tělesné stavby byl určován somatotyp podle metodiky Heath-Certer (Riegerová & Ulbrichová, 1993. Při srovnání průměrných somatotypů studentů tělesné výchovy v jednotlivých letech jsme nezaznamenali významné rozdíly. Za výjimku můžeme považovat snad jen endomorfní komponentu u mužů, která měla výrazně klesající trend (hodnota se blížila k hranici statistické významnosti α = 0,05. Vzhledem k tomu, že považujeme studenty tělesné výchovy za selektovanou populaci s velkým objemem pohybové aktivity, předpokládali jsme u nich výrazný rozvoj habitu a typ somatotypu, kterým se většina přiblíží optimálnímu somatotypu pro studenty TV (Riegerová & Ulbrichová, 1993. Měření však ukázala, že studenti výrazně zaostávají především v oblasti mezomorfie, což ukazuje také srovnání s populačním normativem. Domníváme se, že zjištěné hodnoty mohou vypovídat o klesající úrovni fyzického a s tím souvisejícího somatického rozvoje naší populace. Modern theories and studies interpret sport performance as a defined system of elements which are characterized as components, determiners, factors, etc. Somatic factors concerning the support system

  15. Issues related to choosing a guard force structure

    International Nuclear Information System (INIS)

    Averbach, C.; Cusack, J.; Green, L.; Higinbotham, W.; Indusi, J.; Marcuse, W.; Weinstock, E.

    1975-01-01

    The establishment of a federal security force has been suggested as an additional step to protect nuclear material. The force would be given the responsibility for guarding nuclear facilities and shipments of nuclear materials. A study to identify the issues that are relevant to choosing between the private guard forces that are presently employed by industry or a guard force under federal authority is summarized. To examine the issues which would be relevant, three possible types of security force structures were selected for comparison: a federal force under central authority, a private guard force employed by or under contract to a facility, and a private arrangement to employ local police officers similar to the arrangement for armed guards at airports. The issues were divided into seven categories: (1) legal considerations, (2) liability, (3) staffing and operations, (4) costs, (5) relationship to off-site forces, (6) management and control, and (7) transportation. (U.S.)

  16. Choosing the right system to manage electricity derivatives

    International Nuclear Information System (INIS)

    Vasey, G.

    1998-01-01

    The alternatives available and the considerations entering into the choice of the right system to manage electricity derivatives are reviewed. The choice of system will be influenced by a variety of factors, among them : (1) business issues, (2) business processes, (3) functionality, (4) technology, (5) integration into the enterprise, and (6) internal and external competition. The system chosen will need to be integrated into the enterprise. Beyond that,it will need executive commitment, dedicated internal resources, qualified assistance from the vendor, willingness to revisit the business processes and make changes when needed, and training and more training. Some factors to take into account when choosing a system vendor are also discussed. Among these good fit to business, system performance, flexibility, reliability, and customization capacity are the most important

  17. Issues related to choosing a guard force structure

    International Nuclear Information System (INIS)

    Auerback, C.; Cusack, J.; Green, L.; Higinbotham, W.; Indusi, J.; Marcuse, W.; Weinstock, E.

    1975-01-01

    The establishment of a federal security force has been suggested as an additional step to protect nuclear material. The force would be given the responsibility for guarding nuclear facilities and shipments of nuclear materials. This paper summarizes a study to identify the issues that are relevant to choosing between the private guard forces that are presently employed by industry or a guard force under federal authority. To examine the issues which would be relevant, three possible types of security force structures were selected for comparison: a federal force under central authority, a private guard force employed by or under contract to a facility, and a private arrangement to employ local police officers similar to the arrangement for armed guards at airports. The issues were divided into seven categories: (1) Legal Considerations, (2) Liability, (3) Staffing and Operations, (4) Costs, (5) Relationship to Off-site Forces, (6) Management and Control, (7) Transportation

  18. Conscience and responsability in choosing the teaching profession

    Directory of Open Access Journals (Sweden)

    Daniela Căprioară

    2017-05-01

    Full Text Available Given the conditions of a society oriented towards material satisfaction, where the didactic profession is sometimes pushed to the limit of social respect, where the lack of motivation and interest for school and learning, in general, is increasingly invoked, there are young people who choose to dedicate their whole energy for training and educating the new generations. The basis of this choice is the consciousness of the role of the teacher in the life of a child and, at the same time, the responsability for the assumed mission: opening the way to knowledge. Vocation and talent are necessary conditions of a successful pedagogical model, but only complemented by the love for children, the desire to contribute to the formation of people, the joy of giving knowledge and love.

  19. On Choosing a Rational Flight Trajectory to the Moon

    Science.gov (United States)

    Gordienko, E. S.; Khudorozhkov, P. A.

    2017-12-01

    The algorithm for choosing a trajectory of spacecraft flight to the Moon is discussed. The characteristic velocity values needed for correcting the flight trajectory and a braking maneuver are estimated using the Monte Carlo method. The profile of insertion and flight to a near-circular polar orbit with an altitude of 100 km of an artificial lunar satellite (ALS) is given. The case of two corrections applied during the flight and braking phases is considered. The flight to an ALS orbit is modeled in the geocentric geoequatorial nonrotating coordinate system with the influence of perturbations from the Earth, the Sun, and the Moon factored in. The characteristic correction costs corresponding to corrections performed at different time points are examined. Insertion phase errors, the errors of performing the needed corrections, and the errors of determining the flight trajectory parameters are taken into account.

  20. Choosing a suitable sample size in descriptive sampling

    International Nuclear Information System (INIS)

    Lee, Yong Kyun; Choi, Dong Hoon; Cha, Kyung Joon

    2010-01-01

    Descriptive sampling (DS) is an alternative to crude Monte Carlo sampling (CMCS) in finding solutions to structural reliability problems. It is known to be an effective sampling method in approximating the distribution of a random variable because it uses the deterministic selection of sample values and their random permutation,. However, because this method is difficult to apply to complex simulations, the sample size is occasionally determined without thorough consideration. Input sample variability may cause the sample size to change between runs, leading to poor simulation results. This paper proposes a numerical method for choosing a suitable sample size for use in DS. Using this method, one can estimate a more accurate probability of failure in a reliability problem while running a minimal number of simulations. The method is then applied to several examples and compared with CMCS and conventional DS to validate its usefulness and efficiency

  1. Choosing to coose: reasons and expectations regarding marriage

    Directory of Open Access Journals (Sweden)

    Alessandra Alves Macedo

    2017-11-01

    Full Text Available The choice of the partner in adult life is considered one of the only choices that is made with freedom, however, loaded with social, personal, family expectations and also motivated by subjective aspects (ANTON, 2002. This paper seeks to describe how in the process of choosing the spouse, family aspects are directly or indirectly involved. A semi-structured interview was conducted to seven women in their first year of marriage. Data were analyzed according to Content Analysis. Three categories were chosen: Family of Origin; Marriage; and Religion. The participants have a vision of how their choice was made, with free choice, yet they were influenced by the beliefs and values of the families of origin. In their first year of marriage, they demonstrate good experience in marriage, and have built a relationship based on dialogues, despite the "sayings and no sayings" of the family of origin and society.

  2. Choosing Values: Public-Private Relationships in a Global Economy

    Science.gov (United States)

    DiMatteo, Larry A.; Maurer, Virginia G.

    2015-01-01

    This article presents a case study that engages students on the legal and ethical issues of doing business abroad. It explores the scenario of direct foreign investment by an American company in a less developed country. This development imbalance necessarily implicates issues of ethical relativism and home-host country standards. Students are…

  3. Motivations for choosing various food groups based on individual foods.

    Science.gov (United States)

    Phan, Uyen T X; Chambers, Edgar

    2016-10-01

    Understanding "why people eat what they eat" is important for improving the lives of people around the world by helping provide industrial and social solutions for people to have greater pleasure and health from the foods they choose. The objective of this study was to investigate the motivations behind everyday choices of different food groups using a bottom-up approach that targeted the specific choices of foods and beverages people consumed at various times of a day. This study was conducted using an online survey included questions related to demographics, the most recent meal including specific food choices, and a slightly modified Eating Motivation Surveys (2 motivations were added, and Check-All-That-Apply procedure was used), which contained 50 sub-scales to measure 17 motivations including such topics as Liking, Pleasure, Convenience, Health, Price, Variety Seeking etc. A total of 198 participants have completed the surveys. Data were analyzed by Correspondence Analysis. Liking was found to be the strongest motivation that drove people to select all sorts of foods. Need and Hunger and Convenience were the main motivations for baked products, "fast" foods, sausages and meats, and snack foods while Health and Weight Control were found to be the main driving factors for vegetables, fruits & fruit juices, nuts, seeds, dairy & egg, and poultry products. Sweets were linked to Pleasure. For beverages, people were motivated most by Heath and Weight Control to choose water and tea. Coffee was used due to Habits; soda was because of Pleasure and alcoholic was for socialization purposes. This study provided developers, marketers, health educators, etc. With a new method to understand food choice in order to promote better eating. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Direct and indirect pathways for choosing objects and actions.

    Science.gov (United States)

    Hikosaka, Okihide; Kim, Hyoung F; Amita, Hidetoshi; Yasuda, Masaharu; Isoda, Masaki; Tachibana, Yoshihisa; Yoshida, Atsushi

    2018-02-23

    A prominent target of the basal ganglia is the superior colliculus (SC) which controls gaze orientation (saccadic eye movement in primates) to an important object. This 'object choice' is crucial for choosing an action on the object. SC is innervated by the substantia nigra pars reticulata (SNr) which is controlled mainly by the caudate nucleus (CD). This CD-SNr-SC circuit is sensitive to the values of individual objects and facilitates saccades to good objects. The object values are processed differently in two parallel circuits: flexibly by the caudate head (CDh) and stably by the caudate tail (CDt). To choose good objects, we need to reject bad objects. In fact, these contrasting functions are accomplished by the circuit originating from CDt: The direct pathway focuses on good objects and facilitates saccades to them; the indirect pathway focuses on bad objects and suppresses saccades to them. Inactivation of CDt deteriorated the object choice, because saccades to bad objects were no longer suppressed. This suggests that the indirect pathway is important for object choice. However, the direct and indirect pathways for 'object choice', which aim at the same action (i.e., saccade), may not work for 'action choice'. One possibility is that circuits controlling different actions are connected through the indirect pathway. Additional connections of the indirect pathway with brain areas outside the basal ganglia may also provide a wider range of behavioral choice. In conclusion, basal ganglia circuits are composed of the basic direct/indirect pathways and additional connections and thus have acquired multiple functions. © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  5. The dynamic model of choosing an external funding instrument

    Directory of Open Access Journals (Sweden)

    Irena HONKOVA

    2015-06-01

    Full Text Available Making a decision about using a specific funding source is one of the most important tasks of financial management. The utilization of external sources features numerous advantages yet staying aware of diverse funding options is not easy for financial managers. Today it is crucial to quickly identify an optimum possibility and to make sure that all relevant criteria have been considered and no variant has been omitted. Over the long term it is also necessary to consider the category of time as changes made today do not affect only the current variables but they also have a significant impact on the future. This article aims to identify the most suitable model of choosing external funding sources that would describe the dynamics involved. The first part of the paper considers the theoretical background of external funding instrument and of decision criteria. The making of financial decisions is a process consisted of weighing the most suitable variants, selecting the best variant, and controlling the implementation of accepted proposals. The second part analyses results of the research - decisive weights of the criteria. Then it is created the model of the principal criteria Weighted Average Cost of Capital (Dynamic model WACC. Finally it is created the Dynamic Model of Choosing an External Funding Instrument. The created decision-making model facilitates the modeling of changes in time because it is crucial to know what future consequences lies in decisions made the contemporary turbulent world. Each variant features possible negative and positive changes of varying extent. The possibility to simulate these changes can illustrate an optimal variant to a decision-maker.

  6. Factors influencing publication choice: why faculty choose open access.

    Science.gov (United States)

    Warlick, Stefanie E; Vaughan, Ktl

    2007-03-09

    In an attempt to identify motivating factors involved in decisions to publish in open access and open archives (OA) journals, individual interviews with biomedical faculty members at the University of North Carolina at Chapel Hill (UNC-Chapel Hill) and Duke University, two major research universities, were conducted. The interviews focused on faculty identified as early adopters of OA/free full-text publishing. Searches conducted in PubMed and PubMed Central identified faculty from the two institutions who have published works in OA/free full-text journals. The searches targeted authors with multiple OA citations during a specified 18 month period. Semi-structured interviews were conducted with the most prolific OA authors at each university. Individual interviews attempted to determine whether the authors were aware they published in OA journals, why they chose to publish in OA journals, what factors influenced their publishing decisions, and their general attitude towards OA publishing models. Fourteen interviews were granted and completed. Respondents included a fairly even mix of Assistant, Associate and Full professors. Results indicate that when targeting biomedical faculty at UNC-Chapel Hill and Duke, speed of publication and copyright retention are unlikely motivating factors or incentives for the promotion of OA publishing. In addition, author fees required by some open access journals are unlikely barriers or disincentives. It appears that publication quality is of utmost importance when choosing publication venues in general, while free access and visibility are specifically noted incentives for selection of OA journals. Therefore, free public availability and increased exposure may not be strong enough incentives for authors to choose open access over more traditional and respected subscription based publications, unless the quality issue is also addressed.

  7. Choosing phenomenology as a guiding philosophy for nursing research.

    Science.gov (United States)

    Matua, Gerald Amandu

    2015-03-01

    To provide an overview of important methodological considerations that nurse researchers need to adhere to when choosing phenomenology as a guiding philosophy and research method. Phenomenology is a major philosophy and research method in the humanities, human sciences and arts disciplines with a central goal of describing people's experiences. However, many nurse researchers continue to grapple with methodological issues related to their choice of phenomenological method. The author conducted online and manual searches of relevant research books and electronic databases. Using an integrative method, peer-reviewed research and discussion papers published between January 1990 and December 2011 and listed in the CINAHL, Science Direct, PubMed and Google Scholar databases were reviewed. In addition, textbooks that addressed research methodologies such as phenomenology were used. Although phenomenology is widely used today to broaden understanding of human phenomena relevant to nursing practice, nurse researchers often fail to adhere to acceptable scientific and phenomenological standards. Cognisant of these challenges, researchers are expected to indicate in their work the focus of their investigations, designs, and approaches to collecting and analysing data. They are also expected to present their findings in an evocative and expressive manner. Choosing phenomenology requires researchers to understand it as a philosophy, including basic assumptions and tenets of phenomenology as a research method. This awareness enables researchers, especially novices, to make important methodological decisions, particularly those necessary to indicate the study's scientific rigour and phenomenological validity. This paper adds to the discussion of phenomenology as a guiding philosophy for nursing research. It aims to guide new researchers on important methodological decisions they need to make to safeguard their study's scientific rigour and phenomenological validity.

  8. Choosing the right amount of healthcare information technologies investments.

    Science.gov (United States)

    Meyer, Rodolphe; Degoulet, Patrice

    2010-04-01

    Choosing and justifying the right amount of investment in healthcare information technologies (HITECH or HIT) in hospitals is an ever increasing challenge. Our objectives are to assess the financial impact of HIT on hospital outcome, and propose decision-helping tools that could be used to rationalize the distribution of hospital finances. We used a production function and microeconomic tools on data of 21 Paris university hospitals recorded from 1998 to 2006 to compute the elasticity coefficients of HIT versus non-HIT capital and labor as regards to hospital financial outcome and optimize the distribution of investments according to the productivity associated with each input. HIT inputs and non-HIT inputs both have a positive and significant impact on hospital production (elasticity coefficients respectively of 0.106 and 0.893; R(2) of 0.92). We forecast 2006 results from the 1998 to 2005 dataset with an accuracy of +0.61%. With the model used, the best proportion of HIT investments was estimated to be 10.6% of total input and this was predicted to lead to a total saving of 388 million Euros for the 2006 dataset. Considering HIT investment from the point of view of a global portfolio and applying econometric and microeconomic tools allow the required confidence level to be attained for choosing the right amount of HIT investments. It could also allow hospitals using these tools to make substantial savings, and help them forecast their choices for the following year for better HITECH governance in the current stimulation context. (c) 2010 Elsevier Ireland Ltd. All rights reserved.

  9. LET spectrometry with track etch detectors-Use in high-energy radiation fields

    International Nuclear Information System (INIS)

    Jadrnickova, I.; Spurny, F.

    2008-01-01

    For assessing the risk from ionizing radiation it is necessary to know not only the absorbed dose but also the quality of the radiation; radiation quality is connected with the physical quantity linear energy transfer (LET). One of the methods of determination of LET is based on chemically etched track detectors. This contribution concerns with a spectrometer of LET based on the track detectors and discusses some results obtained at: ·high-energy radiation reference field created at the SPS accelerator at CERN; and ·onboard of International Space Station where track-etch based LET spectrometer has been exposed 273 days during 'Matrjoshka - R' experiment. Results obtained are compared with the results of studies at some lower-energy neutron sources; some conclusions on the registrability of neutrons and the ability of this spectrometer to determine dose equivalent in high-energy radiation fields are formulated

  10. Mechanism and significance of let-7 in diagnosis and treatment of hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    HUO Tingting

    2017-07-01

    Full Text Available Abstract:MicroRNA (miRNA play important roles in post-transcriptional gene regulation. In recent years, miRNA has become a hot topic in the research on the development and progression of tumors, and gene targeting therapy for malignant tumors has achieved preliminary progress. As one of the first discovered miRNA, let-7 can regulate the cell cycle and angiogenesis and is involved in the proliferation, differentiation, and apoptosis of various tumor cells. Most members of the let-7 family can act as tumor suppressor gene and have low expression in various tumor tissues and high expression in the serum of patients with malignant tumors. Let-7 is closely associated with the invasion and drug resistance of hepatocellular carcinoma (HCC. The studies above show that let-7 might become a new marker for the early diagnosis of HCC and provide new targets for the treatment of HCC.

  11. let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis

    Directory of Open Access Journals (Sweden)

    M. Patterson

    2014-11-01

    Full Text Available It is clear that neural differentiation from human pluripotent stem cells generates cells that are developmentally immature. Here, we show that the let-7 plays a functional role in the developmental decision making of human neural progenitors, controlling whether these cells make neurons or glia. Through gain- and loss-of-function studies on both tissue and pluripotent derived cells, our data show that let-7 specifically regulates decision making in this context by regulation of a key chromatin-associated protein, HMGA2. Furthermore, we provide evidence that the let-7/HMGA2 circuit acts on HES5, a NOTCH effector and well-established node that regulates fate decisions in the nervous system. These data link the let-7 circuit to NOTCH signaling and suggest that this interaction serves to regulate human developmental progression.

  12. Eesti ja Soome kooliõpilased toovad lavale muusikali "Let Mamma Mia in!"

    Index Scriptorium Estoniae

    2006-01-01

    21. okt. Kaja keskuses etendavad Tallinna 32. keskkooli ja Meri-Porin Lukio õpilased muusikali "Let Mamma Mia in". Muusikal koosneb muusikalihittidest, mille on looks kokku kirjutanud Sven Kivisildnik

  13. When Your Back Hurts: Don't Let Back Pain Knock You Flat

    Science.gov (United States)

    ... Your Back Hurts Don’t Let Back Pain Knock You Flat En español Send us your comments ... Complementary Health Approaches Halt the Hurt! References The SPORT Value Compass: Do the Extra Costs of Undergoing ...

  14. A method for radiobiological investigations in radiation fields with different LET and high dose rates

    International Nuclear Information System (INIS)

    Grundler, W.

    1976-01-01

    For investigations: 1. Performed in the field of radiobiology with different LET-radiation and a relatively high background dose rate of one component (e.g. investigations with fast and intermediate reactor neutrons) 2. Concerning radiation risk studies within a wide range 3. Of irradiations, covering a long time period (up to 100 days) a test system is necessary which on the one hand makes it possible to analyze the influence of different LET radiation and secondly shows a relative radiation resistant behaviour and allows a simple cell cycle regulation. A survey is given upon the installed device of a simple cell observation method, the biological test system used and the analysis of effects caused by dose, repair and LET. It is possible to analyze the behaviour of the nonsurvival cells and to demonstrate different reactions of the test parameters to the radiation of different LET. (author)

  15. Induction and disappearance of G2 chromatid breaks in lymphocytes after low doses of low LET γ - rays and high LET fast neutrons

    International Nuclear Information System (INIS)

    Vral, Anne; Thierens, Hubert; Baeyens, Ans; De Ridder, Leo

    2001-01-01

    In view of the potential importance of the G2 assay for detecting chromosomal radiosensitivity and possible predisposition to cancer the need to elucidate the mechanism underlying the formation of chromatid breaks, observed with the G2 assay after low dose irradiation, has been recognised. In this study we irradiated blood samples of 4 healthy donors with low LET γ-rays and high LET neutrons, which initially produce the same number of dsb but of a different quality. By means of the G2 assay, we determined the number of chromatid breaks induced by γ-rays and neutrons and compared the kinetics of chromatid break rejoining for radiations of different quality. In a first set of experiments a dose-response curve for the formation of chromatid breaks was carried out for γ-rays and neutrons with doses ranging between 0.1 and 0.5 Gy. In a second set of experiments the kinetics of chromatid break formation and disappearance was investigated after a dose of 0.5 Gy using post-irradiation times ranging between 0.5 h and 3.5 h. For the highest dose of 0.5 Gy the number of isochromatid breaks were also scored. No significant differences in the number of chromatid breaks were observed between low LET γ-rays and high LET neutrons for the 4 donors at any of the doses given. The dose response curves for the formation of chromatid breaks are linear for both radiation qualities and RBE values equal to one were obtained. Scoring of isochromatid breaks at the highest dose of 0.5 Gy revealed that high LET neutrons are however more effective at inducing isochromatid breaks (RBE of 6.2). The rejoining experiments further showed that the kinetics of disappearance of chromatid breaks following irradiation with low LET γ-rays or high-LET neutrons are not significantly different. T 1/2 0.92 h for γ-rays and t 1/2 = 0.84 h for neutrons were obtained. In conclusion, our results show that at low doses of radiation the induction as well as the disappearance of G2 chromatid breaks is LET

  16. Motivation for choosing teaching as a career - the perspective of pre-service teachers, novices and experienced subject teachers

    Directory of Open Access Journals (Sweden)

    Simić Nataša

    2015-01-01

    Full Text Available Since motivation for choosing the teaching profession figures as one of the most important determinants of the successfulness of teachers and even their students, this paper is aimed at investigating the factors of choosing teaching as a career. For that purpose, semi-structured interviews were conducted with the students of “teacher training” faculties, novices and subject teachers with more than five years of work experience (N=76. Thematic analysis was used to identify nine categories of motivational factors: Working with young people (the desire to have a dynamic and creative job in the surroundings of young people, Influence on students (the motivation to exert influence on students’ socio-emotional development, values and education, Dealing with the subject (the motivation for dealing with the science that the person studied, Class teacher/Teacher/Parents as a role model (the motivation stemming from the influence of significant others, Lecturing (the desire to “transfer knowledge”, Lifelong learning (the desire for permanent learning in different fields, Working hours and holidays (the motivation due to working hours and holidays, Fit with the abilities (the desire to realise the “naturally given” abilities and Reputation (the desire to be appreciated in the society. In keeping with the results of other studies, it has been found that altruistic motivation for the choice of teaching as a career is dominant, while extrinsic motivation is least present. The findings are interpreted in the light of the current models of motivation for choosing teaching as a career and the characteristics of teachers’ education and status in Serbia. [Projekat Ministarstva nauke Republike Srbije, br. 179018: Identifikacija, merenje i razvoj kognitivnih i emocionalnih kompetencija važnih društvu orijentisanom na evropske integracije

  17. Why we should let the Lisbon treaty rest in peace

    DEFF Research Database (Denmark)

    Beach, Derek

    2008-01-01

    Should the Irish be forced to vote again on the recently rejected Lisbon Treaty in a second referendum? The diplomatic signals coming from Brussels suggest that the Irish will be asked to solve the problem themselves using the Danish/Irish model of sending the same treaty with some clarifications...... on sensitive issues to a second vote. EU governments must therefore seriously consider in the coming days whether the Lisbon Treaty is really worth the risk of continuing the ratification process and forcing the Irish to vote again.  Given the modest nature of the reforms in the Treaty and evidence showing...... that the EU-27 actually is able to function under the current rules, governments should back away from talk of a serious crisis facing the EU in the event of non-ratification of the Lisbon Treaty. If they choose to press forward ratification and force the Irish to vote again on the more-or-less the same...

  18. Radiography and scanner: let us ask the right questions

    International Nuclear Information System (INIS)

    2012-07-01

    By answering simple questions, this document proposes a brief overview of radiographic and scanner-based examinations. It recalls that these both techniques use X rays, the cumulative dose of which could slightly increase a risk of cancer on a long term. It outlines that the benefits of these examinations are much more important that the related risks. It indicates the received dose (compared to a daily natural irradiation) for different kinds of examination and for different parts of the human body. It outlines the sensitivity of children to X rays, gives some recommendations regarding these examinations (they are not automatic; the doctor must explain why he chooses them, previous examinations and photos must be kept and brought with; the received dose must be specified in the examination report)

  19. Consumer Decision-Making Based on Review Websites: Are There Differences Between Choosing a Hotel and Choosing a Physician?

    Science.gov (United States)

    Germeni, Evi; Schulz, Peter J

    2016-01-01

    Background Web users are increasingly encouraged to rate and review consumer services (eg, hotels, restaurants) and, more recently, this is also the case for physicians and medical services. The resemblance in the setup and design of commercial rating websites (CRWs) and Web-based physician rating websites (PRWs) raises the question of whether choice-making processes based on the two types of websites could also be similar. Objective This qualitative study sought to explore the extent to which consumer decision making based on Web-based reviews is the same for consumer services (ie, choice of a hotel) and health services (ie, choice of a pediatrician), while providing an in-depth understanding of potential differences or similarities. Methods Between June and August 2015, we carried out a total of 22 qualitative interviews with young parents residing in the German-speaking part of Switzerland. Participants were invited to complete 2 choice tasks, which involved (1) choosing a hotel based on the commercial Web-based rating website TripAdvisor and (2) selecting a pediatrician based on the PRW Jameda. To better understand consumers’ thought processes, we instructed participants to “think aloud”, namely to verbalize their thinking while sorting through information and reaching decisions. Using a semistructured interview guide, we subsequently posed open-ended questions to allow them to elaborate more on factors influencing their decision making, level of confidence in their final choice, and perceived differences and similarities in their search for a hotel and a physician. All interviews were recorded, transcribed, and analyzed using an inductive thematic approach. Results Participants spent on average 9:57 minutes (standard deviation=9:22, minimum=3:46, maximum=22:25) searching for a hotel and 6:17 minutes (standard deviation=4:47, minimum=00:38, maximum=19:25) searching for a pediatrician. Although the choice of a pediatrician was perceived as more important

  20. Consumer Decision-Making Based on Review Websites: Are There Differences Between Choosing a Hotel and Choosing a Physician?

    Science.gov (United States)

    Rothenfluh, Fabia; Germeni, Evi; Schulz, Peter J

    2016-06-16

    Web users are increasingly encouraged to rate and review consumer services (eg, hotels, restaurants) and, more recently, this is also the case for physicians and medical services. The resemblance in the setup and design of commercial rating websites (CRWs) and Web-based physician rating websites (PRWs) raises the question of whether choice-making processes based on the two types of websites could also be similar. This qualitative study sought to explore the extent to which consumer decision making based on Web-based reviews is the same for consumer services (ie, choice of a hotel) and health services (ie, choice of a pediatrician), while providing an in-depth understanding of potential differences or similarities. Between June and August 2015, we carried out a total of 22 qualitative interviews with young parents residing in the German-speaking part of Switzerland. Participants were invited to complete 2 choice tasks, which involved (1) choosing a hotel based on the commercial Web-based rating website TripAdvisor and (2) selecting a pediatrician based on the PRW Jameda. To better understand consumers' thought processes, we instructed participants to "think aloud", namely to verbalize their thinking while sorting through information and reaching decisions. Using a semistructured interview guide, we subsequently posed open-ended questions to allow them to elaborate more on factors influencing their decision making, level of confidence in their final choice, and perceived differences and similarities in their search for a hotel and a physician. All interviews were recorded, transcribed, and analyzed using an inductive thematic approach. Participants spent on average 9:57 minutes (standard deviation=9:22, minimum=3:46, maximum=22:25) searching for a hotel and 6:17 minutes (standard deviation=4:47, minimum=00:38, maximum=19:25) searching for a pediatrician. Although the choice of a pediatrician was perceived as more important than the choice of a hotel, participants

  1. A Thematic Unit: Let's Go to School in Japan!

    Science.gov (United States)

    Haxhi, Jessica

    2009-01-01

    During this five-day unit, students will enter the world of a Japanese classroom. They will talk about school uniforms, "fill" their backpacks with school items, and learn how to do a simple self-introduction in front of their peers. Students will participate in the cultural customs of a Japanese classroom and view pictures, videos, and…

  2. Exploring the Solar System? Let the Math Teachers Help!

    Science.gov (United States)

    Charles, Karen; Canales, J. D.; Smith, Angela; Zimmerman, Natalie

    2012-01-01

    Scale measurement and ratio and proportion are topics that fall clearly in the middle-grades mathematics curriculum in Texas. So does the solar system. In their experience, the authors have found that students have trouble manipulating, much less comprehending, very large numbers and very small numbers. These concepts can be brought into students'…

  3. Trends in Defamation Law: Let the Advisor Beware.

    Science.gov (United States)

    King, Robert D.

    1992-01-01

    Although most lawsuits brought by students against a college are grounded on contract and due process theories, courts have been willing to consider students' defamation suits using tort theories. Recent changes in defamation law have engendered increased litigation and risk of liability for faculty and advisors. (Author/MSE)

  4. Let's Get Higher Scores on These New Assessments

    Science.gov (United States)

    Shanahan, Timothy

    2015-01-01

    This column explains three ways that teachers can improve reading test performance. Basically, the idea is that instead of teaching students to respond to particular question types as is typical of test preparation despite the ineffectiveness of this practice, it is better to teach students to read the test passages more effectively. Three…

  5. Let's Repair the Broken Galileo Thermometer

    Science.gov (United States)

    Kireš, Marián

    2018-01-01

    We have developed and verified laboratory work as guided inquiry for upper secondary level students, focusing on conceptual understanding of the physical principle that forms the basis of temperature measurement, and on improvement of selected skills. Conceptual pre-test questions initiate the students' interest and help identify input…

  6. Let's Think about What We're Doing.

    Science.gov (United States)

    Watt, Jan

    2003-01-01

    Describes the author's experience when a student was killed drunk-driving. Outlines six major issues related to youth: alcohol; drugs; risky sexual behavior; music; violence; and values, morals, and ethics. Proposes that these six issues need to be covered more in student newspapers. (PM)

  7. Motivations for and barriers to choosing an interventional cardiology career path: results from the EAPCI Women Committee worldwide survey.

    Science.gov (United States)

    Capranzano, Piera; Kunadian, Vijay; Mauri, Josepa; Petronio, Anna Sonia; Salvatella, Neus; Appelman, Yolande; Gilard, Martine; Mikhail, Ghada W; Schüpke, Stefanie; Radu, Maria D; Vaquerizo, Beatriz; Presbitero, Patrizia; Morice, Marie-Claude; Mehilli, Julinda

    2016-05-17

    Very few women become interventional cardiologists, although a substantial proportion of cardiologists and the majority of medical students are women. In accordance with the EAPCI Women Committee mission of attaining gender equality at the professional level, a worldwide survey was recently conducted aiming to understand better the motivations and the barriers for women in selecting interventional cardiology (IC) as a career path. A total of 1,787 individuals (60.7% women) responded to the survey. Women compared to men were less frequently married (women vs. men, 57.0% vs. 79.8%, pmen replying to why, in their opinion, women do not choose IC, on-calls and long working hours were the most frequent reasons (35.3%). Several barriers preclude women from choosing IC, including lack of opportunity, concerns regarding radiation exposure and the prejudices of their male colleagues. This highlights the need to develop new strategies for future training, education, and support of women in order to choose IC.

  8. Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction.

    Directory of Open Access Journals (Sweden)

    Manoj K Mishra

    Full Text Available Duchenne muscular dystrophy (DMD is a fatal genetic disease caused by an absence of the 427kD muscle-specific dystrophin isoform. Utrophin is the autosomal homolog of dystrophin and when overexpressed, can compensate for the absence of dystrophin and rescue the dystrophic phenotype of the mdx mouse model of DMD. Utrophin is subject to miRNA mediated repression by several miRNAs including let-7c. Inhibition of utrophin: let-7c interaction is predicted to 'repress the repression' and increase utrophin expression. We developed and tested the ability of an oligonucleotide, composed of 2'-O-methyl modified bases on a phosphorothioate backbone, to anneal to the utrophin 3'UTR and prevent let-7c miRNA binding, thereby upregulating utrophin expression and improving the dystrophic phenotype in vivo. Suppression of utrophin: let-7c interaction using bi-weekly intraperitoneal injections of let7 site blocking oligonucleotides (SBOs for 1 month in the mdx mouse model for DMD, led to increased utrophin expression along with improved muscle histology, decreased fibrosis and increased specific force. The functional improvement of dystrophic muscle achieved using let7-SBOs suggests a novel utrophin upregulation-based therapeutic strategy for DMD.

  9. Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma

    Science.gov (United States)

    Powers, John T; Tsanov, Kaloyan M; Pearson, Daniel S; Roels, Frederik; Spina, Catherine S; Ebright, Richard; Seligson, Marc; de Soysa, Yvanka; Cahan, Patrick; Theiβen, Jessica; Tu, Ho-Chou; Han, Areum; Kurek, Kyle C; LaPier, Grace S; Osborne, Jihan K; Ross, Samantha J; Cesana, Marcella; Collins, James J; Berthold, Frank; Daley, George Q

    2016-01-01

    Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumor suppressor family of microRNAs implicated in numerous cancers. LIN28B, an inhibitor of let-7 biogenesis, is overexpressed in neuroblastoma and has been reported to regulate MYCN. However, here we show that LIN28B is dispensable in MYCN-amplified neuroblastoma cell lines, despite de-repression of let-7. We further demonstrate that MYCN mRNA levels in amplified disease are exceptionally high and sufficient to sponge let-7, which reconciles the dispensability of LIN28B. We found that genetic loss of let-7 is common in neuroblastoma, inversely associated with MYCN-amplification, and independently associated with poor outcomes, providing a rationale for chromosomal loss patterns in neuroblastoma. We propose that let-7 disruption by LIN28B, MYCN sponging, or genetic loss is a unifying mechanism of neuroblastoma pathogenesis with broad implications for cancer pathogenesis. PMID:27383785

  10. Improvement of date palm plant lets during rooting stage by silver ion

    International Nuclear Information System (INIS)

    Sharaf, M.M.; Khamis, M.A.; El Bana, A.; Abd El Galeil, L.M.; Zaid, Z.E.

    2012-01-01

    This study aim to promote growth plant lets of date palm cv. Zaghlool by decreasing ethylene production inside the containers during rooting stage. Data obtained declared that three silver thiosulphate (STS) levels added to one half strength MS rooting medium improved significantly three rooting measurements (rooting percentage; number and length of developed root lets). However, the lightest STS level (0.25 ml/L of 4 mM STS solution) was the superior, while highest one (1.0 ml/L) was the inferior from statistical point of view. Data obtained displayed that providing MS rooting medium with silver nitrate improved 3 rooting measurements (rooting %; number of root lets and their length) for Zaghloul date palm shoot lets proliferated from somatic embryos. However, the 0.50 mg/L AgNO 3 provided MS medium was the most preferable in this concern. Plant lets were transferred to capped tubes contained 1/4 liquid MS medium through 3 weeks in the growth chamber (under aseptic condition). Ventilation was allowed gradually by punching holes in aluminum foil caps during first five days of 2 nd week. After then, the plant lets were transplanted in acclimatization green house on mixture from (peat moss + perlite + vermiculite at 1:1:1) and survival percentage was 75% after three months.

  11. Diffusion-kinetic theories for LET effects on the radiolysis of water

    International Nuclear Information System (INIS)

    Pimblott, S.M.; LaVerne, J.A.

    1994-01-01

    Diffusion-kinetic methods are used to investigate the effects of incident particle linear energy transfer (LET) on the radiolysis of water and aqueous solutions. Chemically realistic deterministic diffusion-kinetic calculations examining the scavenging capacity dependences of the scavenged yield of e aq - and of OH demonstrate that the scavenged yields are related to the underlying time-dependent kinetics in the absence of the scavenger by a simple Laplace transform relationship. This relationship is also shown to link the effect of an e eq - scavenger on the formation of H 2 with the time dependence of H 2 production in the absence of the scavenger. The simple Laplace relationship does not work well when applied to H 2 O 2 formation in high-LET particle tracks even though such a relationship is valid with low-LET particles. It is found that while the secondary reaction of H 2 O 2 with e aq - can be neglected in low-LET particle radiolysis, it is of considerable significance in the tracks produced by high-LET particles. The increased importance of this reaction with increasing LET is the major reason for the failure of the Laplace relationship for H 2 O 2 . 55 refs., 9 figs., 2 tabs

  12. African primary care research: Choosing a topic and developing a proposal

    Directory of Open Access Journals (Sweden)

    Bob Mash

    2014-02-01

    Full Text Available This is the first in a series of articles on primary care research in the African context. The aim of the series is to help build capacity for primary care research amongst the emerging departments of family medicine and primary care on the continent. Many of the departments are developing Masters of Medicine programmes in Family Medicine and their students will all be required to complete research studies as part of their degree. This series is being written with this audience in particular in mind – both the students who must conceptualise and implement a research project as well as their supervisors who must assist them.This article gives an overview of the African primary care context, followed by a typology of primary care research. The article then goes on to assist the reader with choosing a topic and defining their research question. Finally the article addresses the structure and contents of a  research proposal and the ethical issues that should be considered.

  13. Personal values Involved in choosing a College: Analysis Using the Means-End Chain Approach

    Directory of Open Access Journals (Sweden)

    Lílian Carolina Viana

    2014-04-01

    Full Text Available The investigation the reasons for choice of products and services by consumers stands out as relevant in the area of ​​market studies, as well as notes management for any organization. Through the Theory of Means-End Chain proposed by Gutman (1982, which relates the “means” (attributes and benefits linked to the consumption of products or services with the “ends” in terms of personal values achieved, it is possible understand of the meanings that consumers attribute the choice of products and services in a more abstract level. Thus, the objective of this study is to understand what aspects, considering attributes, consequences and personal values ​​guide the behavior of students in choosing the nursing course at a private institution of higher education. Based on the theory mentioned it was adopted the technique laddering, in-depth interview and analysis methodology and representation of the hierarchical value map, which was interpreted and analyzed in order to understand the cognitive structure of students’ choice.The analysis of the results indicate that students are guided primarily by hedonistic values of happiness itself the choice of nursing in college studied.

  14. Models for cell survival with low LET radiation

    International Nuclear Information System (INIS)

    Payne, M.G.; Garrett, W.R.

    1975-01-01

    A model for cell survival under low LET irradiation was developed in which the cell is considered to have N 0 -independent sensitive sites, each of which can exist in either an undamaged state (state A) or one of two damaged states. Radiation can change the sensitive sites from the undamaged state to either of two damaged states. The first damaged state (state B) can either be repaired or be promoted on the second damaged state (state C), which is irreparable. The promotion from the first damaged state to the second can occur due to any of the following: (1) further radiation damage, (2) an abortive attempt to repair the site, or (3) the arrival at a part of the cell cycle where the damage is ''fixed.'' Subject to the further assumptions that radiation damage can occur either indirectly (i.e., through radiation products) or due to direct interaction, and that repair of the first damaged state is a one-step process, expressions can be derived for P(N/sub A/, N/sub B/,t) = probability that after time t a cell will have N/sub A/ sites in state A and N/sub B/ in state B. The problem of determining P(N/sub A/, N/sub B/, t) is formulated for arbitrary time dependences of the radiation field and of all rate coefficients. A large family of cell-survival models can be described by interpreting the sensitive sites in different ways and by making different choices of rate coefficients and of the combinations of numbers of sites in different states that will lead to cell death. (U.S.)

  15. Generalized concept of the LET-RBE relationship of radiation-induced chromosome aberration and cell death

    International Nuclear Information System (INIS)

    Takatsuji, Toshihiro; Yoshikawa, Isao; Sasaki, Masao S.

    1999-01-01

    The frequency of chromosome aberrations per traversal of a nucleus by a charged particle at the low dose limit increases proportionally to the square of the linear energy transfer (LET), peaks at about 100 keV/μm and then decreases with further increase of LET. This has long been interpreted as an excessive energy deposition over the necessary energy required to produce a biologically effective event. Here, we present an alternative interpretation. Cell traversed by a charged particle has certain probability to receive lethal damage leading to direct death. Such events may increase with an increase of LET and the number of charged particles traversing the cell. Assuming that the lethal damage is distributed according to a Poisson distribution, the probability that a cell has no such damage is expressed by e -cLx , where c is a constant, L is LET, and x is the number of charged particles traversing the cell. From these assumptions, the frequency of chromosome aberration in surviving cells can be described by Y=αSD+βS 2 D 2 with the empirical relation Y=αD+βD 2 in the low LET region, where S=e -cL , α is a value proportional to LET, β is a constant, and D is the absorbed dose. This model readily explains the empirically established relationship between LET and relative biological effectiveness (RBE). The model can also be applied to clonogenic survival. If cells can survive and they have neither unstable chromosome aberrations nor other lethal damage, the LET-RBE relationship for clonogenic survival forms a humped curve. The relationship between LET and inactivation cross-section becomes proportional to the square of LET in the low LET region when the frequency of a directly lethal events is sufficiently smaller than unity, and the inactivation cross-section saturates to the cell nucleus cross-sectional area with an increase in LET in the high LET region. (author)

  16. A technique for choosing an option for SDH network upgrade

    Directory of Open Access Journals (Sweden)

    V. A. Bulanov

    2014-01-01

    Full Text Available Rapidly developing data transmission technologies result in making the network equipment modernization inevitable. There are various options to upgrade the SDH networks, for example, by increasing the capacity of network overloaded sites, the entire network capacity by replacement of the equipment or by creation of a parallel network, by changing the network structure with the organization of multilevel hierarchy of a network, etc. All options vary in a diversity of parameters starting with the solution cost and ending with the labor intensiveness of their realization. Thus, there are no certain standard approaches to the rules to choose an option for the network development. The article offers the technique for choosing the SHD network upgrade based on method of expert evaluations using as a tool the software complex that allows us to have quickly the quantitative characteristics of proposed network option. The technique is as follows:1. Forming a perspective matrix of services inclination to the SDH networks.2. Developing the several possible options for a network modernization.3. Formation of the list of criteria and a definition of indicators to characterize them by two groups, namely costs of the option implementation and arising losses; positive effect from the option introduction.4. Criteria weight coefficients purpose.5. Indicators value assessment within each criterion for each option by each expert. Rationing of the obtained values of indicators in relation to the maximum value of an indicator among all options.6. Calculating the integrated indicators of for each option by criteria groups.7. Creating a set of Pareto by drawing two criteria groups of points, which correspond to all options in the system of coordinates on the plane. Option choice.In implementation of point 2 the indicators derivation owing to software complex plays a key role. This complex should produce a structure of the network equipment, types of multiplexer sections

  17. Factors for Choosing a Point of Purchase of Meat Products

    Directory of Open Access Journals (Sweden)

    Martin Souček

    2015-01-01

    Full Text Available This paper is focused on factors influencing consumers when choosing an outlet when shopping for meat products. This issue is very relevant in the Czech Republic as there were a number of problems and affairs in the food industry in the past period. Consumers begin to change their buying habits gradually and focus more on product quality. In the Czech Republic producers specializing in their production of meat products on quality have begun to improve their situation. The research results come from a questionnaire survey conducted in the Czech Republic (n = 1137. The data were processed with Statistica v. 11. Frequency tables, contingency tables and cluster analysis were used for the data analysis. Results show that in the Czech population a strong influence of price as a factor influencing a choice of point of purchase still prevails. Analyses focused on assessment of three hypotheses that were validated through decomposition into sub-hypotheses and application of contingency analysis. Measures of associations were examined in particular in relation to age category of respondents, household income, and level of attained education. In all cases, associations were identified for all three characteristics, the strongest associations were found particularly in the context of respondent’s age. The presented results show that managers of stores selling meat products should pay attention to a demographic structure of their customers and adjust their services and offer to their preferences.

  18. Choosing to regulate: does choice enhance craving regulation?

    Science.gov (United States)

    Mobasser, Arian; Zeithamova, Dagmar; Pfeifer, Jennifer H

    2018-01-01

    Abstract Goal-directed behavior and lifelong well-being often depend on the ability to control appetitive motivations, such as cravings. Cognitive reappraisal is an effective way to modulate emotional states, including cravings, but is often studied under explicit instruction to regulate. Despite the strong prediction from Self-Determination Theory that choice should enhance task engagement and regulation success, little is known empirically about whether and how regulation is different when participants choose (vs are told) to exert control. To investigate how choice affects neural activity and regulation success, participants reappraised their responses to images of personally-craved foods while undergoing functional neuroimaging. Participants were either instructed to view or reappraise (‘no-choice’) or chose freely to view or reappraise (‘yes-choice’). Choice increased activity in the frontoparietal control network. We expected this activity would be associated with increased task engagement, resulting in better regulation success. However, contrary to this prediction, choice slightly reduced regulation success. Follow-up multivariate functional neuroimaging analyses indicated that choice likely disrupted allocation of limited cognitive resources during reappraisal. While unexpected, these results highlight the importance of studying upstream processes such as regulation choice, as they may affect the ability to regulate cravings and other emotional states. PMID:29462475

  19. Choosing the negative: A behavioral demonstration of morbid curiosity

    Science.gov (United States)

    2017-01-01

    This paper examined, with a behavioral paradigm, to what extent people choose to view stimuli that portray death, violence or harm. Based on briefly presented visual cues, participants made choices between highly arousing, negative images and positive or negative alternatives. The negative images displayed social scenes that involved death, violence or harm (e.g., war scene), or decontextualized, close-ups of physical harm (e.g., mutilated face) or natural threat (e.g., attacking shark). The results demonstrated that social negative images were chosen significantly more often than other negative categories. Furthermore, participants preferred social negative images over neutral images. Physical harm images and natural threat images were not preferred over neutral images, but were chosen in about thirty-five percent of the trials. These results were replicated across three different studies, including a study that presented verbal descriptions of images as pre-choice cues. Together, these results show that people deliberately subject themselves to negative images. With this, the present paper demonstrates a dynamic relationship between negative information and behavior and advances new insights into the phenomenon of morbid curiosity. PMID:28683147

  20. Patient choice modelling: how do patients choose their hospitals?

    Science.gov (United States)

    Smith, Honora; Currie, Christine; Chaiwuttisak, Pornpimol; Kyprianou, Andreas

    2018-06-01

    As an aid to predicting future hospital admissions, we compare use of the Multinomial Logit and the Utility Maximising Nested Logit models to describe how patients choose their hospitals. The models are fitted to real data from Derbyshire, United Kingdom, which lists the postcodes of more than 200,000 admissions to six different local hospitals. Both elective and emergency admissions are analysed for this mixed urban/rural area. For characteristics that may affect a patient's choice of hospital, we consider the distance of the patient from the hospital, the number of beds at the hospital and the number of car parking spaces available at the hospital, as well as several statistics publicly available on National Health Service (NHS) websites: an average waiting time, the patient survey score for ward cleanliness, the patient safety score and the inpatient survey score for overall care. The Multinomial Logit model is successfully fitted to the data. Results obtained with the Utility Maximising Nested Logit model show that nesting according to city or town may be invalid for these data; in other words, the choice of hospital does not appear to be preceded by choice of city. In all of the analysis carried out, distance appears to be one of the main influences on a patient's choice of hospital rather than statistics available on the Internet.

  1. Matrix Model for Choosing Green Marketing Sustainable Strategic Alternatives

    Directory of Open Access Journals (Sweden)

    Cătălina Sitnikov

    2015-08-01

    Full Text Available Green marketing examines the symbiotic role played by marketing in ensuring sustainable business, exploring issues concerning the environment and the way strategic decisions can influence it. At present, the environmental issues concern more and more the competitive approach any organization can implement. Based on this approach, organizations can gain competitive advantage by managing environmental variables and by developing and implementing green marketing strategies. Considering the importance and impact of green marketing, by using theoretical concepts and defining a set of research directions, the paper and the research conducted were focused on creating a matrix model for choosing the optimal green marketing strategy, oriented towards competitive advantage. The model is based on the correlation that can be established among the generic strategies of competitive advantage, the variables of extended marketing mix (7Ps and the green marketing strategy matrix. There are also analyzed the implications that may be generated within a company by the adoption of a green marketing strategy and its role in promoting the environmental benefits of products.

  2. Choosing the right journal for your systematic review.

    Science.gov (United States)

    Betini, Marluci; Volpato, Enilze S N; Anastácio, Guilherme D J; de Faria, Renata T B G; El Dib, Regina

    2014-12-01

    The importance of systematic reviews (SRs) as an aid to decision making in health care has led to an increasing interest in the development of this type of study. When selecting a target journal for publication, authors generally seek out higher impact factor journals. This study aimed to determine the percentage of scientific medical journals that publish SRs according to their impact factors (>2.63) and to determine whether those journals require tools that aim to improve SR reporting and meta-analyses. In our cross-sectional study showing how to choose the right journal for a SR, we selected and analysed scientific journals available in a digital library with a minimum Institute for Scientific Information impact factor of 2.63. We analysed 622 scientific journals, 435 (69.94%) of which publish SRs. Of those 435 journals, 135 (21.60%) provide instructions for authors that mention SRs. Three hundred journals (48.34%) do not discuss criteria for article acceptance in the instructions for authors section, but do publish SRs. Only 118 (27.00%) scientific journals require items to be reported in accordance with the specific SR reporting forms. The majority of the journals do not mention the acceptance of SRs in the instructions for authors section. Only a few journals require that SRs meet specific reporting guidelines, making interpretation of their findings across studies challenging. There is no correlation between the impact factor of the journal and its acceptance of SRs for publication. © 2014 John Wiley & Sons, Ltd.

  3. Sanctioning international protection applicants for choosing the country of asylum

    Directory of Open Access Journals (Sweden)

    Polona Mozetič

    2016-06-01

    Full Text Available Major disparities in the regulation and application of international protection exist among EU member states. Therefore, applicants for international protection want to choose the state where they lodge an application. Instead of harmonizing law on international protection, member states sanction applicants for international protection who lodge an application in the preferred member states and not in the one responsible under the Dublin III Regulation. According to the New International Protection Act, implementing EU procedural directive, it may be assumed that an applicant implicitly withdrew her/his application, if s/he left the asylum home without authorisation, and in that case the procedure is discontinued. If an applicant lodges a subsequent application after more than nine months or more than once, her/his application will possibly not be subject of a substantial examination.In order to prevent ”asylum shopping” EU allows for the possibility that some applicants, who would be entitled to refugee status or subsidiary protection, are never granted such protection. However, this is contrary to the principle of non-refoulement as developed in the case-law of the ECtHR and the Constitutional Court of the Republic of Slovenia. Mechanisms that aim to prevent ”asylum shopping” may be contrary to the well-established principles of human rights protection, unfair or unreasonable and affect the most marginalized applicants for international protection.

  4. Choosing Wisely: Opportunities for Improving Value in Cancer Care Delivery?

    Science.gov (United States)

    Rocque, Gabrielle B; Williams, Courtney P; Jackson, Bradford E; Wallace, Audrey S; Halilova, Karina I; Kenzik, Kelly M; Partridge, Edward E; Pisu, Maria

    2017-01-01

    Patients, providers, and payers are striving to identify where value in cancer care can be increased. As part of the Choosing Wisely (CW) campaign, ASCO and the American Society for Therapeutic Radiology and Oncology have recommended against specific, yet commonly performed, treatments and procedures. We conducted a retrospective analysis of Medicare claims data to examine concordance with CW recommendations across 12 cancer centers in the southeastern United States. Variability for each measure was evaluated on the basis of patient characteristics and site of care. Hierarchical linear modeling was used to examine differences in average costs per patient by concordance status. Potential cost savings were estimated on the basis of a potential 95% adherence rate and average cost difference. The analysis included 37,686 patients with cancer with Fee-for-Service Medicare insurance. Concordance varied by CW recommendation from 39% to 94%. Patient characteristics were similar for patients receiving concordant and nonconcordant care. Significant variability was noted across centers for all recommendations, with as much as an 89% difference. Nonconcordance was associated with higher costs for every measure. If concordance were to increase to 95% for all measures, we would estimate a $19 million difference in total cost of care per quarter. These results demonstrate ample room for reduction of low-value care and corresponding costs associated with the CW recommendations. Because variability in concordance was driven primarily by site of care, rather than by patient factors, continued education about these low-value services is needed to improve the value of cancer care.

  5. Rejecting a bad option feels like choosing a good one.

    Science.gov (United States)

    Perfecto, Hannah; Galak, Jeff; Simmons, Joseph P; Nelson, Leif D

    2017-11-01

    Across 4,151 participants, the authors demonstrate a novel framing effect, attribute matching, whereby matching a salient attribute of a decision frame with that of a decision's options facilitates decision-making. This attribute matching is shown to increase decision confidence and, ultimately, consensus estimates by increasing feelings of metacognitive ease. In Study 1, participants choosing the more attractive of two faces or rejecting the less attractive face reported greater confidence in and perceived consensus around their decision. Using positive and negative words, Study 2 showed that the attribute's extremity moderates the size of the effect. Study 3 found decision ease mediates these changes in confidence and consensus estimates. Consistent with a misattribution account, when participants were warned about this external source of ease in Study 4, the effect disappeared. Study 5 extended attribute matching beyond valence to objective judgments. The authors conclude by discussing related psychological constructs as well as downstream consequences. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  6. Trends in characteristics of women choosing contraindicated home births.

    Science.gov (United States)

    Zafman, Kelly B; Stone, Joanne L; Factor, Stephanie H

    2018-04-12

    To characterize the American College of Obstetricians and Gynecologists (ACOG) contraindicated home births and the women who are receiving these births in hopes of identifying venues for intervention. The National Center for Health Statistics (NCHS) birth certificate records from 1990 to 2015 were used. "Planned home births" were defined as those births in which birthplace was coded as "residence" and birth attendant was coded as "certified nurse midwife (CNM)" or "other midwife". Contraindicated home births were defined as "planned home births" from 1990 to 2015 that had one or more of the ACOG risk factors for home births, which include vaginal birth after prior cesarean delivery (VBAC), breech presentation and multiple gestations. A review of trends in contraindicated home births from 1990 to 2015 suggests that they are increasing in number (481-1396) and as a percentage of total births (0.01%-0.04%, P95%), which is most frequently initiated in the first trimester. The majority of home births were paid out-of-pocket (65%-69%). The increasing number of contraindicated home births in the United States requires public health action. Home births are likely a matter of choice rather than a lack of resources. It is unclear if women choose home births while knowing the risk or due to a lack of information. Prenatal education about contraindicated home births is possible, as almost all women receive prenatal care.

  7. Oral desensitization to milk: how to choose the starting dose!

    Science.gov (United States)

    Mori, Francesca; Pucci, Neri; Rossi, Maria Elisabetta; de Martino, Maurizio; Azzari, Chiara; Novembre, Elio

    2010-01-01

    Mori F, Pucci N, Rossi ME, de Martino M, Azzari C, Novembre E. Oral desensitization to milk: how to choose the starting dose! Pediatr Allergy Immunol 2010: 21: e450–e453. © 2009 John Wiley & Sons A/S A renewed interest in oral desensitization as treatment for food allergy has been observed in the last few years. We studied a novel method based on the end point skin prick test procedure to establish the starting dose for oral desensitization in a group of 30 children higly allergic to milk. The results (in terms of reactions to the first dose administered) were compared with a group of 20 children allergic to milk as well. Such control group started to swallow the same dose of 0.015 mg/ml of milk. None reacted to the first dose when administered according to the end point skin prick test. On the other side, ten out of 20 children (50%) from the control group showed mild allergic reactions to the first dose of milk. In conclusion the end point skin prick test procedure results safe and easy to be performed in each single child in order to find out the starting dose for oral desensitization to milk, also by taking into account the individual variability. PMID:19624618

  8. Evaluating rodent motor functions: Which tests to choose?

    Science.gov (United States)

    Schönfeld, Lisa-Maria; Dooley, Dearbhaile; Jahanshahi, Ali; Temel, Yasin; Hendrix, Sven

    2017-12-01

    Damage to the motor cortex induced by stroke or traumatic brain injury (TBI) can result in chronic motor deficits. For the development and improvement of therapies, animal models which possess symptoms comparable to the clinical population are used. However, the use of experimental animals raises valid ethical and methodological concerns. To decrease discomfort by experimental procedures and to increase the quality of results, non-invasive and sensitive rodent motor tests are needed. A broad variety of rodent motor tests are available to determine deficits after stroke or TBI. The current review describes and evaluates motor tests that fall into three categories: Tests to evaluate fine motor skills and grip strength, tests for gait and inter-limb coordination and neurological deficit scores. In this review, we share our thoughts on standardized data presentation to increase data comparability between studies. We also critically evaluate current methods and provide recommendations for choosing the best behavioral test for a new research line. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. When I cut, you choose method implies intransitivity

    Science.gov (United States)

    Makowski, Marcin; Piotrowski, Edward W.

    2014-12-01

    There is a common belief that humans and many animals follow transitive inference (choosing A over C on the basis of knowing that A is better than B and B is better than C). Transitivity seems to be the essence of rational choice. We present a theoretical model of a repeated game in which the players make a choice between three goods (e.g. food). The rules of the game refer to the simple procedure of fair division among two players, known as the “I cut, you choose” mechanism which has been widely discussed in the literature. In this game one of the players has to make intransitive choices in order to achieve the optimal result (for him/her and his/her co-player). The point is that an intransitive choice can be rational. Previously, an increase in the significance of intransitive strategies was achieved by referring to models of quantum games. We show that relevant intransitive strategies also appear in the classic description of decision algorithms.

  10. Review of relative biological effectiveness dependence on linear energy transfer for low-LET radiations

    International Nuclear Information System (INIS)

    Hunter, Nezahat; Muirhead, Colin R

    2009-01-01

    Information on Japanese A-bomb survivors exposed to gamma radiation has been used to estimate cancer risks for the whole range of photon (x-rays) and electron energies which are commonly encountered by radiation workers in the work place or by patients and workers in diagnostic radiology. However, there is some uncertainty regarding the radiation effectiveness of various low-linear energy transfer (low-LET) radiations (x-rays, gamma radiation and electrons). In this paper we review information on the effectiveness of low-LET radiations on the basis of epidemiological and in vitro radiobiological studies. Data from various experimental studies for chromosome aberrations and cell transformation in human lymphocytes and from epidemiological studies of the Japanese A-bomb survivors, patients medically exposed to radiation for diagnostic and therapeutic procedures, and occupational exposures of nuclear workers are considered. On the basis of in vitro cellular radiobiology, there is considerable evidence that the relative biological effectiveness (RBE) of high-energy low-LET radiation (gamma radiation, electrons) is less than that of low-energy low-LET radiation (x-rays, betas). This is a factor of about 3 to 4 for 29 kVp x-rays (e.g. as in diagnostic radiation exposures of the female breast) and for tritium beta-rays (encountered in parts of the nuclear industry) relative to Co-60 gamma radiation and 2-5 MeV gamma-rays (as received by the Japanese A-bomb survivors). In epidemiological studies, although for thyroid and breast cancer there appears to be a small tendency for the excess relative risks to decrease as the radiation energy increases for low-LET radiations, it is not statistically feasible to draw any conclusion regarding an underlying dependence of cancer risk on LET for the nominally low-LET radiations. (review)

  11. Let-7b-mediated suppression of basigin expression and metastasis in mouse melanoma cells

    International Nuclear Information System (INIS)

    Fu, Tzu-Yen; Chang, Chia-Che; Lin, Chun-Ting; Lai, Cong-Hao; Peng, Shao-Yu; Ko, Yi-Ju; Tang, Pin-Chi

    2011-01-01

    Basigin (Bsg), also called extracellular matrix metalloproteinase inducer (EMMPRIN), is highly expressed on the surface of tumor cells and stimulates adjacent fibroblasts or tumor cells to produce matrix metalloproteinases (mmps). It has been shown that Bsg plays an important role in growth, development, cell differentiation, and tumor progression. MicroRNAs (miRNAs) are a class of short endogenous non-protein coding RNAs of 20-25 nucleotides (nt) that function as post-transcriptional regulators of gene expression by base-pairing to their target mRNAs and thereby mediate cleavage of target mRNAs or translational repression. In this study, let-7b, one of the let-7 family members, was investigated for its effect on the growth and invasiveness of the mouse melanoma cell line B16-F10. We have shown that let-7b can suppress the expression of Bsg in B16-F10 cells and also provided evidence that this suppression could result in the indirect suppression of mmp-9. The ability of B16-F10 cells transfected with let-7b to invade or migrate was significantly reduced. In addition, let-7b transfected B16-F10 cells displayed an inhibition of both cellular proliferation and colony formation. Furthermore, it was shown that the overexpression of let-7b in B16-F10 cells could reduce lung metastasis. Taken together, the present study identifies let-7b as a tumor suppressor that represses cancer cell proliferation and migration as well as tumor metastasis in mouse melanoma cells.

  12. Let-7b-mediated suppression of basigin expression and metastasis in mouse melanoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Tzu-Yen [Department of Animal Science, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Chang, Chia-Che [Institute of Biomedical Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Graduate Institute of Basic Medical Science, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan (China); Lin, Chun-Ting [Department of Animal Science, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Lai, Cong-Hao [Institute of Biomedical Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Department of Life Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Peng, Shao-Yu; Ko, Yi-Ju [Department of Animal Science, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Tang, Pin-Chi, E-mail: pctang@dragon.nchu.edu.tw [Department of Animal Science, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China)

    2011-02-15

    Basigin (Bsg), also called extracellular matrix metalloproteinase inducer (EMMPRIN), is highly expressed on the surface of tumor cells and stimulates adjacent fibroblasts or tumor cells to produce matrix metalloproteinases (mmps). It has been shown that Bsg plays an important role in growth, development, cell differentiation, and tumor progression. MicroRNAs (miRNAs) are a class of short endogenous non-protein coding RNAs of 20-25 nucleotides (nt) that function as post-transcriptional regulators of gene expression by base-pairing to their target mRNAs and thereby mediate cleavage of target mRNAs or translational repression. In this study, let-7b, one of the let-7 family members, was investigated for its effect on the growth and invasiveness of the mouse melanoma cell line B16-F10. We have shown that let-7b can suppress the expression of Bsg in B16-F10 cells and also provided evidence that this suppression could result in the indirect suppression of mmp-9. The ability of B16-F10 cells transfected with let-7b to invade or migrate was significantly reduced. In addition, let-7b transfected B16-F10 cells displayed an inhibition of both cellular proliferation and colony formation. Furthermore, it was shown that the overexpression of let-7b in B16-F10 cells could reduce lung metastasis. Taken together, the present study identifies let-7b as a tumor suppressor that represses cancer cell proliferation and migration as well as tumor metastasis in mouse melanoma cells.

  13. High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation

    International Nuclear Information System (INIS)

    Yamakawa, Nobuhiro; Takahashi, Akihisa; Mori, Eiichiro; Imai, Yuichiro; Ohnishi, Ken; Kirita, Tadaaki; Ohnishi, Takeo; Furusawa, Yoshiya

    2008-01-01

    Although mutations in the p53 gene can lead to resistance to radiotherapy, chemotherapy and thermotherapy, high linear energy transfer (LET) radiation induces apoptosis regardless of p53 gene status in cancer cells. The aim of this study was to clarify the mechanisms involved in high LET radiation-induced apoptosis. Human gingival cancer cells (Ca9-22 cells) containing a mutated p53 (mp53) gene were irradiated with X-rays, C-ion (13-100 KeV/μm), or Fe-ion beams (200 KeV/μm). Cellular sensitivities were determined using colony forming assays. Apoptosis was detected and quantified with Hoechst 33342 staining. The activity of Caspase-3 was analyzed with Western blotting and flow cytometry. Cells irradiated with high LET radiation showed a high sensitivity with a high frequency of apoptosis induction. The relative biological effectiveness (RBE) values for the surviving fraction and apoptosis induction increased in a LET-dependent manner. Both RBE curves reached a peak at 100 KeV/μm, and then decreased at values over 100 KeV/μm. When cells were irradiated with high LET radiation, Caspase-3 was cleaved and activated, leading to poly (ADP-ribose) polymerase (PARP) cleavage. In addition, Caspase-9 inhibitor suppressed Caspase-3 activation and apoptosis induction resulting from high LET radiation to a greater extent than Caspase-8 inhibitor. These results suggest that high LET radiation enhances apoptosis by activation of Caspase-3 through Caspase-9, even in the presence of mp53. (author)

  14. Experimental and calculated LET distributions in the Cosmos-2044 biosatellite orbit

    International Nuclear Information System (INIS)

    Dudkin, V.E.; Karpov, O.N.; Potapov, Yu.V.; Benton, E.V.; Frank, A.L.; Watts, J.W. Jr.

    1992-01-01

    During the flight of the Cosmos-2044 biosatellite, joint U.S.S.R.-U.S.A. investigations of different characteristics of cosmic radiation (CR) in the near-Earth environment were carried out. The U.S. dielectric track detectors CR-39 and Soviet BYa- and BR-type nuclear photo-emulsions were used as detectors. The present work shows some results of experimental measurements of linear energy transfer (LET) spectra of CR particles obtained with the use of these detectors, which were placed both inside and outside the satellite. The LET spectra measurement with plastic detectors is composed of two parts: the measurement of galactic cosmic rays (GCR) particles, and of short-range particles. The contributions of these components to the total LET distribution at various thicknesses of the shielding were analyzed and the results of these studies are presented. Calculated LET spectra in the Cosmos-2044 orbit were compared with experimental data. On the basis of experimental and calculated values of the LET spectra, absorbed and equivalent CR doses were calculated. In the shielding range of 1-1.5 g cm -2 , outside the spacecraft, the photo-emulsions yielded 10.3 mrad d -1 and 27.5 mrem d -1 (LET ≥ 2 MeV cm -1 ) while the CR-39 yielded averages of 1.43 mrad d -1 and 13.4 mrem d -1 (LET ≥ 40 MeV cm -1 ). Inside the spacecraft (≥10 g cm -2 ) the photo-emulsions yielded 8.9 mrad d -1 and 14.5 mrem d -1 . (author)

  15. VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation

    International Nuclear Information System (INIS)

    Fujisawa, Hiroshi; Nakajima, Nakako Izumi; Sunada, Shigeaki; Lee, Younghyun; Hirakawa, Hirokazu; Yajima, Hirohiko; Fujimori, Akira; Uesaka, Mitsuru; Okayasu, Ryuichi

    2015-01-01

    High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The reason why high LET radiation accomplishes greater tumor-killing than X-rays is still not completely understood. One factor would be the clustered or complex-type DNA damages. We previously reported that complex DNA double-strand breaks produced by high LET radiation enhanced DNA end resection, and this could lead to higher kinase activity of ATR protein recruited to RPA-coated single-stranded DNA. Although the effect of ATR inhibition on cells exposed to low LET gamma-rays has recently been reported, little is known regarding the effect of ATR inhibitor on cells treated with high LET radiation. The purpose of this study is to investigate the effects of the ATR inhibitor VE-821 in human tumor and normal cells irradiated with high LET carbon ions. HeLa, U2OS, and 1BR-hTERT (normal) cells were pre-treated with 1 μM VE-821 for 1 hour and irradiated with either high LET carbon ions or X-rays. Cell survival, cell cycle distribution, cell growth, and micronuclei formation were evaluated. VE-821 caused abrogation of G2/M checkpoint and forced irradiated cells to divide into daughter cells. We also found that carbon ions caused a higher number of multiple micronuclei than X-rays, leading to decreased cell survival in tumor cells when treated with VE-821, while the survival of irradiated normal cells were not significantly affected by this inhibitor. ATR inhibitor would be an effective tumor radiosensitizer with carbon ion irradiation. The online version of this article (doi:10.1186/s13014-015-0464-y) contains supplementary material, which is available to authorized users

  16. Let-7a is a direct EWS-FLI-1 target implicated in Ewing's sarcoma development.

    Directory of Open Access Journals (Sweden)

    Claudio De Vito

    Full Text Available Ewing's sarcoma family tumors (ESFT are the second most common bone malignancy in children and young adults, characterized by unique chromosomal translocations that in 85% of cases lead to expression of the EWS-FLI-1 fusion protein. EWS-FLI-1 functions as an aberrant transcription factor that can both induce and suppress members of its target gene repertoire. We have recently demonstrated that EWS-FLI-1 can alter microRNA (miRNA expression and that miRNA145 is a direct EWS-FLI-1 target whose suppression is implicated in ESFT development. Here, we use miRNA arrays to compare the global miRNA expression profile of human mesenchymal stem cells (MSC and ESFT cell lines, and show that ESFT display a distinct miRNA signature that includes induction of the oncogenic miRNA 17-92 cluster and repression of the tumor suppressor let-7 family. We demonstrate that direct repression of let-7a by EWS-FLI-1 participates in the tumorigenic potential of ESFT cells in vivo. The mechanism whereby let-7a expression regulates ESFT growth is shown to be mediated by its target gene HMGA2, as let-7a overexpression and HMGA2 repression both block ESFT cell tumorigenicity. Consistent with these observations, systemic delivery of synthetic let-7a into ESFT-bearing mice restored its expression in tumor cells, decreased HMGA2 expression levels and resulted in ESFT growth inhibition in vivo. Our observations provide evidence that deregulation of let-7a target gene expression participates in ESFT development and identify let-7a as promising new therapeutic target for one of the most aggressive pediatric malignancies.

  17. Who chooses to become a teacher and why?

    DEFF Research Database (Denmark)

    Reimer, David; Dorf, Hans

    -secondary pupils. The nature of the data collected enables us to characterize teacher education students in contrast to a baseline reference group eligible to apply for teacher education and to compare these differences across countries (difference-in-differences estimation). This analytical strategy allows us......We analyze in this article to what extent beginning teacher education students at the primary school level differ with respect to previous educational pathways, socio-demographic characteristics, academic self-concepts and occupational motivations. In order to overcome methodological problems...... of most previous empirical studies on teacher recruitment we draw on data from a recent comparative study on teacher recruitment based on two different samples: In both Denmark and Finland we surveyed a representative group of first year teacher education students as well as last year upper...

  18. Generational differences in factors influencing physicians to choose a work location.

    Science.gov (United States)

    Mathews, M; Seguin, M; Chowdhury, N; Card, R T

    2012-01-01

    Canadian medical schools have increased enrolment and recruited more rural students in an effort to address general and rural physician shortages. The success of this approach depends on the recruitment of these newly trained physicians to under-serviced areas. Studies from North America suggest that the career expectations and practice patterns of younger, more recently graduated physicians differ from those of their older counterparts. This study explored the factors that influenced the work location choices of physicians of differing generations, who trained at universities in Saskatchewan, and Newfoundland and Labrador, two Canadian provinces with large rural populations and no community larger than 235 000 population. Semi-structured, qualitative interviews were conducted with physicians who graduated from either the Memorial University of Newfoundland or the University of Saskatchewan. Generation definitions were based on the graduation year. Early-career physicians graduated between 1995 and 1999; mid-career physician graduated between 1985 and 1989; late-career physicians graduated between 1975 and 1979; and end-career physicians graduated between 1965 and 1969. Each physician was asked questions about the number and nature of work location changes over the course of their careers and the factors related to their decision to choose each location. Interview transcripts and notes were analyzed using a thematic analysis approach. Although the study focus was on generational differences, similarities and differences between universities, sexes and specialties (family physicians/GPs vs specialists) were also examined. Recruitment to the provinces was focused on as a whole, because the largest communities in the provinces are small compared with most urban communities. Forty-eight physicians were interviewed, five to nine physicians who graduated in each decade and from each university. The desire to be near family and friends was cited as the primary

  19. The Influence of Cultural Social Identity on Graduate Student Career Choice

    Science.gov (United States)

    Haley, Karen J.; Jaeger, Audrey J.; Levin, John S.

    2014-01-01

    This study examines and enriches understanding of the career choice process for graduate students of color. Social identity theory (SIT) is used as a framework to expand our understanding of how and why graduate students choose (or do not choose) faculty careers. Graduate students' cultural social identities influenced their career choice…

  20. What's Next? Planning and Financing Your Post-Secondary Education. Revised. Students Finance. Study Your Options.

    Science.gov (United States)

    Alberta Learning, Edmonton.

    This guide is designed to help students in Alberta, Canada, plan and finance postsecondary education. A student who has made financial plans will have more options when it is time to choose an institution for postsecondary education. How to choose the right school depends on what a student wants from education and what he or she plans for the…

  1. What's Next? Planning and Financing Your Post-Secondary Education. Students Finance. Study your Options. Revised.

    Science.gov (United States)

    Human Resources Development Canada, Ottawa (Ontario).

    This updated guide is designed to help students in Alberta, Canada, plan and finance postsecondary education. A student who has made financial plans will have more options when it is time to choose an institution for postsecondary education. How to choose the right school depends on what a student wants from education and what he or she plans for…

  2. Characterization and expression patterns of let-7 microRNA in the silkworm (Bombyx mori

    Directory of Open Access Journals (Sweden)

    Hong Kaili

    2007-07-01

    Full Text Available Abstract Background lin-4 and let-7, the two founding members of heterochronic microRNA genes, are firstly confirmed in Caenorhabditis elegans to control the proper timing of developmental programs in a heterochronic pathway. let-7 has been thought to trigger the onset of adulthood across animal phyla. Ecdysone and Broad-Complex are required for the temporal expression of let-7 in Drosophila melanogaster. For a better understanding of the conservation and functions of let-7, we seek to explore how it is expressed in the silkworm (Bombyx mori. Results One member of let-7 family has been identified in silkworm computationally and experimentally. All known members of this family share the same nucleotides at ten positions within the mature sequences. Sequence logo and phylogenetic tree show that they are not only conserved but diversify to some extent among some species. The bmo-let-7 was very lowly expressed in ova harvested from newborn unmated female adult and in individuals from the first molt to the early third instar, highly expressed after the third molt, and the most abundant expression was observed after mounting, particularly after pupation. The expression levels were higher at the end of each instar and at the beginning of each molt than at other periods, coinciding with the pulse of ecdysone and BR-C as a whole. Using cultured ovary cell line, BmN-SWU1, we examined the effect of altered ecdysone levels on bmo-let-7 expression. The expression was also detected in various tissues of day 3 of the fifth instar and of from day 7 of the fifth to pupa, suggesting a wide distributing pattern with various signal intensities. Conclusion bmo-let-7 is stage- and tissue-specifically expressed in the silkworm. Although no signals were detected during embryonic development and first larval instar stages, the expression of bmo-let-7 was observed from the first molt, suggesting that it might also function at early larval stage of the silkworm. The

  3. Characterization and expression patterns of let-7 microRNA in the silkworm (Bombyx mori).

    Science.gov (United States)

    Liu, Shiping; Xia, Qingyou; Zhao, Ping; Cheng, Tingcai; Hong, Kaili; Xiang, Zhonghuai

    2007-07-25

    lin-4 and let-7, the two founding members of heterochronic microRNA genes, are firstly confirmed in Caenorhabditis elegans to control the proper timing of developmental programs in a heterochronic pathway. let-7 has been thought to trigger the onset of adulthood across animal phyla. Ecdysone and Broad-Complex are required for the temporal expression of let-7 in Drosophila melanogaster. For a better understanding of the conservation and functions of let-7, we seek to explore how it is expressed in the silkworm (Bombyx mori). One member of let-7 family has been identified in silkworm computationally and experimentally. All known members of this family share the same nucleotides at ten positions within the mature sequences. Sequence logo and phylogenetic tree show that they are not only conserved but diversify to some extent among some species. The bmo-let-7 was very lowly expressed in ova harvested from newborn unmated female adult and in individuals from the first molt to the early third instar, highly expressed after the third molt, and the most abundant expression was observed after mounting, particularly after pupation. The expression levels were higher at the end of each instar and at the beginning of each molt than at other periods, coinciding with the pulse of ecdysone and BR-C as a whole. Using cultured ovary cell line, BmN-SWU1, we examined the effect of altered ecdysone levels on bmo-let-7 expression. The expression was also detected in various tissues of day 3 of the fifth instar and of from day 7 of the fifth to pupa, suggesting a wide distributing pattern with various signal intensities. bmo-let-7 is stage- and tissue-specifically expressed in the silkworm. Although no signals were detected during embryonic development and first larval instar stages, the expression of bmo-let-7 was observed from the first molt, suggesting that it might also function at early larval stage of the silkworm. The detailed expression profiles in the whole life cycle and

  4. Choosing to Fly: Examining Fear, Risk and Resilience

    KAUST Repository

    Davis, Steph

    2017-01-01

    Steph Davis was raised as a classical piano student in a traditional, academic family. She ultimately quit music and then law school, making the frightening decision to step off the safe road and follow her passion to become a full-time rock

  5. Choosing is feeling - the cognitive neuroscience of decision making.

    NARCIS (Netherlands)

    Kalenscher, T.

    2007-01-01

    Why do we often know exactly what we should do, but end up doing something completely different? For example, how many times were you supposed to study an important article, but read the latest thrilling crime novel instead? How often did you miss a lecture when you were a student because you were

  6. The Teaching of Educational Psychology 1973: Freedom to Choose.

    Science.gov (United States)

    Ripple, Richard E.

    In response to renewed interest in undergraduate instruction and to the undergraduate's participation in a humanistic revolt against depersonalization and "scientism," a new educational psychology course has been instituted at Cornell. The 100 to 150 students of varying purposes and interests who enroll in the course are not a coherent group…

  7. Best Practices and Processes for Choosing Research Priorities

    Science.gov (United States)

    Briscoe, M. G.

    2015-12-01

    Individuals, teams, departments, organizations, funding agencies, committees, and others all need to select desirable research priorities from many possible alternatives. One cannot do everything, one cannot afford everything, so what to select? Essays and reports since Weinberg (1963) have suggested criteria for choosing science topics. Popper et al (2000) reviewed and summarized all that had gone before in the subject of setting priorities; their main conclusions were that the underlying principles were the promotion of excellence and relevance. Sea Change (2015) from the NRC/OSB focused on four criteria. From most important to least important, they were transformative science, societal impacts, readiness, and partnership potential; these four criteria embodied the essence of the suggestions from Weinberg on, framed with the pragmatism of ORPISS (2007). Getting to the final set of priorities from many candidates involves a sequence of formal or informal processes, only the last of which is the application of the selected, weighted criteria. As developed by professional prioritization experts, the best-practice steps and processes are: Collection of input candidates from the community. Clustering and parsing/rephrasing of the input to eliminate redundancy and repetition and develop statements at a useful level of specificity. (NOTE:there is no counting of input to see how many times a particular topic was mentioned. The goal is diversity in the input, not a popularity contest.) Development of the selection criteria, and weighting the chosen criteria. Application of the selection criteria to the clustered/adjusted candidates. Finally, two more best practices: Do continuing sanity checks, to avoid losing sight of the goals of the effort. Resist the temptation to just sit around a table and talk about it to arrive at the priorities, which depends too much on who the specific members of the prioritization team are, and provides no transparency or explanation of why

  8. Consumer Behavior Modeling: Fuzzy Logic Model for Air Purifiers Choosing

    Directory of Open Access Journals (Sweden)

    Oleksandr Dorokhov

    2017-12-01

    Full Text Available At the beginning, the article briefly describes the features of the marketing complex household goods. Also provides an overview of some aspects of the market for indoor air purifiers. The specific subject of the study was the process of consumer choice of household appliances for cleaning air in living quarters. The aim of the study was to substantiate and develop a computer model for evaluating by the potential buyers devices for air purification in conditions of vagueness and ambiguity of their consumer preferences. Accordingly, the main consumer criteria are identified, substantiated and described when buyers choose air purifiers. As methods of research, approaches based on fuzzy logic, fuzzy sets theory and fuzzy modeling were chosen. It was hypothesized that the fuzzy-multiple model allows rather accurately reflect consumer preferences and potential consumer choice in conditions of insufficient and undetermined information. Further, a computer model for estimating the consumer qualities of air cleaners by customers is developed. A proposed approach based on the application of fuzzy logic theory and practical modeling in the specialized computer software MATLAB. In this model, the necessary membership functions and their terms are constructed, as well as a set of rules for fuzzy inference to make decisions on the estimation of a specific air purifier. A numerical example of a comparative evaluation of air cleaners presented on the Ukrainian market is made and is given. Numerical simulation results confirmed the applicability of the proposed approach and the correctness of the hypothesis advanced about the possibility of modeling consumer behavior using fuzzy logic. The analysis of the obtained results is carried out and the prospects of application, development, and improvement of the developed model and the proposed approach are determined.

  9. Let7a involves in neural stem cell differentiation relating with TLX level.

    Science.gov (United States)

    Song, Juhyun; Cho, Kyoung Joo; Oh, Yumi; Lee, Jong Eun

    2015-07-10

    Neural stem cells (NSCs) have the potential for differentiation into neurons known as a groundbreaking therapeutic solution for central nervous system (CNS) diseases. To resolve the therapeutic efficiency of NSCs, recent researchers have focused on the study on microRNA's role in CNS. Some micro RNAs have been reported significant functions in NSC self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. MicroRNA-Let7a (Let7a) has known as the regulator of diverse cellular mechanisms including cell differentiation and proliferation. In present study, we investigated whether Let7a regulates NSC differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal, proliferation and differentiation. We performed the following experiments: western blot analysis, TaqMan assay, RT-PCR, and immunocytochemistry to confirm the alteration of NSCs. Our data showed that let7a play important roles in controlling NSC fate determination. Thus, manipulating Let-7A and TLX could be a novel strategy to enhance the efficiency of NSC's neuronal differentiation for CNS disorders. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Mutational influences of low-dose and high let ionizing radiation in drosophila melanogaster

    Science.gov (United States)

    Lei, Huang; Fanjun, Kong; Sun, Yeqing

    For cosmic environment consists of a varying kinds of radiation particles including high Z and energy ions which was charactered with low-dose and high RBE, it is important to determine the possible biofuctions of high LET radiation on human beings. To analyse the possible effectes of mutational influences of low-dose and high-LET ionizing radiation, wild fruit flies drosophila melanogaster were irradiated by 12C6+ ions in two LET levels (63.3 and 30 keV/µum) with different low doses from 2mGy to 2000mGy (2, 20, 200, 2000mGy) in HIRFL (Heavy ion radiation facility laboratory, lanzhou, China).In the same LET value group, the average polymorphic frequency was elevated along with adding doses of irradation, the frequency in 2000 mGy dose samples was significantly higher than other samples (p<0.01).These results suggest that genomic DNA sequence could be effected by low-dose and high-LET ionizing radiation, the irradiation dose is an important element in genomic mutation frequency origination.

  11. Keep it local (and final): Remnant preferences in "let alone" ellipsis.

    Science.gov (United States)

    Harris, Jesse A; Carlson, Katy

    2016-01-01

    The let alone construction (John can't run a mile, let alone a marathon) differs from standard coordination structures (with and or but) by requiring ellipsis of the second conjunct--for example, a marathon is the remnant of an elided clause [[see text] a marathon]. In support of an ellipsis account, a corpus study of British and American English finds that let alone exhibits a Locality bias, as the second conjunct preferentially contrasts with the nearest lexical item of the same syntactic type. Two self-paced reading studies show that the Locality bias is active during online processing, but must be reconciled with indicators of semantic contrast and discourse information. Further, a sentence-rating study shows that the Locality bias interacts with a Finality bias that favours placing the let alone phrase at the end of a clause, which sometimes necessitates a nonlocal contrast. Together, the results show how a general bias in ellipsis for local contrasts is affected by discourse demands, such as the need for scalar contrast imposed by let alone, thereby offering a window into how possibly divergent syntactic and discourse constraints impact sentence processing.

  12. Keep it local (and final): Remnant preferences in ‘let alone’ ellipsis

    Science.gov (United States)

    Harris, Jesse A.; Carlson, Katy

    2015-01-01

    The let alone construction (John can't run a mile, let alone a marathon) differs from standard coordination structures (with and or but) by requiring ellipsis of the second conjunct, e.g., a marathon is the remnant of an elided clause [John run a marathon]. In support of an ellipsis account, a corpus study of British and American English finds that let alone exhibits a Locality bias, as the second conjunct preferentially contrasts with the nearest lexical item of the same syntactic type. Two self-paced reading studies show that the Locality bias is active during online processing, but must be reconciled with indicators of semantic contrast and discourse information. Further, a sentence-rating study shows that the Locality bias interacts with a Finality bias that favors placing the let alone phrase at the end of a clause, which sometimes necessitates a non-local contrast. Together, the results show how a general bias in ellipsis for local contrasts is affected by discourse demands, such as the need for scalar contrast imposed by let alone, thereby offering a window into how possibly divergent syntactic and discourse constraints impact sentence processing. PMID:26085004

  13. Effects of let-7b and TLX on the proliferation and differentiation of retinal progenitor cells in vitro.

    Science.gov (United States)

    Ni, Ni; Zhang, Dandan; Xie, Qing; Chen, Junzhao; Wang, Zi; Deng, Yuan; Wen, Xuyang; Zhu, Mengyu; Ji, Jing; Fan, Xianqun; Luo, Min; Gu, Ping

    2014-10-20

    MicroRNAs manifest significant functions in brain neural stem cell (NSC) self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. Let-7b is expressed in the mammalian brain and regulates NSC proliferation and differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal. Whether let-7b and TLX act as important regulators in retinal progenitor cell (RPC) proliferation and differentiation remains unknown. Here, our data show that let-7b and TLX play important roles in controlling RPC fate determination in vitro. Let-7b suppresses TLX expression to negatively regulate RPC proliferation and accelerate the neuronal and glial differentiation of RPCs. The overexpression of let-7b downregulates TLX levels in RPCs, leading to reduced RPC proliferation and increased neuronal and glial differentiation, whereas antisense knockdown of let-7b produces robust TLX expression,enhanced RPC proliferation and decreased differentiation. Moreover, the inhibition of endogenous TLX by small interfering RNA suppresses RPC proliferation and promotes RPC differentiation. Furthermore, overexpression of TLX rescues let-7b-induced proliferation deficiency and weakens the RPC differentiation enhancement caused by let-7b alone. These results suggest that let-7b, by forming a negative feedback loop with TLX, provides a novel model to regulate the proliferation and differentiation of retinal progenitors in vitro.

  14. Analyzing Trouble on Ethics of Choosing Occupation about Contemporary College graduates and Enlightenment of Marx'view of Choosing Occupation%当代大学生择业伦理的困境分析与马克思择业观的启示

    Institute of Scientific and Technical Information of China (English)

    涂平荣

    2012-01-01

    Under the Sociology background of a difficult employment situation intensified, contemporary college students ' words and deeds in choosing occupation have shown trouble on ethics of choosing occupation such as serious utility tendency in employment expectation occupational value more self-centered perceptual career orientation secular employment idea Lack of employment integrity. To investigate their reason, the author thinks there are not any deep objective factors of the sociology and school, but also college students' personal subjective components. But Marx discussed detailed and insightfully employment attitude of youth, the main factors should be considered, main principles and basic principle of career theory in "the consideration on the choice of occupation for youth". From interpretation of those view on choosing occupations, some appropriate countermeasures can be mined and combed to resolve the above trouble on ethics of choosing occupation: namely, choosing occupations serious and carefully, got out of the utilitarian errors of choosing occupation ethics; understanding myself correctly, removing perceptual color of choosing occupation ethics; firming career beliefs, changing secular concept on choosing occupation ethics; establishing high occupation ideal, criticize malpractice of individualistic choosing occupation ethics.%在就业难愈演愈烈的社会背景下,当代大学生的择业言行已表现出择业期望功利倾向严重、择业价值以自我为中心、择业定位感性、择业观念世俗、择业诚信缺失等择业伦理困境。究其成因,既有社会与学校深层次的客观因素,也有大学生个人的主观成分。马克思在《青年在选择职业时的考虑》一文中详尽而精辟地论述了青年择业时的态度、应考虑的主要因素、主要原则与基本方针,可为化解上述择业伦理困境提供相应对策:严肃认真择业,走出择业伦理的功利误区;正确认识自我,清除

  15. Let's Get Physical: Teaching Physics through Gymnastics

    Science.gov (United States)

    Sojourner, Elena J.; Burgasser, Adam J.; Weise, Eric D.

    2018-01-01

    The concept of embodied learning--that we can learn with our bodies and with our minds--is a well-established concept in physics and math education research, and includes symbolic understanding (e.g., gestures that track how students think or facilitate learning to model complex systems of energy flow) as well as the literal experience of…

  16. The Techy Teacher/Access: Let's Get Creative

    Science.gov (United States)

    Tucker, Catlin

    2016-01-01

    Some teachers fear that using technology will create an even larger divide between the haves and the have nots, but the reality is that kids "must" leave schools technology literate to access information and opportunities beyond school. Teachers who do not have easy access to technology must get creative to give students opportunities to…

  17. Mobile: Letting Go of the Device and Building for Innovation

    Science.gov (United States)

    Davis, Jim; Rocchio, Rosemary A.

    2011-01-01

    Mobile use of the Internet is on target to surpass fixed use by 2014. Three-fourths of all college/university students have purchased or intend to purchase an Internet-enabled handheld device within the next year. The smartphone market is changing almost monthly. Attempting to manage even just one or a few "devices" is becoming a lost…

  18. Let's Talk About Water: Film Screenings as an Entrée to Water Science

    Science.gov (United States)

    Hooper, R. P.; Lilienfeld, L.; Arrigo, J.

    2011-12-01

    "Let's Talk about Water" is a film symposium designed to bring together experts and the public to talk about the complex water issues facing society. The format of the event is quite simple: a panel of experts and the audience view a water documentary (such as "FLOW", "Liquid Assets", or "Gasland") together and there is an extended moderated discussion period following the film between the panel and the audience. Properly handled, this simple format can be very effective. A film creates a context of subject and language for the discussion--it gets the audience and the panel on the same page. The moderators must actively manage the discussion, both challenging the panelists with follow up questions, asking questions to simplify the language the expert is using, and passing a question among panelists to bring out different points of view. The panelists are provided with the film in advance to view and, most importantly, meet the day before the event to discuss the film. This makes for a much more convivial discussion at the event. We have found that these discussions can easily be sustained for 90 to 120 minutes with active audience participation. This format has been applied at college campuses with a target audience of lower-level undergraduates. Student clubs are engaged to help with publicity before the event and to assist with registration and ushering during the event. Appropriate classes offer extra credit for student attendance to ensure a strong turnout. A Hollywood film ("Chinatown" in southern California, "A Civil Action" in Boston) is shown on campus during the week preceding the event to help advertise the event. The event itself is typically held on a Saturday with a morning screening of the film. The audience is provided with index cards and pencils to write down questions they have about the film. A lunch is provided during which the questions are organized and used to initiate different discussion themes. The discussion begins with points raised by

  19. Creating a Successful Academic Climate for Urban Students

    Science.gov (United States)

    Slaughter, Terri

    2009-01-01

    Teaching students in the inner city has been likened to hugging a porcupine--teachers nudge them toward success while getting pricked along the way. Many urban students perform below proficiency level and are difficult to manage. Their apathy toward completing class assignments, let alone homework, compounds the problem. As a whole, educators do…

  20. Student ID Cards: What You Should Know About Them

    Science.gov (United States)

    Hoffman, Jonathan; McGuire, Agnes C.

    1973-01-01

    Discusses the usefulness of photo ID cards for school security purposes, library control, student activities, and bus transportation control. Examines ways in which card costs can be reduced and the pros and cons of producing the cards at the school or of letting the work out. Problems involving card abuse and student rights are also considered.…

  1. US students have wrong view of teaching

    Science.gov (United States)

    Kruesi, Liz

    2017-04-01

    Students taking science, technology, engineering and mathematics (STEM) subjects in the US have a number of misconceptions about teaching that may be leading them to choose other careers, according to a study by the American Physical Society (APS).

  2. High-LET particle dosimetry in the ASTP-Biostack III: Zea mays experiment

    International Nuclear Information System (INIS)

    Peterson, D.D.; Benton, E.V.; Tran, M.; Yang, T.; Freeling, M.; Craise, L.; Tobias, C.A.

    1977-01-01

    High-LET particle hits in embryos of Zea mays (corn) seeds, flown as part of the ASTP-Biostack III, were determined via plastic nuclear track detectors. Based on etched particle-tracks measurements, 41 embryos were hit in seed layer 1 which contained 80 seeds, and 49 hits occurred in layer 2 which contained 79 seeds. The mean LET value and range of atomic numbers of recorded hits is, respectively, 210 +- 57 keV/μm and 9 approximately less than Z approximately less than 26. Detailed analysis of one particular seed showing marked growth anomalies revealed two hits in the central region of the embryo. These two hits had LET values in the region of 100 to 150 keV/μm, and Z less than approximately 20. (author)

  3. Cooperative interplay of let-7 mimic and HuR with MYC RNA.

    Science.gov (United States)

    Gunzburg, Menachem J; Sivakumaran, Andrew; Pendini, Nicole R; Yoon, Je-Hyun; Gorospe, Myriam; Wilce, Matthew C J; Wilce, Jacqueline A

    2015-01-01

    Both RNA-binding proteins (RBP) and miRNA play important roles in the regulation of mRNA expression, often acting together to regulate a target mRNA. In some cases the RBP and miRNA have been reported to act competitively, but in other instances they function cooperatively. Here, we investigated HuR function as an enhancer of let-7-mediated translational repression of c-Myc despite the separation of their binding sites. Using an in vitro system, we determined that a let-7 mimic, consisting of single-stranded (ss)DNA complementary to the let-7 binding site, enhanced the affinity of HuR for a 122-nt MYC RNA encompassing both binding sites. This finding supports the biophysical principle of cooperative binding by an RBP and miRNA purely through interactions at distal mRNA binding sites.

  4. The Othering in Kazuo Ishiguro’s Never Let Me Go

    Directory of Open Access Journals (Sweden)

    Matava Vichiensing

    2017-08-01

    Full Text Available In this article, I will investigate the concept of ‘othering’ originally as part of a post-colonial theory. This concept is interested in many academic areas, including a literary study. In Kazuo Ishiguro’s novel Never Let Me Go is about human clones raised for organs. The clones are excluded and discriminated to be ‘the other’ from the normal people. The manifestations of othering in Never Let Me Go can be presented in the forms of linguistic features, indoctrination, objectification, and assimilation. Although the othering phenomenon can be found in the reality, it can be appeared in literary texts as well. The findings show that the study of Kazuo Ishiguro’s Never Let Me Go helps us to understand and aware of how the negative consequences of the othering process affect undesirable treatments in the society as a whole.

  5. Depth-Dose and LET Distributions of Antiproton Beams in Various Target Materials

    DEFF Research Database (Denmark)

    Herrmann, Rochus; Olsen, Sune; Petersen, Jørgen B.B.

    the annihilation process. Materials We have investigated the impact of substituting the target material on  the depth-dose distribution of pristine and  spread out antiproton beams using the FLUKA Monte Carlo transport program. Classical ICRP targets are compared to water phantoms. In addition, track average...... unrestricted LET is calculated for all configurations. Finally, we investigate which concentrations of gadolinium and boron are needed in a water target in order to observe a significant change in the antiproton depth-dose distribution.  Results Results indicate, that there is no significant change...... in the depth-dose distribution and average LET when substituting the materials. Adding boron and gadolinium up to concentrations of 1 per 1000 atoms to a water phantom, did not change the depth-dose profile nor the average LET. Conclusions  According to our FLUKA calculations, antiproton neutron capture...

  6. Influence of chemical inhibitors on cell recovery after exposure to different LET radiation

    Energy Technology Data Exchange (ETDEWEB)

    Evstratova, Ekaterina S.; Petin, Vladislav G. [Medical Radiological Research Center, Obninsk (Russian Federation); Kim, Jin Kyu; KIm, Jin Hong [Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of)

    2016-12-15

    Chemical radiosensitizers are often used to increase cell radiosensitivity. It is known that the ability of chemical drugs to increase cell radiosensitivity is related with inhibition of cell recovery from damage induced by ionizing radiation. However, there are little comparative investigations of cell sensitivity modification after exposure to radiation with high linear energy transfer (LET). Therefore, we studied the anticancer drugs cisplatin and endoxan and their impact on the ability of yeast cells to recover after cell exposure to radiations with different LET. The ability of cell recovery from radiation damage was less effective after exposure to high-LET radiation, when cells were irradiated without drug, with the increase in cisplatin concentration resulting in the disappearance of this difference. The increase of cisplatin concentration results in progressive increase in the fraction of irreversible damage independently of radiation quality.

  7. Influence of chemical inhibitors on cell recovery after exposure to different LET radiation

    International Nuclear Information System (INIS)

    Evstratova, Ekaterina S.; Petin, Vladislav G.; Kim, Jin Kyu; KIm, Jin Hong

    2016-01-01

    Chemical radiosensitizers are often used to increase cell radiosensitivity. It is known that the ability of chemical drugs to increase cell radiosensitivity is related with inhibition of cell recovery from damage induced by ionizing radiation. However, there are little comparative investigations of cell sensitivity modification after exposure to radiation with high linear energy transfer (LET). Therefore, we studied the anticancer drugs cisplatin and endoxan and their impact on the ability of yeast cells to recover after cell exposure to radiations with different LET. The ability of cell recovery from radiation damage was less effective after exposure to high-LET radiation, when cells were irradiated without drug, with the increase in cisplatin concentration resulting in the disappearance of this difference. The increase of cisplatin concentration results in progressive increase in the fraction of irreversible damage independently of radiation quality.

  8. Your ParticleQuest, should you choose to accept it…

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    The CERN-developed ParticleQuest adventure game was the focus of a special hands-on session at last month’s Mozilla Festival in London. Attended by the best and the brightest of the coding community, the festival was an opportunity for the ParticleQuest developers to throw down the gaming gauntlet…   Photon and Gluon ParticleQuest sprites. Source: André-Pierre Olivier. A team of CERN students developed the ParticleQuest game during this year’s CERN Summer Student Webfest. What started as simple derivative software of BrowserQuest – one of the first entirely browser-based games developed by the Mozilla Foundation – soon revealed new opportunities to educate players about particle physics. By changing the graphics, introducing a Particle Zoo designed by web designer André-Pierre Olivier and enhancing the game engine, the summer students were convinced that ParticleQuest could help to teach particle physics in a much more ...

  9. How to choose methods for lake greenhouse gas flux measurements?

    Science.gov (United States)

    Bastviken, David

    2017-04-01

    Lake greenhouse gas (GHG) fluxes are increasingly recognized as important for lake ecosystems as well as for large scale carbon and GHG budgets. However, many of our flux estimates are uncertain and it can be discussed if the presently available data is representative for the systems studied or not. Data are also very limited for some important flux pathways. Hence, many ongoing efforts try to better constrain fluxes and understand flux regulation. A fundamental challenge towards improved knowledge and when starting new studies is what methods to choose. A variety of approaches to measure aquatic GHG exchange is used and data from different methods and methodological approaches have often been treated as equally valid to create large datasets for extrapolations and syntheses. However, data from different approaches may cover different flux pathways or spatio-temporal domains and are thus not always comparable. Method inter-comparisons and critical method evaluations addressing these issues are rare. Emerging efforts to organize systematic multi-lake monitoring networks for GHG fluxes leads to method choices that may set the foundation for decades of data generation and therefore require fundamental evaluation of different approaches. The method choices do not only regard the equipment but also for example consideration of overall measurement design and field approaches, relevant spatial and temporal resolution for different flux components, and accessory variables to measure. In addition, consideration of how to design monitoring approaches being affordable, suitable for widespread (global) use, and comparable across regions is needed. Inspired by discussions with Prof. Dr. Cristian Blodau during the EGU General Assembly 2016, this presentation aims to (1) illustrate fundamental pros and cons for a number of common methods, (2) show how common methodological approaches originally adapted for other environments can be improved for lake flux measurements, (3) suggest

  10. Cytotoxic and mutagenic effects of high let charged particles on human skin fibroblasts

    International Nuclear Information System (INIS)

    Tsuboi, Koji.; Park, M.S.; Chen, D.J.; Yang, T.C.

    1992-01-01

    Cytotoxic and mutagenic effects of high LET charged particles were quantitatively measured using primary cultures of human skin fibroblasts. The span of LETs selected were from 25 keV/μm(330 MeV/u) to 920 keV/μm (600 MeV/u). Mutations were scored at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus using 6-thioguanine (6-TG) for selection. Exposure to these high LET charged particles resulted in exponential survival curves whereas mutant induction was fitted by a linear model. The Relative Biological Effect (RBE) for cell-killing ranged from 3.73 to 1.25, while that for mutant induction ranged from 5.74 to 0.48. Maximum RBE values were obtained at the LET of 150 keV/μm. The inactivation cross-section (σ i ) and the action cross-section for mutant induction (σ m ) ranged from 2.2 to 92.0 μm 2 and 0.09 to 5.56 x 10 -3 μm 2 respectively, the maximum values were obtained by 56 Fe with an LET of 200 keV/μm. The mutagenicity (σ m /σ i ) ranged from 2.05 to 7.99 x 10 -5 with the maximum value at 150 keV/μm. Furthermore, the results of multiplex polymerase chain reaction (PCR) of some of the mutants induced by charged particles indicate that higher LET beams are more likely to cause larger deletions in the hprt locus. (author)

  11. Radiation-induced epigenetic alterations after low and high LET irradiations

    International Nuclear Information System (INIS)

    Aypar, Umut; Morgan, William F.; Baulch, Janet E.

    2011-01-01

    Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding radiation-induced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET X-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappa B (NFκB), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. We demonstrate that miRNA expression levels can be altered after X-ray irradiation and that these miRNA are involved in chromatin remodeling and DNA methylation. A higher incidence of epigenetic changes was observed after exposure to X-rays than Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This distinction is apparent at miRNA analyses at which only three miRNA involved in two major pathways were altered after high LET irradiations while six miRNA involved in five major pathways were altered after low LET irradiations. This study also shows that the irradiated cells acquire epigenetic changes suggesting that epigenetic aberrations may arise in the

  12. Expression of hsa Let-7a MicroRNA of Macrophages Infected by Leishmania Major

    Directory of Open Access Journals (Sweden)

    Nooshin Hashemi

    2016-10-01

    Full Text Available Leishmaniasis is a vector-born disease caused by species of the genus Leishmania and is transmitted from host to host through the bite of an infected sandfly. MicroRNAs (miRNAs are non-coding small RNAs with 22-nucleotide length. They are involved in some biological and cellular processes. We aimed to evaluate the expression of let-7a in human macrophages miRNA when are infected by Leishmania major. We also evaluated the impact of Leishmania major infection on the expression of let-7a at two different times, 24 and 48 hours, after infection. Blood samples were collected from ten healthy volunteers with no history of leishmaniasis. Development of macrophages from peripheral monocytes and infection with stationary phase of Leishmania major promastigotes were done through serial cultures under 5% CO2 environment and 37C. To measure the expression levels of let-7a real-time PCR was performed with specific related primers using the SYBR® Green master mix Kit™. The real-time PCR showed let-7a was expressed in cells infected with parasites after 24 and 48h post-infection. Comparison of let-7a miRNA expression after 24 and 48 h revealed that let-7a miRNAs were down-regulated at 48 h post-infection more than 24h after infection. The results of this study suggest that according to the main function of miRNA in repression of mRNA translation it could be possible to manipulate host cells in order to alter miRNA levels and regulate macrophage functions after establishment of intracellular parasites such as Leishmania.

  13. CD95 is part of a let-7/p53/miR-34 regulatory network.

    Directory of Open Access Journals (Sweden)

    Annika Hau

    Full Text Available The death receptor CD95 (APO-1/Fas mediates apoptosis induction upon ligation by its cognate ligand CD95L. Two types of CD95 signaling pathways have been identified, which are characterized by the absence (Type I or presence (Type II of mitochondrial involvement. Micro(miRNAs are small noncoding RNAs that negatively regulate gene expression. They are important regulators of differentiation processes and are found frequently deregulated in many human cancers. We recently showed that Type I cells express less of the differentiation marker miRNA let-7 and, hence, likely represent more advanced tumor cells than the let-7 high expressing Type II cells. We have now identified miR-34a as a selective marker for cells that are sensitive to CD95-mediated apoptosis. Both CD95 and miR-34a are p53 target genes, and consequently, both the sensitivity of cancer cells to CD95-mediated apoptosis and the ability to respond to p53 mediated DNA genotoxic stress are linked. Interestingly, while miR-34a was found to positively correlate with the ability of cells to respond to genotoxic stress, let-7 was negatively correlated. The expression level of CD95 inversely correlated with the expression of let-7 suggesting regulation of let-7 expression by CD95. To test a link between p53 and miR-34a, we altered the expression of CD95. This affected the ability of cells to activate p53 and to regulate miR-34a. Our data point to a novel regulatory network comprising p53, CD95, let-7, and miR-34a that affects cancer cell survival, differentiation, and sensitivity to apoptotic signals. The possible relevance of this regulatory network for cancer stem cells is discussed.

  14. Radiation-induced epigenetic alterations after low and high LET irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Aypar, Umut, E-mail: uaypa001@umaryland.edu [Department of Radiation Oncology, Radiation Oncology Research Laboratory, University of Maryland School of Medicine, Baltimore, MD 21201 (United States); Morgan, William F. [Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352 (United States); Baulch, Janet E. [Department of Radiation Oncology, Radiation Oncology Research Laboratory, University of Maryland School of Medicine, Baltimore, MD 21201 (United States)

    2011-02-10

    Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding radiation-induced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET X-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappa B (NF{kappa}B), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. We demonstrate that miRNA expression levels can be altered after X-ray irradiation and that these miRNA are involved in chromatin remodeling and DNA methylation. A higher incidence of epigenetic changes was observed after exposure to X-rays than Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This distinction is apparent at miRNA analyses at which only three miRNA involved in two major pathways were altered after high LET irradiations while six miRNA involved in five major pathways were altered after low LET irradiations. This study also shows that the irradiated cells acquire epigenetic changes suggesting that epigenetic aberrations may arise

  15. Radiation-Induced Epigenetic Alterations after Low and High LET Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Aypar, Umut; Morgan, William F.; Baulch, Janet E.

    2011-02-01

    Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding the delayed, non-targeted effects of radiation including radiationinduced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET x-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappa B (NFκB), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. MiRNA shown to be altered in expression level after x-ray irradiation are involved in chromatin remodeling and DNA methylation. Different and higher incidence of epigenetic changes were observed after exposure to low LET x-rays than high LET Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This study also shows that the irradiated cells acquire epigenetic changes even though they are chromosomally stable suggesting that epigenetic aberrations may arise in the cell without initiating RIGI.

  16. Student support infrastructure

    DEFF Research Database (Denmark)

    Nøhr, Christian

    2004-01-01

    The development and diffusion of distance learning programmes has made it possible for students to choose their preferred location to study and consequently, they are expected to be able to use new technologies in order to gain necessary support in a wide range of ares. When universities implement...

  17. Choose and Tell Cards: A 4-H Cloverbud Resource for Promoting Public Speaking and Life Skills

    Science.gov (United States)

    Stechschulte, Jill; Scheer, Scott D.

    2017-01-01

    Choose and Tell is a curriculum for 4-H Cloverbud members that introduces them to public speaking and life skill enhancement (communication and social interaction). Choose and Tell consists of activity cards analogous to a deck of cards. Activity card titles include Wash and Comb Your Hair, Plant a Seed, and Floss Your Teeth. The activities are…

  18. Acting on One's Attitudes: The Role of a History of Choosing Situations.

    Science.gov (United States)

    DeBono, Kenneth G.; Snyder, Mark

    1995-01-01

    Three investigations examined the contributions of a history of choosing attitudinally relevant situations to attitude-behavior relations. Results point to an interrelated set of mechanisms, such as behavior, by which situational choice is linked to attitude-behavior relations. By choosing attitudinally relevant situations, individuals increase…

  19. Let Them Have Their Cell Phone (And Let Them Read to It Too): Technology, Writing Instruction and Textual Obsolescence

    Science.gov (United States)

    Shahar, Jed

    2012-01-01

    Cell phone ubiquity enables students to record and share audio file versions of their essays for proofreading purposes. Adopting this practice in community college developmental writing classes leads to an investigation of both writing as a technology and the influence of modern technology on composition and composition pedagogy.

  20. Induction of λ prophage in lysogenic E.Coli exposed to ionizing radiation of different let

    International Nuclear Information System (INIS)

    Bonev, M.; Kozubek, S.; Krasavin, E.A.; Cherevatenko, A.P.

    1988-01-01

    Induction of λ prophage in lysogenic E. coli cells exposed to ionizing radiation of different LET was studied as a function of dose I(D). Activities of pleiotropic RecA protein were shown to contribute to the shape of the I(D) curve. The experimental data were fitted by the function I(D)=αD(1-exp(-D 0 -1 xD))exp(-βD). Inducibility α increased with increasing LET which was related to the increased incidence of DNA lesions being a SOS - system call

  1. Cooperative interplay of let-7 mimic and HuR with MYC RNA

    OpenAIRE

    Gunzburg, Menachem J; Sivakumaran, Andrew; Pendini, Nicole R; Yoon, Je-Hyun; Gorospe, Myriam; Wilce, Matthew Cj; Wilce, Jacqueline A

    2015-01-01

    Both RNA-binding proteins (RBP) and miRNA play important roles in the regulation of mRNA expression, often acting together to regulate a target mRNA. In some cases the RBP and miRNA have been reported to act competitively, but in other instances they function cooperatively. Here, we investigated HuR function as an enhancer of let-7-mediated translational repression of c-Myc despite the separation of their binding sites. Using an in vitro system, we determined that a let-7 mimic, consisting of...

  2. TH-CD-209-06: LET-Based Adjustment of IMPT Plans Using Prioritized Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Unkelbach, J; Giantsoudi, D; Paganetti, H [Massachusetts General Hospital, Boston, MA (United States); Botas, P [Massachusetts General Hospital, Boston, MA (United States); Heidelberg University, Heidelberg, DE (Germany); Qin, N; Jia, X [The University of Texas Southwestern Medical Ctr, Dallas, TX (United States)

    2016-06-15

    Purpose: In-vitro experiments suggest an increase in proton relative biological effectiveness (RBE) towards the end of range. However, proton treatment planning and dose reporting for clinical outcome assessment has been based on physical dose and constant RBE. Therefore, treatment planning for intensity-modulated proton therapy (IMPT) is unlikely to transition radically to pure RBE-based planning. We suggest a hybrid approach where treatment plans are initially created based on physical dose constraints and prescriptions, and are subsequently altered to avoid high linear energy transfer (LET) in critical structures while limiting the degradation of the physical dose distribution. Methods: To allow fast optimization based on dose and LET we extended a GPU-based Monte-Carlo code towards providing dose-averaged LET in addition to dose for all pencil beams. After optimizing an initial IMPT plan based on physical dose, a prioritized optimization scheme is used to modify the LET distribution while constraining the physical dose objectives to values close to the initial plan. The LET optimization step is performed based on objective functions evaluated for the product of physical dose and LET (LETxD). To first approximation, LETxD represents a measure of the additional biological dose that is caused by high LET. Regarding optimization techniques, LETxD has the advantage of being a linear function of the pencil beam intensities. Results: The method is applicable to treatments where serial critical structures with maximum dose constraint are located in or near the target. We studied intra-cranial tumors (high-grade meningiomas, base-of-skull chordomas) where the target (CTV) overlaps with the brainstem and optic structures. Often, high LETxD in critical structures can be avoided while minimally compromising physical dose planning objectives. Conclusion: LET-based re-optimization of IMPT plans represents a pragmatic approach to bridge the gap between purely physical dose

  3. Linear energy transfer (LET) effects in the radiation-induced inactivation of papain

    International Nuclear Information System (INIS)

    Bisby, R.H.; Cundall, R.B.; Sims, H.E.; Burns, W.G.

    1977-01-01

    The inactivation of dilute aqueous solutions of papain by radiations of varying linear energy transfer has been studied in N 2 , N 2 0 and O 2 -saturated solutions. The results obtained with low LET radiation are very similar to those previously reported by Lin et al (Radiation Res.;62:438(1975)). The additional data obtained at higher LET, when radical product yields are reduced and the yield of hydrogen peroxide is increased, show that the hydrogen atom is more important in the inactivation of papain than previously considered. (author)

  4. Let us look at the population issue unflinchingly.

    Science.gov (United States)

    Shahani, L R

    1992-09-01

    This abridged statement of Senator Leticia Ramos Shahani argues for a coherent and comprehensive policy on population that does not aim to control numbers but intends to provide people with choices. Over the past three decades, the population of the Philippines has tripled, to 60.7 million. Distribution is unequal. The nation's capital region, which is 0.2% of the country's land area, contains 13% of the total population: there 12,498 people occupy a square kilometer. The primary sewage network in Metro Manila was built in 1904 to accommodate 500,000 people. Even the planned expansion will accommodate only 20% of Metro Manila's present population. There are regions of the Philippines where children have no access to schools, despite a law providing free and compulsory elementary education. Some 912,000 people in rural areas are without employment. Their response is often to move to the cities or ecologically sensitive areas. The Philippines has one of the highest rates of maternal mortality in the world. Infant mortality has remained at about 61 deaths per 1000 live births for the past decade. Family planning can be an effective weapon against these statistics; studies done in the Philippines indicate that infant and child mortality rates would drop by 25% each if pregnancy were avoided by women younger than 20 or older than 35, or with 4 or more children, or who are less than 15 months postpartum. A majority of respondents in a 1991 nationwide survey stated that they did not feel strongly restricted from using family planning, whether by their religion, education, or doctors. Any population policy must have an ethical and moral dimension, in keeping with freedom, human dignity, personal values, and culture. Couples have the right to choose any means, natural or artificial, they find appropriate to plan their families. Legislative efforts of the 1980s have not fulfilled their tasks. The population policy of the Philippines should: 1) deal with with underlying

  5. Secondary School Students' Misconceptions about Photosynthesis and Plant Respiration: Preliminary Results

    Science.gov (United States)

    Svandova, Katerina

    2014-01-01

    The study investigated the common misconceptions of lower secondary school students regarding the concepts of photosynthesis and plant respiration. These are abstract concepts which are difficult to comprehend for adults let alone for lower secondary school students. Research of the students misconceptions are conducted worldwide. The researches…

  6. Choosing to Compete: How Different are Girls and Boys?

    OpenAIRE

    Alison L. Booth; Patrick Nolen

    2009-01-01

    Using a controlled experiment, we examine the role of nurture in explaining the stylized fact that women shy away from competition. Our subjects (students just under 15 years of age) attend publicly-funded single-sex and coeducational schools. We find robust differences between the competitive choices of girls from single-sex and coed schools. Moreover, girls from single-sex schools behave more like boys even when randomly assigned to mixed-sex experimental groups. Thus it is untrue that the ...

  7. Which Middle-Level School Should We Choose? Four Common Traits of Schools Demonstrating Student Growth

    Science.gov (United States)

    Pfeiffer, Linda E.

    2015-01-01

    Few things strike fear in the hearts of parents like sending their child off to middle school. Parents of gifted learners fear for their child's safety--both emotional and physical--and their academic well-being. Having survived this transition, it occurred to the author that this experience would make an interesting research project and,…

  8. STUDY OF THE LEVELS OF DEVELOPMENT OF MOTIVATION HIGH SCHOOL STUDENTS TO CHOOSE PROFESSION

    Directory of Open Access Journals (Sweden)

    Ольга Анатольевна Любягина

    2014-06-01

    Full Text Available В настоящее время проблема формирования мотивационной готовности к профессиональному самоопределению старшеклассников становится все актуальней, поскольку в современном обществе становится востребованной личность со способностями к самопознанию, самосовершенствованию, саморазвитию, которые закладываются в старшем школьном возрасте. Цель работы - исследование развития мотивационной готовности старшеклассников к профессиональному самоопределению на основе внедрения модели системы подготовки старшеклассников к профессиональному самоопределению в учебно-воспитательный процесс. Разработаны критерии оценки мотивационной готовности старшеклассников к профессиональному самоопределению. В качестве материала эксперимента использовался разработанный системный комплекс развития мотивационной готовности старшеклассников к профессиональному самоопределению. В результате эксперимента было получено значительное повышение высокого уровня мотивационной готовности старшеклассников в экспериментальной группе, что свидетельствует о том, что применение модели подготовки старшеклассников к профессиональному самоопределению у школьников формирует мотивационную готовность к выбору будущей профессии. Результаты исследования могут быть использованы педагогами лицеев, гимназий, учреждений дополнительного образования при работе со школьниками.DOI: http://dx.doi.org/10.12731/2218-7405-2013-12-9 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

  9. Let-7b Regulates Myoblast Proliferation by Inhibiting IGF2BP3 Expression in Dwarf and Normal Chicken

    Science.gov (United States)

    Lin, Shumao; Luo, Wen; Ye, Yaqiong; Bekele, Endashaw J.; Nie, Qinghua; Li, Yugu; Zhang, Xiquan

    2017-01-01

    The sex-linked dwarf chicken is caused by the mutation of growth hormone receptor (GHR) gene and characterized by shorter shanks, lower body weight, smaller muscle fiber diameter and fewer muscle fiber number. However, the precise regulatory pathways that lead to the inhibition of skeletal muscle growth in dwarf chickens still remain unclear. Here we found a let-7b mediated pathway might play important role in the regulation of dwarf chicken skeletal muscle growth. Let-7b has higher expression in the skeletal muscle of dwarf chicken than in normal chicken, and the expression of insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), which is a translational activator of IGF2, showed opposite expression trend to let-7b. In vitro cellular assays validated that let-7b directly inhibits IGF2BP3 expression through binding to its 3′UTR region, and the protein level but not mRNA level of IGF2 would be reduced in let-7b overexpressed chicken myoblast. Let-7b can inhibit cell proliferation and induce cell cycle arrest in chicken myoblast through let-7b-IGF2BP3-IGF2 signaling pathway. Additionally, let-7b can also regulate skeletal muscle growth through let-7b-GHR-GHR downstream genes pathway, but this pathway is non-existent in dwarf chicken because of the deletion mutation of GHR 3′UTR. Notably, as the loss binding site of GHR for let-7b, let-7b has enhanced its binding and inhibition on IGF2BP3 in dwarf myoblast, suggesting that the miRNA can balance its inhibiting effect through dynamic regulate its binding to target genes. Collectively, these results not only indicate that let-7b can inhibit skeletal muscle growth through let-7b-IGF2BP3-IGF2 signaling pathway, but also show that let-7b regulates myoblast proliferation by inhibiting IGF2BP3 expression in dwarf and normal chickens. PMID:28736533

  10. EFFORTS TO INCREASE THE ABILITY TO CHOOSE A SCHOOL GROUP COUNSELING SERVICES THROUGH ADVANCED CLASS IX SMP NEGERI 2 METRO STATE IN 2013

    Directory of Open Access Journals (Sweden)

    Rohima Rohima

    2016-06-01

    Full Text Available SMP Negeri 2 Metro In reality, there are many confused students choose a major program of advanced studies, especially for junior high school students. It is necessary to learn / coaching to the students to be able to choose the school accordingly. Researchers conduct action research through the Guidance Counseling Group in Class IX student of SMP Negeri 2 Metro. The experiment was conducted using two cycles. Recapitulation of data Selecting a program majoring in the process of learning / coaching from the first cycle to the second cycle, there is an increase of 57.06% to 86.35%. The results of the data summary portfolio also increased from 33.32% to 83.33%, and the recapitulation of learning outcomes of students who otherwise Completed Pass also risen from 54.54% increase to 96.96%. Thus concluded indicator of success is to reach the target / as are 95% or more. Keywords: guidance group, select schools, smp negeri 2 metro

  11. Contest ``LET your School GO Into - Space Baptism 2007

    Science.gov (United States)

    Sánchez, G.

    2009-05-01

    The contest ``Space Baptism 2007'' was organized with the cooperation of the Mirador de la Ciencia, a science museum associated with the local zoo in Barquisimeto, Venezuela, and in collaboration with the Asociación Larense de Astronomía, a local astronomy amateur group. This contest was aimed at students of primary schools and had as a final award the chance to give a proper name to an asteroid. The ultimate goal of the contest was to promote basic and space sciences to children and the young through activities that involved the creation of stories related to astronomy, enforcing creativity and originality, and encouraging group work and solidarity. As a result, the asteroid (12758) 1993 SM3 will be known from now on as (12758) Kabudarí. The success of this initiative is demonstrated by stories about the contest that appeared in several publications in local newspapers and magazines about the school and the students who won the contest. We are currently developing plans for repetitions of the contest to name two more asteroids.

  12. Relational Leading – Appreciating Letting Go, and Not Knowing Where You Are Going

    DEFF Research Database (Denmark)

    Larsen, Mette Vinther

    2016-01-01

    In this article we meet Steven,the manager of a Danish regional regional medical supply organization. With him, we explore how – even for leaders – it can feel liberating to let go of existing knowledge and understanding and embark on a journey with others with the certainty that no one knows where...

  13. Measurements of LET Spectra of the JINR Phasotron Radiotherapy Proton Beam

    Czech Academy of Sciences Publication Activity Database

    Kubančák, Ján; Molokanov, A. G.

    2013-01-01

    Roč. 2013, č. 6 (2013), s. 90-92 ISSN 1562-6016 R&D Projects: GA MŠk LA08002 Institutional support: RVO:61389005 Keywords : LET spectra * proton beam Subject RIV: BO - Biophysics Impact factor: 0.102, year: 2013 http:// vant .kipt.kharkov.ua/ARTICLE/ VANT _2013_6/article_2013_6_90.pdf

  14. Synchronizing Education to Adolescent Biology: "Let Teens Sleep, Start School Later"

    Science.gov (United States)

    Kelley, Paul; Lockley, Steven W.; Foster, Russell G.; Kelley, Jonathan

    2015-01-01

    Arne Duncan, US Secretary of State for Education, tweeted in 2013: "let teens sleep, start school later". This paper examines early starts and their negative consequences in the light of key research in the last 30 years in sleep medicine and circadian neuroscience. An overview of the circadian timing system in adolescence leading to…

  15. Generating Code with Polymorphic let: A Ballad of Value Restriction, Copying and Sharing

    Directory of Open Access Journals (Sweden)

    Oleg Kiselyov

    2017-02-01

    Full Text Available Getting polymorphism and effects such as mutation to live together in the same language is a tale worth telling, under the recurring refrain of copying vs. sharing. We add new stanzas to the tale, about the ordeal to generate code with polymorphism and effects, and be sure it type-checks. Generating well-typed-by-construction polymorphic let-expressions is impossible in the Hindley-Milner type system: even the author believed that. The polymorphic-let generator turns out to exist. We present its derivation and the application for the lightweight implementation of quotation via a novel and unexpectedly simple source-to-source transformation to code-generating combinators. However, generating let-expressions with polymorphic functions demands more than even the relaxed value restriction can deliver. We need a new deal for let-polymorphism in ML. We conjecture the weaker restriction and implement it in a practically-useful code-generation library. Its formal justification is formulated as the research program.

  16. 'The Gentle Art of Letting the Other Fellow Have Your Own Way ...

    African Journals Online (AJOL)

    'The Gentle Art of Letting the Other Fellow Have Your Own Way': Viewpoints on a Media Narrative used to Promote the Proposed N2 Toll Road. ... We highlight the importance of developing 'media literacy' – reading skills which enable the critical deconstruction of media texts. We explore, more specifically, the public ...

  17. Simulations of chopper jitter at the LET neutron spectrometer at the ISIS TS2

    DEFF Research Database (Denmark)

    Klenø, Kaspar Hewitt; Lefmann, Kim; Willendrup, Peter Kjær

    2014-01-01

    The effect of uncertainty in chopper phasing (jitter) has been investigated for the high-resolution time-of-flight spectrometer LET at the ISIS second target station. The investigation is carried out using virtual experiments, with the neutron simulation package McStas, where the chopper jitter i...

  18. Let’s Stop HIV Together: Jamar Rogers

    Centers for Disease Control (CDC) Podcasts

    2012-07-16

    In this podcast, singer Jamar Rogers shares his personal story in the Let's Stop HIV Together Campaign.  Created: 7/16/2012 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 7/16/2012.

  19. Let's say goodbye : The moralising practices of gap year organisations in the Netherlands

    NARCIS (Netherlands)

    Hermann, I. (Inge)

    2013-01-01

    http://cts.som.surrey.ac.uk/publication/lets-say-goodbye-the-moralising-practices-of-gap-year-organisations-in-the-netherlands/wppa_open/   Responding to the growing appeal of the gap year amongst young people, the higher education sector, governmental institutions and, perhaps foremost, the

  20. Water radiolysis in extreme conditions of temperature and LET. Scavenging of HO. by Br- ions

    International Nuclear Information System (INIS)

    Saffre, Dimitri

    2011-01-01

    The purpose of this thesis is to contribute to the understanding of the oxidation mechanism of Br - in which the HO . radical is involved. The HO . radiolytic yield is strongly connected with the oxidation yield of Br - , and therefore we have studied the influence of different physical and chemical parameters on this global yield: temperature, LET, dose rate, pH, saturation gas. The solutions have been irradiated with 4 types of ionizing rays: X-rays (from 13 to 18 keV), electrons (from 7 to 10 MeV), C 6+ -ions beam of 975 MeV and He 2+ -ions beam of 70 MeV. The development of an optical autoclave with solution flow, compatible with high LET ionizing rays has allowed us conduct the first experiments at constant high LET and high temperature. This cell has turned out to be compatible with the picosecond pump-probe experiments performed with the ELYSE accelerator. The HO . scavenging yield has been, therefore, estimated at both high LET and high temperature. A better understanding of the Br - oxidation mechanism has been achieved, in acid medium, in particular, by comparing the kinetics results with Monte Carlo Simulations for time scales inferior to the microsecond and with Chemsimul for the stable products (Br 2 .- and Br 3 - formations). (author) [fr

  1. "Cloning Words": Euphemism, Neologism and Dysphemism as Literary Devices in Kazuo Ishiguro's "Never Let Me Go"

    Science.gov (United States)

    Pandey, Anjali

    2011-01-01

    This essay examines the theme and trope of "copies" in Kazuo Ishiguro's novel "Never Let Me Go." Whatever one's final reading of the novel, the theme and thread of copy, copies, copying and copied is never far off. In a semantic sense then, the act of "copying", both as a verb and the indexing of "copies" as…

  2. Effects of estrogen and gender on cataractogenesis induced by high-LET radiation

    International Nuclear Information System (INIS)

    Henderson, M.A.; Rusek, A.; Valluri, S.; Garrett, J.; Lopez, J.; Caperell-Grant, A.; Mendonca, M.; Bigsby, R.; Dynlacht, J.

    2010-01-01

    Planning for long-duration manned lunar and interplanetary missions requires an understanding of radiation-induced cataractogenesis. Previously, it was demonstrated that low-linear energy transfer (LET) irradiation with 10 Gy of 60 Co γ rays resulted in an increased incidence of cataracts in male rats compared to female rats. This gender difference was not due to differences in estrogen, since male rats treated with the major secreted estrogen 17-β-estradiol (E2) showed an identical increase compared to untreated males. We now compare the incidence and rate of progression of cataracts induced by high-LET radiation in male and female Sprague-Dawley rats. Rats received a single dose of 1 Gy of 600 MeV 56 Fe ions. Lens opacification was measured at 2-4 week intervals with a slit lamp. The incidence and rate of progression of radiation-induced cataracts was significantly increased in the animals in which estrogen was available from endogenous or exogenous sources. Male rats with E2 capsules implanted had significantly higher rates of progression compared to male rats with empty capsules implanted (P = 0.025) but not compared to the intact female rats. These results contrast with data obtained after low-LET irradiation and suggest the possibility that the different types of damage caused by high- and low-LET radiation may be influenced differentially by steroid sex hormones.

  3. Cosmic ray LET spectra and doses on board Cosmos-2044 biosatellite

    International Nuclear Information System (INIS)

    Dudkin, V.E.; Kovalev, E.E.; Potapov, Yu.V.

    1992-01-01

    Results of the experiments on board Cosmos-2044 (Biosatellite 9) are presented. Various nuclear track detectors (NTD) (dielectric, AgCl-based, nuclear emulsions) were used to obtain the LET spectra inside and outside the satellite. The spectra from the different NTDs have proved to be in general agreement. The results of LET spectra calculations using two different models are also presented. The resultant LET distributions are used to calculate the absorbed and equivalent doses and the orbit-averaged quality factors (QF) of the cosmic rays (CR). Absorbed dose rates inside (∼ 20 g cm -2 shielding) and outside (1 g cm -2 ) the spacecraft, omitting electrons, were found to be 4.8 and 8.6 mrad d -1 , respectively, while the corresponding equivalent doses were 8.8 and 19.7 mrem d -1 . The effects of the flight parameters on the total fluence of, and on the dose from, the CR particles are analyzed. Integral dose distributions of the detected particles are also determined. The LET values which separate absorbed and equivalent doses into 50% intervals are estimated. The CR-39 dielectric NTD is shown to detect 20-30% of the absorbed dose and 60-70% of the equivalent dose in the Cosmos-2044 orbit. The influence of solar activity phase on the magnitude of the CR flux is discussed. (author)

  4. The induction of somatic mutations by high-LET radiation observed using the Drosophila assay system

    International Nuclear Information System (INIS)

    Yoshikawa, Isao; Takatsuji, Toshihiro; Nagano, Masaaki; Hoshi, Masaharu; Takada, Jun; Endo, Satoru

    1999-01-01

    To evaluate the mutagenic potential of high-LET radiation, an analysis was made on the production of somatic mutations by 252 Cf fission neutron s and heavy particle ions accelerated by a synchrotron. A Drosophila strain that allows simultaneous detection of two types of mutations in an identical fly was constructed. One was a wing-hair mutation and the other was an eye-color mosaic spot mutation. Measurements were made using a combined assay system of both mutation assays. Larvae were exposed to radiation at the age of post-ovipositional day-3. The efficiency of 252 Cf neutrons for inducing wing-hair mosaic spots was very high, the relative biological effectiveness (RBE) = 8.5, but the efficiency for eye-color mosaic spot was nearly equal (RBE = 1.2) to that of 137 Cs γ-rays. The RBE of carbon ions for inducing wing-hair mosaic spots increased as an increase in LET values. The RBE for the induction of eye-color mutants did not change with LET. These relationships suggest that more complex types of DNA damages such as non-rejoinable strand break or clustered double strand break, which increase with LET may be responsible for the induction of wing-hair mutation, while simpler forms of molecular damage may induce a reversion in the white-ivory allele. (M.N.)

  5. "Let's Count": Evaluation of a Pilot Early Mathematics Program in Low Socioeconomic Locations in Australia

    Science.gov (United States)

    Perry, Bob; Gervasoni, Ann; Dockett, Sue

    2012-01-01

    The "Let's Count" pilot early mathematics program was implemented in five early childhood educational contexts across Australia during 2011. The program used specifically formulated materials and workshops to enlist the assistance of early childhood educators to work with parents and other family members of children in their settings to…

  6. Eesti talendid raadiokonkurssidel "New Talent" ja "Let the Peoples Sing" / Karin Kopra

    Index Scriptorium Estoniae

    Kopra, Karin

    2005-01-01

    Bratislavas toimunud noorte interpreetide võistlusest "New Talent", kus osales ka pianist Mihkel Poll ning rahvusvahelisest amatöörkooride konkursist "Let the Peoples Sing" Kölnis, kus osalesid Eesti Televisiooni tütarlastekoor ja Tallinna Muusikakeskkooli lastekoor

  7. Choosing a Color model in CBIR-Systems

    Directory of Open Access Journals (Sweden)

    Andrej Cimerman

    2014-09-01

    Full Text Available AbstractIn the paper we study how the choice of color space affects the user-friendliness of the graphical user interface of CBIR. The pilot study was carried out on 46 students of the Department of Library and Information Science and Book Studies at the Faculty of Arts at the University of Ljubljana. The study showed that user interfaces based on HSV color space are simple to use even for users who do not possess the theoretical knowledge about colors and do not understand HSV color space, while even reasonably good understanding of RG B color space does not guarantee frustration-free user experience when using RG B user interface. User interfaces offering color choice just by clicking were better received than user interfaces that make use of color sliders. This article provides guidance for designing an interface for selecting color in CBIR systems.

  8. Let-7i-Induced Atg4B Suppression Is Essential for Autophagy of Placental Trophoblast in Preeclampsia.

    Science.gov (United States)

    Xu, Yinyan; Huang, Xinyan; Xie, Juan; Chen, Yanni; Fu, Jing; Wang, Li

    2017-09-01

    Autophagy, identified as type II programmed cell death, has already been known to be involved in the pathophysiology of preeclampsia (PE), which is a gestational disease with high morbidity. The present study aims to investigate the functional role of let-7i, a miRNA, in trophoblastic autophagy. Placental tissue used in this study was collected from patients with severe preeclampsia (SPE) or normal pregnant women. A decreased level of let-7i was found in placenta of SPE. In addition, autophagic vacuoles were observed in SPE and the expression of microtubule associated protein 1 light chain 3 (LC3) II/I was elevated. In vitro, let-7i mimics suppressed the autophagic activities in human HTR-8/SVneo trophoblast cell line (HTR-8) and human placental choriocarcinoma cell line JEG-3, whereas let-7i inhibitor enhanced the activities. As a potential target of let-7i, autophagy-related 4B cysteine peptidase (Atg4B) had an increased expression level in SPE. As expected, the increased expression of Atg4B was negatively regulated by let-7i using dual luciferase reporter assay. Furthermore, these trophoblast-like cells transfected with the let-7i mimic or inhibitors resulted in a significant change of Atg4B in both mRNA and protein level. More importantly, Atg4B overexpression could partly reverse let-7i mimic-reduced LC3II/I levels; whereas Atg4B silencing partly attenuated let-7i inhibitor-induced the level of LC3II/I expression. Taken together, these findings suggest that let-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of PE. J. Cell. Physiol. 232: 2581-2589, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  9. High LET Radiation Amplifies Centrosome Overduplication Through a Pathway of γ-Tubulin Monoubiquitination

    Energy Technology Data Exchange (ETDEWEB)

    Shimada, Mikio [Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto (Japan); Hirayama, Ryoichi [Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Komatsu, Kenshi, E-mail: komatsu@house.rbc.kyoto-u.ac.jp [Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto (Japan)

    2013-06-01

    Purpose: Radiation induces centrosome overduplication, leading to mitotic catastrophe and tumorigenesis. Because mitotic catastrophe is one of the major tumor cell killing factors in high linear energy transfer (LET) radiation therapy and long-term survivors from such treatment have a potential risk of secondary tumors, we investigated LET dependence of radiation-induced centrosome overduplication and the underlying mechanism. Methods and Materials: Carbon and iron ion beams (13-200 keV/μm) and γ-rays (0.5 keV/μm) were used as radiation sources. To count centrosomes after IR exposure, human U2OS and mouse NIH3T3 cells were immunostained with antibodies of γ-tubulin and centrin 2. Similarly, Nbs1-, Brca1-, Ku70-, and DNA-PKcs-deficient mouse cells and their counterpart wild-type cells were used for measurement of centrosome overduplication. Results: The number of excess centrosome-containing cells at interphase and the resulting multipolar spindle at mitosis were amplified with increased LET, reaching a maximum level of 100 keV/μm, followed by sharp decrease in frequency. Interestingly, Ku70 and DNA-PKcs deficiencies marginally affected the induction of centrosome overduplication, whereas the cell killings were significantly enhanced. This was in contrast to observation that high LET radiation significantly enhanced frequencies of centrosome overduplication in Nbs1- and Brca1-deficient cells. Because NBS1/BRCA1 is implicated in monoubiquitination of γ-tubulin, we subsequently tested whether it is affected by high LET radiation. As a result, monoubiquitination of γ-tubulin was abolished in 48 to 72 hours after exposure to high LET radiation, although γ-ray exposure slightly decreased it 48 hours postirradiation and was restored to a normal level at 72 hours. Conclusions: High LET radiation significantly reduces NBS1/BRCA1-mediated monoubiquitination of γ-tubulin and amplifies centrosome overduplication with a peak at 100 keV/μm. In contrast, Ku70 and DNA

  10. pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans.

    Science.gov (United States)

    Martin, Emmanuel; Harel, Sharon; Nkengfac, Bernard; Hamiche, Karim; Neault, Mathieu; Jenna, Sarah

    2014-01-01

    Cell shape changes are crucial for metazoan development. During Caenorhabditis elegans embryogenesis, epidermal cell shape changes transform ovoid embryos into vermiform larvae. This process is divided into two phases: early and late elongation. Early elongation involves the contraction of filamentous actin bundles by phosphorylated non-muscle myosin in a subset of epidermal (hypodermal) cells. The genes controlling early elongation are associated with two parallel pathways. The first one involves the rho-1/RHOA-specific effector let-502/Rho-kinase and mel-11/myosin phosphatase regulatory subunit. The second pathway involves the CDC42/RAC-specific effector pak-1. Late elongation is driven by mechanotransduction in ventral and dorsal hypodermal cells in response to body-wall muscle contractions, and involves the CDC42/RAC-specific Guanine-nucleotide Exchange Factor (GEF) pix-1, the GTPase ced-10/RAC and pak-1. In this study, pix-1 is shown to control early elongation in parallel with let-502/mel-11, as previously shown for pak-1. We show that pix-1, pak-1 and let-502 control the rate of elongation, and the antero-posterior morphology of the embryos. In particular, pix-1 and pak-1 are shown to control head, but not tail width, while let-502 controls both head and tail width. This suggests that let-502 function is required throughout the antero-posterior axis of the embryo during early elongation, while pix-1/pak-1 function may be mostly required in the anterior part of the embryo. Supporting this hypothesis we show that low pix-1 expression level in the dorsal-posterior hypodermal cells is required to ensure high elongation rate during early elongation.

  11. The induction of somatic mutations by high-LET radiations using the drosophila assay system

    International Nuclear Information System (INIS)

    Yoshikawa, Isao; Takatsuji, Toshihiro

    2004-01-01

    Two types of somatic mutation in Drosophila melanogaster were examined to evaluate the relative biological effectiveness (RBE) of 252 Cf neutrons and heavy ions (carbon ions and neon ions) accelerated with a synchrotron for inducing mutations as a function of linear energy transfer (LET). One is the loss of heterozygosity for wing-hair mutations and the other the reversion of the mutant white-ivory. The measurements were made using a combined mutation assay system; so that induced mutant wing-hair clones as well as revertant eye-color clones could be detected simultaneously in the same fly. Larvae were irradiated at the age of 3 days post-oviposition. The efficiency of 252 Cf neutrons for inducing wing-hair mosaic spots is very high, RBE=8.5, but that for eye-color mosaic spot is almost equal (RBE=1.2) to that of 137 Cs γ-rays. RBE-LET relationships were obtained for the induction of wing-hair and eye-color mosaic spots. The RBE of carbon and neon ions for producing wing-hair mosaic spots increased with increasing LET values. The RBE for the induction of eye-color mutants did not change with LET. These relationships suggest that more complex types of DNA damage such as non-rejoinable strand breaks or clustered double strand breaks that increase with LET may be responsible for inducing the wing-hair mutation, while simpler forms of molecular damage may induce reversion in the white-ivory allele. (author)

  12. The Effects of Students' Perceptions of Campus Safety and Security on Student Enrollment

    Science.gov (United States)

    Carrico, Brian Andrew

    2016-01-01

    The purpose of this research was to determine whether student enrollment is affected by the student perception of campus safety and security when choosing a college. As the competition for students increases among higher education institutions, it is important for higher education administrators to know how to effectively present their respective…

  13. Role of the superior colliculus in choosing mixed-strategy saccades.

    Science.gov (United States)

    Thevarajah, Dhushan; Mikulić, Areh; Dorris, Michael C

    2009-02-18

    Game theory outlines optimal response strategies during mixed-strategy competitions. The neural processes involved in choosing individual strategic actions, however, remain poorly understood. Here, we tested whether the superior colliculus (SC), a brain region critical for generating sensory-guided saccades, is also involved in choosing saccades under strategic conditions. Monkeys were free to choose either of two saccade targets as they competed against a computer opponent during the mixed-strategy game "matching pennies." The accuracy with which presaccadic SC activity predicted upcoming choice gradually increased in the time leading up to the saccade. Probing the SC with suprathreshold stimulation demonstrated that these evolving signals were functionally involved in preparing strategic saccades. Finally, subthreshold stimulation of the SC increased the likelihood that contralateral saccades were selected. Together, our results suggest that motor regions of the brain play an active role in choosing strategic actions rather than passively executing those prespecified by upstream executive regions.

  14. From Baby Bottle to Cup: Choose Training Cups Carefully, Use Them Temporarily

    Science.gov (United States)

    FOR THE DENTAL PATIENT ... From baby bottle to cup Choose training cups carefully, use them temporarily T ooth decay can ... should encourage their children to drink from a cup by their first birthday. As you make the ...

  15. Causes and Consequences of Choosing Different Assurance Providers: An International Study of Sustainability Reporting

    NARCIS (Netherlands)

    P.M. Perego (Paolo)

    2009-01-01

    textabstractAn increasing number of companies voluntary disclose information about their social and environment performance in sustainability reports. This study investigates the causes and consequences of choosing different assurance providers for companies seeking independent verification of their

  16. Leadership in nursing: analysis of the process of choosing the heads.

    Science.gov (United States)

    de Moura, Gisela Maria Schebella Souto; de Magalhaes, Ana Maria Müller; Dall'agnol, Clarice Maria; Juchem, Beatriz Cavalcanti; Marona, Daniela dos Santos

    2010-01-01

    The process of choosing heads can be strategic to achieve desired results in nursing care. This study presents an exploratory and descriptive research that aims to analyze the process of choosing heads for the ward, in the nursing area of a teaching hospital in Porto Alegre. Data was collected from registered nurses, technicians and nursing auxiliaries through a semi-structured interview technique and free choice of words. Three theme categories emerged from content analysis: process of choosing heads, managerial competences of the head-to-be and team articulation. Leadership was the word most frequently associated with the process of choosing heads. The consultation process for the choice of the leader also contributes to the success of the manager, as it makes the team members feel co-responsible for the results achieved and legitimizes the head-to-be in their group.

  17. Choosing to Fly: Examining Fear, Risk and Resilience

    KAUST Repository

    Davis, Steph

    2017-01-15

    Steph Davis was raised as a classical piano student in a traditional, academic family. She ultimately quit music and then law school, making the frightening decision to step off the safe road and follow her passion to become a full-time rock climber. In 25 years of climbing, Steph has applied the principles of discipline and practice she learned as a musician to reach the tops of some of the world\\'s most difficult rock walls and mountains, often climbing solo without a rope or safety equipment. Intrigued by the power of fear and how it affects our ability to succeed and to stay safe, she learned to skydive as a literal way to face her own fears of falling. From skydiving, Steph immersed herself in the pursuit of wingsuit BASE jumping, known as the most advanced and dangerous form of human flight, in order to fly off mountains after climbing up them. Living and surviving in the mountains and the air, Steph has developed a deep understanding of the need to adapt to one\\'s environment, to embrace failure and to come to terms with fear--skills which are also crucial for survival and success in any walk of life. After the loss of her husband on a wingsuit flight in the Dolomites, Steph saw that resilience is a choice. The decision to keep going forward and to embrace life fully in the face of loss is a simple and yet profound decision that we can all make, no matter what challenges we face. Simply by deciding that we want to go somewhere, whether physically or mentally, we\\'ve taken the first step to getting there.

  18. A composite microdose Adaptive Response (AR) and Bystander Effect (BE) model-application to low LET and high LET AR and BE data.

    Science.gov (United States)

    Leonard, Bobby E

    2008-08-01

    It has been suggested that Adaptive Response (AR) may reduce risk of adverse health effects due to ionizing radiation. But very low dose Bystander Effects (BE) may impose dominant deleterious human risks. These conflicting behaviors have stimulated controversy regarding the Linear No-Threshold human risk model. A dose and dose rate-dependent microdose model, to examine AR behavior, was developed in prior work. In the prior work a number of in vitro and in vivo dose response data were examined with the model. Recent new data show AR behavior with some evidence of very low dose BE. The purpose of this work is to supplement the microdose model to encompass the Brenner and colleagues BaD (Bystander and Direct Damage) model and apply this composite model to obtain new knowledge regarding AR and BE and illustrate the use of the model to plan radio-biology experiments. The biophysical composite AR and BE Microdose Model quantifies the accumulation of hits (Poisson distributed, microdose specific energy depositions) to cell nucleus volumes. This new composite AR and BE model provides predictions of dose response at very low dose BE levels, higher dose AR levels and even higher dose Direct (linear-quadratic) Damage radiation levels. We find good fits of the model to both BE data from the Columbia University microbeam facility and combined AR and BE data for low Linear Energy Transfer (LET) and high LET data. A Bystander Factor of about 27,000 and an AR protection factor of 0.61 are obtained for the low LET in vivo mouse spleen exposures. A Bystander Factor of 317 and an AR protection factor of 0.53 are obtained for high LET radon alpha particles in human lymphocytes. In both cases the AR is activated at most by one or two radiation induced charged particle traversals through the cell nucleus. The results of the model analysis is consistent with a premise that both Bystander damage and Adaptive Response radioprotection can occur in the same cell type, derived from the same

  19. let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex

    Directory of Open Access Journals (Sweden)

    Tsai-Tsen Liao

    2016-01-01

    Full Text Available Let-7 is crucial for both stem cell differentiation and tumor suppression. Here, we demonstrate a chromatin-dependent mechanism of let-7 in regulating target gene expression in cancer cells. Let-7 directly represses the expression of AT-rich interacting domain 3B (ARID3B, ARID3A, and importin-9. In the absence of let-7, importin-9 facilitates the nuclear import of ARID3A, which then forms a complex with ARID3B. The nuclear ARID3B complex recruits histone demethylase 4C to reduce histone 3 lysine 9 trimethylation and promotes the transcription of stemness factors. Functionally, expression of ARID3B is critical for the tumor initiation in let-7-depleted cancer cells. An inverse association between let-7 and ARID3A/ARID3B and prognostic significance is demonstrated in head and neck cancer patients. These results highlight a chromatin-dependent mechanism where let-7 regulates cancer stemness through ARID3B.

  20. A Framework Proposal For Choosing A New Business Implementation Model In Henkel

    OpenAIRE

    Li, Tsz Wan

    2015-01-01

    Henkel's New Business team is a corporate venturing unit that explores corporate entrepreneurial activities on behalf of Henkel Adhesives Technologies. The new business ideas are implemented through one of these models: incubator, venturing or innovation ecosystem. In current practice, there is no systematic framework in place to choose the implementation model. The goal of the thesis is to propose a framework for choosing the most appropriate model for implementation of a new business idea i...