Shared vision between fathers and daughters in family businesses: the determining factor that transforms daughters into successors.

Science.gov (United States)

Overbeke, Kathy K; Bilimoria, Diana; Somers, Toni

2015-01-01

Family businesses are critical to the United States economy, employing 63% of the workforce and generating 57% of GDP (University of Vermont, 2014). Family business continuity, however, remains elusive as approximately 70% of family businesses do not survive the second generation (Poza, 2013). In order to augment our understanding of how next generation leaders are chosen in family businesses, we examine daughter succession. Using a sample of pairs of family business fathers and daughters and drawing on an earlier study of the dearth of successor daughters in family businesses (Overbeke et al., 2013), we reveal that shared vision between fathers and daughters is central to daughter succession. Self-efficacy and gender norms influence shared vision and when fathers and daughters share a vision for the future of the company, daughters are likely to be transformed into successors.

VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation

International Nuclear Information System (INIS)

Fujisawa, Hiroshi; Nakajima, Nakako Izumi; Sunada, Shigeaki; Lee, Younghyun; Hirakawa, Hirokazu; Yajima, Hirohiko; Fujimori, Akira; Uesaka, Mitsuru; Okayasu, Ryuichi

2015-01-01

High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The reason why high LET radiation accomplishes greater tumor-killing than X-rays is still not completely understood. One factor would be the clustered or complex-type DNA damages. We previously reported that complex DNA double-strand breaks produced by high LET radiation enhanced DNA end resection, and this could lead to higher kinase activity of ATR protein recruited to RPA-coated single-stranded DNA. Although the effect of ATR inhibition on cells exposed to low LET gamma-rays has recently been reported, little is known regarding the effect of ATR inhibitor on cells treated with high LET radiation. The purpose of this study is to investigate the effects of the ATR inhibitor VE-821 in human tumor and normal cells irradiated with high LET carbon ions. HeLa, U2OS, and 1BR-hTERT (normal) cells were pre-treated with 1 μM VE-821 for 1 hour and irradiated with either high LET carbon ions or X-rays. Cell survival, cell cycle distribution, cell growth, and micronuclei formation were evaluated. VE-821 caused abrogation of G2/M checkpoint and forced irradiated cells to divide into daughter cells. We also found that carbon ions caused a higher number of multiple micronuclei than X-rays, leading to decreased cell survival in tumor cells when treated with VE-821, while the survival of irradiated normal cells were not significantly affected by this inhibitor. ATR inhibitor would be an effective tumor radiosensitizer with carbon ion irradiation. The online version of this article (doi:10.1186/s13014-015-0464-y) contains supplementary material, which is available to authorized users

African American mother-daughter communication about sex and daughters' sexual behavior: does college racial composition make a difference?

Science.gov (United States)

Bynum, Mia Smith

2007-04-01

This study examined the influence of African American mothers' communication about sexual topics on the sexual attitudes and behavior of their college-enrolled daughters. Daughters were enrolled at a historically Black college/university (HBCU) or a predominantly White institution (PWI) to assess whether and how college racial context might affect daughters' sexual attitudes and behavior. Findings indicated that daughters at the HBCU had less permissive attitudes about premarital sex than their counterparts at the PWI. This result was especially true for daughters of mothers with more conservative attitudes about premarital sex and who discussed such topics infrequently. Last, the combination of positive mother-daughter communication and fewer discussions about sexual topics resulted in lower levels of sexual experience among the daughters. (c) 2007 APA, all rights reserved.

Adult Daughters' Descriptions of Their Mother-Daughter Relationship in the Context of Chronic Conflict.

Science.gov (United States)

Pickering, Carolyn E Z; Mentes, Janet C; Moon, Ailee; Pieters, Huibrie C; Phillips, Linda R

2015-01-01

The purpose of this article is to describe, from the perspective of the adult daughter, the mother-daughter relationship in the context of chronic conflict. Grounded theory methodology was used. An online recruitment strategy was used to identify a sample of adult daughters (N = 13) who self-identified as having an abusive relationship with their aging mother. Data collection was completed through semi-structured telephone interviews. Daughters framed their relationship around their perceptions of past childhood injustices. These injustices invoked strong negative emotions. Daughters had equally strong motivations for sustaining the relationship, driven by desire to reconcile their negative experience through seeking validation and futile-hoping as well as a sense of obligation to do due diligence. Together these factors created an environment of inevitable confrontation and a relationship defined by chronic conflict. Findings from the study provide theoretical insights to the conceptualization of aggression, power relationships, and the development of elder abuse and neglect.

Dosimetry, measurement and properties of radon daughters and thoron daughters

International Nuclear Information System (INIS)

Phillips, C.R.

1982-03-01

Various properties of radon and thoron daughter products are examined. Dosimeter methods and instrumentation (TLD and personal alpha dosimeters) are investigated as to performance under varying conditions such as humidity and pure or mixed atmospheric conditions. Optimized counting schemes are determined for the daughters of radon and thoron. An optimized counting scheme was experimentally examined under mine conditions. The optimization procedure takes into account the uncertainties associated with concentration, flow rate and radioactive decay. Measurements were made in two uranium mines at Elliot Lake, Ontario of the charged and unattached fractions of radon daughters in the mines. The physicochemical state of 218 Po in air was determined by measurement of rate of neutralization, diffusion coefficient and fraction born charge. Careful control of experimental conditions made it possible to obtain more precise and detailed quantitative data than previously possible

Impact of Behavioral Symptoms in Dementia Patients on Depression in Daughter and Daughter-in-Law Caregivers.

Science.gov (United States)

Lee, Juwon; Sohn, Bo Kyung; Lee, Hyunjoo; Seong, Sujeong; Park, Soowon; Lee, Jun-Young

2017-01-01

One caregiver relationship that has been neglected in caregiver depression research is the daughter-in-law. Compared with Western countries, in which those who are closer in familial relationships such as the spouse or child usually take care of the patient, in many Asian countries, the daughter-in-law often assumes the caretaker role. However, not much research has been done on how this relationship may result in different caregiver outcomes. We sought to identify whether the association between patient characteristics and caregiver depressive symptoms differs according to the familial relationship between caregiver and patient. Ninety-five daughter (n = 47) and daughter-in-law (n = 48) caregivers of dementia patients were asked to report their own depressive symptoms and patient behavioral symptoms. Patients' cognitive abilities, daily activities, and global dementia ratings were obtained. Hierarchical linear regression was employed to determine predictors of depressive symptoms. Daughters-in-law had marginally higher depressive scores. After adjusting for caregiver and patient characteristics, in both groups, greater dependency in activities of daily living and more severe and frequent behavioral symptoms predicted higher caregiver depressive scores. However, greater severity and frequency of behavioral symptoms predicted depression to a greater degree in daughters compared with daughters-in-law. Although behavioral symptoms predicted depression in both caregiver groups, the association was much stronger for daughters. This suggests that the emotional relationship between the daughter and patient exacerbates the negative effect of behavioral symptoms on caregiver depression. The familial relationship between the caregiver and dementia patient should be considered in managing caregiver stress.

Radon daughter dosimeter

International Nuclear Information System (INIS)

Durkin, J.

1977-01-01

This patent describes a portable radon daughter dosimeter unit used to measure radon gas alpha daughters in ambient air. These measurements can then be related to preselected preestablished standards contained in a remote central readout unit. The dosimeter unit is adapted to be worn by an operator in areas having alpha particle radiation such as in uranium mines. Within the dosimeter is a detector head housing having a filter head and a solid state surface barrier radiation detector; an air pump to get air to the detector head; a self contained portable power supply for the unit; and electronic circuitry to process detected charged electrons from the detector head to convert and count their pulses representatives of two alpha radon emitter daughters. These counted pulses are in binary form and are sent to a readout unit where a numerical readout displays the result in terms of working level-hours

Radon daughter dosimeter

International Nuclear Information System (INIS)

Durkin, J.

1977-01-01

A portable radon daughter dosimeter unit used to measure Radon gas alpha daughters in ambient air is described. These measurements can then be related to preselected preestablished standards contained in a remote central readout unit. The dosimeter unit is adapted to be worn by an operator in areas having alpha particle radiation such as uranium mines. Within the dosimeter is a detector head housing having a filter head and a solid state surface barrier radiation detector; an air pump to get air to the detector head; a self contained portable power supply for the unit; and electronic circuitry to process detected charged electrons from the detector head to convert and count their pulses representatives of two alpha radon emitter daughters. These counted pulses are in binary form and are sent to a readout unit where a numerical readout diplays the result in terms of working level-hours

Updating radon daughter bronchial dosimetry

International Nuclear Information System (INIS)

Harley, N.H.; Cohen, B.S.

1990-01-01

It is of value to update radon daughter bronchial dosimetry as new information becomes available. Measurements have now been performed using hollow casts of the human bronchial tree with a larynx to determine convective or turbulent deposition in the upper airways. These measurements allow a more realistic calculation of bronchial deposition by diffusion. Particle diameters of 0.15 and 0.2 μm were used which correspond to the activity median diameters for radon daughters in both environmental and mining atmospheres. The total model incorporates Yeh/Schum bronchial morphometry, deposition of unattached and attached radon daughters, build up and decay of the daughters and mucociliary clearance. The alpha dose to target cells in the bronchial epithelium is calculated for the updated model and compared with previous calculations of bronchial dose

Orphan radon daughters at Denver Radium site

International Nuclear Information System (INIS)

Holub, R.F.; Droullard, R.F.; Davis, T.H.

1992-01-01

During 18 mo of sampling airborne radioactively at a National Priority List (open-quotes Superfundclose quotes) site in metroPOlitan Denver, Bureau of mines personnel discovered radon daughters that are not supported by the parent radon gas. We refer to them as open-quotes orphanclose quotes daughters because the parent, radon, is not present in sufficient concentration to support the measured daughter products. Measurements of the open-quotes orphanclose quotes daughters were made continuously, using the Bureau-developed radon and working-level (radon-daughter) monitors. The data showed high equilibrium ratios, ranging from 0.7 to 3.5, for long periods of time. Repeated, high-volume, 15-min grab samples were made, using the modified Tsivoglou method, to measure radon daughters, to which thoron daughters contributed 26 ± 12%. On average 28 ± 6% of the particulate activity was contributed by thoron daughters. Most samples were mixtures in which the 218 Po concentration was lower than that of 214 Pb and 214 Bi, in agreement with the high-equilibrium factors obtained from the continuous sampling data. In view of the short half-life of radon progeny, we conclude that the source of the orphan daughters is not far from the Superfund sites. The mechanism of this phenomenon is not understood at this time, but we will discuss its possible significance in evaluating population doses

Passive radon daughter dosimeters

International Nuclear Information System (INIS)

McElroy, R.G.C.; Johnson, J.R.

1986-03-01

On the basis of an extensive review of the recent literature concerning passive radon daughter dosimeters, we have reached the following conclusions: 1) Passive dosimeters for measuring radon are available and reliable. 2) There does not presently exist an acceptable passive dosimeter for radon daughters. There is little if any hope for the development of such a device in the foreseeable future. 3) We are pessimistic about the potential of 'semi-passive dosimeters' but are less firm about stating categorically that these devices cannot be developed into a useful radon daughter dosimeter. This report documents and justifies these conclusions. It does not address the question of the worker's acceptance of these devices because at the present time, no device is sufficiently advanced for this question to be meaningful. 118 refs

The mother-daughter love affair across the generations.

Science.gov (United States)

Klockars, L; Sirola, R

2001-01-01

The relationship between mother and daughter is the basis for all love relationships throughout life. Through the eyes and hands of the mother, the intimate and caring nature of love is transmitted from generation to generation. Mother-daughter love is also the beginning of heterosexual love and of sensual pleasure. However, sexuality separates and alienates mother and daughter. As a consequence, the daughter's identification with the mother becomes the most important transmitter of love. We review psychoanalytic studies of the development and fate of the mother-daughter love relationship, with particular attention to the change of the daughter's early love for the mother to identification with the mother and falling in love with a man, and to the significance of sexuality in this developmental process.

Radionuclide daughter inventory generator code: DIG

International Nuclear Information System (INIS)

Fields, D.E.; Sharp, R.D.

1985-09-01

The Daughter Inventory Generator (DIG) code accepts a tabulation of radionuclide initially present in a waste stream, specified as amounts present either by mass or by activity, and produces a tabulation of radionuclides present after a user-specified elapsed time. This resultant radionuclide inventory characterizes wastes that have undergone daughter ingrowth during subsequent processes, such as leaching and transport, and includes daughter radionuclides that should be considered in these subsequent processes or for inclusion in a pollutant source term. Output of the DIG code also summarizes radionuclide decay constants. The DIG code was developed specifically to assist the user of the PRESTO-II methodology and code in preparing data sets and accounting for possible daughter ingrowth in wastes buried in shallow-land disposal areas. The DIG code is also useful in preparing data sets for the PRESTO-EPA code. Daughter ingrowth in buried radionuclides and in radionuclides that have been leached from the wastes and are undergoing hydrologic transport are considered, and the quantities of daughter radionuclide are calculated. Radionuclide decay constants generated by DIG and included in the DIG output are required in the PRESTO-II code input data set. The DIG accesses some subroutines written for use with the CRRIS system and accesses files containing radionuclide data compiled by D.C. Kocher. 11 refs

Mechanism and significance of let-7 in diagnosis and treatment of hepatocellular carcinoma

Directory of Open Access Journals (Sweden)

HUO Tingting

2017-07-01

Full Text Available Abstract:MicroRNA (miRNA play important roles in post-transcriptional gene regulation. In recent years, miRNA has become a hot topic in the research on the development and progression of tumors, and gene targeting therapy for malignant tumors has achieved preliminary progress. As one of the first discovered miRNA, let-7 can regulate the cell cycle and angiogenesis and is involved in the proliferation, differentiation, and apoptosis of various tumor cells. Most members of the let-7 family can act as tumor suppressor gene and have low expression in various tumor tissues and high expression in the serum of patients with malignant tumors. Let-7 is closely associated with the invasion and drug resistance of hepatocellular carcinoma (HCC. The studies above show that let-7 might become a new marker for the early diagnosis of HCC and provide new targets for the treatment of HCC.

Do mothers affect daughter's behaviors? Diet, physical activity, and sedentary behaviors in Kuwaiti mother-daughter dyads.

Science.gov (United States)

Shaban, Lemia H; Vaccaro, Joan A; Sukhram, Shiryn D; Huffman, Fatma G

2018-01-01

The objective of the study was to evaluate 169 Kuwaiti mother-daughter dyads and their associations with health behaviors for eating healthy, engaging in physical activity, daughters perceived body weight, time spent with computer/video, and time viewing television. Female students aged 10-14 years were selected from private and public schools in the State of Kuwait. Results demonstrated that daughters exhibited similar behaviors to their mothers in their perceived eating behavior, physical activity, computer/video game use, and TV screen time. Future research is essential to determine the role of mothers in effective health behavior intervention strategies for female Kuwaiti adolescents.

Personal radon daughter dosimetry

International Nuclear Information System (INIS)

Stocker, H.

1979-12-01

The conventional means of radon daughter exposure estimatikn for uranium miners in Canada is by grab sampling and time weighting. Personal dosimetry is a possible alternative method with its own advantages and limitations. The author poses basic questions with regard to two methods of radon daughter detection, thermoluminescent chips and track-etch film. An historical review of previous and current research and development programs in Canada and in other countries is presented, as are brief results and conclusions of each dosimeter evaluation

Disturbance from Am-241 Photons of the Cellular Dose by Am-241 Alpha Emissions: Am-241 as an alternative source of alpha particles to radon daughters

International Nuclear Information System (INIS)

Lee, Ki-Man; Kim, Eun-Hee

2015-01-01

The Radiation Bioengineering Laboratory (RadBio Lab) at Seoul National University (SNU) has built an Am-241 alpha particle irradiator for study of cellular responses to radiation from radon daughters. The radon daughters of concern that cause internal exposure from inhalation of radon-contaminated air are Po-218, Po-214 and Po-210. In their alpha decay schemes, the yields of photon emissions are negligible. Unfortunately, Am-241, the source of alpha irradiator in RadBio Lab, emits photons at every alpha decay while transforming to Np-237 of long half-life. Employing Am-241 as the source simulating radon daughters, therefore, requires that photon emissions from Am-241 be specified in term of dose contribution. In this study, Monte Carlo calculations have been made to characterize dose contributions of Am-241 photon emissions. This study confirms that disturbance from Am-241 photon emissions of the cellular dose by Am-241 alpha emissions is negligible. Dose contamination fraction from photon emissions was 8.02 .. 10 -6 at 25 mm SSD at maximum. Also, note that LET in tissue-equivalent medium varies within about 20% for alpha particles at energies over 5 MeV

Health hazards due to radon and its daughters

International Nuclear Information System (INIS)

Khan, H.A.; Qureshi, I.E.; Tufail, M.

1993-01-01

The health hazards liked to radon and its daughters have become a matter of great public concern. When inhaled, a fraction of radon is dissolved into the lung fluid, from where it is transported to other parts of the body. The radiation damage is caused to the lungs due to alpha decay of radon during its transit time within the respiratory tract. Radon daughters are found to be even more dangerous than radon itself. These daughters attach themselves to dust particles present in the air. Some of the aerosols so produced enter the lungs and enter the blood stream. It has now been confirmed that radon and its daughters contribute about 70% of the internal dose received by an individual from natural radiation sources. The danger of indoor radon and its daughters is even higher for energy-saving houses and those having poor ventilation systems. This paper briefly describes the health hazards due to radon and its daughters. Different methods employed for the measurement of concentrations of radon and their daughters are described. The experience gained from the nation-wide surveys carried out in different countries is also given. (author). 18 refs, 3 figs, 1 tab

Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation

International Nuclear Information System (INIS)

Supiot, Stephane; Thillays, Francois; Rio, Emmanuel; Gouard, Sebastien; Morgenstern, Alfred; Bruchertseifer, Frank; Mahe, Marc-Andre; Chatal, Jean-Francois; Davodeau, Francois; Cherel, Michel

2007-01-01

The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT 213 Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET

FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans

Directory of Open Access Journals (Sweden)

Dentler William L

2008-05-01

Full Text Available Abstract Background In the C. elegans germ line, syncytial germ line nuclei are arranged at the cortex of the germ line as they exit mitosis and enter meiosis, forming a nucleus-free core of germ line cytoplasm called the rachis. Molecular mechanisms of rachis formation and germ line organization are not well understood. Results Mutations in the fli-1 gene disrupt rachis organization without affecting meiotic differentiation, a phenotype in C. elegans referred to here as the germ line morphogenesis (Glm phenotype. In fli-1 mutants, chains of meiotic germ nuclei spanned the rachis and were partially enveloped by invaginations of germ line plasma membrane, similar to nuclei at the cortex. Extensions of the somatic sheath cells that surround the germ line protruded deep inside the rachis and were associated with displaced nuclei in fli-1 mutants. fli-1 encodes a molecule with leucine-rich repeats and gelsolin repeats similar to Drosophila flightless 1 and human Fliih, which have been shown to act as cytoplasmic actin regulators as well as nuclear transcriptional regulators. Mutations in let-60 Ras, previously implicated in germ line development, were found to cause the Glm phenotype. Constitutively-active LET-60 partially rescued the fli-1 Glm phenotype, suggesting that LET-60 Ras and FLI-1 might act together to control germ line morphogenesis. Conclusion FLI-1 controls germ line morphogenesis and rachis organization, a process about which little is known at the molecular level. The LET-60 Ras GTPase might act with FLI-1 to control germ line morphogenesis.

Removal of radon daughters from indoor air

International Nuclear Information System (INIS)

Jonassen, N.

1985-01-01

The internal radiological exposure of the general population is largely due to the airborne daughter products of radon and thoron, which are found in two states, attached to aerosols or unattached, of which the latter species according to several dose models have the highest radiological dose efficiency of the two. The radon daughters may be removed from indoor air by a series of processes like ventilation, filtration, plateout, and electrostatic deposition. Ventilation (with radon-free air) is, on the one hand, a very effective measure, but usually involves introduction of colder air, in variance with energy-saving efforts. Internal filtration will not affect the radon concentration but may reduce the level of daughter activities, roughly inversely proportional to the filtration rate. At the same time, however, filtration may also change the aerosol distribution and concentration of the air and, consequently, the partitioning of the radon daughters between the attached and unattached state. This, in turn, influences the rate of deposition of radon daughters both by diffusional plateout and as an effect of an electric field. Experiments are reported demonstrating reductions in the airborne potential alpha energy by factors of 4 to 5 by use of filtration rates of 3-4 times per hour. In case of low aerosol concentrations, however, the corresponding reduction in radiological dose to critical parts of the respiratory tract may be much smaller, due to the shift toward higher fractions of the radon daughters being in the unattached state caused by the filtration. The possibility of using electrostatic deposition of radon daughters is also discussed

Parents' personality clusters and eating disordered daughters' personality and psychopathology.

Science.gov (United States)

Amianto, Federico; Ercole, Roberta; Marzola, Enrica; Abbate Daga, Giovanni; Fassino, Secondo

2015-11-30

The present study explores how parents' personality clusters relate to their eating disordered daughters' personality and psychopathology. Mothers and fathers were tested with the Temperament Character Inventory. Their daughters were assessed with the following: Temperament and Character Inventory, Eating Disorder Inventory-2, Symptom Checklist-90, Parental Bonding Instrument, Attachment Style Questionnaire, and Family Assessment Device. Daughters' personality traits and psychopathology scores were compared between clusters. Daughters' features were related to those of their parents. Explosive/adventurous mothers were found to relate to their daughters' borderline personality profile and more severe interoceptive awareness. Mothers' immaturity was correlated to their daughters' higher character immaturity, inadequacy, and depressive feelings. Fathers who were explosive/methodic correlated with their daughters' character immaturity, severe eating, and general psychopathology. Fathers' character immaturity only marginally related to their daughters' specific features. Both parents' temperament clusters and mothers' character clusters related to patients' personality and eating psychopathology. The cluster approach to personality-related dynamics of families with an individual affected by an eating disorder expands the knowledge on the relationship between parents' characteristics and daughters' illness, suggesting complex and unique relationships correlating parents' personality traits to their daughters' disorder. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

A field method for monitoring thoron-daughter working level

International Nuclear Information System (INIS)

Khan, A.H.; Dhandayatham, R.; Raghavayya, M.; Nambiar, P.P.V.J.

1975-01-01

The concept of working level, generally used for radon daughters, has been extended to the daughter products of thoron. Accordingly, thorondaughter working level (TWL) has been defined as the alpha energy released from the ultimate decay of 100 pCi/1 each of the short-lived decay products of thoron. In order to facilitate the evaluation of inhalation hazard in thorium handling areas, a simple field method has been suggested to measure the thoron-daughter working level. A comparison of the potential alpha energies from radon-daughters and that from thoron-daughter is included. (K.B.)

Aging mothers' and their adult daughters' perceptions of conflict behaviors.

Science.gov (United States)

Fingerman, K L

1995-12-01

Aging parents tend to perceive greater compatibility between themselves and offspring than do off-spring, but there is little research examining differences in perceptions of conflicts. Ninety-six older mothers (M age = 76) and their daughters (M age = 44) together selected a conflictual incident, then individually rated the degree to which they and the other person had engaged in destructive, constructive, or avoidant conflict behaviors. Mothers and daughters reported using constructive approaches more than other approaches. Mothers claimed to engage in constructive behaviors more than daughters recognized. Daughters reported engaging in destructive and avoidant behaviors more than mothers realized. Mothers also thought daughters felt better about the incident than daughters reported feeling about it. Findings suggest older mothers' underestimate daughters' negative behaviors and feelings in conflict situations.

Lilavatis Daughters | Women in Science | Initiatives | Indian ...

Indian Academy of Sciences (India)

Home; Initiatives; Women in Science; Lilavatis Daughters ... The book 'Lilavati's Daughters: The Women Scientists of India' was successfully ... Charusita Chakravarty, one of the stars of our community of women scientists, at a young age of 52, ...

Reproductive prognosis in daughters of women with and without endometriosis

DEFF Research Database (Denmark)

Dalsgaard, T; Hansen, Maj Vadskjær Hjordt; Hartwell, D

2013-01-01

Do daughters of women with endometriosis exhibit an increased risk of endometriosis and impaired long-term reproductive prognosis when compared with daughters of women without endometriosis?......Do daughters of women with endometriosis exhibit an increased risk of endometriosis and impaired long-term reproductive prognosis when compared with daughters of women without endometriosis?...

Mother-daughter in vitro fertilization triplet surrogate pregnancy.

Science.gov (United States)

Michelow, M C; Bernstein, J; Jacobson, M J; McLoughlin, J L; Rubenstein, D; Hacking, A I; Preddy, S; Van der Wat, I J

1988-02-01

A successful triplet pregnancy has been established in a surrogate gestational mother following the transfer of five embryos fertilized in vitro. The oocytes were donated by her biological daughter, and the sperm obtained from the daughter's husband. The daughter's infertility followed a total abdominal hysterectomy performed for a postpartum hemorrhage as a result of a placenta accreta. Synchronization of both their menstrual cycles was obtained using oral contraceptive suppression for 2 months, followed by stimulation of both the surrogate gestational mother and her daughter such that embryo transfer would occur at least 48 hr after the surrogate gestational mother's own ovulation. This case raises a number of medical, social, psychological, and ethical issues.

Radon and its daughters in vivo

International Nuclear Information System (INIS)

Rundo, J.

1983-01-01

Some aspects of the behavior of radon and its short-lived daughters in vivo are described and a relationship between the radon exhalation rate and time after a meal is demonstrated. A major but short-lived postprandial increase in the exhalation rate of radon produced from skeletally-deposited radium was observed and a similar effect in exhalation rate of environmental radon by persons containing no radium was noted. Persons living in houses with elevated concentrations of radon may contain sufficient activity for its detection by external gamma-ray counting. Some of the activity observed is due to inhaled daughter-products in the chest, and some to daughter-products associated with and produced by the decay of radon throughout the body. 3 references, 8 figures. (MF)

LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring.

Science.gov (United States)

Price, Kari L; Rose, Lesilee S

2017-09-01

The anaphase spindle determines the position of the cytokinesis furrow, such that the contractile ring assembles in an equatorial zone between the two spindle poles. Contractile ring formation is mediated by RhoA activation at the equator by the centralspindlin complex and midzone microtubules. Astral microtubules also inhibit RhoA accumulation at the poles. In the Caenorhabditis elegans one-cell embryo, the astral microtubule-dependent pathway requires anillin, NOP-1, and LET-99. LET-99 is well characterized for generating the asymmetric cortical localization of the Gα-dependent force-generating complex that positions the spindle during asymmetric division. However, whether the role of LET-99 in cytokinesis is specific to asymmetric division and whether it acts through Gα to promote furrowing are unclear. Here we show that LET-99 contributes to furrowing in both asymmetrically and symmetrically dividing cells, independent of its function in spindle positioning and Gα regulation. LET-99 acts in a pathway parallel to anillin and is required for myosin enrichment into the contractile ring. These and other results suggest a positive feedback model in which LET-99 localizes to the presumptive cleavage furrow in response to the spindle and myosin. Once positioned there, LET-99 enhances myosin accumulation to promote furrowing in both symmetrically and asymmetrically dividing cells. © 2017 Price and Rose. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Control of radon daughters in underground mining

International Nuclear Information System (INIS)

Swent, L.W.

1983-01-01

This paper discusses technical developments that may enable uranium mine operators to improve engineering controls of radon daughter concentrations in mines, and developments in regulatory controls. The origin of radon daughters in underground mines is explained. The procedure for sampling and determining the concentration of alpha radiation in sampled air is reviewed. The principal technical development in the last few years has been the perfection and use of a class of meters which determine radon daughter concentrations in an air sample in a matter of two or three minutes without any aging period. A number of underground uranium mine operators are now using ''instant'' type meters and the Mine Safety and Health Administration (MSHA) has approved their use in a number of mines. The difficulty experienced by uranium mine operators in complying with a MSHA regulation which requires that no person be exposed to radon daughter concentrations exceeding 1 Working Level (WL) in any active working place is discussed

A Case Report on Management of Father Daughter Incest with Schizophrenia

Directory of Open Access Journals (Sweden)

Tanjir Rashid Soron

2016-01-01

Full Text Available Incest is a neglected and hidden public health problem. This case is about a patient who was victim of sexual abuse, suffered from schizophrenia and abused his biological daughter. He was physically and sexually abused by seniors and classmates, developed paranoid delusion and auditory hallucination. During the course of the illness, he was hospitalized several times as a case of schizophrenia and sexual dysfunction was his main concern. The patient’s illness followed a waxing and waning course. He took medication on on-and-off basis. He abused his biological daughter sexually at the later stage of the illness. Ultimately, the patient attempted suicide after an indecent sexual act with another relative and he was admitted to the hospital. He was treated with risperidone that was titrated to 10 mg per day. After continuing the medication for 2 years he regained a functioning life and remained stable with medication. This case shows the importance of exploring the sexual behavior of the patients and sharing the experience may help in the treatment of schizophrenia patients with incest.

Factors influencing indoor concentrations of radon and daughter products

International Nuclear Information System (INIS)

Wang Hengde

1985-01-01

The correlation between indoor concentrations of 222 Rn and its daughters and some influencing factors is discussed and expressions of concentrations are derived with relation to radon exhalation rate from indoor surfaces, air exchange rate and daughter deposition velocities on indoor surfaces. Experimental methods for determining radon exhalation rate, air exchange rate and daughter deposition velocities are also mentioned

Effects of let-7b and TLX on the proliferation and differentiation of retinal progenitor cells in vitro.

Science.gov (United States)

Ni, Ni; Zhang, Dandan; Xie, Qing; Chen, Junzhao; Wang, Zi; Deng, Yuan; Wen, Xuyang; Zhu, Mengyu; Ji, Jing; Fan, Xianqun; Luo, Min; Gu, Ping

2014-10-20

MicroRNAs manifest significant functions in brain neural stem cell (NSC) self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. Let-7b is expressed in the mammalian brain and regulates NSC proliferation and differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal. Whether let-7b and TLX act as important regulators in retinal progenitor cell (RPC) proliferation and differentiation remains unknown. Here, our data show that let-7b and TLX play important roles in controlling RPC fate determination in vitro. Let-7b suppresses TLX expression to negatively regulate RPC proliferation and accelerate the neuronal and glial differentiation of RPCs. The overexpression of let-7b downregulates TLX levels in RPCs, leading to reduced RPC proliferation and increased neuronal and glial differentiation, whereas antisense knockdown of let-7b produces robust TLX expression,enhanced RPC proliferation and decreased differentiation. Moreover, the inhibition of endogenous TLX by small interfering RNA suppresses RPC proliferation and promotes RPC differentiation. Furthermore, overexpression of TLX rescues let-7b-induced proliferation deficiency and weakens the RPC differentiation enhancement caused by let-7b alone. These results suggest that let-7b, by forming a negative feedback loop with TLX, provides a novel model to regulate the proliferation and differentiation of retinal progenitors in vitro.

High-let radiation carcinogenesis

International Nuclear Information System (INIS)

Fry, R.J.M.; Powers-Risius, P.; Alpen, E.L.; Ainsworth, E.J.; Ullrich, R.L.

1982-01-01

Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20 to 30 rads

New ICRP recommendations on occupational limits for radon daughters

International Nuclear Information System (INIS)

Jacobi, W.

1981-01-01

The ICRP has recommended in 1959 for the first time a maximum permissible concentration (MPC) for the occupational exposure to radon and its short-lived daughters. Since this time more realistic dosimetric models for radon daughters have been developed. Taking into account epidemiological and new dosimetric findings the ICRP has adopted in March this year new recommendations on occupational limits for inhalation of 222 Rn, 220 Rn and their short-lived daughters. This report will be published this year as ICRP Publication 32 (ICRP 1981). The recommended limits for radon daughters were derived from the basic dose and risk limits as they were proposed by ICRP in its new basic recommendations (ICRP Publ. 26, 1977). In the following this basic system of dose limitation is shortly outlined before the special recommendations for radon daughters are described

Perspective on cancer and radon daughters

International Nuclear Information System (INIS)

Archer, V.E.

1981-01-01

This paper discusses the hazards from radon and its daughters in the environment and the role they may play in contributing to the general cancer burden. Only in exceptional circumstances can one pick out one mutagen or one carcinogen and scientifically determine what its contribution is o our burden of birth defects and cancer. The risks associated with radon and its daughters are examined in light of this philosophy

Radon/radon-daughter measurement methods and instrumentation

International Nuclear Information System (INIS)

Rock, R.L.

1977-01-01

Radon-daughter measurement equipment and techniques have been continuously improved over the last 25 years. Improvements have been in the areas of accuracy, time and convenience. We now have miniaturized scalers and detectors available for measuring the alpha particle count rates from aerosol samples collected on filter papers. We also have small lightweight efficient pumps for conveniently collecting samples and we have various counting methods which allow us to choose between making very precise measurements or nominal measurements. Radon-daughter measurement methods used in uranium mines and mills are discussed including a personal radon-daughter-exposure integrating device which can be worn by miners

Radon-daughter chamber instrumentation system reference manual

International Nuclear Information System (INIS)

Showalter, R.; Johnson, L.

1985-01-01

The radon-daughter chamber instrumentation system collects environmental data from the radon-daughter chamber. These data are then recorded on a Tandberg system tape cartridge and transmitted to the HP-1000 computer for processing. Generators which inject radon and condensation nuclei into the chamber are also included with the instrumentation system

Teenage Daughters as a Cause of Divorce

NARCIS (Netherlands)

Kabátek, Jan; Ribar, David C.

2017-01-01

Evidence from the U.S. that couples with daughters are more likely to divorce than couples with sons has not been found for other Western countries. Using 1995-2015 Dutch marriage registry data, we show that daughters are associated with higher divorce risks, but only when they are 13 to 18 years

RBE-LET relationships of high-LET radiations in drosophila mutations

International Nuclear Information System (INIS)

Yoshikawa, Isao; Takatsuji, Toshihiro; Nagano, Masaaki; Takada, Jun; Endo, Satoru; Hoshi, Masaharu

1999-01-01

The relative biological effectiveness (RBE) of 252 Cf neutrons and synchrotron-generated high-energy charged particles for mutation induction was evaluated as a function of linear energy transfer (LET), using the loss of heterozygosity for wing-hair mutations and the reversion of the mutant white-ivory eye-color in Drosophila melanogaster. Loss of heterozygosity for wing-hair mutations results predominantly from mitotic crossing over induced in wing anlage cells of larvae, while the reverse mutation of eye-color is due to an intragenic structural change (2.96 kb-DNA excision) in the white locus on the X-chromosome. The measurements were performed in a combined mutation assay system so that induced mutant wing-hair clones as well as revertant eye-color clone can be detected simultaneously in the same individual. Larvae were irradiated at the age of 3 days post oviposition with 252 Cf neutrons, carbon beam or neon beam. For the neutron irradiation, the RBE values for wing-hair mutations were larger than that for eye-color mutation by about 7 fold. The RBE of carbon ions for producing the wing-hair mutations increased with increase in LET. The estimated RBE values were found to be in the range 2 to 6.5 for the wing-hair. For neon beam irradiation, the RBE values for wing-hair mutations peak near 150 keV/μm and decrease with further increase in LET. On the other hand, the RBE values for the induction of the eye-color mutation are nearly unity in 252 Cf neutrons and both ions throughout the LET range irradiated. We discuss the relationships between the initial DNA damage and LET in considering the mechanism of somatic mutation induction. (author)

Giving Our Daughters What We Never Received: African American Mothers Discussing Sexual Health With Their Preadolescent Daughters.

Science.gov (United States)

Grigsby, Sheila R

2018-04-01

African American girls experience disparate rates of pregnancy and acquisition of sexually transmitted infections, including human immunodeficiency virus, when compared to their non-Hispanic White counterparts. Among African American girls, current pregnancy rates are equal to the national crisis levels of teen pregnancy reported in 1990. This qualitative elicitation study was conducted to gain insight into the ways in which African American mothers and their daughters, between the ages of 9 and 14, communicate about sexual health. Early sexual health communication between mothers and daughters is known to enhance the sexual health outcomes of girls. A series of four focus groups and three in-depth interviews were conducted between July and September 2014. The theory of planned behavior was the organizing framework. Theoretical constructs that guided this study were attitudes, perceived behavioral control, and subjective norms. Results showed that what African American women share with their daughters about sexual health stems from their personal faith, values, and experiences. Findings from this study can inform interventions to provide support for this understudied population. Moreover, there are implications for health-care providers, particularly school nurses, who are in an ideal position to help increase mothers' self-efficacy to engage in sexual health conversations with their young daughters.

Radon and its daughters in various British mines

International Nuclear Information System (INIS)

Strong, J.C.; Laidlaw, A.J.; O'Riordan, M.C.

1975-11-01

The results of surveys of radon and radon daughter concentrations in a large number of mines, other than coal mines, in Great Britain are presented. Measurement methods are described, and estimates of the average radon daughter concentrations are given. A comparison is made between the results of radon and radon daughter determination. The radon daughter exposure of about 40% of the non-coal miners covered by a survey in 1973 was estimated to be above the recommended limit of 4 WLM in a year. Recommendations were made for reducing this exposure and for radiological surveillance. A follow-up survey shows some improvement partly due to the implementation of these recommendations, and by October 1975, the number of miners estimated to have an annual exposure above the recommended limit had fallen to about 30% of those included in the survey. (author)

Residential radon daughter monitor based on alpha spectroscopy

International Nuclear Information System (INIS)

Nazaroff, W.W.

1980-05-01

The radioactive daughters of radon-222 pose a serious indoor air quality problem in some circumstances. A technique for measuring the concentrations of these radioisotopes in air is presented. The method involves drawing air through a filter; then, for two time intervals after sampling, counting the alpha decays from polonium-218 and polonium-214 on the filter. The time intervals are optimized to yield the maximum resolution between the individual daughter concentrations. For a total measurement time of 50 minutes, individual daughter concentrations of 1.0 nanocuries per cubic meter are measured with an uncertainty of 20%. A prototype of a field monitor based on this technique is described, as is a field test in which the prototype was used to measure radon daughter concentrations as a function of ventilation conditions in an energy-efficient house

Radon daughters and work at display devices

International Nuclear Information System (INIS)

Falk, R.; Nyblom, L.

1986-01-01

It has been shown that ions and electrically charged particles in the air can be transported in the electrostatic field between a face and a display device to either the face or the screen. Radon daughters can occur as ions, or sitting on charged particles. This prestudy shows that radon daughters were manifold concentrated on the face of a doll placed in front of a display device, or in a electrostatic field of the kind typical for displaying devices. The radiation dose, in the skin from the radon daughters in an ordinary office environment plus the addition caused by work at a display device, is not strong enough to cause skin damages alone. (BoK)

LET-effects in DNA

International Nuclear Information System (INIS)

Kraft, G.; Taucher-Scholz, G.; Heilmann, J.

1995-01-01

The use of heavy particles in radiobiological experiments provides a fundamental tool to study the influence of different ionization densities and to prove the physical basis of models and theories. The knowledge of the interaction of high LET radiation (LET: linear energy transfer [keV/microm]) with biological matter is of great importance for the application of neutrons, protons and heavier ions in radiotherapy. It is also essential in radioprotection to estimate the risk in case of exposure to high LET radiation. In this contribution, an introductory view on the physical properties of ions is given and the cellular response to high LET radiation is summarized. Then the measurements of strand break induction of DNA in solution and in intracellular DNA are reported and compared to cell survival. The possibility of changes in the quality of the lesions is discussed and finally the present status of model calculations in comparison to the experiments is given

Communication about sex and HPV among Puerto Rican mothers and daughters.

Science.gov (United States)

Colón-López, Vivian; Fernández-Espada, Natalie; Vélez, Camille; Gonzalez, Velda J; Diaz-Toro, Elba C; Calo, William A; Savas, Lara S; Pattatucci, Angela; Fernández, María E

2017-08-01

Although opportunities to vaccinate against human papillomavirus (HPV) are available, vaccination rates in Puerto Rico remain low. Communication between parents and adolescents about sexual topics may influence decisions about HPV vaccination uptake, particularly among young women; yet, few studies have addressed this issue. This qualitative study explored Puerto Rican mothers' and daughters' communication on sex-related topics, and HPV, including the HPV vaccine. Thirty participants, including 9 mothers and 21 daughters, participated in seven focus groups. Participants were divided into groups of mothers and daughters, and further stratified by vaccination status. Transcripts were analyzed using a modified grounded theory approach to identify emergent themes. Focus group data revealed four main themes: (1) limited parent-daughter communication about sex-related topics; (2) daughters' discomfort discussing sex-related topics with their parents; (3) parental focus on abstinence; and, (4) limited parent-daughter communication about HPV and the HPV vaccine. Although daughters in this study struggled with feelings of embarrassment, invasion of privacy, encouragement of abstinence, and the fear of parents' reaction to them being sexually active prior to marriage, they also recognized the need to increase the parent-daughter communication about sex-related topics including HPV and the HPV vaccine. Educational efforts should target both daughters and parents to increase communication skills and self-efficacy and to enable them to discuss sexual health in open and nonjudgmental conversations.

Comparison of two methods for investigating indoor radon daughters

International Nuclear Information System (INIS)

Vanmarcke, H.; Raes, F.

1988-01-01

The dynamics of radon daughters in realistic indoor environments has been investigated experimentally at the Universities of Gottingen and Gent. Both studies yielded the important result that the fraction of unattached radon daughters is higher than is assumed in earlier studies. Reineking-Porstendorfer and Vanmarcke-Raes adopted quite different methodologies to determine the unattached fraction. In this paper the methodologies are compared by means of joint measurements performed in a house with elevated radon concentrations. The results for the attachment rate, the deposition rate of the unattached daughters and the unattached fraction differ significantly, while the results for the deposition rate of the attached daughters and the equilibrium factor broadly agree. (author)

Gene conversion in yeast as a function of linear energy transfer (LET) for low-LET radiation

International Nuclear Information System (INIS)

Unrau, P.; Morrison, D.P.; Johnson, J.R.

1992-05-01

The relative biological effectiveness (RBE) for low-LET radiation is known to depend on such factors as LET and dose rate. Microdosimetric calculations indicate that the biological target size could also be an important parameter, and calculations predict that the RBE for effects produced by hits in target sizes below about 100 nm should be unity for all low LET radiation. We have measured that RBE for gene conversion in yeast (a small target) for five different low LET photon sources, and the results were consistent with an RBE of unity, which agrees with microdosimetric predictions. 4 refs

Heritability of menopausal age in mothers and daughters

NARCIS (Netherlands)

van Asselt, Kristel M.; Kok, Helen S.; Pearson, Peter L.; Dubas, Judith S.; Peeters, Petra H. M.; te Velde, Egbert R.; van Noord, Paulus A. H.

2004-01-01

Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs

Paternal smoking habits affect the reproductive life span of daughters

DEFF Research Database (Denmark)

Fukuda, Misao; Fukuda, Kiyomi; Shimizu, Takashi

2011-01-01

The present study assessed whether the smoking habits of fathers around the time of conception affected the period in which daughters experienced menstrual cycles (i.e., the reproductive life span). The study revealed that the smoking habits of the farther shortened the daughters' reproductive life...... span compared with daughters whose fathers did not smoke....

Randon daughter exposure of the U.K. population

International Nuclear Information System (INIS)

Cliff, K.D.

1980-01-01

The highest dose to the body tissues from natural radioactivity is that to the bronchial epithelium arising predominantly from the short-lived daughters of 222 Rn with a lesser contribution from the daughters of 220 Rn. This paper discusses the estimation of current United Kingdom population exposure to these nuclides. At present the exposure for an average member of the population of the UK is 0.15 WLM y -1 when the winter ventilation rate is 0.8 h -1 . This will increase to 0.58 WLM y -1 if the winter ventilation rate is reduced to 0.2 h -1 . The use of electrostatic precipitators would decrease the measured WL but would not affect the unattached fraction of 222 Rn daughter products, which determines the dose to the epithelium. Other methods of reducing 222 Rn daughter concentrations under investigation include prevention of the ingress of 222 Rn from the subsoil and the coating of construction materials with a radon barrier

Mother/Daughter Relationship: Psychological Implication of Love in ...

African Journals Online (AJOL)

This paper re-examines Toni Morrison's Beloved to identify an example of the types of mother/daughter relationship that existed between black mothers and their daughters and the implications of such relationship on the Black American society. The paper is a psychoanalytic reading, utilizing Melanie Klein's Object ...

Daughter-specific transcription factors regulate cell size control in budding yeast.

Science.gov (United States)

Di Talia, Stefano; Wang, Hongyin; Skotheim, Jan M; Rosebrock, Adam P; Futcher, Bruce; Cross, Frederick R

2009-10-01

In budding yeast, asymmetric cell division yields a larger mother and a smaller daughter cell, which transcribe different genes due to the daughter-specific transcription factors Ace2 and Ash1. Cell size control at the Start checkpoint has long been considered to be a main regulator of the length of the G1 phase of the cell cycle, resulting in longer G1 in the smaller daughter cells. Our recent data confirmed this concept using quantitative time-lapse microscopy. However, it has been proposed that daughter-specific, Ace2-dependent repression of expression of the G1 cyclin CLN3 had a dominant role in delaying daughters in G1. We wanted to reconcile these two divergent perspectives on the origin of long daughter G1 times. We quantified size control using single-cell time-lapse imaging of fluorescently labeled budding yeast, in the presence or absence of the daughter-specific transcriptional regulators Ace2 and Ash1. Ace2 and Ash1 are not required for efficient size control, but they shift the domain of efficient size control to larger cell size, thus increasing cell size requirement for Start in daughters. Microarray and chromatin immunoprecipitation experiments show that Ace2 and Ash1 are direct transcriptional regulators of the G1 cyclin gene CLN3. Quantification of cell size control in cells expressing titrated levels of Cln3 from ectopic promoters, and from cells with mutated Ace2 and Ash1 sites in the CLN3 promoter, showed that regulation of CLN3 expression by Ace2 and Ash1 can account for the differential regulation of Start in response to cell size in mothers and daughters. We show how daughter-specific transcriptional programs can interact with intrinsic cell size control to differentially regulate Start in mother and daughter cells. This work demonstrates mechanistically how asymmetric localization of cell fate determinants results in cell-type-specific regulation of the cell cycle.

Daughter-Specific Transcription Factors Regulate Cell Size Control in Budding Yeast

Science.gov (United States)

Di Talia, Stefano; Wang, Hongyin; Skotheim, Jan M.; Rosebrock, Adam P.; Futcher, Bruce; Cross, Frederick R.

2009-01-01

In budding yeast, asymmetric cell division yields a larger mother and a smaller daughter cell, which transcribe different genes due to the daughter-specific transcription factors Ace2 and Ash1. Cell size control at the Start checkpoint has long been considered to be a main regulator of the length of the G1 phase of the cell cycle, resulting in longer G1 in the smaller daughter cells. Our recent data confirmed this concept using quantitative time-lapse microscopy. However, it has been proposed that daughter-specific, Ace2-dependent repression of expression of the G1 cyclin CLN3 had a dominant role in delaying daughters in G1. We wanted to reconcile these two divergent perspectives on the origin of long daughter G1 times. We quantified size control using single-cell time-lapse imaging of fluorescently labeled budding yeast, in the presence or absence of the daughter-specific transcriptional regulators Ace2 and Ash1. Ace2 and Ash1 are not required for efficient size control, but they shift the domain of efficient size control to larger cell size, thus increasing cell size requirement for Start in daughters. Microarray and chromatin immunoprecipitation experiments show that Ace2 and Ash1 are direct transcriptional regulators of the G1 cyclin gene CLN3. Quantification of cell size control in cells expressing titrated levels of Cln3 from ectopic promoters, and from cells with mutated Ace2 and Ash1 sites in the CLN3 promoter, showed that regulation of CLN3 expression by Ace2 and Ash1 can account for the differential regulation of Start in response to cell size in mothers and daughters. We show how daughter-specific transcriptional programs can interact with intrinsic cell size control to differentially regulate Start in mother and daughter cells. This work demonstrates mechanistically how asymmetric localization of cell fate determinants results in cell-type-specific regulation of the cell cycle. PMID:19841732

Daughter-specific transcription factors regulate cell size control in budding yeast.

Directory of Open Access Journals (Sweden)

Stefano Di Talia

2009-10-01

Full Text Available In budding yeast, asymmetric cell division yields a larger mother and a smaller daughter cell, which transcribe different genes due to the daughter-specific transcription factors Ace2 and Ash1. Cell size control at the Start checkpoint has long been considered to be a main regulator of the length of the G1 phase of the cell cycle, resulting in longer G1 in the smaller daughter cells. Our recent data confirmed this concept using quantitative time-lapse microscopy. However, it has been proposed that daughter-specific, Ace2-dependent repression of expression of the G1 cyclin CLN3 had a dominant role in delaying daughters in G1. We wanted to reconcile these two divergent perspectives on the origin of long daughter G1 times. We quantified size control using single-cell time-lapse imaging of fluorescently labeled budding yeast, in the presence or absence of the daughter-specific transcriptional regulators Ace2 and Ash1. Ace2 and Ash1 are not required for efficient size control, but they shift the domain of efficient size control to larger cell size, thus increasing cell size requirement for Start in daughters. Microarray and chromatin immunoprecipitation experiments show that Ace2 and Ash1 are direct transcriptional regulators of the G1 cyclin gene CLN3. Quantification of cell size control in cells expressing titrated levels of Cln3 from ectopic promoters, and from cells with mutated Ace2 and Ash1 sites in the CLN3 promoter, showed that regulation of CLN3 expression by Ace2 and Ash1 can account for the differential regulation of Start in response to cell size in mothers and daughters. We show how daughter-specific transcriptional programs can interact with intrinsic cell size control to differentially regulate Start in mother and daughter cells. This work demonstrates mechanistically how asymmetric localization of cell fate determinants results in cell-type-specific regulation of the cell cycle.

Mortality and indoor radon daughter concentrations in 13 Canadian cities

International Nuclear Information System (INIS)

Letourneau, E.G.; Wigle, D.T.

1980-01-01

A study was carried out to determine if lung cancer and general mortality rates in 13 Canadian cities were significantly correlated with average indoor radon daughter concentrations. The radon daughter measurements were obtained from a study of 10,000 homes chosen in a statistically valid grab sample basis. Cancer deaths by year of death, sex, age, and cause were retrieved for each of the cities for the period 1957-1976. Age specific and age standardized mortality rates were calculated. The results showed no evidence of any substantial association between general or lung cancer mortality rates and indoor radon daughter concentrations. The limitations of this study and the feasibility of a common international program of epidemiology of radon daughter exposure are discussed. A proposal is made for the use of case control studies of lung cancer to assess the relative importance of smoking, occupational and domestic exposure to radon daughters

[The mother's role in breasfeeding her primiparous daughter: "the togetherness"].

Science.gov (United States)

Machado, Ana Rita Marinho; Nakano, Ana Márcia Spanó; de Almeida, Ana Maria; Mamede, Marli Villela

2004-01-01

The authors' disquietudes are related to the structure for supporting women to breastfeed within their family environment. It is a qualitative study aiming at understanding the significance of breastfeeding among mothers and primiparous daughters, as well as identifying how the mother perceive herself as a means of support for her primiparous daughter and vice versa. The historic social construction of women for maternity has been used as a theoretical referential. The sample was made up of 10 women--five primiparous daughters and their mothers. The participation of the mother in her daughter's maternity was "to be along with her", sharing knowledge and life experiences.

Efficient measurement of radon daughters

International Nuclear Information System (INIS)

Rolle, R.

1992-01-01

In environmental control there is an increasing need for efficient measurement of radon and thoron daughters in air. Measuring instruments should be rugged and portable for field use, while also permitting unattended operation for several days. Simple operating procedures should permit evaluation of rapidly changing concentrations over extended periods. These requirements demand careful balance in the design of hardware and measuring procedures. The design principles for a continuous flow-through spectrometer, that has been developed for precision sequential measurement of radon and thoron daughters, are described. Because of the high precision of measurement, this type of instrument should find application in environments from technologically enhanced natural radiation to the very lowest natural background situations. (author)

Review of epidemiological studies on hazards of radon daughters

International Nuclear Information System (INIS)

Myers, D.K.; Stewart, C.G.; Johnson, J.R.

1981-01-01

A review, with nearly 100 references, of the biological effects of radon and radon daughters is presented. Calculations of the relative dose from daughter products, as well as of the variation in dose with such things as unattached fraction, particle size, age and breathing rate are discussed. Estimates of annual risk of lung cancer in miners after inhalation of thoron daughters are given, and compared with hazards of employment in various US industries. The implications of these epidemiological studies for future regulations are discussed

Daughter preference in Japan: A reflection on gender role attitudes?

Directory of Open Access Journals (Sweden)

Kana Fuse

2013-05-01

Full Text Available BACKGROUND Unlike other East Asian nations where preference for sons over daughters still prevails, gender preference for children in Japan has progressively shifted from son preference to a noticeable daughter preference over the past few decades. This emergence of daughter preference is surprising given that gender relations are more traditional in Japan than in other advanced countries. OBJECTIVE I focus on the extent to which individuals' gender preferences are shaped by their gender role attitudes and evaluate whether daughter preference is a reflection of convergence or a persistent divergence in gender roles in Japan. METHODS I use data from the Single Persons subset of the 11th Japanese National Fertility Survey conducted by the National Institute of Population and Social Security Research in 1997. Using multinomial logistic regression, I estimate the relationship between Japanese singles' gender role attitudes and their type of gender preference for children. RESULTS Findings suggest that the effect of gender role attitudes on one's child gender preference differs for men and women. Overall, while daughter preference is associated with nontraditional gender role attitudes for men, daughter preference is associated with traditional attitudes for women. CONCLUSIONS Traditionalism is still driving gender preference, though in a different way for men and women. Emerging daughter preference may not simply be a reflection of improvements in women's status, but in fact it is likely that persistent divergence in gender roles remain in Japan.

Scavenging of radon daughters by precipitation from the atmosphere

Energy Technology Data Exchange (ETDEWEB)

Fujinami, Naoto [Kyoto Prefectural Inst. of Hygienic and Environmental Sciences (Japan)

1997-02-01

By the continuous measurement of the radon daughters concentration in the rain and snow water and atmosphere and the data analysis, the following results were obtained. The radon daughters concentration was almost constant in the rain and snow water in spite of the length during weather without precipitation. It has not tendency to show the high concentration of radon daughters in precipitation and snow during beginning of them. When the precipitation intensity is constant, it`s concentration does not change during precipitation and snowfall. The concentration does not depend on the amount of precipitation, but on the precipitation intensity. We did not observe a correlation between the radon daughters concentration in the rain and snow water and that in the surface air. The atmospheric concentration was decreased by precipitation and snowfall, but that of rain and snow water did not decrease. The above results seems to show that the contribution of washout under the cloud to radon daughters in rain and snow water is small and that of rainout in the cloud is large. This result is agreement with the Jacob`s experimental results. (S.Y.)

'He supported me 100%': Mexican-immigrant fathers, daughters, and adolescent sexual health.

Science.gov (United States)

Coleman-Minahan, Kate; Samari, Goleen

2018-02-19

First and second generation Mexican-origin adolescents in the U.S. face social and economic disadvantage and sexual health disparities. Although fathers can support child and adolescent development, the literature has portrayed Mexican-origin immigrant fathers as emotionally distant and sexist. This study aims to treat migration as a social determinant of health to examine father-daughter relationships and adolescent sexual health in Mexican-origin immigrant families. Integrating qualitative data from life history interviews with 21 Mexican-origin young women in immigrant families with quantitative data on first and second generation Mexican-origin young women in the National Longitudinal Study of Adolescent to Adult Health, this study describes father-daughter relationships, examines the association between father-daughter relationships and daughters' early sexual initiation, and considers the impact of migration on the father-daughter relationship and sexual health among Mexican-origin young women. Qualitative data identify four types of father-daughter relationships: 'good,' hostile, distant, and conflicted. Supporting the qualitative patterns, quantitative data find that positive or 'good' father-daughter relationship quality is significantly associated with reduced risk of early sexual initiation. Importantly, father-daughter separation across borders and economic inequality facing immigrant families is associated with hostile or distant father-daughter relationship quality and increased risk of early sexual initiation. Reports of good father-daughter relationships are common and may protect against early sexual initiation in Mexican-origin immigrant families. Policies that keep families together and reduce economic inequality among immigrants may also reduce sexual health disparities among immigrant adolescents.

Intracellular trafficking of LET-756, a fibroblast growth factor of C. elegans, is controlled by a balance of export and nuclear signals

International Nuclear Information System (INIS)

Popovici, Cornel; Fallet, Mathieu; Marguet, Didier; Birnbaum, Daniel; Roubin, Regine

2006-01-01

The superfamily of fibroblast growth factors (FGF), which counts 22 members in humans, exerts many functions during animal development and adult life. LET-756 is one of the two FGFs of the nematode C. elegans. Re-introduction of LET-756 in a null mutant strain restores viability, allowing the study of structural requirements for LET-756 trafficking and function. LET-756 protein has several regions and motifs, including a non-classical internal motif required for secretion. We show here that a main difference in the wild-type LET-756 molecule and a truncated molecule that mimics a partial loss-of-function mutant lies on subnuclear expression. Using Cos-1 cells and rescue activity we show that: (i) nuclear localization is due to various redundant NLS, one of them acting as a nucleolar localization signal; (ii) nuclear LET-756 is addressed to the speckles by a stretch of glutamine residues; (iii) nuclear LET-756 is trafficking between speckles and nucleoli; (iv) in the nucleolus, LET-756 is associated with proteins of the rRNA splicing compartment; (v) changing LET-756 secretion signal prevents its nuclear localization. We propose that LET-756 exerts its functions through a balance between secreted and nuclear forms due to two opposite addressing signals (i) synergy of several NLS and (ii) attenuated secretion signal

Paternal smoking habits affect the reproductive life span of daughters.

Science.gov (United States)

Fukuda, Misao; Fukuda, Kiyomi; Shimizu, Takashi; Nobunaga, Miho; Andersen, Elisabeth Wreford; Byskov, Anne Grete; Andersen, Claus Yding

2011-06-30

The present study assessed whether the smoking habits of fathers around the time of conception affected the period in which daughters experienced menstrual cycles (i.e., the reproductive life span). The study revealed that the smoking habits of the farther shortened the daughters' reproductive life span compared with daughters whose fathers did not smoke. Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family

Directory of Open Access Journals (Sweden)

Ewelina Perdas

2016-06-01

Full Text Available Papillary thyroid carcinoma (PTC is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recently, let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. Circulating miRNA profiles of the let-7 family may be used as novel noninvasive diagnostic, prognostic, treatment and surveillance markers for PTC.

High-LET particle exposure of Skylab astronauts

International Nuclear Information System (INIS)

Benton, E.V.; Peterson, D.D.; Bailey, J.V.; Parnell, T.

1977-01-01

High-LET particle radiation was registered in nuclear track recording plastic dosimeters worn on the wrists of Skylab astronauts and located in a heavily shielded film vault. The mission-average planar flux of high-LET particles with LET >= 100 keV/micron . tissue has been determined to be 2.7 +- 0.6 particles/cm 2 . day . 2π sr and 0.34 +- 0.4 particles/cm 2 . day . 2π sr, respectively, for the nine astronauts and for the film vault. Comparison of results representative of a wide range of shielding depths reveals that the magnitude and slope of the integral LET spectrum of high-LET particles inside spacecraft are proportional to the amount of shielding. (author)

Ataxia telangiectasia: LET dependence of cellular inactivation

International Nuclear Information System (INIS)

Blakely, E.A.; Tobias, C.A.

1984-01-01

Human Ataxia telangiectasia cells (AT 2SF line) have been irradiated in vitro under aerobic and hypoxic conditions with heavy-ion beams accelerated at the Berkeley Bevalac as a part of a study to characterize the radiation responses of genetically sensitive and resistant cell lines to high LET radiations. Results from track-segment exposures to neon, silicon, argon and iron ion beams accelerated to initial energies of from 225 to 670 MeV/amu provided an LET range between 30 to 1,000 KeV/μm. The data indicate: (1) The sensitivity of AT cells increases with increasing LET, similar to resistant human lines (e.g., T-1 cells). However, due to efficient repair, T-1 cells are more resistant than AT cells at LET values below 200 keV/μm; (2) Maximum cell kill occurs for both lines at 100-200 keV/μm; at higher LET the sensitivity of the two lines approach each other; (3) There is only small variation in the sensitivity of AT cells to particles of various atomic numbers at the same LET; differences are more pronounced in the LET domain between 50 and 200 keV/μm; and (4) AT cells have slightly lower OER values than T-1 cells in the range of LET studied below 200 keV/μm

Calculated LET-Spectrum of Antiprotons

DEFF Research Database (Denmark)

Bassler, Niels

-LET components resulting from the annihilation. Though, the calculations of dose-averaged LET in the entry region may suggest that the RBE of antiprotons in the plateau region could significantly differ from unity. Materials and Methods Monte Carlo simulations using FLUKA were performed for calculating...

Workshop on dosimetry for radon and radon daughters

International Nuclear Information System (INIS)

Turner, J.E.; Holoway, C.F.; Loebl, A.S.

1978-05-01

Emphasis is placed on the dosimetry for radon and daughters, rather than on monitoring and instrumentation. The objectives of the meeting were to exchange scientific information, to identify problem areas in radon-daughter dosimetry, and to make any observations or recommendations by the participants through issuance of this report. The discussion topics included the history of dosimetry for radon and daughters, human data, aerosols, deposition and movement in the respiratory tract, dose calculations, dose-to-working-level-month (WLM) conversion factors, animal experiments, and the development of regulations and remedial criteria for reducing population exposures to radon daughters. This report contains a summary of Workshop discussions plus individual statements contributed by several of the participants. The outstanding problem areas from the standpoint of dosimetry appear to involve the appropriate lung organ mass to be used (average lung-tissue dose vs. high-level local dose); recognition of the discrete, rather than continuous, structure of the mucus; lack of knowledge about lung clearance; the variability of dose with the degree of disequilibrium and the unattached fraction of radon daughters for a given WLM; and questions about the character of uranium mine atmospheres actually breathed in the older mines from which much of the epidemiological information originates. The development of criteria for taking remedial action to reduce exposures involves additional concerns of basing long-term risk assessment on short-term sampling and applying WLM data for miners to general populations

The concept of average LET values determination

International Nuclear Information System (INIS)

Makarewicz, M.

1981-01-01

The concept of average LET (linear energy transfer) values determination, i.e. ordinary moments of LET in absorbed dose distribution vs. LET of ionizing radiation of any kind and any spectrum (even the unknown ones) has been presented. The method is based on measurement of ionization current with several values of voltage supplying an ionization chamber operating in conditions of columnar recombination of ions or ion recombination in clusters while the chamber is placed in the radiation field at the point of interest. By fitting a suitable algebraic expression to the measured current values one can obtain coefficients of the expression which can be interpreted as values of LET moments. One of the advantages of the method is its experimental and computational simplicity. It has been shown that for numerical estimation of certain effects dependent on LET of radiation it is not necessary to know the dose distribution but only a number of parameters of the distribution, i.e. the LET moments. (author)

Predicting radon/radon daughter concentrations in underground mines

International Nuclear Information System (INIS)

Leach, V.A.

1984-01-01

A detailed description of a computer programme is outlined for the calculation of radon/radon daughter concentrations in air. This computer model is used to predict the radon/radon daughter concentrations in Working Level (WL) at the workplace and at the various junctions at either end of the branches in a typical ventilation network proposed for the Jabiluka mine in the Northern Territory

Measurements of the deposition rates of radon daughters on indoor surfaces

International Nuclear Information System (INIS)

Wang, H.; Essling, M.A.; Toohey, R.E.; Rundo, J.

1982-01-01

The deposition rates of radon daughters on indoor surfaces have been measured by exposing the window of a proportional counter to the air of a house with high concentrations of radon and its daughters. Deposition velocities for unattached 218 Po (RaA) and 214 Pb (RaB) of approximately 4 mm sec - 1 were obtained by dividing the deposition rates by the concentrations of unattached daughters in the air. These results agree with those obtained by other workers but are dependent on the assumptions made about the fractions of the daughters which are attached to the atmospheric aerosol

Intergenerational abortion tendency between mothers and teenage daughters: a population-based cohort study.

Science.gov (United States)

Liu, Ning; Farrugia, M Michèle; Vigod, Simone N; Urquia, Marcelo L; Ray, Joel G

2018-01-29

A teenage woman's sexual health practices may be influenced by her mother's experience. We evaluated whether there is an intergenerational tendency for induced abortion between mothers and their teenage daughters. We conducted a retrospective population-based cohort study involving daughters born in Ontario between 1992 and 1999. We evaluated the daughters' data for induced abortions between age 12 years and their 20th birthday. We assessed each mother's history of induced abortion for the period from 4 years before her daughter's birth to 12 years after (i.e., when her daughter turned 12 years of age). We used Cox proportional hazard models to estimate a daughter's risk of having an induced abortion in relation to the mother's history of the same procedure. We adjusted hazard ratios (HRs) for maternal age and world region of origin, mental or physical health problems in the daughter, mother- daughter cohabitation, neighbourhood-level rate of teen induced abortion, rural or urban residence, and income quintile. A total of 431 623 daughters were included in the analysis. The cumulative probability of teen induced abortion was 10.1% (95% confidence interval [CI] 9.8%-10.4%) among daughters whose mother had an induced abortion, and 4.2% (95% CI 4.1%-4.3%) among daughters whose mother had no induced abortion, for an adjusted HR of 1.94 (95% CI 1.86-2.01). The adjusted HR of a teenaged daughter having an induced abortion in relation to number of maternal induced abortions was 1.77 (95% CI 1.69-1.85) with 1 maternal abortion, 2.04 (95% CI 1.91-2.18) with 2 maternal abortions, 2.39 (95% CI 2.19-2.62) with 3 maternal abortions and 2.54 (95% CI 2.33-2.77) with 4 or more maternal abortions, relative to none. We found that the risk of teen induced abortion was higher among daughters whose mother had had an induced abortion. Future research should explore the mechanisms for intergenerational induced abortion. © 2018 Joule Inc. or its licensors.

Exploration the Supportive Needs and Coping Behaviors of Daughter and Daughter in-Law Caregivers of Stroke Survivors, Shiraz-Iran: A Qualitative Content Analysis.

Science.gov (United States)

Gholamzadeh, Sakineh; Tengku Aizan, Hamid; Sharif, Farkhondeh; Hamidon, Basri; Rahimah, Ibrahim

2015-07-01

The period of hospital stay and the first month after discharge have been found to be the most problematic stages for family caregivers of stroke survivors. It is just at home that patients and caregivers actually understand the whole consequences of the stroke. The adult offspring often have more different needs and concerns than spousal caregivers. However, relatively little attention has been paid to the needs of this particular group of caregivers. Therefore, this qualitative content analysis study aimed to explore the supportive needs and coping behaviors of daughter and daughter in-law caregivers (DILs) of stroke survivors one month after the patient's discharge from the hospital in Shiraz, Southern of Iran. This is a qualitative content analysis study using semi-structured and in-depth interviews with a purposive sampling of seventeen daughter and daughter in-law caregivers. The data revealed seven major themes including information and training, financial support, home health care assistance need, self-care support need, adjusting with the cultural obligation in providing care for a parent in-law, and need for improving quality of hospital care. Also, data from the interview showed that daughter and daughter in-law caregivers mostly used emotional-oriented coping strategies, specially religiosity, to cope with their needs and problems in their care-giving role. The results of this qualitative study revealed that family caregivers have several unmet needs in their care-giving role. By providing individualized information and support, we can prepare these family caregivers to better cope with the home care needs of stroke survivors and regain control over aspects of life.

Teenage Daughters as a Cause of Divorce

OpenAIRE

Kabátek, Jan; Ribar, David C.

2017-01-01

Evidence from the U.S. that couples with daughters are more likely to divorce than couples with sons has not been found for other Western countries. Using 1995-2015 Dutch marriage registry data, we show that daughters are associated with higher divorce risks, but only when they are 13 to 18 years old. There are no detectable gender differences before or after those ages. These age-specific findings are at odds with son-preference and selection explanations for differences in divorce risks. In...

Overview of current radon and radon daughter research at LBL

International Nuclear Information System (INIS)

1983-01-01

This report provides a brief summary of radon and radon daughter research at Lawrence Berkeley Laboratory. The radon and radon daughter research program has two broad goals: (1) the study of sources of radon and its subsequent transport into houses, and (2) research on the behavior of radon daughters in indoor environments. Additional research effort is directed to several auxiliary areas, including development of instrumentation and monitoring techniques, studies of indoor air movement, and measurement and control of indoor particulate concentrations

Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc

Energy Technology Data Exchange (ETDEWEB)

Liu, Yongchao; Yin, Bingde; Zhang, Changcun; Zhou, Libin [Department of Urology, Shanghai First People' s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080 (China); Fan, Jie, E-mail: jief67@sina.com [Department of Urology, Shanghai First People' s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080 (China)

2012-01-06

Highlights: Black-Right-Pointing-Pointer This study is the first to test the let-7a/c-myc loop in renal cell carcinoma cell lines. Black-Right-Pointing-Pointer Let-7a down-regulated c-myc in three renal cell carcinoma cell lines. Black-Right-Pointing-Pointer c-myc target genes were down-regulated because of the let-7a-mediated down-regulation of c-myc. Black-Right-Pointing-Pointer The let-7a/c-myc loop has a significant function in renal cell carcinoma cell lines. -- Abstract: Widespread functions of the c-myc pathway play a crucial role in renal cell carcinoma (RCC) carcinogenesis. Thus, we evaluated the connection between proto-oncogenic c-myc and anti-neoplastic hsa-let-7a (let-7a) in RCC cell lines. The levels of c-myc and let-7a in 3 RCC cell lines (769P, Caki-1 and 786O) were measured after transfecting the cells with let-7a mimics or a negative control. The change in c-myc protein level was confirmed by Western blot. The anti-neoplastic function of let-7a was evaluated using cell counting kit-8 (CCK-8) for proliferation analysis and cell flow cytometry for cell cycle analysis. The changes of downstream targets of c-myc were measured using reverse transcription quantitative real-time PCR (qRT-PCR). Our results suggest for the first time that let-7a acts as a tumor suppressor in RCC cell lines by down-regulating c-myc and c-myc target genes such as proliferating cell nuclear antigen (PCNA), cyclin D1 (CCND1) and the miR17-92 cluster, which is accompanied by proliferation inhibition and cell cycle arrest.

Technical evaluation of a radon daughter continuous monitor in an underground uranium mine

International Nuclear Information System (INIS)

Bigu, J.; Grenier, M.

1982-07-01

An evaluation of a radon daughter monitor was carried out in an underground uranium mine. The monitor operates on continuous sampling and time integrating principles. Experimental and theoretical data were compared. Experimental results show that the monitor underestimates the Working Level, a fact which is partly attributed to plate-out of decay products in the monitor sampling head. However, a correction factor experimentally determined by standard calibration procedures can be programmed into the monitor to take into account losses by plate-out and other losses. Although the monitor was originally designed for radon daughters, it can equally be used in thoron daughter atmospheres and radon daughter/thoron daughter mixtures such as those encountered in some Canadian uranium mines. An analytical procedure is outlined to allow the calculation of Working Levels in radon daughter/thoron daughter atmospheres from the monitor α-count rate. The memory capability of the monitor should make it quite useful and flexible in underground and surface environments in the uranium mining industry

Communication strategies to reduce cancer disparities: Insights from African-American mother-daughter dyads.

Science.gov (United States)

Mosavel, Maghboeba; Wilson Genderson, Maureen; Ports, Katie A; Carlyle, Kellie E

2015-12-01

Mothers and daughters share a powerful and unique bond, which has potential for the dissemination of information on a variety of women's health issues, including the primary and secondary prevention of breast and cervical cancer. This study presents formative research from a long-term project examining the potential of mother-daughter communication in promoting cancer screening among African American women. Thirty-two mother-daughter pairs (N = 64) completed orally administered surveys regarding their cancer knowledge, beliefs and attitudes, and barriers to care. This study compares the attitudes and beliefs of low-income, urban, African American mothers and their adolescent daughters regarding cervical and breast cancer screening. Both mothers and daughters had fairly high levels of knowledge about breast and cervical cancer. In addition, there was a high concordance rate between mothers' and daughters' responses, suggesting a potential sharing of health knowledge between mother and daughter. These results have implications for selecting communication strategies to reduce health disparities, and support that the mother-daughter dyad could be a viable unit to disseminate targeted screening information. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

From rockstar researcher to selfless mentor: a daughter's perspective.

Science.gov (United States)

Castillo-Garsow, Melissa

2013-01-01

Carlos Castillo-Chavez's tenure at Cornell University with Simon Levine, also marks the beginning of my life as his daughter. I was nine months old when I arrived to Ithaca, and my recollections of my father in elementary school and middle school were of him furiously writing equations at his desk, or outside on the chalk board in our shed, or on napkins, notepads or anything he could get his hands on at restaurants; but more likely than not, away. When I was young, my father was becoming the researcher that today makes him a three-time Presidential honoree, a member of Barak Obama's Presidential Committee on the National Medal of Science, and of course, the purpose of this volume. Even in those early days, he was away a lot--either traveling to conferences or increasingly as an invited lecturer, or at the office. Of course, I was still (and am) a daddy's little girl, bonded forever by a shared obsession with the same movies (The Godfather, My Name is Nobody, The Man from Snowy River); the same TV shows (Law and Order); and all things sports related, but I also knew that my father was a very busy man and his time was limited. So I would watch him work, often with my own little extra homework he would give me to keep me entertained, peck him on the check and let him know that I would take over his job when I was old enough.

Let them eat cake!

OpenAIRE

Samson, Audrey; Gallardo, Francisco; FRAUD, -

2017-01-01

Let them eat cake!' is a food-led event serving an edible imaginary of a Facebook profile. In early 2012, Facebook conducted massive scale emotional contagion by manipulating the emotional expressions in the News Feeds of 689,003 users. This exemplifies how the governability and the biopolitics of everyday life flow through the many layers of shared images, liked videos, protocols, and hyperlinks, all orchestrated by the Facebook News Feed algorithm. 'Let them eat cake!' proposes a gustatory ...

77 FR 16566 - Submission for OMB Review, Comment Request, Proposed Collection: Let's Move Museums, Let's Move...

Science.gov (United States)

2012-03-21

..., Proposed Collection: Let's Move Museums, Let's Move Gardens AGENCY: Institute of Museum and Library..., comment request. SUMMARY: The Institute of Museum and Library Services announces that the following... functions of the agency, including whether the information will have practical utility; Evaluate the...

Attitude of Israeli mothers with vaccination of their daughters against human papilloma virus.

Science.gov (United States)

Ben Natan, Merav; Aharon, Osnat; Palickshvili, Sharon; Gurman, Vicky

2011-02-01

The purpose of the study is to examine whether the model based on the Theory of Reasoned Action (TRA) succeeds in predicting mothers' intention to vaccinate their daughters against the human papilloma virus infection. Questionnaires were distributed among convenience sample of 103 mothers of daughters 18 years and younger. Approximately 65% of mothers intend to vaccinate their daughters. Behavioral beliefs, normative beliefs, and level of knowledge had a significant positive effect on mothers' intention to vaccinate their daughters. High levels of religiosity were found to negatively affect mothers' intention to vaccinate their daughters. The TRA combined with level of knowledge and level of religiosity succeeds in predicting mothers' behavioral intentions regarding vaccinating daughters. This indicates the significance of nurses' roles in imparting information and increasing awareness among mothers. Copyright © 2011. Published by Elsevier Inc.

MicroRNA hsa-let-7b suppresses the odonto/osteogenic differentiation capacity of stem cells from apical papilla by targeting MMP1.

Science.gov (United States)

Wang, Yanqiu; Pang, Xiyao; Wu, Jintao; Jin, Lin; Yu, Yan; Gobin, Romila; Yu, Jinhua

2018-01-31

MicroRNA let-7 family acts as the key regulator of the differentiation of mesenchymal stem cells (MSCs). However, the influence of let-7b on biological characteristics of stem cells from apical papilla (SCAPs) is still controversial. In this study, the expression of hsa-let-7b was obviously downregulated during the osteogenic differentiation of SCAPs. SCAPs were then infected with hsa-let-7b or hsa-let-7b inhibitor lentiviruses. The proliferation ability was determined by CCK-8 and flow cytometry. The odonto/osteogenic differentiation capacity was analyzed by alkaline phosphatase (ALP) activity, alizarin red staining, Western blot assay, and real-time RT-PCR. Bioinformatics analysis was used to screen out the target of hsa-let-7b and the target relationship was confirmed by dual luciferase reporter assay. Hsa-let-7b was of no influence on the proliferation of SCAPs. Interferential expression of hsa-let-7b increased the ALP activity as well as the formation of calcified nodules of SCAPs. Moreover, the mRNA levels of osteoblastic markers (ALP, RUNX2, OSX, OPN, and OCN) were upregulated while the protein levels of DSPP, ALP, RUNX2, OSX, OPN, and OCN also increased considerably. Conversely, overexpression of hsa-let-7b inhibited the odonto/osteogenic differentiation capacity of SCAPs. Bioinformatics analysis revealed a putative binding site of hsa-let-7b in the matrix metalloproteinase 1 (MMP1) 3'-untranslated region (3'-UTR). Dual luciferase reporter assay confirmed that hsa-let-7b targets MMP1. The odonto/osteogenic differentiation ability of SCAPs ascended after repression of hsa-let-7b, which was then reversed after co-transfection with siMMP1. Together, hsa-let-7b can suppress the odonto/osteogenic differentiation capacity of SCAPs by targeting MMP1. © 2018 Wiley Periodicals, Inc.

Studies on the migration rule and mechanism of radon and its daughters

International Nuclear Information System (INIS)

Jia Wenyi; Fang Fang; Zhou Rongsheng; Ma Yingjie; Qiu Yuande; Hou Xinsheng; Wu Yunping; Zu Xiulan; Wang Xiaoqin

2000-01-01

By using very precise, highly sensitive, static accumulated, easily repeated CD-1 α-cup, the migration rule and mechanism of radon and its daughters was studied. Significant results were obtained: (1) Under laboratory conditions, the vertical component of migration of radon and its daughters was much greater than the horizontal component, the former was over 90% and the latter was less than 10%. (2) Despite the very big specific gravity of radon and its daughters, the descending component of migration was less than 45%, while the ascending component was more than 45%. (3) After α-particles (emitted from radon and its daughters) being slowed down. 4 He combined with the radon and its daughters to form clusters. When the density of the cluster was less than that of the air, the self-ascending would occur

Development and implementation of radon daughter measurement in Egypt

International Nuclear Information System (INIS)

Hussein, A.Z.; Mohamed, I.H.

2005-01-01

During the last decade, a programme was developed to study radon daughter risks and to carry out field and experimental measurements. The Egyptian Atomic Energy Authority lead the implementation of this programme in cooperation with the International Atomic Energy Agency through the coordination project EGY/9/020 and EGY/9/030. Several national authorities participated also in this study such as Nuclear Materials Corporation. This work involved the preparation and calibration of equipment, establishment of measuring techniques, survey in some cities and mines countrywide, and preparation of regulations for radiation safety of the workers who may be exposed to high levels of radon daughters. The study shows that there is no major environmental problem for the public due to exposure to radon daughter. Occupational problem may be probable in some underground mines with bad ventilation. Reported values for radon daughter levels in units of working level ranged from 0-0.26 in some buildings and ruins in the Egyptian cities and from 0-3 working level in underground phosphate and uranium mine in the Egyptian Eastern Desert

The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome

Science.gov (United States)

Loukil, Abdelhalim; Tormanen, Kati

2017-01-01

The two centrioles of the centrosome differ in age and function. Although the mother centriole mediates most centrosome-dependent processes, the role of the daughter remains poorly understood. A recent study has implicated the daughter centriole in centriole amplification in multiciliated cells, but its contribution to primary ciliogenesis is unclear. We found that manipulations that prevent daughter centriole formation or induce its separation from the mother abolish ciliogenesis. This defect was caused by stabilization of the negative ciliogenesis regulator CP110 and was corrected by CP110 depletion. CP110 dysregulation may be caused by effects on Neurl-4, a daughter centriole–associated ubiquitin ligase cofactor, which was required for ciliogenesis. Centrosome-targeted Neurl-4 was sufficient to restore ciliogenesis in cells with manipulated daughter centrioles. Interestingly, early during ciliogenesis, Neurl-4 transiently associated with the mother centriole in a process that required mother–daughter centriole proximity. Our data support a model in which the daughter centriole promotes ciliogenesis through Neurl-4–dependent regulation of CP110 levels at the mother centriole. PMID:28385950

Doses and affects of radon and its daughters

International Nuclear Information System (INIS)

Snihs, J.O.

1982-01-01

Radon and its short-lived daughters are one of the main contributors to the natural exposures of ionizing radiation to man. Their sources, levels and characteristics are described. By inhalation of radon and its daughters tissues in the lung are irritated by α-particles leading to an increased risk of lung cancer. Methods of calculation of doses and risks using the dosimetric approach and the epidemiological approach are described and discussed. (Author)

Like mother like daughter: putamen activation as a mechanism underlying intergenerational risk for depression.

Science.gov (United States)

Colich, Natalie L; Ho, Tiffany C; Ellwood-Lowe, Monica E; Foland-Ross, Lara C; Sacchet, Matthew D; LeMoult, Joelle L; Gotlib, Ian H

2017-09-01

Having a depressed mother is one of the strongest predictors for developing depression in adolescence. Given the role of aberrant reward processing in the onset and maintenance of depression, we examined the association between mothers' and their daughters' neural response to the anticipation of reward and loss. Fifteen non-depressed mothers with a history of recurrent depression and their never-disordered daughters, and 23 mothers without past or current depression and their never-disordered daughters, underwent functional magnetic resonance imaging while performing the monetary incentive delay task. To assess mother-daughter concordance, we first identified ROIs involved in the anticipation of reward and loss across all mother-daughter pairs. Within each of these ROIs, we examined the association between mothers' and daughters' neural response, and the interaction between group status and mothers' neural response in predicting daughters' neural response. We found a significant association between mothers' and daughters' putamen response to the anticipation of loss, regardless of mother's depression history. Furthermore, pubertal stage moderated the association between mother-daughter putamen concordance. Our findings suggest a unique role of the putamen in the maternal transmission of reward learning and have important implications for understanding disorders characterized by disturbances in reward learning and processing, such as major depression. © The Author (2017). Published by Oxford University Press.

Generation to generation: discrimination and harassment experiences of physician mothers and their physician daughters.

Science.gov (United States)

Shrier, Diane K; Zucker, Alyssa N; Mercurio, Andrea E; Landry, Laura J; Rich, Michael; Shrier, Lydia A

2007-01-01

To examine bias and sexual harassment experiences of physician mothers and their physician daughters; correlations of these experiences with career satisfaction, stress at work, stress at home, and percentage of women in specialty; and influences of the mother on her daughter's experiences. A convenience sample of 214 families with mother and daughter physicians was sent a 56-item survey that included questions on bias and sexual harassment experiences. Statistical comparisons were made within 136 dyads where both mother and daughter returned the questionnaire. Eighty-four percent of mothers and 87% of daughters responded. Mothers and daughters reported similarly high rates and severity of sexual harassment before medical school, while in residency/fellowship, while in practice/work setting, and by teachers and supervisors. Daughters reported higher rates of harassment during medical school and by patients, mothers by colleagues. Gender and racial/ethnic discrimination was lower for daughters compared with their mothers, but gender discrimination was still substantial. Compared with other daughters, daughters who experienced discrimination or sexual harassment reported lower career satisfaction and more stress at work and at home and worked in specialties with fewer women. Gender discrimination and sexual harassment remain entrenched in medical education and professional workplaces. Maternal role models and mentors were not as protective as anticipated. Leadership of medical institutions and professional associations must deal more effectively with persistent discrimination and harassment or risk the loss of future leaders.

Measurement of airborne concentrations of radon-220 daughter products by alpha-particle spectrometry

International Nuclear Information System (INIS)

Kerr, G.D.; Ryan, M.T.; Perdue, P.T.

1978-01-01

The decay of naturally occurring uranium-238 and thorium-232 produces radon-222 and radon-220 isotopes which can escape into the atmosphere. If these radon gases become concentrated in air, their daughter products may present an inhalation hazard to man. The airborne concentrations of radon-222 can usually be measured very accurately in the presence of normal airborne concentrations of radon-220 and its daughters. In contrast, the measurements of the airborne concentrations of radon-220 daughters are usually complicated by the presence of radon-222 and its daughters even at normally occurring airborne concentrations. The complications involved in these measurements can be overcome in most situations by using an alpha particle spectrometer to distinguish the activity of radon-222 daughters from that due to radon-220 daughters collected on a filter. A practical spectrometer for field measurements of alpha particle activity on a filter is discussed

LET effects on normal and radiosensitive cell lines

International Nuclear Information System (INIS)

Geard, C.R.; Travisano, M.

1986-01-01

Charged particles in the track segment mode were produced by the RARAF Van de Graaff accelerator and used to irradiate two CHO cell lines, a radiosensitive hypermutable line EM9 and its normal parent AA8. Asynchronous cells were irradiated attached to 6 micrometer thick Mylar with protons, deuterons and helium-3 particles at LETs ranging from 10 to 150 keV per micrometer. A 50 kVp x-ray tube integrated into the track segment facility provided a low LET comparison. Following irradiation cells were monitored for clonogenicity, and in a separate series of experiments frequencies of sister chromatid exchanges. Up to 9 experiments were carried out at each LET, with a total of 8 radiations of different LETs being compared. The optimally effective LET for cell survival was between 80 and 120 keV per micrometer, with the 150 keV per micrometer particles indicating energy wastage. The differential between the normal and radiosensitive cell lines was maintained at all LETs

Normal Pubertal Development in Daughters of Women With PCOS: A Controlled Study.

Science.gov (United States)

Legro, Richard S; Kunselman, Allen R; Stetter, Christy M; Gnatuk, Carol L; Estes, Stephanie J; Brindle, Eleanor; Vesper, Hubert W; Botelho, Julianne C; Lee, Peter A; Dodson, William C

2017-01-01

Daughters of women with polycystic ovary syndrome (PCOS) are thought to be at increased risk for developing stigmata of the syndrome, but the ontogeny during puberty is uncertain. We phenotyped daughters (n = 76) of mothers with PCOS and daughters (n = 80) from control mothers for reproductive and metabolic parameters characteristic of PCOS. We performed a matched case/control study at Penn State Hershey Medical Center that included non-Hispanic, white girls 4 to 17 years old. We obtained birth history, biometric, ovarian ultrasounds, whole-body dual-energy X-ray absorptiometry scan for body composition, 2-hour glucose challenged salivary insulin levels, and two timed urinary collections (12 hours overnight and 3 hours in the morning) for gonadotropins and sex steroids. We measured integrated urinary levels of adrenal (dehydroepiandrosterone sulfate) and ovarian [testosterone (TT)] steroids. Other endpoints included integrated salivary insulin levels and urinary luteinizing hormone levels. There were no differences in detection rates or mean levels for gonadotropins and sex steroids in timed urinary collections between PCOS daughters and control daughters, nor were there differences in integrated salivary insulin levels. Results showed that 69% of Tanner 4/5 PCOS daughters vs 31% of control daughters had hirsutism defined as a Ferriman-Gallwey score >8 (P = 0.04). There were no differences in body composition as determined by dual-energy X-ray absorptiometry between groups in the three major body contents (i.e., bone, lean body mass, and fat) or in ovarian volume between groups. Matched for pubertal stage, PCOS daughters have similar levels of urinary androgens and gonadotropins as well as glucose-challenged salivary insulin levels. Copyright © 2017 by the Endocrine Society

Depression impacts the physiological responsiveness of mother–daughter dyads during social interaction

Science.gov (United States)

Amole, Marlissa C.; Cyranowski, Jill M.; Wright, Aidan G. C.; Swartz, Holly A.

2017-01-01

Background Maternal depression is associated with increased risk of psychiatric illness in offspring. While risk may relate to depressed mothers' difficulties regulating emotions in the context of interacting with offspring, physiological indicators of emotion regulation have rarely been examined during mother–child interactions—and never among mother–adolescent dyads in which both mother and adolescent have histories of major depressive disorder (MDD). Methods We examined changes in high-frequency heart rate variability (HF-HRV), an indicator of parasympathetic (vagal) function that has been related to depression, stress, social engagement, and emotion regulation, in 46 mother–daughter dyads (23 in which both mother and daughter had an MDD history and 23 never-depressed controls). Hierarchical linear models evaluated changes in HF-HRV while mother–daughter dyads engaged in discussions about shared pleasant events and relationship conflicts. Results While control dyads displayed positive slopes (increases) in HF-HRV during both discussions, MDD dyads displayed minimal change in HF-HRV across discussions. Among controls, HF-HRV slopes were positively correlated between mothers and daughters during the pleasant events' discussion. In contrast, HF-HRV slopes were negatively correlated between MDD mothers and daughters during both discussions. Conclusions Vagal responses observed in control mother–daughter dyads suggest a pattern of physiological synchrony and reciprocal positive social engagement, which may play a role in adolescent development of secure social attachments and healthy emotion regulation. In contrast, MDD mothers and daughters displayed diminished and discordant patterns of vagal responsiveness. More research is needed to understand the development and consequences of these patterns of parasympathetic responses among depressed mother–daughter dyads. PMID:28060443

Depression impacts the physiological responsiveness of mother-daughter dyads during social interaction.

Science.gov (United States)

Amole, Marlissa C; Cyranowski, Jill M; Wright, Aidan G C; Swartz, Holly A

2017-02-01

Maternal depression is associated with increased risk of psychiatric illness in offspring. While risk may relate to depressed mothers' difficulties regulating emotions in the context of interacting with offspring, physiological indicators of emotion regulation have rarely been examined during mother-child interactions-and never among mother-adolescent dyads in which both mother and adolescent have histories of major depressive disorder (MDD). We examined changes in high-frequency heart rate variability (HF-HRV), an indicator of parasympathetic (vagal) function that has been related to depression, stress, social engagement, and emotion regulation, in 46 mother-daughter dyads (23 in which both mother and daughter had an MDD history and 23 never-depressed controls). Hierarchical linear models evaluated changes in HF-HRV while mother-daughter dyads engaged in discussions about shared pleasant events and relationship conflicts. While control dyads displayed positive slopes (increases) in HF-HRV during both discussions, MDD dyads displayed minimal change in HF-HRV across discussions. Among controls, HF-HRV slopes were positively correlated between mothers and daughters during the pleasant events' discussion. In contrast, HF-HRV slopes were negatively correlated between MDD mothers and daughters during both discussions. Vagal responses observed in control mother-daughter dyads suggest a pattern of physiological synchrony and reciprocal positive social engagement, which may play a role in adolescent development of secure social attachments and healthy emotion regulation. In contrast, MDD mothers and daughters displayed diminished and discordant patterns of vagal responsiveness. More research is needed to understand the development and consequences of these patterns of parasympathetic responses among depressed mother-daughter dyads. © 2016 Wiley Periodicals, Inc.

Size distribution of radon daughter particles in uranium mine atmospheres

International Nuclear Information System (INIS)

George, A.C.; Hinchliffe, L.; Sladowski, R.

1975-01-01

The size distribution of radon daughters was measured in several uranium mines using four compact diffusion batteries and a round jet cascade impactor. Simultaneously, measurements were made of uncombined fractions of radon daughters, radon concentration, working level, and particle concentration. The size distributions found for radon daughters were log normal. The activity median diameters ranged from 0.09 μm to 0.3 μm with a mean value of 0.17 μm. Geometric standard deviations were in the range from 1.3 to 4 with a mean value of 2.7. Uncombined fractions expressed in accordance with the ICRP definition ranged from 0.004 to 0.16 with a mean value of 0.04. The radon daughter sizes in these mines are greater than the sizes assumed by various authors in calculating respiratory tract dose. The disparity may reflect the widening use of diesel-powered equipment in large uranium mines. (U.S.)

Design criteria for a hemispherical detector for LET measurements

International Nuclear Information System (INIS)

Schell, M.C.; DeLuca, P.M. Jr.; Pearson, D.W.; Attix, F.H.

1980-01-01

A detector for the direct measurement of the Linear Energy Transfer (LET) in cylindrical geometry was developed by Brandan and DeLuca. The detector successfully measured the LET of protons and a fraction of the heavy charged particles generated in cylindrical A150 plastic and graphite walls by 14.8 MeV neutrons. In this report, we present design tests for the hemispherical LET detector which will measure the LET of charged particles in spherical geometry and allow comparison with calculated LET spectra. The hemispherical LET detector will also provide a data base for radiobiological predictions with the Track Structure Model by Katz. A comparison of predictions of radiobiological effects by the Theory of Dual Radiation Action and the Track Structure Model by Edwards and the authors indicate that the Track Structure Model predicts cell survival as a function of dose more accurately and hence an additional motivation for the present construction of the hemispherical LET detector

Internal causes of radon and its daughters upward migration and cluster phenomenon

International Nuclear Information System (INIS)

Jia Wenyi; Fang Fang; Zhou Rongsheng; Ma Yingjie; Qiu Yuande; Hou Xinsheng; Wu Yunping; Zu Xiulan; Wang Xiaoqin

1999-01-01

Radon and its daughters have a very big specific gravity. But under laboratory conditions, they have the ability to migrate upward. The phenomenon can't be interpreted by an external cause but by an internal cause. The mechanism is that radon and most of its daughters and parents are decaying bodies able to radiate α-particles. After deceleration, 4He can combine with radon and its daughters and parents to form clusters. When the buoyancy of air is greater than the gravity of the clusters, self-ascending occurs. Accordingly, the distance that Rn covered during 3.825 days (Rn half-life) should not be regarded as Rn and its daughters migrating distance, but should be calculated according to all effects. That clusters can be formed by 4He, Rn and its daughters are valuable to study because of the similarity between Rn and heavy metal particles

Mother-daughter dyadic approach for starting preconception counseling at puberty in girls with diabetes.

Science.gov (United States)

Charron-Prochownik, Denise; Fischl, Andrea Rodgers; Choi, Jessica; Schmitt, Patricia L; White, Neil H; Becker, Dorothy; Downs, Julie; Hannan, Margaret; Thurheimer, Jennifer; Sereika, Susan M

2014-12-29

Preconception counseling (PC) significantly and inexpensively reduces risks of reproductive-health complications for women with diabetes. Our validated technology-based preconception counseling intervention, READY-Girls , is tailored for female teens with type 1 (T1D) and type 2 (T2D) diabetes and targets decision-making regarding effective family planning and seeking PC. Our teen-focused research was instrumental in changing the American Diabetes Association's Practice Recommendations to specify that preconception counseling should "Start at puberty…". This directive requires support from well-informed mothers of teens. Our goal is to provide both teen girls and their mothers with preconception counseling knowledge, and provide mothers with sex-communication training. Evaluation should focus on mother-daughter dyads. This feasibility study explored mother's and daughter's awareness and knowledge of diabetes and pregnancy, and preconception counseling; and compared mother-daughter responses using dyadic analyses. A mixed-method design was conducted with 10 mothers of daughters with T1D. Mothers were given READY-Girls intervention and completed knowledge and support questionnaires. Their responses were compared to those of their daughter's who were participating in a large randomized, control intervention trial with READY-Girls . The major theme from one-on-one interviews was, "I know nothing about diabetes/pregnancy risks and PC". Mother's and daughter's perceptions of having limited knowledge were confirmed by low knowledge scores. Mothers perceived giving higher levels of support compared to their daughter's perceptions of receiving support. Mothers can play a vital role in initiating discussions regarding reproductive-health with their daughters and reinforcing preconception counseling. Mother-daughter team approach for starting preconception counseling at puberty in girls with diabetes is feasible. Mother-daughter dyadic analyses can be important to explore

Like mother, like daughter

Indian Academy of Sciences (India)

Lawrence

[See Box where she has reminisced about her ... Let me flash back in time and take a look at the family ... students and people working in related departments. We all .... appreciate these issues until much later when I faced gender based.

Latina Daughters' Childbearing Attitudes: The Role of Maternal Expectations and Education Communication

Science.gov (United States)

Mireles-Rios, Rebeca; Romo, Laura F.

2014-01-01

Adolescent girls' and their mothers' expectations for their daughters' college attainment, mother-daughter communication about education, and daughters' early childbearing attitudes were examined in 146 U.S.-raised Latina girls (mean age = 14.4 years) and their mostly immigrant mothers. Through structural equation modeling, we…

Latina Mother–Daughter Dyads: Relations Between Attachment and Sexual Behavior Under the Influence of Alcohol or Drugs

Science.gov (United States)

Dillon, Frank R.; Rojas, Patria; Schwartz, Seth J.; Duan, Rui

2009-01-01

Associations among mother-daughter attachment, mother and daughter substance abuse, and daughter’s sexual behavior under the influence of drugs and alcohol were investigated among 158 adult U.S. Latina daughters. Latina daughters were sampled from four mother–daughter dyad types: substance abusing mother and daughter, substance abusing mother only, substance abusing daughter only, and nonsubstance-abusing mother and daughter. Substance abusing daughters with substance abusing mothers, and daughters who were less strongly attached to their mothers, reported more sex under the influence of drugs. Age, marital status, substance abuse, and mother’s substance abuse all influenced the daughter’s sex under the influence of alcohol. An unexpected positive association between attachment and sex under the influence of alcohol was found for daughters who were more closely attached to a substance abusing mother. Implications for future research, and HIV/AIDS and drug prevention and treatment programs for Latinas are discussed. PMID:19399605

Radon daughter control in the Uravan Mineral Belt

International Nuclear Information System (INIS)

Swindle, R.W.

1977-01-01

The control of radon daughter products in mines of the Uravan Mineral Belt is strongly affected by the erratic nature of the ore deposits. Another problem is the frequent necessity of reactivating mine workings that have been inactive for many years. Ventilation holes and other airways are usually too small to provide adequate ventilation to satisfy current requirements, and they are often caved. The greatest change in ventilation systems in recent years has been the trend toward larger-diameter, drilled ventilation raises that provide more ventilation at considerably lower cost. The increase in raise size has aggrevated ground-support and ice-formation, difficulties, but these problems are being solved by lining the raises with shotcrete and grouting the water bearing horizons. Electronic air cleaners have been effectively used to remove radon daughter products from mine air for several years but their utility is limited by the rate of regrowth of the radon daughters after the air is cleaned. 5 figures

The Maternal Gift: Mothers' Investment in Their Daughters' Higher Education

Science.gov (United States)

Cooper, Linda

2017-01-01

This article explores the degree to which mothers participate in decisions surrounding their daughters' university choices in the English higher education sector, based on a gendered PhD study involving mother and adult daughter pairings in southern England. Examples are given of how extended middle-class mothering practices are enabling their…

LET calibration for CR-39 detectors in different oxygen environments

International Nuclear Information System (INIS)

Zhou, D.; Semones, E.; Weyland, M.; Benton, E.R.

2007-01-01

High LET (linear energy transfer) radiation is the main contributor to the radiation field in low Earth orbit (LEO) in terms of dose equivalent. CR-39 plastic nuclear track detectors (PNTDs) can measure the LET spectrum and charge spectrum for the complicated radiation field in space. Previous research indicated that the sensitivity of CR-39 is different for CR-39 PNTDs working in different oxygen environments. LET calibration for CR-39 detectors in different oxygen environments is needed. Almost all the previous LET calibration work was carried out for CR-39 detectors in good-oxygen condition, LET calibration work for CR-39 in poor-oxygen condition has not been conducted until our work. Systematic LET calibrations were carried out by JSC-SRAG (Space Radiation Analysis Group) for CR-39 detectors working in different oxygen environments and abundant results of LET calibrations were obtained. This paper introduces the method for CR-39 LET calibration, presents and discusses the calibration results and some applications

Mother-daughter communication about sex: the influence of authoritative parenting style.

Science.gov (United States)

Askelson, Natoshia M; Campo, Shelly; Smith, Sandi

2012-01-01

Parent-child communication about sex has been shown to delay sexual activity and increase contraceptive and condom use. The influence of authoritative parenting style and mothers' perception of daughters' risk on communication about sex was examined in this study. Mothers in a random sample (n=283) with daughters aged 9-15 years were mailed surveys asking about communication with their daughters regarding 11 sex-related topics. Multivariate linear regression was used to assess the influence of authoritative parenting style and mothers' perceptions of risk on the number of topics communicated about and age of the daughter at time of communication for a variety of sexual health communication topics. Authoritative parenting style was related to the number of topics communicated about and was a predictor of age of daughter at the time of communication about sexual intercourse, menstruation, dating/relationships, sexually transmitted diseases (STDs), HIV/AIDS, alcohol, contraceptives, and abstinence, while perceptions of risk were not significant influencers of age at the time of communication for any topics. This research points to the importance of parenting style in determining the timing of parent-child communication about sexual and other risk behaviors.

"Cloning Words": Euphemism, Neologism and Dysphemism as Literary Devices in Kazuo Ishiguro's "Never Let Me Go"

Science.gov (United States)

Pandey, Anjali

2011-01-01

This essay examines the theme and trope of "copies" in Kazuo Ishiguro's novel "Never Let Me Go." Whatever one's final reading of the novel, the theme and thread of copy, copies, copying and copied is never far off. In a semantic sense then, the act of "copying", both as a verb and the indexing of "copies" as…

[Adult mother-daughter relationships and psychological well-being: attachment to mothers, depressive symptoms, and self-esteem].

Science.gov (United States)

Kitamura, Kotomi

2008-06-01

This study examined how daughter's reported quality of their mother-daughter relationships during childhood and adulthood is related to their psychological well-being (depressive symptoms and self-esteem). A cross-sectional sample of 363 women, age 26 to 35 years, completed questionnaires. The association between the quality of daughters' relationships with their mothers and their psychological well-being depended on the daughters' marital and parental status. Regression estimates suggested that among single daughters and married daughters with children, childhood attachment dimensions (avoidance and anxiety) significantly contributed to psychological well-being, even after controlling for the effects of current closeness and excessive dependence. Current closeness, and excessive care seeking and care giving to their mother contributed to the psychological well-being of single daughters and married daughters without children, even after controlling for the effects of childhood attachment.

The role of long noncoding RNA-LET in cell proliferation and invasion of nasopharyngeal carcinoma and its mechanism

Directory of Open Access Journals (Sweden)

Chen L

2017-05-01

Full Text Available Lei Chen,1,* Lingling Sun,1,* Lei Dong,2 Peng Cui,3 Ziwei Xia,4 Chao Li,1 Yu Zhu5 1Department of Otolaryngology, The Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Pediatrics, Division of Hematology/Oncology, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA; 3Department of Multidisciplinary Consultation Center of TCM and Western Medicine, The Affiliated Qingdao Hiser Hospital of Qingdao University, Qingdao, 4Department of Clinical Medicine, The Second Clinical Medical School of Tianjin Medical University, 5Department of Clinical Laboratory, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration, Tianjin, People’s Republic of China *These authors contributed equally to this work Abstract: LncRNA-LET, a recently identified long noncoding RNA, has been shown to act as a tumor suppressor; however, its biological function and mechanism have not been fully investigated. Our research found that there was less expression of LET in nasopharyngeal carcinoma (NPC tissues than normal tissues and that LET might inhibit proliferation, adhesion and invasion of NPC in vitro by enhancing its expression. By contrast, decreased LET expression could promote the proliferation, adhesion and invasion of NPC. In addition, the expression profiles of related genes and MAPK/ERK pathway were also regulated effectively via overexpression or silencing of LET. This result provides comprehensive evidence of LET’s antitumor effect on NPC in vitro, which might provide a new approach for clinical treatment. Keywords: LncRNA-LET, proliferation, invasion, nasopharyngeal carcinoma, MAPK/ERK pathway

Application of single-chip microcomputer to portable radon and radon daughters monitor

International Nuclear Information System (INIS)

Meng Yecheng; Huang Zhanyun; She Chengye

1992-01-01

Application of single-chip microcomputer to portable radon and radon daughters monitor is introduced in this paper. With the single-chip microcomputer automation comes into effect in the process from sampling to measuring of radon and radon daughters. The concentrations of radon and radon daughters can be easily shown when the conversion coefficients are pre-settled before the measurement. Moreover, the principle and design are briefly discussed according to the characteristics of the monitor

Cell cycle phases in the unequal mother/daughter cell cycles of Saccharomyces cerevisiae.

Science.gov (United States)

Brewer, B J; Chlebowicz-Sledziewska, E; Fangman, W L

1984-11-01

During cell division in the yeast Saccharomyces cerevisiae mother cells produce buds (daughter cells) which are smaller and have longer cell cycles. We performed experiments to compare the lengths of cell cycle phases in mothers and daughters. As anticipated from earlier indirect observations, the longer cell cycle time of daughter cells is accounted for by a longer G1 interval. The S-phase and the G2-phase are of the same duration in mother and daughter cells. An analysis of five isogenic strains shows that cell cycle phase lengths are independent of cell ploidy and mating type.

Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET radiations

Data.gov (United States)

National Aeronautics and Space Administration — Ionizing radiations are categorized by linear energy transfer (LET) into low-LET and high-LET. High-LET is considered to have a higher relative biological...

The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development.

Science.gov (United States)

Lee, Sang In; Jeon, Mi-Hyang; Kim, Jeom Sun; Jeon, Ik-Soo; Byun, Sung June

2015-12-01

Early chick embryogenesis is governed by a complex mechanism involving transcriptional and post-transcriptional regulation, although how post-transcriptional processes influence the balance between pluripotency and differentiation during early chick development have not been previously investigated. Here, we characterized the microRNA (miRNA) signature associated with differentiation in the chick embryo, and found that as expression of the gga-let-7 family increases through early development, expression of their direct targets, TGFBR1 and LIN28B, decreases; indeed, gga-let-7a-5p and gga-let-7b miRNAs directly bind to TGFBR1 and LIN28B transcripts. Our data further indicate that TGFBR1 and LIN28B maintain pluripotency by regulating POUV, NANOG, and CRIPTO. Therefore, gga-let-7 miRNAs act as post-transcriptional regulators of differentiation in blastodermal cells by repressing the expression of the TGFBR1 and LIN28B, which intrinsically controls blastodermal cell differentiation in early chick development. © 2015 Wiley Periodicals, Inc.

Precise let-7 expression levels balance organ regeneration against tumor suppression

Science.gov (United States)

Wu, Linwei; Nguyen, Liem H; Zhou, Kejin; de Soysa, T Yvanka; Li, Lin; Miller, Jason B; Tian, Jianmin; Locker, Joseph; Zhang, Shuyuan; Shinoda, Gen; Seligson, Marc T; Zeitels, Lauren R; Acharya, Asha; Wang, Sam C; Mendell, Joshua T; He, Xiaoshun; Nishino, Jinsuke; Morrison, Sean J; Siegwart, Daniel J; Daley, George Q; Shyh-Chang, Ng; Zhu, Hao

2015-01-01

The in vivo roles for even the most intensely studied microRNAs remain poorly defined. Here, analysis of mouse models revealed that let-7, a large and ancient microRNA family, performs tumor suppressive roles at the expense of regeneration. Too little or too much let-7 resulted in compromised protection against cancer or tissue damage, respectively. Modest let-7 overexpression abrogated MYC-driven liver cancer by antagonizing multiple let-7 sensitive oncogenes. However, the same level of overexpression blocked liver regeneration, while let-7 deletion enhanced it, demonstrating that distinct let-7 levels can mediate desirable phenotypes. let-7 dependent regeneration phenotypes resulted from influences on the insulin-PI3K-mTOR pathway. We found that chronic high-dose let-7 overexpression caused liver damage and degeneration, paradoxically leading to tumorigenesis. These dose-dependent roles for let-7 in tissue repair and tumorigenesis rationalize the tight regulation of this microRNA in development, and have important implications for let-7 based therapeutics. DOI: http://dx.doi.org/10.7554/eLife.09431.001 PMID:26445246

Atmospheric radon daughters concentration inside and outside of cloud

International Nuclear Information System (INIS)

Nishikawa, Tsuguo; Okabe, Shigeru; Aoki, Masayoshi; Imamura, Takakazu; Iwata, Yoshitomo; Tamura, Yukihide; Tsuboguchi, Masayasu

1987-01-01

The measurements of the atmospheric radon daughters concentration in and out of the cloud were carried out on the top of the mountain, and in the upper air of the sea by using the airplane. The difference of the concentrations between inside and outside of the stratus measured on the top of the mountain was not clear. The atmospheric radon daughters concentration at the top of the mountain decreased when the amount of precipitation at that point was large. Concerning the cumulus investigated by using the airplane, the concentration in the cloud was a little higher than the concentration out of the cloud. Results of the measurements show that the cloud seems to be constructed of the various air masses whose radon daughters concentrations are different from each other even though it appears to be uniform. (author)

Let's do comprehension 5-6

CERN Document Server

Brodie, Andrew

2015-01-01

Let's Do Comprehension is a brand new series of six titles in the popular 'Let's Do' range. Each book contains a rich variety of stimulating reading passages, accompanied by questions of varying difficulty. Designed to be used at home, each book includes tips and clues from Alice the Alligator as well as extra challenges in Brodie's Brain Boosters. There is a clear answer section for reference by parents and children, together with bright, colourful reward stickers.

Let's do comprehension 8-9

CERN Document Server

Brodie, Andrew

2015-01-01

Let's Do Comprehension is a brand new series of six titles in the popular 'Let's Do' range. Each book contains a rich variety of stimulating reading passages, accompanied by questions of varying difficulty. Designed to be used at home, each book includes tips and clues from Alice the Alligator as well as extra challenges in Brodie's Brain Boosters. There is a clear answer section for reference by parents and children, together with bright, colourful reward stickers.

Biomedical applications of radionuclide generators with equal decay constants for parent and daughter

International Nuclear Information System (INIS)

Taylor, D.M.

1976-01-01

Reference is made to an article by Spencer and Hosain (Int. J. Appl. Radiat. Isotopes; 27:57 (1976)) on the theoretical aspects of radionuclide generator systems in which the parent and daughter nuclides have equal decay constants in which it was suggested that 'it would be possible to use an appropriate chemical compound of a parent and introduce it in a biological system to study the behaviour of the daughter element'. It is here pointed out that this suggestion assumes that in any biological system the daughter radionuclide produced by the decay of the parent nuclide in vivo will readily enter the general 'metabolic' pool of the daughter element. However studies are cited which have shown that virtually all the daughter radionuclide in many such systems remain within the skeleton and thus it is asserted that the assumption that a daughter radionuclide produced by the decay of a parent nuclide in vivo provides a true tracer for the behaviour of the daughter element is not generally valid, and considerable caution would have to be used in the interpretation of results obtained by this type of study. In a reply, the original authors say that the point made is germane but that the concept was well known to them and hence the use of the expression 'an appropriate chemical compound of a parent...' in their original paper. (U.K.)

Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.

Science.gov (United States)

Heo, Inha; Ha, Minju; Lim, Jaechul; Yoon, Mi-Jeong; Park, Jong-Eun; Kwon, S Chul; Chang, Hyeshik; Kim, V Narry

2012-10-26

RNase III Drosha initiates microRNA (miRNA) maturation by cleaving a primary miRNA transcript and releasing a pre-miRNA with a 2 nt 3' overhang. Dicer recognizes the 2 nt 3' overhang structure to selectively process pre-miRNAs. Here, we find that, unlike prototypic pre-miRNAs (group I), group II pre-miRNAs acquire a shorter (1 nt) 3' overhang from Drosha processing and therefore require a 3'-end mono-uridylation for Dicer processing. The majority of let-7 and miR-105 belong to group II. We identify TUT7/ZCCHC6, TUT4/ZCCHC11, and TUT2/PAPD4/GLD2 as the terminal uridylyl transferases responsible for pre-miRNA mono-uridylation. The TUTs act specifically on dsRNAs with a 1 nt 3' overhang, thereby creating a 2 nt 3' overhang. Depletion of TUTs reduces let-7 levels and disrupts let-7 function. Although the let-7 suppressor, Lin28, induces inhibitory oligo-uridylation in embryonic stem cells, mono-uridylation occurs in somatic cells lacking Lin28 to promote let-7 biogenesis. Our study reveals functional duality of uridylation and introduces TUT7/4/2 as components of the miRNA biogenesis pathway. Copyright © 2012 Elsevier Inc. All rights reserved.

Pri-let-7a-1 rs10739971 polymorphism is associated with gastric cancer prognosis and might affect mature let-7a expression

Directory of Open Access Journals (Sweden)

Li Y

2016-07-01

Full Text Available Ying Li, Qian Xu, Jingwei Liu, Caiyun He, Quan Yuan, Chengzhong Xing, Yuan Yuan Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University, Liaoning Provincial Education Department, Shenyang, People’s Republic of China Abstract: The relationship between the pri-let-7a-1 rs10739971 polymorphism and gastric cancer (GC risk has been reported. However, the role of this polymorphism in the prognosis of GC remains largely elusive. Sequenom MassARRAY platform method and the polymerase chain reaction (PCR-restriction fragment length polymorphism were used to investigate pri-let-7a-1 rs10739971 G→A in 334 GC patients. Real-time PCR detected expression of mature let-7a in serum and tissue. Patients with AA or GA+AA genotypes of the pri-let-7a-1 rs10739971 polymorphism demonstrated significantly longer survival time than those with the wild GG genotype. Stratified analysis indicated that survival time was significantly longer in women with AA or GA+AA genotypes and in Borrmann type I/II patients with GA heterozygote or GA+AA genotypes. AA genotype was more frequent in the lymphatic-metastasis-negative subgroup. Serum mature let-7a expression in healthy people with the GA heterozygote and the GA+AA genotype was higher than in those with the GG genotype, and the difference remained significant in the female healthy subgroup. Pri-let-7a-1 rs10739971 polymorphism might be a biomarker for GC prognosis, especially for female and Borrmann type I/II patients. The pri-let-7a-1 rs10739971 polymorphism might affect serum mature let-7a expression, and partly explain the mechanism of the relationship between the pri-let-7a-1 rs10739971 polymorphism and GC survival. Keywords: miRNA, let-7a, polymorphism, gastric cancer, prognosis, expression

The Lin28/let-7 axis regulates glucose metabolism

Science.gov (United States)

Zhu, Hao; Shyh-Chang, Ng; Segrè, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

2012-01-01

SUMMARY The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by blocking let-7 biogenesis. In studies of the Lin28/let-7 pathway, we discovered unexpected roles in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promoted an insulin-sensitized state that resisted high fat diet-induced diabetes, whereas muscle-specific loss of Lin28a and overexpression of let-7 resulted in insulin resistance and impaired glucose tolerance. These phenomena occurred in part through let-7-mediated repression of multiple components of the insulin-PI3K-mTOR pathway, including IGF1R, INSR, and IRS2. The mTOR inhibitor rapamycin abrogated the enhanced glucose uptake and insulin-sensitivity conferred by Lin28a in vitro and in vivo. In addition, we found that let-7 targets were enriched for genes that contain SNPs associated with type 2 diabetes and fasting glucose in human genome-wide association studies. These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism. PMID:21962509

Monitoring employee exposure to radon and its daughters in uranium mines

International Nuclear Information System (INIS)

Leach, V.A.; Lokan, K.H.

1979-06-01

Practical methods for measuring the concentration in air of radon and radon daughter are reviewed, and straightforward procedures are described for reliable field measurements. Typical field data, and sample calculations are provided, together with suitable procedures for calculating and reporting cumulative radon daughter exposures

Radon daughter exposure estimation and its relation to the exposure limit

International Nuclear Information System (INIS)

Stocker, H.

1981-10-01

Under current Atomic Energy Control Regulations, the annual limit for individual exposure to radon daughters is 4 WLM. The Regulations do not specify how the exposure is to be determined nor to what accuracy the measurements should be made. This paper discusses the historical and conventional grab-sampling and time-weighting methods for assigning exposures to radon daughters in uranium mines in Canada. As a further step in the evolution of exposure assignments, the system of personal radon daughter dosimetry is introduced as the more accurate means of assigning individual exposures and of adhering to the intent of the exposure limit

Hong Kong Chinese daughters' intergenerational caregiving obligations: a cultural model approach.

Science.gov (United States)

Holroyd, E

2001-11-01

This paper, based on a study carried out in Hong Kong, outlines the caregiving obligations of Hong Kong Chinese daughters towards their frail elderly parents. A cultural model approach drawn from cognitive anthropology is taken to focus on how Chinese caregiving daughters develop a sense of what is right and emotionally fulfilling and acquire the motivation to care for their parents. An ethnographic approach was used in the study and techniques included guided and open-ended interviews and non-participatory observations. A total of 20 co-residential caregiving daughters were interviewed in their homes on average twice over the course of one year. All interviews were conducted in Cantonese. Although the sample was small, daughters' accounts are structured by reference to cultural models and this structure provides the common basis for generalisability of results. Concepts of Confucian antecedents, reciprocity and personhood and other modern ideas of filial duty are explored. Conclusions are drawn about the shifting rights and obligations of Chinese caregiving daughters within the contemporary urban realities of Hong Kong. The findings of this study have relevance for the development of welfare policy for older Chinese persons and the chronically ill, and to all services involving women. The findings will also serve to inform family caregiver education programs.

Intergenerational abortion tendency between mothers and teenage daughters: a population-based cohort study

Science.gov (United States)

Liu, Ning; Farrugia, M. Michèle; Vigod, Simone N.; Urquia, Marcelo L.; Ray, Joel G.

2018-01-01

BACKGROUND: A teenage woman’s sexual health practices may be influenced by her mother’s experience. We evaluated whether there is an intergenerational tendency for induced abortion between mothers and their teenage daughters. METHODS: We conducted a retrospective population-based cohort study involving daughters born in Ontario between 1992 and 1999. We evaluated the daughters’ data for induced abortions between age 12 years and their 20th birthday. We assessed each mother’s history of induced abortion for the period from 4 years before her daughter’s birth to 12 years after (i.e., when her daughter turned 12 years of age). We used Cox proportional hazard models to estimate a daughter’s risk of having an induced abortion in relation to the mother’s history of the same procedure. We adjusted hazard ratios (HRs) for maternal age and world region of origin, mental or physical health problems in the daughter, mother– daughter cohabitation, neighbourhood-level rate of teen induced abortion, rural or urban residence, and income quintile. RESULTS: A total of 431 623 daughters were included in the analysis. The cumulative probability of teen induced abortion was 10.1% (95% confidence interval [CI] 9.8%–10.4%) among daughters whose mother had an induced abortion, and 4.2% (95% CI 4.1%–4.3%) among daughters whose mother had no induced abortion, for an adjusted HR of 1.94 (95% CI 1.86–2.01). The adjusted HR of a teenaged daughter having an induced abortion in relation to number of maternal induced abortions was 1.77 (95% CI 1.69–1.85) with 1 maternal abortion, 2.04 (95% CI 1.91–2.18) with 2 maternal abortions, 2.39 (95% CI 2.19–2.62) with 3 maternal abortions and 2.54 (95% CI 2.33–2.77) with 4 or more maternal abortions, relative to none. INTERPRETATION: We found that the risk of teen induced abortion was higher among daughters whose mother had had an induced abortion. Future research should explore the mechanisms for intergenerational induced

Influence of radon daughter exposure rate, unattachment fraction, and disequilibrium on occurrence of lung tumours

International Nuclear Information System (INIS)

Cross, F.T.; Palmer, R.F.; Dagle, G.E.; Busch, R.H.; Buschbom, R.L.

1984-01-01

Groups of male, specific-pathogen-free (SPF), Wistar rats were exposed to several concentrations of radon daughters and uranium ore dust to clarify the roles of exposure rate, unattached RaA daughters, and the degree of radon daughter disequilibrium, in the development of respiratory system disease. Modelled, human dosimetric data indicate that the dose to sensitive tissues of the respiratory tract increases with increasing radon daughter unattachment fraction and degree of disequilibrium. Data bearing on these developments as well as updated results of experiments designed to test the role of radon daughter exposure rate on lung tumour incidence are reported. (author)

Influence of random daughter exposure rate, unattachment fraction, and disequilibrium on occurrence of lung tumors

International Nuclear Information System (INIS)

Cross, F.T.; Palmer, R.F.; Dagle, G.E.; Busch, R.H.; Buschbom, R.L.

1983-10-01

Groups of male, specific-pathogen-free (SPF), Wistar rats were exposed to several concentrations of radon daughters and uranium ore dust to clarify the roles of exposure rate, unattached RaA daughters, and the degree of radon daughter disequilibrium, in the development of respiratory system disease. Modeled, human-dosimetric data indicate that the dose to sensitive tissues of the respiratory tract increases with increasing radon-daughter unattachment fraction and degree of disequilibrium. Experimental verification of these dose-effect relationships is needed to protect the health of workers and of the public exposed to radon-daughter environments. Data bearing on these relationships as well as updated results of experiments designed to test the role of radon-daughter exposure rate on lung-tumor incidence are reported. 13 references, 3 tables

Young Daughter Cladodes Affect CO2 Uptake by Mother Cladodes of Opuntia ficus-indica

Science.gov (United States)

PIMIENTA-BARRIOS, EULOGIO; ZAÑUDO-HERNANDEZ, JULIA; ROSAS-ESPINOZA, VERONICA C.; VALENZUELA-TAPIA, AMARANTA; NOBEL, PARK S.

2004-01-01

• Background and Aims Drought damages cultivated C3, C4 and CAM plants in the semi-arid lands of central Mexico. Drought damage to Opuntia is common when mother cladodes, planted during the dry spring season, develop young daughter cladodes that behave like C3 plants, with daytime stomatal opening and water loss. In contrast, wild Opuntia are less affected because daughter cladodes do not develop on them under extreme drought conditions. The main objective of this work is to evaluate the effects of the number of daughter cladodes on gas exchange parameters of mother cladodes of Opuntia ficus-indica exposed to varying soil water contents. • Methods Rates of net CO2 uptake, stomatal conductance, intercellular CO2 concentration, chlorophyll content and relative water content were measured in mature mother cladodes with a variable number of daughter cladodes growing in spring under dry and wet conditions. • Key Results Daily carbon gain by mother cladodes was reduced as the number of daughter cladodes increased to eight, especially during drought. This was accompanied by decreased mother cladode relative water content, suggesting movement of water from mother to daughter cladodes. CO2 assimilation was most affected in phase IV of CAM (late afternoon net CO2 uptake) by the combined effects of daughter cladodes and drought. Rainfall raised the soil water content, decreasing the effects of daughter cladodes on net CO2 uptake by mother cladodes. • Conclusions Daughter cladodes significantly hasten the effects of drought on mother cladodes by competition for the water supply and thus decrease daily carbon gain by mother cladodes, mainly by inhibiting phase IV of CAM. PMID:15567805

A radionuclide generator for the production of 211Pb and its daughters

International Nuclear Information System (INIS)

Atcher, R.W.; Friedman, A.M.; Huizenga, J.R.

1989-01-01

211 Pb and its daughters are produced in a generator system which utilizes the distillation of the intermediate daughter 219 Rn from 223 Ra. The radium is precipitated as the stearate to isolate the parent while allowing the gaseous daughter to emanate. While the yield of the system is low, approximately 10%, the radionuclidic purity is extremely high. No measurable 223 Ra is found in the product. 223 Ra is separated from its parent, 227 Ac, by cation exchange. (author) 7 refs

Blood-letting in anorexia nervosa: a case study.

Science.gov (United States)

Morgan, J F; Lacey, J H

2000-05-01

Deliberate blood-letting has been characterized as an alternative to purging behavior in bulimia. We describe a female healthcare worker with an 8-year history of restrictive anorexia nervosa, who initially presented with anemia, using blood-letting, cold baths, and starvation to control her mental state. In contrast with the previous cases of bulimia, the aim of blood-letting in this case of anorexia nervosa was to achieve anemia. She compared the psychic correlates of anemia to emaciation, rather than to deliberate self-harm or purging. We note that mainstream 19th century psychiatry prescribed "baths, blood-letting and diet" as a treatment of "madness." Copyright 2000 by John Wiley & Sons, Inc.

Lung cancer mortality among nonsmoking uranium miners exposed to radon daughters

International Nuclear Information System (INIS)

Roscoe, R.J.; Steenland, K.; Halperin, W.E.; Beaumont, J.J.; Waxweiler, R.J.

1989-01-01

Radon daughters, both in the workplace and in the household, are a continuing cause for concern because of the well-documented association between exposure to radon daughters and lung cancer. To estimate the risk of lung cancer mortality among nonsmokers exposed to varying levels of radon daughters, 516 white men who never smoked cigarettes, pipes, or cigars were selected from the US Public Health Service cohort of Colorado Plateau uranium miners and followed up from 1950 through 1984. Age-specific mortality rates for nonsmokers from a study of US veterans were used for comparison. Fourteen deaths from lung cancer were observed among the nonsmoking miners, while 1.1 deaths were expected, yielding a standardized mortality ratio of 12.7 with 95% confidence limits of 8.0 and 20.1. These results confirm that exposure to radon daughters in the absence of cigarette smoking is a potent carcinogen that should be strictly controlled

Lung cancer mortality among nonsmoking uranium miners exposed to radon daughters

International Nuclear Information System (INIS)

Roscoe, R.J.; Stenland, K.; Halperin, W.E.; Waxweiler, R.J.

1990-01-01

This paper reports on radon daughters, both in the workplace and in the household, that are a continuing cause of concern because of the well-documented association between exposure to radon daughters and lung cancer. To estimate the risk of lung cancer mortality among nonsmokers exposed to varying levels of radon daughters, 516 white men who never smoked cigarettes, pipes, or cigars were selected from the U.S. Public Health Service cohort of Colorado Plateau uranium miners and followed up from 1950 through 1984. Age-specific mortality rates for nonsmokers from a study of U.S. veterans were used for comparison. Fourteen deaths from lung cancer were observed among the nonsmoking miners, while 1.1 deaths were expected, yielding a standardized mortality radio of 12.7 with 95% confidence limits of 8.0 and 20.1. These results confirm that exposure to radon daughters in the absence of cigarette smoking is a potent carcinogen that should be strictly controlled

Time sequence determination of parent–daughter radionuclides using gamma-spectrometry

Energy Technology Data Exchange (ETDEWEB)

Burnett, J. L.; Britton, R. E.; Abrecht, D. G.; Davies, A. V.

2017-05-06

The acquisition of time-stamped list (TLIST) data provides additional information useful to gamma-spectrometry analysis. A novel technique is described that uses non-linear least-squares fitting and the Levenberg-Marquardt algorithm to simultaneously determine parent-daughter atoms from time sequence measurements of only the daughter radionuclide. This has been demonstrated for the radioactive decay of short-lived radon progeny (214Pb/214Bi, 212Pb/212Bi) described using the Bateman first-order differential equation. The calculated atoms are in excellent agreement with measured atoms, with a difference of 1.3 – 4.8% for parent atoms and 2.4% - 10.4% for daughter atoms. Measurements are also reported with reduced uncertainty. The technique has potential to redefine gamma-spectrometry analysis.

The Lin28/let-7 Axis Regulates Glucose Metabolism

NARCIS (Netherlands)

Zhu, Hao; Shyh-Chang, Ng; Segre, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G.; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

2011-01-01

The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating-metabolism. When overexpressed in mice, both

Letting die: A moral defence | Adenugba | Sophia: An African ...

African Journals Online (AJOL)

This paper draws a distinction between letting die and active euthanasia. It argues that there is a moral difference between letting die and active euthanasia which strictly intends to cause death. The difference between letting die and active euthanasia lies in intention though intention in both cases can be said to be ...

Compact detector for radon and radon daughter products

International Nuclear Information System (INIS)

Alter, H.W.; Oswald, R.A.

1986-01-01

This invention provides an improved compact track registration detector for radon gas. The detector comprises a housing having an open mouth, a bottom, and side walls; track registration means, supported inside the housing, which forms damage tracks along paths traversed by alpha particles; a microporous filter positioned across the mouth of the housing to prevent entry of radon daughters and particulate matter; and a cap that may be placed on the mouth of the housing to retain the filter. The housing has internal wall surfaces dimensioned to optimize the registration of alpha particles from radon and radon daughters present in the housing

Are daughters' childbearing intentions related to their mothers' socio-economic status?

Directory of Open Access Journals (Sweden)

Maria Rita Testa

2016-09-01

Full Text Available Background: Unlike actual fertility, fertility intentions are often found to be positively correlated with education. The literature explaining this paradox is scarce. Objective: We aim to fill the gap in the existing scientific literature by searching for the main factors that influence highly educated women to plan a larger family size. Methods: Using the first wave of the Generations and Gender Survey for four countries (Austria, Bulgaria, Italy, and Norway, we analyse the relationship between mother's socio-economic status and daughter's fertility intentions, controlling for daughter's socio-economic status and sibship size. Zero-inflated Poisson regression models are employed to estimate the predictors of women's additionally intended number of children. Results: We find that the effect of family of origin is exerted mainly through sibship size among childless daughters: Daughters with more siblings intend to have more children. After the transition to parenthood, the effect of family of origin is exerted mainly through the mother's level of education: Daughters with highly educated mothers intend to have more children. Conclusions: The empirical results suggest that the positive link between births intentions and level of education might not merely be an artefact generated by the design of cross-sectional surveys but the outcome of a better socio-economic status that allows forming positive reproductive plans. Contribution: The positive role of mother's socio-economic status on daughter's fertility decision-making offers a valuable interpretation of the positive link between education and fertility intentions which goes beyond the alternative explanations referring to self-selection, partner effect, or time squeeze, and needs to be confirmed by further research.

Evaluation of experiences in long-term radon and radon-daughter measurements

International Nuclear Information System (INIS)

Young, J.A.; Jackson, P.O.; Thomas, V.W.

1982-12-01

Pacific Northwest Laboratory (PNL) is performing side-by-side measurements of radon and radon daughter concentrations using several instruments and techniques, and is comparing these measurements with side-by-side measurements made by other investigators at other locations. The standard deviation of the differences between the (natural) logarithms of the Terradex Track Etch radon concentrations and the logarithms of the Radon Progency Integrating Sampling Units (RPISU) radon daughter concentrations (S.D.-ln) measured in 50 buildings in Edgemont, South Dakota, was 0.37. Using this S.D.-ln, it can be calculated that if the Track Etch radon daughter concentration is 0.010 WL there should be only a 14% probability that the RPISU average would be greater than 0.015 WL, and only a 3% probability tht the RPISU average would be greater than 0.020 WL. If buildings had been cleared from remedial action when the Track Etch averages were less than 0.10 WL, then about 61% of the buildings would have been cleared from remedial action, and only a few percent of these buildings would have actually had average RPISU concentrations greater than 0.015 WL. The S.D.-ln between the Track Etch radon measurements and the RPISU radon daughter measurements made by ALARA at Grand Junction, the PERM radon measurements and the MOD-225 radon daughter measurements made by Mound Facility at Canonsburg and Middlesex, and the PERM and Track Etch radon measurements made by Mound Facility at Salt Lake City were similar to the S.D.-ln between the Track Etch radon measurements and the RPISU radon daughter measurements at Edgemont

Factors affecting daughters distribution among progeny testing Holstein bulls

Directory of Open Access Journals (Sweden)

Martino Cassandro

2012-01-01

Full Text Available The aim of this study was to investigate factors influencing the number of daughters of Holstein bulls during the progeny testing using data provided by the Italian Holstein Friesian Cattle Breeders Association. The hypothesis is that there are no differences among artificial insemination studs (AIS on the daughters distribution among progeny testing bulls. For each bull and beginning from 21 months of age, the distribution of daughters over the progeny testing period was calculated. Data were available on 1973 bulls born between 1986 and 2004, progeny tested in Italy and with at least 4 paternal half-sibs. On average, bulls exited the genetic centre at 11.3±1.1 months and reached their first official genetic proof at 58.0±3.1 months of age. An analysis of variance was performed on the cumulative frequency of daughters at 24, 36, 48, and 60 months. The generalized linear model included the fixed effects of year of birth of the bull (18 levels, artificial insemination stud (4 levels and sire of bull (137 levels. All effects significantly affected the variability of studied traits. Artificial insemination stud was the most important source of variation, followed by year of birth and sire of bull. Significant differences among AI studs exist, probably reflecting different strategies adopted during progeny testing.

Emanation of 232U and its radioactive daughter products from respirable size particles

International Nuclear Information System (INIS)

Cuddihy, R.G.; Griffith, W.C.; Hoover, M.D.; Kanapilly, G.M.; Stalnaker, N.D.

1978-01-01

This study is to develop a model for the emanation of 232 U and its radioactive daughter products from particles of Th-U fuel material. The radiation doses to internal organs following inhalation of these particles can only be calculated by knowing the rate of emanation of the daughters from particles in the lung and the subsequent excretion or translocation of the daughters to other organs. The emanation mechanisms are recoil of the daughter nuclei from the particle during alpha decay of the parent, diffusion of inert gas daughters from the particle and dissolution of the particle itself in biological fluids. Experiments to evaluate these mechanisms will involve ThO 2 and UO 2 particles in the size range 0.1 to 1.0 μm MMAD uniformly labeled with 232 U. The influence of the material temperature history on emanation will be investigated by heat treating particles at 600 and 1400 0 C

Mother - Daughter Relationship’s links to Daughter’s Self-Esteem and Life Satisfaction

OpenAIRE

ONAYLI, Selin; ERDUR-BAKER, Özgür

2013-01-01

This study examines the relation of mother - daughter relationship to an adult daughter’s self- esteem and life satisfaction. 426 university students with a mean age of 21.62 (SD= 2.35) participated in the study. Adult Mother - Daughter Questionnaire, the Rosenberg Self-Esteem Scale and the Satisfaction with Life Scale were administered. The canonical correlation analysis revealed that three indicators of mother - daughter relationship (connectedness, interdependency, and trust in hierarchy) ...

Biological basis of inhalation exposure of radon and its daughters

International Nuclear Information System (INIS)

Matsuoka, Osamu

1989-01-01

Since inhalation exposure by radon and its daughters is very specific type of internal exposure, it is necessary to understand its characteristic nature. The specificity originates from the nuclear feature of radon daughters and the biological micro-environment in the respiratory tract. Inhaled radon and its daughters exist in the respiratory tract as ions attached to air dusts and deposit on the mucus surface of the respiratory tract by various mechanisms such as impaction, sedimentation and diffusion. Deposition of radon daughters is predominant around the site of the fourth generation according to Weibel's model. Deposited particles with radon daughters are cleared by muco-ciliary transportation. Its speed is estimated to be about 1.0 cm/min, at the upper region. Alpha decay will happen during transportation in the respiratory tract. Radon has no tissue affinity metabolically. Therefore, the irradiation is limited to the epithelial cells of respiratory tract. The cell components within 30-70 micron in depth are irradiated with alpha particle. Biological effectiveness of alpha radiation is very high compared with beta or gamma radiation. The target cell for carcinogenesis by radon exposure is considered to be the basal cell of epithelium. Lung cancer induced by radon inhalation is recognized to be squamous cell carcinoma, small cell carcinoma, or oat-cell carcinoma and adenocarcinoma. The modification factors which influence the effect of radon exposure are co-inhalation of ore dust and smoking habit. According to epidemiological studies on lung cancer which occurred in uranium miners, it is suggested that the smoking habit strongly promotes lung cancer induction. (author)

The dependence of relative biological effectiveness from LET

International Nuclear Information System (INIS)

Savich, A.V.

1985-01-01

A dependence of radiation-chemical yields of DNA injuries on the LET value is found for two transformations - one and two-strand breaks of it. It is shown that the yield of one-strand breaks decreases with the increase of LET value, and the quantity of two-strand breaks at first increases reaching the maximum value within the LET range from 100 up to 150 eV/nm and then decreases. The considered semiempiric theories of the RBE dependences on LET permits using the experimentally determined parameters characterizing radiosensitivity, to estimate the efficiency of the effect of ionizing radiation on cells at different doses, types of radiation and levels of saturation with oxygen. The stage of the cell cycle is also taken into account

Health hazards from radon daughters in dwellings in Sweden

International Nuclear Information System (INIS)

Axelson, O.; Edling, C.

1980-01-01

To clarify the possible etiological role for lung cancer from exposure to the low levels of radon and its daughters in dwellings, a case-control study was made, comparing cases of lung cancer with controls with respect to residency in different types of houses. This pilot study was restricted to include only people who lived in typically rural areas. The results support the hypothesis that radon and radon daughter exposure in dwellings is pertinent to the question of the etiology of lung cancer

Optimizing measurement sensitivity to facilitate monitoring environmental levels of Rn-daughter concentrations

International Nuclear Information System (INIS)

Keefe, D.J.; McDowell, W.P.; Groer, P.G.; Witek, R.T.

1977-01-01

In the measurement of environmental levels of radioactivity, the primary problem is the accumulation of a statistically meaningful number of counts within a reasonable period of time. In the case of measurements of airborne 222 Rn-daughter concentrations, the problem is further complicated by the particularly short half-life, 3.05 minutes, of RaA (Po 218 ). Since the Rn-daughters, (RaA, RaB [Pb 214 ] and RaC [Bi 214 ]) are of interest, the equations interrelating these Rn-daughter concentrations were derived from the laws of radioactive-series decay. These equations, although straightforward, are cumbersome to solve. To facilitate the efficient use of these equations, a computer program has been written which permits the calculation of Rn-daughter concentrations or expected counts for a given set of measurement parameters (flow rate and detector efficiencies). A subroutine then calculates the optimum pumping and counting times required to provide the number of counts necessary for acceptable statistics at environmental levels of 222 Rn-daughter concentrations. This subroutine contains a set of parameters, flow rate and efficiencies, that are fixed using realistic restrictions. The use of these optimized pumping and counting times results in maximum measurement sensitivity under realistic constraints

Radon and its daughters in vivo

Energy Technology Data Exchange (ETDEWEB)

Rundo, J

1984-05-01

Prolonged exposure to radon should build up a reservoir of radon in body fat and fluids. Movement of the subject to an environment with a lower radon concentration from an environment with a higher level of radon would result in an exhalation of radon, and the initial exhalation rate of radon should depend on the radon concentration inhaled. This paper describes the behavior of radon and its daughters in vivo and a relationship between the radon exhalation rate and the time after a meal. A major but short-lived postprandial increase in the exhalation rate of radon was observed. We report a similar effect in the exhalation rate of radon by persons containing no radium. It should be noted that the possibility exists that a large amount of radon daughters in the chest may interfere in the investigation of possible internal contamination with plutonium or other actinides by external counting. (author).

Radon daughter plate-out onto Teflon

Science.gov (United States)

Morrison, E. S.; Frels, T.; Miller, E. H.; Schnee, R. W.; Street, J.

2018-01-01

Radiopure materials for detector components in rare event searches may be contaminated after manufacturing with long-lived 210Pb produced by the decay of atmospheric radon. Charged radon daughters deposited on the surface or implanted in the bulk of detector materials have the potential to cause noticeable backgrounds within dark matter regions of interest. Understanding the mechanics governing these background signals is therefore a paramount concern in dark matter experiments in order to distinguish a real signal from internal detector backgrounds. Teflon (i.e. PTFE) is a specific material of interest because it makes up the walls of the inner detector of many liquid noble detectors such as the LUX-ZEPLIN experiment. The rate of radon daughter plate-out onto Teflon can be orders of magnitude larger than the plate-out rate onto other materials. Mitigation of plate-out onto Teflon and steel by proximity to other materials is demonstrated.

Domestic and personal determinants of the contamination of individuals by household radon daughters

International Nuclear Information System (INIS)

Stebbings, J.H.; Kardatzke, D.R.; Toohey, R.E.; Essling, M.E.; Pagnamenta, A.

1986-01-01

Radon daughters were counted by gamma spectroscopy from 180 adult residents of eastern Pennsylvania during the winter of 1983-84. Body radon daughter contamination is an index of relative individual respiratory exposures to radon daughters. These can be related to household radon levels, and to personal risk factors such as sex and tobacco smoking. Over 75% of this Pennsylvania population appeared to have environmentally enhanced radon daughter contamination; 59% had counting rates greater than 2 s.d. above background. House radon levels were the major determinants of radon daughters contamination in the 112 subjects for which both sets of measurements were available (p<.001). Both sex (<.02) and cigarette smoking (p<.005) were found to significantly modify that relationship, after nonlinear adjustment for travel times. Using a logarithmic model, for a given radon level body contamination by radon daughters in females was 2-3.5x higher than in males. Nonsmokers had 2-4x higher levels of contamination than smokers. For female nonsmokers relative to male smokers (which in general corresponds to the population of major concern relative to the population from which risk estimates have been derived), the excesses multiply. These results are for total contamination, both internal and external

Parent-daughter equilibria in ocean arising out of disposal of solid radioactive wastes on the sea bed

International Nuclear Information System (INIS)

Sarma, T.P.; Krishnamoorthy, T.M.

1986-01-01

One dimension diffusion model, incorporating geochemical elimination and reflection at ocean boundaries, is employed to show the differences in spatial and temporal distribution of parent and daughter radionuclides, produced in situ, due to the discharge of solid radioactive wastes on to the sea bed. Concentration of daughter is generally lower than that of parent in deep waters. Short-lived daughters (relative to parent) reach spatial equilibrium with parent for finite periods whereas long-lived daughters attain only a fraction of the parent activity. However, when the dumping operation is assumed to be for infinite period, the relative ratio of concentration of daughter to parent would reach value > 1 in surface waters irrespective of the half-lives of the daughter and the magnitude of this ratio increases with increase in half-life of the daughter relative to the parent. This is the result of steep vertical gradient for the parent due to the small physical half-life and more or less uniform concentration of long-lived daughter. Geochemical elimination rate, when becomes significant in the overall removal processes, controls this differential spatial gradient of daughter and parent. However, the integrated activity of daughter over the entire depth is equal to or less than the parent activity. (author)

Let G be a group

DEFF Research Database (Denmark)

Lützen, Jesper

2015-01-01

I moderne formalistisk matematik er ontologi blevet erstattet med spørgsmålet om konsistens af et aksiomatisk system. I artiklen gøres der rede for hvordan denne opfattelse er blevet til og denne historie opfattes i sig selv som en slags erstatning for ontologi......I moderne formalistisk matematik er ontologi blevet erstattet med spørgsmålet om konsistens af et aksiomatisk system. I artiklen gøres der rede for hvordan denne opfattelse er blevet til og denne historie opfattes i sig selv som en slags erstatning for ontologi...

An exploratory study of mother-daughter physicians: an intergenerational comparison of professional and personal experiences.

Science.gov (United States)

Shrier, Diane K; Shrier, Lydia A

2005-12-01

Physician daughters of physician mothers may experience unique advantages in their career development and in combining career and family. The objective of this exploratory study, the first on mother-daughter physicians, was to compare the professional and personal characteristics of physician mothers and their physician daughters. Two hundred fourteen families with at least one mother-daughter physician pair were identified through a nationwide search; 84% of the mothers and 87% of the daughters contacted returned a 56-item questionnaire. Data were analyzed to compare professional and personal characteristics of the subset of mothers and daughters who had both responded (n = 136 pairs). Compared to their physician mothers, physician daughters were less satisfied with their career, less likely to feel in control of their work environment, more likely to report moderate or severe daily stress at work, and less likely to want their children to become physicians or to want to become physicians again if they were to relieve their lives. They were also less likely to want to change specialties. Physician daughters were more likely than their physician mothers to be 30 years or older when they had their first child, to have taken parental leave, and to have a spouse who took parental leave and less likely to experience their caregiving as a hindrance to their professional work and advancement. Despite the availability of a physician mother role model, physician daughters reported less career satisfaction and more work-related stress than their physician mothers. These findings warrant further exploration and support the need for new work-family paradigms in medicine.

Some problems of parametric neutron activation analysis based on the use of radioactive daughters of longer-lived mothers with low mother/daughter half-life ratios

International Nuclear Information System (INIS)

Cohen, I.M.

2012-01-01

The theoretical and practical aspects of the use of radioactive daughters originated from the decay of longer-lived radioactive mothers in parametric activation analysis, when the ratio: mother half-life to daughter half-life is less than 10, are discussed. The mother-daughter relationships: 47 Ca/ 47 Sc; 95 Zr/ 95 Nb; 140 Ba/ 140 La; 99 Mo/ 99m Tc and 115 Cd/ 115m In are selected as models for the study. The cases when the radionuclide of interest is formed through both direct and indirect routes are also analyzed. As illustrative example, the direct reaction and the reaction chain: 47 Ti(n,p) 47 Sc/ 46 Ca(n,γ) 47 Ca(β - ) 47 Sc are evaluated with respect to the determination of the elements involved and their reciprocal interferences. (author)

Conflict management of mothers and daughters belonging to individualistic and collectivistic cultural backgrounds: a comparative study.

Science.gov (United States)

Gilani, N P

1999-12-01

Research on the mother-daughter relationship during adolescence is mostly conducted in Western and European cultures where individualism is stressed. To examine ethnic/cultural differences and similarities in this relationship, 80 dyads of British (white) and Pakistani mothers and their adolescent daughters were studied. On the basis of the theories of cultural variability dimension and conflict face negotiation, it was hypothesized that mothers and daughters from the two cultures would use different styles of handling disagreements/conflicts. That is, Pakistani mothers and daughters would use an avoiding style, whereas British mothers and daughters would use either a dominating or compromising style, to a greater degree. It was also argued that Pakistani daughters and mothers will express more intimacy and relational harmony, will exhibit greater connectedness and mutuality and demonstrate lesser individuality and self-assertion compared to their British counterparts. However, it appeared that both the groups used an avoiding style equally, although the British group used a dominating style more than Pakistani group. As hypothesized, Pakistani mothers and daughters expressed more intimacy, relational harmony, connectedness and mutuality and lesser individuality than British mothers and daughters. Copyright 1999 The Association for Professionals in Services for Adolescents.

Identification of let-7-regulated oncofetal genes

DEFF Research Database (Denmark)

Boyerinas, Benjamin; Park, Sun-Mi; Shomron, Noam

2008-01-01

-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, suggesting that let-7-regulated oncofetal genes (LOG) may become reexpressed in cancer cells. Using comparative bioinformatics, we have identified 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP. IMP-1...

Background concentrations of radon and radon daughters in Canadian homes

International Nuclear Information System (INIS)

McGregor, R.G.; Vasudev, P.; Letourneau, E.G.; McCullough, R.S.; Prantl, F.A.; Taniguchi, H.

1980-01-01

Measurements of radon and radon daughters were carried out in 14 Canadian cities on a total of 9999 homes selected in a statistically random manner. The geometric means of the different cities varied from 0.14 to 0.88 pCi/l. for radon and 0.0009 to 0.0036 Working Levels for radon daughters. The radon originates from natural radioactivity in the soil surrounding the homes. (author)

Older Parents Benefit More in Health Outcome From Daughters' Than Sons' Emotional Care in China.

Science.gov (United States)

Zeng, Yi; Brasher, Melanie Sereny; Gu, Danan; Vaupel, James W

2016-12-01

To examine whether older parents in China would benefit more from daughters' care than from sons' emotional care. Analysis of the unique data sets of the Chinese Longitudinal Healthy Longevity Survey conducted in 2002, 2005, and 2008-2009 in 22 provinces. As compared with having son(s), having daughter(s) is significantly more beneficial at older ages in China, with regard to maintaining higher cognitive capacity and reducing mortality risk. Such daughter advantages in providing emotional care to older parents are more profound among the oldest-old aged 80+ as compared with the young-old aged 65 to 79 and surprisingly more profound in rural areas as compared with urban areas, even though son preference is much more common among rural residents. We describe how educational campaigns aimed at informing the public about the benefits of daughter(s) for older parents' health outcome could help promote gender equality and reduce traditional son preference, especially in rural China.

Control of daughter centriole formation by the pericentriolar material: Control of centriole duplication

OpenAIRE

Loncarek, Jadranka; Hergert, Polla; Magidson, Valentin; Khodjakov, Alexey

2008-01-01

Controlling the number of its centrioles is vital for the cell as supernumerary centrioles result in multipolar mitosis and genomic instability1,2. Normally, just one daughter centriole forms on each mature (mother) centriole3,4; however, a mother centriole can produce multiple daughters within a single cell cycle5,6. The mechanisms that prevent centriole ‘overduplication’ are poorly understood. Here we use laser microsurgery to test the hypothesis that attachment of the daughter centriole to...

Vocational Preferences of Daughters of Alcoholics

Science.gov (United States)

Gade, Eldon M.; Goodman, Ronald E.

1975-01-01

This study was designed to examine the vocational interests of daughters of alcoholics. Mixed support was provided for the assumption that their vocational choices are nonperson oriented. Data did support the prediction of high scores on the realistic and intellectual scales of Holland's Vocational Preference Inventory. (SJL)

In vitro RBE-LET dependence for multiple particle types

DEFF Research Database (Denmark)

Sørensen, Brita Singers; Overgaard, Jens; Bassler, Niels

2011-01-01

Background. In vitro RBE values for various high LET radiation types have been determined for many different cell types. Occasionally it is criticized that RBE for a given endpoint cannot be single-value dependent on LET alone, but also on particle species, due to the different dose deposition...... profiles on microscopic scale. Hence LET is not sufficient as a predictor of RBE, and this is one of the motivations for development of radiobiological models which explicitly depend on the detailed particle energy spectrum of the applied radiation field. The aim of the present study is to summarize...... the available data in the literature regarding the dependency of RBE on LET for different particles. Method. As RBE is highly dependent on cell type and endpoint, we discriminated the RBE-LET relationship for the three investigated cell lines and at the same endpoint (10% survival in colony formation). Data...

CT detection of daughter nodules in hepatocellular carcinoma after lipiodol infusion via the hepatic artery

Energy Technology Data Exchange (ETDEWEB)

Ohishi, Hajime; Ohgami, Syoichi; Katsuragi, Masami

1985-02-01

The detectability of daughter nodules in 80 hepatocellular carcinomas was compared between CT assisted by Lipiodol Ultra Fluid (Lipiodol) infused via the hepatic artery and IHA (Infusion hepatic angiography). Lipiodol infused via the hepatic artery was selectively accumulated in the tumor vessels and the tumors and small daughter nodules appeared as markedly high density areas by CT. 18 cases in which the daughter nodules were detected were identified only by CT. Furthermore, in 38 cases CT demonstrated superior detectability of the daughthr nodules than IHA. In 15 cases the daughter nodules were newly detected in areas other than the invaded area where the primary tumor existed. This method is very effective in the diagnosis of daughter nodules of hepatocellular carcinoma. (author).

A Review: Some biological effects of high LET radiations

Science.gov (United States)

Wiley, A., Jr.

1972-01-01

There are qualitative and quantitative differences in the biological damage observed after exposure to high LET radiation as compared to that caused by low LET radiations. This review is concerned with these differences, which are ultimately reflected at the biochemical, cellular and even whole animal levels. In general, high LET radiations seem to produce biochemical damage which is more severe and possibly less repairable. Experimental data for those effects are presented in terms of biochemical RBE's with consideration of both early and late manifestations. An LET independent process by which significant biochemical damage may result from protons, neutrons and negative pion mesons is discussed.

Einstein's daughter the search for Lieserl

CERN Document Server

Zackheim, Michele

1999-01-01

A thoroughly gripping and groundbreaking investigation into the mysterious fate of Albert Einstein's illegitimate daughter. Albert Einstein fell in love with Mileva Maric, the woman who would become his first wife, when they were students at the Zurich Polytechnic Institute. When Maric conceived a child out of wedlock, she went home to her family in Serbia to have the child. Lieserl Maric Einstein was born in 1902. Though Einstein and Maric married the following year, Lieserl was left in the care of her grandparents and never became a part of the Einstein family. In fact, her very existence was unknown until the recent discovery of a cache of letters between Einstein and Maric. The final reference to Lieserl comes in a September 1903 letter, when, at the age of approximately eighteen months, she simply disappears. What happened to Einstein's daughter is the most potent mystery to emerge from the mythology that surrounds one of the century's legendary figures, owing in large part to the careful and apparent...

Radon and its daughters in vivo

Energy Technology Data Exchange (ETDEWEB)

Rundo, J

1984-05-01

Prolonged exposure to radon should build up a reservoir of radon in body fat and fluids. If the subject moved to an environment with a lower radon concentration from an environment with a higher level of radon, the result would be an exhalation of radon, and the initial exhalation rate of radon should depend of the radon concentration inhaled. This paper describes the behavior of radon and its daughters in vivo and a relationship between the radon exhalation rate and the time after a meal. A major but short-lived postprandial increase in the exhalation rate of radon was observed. The author reports a similar effect in the exhalation rate of radon by persons containing no radium. It should be noted that the possibility exists that a large amount of radon daughters in the chest may interfere in the investigation of possible internal contamination with plutonium or other actinides by external counting. 8 figures.

On the radiation dose to lung tissues from radon daughters

International Nuclear Information System (INIS)

Wise, K.N.

1980-04-01

The work of Harley and Pasternak on calculating dose conversion factors for radon daughters is re-examined. It is found that their estimates of the deposit of radon daughters on the lung airways are too low and the factor for converting from equilibrium activity of radon daughters on the airways to dose to basal cells is too high; these are re-calculated. However, it is shown that inter-subject variability of the depth of the basal cells leads to considerable uncertainty in the individual dose. Finally average dose conversion factors are re-calculated for atmospheres which may be charactersitic of underground mines; the dose conversion factors range from 8 mGy/WLM to 40 mGy/WLM as calculated from the Weibel lung model and from 3 mGy/WLM to 17 mGy/WLM as calculated from the Landahl lung model

Owning, letting and demanding second homes

DEFF Research Database (Denmark)

Bloze, Gintautas; Skak, Morten

register data and presents estimations of the probability of owning a second home, the decision to let the second home and the number of let weeks per year. Also income elasticities for primary and second housing demand are estimated. We find a conventional monotonic increase in demand elasticities...... for primary housing demand for non-owners of second homes; however, owners of second homes have the highest income elasticity in the middle income group....

The inactivation of papain by high LET radiations

International Nuclear Information System (INIS)

Bisby, R.H.; Cundall, R.B.; Sims, H.E.; Burns, W.G.

1984-01-01

The effect of varying LET over a wide range (0.2-1570 eV/nm) on the radiation-induced inactivation of the enzyme papain in dilute aqueous solution has been investigated. Measurements of total, reparable and non-reparable inactivation G values in oxygen, nitrous oxide and argon saturated solutions have allowed the contributions to inactivation from radicals and hydrogen peroxide to be evaluated. At high LET the results demonstrate an increasing component due to reaction of the superoxide radical, formed from oxygen produced in the track as a primary radiolysis product. This effect was not observed in our previous study with ribonuclease due to the insensitivity of ribonuclease to inactivation by superoxide and hydrogen peroxide. The results obtained with papain clearly demonstrate a maximum in G(H 2 O 2 ) at an LET of equivalent to 140 eV/nm. Generation of O 2 within the track as a primary radiolysis product at high LET now appears to be confirmed as an important mechanism leading to reduction in the oxygen enhancement ratio for cellular systems exposed to high LET radiations (Baverstock and Burns 1981). (author)

Biological effects of daily inhalation of radon and its short-lived daughters in experimental animals

International Nuclear Information System (INIS)

Palmer, R.F.; Stuart, B.O.; Filipy, R.E.

1973-01-01

Syrian golden hamsters, C57BL mice, and specific-pathogen-free rats were exposed simultaneously in groups of 16 animals each for 90 hours per week to aerosols consisting of radon plus 3000--6000 Working Levels of radon-daughters with and without 18 mg/m 3 carnotite uranium ore dust. Condensation nuclei concentrations ranged from 2000--4000 per ml and from 90,000--120,000 per ml in the chamber without and with uranium ore dust, respectively. At 4 months of exposure only one of the rodents remained alive. Histopathology of radon-daughter exposed mice includes acute interstitial pneumonitis, severe pulmonary congestion, and supperative rhinitis; mice inhaling radon-daughters with ore showed these lesions plus macrophage proliferation, alveolar septal cell hyperplasia, and bronchial epithelial hyperplasia. Hamsters inhaling radon-daughters showed proliferating lesions characterized by alveolar septal thickening, bronchiolar epithelial hyperplasia, septal fibrosis, and occasionally adenomatoid metaplasia and squamous metaplasia. Hamsters inhaling radon-daughters with ore dust showed similar effects plus granulomatous response and intense septal fibrosis. Rats inhaling radon-daughters showed lesions similar to those of hamsters but more focalized with classic radiation pneumonitis; rats exposed to radon-daughters with ore showed similar lesions, with greater consolidation and pneumoconiosis. These findings will be discussed in relation to pulmonary pathology in uranium miners

Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation

Science.gov (United States)

Shukla, Anil; Kong, Dong; Sharma, Meena; Magidson, Valentin; Loncarek, Jadranka

2015-01-01

Centrosome overduplication promotes mitotic abnormalities, invasion and tumorigenesis. Cells regulate the number of centrosomes by limiting centriole duplication to once per cell cycle. The orthogonal orientation between a mother and a daughter centriole, established at the time of centriole duplication, is thought to block further duplication of the mother centriole. Loss of orthogonal orientation (disengagement) between two centrioles during anaphase is considered a licensing event for the next round of centriole duplication. Disengagement requires the activity of Polo-like kinase 1 (Plk1), but how Plk1 drives this process is not clear. Here we employ correlative live/electron microscopy and demonstrate that Plk1 induces maturation and distancing of the daughter centriole, allowing reduplication of the mother centriole even if the original daughter centriole is still orthogonal to it. We find that mother centrioles can undergo reduplication when original daughter centrioles are only ∼80 nm apart, which is the distance centrioles normally reach during prophase. PMID:26293378

Examining the Impact of Maternal Health, Race, and Socioeconomic Status on Daughter's Self-Rated Health Over Three Decades.

Science.gov (United States)

Shippee, Tetyana P; Rowan, Kathleen; Sivagnanam, Kamesh; Oakes, J Michael

2015-09-01

This study examines the role of mother's health and socioeconomic status on daughter's self-rated health using data spanning three decades from the National Longitudinal Surveys of Mature Women and Young Women (N = 1,848 matched mother-daughter pairs; 1,201 White and 647 African American). Using nested growth curve models, we investigated whether mother's self-rated health affected the daughter's self-rated health and whether socioeconomic status mediated this relationship. Mother's health significantly influenced daughters' self-rated health, but the findings were mediated by mother's socioeconomic status. African American daughters reported lower self-rated health and experienced more decline over time compared with White daughters, accounting for mother's and daughter's covariates. Our findings reveal maternal health and resources as a significant predictor of daughters' self-rated health and confirm the role of socioeconomic status and racial disparities over time. © The Author(s) 2015.

Bio-mathematical models for radon daughters inhalation. The ModeLung software

International Nuclear Information System (INIS)

Tomulescu, Vlad C.; Rusu, Mircea

2002-01-01

Radon and its decay daughters are the most important sources for natural irradiation of population. ModeLung software is based on the human respiratory tract compartment model and is computing radiation doses on several internal organs and tissues for subjects inhaling radon daughters attached to aerosols. Radiation doses are presented for several subjects performing different types of activity under specific environmental conditions. (authors)

Mother-daughter correlation of central obesity and other noncommunicable disease risk factors: Tehran Lipid and Glucose Study.

Science.gov (United States)

Heidari, Zahra; Hosseinpanah, Farhad; Barzin, Maryam; Safarkhani, Maryam; Azizi, Fereidoun

2015-03-01

This study aimed to investigate the mother-daughter correlation for central obesity and other noncommunicable disease risk factors. The authors used metabolic and anthropometric data from the Tehran Lipid and Glucose Study, enrolling 1041 mother-daughter pairs for the current study. Three age strata were defined: 3 to 9 years for childhood (146 mother-daughter pairs), 10 to 17 years for adolescence (395 mother-daughter pairs), and 18 to 25 years for early adulthood (500 mother-daughter pairs). Familial associations for central obesity and other noncommunicable disease risk factors were assessed. The prevalence of central obesity was 44.7% in mothers and 11.2% in daughters (6.2% in the 3-9, 19.2% in the 10-17, and 6.4% in the 18-25 years groups). Mothers with central obesity were more likely than nonobese mothers to have daughters with central obesity (10.5% and 1.7%, respectively; P = .0001). Central obesity indices among daughters were positively correlated with those of their mothers in all 3 age strata. Correlations for other noncommunicable disease risk factors were analyzed before and after adjusting the risk factor levels for mothers' and daughters' waist circumferences (WCs) within each group to determine whether risk factor correlations were, in part, a result of the central obesity correlations. After the non-communicable disease risk factor levels of participants were adjusted for their WCs, the mother-daughter correlations remained significant. The consistent association of central obesity between mothers and daughters may indicate the key role that could be played by the mother in the primary prevention of central obesity, particularly in high-risk families. © 2012 APJPH.

High and Low LET Radiation Differentially Induce Normal Tissue Damage Signals

International Nuclear Information System (INIS)

Niemantsverdriet, Maarten; Goethem, Marc-Jan van; Bron, Reinier; Hogewerf, Wytse; Brandenburg, Sytze; Langendijk, Johannes A.; Luijk, Peter van; Coppes, Robert P.

2012-01-01

Purpose: Radiotherapy using high linear energy transfer (LET) radiation is aimed at efficiently killing tumor cells while minimizing dose (biological effective) to normal tissues to prevent toxicity. It is well established that high LET radiation results in lower cell survival per absorbed dose than low LET radiation. However, whether various mechanisms involved in the development of normal tissue damage may be regulated differentially is not known. Therefore the aim of this study was to investigate whether two actions related to normal tissue toxicity, p53-induced apoptosis and expression of the profibrotic gene PAI-1 (plasminogen activator inhibitor 1), are differentially induced by high and low LET radiation. Methods and Materials: Cells were irradiated with high LET carbon ions or low LET photons. Cell survival assays were performed, profibrotic PAI-1 expression was monitored by quantitative polymerase chain reaction, and apoptosis was assayed by annexin V staining. Activation of p53 by phosphorylation at serine 315 and serine 37 was monitored by Western blotting. Transfections of plasmids expressing p53 mutated at serines 315 and 37 were used to test the requirement of these residues for apoptosis and expression of PAI-1. Results: As expected, cell survival was lower and induction of apoptosis was higher in high -LET irradiated cells. Interestingly, induction of the profibrotic PAI-1 gene was similar with high and low LET radiation. In agreement with this finding, phosphorylation of p53 at serine 315 involved in PAI-1 expression was similar with high and low LET radiation, whereas phosphorylation of p53 at serine 37, involved in apoptosis induction, was much higher after high LET irradiation. Conclusions: Our results indicate that diverse mechanisms involved in the development of normal tissue damage may be differentially affected by high and low LET radiation. This may have consequences for the development and manifestation of normal tissue damage.

A homeostatic clock sets daughter centriole size in flies

Science.gov (United States)

Aydogan, Mustafa G.; Steinacker, Thomas L.; Novak, Zsofia A.; Baumbach, Janina; Muschalik, Nadine

2018-01-01

Centrioles are highly structured organelles whose size is remarkably consistent within any given cell type. New centrioles are born when Polo-like kinase 4 (Plk4) recruits Ana2/STIL and Sas-6 to the side of an existing “mother” centriole. These two proteins then assemble into a cartwheel, which grows outwards to form the structural core of a new daughter. Here, we show that in early Drosophila melanogaster embryos, daughter centrioles grow at a linear rate during early S-phase and abruptly stop growing when they reach their correct size in mid- to late S-phase. Unexpectedly, the cartwheel grows from its proximal end, and Plk4 determines both the rate and period of centriole growth: the more active the centriolar Plk4, the faster centrioles grow, but the faster centriolar Plk4 is inactivated and growth ceases. Thus, Plk4 functions as a homeostatic clock, establishing an inverse relationship between growth rate and period to ensure that daughter centrioles grow to the correct size. PMID:29500190

Environmental radon and radon daughter dosimetry in the respiratory tract

International Nuclear Information System (INIS)

McPherson, R.B.

1979-04-01

This report describes work performed by Pacific Northwest Laboratory (PNL) for the Nuclear Regulatory Commission's program to determine safety and costs related to decommissioning nuclear fuel cycle facilities. Individual dose factors for the inhalation of radon and its daughter products are calculated for use in environmental dose assessments. The calculated committed dose equivalent factors for 222 Rn and its daughters are tabulated for lungs, bronchi tract and other organs. An activity median aerodynamic diameter of 0.1 μm was used. The dose to an individual is calculated by multiplying the estimated intake from inhalation for a particular radionuclide by the corresponding dose factor. A working level month-to-dose conversion factor is calculated to be 1 rad/WLM to the epithelial tissue of the T-B region, assuming 100% daughter equilibrium and 10% free 218 Po ions. This value is in reasonable agreement with recently reported values

Radiation exposure due to radon and radon daughters

International Nuclear Information System (INIS)

Ullmann, W.

1976-01-01

Underground miners working over long periods of time in mines with a high content of radon and radon daughters belong to that group of occupationally exposed persons who are subject to the greatest somatic risk, with values especially high if the permissible dose limits are exceeded. Follwing an overview of the permissible limits currently in use for radon and radon daughters as well as the results of examinations performed in nationally-owned underground mining of the G.D.R., considerations are presented on the measuring quantities requisite for statistical, control and safety measurements in this field. Finally, conclusions are drawn concerning the measuring procedures and instruments to be employed for practical work. (author)

TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

Science.gov (United States)

Pedersen, Rune Troelsgaard; Kruse, Thomas; Nilsson, Jakob

2015-01-01

Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Replication stress delays replication into G2/M, which in turn impairs proper chromosome segregation and inflicts DNA damage on the daughter cells. Here we show that TopBP1 forms foci upon mitotic entry. In early mitosis, TopBP1 marks sites of and promotes unscheduled DNA synthesis. Moreover, TopBP1 is required for focus formation of the structure-selective nuclease and scaffold protein SLX4 in mitosis. Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next cell cycle, showing that TopBP1 acts to reduce transmission of DNA damage to G1 daughter cells. Based on these results, we propose that TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 and by facilitating unscheduled DNA synthesis. PMID:26283799

Asterless licenses daughter centrioles to duplicate for the first time in Drosophila embryos.

Science.gov (United States)

Novak, Zsofia A; Conduit, Paul T; Wainman, Alan; Raff, Jordan W

2014-06-02

Centrioles form centrosomes and cilia, and defects in any of these three organelles are associated with human disease [1]. Centrioles duplicate once per cell cycle, when a mother centriole assembles an adjacent daughter during S phase. Daughter centrioles cannot support the assembly of another daughter until they mature into mothers during the next cell cycle [2-5]. The molecular nature of this daughter-to-mother transition remains mysterious. Pioneering studies in C. elegans identified a set of core proteins essential for centriole duplication [6-12], and a similar set have now been identified in other species [10, 13-18]. The protein kinase ZYG-1/Sak/Plk4 recruits the inner centriole cartwheel components SAS-6 and SAS-5/Ana2/STIL, which then recruit SAS-4/CPAP, which in turn helps assemble the outer centriole microtubules [19, 20]. In flies and humans, the Asterless/Cep152 protein interacts with Sak/Plk4 and Sas-4/CPAP and is required for centriole duplication, although its precise role in the assembly pathway is unclear [21-24]. Here, we show that Asl is not incorporated into daughter centrioles as they assemble during S phase but is only incorporated once mother and daughter separate at the end of mitosis. The initial incorporation of Asterless (Asl) is irreversible, requires DSas-4, and, crucially, is essential for daughter centrioles to mature into mothers that can support centriole duplication. We therefore propose a "dual-licensing" model of centriole duplication, in which Asl incorporation provides a permanent primary license to allow new centrioles to duplicate for the first time, while centriole disengagement provides a reduplication license to allow mother centrioles to duplicate again. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Radon-daughter exposures in energy-efficient buildings

International Nuclear Information System (INIS)

Nero, A.V.; Berk, J.V.; Boegel, M.L.; Hollowell, C.D.; Ingersoll, J.G.; Nazaroff, W.W.

1981-10-01

A radon concentration of 1 pCi/1 (37 Bq/m 3 ) appears to lie in the range that is typical for air inside US residential buildings. Moreover, some US residences have concentrations higher than 1 pCi/1, sometimes by an order of magnitude, implying significant individual risk to occupants. For typical radon daughter equilibrium ratios, this concentration corresponds to a radon daughter exposure rate of 0.2 working level months (WLM) per year. This exposure rate may account for a significant lung cancer incidence if data on lung cancers per unit exposure in miners are applicable to such low exposures. Reductions in air exchange rates may rise the typical exposure rate and even increase it to unacceptable levels in some cases. Measures that reduce energy use by reducing natural infiltration or mechanical ventilation in new or retrofit buildings are therefore undergoing severe scrutiny. Lawrence Berkeley Laboratory has performed measurements in buildings specifically designed to use energy efficiently or utilize solar heating. In many of these buildings radon concentrations appear to arise primarily from soil underlying the buildings. Measures to control higher levels, e.g., by mechanical ventilation with heat recuperation, appear to be economical. However, to evaluate energy-saving programs adequately requires a much more comprehensive characterization of radon sources (for example, by geographical area) and a much fuller understanding of the dynamics of radon and its daughters indoors than now exist

Experimental pulmonary carcinogenesis by radon and its daughters

International Nuclear Information System (INIS)

Sato, Fumiaki

1989-01-01

Information on experimental pulmonary carcinogenesis by radon and its daughters has come mostly from experiments carried out in France and United States of America. In rats a dose response relation was estimated to be linear with dose at low dose region. Studies of rats exposed daily to radon and radon daughters indicated that the frequency of pulmonary cancer at total exposure greater than 3000 WLM was greater when the exposure rates were low. At low total exposures the dose-rate effect was less apparent. Cigarette smoke increased the pulmonary cancer in rats but decreased in dogs. The decrease may be due to a decrease of absorbed doses with increased secretion of mucus and to an enhancement of mucociliary clearance. After inhalation of 222 Ru at equilibrium with radon daughters, rats were inoculated intrapleurally with asbestos fibres or glass fibres. The additive co-carcinogenic effects of this type of insult were demonstrated by the increased incidence of malignant thoracic tumours. As for species differences, dogs and hamsters are relatively resistant to cancer induction and rats are sensitive. While bronchogenic carcinomas are the most frequently observed radiation-induced pulmonary cancer in humans, bronchioloalveolar carcinomas are the most frequent type in most animal species. (author)

Hispanic maternal influences on daughters' unhealthy weight control behaviors: The role of maternal acculturation, adiposity, and body image disturbances.

Science.gov (United States)

Olvera, Norma; Matthews-Ewald, Molly R; McCarley, Kendall; Scherer, Rhonda; Posada, Alexandria

2016-12-01

This study examined whether maternal adiposity, acculturation, and perceived-ideal body size discrepancy for daughters were associated with daughters' engagement in unhealthy weight control behaviors. A total of 97 Hispanic mother-daughter dyads completed surveys, rated a figure scale, and had their height, weight, and adiposity assessed. Mothers (M age =39.00, SD=6.20 years) selected larger ideal body sizes for their daughters (M age =11.12, SD=1.53 years) than their daughters selected for themselves. Mothers had a smaller difference between their perception of their daughters' body size and ideal body size compared to the difference between their daughters' selection of their perceived and ideal body size. More acculturated mothers and those mothers with larger waist-to-hip ratios were more likely to have daughters who engaged in unhealthy weight control behaviors. These findings highlight the relevant role that maternal acculturation and adiposity may have in influencing daughters' unhealthy weight control behaviors. Published by Elsevier Ltd.

Peoples' perception of mother-daughter sexual communication ...

African Journals Online (AJOL)

Peoples' perception of mother-daughter sexual communication patterns and adolescent girls reproductive health in Enugu North ... become vulnerable to reproductive health problems such as teenage pregnancy, STDs, and HIV/AIDS. ... improved sexual communication skills on sexuality education were recommended.

Biomarkers specific to densely-ionising (high LET) radiations

International Nuclear Information System (INIS)

Brenner, D.J.; Okladnikova, N.; Hande, P.; Burak, L.; Geard, C.R.; Azizova, T.

2001-01-01

There have been several suggestions of biomarkers that are specific to high LET radiation. Such a biomarker could significantly increase the power of epidemiological studies of individuals exposed to densely-ionising radiations such as alpha particles (e.g. radon, plutonium workers, individuals exposed to depleted uranium) or neutrons (e.g. radiation workers, airline personnel). We discuss here a potentially powerful high LET biomarker (the H value) which is the ratio of induced inter-chromosomal aberrations to intra-arm aberrations. Both theoretical and experimental studies have suggested that this ratio should differ by a factor of about three between high LET radiation and any other likely clastogen, and will yield more discrimination than the previously suggested F value (ratio of inter-chromosomal aberrations to intra-chromosomal inter-arm aberrations). Evidence of the long-term stability of such chromosomal biomarkers has also been generated. Because these stable intra-arm and inter-chromosomal aberrations are (1) frequent and (2) measurable at long times after exposure, this H value appears to be a practical biomarker of high LET exposure, and several in vitro studies have confirmed the approach for unstable aberrations. The approach is currently being tested in a population of Russian radiation workers exposed several decades ago to high- or low LET radiation. (author)

Like Mother, Like Daughter?: Matrilineal Opposition in African American Mulatta Melodrama

Directory of Open Access Journals (Sweden)

Anna Pochmara

2017-10-01

Full Text Available The article juxtaposes representations of mothers and daughters in selected African American novels that feature near-white female protagonists: W. W. Brown’s Clotel, Or the President’s Daughter (1853, Frances E. W. Harper’s Iola Leroy (1892, Charles Chesnutt’s The House behind the Cedars (1900, and Pauline Hopkins’s Hagar’s Daughter (1902. It explores the matrilineal opposition through a formalist close analysis of the melodramatic poetics of the texts and examines the political significance of such aesthetic choices. The novels expose the American history of interracial relations through their foregrounding of the mulatta protagonists and numerous scenes of anagnorisis of their multiracial identities. Simultaneously, their “erotics of politics” rewards the choice of a black spouse and thus celebrates the emergence of the self-determined black community.

Size distribution of radon daughter particles in uranium mine atmospheres

International Nuclear Information System (INIS)

George, A.C.; Hinchliffe, L.; Sladowski, R.

1977-07-01

An investigation of the particle size distribution and other properties of radon daughters in uranium mines was reported earlier but only summaries of the data were presented. This report consists mainly of tables of detailed measurements that were omitted in the original article. The tabulated data include the size distributions, uncombined fractions and ratios of radon daughters as well as the working levels, radon concentrations, condensation nuclei concentrations, temperature, and relative humidity. The measurements were made in 27 locations in four large underground mines in New Mexico during typical mining operations. The size distributions of the radon daughters were log normal. The activity median diameters ranged from 0.09 μm to 0.3 μm with a mean of 0.17 μm. Geometric standard deviations were from 1.3 to 4 with a mean of 2.7. Uncombined fractions expressed in accordance with the ICRP definition ranged from 0.004 to 0.16 with a mean of 0.04

Reciprocity in Intergenerational Support: A Comparison of Chinese and German Adult Daughters

Science.gov (United States)

Schwarz, Beate; Trommsdorff, Gisela; Zheng, Gang; Shi, Shaohua

2010-01-01

This study investigates how Chinese and German adult daughters evaluate the norm of reciprocity and the unbalanced exchange of support in relation to their aging parents. Women from rural and urban China (n = 292) and from Germany (n = 264) have participated in this study. Results show that for the German daughters, differently from rural Chinese…

Presence of UV-endonuclease sensitive sites in daughter DNA of UV-irradiated mammalian cells

International Nuclear Information System (INIS)

D'Ambrosio, S.; Setlow, R.B.

1978-02-01

Asynchronous Chinese hamster cells were irradiated with 10 Jm -2 uv radiation and 0.25 to 4 hours later pulse-labeled with [ 3 H]thymidine. Cells synchronized by shaking off mitotic and G 1 cells were irradiated in either the G 1 -phase or S-phase of the cell cycle and pulse-labeled with [ 3 H]thymidine in the S-phase. After a 12 to 14 hour chase in unlabeled medium, the DNA was extracted, incubated with Micrococcus luteus uv-endonuclease and sedimented in alkaline sucrose. The number of endonuclease sensitive sites decreased as the time between uv irradiation and pulse-labeling of daughter DNA increased. Further, there were significantly less endonuclease sensitive sites in the daughter DNA from cells irradiated in the G 1 -phase than in the S-phase. These data indicate that very few, if any, dimers are transferred from parental DNA to daughter DNA and that the dimers detected in daughter DNA may be due to the irradiation of replicating daughter DNA before labeling

Protocol for the estimation of average indoor radon-daughter concentrations: Second edition

International Nuclear Information System (INIS)

Langner, G.H. Jr.; Pacer, J.C.

1988-05-01

The Technical Measurements Center has developed a protocol which specifies the procedures to be used for determining indoor radon-daughter concentrations in support of Department of Energy remedial action programs. This document is the central part of the protocol and is to be used in conjunction with the individual procedure manuals. The manuals contain the information and procedures required to implement the proven methods for estimating average indoor radon-daughter concentration. Proven in this case means that these methods have been determined to provide reasonable assurance that the average radon-daughter concentration within a structure is either above, at, or below the standards established for remedial action programs. This document contains descriptions of the generic aspects of methods used for estimating radon-daughter concentration and provides guidance with respect to method selection for a given situation. It is expected that the latter section of this document will be revised whenever another estimation method is proven to be capable of satisfying the criteria of reasonable assurance and cost minimization. 22 refs., 6 figs., 3 tabs

Mine engineering and ventilation problems unique to the control of radon daughters

International Nuclear Information System (INIS)

Rock, R.L.

1975-01-01

Quality and quantity of ventilation are the two interrelated but key factors in any radon-daughter control programme. The better the intake air quality (little or no contamination from radon and its daughters), the less are the total air requirements for ventilation of active mining areas. Engineering principles for quantity distribution of air through underground working areas are straightforward and the formulae and theories governing forced ventilation are not within the scope of this paper. Rather, this paper discusses the principal methods of utilizing mine planning to facilitate radon-daughter control and also treats the more subtle features of mine ventilation which are especially critical in the ventilation of mines where radon gas constitutes an environmental contamination problem. (author)

White piedra in a mother and daughter.

Science.gov (United States)

Roshan, Anupama S; Janaki, C; Parveen, B

2009-07-01

White Piedra is a superficial fungal infection of the hair caused by Trichosporon asahii. It is also known as trichomycosis nodosa or trichomycosis nodularis. We report two cases of White Piedra in a mother and her daughter for the rarity of such occurrence.

EWLMII: a measurement and data-acquisition system for radon daughters

Energy Technology Data Exchange (ETDEWEB)

Keefe, D.J.; McDowell, W.P.; Groer, P.G.

1981-01-01

Development of new methods and instruments for the measurement of WL and Rn-daughter concentrations has been in progress for several years. However, efficient methods of data acquisition has not been the primary thrust of this research. If large volumes of data from automated instruments are to be efficiently analyzed, a built in data acquisition system is needed. One such instrument, the EWLMII, is described. The need for accelerated research for the understanding and control of Rn-daughters can be enhanced by such an instrument.

EWLMII: a measurement and data-acquisition system for radon daughters

International Nuclear Information System (INIS)

Keefe, D.J.; McDowell, W.P.; Groer, P.G.

1981-01-01

Development of new methods and instruments for the measurement of WL and Rn-daughter concentrations has been in progress for several years. However, efficient methods of data acquisition has not been the primary thrust of this research. If large volumes of data from automated instruments are to be efficiently analyzed, a built in data acquisition system is needed. One such instrument, the EWLMII, is described. The need for accelerated research for the understanding and control of Rn-daughters can be enhanced by such an instrument

How My Daughter Taught Me to Teach: The Importance of Active Communication

Science.gov (United States)

Hunt-Gierut, Deborah

2011-01-01

In this article, the author shares how her daughter, who was diagnosed with a profound hearing loss when she was a year old, taught her to teach, and demonstrates the importance of active communication. Teaching her daughter English as her second language has posed many challenges, but has also revealed successful strategies that the author has…

Caring for a Daughter with Intellectual Disabilities in Managing Menstruation: A Mother's Perspective

Science.gov (United States)

Chou, Yueh-Ching; Lu, Zxy-Yann Jane

2012-01-01

Background: The concerns of mothers and their experiences while providing help to their daughters with intellectual disability (ID) and considerable support needs during menstruation have rarely been addressed. This qualitative study explored mothers' experiences and perceptions of managing their daughters' menstruation. Method: Twelve Taiwanese…

In vitro cellular transformation induced by charged particles of defined LET

International Nuclear Information System (INIS)

Hei, T.K.; Hall, E.J.; Komatsu, K.; Goldhagen, P.

1985-01-01

Cytotoxicity and neoplastic transformation were scored in the C/sub 3/H 10T1/2 cell system following irradiation with protons, deuterons and helium-3 ions of defined LET in the track segment mode. The charged particles were accelerated at the Radiological Research Accelerator Facility at the Nevis Laboratories of Columbia University and provided a range of LET values from 10 to 175 keV/μm. Exponential phase cultures of C3H 10T1/2 cells, growing on a thin mylar surface were irradiated with charged particles of various LET values and subsequently replated onto commercial plastic petri dishes. The cultures were incubated for six weeks at which time they were fixed, stained and type II and III scored as transformants. Over the range of LET values studied thus far, it was found that as the LET of the charged particles increased, the shoulder of the survival curves decreased and approached an exponential function of dose at LET values of 100 keV/μm and above. The transformation incidence, likewise, showed a direct correlation with LET over the dose ranges examined

Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma

Science.gov (United States)

Powers, John T; Tsanov, Kaloyan M; Pearson, Daniel S; Roels, Frederik; Spina, Catherine S; Ebright, Richard; Seligson, Marc; de Soysa, Yvanka; Cahan, Patrick; Theiβen, Jessica; Tu, Ho-Chou; Han, Areum; Kurek, Kyle C; LaPier, Grace S; Osborne, Jihan K; Ross, Samantha J; Cesana, Marcella; Collins, James J; Berthold, Frank; Daley, George Q

2016-01-01

Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumor suppressor family of microRNAs implicated in numerous cancers. LIN28B, an inhibitor of let-7 biogenesis, is overexpressed in neuroblastoma and has been reported to regulate MYCN. However, here we show that LIN28B is dispensable in MYCN-amplified neuroblastoma cell lines, despite de-repression of let-7. We further demonstrate that MYCN mRNA levels in amplified disease are exceptionally high and sufficient to sponge let-7, which reconciles the dispensability of LIN28B. We found that genetic loss of let-7 is common in neuroblastoma, inversely associated with MYCN-amplification, and independently associated with poor outcomes, providing a rationale for chromosomal loss patterns in neuroblastoma. We propose that let-7 disruption by LIN28B, MYCN sponging, or genetic loss is a unifying mechanism of neuroblastoma pathogenesis with broad implications for cancer pathogenesis. PMID:27383785

EXPLORING FATHER-DAUGHTER RELATIONSHIP IN THE ABHIJNANSAKUNTALAM AND HAMLET

Directory of Open Access Journals (Sweden)

Dr. Naveen K. MEHTA

2011-05-01

Full Text Available In Shakespearian dramas, the kingly authority merges with the authority of a father. Shakespeare uses the father-daughter relationship fundamentally to discredit the practice of possession and the attitude of cupidity which was under attack in the Renaissance. During the world’s famous Indian dramatist Kalidasa period, the father was considered to be the head of the family. Kalidasa's immortal works also suggest that counsels of parents and teachers must be obeyed without any hesitation. The present paper is an attempt to explore the intricacies of the father-daughter relationship in the „Abhijnansakuntalam” and „Hamlet”, „Prince of Denmark”

African American Mother–Daughter Communication About Sex and Daughters’ Sexual Behavior: Does College Racial Composition Make a Difference?

Science.gov (United States)

Bynum, Mia Smith

2014-01-01

This study examined the influence of African American mothers’ communication about sexual topics on the sexual attitudes and behavior of their college-enrolled daughters. Daughters were enrolled at a historically Black college/university (HBCU) or a predominantly White institution (PWI) to assess whether and how college racial context might affect daughters’ sexual attitudes and behavior. Findings indicated that daughters at the HBCU had less permissive attitudes about premarital sex than their counterparts at the PWI. This result was especially true for daughters of mothers with more conservative attitudes about premarital sex and who discussed such topics infrequently. Last, the combination of positive mother–daughter communication and fewer discussions about sexual topics resulted in lower levels of sexual experience among the daughters. PMID:17500604

Applicability of LET to single events in microelectronic structures

Science.gov (United States)

Xapsos, Michael A.

1992-12-01

LET is often used as a single parameter to determine the energy deposited in a microelectronic structure by a single event. The accuracy of this assumption is examined for ranges of ion energies and volumes of silicon appropriate for modern microelectronics. It is shown to be accurate only under very restricted conditions. Significant differences arise because (1) LET is related to energy lost by the ion, not energy deposited in the volume; and (2) LET is an average value and does not account for statistical variations in energy deposition. Criteria are suggested for determining when factors other than LET should be considered, and new analytical approaches are presented to account for them. One implication of these results is that improvements can be made in space upset rate predictions by incorporating the new methods into currently used codes such as CREME and CRUP.

MicroRNA let-7, T cells, and patient survival in colorectal cancer

Science.gov (United States)

Dou, Ruoxu; Nishihara, Reiko; Cao, Yin; Hamada, Tsuyoshi; Mima, Kosuke; Masuda, Atsuhiro; Masugi, Yohei; Shi, Yan; Gu, Mancang; Li, Wanwan; da Silva, Annacarolina; Nosho, Katsuhiko; Zhang, Xuehong; Meyerhardt, Jeffrey A.; Giovannucci, Edward L.; Chan, Andrew T.; Fuchs, Charles S.; Qian, Zhi Rong; Ogino, Shuji

2016-01-01

Experimental evidence suggests that the let-7 family of noncoding RNAs suppresses adaptive immune responses, contributing to immune evasion by the tumor. We hypothesized that the amount of let-7a and let-7b expression in colorectal carcinoma might be associated with limited T-lymphocyte infiltrates in the tumor microenvironment and worse clinical outcome. Utilizing the molecular pathological epidemiology resources of 795 rectal and colon cancers in two U.S.-nationwide prospective cohort studies, we measured tumor-associated let-7a and let-7b expression levels by quantitative reverse-transcription PCR, and CD3+, CD8+, CD45RO (PTPRC)+, and FOXP3+ cell densities by tumor tissue microarray immunohistochemistry and computer-assisted image analysis. Logistic regression analysis and Cox proportional hazards regression were used to assess associations of let-7a (and let-7b) expression (quartile predictor variables) with T-cell densities (binary outcome variables) and mortality, respectively, controlling for tumor molecular features, including microsatellite instability, CpG island methylator phenotype, LINE-1 methylation, and KRAS, BRAF, and PIK3CA mutations. Compared with cases in the lowest quartile of let-7a expression, those in the highest quartile were associated with lower densities of CD3+ [multivariate odds ratio (OR), 0.40; 95% confidence interval (CI), 0.23 to 0.67; Ptrend = 0.003] and CD45RO+ cells (multivariate OR, 0.31; 95% CI, 0.17 to 0.58; Ptrend = 0.0004), and higher colorectal cancer-specific mortality (multivariate hazard ratio, 1.82; 95% CI, 1.42 to 3.13; Ptrend = 0.001). In contrast, let-7b expression was not significantly associated with T-cell density or colorectal cancer prognosis. Our data support the role of let-7a in suppressing antitumor immunity in colorectal cancer, and suggest let-7a as a potential target of immunotherapy. PMID:27737877

Contribution of radon in natural gas to the dose from aiborne radon-daughters in homes

International Nuclear Information System (INIS)

Barton, C.J.; Moore, R.E.; Rohwer, P.S.

1973-01-01

Data have been obtained on the radon concentration in natural gas supplied to several metropolitan areas in the United States. The average value of 20 pCi/l was selected to estimate the contribution of this source of natural radioactivity to doses from radon-daughters received by individuals in homes. Radon-daughter concentrations in the home atmosphere were calculated by use of computer programs for an 8000 ft 3 house in which 27 ft 3 of gas per day was used for cooking in an unvented kitchen range. The total estimated dose to the bronchial epithelium included contributions from radon plus daughters in the outside ventilation air, each of which was assumed to be present at a concentration of 0.13 pCi/l, and from the radon plus daughters in the natural gas. The latter contribution averaged approximately 3 percent of the total dose. There was a 3.5 percent decrease in the estimated total dose when the air change rate increased from 0.25 to 2.0 per hour. We conclude that radon and radon-daughters entering the home with natural gas produce a negligible fraction of the total dose to the respiratory system of home occupants from airborne radon-daughters

Biological fingerprint of high LET radiation. Brenner hypothesis

International Nuclear Information System (INIS)

Kodama, Yoshiaki; Awa, Akio; Nakamura, Nori

1997-01-01

Hypothesis by Brenner et al. (1994) that in chromosome aberrations in human peripheral lymphocytes induced by radiation exposure, F value (dicentrics/rings) differs dependently on the LET and can be a biomarker of high LET radiation like neutron and α-ray was reviewed and evaluated as follows. Radiation and chromosome aberrations; in this section, unstable aberrations like dicentric and rings (r) and stable ones like translocation and pericentric inversions were described. F value. Brenner hypothesis. Bauchinger's refutation. F value determined by FISH method; here, FISH is fluorescence in situ hybridization. F value in studies by author's Radiation Effect Research Facility. Frequency of chromosome aberration in A-bomb survivors and ESR (ESR: electron spin resonance). The cause for fluctuation of F values. The Brenner hypothesis could not be supported by studies by author's facility, suggesting that the rate of inter-chromosomal and intra-chromosomal exchange abnormalities can not be distinguishable by the radiation LET. This might be derived from the difference in detection technology of r rather than in LET. (K.H.)

Special photographic emulsions for high LET dosimetry

International Nuclear Information System (INIS)

Katz, R.

1978-12-01

The purpose of these investigations into photographic emulsion dosimetry is to attempt to use the photographic emulsion to mimic the response of human tissues to high LET radiations. The program therefore requires that a systematic understanding of the response of mammalian cells to ionizing radiations be achieved. We have been concerned with differences in RBE and in radiation response to both high and LET radiations, and in the interrelationship between observations with these different radiations

Awareness of cervical cancer prevention among mothers of adolescent daughters in Korea: qualitative research.

Science.gov (United States)

Kim, Hae Won; Kim, Duck Hee

2015-05-14

Korean adolescent girls are unprepared for cervical cancer prevention due to the lack of a mandatory policy regarding human papilloma virus (HPV) vaccination and school health education regarding cervical cancer. The aim of this study was to determine how aware mothers are about cervical cancer prevention in their adolescent daughters, with a view to developing strategies for expanding primary cervical cancer prevention for adolescent girls through the mothers' involvement. A qualitative design was employed. Nine mothers with adolescent daughters participated in this study and were interviewed using open-ended questions. The themes were extracted by content analysis. A general living area in Seoul, South Korea. The snowball method was used to select mothers. Five themes emerged. In general, the mothers' awareness of cervical cancer was not clear, and they exhibited a lack of awareness of the importance of having a regular Papanicolaou screening test. The mothers recognised that they were role models for their daughters, and realised and accepted the necessity of educating their daughters regarding cervical cancer; however, they perceived barriers related to the prevention of cervical cancer in their daughters. The mothers recommended enforcing sex education in schools and the provision of financial support for HPV vaccination. The mothers' awareness and preparedness with respect to the prevention of cervical cancer in their adolescent daughters were low and inadequate. Mothers should be informed and motivated to play a role in the education of their daughters regarding cervical cancer prevention. Strategies for disseminating information regarding early cervical cancer prevention for adolescent girls are recommended by communicating with both the girls and their mothers and providing them with education regarding cervical cancer prevention. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to

Randomized controlled trial of an online mother-daughter body image and well-being intervention.

Science.gov (United States)

Diedrichs, Phillippa C; Atkinson, Melissa J; Garbett, Kirsty M; Williamson, Heidi; Halliwell, Emma; Rumsey, Nichola; Leckie, George; Sibley, Chris G; Barlow, Fiona Kate

2016-09-01

Poor body image is a public health issue. Mothers are a key influence on adolescent girls' body image. This study evaluated an accessible, scalable, low-intensity internet-based intervention delivered to mothers (Dove Self Esteem Project Website for Parents) on mothers' and their adolescent daughters' body image and psychosocial well-being. British mother-daughter dyads (N = 235) participated in a cluster randomized controlled trial (assessment-only control; mothers viewed the website without structured guidance [website-unstructured]; mothers viewed the website via a tailored pathway [website-tailored]). Dyads completed standardized self-report measures of body image, related risk factors, and psychosocial outcomes at baseline, 2 weeks post-exposure, 6-week, and 12-month follow-up. Dyadic models showed that relative to the control, mothers who viewed the website reported significantly higher self-esteem at post-exposure (website-tailored), higher weight esteem at 6-week follow-up (website-tailored), lower negative affect at 12-month follow-up (website-tailored), engaged in more self-reported conversations with their daughters about body image at post-exposure and 6-week follow-up, and were 3-4.66 times more likely to report seeking additional support for body image issues at post-exposure (website-tailored), 6-week, and 12-month (website-tailored) follow-up. Daughters whose mothers viewed the website had higher self-esteem and reduced negative affect at 6-week follow-up. There were no differences on daughters' body image, and risk factors among mothers or daughters, at post-exposure or follow-up. Tailoring website content appeared beneficial. This intervention offers a promising 'first-step' toward improving psychosocial well-being among mothers and daughters. In order to further optimize the intervention, future research to improve body image-related outcomes and to understand mechanisms for change would be beneficial. (PsycINFO Database Record (c) 2016 APA, all

Occupational exposure to radon daughters in buildings

International Nuclear Information System (INIS)

Dixon, D.W.

1985-01-01

Results are presented for radon daughter concentrations in 70 premises of either factory-type or office-type in Cornwall. It is concluded that attention may need to be directed to offices in parts of the UK, the principal reason being their generally low ventilation rates. (U.K.)

Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates.

Science.gov (United States)

Duensing, A; Liu, Y; Perdreau, S A; Kleylein-Sohn, J; Nigg, E A; Duensing, S

2007-09-20

Abnormal centrosome numbers are detected in virtually all cancers. The molecular mechanisms that underlie centrosome amplification, however, are poorly characterized. Based on the model that each maternal centriole serves as a template for the formation of one and only one daughter centriole per cell division cycle, the prevailing view is that centriole overduplication arises from successive rounds of centriole reproduction. Here, we provide evidence that a single maternal centriole can concurrently generate multiple daughter centrioles. This mechanism was initially identified in cells treated with the peptide vinyl sulfone proteasome inhibitor Z-L(3)VS. We subsequently found that the formation of more than one daughter at maternal centrioles requires cyclin E/cyclin-dependent kinase 2 as well as Polo-like kinase 4 and that overexpression of these proteins mimics this phenotype in the absence of a proteasome inhibitor. Moreover, we show that the human papillomavirus type 16 E7 oncoprotein stimulates aberrant daughter centriole numbers in part through the formation of more than one daughter centriole at single maternal templates. These results help to explain how oncogenic stimuli can rapidly induce abnormal centriole numbers within a single cell-division cycle and provide insights into the regulation of centriole duplication.

Preliminary evaluation of the control of indoor radon daughter levels in new structures

International Nuclear Information System (INIS)

Fitzgerald, J.E. Jr.; Guimond, R.J.

1976-01-01

As part of its assessment of the radiological impact of the phosphate industry in Florida, the US Environmental Protection Agency has surveyed residences built atop uraniferous reclaimed phosphate mining land. These surveys have shown elevated radon daughter levels to exist in structures built on this land. In order to allow safer use of this land for residential construction, various state-of-the-art radon daughter control technologies were evaluated by the Agency. These included forced ventilation, polymeric sealants, excavation, crawl space construction, and improved slab quality. From a cost-effectiveness evaluation, improved slab quality and crawl space construction were determined to best satisfy the criteria for optimal radon daughter control

Parenting practices, parents' underestimation of daughters' risks, and alcohol and sexual behaviors of urban girls.

Science.gov (United States)

O'Donnell, Lydia; Stueve, Ann; Duran, Richard; Myint-U, Athi; Agronick, Gail; San Doval, Alexi; Wilson-Simmons, Renée

2008-05-01

In urban economically distressed communities, high rates of early sexual initiation combined with alcohol use place adolescent girls at risk for myriad negative health consequences. This article reports on the extent to which parents of young teens underestimate both the risks their daughters are exposed to and the considerable influence that they have over their children's decisions and behaviors. Surveys were conducted with more than 700 sixth-grade girls and their parents, recruited from seven New York City schools serving low-income families. Bivariate and multivariate analyses examined relationships among parents' practices and perceptions of daughters' risks, girls' reports of parenting, and outcomes of girls' alcohol use, media and peer conduct, and heterosexual romantic and social behaviors that typically precede sexual intercourse. Although only four parents thought that their daughters had used alcohol, 22% of the daughters reported drinking in the past year. Approximately 5% of parents thought that daughters had hugged and kissed a boy for a long time or had "hung out" with older boys, whereas 38% of girls reported these behaviors. Parents' underestimation of risk was correlated with lower reports of positive parenting practices by daughters. In multivariate analyses, girls' reports of parental oversight, rules, and disapproval of risk are associated with all three behavioral outcomes. Adult reports of parenting practices are associated with girls' conduct and heterosexual behaviors, but not with their alcohol use. Creating greater awareness of the early onset of risk behaviors among urban adolescent girls is important for fostering positive parenting practices, which in turn may help parents to support their daughters' healthier choices.

Measurements of 222Rn and its daughters and estimation of internal doses to workers in underground buildings

International Nuclear Information System (INIS)

Cao Jianping; Lu Zhizhao; Li Yuanshan

1993-03-01

The results of concentration measuring of 222 Ru and its daughters and estimation of internal doses to workers in the underground buildings at Nanjing city are presented. The double filtering membrane method and Thomas method were used in the monitoring of 222 Rn and its daughters, and the dose conversion factor was taken from the latest UNSCEAR report. Concentration distributions of 222 Rn and its daughters were approximately log-normal. The geometric means for 222 Rn was 40.5 Bq · m -3 and for its daughters was 1.4 x 10 -7 J · m -3 . The equilibrium factor was 0.63. The radioactive equilibrium ratio between short-lived 222 Rn daughters was 1:0.57:0.49. The estimation value of annual effective dose equivalent from 222 Rn daughters to workers working at underground sites was 1.3 mSv, which was 86% higher than that of those working on ground sites

Love Relationships between Mother and Daughter in Beloved and Annie John

OpenAIRE

Kusumoto, Jitsuko; クスモト, ジツコ; 楠元, 実子

2009-01-01

For minority and female, especially young daughters such as Denver inBeloved by Toni Morrison, or Annie in Annie John by Jamaica Kincaid, itis difficult to build own identities under the suppression and the solitudethey face. For them, the love and affection from and to their mothersbecome a crucial factor in their mental growth. This paper focuses on thedevelopment of two daughters' identities though love relationships withtheir mothers. We will examine the characteristics of love and emotio...

Marital and Parent-Child Relationships in Families with Daughters Who Have Eating Disorders

Science.gov (United States)

Latzer, Yael; Lavee, Yoav; Gal, Sharon

2009-01-01

This study assesses and compares the relationship between parents' marital quality, parent-child relationship, and severity of eating-related psychopathology in families with and without eating disorders. Data are collected from the mother, father, and daughter of 30 families with a daughter diagnosed with anorexia or bulimia and from 30 matched…

Attitudes Regarding HPV Vaccinations of Children among Mothers with Adolescent Daughters in Korea

Science.gov (United States)

2017-01-01

The aim of this study, carried out before the beginning of human papillomavirus (HPV) vaccinations as a National Immunization Program (NIP) in Korea in 2016, is to assess the ranges of perceptions and personal experience and their influences on attitudes regarding HPV vaccinations of children, among mothers of adolescent (9–14 years of age) daughters in Korea. From November 2015 to February 2016, we distributed a written questionnaire to mothers who had daughters aged 9–14 years. The questionnaire consisted of several questions, related to knowledge of HPV, personal experiences of HPV vaccination, and attitudes toward HPV vaccinations of their adolescent daughters. Of the 260 questionnaires distributed, 140 participants returned answered ones. And although only 51% of participants were aware that cervical cancer is highly related with HPV infection, 70% said they were willing to vaccinate their daughters, showing that awareness does not coincide with intention to vaccinate. Among the participants showing negative attitudes, 50% were concerned about the vaccination side effects. The more the participants’ pre-knowledge about HPV infection, and about the relationship of HPV to cervical cancer, the more positive their attitudes (P = 0.002, P vaccinating their adolescent daughters rose as well. Thus, the provision of correct education by health care providers and accurate information through active advertising may play an important role in increasing the vaccination rate among adolescent girls in Korea. PMID:27914142

Radon and radon daughters in South African underground mines

International Nuclear Information System (INIS)

Rolle, R.

1980-01-01

Radon and the radon daughters are the radionuclides which primarily determine the level of the radiation hazard in underground uranium mines and to a smaller extent in non-uranium mines. Radon is a gas, and its daughters adsorb on aerosol particles which are of respirable size. The hazard thus arises from the alpha decay of radon and its daughters in contact with lung tissue. Radon is itself part of the uranium decay chain. The major radionuclide, 238 U, decays successively through thirteen shorter-lived radionuclides to 206 Pb. Radon is the only gaseous decay product at room temperature; the other twelve are solids. The main hazard presented by the uranium decay chain is normally determined by the radon concentration because gaseous transport can bring alpha emitters close to sensitive tissue. There is no such transport route for the other alpha emitters, and the level of beta and gamma radiation caused by the uranium decay chain generally presents a far lower external radiation hazard. Radon itself is the heaviest of the noble gases, which are He, Ne, Ar, Kr, Xe and Rn. Its chemical reactions are of no concern in regard to its potential hazard in mines as it may be considered inert. It does, however, have a solubility ten times higher than oxygen in water, and this can play a significant part in assisting the movement of the gas from the rock into airways. Radon continuously emanates into mine workings from uranium ores and from the uranium present at low concentrations in practically any rock. It has been found that the control of the exposure level is most effectively achieved by sound ventilation practices. In South African mines the standard of ventilation is generally high and exposure to radon and radon daughters is at acceptably low levels

Distinguish natural sources out of secular equilibrium with their parents or daughters in Gamma ray spectrum analyses

International Nuclear Information System (INIS)

Mao Yahong; Liu Yigang

2005-01-01

Objective: To determine materials containing natural radionuclides in or out secular equilibrium with their parents or daughters. Methods: In gamma ray spectrum analyses, the activity concentration of every daughter is the same as that of its parent when the material is in secular equilibrium. The activity concentrations of daughters and their parents are different when the material is out of secular equilibrium. Results: It is different to determine whether the exposures from these materials should be exempted that materials containing natural radionuclides are in or out of secular equilibrium with their parents or daughters. Conclusion: It is important to determine materials containing natural radionuclides in or out secular equilibrium with their parents or daughters in gamma ray spectrum analyses. (authors)

Are you a developer? Let's talk!

CERN Multimedia

CERN. Geneva

2014-01-01

Many of us have to create software as part of our work, if you do probably you asked yourself some of the following: How other people at CERN develop? What technologies have they used? What worked and what didn't for them? Am I reinventing the wheel? What CERN services can make my life easier? What other services I miss that would be useful to have? How can I integrate my system with XXYY at CERN? Unfortunately there is little communication between us and we need to fix that, let's find initiatives to improve and share experiences between software engineers... let's talk!

Methodology and monitoring of radon, thoron and their daughters

International Nuclear Information System (INIS)

Townsend, M.G.

1984-02-01

Methods are described for monitoring radon and thoron gases and their daughter products in occupational and non-occupational environments. Grab-sampling, continuous monitoring, integrated measurements and personal dosimetry are discussed. Errors in different measurement methods are compared. Calibration aspects of measurement techniques are described and procedures for interlaboratory calibration are suggested. An account of unattached fraction and plateout of radon daughters is included. Sampling strategies for occupational and non-occupational environments are discussed and a table of regulations and recommendations for monitoring radiation in countries of the OECD is provided. Radiation protection training requirements are identified. Where sufficient information and consensus of opinion exist, guidelines on apparatus, methods and procedures for monitoring are developed

The radon daughter radiation hazard in controlled recirculation systems

International Nuclear Information System (INIS)

Rolle, R.; Burton, R.C.

1987-01-01

In deep South African gold mines, controlled recirculation systems with air cooling are being used to an increasing extent to improve the thermal environment. Recirculation causes some air to reside in the working area for a longer time than would have occurred without recirculation. Since radon daughters grow spontaneously from radon there is some concern that, with the extended residence time, the potential radiation hazard could increase to an unacceptable level. This paper describes the results obtained from a theoretical model of a controlled recirculation system. Guidelines for the design of recirculation systems to control the radon daughter radiation, and to keep it within acceptable limits are provided. 3 refs., 5 figs

Maternal Pre-pregnancy BMI and Reproductive Health of Daughters in Young Adulthood

DEFF Research Database (Denmark)

Mariansdatter, Saga Elise; Ernst, Andreas; Toft, Gunnar

2016-01-01

Objective To investigate the possible associations between maternal pre-pregnancy body mass index (BMI) and daughters' age of menarche and subsequent markers of reproductive health. Methods Nine hundred eighty-five pregnant women (80 %) were enrolled at their routine 30th week examinations in 1988...... dehydroepiandrosterone-sulphate (DHEAS), estradiol, and free estrogen index (FEI), compared to the middle BMI tertile. This was supported by a sub-analysis using the WHO classification (underweight, BMI obese, BMI ≥ 25.00 kg/m2) as exposure groups, in which daughters...... of overweight mothers had lower levels of DHEAS and estradiol, and lower FEI compared to daughters of normal weight mothers. No associations were found for ovarian follicle count in any of the groups. Conclusions for Practice We found that higher maternal BMI is associated with earlier age of menarche...

LET dependence of scintillation yields in liquid argon

Energy Technology Data Exchange (ETDEWEB)

Doke, Tadayoshi; Hitachi, Akira; Kikuchi, Jun; Crawford, H J; Lindstrom, P J; Masuda, Kimiaki; Shibamura, Eido; Takahashi, Tan

1988-06-01

Scintillation yields (scintillation intensity per unit absorbed energy) in liquid argon for ionizing particles are reviewed as a function of LET for the particles. The maximum scintillation yield, which is obtained for relativistic heavy ions from Ne to La, is about 1.2 times larger than that for gamma rays in NaI(Tl) crystal. In the low LET region, the scintillation yields for relativistic electrons, protons and He ions are 10-20% lower than the maximum yield. This tendency can be explained by taking into account the existence of the electrons which have escaped from their parent ions. In the high LET region, a quenching effect due to high ionization density is observed for alpha particles, fission fragments and relativistic Au ions.

Like daughter, like son? Fertility decline and the transformation of gender systems in the family

Directory of Open Access Journals (Sweden)

Keera Allendorf

2012-10-01

Full Text Available BACKGROUND An important question for population research is whether fertility decline transforms gender systems. OBJECTIVE This paper contributes to answering this broad question by examining how fertility decline may change the relative value and roles of daughters versus sons in families. First, I outline theoretical pathways, suggesting that a key factor is the gender composition of families. As fertility declines, the proportion of families with children of only one gender increases, which may facilitate greater gender symmetry between daughters and sons. Second, I explore how fertility decline may be transforming the relative value and roles of sons and daughters in practice in one place. METHODS The analysis draws primarily on semi-structured interviews with 30 respondents living in one Indian village. RESULTS In recent decades, fertility has declined to at least replacement levels. Respondents also perceive changes in the gender system, including less son preference, more equal schooling for sons and daughters, more freedom in marriage and pre-marital relationships, and perhaps greater daughter support of parents in old age. CONCLUSIONS The results describe changes in the relative value, treatment, and behavior of sons and daughters that are consistent with the theorized effects of fertility decline. Future research is needed, however, to determine whether fertility decline makes a unique causal contribution to changes in the gender system.

Is my daughter still a virgin? Can you, please, check it, doctor?

Science.gov (United States)

Rigon, Sara

2018-01-01

Gender-based violence is a pervasive public health problem, let alone a violation of human rights. The World Health Organization (WHO) has estimated that, overall, 35% of women worldwide have experienced physical and/or sexual intimate partner violence or nonpartner sexual violence. In 2016, the author had the privilege to work with an outstanding group of people that helps sexual and gender-based violence (SGBV) survivors in Port-au-Prince, Haiti. The clinic, run by an international nongovernmental organizations, open walk-in to anyone in need, is functioning to the present day. In its 1 st year along, the clinic helped almost 1000 survivors, mainly underaged girls. At the clinic, a highly qualified staff of local doctors and nurses, psychologists, and social workers is available, free of charge, 24 h a day, 7 days a week, and accessible to SGBV survivors in absolute confidentiality. Survivors are offered all the support they might need as per the WHO guidelines, from medical assistance (treating of physical injuries, testing and preventing sexually transmitted diseases such as HIV or hepatitis B, and also gynecological and obstetric care) to psychological counseling, as well as specific referrals to shelters, legal aid, or secondary care as needed. Virginity still is highly valued in Haiti, and the father, mother, the beau-mare, or aunt of the survivor will often approach the doctor and anxiously whisper the question: "Is my daughter (goddaughter, niece) still a virgin?", "Can you, please, check it, Doctor?" This article presents the perspective of SGBV survivors clinic in Port-au-Prince, Haiti.

Do Parents Discriminate against Their Heavyweight Daughters?

Science.gov (United States)

Crandall, Christian S.

1995-01-01

Attempts to support the parental prejudice hypothesis by having students report on their parents' attitudes. Results from two studies indicate that heavyweight women were more likely to pay their own way through college, irrespective of their parents' income. The selection bias against fat women was strongest for daughters of political…

Culturally-grounded mother-daughter communication-focused intervention for Thai female adolescents.

Science.gov (United States)

Powwattana, Arpaporn; Thammaraksa, Pimrat; Manora, Sroy

2018-02-05

Teenage pregnancy-prevention interventions have fallen short in significantly decreasing risk of pregnancy for Thai populations. The "breaking the voice" ("rak luk khun tong pood") culture-appropriate teenage pregnancy-prevention program was developed using community-based research. Qualitative analyses of focus group data identified salient factors related to sexual communication and behavior. The integration of focus group results with theoretical constructs guided the development of an intervention to reduce risky sexual behavior by increasing communication between mothers and their adolescent daughters. A total of 157 mother-daughter dyads from congested areas in Bangkok participated in pilot testing of the intervention by the use of a survey. The findings indicated a significant increase in the frequency of and number of sexual risk communication (P assertiveness, and ability to decrease sexual risk among daughters (P < .05). "Breaking the voice" represents a female-focused and culturally-relevant intervention to combat teenage pregnancy. © 2018 John Wiley & Sons Australia, Ltd.

"Let's Move" campaign: applying the extended parallel process model.

Science.gov (United States)

Batchelder, Alicia; Matusitz, Jonathan

2014-01-01

This article examines Michelle Obama's health campaign, "Let's Move," through the lens of the extended parallel process model (EPPM). "Let's Move" aims to reduce the childhood obesity epidemic in the United States. Developed by Kim Witte, EPPM rests on the premise that people's attitudes can be changed when fear is exploited as a factor of persuasion. Fear appeals work best (a) when a person feels a concern about the issue or situation, and (b) when he or she believes to have the capability of dealing with that issue or situation. Overall, the analysis found that "Let's Move" is based on past health campaigns that have been successful. An important element of the campaign is the use of fear appeals (as it is postulated by EPPM). For example, part of the campaign's strategies is to explain the severity of the diseases associated with obesity. By looking at the steps of EPPM, readers can also understand the strengths and weaknesses of "Let's Move."

Levels of Rn and its daughters in houses in the northern part of China

International Nuclear Information System (INIS)

Zhang Yulin; Wang Gongpeng; Yu Shui; Wang Yuping; Li Weina.

1993-01-01

In this paper we described the levels of Rn and Rn daughters and their diurnal variation in spring and autumn in 18 typical houses in Harbin, Changchun and Jinxi. The results showed that there was no difference in levels of Rn and Rn daughters inside and outside the new and old houses in spring. The Rn concentration was 7.4∼12.5 Bq m -3 . The level of Rn daughters was 1.0-1.3 mWL. Both of them generally increased in winter and the Rn concentration was 15.1-95.1 Bq m -3 . The potential energy of Rn daughters was 4.6-21.3 mWL. The potential energy of Rn daughters in new houses were 20 and 10 times those in spring in Changchun and Harbin respectively and Rn concentrations were 10 and 4 times those in spring respectively. Rn concentrations in a few houses exceeded 200 Bq m -3 . It was lower from 12:00 to 20:00 and slightly higher from 20:00 to the next morning, and the high concentration peak can be found at morning from 4:00 to 6:00 after 24 hours continuous observation. The results was in agreement with those reported in UNSCEAR 1982 Report

Concern as motivation for protection: an investigation of mothers' concern about daughters' breast cancer risk.

Science.gov (United States)

Neuberger, Lindsay; Silk, Kami J; Yun, Doshik; Bowman, Nicholas David; Anderson, Jennifer

2011-11-01

The present study surveyed mothers with daughters (N = 386) to investigate how mothers' concern about their daughters' breast cancer risk influenced intentions to engage in preventive behaviors. Using protection motivation theory as a framework, self-efficacy, response efficacy, and level of concern were posited to influence protective behavioral intention in distinct ways. Results from regression analyses indicate that self-efficacy, response efficacy, and mothers' concern are significant predictors of intentions to engage in preventive behaviors with daughters. In addition, a content analysis of mothers' open-ended reasons for their concern about their daughters' breast cancer risk yield a list of specific concerns and trends that vary by concern level and individual comment valence. The authors discuss implications for incorporating mothers' concerns into breast cancer prevention messages as a novel strategy for campaign designers.

Attitudes Regarding HPV Vaccinations of Children among Mothers with Adolescent Daughters in Korea.

Science.gov (United States)

Lee, Kyong No; Chang, Kylie Hae Jin; Cho, Seong Sik; Park, Sung Ho; Park, Sung Taek

2017-01-01

The aim of this study, carried out before the beginning of human papillomavirus (HPV) vaccinations as a National Immunization Program (NIP) in Korea in 2016, is to assess the ranges of perceptions and personal experience and their influences on attitudes regarding HPV vaccinations of children, among mothers of adolescent (9-14 years of age) daughters in Korea. From November 2015 to February 2016, we distributed a written questionnaire to mothers who had daughters aged 9-14 years. The questionnaire consisted of several questions, related to knowledge of HPV, personal experiences of HPV vaccination, and attitudes toward HPV vaccinations of their adolescent daughters. Of the 260 questionnaires distributed, 140 participants returned answered ones. And although only 51% of participants were aware that cervical cancer is highly related with HPV infection, 70% said they were willing to vaccinate their daughters, showing that awareness does not coincide with intention to vaccinate. Among the participants showing negative attitudes, 50% were concerned about the vaccination side effects. The more the participants' pre-knowledge about HPV infection, and about the relationship of HPV to cervical cancer, the more positive their attitudes (P = 0.002, P mothers with negative attitudes toward vaccinating their adolescent daughters rose as well. Thus, the provision of correct education by health care providers and accurate information through active advertising may play an important role in increasing the vaccination rate among adolescent girls in Korea.

Ventilation systems as an effective tool for control of radon daughter concentration in mines

International Nuclear Information System (INIS)

Dory, A.B.

1981-10-01

Experience in mines shows that a very high concentration of radon daughters builds up in an unventilated dead end heading. Even minimal air movement results in a drastic reduction in radon daughter concentration. Designing the ventilation system to provide an optimized flow of fresh air into the workplace results in acceptable climatic conditions and radon daughter levels. The example of the Director fluorospar mine in Newfoundland is used to illustrate the actual design and operation of a ventilation system that provided effective radon daughter control. It was found at this mine that the age of the air underground should be kept as low as possible; that no areas of the mine should be left unventilated unless they could be kept at negative pressure; that a comparatively simple remote control and monitoring system helped stabilize ventilation and detected upsets; that the ventilation system should operate continuously, even when the mine is shut down for short periods; and that pressurization of the mine seemed to inhibit radon influx

Mutagenic action of radiation with different LET on Bacillus subtilis cells

International Nuclear Information System (INIS)

edinennyj Inst. Yadernykh Issledovanij, Dubna (Russian Federation))" data-affiliation=" (Obedinennyj Inst. Yadernykh Issledovanij, Dubna (Russian Federation))" >Borejko, A.V.; edinennyj Inst. Yadernykh Issledovanij, Dubna (Russian Federation))" data-affiliation=" (Obedinennyj Inst. Yadernykh Issledovanij, Dubna (Russian Federation))" >Krasavin, E.A.

1997-01-01

The induction of the his - -> his + mutants in vegetative and spores of Bacillus subtilis wild type cells irradiated with γ-rays and helium ions (LET = 20-80 keV/μm) has been investigated. It was shown that the dose dependence of the mutation induction in vegetative cells is described by a linear-quadratic function of dose in case of both γ-rays and helium ions. RBE (LET) dependencies on the lethal and mutagenic effect of radiation have a local maximum. The maximum of RBE (LET) dependence on the mutagenic assay is shifted at the low region of LET in comparison with the lethal effect of irradiation. (author)

The effect of filtration on radon daughter atmospheres: Laboratory and field experiments

International Nuclear Information System (INIS)

Jonassen, N.; Jensen, B.

1987-01-01

Airborne radon daughters may be removed from the air by internal filtration using mechanical or electrofilters. The effect of the filtration may be evaluated in absolute measure by the decrease in the potential alpha energy concentration (or equivalent equilibrium concentration) or relatively by the decrease in the equilibrium factor. The filtration, however, may also change the distribution of airborne radon daughter activity between the unattached and the aerosol-attached state in a way to increase the radiological dose corresponding to a given potential alpha energy concentration. The paper describes a series of laboratory and field experiments which indicate that it is possible by the use of household electrofilters with filtration rates of 2-3 h -1 to lower the radon daughter concentrations to about 20 -30 % and the average radiological dose to about 50-60 % of the value in unfiltered air

Electronic instrument for radon daughter dosimetry. Report of investigations

International Nuclear Information System (INIS)

Durkin, J.

1977-01-01

Due to the daily exposures of uranium mining personnel to 222Rn daughters, a device is needed which will continually monitor the individual's exposure. Such a device has been built and tested and is known as the Radon Daughter Dosimeter. This is an electronic instrument using a solid-state detector and circuitry. The system permits the evaluation of cumulative exposures to airborne radon progeny, expressed in units of Working Level Hours (WL-HRS). The instrument is a personal device worn by the individual throughout the working shift. Since the instrument is in close proximity to the miner and measures continual exposure, it provides an accurate account of total cumulative exposure, thus avoiding the errors caused by the present technique of spot checking of the environment

Parents willingness to pay for a human papillomavirus vaccine to protect their adolescent daughters. Maule Region, Chile.

Directory of Open Access Journals (Sweden)

Arcadio A Cerda

2014-01-01

Full Text Available Objective. To determine the willingness to pay of parents of teenage daughters for a vaccine against human papillomavirus in the Maule Region, Chile. Materials and methods. A sample of 386 parents with daughters between 12 and 18 years old, representing the five largest cities of the Region of Maule, socioeconomically stratified. WTP was obtained using the contingent valuation method in double bounded format. Results. Parents are willing to pay an average of US$ 252.71 to vaccinate their daughters against virus, where the price and number of daughters negatively affects the probability of willingness to pay, and family income positively affects the probability. Conclusion. There is a possibility of using shared funding between the government and the parents of potential daughter to be affected by the human papillomavirus to reduce cervical cancer events.

A computer method for simulating the decay of radon daughters

International Nuclear Information System (INIS)

Hartley, B.M.

1988-01-01

The analytical equations representing the decay of a series of radioactive atoms through a number of daughter products are well known. These equations are for an idealized case in which the expectation value of the number of atoms which decay in a certain time can be represented by a smooth curve. The real curve of the total number of disintegrations from a radioactive species consists of a series of Heaviside step functions, with the steps occurring at the time of the disintegration. The disintegration of radioactive atoms is said to be random but this random behaviour is such that a single species forms an ensemble of which the times of disintegration give a geometric distribution. Numbers which have a geometric distribution can be generated by computer and can be used to simulate the decay of one or more radioactive species. A computer method is described for simulating such decay of radioactive atoms and this method is applied specifically to the decay of the short half life daughters of radon 222 and the emission of alpha particles from polonium 218 and polonium 214. Repeating the simulation of the decay a number of times provides a method for investigating the statistical uncertainty inherent in methods for measurement of exposure to radon daughters. This statistical uncertainty is difficult to investigate analytically since the time of decay of an atom of polonium 218 is not independent of the time of decay of subsequent polonium 214. The method is currently being used to investigate the statistical uncertainties of a number of commonly used methods for the counting of alpha particles from radon daughters and the calculations of exposure

Consumer Products Advertised to Save Energy--Let the Buyer Beware.

Science.gov (United States)

1981-07-24

AD-AL06 653 GENERAL ACCOUNTING OFFICE WASHINGTON DC HUMAN RESOUR--ETC F/G 5/3 CONSUMER PRODUCTS ADVERTISED TO SAVE ENERGY--LET THE BUYER BEWA-ETC...COMPTROLLER GENERAL’S CONSUMER PRODUCTS ADVERTISED REPORT TO THE CONGRESS TO SAVE ENERGY- - LET THE BUYER BEWARE D IG E ST In efforts to reduce energy costs...and comparable, GAO believes that the best ad- vice for consumers is "let the buyer beware." (See p. 42.) F’TC ’S COMMENTS FTC said that GAO

Concordant Patterns of Brain Structure in Mothers with Recurrent Depression and Their Never-Depressed Daughters.

Science.gov (United States)

Foland-Ross, Lara C; Behzadian, Negin; LeMoult, Joelle; Gotlib, Ian H

2016-01-01

A growing body of research has demonstrated that having a mother with a history of major depressive disorder (MDD) is one of the strongest predictors of depression in adolescent offspring. Few studies, however, have assessed neural markers of this increased risk for depression, or examined whether risk-related anomalies in adolescents at maternal risk for depression are related to neural abnormalities in their depressed mothers. We addressed these questions by examining concordance in brain structure in two groups of participants: mothers with a history of depression and their never-depressed daughters, and never-depressed mothers and their never-depressed daughters. We scanned mothers with (remitted; RMD) and without (control; CTL) a history of recurrent episodes of depression and their never-depressed daughters, computed cortical gray matter thickness, and tested whether mothers' thickness predicted daughters' thickness. Both RMD mothers and their high-risk daughters exhibited focal areas of thinner cortical gray matter compared with their CTL/low-risk counterparts. Importantly, the extent of thickness anomalies in RMD mothers predicted analogous abnormalities in their daughters; this pattern was not present in CTL/low-risk dyads. We identified neuroanatomical risk factors that may underlie the intergenerational transmission of risk for MDD. Our findings suggest that there is concordance in brain structure in dyads that is affected by maternal depression, and that the location, direction, and extent of neural anomalies in high-risk offspring mirror those of their recurrent depressed mothers. © 2016 S. Karger AG, Basel.

Comparisons of chewing rhythm, craniomandibular morphology, body mass and height between mothers and their biological daughters.

Science.gov (United States)

Cho, Catherine; Louie, Ke'ale; Maawadh, Ahmed; Gerstner, Geoffrey E

2015-11-01

To study and compare the relationships between mean chewing cycle duration, selected cephalometric variables representing mandibular length, face height, etc., measured in women and in their teenage or young-adult biological daughters. Daughters were recruited from local high schools and the University of Michigan School of Dentistry. Selection criteria included healthy females with full dentition, 1st molar occlusion, no active orthodontics, no medical conditions nor medication use that could interfere with normal masticatory motor function. Mothers had to be biologically related to their daughters. All data were obtained in the School of Dentistry. Measurements obtained from lateral cephalograms included: two "jaw length" measures, condylion-gnathion and gonion-gnathion, and four measures of facial profile including lower anterior face height, and angles sella-nasion-A point (SNA), sella-nasion-B point (SNB) and A point-nasion-B point (ANB). Mean cycle duration was calculated from 60 continuous chewing cycles, where a cycle was defined as the time between two successive maximum jaw openings in the vertical dimension. Other variables included subject height and weight. Linear and logistic regression analyses were used to evaluate the mother-daughter relationships and to study the relationships between cephalometric variables and chewing cycle duration. Height, weight, Co-Gn and Go-Gn were significantly correlated between mother-daughter pairs; however, mean cycle duration was not (r(2)=0.015). Mean cycle duration was positively correlated with ANB and height in mothers, but negatively correlated with Co-Gn in daughters. Chewing rate is not correlated between mothers and daughters in humans. Copyright © 2015 Elsevier Ltd. All rights reserved.

Induction and disappearance of G2 chromatid breaks in lymphocytes after low doses of low LET γ - rays and high LET fast neutrons

International Nuclear Information System (INIS)

Vral, Anne; Thierens, Hubert; Baeyens, Ans; De Ridder, Leo

2001-01-01

In view of the potential importance of the G2 assay for detecting chromosomal radiosensitivity and possible predisposition to cancer the need to elucidate the mechanism underlying the formation of chromatid breaks, observed with the G2 assay after low dose irradiation, has been recognised. In this study we irradiated blood samples of 4 healthy donors with low LET γ-rays and high LET neutrons, which initially produce the same number of dsb but of a different quality. By means of the G2 assay, we determined the number of chromatid breaks induced by γ-rays and neutrons and compared the kinetics of chromatid break rejoining for radiations of different quality. In a first set of experiments a dose-response curve for the formation of chromatid breaks was carried out for γ-rays and neutrons with doses ranging between 0.1 and 0.5 Gy. In a second set of experiments the kinetics of chromatid break formation and disappearance was investigated after a dose of 0.5 Gy using post-irradiation times ranging between 0.5 h and 3.5 h. For the highest dose of 0.5 Gy the number of isochromatid breaks were also scored. No significant differences in the number of chromatid breaks were observed between low LET γ-rays and high LET neutrons for the 4 donors at any of the doses given. The dose response curves for the formation of chromatid breaks are linear for both radiation qualities and RBE values equal to one were obtained. Scoring of isochromatid breaks at the highest dose of 0.5 Gy revealed that high LET neutrons are however more effective at inducing isochromatid breaks (RBE of 6.2). The rejoining experiments further showed that the kinetics of disappearance of chromatid breaks following irradiation with low LET γ-rays or high-LET neutrons are not significantly different. T 1/2 0.92 h for γ-rays and t 1/2 = 0.84 h for neutrons were obtained. In conclusion, our results show that at low doses of radiation the induction as well as the disappearance of G2 chromatid breaks is LET

A simple theory of LET spectra of heavy ion beams

International Nuclear Information System (INIS)

Wilson, J.W.; Townsend, L.W.; Schimmerling, W.; Norbury, J.W.; Wong, M.; Badavi, F.

1985-01-01

The transition of high energy ion beams through extended matter is of considerable interest to the space program as well as radiobiology and medical therapy. The transition is defined in terms of various atomic/molecular and nuclear cross sections in a Boltzmann-like equation. One dimensional solutions are derived herein from which LET spectra are derived for secondary fragments. Such LET spectra are fundamental to the evaluation of beam quality, biological effects, and radiation shield effectiveness. Sensitivity of LET spectral distributions to uncertainty in physical parameters such as the isotopic fragmentation parameters, fragment mass, and absorption cross section is established for a number of ion beams. The main limitation in LET studies is the paucity of both elemental and isotopic fragmentation data. The elemental fragmentation data is more readily available because of its simple experimental procedures. It has been suggested by some that natural abundance ratios should be used with the elemental cross sections but this leads to an order-of-magnitude error in LET spectra in many cases. Very few examples of isotopic fragmentation measurements are available. Although major advances in nuclear fragmentation theory have been made, we must await more extensive isotopic fragmentation experiments for final validation

Father-daughter relationship and the severity of eating disorders.

Science.gov (United States)

Horesh, N; Sommerfeld, E; Wolf, M; Zubery, E; Zalsman, G

2015-01-01

Mother-daughter relationship was the focus of studies on the development of eating disorders (ED) for many years. This study aimed to examine the association between the father-daughter relationship and ED and depressive symptoms. Fifty-three women diagnosed with ED were compared to a psychiatric control group (n=26) and to healthy participants (n=60) regarding their perception of their fathers and the relationship with them. Assessments were done using the Parental Bonding Instrument, the Eating Disorders Questionnaire, the Body Shape Questionnaire, the Eating Attitude Test, and the Beck Depression Inventory as well as narrative-based methods. Fathers' negative attributes were significantly associated with ED and depressive symptom. Two profiles of father-daughter relationship were found, the "caring and benevolent" relationship and the "overprotective and avoidant" one. In the latter, patients displayed significantly higher levels of food-restraint, more concerns about eating and about their body shape and appearance, and higher levels of depression. Negative perception of the father's parenting style as well as the quality of the relationship with him are crucial for the understanding of the development and persistence of ED. Therapeutic programs for ED should focus not only on the relationship with the mother but must also address the relationship with the father. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Evaluation of the performance characteristics of radon and radon-daughter concentration measurement devices under controlled environmental conditions

International Nuclear Information System (INIS)

Pearson, M.D.

1989-04-01

The Technical Measurements Center (TMC) conducted a study to expose 10 radon and 7 radon-daughter concentration measurement devices in the DOE/GJPO Radon/Radon-Daughter Environmental Chamber for a series of 24 controlled-environment tests. The tests evaluated the devices' response to temperature, relative humidity, dew point, condensation-nuclei concentration, radon-daughter/radon equilibrium ratio, and non-uniform radon and radon-daughter concentration. Devices were evaluated for linear response as a function of concentration. In addition to response to environmental parameters, the evaluation included determining the utility of the devices in providing reasonable assurance of compliance with the radon and radon-daughter concentration standards for DOE remedial action programs. This reasonable assurance criterion is based on a coefficient of variation of 25 percent for devices deployed for year-long measurements and a coefficient of variation of 18 percent for devices deployed for intermittent sampling. 39 refs., 65 figs., 33 tabs

Let7a involves in neural stem cell differentiation relating with TLX level

Energy Technology Data Exchange (ETDEWEB)

Song, Juhyun [Department of Anatomy, Yonsei University College of Medicine, Seoul (Korea, Republic of); Cho, Kyoung Joo; Oh, Yumi [Department of Anatomy, Yonsei University College of Medicine, Seoul (Korea, Republic of); BK21 Plus Project for Medical Sciences, and Brain Research Institute, Yonsei University College of Medicine, Seoul (Korea, Republic of); Lee, Jong Eun, E-mail: jelee@yuhs.ac [Department of Anatomy, Yonsei University College of Medicine, Seoul (Korea, Republic of); BK21 Plus Project for Medical Sciences, and Brain Research Institute, Yonsei University College of Medicine, Seoul (Korea, Republic of)

2015-07-10

Neural stem cells (NSCs) have the potential for differentiation into neurons known as a groundbreaking therapeutic solution for central nervous system (CNS) diseases. To resolve the therapeutic efficiency of NSCs, recent researchers have focused on the study on microRNA's role in CNS. Some micro RNAs have been reported significant functions in NSC self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. MicroRNA-Let7a (Let7a) has known as the regulator of diverse cellular mechanisms including cell differentiation and proliferation. In present study, we investigated whether Let7a regulates NSC differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal, proliferation and differentiation. We performed the following experiments: western blot analysis, TaqMan assay, RT-PCR, and immunocytochemistry to confirm the alteration of NSCs. Our data showed that let7a play important roles in controlling NSC fate determination. Thus, manipulating Let-7A and TLX could be a novel strategy to enhance the efficiency of NSC's neuronal differentiation for CNS disorders. - Highlights: • Let7a influences on NSC differentiation and proliferation. • Let7a involves in mainly NSC differentiation rather than proliferation. • Let7a positively regulates the TLX expression.

Let7a involves in neural stem cell differentiation relating with TLX level

International Nuclear Information System (INIS)

Song, Juhyun; Cho, Kyoung Joo; Oh, Yumi; Lee, Jong Eun

2015-01-01

Neural stem cells (NSCs) have the potential for differentiation into neurons known as a groundbreaking therapeutic solution for central nervous system (CNS) diseases. To resolve the therapeutic efficiency of NSCs, recent researchers have focused on the study on microRNA's role in CNS. Some micro RNAs have been reported significant functions in NSC self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. MicroRNA-Let7a (Let7a) has known as the regulator of diverse cellular mechanisms including cell differentiation and proliferation. In present study, we investigated whether Let7a regulates NSC differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal, proliferation and differentiation. We performed the following experiments: western blot analysis, TaqMan assay, RT-PCR, and immunocytochemistry to confirm the alteration of NSCs. Our data showed that let7a play important roles in controlling NSC fate determination. Thus, manipulating Let-7A and TLX could be a novel strategy to enhance the efficiency of NSC's neuronal differentiation for CNS disorders. - Highlights: • Let7a influences on NSC differentiation and proliferation. • Let7a involves in mainly NSC differentiation rather than proliferation. • Let7a positively regulates the TLX expression

Diffusion-kinetic theories for LET effects on the radiolysis of water

International Nuclear Information System (INIS)

Pimblott, S.M.; LaVerne, J.A.

1994-01-01

Diffusion-kinetic methods are used to investigate the effects of incident particle linear energy transfer (LET) on the radiolysis of water and aqueous solutions. Chemically realistic deterministic diffusion-kinetic calculations examining the scavenging capacity dependences of the scavenged yield of e aq - and of OH demonstrate that the scavenged yields are related to the underlying time-dependent kinetics in the absence of the scavenger by a simple Laplace transform relationship. This relationship is also shown to link the effect of an e eq - scavenger on the formation of H 2 with the time dependence of H 2 production in the absence of the scavenger. The simple Laplace relationship does not work well when applied to H 2 O 2 formation in high-LET particle tracks even though such a relationship is valid with low-LET particles. It is found that while the secondary reaction of H 2 O 2 with e aq - can be neglected in low-LET particle radiolysis, it is of considerable significance in the tracks produced by high-LET particles. The increased importance of this reaction with increasing LET is the major reason for the failure of the Laplace relationship for H 2 O 2 . 55 refs., 9 figs., 2 tabs

Irradiation of single cells with individual high-LET particles

International Nuclear Information System (INIS)

Nelson, J.M.; Braby, L.A.

1993-01-01

The dose-limiting normal tissue of concern when irradiating head and neck lesions is often the vascular endothelium within the treatment field. Consequently, the response of capillary endothelial cells exposed to moderate doses of high LET particles is essential for establishing exposure limits for neutron-capture therapy. In an effort to characterize the high-LET radiation biology of cultured endothelial cells, the authors are attempting to measure cellular response to single particles. The single-particle irradiation apparatus, described below, allows them to expose individual cells to known numbers of high-LET particles and follow these cells for extended periods, in order to assess the impact of individual particles on cell growth kinetics. Preliminary cell irradiation experiments have revealed complications related to the smooth and efficient operation of the equipment; these are being resolved. Therefore, the following paragraphs deal primarily with the manner by which high LET particles deposit energy, the requirements for single-cell irradiation, construction and assembly of such apparatus, and testing of experimental procedures, rather than with the radiation biology of endothelial cells

Intra-familial and ethnic effects on attitudinal and perceptual body image: a cohort of South African mother-daughter dyads

Directory of Open Access Journals (Sweden)

Goedecke Julia H

2011-06-01

Full Text Available Abstract Background International studies suggest ethnic differences in obesity prevalence may be due, in part, to differences in body image and body size dissatisfaction between groups. Further, there is evidence to suggest that there is a familial resemblance in body image between mothers and their younger (preadolescent daughters. This research was therefore conducted to specifically identify the extent to which family status (presented as mother-daughter resemblance and ethnicity impact on body image attitudes and perceptions of South African mothers and their pre-adolescent daughters. Methods Mother-daughter dyads (n = 201, 31% black, 37% mixed ancestry and 32% white answered questions regarding their body image perception (the way they saw their body size status, their body image ideals, and body image attitudes (body size dissatisfaction in particular, presented as the Feel-Ideal Difference [FID] index score. Mothers' and daughters' body image results were compared within dyads and across ethnic groups using repeated measures of ANOVA. Results Overall, body image resemblances exist between South African mothers and their pre-adolescent daughters. Mothers and daughters chose similarly weighted silhouettes to represent their body size ideals (p = 0.308, regardless of their ethnicity or body mass index (BMI. The FID index scores were similar between mothers and their daughters only after the confounding effects of maternal BMI were removed (p = 0.685. The silhouettes chosen to represent thinness were also similar between mothers and their daughters (p = 0.960 regardless of ethnicity and maternal BMI. On the other hand, the silhouettes chosen to represent fatness were similar (p = 0.342 between mothers and their daughters, only after the confounding effects of maternal BMI were removed. Lastly, mothers and their daughters chose similarly weighted silhouettes as engendering feelings of beauty, respect and happiness (p = 0.813; p = 0.615 and p

High LET radiation and mechanism of DNA damage repair

International Nuclear Information System (INIS)

Furusawa, Yoshiya

2004-01-01

Clarifying the mechanism of repair from radiation damage gives most important information on radiation effects on cells. Approximately 10% of biological experiments groups in Heavy Ion Medical Accelerator in Chiba (HIMAC) cooperative research group has performed the subject. They gave a lot of new findings on the mechanism, and solved some open questions. The reason to show the peak of relative biological effectiveness RBE at around 100-200 keV/μm causes miss-repair of DNA damage. Sub-lethal damage generated by high linear energy transfer (LET) radiation can be repaired fully. Potentially lethal damages by high-LET radiation also repaired, but the efficiency decreased with the LET, and so on. (author)

Mother Daughter Relationships: From Infancy to Adulthood. Unit for Child Studies Selected Papers Number 15.

Science.gov (United States)

Phillips, Shelley

Topics related to characteristics of mother/daughter relationships in contemporary patriarchal societies are discussed in this seminar paper. The first section describes cases intended to illustrate ways patriarchal social structures limit contemporary mother/daughter relationships, provides a brief historical contrast, and suggests possible…

Factors Associated with Parental Intent not to Circumcise Daughters ...

African Journals Online (AJOL)

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Daughters in Enugu State of Nigeria: An Application of the Theory ... dichotomized into two categories and logistic regression analysis was performed to examine the association between the ..... The impact of perceived cost and rewards.

Molecular analysis of two genes between let-653 and let-56 in the unc-22(IV) region of Caenorhabditis elegans.

Science.gov (United States)

Marra, M A; Prasad, S S; Baillie, D L

1993-01-01

A previous study of genomic organization described the identification of nine potential coding regions in 150 kb of genomic DNA from the unc-22(IV) region of Caenorhabditis elegans. In this study, we focus on the genomic organization of a small interval of 0.1 map unit bordered on the right by unc-22 and on the left by the left-hand breakpoints of the deficiencies sDf9, sDf19 and sDf65. This small interval at present contains a single mutagenically defined locus, the essential gene let-56. The cosmid C11F2 has previously been used to rescue let-56. Therefore, at least some of C11F2 must reside in the interval. In this paper, we report the characterization of two coding elements that reside on C11F2. Analysis of nucleotide sequence data obtained from cDNAs and cosmid subclones revealed that one of the coding elements closely resembles aromatic amino acid decarboxylases from several species. The other of these coding elements was found to closely resemble a human growth factor activatable Na+/H+ antiporter. Paris of oligonucleotide primers, predicted from both coding elements, have been used in PCR experiments to position these coding elements between the left breakpoint of sDf19 and the left breakpoint of sDf65, between the essential genes let-653 and let-56.

Lung dose and lung cancer risk by inhalation of radon daughters

International Nuclear Information System (INIS)

Jacobi, W.

1983-01-01

The inhalation of short-lived radon daughters constitutes the most important occupational radiation exposure in mines, particularly in uranium mines. Among some groups of miners exposed in the past to relatively high radon levels, an excess lung cancer incidence has been observed. In addition to this occupational hazard, the observed radon levels in domestic houses indicate that the inhalation of short-lived radon daughters seems to be the most important component of the radiation exposure of the population from natural sources. For the quantification and judgment of the radiological impact by inhalation of radon daughters in mines as well as in houses, it is necessary to estimate the relationships between the inhaled activity or potential alpha (α) energy of these radionuclides, the dose to target tissues in the lung, and the possible associated lung cancer (LC) risk. It is the purpose of this paper to give a condensed review of our present knowledge in this field and to indicate the main gaps and uncertainties where future research seems necessary

Experimental and calculated LET distributions in the Cosmos-2044 biosatellite orbit

International Nuclear Information System (INIS)

Dudkin, V.E.; Karpov, O.N.; Potapov, Yu.V.; Benton, E.V.; Frank, A.L.; Watts, J.W. Jr.

1992-01-01

During the flight of the Cosmos-2044 biosatellite, joint U.S.S.R.-U.S.A. investigations of different characteristics of cosmic radiation (CR) in the near-Earth environment were carried out. The U.S. dielectric track detectors CR-39 and Soviet BYa- and BR-type nuclear photo-emulsions were used as detectors. The present work shows some results of experimental measurements of linear energy transfer (LET) spectra of CR particles obtained with the use of these detectors, which were placed both inside and outside the satellite. The LET spectra measurement with plastic detectors is composed of two parts: the measurement of galactic cosmic rays (GCR) particles, and of short-range particles. The contributions of these components to the total LET distribution at various thicknesses of the shielding were analyzed and the results of these studies are presented. Calculated LET spectra in the Cosmos-2044 orbit were compared with experimental data. On the basis of experimental and calculated values of the LET spectra, absorbed and equivalent CR doses were calculated. In the shielding range of 1-1.5 g cm -2 , outside the spacecraft, the photo-emulsions yielded 10.3 mrad d -1 and 27.5 mrem d -1 (LET ≥ 2 MeV cm -1 ) while the CR-39 yielded averages of 1.43 mrad d -1 and 13.4 mrem d -1 (LET ≥ 40 MeV cm -1 ). Inside the spacecraft (≥10 g cm -2 ) the photo-emulsions yielded 8.9 mrad d -1 and 14.5 mrem d -1 . (author)

Decommissioning/closeout of Malargue site: measurement of radon daughter

International Nuclear Information System (INIS)

Avila Cadena, Guadalberto

2000-01-01

In Malargue complex there are about 700,000 mt of uranium tailings disposed off during 32 years of operation of the Malargue facility. The objective of the Malargue Site is to undertake the necessary actions to execute remediation programs. A summary of measurements of concentrations of radon daughter taken in different buildings of the city and in the field shows the influence of radon source. The results obtain for concentrations of radon daughter indicate that they do not differ significantly between each others. The environmental remediation of uranium mill tailings at Malargue Site is a requirement of Nuclear Regulatory Authority (NRA) and of the Mendoza province and a commitment to reduce the doses as low as reasonably achievable, social and economic factors being taken into account (ALARA concept). (author)

Preliminary findings radon daughter levels in structures constructed on reclaimed Florida phosphate land

International Nuclear Information System (INIS)

1975-09-01

Preliminary results are reported from a survey of the radon daughter levels in structures in Polk County, Florida, built on reclaimed phosphate tailings containing various amounts of 226 Ra. The structures surveyed consisted primarily of private dwellings although a few office buildings were also surveyed. Track-etch films and TLD air samplers were used to measure the levels of radon daughters within the structures and in structures built on non-phosphate land. Radiation levels were converted to WL units (the working level (WL) unit is defined as the potential α energy from the short-lived daughters of Rn which will produce 1.3 x 10 5 MeV in one liter of air). The highest observed level in any structure was 0.2 WL. Possible health hazards to long-time occupants are discussed

Develop generic equations to determine radon daughters concentrations in air

International Nuclear Information System (INIS)

Shweikani, R.; Jerby, B.

2011-06-01

Measurements of radon daughter concentrations in air are very important to determine the human dose from background radiation. Therefore, many studies tried to find measurements methods depending on many specific parameters such as measurement time, air pumping period and sample volume. In this study a general equations to determine radon daughter's concentrations in air was found using direct samples. The Equations results were closed to the results obtained from other well known methods. Many measurements with different places and various conditions were performed; the results showed that the new equations are able to be used with an error less than 10%, The relative error can be reduced by increasing the pumping rate or measuring high concentration cases.(author)

Association Between Parental HPV Knowledge and Intentions to Have Their Daughters Vaccinated.

Science.gov (United States)

Mansfield, Lisa N; Onsomu, Elijah O; Merwin, Elizabeth; Hall, Naomi M; Harper-Harrison, Alfreda

2018-04-01

Human papillomavirus (HPV) 16 and 18 causes 66% of cervical cancers (Dunne et al., 2014). Vaccination during adolescence can prevent HPV-associated cervical cancers, yet less than half of adolescent girls are vaccinated. This study examined the association between HPV knowledge and parental intentions to vaccinate daughters against HPV. A retrospective, cross-sectional, national data set from the 2006-2007 Health Information National Trends Survey (HINTS) was used. A multivariate multinomial logistic regression analysis was used to estimate the association between intent to vaccinate and HPV knowledge. After controlling for other covariates, parents who were knowledgeable were more likely to intend to have their daughters vaccinated compared with those who were not knowledgeable (adjusted relative risk ratio [aRRR] = 3.96, p = .004). Having HPV knowledge would significantly increase parents' intent for vaccination against the disease for their daughters. Health care providers should integrate HPV-related education for parents within their services, and policymakers should consider requiring HPV vaccination for school attendance.

Quantitative aspects of radon daughter exposure and lung cancer in underground miners

International Nuclear Information System (INIS)

Edling, C.; Axelson, O.

1983-01-01

Epidemiological studies have shown an excessive incidence of lung cancer in miners with exposure to radon daughters. The various risk estimates have ranged from six to 47 excess cases per 10 6 person years and working level month, but the effect of smoking has not been fully evaluated. A group of iron ore miners was studied in an attempt to obtain quantitative information about the risk of lung cancer due to radon and its daughters among smoking and non-smoking miners. The results show a considerable risk for miners to develop lung cancer; even non-smoking miners seem to be at a rather high risk. An additive effect of smoking and exposure to radon daughters is indicated and an estimate of about 30-40 excess cases per 10 6 person years and working level month seems to apply on a life time basis to both smoking and non-smoking miners aged over 50. (author)

High-LET dose-response characteristics by track structure theory of heavy charged particles

International Nuclear Information System (INIS)

Hansen, J.W.; Olsen, K.J.

1981-09-01

The track structure theory developed by Katz and co-workers ascribes the effect of high-LET radiation to the highly inhomogeneous dose distribution due to low energy Δ-rays ejected from the particle track. The theory predicts the effectiveness of high-LET radiation by using the ion parameters zsub(eff') effective charge of the ion, and β = v/c, the relative ion velocity, together with the characteristic dose D 37 derived from low-LET dose-response characteristic of the detector and the approximate size asub(0) of the sensitive element of the detector. 60 Co gamma-irradiation is used as a reference low-LET radiation, while high-LET radiation ranging from 16 MeV protons to 4 MeV/amu 16 0-ions covering an initial LET range of 30-5500 MeVcm 2 /g is obtained from a tandem Van de Graaff accelerator. A thin film (5mg/cm 2 ) radiochromic dye cyanide plastic dosemeter was used as detector with the characteristic dose of 16.8 Mrad and a sensitive element size of 10 -7 cm. Theoretical and experimental effectiveness, RBE, agreed within 10 to 25% depending on LET. (author)

Adolescent Daughters' Romantic Competence: The Role of Divorce, Quality of Parenting, and Maternal Romantic History

Science.gov (United States)

Shulman, Shmuel; Zlotnik, Aynat; Shachar-Shapira, Lital; Connolly, Jennifer; Bohr, Yvonne

2012-01-01

This study examined the links between parental divorce, quality of maternal parenting, spousal relationships and middle adolescent romantic competence in 80 mother-adolescent daughter pairs (40 divorced). Mothers were asked to describe their attitudes and behaviors with regard to their daughters' romantic behavior. In addition, mothers were…

A Healthy Lifestyle Program for Latino Daughters and Mothers: The BOUNCE Overview and Process Evaluation

Science.gov (United States)

Olvera, Norma N.; Knox, Brook; Scherer, Rhonda; Maldonado, Gabriela; Sharma, Shreela V.; Alastuey, Lisa; Bush, Jill A.

2008-01-01

Background: Few family-based healthy lifestyle programs for Latinos have been conducted, especially family programs targeting mother-daughter dyads. Purpose: To assess the acceptability and feasibility of the Behavior Opportunities Uniting Nutrition Counseling and Exercise (BOUNCE) program designed for Latino mother-daughter pairs. Methods: 92…

High-LET charged particle radiotherapy

International Nuclear Information System (INIS)

Castro, J.R.; California Univ., San Francisco, CA

1991-07-01

The Department of Radiation Oncology at UCSF Medical Center and the Radiation Oncology Department at UC Lawrence Berkeley Laboratory have been evaluating the use of high LET charged particle radiotherapy in a Phase 1--2 research trial ongoing since 1979. In this clinical trail, 239 patients have received at least 10 Gy (physical) minimum tumor dose with neon ions, meaning that at least one-half of their total treatment was given with high-LET charged particle therapy. Ninety-one patients received all of their therapy with neon ions. Of the 239 patients irradiated, target sites included lesions in the skin, subcutaneous tissues, head and neck such as paranasal sinuses, nasopharynx and salivary glands (major and minor), skull base and juxtaspinal area, GI tract including esophagus, pancreas and biliary tract, prostate, lung, soft tissue and bone. Analysis of these patients has been carried out with a minimum followup period of 2 years

Carcinogenic effects of radon daughters, uranium ore dust and cigarette smoke in beagle dogs

International Nuclear Information System (INIS)

Cross, F.T.; Palmer, R.F.; Filipy, R.E.; Dagle, G.E.; Stuart, B.O.

1982-01-01

The development of pulmonary lesions in beagle dogs was studied following chronic inhalation exposures to radon (at 105 +- 20 nCi/l), radon daughters (at 605 +- 169 WL), uranium ore dust (at 12.9 +- 6.7 mg/m 3 ) and cigarette smoke. Chronic exposures to mixtures of these agents caused significant lifespan shortening compared with controls. Survival times of controls and smoke-exposed dogs were equivalent during the 4 to 5-yr mean survival time of the dogs exposed to radon-daughter and ore-dust mixtures (with or without added cigarette smoke). Animals with tumors of the respiratory tract generally has cumulative radon-daughter exposures exceeding 13,000 WLM; their survival time was longer than that of nontumor-bearing animals. Exposure to cigarette smoke had a mitigating effect on radon daughter-induced tumors. Exposures to smoke from 10 cigarettes/d, 7 d/wk produced no significant respiratory tract lesions. Exposure to 20 cigarettes/d, 7 d/wk resulted in pulmonary emphysema, fibrosis and chronic bronchitis and bronchiolitis. Emphysema and fibrosis were much more prevalent and severe in the dogs exposed to mixtures including radon daughters and uranium/ore dust. These dogs also had adenomatous lesions which progressed to squamous metaplasia of alveolar epithelium, epidermoid carcinoma and bronchioloalveolar carcinoma. Pathologic changes in the airways of these dogs were most prominent in the nasal mucosa, and included a few squamous carcinomas in the nasal cavity. (author)

Is my daughter still a virgin? Can you, please, check it, doctor?

Directory of Open Access Journals (Sweden)

Sara Rigon

2018-01-01

Full Text Available Gender-based violence is a pervasive public health problem, let alone a violation of human rights. The World Health Organization (WHO has estimated that, overall, 35% of women worldwide have experienced physical and/or sexual intimate partner violence or nonpartner sexual violence. In 2016, the author had the privilege to work with an outstanding group of people that helps sexual and gender-based violence (SGBV survivors in Port-au-Prince, Haiti. The clinic, run by an international nongovernmental organizations, open walk-in to anyone in need, is functioning to the present day. In its 1st year along, the clinic helped almost 1000 survivors, mainly underaged girls. At the clinic, a highly qualified staff of local doctors and nurses, psychologists, and social workers is available, free of charge, 24 h a day, 7 days a week, and accessible to SGBV survivors in absolute confidentiality. Survivors are offered all the support they might need as per the WHO guidelines, from medical assistance (treating of physical injuries, testing and preventing sexually transmitted diseases such as HIV or hepatitis B, and also gynecological and obstetric care to psychological counseling, as well as specific referrals to shelters, legal aid, or secondary care as needed. Virginity still is highly valued in Haiti, and the father, mother, the beau-mare, or aunt of the survivor will often approach the doctor and anxiously whisper the question: “Is my daughter (goddaughter, niece still a virgin?”, “Can you, please, check it, Doctor?” This article presents the perspective of SGBV survivors clinic in Port-au-Prince, Haiti.

Instrumentation for collecting and measuring radon and its daughters

International Nuclear Information System (INIS)

Essling, M.A.; Hengde, W.; Markun, F.; Toohey, R.E.; Rundo, J.; Miranda, J.E. Jr.

1982-01-01

A new sampling can is described for collecting an air sample for determination of its radon content. Instruments which are employed for the continuous monitoring of radon or its daughters in houses are described and their performances discussed

Alpha-particle dosimetry using solid state nuclear track detectors. Application to 222Rn and its daughters

International Nuclear Information System (INIS)

Barillon, R.; Chambaudet, A.

2000-01-01

A methodology for the determination of the detection efficiency of a solid state nuclear track detector for radon and its short-lived daughters was presented. First, particular attention is paid to the α-particles having energies and angles of incidence that lead to observable tracks after an adapted chemical etching. The results are then incorporated in a mathematical model to determine the theoretical radon detection efficiency of a polymeric detector placed in a cylindrical cell. When applied to LR115 and CR39 detectors, the model reveals the influence of the position of the radon daughters inside the cell. Radon daughters tend to link up with natural atmospheric aerosols and then settle on the cell's inside wall. This model allows to determine, among other things, the cell size for which the detector response is independent of the fraction daughters plated out. (author)

The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.

Science.gov (United States)

McDaniel, Kelly; Huang, Li; Sato, Keisaku; Wu, Nan; Annable, Tami; Zhou, Tianhao; Ramos-Lorenzo, Sugeily; Wan, Ying; Huang, Qiaobing; Francis, Heather; Glaser, Shannon; Tsukamoto, Hidekazu; Alpini, Gianfranco; Meng, Fanyin

2017-07-07

The let-7/Lin28 axis is associated with the regulation of key cellular regulatory genes known as microRNAs in various human disorders and cancer development. This study evaluated the role of the let-7/Lin28 axis in regulating a mesenchymal phenotype of hepatic stellate cells in alcoholic liver injury. We identified that ethanol feeding significantly down-regulated several members of the let-7 family in mouse liver, including let-7a and let-7b. Similarly, the treatment of human hepatic stellate cells (HSCs) with lipopolysaccharide (LPS) and transforming growth factor-β (TGF-β) significantly decreased the expressions of let-7a and let-7b. Conversely, overexpression of let-7a and let-7b suppressed the myofibroblastic activation of cultured human HSCs induced by LPS and TGF-β, as evidenced by repressed ACTA2 (α-actin 2), COL1A1 (collagen 1A1), TIMP1 (TIMP metallopeptidase inhibitor 1), and FN1 (fibronectin 1); this supports the notion that HSC activation is controlled by let-7. A combination of bioinformatics, dual-luciferase reporter assay, and Western blot analysis revealed that Lin28B and high-mobility group AT-hook (HMGA2) were the direct targets of let-7a and let-7b. Furthermore, Lin28B deficiency increased the expression of let-7a/let-7b as well as reduced HSC activation and liver fibrosis in mice with alcoholic liver injury. This feedback regulation of let-7 by Lin28B is verified in hepatic stellate cells isolated by laser capture microdissection from the model. The identification of the let-7/Lin28 axis as an important regulator of HSC activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis and novel therapeutic approaches for human alcoholic liver diseases. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Parental smoking during pregnancy and the risk of gestational diabetes in the daughter

DEFF Research Database (Denmark)

Bao, Wei; Michels, Karin B; Tobias, Deirdre K

2016-01-01

BACKGROUND: Fetal exposure to parental smoking may have long-term impact on the development of disease in adulthood. We examined the association of parental smoking during pregnancy with risk of gestational diabetes mellitus (GDM) in the daughter. METHODS: We included 15,665 singleton pregnancies....../day) during pregnancy was associated with higher risk of gestational diabetes in the daughter. Further studies are warranted to confirm our findings and to elucidate the underlying mechanisms....

A law of removing radon by ventilation and air requirement calculation for eliminating radon daughters in uranium mines

International Nuclear Information System (INIS)

Wu Gang

1988-06-01

In accordance with testing data of removing radon and its daughters by ventilation from shrinkage and filling stopes of uranium mines, a law of removing radon by ventilation from the stopes is analyzed and summed. According to the decay law of radon and its daughters, an accumulation equation of potential alpha energy from radon daughters is presented with hyperbolic regression equation. the calculating formulae of ventilation flow are derived from the accumulation equation for eliminating radon daughters in inlet flow with or without contamination. It has been proved that the amount of ventilation air calcuated could meet the requirements of radiation safety rationally and economically

Mutagenic action of radiation with different LET on Bacillus subtilis cells

International Nuclear Information System (INIS)

Borejko, A.V.; Krasavin, E.A.

1996-01-01

The induction of the his - →his + mutants in vegetative and spores of Bacillus subtilis wild type cells irradiated with γ-rays and helium ions (LET=20-80 keV/μm has been investigated. It was shown that the dose dependence of the mutation induction in vegetative cells is described by a linear-quadratic function of dose in case of both γ-rays and helium ions. RBE (LET) dependence on the mutagenic assay is shifted at the low region of LET. (author). 11 refs., 4 figs

The measurement of airborne rodon daughter concentrations in the atmosphere

International Nuclear Information System (INIS)

Ha, C.W.; Lee, J.K.; Moon, P.S.

1979-01-01

A simple method for determining the airborne concentration of radon daughter products has been developed, which is based on gross alpha counting of the air filter collections at several time intervals after completion of air sampling. The concentration of each nuclide is then obtained from an equation involving the alpha disintegrations, the sampling time, and the known numerical coefficients. The state of radioactive disequilibrium is also inventigated. The atmosphere sampled in the TRIGA Mark-III reactor room was largely in disequilibrium. The extent of radioactive disequilibrium between radon daughter products seems likely depend on sampling times associated with turbulence conditions. The data obtained here will certainly provide useful information on the evaluation of internal exposure and calibration of effluent monitoring instruments. (author)

Some measurements of the equilibrium factor for radon daughters in houses

International Nuclear Information System (INIS)

Toohey, R.E.; Essling, M.A.; Wang, H.; Rundo, J.

1982-01-01

Because the radiation dose to the lung from environmental radon is due almost entirely to the inhalation of the short-lived daughter products, measurements of radon levels alone are not sufficient to determine the dose. Typically the activities of the daughter products in air are not in daughters themselves. The working level (WL) was introduced as a convenient unit to overcome this problem in uranium mines, and it is also applicable to other environments where radiation dosimetry is the principal concern. Since it is easier to determine the radon concentration than the working level, the task of determining lung doses would be simplified if those factors which determine equilibrium could be identified and their effects quantified. In order to do this, simultaneous measurements of radon concentrations and working levels must be made in houses under a variety of conditions. In addition, parameters that may affect the equilibrium factor, such as aerosol concentration and ventilation rate, must also be identified and monitored. Although the effects of such parameters may be best determined under controlled conditions in a laboratory, the results must be validated by measurements in houses. This paper describes these measurements

Combined effects of inhalation of Radon daughter products and tobacco smoke

International Nuclear Information System (INIS)

Chameaud, J.; Perraud, R.; Chretien, J.; Masse, R.; Lafuma, J.

1980-01-01

Over the last 10 years, more than 500 lung cancers have been induced in rats by inhalations of radon daughter products at various concentrations and cumulated doses. These cancers were compared with human cancers. Another study examines the cocarcinogenic effect of tobacco smoke. In the first experiment, 100 rats were exposed to a 4000-WLM (working level month) cumulated dose of radon daughter products. Fifty animals were then administered tobacco smoke by inhalation in a fume box during 5 months (i.e., for a total of 352 hr). In the group inhaling radon only, 17 cancers appeared; in the radon-tobacco group, 32 cancers were observed, many of them larger and more invasive than those seen in animals exposed to radon only. Under the same conditions tobacco smoke was inhaled by rats previously exposed to lower doses of radon daughter products (two groups of 30 rats each, at 500 and 100 WLM, respectively). Again, the number of cancers observed was greater than the number of cancers expected if the rats had inhaled radon only. The carcinogenic and potentiating action of tobacco smoke was clearly demonstrated

Fast Neutrons - LET Distributions and the Response of Mammalian Cells

Energy Technology Data Exchange (ETDEWEB)

Bewley, D. K. [Medical Research Council Cyclotron Unit, Hammersmith Hospital, London (United Kingdom)

1968-03-15

Distributions of stopping power (LET) are given for four beams of fast neutrons, namely, neutrons of 14.6 MeV, neutrons produced by bombarding a thick beryllium target with 15 MeV deuterons, neutrons of 3 MeV, and fast neutrons produced by bombardment of a {sup 235}U converter plate with thermal neutrons. The track average LET is correlated with mean neutron energy, but the dose average is approximately constant. However, neither of these types of average is expected to have much relevance to radiobiology. Further, specification of a ''biologically effective LET'' depends on the biological test used, and is not solely a function of the radiation quality. An attempt has been made to calculate the response of T.I. kidney cells in tissue culture to these four beams of neutrons, based on their response to charged particles using the track-segment method. The calculated RBE's of the neutron beams are lower than the observed values and the calculated values of the oxygen enhancement ratio are higher. These differences seem too great to be explained by errors in dosimetry and in the calculated LET spectra. The suggestion is made that LET is not an adequate criterion of radiation quality, and that the discrepancies may be explained by more detailed consideration of the part played by delta rays and by heavy recoil tracks of short range. (author)

Keep it local (and final): Remnant preferences in "let alone" ellipsis.

Science.gov (United States)

Harris, Jesse A; Carlson, Katy

2016-01-01

The let alone construction (John can't run a mile, let alone a marathon) differs from standard coordination structures (with and or but) by requiring ellipsis of the second conjunct--for example, a marathon is the remnant of an elided clause [[see text] a marathon]. In support of an ellipsis account, a corpus study of British and American English finds that let alone exhibits a Locality bias, as the second conjunct preferentially contrasts with the nearest lexical item of the same syntactic type. Two self-paced reading studies show that the Locality bias is active during online processing, but must be reconciled with indicators of semantic contrast and discourse information. Further, a sentence-rating study shows that the Locality bias interacts with a Finality bias that favours placing the let alone phrase at the end of a clause, which sometimes necessitates a nonlocal contrast. Together, the results show how a general bias in ellipsis for local contrasts is affected by discourse demands, such as the need for scalar contrast imposed by let alone, thereby offering a window into how possibly divergent syntactic and discourse constraints impact sentence processing.

High-LET radiation carcinogenesis

International Nuclear Information System (INIS)

Fry, R.J.M.; Powers-Risius, P.; Alpen, E.L.; Ainsworth, E.J.

1985-01-01

The dose-response curves for the induction of tumors by high-LET radiation are complex and are insufficiently understood. There is no model or formulation to describe the dose-response relationship over a range 0 to 100 rad. Evidence suggests that at doses below 20 rad the response is linear, at least for life shortening and some tumor systems. Thus, limiting values of RBEs for the induction of cancer in various tissues can be determined, but it will require sufficient data obtained at low single doses or with small fractions. The results obtained from experiments with heavy ions indicate an initial linear response with a plateauing of the curve at a tumor incidence level that is dependent on the type of tissue. The RBE values for the heavy ions using 60 Co gamma rays as the reference radiation increase with the estimated LET from 4 for 4 H to about 27 for 56 Fe, 40 Ar. The dose-responses and RBEs for 56 Fe and 40 Ar are similar to those for fission neutrons. These findings suggest the possibility that the effectiveness for tumor induction reaches a maximum. 26 refs., 4 figs., 2 tabs

Apoptosis induced by high- and low-LET radiations

International Nuclear Information System (INIS)

Hendry, J.H.; Potten, C.S.; Merritt, A.

1995-01-01

Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals. (orig.)

Generalized concept of the LET-RBE relationship of radiation-induced chromosome aberration and cell death

International Nuclear Information System (INIS)

Takatsuji, Toshihiro; Yoshikawa, Isao; Sasaki, Masao S.

1999-01-01

The frequency of chromosome aberrations per traversal of a nucleus by a charged particle at the low dose limit increases proportionally to the square of the linear energy transfer (LET), peaks at about 100 keV/μm and then decreases with further increase of LET. This has long been interpreted as an excessive energy deposition over the necessary energy required to produce a biologically effective event. Here, we present an alternative interpretation. Cell traversed by a charged particle has certain probability to receive lethal damage leading to direct death. Such events may increase with an increase of LET and the number of charged particles traversing the cell. Assuming that the lethal damage is distributed according to a Poisson distribution, the probability that a cell has no such damage is expressed by e -cLx , where c is a constant, L is LET, and x is the number of charged particles traversing the cell. From these assumptions, the frequency of chromosome aberration in surviving cells can be described by Y=αSD+βS 2 D 2 with the empirical relation Y=αD+βD 2 in the low LET region, where S=e -cL , α is a value proportional to LET, β is a constant, and D is the absorbed dose. This model readily explains the empirically established relationship between LET and relative biological effectiveness (RBE). The model can also be applied to clonogenic survival. If cells can survive and they have neither unstable chromosome aberrations nor other lethal damage, the LET-RBE relationship for clonogenic survival forms a humped curve. The relationship between LET and inactivation cross-section becomes proportional to the square of LET in the low LET region when the frequency of a directly lethal events is sufficiently smaller than unity, and the inactivation cross-section saturates to the cell nucleus cross-sectional area with an increase in LET in the high LET region. (author)

Improvement of date palm plant lets during rooting stage by silver ion

International Nuclear Information System (INIS)

Sharaf, M.M.; Khamis, M.A.; El Bana, A.; Abd El Galeil, L.M.; Zaid, Z.E.

2012-01-01

This study aim to promote growth plant lets of date palm cv. Zaghlool by decreasing ethylene production inside the containers during rooting stage. Data obtained declared that three silver thiosulphate (STS) levels added to one half strength MS rooting medium improved significantly three rooting measurements (rooting percentage; number and length of developed root lets). However, the lightest STS level (0.25 ml/L of 4 mM STS solution) was the superior, while highest one (1.0 ml/L) was the inferior from statistical point of view. Data obtained displayed that providing MS rooting medium with silver nitrate improved 3 rooting measurements (rooting %; number of root lets and their length) for Zaghloul date palm shoot lets proliferated from somatic embryos. However, the 0.50 mg/L AgNO 3 provided MS medium was the most preferable in this concern. Plant lets were transferred to capped tubes contained 1/4 liquid MS medium through 3 weeks in the growth chamber (under aseptic condition). Ventilation was allowed gradually by punching holes in aluminum foil caps during first five days of 2 nd week. After then, the plant lets were transplanted in acclimatization green house on mixture from (peat moss + perlite + vermiculite at 1:1:1) and survival percentage was 75% after three months.

PARP-1 is a key player in controlling apoptosis induced by high LET carbon ion beam and low LET gamma radiation in HeLa cells

International Nuclear Information System (INIS)

Ghorai, Atanu; Ghosh, Utpal; Bhattacharyya, Nitai P.; Sarma, Asitikantha

2014-01-01

PARP-1 inhibitors have long been used as chemo-sensitizer or radio-sensitizer and specific PARP-1 inhibitors are also in clinical trial for the treatment of various cancers. PARP-1 is not only involved in DNA repair but also plays very complex role in induction of apoptosis in postirradiation condition. Our objective is to investigate role of PARP-1 in apoptosis triggered by high LET carbon ion beam (CIB) and low LET gamma. We have treated HeLa and PARP-1 knock down HeLa (Hsil) cells with various doses of CIB and gamma. We measured DNA damage by comet assay and various apoptotic parameters such as nuclear fragmentation, activation of caspase-3,8,9, AIF translocation etc. We observed higher DNA breaks and also higher apoptosis in HsiI cells compared with HeLa cells. Both CIB and gamma treatment results G2/M arrest but unlike gamma CIB makes S-phase delay, implicating that gamma and CIB triggers different pathway after DNA damage. Cell death by CIB or by gamma increased up on knocking down of PARP-1 but increase is higher for high LET CIB compared with low LET gamma. Furthermore, expression level of PARP-1 controls the intensity of overall apoptosis in cells in post-irradiation condition. So, combination of PARP-1 inhibition with high LET CIB could be a promising tool to combat cancer. (author)

Parental smoking during pregnancy and the risk of gestational diabetes in the daughter.

Science.gov (United States)

Bao, Wei; Michels, Karin B; Tobias, Deirdre K; Li, Shanshan; Chavarro, Jorge E; Gaskins, Audrey J; Vaag, Allan A; Hu, Frank B; Zhang, Cuilin

2016-02-01

Fetal exposure to parental smoking may have long-term impact on the development of disease in adulthood. We examined the association of parental smoking during pregnancy with risk of gestational diabetes mellitus (GDM) in the daughter. We included 15,665 singleton pregnancies from 10,152 women in the Nurses' Health Study II cohort whose mothers participated in the Nurses' Mothers' Cohort Study. Data on maternal and paternal smoking during pregnancy and associated covariates were recalled by the mothers. GDM diagnosis was self-reported by the daughters and was validated by medical record review in a previous study. We used log-binomial models with generalized estimating equations to estimate relative risks (RRs) and 95% confidence intervals (CIs). We observed a positive association between maternal heavy smoking during pregnancy and risk of GDM in the daughter. The multivariable-adjusted RRs (95% CIs) of GDM among women whose mothers did not smoke during pregnancy, continued smoking 1-14, 15-24, and ≥ 25 cigarettes/day were 1.00 (reference), 1.05 (0.81-1.35), 1.27 (0.95-1.70) and 1.98 (1.18-3.30), respectively (P for trend = 0.01). Further adjustment for the women's perinatal variables, adult-life characteristics and body mass index during various periods of life modestly attenuated the association. No association was observed between paternal smoking during the pregnancy period and risk of GDM in the daughter. Maternal heavy smoking (≥ 25 cigarettes/day) during pregnancy was associated with higher risk of gestational diabetes in the daughter. Further studies are warranted to confirm our findings and to elucidate the underlying mechanisms. Published by Oxford University Press on behalf of International Epidemiological Association 2016. This work is written by US Government employees and is in the public domain in the US.

Parent heparin and daughter LMW heparin correlation analysis using LC-MS and NMR

Energy Technology Data Exchange (ETDEWEB)

Liu, Xinyue, E-mail: liux22@rpi.edu [National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, State Key Laboratory of Microbial Technology, Shandong University, Jinan, Shandong, 250100 (China); Department of Chemistry and Chemical Biology, Department of Chemical and Biological Engineering, Department of Biology, Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180 (United States); St Ange, Kalib, E-mail: stangk2@rpi.edu [Department of Chemistry and Chemical Biology, Department of Chemical and Biological Engineering, Department of Biology, Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180 (United States); Wang, Xiaohua, E-mail: wangx35@rpi.edu [Department of Chemistry and Chemical Biology, Department of Chemical and Biological Engineering, Department of Biology, Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180 (United States); School of Computer and Information, Hefei University of Technology, Hefei (China); Lin, Lei, E-mail: Linl5@rpi.edu [Department of Chemistry and Chemical Biology, Department of Chemical and Biological Engineering, Department of Biology, Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180 (United States); Zhang, Fuming, E-mail: zhangf2@rpi.edu [Department of Chemistry and Chemical Biology, Department of Chemical and Biological Engineering, Department of Biology, Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180 (United States); and others

2017-04-08

Heparin is a structurally complex, polysaccharide anticoagulant derived from livestock, primarily porcine intestinal tissues. Low molecular weight (LMW) heparins are derived through the controlled partial depolymerization of heparin. Increased manufacturing and regulatory concerns have provided the motivation for the development of more sophisticated analytical methods for determining both their structure and pedigree. A strategy, for the comprehensive comparison of parent heparins and their LMW heparin daughters, is described that relies on the analysis of monosaccharide composition, disaccharide composition, and oligosaccharide composition. Liquid chromatography-mass spectrometry is rapid, robust, and amenable to automated processing and interpretation of both top-down and bottom-up analyses. Nuclear magnetic resonance spectroscopy provides complementary top-down information on the chirality of the uronic acid residues and glucosamine substitution. Principal component analysis (PCA) was applied to the normalized abundance of oligosaccharides, calculated in the bottom-up analysis, to show parent and daughter correlation in oligosaccharide composition. Using these approaches, six pairs of parent heparins and their daughter generic enoxaparins from two different manufacturers were comprehensively analyzed. Enoxaparin is the most widely used LMW heparin and is prepared through controlled chemical β-eliminative cleavage of porcine intestinal heparin. Lovenox{sup ®}, the innovator version of enoxaparin marketed in the US, was analyzed as a reference for the daughter LMW heparins. The results, show similarities between LMW heparins from two different manufacturers with Lovenox{sup ®}, excellent lot-to-lot consistency of products from each manufacturer, and detects a correlation between each parent heparin and daughter LMW heparin. - Highlights: • Low molecular weight heparins prepared from different heparin parents were analyzed. • An integrated analytical

Parent heparin and daughter LMW heparin correlation analysis using LC-MS and NMR

International Nuclear Information System (INIS)

Liu, Xinyue; St Ange, Kalib; Wang, Xiaohua; Lin, Lei; Zhang, Fuming

2017-01-01

Heparin is a structurally complex, polysaccharide anticoagulant derived from livestock, primarily porcine intestinal tissues. Low molecular weight (LMW) heparins are derived through the controlled partial depolymerization of heparin. Increased manufacturing and regulatory concerns have provided the motivation for the development of more sophisticated analytical methods for determining both their structure and pedigree. A strategy, for the comprehensive comparison of parent heparins and their LMW heparin daughters, is described that relies on the analysis of monosaccharide composition, disaccharide composition, and oligosaccharide composition. Liquid chromatography-mass spectrometry is rapid, robust, and amenable to automated processing and interpretation of both top-down and bottom-up analyses. Nuclear magnetic resonance spectroscopy provides complementary top-down information on the chirality of the uronic acid residues and glucosamine substitution. Principal component analysis (PCA) was applied to the normalized abundance of oligosaccharides, calculated in the bottom-up analysis, to show parent and daughter correlation in oligosaccharide composition. Using these approaches, six pairs of parent heparins and their daughter generic enoxaparins from two different manufacturers were comprehensively analyzed. Enoxaparin is the most widely used LMW heparin and is prepared through controlled chemical β-eliminative cleavage of porcine intestinal heparin. Lovenox"®, the innovator version of enoxaparin marketed in the US, was analyzed as a reference for the daughter LMW heparins. The results, show similarities between LMW heparins from two different manufacturers with Lovenox"®, excellent lot-to-lot consistency of products from each manufacturer, and detects a correlation between each parent heparin and daughter LMW heparin. - Highlights: • Low molecular weight heparins prepared from different heparin parents were analyzed. • An integrated analytical approach relied

Improving uptake and engagement with child body image interventions delivered to mothers: Understanding mother and daughter preferences for intervention content.

Science.gov (United States)

Garbett, Kirsty M; Diedrichs, Phillippa C

2016-12-01

Mothers are a key influence on adolescent girls' body image. This study aimed to improve understanding of mothers' and daughters' preferences for content in body image interventions designed to assist mothers to promote positive body image among their daughters. British mother-daughter dyads (N=190) viewed descriptions of five evidence-based influences on body image (family, friends, and relationships; appearance-based teasing; media and celebrities; appearance conversations; body acceptance and care). Mothers and daughters each selected the two most important influences to learn about in these interventions. Overall, both mothers and daughters most frequently opted for family, friends, and relationships and body acceptance and care, whereas media and celebrities was their least preferred topic. While the overall sample of mothers and daughters agreed on preferences, Fisher's exact tests showed that within-dyad agreement was low. Recommendations for improving parent and child engagement with, and effectiveness of, child body image interventions delivered to parents are discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

Radiation-Induced Epigenetic Alterations after Low and High LET Irradiations

Energy Technology Data Exchange (ETDEWEB)

Aypar, Umut; Morgan, William F.; Baulch, Janet E.

2011-02-01

Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding the delayed, non-targeted effects of radiation including radiationinduced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET x-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappa B (NFκB), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. MiRNA shown to be altered in expression level after x-ray irradiation are involved in chromatin remodeling and DNA methylation. Different and higher incidence of epigenetic changes were observed after exposure to low LET x-rays than high LET Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This study also shows that the irradiated cells acquire epigenetic changes even though they are chromosomally stable suggesting that epigenetic aberrations may arise in the cell without initiating RIGI.

Primitive human hematopoietic cells give rise to differentially specified daughter cells upon their initial cell division.

NARCIS (Netherlands)

Giebel, B.; Zhang, T.; Beckmann, J.; Spanholtz, J.; Wernet, P.; Ho, A.; Punzel, M.

2006-01-01

It is often predicted that stem cells divide asymmetrically, creating a daughter cell that maintains the stem-cell capacity, and 1 daughter cell committed to differentiation. While asymmetric stem-cell divisions have been proven to occur in model organisms (eg, in Drosophila), it remains illusive

TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

DEFF Research Database (Denmark)

Pedersen, Rune Troelsgaard; Kruse, Thomas; Nilsson, Jakob

2015-01-01

mitotic entry. In early mitosis, TopBP1 marks sites of and promotes unscheduled DNA synthesis. Moreover, TopBP1 is required for focus formation of the structure-selective nuclease and scaffold protein SLX4 in mitosis. Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise...... temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next cell cycle, showing that TopBP1 acts to reduce transmission of DNA damage to G1 daughter cells. Based on these results, we propose that TopBP1 maintains genome integrity in mitosis by controlling chromatin...

Why do low-income minority parents choose human papillomavirus vaccination for their daughters?

Science.gov (United States)

Perkins, Rebecca B; Pierre-Joseph, Natalie; Marquez, Cecilia; Iloka, Sandra; Clark, Jack A

2010-10-01

To explore low-income minority parents' attitudes, intentions, and actions with regard to human papillomavirus (HPV) vaccination for their daughters. Semistructured interviews were conducted in English and Spanish with parents of girls aged 11-18 who were attending clinic visits in an urban medical center and a community health center. We assessed intention with formal scales, probed parents' attitudes regarding vaccination with open-ended questions, and reviewed medical records to determine vaccination rates. Data were analyzed using descriptive statistics and qualitative methods. Seventy-six parents participated (43% African American, 28% Latino, and 26% Caucasian). Most were mothers, had completed high school, and described themselves as religious; nearly one-half were immigrants. Intention correlated highly with receipt of the vaccine; 91% of parents intended to vaccinate their daughters against HPV, and 89% of the girls received vaccination within 12 months of the interview. Qualitative analysis revealed that most parents focused on the vaccine's potential to prevent cervical cancer. Some parents expressed concerns about unknown side effects and promotion of unsafe sexual practices, but these concerns did not hinder acceptance in most cases. The majority of the low-income minority parents surveyed viewed HPV vaccination as a way to protect their daughters from cancer, and thus chose to vaccinate their daughters. Copyright (c) 2010 Mosby, Inc. All rights reserved.

Stochastic model of radon daughter deposition and clearance in human bronchial airways

International Nuclear Information System (INIS)

Hofmann, W.

1996-01-01

Morphometric measurements of human airway casts have repealed that the human bronchial tree is an asymmetrically dividing network, exhibiting individual variations of airway dimensions within a given airway generation Thus, a statistical correlation exists between the linear dimensions of a given parent airway and those of the asymmetrically dividing daughter branches. This statistical relationship, however, is constrained by correlations among various geometrical parameters. i.e., the human lung is not a fully stochastic system. From a statistical analysis of these morphometric data, the following geometrical parameters could be obtained for each airway generation or bifurcation: (i) probability distributions for diameters and lengths, ratios of parent cross section to the combined cross section of both daughters, ratios of major to minor daughter diameters, and branching angles for major and minor branches; (ii) correlations of diameters and lengths; and (iii) the probability of terminating the bronchial region as a function of both diameter and generation number. Since the original lung morphometry refers to total lung capacity, airway diameters and lengths were scaled down to functional residual capacity. (author)

Potential proteins targeted by let-7f-5p in HeLa cells.

Science.gov (United States)

Wang, Yu; Chen, Xiujuan; Zhang, Yi; Song, Jiandong

2017-07-24

MicroRNAs are a class of small, endogenous, non-coding RNAs mediating posttranscriptional gene silencing. The current authors hypothesized that let-7f-5p is likely involved in cell invasion and proliferation by regulating the expression of target genes. The current study combined let-7f-5p with iTRAQ to assess its effect on gene expression in HeLa cells. Results indicated that 164 proteins were expressed at different levels in HeLa cells overexpressing let-7f-5p and negative controls and that 172 proteins were expressed at different levels in let-7f-5p-silenced HeLa cells and negative controls. Results indicated that let-7f-5p may suppress insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) in HeLa cells.

Using the Theory of Planned Behavior to Predict Mothers' Intentions to Vaccinate Their Daughters against HPV

Science.gov (United States)

Askelson, Natoshia M.; Campo, Shelly; Lowe, John B.; Smith, Sandi; Dennis, Leslie K.; Andsager, Julie

2010-01-01

This study assessed mothers' intentions to vaccinate their daughters against human papillomavirus (HPV) using the theory of planned behavior (TPB). Experience with sexually transmitted infections (STIs), beliefs about the vaccine encouraging sexual activity, and perception of daughters' risk for HPV were also examined for a relationship with…

Let us fish4tomorrow

OpenAIRE

J.D., Farrugia

2015-01-01

All over the world, governments and stakeholders are trying to cope with overfishing. Overfishing is when too much fish is caught which leads to an overall degradation of the marine ecosystem. It is the non-sustainable use of ocean resources. http://www.um.edu.mt/think/let-us-fish4tomorrow/

A retrospective study of radon daughter concentrations in the workplace in the fluorspar mines of St. Lawrence, Newfoundland

International Nuclear Information System (INIS)

Corkhill, D.A.; Dory, A.B.

1984-07-01

Fluorspar mining began in St. Lawrence, Newfoundland in the early thirties. In the early years the existing economic and social conditions resulted in poor health and safety practices in the mines. A high incidence of many types of pulmonary diseases, including lung cancer, among the miners was investigated by the Department of National Health and Welfare, and by 1960 radiation in the mines was recognized as the major cause. The original epidemiological study used radon daughter exposure estimates determined from a limited number of radon daughter measurements in one of the mines. Insufficient experience existed at that time to allow a proper technical assessment of the mines and to modify the estimated radon daughter concentrations accordingly. A review of the environmental conditions in the early years of mining and a revision of the estimates of radon daughter concentrations in those mines is presented. Environmental working conditions were determined based on a review of maps, inspectors' reports, Commission hearings, recollections of former workers and of the authors. Comparison to the conditions in the mines in later years, when radiation samples were taken more frequently allowed estimations of the probable radon daughter concentrations that would have existed in the mines earlier. Ranges of estimated average concentrations were made by mines for each year and wherever possible for broad types of job classes. Rather than attempting to propose single numbers for radon daughter concentrations, which in turn might have implied an accuracy that did not exist, ranges of average radon daughter concentrations were estimated

Development of lesions in Syrian golden hamsters following exposure to radon daughters and uranium ore dust

International Nuclear Information System (INIS)

Cross, F.T.; Palmer, R.F.; Busch, R.H.; Filipy, R.E.; Stuart, B.O.

1981-01-01

The development of lesions in Syrian Golden hamsters was studied following life-span inhalation exposures to radon, radon daughters and uranium ore dust. Clinical measurements revealed that life-span exposures to radon daughters and uranium ore dust, singly or in combination, caused no significant changes in mortality patterns, body weights or hematological parameters compared with controls. Pulmonary and nonpulmonary lesions are presented. Exposure to uranium ore dust provoked inflammatory and proliferative responses in the lungs consisting of macrophage accumulation, alveolar cell hyperplasia, and adenomatous alteration of alveolar epithelium. The adenomatous lesions did not undergo further morphologic change. Exposure to radon and radon daughters was associated with increased occurrence of bronchiolar epithelial hyperplasia and with metaplastic changes of alveolar epithelium. Squamous carcinoma developed in only a few hamsters and only in those animals receiving radon daughter exposures exceeding 8000 WLM. It is concluded that an animal model other than the hamster would be more appropriate for study of the pulmonary carcinogenic potential of uranium ore alone. (author)

Influence of various room parameters upon radon daughter equilibrium indoors

International Nuclear Information System (INIS)

Islam, G.S.; Mazumdar, S.C.; Ashraf, M.A.

1995-06-01

The parameters such as ventilation rate, attachment rate to aerosols and deposition processes, which influence the radon daughter equilibrium indoors, are discussed and the validity of the theoretical model checked by experiments. In agreement with the model calculations, the experimental data show, that the equilibrium factor F in rooms is mainly influenced by the rate of attachment to aerosols and the plateout of radon daughters. The equilibrium factor varies between 0.3 and 0.4 at an attachment rate of 300 h -1 . The influence of ventilation upon the free fraction of RaA( 218 Pp)-atoms is also investigated. This is in good agreement with the results of the measurements carried out in different types of rooms at the University Campus of Rajshahi. (author). 20 refs, 3 figs, 3 tabs

Dissident Daughters? The Psychic Life of Class Inheritance

Science.gov (United States)

Hey, Valerie; George, Rosalyn

2013-01-01

This paper arose through a chance meeting between the two authors who are feminist mothers of teenage and 20 years plus daughters. We were attending an Economic and Social Research Council-funded seminar focusing on "new femininities" in the light of post-feminism and their worth and currency within the new politics of consumption and lifestyle.…

Engaging Fathers to Increase Physical Activity in Girls: The "Dads And Daughters Exercising and Empowered" (DADEE) Randomized Controlled Trial.

Science.gov (United States)

Morgan, Philip J; Young, Myles D; Barnes, Alyce T; Eather, Narelle; Pollock, Emma R; Lubans, David R

2018-04-10

Existing strategies to increase girls' physical activity levels have seen limited success. Fathers may influence their children's physical activity, but often spend more time with their sons and rarely participate in family-based programs. To test a novel program designed to increase the physical activity levels of fathers and their daughters. In a two-arm RCT, 115 fathers (29-53 years) and 153 daughters (4-12 years) were randomized to (i) the "Dads And Daughters Exercising and Empowered" (DADEE) program, or (ii) a wait-list control. The 8-week program included weekly educational and practical sessions plus home tasks. Assessments were at baseline, 2 months (postintervention), and 9 months. The primary outcomes were father-daughter physical activity levels (pedometry). Secondary outcomes included screen-time, daughters' fundamental movement skill proficiency (FMS: perceived and objective), and fathers' physical activity parenting practices. Primary outcome data were obtained from 88% of daughters and 90% of fathers at 9 months. Intention-to-treat analyses revealed favorable group-by-time effects for physical activity in daughters (p = .02, d = 0.4) and fathers (p competence (objective: d = 1.1-1.2; perceived: d = 0.4-0.6), a range of fathers' physical activity parenting practices (d = 0.3-0.8), and screen-time for daughters (d = 0.5-0.8) and fathers (d = 0.4-0.6, postintervention only). Program satisfaction and attendance were very high. This study provided the first experimental evidence that efforts to increase physical activity behavior in preadolescent girls would benefit from a meaningful engagement of fathers. Clinical Trial information: Australian New Zealand Clinical Trials Registry: ACTRN12615000022561.

Having a son or daughter with Down syndrome: perspectives from mothers and fathers.

Science.gov (United States)

Skotko, Brian G; Levine, Susan P; Goldstein, Richard

2011-10-01

This study asks parents who have children with Down syndrome (DS) how they feel about their lives so that such information could be shared with expectant couples during prenatal counseling sessions. A valid and reliable survey instrument was mailed to 4,924 households on the mailing lists of six non-profit DS organizations. Of the 2,044 respondents, 99% reported that they love their son or daughter; 97% were proud of them; 79% felt their outlook on life was more positive because of them; 5% felt embarrassed by them; and 4% regretted having them. The parents report that 95% of their sons or daughters without DS have good relationships with their siblings with DS. The overwhelming majority of parents surveyed report that they are happy with their decision to have their child with DS and indicate that their sons and daughters are great sources of love and pride. Copyright © 2011 Wiley-Liss, Inc.

A mother with variant Turner syndrome and two daughters with ...

Indian Academy of Sciences (India)

... and two daughters with trisomy X: a case report ... has been reported, spontaneous pregnancy is rare with risk ... phenotype and includes learning disabilities, speech delays, .... X arise in maternal meiosis make this explanation less likely.

Present practices of the Department of National Health and Welfare for the area monitoring of radon and daughter products

International Nuclear Information System (INIS)

Taniguchi, H.

1977-01-01

The present practices of the Radiation Protection Bureau for the measurement of radon and daughter products have been briefly described. For radon gas, the Lucas chamber method is in use. Short-lived radon daughter products are determined by the modified Kusnetz method. These field methods are supported by radioanalytical procedures carried out at the environmental radioactivity laboratory. Some recent studies using these methods have been briefly summarized. Concentrations of daughter products up to 29 WL were found in a columbium mine and 63 WL in a tin mine under development. The level of radon daughters in some homes in a uranium mining community ranged up to 2 WL

Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction.

Directory of Open Access Journals (Sweden)

Manoj K Mishra

Full Text Available Duchenne muscular dystrophy (DMD is a fatal genetic disease caused by an absence of the 427kD muscle-specific dystrophin isoform. Utrophin is the autosomal homolog of dystrophin and when overexpressed, can compensate for the absence of dystrophin and rescue the dystrophic phenotype of the mdx mouse model of DMD. Utrophin is subject to miRNA mediated repression by several miRNAs including let-7c. Inhibition of utrophin: let-7c interaction is predicted to 'repress the repression' and increase utrophin expression. We developed and tested the ability of an oligonucleotide, composed of 2'-O-methyl modified bases on a phosphorothioate backbone, to anneal to the utrophin 3'UTR and prevent let-7c miRNA binding, thereby upregulating utrophin expression and improving the dystrophic phenotype in vivo. Suppression of utrophin: let-7c interaction using bi-weekly intraperitoneal injections of let7 site blocking oligonucleotides (SBOs for 1 month in the mdx mouse model for DMD, led to increased utrophin expression along with improved muscle histology, decreased fibrosis and increased specific force. The functional improvement of dystrophic muscle achieved using let7-SBOs suggests a novel utrophin upregulation-based therapeutic strategy for DMD.

The determination of a continuous radon daughter equilibrium factor in an operating uranium mine

International Nuclear Information System (INIS)

Billingsley, D.

1992-01-01

Radon daughter exposures to workers at the Olympic Dam Operations copper and uranium mine are calculated from a series of grab samples obtained from various work locations around the mine. Currently under consideration is the introduction of personal passive radon dosimeters to determine the workers' radon daughter exposures. The study reported in this paper involved the determination of long-term equilibrium factors using real-time monitoring of radon and radon daughters. Consequently, variation in equilibrium factor for different tasks can be identified. In practice, the equilibrium factor varies with location and task; however, a conservative over-estimate of 0.28 can be confidently applied to all tasks. The error due to over-estimation remains minimal for all workers. This real-time monitoring method will reduce potential errors in dose assessment compared with the grab sampling technique. 5 refs., 1 tab., 4 figs

Radon: current challenges in cellular radiobiology

International Nuclear Information System (INIS)

Brenner, D.J.

1992-01-01

Most of what is known about the hazards of radon daughters comes from epidemiological studies of miners. There are a few well defined areas in which in vitro research can complement such studies: More data on the relative effects of differing energy (LET) α-particles would help: (1) understand the significance of the depth of sensitive cells in the bronchial epithelium-which varies between individuals, as well as between smokers and non-smokers, and between miners and non-miners; (2) understand the relative hazards of radon and thoron daughters. Reliable methods for predicting high LET responses from low LET response, would enable Japanese A-bomb survivor data to be applied with confidence. Understanding the effects of single-particle traversals of cells relative to multiple traversals could allow reliable extrapolation of epidemiological miner data to low exposures. A better understanding of the nature of the interaction between tobacco and radiation damage would help predict the effect of radon on non-smokers. (author)

Transport of short lived radioactive contaminants with prologed half-lives of daughters through river water

International Nuclear Information System (INIS)

Metwally, S.M.; Prohl, G.

2005-01-01

One of the main pathways for transporting contaminants to other parts in the environment, are rivers. This work is devoted for deriving and assessment the concentration of soluble radio contaminants along a river at any time after discharge, including the short-lived radionuclides in comparison with the discharge time interval, and prolonged half-life of the produced daughter nuclei. The assumed boundary conditions and deduced formulas can be applied either in case of accidental release or discharge under authority control. The formulas determining the produced daughter nuclei concentration require inequality of the parent and daughter nuclei half-lives. Because of the regional variation of river morphology, the assumed constancy of the flow velocity and dispersion coefficient requires dividing the river path into zones of similar hydrologic characteristics

Development of diffusion-based radon daughter dosimeters

International Nuclear Information System (INIS)

Phillips, C.R.; Khan, A.; Leung, H.

1983-07-01

The objective of this work is to investigate the possible application of the mechanisms of thermophoresis and electrostatic collection via electrets to the collection of radon daughters with reference to personal alpha dosimeters for use in uranium mines. The potential advantage accruing from adoption of either one of these collection mechanisms is that collection is passive and does not depend upon the use of a pump (active), and is, therefore, intrinsically much more reliable

Construction of radon/radon daughter calibraton chamber

International Nuclear Information System (INIS)

Fry, J.; Gan, T.H.; Leach, V.A.; Saddlier, J.; Solomon, S.B.; Tam, K.K.; Travis, E.; Wykes, P.

1983-01-01

The radon/radon daughter test chamber is a copper lined room 1.65x1.75x2.75m with an effective volume of 8000 litres. The air residence time is controlled by circulating the air in the chamber through absolute filters which remove 99.9% of particulates. Radon is drawn into the chamber from a 17 μCi 226 RaCl source using the pressure differential across the blowers (<3 psi)

LIN28 expression in malignant germ cell tumors down-regulates let-7 and increases oncogene levels

Science.gov (United States)

Murray, Matthew J.; Saini, Harpreet K.; Siegler, Charlotte A.; Hanning, Jennifer E.; Barker, Emily M.; van Dongen, Stijn; Ward, Dawn M.; Raby, Katie L.; Groves, Ian J.; Scarpini, Cinzia G.; Pett, Mark R.; Thornton, Claire M.; Enright, Anton J.; Nicholson, James C.; Coleman, Nicholas

2013-01-01

Despite their clinico-pathologic heterogeneity, malignant germ-cell-tumors (GCTs) share molecular abnormalities that are likely to be functionally important. In this study, we investigated the potential significance of down-regulation of the let-7 family of tumor-suppressor microRNAs in malignant-GCTs. Microarray results from pediatric and adult samples (n=45) showed that LIN28, the negative-regulator of let-7 biogenesis, was abundant in malignant-GCTs, regardless of patient age, tumor site or histologic subtype. Indeed, a strong negative-correlation existed between LIN28 and let-7 levels in specimens with matched datasets. Low let-7 levels were biologically significant, since the sequence complementary to the 2-7nt common let-7 seed ‘GAGGUA’ was enriched in the 3′untranslated regions of mRNAs up-regulated in pediatric and adult malignant-GCTs, compared with normal gonads (a mixture of germ cells and somatic cells). We identified 27 mRNA targets of let-7 that were up-regulated in malignant-GCT cells, confirming significant negative-correlations with let-7 levels. Among 16 mRNAs examined in a largely independent set of specimens by qRT-PCR, we defined negative-associations with let-7e levels for six oncogenes, including MYCN, AURKB, CCNF, RRM2, MKI67 and C12orf5 (when including normal control tissues). Importantly, LIN28 depletion in malignant-GCT cells restored let-7 levels and repressed all of these oncogenic let-7 mRNA targets, with LIN28 levels correlating with cell proliferation and MYCN levels. Conversely, ectopic expression of let-7e was sufficient to reduce proliferation and down-regulate MYCN, AURKB and LIN28, the latter via a double-negative feedback loop. We concluded that the LIN28/let-7 pathway has a critical pathobiological role in malignant-GCTs and therefore offers a promising target for therapeutic intervention. PMID:23774216

Factors associated with parental intent not to circumcise daughters ...

African Journals Online (AJOL)

This study explored intention of parents not to circumcise daughters in Enugu State, Nigeria using theory of planned behavior (TPB) as a framework. A survey of 1345 parents was carried out using structured questionnaire with FGM question items based on TPB constructs of attitude, subjective norm (SN), perceived ...

Time for "The Talk"... Now What? Autonomy Support and Structure in Mother-Daughter Conversations about Sex

Science.gov (United States)

Mauras, Carrie P.; Grolnick, Wendy S.; Friendly, Rachel W.

2013-01-01

This study explored how mothers communicated with their young adolescent daughters about the high-stakes topic of sex, as well as more everyday topics, from a Self-Determination Theory perspective. Mothers and their 11- to 14-year-old daughters (44 dyads) participated in two conversations and reported on their experiences. In the everyday…

Positioning of the NOR-bearing chromosomes in relation to nucleoli in daughter cells after mitosis.

Science.gov (United States)

Kalmárová, M; Smirnov, E; Kovácik, L; Popov, A; Raska, I

2008-01-01

It is known that chromosomes occupy non-random positions in the cell nucleus. However, it is not clear to what extent their nuclear positions, together with their neighborhood, are conserved in daughter cells. To address specific aspects of this problem, we used the model of the chromosomes carrying ribosomal genes that are organized in clusters termed Nucleolus Organizer Regions (NORs). We compared the association of chosen NOR-bearing chromosomes (NOR-chromosomes) with nucleoli, as well as the numbers of nucleoli, in the pairs of daughter cells, and established how frequently the daughter cells had equal numbers of the homologs of certain NOR-chromosomes associated with individual nucleoli. The daughter cells typically had different numbers of nucleoli. At the same time, using immuno-FISH with probes for chromosomes 14 and 15 in HeLa cells, we found that the cell pairs with identical combinations appeared significantly more frequently than predicted by the random model. Thus, although the total number of chromosomes associated with nucleoli is variable, our data indicate that the position of the NOR-bearing chromosomes in relation to nucleoli is partly conserved through mitosis.

MicroRNAs let-7b/i suppress human glioma cell invasion and migration by targeting IKBKE directly

Energy Technology Data Exchange (ETDEWEB)

Tian, Yuan; Hao, Shaobo [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China); Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052 (China); Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government (China); Ye, Minhua [Department of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006 (China); Zhang, Anling [Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052 (China); Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government (China); Nan, Yang [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China); Wang, Guangxiu; Jia, Zhifan [Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052 (China); Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government (China); Yu, Kai; Guo, Lianmei [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China); Pu, Peiyu [Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052 (China); Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government (China); Huang, Qiang, E-mail: huangqiang209@163.com [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China); Zhong, Yue, E-mail: zhongyue2457@sina.com [Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052 (China)

2015-03-06

We demonstrated that IKBKE is overexpressed in human gliomas and that the downregulation of IKBKE markedly inhibits the proliferative and invasive abilities of glioma cells, which is consistent with the results reported by several different research groups. Therefore, IKBKE represents a promising therapeutic target for the treatment of glioma. In the present study, we verified that the microRNAs let-7b and let-7i target IKBKE through luciferase assays and found that let-7b/i mimics can knock down IKBKE and upregulate E-cadherin through western blot analysis. Moreover, the expression levels of let-7b/i were significantly lower in glioma cell lines than that in normal brain tissues, as determined by quantitative real-time PCR. Furthermore, let-7b/i inhibit the invasion and migration of glioma cells, as determined through wound healing and Transwell assays. The above-mentioned data suggest that let-7b/i inhibit the invasive ability of glioma cells by directly downregulating IKBKE and indirectly upregulating E-cadherin. - Highlights: • Let-7b and let-7i are downregulated in glioma cell lines. • IKBKE is a target gene of let-7b/i. • Let-7b/i inhibit the invasion and migration of glioma cells. • Let-7b/i upregulate E-cadherin by downregulating IKBKE.

MicroRNAs let-7b/i suppress human glioma cell invasion and migration by targeting IKBKE directly

International Nuclear Information System (INIS)

Tian, Yuan; Hao, Shaobo; Ye, Minhua; Zhang, Anling; Nan, Yang; Wang, Guangxiu; Jia, Zhifan; Yu, Kai; Guo, Lianmei; Pu, Peiyu; Huang, Qiang; Zhong, Yue

2015-01-01

We demonstrated that IKBKE is overexpressed in human gliomas and that the downregulation of IKBKE markedly inhibits the proliferative and invasive abilities of glioma cells, which is consistent with the results reported by several different research groups. Therefore, IKBKE represents a promising therapeutic target for the treatment of glioma. In the present study, we verified that the microRNAs let-7b and let-7i target IKBKE through luciferase assays and found that let-7b/i mimics can knock down IKBKE and upregulate E-cadherin through western blot analysis. Moreover, the expression levels of let-7b/i were significantly lower in glioma cell lines than that in normal brain tissues, as determined by quantitative real-time PCR. Furthermore, let-7b/i inhibit the invasion and migration of glioma cells, as determined through wound healing and Transwell assays. The above-mentioned data suggest that let-7b/i inhibit the invasive ability of glioma cells by directly downregulating IKBKE and indirectly upregulating E-cadherin. - Highlights: • Let-7b and let-7i are downregulated in glioma cell lines. • IKBKE is a target gene of let-7b/i. • Let-7b/i inhibit the invasion and migration of glioma cells. • Let-7b/i upregulate E-cadherin by downregulating IKBKE

LET-effects in DNA

International Nuclear Information System (INIS)

Kraft, G.; Taucher-Scholz, G.; Heilmann, J.

1994-11-01

In this contribution, an introductory view on the physical properties of ions is given and the cellular response to high LET radiation is summarized. Then the measurements of strand break induction of DNA in solution and in intracellular DNA are reported and compared to cell survival. The possibility of changes in the quality of the lesions is discussed and finally the present status of model calculations in comparison to the experiments is given. (orig./HSI)

14 CFR 151.47 - Performance of construction work: Letting of contracts.

Science.gov (United States)

2010-01-01

... Development Projects § 151.47 Performance of construction work: Letting of contracts. (a) Advertising required... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Performance of construction work: Letting... project, each contract for construction work on a project in the amount of more than $2,000 must be...

Don't Let Osteoporosis Slow You Down | NIH MedlinePlus the Magazine

Science.gov (United States)

... has never let anything stop her from doing what she loves, and she wasn't about to let osteoporosis keep her off the dance floor. It's that kind of spirit that led the National Osteoporosis Foundation (NOF) to ...

Keep it local (and final): Remnant preferences in ‘let alone’ ellipsis

Science.gov (United States)

Harris, Jesse A.; Carlson, Katy

2015-01-01

The let alone construction (John can't run a mile, let alone a marathon) differs from standard coordination structures (with and or but) by requiring ellipsis of the second conjunct, e.g., a marathon is the remnant of an elided clause [John run a marathon]. In support of an ellipsis account, a corpus study of British and American English finds that let alone exhibits a Locality bias, as the second conjunct preferentially contrasts with the nearest lexical item of the same syntactic type. Two self-paced reading studies show that the Locality bias is active during online processing, but must be reconciled with indicators of semantic contrast and discourse information. Further, a sentence-rating study shows that the Locality bias interacts with a Finality bias that favors placing the let alone phrase at the end of a clause, which sometimes necessitates a non-local contrast. Together, the results show how a general bias in ellipsis for local contrasts is affected by discourse demands, such as the need for scalar contrast imposed by let alone, thereby offering a window into how possibly divergent syntactic and discourse constraints impact sentence processing. PMID:26085004

Radiation-induced epigenetic alterations after low and high LET irradiations

International Nuclear Information System (INIS)

Aypar, Umut; Morgan, William F.; Baulch, Janet E.

2011-01-01

Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding radiation-induced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET X-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappa B (NFκB), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. We demonstrate that miRNA expression levels can be altered after X-ray irradiation and that these miRNA are involved in chromatin remodeling and DNA methylation. A higher incidence of epigenetic changes was observed after exposure to X-rays than Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This distinction is apparent at miRNA analyses at which only three miRNA involved in two major pathways were altered after high LET irradiations while six miRNA involved in five major pathways were altered after low LET irradiations. This study also shows that the irradiated cells acquire epigenetic changes suggesting that epigenetic aberrations may arise in the

Radiation-induced epigenetic alterations after low and high LET irradiations

Energy Technology Data Exchange (ETDEWEB)

Aypar, Umut, E-mail: uaypa001@umaryland.edu [Department of Radiation Oncology, Radiation Oncology Research Laboratory, University of Maryland School of Medicine, Baltimore, MD 21201 (United States); Morgan, William F. [Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352 (United States); Baulch, Janet E. [Department of Radiation Oncology, Radiation Oncology Research Laboratory, University of Maryland School of Medicine, Baltimore, MD 21201 (United States)

2011-02-10

Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding radiation-induced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET X-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappa B (NF{kappa}B), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. We demonstrate that miRNA expression levels can be altered after X-ray irradiation and that these miRNA are involved in chromatin remodeling and DNA methylation. A higher incidence of epigenetic changes was observed after exposure to X-rays than Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This distinction is apparent at miRNA analyses at which only three miRNA involved in two major pathways were altered after high LET irradiations while six miRNA involved in five major pathways were altered after low LET irradiations. This study also shows that the irradiated cells acquire epigenetic changes suggesting that epigenetic aberrations may arise

Tracing and dealing with dwellings with high radon and radon daughter concentrations

International Nuclear Information System (INIS)

Ehdwall, Hans

1980-01-01

In the late 1970s it was found that a number of buildings in Sweden, primarily those made from alum shale-based concretes, had elevated radon and radon daughter levels. A special commission investigated the problem and established provisional limiting values for radon daughter exposures, gamma radiation from the ground, and the concentrations of radioactive materials in building materials. With regard to gamma radiation from the ground the commission proposed that no building be built in an area where outside gamma radiation exceeds 100 μR/h. For building materials a gamma index (mγ) and a radium index (mRa) are suggested: mγ = Csub(K)/10000 + Csub(Ra)/1000 + Csub(Th)/700; mRa = Csub(Ra)/200 (Csub(K), Csub(Ra) and Csub(Th) are the concentrations of potassium, radium and thorium respectively). The proposed limiting values are such that the gamma index and the radium index be less than 1. It is also suggested that action should be taken to reduce radon levels in buildings with radon daughter concentrations of 0.27 WL within two years and 0.10 WL within 5 years

Maternal recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter

Science.gov (United States)

Stuebe, Alison M.; Forman, Michele R.; Michels, Karin B.

2009-01-01

Objective Emerging evidence suggests that exposures during fetal life affect adult metabolism. We assessed the relation between recalled maternal pre-pregnancy body mass, gestational weight gain (GWG), and adiposity in the daughter. Design Retrospective cohort study among mother-nurse daughter dyads in the Nurses’ Health Study II and the Nurses’ Mothers’ Cohort. Mothers of participants completed questionnaires regarding their nurse-daughter in 2001. Participants 26,506 mother-nurse daughter dyads born between 1946 and 1964. Main outcome measures Body mass index of the nurse-daughter at age 18 and in 2001. Results At age 18, 561 (2.1%) daughters were obese (BMI greater than 30), and in 2001, 5,442 (22.0%) were obese. Adjusting for covariates, women whose mothers had a recalled pre-pregnancy BMI of 29 had a 6.1-fold increased risk of obesity at age 18 and a 3.4-fold risk of obesity in 2001, compared with women whose mothers had a pre-pregnancy BMI of 21. We found a U-shaped association between recalled GWG and offspring obesity. Compared with a maternal weight gain of 15–19 lb, GWG obesity risk at age 18 (odds ratio[OR] 1.54, 95% confidence interval[CI] 1.02–2.34) and in 2001 (OR 1.27, 95%CI 1.05–1.53). High weight gain (40+ lbs) was also associated with obesity risk at age 18 (OR 1.81, 95%CI 1.22–2.69) and in 2001 (OR 1.74, 95%CI 1.48–2.04). These associations were stronger among mothers who were overweight prior to pregnancy (p for interaction = 0.03), and they persisted with adjustment for birth weight. Conclusion A high recalled pre-pregnancy BMI and extremes of recalled GWG are associated with an increased risk of adolescent and adult obesity in offspring, particularly when the mother is overweight. Pre-pregnancy weight and GWG may be modifiable fetal origins of overweight and obesity in women. PMID:19528964

Assessing the quality of the ‘TurnStormer’ thinkLet as a collaboration engineering building block for the implementation of the promotion of Administrative Justice Act of South Africa

CSIR Research Space (South Africa)

Phahlamohlaka, J

2008-09-01

Full Text Available the simulation involves the awareness raising and training of participants in the use of Information and Communication Technology. The ideal progression of engagement to resolve an administrative action as required in PAJA is identical in all the research... training on the PAJA. The criteria of the analysis were also based on the notion of a thinkLet. The researchers were fortunate in that the independent researcher was one of the inventors of the thinkLet concept. Having succeeded in creating the Turn...

Radon and radon daughter measurements at and near the former Middlesex Sampling Plant, Middlesex, New Jersey

International Nuclear Information System (INIS)

Haywood, F.F.; Perdue, P.T.; Christian, D.J.; Leggett, R.W.; Dickson, H.W.; Myrick, T.E.

1980-03-01

The results of the radon and radon daughter measurements made to date (1978) at the Middlesex Sampling Plant in Middlesex, New Jersey, are presented in this report. These measurements were one portion of a more comprehensive radiological survey conducted at this site and the surrounding area from 1976 to 1978. The surveyed property served as a uranium ore sampling plant during the 1940's and early 1950's and as a result contains elevated levels of surface an subsurface contamination. On-site indoor radon daughter and radon concentrations exceeded both the US Surgeon General Guidelines and the Nuclear Regulatory Commission's maximum permissible concentration limits for radon (10 CFR Part 20) in all structures surveyed. Off-site structures showed concentrations of radon and radon daughters at or only slightly above background levels, except for one site where the radon levels were found to be above the 10 CFR Part 20 guidelines. Outdoor radon ad radon daughter concentrations, measured both on and off the site, were well below the guidelines, and the data give no indication of significant radon transport from the site

Laboratory measurements of the influence of air treatment devices on radon daughters

International Nuclear Information System (INIS)

Rajala, M.; Janka, K.; Graeffe, G.; Kulmala, V.; Lehtimaeki, M.

1984-01-01

This paper presents laboratory measurements in which the effect of air cleaners on radon decay products has been studied. Experiments show that both a high-efficiency particulate air filter and an electrostatic precipitator substantially decrease the total airborne radon daughter concentration leading to a situation where most of the decay products are unattached. However, in some situations the concentration of fine particles generated by the corona discharge in the electronic air cleaner becomes high enough to increase the total radon daughter concentration and decrease the free decay product concentration. Impurities in the air may have a notable role in the formation of these condensation nuclei. (Author)

An Exploration of Mothers' Attitudes towards Their Daughters' Menarche

Science.gov (United States)

Bennett, Clare; Harden, Jane

2014-01-01

Menarche is a significant milestone for young women, representing an important juncture between girlhood and maturation. The limited literature that exists suggests that a mother's reaction to her daughter's first periods can shape her experiences and perceptions of menstruation which, in turn, may impact on her self-image and, consequently,…

Occupational studies of radon daughters and lung cancer

International Nuclear Information System (INIS)

Hornung, R.W.; Ballew, M.A.

1988-01-01

The relationship between exposure to radon daughters and lung cancer mortality has been established. The purpose of this paper is to review some of the major studies of the health effects due to exposure to the decay products of radon gas and to discuss their potential implications with regard to risk associated with indoor radon. There has been much recent interest in the health hazards associated with radon largely motivated by the discovery of high levels of this radioactive gas in the Reading Prong (a geological area in Pennsylvania and New Jersey) and subsequently throughout the United States. Although at least three studies in the U.S. have been initiated to better estimate the lung cancer risks from low level indoor radon exposure, the results will not be known for several years. Consequently, present knowledge concerning such risks is almost entirely derived from studies of underground exposure to miners. Those studies effectively exclude women and children; therefore, assumptions must be made with regard to risk to a large segment of the population. Before discussing current health studies of radon daughter exposure, some background information is presented

Factors determinating the shape of survival curves of Escherichia coli cells irradiated by ionizing radiation with different LET. The dependence of the shape of survival curve on LET

International Nuclear Information System (INIS)

Kozubek, S.; Krasavin, E.A.; Fajsi, Ch.

1984-01-01

The dependence of the shape of bacterial sUrvival curve in the case of Escherichia coli Wild type, rec - and pol - mutants on linear energy transfer is considered. When increasing LET of the radiation the shouldered survival curves are transformed to exponential ones. In the case of sensitive mutants the transformation is observed for smaller values of LET. The dependence of cell sensitivity on LET calculated on the basis of Landau-Vavilov distribution is compared with earlier calculations. The comparison showed a good agreement between two methods of calculation for ions with 4 MeV per nucleon energy

Comparison of five-minute radon-daughter measurements with long-term radon and radon-daughter concentrations

International Nuclear Information System (INIS)

Young, J.A.; Jackson, P.O.; Thomas, V.W.

1983-01-01

Five-minute air filter radon daughter measurements were made in 84 buildings in Edgemont, South Dakota, in which annual average radon daughter concentrations have been determined from six 100-hour Radon Progeny Integrating Sampling Unit (RPISU) measurements. Averaging radon concentrations were also determined in 50 of these buildings using Terradex Track Etch detectors. The standard deviation of the difference between the (natural) logarithms of the RPISU annual averages and the logarithms of the air filter measurements (SD-ln) was found to be 0.52. This SD-ln is considerably smaller than the SD-ln of 0.71 between the RPISU annual averages and the air filter measurements reported by ALARA at Grand Junction, Colorado; presumably because a considerable number of air filter measurements in Edgemont were disregarded because of short turnover times or high wind speeds. Using the SD-ln of 0.52 it can be calculated that there would only be a 5% probability in Edgemont that the RPISU annual average would be greater than 0.015 WL if the five-minute measurement were equal to 0.010 WL. This indicates that the procedure used in Edgemont of clearing buildings from remedial action if the five-minute measurement were less than 0.010 WL was reasonable. There was about a 28% probability that the RPISU annual average would be less than 0.015 WL if the five-minute measurement were 0.033 WL, indicating that the procedure of performing an engineering assessment if the average of two five-minute measurements was greater than 0.033 WL was also reasonable. Comparison indicates that the average of two RPISU measurements taken six months apart would provide a dependable estimate of the annual average

Analytical solution and simplified analysis of coupled parent-daughter steady-state transport with multirate mass transfer

Science.gov (United States)

R. Haggerty

2013-01-01

In this technical note, a steady-state analytical solution of concentrations of a parent solute reacting to a daughter solute, both of which are undergoing transport and multirate mass transfer, is presented. Although the governing equations are complicated, the resulting solution can be expressed in simple terms. A function of the ratio of concentrations, In (daughter...

Parentification, substance use, and sex among adolescent daughters from ethnic minority families: the moderating role of monitoring.

Science.gov (United States)

Sang, Jina; Cederbaum, Julie A; Hurlburt, Michael S

2014-06-01

Guided by structural family systems theory, this study explored the relationship between parentification and adolescent daughters' sexual risk engagement and substance use. We also explored how adolescent reports of parental monitoring moderated the relationship between parentification and adolescent risk. Data were from a cross-sectional, cross-generational study of 176 mother-daughter dyads from low-income, inner-city, ethnic minority families. In this sample, which included a subset of mothers with HIV, parental physical symptoms were associated with slightly higher levels of parentification. Parentification was associated with adolescent daughters' intention to have sex (but not substance use) in a direction opposite to prediction. Higher parentification was associated with lower intention to have sex. Parental monitoring did not moderate relationships between parentification and adolescent risk. These findings highlight that despite the negative influence hypothesized in structural family systems theory, parentification was not associated with risk engagement of high-risk adolescent daughters in ethnic minority families with low income. © 2013 FPI, Inc.

[Acceptance of the vaccine against human papilloma virus from mothers to daughters aged 9 to 13 years old].

Science.gov (United States)

Godoy Verdugo, Melissa Karina; Zonana Nacach, Abraham; Anzaldo Campos, Maria Cecilia

2013-11-01

If you consider that at some point in life 50% of sexually active women have had an infection with the human papilloma virus is indisputable that any attempt to reduce the prevalence worth undertaking it. The vaccine to prevent HIV infection has not enjoyed the same degree of acceptance than others, hence the interest in knowing some of the reasons that has not achieved universal vaccination. To examine human papillomavirus (HPV) vaccine acceptability among mothers with adolescents girls between 9 and 13 years old. The mothers were interrogated about HVP vaccine acceptability, reasons provided for acceptance or non-acceptance and if mothers know that vaccine is offered free for public health institutions We interview a 250 mothers with 281 daughters, 38 daughters have already received the vaccine. Eighty nine percent of the mothers reacted positively to the possibility of vaccinating theirs daughters. The reasons of vaccine non-acceptance were because not knowing enough about infection, mother felt that their daughters were not at risk for acquiring HVP infection, the vaccine is new and mothers unknown side effects. Thirty nine percent of the mothers want to know more about the vaccine safety, 21% about length protection duration and 16% concerning about if the vaccine is effective. Fifty seven per cent of the mothers know that Health Secretary offers vaccine free. Mothers whom have been vaccinated their daughters, had daughters with lower age (9.8 +/- 0.9 vs 10.8 +/- 1.3 years, p = 0.0001), were more frequently married (79 vs 51%, p = 0.002) and more likely to report that they had heard about VPH vaccine from some source (100 vs 66%, p = 0.0001) that mothers have not yet vaccinated their daughters. The acceptability of VPH vaccine was 89%. Continued health education and propaganda is needed to promote a better knowledge of VPH vaccine.

Suicidal ideation among rural immigrant daughters-in-law with multi-roles as females, farmers and immigrants in China.

Science.gov (United States)

Qin, Qirong; Jin, Yu; Zhan, Shengwei; Yu, Xiaodong; Huang, Fen

2016-07-01

Suicide is a major public health issue in China, and suicidal ideation is an important step in the suicidal process. The purpose of this study was to understand the prevalence and correlates of suicidal ideation among rural immigrant daughters-in-law with multi-role of female, farmer and immigrant in China. A total of 939 participants including 474 local daughters-in-law and 465 immigrant daughters-in-law were surveyed using the self-rating questionnaire. Demographic characteristics, depression, anxiety, impulsivity and suicidal ideation were assessed. Results indicated that the lifetime prevalence of suicidal ideation among rural immigrant daughters-in-law was 9.68%. Physical disability, domestic violence and negative events demonstrated statistical significance by suicidal ideation (p suicidal ideation had higher scores of depression, anxiety and impulsiveness in the univariate analysis. Multivariate logistic regression showed that physical disability (OR = 7.43, 95%CI: 2.84-19.46), domestic violence (OR = 2.65, 95%CI: 1.02-6.88), depression (OR = 1.07, 95%CI: 1.01-1.12), impulsiveness (OR = 1.04, 95%CI: 1.01-1.08) and motor impulsiveness (OR = 1.07, 95%CI: 1.01-1.14) were significantly associated with suicidal ideation. Suicidal ideation is an issue that can't be ignored among rural immigrant daughters-in-law. And the findings should be considered for the intervention of the suicide among the rural immigrant daughters-in-law.

Radiosensitivity of yeast cells as a function of radiation LET

International Nuclear Information System (INIS)

Lobachevskij, P.N.; Krasavin, E.A.

1988-01-01

A model is proposed for interpreting the radiosensitivity of yeast cells as a function of linear energy transfer (LET) of ionizing radiation. The model takes into account the role of repair processes in sensitivity of yeast cells to ionizing radiation of different LET. Two types of repair are discussed: (1) a nonspecific repair (characteristic of both haploid and diploid cells), and (2) a diploid - soecific repair (characteristic of diploid cells only)

MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling.

Science.gov (United States)

Zhao, Chunnian; Sun, GuoQiang; Li, Shengxiu; Lang, Ming-Fei; Yang, Su; Li, Wendong; Shi, Yanhong

2010-02-02

Neural stem cell self-renewal and differentiation is orchestrated by precise control of gene expression involving nuclear receptor TLX. Let-7b, a member of the let-7 microRNA family, is expressed in mammalian brains and exhibits increased expression during neural differentiation. However, the role of let-7b in neural stem cell proliferation and differentiation remains unknown. Here we show that let-7b regulates neural stem cell proliferation and differentiation by targeting the stem cell regulator TLX and the cell cycle regulator cyclin D1. Overexpression of let-7b led to reduced neural stem cell proliferation and increased neural differentiation, whereas antisense knockdown of let-7b resulted in enhanced proliferation of neural stem cells. Moreover, in utero electroporation of let-7b to embryonic mouse brains led to reduced cell cycle progression in neural stem cells. Introducing an expression vector of Tlx or cyclin D1 that lacks the let-7b recognition site rescued let-7b-induced proliferation deficiency, suggesting that both TLX and cyclin D1 are important targets for let-7b-mediated regulation of neural stem cell proliferation. Let-7b, by targeting TLX and cyclin D1, establishes an efficient strategy to control neural stem cell proliferation and differentiation.

‘Unable to think in my mother’s tongue’: immigrant daughters in Alice Pung’s 'Unpolished Gem' and Hsu-Ming Teo’s 'Behind the Moon'

Directory of Open Access Journals (Sweden)

Alice Healy

2010-05-01

Full Text Available This paper explores ‘the immigrant’s story in translation’ through the various instances of language spoken between parents and children. It analyses the experience of immigrant daughters in two ‘Asian-Australian’ texts – Alice Pung’s recent memoir Unpolished Gem and Hsu-Ming Teo’s Behind the Moon. I position these texts in the context of the reception of literature labelled ‘Asian-Australian’ in the market, exploring Hsu-Ming Teo’s critique of such positioning. Centrally, the paper examines language in all the traditions and moral understandings that language applies, the transformative speech acts between parent and child, and the creative exploration of English as a spectre re-enforcing ‘white nationalism’.The experience of first generation Chinese Australians, in particular Chinese-Singaporeans, Chinese-Malaysians and Chinese-Cambodians, are explored in a reading of this novel and memoir. The point of connection between them is the very different languages between the generations, to the extent that the daughters think in different languages to their mothers, hence a shift in perceiving the world (and society around them.

A personal dosemeter of radon daughter products

International Nuclear Information System (INIS)

Burian, I.; Richter, M.; Ochec, J.; Dohnal, J.

1990-01-01

The OD 88 personal dosemeter for radon daughter products uses an alpha particle track detector and is of active type, with forced air aspiration through the detecting system. The pumping device consists of a miniature membrane pump and an electronic speed controller. The air flow rate is little affected by normal changes in supply voltage and/or pneumatic resistance of the pump circuit. The dosemeter is embedded in a miner's lamp and is fed from its accumulator battery. The pumping device is activated as the lamp is taken out of the charger and deactivated as it is slid into the charger again. The dosemeter head accommodates an AFPC filter on which the radon daughter products deposit. The energy of the alpha particles is reduced by an air layer and a Makrofol decelerating foil. The particles hitting the detector give rise to defects with an intensity proportional to the total linear stopping power at the moment of incidence; ideal tracks 10 μm in size require incident energy of 1.1 to 1.3 MeV. The detector is replaced in a month and worked up in an etching vessel, making use of the higher solubility of the detecting layer of the foil in NaOH at the spot of the alpha particle incidence. (P.A.). 4 figs., 17 refs

LET spectrometry with track etch detectors-Use in high-energy radiation fields

International Nuclear Information System (INIS)

Jadrnickova, I.; Spurny, F.

2008-01-01

For assessing the risk from ionizing radiation it is necessary to know not only the absorbed dose but also the quality of the radiation; radiation quality is connected with the physical quantity linear energy transfer (LET). One of the methods of determination of LET is based on chemically etched track detectors. This contribution concerns with a spectrometer of LET based on the track detectors and discusses some results obtained at: ·high-energy radiation reference field created at the SPS accelerator at CERN; and ·onboard of International Space Station where track-etch based LET spectrometer has been exposed 273 days during 'Matrjoshka - R' experiment. Results obtained are compared with the results of studies at some lower-energy neutron sources; some conclusions on the registrability of neutrons and the ability of this spectrometer to determine dose equivalent in high-energy radiation fields are formulated

An analytic solution to the time-dependent first-daughter fission-product plateout problem for multi-region isothermal slug flow

International Nuclear Information System (INIS)

Durkee, J.W. Jr.; Lee, C.E.

1985-01-01

The time-dependent, axisymmetric, isothermal slug flow convective-diffusion equation with radioactive decay is solved analytically to predict the behavior of a first-daughter fission-product undergoing gaseous transport through multiple materials in a cylindrical pipe. The integration coefficients are determined using the Davidon variable metric minimization method. The behavior of fission-product material deposited on the conduit wall is described by a standard mass-transfer model. The time-dependent plateout rate behavior, determined previously for parent fission-product deposition, is again evident for daughter product plateout. Dominance of the daughter plateout by parent deposition characteristics is apparent. The determination of the daughter wall mass-transfer and diffusion coefficient using a least-squares analysis of measured data depends upon a reasonably low ratio of parent/daughter half-lives. This is illustrated with 137 Cs/ 137 Ba(=2x10 5 ) and 140 Ba/ 140 La(=7.6), where for 137 Cs/ 137 Ba the solution sensitivity to the 137 Ba deposition parameters is small and for 140 Ba/ 140 La a reasonable solution is readily obtained. (author)

Mutational influences of low-dose and high let ionizing radiation in drosophila melanogaster

Science.gov (United States)

Lei, Huang; Fanjun, Kong; Sun, Yeqing

For cosmic environment consists of a varying kinds of radiation particles including high Z and energy ions which was charactered with low-dose and high RBE, it is important to determine the possible biofuctions of high LET radiation on human beings. To analyse the possible effectes of mutational influences of low-dose and high-LET ionizing radiation, wild fruit flies drosophila melanogaster were irradiated by 12C6+ ions in two LET levels (63.3 and 30 keV/µum) with different low doses from 2mGy to 2000mGy (2, 20, 200, 2000mGy) in HIRFL (Heavy ion radiation facility laboratory, lanzhou, China).In the same LET value group, the average polymorphic frequency was elevated along with adding doses of irradation, the frequency in 2000 mGy dose samples was significantly higher than other samples (p<0.01).These results suggest that genomic DNA sequence could be effected by low-dose and high-LET ionizing radiation, the irradiation dose is an important element in genomic mutation frequency origination.

mBAND analysis for high- and low-LET radiation-induced chromosome aberrations: A review

Energy Technology Data Exchange (ETDEWEB)

Hada, Megumi, E-mail: megumi.hada-1@nasa.gov [NASA Johnson Space Center, Houston, TX 77058 (United States); Universities Space Research Association, Houston, TX 77058 (United States); Wu Honglu; Cucinotta, Francis A. [NASA Johnson Space Center, Houston, TX 77058 (United States)

2011-06-03

During long-term space travel or cancer therapy, humans are exposed to high linear energy transfer (LET) energetic heavy ions. High-LET radiation is much more effective than low-LET radiation in causing various biological effects, including cell inactivation, genetic mutations, cataracts and cancer induction. Most of these biological endpoints are closely related to chromosomal damage, and cytogenetic damage can be utilized as a biomarker for radiation insults. Epidemiological data, mainly from survivors of the atomic bomb detonations in Japan, have enabled risk estimation from low-LET radiation exposures. The identification of a cytogenetic signature that distinguishes high- from low-LET exposure remains a long-term goal in radiobiology. Recently developed fluorescence in situ hybridization (FISH)-painting methodologies have revealed unique endpoints related to radiation quality. Heavy-ions induce a high fraction of complex-type exchanges, and possibly unique chromosome rearrangements. This review will concentrate on recent data obtained with multicolor banding in situ hybridization (mBAND) methods in mammalian cells exposed to low- and high-LET radiations. Chromosome analysis with mBAND technique allows detection of both inter- and intrachromosomal exchanges, and also distribution of the breakpoints of aberrations.

Comparison of a continuous working level monitor for radon daughters with conventional grab-sampling

International Nuclear Information System (INIS)

Bigu, J.; Grenier, M.

1982-08-01

An evaluation of a radon daughter monitor was carried out under laboratory controlled conditions. The monitor operates on continuous sampling and time integrating principles and was tested in conjunction with a newly designed, large radon/thoron room calibration facility. The monitor was tested under constant and rapidly fluctuating radiation conditions. Experimental data obtained with the monitor were compared with data obtained by conventional grab-sampling and with an automated radon daughter/thoron daughter 'grab-sampler'. The Working Level used in the tests ranged from less than 0.01 WL to approximately 10 WL. The measurements were carried out under low aerosol concentration (1 x 10 3 - 2 x 10 3 cm -3 , approximately) to study plate-out effects in the sampling head. Good agreement (within about 10 %) was found between the monitor, conventional grab-sampling and the automated grab-sampler. The monitor should prove quite flexible, useful and reliable for monitoring underground and surface environments in the uranium mining industry

An experimental chamber simulating the equilibrium between radon and its daughters in mine air

International Nuclear Information System (INIS)

Domanski, T.; Chruscielewski, W.; Orzechowski, W.

1981-01-01

An experimental chamber simulating the equilibrium between radon and its daughters in uranium mine air is described. The apparatus is useful for testing track detectors, air samplers, masks and filters and for determining occupational exposures. Increasing the humidity of the chamber air and increasing the amounts of aerosol injected both increase the values of the equilibrium factor, F. The equilibrium in the chamber air decreases after the aerosol injection but by using controlled pulse injections it was shown that the stability of F could be maintained inside the chamber for 4 hours. Results are also given for the structure of the equilibrium between radon and its daughters Qsub(i)/Q 0 in the chamber air as a function of the chamber air factor F and also for the potential α-energy of unattached products in relation to the total α-potential energy of radon daughter products in the chamber air as a function of factor F. (U.K.)

Prophage λ induction by ionizing radiation of different LETs

International Nuclear Information System (INIS)

Bonev, M.N.; Kozubek, S.; Krasavin, E.A.; Amirtaev, K.G.

1988-01-01

The λ prophage induction caused by γ-irradiation and accelerated heavy ions with different LET was studied in variety Escherichia coli strains. The induction frequency on the dose I(D) shaped a curve with a maximum in the strains which possess recA + /lexA + genotype. The inductivity of these strains increases as well as LET and an alteration poor → rich media does it. Unlike I(D) for recA + /lexA + , the dependence I(D) for recA, lexA and recBC strains was a constant. 15 refs.; 6 figs.; 3 tabs

Quantification of the lung cancer risk from radon daughter exposure in dwellings - an epidemiological approach

International Nuclear Information System (INIS)

Edling, C.; Wingren, G.; Axelson, O.

1986-01-01

Some epidemiological studies have suggested a relationship between the concentration of decay products from radon, i.e., radon daughter exposure, in dwellings and lung cancer. Further experiences made from radon measurements have indicated that both building material and particularly the radioactivity in the ground is of importance for the leakage of radon into the houses. In Sweden, a survey is now ongoing in 15 municipalities with alum shale deposits, and in one area a case-referent evaluation has been made, considering building materials, ground conditions and smoking habits. The size of the study is small, but the results suggest that a risk is at hand and that there is a multiplicative effect from smoking and radon daughter exposure. About 30% of the lung cancers in the studied population might be attributable to elevated and potentially avoidable exposure to radon and radon daughters. (author)

From mothers to daughters: transgenerational food and diet communication in an underserved group.

Science.gov (United States)

Wilson, Diane Baer; Musham, Catherine; McLellan, Mary S

2004-01-01

Studies show that young girls are highly influenced by their mothers' attitudes toward food and body image. To investigate the nature of the information about food that mothers transfer to their daughters, the researchers used focus groups comprising African American women. Results suggest that when educators work with low-income African American women, they should be cognizant of overeating from the perspectives of early food scarcity, reverence for the mother's authoritative role in the family and respect for cultural differences in body size norms. In addition, nutrition educators should counsel young mothers to understand the impact of their eating habits on their daughters.

Some aspects of radon and its daughter-products in man and his environment

International Nuclear Information System (INIS)

Rundo, J.; Markun, F.; Plondke, N.J.; Sha, J.Y.

1981-01-01

A major but short-lived postprandial increase in the exhalation rate of radon by persons containing no radium was observed. The concentrations of radon and its short-lived daughter-products in houses was unusually high (> 5 to 10 pCi l - 1 , > 185 to 370 Bq m - 3 ) in some houses with unpaved crawl spaces, and with concrete basements. External counting of radon daughter-products in the residents of one of the radon-contaminated houses indicated that there may be interference with the assay of plutonium in the lungs of persons who live in those houses

Comparative toxicity in rats vs hamsters of inhaled radon daughters with and without uranium ore dust

International Nuclear Information System (INIS)

Gaven, J.C.; Palmer, R.F.; McDonald, K.E.; Lund, J.E.; Stuart, B.O.

1977-01-01

Simultaneous exposures of rats and hamsters to inhaled radon daughters, with and without uranium ore dust, were performed daily for five months. Pulmonary pathology developing in 6 to 13 mo after cessation of daily exposures included interstitial fibrosis, emphysema, epithelial hyperplasia, squamous metaplasia, and malignant neoplasia. Rats showed a greater variety and more severe response to these uranium mine inhalation exposures than did hamsters. Inhalation of radon daughters with uranium ore dust displayed the site of greatest damage, including squamous carcinoma, from the nasopharynx to the lungs. Sixty percent of the rats exposed to radon daughters with ore dust developed primary pulmonary carcinomas, providing an appropriate short-term experimental animal model for investigation of respiratory tract carcinogenesis in uranium miners

TH-CD-209-06: LET-Based Adjustment of IMPT Plans Using Prioritized Optimization

Energy Technology Data Exchange (ETDEWEB)

Unkelbach, J; Giantsoudi, D; Paganetti, H [Massachusetts General Hospital, Boston, MA (United States); Botas, P [Massachusetts General Hospital, Boston, MA (United States); Heidelberg University, Heidelberg, DE (Germany); Qin, N; Jia, X [The University of Texas Southwestern Medical Ctr, Dallas, TX (United States)

2016-06-15

Purpose: In-vitro experiments suggest an increase in proton relative biological effectiveness (RBE) towards the end of range. However, proton treatment planning and dose reporting for clinical outcome assessment has been based on physical dose and constant RBE. Therefore, treatment planning for intensity-modulated proton therapy (IMPT) is unlikely to transition radically to pure RBE-based planning. We suggest a hybrid approach where treatment plans are initially created based on physical dose constraints and prescriptions, and are subsequently altered to avoid high linear energy transfer (LET) in critical structures while limiting the degradation of the physical dose distribution. Methods: To allow fast optimization based on dose and LET we extended a GPU-based Monte-Carlo code towards providing dose-averaged LET in addition to dose for all pencil beams. After optimizing an initial IMPT plan based on physical dose, a prioritized optimization scheme is used to modify the LET distribution while constraining the physical dose objectives to values close to the initial plan. The LET optimization step is performed based on objective functions evaluated for the product of physical dose and LET (LETxD). To first approximation, LETxD represents a measure of the additional biological dose that is caused by high LET. Regarding optimization techniques, LETxD has the advantage of being a linear function of the pencil beam intensities. Results: The method is applicable to treatments where serial critical structures with maximum dose constraint are located in or near the target. We studied intra-cranial tumors (high-grade meningiomas, base-of-skull chordomas) where the target (CTV) overlaps with the brainstem and optic structures. Often, high LETxD in critical structures can be avoided while minimally compromising physical dose planning objectives. Conclusion: LET-based re-optimization of IMPT plans represents a pragmatic approach to bridge the gap between purely physical dose

The mother-daughter guilt dynamic: effects of type 1 diabetes during life transitions.

Science.gov (United States)

Rasmussen, Bodil; Dunning, Trisha; Cox, Helen; O'Connell, Beverly

2008-11-01

The aim of the study was to explore and describe the strategies young women with type 1 diabetes used to manage life transitions. The paper describes one aspect of how guilt dynamic often operates between mothers and daughters and how the women managed the guilt dynamic to create stability in their lives. When a child is diagnosed with diabetes, major transitional changes occur in the relationships between the mother and her child. The changes affect the psychological and social aspects of their lives and have a major impact on how young women manage their diabetes. A guilt dynamic between mothers and young women with diabetes emerged as a major theme in a larger study that investigated how young women with diabetes managed life transitions. Although the literature indicates that mothers of chronically ill children experience guilt feelings towards their children, little research was identified that addressed the emotional dynamics between mothers and daughters with diabetes. Using grounded theory method, interviews were conducted with 20 women with type 1 diabetes and five mothers during 2002 and 2003. Constant comparative analysis was used to analyse the data and develop an in-depth understanding of the experience of living with diabetes during life transitions. The findings revealed that guilt feelings created a two-way dependency between mothers and their daughters with diabetes. The two-way dependency involved feelings of being a burden to each other, difficulty balancing responsibilities for diabetes management, difficulty relinquishing emotional and social dependency especially during life transitions. In addition, these issues were rarely discussed openly with each other or with health professionals. The findings provide additional information about the human experience of the mother-daughter relationship and the effect on coping with diabetes in the context of life transitions. Understanding the impact diabetes has on the emotional and social well being of

Late Maternal Folate Supplementation Rescues from Methyl Donor Deficiency-Associated Brain Defects by Restoring Let-7 and miR-34 Pathways.

Science.gov (United States)

Geoffroy, Andréa; Kerek, Racha; Pourié, Grégory; Helle, Déborah; Guéant, Jean-Louis; Daval, Jean-Luc; Bossenmeyer-Pourié, Carine

2017-09-01

The micronutrients folate and vitamin B12 are essential for the proper development of the central nervous system, and their deficiency during pregnancy has been associated with a wide range of disorders. They act as methyl donors in the one-carbon metabolism which critically influences epigenetic mechanisms. In order to depict further underlying mechanisms, we investigated the role of let-7 and miR-34, two microRNAs regulated by methylation, on a rat model of maternal deficiency. In several countries, public health policies recommend periconceptional supplementation with folic acid. However, the question about the duration and periodicity of supplementation remains. We therefore tested maternal supply (3 mg/kg/day) during the last third of gestation from embryonic days (E) 13 to 20. Methyl donor deficiency-related developmental disorders at E20, including cerebellar and interhemispheric suture defects and atrophy of selective cerebral layers, were associated with increased brain expression (by 2.5-fold) of let-7a and miR-34a, with subsequent downregulation of their regulatory targets such as Trim71 and Notch signaling partners, respectively. These processes could be reversed by siRNA strategy in differentiating neuroprogenitors lacking folate, with improvement of their morphological characteristics. While folic acid supplementation helped restoring the levels of let-7a and miR-34a and their downstream targets, it led to a reduction of structural and functional defects taking place during the perinatal period. Our data outline the potential role of let-7 and miR-34 and their related signaling pathways in the developmental defects following gestational methyl donor deficiency and support the likely usefulness of late folate supplementation in at risk women.

Organizational changes of the daughter basal complex during the parasite replication of Toxoplasma gondii.

Directory of Open Access Journals (Sweden)

Ke Hu

2008-01-01

Full Text Available The apicomplexans are a large group of parasitic protozoa, many of which are important human and animal pathogens, including Plasmodium falciparum and Toxoplasma gondii. These parasites cause disease only when they replicate, and their replication is critically dependent on the proper assembly of the parasite cytoskeletons during cell division. In addition to their importance in pathogenesis, the apicomplexan parasite cytoskeletons are spectacular structures. Therefore, understanding the cytoskeletal biogenesis of these parasites is important not only for parasitology but also of general interest to broader cell biology. Previously, we found that the basal end of T. gondii contains a novel cytoskeletal assembly, the basal complex, a cytoskeletal compartment constructed in concert with the daughter cortical cytoskeleton during cell division. This study focuses on key events during the biogenesis of the basal complex using high resolution light microscopy, and reveals that daughter basal complexes are established around the duplicated centrioles independently of the structural integrity of the daughter cortical cytoskeleton, and that they are dynamic "caps" at the growing ends of the daughters. Compartmentation and polarization of the basal complex is first revealed at a late stage of cell division upon the recruitment of an EF-hand containing calcium binding protein, TgCentrin2. This correlates with the constriction of the basal complex, a process that can be artificially induced by increasing cellular calcium concentration. The basal complex is therefore likely to be a new kind of centrin-based contractile apparatus.

Second workshop on radon and radon daughters in urban communities associated with uranium mining and processing

International Nuclear Information System (INIS)

1979-01-01

A second meeting of Atomic Energy Control Board staff, federal and provincial government representatives, and consultants was held to discuss progress in reducing the concentrations of radon and its daughter products in houses in communities like Bancroft, Elliot Lake, Port Hope, and Uranium City. Participants discussed successful and unsuccessful remedial techniques, possible sources of radon, and methods of measuring radon and radon daughters in buildings

Limitation schemes to decrease the radon daughters in indoor air

International Nuclear Information System (INIS)

Swedjemark, G.A.

1986-01-01

The limitation schemes to decrease the radon daughter concentrations in Swedish homes are described. The application of the Swedish provisional limitation system in use since 1980 is also reported. As a background the radon source and the international and national recommedations in other countries are reviewed. (author)

The Othering in Kazuo Ishiguro’s Never Let Me Go

Directory of Open Access Journals (Sweden)

Matava Vichiensing

2017-08-01

Full Text Available In this article, I will investigate the concept of ‘othering’ originally as part of a post-colonial theory. This concept is interested in many academic areas, including a literary study. In Kazuo Ishiguro’s novel Never Let Me Go is about human clones raised for organs. The clones are excluded and discriminated to be ‘the other’ from the normal people. The manifestations of othering in Never Let Me Go can be presented in the forms of linguistic features, indoctrination, objectification, and assimilation. Although the othering phenomenon can be found in the reality, it can be appeared in literary texts as well. The findings show that the study of Kazuo Ishiguro’s Never Let Me Go helps us to understand and aware of how the negative consequences of the othering process affect undesirable treatments in the society as a whole.

Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes.

Science.gov (United States)

Novak, Zsofia A; Wainman, Alan; Gartenmann, Lisa; Raff, Jordan W

2016-06-20

Centrosomes and cilia are organized by a centriole pair comprising an older mother and a younger daughter. Centriole numbers are tightly regulated, and daughter centrioles (which assemble in S phase) cannot themselves duplicate or organize centrosomes until they have passed through mitosis. It is unclear how this mitotic "centriole conversion" is regulated, but it requires Plk1/Polo kinase. Here we show that in flies, Cdk1 phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles and is required for the subsequent recruitment of Asterless (Asl), a protein essential for centriole duplication and mitotic centrosome assembly. Point mutations in Sas-4 that prevent Cdk1 phosphorylation or Polo docking do not block centriole disengagement during mitosis, but block efficient centriole conversion and lead to embryonic lethality. These observations can explain why daughter centrioles have to pass through mitosis before they can duplicate and organize a centrosome. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

Let-7b Regulates Myoblast Proliferation by Inhibiting IGF2BP3 Expression in Dwarf and Normal Chicken

Science.gov (United States)

Lin, Shumao; Luo, Wen; Ye, Yaqiong; Bekele, Endashaw J.; Nie, Qinghua; Li, Yugu; Zhang, Xiquan

2017-01-01

The sex-linked dwarf chicken is caused by the mutation of growth hormone receptor (GHR) gene and characterized by shorter shanks, lower body weight, smaller muscle fiber diameter and fewer muscle fiber number. However, the precise regulatory pathways that lead to the inhibition of skeletal muscle growth in dwarf chickens still remain unclear. Here we found a let-7b mediated pathway might play important role in the regulation of dwarf chicken skeletal muscle growth. Let-7b has higher expression in the skeletal muscle of dwarf chicken than in normal chicken, and the expression of insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), which is a translational activator of IGF2, showed opposite expression trend to let-7b. In vitro cellular assays validated that let-7b directly inhibits IGF2BP3 expression through binding to its 3′UTR region, and the protein level but not mRNA level of IGF2 would be reduced in let-7b overexpressed chicken myoblast. Let-7b can inhibit cell proliferation and induce cell cycle arrest in chicken myoblast through let-7b-IGF2BP3-IGF2 signaling pathway. Additionally, let-7b can also regulate skeletal muscle growth through let-7b-GHR-GHR downstream genes pathway, but this pathway is non-existent in dwarf chicken because of the deletion mutation of GHR 3′UTR. Notably, as the loss binding site of GHR for let-7b, let-7b has enhanced its binding and inhibition on IGF2BP3 in dwarf myoblast, suggesting that the miRNA can balance its inhibiting effect through dynamic regulate its binding to target genes. Collectively, these results not only indicate that let-7b can inhibit skeletal muscle growth through let-7b-IGF2BP3-IGF2 signaling pathway, but also show that let-7b regulates myoblast proliferation by inhibiting IGF2BP3 expression in dwarf and normal chickens. PMID:28736533

Metrology and monitoring of radon, thoron and their daughter products

International Nuclear Information System (INIS)

1985-01-01

The principles of measurement and monitoring are described as applied to radon- and thoron gases and their daughter products in occupational and non-occupational environments. Various methods of measurement, such as grab-sampling, continuous monitoring, integrated measurements and personal dosimetry are discussed. Uncertainties in different measurement methods are compared. An account of unattached fraction and plateout of radon daughters is included. General principles and guidelines for monitoring are presented for the purposes of practical radiation protection as well as research applications. Calibration aspects of measurement instruments are described and procedures for interlaboratory calibration are suggested. Sampling strategies for occupational and non-occupational environments are discussed and radiation protection training requirements are identified. Where sufficient information and consensus exist, guidelines on apparatus, methods and procedures for monitoring are provided. A summary of regulations in force or being developed and recommendations for monitoring radiation exposure to radon and its decay products in countries of the OECD is provided, together with cost estimates for national indoor radon surveys

let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex

Directory of Open Access Journals (Sweden)

Tsai-Tsen Liao

2016-01-01

Full Text Available Let-7 is crucial for both stem cell differentiation and tumor suppression. Here, we demonstrate a chromatin-dependent mechanism of let-7 in regulating target gene expression in cancer cells. Let-7 directly represses the expression of AT-rich interacting domain 3B (ARID3B, ARID3A, and importin-9. In the absence of let-7, importin-9 facilitates the nuclear import of ARID3A, which then forms a complex with ARID3B. The nuclear ARID3B complex recruits histone demethylase 4C to reduce histone 3 lysine 9 trimethylation and promotes the transcription of stemness factors. Functionally, expression of ARID3B is critical for the tumor initiation in let-7-depleted cancer cells. An inverse association between let-7 and ARID3A/ARID3B and prognostic significance is demonstrated in head and neck cancer patients. These results highlight a chromatin-dependent mechanism where let-7 regulates cancer stemness through ARID3B.

Cytotoxic and mutagenic effects of high let charged particles on human skin fibroblasts

International Nuclear Information System (INIS)

Tsuboi, Koji.; Park, M.S.; Chen, D.J.; Yang, T.C.

1992-01-01

Cytotoxic and mutagenic effects of high LET charged particles were quantitatively measured using primary cultures of human skin fibroblasts. The span of LETs selected were from 25 keV/μm(330 MeV/u) to 920 keV/μm (600 MeV/u). Mutations were scored at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus using 6-thioguanine (6-TG) for selection. Exposure to these high LET charged particles resulted in exponential survival curves whereas mutant induction was fitted by a linear model. The Relative Biological Effect (RBE) for cell-killing ranged from 3.73 to 1.25, while that for mutant induction ranged from 5.74 to 0.48. Maximum RBE values were obtained at the LET of 150 keV/μm. The inactivation cross-section (σ i ) and the action cross-section for mutant induction (σ m ) ranged from 2.2 to 92.0 μm 2 and 0.09 to 5.56 x 10 -3 μm 2 respectively, the maximum values were obtained by 56 Fe with an LET of 200 keV/μm. The mutagenicity (σ m /σ i ) ranged from 2.05 to 7.99 x 10 -5 with the maximum value at 150 keV/μm. Furthermore, the results of multiplex polymerase chain reaction (PCR) of some of the mutants induced by charged particles indicate that higher LET beams are more likely to cause larger deletions in the hprt locus. (author)

Let7a involves in neural stem cell differentiation relating with TLX level.

Science.gov (United States)

Song, Juhyun; Cho, Kyoung Joo; Oh, Yumi; Lee, Jong Eun

2015-07-10

Neural stem cells (NSCs) have the potential for differentiation into neurons known as a groundbreaking therapeutic solution for central nervous system (CNS) diseases. To resolve the therapeutic efficiency of NSCs, recent researchers have focused on the study on microRNA's role in CNS. Some micro RNAs have been reported significant functions in NSC self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. MicroRNA-Let7a (Let7a) has known as the regulator of diverse cellular mechanisms including cell differentiation and proliferation. In present study, we investigated whether Let7a regulates NSC differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal, proliferation and differentiation. We performed the following experiments: western blot analysis, TaqMan assay, RT-PCR, and immunocytochemistry to confirm the alteration of NSCs. Our data showed that let7a play important roles in controlling NSC fate determination. Thus, manipulating Let-7A and TLX could be a novel strategy to enhance the efficiency of NSC's neuronal differentiation for CNS disorders. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

[Response of HeLa cells to mitomycine C. III. The analysis of nucleoli of mother and daughter cells].

Science.gov (United States)

Petrov, Iu P; Neguliaev, Iu A; Tsupkina, N V

2014-01-01

The comparative analysis of the number of nucleoli in cells of the established HeLa-M line was carried out before and after exposure to mitomycin C in a concentration of 10 μg/ml for 2 h. Using time-lapse microscopy, nucleoli in mother and their respective daughter cells were computed. It has been shown that the average number of nucleoli per cell is generally higher in daughter cells than in mother cells, and a standard deviation, on the contrary, decreases. An average number of nucleoli in daughter cells, whose mother cells had been treated with mitomycin C, was higher than in corresponding cells of control group. The separate analysis has been performed for the cells having from 1 to 4 nucleoli. Nonrandom complete coincidence of the number of nucleoli in mather and daughter cells has been typicaly shown for about 1/7 of the total cell population. Mitomycin C reduces this value of about 1.5 times.

HPV vaccine acceptance among African-American mothers and their daughters: an inquiry grounded in culture.

Science.gov (United States)

Galbraith-Gyan, Kayoll V; Lechuga, Julia; Jenerette, Coretta M; Palmer, Mary H; Moore, Angelo D; Hamilton, Jill B

2017-05-29

Much of the research on African-Americans' HPV vaccine acceptance has largely focused on racial/ethnic differences related to cognitive, socio-economical, and structural factors that contribute to differences in HPV vaccine acceptance and completion. A growing body of literature suggest that cultural factors, such as mistrust of healthcare providers (HCPs) and the healthcare system, religion, and social norms related to appropriate sexual behaviors, also plays a prominent role in their HPV vaccine acceptance. However, these studies were limited in their use of theoretical approaches necessary to conceptualize and operationalize culture. To explore the influence of culture on African-American mothers' and daughters' HPV vaccine acceptance using the PEN-3, a culturally-centered conceptual framework. Grounded theory techniques were used to explore cultural factors that influenced the acceptance of the HPV vaccine among African-American mothers (n = 28) and their daughters (n = 34). Positive attitudes towards vaccination stemmed from beliefs that the HPV vaccine has cancer prevention benefits and that vaccinations in general protected against infectious diseases. Negative attitudes stemmed from beliefs that the HPV vaccine was too new, not effective, daughters were too young, and that vaccines were not a one-size-fits-all intervention. Majority of mothers and daughters indicated that their religious doctrine did not impede their HPV vaccination decisions. For a few mothers, religious beliefs could not be separated from their HPV vaccination decisions and ultimately deterred HPV vaccine acceptance. HCP recommendations were valued however mothers were often dissatisfied with the detail of information communicated. Support networks provided both positive and negative types of social support to mothers and daughters. The media highlighted the cancer prevention benefits of the HPV vaccine and unintentionally communicated negative information of the HPV vaccine

High energy ion irradiation effects on polymer materials. LET dependence of G value of scission of polymethylmethacrylate (PMMA)

Energy Technology Data Exchange (ETDEWEB)

Kudoh, H; Sasuga, T; Seguchi, T [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

1997-03-01

Linear energy transfer (LET) dependence on the probability of main chain scission of polymethylmethacrylate (PMMA) was investigated. The probability was obtained from decreases in molecular weight measured by the gel permeation chromatography (GPC), and LET was evaluated by TRIM code. The scission probability as a function of LET was almost constant in the low LET, and decreased in the high LET ion irradiation. The mechanism was interpreted from the model of spur-overlapping along an ion`s path. (author)

Let-7b-mediated suppression of basigin expression and metastasis in mouse melanoma cells

International Nuclear Information System (INIS)

Fu, Tzu-Yen; Chang, Chia-Che; Lin, Chun-Ting; Lai, Cong-Hao; Peng, Shao-Yu; Ko, Yi-Ju; Tang, Pin-Chi

2011-01-01

Basigin (Bsg), also called extracellular matrix metalloproteinase inducer (EMMPRIN), is highly expressed on the surface of tumor cells and stimulates adjacent fibroblasts or tumor cells to produce matrix metalloproteinases (mmps). It has been shown that Bsg plays an important role in growth, development, cell differentiation, and tumor progression. MicroRNAs (miRNAs) are a class of short endogenous non-protein coding RNAs of 20-25 nucleotides (nt) that function as post-transcriptional regulators of gene expression by base-pairing to their target mRNAs and thereby mediate cleavage of target mRNAs or translational repression. In this study, let-7b, one of the let-7 family members, was investigated for its effect on the growth and invasiveness of the mouse melanoma cell line B16-F10. We have shown that let-7b can suppress the expression of Bsg in B16-F10 cells and also provided evidence that this suppression could result in the indirect suppression of mmp-9. The ability of B16-F10 cells transfected with let-7b to invade or migrate was significantly reduced. In addition, let-7b transfected B16-F10 cells displayed an inhibition of both cellular proliferation and colony formation. Furthermore, it was shown that the overexpression of let-7b in B16-F10 cells could reduce lung metastasis. Taken together, the present study identifies let-7b as a tumor suppressor that represses cancer cell proliferation and migration as well as tumor metastasis in mouse melanoma cells.

Let-7b-mediated suppression of basigin expression and metastasis in mouse melanoma cells

Energy Technology Data Exchange (ETDEWEB)

Fu, Tzu-Yen [Department of Animal Science, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Chang, Chia-Che [Institute of Biomedical Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Graduate Institute of Basic Medical Science, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan (China); Lin, Chun-Ting [Department of Animal Science, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Lai, Cong-Hao [Institute of Biomedical Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Department of Life Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Peng, Shao-Yu; Ko, Yi-Ju [Department of Animal Science, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China); Tang, Pin-Chi, E-mail: pctang@dragon.nchu.edu.tw [Department of Animal Science, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan (China)

2011-02-15

Basigin (Bsg), also called extracellular matrix metalloproteinase inducer (EMMPRIN), is highly expressed on the surface of tumor cells and stimulates adjacent fibroblasts or tumor cells to produce matrix metalloproteinases (mmps). It has been shown that Bsg plays an important role in growth, development, cell differentiation, and tumor progression. MicroRNAs (miRNAs) are a class of short endogenous non-protein coding RNAs of 20-25 nucleotides (nt) that function as post-transcriptional regulators of gene expression by base-pairing to their target mRNAs and thereby mediate cleavage of target mRNAs or translational repression. In this study, let-7b, one of the let-7 family members, was investigated for its effect on the growth and invasiveness of the mouse melanoma cell line B16-F10. We have shown that let-7b can suppress the expression of Bsg in B16-F10 cells and also provided evidence that this suppression could result in the indirect suppression of mmp-9. The ability of B16-F10 cells transfected with let-7b to invade or migrate was significantly reduced. In addition, let-7b transfected B16-F10 cells displayed an inhibition of both cellular proliferation and colony formation. Furthermore, it was shown that the overexpression of let-7b in B16-F10 cells could reduce lung metastasis. Taken together, the present study identifies let-7b as a tumor suppressor that represses cancer cell proliferation and migration as well as tumor metastasis in mouse melanoma cells.

Harderian Gland Tumorigenesis: Low-Dose and LET Response

Energy Technology Data Exchange (ETDEWEB)

Chang, Polly Y. [SRI International, Menlo Park, CA (United States). Biosciences Div.; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Cucinotta, Francis A. [Univ. of Nevada, Las Vegas, NV (United States). Dept. of Health Physics and Diagnostic Sciences; Bjornstad, Kathleen A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Bakke, James [SRI International, Menlo Park, CA (United States). Biosciences Div.; Rosen, Chris J. [SRI International, Menlo Park, CA (United States). Biosciences Div.; Du, Nicholas [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Fairchild, David G. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Cacao, Eliedonna [Univ. of Nevada, Las Vegas, NV (United States). Dept. of Health Physics and Diagnostic Sciences; Blakely, Eleanor A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.

2016-04-19

Increased cancer risk remains a primary concern for travel into deep space and may preclude manned missions to Mars due to large uncertainties that currently exist in estimating cancer risk from the spectrum of radiations found in space with the very limited available human epidemiological radiation-induced cancer data. Existing data on human risk of cancer from X-ray and gamma-ray exposure must be scaled to the many types and fluences of radiations found in space using radiation quality factors and dose-rate modification factors, and assuming linearity of response since the shapes of the dose responses at low doses below 100 mSv are unknown. The goal of this work was to reduce uncertainties in the relative biological effect (RBE) and linear energy transfer (LET) relationship for space-relevant doses of charged-particle radiation-induced carcinogenesis. The historical data from the studies of Fry et al. and Alpen et al. for Harderian gland (HG) tumors in the female CB6F1 strain of mouse represent the most complete set of experimental observations, including dose dependence, available on a specific radiation-induced tumor in an experimental animal using heavy ion beams that are found in the cosmic radiation spectrum. However, these data lack complete information on low-dose responses below 0.1 Gy, and for chronic low-dose-rate exposures, and there are gaps in the LET region between 25 and 190 keV/μm. In this study, we used the historical HG tumorigenesis data as reference, and obtained HG tumor data for 260 MeV/u silicon (LET ~70 keV/μm) and 1,000 MeV/u titanium (LET ~100 keV/μm) to fill existing gaps of data in this LET range to improve our understanding of the dose-response curve at low doses, to test for deviations from linearity and to provide RBE estimates. Animals were also exposed to five daily fractions of 0.026 or 0.052 Gy of 1,000 MeV/u titanium ions to simulate chronic exposure, and HG tumorigenesis from this fractionated study were compared to the

Experiences of parents whose sons or daughters have (had) attempted suicide

DEFF Research Database (Denmark)

Buus, Niels; Caspersen, Jimmy; Hansen, Rasmus

2014-01-01

problem and relatives are understood as playing an important role in suicide prevention; however, suicide and suicidal behaviour affect the relatives' lives profoundly, both emotionally and socially, and the psychosocial impact on families is underresearched. DESIGN: Focus groups with parents of sons......AIM: The aim of this exploratory study was to gain further insights into the experiences of parents of sons or daughters who have attempted suicide and how these parents respond to the increased psychosocial burden following the suicide attempt(s). BACKGROUND: Suicide is a major public health...... or daughters who have attempted suicide. METHODS: In January and February 2012, we interviewed two groups of parents recruited at a counselling programme for relatives of persons who have attempted suicide. The analysis combined a thematic analysis with a subsequent analysis of how the themes were negotiated...

Protecting our Khmer daughters: ghosts of the past, uncertain futures, and the human papillomavirus vaccine.

Science.gov (United States)

Burke, Nancy J; Do, Huyen H; Talbot, Jocelyn; Sos, Channdara; Ros, Srey; Taylor, Victoria M

2015-01-01

The FDA approved the first human papillomavirus (HPV) vaccine in 2006. Research into parental decision-making and concerns about HPV vaccination highlights questions about parenting and parents' role in the crafting of their daughters' future sexuality. In contrast to much of this literature, we explore narratives from interviews with Cambodian mothers of HPV vaccine-age eligible daughters who experienced genocide and came to the USA as refugees. We conducted in-depth, in-person interviews with 25 Cambodian mothers of HPV vaccine-age eligible daughters. Interviews were conducted in Khmer and translated into English for analysis. We followed standard qualitative analysis techniques including iterative data review, multiple coders, and 'member checking.' Five members of the research team reviewed all transcripts and two members independently coded each transcript for concepts and themes. Interview narratives highlight the presence of the past alongside desires for protection from uncertain futures. We turn to Quesada and colleagues' concept structural vulnerability to outline the constraints posed by these women's positionalities as genocide survivors when faced with making decisions in an area with which they have little direct knowledge or background: cervical cancer prevention. Our study sheds light on the prioritization of various protective health practices, including but not exclusive to HPV vaccination, for Khmer mothers, as well as the rationalities informing decision-making regarding their daughters' health.

Barber-Say syndrome in a father and daughter.

Science.gov (United States)

Roche, Nathalie; Houtmeyers, Philippe; Janssens, Sandra; Blondeel, Philllip

2010-10-01

We report on a father to daughter transmission of Barber-Say syndrome (BSS), a rare, congenital disorder characterized by severe generalized hypertrichosis, macrostomia, ocular telecanthus, bulbous nose and atrophic skin. These two cases further support the autosomal dominant inheritance. Both presented with the typical BSS symptoms but the phenotypic expression in the father was milder. Treatment is challenging for both patients and doctors, requiring a multidisciplinary approach. Copyright © 2010 Wiley-Liss, Inc.

Combined chemo/radiotherapy of cancer: present state and prospects for use with high-LET radiotherapy

International Nuclear Information System (INIS)

Phillips, T.L.

1979-01-01

Cytotoxic chemotherapy added to low-LET radiotherapy has improved survival and in some cases local control. In some instances the combination has yielded increased normal tissue damage. Similar results can be expected, as confirmed by intestinal crypt cell experiments, with high-LET. Less interaction than with low-LET appears to occur with agents blocking sublethal damage repair or causing synchronization. (author)

Characterization and expression patterns of let-7 microRNA in the silkworm (Bombyx mori

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Hong Kaili

2007-07-01

Full Text Available Abstract Background lin-4 and let-7, the two founding members of heterochronic microRNA genes, are firstly confirmed in Caenorhabditis elegans to control the proper timing of developmental programs in a heterochronic pathway. let-7 has been thought to trigger the onset of adulthood across animal phyla. Ecdysone and Broad-Complex are required for the temporal expression of let-7 in Drosophila melanogaster. For a better understanding of the conservation and functions of let-7, we seek to explore how it is expressed in the silkworm (Bombyx mori. Results One member of let-7 family has been identified in silkworm computationally and experimentally. All known members of this family share the same nucleotides at ten positions within the mature sequences. Sequence logo and phylogenetic tree show that they are not only conserved but diversify to some extent among some species. The bmo-let-7 was very lowly expressed in ova harvested from newborn unmated female adult and in individuals from the first molt to the early third instar, highly expressed after the third molt, and the most abundant expression was observed after mounting, particularly after pupation. The expression levels were higher at the end of each instar and at the beginning of each molt than at other periods, coinciding with the pulse of ecdysone and BR-C as a whole. Using cultured ovary cell line, BmN-SWU1, we examined the effect of altered ecdysone levels on bmo-let-7 expression. The expression was also detected in various tissues of day 3 of the fifth instar and of from day 7 of the fifth to pupa, suggesting a wide distributing pattern with various signal intensities. Conclusion bmo-let-7 is stage- and tissue-specifically expressed in the silkworm. Although no signals were detected during embryonic development and first larval instar stages, the expression of bmo-let-7 was observed from the first molt, suggesting that it might also function at early larval stage of the silkworm. The

Characterization and expression patterns of let-7 microRNA in the silkworm (Bombyx mori).

Science.gov (United States)

Liu, Shiping; Xia, Qingyou; Zhao, Ping; Cheng, Tingcai; Hong, Kaili; Xiang, Zhonghuai

2007-07-25

lin-4 and let-7, the two founding members of heterochronic microRNA genes, are firstly confirmed in Caenorhabditis elegans to control the proper timing of developmental programs in a heterochronic pathway. let-7 has been thought to trigger the onset of adulthood across animal phyla. Ecdysone and Broad-Complex are required for the temporal expression of let-7 in Drosophila melanogaster. For a better understanding of the conservation and functions of let-7, we seek to explore how it is expressed in the silkworm (Bombyx mori). One member of let-7 family has been identified in silkworm computationally and experimentally. All known members of this family share the same nucleotides at ten positions within the mature sequences. Sequence logo and phylogenetic tree show that they are not only conserved but diversify to some extent among some species. The bmo-let-7 was very lowly expressed in ova harvested from newborn unmated female adult and in individuals from the first molt to the early third instar, highly expressed after the third molt, and the most abundant expression was observed after mounting, particularly after pupation. The expression levels were higher at the end of each instar and at the beginning of each molt than at other periods, coinciding with the pulse of ecdysone and BR-C as a whole. Using cultured ovary cell line, BmN-SWU1, we examined the effect of altered ecdysone levels on bmo-let-7 expression. The expression was also detected in various tissues of day 3 of the fifth instar and of from day 7 of the fifth to pupa, suggesting a wide distributing pattern with various signal intensities. bmo-let-7 is stage- and tissue-specifically expressed in the silkworm. Although no signals were detected during embryonic development and first larval instar stages, the expression of bmo-let-7 was observed from the first molt, suggesting that it might also function at early larval stage of the silkworm. The detailed expression profiles in the whole life cycle and

Can Better Mother-Daughter Relations Reduce the Chance of a Suicide Attempt among Latinas?

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Luis H. Zayas

2011-01-01

Full Text Available National surveys and other research on adolescent Latinas show that adolescent females have higher rates of suicidal ideation, planning, and attempts than other ethnic and racial minority youth. Internalizing behaviors and family conflicts are commonly associated with suicidality in research on adolescents. In the case of Latinas, we explore the connection between adolescent Hispanic cultural involvement, mother-adolescent mutuality, internalizing behaviors, and suicidality. This paper presents data from a study of 232 Latinas, some with a recent history of suicide attempts (n=122. The results show that higher adolescent Hispanic cultural involvement was associated with greater mother-daughter mutuality and thus led to reduction in the likelihood of suicide attempts. The relationship between mother-daughter mutuality and suicide attempts among Latinas is mediated by specific internalizing behaviors (withdrawn depressive. Our findings highlight the positive effect that Latino cultural values have in the relationship between Latina adolescent and their mothers and confirm the importance that internalizing behaviors and the mother-daughter relationship have for suicide attempters.

Mutagenic effect of radiations of various LET on Salmonella cells

International Nuclear Information System (INIS)

Kozubek, S.; Krasavin, E.A.; Amirtaev, K.G.; Tokarova, B.; Basha, S.G.

1989-01-01

Regularities of mutagenic effect of heavy charged particles of helium, deuterium ions and protons on various strains of Salmonella typhimurium were studied. Linear dose dependences of mutation frequency in the range of low doses were revealed. A conclusion was made that mutation process at low dose irradiation is determined in various teststrains of Salmonella typhimurium by certain premutation injuries. Quite a different picture is observed in mutation process in case of high dose irradiation where effect of inducible SOS-repair is distinctly manifested. Not only spectra of primary DNA injuries but probability of their fixation into mutation can change with the increase of LET. If fixation probability doesn't change with LET increase for replicative mutagenesis which make basis contribution to linear component of dose dependence of mutation frequency the probability of fixation is increased for reparative mutagenesis. It accounts for increase of values of relative genetic efficiency with LET increase. 7 refs.; 6 figs.; 1 tab

Coupling of replisome movement with nucleosome dynamics can contribute to the parent-daughter information transfer.

Science.gov (United States)

Bameta, Tripti; Das, Dibyendu; Padinhateeri, Ranjith

2018-06-01

Positioning of nucleosomes along the genomic DNA is crucial for many cellular processes that include gene regulation and higher order packaging of chromatin. The question of how nucleosome-positioning information from a parent chromatin gets transferred to the daughter chromatin is highly intriguing. Accounting for experimentally known coupling between replisome movement and nucleosome dynamics, we propose a model that can obtain de novo nucleosome assembly similar to what is observed in recent experiments. Simulating nucleosome dynamics during replication, we argue that short pausing of the replication fork, associated with nucleosome disassembly, can be a event crucial for communicating nucleosome positioning information from parent to daughter. We show that the interplay of timescales between nucleosome disassembly (τp) at the replication fork and nucleosome sliding behind the fork (τs) can give rise to a rich 'phase diagram' having different inherited patterns of nucleosome organization. Our model predicts that only when τp ≥ τs the daughter chromatin can inherit nucleosome positioning of the parent.

Concordance of mother-daughter diurnal cortisol production: Understanding the intergenerational transmission of risk for depression.

Science.gov (United States)

LeMoult, Joelle; Chen, Michael C; Foland-Ross, Lara C; Burley, Hannah W; Gotlib, Ian H

2015-05-01

A growing body of research is demonstrating concordance between mother and child diurnal cortisol production. In the context of maternal history of depression, intergenerational concordance of cortisol production could contribute to hypercortisolemia in children of depressed mothers, which has been shown to increase risk for MDD. The current study is the first to examine concordance in diurnal cortisol production between mothers with a history of depression and their never-depressed, but high-risk, children. We collected salivary cortisol across 2 days from mothers with (remitted; RMD) and without (CTL) a history of recurrent episodes of depression and their never-depressed daughters. As expected, RMD mothers and their daughters both exhibited higher cortisol production than did their CTL counterparts. Moreover, both across and within groups, mothers' and daughters' cortisol production were directly coupled. These findings suggest that there is an intergenerational concordance in cortisol dysregulation that may contribute to hypercortisolemia in girls at familial risk for depression. Copyright © 2015 Elsevier B.V. All rights reserved.

Maternal HIV serostatus, mother-daughter sexual risk communication and adolescent HIV risk beliefs and intentions.

Science.gov (United States)

Cederbaum, Julie A; Hutchinson, M Katherine; Duan, Lei; Jemmott, Loretta S

2013-09-01

Daughters of HIV-positive women are often exposed to the same factors that placed their mothers at risk. This cross-sectional study (N = 176 dyads) examined HIV status, parent-teen sexual risk communication (PTSRC), and daughters' abstinence and condom use beliefs and intentions. Maternal HIV status was not associated with PTSRC. Path analyses show that maternal depression was associated with PTSRC behavioral and normative beliefs; relationship satisfaction was associated with PTSRC normative and control beliefs. Control beliefs were solely predictive of maternal PTSRC intention. PTSRC was associated with adolescent behavioral and normative beliefs. Abstinence beliefs were associated with abstinence intentions; condom beliefs were associated with condom use intentions. Relationship satisfaction was associated with adolescent control beliefs about both abstinence and condom use. There is a need for interventions that help HIV-positive mothers recognize their daughter's HIV risk and provide them with relationship building and parent process skills to help reduce these risks.

Simultaneous production of buds on mother and daughter cells of Saccharomyces cerevisiae in the presence of hydroxyurea

Energy Technology Data Exchange (ETDEWEB)

Yamada, K; Michio, I

1979-12-01

Individual budding yeast cells, Saccharomyces cerevisiae, enclosed in small culture chambers were observed through two budding cycles to examine their behavior during growth and division. In the nutrient medium (YHG medium), the duration of the budding cycles was 77 minutes for mother cells and 90 minutes for daughter cells. Continuous exposure of cells to 16 or 32 mm hydroxyurea extended the duration of the cycles and increased the volume of cells, resulting in the formation of abnormally large and equal-sized mother-daughter pairs. Each cell of these pairs subsequently produced buds simultaneously. Stained cell nuclei showed simultaneous nuclear division. This synchronous budding on mother-daughter pairs was repeated in the next budding cycle. The coordination of growth with division is discussed in relation to these results.

Owning, letting and demanding second homes in Denmark

DEFF Research Database (Denmark)

Bloze, Gintautas; Skak, Morten

with administrative register data and presents estimations of the probability of owning a second home, the decision to let the second home and the number of let weeks per year. Also income elasticities for primary and second housing demand are estimated. We find a conventional monotonic increase in demand...... elasticities for primary housing demand for non-owners of second homes; however, owners of second homes have the highest income elasticity in the middle income group.......An increasing number of households consume housing beyond the primary home as owners of a second home. Economic studies of non-speculative demand for second homeownership are still scarce, and the present empirical study fills this gap to some extent. It is based on Danish survey data combined...

Mothers' factors associated with female genital mutilation in daughters in the Iraqi Kurdistan Region.

Science.gov (United States)

Shabila, Nazar P

2017-03-01

An important proactive factor for the continuation of female genital mutilation (FGM) is tradition and customs inherited in the family from mothers to daughters. Therefore, the aim of this study was to determine mothers' factors associated with the occurrence of FGM among their daughters. The datasets from the Iraq Multiple Indicator Cluster Survey 2011, on 5,184 women aged 15 to 49 years having at least one daughter, was used. Multivariate analysis based on a binary logistic regression model was applied. Mothers' age (adjusted odds ratio [aOR] = 8.18 at ages 25-34 years, aOR = 22.64 at ages 35-44 years, and aOR = 29.78 at ages 45-49 years, compared to the age group 15-24 years), educational level (aOR = 0.52 for primary education, aOR = 0.26 for secondary education, and aOR = 0.03 for higher education compared to uneducated), employment status (aOR = 0.55 for women having office work compared with unemployed), FGM status (aOR = 27.44 for circumcised mothers compared to uncircumcised), the governorate of residence (aOR = 18.73 for Suleimaniya and aOR = 33.23 for Erbil compared with Dohuk), and the wealth index of the household (aOR = 0.55 for richest group compared to the poorest) were significantly associated with the occurrence of FGM in daughters. Strategies aimed at preventing this harmful practice in the Iraqi Kurdistan Region should include female education and empowerment.

Recent trends in monitoring radon and daughter products in Indian uranium mines

International Nuclear Information System (INIS)

Khan, A.H.; Raghavayya, M.

1977-01-01

Uranium mining is of comparatively recent origin in India. In keeping with the ICRP (1959) and IAEA (1967) recommendations on the subject, the radiation practice in this country has been to monitor the mine air for radon. But the fact that radon daughter products are responsible for a major contribution to the radiation dose to the lungs and the comparative ease of correlating incidence of lung cancer with cumulative exposure to radon daughters (WLM), as demonstrated by epidemiologists, cannot be lost sight of. The results of a series of simultaneous measurements of radon, its decay products and their unattached fractions are presented. These measurements of radon have been carried out under different operational and passive conditions in mines. It has been observed that in the mine air, not only RaA but significant fractions of RaB and RaC too, exist in 'free state'. Wide variations have been observed in the unattached fractions with median values around 6% for RaA, 3% for RaB and 1% for RaC. The unattached daughter activities in the return air are maximum under passive conditions and show declining trend as the mining operations assume momentum causing increase in the aerosol concentrations. Relative merits of monitoring the mine air for radon and/or its decay products are also discussed

Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation.

Science.gov (United States)

Song, Juhyun; Oh, Yumi; Kim, Jong Youl; Cho, Kyoung Joo; Lee, Jong Eun

2016-11-01

Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

Generating Code with Polymorphic let: A Ballad of Value Restriction, Copying and Sharing

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Oleg Kiselyov

2017-02-01

Full Text Available Getting polymorphism and effects such as mutation to live together in the same language is a tale worth telling, under the recurring refrain of copying vs. sharing. We add new stanzas to the tale, about the ordeal to generate code with polymorphism and effects, and be sure it type-checks. Generating well-typed-by-construction polymorphic let-expressions is impossible in the Hindley-Milner type system: even the author believed that. The polymorphic-let generator turns out to exist. We present its derivation and the application for the lightweight implementation of quotation via a novel and unexpectedly simple source-to-source transformation to code-generating combinators. However, generating let-expressions with polymorphic functions demands more than even the relaxed value restriction can deliver. We need a new deal for let-polymorphism in ML. We conjecture the weaker restriction and implement it in a practically-useful code-generation library. Its formal justification is formulated as the research program.

Let-7i-Induced Atg4B Suppression Is Essential for Autophagy of Placental Trophoblast in Preeclampsia.

Science.gov (United States)

Xu, Yinyan; Huang, Xinyan; Xie, Juan; Chen, Yanni; Fu, Jing; Wang, Li

2017-09-01

Autophagy, identified as type II programmed cell death, has already been known to be involved in the pathophysiology of preeclampsia (PE), which is a gestational disease with high morbidity. The present study aims to investigate the functional role of let-7i, a miRNA, in trophoblastic autophagy. Placental tissue used in this study was collected from patients with severe preeclampsia (SPE) or normal pregnant women. A decreased level of let-7i was found in placenta of SPE. In addition, autophagic vacuoles were observed in SPE and the expression of microtubule associated protein 1 light chain 3 (LC3) II/I was elevated. In vitro, let-7i mimics suppressed the autophagic activities in human HTR-8/SVneo trophoblast cell line (HTR-8) and human placental choriocarcinoma cell line JEG-3, whereas let-7i inhibitor enhanced the activities. As a potential target of let-7i, autophagy-related 4B cysteine peptidase (Atg4B) had an increased expression level in SPE. As expected, the increased expression of Atg4B was negatively regulated by let-7i using dual luciferase reporter assay. Furthermore, these trophoblast-like cells transfected with the let-7i mimic or inhibitors resulted in a significant change of Atg4B in both mRNA and protein level. More importantly, Atg4B overexpression could partly reverse let-7i mimic-reduced LC3II/I levels; whereas Atg4B silencing partly attenuated let-7i inhibitor-induced the level of LC3II/I expression. Taken together, these findings suggest that let-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of PE. J. Cell. Physiol. 232: 2581-2589, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Perceptions of diet, physical activity, and obesity-related health among black daughter-mother pairs in Soweto, South Africa: a qualitative study

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Emily A. Phillips

2016-08-01

Full Text Available Abstract Background The prevalence of overweight and obesity is on the rise in South Africa, particularly among females living in urban environments. The purpose of this qualitative study was to explore the emic perspectives of black young adult daughter and mother pairs living in Soweto, South Africa on diet, physical activity, and obesity-related health within their social and cultural context. Methods Purposeful sampling was used to recruit daughters with a normal body mass index (BMI who have obese mothers. Individual semi-structured in-depth interviews were conducted with 17 daughters (age 24 years and 15 of their mothers in Soweto, South Africa. Interview questions related to: a eating and physical activity behaviors and perceptions, b perceptions of social and community level factors, c cultural beliefs about diet and body image, and d intergenerational relationships. Data were analyzed using four-phases of thematic analysis and the constant comparison approach. Results Daughters and mothers had similar ideas of the definition of healthy food and the importance of eating healthy, but mothers were more likely to report eating healthy because of their age, adverse health experiences, and a desire to live longer. Daughters and mothers engaged in physical activity for reasons related to weight maintenance and feeling better, but mothers reported being more likely to start exercising as a result of a health concern. Daughters and mothers had comparable views of what makes a person healthy. Daughters and mothers relied on each other for food purchasing and food preparation. Conclusion Daughters and mothers shared some similar perceptions of diet, physical activity, and health that were rooted in their daily life in Soweto. However, mothers generally reported being more likely to exhibit healthy eating and physical activity behaviors despite being obese. The mothers may have adopted these perceptions and behaviors later in life linked to ageing

High LET Radiation Amplifies Centrosome Overduplication Through a Pathway of γ-Tubulin Monoubiquitination

Energy Technology Data Exchange (ETDEWEB)

Shimada, Mikio [Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto (Japan); Hirayama, Ryoichi [Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Komatsu, Kenshi, E-mail: komatsu@house.rbc.kyoto-u.ac.jp [Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto (Japan)

2013-06-01

Purpose: Radiation induces centrosome overduplication, leading to mitotic catastrophe and tumorigenesis. Because mitotic catastrophe is one of the major tumor cell killing factors in high linear energy transfer (LET) radiation therapy and long-term survivors from such treatment have a potential risk of secondary tumors, we investigated LET dependence of radiation-induced centrosome overduplication and the underlying mechanism. Methods and Materials: Carbon and iron ion beams (13-200 keV/μm) and γ-rays (0.5 keV/μm) were used as radiation sources. To count centrosomes after IR exposure, human U2OS and mouse NIH3T3 cells were immunostained with antibodies of γ-tubulin and centrin 2. Similarly, Nbs1-, Brca1-, Ku70-, and DNA-PKcs-deficient mouse cells and their counterpart wild-type cells were used for measurement of centrosome overduplication. Results: The number of excess centrosome-containing cells at interphase and the resulting multipolar spindle at mitosis were amplified with increased LET, reaching a maximum level of 100 keV/μm, followed by sharp decrease in frequency. Interestingly, Ku70 and DNA-PKcs deficiencies marginally affected the induction of centrosome overduplication, whereas the cell killings were significantly enhanced. This was in contrast to observation that high LET radiation significantly enhanced frequencies of centrosome overduplication in Nbs1- and Brca1-deficient cells. Because NBS1/BRCA1 is implicated in monoubiquitination of γ-tubulin, we subsequently tested whether it is affected by high LET radiation. As a result, monoubiquitination of γ-tubulin was abolished in 48 to 72 hours after exposure to high LET radiation, although γ-ray exposure slightly decreased it 48 hours postirradiation and was restored to a normal level at 72 hours. Conclusions: High LET radiation significantly reduces NBS1/BRCA1-mediated monoubiquitination of γ-tubulin and amplifies centrosome overduplication with a peak at 100 keV/μm. In contrast, Ku70 and DNA

The health beliefs of mothers about preventing cervical cancer and their intention to recommend the Pap test to their daughters: a cross-sectional survey

Directory of Open Access Journals (Sweden)

Hae Won Kim

2016-05-01

Full Text Available Abstract Background Mothers have a primary role in the prevention of cervical cancer in Korea. This study aimed to determine the awareness and health beliefs of mothers about preventing cervical cancer in their daughters, their intention to recommend the Pap test to their daughters, and the factors influencing this intention. Methods A cross-sectional survey design was employed, and the study enrolled mothers (n = 1,581 of pubescent girls aged 13 to 18 years who were living nationwide in Korea. The six health-beliefs variables related to preventing cervical cancer in their daughters, awareness of the importance of cervical cancer prevention methods, and the intention to recommend the Pap test to daughters were investigated. The impacts of these health beliefs of the mothers and the sociodemographic factors influencing their intention to recommend the Pap test to their daughters were assessed using multiple logistic regression analysis. Results Almost one-quarter (23.7 % of the mothers had talked about the Pap test, 69.2 % were intending to recommend the Pap test to their daughters, and 38.5 % considered that the Pap test could be necessary if their daughters became sexually active. The significant health beliefs influencing the intention to recommend the Pap test were the perceived barriers [odds ratio (OR = 1.47, 95 % confidence interval (95 % CI = 1.03–2.11] and benefits (OR = 2.25, 95 % CI = 1.55–3.25. The significant sociodemographic factors of mothers were their education (OR = 1.52, 95 % CI = 1.08–2.13, their experience of talking about the Pap test with their daughters (OR = 2.11, 95 % CI = 1.23–3.64, their regularity of undergoing the Pap test themselves (OR = 1.98, 95 % CI = 1.30–3.03, and their age when they first underwent the Pap test (OR = 1.60, 95 % CI = 1.43–0.82. Conclusions The mothers perceived HPV vaccination as the most important of the five methods

Trust versus concerns-how parents reason when they accept HPV vaccination for their young daughter.

Science.gov (United States)

Gottvall, Maria; Grandahl, Maria; Höglund, Anna T; Larsson, Margareta; Stenhammar, Christina; Andrae, Bengt; Tydén, Tanja

2013-11-01

From spring of 2012, human papillomavirus (HPV) vaccine against cervical cancer is offered free of charge to all girls aged 10-12 years through a school-based vaccination programme in Sweden. The aim of this study was to explore how parents reason when they accept HPV vaccination for their young daughter and also their views on HPV-related information. Individual interviews with parents (n = 27) of 11-12-year-old girls. The interviews were recorded, transcribed verbatim, and analysed using thematic content analysis. Three themes emerged through the analysis: Trust versus concern, Responsibility to protect against severe disease, and Information about HPV and HPV vaccination is important. The parents expressed trust in recommendations from authorities and thought it was convenient with school-based vaccination. They believed that cervical cancer was a severe disease and felt a responsibility to protect their daughter from it. Some had certain concerns regarding side effects and vaccine safety, and wished for a dialogue with the school nurse to bridge the information gaps. Trust in the recommendations from authorities and a wish to protect their daughter from a severe disease outweighed concerns about side effects. A school-based vaccination programme is convenient for parents, and the school nurse has an important role in bridging information gaps. The findings from this qualitative study cannot be generalized; however, it can provide a better understanding of how parents might reason when they accept the HPV vaccination for their daughter.

Review of relative biological effectiveness dependence on linear energy transfer for low-LET radiations

International Nuclear Information System (INIS)

Hunter, Nezahat; Muirhead, Colin R

2009-01-01

Information on Japanese A-bomb survivors exposed to gamma radiation has been used to estimate cancer risks for the whole range of photon (x-rays) and electron energies which are commonly encountered by radiation workers in the work place or by patients and workers in diagnostic radiology. However, there is some uncertainty regarding the radiation effectiveness of various low-linear energy transfer (low-LET) radiations (x-rays, gamma radiation and electrons). In this paper we review information on the effectiveness of low-LET radiations on the basis of epidemiological and in vitro radiobiological studies. Data from various experimental studies for chromosome aberrations and cell transformation in human lymphocytes and from epidemiological studies of the Japanese A-bomb survivors, patients medically exposed to radiation for diagnostic and therapeutic procedures, and occupational exposures of nuclear workers are considered. On the basis of in vitro cellular radiobiology, there is considerable evidence that the relative biological effectiveness (RBE) of high-energy low-LET radiation (gamma radiation, electrons) is less than that of low-energy low-LET radiation (x-rays, betas). This is a factor of about 3 to 4 for 29 kVp x-rays (e.g. as in diagnostic radiation exposures of the female breast) and for tritium beta-rays (encountered in parts of the nuclear industry) relative to Co-60 gamma radiation and 2-5 MeV gamma-rays (as received by the Japanese A-bomb survivors). In epidemiological studies, although for thyroid and breast cancer there appears to be a small tendency for the excess relative risks to decrease as the radiation energy increases for low-LET radiations, it is not statistically feasible to draw any conclusion regarding an underlying dependence of cancer risk on LET for the nominally low-LET radiations. (review)

High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation

International Nuclear Information System (INIS)

Yamakawa, Nobuhiro; Takahashi, Akihisa; Mori, Eiichiro; Imai, Yuichiro; Ohnishi, Ken; Kirita, Tadaaki; Ohnishi, Takeo; Furusawa, Yoshiya

2008-01-01

Although mutations in the p53 gene can lead to resistance to radiotherapy, chemotherapy and thermotherapy, high linear energy transfer (LET) radiation induces apoptosis regardless of p53 gene status in cancer cells. The aim of this study was to clarify the mechanisms involved in high LET radiation-induced apoptosis. Human gingival cancer cells (Ca9-22 cells) containing a mutated p53 (mp53) gene were irradiated with X-rays, C-ion (13-100 KeV/μm), or Fe-ion beams (200 KeV/μm). Cellular sensitivities were determined using colony forming assays. Apoptosis was detected and quantified with Hoechst 33342 staining. The activity of Caspase-3 was analyzed with Western blotting and flow cytometry. Cells irradiated with high LET radiation showed a high sensitivity with a high frequency of apoptosis induction. The relative biological effectiveness (RBE) values for the surviving fraction and apoptosis induction increased in a LET-dependent manner. Both RBE curves reached a peak at 100 KeV/μm, and then decreased at values over 100 KeV/μm. When cells were irradiated with high LET radiation, Caspase-3 was cleaved and activated, leading to poly (ADP-ribose) polymerase (PARP) cleavage. In addition, Caspase-9 inhibitor suppressed Caspase-3 activation and apoptosis induction resulting from high LET radiation to a greater extent than Caspase-8 inhibitor. These results suggest that high LET radiation enhances apoptosis by activation of Caspase-3 through Caspase-9, even in the presence of mp53. (author)

Migration of uranium daughter radionuclides in natural sediments

International Nuclear Information System (INIS)

Colley, S.; Thomson, J.

1991-01-01

An irregular concentration/depth profile of uranium in deep-sea turbidities, previously elucidated, has been exploited to obtain in-situ effective diffusion coefficients for the long-lived members of the 238 U natural series. The findings are relevant to the assessment of deep-sea sediments as potential repositories for high-level radioactive waste, because waste actinides decay through the same chains of daughter radionuclides as natural actinides. This work was part of the CEC Mirage project-Second phase, Natural analogues research area

Lung pathology and exposure to radon daughters

International Nuclear Information System (INIS)

Saccomanno, G.

1980-01-01

The data presented suggest that the primary carcinogen of lung cancer in uranium miners is cigarette smoking because the incidence of lung cancer in noncigarette smokers is insignificant. In cigarette-smoking uranium miners, however, the incidence of cancer in those exposed to significant amounts of radon daughters is higher than in the smoking, nonmining population. This suggests that radon is an additive carcinogen if the lung has been injured by the cigarette-smoking carcinogen. Preliminary studies measuring DNA, T cells, and rosette inhibition immunological studies indicate closer monitoring of uranium miners' health during this occupation may be justified

Proteomics analysis for asymmetric inheritance of preexisting proteins between mother and daughter cells in budding yeast.

Science.gov (United States)

Okada, Mitsuhiro; Kusunoki, Shunta; Ishibashi, Yuko; Kito, Keiji

2017-06-01

In budding yeast, a mother cell can produce a finite number of daughter cells over its life. The accumulation of a variety of types of damaged components has an impact on the aging process. Asymmetrical inheritance during cell division causes these aberrant intracellular constituents to be retained in mother cells and prevents them from segregating to daughter cells. However, the understanding of asymmetrical inheritance of individual proteins that are damaged or old age, and their relevance to the aging process, has been limited. The aim of this study is to propose a proteomics strategy for asymmetrical inheritance of preexisting proteins between mother and daughter cells. During synchronous culture for one generation, newly synthesized proteins were labeled with stable isotope amino acids to discriminate preexisting proteins originally expressed in mother cells, followed by separation of mother and daughter cells using a conventional method based on biotin labeling. Isotope incorporation ratios for individual proteins were quantified using mass spectrometry. We successfully identified 21 proteins whose preexisting versions were asymmetrically inherited in mother cells, including plasma membrane transporter involved in the aging process and organelle-anchoring proteins related to the stress response to misfolded proteins. Thus, our approach would be useful for making catalog of asymmetrically inherited proteins. © 2017 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Leisure, gender, and kinship in dementia caregiving: psychological vulnerability of caregiving daughters with feelings of guilt.

Science.gov (United States)

Romero-Moreno, Rosa; Losada, Andrés; Marquez, María; Laidlaw, Ken; Fernández-Fernández, Virginia; Nogales-González, Celia; López, Javier

2014-07-01

The moderator role of guilt on the effect of leisure activities on dementia caregivers' depressive symptoms was analyzed, considering differences by kinship and guilt as a multidimensional construct. Participants were 351 caregivers (58.97% daughters, 10.54% sons, 19.66% wives, and 10.83% husbands). Measures included frequency of leisure activities, depressive symptoms, and guilt (total scale and 5 factors). A moderator role of guilt was found only for daughters. Specifically, significant interactions between guilt and frequency of leisure activities were found for the total scale and for the Factors 1 (guilt about doing wrong by the care recipient), 2 (guilt about failing to meet the challenges of caregiving), and 3 (guilt about self-care). For those daughters who reported lower levels of leisure activities, showing higher levels of guilt was associated with higher scores in depressive symptoms, whereas those with lower levels of guilt showed lower depressive symptoms scores. Feelings of guilt may have different consequences on caregivers' distress depending on caregivers' gender and kinship. Daughters with higher levels of guilt who do not engage in leisure activities may be especially vulnerable to suffering psychological distress. © The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Mother centrioles do a cartwheel to produce just one daughter.

Science.gov (United States)

Chen, Jieyan V; Megraw, Timothy L

2014-07-28

In this issue of Developmental Cell, Fong et al. (2014) present evidence for a model of centriole duplication whereby the cartwheel-the starting building block in centriole biogenesis-assembles within the lumen of the mother centriole before templating the daughter centriole to ensure a single duplication event per cell cycle. Copyright © 2014 Elsevier Inc. All rights reserved.

Sexual Risk among African American Girls: Psychopathology and Mother-Daughter Relationships

Science.gov (United States)

Donenberg, Geri R.; Emerson, Erin; Mackesy-Amiti, Mary Ellen

2011-01-01

Objective: To examine the associations among mental health problems, maternal monitoring and permissiveness, mother-daughter communication and attachment, and sexual behaviors among African American girls receiving outpatient psychiatric care. Youths with mental health problems report higher rates of HIV-risk behavior than do their peers, and…

LET spectrum measurements in Cr-39 PNTD with AFM

Energy Technology Data Exchange (ETDEWEB)

Johnson, Carl Edward [Los Alamos National Laboratory; De Witt, Joel M [OSU, PHYSICS; Benton, Eric R [OSU, PHYSICS; Yasuda, Nakahiro [NIRS, HIMAC; Benton, Eugene V [UNIV OF SAN FRANCISCO

2010-01-01

Energetic protons, neutrons, and heavy ions undergoing collisions with target nuclei of varying Z can produce residual heavy recoil fragments via intra-nuclear cascade/evaporation reactions. The particles produced in these non-elastic collisions generally have such extremely short range ({approx}< 10 {mu}m) that they cannot be directly observed by conventional detection methods including CR-39 plastic nuclear track detector (PNTD) that has been chemically etched for analysis by standard visible light microscopy. However, high-LET recoil fragments having range on the order of several cell diameters can be produced in tissue during radiotherapy using proton and carbon beams. We have developed a method to analyze short-range, high-LET tracks in CR-39 plastic nuclear track detector (PNTD) using short duration chemical etching ({approx}< 1 {mu}m) followed by automated atomic force microscope (AFM) scanning. The post-scan data processing used in this work was based on semi-automated matrix analysis opposed to traditional grey-scale image analysis. This method takes advantage of the 3-D data obtained via AFM to achieve robust discrimination of nuclear tracks from other features. Through automation of AFM scanning, sufficient AFM scan frames were obtained to attain an LET spectrum spanning the LET range from 200-1500 keV/{mu}m. In addition to our experiments, simulations were carried out with the Monte Carlo transport code, FLUKA. To demonstrate this method, CR-39 PNTD was exposed to the proton therapy beam at Loma Linda University Medical Center (LLUMC) at 60 and 230 MeV. Additionally, detectors were exposed to I GeV protons at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL). For these exposures CR-39 PNTD, Al and Cu target foils were used between detector layers.

LET spectrum measurements in Cr-39 PNTD with AFM

International Nuclear Information System (INIS)

Johnson, Carl Edward; DeWitt, Joel M.; Benton, Eric R.; Yasuda, Nakahiro; Benton, Eugene V.

2010-01-01

Energetic protons, neutrons, and heavy ions undergoing collisions with target nuclei of varying Z can produce residual heavy recoil fragments via intra-nuclear cascade/evaporation reactions. The particles produced in these non-elastic collisions generally have such extremely short range (∼< 10 μm) that they cannot be directly observed by conventional detection methods including CR-39 plastic nuclear track detector (PNTD) that has been chemically etched for analysis by standard visible light microscopy. However, high-LET recoil fragments having range on the order of several cell diameters can be produced in tissue during radiotherapy using proton and carbon beams. We have developed a method to analyze short-range, high-LET tracks in CR-39 plastic nuclear track detector (PNTD) using short duration chemical etching (∼< 1 μm) followed by automated atomic force microscope (AFM) scanning. The post-scan data processing used in this work was based on semi-automated matrix analysis opposed to traditional grey-scale image analysis. This method takes advantage of the 3-D data obtained via AFM to achieve robust discrimination of nuclear tracks from other features. Through automation of AFM scanning, sufficient AFM scan frames were obtained to attain an LET spectrum spanning the LET range from 200-1500 keV/μm. In addition to our experiments, simulations were carried out with the Monte Carlo transport code, FLUKA. To demonstrate this method, CR-39 PNTD was exposed to the proton therapy beam at Loma Linda University Medical Center (LLUMC) at 60 and 230 MeV. Additionally, detectors were exposed to I GeV protons at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL). For these exposures CR-39 PNTD, Al and Cu target foils were used between detector layers.

WE-H-BRA-05: Investigation of LET Spectral Dependence of the Biological Effects of Therapeutic Protons

Energy Technology Data Exchange (ETDEWEB)

Guan, F; Bronk, L; Kerr, M; Wang, X; Li, Y; Peeler, C; Sahoo, N; Patel, D; Mirkovic, D; Titt, U; Grosshans, D; Mohan, R [UT MD Anderson Cancer Center, Houston, TX (United States)

2016-06-15

Purpose: To investigate the dependence of biologic effect (BE) of therapeutic protons on LET spectra by comparing BEs with equal dose-averaged LET (LETd) derived from different LET spectra using high-throughput in vitro clonogenic survival assays. Methods: We used Geant4 to design the relevant experimental setups and perform the dose, LETd, and LET spectra calculations for spot-scanning protons. The clonogenic assay was performed using the H460 lung cancer cell line cultured in 96-well plates. In the first experimental setup (S1), cells were irradiated using 127.4 MeV protons with a 93.22 mm Lucite buildup resulting in a LETd value of 3.4 keV/µm in the cell layer. In the second experimental setup (S2), cells were irradiated by a combination of 127.4 MeV and 136.4 MeV protons with a 96.61 mm Lucite buildup. The LETd values in the cell layer were 11.4 keV/µm and 1.5 keV/µm respectively, but an average LETd of 3.4 keV/µm was obtained by adjusting the relative fluence of each beam. Ten discrete dose levels with 0.5 Gy increments were delivered. Results: In the two setups, the energies or LET spectra were different but resulted in identical LETd values. We quantified the dose contributions from high-LET (≥10 keV/µm, threshold determined by previous experiments) events in the LET spectra separately for these two setups as 3.2% and 10.5%. The biologic effects at each identical dose level yielded statistically significant different survival curves (extra sum-of-squares F-test, P<0.0001). The second setup with a higher contribution from high-LET events exhibited the higher biologic effect with a dose enhancement factor of 1.17±0.03 at 0.10 surviving fraction. Conclusion: The dose-averaged LET may not be an accurate indicator of the biological effects of protons. Detailed LET spectra may need to be considered explicitly to accurately quantify the biologic effects of protons. Funding Support: U19 CA021239-35, R21 CA187484-01 and MDACC-IRG.

Let the Right One In : Motion picture (2008)

OpenAIRE

Buhagiar, Celaine; Lauri Lucente, Gloria

2009-01-01

Twilight: A teenage girl risks everything when she falls in love with a vampire. Let the Right One In: Oskar, an overlooked and bullied boy, finds love and revenge through Eli, a beautiful but peculiar girl.

Relative biological effectiveness of alpha-particle emitters in vivo at low doses

International Nuclear Information System (INIS)

Howell, R.W.; Azure, M.T.; Narra, V.R.; Rao, D.V.

1994-01-01

The therapeutic potential of radionuclides that emit α particles, as well as their associated health hazards, have attracted considerable attention. The 224 Ra daughters 212 Pb and 212 Bi, by virtue of their radiation properties which involve emission of α and β particles in their decay to stable 208 Pb, have been proposed as candidates for radioimmunotherapy. Using mouse testes as the experimental model and testicular spermhead survival as the biological end point, the present work examines the radiotoxicity of 212 Pb and its daughters. When 212 Pb, in equilibrium with its daughters 212 Bi, 212 Po and 208 Tl, was administered directly into the testis, the dose required to achieve 37% survival (D 37 ) was 0.143 ± 0.014 Gy and the corresponding RBE of the mixed radiation field was 4.7 when compared to the D 37 for acute external 120 kVp X rays. This datum, in conjunction with our earlier results for 210 Po, was used to obtain an RBE-LET relationship for α particles emitted by tissue-incorporated radionuclides: RBE α = 4.8 - 6.1 x 10 -2 LET + 1.0 x 10 -3 LET 2 . Similarly, the dependence of RBE on α-particle energy E α was given by RBE α = 22 E α -0.73 . These relationships, based on in vivo experimental data, may be valuable in predicting biological effects of α-particle emitters. 46 refs., 6 figs

Comments upon 'basis of intake limits for radon and thoron daughters'

International Nuclear Information System (INIS)

Stewart, C.G.

1984-05-01

AECB consultative document C-78 proposes that the different types of exposure in uranium mines should be combined in such a fashion that the sum of the fractions contributing to annual dose (each fraction being the annual exposure of each type divided by the corresponding maximum permissible annual exposure) does not exceed unity. In order for this approach to be valid it is necessary for each of the demoninators to represent the same risk of mortality from malignancy, in this instance mortality from lung cancer where malignancy and mortality are very nearly equal. Document C-78 indicates that the limit of 50 mSv/a for whole body gamma irradiation and 4.7 WLM/a exposure to radon daughters are assumed to carry the same risk of mortality from malignancy. In the following document it is demonstrated that this assumption is not valid and consequently the current recommendations of C-78 for combining risk from gamma radiation and radon daughters are also not tenable

Narrative of a drug user's daughter: impact on family daily routine

Directory of Open Access Journals (Sweden)

Lúcia Margarete dos Reis

2017-08-01

Full Text Available Abstract Objective: To understand the repercussions of coexisting with the drug use in a family based on the daughter's narrative of a woman who is a multiple drugs user. Method: A case study with a family accessed in 2014, through the records of a Poison Control Center in the North of Paraná. It was used a semi-structured interview and field journal, and resources of thematic oral history to apprehend the story, from the question "How is/was for you and your family to live with a mother who is a drug user?” Results: The daughter's memories emphasized repercussions in the family context: long-term of living with drug abuse; absence or transience of the motherly figure, with rupture processes for homeless situation; cycle of parental disruption/forgiveness and continued presence and fatherly support. Final considerations: The narrative indicated a family that could be added to the process of rehabilitation and social reintegration of the female drug user.

The reduction of airborne radon daughter concentration by plateout on an air mixing fan

International Nuclear Information System (INIS)

Holub, R.F.; Droullard, R.F.; Ho, W.L.; Hopke, P.K.; Parsley, R.; Stukel, J.J.

1979-01-01

A series of experiments have been made in the U.S. Bureau of Mines Radon Test Chamber to study the effects of condensation nuclei, humidity and turbulence on the rapid deposition or plateout of radon daughter activity on the chamber walls. Under low humidity conditions the presence of a small fan reduced the working level by 41%. The activity was not deposited on the walls by the turbulent flow from the fan but actually became attached to the fan blades. High relative humidity (> 80%) totally inhibited this observed effect. A detailed mechanism for transport of the daughter species seems to be the critical factor in interpreting the experimental results. (author)

Cosmic ray LET spectra and doses on board Cosmos-2044 biosatellite

International Nuclear Information System (INIS)

Dudkin, V.E.; Kovalev, E.E.; Potapov, Yu.V.

1992-01-01

Results of the experiments on board Cosmos-2044 (Biosatellite 9) are presented. Various nuclear track detectors (NTD) (dielectric, AgCl-based, nuclear emulsions) were used to obtain the LET spectra inside and outside the satellite. The spectra from the different NTDs have proved to be in general agreement. The results of LET spectra calculations using two different models are also presented. The resultant LET distributions are used to calculate the absorbed and equivalent doses and the orbit-averaged quality factors (QF) of the cosmic rays (CR). Absorbed dose rates inside (∼ 20 g cm -2 shielding) and outside (1 g cm -2 ) the spacecraft, omitting electrons, were found to be 4.8 and 8.6 mrad d -1 , respectively, while the corresponding equivalent doses were 8.8 and 19.7 mrem d -1 . The effects of the flight parameters on the total fluence of, and on the dose from, the CR particles are analyzed. Integral dose distributions of the detected particles are also determined. The LET values which separate absorbed and equivalent doses into 50% intervals are estimated. The CR-39 dielectric NTD is shown to detect 20-30% of the absorbed dose and 60-70% of the equivalent dose in the Cosmos-2044 orbit. The influence of solar activity phase on the magnitude of the CR flux is discussed. (author)

Two decisive problems about Toward a Philosophy of the Act: the cleaved world and the attributes of the Being and the ethical act

Directory of Open Access Journals (Sweden)

Edson Soares Martins

2012-11-01

Full Text Available Toward a Philosophy of the Act, a fragmented and unfinished essay written by Mikhail Bakhtin, is one of the texts of the 1920s that better let us glimpse the subtle and complex dialogue established by the Russian philosopher with the philosophical field of his time, in particular through an exciting interpretive turn in Kant’s legacy. This paper seeks to discuss how the concept of an apartness between the world of life and the world of culture and the problems of both the attributes of Being and the open eventness of the responsible act are instrumentalized in a way that allows this philosophical turn, setting what accounts for Bakhtin’s first great contribution to occidental thinking.

Dosimetry and microdosimetry using LET spectrometer based on the track-etch detector: radiotherapy Bremsstrahlung beam, onboard aircraft radiation field

International Nuclear Information System (INIS)

Jadrnickova, I.; Spurny, F.

2006-01-01

The spectrometer of linear energy transfer (Let) based on the chemically etched poly-allyl-diglycol-carbonate (P.A.D.C.) track-etch detector was developed several years ago in our institute. This Let spectrometer enables determining Let of particles approximately from 10 to 700 keV/μm. From the Let spectra, dose characteristics can be calculated. The contribution presents the Let spectra and other dosimetric characteristics obtained onboard a commercial aircraft during more than 6 months long exposure and in the 18 MV radiotherapy Bremsstrahlung beam. (authors)

High-LET particle dosimetry in the ASTP-Biostack III: Zea mays experiment

International Nuclear Information System (INIS)

Peterson, D.D.; Benton, E.V.; Tran, M.; Yang, T.; Freeling, M.; Craise, L.; Tobias, C.A.

1977-01-01

High-LET particle hits in embryos of Zea mays (corn) seeds, flown as part of the ASTP-Biostack III, were determined via plastic nuclear track detectors. Based on etched particle-tracks measurements, 41 embryos were hit in seed layer 1 which contained 80 seeds, and 49 hits occurred in layer 2 which contained 79 seeds. The mean LET value and range of atomic numbers of recorded hits is, respectively, 210 +- 57 keV/μm and 9 approximately less than Z approximately less than 26. Detailed analysis of one particular seed showing marked growth anomalies revealed two hits in the central region of the embryo. These two hits had LET values in the region of 100 to 150 keV/μm, and Z less than approximately 20. (author)

Chemical protection from high LET radiation

International Nuclear Information System (INIS)

Ando, Koichi; Koike, Sachiko; Matsushita, Satoru; Kanai, Tatsuaki; Ohara, Hiroshi

1992-01-01

Radioprotection by WR151327 from high LET fast neutrons was investigated and compared with that from low LET radiation. Radiation damage in bone marrow, intestine, skin and leg length were all protected by a pretreatment with 400 mg/kg WR151327. Most prominent protection was observed for bone marrow, which gave a Dose Modifying Factor (DMF) of 2.2 against γ rays. Identical protection was observed between early and late radiation damage. WR151327 protected fast neutrons less efficiently than γ rays; 40% for bone marrow and 80% for skin leg. Pathological findings indicated that hyperplastic change in both dermis and epidermis associated with late skin shrinkage. Laser doppler flow-metry showed a good relationship between reduction of blood flow and late skin shrinkage. Irradiation of skin by heavy particle Carbon-12 indicated that skin shrinkage was modified by unirradiated surrounding normal tissues, which proposed a significant role of 'Volume Effect' in radiation damage. Tumor tissues were less protected by WR151327 than normal tissues. Dependence of radioprotection by WR151327 on tissue oxygen concentration is a probable reason to explain the difference between normal and tumor tissues. (author)

Velocardiofacial syndrome in father and daughter: What is the mechanism for the deletion 22(q11.2q11.2) in only the daughter?

Energy Technology Data Exchange (ETDEWEB)

Magenis, R.E.; Gunter, K.; Toth-Fejel, S. [Oregon Health Sciences Univ., Portland, OR (United States)] [and others

1994-09-01

E.G. had marked feeding difficulty noted at birth; the cause was determined to be a paralyzed palate. In 1992 chromosome studies were performed because of the provisional diagnosis of velocardiofacial syndrome, and a small interstitial deletion of chromosome 22 was found. Recently the family was seen in our Genetics Clinic. The father had unusual facial features shared by his daughter, a paralyzed upper lip and a history of repaired Tetralogy of Fallot. His chromosomes appeared normal. FISH studies were performed on the child`s peripheral blood using the ONCOR DiGeorge region probe (D22S75) and the deletion verified. However, the father`s chromosomes were not deleted for the ONCOR probe (D22S75) and probe DO832 sent to us by Peter Scambler. Skin cells were then obtained and no deletion was detected in a total of 66 cells examined using both probes. Several questions arise from these data: does the father have velocardiofacial syndrome? Does he have occult mosaicism? Does he have a molecular deletion not detected by the probes used? And was this deletion somehow {open_quotes}amplified{close_quotes} in his daughter?

Let-7a is a direct EWS-FLI-1 target implicated in Ewing's sarcoma development.

Directory of Open Access Journals (Sweden)

Claudio De Vito

Full Text Available Ewing's sarcoma family tumors (ESFT are the second most common bone malignancy in children and young adults, characterized by unique chromosomal translocations that in 85% of cases lead to expression of the EWS-FLI-1 fusion protein. EWS-FLI-1 functions as an aberrant transcription factor that can both induce and suppress members of its target gene repertoire. We have recently demonstrated that EWS-FLI-1 can alter microRNA (miRNA expression and that miRNA145 is a direct EWS-FLI-1 target whose suppression is implicated in ESFT development. Here, we use miRNA arrays to compare the global miRNA expression profile of human mesenchymal stem cells (MSC and ESFT cell lines, and show that ESFT display a distinct miRNA signature that includes induction of the oncogenic miRNA 17-92 cluster and repression of the tumor suppressor let-7 family. We demonstrate that direct repression of let-7a by EWS-FLI-1 participates in the tumorigenic potential of ESFT cells in vivo. The mechanism whereby let-7a expression regulates ESFT growth is shown to be mediated by its target gene HMGA2, as let-7a overexpression and HMGA2 repression both block ESFT cell tumorigenicity. Consistent with these observations, systemic delivery of synthetic let-7a into ESFT-bearing mice restored its expression in tumor cells, decreased HMGA2 expression levels and resulted in ESFT growth inhibition in vivo. Our observations provide evidence that deregulation of let-7a target gene expression participates in ESFT development and identify let-7a as promising new therapeutic target for one of the most aggressive pediatric malignancies.

Trust versus concerns—how parents reason when they accept HPV vaccination for their young daughter

Science.gov (United States)

Gottvall, Maria; Höglund, Anna T.; Larsson, Margareta; Stenhammar, Christina; Andrae, Bengt; Tydén, Tanja

2013-01-01

Background. From spring of 2012, human papillomavirus (HPV) vaccine against cervical cancer is offered free of charge to all girls aged 10–12 years through a school-based vaccination programme in Sweden. The aim of this study was to explore how parents reason when they accept HPV vaccination for their young daughter and also their views on HPV-related information. Methods. Individual interviews with parents (n = 27) of 11–12-year-old girls. The interviews were recorded, transcribed verbatim, and analysed using thematic content analysis. Results. Three themes emerged through the analysis: Trust versus concern, Responsibility to protect against severe disease, and Information about HPV and HPV vaccination is important. The parents expressed trust in recommendations from authorities and thought it was convenient with school-based vaccination. They believed that cervical cancer was a severe disease and felt a responsibility to protect their daughter from it. Some had certain concerns regarding side effects and vaccine safety, and wished for a dialogue with the school nurse to bridge the information gaps. Conclusions. Trust in the recommendations from authorities and a wish to protect their daughter from a severe disease outweighed concerns about side effects. A school-based vaccination programme is convenient for parents, and the school nurse has an important role in bridging information gaps. The findings from this qualitative study cannot be generalized; however, it can provide a better understanding of how parents might reason when they accept the HPV vaccination for their daughter. PMID:23777602

Radium and radium-daughter nuclides in carbonates: a brief overview of strategies for determining chronologies

International Nuclear Information System (INIS)

Schmidt, Sabine; Cochran, J. Kirk

2010-01-01

Radium isotopes have been used extensively to trace the movement of groundwater as well as oceanic water masses, but these radionuclides (and their daughters) are also useful chronometers for the determination of the time scales of other Earth and environmental processes. The purpose of this overview is to present the application of Ra and Ra daughters in the dating of carbonates. We show that the choice of dating method (decay of excess radionuclide or ingrowth of daughter) depends strongly on the parent/daughter activity ratios in the water in which the carbonate was precipitated. Thus freshly precipitated carbonates uniformly show excesses of 226 Ra relative to its parent 230 Th, and 226 Ra decay can provide ages of carbonates over Holocene time scales. In contrast, carbonates are precipitated in waters of greatly varying 210 Pb/ 226 Ra. Corals, deep-sea hydrothermal vent clams and the shelled cephalopod Nautilus live in waters with significant dissolved 210 Pb and all show excesses of 210 Pb in their carbonate. Bivalve molluscs from nearshore and coastal waters, and carbonates deposited from groundwater environments (e.g. travertines) in which 210 Pb is efficiently scavenged from solution, show deficiencies of 210 Pb relative to 226 Ra. In contrast, fish otoliths strongly discriminate against 210 Pb regardless of the environment in which the fish lives. Deficiencies of 228 Th relative to 228 Ra are common in all carbonates. Useful time ranges for the 210 Pb/ 226 Ra and 228 Th/ 228 Ra chronometers are ∼100 y and ∼10 y, respectively.

Eating behavior and psychological profile: associations between daughters with distinct eating disorders and their mothers.

Science.gov (United States)

Vázquez-Velázquez, Verónica; Kaufer-Horwitz, Martha; Méndez, Juan Pablo; García-García, Eduardo; Reidl-Martínez, Lucy María

2017-09-06

Associations of eating behaviors and psychological profile between mothers and daughters with eating disorders exist, but it is important to dissect the influence of the mother in each specific disorder since all eating disorders must be seen or treated not as one entity. The aim of the present study was to evaluate the association of eating behavior and psychological profile between mothers and daughters with different eating disorders and a control group. The study group included young girls with anorexia nervosa (AN, n = 30), bulimia nervosa (BN, n = 30), binge eating disorder (BED, n = 19), and a control group of women (Non-ED, n = 54) together with their mothers. BMI was calculated for dyads and Eating Disorder Inventory, Beck Depression Inventory, Beck Anxiety Inventory, Toronto Alexithymia Scale and Three-Factor Eating Questionnaire were applied. The differences between dyads were tested by Student's t test and Pearson's correlation was used to study the association between BMI, variables of eating behavior and psychological profile in each dyad. The study found significant inverse correlations between the AN dyad; some correlations between the BN dyad, and the highest positive correlations exist in BED dyad, especially in eating behavior. Finally, between the control dyads, low but significant correlations were found in the majority of cases. The study concluded that the associations between mothers and daughters with distinct eating disorders varied depending on the specific diagnosis of the daughter, indicating it is necessary to analyze them individually, given that there may be different implications for treatment.

Mouse fecal microbiome after exposure to high LET radiation

Data.gov (United States)

National Aeronautics and Space Administration — Space travel is associated with continuous low-dose-rate exposure to high Linear Energy Transfer (LET) radiation. Pathophysiological manifestations after low-dose...

Oxygen as a product of water radiolysis in high-LET tracks. II. Radiobiological implications

International Nuclear Information System (INIS)

Baverstock, K.F.; Burns, W.G.

1981-01-01

Consideration is given to the possibility that molecular oxygen generated in the tracks of energetic heavy ions is responsible for the reduction in oxygen enhancement ratio (OER) with increasing linear energy transfer (LET) observed for the loss of reproductive capacity caused by radiation in many cellular organisms. Yields of oxygen relationship of OER to LET for two organisms, Chlamydomonas reinhardii and Shigella flexneri, using a simple diffusion kinetic model for radiobiological action which takes account of the diffusion of oxygen after its formation. The results of these calculations show that the model accounts well for the shape of the OER vs. LET relationship

Seasonal variation of radon daughters concentrations in the atmosphere and in precipitation at the Japanese coast of the Sea of Japan

International Nuclear Information System (INIS)

Nishikawa, T.; Okabe, S.; Aoki, M.

1988-01-01

The atmospheric radon daughters concentration at Fukui in the Japanese coastal region of the Sea of Japan shows a seasonal variation whose high values appear in summer and low values in winter. On the other hand, the radon daughters concentration in precipitation at Fukui and that in the maritime atmosphere over the Sea of Japan are high in winter and low in summer. It is concluded from these phenomena that the greater part of the continental radon and its daughters are transported by seasonal winds from Siberia and China to Japan across the Sea of Japan in winter. However, when the air masses approach the shore, the cumulonimbus grows and the heavy snowfall scavenges out the radon daughters from the air masses in large quantities at the Japanese coastal region of the Sea of Japan. (author)

Analysis of mutagenic effects induced by carbon beams at different LET in a red yeast strain

International Nuclear Information System (INIS)

Sun Haining; Wang Jufang; Ma Shuang; Lu Dong; Wu Xin; Li Wenjian

2011-01-01

To evaluate inactive and mutagenic effects of carbon beam at different LET, the inactivation cross section and mutation cross section induced by carbon beams of different LET values were investigated in a red yeast strain Rhodotorula glutinis AY 91015. It was found that the maximum inactivation cross section of 4.37μm 2 , which was very close to the average nucleus cross section, was at LET of 120.0 keV/μm. The maximum mutation cross section was at LET of 96.0 keV/μm. Meanwhile, the highest mutagenicity of carbon ion was found around 58.2 keV/μm. It implied that the most efficient LET to induce mutation in survival yeasts was 58.2 keV/μm, which corresponded to energy of 35 MeV/u carbon beam. The most effective carbon beam to induce inactivation and mutation located at different energy region. (authors)

LET’s start new a LETS: Learning from a case-study investigation in Brno, Czech Republic

Directory of Open Access Journals (Sweden)

Lukáš Kala

2013-12-01

Full Text Available This paper brings information about the operation of RozLEŤSe, a LETS (Local Exchange Trading System network, based inBrno. LETS are parallel sustainable monetary systems, in which local community networks attempt to extricate themselves from the international economy by using their own currency. LETS is supposed to promote sustainable development by localising economic development. Although, there used to be several LETS group in the Czech Republic, all of them vanished during the first few years of the new millennium.  RozLEŤSe was built from the remains of former LETS groups. Hence, the aim of this study is to determine possible threats to the future existence of the group and evaluate its current operations. This research is a sociological case study investigation examining the socio-demographic characteristics, motivations and organisational functioning of the group. We point out some serious threats to the group (lack of supply, growth in negative credit, decrease in trust and offer possible solutions. 

Black mother's intention to vaccinate daughters against HPV: A mixed methods approach to identify opportunities for targeted communication.

Science.gov (United States)

Cunningham-Erves, Jennifer; Forbes, Laura; Ivankova, Nataliya; Mayo-Gamble, Tilicia; Kelly-Taylor, Kendria; Deakings, Jason

2018-03-24

The cervical cancer disparity continues to exist and has widened between Black and non-Hispanic White women. Human Papillomavirus (HPV) vaccines could potentially reduce this disparity, yet remain underused among Black female adolescents. We investigated psychosocial and cultural factors associated with Black mothers' intentions to vaccinate their daughters against HPV, and explored views toward a HPV vaccine mandate. In this quantitative dominant, mixed methods study, cross sectional surveys (n=237) and follow-up semi-structured interviews (n=9) were conducted with Black mothers of daughters. A 2-step logistic regression determined factors associated with Black mothers' intention. Thematic content analysis determined emerging themes. Perceived susceptibility (p=.044), perceived barriers (pHPV vaccination intentions. Follow-up interviews provided insight into factors influencing mothers' intentions. Mothers with low intentions did not perceive their daughter to be currently sexually active or in near future, thus, not at HPV risk. Pediatricians were identified as the most influential person on maternal decision-making if there was a pre-existing relationship. However, many mothers had not received a pediatricians' recommendation for their daughters. Barriers influencing mother's decision-making include knowledge, daughters' age, and mistrust in pharmaceutical companies and physicians. Mothers were not in favor of the HPV vaccine mandate. Findings demonstrate the need to develop and evaluate physician-led interventions on HPV and vaccine importance, and engage these mothers in intervention development to build trust between physicians, researchers, and Black mothers to improve HPV vaccine uptake in Black female adolescents. Published by Elsevier Inc.

Differences in Acculturation and Trajectories of Anxiety and Alcohol Consumption Among Latina Mothers and Daughters in South Florida.

Science.gov (United States)

Concha, Maritza; Sanchez, Mariana; Rojas, Patria; Villar, Maria Elena; De La Rosa, Mario

2016-08-01

This study documents generational differences in the impact of acculturation related factors on anxiety and alcohol use behaviors between adult Latino mothers and adult daughters. Findings indicate that for mothers (n = 144) and daughters (n = 149), self-reported anxiety levels decreased from baseline to follow up (p = 0.001). For mothers at follow up (n = 147), results indicate that affiliation to Latino culture is negatively associated with anxiety (p = 0.018). Conversely, employment and partner relationship stress are positively associated with anxiety (p = 0.05 and p = 0.016 respectively). In addition, self-reported anxiety is positively associated with alcohol intake (p = 0.002) and employment (p = 0.007). For daughters(n = 149), partner relationship stressors, anxiety and alcohol intake decreased significantly from baseline to follow up at a p = 0.01, p = 0.01, p = 0.05 respectively. In addition, for daughters at baseline (n = 160), affiliation to U.S. culture is positively associated with self-reported anxiety (p = 0.01). Employment is negatively associated with alcohol consumption (p = 0.027). At follow up (n = 152), daughters' partner relationship stress is positively associated with self- reported anxiety (p = 0.049). Findings in this study can be used to develop culturally appropriate interventions, support groups and individual therapy sessions by taking into consideration generational differences among Latino women.

Radon and radon daughters' concentration in spring and wells waters from Presidente Prudente: preliminary results

International Nuclear Information System (INIS)

Osorio, Ana Maria Araya; Saenz, Carlos Alberto Tello; Pereira, Luiz Augusto Stuani

2009-01-01

This work presents the preliminary results about the concentration of radon and radon daughters in wells and springs water from Presidente Prudente. Six water samples were studied: three from well-water, two from springs water and one from potable water. For the determination of α-activity the samples were placed inside plastic containers where the CR-39 tracks detectors were outside the water. The track density of α-particles were measured by using optical microscopy. The results show that one sample from well-water presented higher concentration of radon and radon daughters than the other samples. (author)

The equation x^py^q = z^r and groups that act freely on Λ-trees

OpenAIRE

Brady, N.; Ciobanu, Laura; Martino, A.; Rourke, S. O

2009-01-01

Let G be a group that acts freely on a Λ-tree, where Λ is an ordered abelian group, and let x,y,z be elements in G. We show that if xpyq = zr with integers p, q, r ≥ 4, then x, y and z commute. As a result, the one-relator groups with xpyq = zr as relator, are examples of hyperbolic and CAT( − 1) groups which do not act freely on any Λ-tree.

Diasporic Authenticity Assertions: Analysis of Amy Tan’s The Bonesetter’s Daughter

Directory of Open Access Journals (Sweden)

Naeimeh Tabatabaei Lotfi

2015-07-01

Full Text Available This essay is an attempt to examine the active interaction of history and memory, in formulation of a diasporic authentic picture of past, in Amy Tan’s The Bonesetter’s Daughter (2001. Amongst discursive disciplines, memory and history perform vitally, in picturing past; both attempt to reproduce events, by emblematic narrative acts. However, their erratic quality endorses the existence of counter- stories that endangers displaying a homogeneous past. Among miscellaneous categories of memories, autobiographical memory asserts to obtain an authentic presentation, but as any other forms of accounts, it exhibits an imprecise fictional image. This psychological alleviation ensures the future mental integrity of trauma victims. In memory narratives, the contingent temperament of power network and continual formulation of resisting frameworks might be explored. Tan’s diasporic assertion of authenticity, as a migrant writer, amalgamated with employment of fantasy is to obtain a shared diasporic identity, among her characters, although personal accounts of characters undergo an extensive amount of contingency. The newly forged identity is collective in nature and defies the geographical and temporal borders and grants a humane picture rather than a diasporic one; an identity that is established to venerate the cardinal role of personal memory, in endowing legitimate truth.

Depth-Dose and LET Distributions of Antiproton Beams in Various Target Materials

DEFF Research Database (Denmark)

Herrmann, Rochus; Olsen, Sune; Petersen, Jørgen B.B.

the annihilation process. Materials We have investigated the impact of substituting the target material on  the depth-dose distribution of pristine and  spread out antiproton beams using the FLUKA Monte Carlo transport program. Classical ICRP targets are compared to water phantoms. In addition, track average...... unrestricted LET is calculated for all configurations. Finally, we investigate which concentrations of gadolinium and boron are needed in a water target in order to observe a significant change in the antiproton depth-dose distribution.  Results Results indicate, that there is no significant change...... in the depth-dose distribution and average LET when substituting the materials. Adding boron and gadolinium up to concentrations of 1 per 1000 atoms to a water phantom, did not change the depth-dose profile nor the average LET. Conclusions  According to our FLUKA calculations, antiproton neutron capture...

Mean size among the particles of short-lived radon daughter products in the atmosphere

International Nuclear Information System (INIS)

Nakatani, S.

1980-01-01

The diffusion-battery method is used to classify the radioactive particles according to their sizes. The diffusion coefficient is determined from the fractional penetration of the particles through the battery. Particle radii are derived from the diffusion coefficients with the Stokes-Cunningham-Millikan formula. At the exit and entrance of the battery, individual concentrations of radon daughter products 218 Po, 214 Pb, 214 Bi are determined. Thus the mean sizes of individual radon daughters can be obtained from the fractional penetration of individual nuclides through the diffusion battery. Despite large statistical fluctuations the mean size of 214 Bi is always shifted toward the larger size region as compared with those of other radionuclides

Multivariate signal processing in measurements of radon and radon daughters in air

International Nuclear Information System (INIS)

Urbanski, P.; Machaj, B.

2000-01-01

Extensive measurements of radon and radon daughters concentration gauge in a radon chamber were carried out. Count rate 'spectra' against time at the output of radiation detectors were measured and registered. The count rate spectra were then processed employing Principal Component Regression (PCR). A root mean square error of the count rate was estimated. It was found that PCR processing removes a great part of count rate random fluctuations originating from the radiation statistics that results in a decrease of count rate random error. The root mean square error of count rate in a radon daughter monitor is about 3 times lower, which is equivalent to the error of the gauge with a 9 times higher air flow rate if no PCR processing is used. In case of the radon concentration gauge the increase of sensitivity is even higher and amounts to 5 times. (author)

Adult daughters providing post-stroke care to a parent: a qualitative study of the impact that role overload has on lifestyle, participation and family relationships.

Science.gov (United States)

Bastawrous, Marina; Gignac, Monique A; Kapral, Moira K; Cameron, Jill I

2015-06-01

To qualitatively explore daughters' experiences with and response to holding multiple roles while providing post-stroke care to a parent. Qualitative study using a descriptive approach. Semi-structured interviewing was used. Interviews were recorded, transcribed and analyzed to develop themes. General community of a metropolitan city. Twenty-three adult daughters caring for a community-dwelling parent who had suffered a stroke. Not applicable. Not applicable. Role overload is a salient issue for daughter caregivers. This overload is best captured by the analogy of "juggling" multiple role demands and responsibilities. Two key themes suggest that role overload resulting from parent care affects daughters': 1) valued relationships (e.g. challenges develop in their relationship with children and partner); and 2) ability to participate in valued activities (e.g. reduced involvement in leisure activities and restricted employment). Future support efforts should help daughters manage the caregiving role in light of other responsibilities. This can mitigate overload-related strain in valued relationships and decreased participation in valued activities, thereby contributing to better health and well-being for daughter caregivers. © The Author(s) 2014.

Internal high linear energy transfer (LET) targeted radiotherapy for cancer

International Nuclear Information System (INIS)

Allen, Barry J

2006-01-01

High linear energy transfer (LET) radiation for internal targeted therapy has been a long time coming on to the medical therapy scene. While fundamental principles were established many decades ago, the clinical implementation has been slow. Localized neutron capture therapy, and more recently systemic targeted alpha therapy, are at the clinical trial stage. What are the attributes of these therapies that have led a band of scientists and clinicians to dedicate so much of their careers? High LET means high energy density, causing double strand breaks in DNA, and short-range radiation, sparing adjacent normal tissues. This targeted approach complements conventional radiotherapy and chemotherapy. Such therapies fail on several fronts. Foremost is the complete lack of progress for the control of primary GBM, the holy grail for cancer therapies. Next is the inability to regress metastatic cancer on a systemic basis. This has been the task of chemotherapy, but palliation is the major application. Finally, there is the inability to inhibit the development of lethal metastatic cancer after successful treatment of the primary cancer. This review charts, from an Australian perspective, the developing role of local and systemic high LET, internal radiation therapy. (review)

Expression of hsa Let-7a MicroRNA of Macrophages Infected by Leishmania Major

Directory of Open Access Journals (Sweden)

Nooshin Hashemi

2016-10-01

Full Text Available Leishmaniasis is a vector-born disease caused by species of the genus Leishmania and is transmitted from host to host through the bite of an infected sandfly. MicroRNAs (miRNAs are non-coding small RNAs with 22-nucleotide length. They are involved in some biological and cellular processes. We aimed to evaluate the expression of let-7a in human macrophages miRNA when are infected by Leishmania major. We also evaluated the impact of Leishmania major infection on the expression of let-7a at two different times, 24 and 48 hours, after infection. Blood samples were collected from ten healthy volunteers with no history of leishmaniasis. Development of macrophages from peripheral monocytes and infection with stationary phase of Leishmania major promastigotes were done through serial cultures under 5% CO2 environment and 37C. To measure the expression levels of let-7a real-time PCR was performed with specific related primers using the SYBR® Green master mix Kit™. The real-time PCR showed let-7a was expressed in cells infected with parasites after 24 and 48h post-infection. Comparison of let-7a miRNA expression after 24 and 48 h revealed that let-7a miRNAs were down-regulated at 48 h post-infection more than 24h after infection. The results of this study suggest that according to the main function of miRNA in repression of mRNA translation it could be possible to manipulate host cells in order to alter miRNA levels and regulate macrophage functions after establishment of intracellular parasites such as Leishmania.

Simulation of radon short lived decay daughters' inhalation using the lung compartmental model

International Nuclear Information System (INIS)

Tomulescu, Vlad C.

2002-01-01

Radon and its short-lived decay daughters are the main source of radiation on natural ways for population. The radon gas, released from soil, water or construction materials is producing by radioactive decay the following solid daughters: Po-218, Bi-214, Pb-214, and Po-214, which can attach to aerosols, and consequently penetrate the organism by inhalation. The human respiratory tract can be approximated by aid of a compartment model that takes into account the different anatomical structures exposed to contamination and irradiation, as well as the respective physiological processes. This model is associated to a mathematical equation system that describes the behavior of the radioactive material inside the body. The results represent the dose equivalent on different organs and tissues, as a function of subject and the activity performed in contaminating environment. (author)

Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7.

Science.gov (United States)

Coleman, Leon G; Zou, Jian; Crews, Fulton T

2017-01-25

Toll-like receptor (TLR) signaling is emerging as an important component of neurodegeneration. TLR7 senses viral RNA and certain endogenous miRNAs to initiate innate immune responses leading to neurodegeneration. Alcoholism is associated with hippocampal degeneration, with preclinical studies linking ethanol-induced neurodegeneration with central innate immune induction and TLR activation. The endogenous miRNA let-7b binds TLR7 to cause neurodegeneration. TLR7 and other immune markers were assessed in postmortem human hippocampal tissue that was obtained from the New South Wales Tissue Bank. Rat hippocampal-entorhinal cortex (HEC) slice culture was used to assess specific effects of ethanol on TLR7, let-7b, and microvesicles. We report here that hippocampal tissue from postmortem human alcoholic brains shows increased expression of TLR7 and increased microglial activation. Using HEC slice culture, we found that ethanol induces TLR7 and let-7b expression. Ethanol caused TLR7-associated neuroimmune gene induction and initiated the release let-7b in microvesicles (MVs), enhancing TLR7-mediated neurotoxicity. Further, ethanol increased let-7b binding to the danger signaling molecule high mobility group box-1 (HMGB1) in MVs, while reducing let-7 binding to classical chaperone protein argonaute (Ago2). Flow cytometric analysis of MVs from HEC media and analysis of MVs from brain cell culture lines found that microglia were the primary source of let-7b and HMGB1-containing MVs. Our results identify that ethanol induces neuroimmune pathology involving the release of let-7b/HMGB1 complexes in microglia-derived microvesicles. This contributes to hippocampal neurodegeneration and may play a role in the pathology of alcoholism.

Daughters Taking Over the Family Business : A Gender Analysis

OpenAIRE

Constantinidis, Christina; Cornet, Annie

2008-01-01

This paper investigates the succession process as perceived and lived by daughters taking over the family business, with a gender perspective. Despite the rich literature on the succession process in family firms, few studies use a gender approach, though an increasing number of ventures are launched, taken over and managed by women, largely contributing to the economic development. In line with Dumas (1998), Barbot et al. (2005) and Vera & Dean (2005), our research aims at analyzing the succ...

Perceptions of Help Given to Healthy Older Mothers by Adult Daughters: Ways of Initiating Help and Types of Help Given

Science.gov (United States)

Martini, Tanya S.; Grusec, Joan E.; Bernardini, Silvia Cortese

2003-01-01

Older mother-adult daughter dyads (N = 43) addressed two issues pertaining to the ways in which help is initiated (offered, requested, and imposed help) and type of help given (instrumental help, advice, and emotional support) a) mothers' reasoning about these aspects of help, and b) daughters' understanding of mothers' feelings. Both groups noted…

Misfits of War: First World War Nurses in the Daughters of Mars by Thomas Keneally

Directory of Open Access Journals (Sweden)

Branach-Kallas Anna

2017-12-01

Full Text Available The article is an analysis of the representation of Australian nurses in Thomas Keneally 2012 First World War novel, The Daughters of Mars. Inspired by rigorous research, Keneally fictionalizes the lives of two nursing sisters in the Middle East, on a hospital ship in the Dardanelles, as well as in hospitals and casualty clearing stations on the Western Front. His novel thus reclaims an important facet of the medical history of the First World War. The author of the article situates her analysis in the context of historical research on the First World War and the Australian Anzac myth, illuminating the specifically Australian elements in Keneally’s portrait of the Durance sisters. She demonstrates that The Daughters of Mars celebrates the achievements of “Anzac girls”, negotiating a place for them in the culture of commemoration. Yet, at the same time, Keneally attempts to include his female protagonists in the “manly” world of Anzac values, privileging heroism over victimization. Consequently, they become “misfits of war”, eagerly accepting imperial and nationalist ideologies. Thus, in a way characteristic of Australian First World War literature, The Daughters of Mars fuses the tropes of affirmation and desolation.

Differences in acculturation and trajectories of anxiety and alcohol consumption among Latino mothers and daughters in South Florida

Science.gov (United States)

Concha, Maritza; Sanchez, Mariana; Rojas, Patria; Villar, Maria Elena; De La Rosa, Mario

2015-01-01

This study documents generational differences in the impact of acculturation related factors on anxiety and alcohol use behaviors between adult Latino mothers and adult daughters. Findings indicate that for mothers (n=144) and daughters (n=149), self-reported anxiety levels decreased from baseline to follow up (p=.001). For mothers at follow up (n=147), results indicate that affiliation to Latino culture is negatively associated with anxiety (p= .018). Conversely, employment and partner relationship stress are positively associated with anxiety (p = .05 and p = .016 respectively). In addition, self-reported anxiety is positively associated with alcohol intake (p = .002) and employment (p = .007). For daughters(n=149), partner relationship stressors, anxiety and alcohol intake decreased significantly from baseline to follow up at a p = .01, p = .01 , p = .05 respectively. In addition, for daughters at baseline (n=160), affiliation to U.S. culture is positively associated with self-reported anxiety (p = .01). Employment is negatively associated with alcohol consumption (p = .027). At follow up (n=152), daughters’ partner relationship stress is positively associated with self- reported anxiety (p = .049). Findings in this study can be used to develop culturally appropriate interventions, support groups and individual therapy sessions by taking into consideration generational differences among Latino women. PMID:26399773

When Fairness Clashes with Personal Autonomy and Parental Authority: A Comparison of Daughters' and Mothers' Reasoning in Two Cultural Contexts in Turkey.

Science.gov (United States)

Acar, Melike

2017-01-01

The author examined religious and secular daughters' and mothers' reasoning about personal autonomy, maternal authority, and moral concepts in family decision-making situations in urban Turkey. Sixty-eight daughters and 34 mothers were individually interviewed about decision-making autonomy in general issues and hypothetical daughter-mother conflicts. Results indicated participants regardless of their family status and religious background assigned more decision-making autonomy to mothers when evaluating general issues. Analysis of controversial issues as hypothetical conflicts indicated that daughters and mothers do not hold unitary social judgments about the social world that were always consistent with the norms of their community and family status. There were some religious background differences in evaluations of some conflict stories as a function of whether they evaluated the choices as moral, conventional, personal, and prudential matters. Although secular and religious participants conceptualized daughters and mothers in relational terms rather than characterizing the relations and social issues by harmony, obedience to authority, and acceptance of norms findings suggested that secular women evaluated the hypothetical adolescent-mother conflicts more consistently when the issue entails violation of a moral principle such as justice, fairness, and well-being of the other.

Behaviour of 222Rn and its daughter products in open atmosphere

International Nuclear Information System (INIS)

Ondo-Estok, D.; Holy, K.; Stanys, T.; Polaskova, A.; Hola, O.

2003-01-01

In this contribution the influence of the meteorological conditions on activity concentrations of the outdoor 222 Rn and its daughter products is discussed in detail. In addition, the correlation between concentrations of measured radionuclides is studied and empirical relations for concentrations of radon daughter products are presented. he courses of the activity concentrations of 222 Rn and its short-lived decay products in the outdoor atmosphere are very similar even in some details. The average equilibrium factor F determined on the basis of our measurements in the outdoor atmosphere is approximately about 20 % lower than the value F recommended by UNSCEAR 1996 for the open air (F = 0,7). The obtained nonlinear relations between radon and its decay products reduce the applications of decay products in the atmospheric studies on one hand but on the other hand they can be useful at the calculation of the equilibrium equivalent radon concentration with the aim to determine the effective radon dose on the basis of the measurements of its activity concentrations only. (authors)

Let-7i attenuates human brain microvascular endothelial cell damage in oxygen glucose deprivation model by decreasing toll-like receptor 4 expression.

Science.gov (United States)

Xiang, Wei; Tian, Canhui; Peng, Shunli; Zhou, Liang; Pan, Suyue; Deng, Zhen

2017-11-04

The let-7 family of microRNAs (miRNAs) plays an important role on endothelial cell function. However, there have been few studies on their role under ischemic conditions. In this study, we demonstrate that let-7i, belonging to the let-7 family, rescues human brain microvascular endothelial cells (HBMECs) in an oxygen-glucose deprivation (OGD) model. Our data show that the expression of let-7 family miRNAs was downregulated after OGD. Overexpression of let-7i significantly alleviated cell death and improved survival of OGD-treated HBMECs. Let-7i also protected permeability in an in vitro blood brain barrier (BBB) model. Further, let-7i downregulated the expression of toll-like receptor 4 (TLR4), an inflammation trigger. Moreover, overexpression of let-7i decreased matrix metallopeptidase 9 (MMP9) and inducible nitric oxide synthase (iNOS) expression under OGD. Upon silencing TLR4 expression in HBMECs, the anti-inflammatory effect of let-7i was abolished. Our research suggests that let-7i promotes OGD-induced inflammation via downregulating TLR4 expression. Copyright © 2017 Elsevier Inc. All rights reserved.

Ionization chambers for LET determination

DEFF Research Database (Denmark)

Kaiser, Franz-Joachim; Bassler, Niels; Tölli, Heikki

2010-01-01

resolution and high sensitivity are necessary. For exact dosimetry which is done using ionization chambers (ICs), the recombination taking place in the IC has to be known. Up to now, recombination is corrected phenomenologically and more practical approaches are currently used. Nevertheless, Jaff´e's theory...... of columnar recombination was designed to model the detector efficiency of an ionization chamber. Here, we have shown that despite the approximations and simplification made, the theory is correct for the LETs typically found in clinical radiotherapy employing particles from protons to carbon ions...

Radon dosimetry: a review of radon and radon daughter exposure conditions in dwellings and other structures

International Nuclear Information System (INIS)

Ryan, M.T.; Goldsmith, W.A.; Poston, J.W.; Haywood, F.F.; Witherspoon, J.P.

1983-07-01

Within the past few years several situations have been brought to light which indicate an increased radiation exposure of certain segments of the general population caused by human activities. The most widely publicized activities are those associated with the mining and milling of uranium in the western United States, the phosphate industry in Florida, and those potential problems represented by former Manhattan Engineer District sites. One of the primary problems involves exposure to radon and radon daughters which are released from large waste piles or, in some cases, evolve from backfill and construction materials used in homes, schools, and other buildings. This report presents a review of the available data on radon and radon daughter concentrations in dwellings and other structures. The primary objectives were to compile and tabulate pertinent radon exposure data and to prepare a statistical summary of the data which will be useful in the prediction of normal levels of radon and radon daughter concentrations in these structures. In addition, other parameters associated with radon exposure conditions are presented and discussed

A method for radiobiological investigations in radiation fields with different LET and high dose rates

International Nuclear Information System (INIS)

Grundler, W.

1976-01-01

For investigations: 1. Performed in the field of radiobiology with different LET-radiation and a relatively high background dose rate of one component (e.g. investigations with fast and intermediate reactor neutrons) 2. Concerning radiation risk studies within a wide range 3. Of irradiations, covering a long time period (up to 100 days) a test system is necessary which on the one hand makes it possible to analyze the influence of different LET radiation and secondly shows a relative radiation resistant behaviour and allows a simple cell cycle regulation. A survey is given upon the installed device of a simple cell observation method, the biological test system used and the analysis of effects caused by dose, repair and LET. It is possible to analyze the behaviour of the nonsurvival cells and to demonstrate different reactions of the test parameters to the radiation of different LET. (author)

Psychological aspects of idiopathic scoliosis: the specificity of the mother-daughter relationship

Directory of Open Access Journals (Sweden)

Galina V. Pyatakova

2016-12-01

Conclusion: General and specific characteristics of the mother-daughter relationship in families of adolescent girls with idiopathic scoliosis and families of healthy adolescent girls were revealed. In the context of complex surgical treatment, preventive measures are necessary to address psychological difficulties in adolescent patients with idiopathic scoliosis.

Hispanic Mothers' Beliefs Regarding HPV Vaccine Series Completion in Their Adolescent Daughters

Science.gov (United States)

Roncancio, A. M.; Ward, K. K.; Carmack, C. C.; Muñoz, B. T.; Cribbs, F. L.

2017-01-01

Rates of human papillomavirus (HPV) vaccine series completion among adolescent Hispanic females in Texas in 2014 (~39%) lag behind the Healthy People 2020 goal (80%). This qualitative study identifies Hispanic mothers' salient behavioral, normative and control beliefs regarding having their adolescent daughters complete the vaccine series.…

Effects of estrogen and gender on cataractogenesis induced by high-LET radiation

International Nuclear Information System (INIS)

Henderson, M.A.; Rusek, A.; Valluri, S.; Garrett, J.; Lopez, J.; Caperell-Grant, A.; Mendonca, M.; Bigsby, R.; Dynlacht, J.

2010-01-01

Planning for long-duration manned lunar and interplanetary missions requires an understanding of radiation-induced cataractogenesis. Previously, it was demonstrated that low-linear energy transfer (LET) irradiation with 10 Gy of 60 Co γ rays resulted in an increased incidence of cataracts in male rats compared to female rats. This gender difference was not due to differences in estrogen, since male rats treated with the major secreted estrogen 17-β-estradiol (E2) showed an identical increase compared to untreated males. We now compare the incidence and rate of progression of cataracts induced by high-LET radiation in male and female Sprague-Dawley rats. Rats received a single dose of 1 Gy of 600 MeV 56 Fe ions. Lens opacification was measured at 2-4 week intervals with a slit lamp. The incidence and rate of progression of radiation-induced cataracts was significantly increased in the animals in which estrogen was available from endogenous or exogenous sources. Male rats with E2 capsules implanted had significantly higher rates of progression compared to male rats with empty capsules implanted (P = 0.025) but not compared to the intact female rats. These results contrast with data obtained after low-LET irradiation and suggest the possibility that the different types of damage caused by high- and low-LET radiation may be influenced differentially by steroid sex hormones.

Indoor concentrations of radon 222 and its daughters: sources, range, and environmental influences

International Nuclear Information System (INIS)

Nero, A.V. Jr.

1985-04-01

The author here reviews what is presently known about factors affecting indoor concentrations of radon 222 and its daughters. In US single-family homes, radon concentrations are found to average about 1.5 pCi/1, but substantially higher concentrations occur frequently: perhaps a million US homes have concentrations exceeding 8 pCi/1 (from which occupants receive radiation doses comparable to those now experienced by uranium miners). The major contributor to indoor radon is ordinary soil underlying homes, with this radon being transported indoors primarily by the slight depressurization that occurs toward the bottom of a house interior (due to indoor-outdoor temperature differences and winds). Water from underground sources contributes significantly in a minority of cases, primarily residences with private wells, with public water supplies contributing only a few percent of indoor radon, even when drawn from wells. The strong variability in indoor concentrations is associated primarily with variability in the amount of radon entering homes from these various sources, and secondarily with differences in ventilation rates. However, for a given entry rate, the ventilation rate is the key determinant of indoor concentrations. Human doses are also influenced strongly by the chemical behavior of the daughters (i.e., decay products of radon), and considerable progress has been made recently in investigating a major aspect of this behavior, i.e., the manner in which daughters attach to airborne particles, to walls, and - indeed - to the lining of the lung itself, where the key radiation dose occurs

A review of instrumentation for determination of radon and its daughters concentration

International Nuclear Information System (INIS)

Kurosawa, Ryuhei

1989-01-01

The aim of the review is to provide the aid for selection and understanding of the radon and its daughters measurement techniques which have been developed for radiation protection activities in various environments such as working of living environment. The practical purpose of the measurement for surveillance in environmental situation is the dose estimation for the public due to the inhalation of natural occurring radioactive materials. The techniques for the determination of radon and thoron concentratin by the active methods with the grab and continuous sampling, and also structures of radon monitors of various passive type are described. Explanation was made on the typical instruments for the determination of the potential alpha energy concentration (PAEC) of radon daughters by the various detecting systems such as solid state detector, and for the estimation of integrated PAEC in the various environments by the PAEC monitors using the cellulose nitrate film or TLD elements (author)

LET effect on irradiation of hydroxyphthal imide in alcohol solutions

International Nuclear Information System (INIS)

Nakagawa, S.; Murakami, T.

2005-01-01

Hydroxyphthalimide(C 6 H 4 (CO) 2 -NOH) was irradiated with C ion (290MeV/u) in isopropyl alcohol, methanol, ethanol, and acetonitrile. LET was 13.2 and 26.5 keV/m. Dose was 5 and 10 kGy. A little amount of phthalimide was produced. The G value of the production of phthalimide by ion irradiation was less than that by -irradiation except for in methanol. In methanol solution, the production rate of phthalimide increased with increasing the value of LET. The amount of the substitution for C 6 H 4 (CO) 2 -NOD in methanol-d decreased by ion irradiation. These results suggest that the reaction mechanism in ion irradiation is different from -irradiation. (author)

Knowing You, Knowing Me (KYKM): an interactive game to address positive mother-daughter communication and relationships.

Science.gov (United States)

Katsikitis, Mary; Jones, Christian; Muscat, Melody; Crawford, Kate

2014-01-01

This technical report describes an interactive game environment designed to bring mothers and their adolescent daughters together to discuss three issues that have previously been shown in the literature to be of concern to families, as young girls transition from middle childhood to the adolescent years. The game is called Knowing you, Knowing me or KYKM, and is used to help mothers and daughters discuss the following three topics: positive communication skills, relationship building, and managing risky behaviors in the social environment. As the game remains untested, its limitations and future implications of its utility are discussed.

Knowing You, Knowing Me (KYKM: An interactive game to address positive mother-daughter communication and relationships.

Directory of Open Access Journals (Sweden)

Mary eKatsikitis

2014-07-01

Full Text Available This technical report describes an interactive game environment designed to bring mothers and their adolescent daughters together to discuss three issues that have previously been shown in the literature to be of concern to families, as young girls transition from middle childhood to the adolescent years. The game is called Knowing you, Knowing me or KYKM, and is used to help mothers and daughters discuss the following three topics: positive communication skills, relationship building, and managing risky behaviours in the social environment. As the game remains untested, its limitations and future implications of its utility are discussed.

Sex-ratio biasing towards daughters among lower-ranking co-wives in Rwanda

NARCIS (Netherlands)

Pollet, Thomas V.; Fawcett, Tim W.; Buunk, Abraham P.; Nettle, Daniel

2009-01-01

There is considerable debate as to whether human females bias the sex ratio of their offspring as a function of their own condition. We apply the Trivers-Willard prediction-that mothers in poor condition will overproduce daughters-to a novel measure of condition, namely wife rank within a polygynous

The induction of somatic mutations by high-LET radiations using the drosophila assay system

International Nuclear Information System (INIS)

Yoshikawa, Isao; Takatsuji, Toshihiro

2004-01-01

Two types of somatic mutation in Drosophila melanogaster were examined to evaluate the relative biological effectiveness (RBE) of 252 Cf neutrons and heavy ions (carbon ions and neon ions) accelerated with a synchrotron for inducing mutations as a function of linear energy transfer (LET). One is the loss of heterozygosity for wing-hair mutations and the other the reversion of the mutant white-ivory. The measurements were made using a combined mutation assay system; so that induced mutant wing-hair clones as well as revertant eye-color clones could be detected simultaneously in the same fly. Larvae were irradiated at the age of 3 days post-oviposition. The efficiency of 252 Cf neutrons for inducing wing-hair mosaic spots is very high, RBE=8.5, but that for eye-color mosaic spot is almost equal (RBE=1.2) to that of 137 Cs γ-rays. RBE-LET relationships were obtained for the induction of wing-hair and eye-color mosaic spots. The RBE of carbon and neon ions for producing wing-hair mosaic spots increased with increasing LET values. The RBE for the induction of eye-color mutants did not change with LET. These relationships suggest that more complex types of DNA damage such as non-rejoinable strand breaks or clustered double strand breaks that increase with LET may be responsible for inducing the wing-hair mutation, while simpler forms of molecular damage may induce reversion in the white-ivory allele. (author)

Guanylic nucleotide starvation affects Saccharomyces cerevisiae mother-daughter separation and may be a signal for entry into quiescence

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Sagot Isabelle

2005-05-01

Full Text Available Abstract Background Guanylic nucleotides are both macromolecules constituents and crucial regulators for a variety of cellular processes. Therefore, their intracellular concentration must be strictly controlled. Consistently both yeast and mammalian cells tightly correlate the transcription of genes encoding enzymes critical for guanylic nucleotides biosynthesis with the proliferation state of the cell population. Results To gain insight into the molecular relationships connecting intracellular guanylic nucleotide levels and cellular proliferation, we have studied the consequences of guanylic nucleotide limitation on Saccharomyces cerevisiae cell cycle progression. We first utilized mycophenolic acid, an immunosuppressive drug that specifically inhibits inosine monophosphate dehydrogenase, the enzyme catalyzing the first committed step in de novo GMP biosynthesis. To approach this system physiologically, we next developed yeast mutants for which the intracellular guanylic nucleotide pools can be modulated through changes of growth conditions. In both the pharmacological and genetic approaches, we found that guanylic nucleotide limitation generated a mother-daughter separation defect, characterized by cells with two unseparated daughters. We then showed that this separation defect resulted from cell wall perturbations but not from impaired cytokinesis. Importantly, cells with similar separation defects were found in a wild type untreated yeast population entering quiescence upon nutrient limitation. Conclusion Our results demonstrate that guanylic nucleotide limitation slows budding yeast cell cycle progression, with a severe pause in telophase. At the cellular level, guanylic nucleotide limitation causes the emergence of cells with two unseparated daughters. By fluorescence and electron microscopy, we demonstrate that this phenotype arises from defects in cell wall partition between mother and daughter cells. Because cells with two unseparated

A composite microdose Adaptive Response (AR) and Bystander Effect (BE) model-application to low LET and high LET AR and BE data.

Science.gov (United States)

Leonard, Bobby E

2008-08-01

It has been suggested that Adaptive Response (AR) may reduce risk of adverse health effects due to ionizing radiation. But very low dose Bystander Effects (BE) may impose dominant deleterious human risks. These conflicting behaviors have stimulated controversy regarding the Linear No-Threshold human risk model. A dose and dose rate-dependent microdose model, to examine AR behavior, was developed in prior work. In the prior work a number of in vitro and in vivo dose response data were examined with the model. Recent new data show AR behavior with some evidence of very low dose BE. The purpose of this work is to supplement the microdose model to encompass the Brenner and colleagues BaD (Bystander and Direct Damage) model and apply this composite model to obtain new knowledge regarding AR and BE and illustrate the use of the model to plan radio-biology experiments. The biophysical composite AR and BE Microdose Model quantifies the accumulation of hits (Poisson distributed, microdose specific energy depositions) to cell nucleus volumes. This new composite AR and BE model provides predictions of dose response at very low dose BE levels, higher dose AR levels and even higher dose Direct (linear-quadratic) Damage radiation levels. We find good fits of the model to both BE data from the Columbia University microbeam facility and combined AR and BE data for low Linear Energy Transfer (LET) and high LET data. A Bystander Factor of about 27,000 and an AR protection factor of 0.61 are obtained for the low LET in vivo mouse spleen exposures. A Bystander Factor of 317 and an AR protection factor of 0.53 are obtained for high LET radon alpha particles in human lymphocytes. In both cases the AR is activated at most by one or two radiation induced charged particle traversals through the cell nucleus. The results of the model analysis is consistent with a premise that both Bystander damage and Adaptive Response radioprotection can occur in the same cell type, derived from the same

Influence of chemical inhibitors on cell recovery after exposure to different LET radiation

Energy Technology Data Exchange (ETDEWEB)

Evstratova, Ekaterina S.; Petin, Vladislav G. [Medical Radiological Research Center, Obninsk (Russian Federation); Kim, Jin Kyu; KIm, Jin Hong [Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of)

2016-12-15

Chemical radiosensitizers are often used to increase cell radiosensitivity. It is known that the ability of chemical drugs to increase cell radiosensitivity is related with inhibition of cell recovery from damage induced by ionizing radiation. However, there are little comparative investigations of cell sensitivity modification after exposure to radiation with high linear energy transfer (LET). Therefore, we studied the anticancer drugs cisplatin and endoxan and their impact on the ability of yeast cells to recover after cell exposure to radiations with different LET. The ability of cell recovery from radiation damage was less effective after exposure to high-LET radiation, when cells were irradiated without drug, with the increase in cisplatin concentration resulting in the disappearance of this difference. The increase of cisplatin concentration results in progressive increase in the fraction of irreversible damage independently of radiation quality.

Influence of chemical inhibitors on cell recovery after exposure to different LET radiation

International Nuclear Information System (INIS)

Evstratova, Ekaterina S.; Petin, Vladislav G.; Kim, Jin Kyu; KIm, Jin Hong

2016-01-01

Chemical radiosensitizers are often used to increase cell radiosensitivity. It is known that the ability of chemical drugs to increase cell radiosensitivity is related with inhibition of cell recovery from damage induced by ionizing radiation. However, there are little comparative investigations of cell sensitivity modification after exposure to radiation with high linear energy transfer (LET). Therefore, we studied the anticancer drugs cisplatin and endoxan and their impact on the ability of yeast cells to recover after cell exposure to radiations with different LET. The ability of cell recovery from radiation damage was less effective after exposure to high-LET radiation, when cells were irradiated without drug, with the increase in cisplatin concentration resulting in the disappearance of this difference. The increase of cisplatin concentration results in progressive increase in the fraction of irreversible damage independently of radiation quality.

Effects of diet and exercise on weight-related outcomes for breast cancer survivors and their adult daughters: an analysis of the DAMES trial.

Science.gov (United States)

Tometich, Danielle B; Mosher, Catherine E; Winger, Joseph G; Badr, Hoda J; Snyder, Denise C; Sloane, Richard J; Demark-Wahnefried, Wendy

2017-08-01

Few trials have aimed to promote diet and exercise behaviors in both cancer survivors and their family members and examine their associations with weight-related outcomes. We conducted a secondary analysis to examine associations between change in diet and exercise behaviors and weight-related outcomes for overweight breast cancer survivors and their overweight adult daughters in the Daughters And MothErS Against Breast Cancer (DAMES) randomized trial. The DAMES trial assessed the impact of two iteratively tailored, mailed print diet and exercise interventions against standard brochures over a 12-month period. This analysis examined change in diet and exercise behaviors and weight-related variables from baseline to post-intervention for the 50 breast cancer survivors and their adult daughters randomized to the intervention arms. To reduce the potential for type II error in this pilot, p values diet quality was uniquely related to change in BMI (β = -0.12, p = 0.082), weight (β = -0.12, p = 0.060), and waist circumference (β = -0.38, p = 0.001), whereas change in caloric intake was related to waist circumference (β = 0.21, p = 0.002). For daughters, change in caloric intake was related to change in waist circumference (β = 0.12, p = 0.055). However, change in diet quality was not associated with weight-related outcomes in daughters. Additionally, change in exercise was not associated with weight-related outcomes in mothers or daughters. Findings support mail-based and other tailored interventions for weight loss in this population, with an emphasis on diet quality for breast cancer survivors and caloric intake for their adult daughters.

Preventing substance use among early Asian-American adolescent girls: initial evaluation of a web-based, mother-daughter program.

Science.gov (United States)

Fang, Lin; Schinke, Steven P; Cole, Kristin C A

2010-11-01

This study examined the efficacy and generalizability of a family-oriented, web-based substance use prevention program to young Asian-American adolescent girls. Between September and December 2007, a total of 108 Asian-American girls aged 10-14 years and their mothers were recruited through online advertisements and from community service agencies. Mother-daughter dyads were randomly assigned to an intervention arm or to a test-only control arm. After pretest measurement, intervention-arm dyads completed a 9-session web-based substance use prevention program. Guided by family interaction theory, the program aimed to improve girls' psychological states, strengthen substance use prevention skills, increase mother-daughter interactions, enhance maternal monitoring, and prevent girls' substance use. Study outcomes were assessed using generalized estimating equations. At posttest, relative to control-arm girls, intervention-arm girls showed less depressed mood; reported improved self-efficacy and refusal skills; had higher levels of mother-daughter closeness, mother-daughter communication, and maternal monitoring; and reported more family rules against substance use. Intervention-arm girls also reported fewer instances of alcohol, marijuana, and illicit prescription drug use, and expressed lower intentions to use substances in the future. A family-oriented, web-based substance use prevention program was efficacious in preventing substance use behavior among early Asian-American adolescent girls. Copyright © 2010 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Neoplastic cell transformation by high-LET radiation - Molecular mechanisms

Science.gov (United States)

Yang, Tracy Chui-Hsu; Craise, Laurie M.; Tobias, Cornelius A.; Mei, Man-Tong

1989-01-01

Quantitative data were collected on dose-response curves of cultured mouse-embryo cells (C3H10T1/2) irradiated with heavy ions of various charges and energies. Results suggests that two breaks formed on DNA within 80 A may cause cell transformation and that two DNA breaks formed within 20 A may be lethal. From results of experiments with restriction enzymes which produce DNA damages at specific sites, it was found that DNA double strand breaks are important primary lesions for radiogenic cell transformation and that blunt-ended double-strand breaks can form lethal as well as transformational damages due to misrepair or incomplete repair in the cell. The RBE-LET relationship for high-LET radiation is similar to that for HGPRT locus mutation, chromosomal deletion, and cell transformation, indicating that common lesions may be involved in these radiation effects.

Experimental study of the combined effects of inhalation of radon daughter products and tobacco smoke

International Nuclear Information System (INIS)

Chameaud, J.; Perraud, R.; Chretien, J.; Masse, R.; Lafuma, J.

1979-01-01

For 10 years, over 500 lung cancers have been induced in rats by inhalations of radon daughter products at various concentrations and cumulated doses. Considering several points and the dose-effect relationship especially, such cancers can be compared with human cancers. This type of experiments, fully mastered, has made it possible to undertake under good conditions the study of the co-carcinogenic effect of various inhaled pollutants such as tobacco smoke. In a first experiment, 100 rats were exposed to a 4000WLM cumulated dose of radon daughter products, knowing that this level induces some 30% of lung cancers. 50 animals were then administered tobacco smoke by inhalation in a fume box during 5 months (350 h.) In the group inhaling radon only, 17 cancers appeared; in the radon -tobacco group 32 cancers bigger and more invasive were observed. Under the same conditions, tobacco smoke was inhaled by rats previously exposed to lower doses of radon daughter products (2 groups of 30 rats, 500 and 100 WLM respectively). Again, the number of cancers observed was higher that the number of cancers expected if the rats had inhaled radon only. This co-carcinogenic and potentiating action of tobacco was clearly demonstrated. Further experiments are considered in order to determine the processes involved

IGF-1/IGF-1R/hsa-let-7c axis regulates the committed differentiation of stem cells from apical papilla

Science.gov (United States)

Ma, Shu; Liu, Genxia; Jin, Lin; Pang, Xiyao; Wang, Yanqiu; Wang, Zilu; Yu, Yan; Yu, Jinhua

2016-01-01

Insulin-like growth factor-1 (IGF-1) and its receptor IGF-1R play a paramount role in tooth/bone formation while hsa-let-7c actively participates in the osteogenic differentiation of mesenchymal stem cells. However, the interaction between IGF-1/IGF-1R and hsa-let-7c on the committed differentiation of stem cells from apical papilla (SCAPs) remains unclear. In this study, human SCAPs were isolated and treated with IGF-1 and hsa-let-7c over/low-expression viruses. The odonto/osteogenic differentiation of these stem cells and the involvement of mitogen-activated protein kinase (MAPK) pathway were subsequently investigated. Alizarin red staining showed that hsa-let-7c low-expression can significantly promote the mineralization of IGF-1 treated SCAPs, while hsa-let-7c over-expression can decrease the calcium deposition of IGF-1 treated SCAPs. Western blot assay and real-time reverse transcription polymerase chain reaction further demonstrated that the expression of odonto/osteogenic markers (ALP, RUNX2/RUNX2, OSX/OSX, OCN/OCN, COL-I/COL-I, DSPP/DSP, and DMP-1/DMP-1) in IGF-1 treated SCAPs were significantly upregulated in Let-7c-low group. On the contrary, hsa-let-7c over-expression could downregulate the expression of these odonto/osteogenic markers. Moreover, western blot assay showed that the JNK and p38 MAPK signaling pathways were activated in Let-7c-low SCAPs but inhibited in Let-7c-over SCAPs. Together, the IGF-1/IGF-1R/hsa-let-7c axis can control the odonto/osteogenic differentiation of IGF-1-treated SCAPs via the regulation of JNK and p38 MAPK signaling pathways. PMID:27833148

Protective Effects of Let-7b on the Expression of Occludin by Targeting P38 MAPK in Preventing Intestinal Barrier Dysfunction

Directory of Open Access Journals (Sweden)

Zhihua Liu

2018-01-01

Full Text Available Background/Aims: Let-7b was dramatically reduced after a dicer knockout of mice with intestinal barrier function injuries. This paper aims to investigate the molecular mechanism of let-7b by targeting p38 MAPK in preventing intestinal barrier dysfunction. Methods: A total of 186 patients were enrolled, with 93 in the control group and 93 in the PRO group. Only 158 patients completed the entire study, whereas the others either did not meet the inclusion criteria or refused to participate. To further verify the role of let-7b, intestinal epithelial conditional knockout (IKO mice of mmu-let-7b model were established. Serum let-7b, zonulin, IL-6, and TNF-α concentrations were measured by ELISA or quantitative RT-PCR. Permeability assay was done by ussing chamber. The apoptotic cells were identified using an In Situ Cell Death Detection Kit. Protein was detected by western blot. Results: Probiotics can lower infection-related complications, as well as increase the serum and tissue let-7b levels. P38 MAPK was identified as the target of let-7b, as verified by NCM460 cells. P38 MAPK expression was increased, whereas tight-junction (TJ proteins were significantly decreased in let-7b IKO mice (both P<0.05. Negative regulation of p38 MAPK molecular signaling pathways was involved in the protective effects of let-7b on intestinal barrier function. Conclusion: Let-7b was identified as a novel diagnosis biomarker or a potential treatment target for preventing intestinal barrier dysfunction.

Protective Effects of Let-7b on the Expression of Occludin by Targeting P38 MAPK in Preventing Intestinal Barrier Dysfunction.

Science.gov (United States)

Liu, Zhihua; Tian, Yinghai; Jiang, Yanqiong; Chen, Shihua; Liu, Ting; Moyer, Mary Pat; Qin, Huanlong; Zhou, Xinke

2018-01-01

Let-7b was dramatically reduced after a dicer knockout of mice with intestinal barrier function injuries. This paper aims to investigate the molecular mechanism of let-7b by targeting p38 MAPK in preventing intestinal barrier dysfunction. A total of 186 patients were enrolled, with 93 in the control group and 93 in the PRO group. Only 158 patients completed the entire study, whereas the others either did not meet the inclusion criteria or refused to participate. To further verify the role of let-7b, intestinal epithelial conditional knockout (IKO) mice of mmu-let-7b model were established. Serum let-7b, zonulin, IL-6, and TNF-α concentrations were measured by ELISA or quantitative RT-PCR. Permeability assay was done by ussing chamber. The apoptotic cells were identified using an In Situ Cell Death Detection Kit. Protein was detected by western blot. Probiotics can lower infection-related complications, as well as increase the serum and tissue let-7b levels. P38 MAPK was identified as the target of let-7b, as verified by NCM460 cells. P38 MAPK expression was increased, whereas tight-junction (TJ) proteins were significantly decreased in let-7b IKO mice (both P<0.05). Negative regulation of p38 MAPK molecular signaling pathways was involved in the protective effects of let-7b on intestinal barrier function. Let-7b was identified as a novel diagnosis biomarker or a potential treatment target for preventing intestinal barrier dysfunction. © 2018 The Author(s). Published by S. Karger AG, Basel.

The Spectacle of Terrorism: Exploring the Notions of ‘Blind Acting Out’ and ‘Phatic Communication’

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Wilson Mwenda Kailemia

2016-05-01

Full Text Available The present paper proposes the parallels between ‘staged’ incidences of terrorism and ‘spectacular public disorder’ as a supplementary reading of terrorism. I claim that, while the spectacular in both is not 'par se'- or even an exhaustive- account of how terrorism functions, there is an aspect of what the French philosopher Alain Badiou has referred to as 'Passage a l’acte' (‘blind acting out’- coined apropos of the 2006 Paris riots- which should exercise our attention. The methodology of 'passage a l’acte' is to draw maximum attention to an issue by letting the extended post-attack coverage ‘do the talking’. The article also shows how ‘phatic communication’, a term coined by Malinowski, is an important component of 'passage a l’acte'

Inactive and mutagenic effects induced by carbon beams of different LET values in a red yeast strain

International Nuclear Information System (INIS)

Wang Jufang; Lu Dong; Wu Xin; Sun Haining; Ma Shuang; Li Renmin; Li Wenjian

2010-01-01

To evaluate biological action of microorganism exposed to charged particles during the long distance space exploration, induction of inactivation and mutation in a red yeast strain Rhodotorula glutinis AY 91015 by carbon beams of different LET values (14.9-120.0 keV μm -1 ) was investigated. It was found that survival curves were exponential, and mutation curves were linear for all LET values. The dependence of inactivation cross section on LET approached saturation near 120.0 keV μm -1 . The mutation cross section saturated when LET was higher than 58.2 keV μm -1 . Meanwhile, the highest RBE i for inactivation located at 120.0 keV μm -1 and the highest RBE m for mutation was at 58.2 keV μm -1 . The experiments imply that the most efficient mutagenic part of the depth dose profile of carbon ion is at the plateau region with intermediate LET value in which energy deposited is high enough to induce mutagenic lesions but too low to induce over kill effect in the yeast cells.

Inactive and mutagenic effects induced by carbon beams of different LET values in a red yeast strain

Science.gov (United States)

Wang, Jufang; Lu, Dong; Wu, Xin; Sun, Haining; Ma, Shuang; Li, Renmin; Li, Wenjian

2010-09-01

To evaluate biological action of microorganism exposed to charged particles during the long distance space exploration, induction of inactivation and mutation in a red yeast strain Rhodotorula glutinis AY 91015 by carbon beams of different LET values (14.9-120.0 keV μm -1) was investigated. It was found that survival curves were exponential, and mutation curves were linear for all LET values. The dependence of inactivation cross section on LET approached saturation near 120.0 keV μm -1. The mutation cross section saturated when LET was higher than 58.2 keV μm -1. Meanwhile, the highest RBE i for inactivation located at 120.0 keV μm -1 and the highest RBE m for mutation was at 58.2 keV μm -1. The experiments imply that the most efficient mutagenic part of the depth dose profile of carbon ion is at the plateau region with intermediate LET value in which energy deposited is high enough to induce mutagenic lesions but too low to induce over kill effect in the yeast cells.

MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis.

Science.gov (United States)

Zhao, Chunnian; Sun, GuoQiang; Ye, Peng; Li, Shengxiu; Shi, Yanhong

2013-01-01

MicroRNAs have important functions in the nervous system through post-transcriptional regulation of neurogenesis genes. Here we show that microRNA let-7d, which has been implicated in cocaine addiction and other neurological disorders, targets the neural stem cell regulator TLX. Overexpression of let-7d in vivo reduced neural stem cell proliferation and promoted premature neuronal differentiation and migration, a phenotype similar to those induced by TLX knockdown or overexpression of its negatively-regulated target, microRNA-9. We found a let-7d binding sequence in the tlx 3' UTR and demonstrated that let-7d reduced TLX expression levels in neural stem cells, which in turn, up-regulated miR-9 expression. Moreover, co-expression of let-7d and TLX lacking its 3' UTR in vivo restored neural stem cell proliferation and reversed the premature neuronal differentiation and migration. Therefore, manipulating let-7d and its downstream targets could be a novel strategy to unravel neurogenic signaling pathways and identify potential interventions for relevant neurological disorders.

Linear energy transfer (LET) effects in the radiation-induced inactivation of papain

International Nuclear Information System (INIS)