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Sample records for lessons mao osama

  1. Old Book, New Lessons: Mao, Osama, and the Global Qutbist Insurgency

    National Research Council Canada - National Science Library

    Rueschhoff, Jan L

    2008-01-01

    .... Despite these theorists' claims, a long trail of evidence points to a deliberate attempt by Al Qaeda's leadership to model their actions after Mao Tse-tung, Che Guevara, and other classical insurgent...

  2. Osama bin Ladeni uus imidzh / Urmas Kiil

    Index Scriptorium Estoniae

    Kiil, Urmas

    2007-01-01

    Pärast kolm aastat kestnud pausi ilmus terroriorganisatsiooni al-Qaeda liider Osama bin Laden kahel korral taas maailma avalikkuse ette. Enamik asjatundjad on seisukohal, et maailma esiterroristi videopöördumised olid autentsed ja tõenäoliselt olid need salvestatud juulis või augustis

  3. Miks Osama bin Ladenit pole siiani tabatud? / Peeter Ernits

    Index Scriptorium Estoniae

    Ernits, Peeter, 1953-

    2008-01-01

    Afganistanis viibinud ajakirjaniku eesmärgiks oli teada saada, miks vaatamata kõigile püüdlustele vägivald Afganistanis siiski ei vähene ning kus varjab ennast Al Qaeda liider Osama bin Laden. Lisad: Osama bin Laden; 11. september 2001

  4. Pakistan andis Osama bin Ladeni jahtimisel alla / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2004-01-01

    Pakistani president Pervez Musharrafi sõnul on Osama bin Ladeni otsingud Lõuna-Waziristanis tulemusteta. Edaspidi keskendutakse otsingutel Põhja-Waziristani, oletatakse, et bin Laden võib olla ka Tora Bora koobastikus. Lisa: USA hambutu luureteenistus

  5. Osama bin Ladeni tapmine toonuks tuumapõrgu / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2011-01-01

    Wikileaksi kaudu on avalikustatud märkmeid Guantánamo vangide ülekuulamistest. Ühe al-Qaida komandöri väitel on terroristidel kuhugi Euroopasse peidetud tuumapomm, mis oleks pandud plahvatama, kui Osama bin Laden oleks vangistatud või tapetud. Selgub, et Guantanamos oli umbes 150 kinnipeetut täiesti süütud

  6. Recension: Mao - The Unknown Story

    DEFF Research Database (Denmark)

    Clausen, Søren

    2005-01-01

    Anmeldelse - kritisk! - til Sveriges førende Kinatidsskrift af Jung Chang & Jon Halliday's sensationelle "Mao - the Unknown Story".......Anmeldelse - kritisk! - til Sveriges førende Kinatidsskrift af Jung Chang & Jon Halliday's sensationelle "Mao - the Unknown Story"....

  7. Vicarious revenge and the death of Osama bin Laden.

    Science.gov (United States)

    Gollwitzer, Mario; Skitka, Linda J; Wisneski, Daniel; Sjöström, Arne; Liberman, Peter; Nazir, Syed Javed; Bushman, Brad J

    2014-05-01

    Three hypotheses were derived from research on vicarious revenge and tested in the context of the assassination of Osama bin Laden in 2011. In line with the notion that revenge aims at delivering a message (the "message hypothesis"), Study 1 shows that Americans' vengeful desires in the aftermath of 9/11 predicted a sense of justice achieved after bin Laden's death, and that this effect was mediated by perceptions that his assassination sent a message to the perpetrators to not "mess" with the United States. In line with the "blood lust hypothesis," his assassination also sparked a desire to take further revenge and to continue the "war on terror." Finally, in line with the "intent hypothesis," Study 2 shows that Americans (but not Pakistanis or Germans) considered the fact that bin Laden was killed intentionally more satisfactory than the possibility of bin Laden being killed accidentally (e.g., in an airplane crash).

  8. Osama bin Laden - elus või siiski ammu surnud? / Aadu Hiietamm

    Index Scriptorium Estoniae

    Hiietamm, Aadu, 1954-

    2009-01-01

    USA on terrorivõrgustiku al Qaeda juhti Osama bin Ladenit jahitud juba kaheksa aastat, kuid tulemusteta. Vandenõuteoreetikute arvates on ta ammu surnud, kuid USA Luure Keskagentuuri juhi arvates varjab ta end Pakistanis

  9. The Peril of Hasty Triumphalism and Osama bin Laden’s Death

    Directory of Open Access Journals (Sweden)

    Eugenio Lilli

    2011-05-01

    Full Text Available On May 1, 2011 the headlines of a large number of newspapers and TV channels around the world were saying “justice has been done”. Those were the words used by the US President Barack Obama to announce to the world the killing of Osama bin Laden, the number one terrorist on the US most-wanted list.

  10. Mao-Gilles Stabilization Algorithm

    OpenAIRE

    Jérôme Gilles

    2013-01-01

    Originally, the Mao-Gilles stabilization algorithm was designed to compensate the non-rigid deformations due to atmospheric turbulence. Given a sequence of frames affected by atmospheric turbulence, the algorithm uses a variational model combining optical flow and regularization to characterize the static observed scene. The optimization problem is solved by Bregman Iteration and the operator splitting method. The algorithm is simple, efficient, and can be easily generalized for different sce...

  11. Mao-Gilles Stabilization Algorithm

    Directory of Open Access Journals (Sweden)

    Jérôme Gilles

    2013-07-01

    Full Text Available Originally, the Mao-Gilles stabilization algorithm was designed to compensate the non-rigid deformations due to atmospheric turbulence. Given a sequence of frames affected by atmospheric turbulence, the algorithm uses a variational model combining optical flow and regularization to characterize the static observed scene. The optimization problem is solved by Bregman Iteration and the operator splitting method. The algorithm is simple, efficient, and can be easily generalized for different scenarios involving non-rigid deformations.

  12. Afghanistan, the Taliban, and Osama bin Laden: The Background to September 11

    Science.gov (United States)

    Social Education, 2011

    2011-01-01

    On May 1, 2011, a group of U.S. soldiers boarded helicopters at a base in Afghanistan, hoping to find a man named Osama bin Laden. Bin Laden, the leader of the al Qaeda terrorist network, was responsible for a number of terrorist attacks around the world, including those of September 11, 2001, that killed nearly 3,000 people in the United States.…

  13. Stratfori analüütik Sean Noonan: taktikaliselt suri Osama juba ammu / Sean Noonan ; intervjueerinud Holger Roonemaa

    Index Scriptorium Estoniae

    Noonan, Sean

    2011-01-01

    Stratfori analüütiku hinnangul nähakse araabia maades Osama bin Ladeni surmas tõenäoliselt märtrisurma. Lähiajal võib toimuda väga algelisi kättemaksuüritusi, keskplaanis tõenäoliselt toimub suurem radikaliseerumine. Bin Ladeni tapmine annab USA presidendile rohkem motivatsiooni õigustada Afganistanist lahkumist

  14. Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology

    Directory of Open Access Journals (Sweden)

    John Paul Maurice Finberg

    2016-10-01

    Full Text Available Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and neurological disorders respectively. Elucidation of the molecular structure of the active sites of the enzymes has enabled a precise determination of the way in which substrates and inhibitor molecules are metabolized, or inhibit metabolism of substrates, respectively. Despite the knowledge of the strong antidepressant efficacy of irreversible MAO inhibitors, their clinical use has been limited by their side effect of potentiation of the cardiovascular effects of dietary amines (cheese effect. A number of reversible MAO-A inhibitors which are devoid of cheese effect have been described in the literature, but only one, moclobemide, is currently in clinical use. The irreversible inhibitors of MAO-B, selegiline and rasagiline, are used clinically in treatment of Parkinson’s disease, and a recently introduced reversible MAO-B inhibitor, safinamide, has also been found efficacious. Modification of the pharmacokinetic characteristics of selegiline by transdermal administration has led to the development of a new drug form for treatment of depression. The clinical potential of MAO inhibitors together with detailed knowledge of the enzyme’s binding site structure should lead to future developments with these drugs.

  15. Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology.

    Science.gov (United States)

    Finberg, John P M; Rabey, Jose M

    2016-01-01

    Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and neurological disorders respectively. Elucidation of the molecular structure of the active sites of the enzymes has enabled a precise determination of the way in which substrates and inhibitor molecules are metabolized, or inhibit metabolism of substrates, respectively. Despite the knowledge of the strong antidepressant efficacy of irreversible MAO inhibitors, their clinical use has been limited by their side effect of potentiation of the cardiovascular effects of dietary amines ("cheese effect"). A number of reversible MAO-A inhibitors which are devoid of cheese effect have been described in the literature, but only one, moclobemide, is currently in clinical use. The irreversible inhibitors of MAO-B, selegiline and rasagiline, are used clinically in treatment of Parkinson's disease, and a recently introduced reversible MAO-B inhibitor, safinamide, has also been found efficacious. Modification of the pharmacokinetic characteristics of selegiline by transdermal administration has led to the development of a new drug form for treatment of depression. The clinical potential of MAO inhibitors together with detailed knowledge of the enzyme's binding site structure should lead to future developments with these drugs.

  16. MAO-A promoter polymorphism and idiopathic pulmonary arterial ...

    Indian Academy of Sciences (India)

    Introduction. Monoamine oxidases (MAO) are mitochondrial enzymes ... liver and later in lungs by the enzyme MAO-A, via ox- ... Diagnosis was based on WHO criteria .... treatment of pulmonary arterial hypertension of the European so-.

  17. Norrie disease and MAO genes: nearest neighbors.

    Science.gov (United States)

    Chen, Z Y; Denney, R M; Breakefield, X O

    1995-01-01

    The Norrie disease and MAO genes are tandemly arranged in the p11.4-p11.3 region of the human X chromosome in the order tel-MAOA-MAOB-NDP-cent. This relationship is conserved in the mouse in the order tel-MAOB-MAOA-NDP-cent. The MAO genes appear to have arisen by tandem duplication of an ancestral MAO gene, but their positional relationship to NDP appears to be random. Distinctive X-linked syndromes have been described for mutations in the MAOA and NDP genes, and in addition, individuals have been identified with contiguous gene syndromes due to chromosomal deletions which encompass two or three of these genes. Loss of function of the NDP gene causes a syndrome of congenital blindness and progressive hearing loss, sometimes accompanied by signs of CNS dysfunction, including variable mental retardation and psychiatric symptoms. Other mutations in the NDP gene have been found to underlie another X-linked eye disease, exudative vitreo-retinopathy. An MAOA deficiency state has been described in one family to date, with features of altered amine and amine metabolite levels, low normal intelligence, apparent difficulty in impulse control and cardiovascular difficulty in affected males. A contiguous gene syndrome in which all three genes are lacking, as well as other as yet unidentified flanking genes, results in severe mental retardation, small stature, seizures and congenital blindness, as well as altered amine and amine metabolites. Issues that remain to be resolved are the function of the NDP gene product, the frequency and phenotype of the MAOA deficiency state, and the possible occurrence and phenotype of an MAOB deficiency state.

  18. The post-Mao gazes: Chinese backpackers in Macau

    NARCIS (Netherlands)

    Ong, C.E.; Cros, du H.

    2012-01-01

    This paper offers insights into backpacker tourism from the People’s Republic of China. Chinese backpackers are a distinctively post-Mao reform generation growing up at a time when China shifts from Mao Zedong’s socialist policies to Deng Xiaoping’s policy explorations with capitalism. Through

  19. Monoamine Oxidase Inhibitory Constituents of Propolis: Kinetics and Mechanism of Inhibition of Recombinant Human MAO-A and MAO-B

    Directory of Open Access Journals (Sweden)

    Narayan D. Chaurasiya

    2014-11-01

    Full Text Available Propolis is the resinous material that bees gather from leaf buds, flowers and vegetables. Propolis extracts contain constituents with a broad spectra of pharmacological properties and are important ingredients of popular dietary supplements. Propolis extracts were evaluated in vitro for inhibition of recombinant human monoamine oxidase (MAO-A and MAO-B. The dichloromethane extract of propolis showed potent inhibition of human MAO-A and MAO-B. Further fractionation identified the most active fractions as rich in flavonoids. Galangin and apigenin were identified as the principal MAO-inhibitory constituents. Inhibition of MAO-A by galangin was about 36 times more selective than MAO-B, while apigenin selectivity for MAO-A vs. MAO-B was about 1.7 fold. Apigenin inhibited MAO-B significantly more potently than galangin. Galangin and apigenin were further evaluated for kinetic characteristics and the mechanism for the enzymes’ inhibition. Binding of galangin and apigenin with MAO-A and -B was not time-dependent and was reversible, as suggested by enzyme-inhibitor binding and dissociation-dialysis assay. The inhibition kinetics studies suggested that galangin and apigenin inhibited MAO-A and -B by a competitive mechanism. Presence of prominent MAO inhibitory constituents in propolis products suggests their potential for eliciting pharmacological effects that might be useful in depression or other neurological disorders. The results may also have important implications in drug-dietary supplement interactions.

  20. Monoamine oxidase A (MAO A) inhibitors decrease glioma progression

    Science.gov (United States)

    Vaikari, Vijaya Pooja; Kota, Rajesh; Chen, Kevin; Yeh, Tzu-Shao; Jhaveri, Niyati; Groshen, Susan L.; Olenyuk, Bogdan Z.; Chen, Thomas C.; Hofman, Florence M.; Shih, Jean C.

    2016-01-01

    Glioblastoma (GBM) is an aggressive brain tumor which is currently treated with temozolomide (TMZ). Tumors usually become resistant to TMZ and recur; no effective therapy is then available. Monoamine Oxidase A (MAO A) oxidizes monoamine neurotransmitters resulting in reactive oxygen species which cause cancer. This study shows that MAO A expression is increased in human glioma tissues and cell lines. MAO A inhibitors, clorgyline or the near-infrared-dye MHI-148 conjugated to clorgyline (NMI), were cytotoxic for glioma and decreased invasion in vitro. Using the intracranial TMZ-resistant glioma model, clorgyline or NMI alone or in combination with low-dose TMZ reduced tumor growth and increased animal survival. NMI was localized specifically to the tumor. Immunocytochemistry studies showed that the MAO A inhibitor reduced proliferation, microvessel density and invasion, and increased macrophage infiltration. In conclusion, we have identified MAO A inhibitors as potential novel stand-alone drugs or as combination therapy with low dose TMZ for drug-resistant gliomas. NMI can also be used as a non-invasive imaging tool. Thus has a dual function for both therapy and diagnosis. PMID:26871599

  1. Inhibition of MAO by fractions and constituents of hypericum extract.

    Science.gov (United States)

    Bladt, S; Wagner, H

    1994-10-01

    The inhibition of monoamine oxidase (MAO) by six fractions from hypericum extract and three characteristic constituents (as pure substances) were analyzed in vitro and ex vivo to study the antidepressive mechanism of action. Rat brain homogenates were used as the in vitro model, while the ex vivo analysis was performed after intraperitoneal application of the test substances to albino rats. Massive inhibition of MAO-A could be shown with the total extract and all fractions only at the concentration of 10(-3) mol/L. At 10(-4) mol/L, one fraction rich in flavonoides showed an inhibition of 39%, and all other fractions demonstrated less than 25% inhibition. Using pure hypericin as well as in all ex vivo experiments, no relevant inhibiting effects could be shown. From the results it can be concluded that the clinically proven antidepressive effect of hypericum extract cannot be explained in terms of MAO inhibition.

  2. New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.

    Science.gov (United States)

    La Regina, Giuseppe; Silvestri, Romano; Artico, Marino; Lavecchia, Antonio; Novellino, Ettore; Befani, Olivia; Turini, Paola; Agostinelli, Enzo

    2007-03-08

    A series of new pyrrole derivatives have been synthesized and evaluated for their monoamine oxidase (MAO) A and B inhibitory activity and selectivity. N-Methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine (7) and N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine (18) were the most selective MAO-B (7, SI = 0.0057) and MAO-A (18, SI = 12500) inhibitors, respectively. Docking and molecular dynamics simulations gave structural insights into the MAO-A and MAO-B selectivity. Compound 18 forms an H-bond with Gln215 through its protonated amino group into the MAO-A binding site. This H-bond is absent in the 7/MAO-A complex. In contrast, compound 7 places its phenyl ring into an aromatic cage of the MAO-B binding pocket, where it forms charge-transfer interactions. The slightly different binding pose of 18 into the MAO-B active site seems to be forced by a bulkier Tyr residue, which replaces a smaller Ile residue present in MAO-A.

  3. Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: focus on modulation of CNS monoamine neurotransmitter release.

    Science.gov (United States)

    Finberg, John P M

    2014-08-01

    Inhibitors of monoamine oxidase (MAO) were initially used in medicine following the discovery of their antidepressant action. Subsequently their ability to potentiate the effects of an indirectly-acting sympathomimetic amine such as tyramine was discovered, leading to their limitation in clinical use, except for cases of treatment-resistant depression. More recently, the understanding that: a) potentiation of indirectly-acting sympathomimetic amines is caused by inhibitors of MAO-A but not by inhibitors of MAO-B, and b) that reversible inhibitors of MAO-A cause minimal tyramine potentiation, has led to their re-introduction to clinical use for treatment of depression (reversible MAO-A inhibitors and new dose form MAO-B inhibitor) and treatment of Parkinson's disease (MAO-B inhibitors). The profound neuroprotective properties of propargyl-based inhibitors of MAO-B in preclinical experiments have drawn attention to the possibility of employing these drugs for their neuroprotective effect in neurodegenerative diseases, and have raised the question of the involvement of the MAO-mediated reaction as a source of reactive free radicals. Despite the long-standing history of MAO inhibitors in medicine, the way in which they affect neuronal release of monoamine neurotransmitters is still poorly understood. In recent years, the detailed chemical structure of MAO-B and MAO-A has become available, providing new possibilities for synthesis of mechanism-based inhibitors. This review describes the latest advances in understanding the way in which MAO inhibitors affect the release of the monoamine neurotransmitters dopamine, noradrenaline and serotonin (5-HT) in the CNS, with an accent on the importance of these effects for the clinical actions of the drugs. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. Rhetoric, Literacy, and Social Change in Post-Mao China

    Science.gov (United States)

    Wexler, Steven

    2009-01-01

    State, citizen, and corporate readings of a multifarious "Chineseness" fundamentally shape the space where East and West clash in post-Mao China. This dialectic represents a citizen's working-through a crisis of agency and a nation's negotiation of its role within a global economy. Given that China's subaltern literacies operate within…

  5. Mao & Püha Eliisabet / Jüri Kuuskemaa

    Index Scriptorium Estoniae

    Kuuskemaa, Jüri, 1942-

    2000-01-01

    Kadrioru lossis Väliskunstimuuseumi ekspositsioonis olevast antikvaar August Käbi pärandist pärit maalist. Kunstiteadlase Mai Levini arvates võib maali autoriks olla Rooma kunstnik Tommaso Salini, hüüdnimega Mao. Maali süzee: "Püha Eliisabeti kuulutus". 1 ill

  6. Biphasic and region-specific MAO-B response to aging in normal human brain.

    Science.gov (United States)

    Saura, J; Andrés, N; Andrade, C; Ojuel, J; Eriksson, K; Mahy, N

    1997-01-01

    Variations of monoamine oxidases (MAO) A and B were studied during aging in 27 human subjects (age range 17-93 years) in 18 brain structures of temporal cortex, frontal gyrus, hippocampal formation, striatum, cerebellum, and brainstem. [3H]Ro41-1049 and [3H]lazabemide were used as selective radioligands to image and quantify MAO-A and MAO-B respectively by enzyme autoradiography. Postmortem delay or time of tissue storage did not affect MAO-A or MAO-B levels. There was, moreover, no evidence of sexual dimorphism. A marked age-related increase in MAO-B was observed in most structures. This increase started at the age of 50-60 years. Before this age, MAO-B levels were constant in all structures studied. MAO-B-rich senile plaques were observed in some cortical areas but they did not significantly influence the age-related MAO-B increase. Surprisingly, no age-related MAO-B changes were observed in the substantia nigra. In contrast to MAO-B, no clear age-related changes in MAO-A were observed, indicating an independent regulation of the two isoenzymes, also suggested by the cross-correlation analysis of these data.

  7. First results of MAO NASU SS bodies photographic archive digitizing

    Science.gov (United States)

    Pakuliak, L.; Andruk, V.; Shatokhina, S.; Golovnya, V.; Yizhakevych, O.; Kulyk, I.

    2013-05-01

    MAO NASU glass archive encloses about 1800 photographic plates with planets and their satellites (including near 80 images of Uranus, Pluto and Neptune), about 1700 plates with minor planets and about 900 plates with comets. Plates were made during 1949-1999 using 11 telescopes of different focus, mostly the Double Wide-angle Astrograph (F/D=2000/400) and the Double Long-focus Astrograph (F/D=5500/400) of MAO NASU. Observational sites are Kyiv, Lviv (Ukraine), Biurakan (Armenia), Abastumani (Georgia), Mt. Maidanak (Uzbekistan), Quito (Equador). Tables contain data about the most significant numbers of plates sub-divided by years and objects. The database with metadata of plates (DBGPA) is available on the computer cluster of MAO (http://gua.db.ukr-vo.org) via open access. The database accumulates archives of four Ukrainian observatories, involving the UkrVO national project. Together with the archive managing system, the database serves as a test area for JDA - Joint Digital Archive - the core of the UkrVO.

  8. The Storage Stability of Anthocyanins in Mao (Antidesma thwaitesianum Müll. Arg. Juice and Concentrate

    Directory of Open Access Journals (Sweden)

    Prommakool Arunya

    2016-01-01

    Full Text Available Mao or Makmao (Antidesma thwaitesianum Müll. Arg. is a wild plant found in the northeast of Thailand. Mao is one of fruits which are source of anthocyanins. Mao fruits are used for juice and concentrate which are consumed for healthy drinks. Determination of the kinetic parameters is essential to predict the quality changes and stability of anthocyanins in Mao juice and concentrate that occur during storage. The purpose of this research was to study the degradation of anthocyanins in Mao juice and concentrate during storage at 5, 30 and 37°C for 15 days. The storage stability of Mao anthocyanins was studied in 15°Brix juice and 45°Brix concentrate. The degradation kinetic (k, half-life (t1/2, activation energy (Ea and Q10 values for Mao anthocyanins degradation were determined. The results indicated that analysis of kinetic data for the degradation of anthocyanins followed a first-order reaction. An increase storage temperature from 5 to 30 and 37°C increased k value of anthocyanins in Mao juice and concentrate. Increasing storage temperature decreased t1/2 value of anthocyanins in both concentrations. At 5, 30 and 37°C, the t1/2 of anthocyanins decreased from 35 to 13 and 5 days for Mao juice and 32 to 25 and 21 days for Mao concentrate. The Ea value of the anthocyanins degradation in Mao juice and concentrate were 38.03 and 8.42 kJ/mol, respectively. Q10 values of both Mao juice and concentrate at 30-37°C were higher than those were storaged at 5-30°C. Thus higher stability of anthocyanins was achieved by using concentration and storage at lower temperature.

  9. Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO.

    Science.gov (United States)

    Coelho Cerqueira, Eduardo; Netz, Paulo Augusto; Diniz, Cristiane; Petry do Canto, Vanessa; Follmer, Cristian

    2011-12-15

    Monoamine oxidase (MAO) catalyzes the oxidative deamination of biogenic and exogenous amines and its inhibitors have therapeutic value for several conditions including affective disorders, stroke, neurodegenerative diseases and aging. The discovery of 2,3,6-trimethyl-1,4-naphthoquinone (TMN) as a nonselective and reversible inhibitor of MAO, has suggested 1,4-naphthoquinone (1,4-NQ) as a potential scaffold for designing new MAO inhibitors. Combining molecular modeling tools and biochemical assays we evaluate the kinetic and molecular details of the inhibition of human MAO by 1,4-NQ, comparing it with TMN and menadione. Menadione (2-methyl-1,4-naphthoquinone) is a multitarget drug that acts as a precursor of vitamin K and an inducer of mitochondrial permeability transition. Herein we show that MAO-B was inhibited competitively by 1,4-NQ (K(i)=1.4 μM) whereas MAO-A was inhibited by non-competitive mechanism (K(i)=7.7 μM). Contrasting with TMN and 1,4-NQ, menadione exhibited a 60-fold selectivity for MAO-B (K(i)=0.4 μM) in comparison with MAO-A (K(i)=26 μM), which makes it as selective as rasagiline. Fluorescence and molecular modeling data indicated that these inhibitors interact with the flavin moiety at the active site of the enzyme. Additionally, docking studies suggest the phenyl side groups of Tyr407 and Tyr444 (for MAO-A) or Tyr398 and Tyr435 (for MAO-B) play an important role in the interaction of the enzyme with 1,4-NQ scaffold through forces of dispersion as verified for menadione, TMN and 1,4-NQ. Taken together, our findings reveal the molecular details of MAO inhibition by 1,4-NQ scaffold and show for the first time that menadione acts as a competitive and reversible inhibitor of human MAO. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Age-related changes of MAO-A and -B distribution in human and mouse brain.

    Science.gov (United States)

    Mahy, N; Andrés, N; Andrade, C; Saura, J

    2000-01-01

    Age-related changes of MAO-A and -B were studied in human and BL/C57 mouse brain areas (substantia nigra, putamen and cerebellum). [3H]Ro41-1049 and [3H]lazabemide were used as selective radioligands to image and quantify MAO-A and MAO-B respectively by enzyme autoradiography. MAO-A binding was higher in mouse, whereas MAO-B binding was higher in human. With aging, mouse MAO-A was significantly reduced between 4 and 8 weeks and remained unchanged until 19 months followed by a slight increase between 19 and 25 months. In contrast, no clear variation was observed in humans between the age of 17-93 years. In most of the structures studied a clear age-related increase in MAO-B was observed beginning in mouse brain at 4 weeks, whereas in human tissue this increase started at the age of 50-60 years. These results show marked differences in the levels and variations of mouse and human MAO-A and -B associated with aging and should be taken into account when extrapolating experimental data from mouse to human.

  11. On Mao Tse-tung: A Bibliographic Guide. East Asia Series, Occasional Paper No. 2.

    Science.gov (United States)

    Shu, Austin C. W.

    This bibliography is a selected reference source on the life, politics, philosophy, and works of Mao Tse-tung. It contains 800 documents in Chinese, Japanese, and Western languages that were selected from monographs and journal articles. Most of the entries pertain to Mao's role after 1949 when he emerged as the new leader in Mainland China. The…

  12. MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

    DEFF Research Database (Denmark)

    Kaya, Duygu; Jäger, Anna; Yalçin, Funda N

    2014-01-01

    Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H20 extracts prepared from the methanolic extracts of the title...

  13. Influence of MAO Treatment on the Galvanic Corrosion Between Aluminum Alloy and 316L Steel

    Science.gov (United States)

    Yang, Yuanhang; Gu, Yanhong; Zhang, Lei; Jiao, Xiangdong; Che, Juntie

    2017-12-01

    To slow down the galvanic corrosion of aluminum alloy and 316L stainless steel in subsea water, a micro-arc oxidation (MAO) coating was prepared on the surface of the Al alloy, and no treatment was performed on the surface of the 316L. The surface morphology of MAO-coated Al alloy was evaluated using a scanning electron microscope (SEM) before and after corrosion. A micro-hardness tester was used to measure the micro-hardness. Corrosion behaviors were evaluated by open-circuit potential (OCP), potentiodynamic polarization (PDP) and electrode impedance spectroscopy (EIS) tests in a 3.5 g/L NaCl solution. The results of PDP testing show that the corrosion potential of the MAO-coated galvanic pair was more positive than that of the uncoated galvanic pair and that the corrosion current density was smaller than that of the uncoated galvanic pair. EIS results show that the impedance of the galvanic pair increased after MAO coating. SEM images show that the corrosion damage of the uncoated Al alloy was more severe than that of the MAO-coated one, and the post-corrosion images of the surface of the 316L connected with MAO-coated Al alloy were more compact than those of the 316L connected with uncoated Al alloy. A physical model was developed to discuss the influence of MAO treatment on the galvanic corrosion process and corrosion mechanism.

  14. Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activity

    International Nuclear Information System (INIS)

    Schalling, D.; Aasberg, M.; Edman, G.; Oreland, L.

    1987-01-01

    The functional linkage between platelet MAO activity and psychopathology was explored by analyzing temperamental correlates in 40 male subjects by means of scales from the Eysenck Personality Questionnaire (EPQ), the Zuckerman Sensation Seeking Inventory, and the Karolinska Scales of Personality (KSP). Linear correlation were found with two sensation seeking scales, replicating earlier findings. However, nonlinear correlations predominated. Subjects with intemediate platelet MAO activity had higher scores in conformity scales and lower scores in anxiety and hostility scales than low and high MAO subgroups. Low MAO subjects showed a pattern of higher scores in KSP Impulsiveness, EPQ Neuroticism, and KSP Somatic Anxiety and Irritability and lower scores in KSP Socialization, in line with personality profiles found in alcoholics, phychopaths, and suicide attempters who also tend to have low platelet MAO activity. High MAO subject scored lower in sensation seeking and conformity scales and higher in KSP Phychasthenia, Muscular Tension and Suspicion scales, consistent with clinical links between high platelet MAO activity and anxiety and paranoia. (author)

  15. Inhibition of monoamine oxidase B (MAO-B) by Chinese herbal medicines.

    Science.gov (United States)

    Lin, R D; Hou, W C; Yen, K Y; Lee, M H

    2003-11-01

    Monoamine oxidase (MAO) catalyzes the oxidative deamination of biogenic amines accompaned by the release of H2O2. Two subtypes, MAO-A and MAO-B, exist on the basis of their specificities to substrates and inhibitors. The regulation of MAO-B activity is important in the treatment of neurodegenerative diseases. Twenty-seven species of plants used in traditional Chinese medicines, selected from an enthnobotanical survey, were used in an investigation of their inhibitory effect on MAO-B in rat brain homogenates. The 50% aqueous methanol extracts of four active extracts, Arisaema amurense, Lilium brownii var. colchesteri, Lycium chinense, and Uncaria rhynchophylla, exhibited the best activity and selectivity towards MAO-B with IC50 values of 0.44, 0.29, 0.40, and 0.03 mg/ml, respectively. A kinetic study of MAO-B inhibition by the four extracts using the Lineweaver-Burk plot for each active extract revealed the IC50 concentrations, and results show that: Ki = 0.59 mg/ml for A. amurense for the mixed-type mode, Ki = 0.58 mg/ml for L. brownii var. colchesteri for the mixed-type mode, Ki = 5.01 mg/ml for L. chinense for the uncompetitive mode, and Ki = 0.02 mg/ml for U. rhynchophylla for the uncompetitive mode. These may therefore be candidates for use in delaying the progressive degeneration caused by neurological diseases.

  16. Jonas Savimbi and UNITA's Struggle for Independence. An Application of Mao's Theory of Warfare?

    National Research Council Canada - National Science Library

    Nesbitt, Wanda L

    1997-01-01

    .... Using the key elements of Mao's theory, this paper will examine Savimbi's application of that theory and attempt to address the question of whether UNITA's failure to achieve control in Angola...

  17. ADHD and Disruptive behavior scores – associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents

    Directory of Open Access Journals (Sweden)

    Larsson Jan-Olov

    2008-04-01

    Full Text Available Abstract Background Pharmacological and genetic studies suggest the importance of the dopaminergic, serotonergic, and noradrenergic systems in the pathogenesis of Attention Deficit Hyperactivity Disorder (ADHD and Disruptive Behavior Disorder (DBD. We have, in a population-based sample, studied associations between dimensions of the ADHD/DBD phenotype and Monoamine Oxidase B (MAO-B activity in platelets and polymorphisms in two serotonergic genes: the Monoamine Oxidase A Variable Number of Tandem Repeats (MAO-A VNTR and the 5-Hydroxytryptamine Transporter gene-Linked Polymorphic Region (5-HTT LPR. Methods A population-based sample of twins, with an average age of 16 years, was assessed for ADHD/DBD with a clinical interview; Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL. Blood was drawn from 247 subjects and analyzed for platelet MAO-B activity and polymorphisms in the MAO-A and 5-HTT genes. Results We found an association in girls between low platelet MAO-B activity and symptoms of Oppositional Defiant Disorder (ODD. In girls, there was also an association between the heterozygote long/short 5-HTT LPR genotype and symptoms of conduct disorder. Furthermore the heterozygote 5-HTT LPR genotype in boys was found to be associated with symptoms of Conduct Disorder (CD. In boys, hemizygosity for the short MAO-A VNTR allele was associated with disruptive behavior. Conclusion Our study suggests that the serotonin system, in addition to the dopamine system, should be further investigated when studying genetic influences on the development of Disruptive Behavior Disorders.

  18. Analysis of monoamine oxidase (MAO) enzymatic activity by high-performance liquid chromatography-diode array detection combined with an assay of oxidation with a peroxidase and its application to MAO inhibitors from foods and plants.

    Science.gov (United States)

    Herraiz, Tomás; Flores, Andrea; Fernández, Lidia

    2018-01-15

    Monoamine oxidase (MAO) enzymes catalyze the oxidative deamination of biogenic amines and neurotransmitters and produce ammonia, aldehydes, and hydrogen peroxide which is involved in oxidative processes. Inhibitors of MAO-A and -B isozymes are useful as antidepressants and neuroprotectants. The assays of MAO usually measure amine oxidation products or hydrogen peroxide by spectrophotometric techniques. Those assays are often compromised by interfering compounds resulting in poor results. This research describes a new method that combines in the same assay the oxidative deamination of kynuramine to 4-hydroxyquinoline analyzed by HPLC-DAD with the oxidation of tetramethylbenzidine (TMB) (or Amplex Rex) by horseradish peroxidase (HRP) in presence of hydrogen peroxide. The new method was applied to study the inhibition of human MAO-A and -B by bioactive compounds including β-carboline alkaloids and flavonoids occurring in foods and plants. As determined by HPLC-DAD, β-carbolines, methylene blue, kaempferol and clorgyline inhibited MAO-A and methylene blue, 5-nitroindazole, norharman and deprenyl inhibited MAO-B, and all of them inhibited the oxidation of TMB in the same extent. The flavonoids catechin and cyanidin were not inhibitors of MAO by HPLC-DAD but highly inhibited the oxidation of TMB (or Amplex Red) by peroxidase whereas quercetin and resveratrol were moderate inhibitors of MAO-A by HPLC-DAD, but inhibited the peroxidase assay in a higher level. For some phenolic compounds, using the peroxidase-coupled assay to measure MAO activity led to mistaken results. The new method permits to discern between true inhibitors of MAO from those that are antioxidants and which interfere with peroxidase assays but do not inhibit MAO. For true inhibitors of MAO, inhibition as determined by HPLC-DAD correlated well with inhibition of the oxidation of TMB and this approach can be used to assess the in vitro antioxidant activity (less hydrogen peroxide production) resulting

  19. Tribological properties of duplex MAO/DLC coatings on magnesium alloy using combined microarc oxidation and filtered cathodic arc deposition

    International Nuclear Information System (INIS)

    Liang Jun; Wang Peng; Hu Litian; Hao Jingcheng

    2007-01-01

    The combined microarc oxidation (MAO) and filtered cathode arc deposition process was used to deposit duplex MAO/DLC coating on AM60B magnesium alloy. The microstructure and composition of the resulting duplex coating were analyzed by Raman spectroscopy, X-ray photoelectron spectroscope (XPS) and scanning electron microscope (SEM). The tribological behaviors of the duplex coating were studied by ball-on-disk friction testing. It is found that the Ti-doped DLC thin film could be successfully deposited onto the polished MAO coating. The duplex MAO/DLC coating exhibits a better tribological property than the DLC or MAO monolayer on Mg alloy substrate, owing to the MAO coating served as an intermediate layer provides improved load support for the soft Mg alloy substrate and the DLC top coating exhibits low friction coefficient

  20. Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

    Directory of Open Access Journals (Sweden)

    Sherine N. Khattab

    2015-09-01

    Full Text Available Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity.

  1. The preparation and corrosion behaviors of MAO coating on AZ91D with rare earth conversion precursor film

    International Nuclear Information System (INIS)

    Cai Jingshun; Cao Fahe; Chang Linrong; Zheng Junjun; Zhang Jianqing; Cao Chunan

    2011-01-01

    A novel kind of micro-arc oxidation (MAO) coating was prepared on magnesium alloy surface coated with rare earth conversion film (RE-film) in an alkaline aluminum oxidation electrolyte by AC power source. Inspection of scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared (FTIR) microspectroscopy, the structure and composition of MAO coating formed on AZ91D with RE-film under different applied voltages were investigated and the performance of the optimized MAO coating compared with the MAO coating directly formed on magnesium alloy. As the pretreatment of magnesium alloy with RE-film, the cerium oxides can be incorporated into the MAO coatings, reduce porosity of the MAO coating surface and enhance the thickness of MAO coating. These structure features and the cerium oxides incorporated into the MAO coating result in greatly improved corrosion resistance. Base on electrochemistry impedance spectroscopy (EIS) measurement, the electronic structure and composition analysis of the MAO coating, a double-layer structure, with a compact inner layer and a porous outer layer, of the coating was proposed for understanding its corrosion process.

  2. The preparation and corrosion behaviors of MAO coating on AZ91D with rare earth conversion precursor film

    Energy Technology Data Exchange (ETDEWEB)

    Cai Jingshun [Department of Chemistry, Zhejiang University, Zheda Road 38, Hangzhou, Zhejiang 310027 (China); Cao Fahe, E-mail: nelson_cao@zju.edu.cn [Department of Chemistry, Zhejiang University, Zheda Road 38, Hangzhou, Zhejiang 310027 (China); Chang Linrong; Zheng Junjun [Department of Chemistry, Zhejiang University, Zheda Road 38, Hangzhou, Zhejiang 310027 (China); Zhang Jianqing; Cao Chunan [Department of Chemistry, Zhejiang University, Zheda Road 38, Hangzhou, Zhejiang 310027 (China); State Key Laboratory for Corrosion and Protection, Institute of Metal Research, The Chinese Academy of Sciences, Shenyang 110016 (China)

    2011-02-01

    A novel kind of micro-arc oxidation (MAO) coating was prepared on magnesium alloy surface coated with rare earth conversion film (RE-film) in an alkaline aluminum oxidation electrolyte by AC power source. Inspection of scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared (FTIR) microspectroscopy, the structure and composition of MAO coating formed on AZ91D with RE-film under different applied voltages were investigated and the performance of the optimized MAO coating compared with the MAO coating directly formed on magnesium alloy. As the pretreatment of magnesium alloy with RE-film, the cerium oxides can be incorporated into the MAO coatings, reduce porosity of the MAO coating surface and enhance the thickness of MAO coating. These structure features and the cerium oxides incorporated into the MAO coating result in greatly improved corrosion resistance. Base on electrochemistry impedance spectroscopy (EIS) measurement, the electronic structure and composition analysis of the MAO coating, a double-layer structure, with a compact inner layer and a porous outer layer, of the coating was proposed for understanding its corrosion process.

  3. Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer.

    Science.gov (United States)

    Bharti, Rashmi; Dey, Goutam; Das, Anjan Kumar; Mandal, Mahitosh

    2018-04-26

    Monoamine oxidases (MAO) are mitochondrial enzymes functioning in oxidative metabolism of monoamines. The action of MAO-A has been typically described in neuro-pharmacological domains. Here, we have established a co-relation between IL-6/IL-6R and MAO-A and their regulation in hypoxia induced invasion/angiogenesis. We employed various in-vitro and in-vivo techniques and clinical samples. We studied a co-relation among MAO-A and IL-6/IL-6R and tumour angiogenesis/invasion in hypoxic environment in breast cancer model. Activation of IL-6/IL-6R and its downstream was found in hypoxic cancer cells. This elevation of IL-6/IL-6R caused sustained inhibition of MAO-A in hypoxic environment. Inhibition of IL-6R signalling or IL-6R siRNA increased MAO-A activity and inhibited tumour angiogenesis and invasion significantly in different models. Further, elevation of MAO-A with 5-azacytidine (5-Aza) modulated IL-6 mediated angiogenesis and invasive signatures including VEGF, MMPs and EMT in hypoxic breast cancer. High grade invasive ductal carcinoma (IDC) clinical specimen displayed elevated level of IL-6R and depleted MAO-A expression. Expression of VEGF and HIF-1α was unregulated and loss of E-Cadherin was observed in high grade IDC tissue specimen. Suppression of MAO-A by IL-6/IL-6R activation promotes tumour angiogenesis and invasion in hypoxic breast cancer environment.

  4. Degradation behavior of n-MAO/EPD bio-ceramic composite coatings on magnesium alloy in simulated body fluid

    Energy Technology Data Exchange (ETDEWEB)

    Xiong, Ying, E-mail: yxiong@zjut.edu.cn [College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310032 (China); Lu, Chao [College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310032 (China); Wang, Chao; Song, Renguo [School of Materials Science and Engineering, Changzhou University, Changzhou 213164 (China); Jiangsu Key Laboratory of Materials Surface Science and Technology, Changzhou University, Changzhou 213164 (China)

    2015-03-15

    Highlights: • A bio-ceramic n-MAO/EPD coating was prepared by combined MAO and EPD technique. • The precipitates of Ca/P compound are formed on the surface samples during immersion. • The n-MAO/EPD coating with HA dense structure has a favorable anti-corrosion effect. • Two degradation mechanism models for the n-MAO and n-MAO/EPD coating were proposed. - Abstract: The bio-ceramic composite coatings have been fabricated on ZK60 magnesium (Mg) alloy to improve its bio-corrosion resistance in a simulated body fluid (SBF). Firstly, micro-arc oxidation coatings (n-MAO coating) with the addition of zirconium oxide (ZrO{sub 2}) and cerium oxide (CeO{sub 2}) nano-particles were prepared by MAO technique on ZK60Mg alloy in alkaline electrolyte. Secondly, nano-hydroxyapatite (HA) was deposited on the surface of n-MAO coatings by using electrophoretic deposition (EPD) technique. The degradation behavior of the coated samples was investigated by means of immersion tests and electrochemical impedance spectroscopy (EIS) in the SBF at 36.5 ± 0.5 °C. The variation of phase composition, surface and cross-section morphology of coatings at different immersion stages were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEM), respectively. The results showed that the precipitation layer with biological activity formed on the surface of coated samples during the SBF immersion, which can inhibit Mg alloys from degrading effectively. The n-MAO/EPD composite coating with HA dense structure has a favorable anti-corrosion effect compared to the n-MAO coating. Degradation mechanism model of the corrosion process at different corrosion stages for two kinds of coatings were proposed. The long-term corrosion protection of the n-MAO/EPD composite coating was governed significantly by the synergistic effect of phase composition stability and micro structural integrity.

  5. Degradation behavior of n-MAO/EPD bio-ceramic composite coatings on magnesium alloy in simulated body fluid

    International Nuclear Information System (INIS)

    Xiong, Ying; Lu, Chao; Wang, Chao; Song, Renguo

    2015-01-01

    Highlights: • A bio-ceramic n-MAO/EPD coating was prepared by combined MAO and EPD technique. • The precipitates of Ca/P compound are formed on the surface samples during immersion. • The n-MAO/EPD coating with HA dense structure has a favorable anti-corrosion effect. • Two degradation mechanism models for the n-MAO and n-MAO/EPD coating were proposed. - Abstract: The bio-ceramic composite coatings have been fabricated on ZK60 magnesium (Mg) alloy to improve its bio-corrosion resistance in a simulated body fluid (SBF). Firstly, micro-arc oxidation coatings (n-MAO coating) with the addition of zirconium oxide (ZrO 2 ) and cerium oxide (CeO 2 ) nano-particles were prepared by MAO technique on ZK60Mg alloy in alkaline electrolyte. Secondly, nano-hydroxyapatite (HA) was deposited on the surface of n-MAO coatings by using electrophoretic deposition (EPD) technique. The degradation behavior of the coated samples was investigated by means of immersion tests and electrochemical impedance spectroscopy (EIS) in the SBF at 36.5 ± 0.5 °C. The variation of phase composition, surface and cross-section morphology of coatings at different immersion stages were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEM), respectively. The results showed that the precipitation layer with biological activity formed on the surface of coated samples during the SBF immersion, which can inhibit Mg alloys from degrading effectively. The n-MAO/EPD composite coating with HA dense structure has a favorable anti-corrosion effect compared to the n-MAO coating. Degradation mechanism model of the corrosion process at different corrosion stages for two kinds of coatings were proposed. The long-term corrosion protection of the n-MAO/EPD composite coating was governed significantly by the synergistic effect of phase composition stability and micro structural integrity

  6. Structure reveals regulatory mechanisms of a MaoC-like hydratase from Phytophthora capsici involved in biosynthesis of polyhydroxyalkanoates (PHAs).

    Science.gov (United States)

    Wang, Huizheng; Zhang, Kai; Zhu, Jie; Song, Weiwei; Zhao, Li; Zhang, Xiuguo

    2013-01-01

    Polyhydroxyalkanoates (PHAs) have attracted increasing attention as "green plastic" due to their biodegradable, biocompatible, thermoplastic, and mechanical properties, and considerable research has been undertaken to develop low cost/high efficiency processes for the production of PHAs. MaoC-like hydratase (MaoC), which belongs to (R)-hydratase involved in linking the β-oxidation and the PHA biosynthetic pathways, has been identified recently. Understanding the regulatory mechanisms of (R)-hydratase catalysis is critical for efficient production of PHAs that promise synthesis an environment-friendly plastic. We have determined the crystal structure of a new MaoC recognized from Phytophthora capsici. The crystal structure of the enzyme was solved at 2.00 Å resolution. The structure shows that MaoC has a canonical (R)-hydratase fold with an N-domain and a C-domain. Supporting its dimerization observed in structure, MaoC forms a stable homodimer in solution. Mutations that disrupt the dimeric MaoC result in a complete loss of activity toward crotonyl-CoA, indicating that dimerization is required for the enzymatic activity of MaoC. Importantly, structure comparison reveals that a loop unique to MaoC interacts with an α-helix that harbors the catalytic residues of MaoC. Deletion of the loop enhances the enzymatic activity of MaoC, suggesting its inhibitory role in regulating the activity of MaoC. The data in our study reveal the regulatory mechanism of an (R)-hydratase, providing information on enzyme engineering to produce low cost PHAs.

  7. Structure reveals regulatory mechanisms of a MaoC-like hydratase from Phytophthora capsici involved in biosynthesis of polyhydroxyalkanoates (PHAs.

    Directory of Open Access Journals (Sweden)

    Huizheng Wang

    Full Text Available Polyhydroxyalkanoates (PHAs have attracted increasing attention as "green plastic" due to their biodegradable, biocompatible, thermoplastic, and mechanical properties, and considerable research has been undertaken to develop low cost/high efficiency processes for the production of PHAs. MaoC-like hydratase (MaoC, which belongs to (R-hydratase involved in linking the β-oxidation and the PHA biosynthetic pathways, has been identified recently. Understanding the regulatory mechanisms of (R-hydratase catalysis is critical for efficient production of PHAs that promise synthesis an environment-friendly plastic.We have determined the crystal structure of a new MaoC recognized from Phytophthora capsici. The crystal structure of the enzyme was solved at 2.00 Å resolution. The structure shows that MaoC has a canonical (R-hydratase fold with an N-domain and a C-domain. Supporting its dimerization observed in structure, MaoC forms a stable homodimer in solution. Mutations that disrupt the dimeric MaoC result in a complete loss of activity toward crotonyl-CoA, indicating that dimerization is required for the enzymatic activity of MaoC. Importantly, structure comparison reveals that a loop unique to MaoC interacts with an α-helix that harbors the catalytic residues of MaoC. Deletion of the loop enhances the enzymatic activity of MaoC, suggesting its inhibitory role in regulating the activity of MaoC.The data in our study reveal the regulatory mechanism of an (R-hydratase, providing information on enzyme engineering to produce low cost PHAs.

  8. Ķīniešu tradīcijas un Mao Dzeduns: Mao „ci” dzeju interpretācija

    OpenAIRE

    Komova, Ņina

    2010-01-01

    Bakalaura darba tēma ir “Ķīniešu tradīcija un Mao Dzeduns: Mao “ci” dzeju interpretācija”. Šajā darba tiek aplūkota Mao Dzeduna dzeja, kādus dzejoļus viņš rakstīja, kādas bija galvenās tēmas viņā dzejā, kā arī daži no viņa dzejoļu tulkojumi. Šajā laikā cilvēkiem ir izveidojusies liela interese par Ķīnas kultūru, jo īpaši ir interese par literatūru un dzeju. Senā ķīniešu dzeja ir plaši aplūkota arī Latvijā. Ir iztulkoti un komentēti Li Bo darbi, kā arī citi seno ķīniešu autoru darbi. Iz...

  9. Crystallization and preliminary X-ray analysis of the MaoC-like dehydratase from Phytophthora capsici

    International Nuclear Information System (INIS)

    Wang, Huizheng; Guo, Jiubiao; Pang, Hai; Zhang, Xiuguo

    2010-01-01

    The MaoC-like dehydratase from P. capsici was cloned, expressed and purified to homogeneity. Crystals were obtained that diffracted to 1.93 Å resolution. MaoC-like dehydratase (MaoC) plays an important role in supplying (R)-3-hydroxyacyl-CoA from the fatty-acid oxidation pathway to polyhydroxyalkanoate (PHA) biosynthetic pathways. PHAs have been attracting much attention as they can be used in the biosynthesis of synthetic plastics. Crystals of MaoC from Phytophora capsici were grown by the hanging-drop vapour-diffusion method at 289 K in a number of screening conditions. An MaoC crystal diffracted to 1.93 Å resolution using X-ray radiation and belonged to the orthorhombic space group P2 1 2 1 2 1 , with unit-cell parameters a = 81.458, b = 82.614, c = 124.228 Å, α = β = γ = 90°

  10. MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull

    DEFF Research Database (Denmark)

    Saaby, Lasse; Rasmussen, Hasse Bonde; Jäger, Anna Katharina

    2009-01-01

    AIM OF THE STUDY: This study investigated MAO-A inhibitory activity of methanol extract of Calluna vulgaris (L.) Hull., which traditionally has been used as a nerve calming remedy. MATERIALS AND METHODS: A methanolic extract of Calluna vulgaris was partitioned against heptane, ethyl acetate...

  11. A primary study on texture modification and proteolysis of mao-tofu ...

    African Journals Online (AJOL)

    Proteolysis occurred during fermentation was evaluated by SDS-PAGE and chemical analysis. Results from Texture Profile Analysis showed that adhesiveness of mao-tofu had an increase trend while hardness, cohesiveness and springiness had a decrease trend as fermentation progressed. SEM analysis showed that the ...

  12. Gandhi and Mao on manual labour in the school: A retrospective analysis

    Science.gov (United States)

    Zachariah, Mathew; Hoffman, Arlene

    1985-12-01

    Mahatma Gandhi's views on relating the world of formal education to the world of work were developed first in his experimental `Tolstoy Farm' in South Africa. On his return to India, Gandhi insisted that a required manual labour component in the curriculum would help regenerate India's village economy, develop in India's children a deeper understanding of India's cultural roots, motivate children to relate `book learning' to life in society, and destroy invidious caste distinctions. The major proposals and suggestions in Gandhi's writing will be discussed in the context of his hopes for using schooling as an agent of progress in India. Mao Ze-Dong's views, on the other hand, were developed in the context of his Yenan experience in the 1930s, i.e. the decision to consolidate a power base in the interior of China before waging a class war against the landlords and capitalists of China. Mao's views were also, to some extent, rooted in the Chinese reality of stagnant, poverty-stricken rural areas. But, Mao's writings indicate that Marxist hopes to relate theory and practice (as understood in dialectical materialism) and to ensure that everyone participated in mental as well as manual labour in a socialist society had led him to formulate his proposals. Both Gandhi's and Mao's views and proposals have been more or less abandoned in India and China respectively. The similar and dissimilar reasons which led to such a fate are examined in this retrospective analysis.

  13. Microstructure and properties of duplex (Ti:N)-DLC/MAO coating on magnesium alloy

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Wei; Ke, Peiling [Ningbo Key Laboratory of Marine Protection Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201 (China); Fang, Yong [Sir Run Run Shaw Hospital, School of Medicine, Zhe Jiang University, Zhejiang 310016 (China); Zheng, He [Ningbo Key Laboratory of Marine Protection Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201 (China); Wang, Aiying, E-mail: aywang@nimte.ac.cn [Ningbo Key Laboratory of Marine Protection Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201 (China)

    2013-04-01

    Ti and N co-doped diamond-like carbon ((Ti:N)-DLC) film was deposited on the MAO coated substrate using a hybrid beam deposition system, which consists of a DC magnetron sputtering of Ti target and a linear ion source (LIS) with C{sub 2}H{sub 2} and N{sub 2} precursor gas. The microstructure and properties of the duplex (Ti:N)-DLC/MAO coating were investigated. Results indicate that the (Ti:N)-DLC top film with TiN crystalline phase was formed. Ti and N co-doping resulted in the increasing I{sub D}/I{sub G} ratio. The significant improvement in the wear and corrosion resistance of duplex (Ti:N)-DLC/MAO coating was mainly attributed to the increased binding strength, lubrication characteristics and chemical inertness of (Ti:N)-DLC top film. The superior low-friction and anti-corrosion properties of duplex (Ti:N)-DLC/MAO coating make it a good candidate as protective coating on magnesium alloy.

  14. Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla.

    Science.gov (United States)

    Hou, Wen-Chi; Lin, Rong-Dih; Chen, Cheng-Tang; Lee, Mei-Hsien

    2005-08-22

    Attenuation of monoamine oxidase B (MAO-B) activity may provide protection against oxidative neurodegeneration. For this reason, inhibition of MAO-B activity is used as part of the treatment of Parkinson's and Alzheimer's patients. The hook of Uncaria rhynchophylla (Miq.) Jacks. (Rubiaceae) is a traditional Chinese herbal drug that is generally used to treat convulsive disorders. In this study, the fractionation and purification of Uncaria rhynchophylla extracts using a bioguided assay isolated two known compounds, (+)-catechin and (-)-epicatechin. The compounds inhibited MAO-B, as measured by an assay of rat brain MAO-B separated by electrophoresis on a 7.5% native polyacrylamide gel. The IC(50) values of (+)-catechin and (-)-epicatechin were 88.6 and 58.9 microM, respectively, and inhibition occurred in a dose-dependent manner, as measured by the fluorescence method. The Lineweaver-Burk plot revealed K(i) values for (+)-catechin and (-)-epicatechin of 74 and 21 microM, respectively. This suggests that these two compounds, isolated here for the first time from Uncaria rhynchophylla, might be able to protect against neurodegeneration in vitro, and, therefore, the molecular mechanism deserves further study. This finding may also increase interest in the health benefits of Uncaria rhynchophylla.

  15. The n-MAO/EPD bio-ceramic composite coating fabricated on ZK60 magnesium alloy using combined micro-arc oxidation with electrophoretic deposition

    Energy Technology Data Exchange (ETDEWEB)

    Xiong, Ying, E-mail: yxiong@zjut.edu.cn [College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310032 (China); Lu, Chao [College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310032 (China); Wang, Chao; Song, Renguo [School of Materials Science and Engineering, Changzhou University, Changzhou 213164 (China); Jiangsu Key Laboratory of Materials Surface Science and Technology, Changzhou University, Changzhou 213164 (China)

    2014-12-15

    Highlights: • Adding CeO{sub 2}/ZrO{sub 2} nano-particles to modify the properties of n-MAO coating. • A bio-ceramic n-MAO/EPD composite coating was prepared by two-step methods. • The n-MAO/EPD composite coating with HA has a favorable anti-corrosion effect. - Abstract: A bio-ceramic composite coating was fabricated on ZK60 magnesium (Mg) alloy using combined micro-arc oxidation (MAO) with electrophoretic deposition (EPD) technique. The MAO coating as the basal layer was produced in alkaline electrolyte with (n-MAO coating) and without (MAO coating) the addition of CeO{sub 2} and ZrO{sub 2} nano-particles, respectively. A hydroxyapatite (HA) coating as the covering layer was deposited on the n-MAO coating to improve the biological properties of the coating (n-MAO/EPD composite coating). The morphology and phase composition of three treated coatings were investigated by scanning electron microscope (SEM) and X-ray diffraction (XRD). The corrosion resistance of these coatings was evaluated with potentiodynamic polarization tests and immersion tests in simulated body fluid (SBF) at 36.5 ± 0.5 °C. The XRD spectra showed that the CeO{sub 2} and ZrO{sub 2} peaks can be collected in the n-MAO coating, and HA particles exists in the n-MAO/EPD composite coating. The results of corrosion tests indicated that the n-MAO/EPD composite coating owned increased bioactivity and long-term protective ability compared with the MAO coating and the n-MAO coating. Thus Mg alloy coated with the n-MAO/EPD composite coating should be more suited as biodegradable bone implants.

  16. Are MAO-A deficiency states in the general population and in putative high-risk populations highly uncommon?

    Science.gov (United States)

    Murphy, D L; Sims, K; Eisenhofer, G; Greenberg, B D; George, T; Berlin, F; Zametkin, A; Ernst, M; Breakefield, X O

    1998-01-01

    Lack of monoamine oxidase A (MAO-A) due to either Xp chromosomal deletions or alterations in the coding sequence of the gene for this enzyme are associated with marked changes in monoamine metabolism and appear to be associated with variable cognitive deficits and behavioral changes in humans and in transgenic mice. In mice, some of the most marked behavioral changes are ameliorated by pharmacologically-induced reductions in serotonin synthesis during early development, raising the question of possible therapeutic interventions in humans with MAO deficiency states. At the present time, only one multi-generational family and a few other individuals with marked MAO-A deficiency states have been identified and studied in detail. Although MAO deficiency states associated with Xp chromosomal deletions were identified by distinct symptoms (including blindness in infancy) produced by the contiguous Norrie disease gene, the primarily behavioral phenotype of individuals with the MAO mutation is less obvious. This paper reports a sequential research design and preliminary results from screening several hundred volunteers in the general population and from putative high-risk groups for possible MAO deficiency states. These preliminary results suggest that marked MAO deficiency states are very rare.

  17. Real-time motion-adaptive-optimization (MAO) in TomoTherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lu Weiguo; Chen Mingli; Ruchala, Kenneth J; Chen Quan; Olivera, Gustavo H [TomoTherapy Inc., 1240 Deming Way, Madison, WI (United States); Langen, Katja M; Kupelian, Patrick A [MD Anderson Cancer Center-Orlando, Orlando, FL (United States)], E-mail: wlu@tomotherapy.com

    2009-07-21

    IMRT delivery follows a planned leaf sequence, which is optimized before treatment delivery. However, it is hard to model real-time variations, such as respiration, in the planning procedure. In this paper, we propose a negative feedback system of IMRT delivery that incorporates real-time optimization to account for intra-fraction motion. Specifically, we developed a feasible workflow of real-time motion-adaptive-optimization (MAO) for TomoTherapy delivery. TomoTherapy delivery is characterized by thousands of projections with a fast projection rate and ultra-fast binary leaf motion. The technique of MAO-guided delivery calculates (i) the motion-encoded dose that has been delivered up to any given projection during the delivery and (ii) the future dose that will be delivered based on the estimated motion probability and future fluence map. These two pieces of information are then used to optimize the leaf open time of the upcoming projection right before its delivery. It consists of several real-time procedures, including 'motion detection and prediction', 'delivered dose accumulation', 'future dose estimation' and 'projection optimization'. Real-time MAO requires that all procedures are executed in time less than the duration of a projection. We implemented and tested this technique using a TomoTherapy (registered) research system. The MAO calculation took about 100 ms per projection. We calculated and compared MAO-guided delivery with two other types of delivery, motion-without-compensation delivery (MD) and static delivery (SD), using simulated 1D cases, real TomoTherapy plans and the motion traces from clinical lung and prostate patients. The results showed that the proposed technique effectively compensated for motion errors of all test cases. Dose distributions and DVHs of MAO-guided delivery approached those of SD, for regular and irregular respiration with a peak-to-peak amplitude of 3 cm, and for medium and large

  18. Development of positron tracer for in vivo estimation of brain MAO-B activity

    International Nuclear Information System (INIS)

    Inoue, Osamu; Tominaga, Toshiyoshi; Fukuda, Nobuo; Suzuki, Kazutoshi; Yamasaki, Toshio

    1984-01-01

    Both the specificity and the measurable range of enzyme activity of this method were found to be much dependent upon the enzymatic properties of substrate-tracer. The measurable range of brain enzyme activity was found to be from zero to the maximum value which was dependent upon two factors; the elimination rate of substratetracer from the brain (Ksub(el)) and the Vsub(max)/Ksub(m) value of substrate. The detectable range of changes in enzyme activity can be made wider by using another substrate as a tracer which has a lower Vsub(max)/Ksub(m) value or larger Ksub(el) value. The specificity can be also favorably designed by selection of substrate with various enzymatic or physico-chemical properties as a tracer. N, N-dimethyl phenylethylamine (DMPEA) was selected as a substrate-tracer for the estimation of brain MAO-B activity. Very high accumulation of radioactivity into mouse brain at 1 min after intravenous injection of 11 C-DMPEA, and a long-term retention of radioactivity in the brain were observed. 11 C-DMPEA seemed to be metabolized to 11 C-dimethylamine by brain MAO, and be trapped by the blood-brain barrier. When various dosage of 1-deprenyl (a specific MAO-B inhibitor) were pretreated, brain radioactivity at 1 hr after injection of 11 C-DMPEA significantly decreased in a dosage (1-deprenyl)-dependent way, while pretreatment with clorgyline (a specific MAO-A inhibitor) had no effect. This decrease in radioactivity might be due to the decrease of the production rate of labeled metabolite ( 11 C-dimethylamine) in the brain. The relationship between the radioactivity remaining at 1 hr after injection and MAO-B activity remaining in the brain was quite paralle. 11 C-DMPEA seems to be a specific radiotracer for the external detection of alterations in MAO-B activity in the brain with a fair sensitivity. (J.P.N.)

  19. Real-time motion-adaptive-optimization (MAO) in TomoTherapy

    International Nuclear Information System (INIS)

    Lu Weiguo; Chen Mingli; Ruchala, Kenneth J; Chen Quan; Olivera, Gustavo H; Langen, Katja M; Kupelian, Patrick A

    2009-01-01

    IMRT delivery follows a planned leaf sequence, which is optimized before treatment delivery. However, it is hard to model real-time variations, such as respiration, in the planning procedure. In this paper, we propose a negative feedback system of IMRT delivery that incorporates real-time optimization to account for intra-fraction motion. Specifically, we developed a feasible workflow of real-time motion-adaptive-optimization (MAO) for TomoTherapy delivery. TomoTherapy delivery is characterized by thousands of projections with a fast projection rate and ultra-fast binary leaf motion. The technique of MAO-guided delivery calculates (i) the motion-encoded dose that has been delivered up to any given projection during the delivery and (ii) the future dose that will be delivered based on the estimated motion probability and future fluence map. These two pieces of information are then used to optimize the leaf open time of the upcoming projection right before its delivery. It consists of several real-time procedures, including 'motion detection and prediction', 'delivered dose accumulation', 'future dose estimation' and 'projection optimization'. Real-time MAO requires that all procedures are executed in time less than the duration of a projection. We implemented and tested this technique using a TomoTherapy (registered) research system. The MAO calculation took about 100 ms per projection. We calculated and compared MAO-guided delivery with two other types of delivery, motion-without-compensation delivery (MD) and static delivery (SD), using simulated 1D cases, real TomoTherapy plans and the motion traces from clinical lung and prostate patients. The results showed that the proposed technique effectively compensated for motion errors of all test cases. Dose distributions and DVHs of MAO-guided delivery approached those of SD, for regular and irregular respiration with a peak-to-peak amplitude of 3 cm, and for medium and large prostate motions. The results conceptually

  20. Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease.

    Science.gov (United States)

    Neudorfer, Catharina; Shanab, Karem; Jurik, Andreas; Schreiber, Veronika; Neudorfer, Carolina; Vraka, Chrysoula; Schirmer, Eva; Holzer, Wolfgang; Ecker, Gerhard; Mitterhauser, Markus; Wadsak, Wolfgang; Spreitzer, Helmut

    2014-09-15

    Since high MAO-B levels are present in early stages of AD, the MAO-B system can be designated as an appropriate and prospective tracer target of molecular imaging biomarkers for the detection of early AD. According to the preceding investigations of Mishra et al. the aim of this work was the development of a compound library of selective and reversible MAO-B inhibitors by performing bioisosteric modifications of the core structure of 3-(anthracen-9-yl)-5-phenyl-4,5-dihydro-1H-pyrazoles. In conclusion, 13 new pyrazoline based derivatives have been prepared, which will serve as precursor substances for future radiolabeling as well as reference compounds for the investigation of increased MAO-B levels in AD. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. The MAO NASU Plate Archive: ``observations in the past'' of minor planets

    Science.gov (United States)

    Sergeeva, T. P.; Golovnya, V. V.; Sergeev, A. V.

    2005-06-01

    The Plate Archive of the Main Astronomical Observatory of the National Academy of Sciences of Ukraine (MAO NASU) includes 20 thousands of direct sky area plates, which have been taken for various astronomical projects during the period of about 50 years. Those plates contain more then hundred thousand images of minor planets with magnitude up to 16.7m. About 10% of minor planets, which may be found on our archive plates were firstly discovered after the time when plates have been taken. So, we can rediscovery them due to the so-called ``observations in the past''. In the paper the criteria for choose of objects and methods of their search, identification, and determination of their position are discussed. First results of the search for potentially hazardous asteroids in the MAO plate archive are presented.

  2. Cultural Discontinuity In Post-Mao China: An Itinerant Ethnography Of McDonald's Beijing

    OpenAIRE

    Noel M. Murray

    2011-01-01

    Universalistic approaches cannot account for the diversity of culture in a rapidly changing post-communist society. Different age cohorts within countries may exhibit dissimilar values and behavioral orientations. This article lays a foundation for the use of broader philosophical and methodological frameworks for the study of culture in an age of globalization. Bourdieus concepts of habitus and hysteresis effect are described and applied to a study of post-Mao consumer food culture in China....

  3. Reversible Inhibitors of Monoamine Oxidase-A (RIMAs): Robust, Reversible Inhibition of Human Brain MAO-A by CX157

    Science.gov (United States)

    Fowler, Joanna S; Logan, Jean; Azzaro, Albert J; Fielding, Robert M; Zhu, Wei; Poshusta, Amy K; Burch, Daniel; Brand, Barry; Free, James; Asgharnejad, Mahnaz; Wang, Gene-Jack; Telang, Frank; Hubbard, Barbara; Jayne, Millard; King, Payton; Carter, Pauline; Carter, Scott; Xu, Youwen; Shea, Colleen; Muench, Lisa; Alexoff, David; Shumay, Elena; Schueller, Michael; Warner, Donald; Apelskog-Torres, Karen

    2010-01-01

    Reversible inhibitors of monoamine oxidase-A (RIMA) inhibit the breakdown of three major neurotransmitters, serotonin, norepinephrine and dopamine, offering a multi-neurotransmitter strategy for the treatment of depression. CX157 (3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin-10,10-dioxide) is a RIMA, which is currently in development for the treatment of major depressive disorder. We examined the degree and reversibility of the inhibition of brain monoamine oxidase-A (MAO-A) and plasma CX157 levels at different times after oral dosing to establish a dosing paradigm for future clinical efficacy studies, and to determine whether plasma CX157 levels reflect the degree of brain MAO-A inhibition. Brain MAO-A levels were measured with positron emission tomography (PET) imaging and [11C]clorgyline in 15 normal men after oral dosing of CX157 (20–80 mg). PET imaging was conducted after single and repeated doses of CX157 over a 24-h time course. We found that 60 and 80 mg doses of CX157 produced a robust dose-related inhibition (47–72%) of [11C]clorgyline binding to brain MAO-A at 2 h after administration and that brain MAO-A recovered completely by 24 h post drug. Plasma CX157 concentration was highly correlated with the inhibition of brain MAO-A (EC50: 19.3 ng/ml). Thus, CX157 is the first agent in the RIMA class with documented reversible inhibition of human brain MAO-A, supporting its classification as a RIMA, and the first RIMA with observed plasma levels that can serve as a biomarker for the degree of brain MAO-A inhibition. These data were used to establish the dosing regimen for a current clinical efficacy trial with CX157. PMID:19890267

  4. The lasting impression of chairman Mao: hyperfidelity of familiar-face memory.

    Science.gov (United States)

    Ge, Liezhong; Luo, Jing; Nishimura, Mayu; Lee, Kang

    2003-01-01

    We examined the accuracy of a highly-familiar-face representation in memory. In experiment 1, a famous portrait of Chairman Mao was digitally altered in terms of the distance between his two eyes, two pixels at a time. Mainland Chinese adults were shown the original or altered photos, one at a time, and asked to determine whether each was that of Chairman Mao or altered. Eastern Asian and Caucasian participants, who were unfamiliar with Mao's photo, were shown simultaneously the original face paired with the altered ones and asked to determine whether the photos were identical. The Mainland Chinese participants' memory threshold approximated the perceptual discrimination threshold of the Eastern Asian and Caucasian participants. Experiments 2 and 3 ruled out that the result of experiment I was due to artifacts of photographic alteration. The findings of the present study suggest that our memory of a very familiar face is highly accurate, at least in terms of the interocular configuration. The accuracy is perhaps only limited by the perceptual resolution capacity of our visual system.

  5. New coumarin derivatives: design, synthesis and use as inhibitors of hMAO.

    Science.gov (United States)

    He, Xu; Chen, Yan-Yan; Shi, Jing-Bo; Tang, Wen-Jiang; Pan, Zhi-Xiang; Dong, Zhi-Qiang; Song, Bao-An; Li, Jun; Liu, Xin-Hua

    2014-07-15

    A series new 2H-chromene-3-carboxamides (4a-4i) and S-2H-chromene-3-carbothioates (5j-5t) were synthesized and evaluated as monoamine oxidase A and B inhibitors. Among them, compound 5k (IC50=0.21μM, IC50 iproniazid=7.65μM) showed the most activity and higher MAO-B selectivity (189.2-fold vs 1-fold) with respect to the MAO-A isoform. The need to clarify at a 3D level some important molecular aspects of discussed SAR, we undertaked a number of docking simulations to better assess. The steric effect was analyzed interms of both posing and scoring by investigating the nature of the binding interactions. The docking results of active compound 5k with hMAO-B complex indicated that conserved residue ILE 199 was important for ligand binding via Sigma-Pi interaction. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Mao Dzeduna personības ietekme uz Ķīnas tautu un kultūru

    OpenAIRE

    Skrinda, Ramona

    2008-01-01

    Darbā „Mao Dzeduna personības ietekme uz Ķīnas Tautu un kultūru” tiek aplūkoti Mao Dzeduna personības un uzskatu veidošanās apstākļi, izpētot tā laika politisko atmosfēru valstī, Mao izcelsmi, skolas gaitas, jaunības gadus. Tiek apskatīta arī Mao varas biogrāfija līdz Tautas Republikas proklamēšanas brīdim. Lai gūtu pilnīgāku priekšstatu par Mao Dzeduna personību tiek sniegts arī ģimenes dzīves apskats- Mao četras sievas un viņa attieksme pret tām, kopīgie bērni un to liktenis. Tiek minēti ar...

  7. Corrosion and drug release properties of EN-plating/PLGA composite coating on MAO film

    International Nuclear Information System (INIS)

    Lu Ping; Liu Yin; Guo Meiqing; Fang Haidong; Xu Xinhua

    2011-01-01

    The electroless nickel plating/poly(DL-lactide-co-glycolide) composite coating (EN-plating/PLGA composite coating) was fabricated on the surface of the micro-arc oxidation (MAO) film of the magnesium alloy AZ81 to double control the corrosion and drug release in the hanks' solution. The EN-plating was fabricated on the MAO coating to improve the corrosion resistance by overlaying most pores and micro-cracks on the surface of the MAO film. Meanwhile, a double layered organic poly(DL-lactide-co-glycolide)/paclitaxel (PLGA/PTX) drug releasing coating with a top layered PLGA drug controlled releasing coating on EN plating was prepared to control the drug release rate by adjusting the different lactide: glycolide (LA:GA) ratio of PLGA. Scanning electron microscopy (SEM) and the X-ray powder diffraction (XRD) were used to analyze the morphology and the composition of the EN-plating. The corrosion behavior of the magnesium alloy substrate and the status of the drug in the PLGA matrix were respectively evaluated by Potentiodynamic polarization and Differential scanning calorimetry (DSC). The drug release was determined by ultraviolet-visible (UV-visible) spectrophotometer. EN-plating coating which was composed of compact cauliflower nodules was uniform in size and defect free with no pores or cracks. EN-plating could seal the microcracks and microholes on the outer layer of the MAO coating effectively. The corrosion resistance was improved by preventing the corrosive ions from diffusing to the magnesium alloy substrate. The drug release rate of PTX exhibited a nearly linear sustained-release profile with no significant burst releases. - Research highlights: → An organic and in organic EN-plating/PLGA composite coating was first fabricated on the surface of the MAO film. → This composite coating the magnesium alloy AZ81could double control the corrosion and drug release in the hanks' solution. → The drug release rate could be controlled by LG:GA ratio and the PTX

  8. Corrosion and drug release properties of EN-plating/PLGA composite coating on MAO film

    Energy Technology Data Exchange (ETDEWEB)

    Lu Ping [School of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072 (China); Liu Yin [Department of Cardiology, Tianjin Chest Hospital, Tianjin 300051 (China); Guo Meiqing; Fang Haidong [School of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072 (China); Xu Xinhua, E-mail: xhxu_tju@eyou.com [School of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072 (China)

    2011-10-10

    The electroless nickel plating/poly(DL-lactide-co-glycolide) composite coating (EN-plating/PLGA composite coating) was fabricated on the surface of the micro-arc oxidation (MAO) film of the magnesium alloy AZ81 to double control the corrosion and drug release in the hanks' solution. The EN-plating was fabricated on the MAO coating to improve the corrosion resistance by overlaying most pores and micro-cracks on the surface of the MAO film. Meanwhile, a double layered organic poly(DL-lactide-co-glycolide)/paclitaxel (PLGA/PTX) drug releasing coating with a top layered PLGA drug controlled releasing coating on EN plating was prepared to control the drug release rate by adjusting the different lactide: glycolide (LA:GA) ratio of PLGA. Scanning electron microscopy (SEM) and the X-ray powder diffraction (XRD) were used to analyze the morphology and the composition of the EN-plating. The corrosion behavior of the magnesium alloy substrate and the status of the drug in the PLGA matrix were respectively evaluated by Potentiodynamic polarization and Differential scanning calorimetry (DSC). The drug release was determined by ultraviolet-visible (UV-visible) spectrophotometer. EN-plating coating which was composed of compact cauliflower nodules was uniform in size and defect free with no pores or cracks. EN-plating could seal the microcracks and microholes on the outer layer of the MAO coating effectively. The corrosion resistance was improved by preventing the corrosive ions from diffusing to the magnesium alloy substrate. The drug release rate of PTX exhibited a nearly linear sustained-release profile with no significant burst releases. - Research highlights: {yields} An organic and in organic EN-plating/PLGA composite coating was first fabricated on the surface of the MAO film. {yields} This composite coating the magnesium alloy AZ81could double control the corrosion and drug release in the hanks' solution. {yields} The drug release rate could be controlled by LG

  9. Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [11C]-harmine positron emission tomography study

    Science.gov (United States)

    Sacher, Julia; Rabiner, Eugenii A; Clark, Michael; Rusjan, Pablo; Soliman, Alexandra; Boskovic, Rada; Kish, Stephen J; Wilson, Alan A; Houle, Sylvain; Meyer, Jeffrey H

    2012-01-01

    Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (PMAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels. PMID:22186668

  10. Clinical evaluation of carbon-11-phenylephrine: MAO-sensitive marker of cardiac sympathetic neurons.

    Science.gov (United States)

    Raffel, D M; Corbett, J R; del Rosario, R B; Gildersleeve, D L; Chiao, P C; Schwaiger, M; Wieland, D M

    1996-12-01

    The sympathomimetic drug phenylephrine recently has been labeled with 11C for use in PET studies of cardiac sympathetic innervation. Previous reports using isolated perfused rat heart models indicate that phenylephrine is metabolized by intraneuronal monoamine oxidase (MAO). This report compares the imaging characteristics, neuronal selectivity and kinetics of (-)-[11C]phenylephrine (PHEN) to the structurally similar but MAO-resistant analog (-)-[11C]-meta-hydroxyephedrine (HED), an established heart neuronal marker. Fourteen healthy volunteers were studied with PET and PHEN. Ten had paired studies with HED; four of the 10 were scanned a second time with each tracer after oral administration of desipramine, a selective neuronal transport blocker. Hemodynamic and electrocardiographic responses were monitored. Blood levels of intact radiotracer and radiolabeled metabolites were determined from venous blood samples taken during the PET study. Myocardial retention indices for both tracers were calculated. No hemodynamic or electrocardiographic effects were observed with either tracer. PHEN showed reduced myocardial retention at 50 min compared to HED; however, image quality and uniformity of distribution were comparable. PHEN cleared from myocardium with a mean half-time of 59 +/- 5 min, while myocardial levels of HED remained constant. PHEN metabolites appeared in the blood approximately three times faster than HED metabolites. Desipramine pretreatment markedly reduced (> 60%) myocardial retention of both PHEN and HED. PHEN provides PET images of human heart comparable in quality and uniformity to HED. Like HED, PHEN localizes in the sympathetic nerves of the heart. However, the more rapid efflux of PHEN, that is likely mediated by MAO, may provide information on the functional status of cardiac sympathetic neurons unobtainable with HED.

  11. Preclinical profile of befloxatone, a new reversible MAO-A inhibitor.

    Science.gov (United States)

    Curet, O; Damoiseau-Ovens, G; Sauvage, C; Sontag, N; Avenet, P; Depoortere, H; Caille, D; Bergis, O; Scatton, B

    1998-12-01

    Befloxatone, a novel oxazolidinone derivative, is a potent, selective and reversible monoamine oxidase A (MAO-A) inhibitor in vitro (K1A = 1.9-3.6 nM) and ex vivo (ED50 MAO-A = 0.02 mg/kg, p.o.). It does not interact with a large number of receptors, monoamine transporters or other amine oxidases. Binding studies with [3H]-befloxatone in rat brain sections show that it labels with high affinity (Kd = 1.3 nM) a single population of sites with the pharmacological characteristics and regional distribution of MAO-A. In the rat brain, befloxatone (0.75 mg/kg, i.p.) increases tissue levels of monoamines and decreases levels of their deaminated metabolites. Acute administration of befloxatone (0.75 mg/kg, i.p.) induces an increase in extracellular striatal dopamine and cortical norepinephrine but not cortical serotonin levels in the rat. Befloxatone (1 mg/kg, i.p.) potently inhibits the firing rate of serotonergic neurons, partially decreases the firing of noradrenergic neurons and has no effect on the firing of dopaminergic neurons (a mirror image of its effects on monoamine release in terminal regions), suggesting that the relative effects of befloxatone on monoamine release may be governed by autoreceptor-mediated control of monoaminergic neurons at the cell body level. Befloxatone (0.03-0.3 mg/kg, p.o.) exhibits potent activity in behavioural models predictive of antidepressant activity. Befloxatone (up to 1.5 mg/kg, p.o.) does not potentiate the pressor effects of orally administered tyramine at centrally active doses and duodenal [3H]-befloxatone binding is displaced by increasing doses of orally administered tyramine (0.1-40 mg/kg, i.p.). These results suggest that befloxatone is a potent reversible MAO-A inhibitor with antidepressant potential and a wide safety margin with regard to the potentiation of the pressor effect of tyramine.

  12. A lost chance? Birth control policies in the Mao's China (1949-1976

    Directory of Open Access Journals (Sweden)

    Daniel Gomá

    2010-12-01

    Full Text Available This article analyzes the birth control policies in China during the Maoist era (1949- 1976. Considering Chinese and foreign sources, it is explained how the different campaigns of family planning took place and how these campaigns were subjected positively and negatively to the policies of the supreme leader Mao Zedong. Although only the last one had a real impact on the fight against overpopulation, all campaigns helped to promote the necessity of confronting this phenomenon. More importantly, they laid the foundations of the birth control policies that currently take place in China.

  13. Photographic observations of major planets and their moons in MAO NAS of Ukraine during 1961-1990

    Science.gov (United States)

    Yizhakevych, O.; Andruk, V.; Pakuliak, L.; Lukianchuk, V.

    2017-06-01

    We present the results of digitizing and processing of archival observations to obtain the astrometric positions and stellar magnitudes of major planets and their satellites. The work has been done within the framework of the national project "Ukrainian Virtual Observatory" on the basis of photographic observations carried out in MAO NASU. The processing of digital images and the astrometric reduction of data was made in the software package created and developed in MAO for the reduction astrometric negatives. The catalogue includes data of Saturn's moons (S2-S9), obtained using 4 telescopes in 1961-1990. The stellar catalogue TYCHO2 was used as the reference. The internal positional accuracy is ˜ 0.09 - ˜ 0.25 arcsec.The same procedure is now applying for the processing of photographic observations of Neptune, Uranus, and their moons, obtained in MAO during the same period.

  14. Wettability and corrosion of alumina embedded nanocomposite MAO coating on nanocrystalline AZ31B magnesium alloy

    Energy Technology Data Exchange (ETDEWEB)

    Gheytani, M.; Aliofkhazraei, M., E-mail: maliofkh@gmail.com; Bagheri, H.R.; Masiha, H.R.; Rouhaghdam, A. Sabour

    2015-11-15

    In this paper, micro- and nanocrystalline AZ31B magnesium alloy were coated by micro-arc oxidation method. In order to fabricate nanocrystalline surface layer, surface mechanical attrition treatment was performed and nano-grains with average size of 5–10 nm were formed on the surface of the samples. Coating process was carried out at different conditions including two coating times and two types of electrolyte. Alumina nanoparticles were utilized as suspension in electrolyte to form nanocomposite coatings by micro-arc oxidation method. Potentiodynamic polarization, percentage of porosity, and wettability tests were performed to study various characteristics of the coated samples. The results of scanning electron microscope imply that samples coated in silicate-based electrolyte involve much lower surface porosity (∼25%). Besides, the results of wettability test indicated that the maximum surface tension with deionized water is for nanocrystalline sample. In this regard, the sample coated in silicate-based suspension was 4 times more hydrophilic than the microcrystalline sample. - Highlights: • MAO in phosphate electrolyte needs higher energy as compared to silicate electrolyte. • Less porosity and finer grain size on free surface of the silicate-based coatings. • Observed porosity from top surface of coating shows the effect of the final MAO sparks. • SMAT affects surface roughness and accelerates growth kinetics.

  15. Mao-to Prolongs the Survival of and Reduces TNF-α Expression in Mice with Viral Myocarditis

    Directory of Open Access Journals (Sweden)

    Zhu Shijie

    2010-01-01

    Full Text Available Goal of this study was to evaluate effects of Mao-to on development of myocarditis induced by encephalomyocarditis (EMC virus in mice. Mice were randomly divided into five groups. Group N included uninfected controls (n = 18, while group A, B and C underwent intraperitoneal injection of EMC virus. Group A was administered oral saline from day 0 to day 4. Group B was administered oral Mao-to (500 mg−1 kg−1 day−1 from day 0 to day 4. Group C was administered Mao-to from day 2 to day 6. Group D was administered Mao-to from day 5 to day 10. Treated mice were followed for survival rates during 2 weeks after infection. Body weight (BW and organ weights including heart (HW, lungs, thymus and spleen were examined on days 4, 6 and 14. Survival rate of group C (36.4% was significantly improved compared with group A, B or D (0% of each, P < 0.05. HW and HW/BW ratio in group C was significantly (P < 0.05 lower than those in group A, B or D. Viral titers of hearts were significantly different among groups A, B and C. Cardiac expression in tumor necrosis factor-α (TNF-α was significantly reduced in group C in comparison with group A, B or D on day 6 by immunohistochemical study. Administration of Mao-to starting on day 2 improves mortality resulting from viral myocarditis in mice with reduced expression of cardiac TNF-α. These findings suggest that timing of Mao-to is crucial for preventing cardiac damage in mice with viral myocarditis.

  16. Effects of different components of Mao Dongqing's total flavonoids and total saponins on transient ischemic attack (TIA) model of rats.

    Science.gov (United States)

    Miao, Ming-San; Peng, Meng-Fan; Ma, Rui-Juan; Bai, Ming; Liu, Bao-Song

    2018-03-01

    Objective: To study the effects of the different components of the total flavonoids and total saponins from Mao Dongqing's active site on the rats of TIA model, determine the optimal reactive components ratio of Mao Dongqing on the rats of TIA. Methods: TIA rat model was induced by tail vein injection of tert butyl alcohol, the blank group was injected with the same amount of physiological saline, then behavioral score wasevaluated. Determination the level of glutamic acid in serum, the activity of Na+-K+-ATP enzyme, CA ++ -ATP enzyme and Mg ++ -ATP enzyme in Brain tissue, observe the changes of hippocampus in brain tissue, the comprehensive weight method was used to evaluate the efficacy of each component finally. Results: The contents of total flavonoids and total saponins in the active part of Mao Dongqing can significantly improve the pathological changes of brain tissue in rats, improve the activity of Na + -K + -ATP enzyme, Ca ++ -ATP enzyme and Mg ++ -ATP enzyme in the brain of rats, and reduce the level of glutamic acid in serum. The most significant of the contents was the ratio of 10:6. The different proportions of total flavonoids and total saponins in the active part of Mao Dongqing all has a better effect on the rats with TIA, and the ratio of 10:6 is the best active component for preventing and controlling TIA.

  17. Observations in the Past of Solar System Bodies with MAO NANU Plate Archives

    Science.gov (United States)

    Sergeeva, T. P.; Golovnya, V. V.; Yizhakevych, E. M.; Shatokhina, S. V.; Sergeev, A. V.

    2006-04-01

    The plate archives of the Main Astronomical Observatory of the National Academy of Sciences of Ukraine contain more than 100,000 images of minor planets with magnitude up to 16.7m. About 10% of the minor planets, found on our archival plates, were discovered many years after taking the plates. So we can rediscover them by so called "observation in the past" and obtain their positions for improvement of the dynamical models of their motions. Other Solar System bodies for which we try to get "observation in the past" are the external planets satellites. The criteria for chosen objects, the search methods, identification and determination of positions are discussed. The first results of the asteroids and the external planet satellites search in MAO plate archives are presented.

  18. Chemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold.

    Science.gov (United States)

    Cruz-Monteagudo, Maykel; Borges, Fernanda; Cordeiro, M Natalia D S; Helguera, Aliuska Morales; Tejera, Eduardo; Paz-Y-Mino, Cesar; Sanchez-Rodriguez, Aminael; Perera-Sardina, Yunier; Perez-Castillo, Yunierkis

    2017-11-14

    In the context of the current drug discovery efforts to find disease modifying therapies for Parkinson's disease (PD) the current single target strategy has proved inefficient. Consequently, the search for multi-potent agents is attracting more and more attention due to the multiple pathogenetic factors implicated in PD. Multiple evidences points to the dual inhibition of the monoamine oxidase B (MAO-B), as well as adenosine A2A receptor (A2AAR) blockade, as a promising approach to prevent the neurodegeneration involved in PD. Currently, only two chemical scaffolds has been proposed as potential dual MAO-B inhibitors/A2AAR antagonists (caffeine derivatives and benzothiazinones). In this study, we conduct a series of chemoinformatics analysis in order to evaluate and advance the potential of the chromone nucleus as a MAO-B/A2AAR dual binding scaffold. The information provided by SAR data mining analysis based on network similarity graphs and molecular docking studies support the suitability of the chromone nucleus as a potential MAOB/ A2AAR dual binding scaffold. Additionally, a virtual screening tool based on a group fusion similarity search approach was developed for the prioritization of potential MAO-B/A2AAR dual binder candidates. Among several data fusion schemes evaluated, the MEAN-SIM and MIN-RANK GFSS approaches demonstrated to be efficient virtual screening tools. Then, a combinatorial library potentially enriched with MAO-B/A2AAR dual binding chromone derivatives was assembled and sorted by using the MIN-RANK and then the MEAN-SIM GFSS VS approaches. The information and tools provided in this work represent valuable decision making elements in the search of novel chromone derivatives with a favorable dual binding profile as MAOB inhibitors and A2AAR antagonists with the potential to act as a disease-modifying therapeutic for Parkinson's disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  19. Corrosion behavior and mechanism of MAO coated Ti{sub 6}Al{sub 4}V with a grain-fined surface layer

    Energy Technology Data Exchange (ETDEWEB)

    Gu, Yanhong, E-mail: gu_yanhong@163.com [School of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China); Chen, Lingling, E-mail: daisy_chenlingling@163.com [School of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China); College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029 (China); Yue, Wen, E-mail: yw@cugb.edu.cn [School of Engineering and Technology, China University of Geosciences, Beijing 100083 (China); Chen, Ping, E-mail: chenp@ustb.edu.cn [School of Mechanical Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Chen, Fei, E-mail: chenfei@bipt.edu.cn [School of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China); Ning, Chengyun, E-mail: imcyning@scut.edu.cn [College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640 (China)

    2016-04-15

    In order to enhance the corrosion behavior of Ti{sub 6}Al{sub 4}V, a MAO coating was prepared on the surface refined by ultrasonic cold forging technology (UCFT). The surface roughness value and the grain were evaluated by atomic force microscope (AFM) and transmission electron microscope (TEM). The microstructure and phase component of the coated samples were analyzed by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The corrosion behavior of all the samples was examined by potentiodynamic polarization and electrode impedance spectroscopy (EIS) tests in a 3.5% NaCl solution. The results show that UCFT can reduce the surface roughness value and refine the grains. The micro-pore size of the UCFT-MAO sample is smaller and the pore number is less than those of MAO sample. The thickness of the coated sample is about 10 μm. The UCFT-MAO sample possesses the highest micro-hardness among all the samples. The UCFT-MAO sample has the best corrosion resistance with the lowest corrosion current density and the highest electrochemical impedance, which is attributed to UCFT pretreatment prior to MAO process on titanium alloys. The influence of UCFT on the corrosion process and corrosion mechanism were discussed. - Highlights: • UCFT was used to refine the grain before MAO coatings were prepared on Ti alloys. • UCFT treated Ti alloys have decreased surface roughness and refined grain. • Surface performance of MAO coatings on UCFT treated Ti alloys has been improved. • The influence of UCFT on the corrosion behavior and mechanism of MAO coatings was discussed.

  20. Pharmacology of Rasagiline, a New MAO-B Inhibitor Drug for the Treatment of Parkinson’s Disease with Neuroprotective Potential

    Directory of Open Access Journals (Sweden)

    John P.M. Finberg

    2010-07-01

    Full Text Available Rasagiline (Azilect is a highly selective and potent propargylamine inhibitor of monoamine oxidase (MAO type B. Like other similar propargylamine inhibitors, rasagiline binds covalently to the N5 nitrogen of the flavin residue of MAO, resulting in irreversible inactivation of the enzyme. Therapeutic doses of the drug which inhibit brain MAO-B by 95% or more cause minimal inhibition of MAO-A, and do not potentiate the pressor or other pharmacological effects of tyramine. Metabolic conversion of the compound in vivo is by hepatic cytochrome P450-1A2, with generation of 1-aminoindan as the major metabolite. Rasagiline possesses no amphetamine-like properties, by contrast with the related compound selegiline (Deprenyl, Jumex, Eldepryl. Although the exact distribution of MAO isoforms in different neurons and tissues is not known, dopamine behaves largely as a MAO-A substrate in vivo, but following loss of dopaminergic axonal varicosities from the striatum, metabolism by glial MAO-B becomes increasingly important. Following subchronic administration to normal rats, rasagiline increases levels of dopamine in striatal microdialysate, possibly by the build-up of β-phenylethylamine, which is an excellent substrate for MAO-B, and is an effective inhibitor of the plasma membrane dopamine transporter (DAT. Both of these mechanisms may participate in the anti-Parkinsonian effect of rasagiline in humans. Rasagiline possesses neuroprotective properties in a variety of primary neuronal preparations and neuron-like cell lines, which is not due to MAO inhibition. Recent clinical studies have also demonstrated possible neuroprotective properties of the drug in human Parkinsonian patients, as shown by a reduced rate of decline of symptoms over time.

  1. A combined quantum mechanical and statistical mechanical study of the equilibrium of trimethylaluminum (TMA) and oligomers of (AlOCH(3))(n) found in methylaluminoxane (MAO) solution.

    Science.gov (United States)

    Zurek, E; Ziegler, T

    2001-07-02

    Density Functional Theory (DFT) has been used to calculate the energies of over 30 different structures with the general formula (AlOMe)(n).(AlMe(3))(m) where n ranges from 6 to 13 and m ranges between 1 and 4, depending upon the structure of the parent (AlOMe)(n) cage. The way in which TMA (trimethylaluminum) bonds to MAO (methylaluminoxane) has been determined as well as the location of the acidic sites present in MAO caged structures. Topological arguments have been used to show that TMA does not bind to MAO cages where n = 12 or n > or = 14. The ADF energies in conjunction with frequency calculations based on molecular mechanics have been used to estimate the finite temperature enthalpies, entropies, and free energies of the TMA containing MAO structures. Using the Gibbs free energies found for pure MAO structures calculated in a previous work, in conjunction with the free energies of TMA containing MAO structures obtained in the present study, it was possible to determine the percent abundance of each TMA containing MAO within the temperature range of 198.15 K-598.15 K. We have found that very little TMA is actually bound to MAO. The Me/Al ratio on the MAO cages is determined as being approximately 1.00, 1.01, 1.02, and 1.03 at 198, 298, 398, and 598 K, respectively. Moreover, the percentage of Al found as TMA has been calculated as being 0.21%, 0.62%, 1.05%, and 1.76% and the average unit formulas of (AlOMe)(18.08).(TMA)(0.04), (AlOMe)(17.04).(TMA)(0.11), (AlOMe)(15.72).(TMA)(0.17), and (AlOMe)(14.62).(TMA)(0.26) have been determined at the aforementioned temperatures.

  2. STYRENE/STYRENE-DERIVATIVE COPOLYMERIZATION BY PH2Zn-METALLOCENE-MAO SYSTEMS: HOMO- AND COPOLYMERIZATION OF á-METHYLSTYRENE WITH STYRENE

    OpenAIRE

    RABAGLIATI, FRANCO M; MUÑOZ, HÉCTOR E; MARDONES, GABRIELA V

    2010-01-01

    The copolymerization of styrene with á-methylstyrene has been tested using combined metallocene-MAO initiator systems with and without diphenylzinc. The metallocenes used were biscyclopentadienyltitanium dichloride, Cp2TiCl2, bis(n-butylcyclopentadienyl)titanium dichloride, (n-BuCp)2TiCl2, and the half-sandwich metallocene indenyltitanium trichloride, IndTiCl3. The results indicate that both binary metallocene-MAO, and ternary Ph2Zn-metallocene-MAO systems are capable of polymerizing á-methyl...

  3. Electrochemical corrosion behavior of composite MAO/sol-gel coatings on magnesium alloy AZ91D using combined micro-arc oxidation and sol-gel technique

    International Nuclear Information System (INIS)

    Shang Wei; Chen Baizhen; Shi Xichang; Chen Ya; Xiao Xiang

    2009-01-01

    Protective composite coatings were obtained on a magnesium alloy by micro-arc oxidation (MAO) and sol-gel technique. The coatings consisted of a MAO layer and a sol-gel layer. The microstructure and composition of the MAO coating and the composite coatings were analyzed by scanning electron microscopy (SEM) and energy dispersive X-rays (EDX). Potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and total immersion tests were used to evaluate the corrosion behavior of these coatings in a 3.5 wt.% NaCl solution. The results show that the sol-gel layer provides corrosion protection by physically sealing the pores in the MAO coating and acting as a barrier. The composite coatings can suppress the corrosion process by preventing the corrosive ions from transferring or diffusing to the magnesium alloy substrate. This enhances the corrosion resistance of the magnesium alloy AZ91D significantly

  4. Improved sensitivity of human brain MAO B measurement using deuterium substituted [{sup 11}C]L-deprenyl ([{sup 11}C]L-deprenyl-D2)

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, J.S.; Volkow, N.D.; Wang, G.J. [Brookhaven National Laboratory, Upton, NY (United States)] [and others

    1995-05-01

    Post-mortem reports that human brain monoamine oxidase B (MAO B) increases in normal aging and neurodegenerative disorders due to the proliferation of MAO B-rich glial cells suggest that PET measures of MAO B may track gliosis. We have recently shown that the MAO B tracer [{sup 11}C]L-deprenyl has limited sensitivity in regions of high MAO B due to its rapid rate of trapping. This limits its utility for measuring MAO B in brain regions where MAO B is higher and/or where blood flow is low. We have recently demonstrated that [{sup 11}C]L-deprenyl-D2 has improved sensitivity in regions of high MAO B due to the deuterium isotope effect which reduces the rate of trapping. We report studies [{sup 11}C]L-deprenyl-D2 in normal human brain in 16 healthy men and women (age range 23-73) to assess tracer sensitivity, regional distribution, and reproducibility. Graphical analysis for irreversible systems was used to calculate Ki (influx constant) as an index of MAO B concentration in different brain regions. The uptake of carbon-11 in different brain regions was rapid, peaking at 5 minutes and plateauing from 30-60 minutes after an initial clearance. MAO B was highest in subcortical regions: thalamus{ge}basal ganglia>cingulate gyrus>frontal cortex=occipital cortex=cerebellum in agreement with post-mortem measurements. Ki values were highly correlated within an individual. Repeated measures at 1-4 week intervals were highly correlated (r=0.9; p=0.0001). In women (n=8: age range 23-73), Ki increased with increasing age for 8 brain regions (p < 0.04). Though men (N=8; age range 34-70) showed no correlation with age, a larger sample size is needed to adequately assess trends. In summary, the use of [{sup 11}C]L-deprenyl-D2 improves the measurement of MAO B in the human brain permitting its investigation as a positive tracer for glial cell proliferation in neurodegenerative disorders.

  5. Fabrication and characterization of rod-like nano-hydroxyapatite on MAO coating supported on Mg-Zn-Ca alloy

    Science.gov (United States)

    Gao, J. H.; Guan, S. K.; Chen, J.; Wang, L. G.; Zhu, S. J.; Hu, J. H.; Ren, Z. W.

    2011-01-01

    The poor corrosion resistance of magnesium alloys is a dominant problem that limits their clinical application. In order to solve this challenge, micro-arc oxidation (MAO) was used to fabricate a porous coating on magnesium alloys and then electrochemical deposition (ED) was done to fabricate rod-like nano-hydroxyapatite (RNHA) on MAO coating. The cross-section morphology of the composite coatings and its corresponding energy dispersion spectroscopy (EDS) surficial scanning map of calcium revealed that HA rods were successfully deposited into the pores. The three dimensional morphology and scanning electron microscopy (SEM) image of the composite coatings showed that the distribution of the HA rods was dense and uniform. Atomic force microscope (AFM) observation of the composite coatings showed that the diameters of HA rods varied from 95 nm to 116 nm and the root mean square roughness (RMS) of the composite coatings was about 42 nm, which were favorable for cellular survival. The bonding strength between the HA film and MAO coating increased to 12.3 MPa, almost two times higher than that of the direct electrochemical deposition coating (6.3 MPa). Compared with that of the substrate, the corrosion potential of Mg-Zn-Ca alloy with composite coatings increased by 161 mV and its corrosion current density decreased from 3.36 × 10 -4 A/cm 2 to 2.40 × 10 -7 A/cm 2 which was due to the enhancement of bonding strength and the deposition of RNHA in the MAO pores. Immersion tests were carried out at 36.5 ± 0.5 °C in simulated body fluid (SBF). It was found that RNHA can induce the rapid precipitation of calcium orthophosphates in comparison with conventional HA coatings. Thus magnesium alloy coated with the composite coatings is a promising candidate as biodegradable bone implants.

  6. Fabrication and characterization of rod-like nano-hydroxyapatite on MAO coating supported on Mg-Zn-Ca alloy

    International Nuclear Information System (INIS)

    Gao, J.H.; Guan, S.K.; Chen, J.; Wang, L.G.; Zhu, S.J.; Hu, J.H.; Ren, Z.W.

    2011-01-01

    The poor corrosion resistance of magnesium alloys is a dominant problem that limits their clinical application. In order to solve this challenge, micro-arc oxidation (MAO) was used to fabricate a porous coating on magnesium alloys and then electrochemical deposition (ED) was done to fabricate rod-like nano-hydroxyapatite (RNHA) on MAO coating. The cross-section morphology of the composite coatings and its corresponding energy dispersion spectroscopy (EDS) surficial scanning map of calcium revealed that HA rods were successfully deposited into the pores. The three dimensional morphology and scanning electron microscopy (SEM) image of the composite coatings showed that the distribution of the HA rods was dense and uniform. Atomic force microscope (AFM) observation of the composite coatings showed that the diameters of HA rods varied from 95 nm to 116 nm and the root mean square roughness (RMS) of the composite coatings was about 42 nm, which were favorable for cellular survival. The bonding strength between the HA film and MAO coating increased to 12.3 MPa, almost two times higher than that of the direct electrochemical deposition coating (6.3 MPa). Compared with that of the substrate, the corrosion potential of Mg-Zn-Ca alloy with composite coatings increased by 161 mV and its corrosion current density decreased from 3.36 x 10 -4 A/cm 2 to 2.40 x 10 -7 A/cm 2 which was due to the enhancement of bonding strength and the deposition of RNHA in the MAO pores. Immersion tests were carried out at 36.5 ± 0.5 deg. C in simulated body fluid (SBF). It was found that RNHA can induce the rapid precipitation of calcium orthophosphates in comparison with conventional HA coatings. Thus magnesium alloy coated with the composite coatings is a promising candidate as biodegradable bone implants.

  7. Fabrication and characterization of rod-like nano-hydroxyapatite on MAO coating supported on Mg-Zn-Ca alloy

    Energy Technology Data Exchange (ETDEWEB)

    Gao, J.H. [Materials Research Center, School of Materials Science and Engineering, Zhengzhou University, Zhenzhou 450002 (China); Guan, S.K., E-mail: skguan@zzu.edu.cn [Materials Research Center, School of Materials Science and Engineering, Zhengzhou University, Zhenzhou 450002 (China); Chen, J. [Materials Research Center, School of Materials Science and Engineering, Zhengzhou University, Zhenzhou 450002 (China); Division of Materials and Manufacturing Science, Osaka University, Osaka 567-0047 (Japan); Wang, L.G.; Zhu, S.J.; Hu, J.H.; Ren, Z.W. [Materials Research Center, School of Materials Science and Engineering, Zhengzhou University, Zhenzhou 450002 (China)

    2011-01-01

    The poor corrosion resistance of magnesium alloys is a dominant problem that limits their clinical application. In order to solve this challenge, micro-arc oxidation (MAO) was used to fabricate a porous coating on magnesium alloys and then electrochemical deposition (ED) was done to fabricate rod-like nano-hydroxyapatite (RNHA) on MAO coating. The cross-section morphology of the composite coatings and its corresponding energy dispersion spectroscopy (EDS) surficial scanning map of calcium revealed that HA rods were successfully deposited into the pores. The three dimensional morphology and scanning electron microscopy (SEM) image of the composite coatings showed that the distribution of the HA rods was dense and uniform. Atomic force microscope (AFM) observation of the composite coatings showed that the diameters of HA rods varied from 95 nm to 116 nm and the root mean square roughness (RMS) of the composite coatings was about 42 nm, which were favorable for cellular survival. The bonding strength between the HA film and MAO coating increased to 12.3 MPa, almost two times higher than that of the direct electrochemical deposition coating (6.3 MPa). Compared with that of the substrate, the corrosion potential of Mg-Zn-Ca alloy with composite coatings increased by 161 mV and its corrosion current density decreased from 3.36 x 10{sup -4} A/cm{sup 2} to 2.40 x 10{sup -7} A/cm{sup 2} which was due to the enhancement of bonding strength and the deposition of RNHA in the MAO pores. Immersion tests were carried out at 36.5 {+-} 0.5 deg. C in simulated body fluid (SBF). It was found that RNHA can induce the rapid precipitation of calcium orthophosphates in comparison with conventional HA coatings. Thus magnesium alloy coated with the composite coatings is a promising candidate as biodegradable bone implants.

  8. Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer's disease and elderly controls after oral administration of sembragiline

    International Nuclear Information System (INIS)

    Sturm, Stefan; Forsberg, Anton; Stenkrona, Per; Varrone, Andrea; Fazio, Patrik; Nakao, Ryuji; Halldin, Christer; Nave, Stephane; Jamois, Candice; Ricci, Benedicte; Seneca, Nicholas; Comley, Robert A.; Ejduk, Zbigniew; Al-Tawil, Nabil; Akenine, Ulrika; Andreasen, Niels

    2017-01-01

    In Alzheimer's disease (AD), increased metabolism of monoamines by monoamine oxidase type B (MAO-B) leads to the production of toxic reactive oxygen species (ROS), which are thought to contribute to disease pathogenesis. Inhibition of the MAO-B enzyme may restore brain levels of monoaminergic neurotransmitters, reduce the formation of toxic ROS and reduce neuroinflammation (reactive astrocytosis), potentially leading to neuroprotection. Sembragiline (also referred as RO4602522, RG1577 and EVT 302 in previous communications) is a potent, selective and reversible inhibitor of MAO-B developed as a potential treatment for AD. This study assessed the relationship between plasma concentration of sembragiline and brain MAO-B inhibition in patients with AD and in healthy elderly control (EC) subjects. Positron emission tomography (PET) scans using [ 11 C]- L -deprenyl-D 2 radiotracer were performed in ten patients with AD and six EC subjects, who received sembragiline each day for 6-15 days. At steady state, the relationship between sembragiline plasma concentration and MAO-B inhibition resulted in an E max of ∝80-90 % across brain regions of interest and in an EC 50 of 1-2 ng/mL. Data in patients with AD and EC subjects showed that near-maximal inhibition of brain MAO-B was achieved with 1 mg sembragiline daily, regardless of the population, whereas lower doses resulted in lower and variable brain MAO-B inhibition. This PET study confirmed that daily treatment of at least 1 mg sembragiline resulted in near-maximal inhibition of brain MAO-B enzyme in patients with AD. (orig.)

  9. Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer's disease and elderly controls after oral administration of sembragiline

    Energy Technology Data Exchange (ETDEWEB)

    Sturm, Stefan [Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel (Switzerland); F. Hoffmann-La Roche Ltd, Basel (Switzerland); Forsberg, Anton; Stenkrona, Per; Varrone, Andrea; Fazio, Patrik; Nakao, Ryuji; Halldin, Christer [Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatric Research, Stockholm (Sweden); Nave, Stephane; Jamois, Candice; Ricci, Benedicte [Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel (Switzerland); Seneca, Nicholas [AstraZeneca Translational Science Center, Stockholm (Sweden); Comley, Robert A. [AbbVie, North Chicago, IL (United States); Ejduk, Zbigniew [Miedzyleski Specialistic Hospital, Internal Disease and Gastroenterology, Warsaw (Poland); Al-Tawil, Nabil [Karolinska University Hospital, Karolinska Trial Alliance Phase 1 Unit, Stockholm (Sweden); Akenine, Ulrika; Andreasen, Niels [Karolinska University Hospital, Karolinska Institutet Alzheimer Disease Research Centre and Clinical Trial Unit, Geriatric Clinic, Huddinge (Sweden)

    2017-03-15

    In Alzheimer's disease (AD), increased metabolism of monoamines by monoamine oxidase type B (MAO-B) leads to the production of toxic reactive oxygen species (ROS), which are thought to contribute to disease pathogenesis. Inhibition of the MAO-B enzyme may restore brain levels of monoaminergic neurotransmitters, reduce the formation of toxic ROS and reduce neuroinflammation (reactive astrocytosis), potentially leading to neuroprotection. Sembragiline (also referred as RO4602522, RG1577 and EVT 302 in previous communications) is a potent, selective and reversible inhibitor of MAO-B developed as a potential treatment for AD. This study assessed the relationship between plasma concentration of sembragiline and brain MAO-B inhibition in patients with AD and in healthy elderly control (EC) subjects. Positron emission tomography (PET) scans using [{sup 11}C]-{sub L}-deprenyl-D{sub 2} radiotracer were performed in ten patients with AD and six EC subjects, who received sembragiline each day for 6-15 days. At steady state, the relationship between sembragiline plasma concentration and MAO-B inhibition resulted in an E{sub max} of ∝80-90 % across brain regions of interest and in an EC{sub 50} of 1-2 ng/mL. Data in patients with AD and EC subjects showed that near-maximal inhibition of brain MAO-B was achieved with 1 mg sembragiline daily, regardless of the population, whereas lower doses resulted in lower and variable brain MAO-B inhibition. This PET study confirmed that daily treatment of at least 1 mg sembragiline resulted in near-maximal inhibition of brain MAO-B enzyme in patients with AD. (orig.)

  10. Landslide Hazard Zonation Along NH-39 From Kangpokpi To Mao, Manipur, India

    Directory of Open Access Journals (Sweden)

    TH. DEVALA DEVI

    2011-06-01

    Full Text Available Due to the prevailing high rainfall and complex nature of terrain, hilly areas of Manipur are vulnerable to instability and mass wasting which have been aggravated by rapid pace of anthropogenic activities and high seismicity. To categorize the land surface into areas and arrange them according to degree of actual or potential hazard from landslide or other mass movements on slopes, an effort is made to prepare landslide hazard zonation map along NH-39 from Kangpokpi to Mao, covering an area of 650km2. Based on the hazardousness to landslide the study area has been divided into four different zones. The major part of the study area about 380km2 (58% falls under the category of high risk zone, followed by moderate risk zone covering an area of 152km2, low risk zone (115 km2, and very high hazard zone (3 km2. Such zonation maps are useful for identifying and delineating unstable hazard prone areas so that suitable mitigative measures can be adopted to minimize the hazards. It also helps planners to choose the favorable sites for developmental schemes like road and building constructions.

  11. Corrosion performance of MAO coatings on AZ31 Mg alloy in simulated body fluid vs. Earle's Balance Salt Solution

    Energy Technology Data Exchange (ETDEWEB)

    Wilke, Benjamin M. [Department of Mechanical Engineering, PO Box 755905, University of Alaska Fairbanks, Fairbanks, AK 99775 (United States); Zhang, Lei, E-mail: lzhang14@alaska.edu [Department of Mechanical Engineering, PO Box 755905, University of Alaska Fairbanks, Fairbanks, AK 99775 (United States); Li, Weiping; Ning, Chengyun [School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China); Chen, Cheng-fu [Department of Mechanical Engineering, PO Box 755905, University of Alaska Fairbanks, Fairbanks, AK 99775 (United States); Gu, Yanhong [College of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China)

    2016-02-15

    Graphical abstract: - Highlights: • MAO coating is deposited on AZ31 Mg alloy by microarc oxidation. • Corrosion performance of MAO-coated AZ31 in EBSS vs. c-SBF is studied. • MAO-coated AZ31 exhibits enhanced corrosion resistance compared to bare AZ31. • Samples in EBSS show slower corrosion progression than the samples in c-SBF. • CO{sub 2} buffer and less chloride in EBSS cause corrosion rate gap in c-SBF and EBSS. - Abstract: Earle's Balance Salt Solution (EBSS) provides an alternative to the conventional simulated body fluids (c-SBF) and has been shown to better simulate the corrosion conditions in vivo. In this work, a series of tests were conducted to explore the corrosion performance of MAO-coated AZ31 samples in EBSS vs. c-SBF. Samples were produced by varying MAO process parameters and then immersed up to 21 days in both EBSS and c-SBF. The corrosion rates were evaluated by the electrochemical impedance spectroscopy and potentiodynamic scanning. Scanning electron microscope (SEM) was used to compare the progression of microcracks across the surface of the coatings. The evaluation of cross-sectional thickness showed an increase in MAO coating thickness with the process voltage. MAO samples with a thicker coating generally have higher impedance and lower current density at the initial immersion time point of 0.5 h. Samples in EBSS showed higher initial impedance and lower current density values as compared to c-SBF counterparts for all process groups. Samples in EBSS demonstrated a much slower corrosion rate than c-SBF samples because of the decreased chloride content and CO{sub 2} buffering mechanism of the EBSS.

  12. 5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO).

    Science.gov (United States)

    Herraiz, Tomás; Brandt, Simon D

    2014-01-01

    5-(2-Aminopropyl)indole (5-IT) is a psychoactive compound that has recently been associated with several fatal and non-fatal intoxications in a number of European countries. There are indications that acute effects may include symptoms of monoaminergic (e.g. serotonin) toxicity and one mechanism involved in the increase of serotonin levels includes the inhibition of monoamine oxidase. This study investigated the effect of 5-IT on human MAO-A and -B isozymes using kynuramine as the substrate. Substrate conversion to 4-hydroxyquinoline was monitored by high-performance liquid chromatography coupled to diode array detection. This method was employed to determine the extent of MAO inhibition (IC50 and Ki ) and it was found that 5-IT was a selective, competitive and reversible inhibitor of MAO-A. 5-IT revealed a relatively potent ability to inhibit MAO-A (IC50  =1.6 μM and Ki  =0.25 μM) while MAO-B inhibition was not observed (0-500 μM 5-IT). Under identical experimental conditions, other established inhibitors of MAO-A and antidepressants provided the following IC50 values: clorgyline 16 nM, harmaline 20 nM, toloxatone 6.7 μM and moclobemide >500 μM. These data indicated that 5-IT was less potent than clorgyline and harmaline but more potent than toloxatone and moclobemide under the in-vitro conditions studied. The inhibition of MAO-A suggests that 5-IT by itself or in combination with other substances may be able to potentiate serotonergic/monoaminergic effects and further studies are needed to clarify its relevance to the adverse effects reported for 5-IT. Copyright © 2013 John Wiley & Sons, Ltd.

  13. Corrosion performance of MAO coatings on AZ31 Mg alloy in simulated body fluid vs. Earle's Balance Salt Solution

    International Nuclear Information System (INIS)

    Wilke, Benjamin M.; Zhang, Lei; Li, Weiping; Ning, Chengyun; Chen, Cheng-fu; Gu, Yanhong

    2016-01-01

    Graphical abstract: - Highlights: • MAO coating is deposited on AZ31 Mg alloy by microarc oxidation. • Corrosion performance of MAO-coated AZ31 in EBSS vs. c-SBF is studied. • MAO-coated AZ31 exhibits enhanced corrosion resistance compared to bare AZ31. • Samples in EBSS show slower corrosion progression than the samples in c-SBF. • CO 2 buffer and less chloride in EBSS cause corrosion rate gap in c-SBF and EBSS. - Abstract: Earle's Balance Salt Solution (EBSS) provides an alternative to the conventional simulated body fluids (c-SBF) and has been shown to better simulate the corrosion conditions in vivo. In this work, a series of tests were conducted to explore the corrosion performance of MAO-coated AZ31 samples in EBSS vs. c-SBF. Samples were produced by varying MAO process parameters and then immersed up to 21 days in both EBSS and c-SBF. The corrosion rates were evaluated by the electrochemical impedance spectroscopy and potentiodynamic scanning. Scanning electron microscope (SEM) was used to compare the progression of microcracks across the surface of the coatings. The evaluation of cross-sectional thickness showed an increase in MAO coating thickness with the process voltage. MAO samples with a thicker coating generally have higher impedance and lower current density at the initial immersion time point of 0.5 h. Samples in EBSS showed higher initial impedance and lower current density values as compared to c-SBF counterparts for all process groups. Samples in EBSS demonstrated a much slower corrosion rate than c-SBF samples because of the decreased chloride content and CO 2 buffering mechanism of the EBSS.

  14. Structural characterization of MAO and related aluminum complexes. 1. Solid-state (27)Al NMR with comparison to EFG tensors from ab initio molecular orbital calculations.

    Science.gov (United States)

    Bryant, P L; Harwell, C R; Mrse, A A; Emery, E F; Gan, Z; Caldwell, T; Reyes, A P; Kuhns, P; Hoyt, D W; Simeral, L S; Hall, R W; Butler, L G

    2001-12-05

    Experimental and ab initio molecular orbital techniques are developed for study of aluminum species with large quadrupole coupling constants to test structural models for methylaluminoxanes (MAO). The techniques are applied to nitrogen- and oxygen-containing complexes of aluminum and to solid MAO isolated from active commercial MAO preparations. (Aminato)- and (propanolato)aluminum clusters with 3-, 4-, and 6-coordinate aluminum sites are studied with three (27)Al NMR techniques optimized for large (27)Al quadrupole coupling constants: field-swept, frequency-stepped, and high-field MAS NMR. Four-membered (aminato)aluminum complexes with AlN(4) coordination yield slightly smaller C(q) values than similar AlN(2)C(2) sites: 12.2 vs 15.8 MHz. Planar 3-coordinate AlN(2)C sites have the largest C(q) values, 37 MHz. In all cases, molecular orbital calculations of the electric field gradient tensors yields C(q) and eta values that match with experiment, even for a large hexameric (aminato)aluminum cage. A D(3d) symmetry hexaaluminum oxane cluster, postulated as a model for MAO, yields a calculated C(q) of -23.7 MHz, eta = 0.7474, and predicts a spectrum that is too broad to match the field-swept NMR of methylaluminoxane, which shows at least three sites, all with C(q) values greater than 15 MHz but less than 21 MHz. Thus, the proposed hexaaluminum cluster, with its strained four-membered rings, is not a major component of MAO. However, calculations for dimers of the cage complex, either edge-bridged or face-bridged, show a much closer match to experiment. Also, MAO preparations differ, with a gel form of MAO having significantly larger (27)Al C(q) values than a nongel form, a conclusion reached on the basis of (27)Al NMR line widths in field-swept NMR spectra acquired from 13 to 24 T.

  15. 123I-labeling and evaluation of Ro 43-0463, a SPET tracer for MAO-B imaging

    International Nuclear Information System (INIS)

    Beer, H.-F.; Rossetti, I.; Frey, L.D.; Hasler, P.H.; Schubiger, P.A.

    1995-01-01

    Using the copper assisted halogen exchange the MAO-B inhibitor Ro 43-0463, N-(2-aminoethyl)-5-iodo-2-pyridinecarboxamide, was labelled with 123 I as well as with 125 I to allow in vitro and in vivo investigations including SPET with healthy volunteers. Ro 43-0463 is known to inhibit reversibly and specifically MAO-B, having an ic 50 of 3 x 10 -8 Mol/L. The labeling in the presence of CuSO 4 and ascorbic acid was optimised, varying time (30 to 105 min), precursor concentration (1-3.5 mg) and temperature (130-200 deg. C). The labeling yield ranged between 60 and 70%. Purification was achieved with Lichrosorb RP-18 (5 μm, 250 x 8 mm) and 1.5 mL/min 0.36 M H 3 PO 4 /EtOH (97(3)) [0.01 M (NH 4 ) 2 HPO 4 ]. After neutralisation and sterile filtration the final activity concentration ranged between 18.5 and 37 MBq/mL. Biodistribution studies showed a brain to blood ratio greater than 1 within 1 h p.i. The main radiation burden calculated from these animal data is to alimentary and excretory organs and the ovaries. Autoradiography was performed using rat brain slices and 5 nM [ 125 I]Ro 43-0463 in TRIS-buffer pH 7.4 for 90 min at 20 deg. C. Its radioactivity pattern corresponds to the known distribution of MAO-B in the rat brain. By displacement with L-deprenyl the highly specific binding of Ro 43-0463 was proven in vitro. SPECT studies with normal volunteers corresponded with the pattern found in autoradiography

  16. Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl.

    Science.gov (United States)

    Schulz, Daniela; Mirrione, Martine M; Henn, Fritz A

    2010-02-01

    Cognitive processes are assumed to change with learned helplessness, an animal model of depression, but little is known about such deficits. Here we investigated the role of cognitive and related functions in selectively bred helpless (cLH, n=10), non-helpless (cNLH, n=12) and wild type (WT, n=8) Sprague Dawley rats. The animals were exposed to an open field for 10min on each of two test days. On the third day, an object exploration paradigm was carried out. The animals were later tested for helplessness. Both cLH and cNLH rats were more active than WTs on the first day in the open field. Over trials, cNLH and WT rats lowered their activity less than cLH rats. This resistance-to-habituation co-varied with a resistance to develop helplessness. In cLH rats, higher 'anxiety' or less time spent in the center of the open field co-varied with severe helplessness. In WTs, a greater reactivity to novel objects and to a spatially relocated object predicted lower levels of helplessness. In cLH rats (n=4-5 per group), chronic treatment with a high dose of the monoamine oxidase (MAO)-B inhibitor deprenyl (10mg/kg; i.p.), an anti-Parkinson, nootropic and antidepressant drug, attenuated helplessness. Remarkably, helplessness reversal required the experience of repeated test trials, reminiscent of a learning process. Chronic deprenyl (10mg/kg; i.p.) did not alter locomotion/exploration or 'anxiety' in the open field. In conclusion, helplessness may be related to altered mechanisms of reinforcement learning and working memory, and to abnormalities in MAO-A and/or MAO-B functioning. Copyright 2009 Elsevier Inc. All rights reserved.

  17. Inhibition potential of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites on the in vitro monoamine oxidase (MAO)-catalyzed deamination of the neurotransmitters serotonin and dopamine.

    Science.gov (United States)

    Steuer, Andrea E; Boxler, Martina I; Stock, Lorena; Kraemer, Thomas

    2016-01-22

    Neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) is still controversially discussed. Formation of reactive oxygen species e.g. based on elevated dopamine (DA) concentrations and DA quinone formation is discussed among others. Inhibition potential of MDMA metabolites regarding neurotransmitter degradation by catechol-O-methyltransferase and sulfotransferase was described previously. Their influence on monoamine oxidase (MAO) - the major DA degradation pathway-has not yet been studied in humans. Therefore the inhibition potential of MDMA and its metabolites on the deamination of the neurotransmitters DA and serotonin (5-HT) by MAO-A and B using recombinant human enzymes in vitro should be investigated. In initial studies, MDMA and MDA showed relevant inhibition (>30%) toward MAO A for 5-HT and DA. No relevant effects toward MAO B were observed. Further investigation on MAO-A revealed MDMA as a competitive inhibitor of 5-HT and DA deamination with Ki 24.5±7.1 μM and 18.6±4.3 μM respectively and MDA as a mixed-type inhibitor with Ki 7.8±2.6 μM and 8.4±3.2 μM respectively. Although prediction of in vivo relevance needs to be done with care, relevant inhibitory effects at expected plasma concentrations after recreational MDMA consumption seems unlikely based on the obtained data. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  18. Catalog of Astronomical Positions of Saturn's Moons Obtained by Photographic Observations at the Mao Nasu in 1961-1991

    Science.gov (United States)

    Yizhakevych, O. M.; Andruk, V. M.; Pakuliak, L. K.

    In the framework of UkrVO national project the new methods of plate digital image processing are developed. The photographic material of the UkrVO Joint Digital Archive (JDA, http://194.44.35.19/vo-mao/DB/ archivespecial.php) is used for the solution of classic astrometric problem - positional and photometric determinations of objects registered on the plates including Saturn's moons. The results of tested methods show that the positional RMS errors are better than ±150 mas for both coordinates and photometric ones are better than ±0.20m with the Tycho-2 catalogue as reference.

  19. Lesson Learning at JPL

    Science.gov (United States)

    Oberhettinger, David

    2011-01-01

    A lessons learned system is a hallmark of a mature engineering organization A formal lessons learned process can help assure that valuable lessons get written and published, that they are well-written, and that the essential information is "infused" into institutional practice. Requires high-level institutional commitment, and everyone's participation in gathering, disseminating, and using the lessons

  20. Dual functional cholinesterase and MAO inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of homoisoflavonoid derivatives.

    Science.gov (United States)

    Wang, Yali; Sun, Yang; Guo, Yueyan; Wang, Zechen; Huang, Ling; Li, Xingshu

    2016-01-01

    Because of the complexity of Alzheimer's disease (AD), the multi-target-directed ligand (MTDL) strategy is expected to provide superior effects for the treatment of AD, instead of the classic one-drug-one-target strategy. In this context, we focused on the design, synthesis and evaluation of homoisoflavonoid derivatives as dual acetyl cholinesterase (AChE) and monoamine oxidase (MAO-B) inhibitors. Among all the synthesized compounds, compound 10 provided a desired balance of AChE and hMAO-B inhibition activities, with IC50 value of 3.94 and 3.44 μM, respectively. Further studies revealed that compound 10 was a mixed-type inhibitor of AChE and an irreversible inhibitor of hMAO-B, which was also confirmed by molecular modeling studies. Taken together, the data indicated that 10 was a promising dual functional agent for the treatment of AD.

  1. Digital Archive of UkrVO: first results of MAO NASU Solar System Bodies photographic plate processing

    Science.gov (United States)

    Ivanov, G.; Pakuliak, L.; Shatokhina, S.; Yizhakevych, E.; Kazantseva, L.; Andruk, V.

    The digitizing and processing of photographic plates with the images of the outer planets and their satellites from the archive collections of MAO NASU and AO of Kiev university included into the UkrVO Joint Digital Archive (JDA) have been made. Plates were obtained in the last half of the 20th century. The digitizing of JDA archive plates and inclusion of plate preview images into GPA database has been under way, using two models of flatbed scanners: Microtek ScanMaker 9800XL TMA and Epson Expression 10000XL. The database with metadata of plates is allocated on the computational resources of MAO NASU (http://gua.db.ukr-vo.org). Plates have been scanned at 16-bits grey dynamic range, with a resolution of 1200-1600 dpi, and saved in TIFF format. Linear dimensions of images are up to 13 thousand pixels (for plates 30.30 cm). The astrometric and photometric calibration procedures have been done in the LINUX-MIDASROMAFOT environment and Tycho-2 as reference with the image processing procedure specially developed for digitized images of huge linear dimensions on the basis of the image inherent traits. First results of digitized plate processing give the rms errors of 10 and 20 mas for RA, DEC respectively. (O-C) for plates with Pluto in comparison to JPL PLU021.DE405 has been derived of 140(RA) and 270(DEC) mas.

  2. Evaluation of magnesium ions release, biocorrosion, and hemocompatibility of MAO/PLLA-modified magnesium alloy WE42.

    Science.gov (United States)

    Lu, Ping; Cao, Lu; Liu, Yin; Xu, Xinhua; Wu, Xiangfeng

    2011-01-01

    Magnesium alloys may potentially be applied as biodegradable metallic materials in cardiovascular stent. However, the high corrosion rate hinders its clinical application. In this study, a new approach was adopted to control the corrosion rate by fabricating a biocompatible micro-arc oxidation/poly-L-lactic acid (MAO/PLLA) composite coating on the magnesium alloy WE42 substrate and the biocompatibility of the modified samples was investigated. The scanning electronic microscope (SEM) images were used to demonstrate the morphology of the samples before and after being submerged in hanks solution for 4 weeks. The degradation was evaluated through the magnesium ions release rate and electrochemical impedance spectroscopy (EIS) test. The biocompatibility of the samples was demonstrated by coagulation time and hemolysis behavior. The result shows that the poly-L-lactic acid (PLLA) effectively improved the corrosion resistance by sealing the microcracks and microholes on the surface of the MAO coating. The modified samples had good compatibility. © 2010 Wiley Periodicals, Inc.

  3. BANGUNAN TINGGI MULTI FUNGSI SEBAGAI SINTESIS ARSITEKTUR DAN STRUKTUR Studi Analisis Jin Mao Tower Grand Hyatt Shanghai

    Directory of Open Access Journals (Sweden)

    Jimmy Priatman

    2005-01-01

    Full Text Available More than two decades, after the emerging of post- modern architecture, the split between construction technology and cultural expression in architecture appeared to become wider and wider. With the exception of a few "high-tech" buildings, the unity of art and applied science (technology in design seems facing challenges. It is interesting to see how fast and unexpectedly the situation has changed. Many factors and people played a role in this reversal, many new buildings demonstrate that utilitarian artifacts do not have to be oppressive to creativity but can evoke new innovation. One of the most significant contributors was JIN MAO TOWER at Shanghai, China. The paper analyses this building as a genuine synthesis of rational intelligence with art poetry that is still possible. Abstract in Bahasa Indonesia : Lebih dari dua dekade setelah timbulnya arsitektur pasca modern, pemisahan antara tekknologi konstruksi dan ekspresi kultural dalam arsitektur menjadi semakin lebar. Dengan perkecualian beberapa gedung "high-tech", kesatuan antara seni dan teknologi dalam tahap desain terlihat menghadapi tantangan tantangan. Tetapi menarik untuk diamati bahwa situasi telah berubah. Banyak faktor dan tokoh tokoh arsitek memegang peranan penting dalam perubahan ini, banyak bangunan bangunan baru mendemontrasikan bahwa artefak fungsionil tidak bearti menindas kreativitas namun dapat membangkitkan inovasi baru. Salah satu kontributor yang sangat penting adalah JIN MAO TOWER di Shanghai-China. Makalah ini membahas bangunan tersebut sebagai sintesis orijinal yang masih memungkinkan antara kecerdasan rasional dengan puisi seni arsitektur. Kata kunci: Sintesis.

  4. Predicting drunk driving: contribution of alcohol use and related problems, traffic behaviour, personality and platelet monoamine oxidase (MAO) activity.

    Science.gov (United States)

    Eensoo, Diva; Paaver, Marika; Harro, Maarike; Harro, Jaanus

    2005-01-01

    The aim of the study was to characterize the predictive value of socio-economic data, alcohol consumption measures, smoking, platelet monoamine oxidase (MAO) activity, traffic behaviour habits and impulsivity measures for actual drunk driving. Data were collected from 203 male drunk driving offenders and 211 control subjects using self-reported questionnaires, and blood samples were obtained from the two groups. We identified the combination of variables, which predicted correctly, approximately 80% of the subjects' belonging to the drunk driving and control groups. Significant independent discriminators in the final model were, among the health-behaviour measures, alcohol-related problems, frequency of using alcohol, the amount of alcohol consumed and smoking. Predictive traffic behaviour measures were seat belt use and paying for parking. Among the impulsivity measures, dysfunctional impulsivity was the best predictor; platelet MAO activity and age also had an independent predictive value. Our results support the notion that drunk driving is the result of a combination of various behavioural, biological and personality-related risk factors.

  5. Modeling the dynamic equilibrium between oligomers of (AlOCH3)n in methylaluminoxane (MAO). A theoretical study based on a combined quantum mechanical and statistical mechanical approach.

    Science.gov (United States)

    Zurek, E; Woo, T K; Firman, T K; Ziegler, T

    2001-01-15

    Density functional theory (DFT) has been used to calculate the energies of 36 different methylaluminoxane (MAO) cage structures with the general formula (MeAlO)n, where n ranges from 4 to 16. A least-squares fit has been used to devise a formula which predicts the total energies of the MAO with different n's giving an rms deviation of 4.70 kcal/mol. These energies in conjunction with frequency calculations based on molecular mechanics have been used to estimate the finite temperature enthalpies, entropies, and free energies for these MAO structures. Furthermore, formulas have been devised which predict finite temperature enthalpies and entropies for MAO structures of any n for a temperature range of 198.15-598.15 K. Using these formulas, the free energies at different temperatures have been predicted for MAO structures where n ranges from 17 to 30. The free energy values were then used to predict the percentage of each n found at a given temperature. Our calculations give an average n value of 18.41, 17.23, 16.89, and 15.72 at 198.15, 298.15, 398.15, and 598.15 K, respectively. Topological arguments have also been used to show that the MAO cage structure contains a limited amount of square faces as compared to octagonal and hexagonal ones. It is also suggested that the limited number of square faces with their strained Al-O bonds explain the high molar Al:catalyst ratio required for activation. Moreover, in this study we outline a general methodology which may be used to calculate the percent abundance of an equilibrium mixture of oligomers with the general formula (X)n.

  6. The MAO-A inhibitor clorgyline reduces ethanol-induced locomotion and its volitional intake in mice.

    Science.gov (United States)

    Ledesma, Juan Carlos; Escrig, Miguel Angel; Pastor, Raúl; Aragon, Carlos M G

    2014-01-01

    Hydrogen peroxide is the co-substrate used by the enzyme catalase to form Compound I (the catalase-H2O2 system), which is the major pathway for the conversion of ethanol (EtOH) into acetaldehyde in the brain. This acetaldehyde has been involved in many of the effects of EtOH. Previous research demonstrated that treatments that change the levels of cerebral H2O2 available to catalase modulate the locomotor-stimulating effects of EtOH and its volitional intake in rodents. However, the source of H2O2 which is used by catalase to form Compound I and mediates the psychoactive actions of EtOH is unknown. One cause of the generation of H2O2 in the brain comes from the deamination of biogenic amines by the activity of MAO-A. Here we explore the consequences of the administration of the MAO-A inhibitor clorgyline on EtOH-induced locomotion and voluntary EtOH drinking. For the locomotor activity tests, we injected Swiss (RjOrl) mice intraperitoneally (IP) with clorgyline (0-10mg/kg) and later (0.5-8h) with EtOH (0-3.75 g/kg; IP). Following these treatments, mice were placed in locomotor activity chambers to measure their locomotion. For the drinking experiments, mice of the C57BL/6J strain were injected IP with clorgyline prior to offering them an EtOH (20%) solution following a drinking-in-the-dark procedure. Additional experiments were performed to assess the selectivity of this compound in altering EtOH-stimulated locomotion and EtOH intake. Moreover, we indirectly tested the ability of clorgyline to reduce brain H2O2 levels. We showed that this treatment selectively reduced EtOH-induced locomotion and its self-administration. Moreover, this compound decreased central H2O2 levels available to catalase. We suggest that H2O2 derived from the deamination of biogenic amines by the activity of MAO-A could determine the formation of brain EtOH-derived acetaldehyde. This centrally-formed acetaldehyde within the neurons of the aminergic system could play a role in the

  7. Speech at the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instruction on Western Medicine Doctors Learning Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhu

    2009-01-01

    @@ Respected leaders, distinguished guests, venerable seniors and comrades, Today, the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instructions on Western Medicine Doctors Learning Traditional Chinese Medicine was inaugurated by the Chinese Association of Integrative Medicine, and it is also an important occasion to review the past and look forward to the future.

  8. Metallocene-catalyzed ethylene−α-olefin isomeric copolymerization: A perspective from hydrodynamic boundary layer mass transfer and design of MAO anion

    KAUST Repository

    Adamu, Sagir; Atiqullah, Muhammad; Malaibari, Zuhair O.; Al-Harthi, Mamdouh A.; Emwas, Abdul-Hamid M.; Ul-Hamid, Anwar

    2015-01-01

    -catalyzed ethylene polymerization. This approach was illustrated by conducting homo- and isomeric copolymerization of ethylene with 1-hexene and 4-methyl-1-pentene in the presence of bis(n-butylcyclopentadienyl) zirconium dichloride (nBuCp)2ZrCl2, using (i) MAO anion

  9. Metallocene-catalyzed ethylene−α-olefin isomeric copolymerization: A perspective from hydrodynamic boundary layer mass transfer and design of MAO anion

    KAUST Repository

    Adamu, Sagir

    2015-11-28

    This study reports a novel conceptual framework that can be easily experimented to evaluate the effects of hydrodynamic boundary layer mass transfer, methylaluminoxane (MAO) anion design, and comonomer steric hindrance on metallocene-catalyzed ethylene polymerization. This approach was illustrated by conducting homo- and isomeric copolymerization of ethylene with 1-hexene and 4-methyl-1-pentene in the presence of bis(n-butylcyclopentadienyl) zirconium dichloride (nBuCp)2ZrCl2, using (i) MAO anion 1 (unsupported [MAOCl2]−) and pseudo-homogeneous reference polymerization, and (ii) MAO anion 2 (supported Si−O−[MAOCl2]−) and in-situ heterogeneous polymerization. The measured polymer morphology, catalyst productivity, molecular weight distribution, and inter-chain composition distribution were related to the locus of polymerization, comonomer effect, in-situ chain transfer process, and micromixing effect, respectively. The peak melting and crystallization temperatures and %crystallinity were mathematically correlated to the parameters of microstructural composition distributions, melt fractionation temperatures, and average lamellar thickness. These relations showed to be insightful. The comonomer-induced enchainment defects and the eventual partial disruption of the crystal lattice were successfully modeled using Flory and Gibbs–Thompson equations. The present methodology can also be applied to study ethylene−α-olefin copolymerization, performed using MAO-activated non-metallocene precatalysts.

  10. Lessons Learned

    Directory of Open Access Journals (Sweden)

    Amanda Phelan BNS, MSc, PhD

    2015-03-01

    Full Text Available The public health nurses’ scope of practice explicitly includes child protection within their role, which places them in a prime position to identify child protection concerns. This role compliments that of other professions and voluntary agenices who work with children. Public health nurses are in a privileged position as they form a relationship with the child’s parent(s/guardian(s and are able to see the child in its own environment, which many professionals cannot. Child protection in Ireland, while influenced by other countries, has progressed through a distinct pathway that streamlined protocols and procedures. However, despite the above serious failures have occurred in the Irish system, and inquiries over the past 20 years persistently present similar contributing factors, namely, the lack of standardized and comprehensive service responses. Moreover, poor practice is compounded by the lack of recognition of the various interactional processes taking place within and between the different agencies of child protection, leading to psychological barriers in communication. This article will explore the lessons learned for public health nurses practice in safeguarding children in the Republic of Ireland.

  11. Photographic Observations of Major Planets and Their Moons During 1961-1990 at the MAO NAS of Ukraine

    Science.gov (United States)

    Yizhakevych, O. M.; Andruk, V. M.; Pakuliak, L. K.

    We present the results of photographic observations' processing of Saturn's moons, Uranus, Neptune and their moons on the basis of MAO NAS of Ukraine photographic observational archive. The analysis of the results is given. Observations were obtained using 4 telescopes: Double Long-Focus Astrograph (DLFA, D/F = 400/5500), Zeiss Double Astrograph (DAZ, D/F= 400/3000), Reflector Zeiss-600 (D/F= 600/7500), Wideangle Astrograph, (DWA, D/F= 400/2000). Observations were carried out during 1961 - 1990 (http://gua.db.ukrvo. org). Digitizing of plates has been done by EPSON EXPRESSION 10000XL (EE) flatbed scanner in 16-bit gray color range with resolution 1200dpi.(Andruk et al.: 2005, 2012; Golovnja et al.: 2010;. Protsyuk et al. 2014a, 2014b). The reduction of plates was made using the software developed in MAO NASU in the enhanced LINUX-MIDAS software kit. (Andruk V. et al.: 2016a, 2016b). Tycho2 was used as a reference system. The internal accuracy of the reduction for the first three instruments is ±0.08 - ±0.13 arcsec for both coordinates. For the wide angle astrograph DWA, RMS errors appeared 2 - 2.5 times higher. The total amount of processed plates with images of Saturn's moons is 209 (511 frames), 33 plates contain the images of Uranus and U1,U2,U3,U4 moons, 29 plates have images of Neptune and N1 moon (Yizhakevych et al., 2015, 2016, 2017; Protsyuk et al., 2015). The online comparison of calculated positions of objects with IMCCE ephemeris data was made (http://lnfm1.sai.msu.ru/neb/nss/nssephmf.htm).

  12. Effects of Condensed Tannins in Mao ( Muell. Arg. Seed Meal on Rumen Fermentation Characteristics and Nitrogen Utilization in Goats

    Directory of Open Access Journals (Sweden)

    P. Gunun

    2016-08-01

    Full Text Available Mao seed is a by-product of the wine and juice industry, which could be used in animal nutrition. The current study was designed to determine the effect of supplementation of mao (Antidesma thwaitesianum Muell. Arg. seed meal (MOSM containing condensed tannins (CT on rumen fermentation, nitrogen (N utilization and microbial protein synthesis in goats. Four crossbred (Thai Native×Anglo Nubian goats with initial body weight (BW 20±2 kg were randomly assigned to a 4×4 Latin square design. The four dietary treatments were MOSM supplementation at 0%, 0.8%, 1.6%, and 2.4% of total dry matter (DM intake, respectively. During the experimental periods, all goats were fed a diet containing roughage to concentrate ratio of 60:40 at 3.0% BW/d and pangola grass hay was used as a roughage source. Results showed that supplementation with MOSM did not affect feed intake, nutrient intakes and apparent nutrient digestibility (p>0.05. In addition, ruminal pH and ammonia nitrogen (NH3-N were not influenced by MOSM supplementation, whilst blood urea nitrogen was decreased quadraticly (p0.05. There were linear decreases in urinary N (p0.05. From the current study, it can be concluded that supplementation of MOSM at 1.6% to 2.4% of total DM intake can be used to modify ruminal fermentation, especially propionate and N utilization in goats, without affecting the nutrient digestibility, microbial populations and microbial protein synthesis.

  13. The Knitting Lesson.

    Science.gov (United States)

    Smith, Pamela

    1987-01-01

    Based on Jean-Francois Millet's 1869 painting, "The Knitting Lesson," this lesson's goal is to introduce students in grades seven through nine to genre (everyday life) painting the nineteenth century. The lesson is also designed to show that some aspects of genre may be timeless. (BSR)

  14. Lessons learned bulletin

    International Nuclear Information System (INIS)

    1994-05-01

    During the past four years, the Department of Energy -- Savannah River Operations Office and the Westinghouse Savannah River Company (WSRC) Environmental Restoration (ER) Program completed various activities ranging from waste site investigations to closure and post closure projects. Critiques for lessons learned regarding project activities are performed at the completion of each project milestone, and this critique interval allows for frequent recognition of lessons learned. In addition to project related lessons learned, ER also performs lessons learned critiques. T'he Savannah River Site (SRS) also obtains lessons learned information from general industry, commercial nuclear industry, naval nuclear programs, and other DOE sites within the complex. Procedures are approved to administer the lessons learned program, and a database is available to catalog applicable lessons learned regarding environmental remediation, restoration, and administrative activities. ER will continue to use this database as a source of information available to SRS personnel

  15. Effect of ultrasonic cold forging technology as the pretreatment on the corrosion resistance of MAO Ca/P coating on AZ31B Mg alloy

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lingling, E-mail: daisy_chenlingling@163.com [College of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China); College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029 (China); Gu, Yanhong, E-mail: gu_yanhong@163.com [College of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China); Liu, Lu, E-mail: liulu@bipt.edu.cn [College of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China); Liu, Shujing, E-mail: liushujing@bipt.edu.cn [College of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China); Hou, Binbin, E-mail: sohu19880815@126.com [School of Engineering and Technology, China University of Geosciences, Beijing 100083 (China); Liu, Qi, E-mail: 13521196884@sina.cn [College of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China); Ding, Haiyang, E-mail: dinghaiyang@bipt.edu.cn [College of Mechanical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617 (China)

    2015-06-25

    Highlights: • Ultrasonic cold forging technology was used as the pretreatment for MAO coating. • Nano layer with the grain size of 30–80 nm was formed on the UCFT treated surface. • Calcium phosphate contained coating was obtained by MAO process. • The remained nano layer underlying MAO coating could impact the corrosion resistance greatly. - Abstract: A calcium phosphate contained (Ca/P) coating was obtained on AZ31B Mg alloy by micro-arc oxidation (MAO) process under the pretreatment of ultrasonic cold forging technology (UCFT). The surface nanograins were introduced after UCFT pretreatment on AZ31B Mg alloy. Optical microscope (OM) was employed to observe the microstructures of the untreated and UCFT treated samples. Transmission electron microscopy (TEM) and atomic force microscope (AFM) were employed to observe the microstructures of nanograins and the surface roughness of the UCFT treated Mg alloys. The grain size of the UCFT treated Mg alloy is 48.67 nm and the surface roughness is 17.03 nm. The microstructures and the phase compositions of MAO samples were observed and analyzed by scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. The XRD results show that the coating include Ca/P phase, including hydroxyapatite (Ca{sub 10}(PO{sub 4}){sub 6}(OH){sub 2}), HA), tertiary calcium phosphate (Ca{sub 3}(PO{sub 4}){sub 2}, TCP) and calcium phosphate dehydrate (CaHPO{sub 4}⋅2H{sub 2}O, DCPD). The hardness of the samples was measured by the micro-hardness tester under the loads of 10 g, 25 g and 50 g. 3D topographies of hardness indenter were characterized by 3D profiler. The immersion tests and potentiodynamic polarization tests were used to evaluate the weight loss rate and corrosion current density in simulated body fluid (SBF). The results show that the corrosion resistance of Ca/P MAO coating on Mg alloy was improved greatly by the pretreatment of UCFT.

  16. Comparison of two synthetic methods to obtain [18F] N-(2-aminoethyl)-5-fluoropyridine-2-carboxamide, a potential MAO-B imaging tracer for PET

    International Nuclear Information System (INIS)

    Beer, H.-F.; Haeberli, M.; Ametamey, S.; Schubiger, P.A.

    1995-01-01

    The compound Ro 19-6327, N-(2-aminoethyl)-5-chloropyridine-2-carboxamide, is known to inhibit reversibly and site specifically the enzyme monoamine oxidase B (MAO-B). The 123 I-labelled iodo-analogue N-(2-aminoethyl)-5-iodopyridine-2-carboxamide (Ro 43-0463) was investigated successfully in human volunteers by means of SPET (Single Photon Emission Tomography). We developed therefore the synthesis and radiolabelling of the corresponding fluoro-analogue N-(2-aminoethyl)-5-fluoropyridine-2-carboxamide with 18 F in order to carry out PET (Positron Emission Tomography) investigations of MAO-B related neuropsychiatric diseases. For this purpose two synthetic approaches leading to the electrophilic and the nucleophilic methods of 18 F radiolabelling were undertaken. The nucleophilic approach appeared to be superior when factors such as precursor synthesis, beam time, specific activity and radiochemical purity of the product are considered. (author)

  17. Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration.

    Science.gov (United States)

    Tzvetkov, Nikolay T; Antonov, Liudmil

    2017-12-01

    Pharmacological and physicochemical studies of N-unsubstituted indazole-5-carboxamides (subclass I) and their structurally optimised N1-methylated analogues (subclass II), initially developed as drug and radioligand candidates for the treatment and diagnosis of Parkinson's disease (PD), are presented. The compounds are highly brain permeable, selective, reversible, and competitive monoamine oxidase B (MAO-B) inhibitors with improved water-solubility and subnanomolar potency (pIC 50  >8.8). Using a well-validated, combined X-ray/modelling technology platform, we performed a semi-quantitative analysis of the binding modes of all compounds and investigated the role of the indazole N1 position for their MAO-B inhibitory activity. Moreover, compounds NTZ-1006, 1032, and 1441 were investigated for their ability to bind Fe 2+ and Fe 3+ ions using UV-visible spectroscopy.

  18. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

    Science.gov (United States)

    Samadi, Abdelouahid; de los Ríos, Cristóbal; Bolea, Irene; Chioua, Mourad; Iriepa, Isabel; Moraleda, Ignacio; Bartolini, Manuela; Andrisano, Vincenza; Gálvez, Enrique; Valderas, Carolina; Unzeta, Mercedes; Marco-Contelles, José

    2012-06-01

    The synthesis, pharmacological evaluation and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amines 1-7 of type I, and 9-12 of type II, designed as multipotent inhibitors able to simultaneously inhibit monoamine oxidases (MAO-A/B) as well as cholinesterase (AChE/BuChE) enzymes, as potential drugs for the treatment of Alzheimer's disease, are described. Indole derivatives 1-7 of type I are well known MAO inhibitors whose capacity to inhibit AChE and BuChE was here investigated for the first time. As a result, compound 7 was identified as a MAO-B inhibitor (IC(50) = 31 ± 2 nM) and a moderately selective eqBuChE inhibitor (IC(50) = 4.7 ± 0.2 μM). Conversely, the new and readily available 5-amino-7-(prop-2-yn-1-yl)-6,7,8,9-tetrahydropyrido[2,3-b][1,6]naphthyridine derivatives 9-13 of type II are poor MAO inhibitors, but showed AChE selective inhibition, compound 12 being the most attractive as it acts as a non-competitive inhibitor on EeAChE (IC(50) = 25 ± 3 nM, K(i) = 65 nM). The ability of this compound to interact with the AChE peripheral binding site was confirmed by kinetic studies and by molecular modeling investigation. Studies on human ChEs confirmed that 12 is a selective AChE inhibitor with inhibitory potency in the submicromolar range. Moreover, in agreement with its mode of action, 12 was shown to be able to inhibit Aβ aggregation induced by hAChE by 30.6%. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  19. Tautomerism of N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide - A new selective, highly potent and reversible MAO-B inhibitor

    Science.gov (United States)

    Tzvetkov, Nikolay T.; Stammler, Hans-Georg; Antonov, Liudmil

    2017-12-01

    The tautomeric properties of an N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide (NTZ-1006, 2) derivative, developed as highly potent, reversible and selective MAO-B inhibitor useful for the treatment of Parkinson's disease (PD) and other neurological disorders, have been studied both experimentally and theoretically. The theoretical data (M06-2X, B3LYP and MP2-4 quantum chemical calculations) have shown that due to aromaticity reasons the 1H tautomer strongly dominates over the 2H form. There are no substantial spectral changes by changing the solvent and the concentration, which leads to a conclusion that compound 2 exists in solution as 1H tautomer and its tautomerism is not influenced by the solvents and the concentration. The results are in line with the understanding for the tautomerism of 1H-indazole and shows that substitution at the C5 position in the indazole unit does not influence the tautomeric state. The isolated crystal structure of 2 is in an excellent agreement with the computation in respect of the most stable tautomer. Combined single X-ray/molecular modeling studies including HYdrogen-DEsolvation (HYDE) analysis provided not only insights into the enzyme-inhibitor interaction within the binding site of the human MAO-B isoform, but also a valuable information regarding the most stable 1H-indazole tautomeric form of NTZ-1006 that contributes to its high potency against hMAO-B enzyme (IC50 0.586 nm) and selectivity (>17000-fold) over the hMAO-A isoenzyme.

  20. Identification of Single Nucleotide Polymorphism (SNP in Mono Amine Oxidase A (MAO-A Gene as a genetic marker for aggressiveness in sheep

    Directory of Open Access Journals (Sweden)

    Eko Handiwirawan

    2012-12-01

    Full Text Available In the population, there are aggressive sheep in a small number which requires special management those specific animal house and routine management. The purpose of this study was to identify the variation of DNA marker SNP (single nucleotide polymorphism as a genetic marker for the aggressive trait in several of sheep breed. The identification of point mutations in exon 8 of MAO-A gene associated with aggressive behavior in sheep may be further useful to become of DNA markers for the aggressive trait in sheep. Five of sheep breed were used, i.e.: Barbados Black belly Cross sheep (BC, Composite Garut (KG, Local Garut (LG, Composite Sumatra (KS and St. Cross Croix (SC. Duration of ten behavior traits, blood serotonin concentrations and DNA sequence of exon 8 of MAO-A gene from the sheep aggressive and nonaggressive were observed. PROC GLM of SAS Ver. 9.0 program was used to analyze variable behavior and blood serotonin concentrations. DNA polymorphism in exon 8 of MAO-A gene was analyzed using the MEGA software Ver. 4.0. The results show that the percentage of the aggressive rams of each breed was less than 10 percent; except for the KS sheep is higher (23%. Based on the duration of behavior, aggressive sheep group was not significantly different with non aggressive sheep group, except duration of care giving and drinking behavior. It is known that concentration of blood serotonin in aggressive and non aggressive rams was not significantly different. The aggressive trait in sheep has a mechanism or a different cause like that occurs in mice and humans. In this study, aggressive behavior in sheep was not associated with a mutation in exon 8 of MAO-A gene.

  1. Characteristics of MAO coating obtained on ZK60 Mg alloy under two and three steps voltage-increasing modes in dual electrolyte

    Science.gov (United States)

    Yang, Jun; Wang, Ze-Xin; Lu, Sheng; Lv, Wei-gang; Jiang, Xi-zhi; Sun, Lei

    2017-03-01

    The micro-arc oxidation process was conducted on ZK60 Mg alloy under two and three steps voltage-increasing modes by DC pulse electrical source. The effect of each mode on current-time responses during MAO process and the coating characteristic were analysed and discussed systematically. The microstructure, thickness and corrosion resistance of MAO coatings were evaluated by scanning electron microscopy (SEM), energy disperse spectroscopy (EDS), microscope with super-depth of field and electrochemical impedance spectroscopy (EIS). The results indicate that two and three steps voltage-increasing modes can improve weak spark discharges with insufficient breakdown strength in later period during the MAO process. Due to higher value of voltage and voltage increment, the coating with maximum thickness of about 20.20μm formed under two steps voltage-increasing mode shows the best corrosion resistance. In addition, the coating fabricated under three steps voltage-increasing mode shows a smoother coating with better corrosion resistance due to the lower amplitude of voltage-increasing.

  2. Lesson study i Danmark?

    DEFF Research Database (Denmark)

    Mogensen, Arne

    2009-01-01

    Der beskrives et japansk lesson study forløb, og det diskuteres i hvilket omfang, de gode japanske erfaringer kan overføres til dansk matematikundervisning.......Der beskrives et japansk lesson study forløb, og det diskuteres i hvilket omfang, de gode japanske erfaringer kan overføres til dansk matematikundervisning....

  3. "Frankenstein." [Lesson Plan].

    Science.gov (United States)

    Simon, Melanie

    Based on Mary Shelley's novel "Frankenstein," this lesson plan presents activities designed to help students understand that active readers interpret a novel (its characters, plot, setting, and theme) in different ways; and the great literature can be and has been adapted in many ways over time. The main activity of the lesson involves students…

  4. The history of a lesson

    DEFF Research Database (Denmark)

    Rasmussen, Mikkel Vedby

    2003-01-01

    and emphasises the need to study the history of lessons rather than the lessons of history. This approach shows that Munich is the end point of a constitutive history that begins in the failure of the Versailles treaty to create a durable European order following the First World War. The Munich lesson is thus......The article investigates the concept of lessons in IR. By means of a constructivist critique of the 'lessons literature', the article analyses one of the most important of IR lessons: that of Munich. Examining how the Munich lesson came about, the article shows the praxeological nature of lessons...... one element of the lesson of Versailles, which is a praxeology that defines how the West is to make peace, and against whom peace must be defended. The lesson of Versailles has been, at least in part, constitutive of the outbreak of the Cold War, and it continues to define the Western conception...

  5. PF 9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine], a new MAO-B inhibitor, attenuates MPTP-induced depletion of striatal dopamine levels in C57/BL6 mice.

    Science.gov (United States)

    Perez, Virgili; Unzeta, Mercedes

    2003-02-01

    Monoamine oxidase isoform B (MAO-B) is involved in Parkinson's disease (PD) induced by the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxin (MPTP) in human and non-human-primate. MAO-B inhibitors, such as L-deprenyl have shown to prevent against MPTP-toxicity in different species, and it has been used in Parkinson therapy, however, the fact that it is metabolized to (-)-methamphetamine and (-)-amphetamine highlights the need to find out new MAO-B inhibitors without a structural amphetaminic moiety. In this context we herein report, for the first time, anywhere a novel non-amphetamine-like MAO-B inhibitor, PF 9601N, N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine. This attenuates the MPTP-induced striatal dopamine depletion in young-adult and adult-old C57/BL mice, using different schedules of administration, and which behave "ex vivo" as a slightly more potent and selective MAO-B inhibitor than L-deprenyl, assayed for comparative purposes in the same experimental conditions. The MAO-B ID(50) values were calculated from the total MAO-B activity measured against [14C] phenylethylamine (22 microM) as substrate, at each inhibitor concentration. The MAO-B ID(50) values resulted to be 381 and 577 nmol/kg for PF 9601N and L-deprenyl, respectively. The intraperitoneally (i.p.) co-administration to young-adult C57/BL6 mice of MPTP (30 mg/kg), with different concentrations of PF 9601N or L-deprenyl (29.5-0.357 micromol/kg) showed a dose-dependent protective effect against striatal dopamine depletion, measuring the dopamine contents and its metabolites by HPLC. The ED(50) value proved to be 3.07 micromol/kg without any significant differences between either MAO-B inhibitor. Nevertheless, lower doses of PF 9601N (1.5 micromol/kg) were necessary to get almost total protection, without any change in the DOPAC and HVA content, when administered 2 h before MPTP (30 mg/kg), whereas partial protection (45%) against dopamine depletion was observed in the case of L-deprenyl. In

  6. Methodology and Mao

    DEFF Research Database (Denmark)

    Duncan, Russell

    2010-01-01

    A personal narrative is presented that reflects on the author's experience teaching United States history in China......A personal narrative is presented that reflects on the author's experience teaching United States history in China...

  7. Biological nutrient removal and molecular biological characteristics in an anaerobic-multistage anaerobic/oxic (A-MAO) process to treat municipal wastewater.

    Science.gov (United States)

    Huang, Xiao; Dong, Wenyi; Wang, Hongjie; Jiang, Shilong

    2017-10-01

    This study aimed to present an anaerobic-multistage anaerobic/oxic (A-MAO) process to treat municipal wastewater. The average COD, NH 4 + -N, TN, and TP removal efficiency were 91.81%, 96.26%, 83.73% and 94.49%, respectively. Temperature plunge and C/N decrease have a certain impact on the modified process. Characteristics of microbial community, function microorganism, and correlation of microbial community with environmental variables in five compartments were carried out by Illumina Miseq high-throughput sequencing. The differences of microbial community were observed and Blastocatella, Flavobacterium and Pseudomonas were the dominant genus. Nitrosomonas and Nitrospira occupied a dominant position in AOB and NOB, respectively. Rhodospirillaceae and Rhodocyclaceae owned a considerable proportion in phosphorus removal bacteria. DO and COD played significant roles on affecting the microbial components. The A-MAO process in this study demonstrated a high potential for nutrient removal from municipal wastewater. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Breathing Life into Engineering: A Lesson Study Life Science Lesson

    Science.gov (United States)

    Lawrence, Maria; Yang, Li-Ling; Briggs, May; Hession, Alicia; Koussa, Anita; Wagoner, Lisa

    2016-01-01

    A fifth grade life science lesson was implemented through a lesson study approach in two fifth grade classrooms. The research lesson was designed by a team of four elementary school teachers with the goal of emphasizing engineering practices consistent with the "Next Generation Science Standards" (NGSS) (Achieve Inc. 2013). The fifth…

  9. Lessons for Teaching Art Criticism.

    Science.gov (United States)

    Barrett, Terry, Ed.; Clark, Gilbert, Ed.

    This collection of lessons is meant to be a practical guide to help teachers engage children in art criticism. The lessons generally follow a similar format. Most suggest an age group but may be modified for use with younger or older students. Several authors suggest variations and extensions for lessons that include studio activities. A broad…

  10. Lesson Planning the Kodaly Way.

    Science.gov (United States)

    Boshkoff, Ruth

    1991-01-01

    Discusses the contribution of Zoltan Kodaly to music lesson planning. Emphasizes preparation, presentation, and practice as the three important strategies in teaching concepts and skills to be included in a lesson plan. Includes a sample lesson plan covering a semester and advice on choosing song material. (DK)

  11. Brothers Grimm. [Lesson Plan].

    Science.gov (United States)

    Discovery Communications, Inc., Bethesda, MD.

    Based on Grimm's fairy tales, this lesson plan presents activities designed to help students understand that fairy tales connect them to earlier generations, help them think about present situations, that magic figures prominently in fairy tales, and that fairy tales can inspire readers to create original works of art. The main activity in the…

  12. DSCOVR Contamination Lessons Learned

    Science.gov (United States)

    Graziani, Larissa

    2015-01-01

    The Triana observatory was built at NASA GSFC in the late 1990's, then placed into storage. After approximately ten years it was removed from storage and repurposed as the Deep Space Climate Observatory (DSCOVR). This presentation outlines the contamination control program lessons learned during the integration, test and launch of DSCOVR.

  13. Phagocytosis: history's lessons.

    Science.gov (United States)

    Garg, Manish; Chandawarkar, Rajiv Y

    2013-01-01

    The assimilation of lessons from the past is an essential component of education for scientists of tomorrow. These lessons are not easy to find. History books on science are few and usually highly dramatized and biographies of scientists tend to exaggerate the pomp of scientific discovery. Both underplay the hard and laborious work that is integral to any scientific pursuit. Here we illustrate one such example. A century ago, the Nobel Prize in Medicine was awarded to two scientists: Ilya Metchnikoff, a Russian zoologist, for the discovery ofphagocytosis-a cell-mediated ingestion ofmicrobes; and Paul Ehrlich, a distinguished physician-scientist, for discovering a highly antigen-specific serum-derived antibody-based immune defense. These two diametrically opposing views of the host-pathogen interaction set the stage for a strife that led to seminal advancements in immunology. Mirrored in this journey are important lessons for scientists today--ubiquitously as applicable to modern scientific life as they were a century ago. This commentaryhighlights these lessons--a fitting centenary to a well-deserved recognition.

  14. Recycling Lesson Plan

    Science.gov (United States)

    Okaz, Abeer Ali

    2013-01-01

    This lesson plan designed for grade 2 students has the goal of teaching students about the environmental practice of recycling. Children will learn language words related to recycling such as: "we can recycle"/"we can't recycle" and how to avoid littering with such words as: "recycle paper" and/or "don't throw…

  15. Smart Consumer Lesson Plans.

    Science.gov (United States)

    New Jersey Consortium for Consumer Education, Newark.

    Lesson plans are provided for use with different populations of pre-K through senior high school students in four different areas of consumer education. Eight units in advertising are included: A First Look at Ads (pre-K-Grade 3), Don't Judge a Book by Its Cover (Grades 1-3), Fatal Distraction (Junior High), Package Labeling (Junior High), Product…

  16. Effect of alumina sol addition to micro-arc oxidation electrolyte on the properties of MAO coatings formed on magnesium alloy AZ91D

    International Nuclear Information System (INIS)

    Laleh, M.; Rouhaghdam, A. Sabour; Shahrabi, T.; Shanghi, A.

    2010-01-01

    Oxide coatings were formed on AZ91D magnesium alloy using micro-arc oxidation process in alkaline electrolyte without and with addition of alumina sol. The microstructures and compositions of the MAO coatings were analyzed by scanning electron microscope (SEM) and X-ray diffraction (XRD). Corrosion behaviors of the coatings were evaluated with electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization tests in 3.5%NaCl solution. Porosities of the coatings were measured by potentiodynamic polarization tests. It was found that the coating produced in the electrolyte with alumina sol has more compact and uniform morphology than that produced in the electrolyte without alumina sol. The results of corrosion tests showed that the coating formed in electrolyte with alumina sol enhances the corrosion resistance of the substrate significantly. XRD patterns showed that the coating produced in the electrolyte with alumina sol has more MgAl 2 O 4 phase than MgO.

  17. A proteomics study reveals a predominant change in MaoB expression in platelets of healthy volunteers after high protein meat diet

    DEFF Research Database (Denmark)

    Zellner, Maria; Babeluk, Rita; Jakobsen, Lene Holm

    2011-01-01

    Studies investigating the impact of high meat intake on cognition have yielded contradictory results as some show improved cognitive performance, whereas others report an increase of risk factors for dementia. However, few studies were designed to directly assess the effect of a high protein (HP...... reproducibly studied platelet proteins only the level of monoamine oxidase B (MaoB), a neurotransmitter degrading enzyme, decreased by 26% significantly (adjusted P value diet. In addition, we found a correlation (r = 0.477; P ...) diet on both cognitive performance and corresponding biochemical parameters. A randomised intervention study was conducted with 23 healthy males (aged 19-31 years) to investigate the effects of a usual (UP) versus a HP diet on cognitive function and on the platelet proteome a well-established model...

  18. Antibacterial Activities of Green Basil (Ocimum Violaceum Essential Oil and Derivatives By MAOS (Microwave Assisted Organic Synthesis Against Staphyllococus Aureus and Escherichia Coli

    Directory of Open Access Journals (Sweden)

    Dwiarso Rubiyanto

    2014-07-01

    Full Text Available Green basil (Ocimum violaceum , Linn. plantis part of the varieties of basil (Ocimum basilicum, Linn.. Green basil essential oil (GBEO contain chemical compounds that have an anti- bacterial activities . Methyl eugenol and methyl chavikol are in green basil oil has the potential to be used as a material which is biologically active. Conversion reaction of the compounds in GBEO with MAOS methods (microwave assisted organic synthesis aims to obtain properties of the main chemical component in a wider sweet basil oil, and are also useful in an attempt to gain more valuable compounds for commercial and higher. The results showed that the optimum reaction conditions on the conversion reaction of compounds in GBEO with MAOS method with ethylene glycol as a solvent is 10 % KF/Al2O3as catalyst and reaction time 3 minutes , while the solvent is glycerol 10 % KF/Al2O3as catalyst and reaction time 2 minutes . Comparison of anti-bacterial activity resulting from this research are : the inhibitory activity to the growth of S. aureus bacteria have the following order : GBEO > green basilEG10-3 > green basil G10-2> amoxicillin with each inhibition zone diameter amounted to 30.7 mm, 21.1 mm, 18.2 mm and 13.4 mm. While the inhibitory activity to the growth of E.coli bacteria are : GBEO> green basil G10-2 >green basil EG10-3 > amoxicillin with each inhibition zone diameter of 21.1 mm, 15.6 mm , 15.2 mm and 7.9 mm . GBEO and its derivatives have minimal inhibitory concentrations below 1.25 %. From the results of the study found that the main derivates obtained are p-methoxy anisaldehyde , caryophyllene oxide , 3-methoxy cinnamaldehyde , humulena oxide and delta cadinol

  19. Lessons from Goiania

    International Nuclear Information System (INIS)

    Nazari Alves, R.

    2000-01-01

    The lessons learned from the radiological accident of Goiania in 1987 derived from the observations from the Regulatory Agency which was in charge of the decontamination tasks may be consolidated into four classes: Preventive Actions, characterised as those that aim to minimise the probability of occurrence of a radiological accident; Minimisation of time between the moment of the accident occurrence and the beginning of intervention, in case a radiological accident does occur, despite all preventive measures; Intervention, which is correlated to the type of installation, its geographical location, the social classes involved and their contamination vectors; and Follow up, for which well established rules to allow continuing monitoring of the victims and rebuilding of homes are necessary. The greatest lesson of all was the need for integration of the professionals involved, from all organizations. (author)

  20. Paths to Victory: Lessons from Modern Insurgencies

    Science.gov (United States)

    2013-01-01

    1996 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 Laos , 1959–1975...1973–1978) Angola (UNITA) (1975–2002) Indonesia (Aceh) (1976–2005) Mozambique (RENAMO) (1976–1995) Cuba (1956–1959) Eritrea (1961–1991) Laos ...guerrilla must move amongst the people as a fish swims in the sea.” Mao Tse -tung, On Guerrilla Warfare, trans. Samuel B. Griffith II, Chicago, Ill

  1. A Hundred Osamas: Islamist Threats and the Future of Counterinsurgency

    National Research Council Canada - National Science Library

    Zuhur, Sherifa

    2005-01-01

    .... The author of this monograph, Dr. Sherifa Zuhur, examines the intensity and diversification of extremist efforts and outlines their "new jihad" and its relationship to the regeneration of extremist leadership...

  2. Osama's Wake: The Second Generation of Al Qaeda

    National Research Council Canada - National Science Library

    Ward, Blake D

    2005-01-01

    The National Security Strategy (NSS) of the United States inadequately defines the threat which on September 11, 2001, propelled the United States towards a Global War on Terrorism and redirected the nation's security efforts...

  3. Rumsfeld: Osama bin Ladenil polnud sidemeid Saddamiga / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2004-01-01

    Valeks on osutunud väide, et Saddam Husseini ja bin Ladeni vahel oli tihe koostöö. Autori sõnul uurisid Richard Cheney, Donald Rumsfeld ja USA praegune asekaitseminister Paul Wolfowitz juba 1990-ndate keskel võimalusi uueks sõjaks Iraagi vastu. Lisa: Bremer süüdistab Valget Maja

  4. Osama’s Wake: The Second Generation of Al Qaeda

    Science.gov (United States)

    2005-08-01

    Hilweh refugee camp in Lebanon.28 • Abu Bakar Bashir, the Indonesian cleric and co-leader of the Jemaah Islamiya (JI). Bashir has close contacts...and Abu Bakar Bashir (JI) can generate the finances, find the sanctuary, and attract willing volunteers, they have the equal potential to become...fall of the Ottoman sultanate in his video message of October 2001.3 The current struggle against Western civilization is categorized by salafist

  5. Masterwork Art Lesson: Kandinsky Watercolors.

    Science.gov (United States)

    LiPira, Michael

    2003-01-01

    Presents an art lesson used with sixth-grade students which also can be used with other grade levels. Explains that the artwork of Wassily Kandinsky served as inspiration for this lesson. Explains that the students learned about abstract art and used watercolors to create their own paintings in the style of Kandinsky. (CMK)

  6. Bead Game Simulation. Lesson Plan.

    Science.gov (United States)

    Ripp, Ken

    This lesson plan offers students the opportunity to participate in the three basic economic systems (market, command, and tradition). By working in each of the systems, students will internalize the fundamental values present in each system and will gain insights into the basic advantages and disadvantages of each system. The lesson plan provides…

  7. Simple and Practical Efficiency Lessons

    Science.gov (United States)

    Kolpin, Van

    2018-01-01

    The derivation of conditions necessary for Pareto efficient production and exchange is a lesson frequently showcased in microeconomic theory textbooks. Traditional delivery of this lesson is, however, limited in its scope of application and can be unnecessarily convoluted. The author shows that the universe of application is greatly expanded and a…

  8. Keiko, Killer Whale. [Lesson Plan].

    Science.gov (United States)

    Discovery Communications, Inc., Bethesda, MD.

    This lesson plan presents activities designed to help students understand that Keiko, the killer whale, lived for a long time in an aquarium and had to be taught to live independently; and that computer users can get updates on how Keiko is doing. The main activity of the lesson involves middle school students working in small groups to produce a…

  9. Lesson Study and History Education

    Science.gov (United States)

    Halvorsen, Anne-Lise; Kesler Lund, Alisa

    2013-01-01

    This article examines the experiences of a group of fifth-grade teachers who used lesson study, a teacher-driven form of professional development, to teach history in a project supported by a Teaching American History Grant. The project addressed the following questions: What does a lesson study cycle for history education look like? What…

  10. Classroom Management and Lesson Planning(4)

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Lesson PlanningTask 1As teachers,we all need to plan our lessons before we teach.Make a list of things that you think need tobe included in a lesson plan.Then compare and discuss your list with another teacher.Also think about reasonswhy we need to plan our lessons.

  11. Classroom Management and Lesson Planning(4)

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Lesson Planning Task 1 As teachers,we all need to plan our lessons before we teach.Make a list of things that you think need to be included in a lesson plan.Then compare and discuss your list with another teacher.Also think about reasons why we need to plan our lessons.

  12. Shuttle Lesson Learned - Toxicology

    Science.gov (United States)

    James, John T.

    2010-01-01

    This is a script for a video about toxicology and the space shuttle. The first segment is deals with dust in the space vehicle. The next segment will be about archival samples. Then we'll look at real time on-board analyzers that give us a lot of capability in terms of monitoring for combustion products and the ability to monitor volatile organics on the station. Finally we will look at other issues that are about setting limits and dealing with ground based lessons that pertain to toxicology.

  13. Homopolymerization of Ethylene, 1-Hexene, Styrene and Copolymerization of Styrene With 1,3-Cyclohexadiene Using (h5-Tetramethylcyclopentadienyldimethylsilyl(N-Ar’amido-TiCl2/MAO (Ar’=6-(2-(Diethylborylphenylpyrid-2-yl, Biphen-3-yl

    Directory of Open Access Journals (Sweden)

    Michael R. Buchmeiser

    2011-01-01

    Full Text Available The propensity of a half-sandwich (η5-tetramethylcyclopentadienyl dimethylsilylamido TiIV-based catalyst bearing an auxiliary diethylboryl-protected pyridyl moiety (Ti-8, activated by methylaluminoxane (MAO to homopolymerize α-olefins such as ethylene, 1-hexene and styrene as well as to copolymerize styrene with 1,3-cyclo-hexadiene is described. The reactivity of Ti-8 was investigated in comparison to a 6-(2-(diethylborylphenylpyrid-2-yl-free analogue (Ti-3.

  14. Structure and Infrared Emissivity Properties of the MAO Coatings Formed on TC4 Alloys in K2ZrF6-Based Solution

    Science.gov (United States)

    Li, Ying; Hu, Dan; Xi, Zhengping

    2018-01-01

    Micro-arc oxidation (MAO) ceramic coatings were formed on TC4 alloy surface in silicate and metaphosphate electrolytes based with K2ZrF6 for various concentrations. X-ray diffraction (XRD), Scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) were used to characterize the phase composition, microstructure and chemical compositions of the coatings. The infrared emissivity of the coatings was measured at 50 °C in a wavelength range of 8–20 µm. The microstructural observations all revealed the typical porousstructures. Moreover, adecline in roughness and thickness of the prepared coatings can be observed when the concentration of K2ZrF6 increases. Combined with the results of XRD and XPS, it was found that all the oxides existed as the amorphous form in the coatings except the TiO2 phase. The coatings exhibited the highest infrared emissivity value (about 0.89) when the concentration of K2ZrF6 was 6 g/L, which was possibly attributed to the defect microstructure and the optimal role of ZrO2. PMID:29414841

  15. Development of novel (1-H benzimidazole bearing pyrimidine-trione based MAO-A inhibitors: Synthesis, docking studies and antidepressant activity

    Directory of Open Access Journals (Sweden)

    Bijo Mathew

    2016-09-01

    Full Text Available The synthesis of some novel (1-H benzimidazole bearing pyrimidine-trione based MAO-A inhibitors were achieved by the reaction between 2E-1-(1H-benzimidazol-2-yl-3-phenylprop-2-en-1-ones(4a–f and barbituric acid in the presence of a catalytic amount of acetic acid medium. All the final structures were assigned on the basis of IR, 1HNMR and mass spectra analyses. All the synthesized derivatives showed good antidepressant activity when compared to the standard clomipiramine at a dose level of 20 mg/kg. The compound (5d 5-{(2E-1-(1H-benzimidazol-2-yl-3-[4-(dimethylaminophenyl] prop-2-en-1-ylidene} pyrimidine-2, 4, 6(1H,3H,5H-trione significantly reduced the duration of immobility times at 50 mg/kg−1 dose level when compared to the standard drug. Molecular docking studies revealed the need for an extra hydrophobic interaction in the titled scaffold for acquiring the promising experimental values. It has been concluded that the computational values obtained after the docking calculation are in good agreement with the experimental values.

  16. The effect of MAO processing time on surface properties and low temperature infrared emissivity of ceramic coating on aluminium 6061 alloy

    Science.gov (United States)

    Al Bosta, Mohannad M. S.; Ma, Keng-Jeng; Chien, Hsi-Hsin

    2013-09-01

    MAO ceramic coatings were prepared on aluminium 6061 surfaces at different treating durations (10, 20, ... 60 min), using alkali silicate electrolyte and pulsed bipolar current mode. The surface microstructures and properties were studied using SEM, XRD, EDX and a surface roughness tester. Image-Pro Plus and MATCH! softwares were used to analyze SEM micrographs and XRD results, respectively. The infrared emissivities of the ceramic coatings were measured at the 70 °C using FTIR spectrometer. We found a linear correlation between the volcano-like area and the surface roughness. The compositions and phases were associated with the volcano-like population and area. The curve of IR spectral emissivity was influenced by surface roughness, γ-alumina, sillimanite and cristobalite phases. The emissivity was enhanced by the surface roughness in the ranges 4.0-9.6 μm and 10.5-14.8 μm. In the range 7.0-8.0 μm, α-alumina and sillimanite phases enhanced the emissivity, while the cristobalite has a negative impact to the emissivity. A negative contributions were found for α-alumina in the region 9.6-16.0 μm and for the surface thickness in the region 15.0-16.0 μm. Overall, the average of long wave infrared (LWIR) emissivity ranged from 87.05% to 91.65%.

  17. Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

    Directory of Open Access Journals (Sweden)

    Leonardo Pisani

    2016-03-01

    Full Text Available The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD, shifted research towards reliable drug discovery strategies to unveil clinical candidates with higher therapeutic efficacy than single-targeting drugs. By following the multi-target approach, we designed and synthesized a novel class of dual acetylcholinesterase (AChE-monoamine oxidase B (MAO-B inhibitors through the decoration of the 2H-chromen-2-one skeleton. Compounds bearing a propargylamine moiety at position 3 displayed the highest in vitro inhibitory activities against MAO-B. Within this series, derivative 3h emerged as the most interesting hit compound, being a moderate AChE inhibitor (IC50 = 8.99 µM and a potent and selective MAO-B inhibitor (IC50 = 2.8 nM. Preliminary studies in human neuroblastoma SH-SY5Y cell lines demonstrated its low cytotoxicity and disclosed a promising neuroprotective effect at low doses (0.1 µM under oxidative stress conditions promoted by two mitochondrial toxins (oligomycin-A and rotenone. In a Madin-Darby canine kidney (MDCKII-MDR1 cell-based transport study, Compound 3h was able to permeate the BBB-mimicking monolayer and did not result in a glycoprotein-p (P-gp substrate, showing an efflux ratio = 0.96, close to that of diazepam.

  18. St. Louis FUSRAP Lessons Learned

    International Nuclear Information System (INIS)

    Eberlin, J.; Williams, D.; Mueller, D.

    2003-01-01

    The purpose of this paper is to present lessons learned from fours years' experience conducting Remedial Investigation and Remedial Action activities at the St. Louis Downtown Site (SLDS) under the Formerly Utilized Sites Remedial Action Program (FUSRAP). Many FUSRAP sites are experiencing challenges conducting Remedial Actions within forecasted volume and budget estimates. The St. Louis FUSRAP lessons learned provide insight to options for cost effective remediation at FUSRAP sites. The lessons learned are focused on project planning (budget and schedule), investigation, design, and construction

  19. HYPNOTEACHING IN HISTORY LESSON

    Directory of Open Access Journals (Sweden)

    Agus Budianto

    2017-07-01

    Full Text Available Abstract: Hypnoteaching in History Lesson. Historical learning is a science that can’t be separated in educating the younger generation. Through this lesson, teachers in secondary schools can provide the foundation of nationality through important events in the study of the social sciences. Many of the problems that occur in learning history, such as the boring and make sleepy. Everyone must have heard the term hypnosis, hypnotism, or hypnotherapy. Each person must also have a different view or understanding when hearing these terms. Hypnoteaching is one of the learning methods by using the art of communicating to influence learners. Hypnoteaching is a combination of five teaching-learning methods such as quantum learning, accelerate learning, power teaching, neuro-linguistic programming (NLP and hypnosis. Hypnoteaching can be done using informal hypnosis as well as formal hypnosis. Informal hypnosis is also called indirect hypnosis ie teachers can naturally make the Critical Area learners become no longer critical, through a very persuasive communication pattern. Here's what the teacher can do in Informal hypnosis: (1 get attention; (2 establishing Themes; (3 presenting the structure and regulations; (4 building relationships. If the learners are already comfortable and interested, the next step is to do a formal hypnosis before the lesson begins. Here are the steps that must be done: (1 Induction; (2 Deepening; (3 Deep level test; (4 Suggestion, and; (5 Termination.   Keywords: Historical learning, hypnoteaching, hypnosis, hypnotism, hypnotherapy, history Abstrak: Hipnoteaching dalam Pembelajaran Sejarah. Pelajaran sejarah tidak bisa dihilangkan dalam mendidik para generasi muda. Melalui pembelajaran ini, guru pada sekolah menengah pertama dapat memberikan pondasi rasa nasionalisme melalui peristiwa peristiwa penting dalam pelajaran ilmu pengetahuan social. Masalah yang sering muncul pada pembelajaran ini adalah kebosanan siswa dan

  20. Higher Education ERP: Lessons Learned.

    Science.gov (United States)

    Swartz, Dave; Orgill, Ken

    2001-01-01

    Shares experiences and lessons learned by chief information officers of large universities about enterprise resource planning (ERP). Specifically, provides a framework for approaching an ERP that could save universities millions of dollars. (EV)

  1. lessons from tuberous sclerosis complex

    African Journals Online (AJOL)

    intellectual disability, autism, specific learning disorders) and mental health disorders (e.g. depression, psychosis and anxiety disorders). The first lesson, therefore, is ... of an adolescent with TSC, facial angiofibromas and a presumed fat-poor ...

  2. Lessons of nuclear power

    International Nuclear Information System (INIS)

    Collingridge, D.

    1984-01-01

    In an earlier article the author has argued that the turbulent history of nuclear power in Britain and the USA stems from the technology itself, and has little to do with the very different institutional arrangements made for the new technology in the two countries. Nuclear plant has various features which make its planning extraordinarily difficult. Its long lead time, large unit size, capital intensity and dependence on complex infrastructure combine to ensure that mistakes are likely to be made in planning the technology and that what mistakes do occur are expensive. This article aims to expand on the earlier one in two ways; by looking at the apparent success of the French nuclear programme which seems to run counter to the thesis of the earlier article, and by trying to draw lessons from the earlier analysis for the breeder reactor. (author)

  3. Lesson "Balance in Nature

    Science.gov (United States)

    Chapanova, V.

    2012-04-01

    Lesson "Balance in Nature" This simulation game-lesson (Balance in Nature) gives an opportunity for the students to show creativity, work independently, and to create models and ideas. It creates future-oriented thought connected to their experience, allowing them to propose solutions for global problems and personal responsibility for their activities. The class is divided in two teams. Each team chooses questions. 1. Question: Pollution in the environment. 2. Question: Care for nature and climate. The teams work on the chosen tasks. They make drafts, notes and formulate their solutions on small pieces of paper, explaining the impact on nature and society. They express their points of view using many different opinions. This generates alternative thoughts and results in creative solutions. With the new knowledge and positive behaviour defined, everybody realizes that they can do something positive towards nature and climate problems and the importance of individuals for solving global problems is evident. Our main goal is to recover the ecological balance, and everybody explains his or her own well-grounded opinions. In this work process the students obtain knowledge, skills and more responsible behaviour. This process, based on his or her own experience, dialogue and teamwork, helps the participant's self-development. Making the model "human↔ nature" expresses how human activities impact the natural Earth and how these impacts in turn affect society. Taking personal responsibility, we can reduce global warming and help the Earth. By helping nature we help ourselves. Teacher: Veselina Boycheva-Chapanova " Saint Patriarch Evtimii" Scholl Str. "Ivan Vazov"-19 Plovdiv Bulgaria

  4. Lessons learned in radiology

    International Nuclear Information System (INIS)

    Goodenough, D.J.

    2001-01-01

    The paper reviews aspects of the history of radiology with the goal of identifying lessons learned, particularly in the area of radiological protection of the patient in diagnostic and interventional radiology, nuclear medicine and radiotherapy. It is pointed out that since the days of Roentgen there has been a need not only to control and quantify the amount of radiation reaching the patient but also to optimize the imaging process to offer the greatest diagnostic benefit within allowable levels of patient dose. To this end, in diagnostic radiology, one finds the development of better films, X rays tubes, grids, screens and processing techniques, while in fluoroscopy, one sees the increased luminance of calcium tungstate. In interventional radiology, one finds an improvement in catheterization techniques and contrast agents. In nuclear medicine, the development of tracer techniques into modern cameras and isotopes such as technetium can be followed. In radiotherapy, one sees the early superficial X rays and radium sources gradually replaced with radon seeds, supervoltage, 60 Co and today's linear accelerators. Along with the incredible advances in imaging and therapeutic technologies comes the growing realization of the potential danger of radiation and the need to protect the patient (as well as physicians, ancillary personnel and the general population) from unnecessary radiation. The important lesson learned is that we must walk a tightrope, balancing the benefits and risks of any technology utilizing radiation to produce the greatest benefits at the lowest acceptable risk. The alternative techniques using non-ionizing radiation will have to be considered as part of the general armamentarium for medical imaging whenever radiation consequences are unacceptable. (author)

  5. Lessons Learned from FUSRAP

    Energy Technology Data Exchange (ETDEWEB)

    Castillo, Darina [U.S. Department of Energy, Office of Legacy Management; Carpenter, Cliff [U.S. Department of Energy, Office of Legacy Management; Miller, Michele [Navarro Research and Engineering

    2016-03-06

    The US DOE Office of Legacy Management (LM) is the long-term steward for 90 sites remediated under numerous regulatory regimes including the Formerly Utilized Sites Remedial Action Program (FUSRAP) sites. In addition, LM holds considerable historical information, gathered in the 1970s, to determine site eligibility for remediation under FUSRAP. To date, 29 FUSRAP sites are in LM’s inventory of sites for long-term surveillance and maintenance (LTS&M), and 25 are with the US Army Corps of Engineers (USACE) for remediation or in the process of being transitioned to LM. It is forecasted that 13 FUSRAP sites will transfer from the USACE to LM over the next 10 years; however, the timing of the transfers is strongly dependent upon federal funding of the ongoing remedial actions. Historically, FUSRAP sites were generally cleaned up for “unrestricted” industrial use or remediated to the “cleanup standards” at that time, and their use remained unchanged. Today, these sites as well as the adjacent properties are now changing or envisioned to have changes in land use, typically from industrial to commercial or residential uses. The implication of land-use change affects DOE’s LTS&M responsibility for the sites under LM stewardship as well as the planning for the additional sites scheduled to transition in time. Coinciding with land-use changes at or near FUSRAP sites is an increased community awareness of these sites. As property development increases near FUSRAP sites, the general public and interested stakeholders regularly inquire about the sufficiency of cleanups that impact their neighborhoods and communities. LM has used this experience to address a series of lessons learned to improve our program management in light of the changing conditions of our sites. We describe these lessons learned as (1) improved stakeholder relations, (2) enhanced LTS&M requirements for the sites, and (3) greater involvement in the transition process.

  6. Lessons learned from accidents investigations

    Energy Technology Data Exchange (ETDEWEB)

    Zuniga-Bello, P. [Consejo Nacional de Ciencia y Tecnologia (CONACYT), Mexico City (Mexico); Croft, J. [National Radiological Protection Board (United Kingdom); Glenn, J

    1997-12-31

    Accidents from three main practices: medical applications, industrial radiography and industrial irradiators are used to illustrate some common causes of accidents and the main lessons to be learned. A brief description of some of these accidents is given. Lessons learned from the described accidents are approached by subjects covering: safety culture, quality assurance, human factors, good engineering practice, defence in depth, security of sources, safety assessment and monitoring and verification compliance. (author)

  7. Lessons learned from accident investigations

    International Nuclear Information System (INIS)

    Zuniga-Bello, P.; Croft, J.R.; Glenn, J.

    1998-01-01

    Accidents in three main practices - medical applications, industrial radiography and industrial irradiators - are used to illustrate some common causes of accidents and the main lessons to be learned from them. A brief description of some of these accidents is given. Lessons learned from the accidents described are approached bearing in mind: safety culture, quality assurance, human factors, good engineering practice, defence in depth, security of sources, safety assessment and monitoring and verification compliance. (author)

  8. Rats bred for helplessness exhibit positive reinforcement learning deficits which are not alleviated by an antidepressant dose of the MAO-B inhibitor deprenyl.

    Science.gov (United States)

    Schulz, Daniela; Henn, Fritz A; Petri, David; Huston, Joseph P

    2016-08-04

    Principles of negative reinforcement learning may play a critical role in the etiology and treatment of depression. We examined the integrity of positive reinforcement learning in congenitally helpless (cH) rats, an animal model of depression, using a random ratio schedule and a devaluation-extinction procedure. Furthermore, we tested whether an antidepressant dose of the monoamine oxidase (MAO)-B inhibitor deprenyl would reverse any deficits in positive reinforcement learning. We found that cH rats (n=9) were impaired in the acquisition of even simple operant contingencies, such as a fixed interval (FI) 20 schedule. cH rats exhibited no apparent deficits in appetite or reward sensitivity. They reacted to the devaluation of food in a manner consistent with a dose-response relationship. Reinforcer motivation as assessed by lever pressing across sessions with progressively decreasing reward probabilities was highest in congenitally non-helpless (cNH, n=10) rats as long as the reward probabilities remained relatively high. cNH compared to wild-type (n=10) rats were also more resistant to extinction across sessions. Compared to saline (n=5), deprenyl (n=5) reduced the duration of immobility of cH rats in the forced swimming test, indicative of antidepressant effects, but did not restore any deficits in the acquisition of a FI 20 schedule. We conclude that positive reinforcement learning was impaired in rats bred for helplessness, possibly due to motivational impairments but not deficits in reward sensitivity, and that deprenyl exerted antidepressant effects but did not reverse the deficits in positive reinforcement learning. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

  9. Evaluating the Effect of Rainfall Infiltration on the Slope Stability of T16 tower of Taipei Mao-kong Gondola by Numerical Methods

    Science.gov (United States)

    RUNG, J.

    2013-12-01

    In this study, a series of rainfall-stability analyses were performed to simulate the failure mechanism and the function of remediation works of the down slope of T-16 tower pier, Mao-Kong gondola (or T-16 Slope) at the hillside of Taipei City using two-dimensional finite element method. The failure mechanism of T-16 Slope was simulated using the rainfall hyetograph of Jang-Mi typhoon in 2008 based on the field investigation data, monitoring data, soil/rock mechanical testing data and detail design plots of remediation works. Eventually, the numerical procedures and various input parameters in the analysis were verified by comparing the numerical results with the field observations. In addition, 48 hrs design rainfalls corresponding to 5, 10, 25 and 50 years return periods were prepared using the 20 years rainfall data of Mu-Zha rainfall observation station, Central Weather Bureau for the rainfall-stability analyses of T-16 Slope to inspect the effect of the compound stabilization works on the overall stability of the slope. At T-16 Slope, without considering the longitudinal and transverse drainages on the ground surface, there totally 4 types of stabilization works were installed to stabilize the slope. From the slope top to the slope toe, the stabilization works of T-16 Slope consists of RC-retaining wall with micro-pile foundation at the up-segment, earth anchor at the up-middle-segment, soil nailing at the middle-segment and retaining pile at the down-segment of the slope. The effect of each individual stabilization work on the slope stability under rainfall condition was examined and evaluated by raising field groundwater level.

  10. Applying dam height-storage curve to geomorphic features analysis within virtual geographic environment: a case study of the Hong-Shi-Mao watershed

    Science.gov (United States)

    Wang, Daojun; Gong, Jianhua; Ma, Ainai; Li, Wenhang; Wang, Xijun

    2005-10-01

    There are generally two kinds of approaches to studying geomorphic features in terms of the quantification level and difference of major considerations. One is the earlier qualitative characterization, and the other is the 2-dimension measurement that includes section pattern and projection pattern. With the development of geo-information technology, especially the 3-D geo-visualization and virtual geographic environments (VGE), 3-dimension measurement and dynamic interactive between users and geo-data/geo-graphics can be developed to understand geomorphic features deeply, and to benefit to the effective applications of such features for geographic projects like dam construction. Storage-elevation curve is very useful for site selection of projects and flood dispatching in water conservancy region, but it is just a tool querying one value from the other one. In fact, storage-elevation curve can represent comprehensively the geomorphic features including vertical section, cross section of the stream and the landform nearby. In this paper, we use quadratic regression equation shaped like y = ax2 + bx + c and the DEM data of Hong-Shi-Mao watershed, Zi Chang County, ShaanXi Province, China to find out the relationship between the coefficients of the equation and the geomorphic features based on VGE platform. It's exciting that the coefficient "a" appear to be correlative strongly with the stream scale, and the coefficient "b" may give an index to the valley shape. In the end, we use a sub-basin named Hao-Jia-Gou of the watershed as an application. The result of correlative research about quadratic regression equation and geomorphic features can save computing and improve the efficiency in silt dam systems planning.

  11. Supporting teachers' technology integration in lesson plans

    NARCIS (Netherlands)

    Janssen, Noortje

    2017-01-01

    Lesson planning offers rich opportunities for teachers to consider and implement technology in the classroom. This dissertation investigated the design and effectiveness of supplementary information to assist pre-service teachers during the lesson planning process. Based on the Technological,

  12. Value pricing pilot program : lessons learned

    Science.gov (United States)

    2008-08-01

    This "Lessons Learned Report" provides a summary of projects sponsored by the Federal Highway Administration's (FHWA's) Congestion and Value Pricing Pilot Programs from 1991 through 2006 and draws lessons from a sample of projects with the richest an...

  13. Lessons from independence

    International Nuclear Information System (INIS)

    Hauptfuhrer, R.R.

    1990-01-01

    The recent history of Oryx provides invaluable lessons for those who plan future energy strategies, relates the author of this paper. When Oryx became an independent oil and gas company, its reserves were declining, its stock was selling below asset values, and the price of oil seemed stuck below $15 per barrel. The message from Oryx management to Oryx employees was: We are in charge of our own destiny. We are about to create our own future. Oryx had developed a new, positive corporate culture and the corporate credit required for growth. This paper points to two basic principles that have guided the metamorphosis in Oryx's performance. The first objective was to improve operational efficiency and to identify the right performance indicators to measure this improvement. It states that the most critical performance indicator for an exploration and production company must be replacement and expansion of reserves at a competitive replacement cost. Oryx has cut its finding costs from $12 to $5 per barrel, while the BP acquisition provided proven reserves at a cost of only $4 per barrel. Another performance indicator measures Oryx's standing in the financial markets

  14. Patient safety: lessons learned

    International Nuclear Information System (INIS)

    Bagian, James P.

    2006-01-01

    The traditional approach to patient safety in health care has ranged from reticence to outward denial of serious flaws. This undermines the otherwise remarkable advances in technology and information that have characterized the specialty of medical practice. In addition, lessons learned in industries outside health care, such as in aviation, provide opportunities for improvements that successfully reduce mishaps and errors while maintaining a standard of excellence. This is precisely the call in medicine prompted by the 1999 Institute of Medicine report ''To Err Is Human: Building a Safer Health System.'' However, to effect these changes, key components of a successful safety system must include: (1) communication, (2) a shift from a posture of reliance on human infallibility (hence ''shame and blame'') to checklists that recognize the contribution of the system and account for human limitations, and (3) a cultivation of non-punitive open and/or de-identified/anonymous reporting of safety concerns, including close calls, in addition to adverse events. (orig.)

  15. Constellation Program Lessons Learned. Volume 2; Detailed Lessons Learned

    Science.gov (United States)

    Rhatigan, Jennifer; Neubek, Deborah J.; Thomas, L. Dale

    2011-01-01

    These lessons learned are part of a suite of hardware, software, test results, designs, knowledge base, and documentation that comprises the legacy of the Constellation Program. The context, summary information, and lessons learned are presented in a factual format, as known and described at the time. While our opinions might be discernable in the context, we have avoided all but factually sustainable statements. Statements should not be viewed as being either positive or negative; their value lies in what we did and what we learned that is worthy of passing on. The lessons include both "dos" and "don ts." In many cases, one person s "do" can be viewed as another person s "don t"; therefore, we have attempted to capture both perspectives when applicable and useful. While Volume I summarizes the views of those who managed the program, this Volume II encompasses the views at the working level, describing how the program challenges manifested in day-to-day activities. Here we see themes that were perhaps hinted at, but not completely addressed, in Volume I: unintended consequences of policies that worked well at higher levels but lacked proper implementation at the working level; long-term effects of the "generation gap" in human space flight development, the need to demonstrate early successes at the expense of thorough planning, and the consequences of problems and challenges not yet addressed because other problems and challenges were more immediate or manifest. Not all lessons learned have the benefit of being operationally vetted, since the program was cancelled shortly after Preliminary Design Review. We avoid making statements about operational consequences (with the exception of testing and test flights that did occur), but we do attempt to provide insight into how operational thinking influenced design and testing. The lessons have been formatted with a description, along with supporting information, a succinct statement of the lesson learned, and

  16. What Happens at the Lesson Start?

    Science.gov (United States)

    Saloviita, Timo

    2016-01-01

    Transitional periods, such as lesson starts, are necessary steps from one activity to another, but they also compete with time for actual learning. The aim of the present study was to replicate a previous pilot study on lesson starts and explore possible disturbances. In total, 130 lesson starts in Finnish basic education in grades 1-9 were…

  17. Lessons of nuclear robot history

    International Nuclear Information System (INIS)

    Oomichi, Takeo

    2014-01-01

    Severe accidents occurred at Fukushima Daiichi Nuclear Power Station stirred up people's great expectation of nuclear robot's deployment. However unexpected nuclear disaster, especially rupture of reactor building caused by core meltdown and hydrogen explosion, made it quite difficult to introduce nuclear robot under high radiation environment to cease accidents and dispose damaged reactor. Robotics Society of Japan (RSJ) set up committee to look back upon lessons learned from 50 year's past experience of nuclear robot development and summarized 'Lessons of nuclear robot history', which was shown on the home page website of RSJ. This article outlined it with personal comment. History of nuclear robot developed for inspection and maintenance at normal operation and for specific required response at nuclear accidents was reviewed with many examples at home and abroad for TMI, Chernobyl and JCO accidents. Present state of Fukushima accident response robot's introduction and development was also described with some comments on nuclear robot development from academia based on lessons. (T. Tanaka)

  18. Overview of lessons learnt

    International Nuclear Information System (INIS)

    Pescatore, C.; Federline, M.; Duncan, A.

    2004-01-01

    During the Tarragona International Seminar the participating high-level specialists had very open and fruitful discussion concerning strategic decommissioning issues. The lessons learnt and possible solutions for future work issues can be found below. Although there appears to be a trend towards early dismantling, there seemed to be general agreement that technical solutions support a wide variety of safe decommissioning approaches. Thus, in terms of decommissioning strategy, it appears that no one size fits all. A flexible regulatory approach is needed in order to recognize the changing operational risks and physical conditions of facilities with time, and to optimise their dismantling. The NEA has released a comprehensive study on decommissioning strategies and costs that indicates world-wide progress. According to this report, over 50% of countries with nuclear facilities have a framework of decommissioning requirements and 60% have defined radioactive waste clearance levels. Up to about 70% of the costs of D and D are attributable to dismantling and waste management. The provisions for safety of the D and D process are closely linked to the availability of the necessary funds as and when required. A number of common factors were defined for successful implementation of decommissioning strategies: i.e. safety, technical feasibility of decommissioning options, risk-informed progression of D and D activities as project proceeds, maintenance of competency and corporate memory throughout project, waste management and disposal capability, financing that suits the scope of the project, a well-defined risk-informed and performance-based regulatory process, and establishment of effective communication with local and regional governments and key stakeholders, particularly personnel, at the earliest opportunity before decommissioning. (author)

  19. [Economics] Introductory Lesson (Begin Day One). Lesson Plan.

    Science.gov (United States)

    Lewin, Roland

    This introductory lesson on teaching economics concepts contains sections on the following: purpose; objectives; time; materials needed; and step-by-step classroom procedures. The focus is on the economic problem of scarcity and opportunity costs. Attached is an original skit, "There's no such thing as a free lunch," and a chart that…

  20. Lessons learned related to packaging and transportation

    International Nuclear Information System (INIS)

    Wallen, C.

    1995-01-01

    The use of lessons learned as a tool for learning from past experiences is well established, especially by many organizations within the nuclear industry. Every person has, at some time, used the principles of lessons learned to adopt good work practices based on their own experiences or the experiences of others. Lessons learned can also help to avoid the recurrence of adverse practices, which is often an area that most lessons-learned programs tend to focus on. This paper will discuss how lessons learned relate to packaging and transportation issues and events experienced at Department of Energy (DOE) facilities. It will also discuss the role performed by the Office of Nuclear and Facility Safety's Office of Operating Experience Analysis and Feedback in disseminating lessons learned and operating experience feedback to the DOE complex. The central concept of lessons learned is that any organization should be able to learn from its own experiences and events. In addition, organizations should implement methodologies to scan external environments for lessons learned, to analyze and determine the relevance of lessons learned, and to bring about the necessary changes learned from these experiences. With increased concerns toward facility safety, the importance of utilizing the lessons-learned principles and the establishment of lessons-learned programs can not be overstated

  1. Field observations and lessons learned

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Joh B [Los Alamos National Laboratory

    2010-01-01

    This presentation outlines observations and lessons learned from the Megaports program. It provides: (1) details of field and technical observations collected during LANL field activities at ports around the world and details of observations collected during radiation detections system testing at Los Alamos National Laboratory; (2) provides suggestions for improvement and efficiency; and (3) discusses possible program execution changes for more effective operations.

  2. For Sale: Your Lesson Plans

    Science.gov (United States)

    Greene, Kim

    2016-01-01

    The last several years has seen an increasingly popular trend of teachers buying and selling their lesson plans and other self-created classroom materials in online marketplaces. The leader in this space is a website called Teachers Pay Teachers, which boasts 3.8 million active users. In this article, the author examines why these sites became…

  3. Children of War. [Lesson Plan].

    Science.gov (United States)

    Discovery Communications, Inc., Bethesda, MD.

    This lesson plan presents activities in which students read, analyze, and discuss excerpts from children's war diaries; and create a storyboard for a public service announcement on children's rights in wartime. It includes objectives, materials, procedures, extension activities, excerpts of children's war diaries, suggested readings, and web…

  4. Lessons learned in crisis management.

    Science.gov (United States)

    Olson, Chris

    2014-01-01

    This paper will explore lessons learned following a series of natural and man-made disasters affecting the Massachusetts Mutual Life Insurance Company and/or its subsidiaries. The company employs a team of certified continuity professionals who are charged with overseeing resilience on behalf of the enterprise and leading recovery activities wherever and whenever necessary.

  5. "Pride and Prejudice". [Lesson Plan].

    Science.gov (United States)

    Soderquist, Alisa

    Based on Jane Austen's novel "Pride and Prejudice," this lesson plan presents activities designed to help students understand that classics are those pieces of literature that continue to be popular long after they were written; classics tend to have universal themes; and Austen's writing has been updated and dramatized and, most likely, will…

  6. Machiavelli's "The Prince." [Lesson Plan].

    Science.gov (United States)

    Discovery Communications, Inc., Bethesda, MD.

    Based on Machiavelli's book "The Prince," this lesson plan presents activities designed to help students understand that Machiavelli's enumeration of leadership qualities for a prince has always been controversial; and that leaders and followers may differ in what they identify as the qualities of a good leader. The main activity of the lesson…

  7. Basic safety principles: Lessons learned

    Energy Technology Data Exchange (ETDEWEB)

    Erp, J.B. van [Argonne National Lab., IL (United States)

    1997-09-01

    The presentation reviews the following issues: basic safety principles and lessons learned; some conclusions from the Kemeny report on the accident at TMI; some recommendations from the Kemeny report on the accident at TMI; conclusions and recommendations from the Rogovin report on the accident on TMI; instrumentation deficiencies (from Rogovin report).

  8. Lessons from The Little Prince

    Science.gov (United States)

    Munakata, Mika

    2005-01-01

    To children, The Little Prince by Antoine de Saint-Exupery (1943) may be a mystical story about a traveler among planets. For adults, the story can be appreciated for the lessons it teaches us about what it is like to be a child--and how children may perceive the world of adults. And, for science educators, particularly, The Little Prince…

  9. Basic safety principles: Lessons learned

    International Nuclear Information System (INIS)

    Erp, J.B. van

    1997-01-01

    The presentation reviews the following issues: basic safety principles and lessons learned; some conclusions from the Kemeny report on the accident at TMI; some recommendations from the Kemeny report on the accident at TMI; conclusions and recommendations from the Rogovin report on the accident on TMI; instrumentation deficiencies (from Rogovin report)

  10. The 'Amistad' Case. Lesson Plan.

    Science.gov (United States)

    National Archives and Records Administration, Washington, DC.

    Teaching about the Amistad case provides correlations to the National Standards for History, and Civics and Government. An overview of the events of 1839 is given in this lesson plan. Seven student activities include reading and using primary source documents, writing journal articles, viewing the movie "Amistad," and giving…

  11. Evaluating Eyewitness Reports [Lesson Plan].

    Science.gov (United States)

    2000

    This lesson offers students experience in making historical meaning from eyewitness accounts that present a range of different perspectives. Students begin with a case study in working with alternative reports of a single event: the Great Chicago Fire of 1871. First, they compare two newspaper reports on the fire, then two memoirs of the fire…

  12. Lessons in Contingent, Recursive Humility

    Science.gov (United States)

    Vagle, Mark D.

    2011-01-01

    In this article, the author argues that critical work in teacher education should begin with teacher educators turning a critical eye on their own practices. The author uses Lesko's conception of contingent, recursive growth and change to analyze a lesson he observed as part of a phenomenological study aimed at understanding more about what it is…

  13. The Great Gatsby. [Lesson Plan].

    Science.gov (United States)

    Zelasko, Ken

    Based on F. Scott Fitzgerald's novel "The Great Gatsby," this lesson plan presents activities designed to help students understand that adapting part of a novel into a dramatic reading makes students more intimate with the author's intentions and craft; and that a part of a novel may lend itself to various oral interpretations. The main activity…

  14. Charismatic Leaders: A Lesson Plan.

    Science.gov (United States)

    Johns, Robert W.

    1983-01-01

    Focusing upon Franklin D. Roosevelt and Adolf Hitler, these lessons for high school students in U.S. or world history courses deal with what charismatic leadership is, what circumstances and personality factors generate charismatic movements, and the role, results, and dangers of charismatic leadership. (RM)

  15. Multimedia Principle in Teaching Lessons

    Science.gov (United States)

    Kari Jabbour, Khayrazad

    2012-01-01

    Multimedia learning principle occurs when we create mental representations from combining text and relevant graphics into lessons. This article discusses the learning advantages that result from adding multimedia learning principle into instructions; and how to select graphics that support learning. There is a balance that instructional designers…

  16. Constellation Lessons Learned Executive Summary

    Science.gov (United States)

    Thomas, L. Dale; Neubek, Deb

    2011-01-01

    This slide presentation reviews the lessons learned from the Constellation Program (CxP) and identified several factors that contributed to the inability of the CxP to meet the cost and schedule commitments. The review includes a significant section on the context in which the CxP operated since new programs are likely to experience the same constraints.

  17. EMU Lessons Learned Database

    Science.gov (United States)

    Matthews, Kevin M., Jr.; Crocker, Lori; Cupples, J. Scott

    2011-01-01

    As manned space exploration takes on the task of traveling beyond low Earth orbit, many problems arise that must be solved in order to make the journey possible. One major task is protecting humans from the harsh space environment. The current method of protecting astronauts during Extravehicular Activity (EVA) is through use of the specially designed Extravehicular Mobility Unit (EMU). As more rigorous EVA conditions need to be endured at new destinations, the suit will need to be tailored and improved in order to accommodate the astronaut. The Objective behind the EMU Lessons Learned Database(LLD) is to be able to create a tool which will assist in the development of next-generation EMUs, along with maintenance and improvement of the current EMU, by compiling data from Failure Investigation and Analysis Reports (FIARs) which have information on past suit failures. FIARs use a system of codes that give more information on the aspects of the failure, but if one is unfamiliar with the EMU they will be unable to decipher the information. A goal of the EMU LLD is to not only compile the information, but to present it in a user-friendly, organized, searchable database accessible to all familiarity levels with the EMU; both newcomers and veterans alike. The EMU LLD originally started as an Excel database, which allowed easy navigation and analysis of the data through pivot charts. Creating an entry requires access to the Problem Reporting And Corrective Action database (PRACA), which contains the original FIAR data for all hardware. FIAR data are then transferred to, defined, and formatted in the LLD. Work is being done to create a web-based version of the LLD in order to increase accessibility to all of Johnson Space Center (JSC), which includes converting entries from Excel to the HTML format. FIARs related to the EMU have been completed in the Excel version, and now focus has shifted to expanding FIAR data in the LLD to include EVA tools and support hardware such as

  18. UNLEARNED LESSONS OF CONTEMPORARY HISTORY

    Directory of Open Access Journals (Sweden)

    А Н Данилов

    2017-12-01

    Full Text Available The article considers the complex geopolitical situation in the global world at the end of the second decade of the 21st century as determined by the consequences of the collapse of the Soviet Union and by the new world order. The author seeks to answer the questions who will define the current geopolitical situation, whose aims it will reflect, what will become the basis of new geopolitical realities, the basis of moral solidarity of humankind, and the spiritual basis of future civilizations. The new challenges give rise to a desperate struggle for different scenarios for building a happy life. Moreover, it is not clear which ideal of the future world will be widely supported as a development guideline. The recognition as such of the standard of living and development of the strongest ones becomes a real threat to the new civilization for it leads to the loss of national interests of sovereign states, and to the loss of an independent future. Today, there is an active search for new theories and concepts that will adequately explain con-temporary global processes. In this thematic context, the author identifies main lessons not learned by the world political elites. The first lesson: new states are not born in an empty place, their common history is a great advantage ensuring prospects for the further development of interstate cooperation. The second lesson: the widespread falsification of history has a negative impact on national, cultural and social-group identity in transforming societies. The third lesson: after the collapse of the Soviet Union, the post-war balance of power was destroyed together with the system of checks and balances in world politics (a bipolar model of the world. The fourth lesson: under radical social transformations, the moral system of the population devaluates with numerous crisis consequences.

  19. The individual teacher in lesson study collaboration

    DEFF Research Database (Denmark)

    Skott, Charlotte Krog; Møller, Hanne

    2017-01-01

    used in lesson study research. Design/methodology/approach The authors use collective case studies. By being participant observers the authors provide detailed descriptions of two selected teachers’ lived experiences of lesson study collaboration. In addition to gain first-hand insights, the authors...... in the participation of each of the two teachers during a two-year lesson study project. By comparing these shifts the authors identify significant conditions for their individual learning. Research limitations/implications Although the study is small scale, both the insights into the different ways in which teachers...... participated and the theoretical insights might be valuable for other lesson study research approaches. Practical implications This paper provides valuable insights into conditions that might influence teachers’ participation in lesson study activities, especially in cultures with little experience of lesson...

  20. The Employed Neurosurgeon: Essential Lessons.

    Science.gov (United States)

    Benzil, Deborah L; Zusman, Edie E

    2017-04-01

    Neurosurgeons are highly specialized surgeons whose pride is mastery of the complexity of form and function that is the nervous system and then knowing when and how these require surgical intervention. Following years of arduous postgraduate education, neurosurgeons enter the world of practice that is not only daunting in its intricacies of regulations, mandates, and unknown business practices, but also changing at a meteoric pace. Overwhelmingly, graduating residents and fellows are choosing to practice as employed physicians, a trend that is new in its magnitude and also changed because of the rapid evolution of large health systems. Case studies of challenges other employed surgical specialists have faced can provide critical and important education for any neurosurgeon in this arena. As with the lessons of all case studies, the teachings are remarkably universal, but how those lessons apply to an individual's specific situation will require personalized adaptation. Copyright © 2016 by the Congress of Neurological Surgeons.

  1. USING LITERATURE IN GEOGRAPHY LESSONS

    Directory of Open Access Journals (Sweden)

    ROXANA HOBAI

    2015-01-01

    Full Text Available Including in a novel information about relief, climate, vegetation, fauna and various aspects of socio-economic life can make literature a real source of geographical information. Using realistic literary works in Geography lessons has multiple benefits, which are not limited only to geographical knowledge. In this paper there are some fragments from literature, suggestions of activities about how to integrate the fragments during Geography lessons and the results of these activities. The activities are from fifth to twelfth grade, passing through a first example of water pollution resulting from a Hercules labour, through the lyricism of the aurora borealis description, through the dramatic life of a refugee from Darfur, through the Dobrudgea winter landscape, through the grey urban landscape of Bucharest in the 90s and so on. Students were put into learning situations that stimulated their creativity, developed communication competencies and enriched their general knowledge.

  2. 延安时期毛泽东关于民生问题的理论和实践探索%Mao Zedong's Theory and Practice on Livelihood Issues during the Yan'an Period

    Institute of Scientific and Technical Information of China (English)

    吴毅君; 张志兵; 韩平

    2014-01-01

    During the Yan'an period,based on the actual reality of the warfare and the border area,Mao Zedong proposed a series of important theories on solving the livelihood issues by developing democracy,econ-omy,cultural education and social security,etc.Mao Zedong also proposed practices and countermeasures in carrying out democracy,developing production,setting up education undertakings,and helping the poor, which had solved the most direct and the most realistic interest that common people were very much concerned about.Inspecting Mao Zedong's theory and practice on livelihood issues during this period,we should fully un-derstand that democracy is the guarantee,development is the premise,and education is the cornerstone to solve the livelihood issues,and social security is a basic system to protect people's life and regulate social dis-tribution.It is of importantly guiding significance and referential value for the currently overall social construc-tion led by the Chinese Communist Party with the focus on improving the livelihood.%延安时期,针对战争环境和边区实际,毛泽东提出了通过实行民主、发展经济、文化教育以及社会保障等一系列关于解决民生问题的重要理论,并通过推行民主、发展生产、兴办教育、扶贫济困等实践举措,改善了民众最关心最直接最现实的利益问题,积累了丰富的关于民生问题的理论和实践经验。考察这一时期毛泽东的民生理论和实践探索,充分认识民主是解决民生问题的保证、发展是解决民生问题的前提、教育是解决民生问题的基石和社会保障是保障人民生活、调节社会分配的一项基本制度,这对于当前中国共产党全面开展以改善民生为重点的社会建设具有十分重要的指导意义和参考价值。

  3. Brentwood Lessons Learned Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Rivkin, Carl H. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Caton, Melanie C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ainscough, Christopher D. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Marcinkoski, Jason [Dept. of Energy (DOE), Washington DC (United States)

    2017-09-26

    The purpose of this report is to document lessons learned in the installation of the hydrogen fueling station at the National Park Service Brentwood site in Washington, D.C., to help further the deployment of hydrogen infrastructure required to support hydrogen and other fuel cell technologies. Hydrogen fueling is the most difficult infrastructure component to build and permit. Hydrogen fueling can include augmenting hydrogen fueling capability to existing conventional fuel fueling stations as well as building brand new hydrogen fueling stations. This report was produced as part of the Brentwood Lessons Learned project. The project consisted of transplanting an existing modular hydrogen fueling station from Connecticut to the National Park Service Brentwood site. This relocation required design and construction at the Brentwood site to accommodate the existing station design as well as installation and validation of the updated station. One of the most important lessons learned was that simply moving an existing modular station to an operating site was not necessarily straight-forward - performing the relocation required significant effort and cost. The station has to function at the selected operating site and this functionality requires a power supply, building supports connecting to an existing alarm system, electrical grounding and lighting, providing nitrogen for purging, and providing deionized water if an electrolyzer is part of the station package. Most importantly, the station has to fit into the existing site both spatially and operationally and not disrupt existing operations at the site. All of this coordination and integration requires logistical planning and project management. The idea that a hydrogen fueling station can be simply dropped onto a site and made immediately operational is generally not realistic. Other important lessons learned include that delineating the boundaries of the multiple jurisdictions that have authority over a project for

  4. Children's Satisfaction with Private Music Lessons.

    Science.gov (United States)

    Rife, Nora A.; Shnek, Zachary M.; Lauby, Jennifer L.; Lapidus, Leah Blumberg

    2001-01-01

    Determines the language children use to express their feelings of satisfaction with private music lessons. Offers a list of statements from children about private music lessons to be used to assess those feelings. Discusses the effects of age, gender, and musical instruments on satisfaction for music educators. Includes references. (DAJ)

  5. Pacemaker Primary Curriculum; Lesson Book Level B.

    Science.gov (United States)

    Ross, Dorothea M.; Ross, Sheila A.

    This lesson book, which is the second in a four-level program for young children with learning difficulties, describes the purpose of and equipment and procedures for teaching lessons in the following subjects areas on the primary grade level: arithmetic, reading, vocabulary, listening, planning, problem solving, social behavior, art, music, and…

  6. Pacemaker Primary Curriculum; Lesson Book Level A.

    Science.gov (United States)

    Ross, Dorothea M.; Ross, Sheila A.

    This lesson book, which is the first in a four-level program for young children with learning difficulties, describes the purpose of and equipment and procedures for teaching lessons in the following subject areas on the kindergarten level: arithmetic concepts, number concepts, reading readiness, vocabulary, language, listening, social behavior,…

  7. Pacemaker Primary Curriculum; Lesson Book Level C.

    Science.gov (United States)

    Ross, Dorothea M.; Ross, Sheila A.

    This lesson book, which is the third in a four-level program for young children with learning difficulties, describes the purpose of and equipment and procedures for teaching lessons in the following subject areas on the primary grade level: arithmetic, reading, vocabulary, spelling, printing, listening, planning, problem solving, social behavior,…

  8. Pacemaker Primary Curriculum; Lesson Book Level D.

    Science.gov (United States)

    Ross, Dorothea M.; Ross, Sheila A.

    This lesson book, which is the last in a four-level program for young children with learning difficulties, describes the purpose of and equipment and procedures for teaching lessons in the following subject areas on the primary level: arithmetic, reading, vocabulary, spelling, printing, listening, planning and problem solving, social behavior,…

  9. Lesson Planning with the Common Core

    Science.gov (United States)

    Estes, Linda A.; McDuffie, Amy Roth; Tate, Cathie

    2014-01-01

    Planning a lesson can be similar to planning a road trip--a metaphor the authors use to describe how they applied research and theory to their lesson planning process. A map and mode of transportation, the Common Core State Standards for Mathematics (CCSSM) and textbooks as resources, can lead to desired destinations, such as students engaging in…

  10. Leadership in American Indian Communities: Winter Lessons

    Science.gov (United States)

    Metoyer, Cheryl A.

    2010-01-01

    Winter lessons, or stories told in the winter, were one of the ways in which tribal elders instructed and directed young men and women in the proper ways to assume leadership responsibilities. Winter lessons stressed the appropriate relationship between the leader and the community. The intent was to remember the power and purpose of that…

  11. Professor's Page: Do Demonstration Lessons Work?

    Science.gov (United States)

    Clarke, Doug

    2011-01-01

    As part of a large research and professional development project funded by the Catholic Education Office Melbourne (CEOM), called "Contemporary Teaching and Learning of Mathematics," the ACU team has been leading demonstration lessons. There is certainly not universal agreement on the worth of demonstration lessons in the mathematics…

  12. Human Spaceflight Conjunction Assessment: Lessons Learned

    Science.gov (United States)

    Smith, Jason T.

    2011-01-01

    This viewgraph presentation reviews the process of a human space flight conjunction assessment and lessons learned from the more than twelve years of International Space Station (ISS) operations. Also, the application of these lessons learned to a recent ISS conjunction assessment with object 84180 on July 16, 2009 is also presented.

  13. Physically active academic lessons in elementary children.

    Science.gov (United States)

    Bartholomew, John B; Jowers, Esbelle M

    2011-06-01

    Although schools are an ideal location to conduct interventions that target children, the emphasis on standardized testing makes it difficult to implement interventions that do not directly support academic instruction. In response, physically active academic lessons have been developed as a strategy to increase physical activity while also addressing core educational goals. Texas I-CAN! is one incarnation of this approach. We will review the on-going research on the impact of these active lessons on: teacher implementation, child step count, child attention control, and academic performance. The collected studies support the impact of physically active academic lessons on each area of interest. If these data can be replicated, it suggests that teachers might find these lessons of benefit to their primary role as educators, which should ease dissemination of these and other physically active lessons in elementary schools. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. Esiterroristi perekonna mitu palet - kurikuulsa sugulase tume vari / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2008-01-01

    Osama bin Ladeni elust ja perekonnast. Vt. samas Osama vennatütar laulab ja poseerib Ameerika ajakirjadele; Osama poeg tahab Briti alamaks saada. Lisad: Suguselts; Osama bin Laden; Aafriklanna oli Osama seksiori

  15. A Relevant Lesson: Hitler Goes to the Mall

    Science.gov (United States)

    Gerwin, David

    2003-01-01

    A "Motivation" eliciting the "Aim" of each lesson initiates each lesson in the orthodox "developmental lesson-plan" that has dominated classroom instruction in NYC public schools for at least the past half-century. An action-research study of 38 lesson-plans (over 5 each from 5 teachers) drawn from student-teaching…

  16. Improving Mathematics Teaching as Deliberate Practice through Chinese Lesson Study

    Science.gov (United States)

    Huang, Rongjin; Prince, Kyle M.; Barlow, Angela T.

    2017-01-01

    This study examined how a ninth grade teacher improved an Algebra I lesson through a lesson study approach. We used multiple data sources to investigate the improvement of the lesson towards student-centered mathematics instruction, perceived benefits of the teacher, and factors associated with the improvement of teaching. The lesson group…

  17. Chernobyl: lessons of the decade

    International Nuclear Information System (INIS)

    Tsaregorodtsev, A.D.

    1996-01-01

    The Chernobyl accident led to a drastic increase the incidents of thyroid cancer in children living at territories contaminated with radionuclides. The incidents of hemoblastoses which are etiologically closely related to radiation did not change after the incident. The lessons of the decade that passed since the accident necessitate measures aimed at alleviation of the medical consequences of the accident which are to be implemented for many years. The program of such measures should be based on a strictly scientific evaluation of each factor, that will be conductive to a most adequate state financing of this work [ru

  18. Southwest Airlines: lessons in loyalty.

    Science.gov (United States)

    D'Aurizio, Patricia

    2008-01-01

    Southwest Airlines continues to garner accolades in the areas of customer service, workforce management, and profitability. Since both the health care and airlines industries deal with a service rather than a product, the customer experience depends on the people who deliver that experience. Employees' commitment or "loyalty" to their customers, their employer, and their work translates into millions of dollars of revenue. What employee wants to work for "the worst employer in town?" Nine loyalty lessons from Southwest can be carried over to the health care setting for the benefit of employees and patients.

  19. Implementing US Department of Energy lessons learned programs. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    The DOE Lessons Learned Handbook is a two-volume publication developed to supplement the DOE Lessons Learned Standard (DOE-STD-7501-95) with information that will organizations in developing or improving their lessons learned programs. Volume 1 includes greater detail than the Standard in areas such as identification and documentation of lessons learned; it also contains sections on specific processes such as training and performance measurement. Volume 2 (this document) contains examples of program documents developed by existing lessons learned programs as well as communications material, functional categories, transmittal documents, sources of professional and industry lessons learned, and frequently asked questions about the Lessons Learned List Service.

  20. Intergenerational Lessons and 'Fabulous Stories'.

    Science.gov (United States)

    Lewenson, Sandra B; Welch, Cathryne A; Hassmiller, Susan B

    2015-10-01

    While directing the Future of Nursing: Campaign for Action, Susan B. Hassmiller, the Robert Wood Johnson Foundation's senior adviser for nursing, realized the value that nursing history could bring to the campaign. She decided to interview her mother, Jacqueline J. Wouwenberg, a 1947 graduate of the Bellevue Hospital School of Nursing, in order to better understand and contextualize changes that had occurred in the nursing profession during the 20th century. In collaboration with nurse historians Cathryne A. Welch and Sandra B. Lewenson, Hassmiller participated in interviewing her mother and was also interviewed herself. The stories that emerged revealed a great deal: each woman had found that nursing had given them countless opportunities that reflected the time periods in which they lived. Wouwenberg's experiences, transmitted to Hassmiller through words and actions, also served as important lessons for her daughter. This article shares five lessons: be independent and courageous, know that nursing has no bounds, follow your passion, honor diversity, and give back. It also asks readers to reflect on the relevance of nurses' work from one generation to the next..

  1. Lessons Learned for Decommissioning Planning

    International Nuclear Information System (INIS)

    Sohn, Wook; Kim, Young-gook; Kim, Hee-keun

    2015-01-01

    The purpose of this paper is to introduce the U.S. nuclear industrial's some key lessons learned especially for decommissioning planning based on which well informed decommissioning planning can be carried out. For a successful decommissioning, it is crucial to carry out a well-organized decommissioning planning before the decommissioning starts. This paper discussed four key factors which should be decided or considered carefully during the decommissioning planning period with introduction of related decommissioning lessons learned of U.S. nuclear industry. Those factors which have been discussed in this paper include the end state of a site, the overall decommissioning strategy, the management of the spent fuels, and the spent fuel pool island. Among them, the end state of a site should be decided first as it directs the whole decommissioning processes. Then, decisions on the overall decommissioning strategy (DECON vs. SAFSTOR) and the management of the spent fuels (wet vs. dry) should follow. Finally, the spent fuel pool island should be given due consideration because its implementation will result in much cost saving. Hopefully, the results of this paper would provide useful inputs to performing the decommissioning planing for the Kori unit 1

  2. Alternative Energy Lessons in Scotland

    Science.gov (United States)

    Boyle, Julie

    2010-05-01

    In Scotland the new science curriculum for pupils aged 12 to 15 shall include the following outcomes: "Using my knowledge and understanding, I can express an informed view on a national or global environmental issue;" "I have participated in constructing a model to harness a renewable source of energy and can investigate how to optimise the output;" and "I can discuss why it is important to me and to the future of the world that alternatives to fossil fuels are developed." There will be an emphasis on creating lessons that will nurture responsible citizens, improve pupil engagement and allow students to develop their team working skills. To help teachers plan lessons to address this, the Scottish Schools Equipment Research Centre and Edinburgh University made teaching materials on four renewable energy resources. This poster describes how their suggested activities on solar cells, wind turbines, hydroelectric power stations and wave power were used in science lessons with twelve year old students. After an initial class discussion based on issues related to climate change and diminishing fossil fuel supplies, a workshop activity was carried out in three stages. The students were issued with a fact sheet about one of four imaginary islands (Skisdale, Cloudy Island, Surfsville and Sun City) and they were asked to work in teams to choose the most suitable method of generating electricity for their island. Issues such as costs, where it will be sited and environmental implications were considered. They were then asked to conduct practical activities by constructing and testing models for these forms of renewable energy. To conclude, they presented their proposal to the rest of the class with reasoned explanations. The kits used in the lessons can be purchased from Anderson Scientific (sales@andersonscientific.co.uk). The solar cells were simply connected to a voltmeter. The wind and hydroelectric groups used the same basic equipment. This was made using a small water

  3. Health communication: lessons from research.

    Science.gov (United States)

    Shanmugam, A V

    1981-01-01

    In discussing the lessons learned from research in the area of health communication, focus is on basic strategic issues; the scope of health communications in terms of audience, information, education and motivation approaces and India's satellite Instructional Television Experiment (SITE). Health communication is the process by which a health idea is transferred from a source, such as a primary health center, to a receiver, community, with the intention of changing the community's behavior. This involves the formulation of specific strategies for the conduct of health and family welfare communication. In the processs of health communication, it has been a common practice in India as well as in other developing countries to depend upon a plethora of communication media. Yet, despite maximum utilization of the mass media and interpersonal channels of communication, questions remain about the efficacy of the system in bringing about change. Thus, the need to draw upon lessons from research becomes obvious. Communication effectiveness researches have concentrated on 3 basic strategic issues: the question of physical reception of messages by the audience; interpretation or understanding of messages on the part of the audience in accordance with the intention of the communicator; and effectiveness of communication on the cognitive, affective and behavioral dimensions of the audience. Innumberable researches in communication have provided several lessons which have expanded the scope of health communication. This expansion can be observed in terms of audiences reached, information disseminated, education undertaken, and motivation provided. Research has identified several distinct groups to whom specific health messages have to be addressed. These include government and political elites, health and family welfare program administrators, and the medical profession and clinical staff. Information on health needs to include both the concept of health and the pertinent ideas

  4. Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B.

    Science.gov (United States)

    Guo, Baojian; Hu, Shengquan; Zheng, Chengyou; Wang, Hongyu; Luo, Fangcheng; Li, Haitao; Cui, Wei; Yang, Xifei; Cui, Guozhen; Mak, Shinghung; Choi, Tony Chung-Lit; Ma, Edmond Dik-Lung; Wang, Yuqiang; Lee, Simon Ming Yuen; Zhang, Zaijun; Han, Yifan

    2017-11-01

    We have previously demonstrated the unexpected neuroprotection of the anti-cancer agent SU4312 in cellular models associated with Parkinson's disease (PD). However, the precise mechanisms underlying its neuroprotection are still unknown, and the effects of SU4312 on rodent models of PD have not been characterized. In the current study, we found that the protection of SU4312 against 1-methyl-4-phenylpyridinium ion (MPP + )-induced neurotoxicity in PC12 cells was achieved through the activation of transcription factor myocyte enhancer factor 2D (MEF2D), as evidenced by the fact that SU4312 stimulated myocyte enhancer factor 2 (MEF2) transcriptional activity and prevented the inhibition of MEF2D protein expression caused by MPP + , and that short hairpin RNA (ShRNA)-mediated knockdown of MEF2D significantly abolished the neuroprotection of SU4312. Additionally, Western blotting analysis revealed that SU4312 potentiated pro-survival PI3-K/Akt pathway to down-regulate MEF2D inhibitor glycogen synthase kinase-3beta (GSK3β). Furthermore, using the in vivo PD model of C57BL/6 mice insulted with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that intragastrical administration of SU4312 (0.2 and 1 mg/kg) greatly ameliorated Parkinsonian motor defects, and restored protein levels of MEF2D, phosphorylated-Ser473-Akt and phosphorylated-Ser9-GSK3β. Meanwhile, SU4312 effectively reversed the decrease in protein expression of tyrosine hydroxylase in substantia nigra pars compacta dopaminergic neurons, inhibited oxidative stress, maintained mitochondrial biogenesis and partially prevented the depletion of dopamine and its metabolites. Very encouragingly, SU4312 was able to selectively inhibit monoamine oxidase-B (MAO-B) activity both in vitro and in vivo, with an IC 50 value of 0.2 μM. These findings suggest that SU4312 provides therapeutic benefits in cellular and animal models of PD, possibly through multiple mechanisms including enhancement of MEF2D

  5. Lessons of the radiological accident in Goiania

    International Nuclear Information System (INIS)

    Alves, R.N.; Xavier, A.M.; Heilbron, P.F.L.

    1998-01-01

    On the basis of the lessons teamed from the radiological accident of Goiania, actions are described which a nuclear regulatory body should undertake while responding to an accident of this nature. (author)

  6. Why Gallipoli Matters: Interpreting Different Lessons

    National Research Council Canada - National Science Library

    Sullivan, John

    2003-01-01

    ...? Divergent views from the lessons of Gallipoli campaign are the result of three differing operational approaches to strategic considerations that Britain and the Unites States faced in the l92Os and l93Os...

  7. Energy deregulation: lessons from the American experience

    International Nuclear Information System (INIS)

    Chiam, L.

    1997-01-01

    This article presents a brief history of US energy regulation, considers some of the important issues arising from the US experience and finally, suggests some lessons which Australia might draw from the US deregulation of energy industries. 5 refs

  8. Planning geometry lessons with learning platforms

    DEFF Research Database (Denmark)

    Tamborg, Andreas Lindenskov

    mathematics teachers’ joint planning of a lesson in geometry with a learning platform called Meebook is analyzed using the instrumental approach. It is concluded that the interface in Meebook orients the teachers work toward what the students should do rather than what they should learn, although the latter......This paper investigates how mathematics teachers plan lessons with a recently implemented Danish learning platform designed to support teachers in planning lessons in line with a recent objective-oriented curriculum. Drawing on data from observations of and interviews with teachers, three...... is a key intention behind the implementation of the platform. It is also concluded that when the teachers succeed in using learning objectives actively in their planning, the objectives support the teachers in designing lessons that correspond with their intentions. The paper concludes with a discussion...

  9. Experimental Garden Plots for Botany Lessons

    Science.gov (United States)

    Gorodnicheva, V. V.; Vasil'eva, E. I.

    1976-01-01

    Discussion of the botany lessons used at two schools points out the need for fifth and sixth grade students to be taught the principles of plant life through observations made at an experimental garden plot at the school. (ND)

  10. Lessons from World War I

    Directory of Open Access Journals (Sweden)

    John Scales Avery

    2014-05-01

    Full Text Available The history of World War I is reviewed, starting with a discussion of the development of nationalist movements in Europe. It is pointed out that the global disaster started with a seemingly small operation by Austria, which escalated uncontrollably into an all-destroying conflagration. A striking feature of the war was that none of the people who started it had any idea of what it would be like. Technology had changed the character of war, but old patterns of thought remained in place. We also examine the roots of the war in industrial and colonial competition, and in an arms race. Finally, parallels with current events, and the important lessons for today’s world are discussed.

  11. WPPSS debacle: explanations and lessons

    International Nuclear Information System (INIS)

    Meyer, M.B.

    1984-01-01

    Principal explanations for the WPPSS events to date can be more or less satisfactorily derived. Five explanations appear to dominate: (1) the long and previously successful history of public power in the Pacific Northwest; (2) overoptimism by architect/engineers and consulting engineers about construction costs and construction durations; (3) laxness by bond counsel in scrutinizing and disclosing potential legal impediments to the various transactions involved; (4) WPPSS easy access to capital markets, combined with naivete in those markets; and (5) the inability of WPPSS to manage and oversee the construction process. This paper explains the specific reasons for, and the importance of, each of these five explanations for the WPPSS debacle. It then develops lessons and conclusions for the future which can be derived from this debacle. 12 references

  12. Lessons learned from external hazards

    Energy Technology Data Exchange (ETDEWEB)

    Peinador, Miguel; Zerger, Benoit [European Commisison Joint Research Centre, Petten (Netherlands). Inst. for Energy and Transport; Ramos, Manuel Martin [European Commission Joint Research Centre, Brussels (Belgium). Nuclear Safety and Security Coordination; Wattrelos, Didier [Institut de Radioprotection et de Surete Nucleaire (IRSN), Fontenay-aux-Roses (France); Maqua, Michael [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, Koeln (Germany)

    2014-01-15

    This paper presents a study performed by the European Clearinghouse of the Joint Research Centre on Operational Experience for nuclear power plants in cooperation with IRSN and GRS covering events reported by nuclear power plants in relation to external hazards. It summarizes the review of 235 event reports from 3 different databases. The events were grouped in 9 categories according to the nature of the external hazard involved, and the specific lessons learned and recommendations that can be derived from each of these categories are presented. Additional 'cross-cutting' recommendations covering several or all the external hazards considered are also discussed. These recommendations can be useful in preventing this type of events from happening again or in limiting their consequences. The study was launched in 2010 and therefore it does not cover the Fukushima event. This paper presents the main findings and recommendations raised by this study. (orig.)

  13. Lessons learned: wrong intraocular lens.

    Science.gov (United States)

    Schein, Oliver D; Banta, James T; Chen, Teresa C; Pritzker, Scott; Schachat, Andrew P

    2012-10-01

    To report cases involving the placement of the wrong intraocular lens (IOL) at the time of cataract surgery where human error occurred. Retrospective small case series, convenience sample. Seven surgical cases. Institutional review of errors committed and subsequent improvements to clinical protocols. Lessons learned and changes in procedures adapted. The pathways to a wrong IOL are many but largely reflect some combination of poor surgical team communication, transcription error, lack of preoperative clarity in surgical planning or failure to match the patient, and IOL calculation sheet with 2 unique identifiers. Safety in surgery involving IOLs is enhanced both by strict procedures, such as an IOL-specific "time-out," and the fostering of a surgical team culture in which all members are encouraged to voice questions and concerns. Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  14. Emergency preparedness lessons from Chernobyl

    International Nuclear Information System (INIS)

    Martin, J.B.

    1987-09-01

    Emergency preparedness at nuclear power plants in the US has been considerably enhanced since the Three Mile Island accident. The Chernobyl accident has provided valuable data that can be used to evaluate the merit of some of these enhancements and to determine the need for additional improvements. For example, the USSR intervention levels of 25 rem and 75 rem for evacuation are contrasted with US Environmental Protection Agency protective action guides. The manner in which 135,000 persons were evacuated from the 30-km zone around Chernobyl is constrasted with typical US evacuation plans. Meteorological conditions and particulate deposition patterns were studied to infer characteristics of the radioactive plume from Chernobyl. Typical plume monitoring techniques are examined in light of lessons learned by the Soviets about plume behavior. This review has indicated a need for additional improvements in utility and government emergency plans, procedures, equipment, and training. 12 refs., 1 fig., 2 tabs

  15. Chinese Lessons from Other Peoples’ Wars

    Science.gov (United States)

    2011-11-01

    as the lessons “not learned” or not adopted, the so-called “ dogs that do not bark.” While it may be difficult to parse real lessons learned from...under the barrel of the Type 95 5.8mm assault rifle. There is no muzzle brake or flash suppressor fitted and it is fed from a box magazine that

  16. With Interest It Comes To...Unconscionable Clauses in Sales Contracts. A Student's Lesson Plan [and] A Teacher's Lesson Plan [and] A Lawyer's Lesson Plan.

    Science.gov (United States)

    Howard, Estelle; And Others

    One of a series of secondary level teaching units presenting case studies with pro and con analysis of particular legal problems, the document presents a student's lesson plan, a teacher's lesson plan, and a lawyer's lesson plan on unconscionable clauses in sales contracts. The unit acquaints students with the operation of sales contracts and…

  17. [Remain true to our original aspiration for farewell to the God of Plague, compose the new chapter for the national schistosomiasis control programme scientifically-Commemoration of 60th anniversary of publishing Chairman Mao Zedong's two poems "Farewell to the God of Plague"].

    Science.gov (United States)

    Xiao-Nong, Zhou; Shi-Zhu, Li; Qing-Biao, Hong; Kun, Yang; Shan, Lü; Jing, Xu

    2018-02-26

    This paper reviews the huge promotion of Chairman Mao Zedong's two poems entitled "Farewell to the God of Plague" which were published 60 years ago, and the great achievements of the national schistosomiasis control programme in China. The publication of the two poems promotes the establishment of the mechanism for the national schistosomiasis control programme in China, and in addition, the schistosomiasis control spirit of the people from Yujiang County is still the source of power for the promotion of transferring the schistosomiasis control to elimination stage in China. Now, that we commemorate the 60th anniversary of publishing Chairman Mao Zedong's two poems entitled "Farewell to the God of Plague" means we remain the true to our original aspiration to serve the people forever, which is also to promote the progress of schistosomiasis elimination in China according to the law, the scientific principle, and local conditions, so as to contribute our efforts for realizing the healthy China's dream.

  18. Analysing the Integration of Engineering in Science Lessons with the Engineering-Infused Lesson Rubric

    Science.gov (United States)

    Peterman, Karen; Daugherty, Jenny L.; Custer, Rodney L.; Ross, Julia M.

    2017-01-01

    Science teachers are being called on to incorporate engineering practices into their classrooms. This study explores whether the Engineering-Infused Lesson Rubric, a new rubric designed to target best practices in engineering education, could be used to evaluate the extent to which engineering is infused into online science lessons. Eighty lessons…

  19. Beautiful Beads: A Lesson in Making Beads with Friendly Clay. AMACO[R] Lesson.

    Science.gov (United States)

    Gamble, Harriet; Gamble, David

    This lesson resource includes a brief summary of the history of bead making and historic fascination with beads as adornment. A focus on design elements, color theory, craftsmanship, and technical skill in bead making is encouraged. The plan includes lesson goals and objectives; background preparation; a glossary of terms; a list of supplies; and…

  20. A Lesson about the Circular Flow. Active Learning Lessons. Economics International.

    Science.gov (United States)

    Landfried, Janet

    This lesson plan was developed through "Economics International," an international program to help build economic education infrastructures in the emerging market economies. It provides a lesson description; appropriate grade level; economic concepts; content standards and benchmarks; related subjects; instructional objectives; time…

  1. Sequence analysis and transcript identification within 1.5 MB of DNA deleted together with the NDP and MAO genes in atypical Norrie disease patients presenting with a profound phenotype.

    Science.gov (United States)

    Suárez-Merino, B; Bye, J; McDowall, J; Ross, M; Craig, I W

    2001-06-01

    Mutations at the Norrie disease gene locus, NDP, manifest in a broad range of defects. These range from a relatively mild, late-onset, exudative vitreoretinopathy to congenital blindness and sensorineural deafness combined, in some cases, with mental retardation. In addition, extensive deletions involving the NDP locus, located at Xp11.3, the adjacent monoamine oxidadase genes MAOA and MAOB, and additional material, result in a more severe pattern of symptoms. The phenotypes include all or some of the following; mental retardation, involuntary movements, hypertensive crises and hypogonadism. We extended an existing YAC contig to embrace the boundaries of three of the largest deletions and converted this into four PAC contigs. Computer analysis and experimental data have resulted in the identification of several putative loci, including a phosphatase inhibitor 2-like gene (dJ154.1) and a 250-bp sequence which resembles a homeobox domain (dA113.3), 1.2 Mb and 400 kb respectively from the MAO/NDP cluster. The pattern of expression of dJ154.1 suggests that it may represent an important factor contributing to the complex phenotypes of these deletion patients. Hum Mutat 17:523, 2001. Copyright 2001 Wiley-Liss, Inc.

  2. Ab initio study of the structure and stability of carbonates, silicates, nitrates, phosphates, borates and aluminates L2AO3 and MAO3 (L=Li, Na; M=Be, Mg; A=C, Si, N+, P+, B-, Al-)

    International Nuclear Information System (INIS)

    Charkin, D.O.; Makku, M.L.; Charkin, O.P

    1998-01-01

    Nonempiric calculations of potential energy surfaces of molecules and ions of lithium and sodium oxosalts of the L 2 AO 3 type and beryllium and magnesium salts of the MAO 3 type with 24 valent electrons (L=Li, Na; M=Be, Mg; A=C, Si, N + , P + , B - , Al - ) are accomplished within the frames of the MP2/6-31G * +ZPE(HF/6-31G * ) and MP4SDTQ/6-31+G * //MP2/6-31G * +ZPE(MP2/6-31G * )approximations. Equilibriumgeometrical parameters and relative energy of isomers and energy of their decomposition, IR-frequencies and intensities of normal oscillations are determined; trends in their change in various series of molecules and ions are analyzed. Deformation and polarization of the AO 3 trigonal oxoanions under the effect of alkali and alkaline-earth cations, ortho-meta-isomerism in negative ions of the MBO 3 - borates and MACO 3 - aluminates, as well as effect of electron correlation on calculation results are determined. The results are compared with the data of previous calculations of isoelectron lithium and sodium salts LAO 3

  3. Analysing the integration of engineering in science lessons with the Engineering-Infused Lesson Rubric

    Science.gov (United States)

    Peterman, Karen; Daugherty, Jenny L.; Custer, Rodney L.; Ross, Julia M.

    2017-09-01

    Science teachers are being called on to incorporate engineering practices into their classrooms. This study explores whether the Engineering-Infused Lesson Rubric, a new rubric designed to target best practices in engineering education, could be used to evaluate the extent to which engineering is infused into online science lessons. Eighty lessons were selected at random from three online repositories, and coded with the rubric. Overall results documented the strengths of existing lessons, as well as many components that teachers might strengthen. In addition, a subset of characteristics was found to distinguish lessons with the highest level of engineering infusion. Findings are discussed in relation to the potential of the rubric to help teachers use research evidence-informed practice generally, and in relation to the new content demands of the U.S. Next Generation Science Standards, in particular.

  4. Feedback of safety - related operational experience: Lessons learned

    Energy Technology Data Exchange (ETDEWEB)

    Elias, D [Commonwealth Edison Co. (United States)

    1997-09-01

    The presentation considers the following aspects of feedback of safety-related operational experience: lessons learned program, objectives, personnel characteristics; three types of documents for transmitting lessons learned issues.

  5. Mini-Lessons on Language (The Round Table).

    Science.gov (United States)

    English Journal, 1993

    1993-01-01

    Describes several successful lessons that provide students with new awareness of the English language. Includes lessons focusing on language change, onomatopoeia, slang, word origin, dialect, and language functions. (MM)

  6. Lessons from Early Medicaid Expansions Under Health Reform..

    Data.gov (United States)

    U.S. Department of Health & Human Services — Lessons from Early Medicaid Expansions Under Health Reform, Interviews with Medicaid Officials In a new study entitled Lessons from Early Medicaid Expansions Under...

  7. Feedback of safety - related operational experience: Lessons learned

    International Nuclear Information System (INIS)

    Elias, D.

    1997-01-01

    The presentation considers the following aspects of feedback of safety-related operational experience: lessons learned program, objectives, personnel characteristics; three types of documents for transmitting lessons learned issues

  8. N Reactor Lessons Learned workshop

    International Nuclear Information System (INIS)

    Heaberlin, S.W.

    1993-07-01

    This report describes a workshop designed to introduce participants to a process, or model, for adapting LWR Safety Standards and Analysis Methods for use on rector designs significantly different than LWR. The focus of the workshop is on the ''Lessons Learned'' from the multi-year experience in the operation of N Reactor and the efforts to adapt the safety standards developed for commercial light water reactors to a graphite moderated, water cooled, channel type reactor. It must be recognized that the objective of the workshop is to introduce the participants to the operation of a non-LWR in a LWR regulatory world. The total scope of this topic would take weeks to provide a through overview. The objective of this workshop is to provide an introduction and hopefully establish a means to develop a longer term dialogue for technical exchange. This report provides outline of the workshop, a proposed schedule of the workshop, and a description of the tasks will be required to achieve successful completion of the project

  9. Achievements and Lessons from Tevatron

    International Nuclear Information System (INIS)

    Shiltsev, V.

    2011-01-01

    For almost a quarter of a century, the Tevatron proton-antiproton collider was the centerpiece of the world's high energy physics program - beginning operation in December of 1985 until it was overtaken by LHC in 2011. The aim of the this unique scientific instrument was to explore the elementary particle physics reactions with center of mass collision energies of up to 1.96 TeV. The initial design luminosity of the Tevatron was 10 30 cm -2 s -1 , however as a result of two decades of upgrades, the accelerator has been able to deliver 430 times higher luminosities to each of two high luminosity experiments, CDF and D0. Tevatron will be shut off September 30, 2011. The collider was arguably one of the most complex research instruments ever to reach the operation stage and is widely recognized for many technological breakthroughs and numerous physics discoveries. Below we briefly present the history of the Tevatron, major advances in accelerator physics, and technology implemented during the long quest for better and better performance. We also discuss some lessons learned from our experience.

  10. FRMAC-93 lessons learned report

    International Nuclear Information System (INIS)

    Kerns, K.C.

    1994-03-01

    FRMAC-93 simulated a radiological accident at the Fort Calhoun nuclear power plant, 25 miles north of Omaha, Nebraska. The exercise involved the state Iowa and Nebraska, NRC as the lead Federal agency, FRMAC (Federal Radiological Monitoring and Assessment Center), and several federal agencies with statutory emergency responsibility. FRMAC-93 was a major 2-day field exercise designed to determine the effectiveness, coordination, and operations of a DOE-managed FRMAC. Other objectives were to ensure that appropriate priorities were established and assistance was provided to the states and the lead Federal agency by FRMAC. Day 1 involved the Fort Calhoun evaluated plume phase exercise. On Day 2, the flow of data, which was slow initially, improved so that confidence of states and other federal responders in FRMAC support capabilities was high. The impact and lessons learned from FRMAC-93 provided the necessary impetus to make organizational and operational changes to the FRMAC program, which were put into effect in the DOE exercise FREMONT at Hanford 3 months later

  11. Science and Sandy: Lessons Learned

    Science.gov (United States)

    Werner, K.

    2013-12-01

    Following Hurricane Sandy's impact on the mid-Atlantic region, President Obama established a Task Force to '...ensure that the Federal Government continues to provide appropriate resources to support affected State, local, and tribal communities to improve the region's resilience, health, and prosperity by building for the future.' The author was detailed from NOAA to the Task Force between January and June 2013. As the Task Force and others began to take stock of the region's needs and develop plans to address them, many diverse approaches emerged from different areas of expertise including: infrastructure, management and construction, housing, public health, and others. Decision making in this environment was complex with many interests and variables to consider and balance. Although often relevant, science and technical expertise was not always at the forefront of this process. This talk describes the author's experience with the Sandy Task Force focusing on organizing scientific expertise to support the work of the Task Force. This includes a description of federal activity supporting Sandy recovery efforts, the role of the Task Force, and lessons learned from developing a science support function within the Task Force.

  12. Knowledge and Cognitive Process Dimensions of Technology Teachers' Lesson Objectives

    Science.gov (United States)

    Mathumbu, David; Rauscher, Willem; Braun, Max

    2014-01-01

    A clearly stated lesson objective is considered an essential component of a well-planned lesson. Many teachers of Technology, a relatively new subject in South African schools, teach Technology with rather limited training both in content and methodological approaches. This study sought to investigate and classify lesson objectives framed or…

  13. The physical education lesson in Turkish primary schools: Affective ...

    African Journals Online (AJOL)

    In the study students' affective entry characteristics related to Physical Education lessons were examined based on three dimensions: interest towards the lesson, level of motivation in the lesson and educational gains. The study further aimed to investigate how these three dimensions were affected by the gender factor.

  14. Craft Lessons: Teaching Writing K-8. Second Edition

    Science.gov (United States)

    Fletcher, Ralph; Portalupi, JoAnn

    2007-01-01

    Since its publication in 1998 Craft Lessons has become a mainstay of writing teachers, both new and experienced. Practical lessons--each printed on one page--and the instructional language geared to three grade-level groupings: K-2, 3-4, and 5-8 are contained in this book. In the decade since Craft Lessons' publication the world has changed in…

  15. Plant Identification Characteristics for Deciduous Trees & Shrubs. Lesson Plans.

    Science.gov (United States)

    Burkholder, Kathy

    This manual contains a group of lesson plans designed for use with a slide series (not included here). Its purpose is to introduce students to the basic concepts and terminology used in the identification of deciduous trees and shrubs. The manual is composed of 12 lesson plans. The first lesson is an introduction to plant identification. The…

  16. Inductive & Deductive Science Thinking: A Model for Lesson Development

    Science.gov (United States)

    Bilica, Kim; Flores, Margaret

    2009-01-01

    Middle school students make great learning gains when they participate in lessons that invite them to practice their developing scientific reasoning skills; however, designing developmentally appropriate, clear, and structured lessons about scientific thinking and reasoning can be difficult. This challenge can be met through lessons that teach…

  17. A Qualitative Study on Primary School Mathematics Lesson Evaluation

    Science.gov (United States)

    Zhao, Dongchen; Ma, Yunpeng

    2009-01-01

    Through the qualitative interviews of five implementers of primary school mathematics curriculum, this study addresses the ways in which mathematics lessons are evaluated. Results show that each evaluator recognizes different aspects of a "good lesson," however, among all criteria, the design of the lesson plan, realization of the lesson…

  18. ELPSA AS A LESSON DESIGN FRAMEWORK

    Directory of Open Access Journals (Sweden)

    Tom Lowrie

    2015-07-01

    Full Text Available This paper offers a framework for mathematics lesson design that is consistent with the way we learn about, and discover, most things in life. In addition, the framework provides a structure for identifying how mathematical concepts and understanding are acquired and developed. This framework is called ELPSA and represents five learning components, namely: Experience, Language, Pictorial, Symbolic and Applications. This framework has been used in developing lessons and teacher professional programs in Indonesia since 2012 in cooperation with the World Bank. This paper describes the theory that underlines the framework in general and in relation to each inter-connected component. Two explicit learning sequences for classroom practice are described, associated with Pythagoras theorem and probability. This paper then concludes with recommendations for using ELPSA in various institutional contexts.Keywords: ELPSA, lesson design framework, Pythagoras theorem, probability DOI: dx.doi.org/10.22342/jme.62.77

  19. Applying Lessons from SN Studies to GRBs

    International Nuclear Information System (INIS)

    Fryer, Chris L.

    2009-01-01

    Supernovae and Gamma-Ray bursts display many similarities, both in their observational qualities and in the engines behind these powerful explosions. Although not identical, there is a strong synergy in the study of these two objects. There is much the gamma-ray burst field can learn from the lessons of the more-developed supernova field, but the supernova field can also learn from new techniques developed for gamma-ray burst studies. Here I review some of the 'lessons learned' from these fields to help foster this synergy.

  20. Lessons learned from early criticality accidents

    International Nuclear Information System (INIS)

    Malenfant, R.E.

    1996-01-01

    Four accidents involving the approach to criticality occurred during the period July, 1945, through May, 1996. These have been described in the format of the OPERATING EXPERIENCE WEEKLY SUMMARY which is distributed by the Office of Nuclear and Facility Safety. Although the lessons learned have been incorporated in standards, codes, and formal procedures during the last fifty years, this is their first presentation in this format. It is particularly appropriate that they be presented in the forum of the Nuclear Criticality Technology Safety Project Workshop closest to the fiftieth anniversary of the last of the four accidents, and that which was most instrumental in demonstrating the need to incorporate lessons learned

  1. Lessons Learned In Developing The VACIS Products

    International Nuclear Information System (INIS)

    Orphan, Victor J.

    2011-01-01

    SAIC's development of VACIS provides useful 'lessons learned' in bridging the gap from an idea to a security or contraband detection product. From a gamma densitometer idea for solving a specific Customs Service (CS) requirement (detection of drugs in near-empty tanker trucks) in mid-1990's, SAIC developed a broad line of vehicle and cargo inspections systems (over 500 systems deployed to date) based on a gamma-ray radiographic imaging technique. This paper analyzes the reasons for the successful development of VACIS and attempts to identify ''lessons learned'' useful for future security and contraband detection product developments.

  2. Biotech Business Lessons for Defense Acquisition

    Science.gov (United States)

    2016-01-01

    repudiates what func- tional personnel hold dear—that their hurdles are vital to some moral or ethical responsibility to protect or safeguard...94 Strategic Studies Quarterly ♦ Summer 2016 Biotech Business Lessons for Defense Acquisition Col David L. Peeler Jr., USAF Abstract The desire to...examples and lessons from private business sectors would serve DOD interests well. ✵ ✵ ✵ ✵ ✵ Acquisition reform! No other two words so stress or trouble

  3. Lessons Learned from ISS Cooperation

    Science.gov (United States)

    Jolly, C.

    2002-01-01

    Forty years of human spaceflight activities are now culminating in the International Space Station program (ISS). The ISS involves fifteen nations, working together to create a permanently occupied orbital facility that will support scientific and potentially, commercial endeavours. The assembly of the ISS is scheduled to be completed later in this decade, after which it will be operated for at least ten years. At the strategic level, such a complex international project is highly dependent on the fifteen Partners' respective internal politics and foreign policies. On the operational level, Partners still have certain difficulties in issuing and agreeing to common technical procedures. As with almost all aspects of International Space Station cooperation, the Partners are going through a constant learning process, where they have to deal with complex political, legal and operational differences. Intergovernmental Agreement and the Memoranda of Understanding, the instruments forming the legal backbone of the International Space Station cooperation, are still lacking a fair number of arrangements that need to be created for completing and operating the Station. The whole endeavour is also a constant learning process at the operational level, as astronauts, cosmonauts, engineers and technicians on the ground with different cultural and educational backgrounds, learn to work together. One recent Space Shuttle mission to the Station showed the importance of standardising even trivial system components such as packaging labels, as it took the astronauts half a day more than planned to correctly unpack the equipment. This paper will provide a synthesis of some of the main lessons learned during the first few years of International Space Station's lifetime. Important political, legal and operational issues will be addressed and combined. This analysis will provide some guidelines and recommendations for future international space projects, such as an international human

  4. Lessons from Fukushima - February 2012

    International Nuclear Information System (INIS)

    Morris-Suzuki, Tessa; Boilley, David; McNeill, David; Gundersen, Arnie; Beranek, Jan; Blomme, Brian; Hanaoka, Wakao; Schulz, Nina; Stensil, Shawn-Patrick; Teule, Rianne; Tumer, Aslihan; McCann, Christine; Otani, Nanako; Hirsch, Helmut

    2012-01-01

    It has been almost 12 months since the Fukushima nuclear disaster began. Although the Great East Japan earthquake and the following tsunami triggered it, the key causes of the nuclear accident lie in the institutional failures of political influence and industry-led regulation. It was a failure of human institutions to acknowledge real reactor risks, a failure to establish and enforce appropriate nuclear safety standards and a failure to ultimately protect the public and the environment. This report, commissioned by Greenpeace International, addresses what lessons can be taken away from this catastrophe. The one-year memorial of the Fukushima accident offers a unique opportunity to ask ourselves what the tragedy - which is far from being over for hundreds of thousands of Japanese people - has taught us. And it also raises the question, are we prepared to learn? There are broader issues and essential questions that still deserve our attention: - How it is possible that - despite all assurances - a major nuclear accident on the scale of the Chernobyl disaster of 1986 happened again, in one of the world's most industrially advanced countries? - Why did emergency and evacuation plans not work to protect people from excessive exposure to the radioactive fallout and resulting contamination? Why is the government still failing to better protect its citizens from radiation one year later? - Why are the over 100,000 people who suffer the most from the impacts of the nuclear accident still not receiving adequate financial and social support to help them rebuild their homes, lives and communities? These are the fundamental questions that we need to ask to be able to learn from the Fukushima nuclear disaster. This report looks into them and draws some important conclusions: 1. The Fukushima nuclear accident marks the end of the 'nuclear safety' paradigm. 2. The Fukushima nuclear accident exposes the deep and systemic failure of the very institutions that are supposed to

  5. The Role of a Commander in Military Lessons Learned Systems

    Directory of Open Access Journals (Sweden)

    Zenon Waliński

    2015-06-01

    Full Text Available The aim of the paper is to investigate the role of a commander in military Lessons Learned systems. In order to achieve the aim, the paper presents (1 the architecture of the Lessons Learned capabilities in the U.S. Army, NATO and the Polish Armed Forces, (2 the commander’s role in the Lessons Learned process (3 the commander’s role in fostering Lessons Learned organisation culture. The paper is based on multiple case study analysis including Lessons Learned systems in NATO, the U.S. Army and the Polish Armed Forces.

  6. Sample Lesson Plans. Management for Effective Teaching.

    Science.gov (United States)

    Fairfax County Public Schools, VA. Dept. of Instructional Services.

    This guide is part of the Management for Effective Teaching (MET) support kit, a pilot project developed by the Fairfax County (Virginia) Public Schools to assist elementary school teachers in planning, managaing, and implementing the county's curriculum, Program of Studies (POS). In this guide, a sample lesson plan of a teaching-learning activity…

  7. Promoting Systems Thinking through Biology Lessons

    Science.gov (United States)

    Riess, Werner; Mischo, Christoph

    2010-01-01

    This study's goal was to analyze various teaching approaches within the context of natural science lessons, especially in biology. The main focus of the paper lies on the effectiveness of different teaching methods in promoting systems thinking in the field of Education for Sustainable Development. The following methods were incorporated into the…

  8. Teaching about Terrorism: Lessons Learned at SWOTT

    Science.gov (United States)

    Miller, Gregory D.

    2009-01-01

    This article discusses some of the challenges and lessons for teaching undergraduate-level courses related to terrorism. The author outlines some of the primary issues that instructors can expect to face, and provides strategies for dealing with several of these challenges. The goal is to relay useful information to those teaching, or planning to…

  9. Jackie Steals Home. Learning Page Lesson Plan.

    Science.gov (United States)

    Pulda, Arnold

    In this lesson, students draw on their previous studies of American history and culture as they analyze primary sources from "Jackie Robinson and Other Baseball Highlights, 1860s-1960s" in the American Memory collection. A close reading of two documents relating to Jackie Robinson's breaking of the racial barrier in professional baseball…

  10. Arts Impact: Lessons from ArtsBridge

    Science.gov (United States)

    Shimshon-Santo, Amy R.

    2010-01-01

    Arts Impact summarizes lessons learned at the ArtsBridge Program. It is informed by in-depth participant observation, logic modeling, and quantitative evaluation of program impact on K-12 students in inner city schools and arts students at the University of California Los Angeles over a two year period. The case study frames its analysis through a…

  11. Lessons in Spiritual Leadership from Kenyan Women

    Science.gov (United States)

    Ngunjiri, Faith Wambura

    2010-01-01

    Purpose: The purpose of this paper is to explicate spiritual leadership lessons of beneficence, courage, hope and ubuntu/humanness that are derived from the experiences of women leaders in Kenya. The paper seeks to connect African data with existing literature on spiritual leadership, to demonstrate where African spiritual leadership is similar…

  12. What Teachers Understand of Model Lessons

    Science.gov (United States)

    Courtney, Scott A.

    2017-01-01

    Over the past two decades, researchers in mathematics teacher education have identified characteristics of high quality professional development (PD). This report describes an investigation of a common approach to PD with secondary mathematics teachers, providing teachers with opportunities to experience reform-oriented model lessons as students…

  13. Most Effective Practices in Lesson Planning

    Science.gov (United States)

    Womack, Sid T.; Pepper, Stephanie; Hanna, Shellie L.; Bell, Columbus David

    2015-01-01

    In a previous study with 130 undergraduate teacher candidates from all licensure levels, data on candidate effectiveness were examined using factor analysis. Four factors were found in effective teaching, those being lesson planning, teacher and student reflection, safe school environment, and teacher professionalism. The present study followed…

  14. Lessons learned on digital systems safety

    International Nuclear Information System (INIS)

    Sivertsen, Terje

    2005-06-01

    A decade ago, in 1994, lessons learned from Halden research activities on digital systems safety were summarized in the reports HWR-374 and HWR-375, under the title 'A Lessons Learned Report on Software Dependability'. The reports reviewed all activities made at the Halden Project in this field since 1977. As such, the reports provide a wealth of information on Halden research. At the same time, the lessons learned from the different activities are made more accessible to the reader by being summarized in terms of results, conclusions and recommendations. The present report provides a new lessons learned report, covering the Halden Project research activities in this area from 1994 to medio 2005. As before, the emphasis is on the results, conclusions and recommendations made from these activities, in particular how they can be utilized by different types of organisations, such as licensing authorities, safety assessors, power companies, and software developers. The contents of the report have been edited on the basis of input from a large number of Halden work reports, involving many different authors. Brief summaries of these reports are included in the last part of the report. (Author)

  15. Oil prices: demand and supply. Lesson plan

    OpenAIRE

    anonymous

    2005-01-01

    Upon completion of this lesson, students will be able to list the determinants of demand and supply, recognize which factors will cause demand curves or supply curves to shift, determine equilibrium using a demand/supply graph, and show the effects on price and quantity when equilibrium changes.

  16. Lessons from the Electricity Auctions in Brazil

    International Nuclear Information System (INIS)

    Dutra, Joisa; Menezes, Flavio

    2005-01-01

    The first lesson to emerge from the recent auctions falls within a category that might be described as 'higher costs of reforms in developing economies.' These range from bidders' fears of future government-imposed price caps to technical issues, such as the potential loss of efficiency resulting from bidders' lack of knowledge about ceiling prices, reference supply, and the demand reduction mechanism

  17. A Lesson in Classroom Size Reduction.

    Science.gov (United States)

    Hymon, Steve

    1997-01-01

    The goal of California's classroom size reduction (CSR) program is to have 20 or fewer students in kindergarten through grade 3 classrooms. Districts receive $650 for each student in a reduced classroom. Describes how districts implemented the plan and offers five lessons from struggles and successes with CSR. A table displays average elementary…

  18. Two Approaches to Distance Education: Lessons Learned.

    Science.gov (United States)

    Sedlak, Robert A.; Cartwright, G. Phillip

    1997-01-01

    Outlines lessons learned by the University of Wisconsin-Stout in implementing two distance education programs, a technology program using interactive television and a hospitality program using Lotus Notes to deliver courses. Topics discussed include program concept vs. technology as stimulus for innovation, program planning/administration,…

  19. Lessons Learned from the Private Sector

    Energy Technology Data Exchange (ETDEWEB)

    Robichaud, Robert J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-07

    This session is focused on lessons learned from private sector energy projects that could be applied to the federal sector. This presentation tees up the subsequent presentations by outlining the differences between private and federal sectors in objectives, metrics for determining success, funding resources/mechanisms, payback and ROI evaluation, risk tolerance/aversion, new technology adoption perspectives, and contracting mechanisms.

  20. Lessons Learned from a Consultation Process Overseas

    Science.gov (United States)

    Merino-Soto, César

    2014-01-01

    In this commentary I discuss three international school consultation experiences, highlighting aspects that serve as lessons for professional development and the implementation of effective and helpful strategies that meet the needs of children and youth in school systems. Relationships developed and maintained between the consulting teams and the…

  1. Commissioning MMS: Challenges and Lessons Learned

    Science.gov (United States)

    Wood, Paul; Gramling, Cheryl; Reiter, Jennifer; Smith, Patrick; Stone, John

    2016-01-01

    This paper discusses commissioning of NASA's Magnetospheric MultiScale (MMS) Mission. The mission includes four identical spacecraft with a large, complex set of instrumentation. The planning for and execution of commissioning for this mission is described. The paper concludes by discussing lessons learned.

  2. Regionalization: A Story Map Lesson on Regions

    Science.gov (United States)

    Edmondson, Deborah

    2018-01-01

    This lesson introduces the concept of regionalization and types of regions. After a brief introductory activity, students explore a story map to learn the material. The teacher can project the story map on a screen for all students to follow or students may work individually on computers. Working individually will allow students to set their own…

  3. Finnish Students’ Engagement in Science Lessons

    Directory of Open Access Journals (Sweden)

    Janna Linnansaari

    2015-05-01

    Full Text Available The decreasing number of students who are engaged in science learning has been recognised as a problem. The pre-conditions of engagement and actual engagement were examined using a novel research method to obtain detailed information on Finnish students’ engagement in different situations and to gain a better understanding of this phenomenon. The study’s participants consisted of 68 students (31 girls, 37 boys from 9th grade and 67 students (46 girls, 21 boys from 1st grade in upper secondary school. The research aimed to answer the following question: How does Finnish students’ engagement occur in exact and life science lessons? Participants received smartphones equipped with a smartphone application that included an experience sampling method questionnaire. The smartphones were programmed to emit a signal during every science lesson and otherwise randomly during the day (from 8 am to 8 pm. The results reveal that situation and grade had significant effects on students’ pre-conditions of engagement and actual engagement. Our results also show that girls had the highest interest in life science lessons and boys in exact science lessons.

  4. [Heritage Education Lesson Plans and Slide Presentations].

    Science.gov (United States)

    Van Buren, Maurie

    Field tested in 27 schools and in grades four through twelve, this teaching unit stresses heritage education through the study of southern U.S. architectural styles for homes from the pioneer log structures to the 1950s ranch home. Each of the four lessons in this unit focuses around a slide presentation of 20 slides designed to fit into one…

  5. Winter Secrets: An Instant Lesson Plan.

    Science.gov (United States)

    Collyer, Cam

    1997-01-01

    Outdoor lesson plan aims to stimulate student interest in animals' adaptations to winter and the various signs and clues to animal behavior. Includes questions for class discussion, tips for guiding the hike, and instructions for two games that illustrate the predator-prey relationship. Notes curriculum connections to the East York (Ontario) Board…

  6. Library 101: Why, How, and Lessons Learned

    Science.gov (United States)

    Porter, Michael; King, David Lee

    2010-01-01

    This article describes how and why the Library 101 Project was created and the lessons that the developers learned out of this project. The Library 101 is a project that challenges librarians to revise the paradigm of "basic" library services in order to remain relevant in this technology-driven world. It was developed by Michael Porter,…

  7. Listening Skills. Instructor/Lesson Guide.

    Science.gov (United States)

    Decker, Carol; And Others

    This instructor/lesson guide provides instructional materials for a 4-hour course in listening skills in the workplace. Stated objectives are to help students to become more effective listeners, to assist students in obtaining an understanding of how effective they are as listeners, and to assist students in identifying bad listening habits. Two…

  8. Parental Involvement in Children's Independent Music Lessons

    Science.gov (United States)

    Upitis, Rena; Abrami, Philip C.; Brook, Julia; King, Matthew

    2017-01-01

    The purpose of the study was to examine types of parental involvement associated with independent music lessons. A self-report survey was designed to explore parent characteristics, parental goals, students' musical progress, the teacher-student relationship, the practice environment, and parent behaviours during practice sessions. The extent to…

  9. Improving IT Project Portfolio Management: Lessons Learned

    DEFF Research Database (Denmark)

    Pedersen, Keld

    2013-01-01

    The IT PPM improvement process is not well understood, and our knowledge about what makes IT PPM improvement succeed or fail is not well developed. This article presents lessons learned from organizations trying to improve their IT PPM practice. Based on this research IT PPM practitioners are adv...

  10. Twain's "Hannibal." Learning Page Lesson Plan.

    Science.gov (United States)

    Wood, Jan; Thiese, Norma

    Writers are influenced by their environment including family, community, lifestyle, or location. One such writer was Mark Twain. With this lesson plan the learner will become familiar with and analyze life around Mark Twain's hometown, Hannibal, Missouri, during the latter half of the 19th century by using various online and print resources to…

  11. The Activity Structure of Lesson Segments.

    Science.gov (United States)

    Burns, Robert B.; Anderson, Lorin W.

    1987-01-01

    Approaches classroom instruction and teacher effectiveness by conceptualizing the physical milieu shaping teacher-student interactions. Lessons are viewed as a series of segments with three components (purpose, activity format, and assignment) that help characterize the instructional environment. Scripts are suggested to help regulate activity…

  12. Lessons in Outbreak a Consumer perspective

    NARCIS (Netherlands)

    Fischer, A.R.H.

    2008-01-01

    Lessons in Outbreak a Consumer perspective. Arnout Fischer Consumer risk perceptions is not necessarily the same as an economic weighing of risks and benefits. Consumers tend to be risk averse, tend to estimate catastrophic, unnatural or involuntary risks as larger, while personal lifestyle risks

  13. Lessons learned from existing biomass power plants

    Energy Technology Data Exchange (ETDEWEB)

    Wiltsee, G.

    2000-02-24

    This report includes summary information on 20 biomass power plants, which represent some of the leaders in the industry. In each category an effort is made to identify plants that illustrate particular points. The project experiences described capture some important lessons learned that lead in the direction of an improved biomass power industry.

  14. Rural Entrepreneurship in Nigeria: Lessons From Scientific ...

    African Journals Online (AJOL)

    This article focussed on the lessons that can be garnered from the tenets of Scientific Management. We undertook an X-ray of the tenets of Scientific Management and how these tenets can be adopted to ensure the success of emerging entrepreneurs in the rural areas. Many rural entrepreneurs fail within a short period of ...

  15. Lessons learned from failure analysis

    International Nuclear Information System (INIS)

    Le May, I.

    2006-01-01

    Failure analysis can be a very useful tool to designers and operators of plant and equipment. It is not simply something that is done for lawyers and insurance companies, but is a tool from which lessons can be learned and by means of which the 'breed' can be improved. In this presentation, several failure investigations that have contributed to understanding will be presented. Specifically, the following cases will be discussed: 1) A fire at a refinery that occurred in a desulphurization unit. 2) The failure of a pipeline before it was even put into operation. 3) Failures in locomotive axles that took place during winter operation. The refinery fire was initially blamed on defective Type 321 seamless stainless steel tubing, but there were conflicting views between 'experts' involved as to the mechanism of failure and the writer was called upon to make an in-depth study. This showed that there were a variety of failure mechanism involved, including high temperature fracture, environmentally-induced cracking and possible manufacturing defects. The unraveling of the failure sequence is described and illustrated. The failure of an oil transmission was discovered when the line was pressure tested some months after it had been installed and before it was put into service. Repairs were made and failure occurred in another place upon the next pressure test being conducted. After several more repairs had been made the line was abandoned and a lawsuit was commenced on the basis that the steel was defective. An investigation disclosed that the material was sensitive to embrittlement and the causes of this were determined. As a result, changes were made in the microstructural control of the product to avoid similar problems in future. A series of axle failures occurred in diesel electric locomotives during winter. An investigation was made to determine the nature of the failures which were not by classical fatigue, nor did they correspond to published illustrations of Cu

  16. Lessons learned in CMAM implementation

    International Nuclear Information System (INIS)

    Dent, Nicky; Brown, Rebecca

    2014-01-01

    -going. Despite the need to adapt protocols and approaches to each specific context, there is a need for a common research agenda and sharing of what works and does not. Concerted efforts have been made to improve information-sharing and to draw on lessons learned to advance technical and organisational challenges. However many health workers have limited access to quality information due to barriers such as internet access and language. For example, one recent initiative identified less than 10% of resources are available in French, despite high caseloads of acute malnutrition in francophone West Africa. Key actions to address challenges in information-sharing include: -Improve availability of and access to translated information -Increase use of social media, e-learning and audio-visual materials for extended reach and use of information -Stimulate interactive dialogue and sharing between practitioners for improved problem solving and learning -Strengthen the collaboration between complementary initiatives. In one decade significant advances in the adaptation and implementation of community-based management of acute malnutrition approach have been made in various contexts, but challenges to quality service delivery, scale-up and sustainability remain. It is time to draw on what we know to support scale-up and have equitable access to treatment to the millions of children who still remain outside of existing services. (author)

  17. 2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.

    Science.gov (United States)

    Prado-Prado, Francisco; García-Mera, Xerardo; Escobar, Manuel; Sobarzo-Sánchez, Eduardo; Yañez, Matilde; Riera-Fernandez, Pablo; González-Díaz, Humberto

    2011-12-01

    large DPIs databases in order to discover both new drugs and/or targets. Finally, we illustrated in one theoretic-experimental study the practical use of 2D MI-DRAGON. We reported the prediction, synthesis, and pharmacological assay of 10 different oxoisoaporphines with MAO-A inhibitory activity. The more active compound OXO5 presented IC(50) = 0.00083 μM, notably better than the control drug Clorgyline. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  18. English language-in-education: A lesson planning model for subject ...

    African Journals Online (AJOL)

    English language-in-education: A lesson planning model for subject teachers. ... lack of critical academic language skills in English as the Language of Learning and ... process of lesson design and the 'forward' process of lesson presentation.

  19. Sharing Lessons Learned Between Industries in EU

    International Nuclear Information System (INIS)

    Muehleisen, A.; Strucic, M.

    2012-01-01

    Recent events in nuclear industry remind us on importance of continuous sharing of the knowledge and experience gained through evaluations of incidents and accidents. We frequently use experience from our daily life activities to improve our performance and avoid some mistakes or unwanted events. In the similar way we can use other industries experience. These experiences can be applied to improve nuclear safety. For example, Safety Culture, which has a great influence on the level of nuclear power plants safety, is similarly presented in other industries. Mechanisms which led to accidents from weak safety culture in one branch of other industry could be comparable to those in nuclear industry. Some other industries have many more cumulative years of experience than nuclear industry. Aviation and Oil industries are typical representatives. Part of their experience can be used in nuclear industry too. Number of reports from nuclear power plants showed us that not only specific equipment related causes lay behind accidents; there are also other causes and contributors which are more common for all industries. Hence lessons learned in other industry should be assessed and used in nuclear industry too. In the European Union, a regional initiative has been set up in 2008 in support of EU Member State nuclear safety authorities, but also EU technical support organizations, international organizations and the broader nuclear community, to enhance nuclear safety through improvement of the use of lessons learned from operational experience of nuclear power plants (NPPs). The initiative, called ''the EU Clearinghouse on Operational Experience Feedback for NPP'', is organized as a network operated by a centralized office located at the Joint Research Centre of the European Commission. The reduction of occurrence and significance of events in NPPs and their safe operation is its ultimate goal. Among others EU Clearinghouse provides services such as technical and scientific

  20. Lessons learned in terms of crisis management

    International Nuclear Information System (INIS)

    2006-01-01

    This document outlines that nobody was prepared to the crisis which occurred after the Chernobyl accident, whether in Russia, Europe or France. In order to illustrate the fact that crisis management has been different from one country to another, the report describes how the crisis has been managed in Norway (which has been quickly reached by fallouts and with a rather high level) and in Switzerland. It comments radioactivity measurements performed in France during spring 1986 by the SCPRI, the CEA and the ISPN. It discusses the lessons drawn in France in terms of emergency situation management regarding the protection of the population, crisis management, and the French post-accidental doctrine. It comments the lessons drawn in eastern European countries, with the cooperative implication of the IRSN. International projects are evoked: the Chernobyl Centre, the French-German Initiative, the European projects (EURANOS, NERIS, FARMING, STRATEGY, MOSES and SAMEN)

  1. ELPSA as A Lesson Design Framework

    Directory of Open Access Journals (Sweden)

    Tom Lowrie

    2015-07-01

    Full Text Available This paper offers a framework for mathematics lesson design that is consistent with the way we learn about, and discover, most things in life. In addition, the framework provides a structure for identifying how mathematical concepts and understanding are acquired and developed. This framework is called ELPSA and represents five learning components, namely: Experience, Language, Pictorial, Symbolic and Applications. This framework has been used in developing lessons and teacher professional programs in Indonesia since 2012 in cooperation with the World Bank. This paper describes the theory that underlines the framework in general and in relation to each inter-connected component. Two explicit learning sequences for classroom practice are described, associated with Pythagoras theorem and probability. This paper then concludes with recommendations for using ELPSA in various institutional contexts.

  2. WHC significant lessons learned 1993--1995

    Energy Technology Data Exchange (ETDEWEB)

    Bickford, J.C.

    1997-12-12

    A lesson learned as defined in DOE-STD-7501-95, Development of DOE Lessons Learned Programs, is: A ``good work practice`` or innovative approach that is captured and shared to promote repeat applications or an adverse work practice or experience that is captured and shared to avoid a recurrence. The key word in both parts of this definition is ``shared``. This document was published to share a wide variety of recent Hanford experiences with other DOE sites. It also provides a valuable tool to be used in new employee and continuing training programs at Hanford facilities and at other DOE locations. This manual is divided into sections to facilitate extracting appropriate subject material when developing training modules. Many of the bulletins could be categorized into more than one section, however, so examination of other related sections is encouraged.

  3. Rock slopes and reservoirs - lessons learned

    International Nuclear Information System (INIS)

    Moore, D.P.

    1999-01-01

    Lessons learned about slope stability in the course of four decades of monitoring, and in some cases stabilizing, slopes along British Columbia's hydroelectric reservoirs are discussed. The lessons are illustrated by short case histories of some of the more important slopes such as Little Chief Slide, Dutchman's Ridge, Downie Slide, Checkerboard Creek and Wahleach. Information derived from the monitoring and other investigations are compared with early interpretations of geology and slope performance. The comparison serves as an indicator of progress in slope stability determination and as a measure of the value of accumulated experience in terms of the potential consequences to safety and cost savings over the long life-span of hydroelectric projects.14 refs., 2 tabs., 15 figs

  4. Cryptography and the Internet: lessons and challenges

    Energy Technology Data Exchange (ETDEWEB)

    McCurley, K.S.

    1996-12-31

    The popularization of the Internet has brought fundamental changes to the world, because it allows a universal method of communication between computers. This carries enormous benefits with it, but also raises many security considerations. Cryptography is a fundamental technology used to provide security of computer networks, and there is currently a widespread engineering effort to incorporate cryptography into various aspects of the Internet. The system-level engineering required to provide security services for the Internet carries some important lessons for researchers whose study is focused on narrowly defined problems. It also offers challenges to the cryptographic research community by raising new questions not adequately addressed by the existing body of knowledge. This paper attempts to summarize some of these lessons and challenges for the cryptographic research community.

  5. A Lesson in Knitting [In Bulgarian

    Directory of Open Access Journals (Sweden)

    R. Pankova - Karadjova

    2016-11-01

    Full Text Available This is a non-fiction story about a grandmother teaching her six-year-old granddaughter how to knit. The child helps to wind the yarn into a ball and then patiently follows her granny's instructions, making stitch after stitch. The little girl's work is often uneven and is gently corrected. However, the small piece the child had knitted is used to patch up a tear in her grandfather's woolen glove. The lesson in knitting is transformed into a lesson in appreciation of one's work, no matter how small and insignificant it may seem. The narrative is permeated with the love between the grandmother and the child, who is the writer of the story.

  6. Material science lesson from the biological photosystem.

    Science.gov (United States)

    Kim, Younghye; Lee, Jun Ho; Ha, Heonjin; Im, Sang Won; Nam, Ki Tae

    2016-01-01

    Inspired by photosynthesis, artificial systems for a sustainable energy supply are being designed. Each sequential energy conversion process from light to biomass in natural photosynthesis is a valuable model for an energy collection, transport and conversion system. Notwithstanding the numerous lessons of nature that provide inspiration for new developments, the features of natural photosynthesis need to be reengineered to meet man's demands. This review describes recent strategies toward adapting key lessons from natural photosynthesis to artificial systems. We focus on the underlying material science in photosynthesis that combines photosystems as pivotal functional materials and a range of materials into an integrated system. Finally, a perspective on the future development of photosynthesis mimetic energy systems is proposed.

  7. TMI-2 lessons have been learned

    International Nuclear Information System (INIS)

    Long, R.L.

    1994-01-01

    This paper is an introduction to the more detailed papers which are presented in this session titled ''Advanced Light Water Reactors -- 15 Years After TMI.'' Many of the advances in the design, operation and maintenance of nuclear power plants are the direct result of applying lessons learned from the 1979 TMI-2 accident. The authors believe the ''reality awakening'' which occurred following the accident should never be forgotten. Thus, this paper briefly reviews the TMI-2 accident and identifies the broad lessons learned following the accident. Then it describes briefly some indicators which show the very impressive improvements in nuclear power plant performance that have occurred over the past 10-15 years. This sets the stage for Dr. Ransom's paper which shows the continuing need for nuclear power, Dr. Beckjord's paper which describes the ''final'' TMI-2 research project and the subsequent papers which focus on advanced light water reactor developments

  8. Osama bin Laden võib olla uues piiramisrõngas / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2004-01-01

    Briti ajakirjanduse andmeil on suudetud tuvastada bin Ladeni asukoht. 1993. aastal CIA peakorteri ees kaks USA luureagenti tapnud pakistanlase Mir Aimal Kasi ja bin Ladeni tagaotsimisest. Vt. samas: Taliban kogub uut jõudu

  9. Kas Osama plaanid on täitunud? / James Thurlow ; tõlk. Vappu Thurlow

    Index Scriptorium Estoniae

    Thurlow, James

    2007-01-01

    2001. aasta 11. septembri terrorirünnakute põhjustest ning bin Ladeni tegevuse eesmärkidest. Autori arvates ei ole al-Qaida hoolimata selle tugevatest külgedest oma filosoofiliste tõekspidamistega poliitilise võimu haaramiseks sobiv. Ameerika ja lääneriigid peaksid tunnistama, et efektiivseim relv on tolerantsus ja sellest tulenev respekt teiste vastu

  10. "I'm Not Really Afraid of Osama Bin Laden!" Fear of Terrorism in Dutch Children

    Science.gov (United States)

    Muris, Peter; Mayer, Birgit; van Eijk, Sandra; van Dongen, Marit

    2008-01-01

    We examined to what extent children in The Netherlands are affected by the threat of terrorism. For this purpose, a sample of school children living in Rotterdam or adjacent satellites (N = 216) completed a fear survey that included a number of terrorism-related items, and were confronted with ambiguous vignettes to measure threat-related…

  11. "i'm not really afraid of Osama Bin Laden!" fear of terrorism in dutch children

    NARCIS (Netherlands)

    P.E.H.M. Muris (Peter); B.N. Mayer (Birgit); S. van Eijk (Sandra); M. Dongen (Marit)

    2008-01-01

    textabstractWe examined to what extent children in The Netherlands are affected by the threat of terrorism. For this purpose, a sample of school children living in Rotterdam or adjacent satellites (N = 216) completed a fear survey that included a number of terrorism-related items, and were

  12. Speed, Acceleration, and Velocity: Level II, Unit 9, Lesson 1; Force, Mass, and Distance: Lesson 2; Types of Motion and Rest: Lesson 3; Electricity and Magnetism: Lesson 4; Electrical, Magnetic, and Gravitational Fields: Lesson 5; The Conservation and Conversion of Matter and Energy: Lesson 6; Simple Machines and Work: Lesson 7; Gas Laws: Lesson 8; Principles of Heat Engines: Lesson 9; Sound and Sound Waves: Lesson 10; Light Waves and Particles: Lesson 11; Program. A High.....

    Science.gov (United States)

    Manpower Administration (DOL), Washington, DC. Job Corps.

    This self-study program for high-school level contains lessons on: Speed, Acceleration, and Velocity; Force, Mass, and Distance; Types of Motion and Rest; Electricity and Magnetism; Electrical, Magnetic, and Gravitational Fields; The Conservation and Conversion of Matter and Energy; Simple Machines and Work; Gas Laws; Principles of Heat Engines;…

  13. Learning to observe mathematical learning in lesson studies

    DEFF Research Database (Denmark)

    Rasmussen, Klaus; Østergaard, Camilla Hellsten; Foss, Kristian Kildemoes

    2016-01-01

    This poster deals with lesson study (LS) in pre-service teacher education. In particular how to prepare for, carry out, and reflect upon, observations of pupil learning. Observation is of crucial importance to the lesson study process, and here we present a study of observation features which ena...... enable or hinder fruitful lesson study. While substantial research has been carried out in the general field of bserving pupils’ learning processes and teachers’ pedagogical practice, little is known about this in the particular setting of lesson study....

  14. Lessons Learned in Software Testing A Context-Driven Approach

    CERN Document Server

    Kaner, Cem; Pettichord, Bret

    2008-01-01

    Decades of software testing experience condensed into the most important lessons learned.The world's leading software testing experts lend you their wisdom and years of experience to help you avoid the most common mistakes in testing software. Each lesson is an assertion related to software testing, followed by an explanation or example that shows you the how, when, and why of the testing lesson. More than just tips, tricks, and pitfalls to avoid, Lessons Learned in Software Testing speeds you through the critical testing phase of the software development project without the extensive trial an

  15. Radiological Control Technician: Phase 1, Site academic training lesson plans

    International Nuclear Information System (INIS)

    1992-10-01

    This volume provides lesson plans for training radiological control technicians. Covered here is basic radiological documentation, counting errors, dosimetry, environmental monitoring, and radiation instruments

  16. Lessons Learned from Developing SAWA: A Situation Awareness Assistant

    National Research Council Canada - National Science Library

    Matheus, Christopher J; Kokar, Mieczyslaw M; Letkowski, Jerzy J; Call, Catherine; Baclawski, Kenneth; Hinman, Michael; Salerno, John; Boulware, Douglas

    2005-01-01

    .... During the process of its development several lessons were learned about advantages and limitations of certain approaches, techniques and technologies as they are applied to situation awareness...

  17. The lessons of Three Mile Island

    International Nuclear Information System (INIS)

    McKee, K.C.

    1990-01-01

    This article looks at the lessons learned from the Three Mile Island incident in 1979 from the perspective of the manager of public affairs for General Public Utilities. A review of what was done, the types of information presented, the interfaces to the press, public and local and state government and why it did not work is presented. The article addresses communications and crisis management

  18. Basic Lessons in *ORA and Automap 2009

    Science.gov (United States)

    2009-06-01

    screen capture showing the visualization of the agent x event graph from the Stargate Summit Meta-Network. The visualization displays the connections...for the Stargate dataset. 25.2 lessons - 201-207 A step by step run through of creating the Meta-Network from working with Excel, exporting data to...For the purpose of creating the Stargate MetaNetwork the two-episode story arc (Summit / Last Stand) was choosen as the basis for all the nodes

  19. Acquiring Procedural Skills from Lesson Sequences.

    Science.gov (United States)

    1985-08-13

    Teachers of Mathematics . Washington, D)C: NCTM . Brueckner, I..J. (1930) Diagnostic aund remedial teaching in arithmetic. Philadelphia. PA: Winston. Burton...arithmetic and algebra, fr-m multi-lesson curricula. The central hypothesis is that students and teachers obey cc: :-.entions that cause the goal hierarchy...students and • . teachers obey conventions that cause the goal hierarchy of the acquired procedure to be a particular structural function of the sequential

  20. The X-15 airplane - Lessons learned

    Science.gov (United States)

    Dana, William H.

    1993-01-01

    The X-15 rocket research airplane flew to an altitude of 354,000 ft and reached Mach 6.70. In almost 200 flights, this airplane was used to gather aerodynamic-heating, structural loads, stability and control, and atmospheric-reentry data. This paper describes the origins, design, and operation of the X-15 airplane. In addition, lessons learned from the X-15 airplane that are applicable to designing and testing the National Aero-Space Plane are discussed.

  1. The Joint Lessons Learned System and Interoperability

    Science.gov (United States)

    1989-06-02

    Learned: 1988-1989 As mentioned in the introduction to this chaoter, the Organizacion of the JcinC Chiefs cf Staff .OJCS) ueren significant transformatioi...Organization and Functions Manual . Washington, D.C.: HQDA, Office of the Deputy Chief 0f Staff for Operations and Plans, June 1984. ’..S. Army. Concept...U.S. Department of Defense. Joint Universal Lessons Learned System (JULLS) User’s Manual . Orlando, Florida: University of Central Florida, Institute

  2. CAT/RF Simulation Lessons Learned

    Science.gov (United States)

    2003-06-11

    IVSS-2003-MAS-7 CAT /RF Simulation Lessons Learned Christopher Mocnik Vetronics Technology Area, RDECOM TARDEC Tim Lee DCS Corporation...developed a re- configurable Unmanned Ground Vehicle (UGV) simulation for the Crew integration and Automation Test bed ( CAT ) and Robotics Follower (RF...Advanced Technology Demonstration (ATD) experiments. This simulation was developed as a component of the Embedded Simulation System (ESS) of the CAT

  3. Lessons learnt by US nuclear plant operators

    International Nuclear Information System (INIS)

    Hill, W.

    2007-01-01

    Transparency means to communicate to the constituents openly and honestly, as soon as appear credible information. The author deals the subject in four fold: experience in the United States that have taught how not to communicate about nuclear energy; the successfully apply of these lessons learned to subsequent events; the need for transparency reaffirmed by more recent events; ongoing efforts by the United States industry to strengthen the core principles of transparency. (A.L.B.)

  4. Job Oriented Training ’Lessons Learned’

    Science.gov (United States)

    2008-11-01

    Job Oriented Training ’Lessons Learned’ Job Oriented Training (JOT), een vorm van trainen waarbij de cursist zelfstandig, zonder theorie vooraf...39 77 lnfo-DenV@tno.nl TNO-rapportnummer TNO-DV 2008 A447 Opdrachtnummer Datum november 2008 Auteur (s) drs. H.E. Stubbe dr. A.H. van der...onderlinge discussie over achterliggende overwegingen te stimuleren. Zij hebben op dat moment nog geen theorie aangeboden gekregen en zijn niet op de hoogte

  5. Lessons learned in applying function analysis

    International Nuclear Information System (INIS)

    Mitchel, G.R.; Davey, E.; Basso, R.

    2001-01-01

    This paper summarizes the lessons learned in undertaking and applying function analysis based on the recent experience of utility, AECL and international design and assessment projects. Function analysis is an analytical technique that can be used to characterize and asses the functions of a system and is widely recognized as an essential component of a 'systematic' approach to design, on that integrated operational and user requirements into the standard design process. (author)

  6. Lessons learned from Spain's nuclear program

    International Nuclear Information System (INIS)

    Garcia Rodriguez, A.

    1993-01-01

    The commercial nuclear program in Spain dates back to the beginning of the 1960s. There are currently nine units in operation, one more has been decommissioned and a further five are in different phases of construction but under nuclear moratorium since 1983. This article gives a general overview of the program, the criteria applied, what it has meant to and required of the industry and, finally, what lessons have been learned. (author) 2 figs

  7. Organizational safety factors research lessons learned

    International Nuclear Information System (INIS)

    Ryan, T.G.

    1995-01-01

    This Paper reports lessons learned and state of knowledge gained from an organizational factors research activity involving commercial nuclear power plants in the United States, through the end of 1991, as seen by the scientists immediately involved in the research. Lessons learned information was gathered from the research teams and individuals using a question and answer format. The following five questions were submitted to each team and individual: (1) What organizational factors appear to influence safety performance in some systematic way, (2) Should organizational factors research focus at the plant level, or should it extend beyond the plant level to the parent company, rate setting commissions, regulatory agencies, (3) How important is having direct access to plants for doing organizational factors research, (4) What lessons have been learned to date as the result of doing organizational factors research in a nuclear regulatory setting, and (5) What organizational research topics and issues should be pursued in the future? Conclusions based on the responses provided for this report are that organizational factors research can be conducted in a regulatory setting and produce useful results. Technologies pioneered in other academic, commercial, and military settings can be adopted for use in a nuclear regulatory setting. The future success of such research depends upon the cooperation of regulators, contractors, and the nuclear industry

  8. Enhancing mathematics teachers' quality through Lesson Study.

    Science.gov (United States)

    Lomibao, Laila S

    2016-01-01

    The efficiency and effectivity of the learning experience is dependent on the teacher quality, thus, enhancing teacher's quality is vital in improving the students learning outcome. Since, the usual top-down one-shot cascading model practice for teachers' professional development in Philippines has been observed to have much information dilution, and the Southeast Asian Ministers of Education Organization demanded the need to develop mathematics teachers' quality standards through the Southeast Asia Regional Standards for Mathematics Teachers (SEARS-MT), thus, an intensive, ongoing professional development model should be provided to teachers. This study was undertaken to determine the impact of Lesson Study on Bulua National High School mathematics teachers' quality level in terms of SEARS-MT dimensions. A mixed method of quantitative-qualitative research design was employed. Results of the analysis revealed that Lesson Study effectively enhanced mathematics teachers' quality and promoted teachers professional development. Teachers positively perceived Lesson Study to be beneficial for them to become a better mathematics teacher.

  9. Research Data Curation Pilots: Lessons Learned

    Directory of Open Access Journals (Sweden)

    David Minor

    2014-07-01

    Full Text Available In the spring of 2011, the UC San Diego Research Cyberinfrastructure (RCI Implementation Team invited researchers and research teams to participate in a research curation and data management pilot program. This invitation took the form of a campus-wide solicitation. More than two dozen applications were received and, after due deliberation, the RCI Oversight Committee selected five curation-intensive projects. These projects were chosen based on a number of criteria, including how they represented campus research, varieties of topics, researcher engagement, and the various services required. The pilot process began in September 2011, and will be completed in early 2014. Extensive lessons learned from the pilots are being compiled and are being used in the on-going design and implementation of the permanent Research Data Curation Program in the UC San Diego Library. In this paper, we present specific implementation details of these various services, as well as lessons learned. The program focused on many aspects of contemporary scholarship, including data creation and storage, description and metadata creation, citation and publication, and long term preservation and access. Based on the lessons learned in our processes, the Research Data Curation Program will provide a suite of services from which campus users can pick and choose, as necessary. The program will provide support for the data management requirements from national funding agencies.

  10. Low level waste shipment accident lessons learned

    International Nuclear Information System (INIS)

    Rast, D.M.; Rowe, J.G.; Reichel, C.W.

    1995-01-01

    On October 1, 1994 a shipment of low-level waste from the Fernald Environmental Management Project, Fernald, Ohio, was involved in an accident near Rolla, Missouri. The accident did not result in the release of any radioactive material. The accident did generate important lessons learned primarily in the areas of driver and emergency response communications. The shipment was comprised of an International Standards Organization (ISO) container on a standard flatbed trailer. The accident caused the low-level waste package to separate from the trailer and come to rest on its top in the median. The impact of the container with the pavement and median inflicted relatively minor damage to the container. The damage was not substantial enough to cause failure of container integrity. The success of the package is attributable to the container design and the packaging procedures used at the Fernald Environmental Management Project for low-level waste shipments. Although the container survived the initial wreck, is was nearly breached when the first responders attempted to open the ISO container. Even though the container was clearly marked and the shipment documentation was technically correct, this information did not identify that the ISO container was the primary containment for the waste. The lessons learned from this accident have DOE complex wide applicability. This paper is intended to describe the accident, subsequent emergency response operations, and the lessons learned from this incident

  11. Safety and Mission Assurance for In-House Design Lessons Learned from Ares I Upper Stage

    Science.gov (United States)

    Anderson, Joel M.

    2011-01-01

    This viewgraph presentation identifies lessons learned in the course of the Ares I Upper Stage design and in-house development effort. The contents include: 1) Constellation Organization; 2) Upper Stage Organization; 3) Presentation Structure; 4) Lesson-Importance of Systems Engineering/Integration; 5) Lesson-Importance of Early S&MA Involvement; 6) Lesson-Importance of Appropriate Staffing Levels; 7) Lesson-Importance S&MA Team Deployment; 8) Lesson-Understanding of S&MA In-Line Engineering versus Assurance; 9) Lesson-Importance of Close Coordination between Supportability and Reliability/Maintainability; 10) Lesson-Importance of Engineering Data Systems; 11) Lesson-Importance of Early Development of Supporting Databases; 12) Lesson-Importance of Coordination with Safety Assessment/Review Panels; 13) Lesson-Implementation of Software Reliability; 14) Lesson-Implementation of S&MA Technical Authority/Chief S&MA Officer; 15) Lesson-Importance of S&MA Evaluation of Project Risks; 16) Lesson-Implementation of Critical Items List and Government Mandatory Inspections; 17) Lesson-Implementation of Critical Items List Mandatory Inspections; 18) Lesson-Implementation of Test Article Safety Analysis; and 19) Lesson-Importance of Procurement Quality.

  12. 毛奇龄评点《西厢记》的叙事论%Narrative Theory of Mao Qiling’s Commentaries on Romance ofWest Chamber

    Institute of Scientific and Technical Information of China (English)

    杨绪容

    2016-01-01

    毛奇龄的《西厢记》论释处于继王骥德和凌初以来《西厢记》学术性评点的顶端,其叙事论实可与金圣叹的叙事论双峰并立于清代戏曲评点史上。毛氏评点虽亦兴之所至,率性而发,但通读全篇则不难发现其系统性、理论性。如论叙事视角之“旁观”、叙事内容之“转变”、叙事照应之“暗度金针”、叙事节奏之“抑扬顿挫”,无一不体现毛氏的独到见解。其叙事论又可与西方现代叙事学相通。毛氏论析的叙述层次、叙事视角、叙事照应、叙事节奏、叙事方法,大致涵盖了现代叙事学的叙述人、叙事时间、叙事方法等范畴。梳理毛奇龄评点《西厢记》的叙事论,有助于构建古代叙事学与现代叙事学的内在关联,为中国叙事学固本培根。%Mao Qiling’s academic commentaries on Romance ofWest Chamber have been deemed among the best since Wang Jide’s and Ling Mengchu’s commentaries.His narrative theory juxtaposed with Jin Sheng-tan’s as the best two in the history of drama commentary in Qing Dynasty.Mao’s commentaries are spontane-ous and candid on the spur of moment,yet systematic and theoretical if read holistically.For instances,the narrative perspective as“an onlooker”in term of narrative perspective,“twists and turns”in terms of narrative contents,“exquisite foreshadowing”in terms of narrative correlation and “rising and falling tones”in terms of narrative rhythm,all have shown Mao’s distinctive opinions.Mao’s narrative theory is in agreement with west-ern modern narratology in that Mao’s narrative layers,perspectives,correlations and methods generally include such categories as narrators,narrative time,narrative methods in modern narratology.The study of Mao’s nar-rative theory in the perspective of his commentaries on Romance ofWest Chamber can help construct the internal correlation between ancient and modern narratology

  13. Discovering Euler Circuits and Paths through a Culturally Relevant Lesson

    Science.gov (United States)

    Robichaux, Rebecca R.; Rodrigue, Paulette R.

    2006-01-01

    This article describes a middle school discrete mathematics lesson that uses the context of catching crawfish to provide students with a hands-on experience related to Euler circuits and paths. The lesson promotes mathematical communication through the use of cooperative learning as well as connections between mathematics and the real world…

  14. Why Lesson Study Works in Japan: A Cultural Perspective

    Science.gov (United States)

    Ebaeguin, Marlon; Stephens, Max

    2014-01-01

    Japanese lesson study has attracted many international educators who have been impressed by its capacity to foster student learning and sustained professional growth of teachers. This paper reports a study on its cultural orientations that may explain why lesson study works seamlessly in Japan. Hofstede's dimensions of national culture are…

  15. World Hunger: Famine in Africa. Sample Lessons, Secondary.

    Science.gov (United States)

    Neeson, Eileen; And Others

    This model social studies lesson includes a simulated interview with a relief worker describing the famine conditions in Ethiopia. A map of Africa and pictures of famine victims are included. The objectives of the lesson are to have students describe the situation in Ethiopia, analyze the causes, and evaluate solutions to the famine. In the model…

  16. Integrating UNESCO ICT-Based Instructional Materials in Chemistry Lessons

    Directory of Open Access Journals (Sweden)

    CHARLIE P. NACARIO

    2014-08-01

    Full Text Available This study determined the effectiveness of the lessons in Chemistry integrating UNESCO ICT-based instructional material on the achievement of Chemistry students at Central Bicol State University of Agriculture. It aimed to identify lessons that may be developed integrating UNESCO ICT-based instructional materials, determine the effect of the developed lessons using the material on: conceptual understanding; science process skills; and attitude towards chemistry and gather insights from the experiences of the students and teacher. The study used the single group pretest and posttest experimental design. Descriptive, quantitative and qualitative techniques were also utilized. Quantitative data were taken from the pretest-posttest results on the Test on Conceptual Understanding, Science Process Skills and Chemistry Attitudinaire. Qualitative data were drawn from the experts’ assessment of the developed lessons and research instruments, and the insights of students and teacher. The developed lessons integrating UNESCO ICT-based instructional materials were Atomic Model and Structure, Periodic Table of Elements, Chemical Bonding, and Balancing Chemical Equation. These lessons increased the conceptual understanding of the students by topic and skill from very low mastery to average mastery level. The students have slightly improved along the different science process skills. After teaching the lessons, the students’ attitude also improved. The students became more motivated and interested in Chemistry and the lessons were student centered and entailed teacher’s competence and flexibility in computer use.

  17. From inventivity in Limerick to creativity in Aveiro: lessons learnt

    CSIR Research Space (South Africa)

    Wong, W

    2009-01-01

    Full Text Available This paper describes the key lessons from an earlier HCI Educators’ conference, held in Limerick in 2006, the outcomes of which led to the theme of HCIEd 2007 – Creativity: Experiencing to Educate and Design. The paper discusses the lessons leant...

  18. Moroccan Arabic Technical Lessons for Rehab./Special Ed.

    Science.gov (United States)

    Chtatou, Mohamed, Ed.

    The instructional materials in Moroccan Arabic are designed to meet the language needs of Peace Corps volunteers working in rehabilitation and special education in Morocco. The lessons are almost entirely in Arabic, and include vocabulary lists with both technical and everyday language pertaining to disabilities. Lesson topics include singing, the…

  19. The Finishing Touch: Anatomy of Expert Lesson Closures

    Science.gov (United States)

    Webster, Collin A.; Connolly, Graeme; Schempp, Paul G.

    2009-01-01

    Background: Based on the idea that students remember best what is presented last, the lesson closure is commonly identified as an important component of effective teaching and has recently surfaced as a routine practice of expert teachers in sport. Despite its link to both effective and expert instruction, the lesson closure has seen scarce…

  20. Lessons of History: Organizational Factors in Three Aviation Mishaps

    Science.gov (United States)

    Merlin, Peter William

    2013-01-01

    This presentation examines organizational factors that contributed to three aircraft mishaps and provides analysis of lessons learned. Three historical aviation mishaps were studied from a human factors perspective, and organizational factors identified and analyzed. These case studies provide valuable lessons for understanding the interaction of people with aircraft systems and with each other during flight operations.

  1. "Connecting the Dots": Munich, Iraq, and the Lessons of History

    Science.gov (United States)

    Conolly-Smith, Peter

    2009-01-01

    This paper seeks to explore the ways in which "lessons of history," in particular the "Munich analogy," have been misconstrued in justification of United States armed intervention since the beginning of the Cold War. While the wisdom of a hawkish foreign policy is indeed one lesson of Munich--certainly as applied to World War…

  2. "Hamlet" Meets "Chushingura": Traditions of the Revenge Tragedy. [Lesson Plan].

    Science.gov (United States)

    2002

    This lesson seeks to sensitize students to the similarities and difference between cultures by comparing the Shakespearean and the Bunraki/Kabuki dramas of Japan. In the lesson, the focus of this comparison is the complex nature of revenge explored in "The Tragedy of Hamlet, Prince of Denmark" and "Chusingura," or "The…

  3. Gross Domestic Pizza. Active Learning Lessons. Economics International.

    Science.gov (United States)

    Zaleskiene, Irena; Venger, Anatoly; MacDonald, Rich; Davis, Debbie

    This lesson plan was developed through "Economics International," an international program to help build economic education infrastructures in the emerging market economies. It provides a lesson description; appropriate age level; economic concepts; content standards and benchmarks; related subject areas; instructional objectives; time…

  4. Go West: Imagining the Oregon Trail. [Lesson Plan].

    Science.gov (United States)

    National Endowment for the Humanities (NFAH), Washington, DC.

    In this lesson plan, students in grades 3-5 compare imagined travel experiences of their own with the actual experiences of 19th-century pioneers on the Oregon Trail. After the 4 lessons students will have: (1) learned about the pioneer experience on the Oregon Trail; (2) compared and contrasted modern-day travel experiences with those of the 19th…

  5. Students' perception of mathematics and science plasma lessons in ...

    African Journals Online (AJOL)

    ... to follow the lessons appropriately. Moreover, on regular basis the ministry of education should make appropriate mechanisms for the improvements of the lessons. In addition to this, trainings should be given to high school teachers for maximum utilization of the technology. Keywords: education, plasma TV, mathematics, ...

  6. Mathematics Teachers' Views of Accountability Testing Revealed through Lesson Study

    Science.gov (United States)

    Yarema, Connie H.

    2010-01-01

    The practice of lesson study, a professional development model originating in Japan, aligns well with recommendations from research for teacher professional development. Lesson study is also an inductive research method that uncovers student thinking and, in parallel, grants teacher-educators the opportunity to study teachers' thinking about…

  7. Lessons learned from AU PSO-missions in Africa

    DEFF Research Database (Denmark)

    Mandrup, Thomas

    The paper deals with the lessons learned from AU's PSO since 2002, and what that entails for the design of future PSO.......The paper deals with the lessons learned from AU's PSO since 2002, and what that entails for the design of future PSO....

  8. The Paper Airplane Challenge: A Market Economy Simulation. Lesson Plan.

    Science.gov (United States)

    Owens, Kimberly

    This lesson plan features a classroom simulation that helps students understand the characteristics of a market economic system. The lesson plan states a purpose; cites student objectives; suggests a time duration; lists materials needed; and details a step-by-step teaching procedure. The "Paper Airplane Challenge" handout is attached. (BT)

  9. "O Mundo da Lingua Portuguesa," a Supplementary Cultural Lesson.

    Science.gov (United States)

    Kennedy, James H.

    The text of a classroom lesson on the distribution and use of the Portuguese language in African countries, written in Portuguese and containing an explanation of and practice in using the definite article with African place names, is presented. The lesson is accompanied by vocabulary notes in the margin, a list of questions on the text, and a mpa…

  10. Righting Your Future: LRE Lesson Plans for Today and Tomorrow.

    Science.gov (United States)

    CRADLE: Center for Research and Development in Law-Related Education, Winston-Salem, NC.

    A compilation of more than 50 lesson plans on law related education, these materials were written by middle school and high school teachers from around the United States. The lessons cover a broad range of topics including "DNA Fingerprints and the Constitutional Right to Privacy"; "Censorship and Book Banning in Public Schools"; "The Death…

  11. Exploring Ethograms in the Schoolyard: A Lesson on Animal Behavior

    Science.gov (United States)

    Graszer, Christina L.; Gnau, Katie; Melber, Leah M.

    2012-01-01

    This article highlights a core lesson that has been used in a number of Lincoln Park Zoo educational programs. The lesson teaches students to conduct an ethological, or animal behavior, study on a bird. This study can be implemented in a variety of outdoor settings, including a park, schoolyard, or zoo. Using an ethogram, students will practice…

  12. The Construction of Biology Lessons: A Meta-Paradigmatic Approach.

    Science.gov (United States)

    Sanchez, Jaime

    1991-01-01

    The views of Piaget, Ausubel, and Bruner have been used to present an integrated view of biology lesson construction and to assist teachers in the design and development of tools and strategies to improve their teaching. The structure of an integrated model for biology lesson construction and an example of a biolesson using the metaparadigmatic…

  13. Development of an Attitude Scale towards High School Physics Lessons

    Science.gov (United States)

    Yavas, Pervin Ünlü; Çagan, Sultan

    2017-01-01

    The aim of this study was to develop a Likert type attitude scale for high school students with regard to high school physics lessons. The research was carried out with high school students who were studying in Ankara. First, the opinions of 105 high school students about physics lessons were obtained and then 55 scale items were determined from…

  14. Lessons Learnt on Rain Forest Management for Wood Production in ...

    African Journals Online (AJOL)

    The study was carried out with the aim of analyzing and establishing what lessons have been learnt from positive and negative experiences of various initiatives, projects and programmes aiming at sustainable management, use and conservation of rain forests in Sub-Saharan Africa. The lessons learnt from the case ...

  15. Defense Language Institute Russian Basic Course. Volumes XXVIII, Lessons 131-140. Volume XXX, Lessons 151-159.

    Science.gov (United States)

    Defense Language Inst., Washington, DC.

    The 19 lessons in these two volumes are intended for the advanced phase of a 159-lesson intensive audiolingual basic Russian course developed recently by the Defense Language Institute to train native speakers of English to a Level 3 second language proficiency. These third and fifth volumes contain such features as (1) texts on the Russian Civil…

  16. A Model of Microteaching Lesson Study Implementation in the Prospective History Teacher Education

    Science.gov (United States)

    Utami, Indah Wahyu Puji; Mashuri; Nafi'ah, Ulfatun

    2016-01-01

    Microteaching lesson study is a model to improve prospective teacher quality by incorporating several element of microteaching and lesson study. This study concern on the implementation of microteaching lesson study in prospective history teacher education. Microteaching lesson study model implemented in this study consist of three stages: plan,…

  17. Driver. D530.2 – Tools for the Lessons Learned Framework

    NARCIS (Netherlands)

    Schaik, M.G. van; et al

    2016-01-01

    In this deliverable D530.2 “Tools for the Lessons Learned Framework” the overall lessons learned framework will be clarified based on the delivery D53.1 “Lessons Learned Framework Concept” and aligned with the deliverable D52.1 “Harmonized competence framework”. The Tools for the Lessons Learned

  18. Lessons learned from MONJU sodium leak accident

    International Nuclear Information System (INIS)

    Nakai, Ryodai; Ito, Kazumoto; Nagata, Takashi

    2000-01-01

    MONJU sodium leak accident was a small accident with a large public impact. There was no injures or exposure to radiation, nor was there any loss of safety function such as reactor shutdown or reactor cooling. On the contrary a social impact is considerably large, whereby the plant remains shutdown. This paper describes the lessons learned from the accident, i.e. the impact of the accident and its cause, and the features on risk management in view of social aspect as well as technical aspect. (author)

  19. A Lesson Plan Incorporating Collaborative Strategic Reading

    Institute of Scientific and Technical Information of China (English)

    陈江萍

    2017-01-01

    This essay is going to have an in-depth analysis of the Collaborative Strategic Reading, a four-step reading comprehen-sion strategy popular in the Western classrooms. It will start with some brief introduction about this instructional approach in company with its theoretical rationale and research evidence for its effectiveness of improving learners 'reading competence. Fo-cused on the previewing skill, the first step of the reading instruction, a modified lesson plan is designed in the Chinese high school setting, followed by justification of the major elements of the plan, and some practical implications.

  20. A Lesson Plan Incorporating Collaborative Strategic Reading

    Institute of Scientific and Technical Information of China (English)

    陈江萍

    2017-01-01

    This essay is going to have an in-depth analysis of the Collaborative Strategic Reading, a four-step reading comprehen?sion strategy popular in the Western classrooms. It will start with some brief introduction about this instructional approach in company with its theoretical rationale and research evidence for its effectiveness of improving learners 'reading competence. Fo?cused on the previewing skill, the first step of the reading instruction, a modified lesson plan is designed in the Chinese high school setting, followed by justification of the major elements of the plan, and some practical implications.

  1. Worldwide market developments : lessons for Alberta

    International Nuclear Information System (INIS)

    Percival, J.F.

    1998-01-01

    A review of competitive retail electricity markets in Argentina, New Zealand, Australia and California were discussed, highlighting lessons for Alberta policy makers, market designers and electricity retailers. Some of the emerging strategies in the retail electricity marketplace such as horizontal integration, generation retailing, defensive retailing and virtual vertical integration were explored. Emphasis was on showing that electricity retailing is not an easy business. It is a business for large and existing players, and although horizontal and vertical integration have growth and profit potential, there are also risks

  2. The Fernald Closure Project: Lessons Learned

    International Nuclear Information System (INIS)

    Murphy, Cornelius M.; Carr, Dennis

    2008-01-01

    For nearly 37 years, the U.S. Department of Energy site at Fernald - near Cincinnati, Ohio - produced 230,000 metric tons (250,000 short tons) of high-purity, low-enriched uranium for the U.S. Defense Program, generating more than 5.4 million metric tons (6 million short tons) of liquid and solid waste as it carried out its Cold War mission. The facility was shut down in 1989 and clean up began in 1992, when Fluor won the contract to clean up the site. Cleaning up Fernald and returning it to the people of Ohio was a $4.4 billion mega environmental-remediation project that was completed in October 2006. Project evolved through four phases: - Conducting remedial-investigation studies to determine the extent of damage to the environment and groundwater at, and adjacent to, the production facilities; - Selecting cleanup criteria - final end states that had to be met that protect human health and the environment; - Selecting and implementing the remedial actions to meet the cleanup goals; - Executing the work in a safe, compliant and cost-effective manner. In the early stages of the project, there were strained relationships - in fact total distrust - between the local community and the DOE as a result of aquifer contamination and potential health effects to the workers and local residents. To engage citizens and interested stakeholders groups in the decision-making process, the DOE and Fluor developed a public-participation strategy to open the channels of communication with the various parties: site leadership, technical staff and regulators. This approach proved invaluable to the success of the project, which has become a model for future environmental remediation projects. This paper will summarize the history and shares lessons learned: the completion of the uranium-production mission to the implementation of the Records of Decision defining the cleanup standards and the remedies achieved. Lessons learned fall into ten categories: - Regulatory approach with end

  3. Lessons Learned from Environmental Remediation Programmes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-03-15

    Several remediation projects have been developed to date, and experience with these projects has been accumulated. Lessons learned span from non-technical to technical aspects, and need to be shared with those who are beginning or are facing the challenge to implement environmental remediation works. This publication reviews some of these lessons. The key role of policy and strategies at the national level in framing the conditions in which remediation projects are to be developed and decisions made is emphasized. Following policy matters, this publication pays attention to the importance of social aspects and the requirement for fairness in decisions to be made, something that can only be achieved with the involvement of a broad range of interested parties in the decision making process. The publication also reviews the funding of remediation projects, planning, contracting, cost estimates and procurement, and issues related to long term stewardship. Lessons learned regarding technical aspects of remediation projects are reviewed. Techniques such as the application of cover systems and soil remediation (electrokinetics, phytoremediation, soil flushing, and solidification and stabilization techniques) are analysed with respect to performance and cost. After discussing soil remediation, the publication covers issues associated with water treatment, where techniques such as ‘pump and treat’ and the application of permeable barriers are reviewed. Subsequently, there is a section dedicated to reviewing briefly the lessons learned in the remediation of uranium mining and processing sites. Many of these sites throughout the world have become orphaned, and are waiting for remediation. The publication notes that little progress has been made in the management of some of these sites, particularly in the understanding of associated environmental and health risks, and the ability to apply prediction to future environmental and health standards. The publication concludes

  4. Lessons, open questions, and future prospects

    Directory of Open Access Journals (Sweden)

    Grupe D.

    2012-12-01

    Full Text Available We summarize some of the highlights of this workshop, the first of its kind dedicated to observing and modeling the tidal disruption of stars by black holes in the centers of galaxies (or star clusters. We review the lessons learned from recent observations and from theory and identify outstanding questions and areas where more theoretical and observational work is needed. We also consider upcoming observing facilities that can be used to study tidal disruption events and speculate what these new facilities may contribute to the field.

  5. [Lessons from a heart valve prosthesis controversy].

    Science.gov (United States)

    Vandenbroucke, J P; Grobbee, D E

    1998-07-18

    Two lessons are to be learnt from the Björk-Shiley heart valve prosthesis tragedy. In the first place pharmacoepidemiologic studies are seriously hampered by recent privacy legislation. Individual patients carrying such a prosthesis cannot be traced and advised as to their health risks any more, because their legal autonomy has to be respected. This is clearly not to their advantage. In the second place the atmosphere of marketing and litigation and the increasing dependency of researchers on money from sources with conflicting interests is not conducive to a well-informed and balanced judgement of the epidemiological evidence of safety and efficacy of medical treatments.

  6. Lessons Learned from Environmental Remediation Programmes

    International Nuclear Information System (INIS)

    2014-01-01

    Several remediation projects have been developed to date, and experience with these projects has been accumulated. Lessons learned span from non-technical to technical aspects, and need to be shared with those who are beginning or are facing the challenge to implement environmental remediation works. This publication reviews some of these lessons. The key role of policy and strategies at the national level in framing the conditions in which remediation projects are to be developed and decisions made is emphasized. Following policy matters, this publication pays attention to the importance of social aspects and the requirement for fairness in decisions to be made, something that can only be achieved with the involvement of a broad range of interested parties in the decision making process. The publication also reviews the funding of remediation projects, planning, contracting, cost estimates and procurement, and issues related to long term stewardship. Lessons learned regarding technical aspects of remediation projects are reviewed. Techniques such as the application of cover systems and soil remediation (electrokinetics, phytoremediation, soil flushing, and solidification and stabilization techniques) are analysed with respect to performance and cost. After discussing soil remediation, the publication covers issues associated with water treatment, where techniques such as ‘pump and treat’ and the application of permeable barriers are reviewed. Subsequently, there is a section dedicated to reviewing briefly the lessons learned in the remediation of uranium mining and processing sites. Many of these sites throughout the world have become orphaned, and are waiting for remediation. The publication notes that little progress has been made in the management of some of these sites, particularly in the understanding of associated environmental and health risks, and the ability to apply prediction to future environmental and health standards. The publication concludes

  7. HCI Lessons From PlayStation VR

    OpenAIRE

    Habgood, Jacob; Wilson, David; Moore, David; Alapont, Sergio

    2017-01-01

    PlayStation VR has quickly built up a significant user-base of over a million headsets and its own ecosystem of games across a variety of genres. These games form part of a rapidly evolving testing ground for design solutions which can usefully inform HCI design for virtual reality. This paper reviews every PlayStation VR title released in the first three months of its lifecycle in order to identify emerging themes for locomotion. These themes are discussed with respect to the lessons learned...

  8. Lessons learnt from the organ retention controversy

    International Nuclear Information System (INIS)

    Madden, D.

    2009-01-01

    This paper examines the lessons to be learnt from the organ retention controversy in the Republic of Ireland. The paper emphasises the importance of good communication between clinicians and families of deceased persons and a move away from a medical culture based on paternalism to a partnership approach between clinicians and patients based on mutual trust and understanding. A model of authorisation rather than consent is proposed as the way forward for dealing with the difficult and traumatic experience of asking families for permission to carry out a post mortem examination on their deceased child. (authors)

  9. Free Trade and Tariffs: Level III, Unit 2, Lesson 1; Capitalism, Communism, Socialism: Lesson 2; Nationalism vs. Internationalism: Lesson 3. Advanced General Education Program. A High School Self-Study Program.

    Science.gov (United States)

    Manpower Administration (DOL), Washington, DC. Job Corps.

    This self-study program for high-school level contains lessons on: Free Trade and Tariffs; Capitalism, Communism, Socialism; and Nationalism vs. Internationalism. Each of the lessons concludes with a Mastery Test to be completed by the student. (DB)

  10. Plants and Photosynthesis: Level III, Unit 3, Lesson 1; The Human Digestive System: Lesson 2; Functions of the Blood: Lesson 3; Human Circulation and Respiration: Lesson 4; Reproduction of a Single Cell: Lesson 5; Reproduction by Male and Female Cells: Lesson 6; The Human Reproductive System: Lesson 7; Genetics and Heredity: Lesson 8; The Nervous System: Lesson 9; The Glandular System: Lesson 10. Advanced General Education Program. A High School Self-Study Program.

    Science.gov (United States)

    Manpower Administration (DOL), Washington, DC. Job Corps.

    This self-study program for the high-school level contains lessons in the following subjects: Plants and Photosynthesis; The Human Digestive System; Functions of the Blood; Human Circulation and Respiration; Reproduction of a Single Cell; Reproduction by Male and Female Cells; The Human Reproductive System; Genetics and Heredity; The Nervous…

  11. CLIL in physics lessons at grammar school

    Science.gov (United States)

    Štefančínová, Iveta; Valovičová, Ľubomíra

    2017-01-01

    Content and Language Integrated Learning (CLIL) is one of the most outstanding approaches in foreign language teaching. This teaching method has promising prospects for the future of modern education as teaching subject and foreign languages are combined to offer a better preparation for life in Europe, especially when the mobility is becoming a highly significant factor of everyday life. We realized a project called Foreign languages in popularizing science at grammar school. Within the project five teachers with approbation subjects of English, French, German and Physics attended the methodological courses abroad. The teachers applied the gained experience in teaching and linking science teaching with the teaching of foreign languages. Outputs of the project (e.g. English-German-French-Slovak glossary of natural science terminology, student activity sheets, videos with natural science orientation in a foreign language, physical experiments in foreign languages, multimedia fairy tales with natural contents, posters of some scientists) are prepared for the CLIL-oriented lessons. We collected data of the questionnaire for students concerning attitude towards CLIL. The questionnaire for teachers showed data about the attitude, experience, and needs of teachers employing CLIL in their lessons.

  12. Lessons learned from accidents in radiotherapy

    International Nuclear Information System (INIS)

    Ortiz-Lopez, P.; Haywood, J.

    1996-01-01

    Radiotherapy is the only application of radiation which intentionally delivers very high doses to humans. A gross deviation from the prescribed dose or dose distribution can have severe, or even fatal consequences. Since the patient is placed directly in the beam or sources are inserted in the body, any mistake made with the beam or the sources leads almost certainly to an accidental exposure. Lessons learned from previous incidents can be used to test the vulnerability of a given facility, provided that these are adequately disseminated. The purpose of this paper is to present a summary of the lessons learned from a relatively large sample of events. The analysis has been presented as a short description followed by an identification of the triggering event and the contributing factors. These have been grouped as follows: errors in commissioning or calibration machines and sources affecting many patients; mistakes affecting individual patients such as irradiating the wrong patient, the wrong, field or site, and mistakes when entering data into or reading from the patient's chart; error due to unusual treatments or situations; equipment failure and human machine problems, including maintenance. (author). 1 ref

  13. Arms control: moral, political and historical lesson

    International Nuclear Information System (INIS)

    Thompson, K.W.

    1990-01-01

    Many of the world's most influential policy-makers and analysts view arms control as a scientific and technological problem. They measure a nation's nuclear power exclusively by megatonnage and throw-weights leaving the intangible elements of military and political power to philosophers and historians. They tend to ignore the human and qualitative aspects of power. This is a book that shift the emphasis to aspects of the nuclear problem which are sometimes overlooked. Basically, these elements are bound up in the moral, political, and historical lessons of the nuclear age. Nonquantitative factors have been central to studies of national defense and military power since the rise of the modern nation state system. However, most students of present-day nuclear weapons tend to stress their revolutionary character. Because they are considered wholly unique, analysts tend to write about them in a historical and apolitical terms. One purpose of the collection of papers in this little volume is to redirect attention to the moral, political, and historical lessons that the nuclear age presents. What most distinguishes the writings of contributors to this volume is their use of certain well-established principles and concepts long acknowledged in military and foreign policy analysis. Thus Father Hehir asks many of the same questions that students of ethics and foreign policy have asked for four hundred years

  14. Dynasting Theory: Lessons in learning grounded theory

    Directory of Open Access Journals (Sweden)

    Johnben Teik-Cheok Loy, MBA, MTS, Ph.D.

    2011-06-01

    Full Text Available This article captures the key learning lessons gleaned from the author’s experience learning and developing a grounded theory for his doctoral dissertation using the classic methodology as conceived by Barney Glaser. The theory was developed through data gathered on founders and successors of Malaysian Chinese family-own businesses. The main concern for Malaysian Chinese family businesses emerged as dynasting . the building, maintaining, and growing the power and resources of the business within the family lineage. The core category emerged as dynasting across cultures, where founders and successors struggle to transition from traditional Chinese to hybrid cultural and modernized forms of family business from one generation to the next. The key learning lessons were categorized under five headings: (a sorting through different versions of grounded theory, (b educating and managing research stakeholders, (c embracing experiential learning, (d discovering the core category: grounded intuition, and (e recognizing limitations and possibilities.Keywords: grounded theory, learning, dynasting, family business, Chinese

  15. Governing nanobiotechnology: lessons from agricultural biotechnology regulation

    International Nuclear Information System (INIS)

    Johnson, Robbin S.

    2011-01-01

    This article uses lessons from biotechnology to help inform the design of oversight for nanobiotechnology. Those lessons suggest the following: first, oversight needs to be broadly defined, encompassing not just regulatory findings around safety and efficacy, but also public understanding and acceptance of the technology and its products. Second, the intensity of scrutiny and review should reflect not just risks but also perceptions of risk. Finally, a global marketplace argues for uniform standards or commercially practical solutions to differences in standards. One way of designing oversight to achieve these purposes is to think about it in three phases—precaution, prudence, and promotion. Precaution comes early in the technology or product’s development and reflects real and perceived uncertainties. Prudence governs when risks and hazards have been identified, containment approaches established, and benefits broadly defined. Transparency and public participation rise to the fore. The promotional phase moves toward shaping public understanding and acceptance and involves marketing issues rather than safety ones. This flexible, three-phase approach to oversight would have avoided some of the early regulatory problems with agricultural biotechnology. It also would have led to a more risk-adjusted pathway to regulatory approval. Furthermore, it would avoid some of the arbitrary, disruptive marketing issues that have arisen.

  16. 10 lessons learned by a misguided physician.

    Science.gov (United States)

    Levin, Barry E

    2017-07-01

    It was a great and humbling honor to receive the 2016 Distinguished Career Award from my SSIB colleagues. This paper summarizes the major points of my DCA talk at the 2016 annual meeting. It is a reflection on my 50year medical and research career and 10 lessons I have learned over those years which might be of help to young investigators near the beginning of their own research careers. These lessons include: the value of being receptive to the opportunities provided you; how clinician-scientists can serve as critical role models for young investigators like me and a history of how my career developed as a result of their influence; the importance of carefully examining your own data, particularly when it doesn't agree with your preconceived ideas; the critical role that students, postdocs and PhD (and even veterinarian) colleagues can play in developing one's career; the likelihood that your career path will have many interesting twists and turns determined by changes in your own scientific interests and how rewarding various areas of research focus are to you; the importance of building a close-knit laboratory staff family; the fact that science and romance can mix. Finally, I offer 3 somewhat self-evident free pieces of advice for building and maintaining a rewarding career. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Lessons learned on stakeholder issues in decommissioning

    International Nuclear Information System (INIS)

    O'Sullivan, P.; Pescatore, C.

    2008-01-01

    Issues of public concern during decommissioning and dismantling (D and D) are partly the same and partly different from those of the preceding phases (planning, construction and operation). While in the course of construction and operation the main challenges include meeting expectations of a higher quality of life, accommodating a growing population, mitigating construction nuisances, and assuring the safe operation of the facility, the main concerns in the D and D phase are decreasing employment rate, the eventual reduction of revenues for the municipality, the future use of the affected land and negative social impacts (e.g., out-migration). The decommissioning phase is characterised by heterogeneity of stakeholder interests and values, difficulties of reaching consensus or compromise, and difficulties in connection with the harmonization of energy production, environmental protection and sustainable socio-economic development considerations. Typically, there might also be tensions between local and regional decisions. As in other phases, the building of trust between stakeholder is crucial from the point of view of conflict management, and social lessons learnt from the siting and developments of nuclear facilities are widely applicable in the field of D and D as well. A review is presented of major lessons to be learnt from NEA activities in the field of decommissioning and stakeholder involvement. (author)

  18. Lessons learned on stakeholder issues in decommissioning

    Energy Technology Data Exchange (ETDEWEB)

    O' Sullivan, P.; Pescatore, C. [OECD Nuclear Energy Agency, 92 - Issy les Moulineaux (France)

    2008-07-01

    Issues of public concern during decommissioning and dismantling (D and D) are partly the same and partly different from those of the preceding phases (planning, construction and operation). While in the course of construction and operation the main challenges include meeting expectations of a higher quality of life, accommodating a growing population, mitigating construction nuisances, and assuring the safe operation of the facility, the main concerns in the D and D phase are decreasing employment rate, the eventual reduction of revenues for the municipality, the future use of the affected land and negative social impacts (e.g., out-migration). The decommissioning phase is characterised by heterogeneity of stakeholder interests and values, difficulties of reaching consensus or compromise, and difficulties in connection with the harmonization of energy production, environmental protection and sustainable socio-economic development considerations. Typically, there might also be tensions between local and regional decisions. As in other phases, the building of trust between stakeholder is crucial from the point of view of conflict management, and social lessons learnt from the siting and developments of nuclear facilities are widely applicable in the field of D and D as well. A review is presented of major lessons to be learnt from NEA activities in the field of decommissioning and stakeholder involvement. (author)

  19. Lessons learned from accidents in radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz-Lopez, P [International Atomic Energy Agency, Vienna (Austria). Div. of Nuclear Safety; Novotny, J [University Hospital St. Rafael, Leuven (Belgium); Haywood, J [South Cleveland Hospital (United Kingdom). Cleveland Medical Physics Unit

    1996-08-01

    Radiotherapy is the only application of radiation which intentionally delivers very high doses to humans. A gross deviation from the prescribed dose or dose distribution can have severe, or even fatal consequences. Since the patient is placed directly in the beam or sources are inserted in the body, any mistake made with the beam or the sources leads almost certainly to an accidental exposure. Lessons learned from previous incidents can be used to test the vulnerability of a given facility, provided that these are adequately disseminated. The purpose of this paper is to present a summary of the lessons learned from a relatively large sample of events. The analysis has been presented as a short description followed by an identification of the triggering event and the contributing factors. These have been grouped as follows: errors in commissioning or calibration machines and sources affecting many patients; mistakes affecting individual patients such as irradiating the wrong patient, the wrong, field or site, and mistakes when entering data into or reading from the patient`s chart; error due to unusual treatments or situations; equipment failure and human machine problems, including maintenance. (author). 1 ref.

  20. Lessons learned from women in leadership positions.

    Science.gov (United States)

    Elias, Eileen

    2018-01-01

    Eileen Elias has decades of experience in leadership positions within government and nongovernmental organizations. As the first female Commissioner for Mental Health in the Commonwealth of Massachusetts and the US in the early 1990s, Elias gained experience on navigating gender-based challenges to attain recognized performance outcomes. From lessons learned from women leaders, educate young women entering their careers on attaining leadership positions. Comprehensive research of literature from 2012 through 2017 and interviews with women leaders representing non-Fortune 500 companies including academia, research, non-profit, for-profit, and primary and secondary education. Interviewees included:1.Gail Bassin, Co-Chief Executive Officer and Treasurer, JBS International Inc.2.Jeri Epstein, Executive Director, The Ambit Foundation3.Valerie Fletcher, Executive Director, Institute for Human Centered Design4.Christine James-Brown, President and CEO, Child Welfare League of America5.Daria Mochly-Rosen, PhD, Professor and Fellow, Chemical and Systems Biology, Stanford University School of Medicine6.Eileen O'Keefe, MD, MPH, Clinical Associate Professor and Director, Boston University Health Sciences7.Jeri Shaw, President and Co-Chief Executive Officer, JBS International Inc. A comprehensive understanding of key women leaders' lessons learned and recommendations targeting young women as they assess leadership opportunities in the public or private sectors.

  1. Development of short Indonesian lesson plan to improve teacher performance

    Science.gov (United States)

    Yulianto, B.; Kamidjan; Ahmadi, A.; Asteria, P. V.

    2018-01-01

    The developmental research was motivated by the results of preliminary study through interviews, which revealed almost all of the teachers did not create lesson plan themselves. As a result of this load, the performance of the real learning in the classroom becomes inadequate. Moreover, when lesson plan was not made by teachers themselves, the learning process becomes ineffective. Therefore, this study designed to develop a prototype of the short lesson plan, in particular, Indonesian language teaching, and to investigate its effectiveness. The participants in the study were teachers who were trained through lesson study group to design short model’s lesson plan. Questionnaires and open-ended questions were used, and the quantitative and qualitative data obtained were analyzed accordingly. The analysis of the quantitative data, aided with SPSS, were frequency, percentage, and means, whereas the qualitative data were analyzed descriptively. The results showed that the teachers liked the model, and they were willing to design their own lesson plan. The observation data revealed that the classroom learning process became more interactive, and classroom atmosphere was more engaging and natural because the teachers did not stick to the lesson plan made by other teachers.

  2. "Elements of Astronomy": A Television Course of 30 Lessons

    Science.gov (United States)

    Perez, J. P. D.; Del Pozo, E. P. G.; Rodriguez, R. R. T.; Mendez, A. M. B.; Rodriguez, E. R. F.; Gamez, R. G. D.

    2006-08-01

    It was broadcasted to all Cuba from March to December 2005, one lesson per week, transmitting three times each lesson, this means 90 hours of broadcasting. It was one of the courses of the Program "University for All", that Educative Channel produced. The Thematic: Sky Coordinates and Constellations; Astronomical Instruments; Solar System; Planets and their Moons; Comets, Asteroids and Meteoroids; Sun; Cosmic Environment and Space Weather; Stars; Galaxy and Quasars; Observable Universe; Life, Intelligent Life and Civilizations in the Universe; and History of Astronomy in Cuba. The professor staff was a group of 5 researchers of the Astronomy Department. They did an effort that each lesson had the best information level with a minimum of mathematical expressions. And were used more than 60 slides and various astronomical films fragments per lesson. To make one lesson was analyzed several astronomical films, selected a group of fragments and pre-edited into various blocks with the TV specialists, later a power point presentation was conformed using all available information on-line and bibliography. Then the lesson was recorded by the TV specialist at the Educative Channel and latter reviewed and improved by one AVID edition. The Course groundwork began in April 2003, with the first list of 12 lessons, later in June was increased to18 lessons, and started the work of "Tabloide" making; it is a journal-type book of 32 pages, equivalent to about 120 normal pages including 64 illustrations. At December 2004 the Course was increased to 30 lessons and the "Tabloide" was send to editor, later 200,000 exemplars was published. Many people followed Course and "Tabloide" was shopped in some months.

  3. The application of micro-lesson in optics teaching

    Science.gov (United States)

    Yuan, Suzhen; Mao, Xuefeng; Lu, Yongle; Wang, Yan; Luo, Yuan

    2017-08-01

    In order to improve students' ability on self-study, this paper discusses the application of micro-lesson as a supplementary way in the course of optics teaching. Both geometric optics and wave optics require a lot of demos, fortunately, micro-lesson just meets this requirement. Nowadays, college education focuses on quality education, so the new nurture scheme of most universities shortened the class hours. However, the development of students and the social needs also require students to have a solid foundation. The effective way to solve this contradiction is to improve the efficiency of classroom teaching and provide the repeatable learning form, micro-lesson.

  4. Bruce A restart (execution and lessons-learned)

    International Nuclear Information System (INIS)

    Soini, J.

    2011-01-01

    Lessons learned with the Bruce Units 3 and 4 restart have been incorporated into the current refurbishment of Units 1 and 2. In addition, lessons learned on the lead unit (U2) are aggressively applied on the lagging unit (U1) to maximize efficiency and productivity. There will be a discussion on how this internal OPEX, along with external lessons learned, are used to continuously improve all aspects of the Bruce A Restart project management cycle, from scope selection, through planning and scheduling, to execution.

  5. Spent Fuel Storage Operation - Lessons Learned

    International Nuclear Information System (INIS)

    2013-12-01

    Experience gained in planning, constructing, licensing, operating, managing and modifying spent fuel storage facilities in some Member States now exceeds 50 years. Continual improvement is only achieved through post-project review and ongoing evaluation of operations and processes. This publication is aimed at collating and sharing lessons learned. Hopefully, the information provided will assist Member States that already have a developed storage capability and also those considering development of a spent nuclear fuel storage capability in making informed decisions when managing their spent nuclear fuel. This publication is expected to complement the ongoing Coordinated Research Project on Spent Fuel Performance Assessment and Research (SPAR-III); the scope of which prioritizes facility operational practices in lieu of fuel and structural components behaviour over extended durations. The origins of the current publication stem from a consultants meeting held on 10-12 December 2007 in Vienna, with three participants from the IAEA, Slovenia and USA, where an initial questionnaire on spent fuel storage was formulated (Annex I). The resultant questionnaire was circulated to participants of a technical meeting, Spent Fuel Storage Operations - Lessons Learned. The technical meeting was held in Vienna on 13-16 October 2008, and sixteen participants from ten countries attended. A consultants meeting took place on 18-20 May 2009 in Vienna, with five participants from the IAEA, Slovenia, UK and USA. The participants reviewed the completed questionnaires and produced an initial draft of this publication. A third consultants meeting took place on 9-11 March 2010, which six participants from Canada, Hungary, IAEA, Slovenia and the USA attended. The meeting formulated a second questionnaire (Annex II) as a mechanism for gaining further input for this publication. A final consultants meeting was arranged on 20-22 June 2011 in Vienna. Six participants from Hungary, IAEA, Japan

  6. Towards a lessons learned system for critical software

    International Nuclear Information System (INIS)

    Andrade, J.; Ares, J.; Garcia, R.; Pazos, J.; Rodriguez, S.; Rodriguez-Paton, A.; Silva, A.

    2007-01-01

    Failure can be a major driver for the advance of any engineering discipline and Software Engineering is no exception. But failures are useful only if lessons are learned from them. In this article we aim to make a strong defence of, and set the requirements for, lessons learned systems for safety-critical software. We also present a prototype lessons learned system that includes many of the features discussed here. We emphasize that, apart from individual organizations, lessons learned systems should target industrial sectors and even the Software Engineering community. We would like to encourage the Software Engineering community to use this kind of systems as another tool in the toolbox, which complements or enhances other approaches like, for example, standards and checklists

  7. Bards and Beatles: Connecting Spontaneity to Structure in Lesson Plans.

    Science.gov (United States)

    Cox, Mitch

    1991-01-01

    Describes how one teacher provides minimally structured lessons that encourage senior high school students to carry their learning beyond the classroom. Describes units on business communication, research, British literature, and independent reading. (MG)

  8. Lessons From Managerial Theories for Improving Virtualness in Electronic Business

    NARCIS (Netherlands)

    Wassenaar, Arjen; Govindaraju, Rajesri; Govindaraju, R.; Moreno Bragado, Elisa; Moreno Bragado, Elisa; von Raesfeld Meijer, Ariane M.; Ribbers, Pieter; Swagerman, D.M.; Sieber, Pascal; Griese, Joachim

    1998-01-01

    Electronic business and virtual organisations are important research topics in the IS research community today. At the same time these research topics are very appropriate for interdisciplinary research. The panel aims: - presentation of lessons from managerial theories for improving organisational

  9. Towards a lessons learned system for critical software

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, J. [University of A Coruna. Campus de Elvina, s/n. 15071, A Coruna (Spain)]. E-mail: jag@udc.es; Ares, J. [University of A Coruna. Campus de Elvina, s/n. 15071, A Coruna (Spain)]. E-mail: juanar@udc.es; Garcia, R. [University of A Coruna. Campus de Elvina, s/n. 15071, A Coruna (Spain)]. E-mail: rafael@udc.es; Pazos, J. [Technical University of Madrid. Campus de Montegancedo, s/n. 28660, Boadilla del Monte, Madrid (Spain)]. E-mail: jpazos@fi.upm.es; Rodriguez, S. [University of A Coruna. Campus de Elvina, s/n. 15071, A Coruna (Spain)]. E-mail: santi@udc.es; Rodriguez-Paton, A. [Technical University of Madrid. Campus de Montegancedo, s/n. 28660, Boadilla del Monte, Madrid (Spain)]. E-mail: arpaton@fi.upm.es; Silva, A. [Technical University of Madrid. Campus de Montegancedo, s/n. 28660, Boadilla del Monte, Madrid (Spain)]. E-mail: asilva@fi.upm.es

    2007-07-15

    Failure can be a major driver for the advance of any engineering discipline and Software Engineering is no exception. But failures are useful only if lessons are learned from them. In this article we aim to make a strong defence of, and set the requirements for, lessons learned systems for safety-critical software. We also present a prototype lessons learned system that includes many of the features discussed here. We emphasize that, apart from individual organizations, lessons learned systems should target industrial sectors and even the Software Engineering community. We would like to encourage the Software Engineering community to use this kind of systems as another tool in the toolbox, which complements or enhances other approaches like, for example, standards and checklists.

  10. Water — The common element: Lessons from antiquity and the ...

    African Journals Online (AJOL)

    Water — The common element: Lessons from antiquity and the health of the environment Presidential address delivered at the 37th congress of the Southern African Society of Aquatic Scientists, Swakopmund, Namibia.

  11. Considerations for implementing an organizational lessons learned process.

    Energy Technology Data Exchange (ETDEWEB)

    Fosshage, Erik D

    2013-05-01

    This report examines the lessons learned process by a review of the literature in a variety of disciplines, and is intended as a guidepost for organizations that are considering the implementation of their own closed-loop learning process. Lessons learned definitions are provided within the broader context of knowledge management and the framework of a learning organization. Shortcomings of existing practices are summarized in an attempt to identify common pitfalls that can be avoided by organizations with fledgling experiences of their own. Lessons learned are then examined through a dual construct of both process and mechanism, with emphasis on integrating into organizational processes and promoting lesson reuse through data attributes that contribute toward changed behaviors. The report concludes with recommended steps for follow-on efforts.

  12. Lessons and challenges from software quality assessment: The ...

    African Journals Online (AJOL)

    Lessons and challenges from software quality assessment: The case of space systems software. ... esoteric software technologies and paradigms such as object oriented development, etc. ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  13. A Reasoned Action Approach to Participation in Lesson Study

    NARCIS (Netherlands)

    de Vries, Siebrichje; Roorda, Gerrit

    2016-01-01

    This exploratory study investigates teachers’ attitude toward Lesson Study (LS), a professional development approach which is relatively unknown in the Netherlands. The paper reports a qualitative study based on the Reasoned Action Approach, which explains how teachers’ beliefs influence their

  14. Antiretroviral therapy in a community clinic - early lessons from a ...

    African Journals Online (AJOL)

    Antiretroviral therapy in a community clinic - early lessons from a pilot project. ... The HIV Research Unit, University of Cape Town, supplied training and ... Attention must be given to the diagnosis of tuberculosis during screening and early ART ...

  15. Applying lessons from the ecohealth approach to make food ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Applying lessons from the ecohealth approach to make food systems healthier ... the biennial Ecohealth Congress of the International Association for Ecology and ... intersectoral policies that address the notable increase in obesity, diabetes, ...

  16. A Jigsaw Lesson for Operations of Complex Numbers.

    Science.gov (United States)

    Lucas, Carol A.

    2000-01-01

    Explains the cooperative learning technique of jigsaw. Details the use of a jigsaw lesson for explaining complex numbers to intermediate algebra students. Includes copies of the handouts given to the expert groups. (Author/ASK)

  17. How Asian Teachers Polish Each Lesson to Perfection.

    Science.gov (United States)

    Stigler, James W.; Stevenson, Harold W.

    1991-01-01

    Compares elementary mathematics instruction in Taiwan, Japan, Chicago, and Minneapolis. Finds that American teachers are overworked and devote less time to conducting lessons than Asian teachers, who employ proven inductive methods within the framework of standardized curricula. (DM)

  18. Ebola Viral Hemorrhagic Disease Outbreak in West Africa- Lessons ...

    African Journals Online (AJOL)

    ... to contain the Ebola epidemic. Key words: Ebola, viral hemorrhagic fever, West Africa, lessons, Uganda .... the corresponding surveillance systems for detecting priority diseases. ... A major outbreak of Yellow Fe- ver was reported in five ...

  19. Closing the gap between people and programs: lessons from ...

    African Journals Online (AJOL)

    Closing the gap between people and programs: lessons from implementation of social accountability for family planning and reproductive health in Uganda. Vicky Boydell, Stella Neema, Kelsey Wright, Karen Hardee ...

  20. Winning the Peace: Building a Strategic Level Lessons Learned Program

    National Research Council Canada - National Science Library

    French, Daniel L

    2007-01-01

    The U.S. military has developed a robust, comprehensive system to capture, analyze, and disseminate tactical-level and operational-level lessons learned from training events and ongoing conflict operations...

  1. ICT AND TEACHERS' PERFORMANCE IN TERMS OF LESSON ...

    African Journals Online (AJOL)

    PROF. BARTH EKWEME

    Delivery Questionnaire (ICTTPLIDO) Developed by the researcher. The reliability estimate of ... teachers' performance in lesson preparation and delivery through the use of Information and ... information to accomplish the task, and evaluating ...

  2. Guest Editorial: Health financing lessons from Thailand for South ...

    African Journals Online (AJOL)

    Guest Editorial: Health financing lessons from Thailand for South Africa on the path towards universal health coverage. Mark Blecher, Anban Pillay, Walaiporn Patcharanarumol, Warisa Panichkriangkrai, Viroj Tangcharoensathien, Yot Teerawattananon, Supasit Pannarunothai, Jonatan Davén ...

  3. Lessons on the Right to Health Litigation and MDGS for ...

    African Journals Online (AJOL)

    mobilization are important lessons for implementing health related SDGs in South ... 6 on availability and sustainable management of water and sanitation, Goal 12 on ..... Equally, that the decision will contribute positively in benchmarking the.

  4. Regional climate science: lessons and opportunities

    Science.gov (United States)

    Mote, P. W.; Miles, E. L.; Whitely Binder, L.

    2008-12-01

    Since its founding in 1995, the Climate Impacts Group (CIG) at the University of Washington (UW) has achieved remarkable success at translating global- and regional-scale science into forms and products that are useful to, and used by, decision-makers. From GCM scenarios to research on the connection between global climate patterns and locally important factors like floods and wildfires, CIG's strong physical science foundation is matched by a vigorous and successful outreach program. As a result, CIG and its partner the Office of Washington State Climatologist at UW have made substantial progress at bridging the gap between climate science and decision-making, and are deeply involved in advising all levels of government and many business interests on adapting to climate variability and change. This talk will showcase some of the specific activities and tools, describe lessons learned, and illustrate how such efforts fit into a "National Climate Service."

  5. The lessons of SARS in Hong Kong.

    Science.gov (United States)

    Lai, Thomas Sik To; Yu, Wai Cho

    2010-02-01

    Severe acute respiratory syndrome (SARS) is a novel coronavirus infection which broke out in Hong Kong in March 2003. Princess Margaret Hospital was designated to manage this new, mysterious and serious disease. Healthcare workers had to work under extremely stressful and often risky conditions to care for patients. Despite manpower and equipment reinforcements, staff infection occurred as a result of bodily exhaustion, working in an unfamiliar environment and lapses in infection control. Patients suffered even more, not only due to physical discomfort, but also because of the fear of isolation and death away from family and friends. Health authorities learnt their lessons in the outbreak and formulated emergency plans for future infectious disease epidemics. The healthcare infrastructure has been examined and upgraded with regard to intensive care capacity, infection control measures, professional training, manpower deployment, staff facilities, and stockpiling of drugs and personal protective equipment.

  6. Microplastics: addressing ecological risk through lessons learned.

    Science.gov (United States)

    Syberg, Kristian; Khan, Farhan R; Selck, Henriette; Palmqvist, Annemette; Banta, Gary T; Daley, Jennifer; Sano, Larissa; Duhaime, Melissa B

    2015-05-01

    Plastic litter is an environmental problem of great concern. Despite the magnitude of the plastic pollution in our water bodies, only limited scientific understanding is available about the risk to the environment, particularly for microplastics. The apparent magnitude of the problem calls for quickly developing sound scientific guidance on the ecological risks of microplastics. The authors suggest that future research into microplastics risks should be guided by lessons learned from the more advanced and better understood areas of (eco) toxicology of engineered nanoparticles and mixture toxicity. Relevant examples of advances in these two fields are provided to help accelerate the scientific learning curve within the relatively unexplored area of microplastics risk assessment. Finally, the authors advocate an expansion of the "vector effect" hypothesis with regard to microplastics risk to help focus research of microplastics environmental risk at different levels of biological and environmental organization. © 2015 SETAC.

  7. Important lessons to be learnt from 'Daimler'

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2014-01-01

    ” (hinreichende Wahrscheinlichkeit). Disclosure should take place when there is a “realistic prospect” (tatsächlich erwartet werden kann) that the future event will occur. Intermediate steps (Zwischenschritte) can in themselves be stock relevant. Third, under German law, as well as under US law, it is natural...... to be able to sue the quoted company itself on grounds of misleading or delayed stock announcements. Other countries, including Denmark, are gradually coming to a similar state of law, however without statutory law to guide investors. The lesson for the EU should be that common rules are needed in this field...... implemented the market abuse directive, it must have trusted the German version of it (like countries often do). However, this version demanded too high a probability that a stock relevant event would occur, and German legislation was based on the German version of the directive. The Court compared...

  8. Digital control for nuclear reactors - lessons learned

    International Nuclear Information System (INIS)

    Bernard, J.A.; Aviles, B.N.; Lanning, D.D.

    1992-01-01

    Lessons learned during the course of the now decade-old MIT program on the digital control of nuclear reactors are enumerated. Relative to controller structure, these include the importance of a separate safety system, the need for signal validation, the role of supervisory algorithms, the significance of command validation, and the relevance of automated reasoning. Relative to controller implementation, these include the value of nodal methods to the creation of real-time reactor physics and thermal hydraulic models, the advantages to be gained from the use of real-time system models, and the importance of a multi-tiered structure to the simultaneous achievement of supervisory, global, and local control. Block diagrams are presented of proposed controllers and selected experimental and simulation-study results are shown. In addition, a history is given of the MIT program on reactor digital control

  9. Lessons learnt from WLCG service deployment

    International Nuclear Information System (INIS)

    Shiers, J D

    2008-01-01

    This paper summarises the main lessons learnt from deploying WLCG production services, with a focus on Reliability, Scalability, Accountability, which lead to both manageability and usability. Each topic is analysed in turn. Techniques for zero-user-visible downtime for the main service interventions are described, together with pathological cases that need special treatment. The requirements in terms of scalability are analysed, calling for as much robustness and automation in the service as possible. The different aspects of accountability - which covers measuring/tracking/logging/monitoring what is going on - and has gone on - is examined, with the goal of attaining a manageable service. Finally, a simple analogy is drawn with the Web in terms of usability - what do we need to achieve to cross the chasm from small-scale adoption to ubiquity?

  10. Lessons learned using Snodgrass hypospadias repair.

    LENUS (Irish Health Repository)

    O'Connor, K M

    2012-02-03

    BACKGROUND: This is a review of our experience with the Snodgrass technique for distal hypospadias repair and we point to lessons learned in improving results. METHODS: We reviewed all patients who underwent Snodgrass hypospadias repair for distal hypospadias over a four-year period by a single surgeon. Chart review followed by parental telephone interview was used to determine voiding function, cosmesis and complication rate. RESULTS: Thirty children and three adults were identified. Age at surgery ranged from seven months to 39 years. The urinary stream was straight in 94%, and 97% reported a good or satisfactory final cosmetic outcome. One patient (3.3%) developed a urethral fistula and 21% developed meatal stenosis which required general anaesthetic. CONCLUSION: The Snodgrass urethroplasty provides satisfactory cosmetic and functional results. High rates of meatal stenosis initially encountered have improved with modifications to technique which include modified meatoplasty and routine meatal dilatation by the parents.

  11. Lessons learned in wake of WPPSS

    International Nuclear Information System (INIS)

    Koenen, A.V.; Gillespie, J.W.

    1984-01-01

    Several fundamentals of public power financial management have become more critical in the wake of the Washington Public Power Supply System (WPPSS) default: the human and financial costs of trying to resolve problems of this complexity after they occur will require an almost unimaginable amount of time and money that could be productively employed elsewhere; the economic feasibility of the project is paramount, and is far more important than its legal security or its attractiveness to utility managers; the ratepayers' ability and willingness to pay is the key security in public power financing; management performance, not promises, will be the measure of the post WPPSS marketplace; financial flexibility is crucial. Using these lessons, the author outlines a five-step program of strategic planning for planning and managing long-term projects

  12. Lessons on collisionless reconnection from quantum fluids

    Directory of Open Access Journals (Sweden)

    Yasuhito eNarita

    2014-12-01

    Full Text Available Magnetic reconnection in space plasmas remains a challenge in physics in that the phenomenon is associated with the breakdown of frozen-in magnetic field in a collisionless medium. Such a topology change can also be found in superfluidity, known as the quantum vortex reconnection. We give a plasma physicists' view of superfluidity to obtain insights on essential processes in collisionless reconnection, including discussion of the kinetic and fluid pictures, wave dynamics, and time reversal asymmetry. The most important lesson from the quantum fluid is the scenario that reconnection is controlled by the physics of topological defects on the microscopic scale, and by the physics of turbulence on the macroscopic scale. Quantum vortex reconnection is accompanied by wave emission in the form of Kelvin waves and sound waves, which imprints the time reversal asymmetry.

  13. Lessons learned during Type A Packaging testing

    International Nuclear Information System (INIS)

    O'Brien, J.H.; Kelly, D.L.

    1995-11-01

    For the past 6 years, the US Department of Energy (DOE) Office of Facility Safety Analysis (EH-32) has contracted Westinghouse Hanford Company (WHC) to conduct compliance testing on DOE Type A packagings. The packagings are tested for compliance with the U.S. Department of Transportation (DOT) Specification 7A, general packaging, Type A requirements. The DOE has shared the Type A packaging information throughout the nuclear materials transportation community. During testing, there have been recurring areas of packaging design that resulted in testing delays and/or initial failure. The lessons learned during the testing are considered a valuable resource. DOE requested that WHC share this resource. By sharing what is and can be encountered during packaging testing, individuals will hopefully avoid past mistakes

  14. Vacuum performances and lessons for 2012

    International Nuclear Information System (INIS)

    Baglin, V.; Bregliozzi, G.; Jimenez, J.M.; Lanza, G.

    2012-01-01

    During the LHC run 2011, a tremendous progress has been made towards the machine operation with design parameters. In the same time, the run confirmed the sensitivity of the beam vacuum system to the machine parameters. As expected, a successful scrubbing period allowed mitigating the effects of the electron cloud giving room to an entire filling of the ring with 50 ns beams. In parallel issues such as the impact of the beam screen regulation, pressures spikes and local outgassing were observed during the year. On-line mitigations and immediate compensatory measures implemented during the winter technical stop are reviewed together with their efficiencies. All unexpected pressure behaviours observed during 2011 are understood. The expected limitations while waiting for LS1 consolidation or when running with 25 ns beams are addressed. Lessons for 2012 are discussed. (authors)

  15. Sellafield Decommissioning Programme - Update and Lessons Learned

    International Nuclear Information System (INIS)

    Lutwyche, P. R.; Challinor, S. F.

    2003-01-01

    The Sellafield site in North West England has over 240 active facilities covering the full nuclear cycle from fuel manufacture through generation, reprocessing and waste treatment. The Sellafield decommissioning programme was formally initiated in the mid 1980s though several plants had been decommissioned prior to this primarily to create space for other plants. Since the initiation of the programme 7 plants have been completely decommissioned, significant progress has been made in a further 16 and a total of 56 major project phases have been completed. This programme update will explain the decommissioning arrangements and strategies and illustrate the progress made on a number of the plants including the Windscale Pile Chimneys, the first reprocessing plan and plutonium plants. These present a range of different challenges and requiring approaches from fully hands on to fully remote. Some of the key lessons learned will be highlighted

  16. Lessons taught by the Chernobyl accident

    International Nuclear Information System (INIS)

    Anon.

    2002-01-01

    On nuclear development, it is natural that safety is the most important condition. However, when occurring an accident in spite of earnest efforts on safety pursuit, it is essential for a technical developer to absorb some lessons from its contents as much as possible and show an attitude to use thereafter. The Chernobyl accident brought extraordinarily large damage in the history of nuclear technology development. Therefore, the edition group of the Japan Society of Atomic Energy introduced opinions of three groups of the Society (that is, groups on reactor physics, nuclear power generation, and human-machine system research) with some description on cause analysis of the accident and its result and effect. And, here was also shown four basic difference on design between RMBK type reactor in Chernobyl and LWR type reactor supplied in Japan. (G.K.)

  17. Lessons from the history of medicine.

    Science.gov (United States)

    Waller, John

    2008-01-01

    What is the point of teaching the history of medicine? Many historians and clinicians find it regrettable that some medical students today will graduate knowing almost nothing of such "greats" of the past as Hippocrates, Galen, Vesalius, Harvey, Lister, and Pasteur. But does this really matter? After all, traditional history of medicine curricula tended to distort medicine's past, omitting the countless errors, wrong turns, fads, blunders, and abuses, in order to tell the sanitized stories of a few scientific superheroes. Modern scholarship has seriously challenged most of these heroic dramas; few of our heroes were as farsighted, noble, or obviously correct as once thought. Joseph Lister, for example, turns out to have had filthy wards, whereas William Harvey was devoted to the Aristotelianism he was long said to have overthrown [1]. But as the history of medicine has become less romanticized, it has also become much more relevant, for it promises to impart useful lessons in the vital importance of scientific scepticism.

  18. Lessons learned from the 1994 Northridge Earthquake

    International Nuclear Information System (INIS)

    Eli, M.W.; Sommer, S.C.

    1995-01-01

    Southern California has a history of major earthquakes and also has one of the largest metropolitan areas in the United States. The 1994 Northridge Earthquake challenged the industrial facilities and lifetime infrastructure in the northern Los Angeles (LA) area. Lawrence Livermore National Laboratory (LLNL) sent a team of engineers to conduct an earthquake damage investigation in the Northridge area, on a project funded jointly by the United States Nuclear Regulatory Commission (USNRC) and the United States Department of Energy (USDOE). Many of the structures, systems, and components (SSCs) and lifelines that suffered damage are similar to those found in nuclear power plants and in USDOE facilities. Lessons learned from these experiences can have some applicability at commercial nuclear power plants

  19. XML technology planning database : lessons learned

    Science.gov (United States)

    Some, Raphael R.; Neff, Jon M.

    2005-01-01

    A hierarchical Extensible Markup Language(XML) database called XCALIBR (XML Analysis LIBRary) has been developed by Millennium Program to assist in technology investment (ROI) analysis and technology Language Capability the New return on portfolio optimization. The database contains mission requirements and technology capabilities, which are related by use of an XML dictionary. The XML dictionary codifies a standardized taxonomy for space missions, systems, subsystems and technologies. In addition to being used for ROI analysis, the database is being examined for use in project planning, tracking and documentation. During the past year, the database has moved from development into alpha testing. This paper describes the lessons learned during construction and testing of the prototype database and the motivation for moving from an XML taxonomy to a standard XML-based ontology.

  20. LESSONS LEARNED IN TESTING OF SAFEGUARDS EQUIPMENT

    International Nuclear Information System (INIS)

    Pepper, S.; Farnitano, M.; Carelli, J.; Hazeltine, J.; Bailey, D.

    2001-01-01

    The International Atomic Energy Agency's (IAEA) Department of Safeguards uses complex instrumentation for the application of safeguards at nuclear facilities around the world. Often, this equipment is developed through cooperation with member state support programs because the Agency's requirements are unique and are not met by commercially available equipment. Before approving an instrument or system for routine inspection use, the IAEA subjects it to a series of tests designed to evaluate its reliability. In 2000, the IAEA began to observe operational failures in digital surveillance systems. In response to the observed failures, the IAEA worked with the equipment designer and manufacturer to determine the cause of failure. An action plan was developed to correct the performance issues and further test the systems to make sure that additional operational issues would not surface later. This paper addresses the steps taken to address operation issues related to digital image surveillance systems and the lessons learned during this process

  1. Keynote on lessons from major radiation accidents

    International Nuclear Information System (INIS)

    Ortiz, P.; Oresegun, M.; Wheatley, J.

    2000-01-01

    Generic lessons have been learned from a relatively large number of accidents in the most relevant practices (a set of analysis have been made on about 90 radiotherapy events, 43 industrial radiography and nine from industrial irradiations); more specific lessons have been drawn from in-depth investigations of individual accidents. The body of knowledge is grouped as follows: a) radiotherapy is very unique in that humans (patients) are purposely given very high radiation doses (20-75 Gy) by placing them in the radiation beam or by placing radioactive sources in contact with tissues. Intended deterministic effects are the essence of the normal radiotherapy practice and relatively small deviation from the intended doses, i.e,, slightly higher or lower than intended may cause increased rate of severe complication or reduce probability of cure. Consequences of major accidents have been devastating, affecting tens, even hundreds of patients and causing death (directly or indirectly) to a large number of them; b) accidents involving industrial radiography are the most frequent cause of overexposure to workers (radiographers); c) accidents with industrial irradiators have lower probability of occurrence, however, they are deemed to be fatal, especially when whole body exposure to panoramic gamma irradiators occur; partial body irradiation from industrial or research accelerator beams has led to amputation of hands and legs; d) when control of sources was relinquished ('orphan' sources) this has resulted in severe injuries, in some cases death and widespread contamination of the environment. A tool for further dissemination of lessons will be an international reporting system of unusual radiation events (RADEV), being introduced world-wide. Accidents were rarely due to a single human error or isolated equipment failure. In most cases there was a combination of elements such as: a) unawareness of the potential for an accident, b) poor education, which usually did not

  2. Software Engineering Team Project - lessons learned

    Directory of Open Access Journals (Sweden)

    Bogumiła Hnatkowska

    2013-06-01

    Full Text Available In the 2010/11 academic year the Institute of Informatics at Wroclaw University of Technology issued ’Software Engineering Team Project’ as a course being a part of the final exam to earn bachelor’s degree. The main assumption about the course was that it should simulate the real environment (a virtual IT company for its participants. The course was aimed to introduce issues regarding programming in the medium scale, project planning and management. It was a real challenge as the course was offered for more than 140 students. The number of staff members involved in its preparation and performance was more than 15. The paper presents the lessons learned from the first course edition as well as more detailed qualitative and quantitative course assessment.

  3. 毛泽东邓小平理论研究

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Certain Ideas of Mao Zedong on the Construction of Socialist Culture: Mao Zedong's Cultural Thought is an important part of Mao Zedong Thought, and Mao Zedong's thinking on the building socialist culture is an important aspect of Mao Zedong's Cultural Thought. In this paper, the author made a carding from seven aspects of Mao Zedong about socialist culture construction thoughts. Generally speaking, Mao Zedong about socialist culture construction thoughts constitutes a very complete system. Admittedly, the Party leadership once experienced major twists and turns in the leading process of cultural work, and even made a serious mistake. There is no doubt that the problems occurred in the cultural work, we must look at them squarely and seriously learn a lesson from them. However, we cannot accordingly deny many correct thoughts of Mao Zedong on socialist culture construction fundamentally.(SHA Jian-sun)

  4. SMART-1: Development and lessons learnt

    Science.gov (United States)

    Rathsman, Peter; Kugelberg, Joakim; Bodin, Per; Racca, Giuseppe D.; Foing, Bernard; Stagnaro, Luca

    2005-07-01

    SMART-1 is the first of the small missions for advanced research and technology as part of ESA's science programme “Cosmic vision”. It was successfully launched on September 27, 2003 and is presently traveling towards its destination, the Moon. The main objective of the mission, to demonstrate solar electric primary propulsion for future Cornerstones (such as Bepi-Colombo), has already been achieved. At the time of writing the electric propulsion system has been working already for more than 3400 h and has provided a Delta-V to the spacecraft of more than 2500 m/s. The other technology objectives are also being fulfilled by the verification of the proper functioning of such on-board experiments like the X-Ka band transponder, the X-ray spectrometer, the near IR spectrometer, the laser link, etc. The scientific objectives are related to lunar science and will be fulfilled once the spacecraft enters its operational lunar orbit, currently expected for January 2005. SMART-1 lunar science investigations will include studies of the chemical composition of the Moon, of geophysical processes, environment and high-resolution studies in preparation for future steps of lunar exploration. SMART-1 has been an innovative mission in many aspects and we are now drawing some preliminary conclusions about the lessons to be learnt. The paper describes the spacecraft and the technology elements with particular emphasis to the technology nature of the mission. The on-board avionics employs many novel designs for spacecraft, including a serial CAN bus for data communication, autonomous star trackers and extensive use of auto-code generation for implementing the attitude control system and the failure, detection, isolation and recovery (FDIR). Finally, the orbital operation phase currently ongoing, including the routine electric propulsion operations and the instrument commissioning, is providing a wealth of data and lesson-learnt useful for future autonomous planetary missions.

  5. NAPAP: A lesson in science, policy

    International Nuclear Information System (INIS)

    Russell, M.

    1993-01-01

    Perplexing environmental questions, such as acid rain and global warming, cry out for policy solutions based upon solid scientific evidence. Scientists and politicians agree on this but have trouble finding an effective way to do it. Milton Russell of the University of Tennessee and Oak Ridge National Laboratory describes a major, but only partially successful, effort that he believes contains valuable lessons for scientists and policy makers in the future. It is the National Acid Precipitation Assessment Program (NAPAP), launched in 1980 to generate the latest scientific evidence to guide national debate on clean-air legislation. The program open-quotes created an unprecedented body of scientific research on an environmental issue of the first order,close quotes Russell says. Yet, he admits, its influence was virtually nil on the legislation that ultimately emerged on the subject. Russell blames this lack of influence on NAPAP's failure to provide adequate assessment of its research findings, its failure to communicate the results on a timely and effective basis, and on open-quotes political forces that sought legislation rather than a full explication of issues.close quotes Out of the experience, Russell finds lessons for the future: open-quotes First, if the scientific finding are to have an impact on policy, assessment must become a priority as important as scientific research. Second, for projects designed to help decision makers, scientific research must be considered a resource, not an end product. Third, timely, lucid communication must be an essential element of the project, not a marginal activity.close quotes NAPAP, Russell concludes, open-quotes proved a long-term scientific success and a short-term policy disappointment.close quotes Then he warns, open-quotes Future science programs ignore the NAPAP experience at their own risk.close quotes

  6. Leading in crisis: lessons for safety leaders.

    Science.gov (United States)

    George, William W; Denham, Charles R; Burgess, L Hayley; Angood, Peter B; Keohane, Carol

    2010-03-01

    The National Quality Forum (NQF) Safe Practices are a group of 34 evidence-based Safe Practices that should be universally used to reduce the risk of harm to patients. Four of these practices specifically address leadership. A recently published book, 7 Lessons for Leading in Crisis, offers practical advice on how to lead in crisis. An analysis of how concepts from the 7 lessons could be applied to the Safe Practices was presented nationally by webinar to assess the audience's reaction to the information. The objective of this article was to present the information and the audience's reaction to it. Recommendations for direct actions that health care leaders can take to accelerate adoption of NQF Safe Practices were presented to health care leaders, followed by an immediate direct survey that used Reichheld's "Net Promoter Score" to assess whether the concepts presented were considered applicable and valuable to the audience. In a separate presentation, the challenges and crises facing nursing leaders were addressed by nursing leaders. Six hundred seventy-four hospitals, with an average of 4.5 participants per hospital, participated in the webinar. A total of 272 safety leaders responded to a survey immediately after the webinar. A Net Promoter Score assessment revealed that 58% of those surveyed rated the value of the information at 10, and 91% scored the value of the webinar to be between 8 and 10, where 10 is considered a strong recommendation that those voting would recommend this program to others. The overwhelmingly high score indicated that the principles presented were important and valuable to this national audience of health care leadership. The 2010 environment of uncertainty and shrinking financial resources poses significant risk to patients and new challenges for leaders at all levels. A values-grounded focus on personal accountability for leading in crisis situations strongly resonates with those interested in or leading patient safety initiatives.

  7. Lessons learned -- NREL Village Power Program

    Energy Technology Data Exchange (ETDEWEB)

    Flowers, L.

    1998-07-01

    In 1993, a workshop was convened at the National Renewable Energy Laboratory (NREL) to discuss the issues of applying renewable energy in a sustainable manner to international rural development. One of the summary recommendations was that NREL could assist in the renewable energy for rural electrification effort by developing and supplying six related activities: resource assessment, comparative analysis and modeling, performance monitoring and analysis, pilot project development, internet-based project data, communications, and training. In response to this recommendation, NREL launched its Village Power Program consisting of these activities that cut across NREL technologies and disciplines. Currently NREL is active in 20 countries, with pilot projects in 12 of those countries. At this time the technologies include photovoltaics, wind, biomass, and hybrids. The rural applications include home lighting and communications, water pumping, schools and health posts, battery charging stations, ecotourism, and village systems. These pilot projects are central to the renewable energy village power development through the demonstration of three aspects critical to replication and implementation of the projects on a significant scale. The three aspects are technical functionality, economic competitiveness, and institutional sustainability. It is important to note that the pilot projects from which NREL's experience has been gained were funded and, in many cases, developed by other organizations and agencies. NREL's role has been one of technical assistance or project management or both. The purpose of this paper is to describe the lessons NREL staff has gleaned from their participation in the various pilot projects. The author hopes that these lessons will help the Renewable Energy-Based Rural Electrification (RERE) community in implementing sustainable projects that lead to replication.

  8. Simulating classroom lessons : an agent-based attempt

    OpenAIRE

    Ingram, Fred; Brooks, Roger John

    2018-01-01

    This is an interim report on a project to construct an agent-based simulation that reproduces some of the interactions between students and their teacher in classroom lessons. In a pilot study, the activities of 67 students and 7 teachers during 40 lessons were recorded using a data collection instrument that currently captures 17 student states and 15 teacher states. These data enabled various conceptual models to be explored, providing empirical values and distributions for the model parame...

  9. Establishing a mathematical Lesson Study culture in Danish teacher education

    DEFF Research Database (Denmark)

    Skott, Charlotte Krog; Østergaard, Camilla Hellsten

    Bridging theory and practice is a general challenge in mathematics teacher education. Research shows that Lesson Study (LS) is an effective way for prospective mathematics teachers to build relations between course work and field experiences......Bridging theory and practice is a general challenge in mathematics teacher education. Research shows that Lesson Study (LS) is an effective way for prospective mathematics teachers to build relations between course work and field experiences...

  10. When do Armed Revolts Succeed: Lessons from Lanchester Theory

    Science.gov (United States)

    2011-10-01

    When do Armed Revolts Succeed: Lessons from Lanchester Theory Michael P. Atkinson 1, Alexander Gutfraind 2, Moshe Kress 1 Abstract Major revolts have...classic Lanchester theory of combat. The model accounts for the split in the population between those loyal to the regime and those favoring the...Lessons from Lanchester Theory 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f

  11. Implementing a lessons learned process at Sandia National Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Fosshage, Erik D.; Drewien, Celeste A.; Eras, Kenneth; Hartwig, Ronald Craig; Post, Debra S.; Stoecker, Nora Kathleen

    2016-01-01

    The Lessons Learned Process Improvement Team was tasked to gain an understanding of the existing lessons learned environment within the major programs at Sandia National Laboratories, identify opportunities for improvement in that environment as compared to desired attributes, propose alternative implementations to address existing inefficiencies, perform qualitative evaluations of alternative implementations, and recommend one or more near-term activities for prototyping and/or implementation. This report documents the work and findings of the team.

  12. Constellation Program: Lessons Learned. Volume 1; Executive Summary

    Science.gov (United States)

    Rhatigan, Jennifer L. (Editor)

    2011-01-01

    This document (Volume I) provides an executive summary of the lessons learned from the Constellation Program. A companion Volume II provides more detailed analyses for those seeking further insight and information. In this volume, Section 1.0 introduces the approach in preparing and organizing the content to enable rapid assimilation of the lessons. Section 2.0 describes the contextual framework in which the Constellation Program was formulated and functioned that is necessary to understand most of the lessons. Context of a former program may seem irrelevant in the heady days of new program formulation. However, readers should take some time to understand the context. Many of the lessons would be different in a different context, so the reader should reflect on the similarities and differences in his or her current circumstances. Section 3.0 summarizes key findings developed from the significant lessons learned at the program level that appear in Section 4.0. Readers can use the key findings in Section 3.0 to peruse for particular topics, and will find more supporting detail and analyses in Section 4.0 in a topical format. Appendix A contains a white paper describing the Constellation Program formulation that may be of use to readers wanting more context or background information. The reader will no doubt recognize some very similar themes from previous lessons learned, blue-ribbon committee reviews, National Academy reviews, and advisory panel reviews for this and other large-scale human spaceflight programs; including Apollo, Space Shuttle, Shuttle/Mir, and the ISS. This could represent an inability to learn lessons from previous generations; however, it is more likely that similar challenges persist in the Agency structure and approach to program formulation, budget advocacy, and management. Perhaps the greatest value of these Constellation lessons learned can be found in viewing them in context with these previous efforts to guide and advise the Agency and its

  13. Benefits of Lessons Expected by Parents : Results of a Survey on Parents Enrolling Their Children in Piano Lessons

    OpenAIRE

    末永,雅子

    2013-01-01

    With the declining birth rate, parents are becoming increasingly interested in childhood education. While the objective of cram schools and English lessons, which are targeted at advancement to higher education, is enhancement of academic ability, the expected benefits of lessons in activities such as piano and sports are not the acquisition of special knowledge or skills, but rather the development of physical fitness, concentration, and other abilities that are useful in dail...

  14. Lesson study in prospective mathematics teacher education: didactic and paradidactic technology in the post-lesson reflection

    DEFF Research Database (Denmark)

    Rasmussen, Klaus

    2016-01-01

    This paper presents a detailed analysis of the post-lesson reflection, carried out in the context of eight cases of lesson study conducted by teams of Danish, lower secondaryprospective teachers and their supervisors. The participants, representing different institutions, were all new to the less...... and concern to the whole profession of mathematics teachers and the analysis adds to our insight into the potential of lesson study in prospective education as a meeting place where pertinent actors contribute to the expansion and dissemination of shared professional knowledge......This paper presents a detailed analysis of the post-lesson reflection, carried out in the context of eight cases of lesson study conducted by teams of Danish, lower secondaryprospective teachers and their supervisors. The participants, representing different institutions, were all new to the lesson...... study format. Nevertheless, it is demonstrated how their interaction shape the development of discourse about mathematical learning. The anthropological theory of the didactic is employed as the theoretical approach to analyse the mathematical and primarily didactical praxeologies developed...

  15. Connecting polar research to NGSS STEM classroom lessons

    Science.gov (United States)

    Brinker, R.; Kast, D.

    2016-12-01

    Next Generation Science Standards (NGSS) are designed to bring consistent, rigorous science teaching across the United States. Topics are categorized as Performance Expectations (PE), Disciplinary Core Ideas (DCI), Cross-Cutting Concepts (CCC), and Science and Engineering Practices (SEP). NGSS includes a focus on environmental science and climate change across grade levels. Earth and planetary sciences are required at the high school level. Integrating polar science lessons into NGSS classrooms brings relevant, rigorous climate change curriculum across grade levels. Polar science provides opportunities for students to use current data during lessons, conduct their own field work, and collaborate with scientists. Polar science provides a framework of learning that is novel to most students. Inquiry and engagement are high with polar science lessons. Phenomenon related to polar science provide an excellent tool for science teachers to use to engage students in a lesson, stimulate inquiry, and promote critical thinking. When taught effectively, students see the connections between their community, polar regions and climate change, regardless of where on the planet students live. This presentation describes examples of how to effectively implement NGSS lessons by incorporating polar science lessons and field research. Examples of introductory phenomenon and aligned PEs, CCCs, DCIs, and SEPs are given. Suggested student activities, assessments, examples of student work, student research, labs, and PolarTREC fieldwork, use of current science data, and connections to scientists in the field are provided. The goals of the presentation are to give teachers a blueprint to follow when implementing NGSS lessons, and give scientists an understanding of the basics of NGSS so they may be better able to relate their work to U.S. science education and be more effective communicators of their science findings.

  16. PENGEMBANGAN MODEL PEMBINAAN KOMPETENSI CALON GURU MATEMATIKA MELALUI LESSON STUDY

    Directory of Open Access Journals (Sweden)

    Rahmad Bustanul Anwar

    2014-06-01

    Full Text Available Education has a very important role in improving the quality of human resources. Therefore, education is expected to be one of the ways to prepare generations of qualified human resources and has the ability to deal with the progress of time and technology development . In order to enhance the quality of student mastery of competencies in the development of prospective teachers in this study will be applied to the activities in the process of lesson study in lecture . Lesson study is a model of coaching to people who work as both teacher educators and lecturers through collaborative learning and assessment in building sustainable learning communities. The purpose of this research is to improve the competence of prospective mathematics teachers through lesson study . More specifically , this study aims to describe the efforts made to improve the pedagogical, professional competence , social competence and personal competence prospective mathematics teachers through lesson study . Subjects in this study were students who took the micro teaching courses totaling 15 students , divided into 3 group . This type of research is a qualitative descriptive study is to develop the competence of prospective mathematics teachers through lesson study . Lesson study conducted collaborated with Action Research activities ( Action Reseach. The results of this research activity is the implementation of lesson study to greater competence to prospective teachers teaching mathematics through the micro subjects namely: pedagogical competence categories were 80 % and 20 % lower, professional competence categories were 46.7 % and 53.3 % lower, personal competence 100 % category being and social competence categories were 86.7 % and 13.3 % lower .

  17. Serbian SNF Repatriation Operation. Issues, Solving, Lesson

    Energy Technology Data Exchange (ETDEWEB)

    Smirnov, A. [Research and Development Company ' Sosny' , Moscow (Russian Federation)

    2011-07-01

    For now the removal of SNF from RA reactor site (PC NFS, Serbia) is the most time-consuming and technically complicated operation under RRRFR Program. The most efficient techniques and lessons learned from other projects of the RRRFR Program as well as new unique technical decisions were used. Two big challenges were resolved during implementation of Serbian Project: (1) preparation of damaged fuel located in the packages unsuitable for transport, taking into account insufficient infrastructure of RA reactor site and (2) removal of large amount of fuel in one multimodal shipment through several transit countries. The main attention was paid to safety justification of all activities. All approvals were obtained in Russia, Serbia and transit countries. Special canisters were designed for transportation of specific RA reactor fuel (of small dimensions, unidentifiable, damaged due to corrosion). The canister design was selected to be untight - it was the most expedient decision for that case from safety perspective. The technology and a set of equipment were designed for remote removal of the fuel from the existing package (aluminum barrels and reactor channels) and placing of the fuel into the new canisters. After fabrication and assembling of the equipment theoretical and practical training of the personnel was performed. Fuel repackaging took about 5 months. SNF was transported in TUK-19 and SKODA VPVR/M casks. The baskets of large capacity were designed and fabricated for SKODA VPVR/M casks. Special requirements to drying the packages and composition of gaseous medium inside were justified to ensure fire and explosion safety. Specialized ISO-containers and transfer equipment designed under Romanian Project were used together with TUK-19 casks. A forklift and mobile rail system were used to handle SKODA VPVR/M casks under conditions of low capacity of the cranes at the facility. Due to the tight schedule of RRRFR Program as well as geographical peculiarities of RA

  18. Existing facilities and past practices: Lessons learned

    International Nuclear Information System (INIS)

    Huizenga, D.; Tonkay, D.W.; Owens, K.

    2000-01-01

    Article 12 of the Joint Convention on the Safety of Spent Fuel Management and on the Safety of Radioactive Waste Management (Joint Convention) requires parties to the Joint Convention to review the safety of existing radioactive waste management facilities 'to ensure that, if necessary, all reasonably practicable improvements are made to upgrade the safety of such a facility'. Also required is a review of the results of past practices to determine 'whether any intervention is needed for reasons of radiation protection' and to consider whether the benefits of the intervention or remediation are sufficient, with regard to the costs and the impact on workers, the public and the environment. This paper discusses the experience of the United States Department of Energy in terms of the lessons learned from operating radioactive waste management facilities and from undertaking intervention or remedial action, and from decision making in an international context. Overarching safety principles are discussed, including integrating safety into all work practices and minimizing the generation of waste. Safety review lessons learned with existing facilities are discussed with respect to: applying new requirements to old facilities, taking a life-cycle perspective of waste management, improving high level waste facility management, and blending current and past practices with respect to the process used to arrive at decisions for intervention. Special emphasis is placed on the need to provide for early and substantive input from the involved regulatory agencies, Native American tribes, and those citizens and groups with an interest in the decisions. Examples of intervention decisions are discussed, including examples taken from uranium mill tailings operations, from cleanup of a former uranium processing plant site, from evaluation of pre-1970 buried 'transuranic waste' sites, and from decommissioning or closure of high level waste storage tanks. The paper concludes that on the

  19. Calibration Lessons Learned from Hyperion Experience

    Science.gov (United States)

    Casement, S.; Ho, K.; Sandor-Leahy, S.; Biggar, S.; Czapla-Myers, J.; McCorkel, J.; Thome, K.

    2009-12-01

    The use of hyperspectral imagers to provide climate-quality data sets, such as those expected from the solar reflective sensor on the Climate Absolute Radiance and Refractivity Observatory (CLARREO), requires stringent radiometric calibration requirements. These stringent requirements have been nearly met with broadband radiometers such as CERES, but high resolution spectrometers pose additional challenges. A review of the calibration processes for past space-based HSIs provide guidance on the calibration processes that will be needed for future sensors. In November 2000, the Earth Observer-1 (EO-1) platform was launched onboard a Boeing Delta II launch vehicle. The primary purpose of the EO-1 mission was to provide a technological testbed for spaceborne components. The platform has three sensors onboard, of which, the hyperspectral imager (HSI) Hyperion, is discussed here. The Hyperion sensor at the time had no comparable sensor in earth orbit, being the first grating-based, hyperspectral, civilian sensor in earth orbit. Ground and on-orbit calibration procedures including all cross-calibration activities have achieved an estimated instrument absolute radiometric error of 2.9% in the Visible channel (0.4 - 1.0 microns) and 3.4% in the shortwave infrared (SWIR, 0.9 - 2.5 microns) channel (EO-1/Hyperion Early Orbit Checkout Report Part II On-Orbit Performance Verification and Calibration). This paper describes the key components of the Hyperion calibration process that are applicable to future HSI missions. The pre-launch methods relied on then newly-developed, detector-based methods. Subsequent vicarious methods including cross-calibration with other sensors and the reflectance-based method showed significant differences from the prelaunch calibration. Such a difference demonstrated the importance of the vicarious methods as well as pointing to areas for improvement in the prelaunch methods. We also identify areas where lessons learned from Hyperion regarding

  20. Refueling Infrastructure for Alternative Fuel Vehicles: Lessons Learned for Hydrogen; Workshop Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Melaina, M. W.; McQueen, S.; Brinch, J.

    2008-07-01

    DOE sponsored the Refueling Infrastructure for Alternative Fuel Vehicles: Lessons Learned for Hydrogen workshop to understand how lessons from past experiences can inform future efforts to commercialize hydrogen vehicles. This report contains the proceedings from the workshop.

  1. A summary of lessons learned at the Shippingport Station Decommissioning Project (SSDP)

    International Nuclear Information System (INIS)

    Crimi, F.P.; Mullee, G.R.

    1987-10-01

    This paper describes the lessons learned from a management perspective during decommissioning. The lessons learned are presented in a chronological sequence during the life of the project up to the present time. The careful analysis of the lessons learned and the implementation of corresponding actions have contributed toward improving the effectiveness of decommissioning as time progresses. The lessons learned should be helpful in planning future decommissioning projects

  2. Noncombatant Evacuation Operations: Department of State’s Lessons Learned Program

    Science.gov (United States)

    2016-06-10

    means for utilizing the lessons learned, in some form of rehearsal or exercise, will 4 make the lessons learned meaningful. A lesson should only...required by DOS policy. The Department agreed with the recommendations to establish certain procedures to address the need to constantly 44 update...doctrine.31 Futch also explained that CALL is constantly seeking to expand training and educational efforts about the lessons learned process and

  3. Refining MARGINS Mini-Lessons Using Classroom Observations

    Science.gov (United States)

    Iverson, E. A.; Manduca, C. A.; McDaris, J. R.; Lee, S.

    2009-12-01

    One of the challenges that we face in developing teaching materials or activities from research findings is testing the materials to determine that they work as intended. Traditionally faculty develop material for their own class, notice what worked and didn’t, and improve them the next year. However, as we move to a community process of creating and sharing teaching materials, a community-based process for testing materials is appropriate. The MARGINS project has piloted such a process for testing teaching materials and activities developed as part of its mini-lesson project (http://serc.carleton.edu/margins/index.html). Building on prior work developing mechanisms for community review of teaching resources (e.g. Kastens, 2002; Hancock and Manduca, 2005; Mayhew and Hall, 2007), the MARGINS evaluation team developed a structured classroom observation protocol. The goals of field testing are to a) gather structured, consistent feedback for the lesson authors based on classroom use; b) guide reviewers of these lessons to reflect on research-based educational practice as a framework for their comments; c) collect information on the data and observations that the reviewer used to underpin their review; d) determine which mini-lessons are ready to be made widely available on the website. The protocol guides faculty observations on why they used the activity, the effectiveness of the activity in their classroom, the success of the activity in leading to the desired learning, and what other faculty need to successfully use the activity. Available online (http://serc.carleton.edu/margins/protocol.html), the protocol can be downloaded and completed during instruction with the activity. In order to encourage review of mini-lessons using the protocol, a workshop focused on review and revision of activities was held in May 2009. In preparation for the workshop, 13 of the 28 participants chose to field test a mini-lesson prior to the workshop and reported that they found this

  4. Chinese haze versus Western smog: lessons learned.

    Science.gov (United States)

    Zhang, Junfeng Jim; Samet, Jonathan M

    2015-01-01

    Air pollution in many Chinese cities has been so severe in recent years that a special terminology, the "Chinese haze", was created to describe China's air quality problem. Historically, the problem of Chinese haze has developed several decades after Western high-income countries have significantly improved their air quality from the smog-laden days in the early- and mid-20(th) century. Hence it is important to provide a global and historical perspective to help China combat the current air pollution problems. In this regard, this article addresses the followings specific questions: (I) What is the Chinese haze in comparison with the sulfurous (London-type) smog and the photochemical (Los Angeles-type) smog? (II) How does Chinese haze fit into the current trend of global air pollution transition? (III) What are the major mitigation measures that have improved air quality in Western countries? and (IV) What specific recommendations for China can be derived from lessons and experiences from Western countries?

  5. The real leadership lessons of Steve Jobs.

    Science.gov (United States)

    Isaacson, Walter

    2012-04-01

    The author, whose biography of Steve Jobs was an instant best seller after the Apple CEO's death in October 2011, sets out here to correct what he perceives as an undue fixation by many commentators on the rough edges of Jobs's personality. That personality was integral to his way of doing business, Isaacson writes, but the real lessons from Steve Jobs come from what he actually accomplished. He built the world's most valuable company, and along the way he helped to transform a number of industries: personal computing, animated movies, music, phones, tablet computing, retail stores, and digital publishing. In this essay Isaacson describes the 14 imperatives behind Jobs's approach: focus; simplify; take responsibility end to end; when behind, leapfrog; put products before profits; don't be a slave to focus groups; bend reality; impute; push for perfection; know both the big picture and the details; tolerate only "A" players; engage face-to-face; combine the humanities with the sciences; and "stay hungry, stay foolish."

  6. Lessons Learned in Risk Management on NCSX

    International Nuclear Information System (INIS)

    Neilson, G.H.; Gruber, C.O.; Harris, Jeffrey H.; Rej, D.J.; Simmons, R.T.; Strykowsky, R.L.

    2010-01-01

    The National Compact Stellarator Experiment (NCSX) was designed to test physics principles of an innovative stellarator design developed by Princeton Plasma Physics Laboratory and Oak Ridge National Laboratory. Construction of some of the major components and subassemblies was completed, but the estimated cost and schedule for completing the project grew as the technical requirements and risks became better understood, leading to its cancellation in 2008. The project's risks stemmed from its technical challenges, primarily the complex component geometries and tight tolerances that were required. The initial baseline, which was established in 2004, was supported by a risk management plan and risk-based contingencies, both of which proved to be inadequate. Technical successes were achieved in the construction of challenging components and subassemblies, but cost and schedule growth was experienced. As part of an effort to improve project performance, a new risk management program was devised and implemented in 2007-2008. It led to a better understanding of project risks, a sounder basis for contingency estimates, and improved management tools. Although the risks were ultimately unacceptable to the sponsor, valuable lessons in risk management were learned through the experiences with the NCSX project.

  7. Media advocacy: lessons from community experiences.

    Science.gov (United States)

    Jernigan, D H; Wright, P A

    1996-01-01

    Media advocacy is the strategic use of mass media and community organizing as a resource for advancing a social or public policy initiative. Across the United States, communities are using media advocacy to promote healthier public policies and environments. The U.S. Center for Substance Abuse Prevention commissioned numerous case studies of media advocacy on alcohol and tobacco issues in a diverse array of communities, including efforts in African-American and Latino communities or using computer-based electronic communication systems. The paper describes these efforts briefly, and summarizes lessons learned, including: media advocacy can lead to larger victories when used as a complement to community organizing in the context of a larger strategic vision for policy change; like policy advocacy, media advocacy is best done in the context of clear long-term goals; conscious framing, guiding the choice of spokespeople, visuals, and messages, can alter media coverage and public debate of health policies; advocates need to respect the media but also remember that they have power in relation to the media; and media advocacy is often controversial and not suited to every situation. The case studies show that media advocacy is a potent tool for public health workers, making an important contribution to campaigns to promote healthier public policies.

  8. Four lessons on Randstad-Holland

    Directory of Open Access Journals (Sweden)

    Joan Moreno

    2014-10-01

    Full Text Available The Dutch delta, at the confluence of the courses of the Rhine, Meuse and Scheldt rivers, is the paradigmatic territory of networks from the earliest stages of the human settlement. In an unsteady landscape, made up of a mosaic of marshes, bogs and sand dunes; irrigated by a maze with rivers, streams and canals; transportation network is the element that strengthens and unites the urban structure for centuries. This article discusses the integration of the Dutch transport network and the urban network from four noted episodes in the history of mobility in the Netherlands: the Trekvaarten [towpaths], the Oude Lijn [Old railway line], the Halsketting [nodal corridor], and finally, the intermodal center Zuidas-Amsterdam. The aim of this article is to show how the development of the Dutch urban network is conditioned by structural changes in the transportation network, and how the evolution of the urban mobility system determines simultaneously both: regional and local spheres. Ultimately, four lessons in mobility and urbanity in the Randstad-Holland that take the case of study further and are a model in the development of an integrated metropolitan system.

  9. The German Chernobyl project: Lessons learned

    International Nuclear Information System (INIS)

    Hill, P.; Hille, R.

    1999-01-01

    This report presents results and lessons learned by one of the so far largest assessments of a post-accidental situation. Funded by the Federal Republic of Germany the German Chernobyl Project investigated in the years 1991-1993 the radiological situation in contaminated regions of the Russian Federation, Belarus and Ukraine. Measurements included a mass screening of the population in order to determine the Cesium body burdens of 250,000+ individuals in more than 240 settlements as well as the evaluation of external doses in selected settlements with soil contaminations varying from less than 74 kBq/m 2 to about 3700 kBq/m 2 including some, where decontamination measures had previously been taken. Also in many settlements environmental monitoring was undertaken. For most individuals doses did not exceed the international annual limits set for the general population. Open and comprehensive communication of results was favourably accepted by the public. In a few settlements the radiological situation has been followed up till to date. (author)

  10. Transradial access: lessons learned from cardiology.

    Science.gov (United States)

    Snelling, Brian M; Sur, Samir; Shah, Sumedh Subodh; Marlow, Megan M; Cohen, Mauricio G; Peterson, Eric C

    2018-05-01

    Innovations in interventional cardiology historically predate those in neuro-intervention. As such, studying trends in interventional cardiology can be useful in exploring avenues to optimise neuro-interventional techniques. One such cardiology innovation has been the steady conversion of arterial puncture sites from transfemoral access (TFA) to transradial access (TRA), a paradigm shift supported by safety benefits for patients. While neuro-intervention has unique anatomical challenges, the access itself is identical. As such, examining the extensive cardiology literature on the radial approach has the potential to offer valuable lessons for the neuro-interventionalist audience who may be unfamiliar with this body of work. Therefore, we present here a report, particularly for neuro-interventionalists, regarding the best practices for TRA by reviewing the relevant cardiology literature. We focused our review on the data most relevant to our audience, namely that surrounding the access itself. By reviewing the cardiology literature on metrics such as safety profiles, cost and patient satisfaction differences between TFA and TRA, as well as examining the technical nuances of the procedure and post-procedural care, we hope to give physicians treating complex cerebrovascular disease a broader data-driven understanding of TRA. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  11. Marketing healthcare: lessons for smaller hospitals.

    Science.gov (United States)

    Chowdhary, N R

    2000-02-01

    Recently, I have noted ubiquitous trends that lead me to conclude that we are on the brink of a fundamental change in the structure of healthcare delivery. Hospitals are changing. The hospital, that enduring and pervasive organization, which for decades has delivered the vast majority of acute care services is being re-conceptualized. Administrators and executives in today's hospitals are beginning to recognize the disaffection of constituents and the necessity to change from placing their own agenda or that of their profession over the needs of the customer. A lesson that is increasingly being heeded, particularly by the leading hospitals, is that a belief in one's own importance or a feeling of invulnerability represents an anachronistic stance. No hospital today can afford to retain a view that it is more important than the patients it serves, or that it is invulnerable. The external pressures are already clear--the actors, factors and forces in the external environment are forcing hospitals to re-evaluate efficiency, effectiveness and delivery arrangements. The rise to prominence of the outcomes movement is part of this trend. The present study was an attempt to assess the practices and trends in the modern smaller hospitals as a part of their strategy to match the competitive pressures.

  12. Lessons Learned in Risk Management on NCSX

    International Nuclear Information System (INIS)

    Neilson, G.H.; Gruber, C.O.; Harris, J.H.; Rej, D.J.; Simmons, R.T.; Strykowsky, R.L.

    2009-01-01

    The National Compact Stellarator Experiment (NCSX) was designed to test physics principles of an innovative stellarator design developed by the Princeton Plasma Physics Laboratory and Oak Ridge National Laboratory. Construction of some of the major components and sub-assemblies was completed, but the estimated cost and schedule for completing the project grew as the technical requirements and risks became better understood, leading to its cancellation in 2008. The project's risks stemmed from its technical challenges, primarily the complex component geometries and tight tolerances that were required. The initial baseline, established in 2004, was supported by a risk management plan and risk-based contingencies, both of which proved to be inadequate. Technical successes were achieved in the construction of challenging components and subassemblies, but cost and schedule growth was experienced. As part of an effort to improve project performance, a new risk management program was devised and implemented in 2007-08. It led to a better understanding of project risks, a sounder basis for contingency estimates, and improved management tools. Although the risks ultimately were unacceptable to the sponsor, valuable lessons in risk management were learned through the experiences with the NCSX project

  13. Value-Based Requirements Traceability: Lessons Learned

    Science.gov (United States)

    Egyed, Alexander; Grünbacher, Paul; Heindl, Matthias; Biffl, Stefan

    Traceability from requirements to code is mandated by numerous software development standards. These standards, however, are not explicit about the appropriate level of quality of trace links. From a technical perspective, trace quality should meet the needs of the intended trace utilizations. Unfortunately, long-term trace utilizations are typically unknown at the time of trace acquisition which represents a dilemma for many companies. This chapter suggests ways to balance the cost and benefits of requirements traceability. We present data from three case studies demonstrating that trace acquisition requires broad coverage but can tolerate imprecision. With this trade-off our lessons learned suggest a traceability strategy that (1) provides trace links more quickly, (2) refines trace links according to user-defined value considerations, and (3) supports the later refinement of trace links in case the initial value consideration has changed over time. The scope of our work considers the entire life cycle of traceability instead of just the creation of trace links.

  14. Forest fires in 2017: a useful lesson

    Directory of Open Access Journals (Sweden)

    Battipaglia G

    2017-08-01

    Full Text Available Forest fires in 2017: a useful lesson. Forest fires, together with the decline of silviculture practice, are one of the most important natural disturbances affecting Mediterranean forests. The year 2017 is shaping up to be a record breaking fire season all around Southern Europe and especially in Italy for the sheer amount of hectares burned. Here we discuss about the importance of forest fire management, highlighting the role of prescribed burning and mechanical treatment (e.g., manual removal, thinning in reducing the risk of high-intensity wildfires. We report on the successful applications of those fire management techniques on the pinewoods of Vesuvio National Park and Castel Fusano Natural Reserve. The information compiled in the present article aims to demonstrate the potential relevance and impact of forest resources management for fire hazard reduction and shows the necessity of strong interaction among not only the scientific community, but also forest managers, decision makers and the civic responsibility of society at large.

  15. Lessons from the Fukushima nuclear power accident

    International Nuclear Information System (INIS)

    Hatamura, Yotaro

    2013-01-01

    Through the investigation of the Fukushima Nuclear Power Accident as the chairman of the related Government's Committee, many things had been considered. Essence of the accident could be not only what occurred in the Fukushima nuclear power station, but also dispersed radioactive materials forced many residents to move and not to be returned. Such events as indication errors of water level meter occurring in severe accident could no be thought and remote mechanical operation of valves under high radiation environment were not prepared. Contamination by radioactive clouds caused the evacuation of residents for a long period. Lessons learned from the accident were described such as; (1) the verification of the road to failure connecting selected accident sequence and road to success with another supposed choice, (2) considering what might occur and then what should be needed on the contrary, (3) nuclear power, if should be continued, should be used with the premise of its hazards, and (4) advise to nuclear engineer for adequate information dissemination and technical explanation to the public and keeping nuclear technologies alive. (T. Tanaka)

  16. Intelligence and Nuclear Proliferation: Lessons Learned

    International Nuclear Information System (INIS)

    Hansen, Keith A.

    2011-09-01

    Intelligence agencies play a fundamental role in the prevention of nuclear proliferation, as they help to understand other countries' intentions and assess their technical capabilities and the nature of their nuclear activities. The challenges in this area remain, however, formidable. Past experiences and the discoveries of Iraq's WMD programs, of North Korean nuclear weapon program, and of Iranian activities, have put into question the ability of intelligence to monitor small, clandestine proliferation activities from either states or non-state entities. This Proliferation Paper analyzes the complex challenges intelligence faces and the various roles it plays in supporting national and international nuclear non-proliferation efforts, and reviews its track record. In an effort to shed light on the role and contribution of intelligence in national and international efforts to halt, if not prevent, further nuclear weapon proliferation, this paper first analyzes the challenges intelligence faces in monitoring small, clandestine proliferation activities and the role it plays in supporting non-proliferation efforts. It then reviews the intelligence track record in monitoring proliferation including the lessons learned from Iraq. Finally, it addresses whether it is possible for intelligence to accurately monitor future clandestine proliferation efforts. (author)

  17. Lessons for the control of AIDS.

    Science.gov (United States)

    Weller, T H

    1987-11-15

    A balanced perspective that places acquired immunodeficiency syndrome (AIDS) in the context of the social needs of a global society is needed to overcome the hysteria and stigmatizing that presently surrounds this public health issue. The migration of poor, rural, sexually active young people to urban centers in the Third World has clearly played a role in the dissemination of AIDS and other infectious diseases. It is necessary, however, to examine the major cause of such population movement--private enterprise. Migrant workers are used to perform menial jobs in the urban labor force. Another cause of population movements is war and political repression. The fact that young people are becoming increasingly mobile has serious implications for the control of AIDS, and this phenomenon cannot be addressed without looking at its causes. Similarly, the disproportionate mortality of minorities- -seen in the AIDS epidemic as well--calls for discrimination. To prevent and control AIDS, the 1st step is to increase understanding of its natural history and epidemiology. Then, lessons must be learned from successful public health programs rooted in a primary health care system, including the Expanded Program on Immunization and oral rehydration campaigns. Although funds should not be diverted from such programs to combat AIDS, their logistic structure should be studied. Above all, however, it must be kept in mind that the constructive influence of health education will be thwarted as long as social inequities remain.

  18. The Tamiflu fiasco and lessons learnt.

    Science.gov (United States)

    Gupta, Yogendra Kumar; Meenu, Meenakshi; Mohan, Prafull

    2015-01-01

    Oseltamivir (Tamiflu), a neuraminidase inhibitor, was approved for seasonal flu by US Food and Drug Administration in 1999. A number of randomized controlled trials, systematic reviews, and meta-analysis emphasized a favorable efficacy and safety profile. Majority of them were funded by Roche, which also first marketed and promoted this drug. In 2005 and 2009, the looming fear of pandemic flu led to recommendation by prominent regulatory bodies such as World Health Organization (WHO), Centers for Disease Control and Prevention, European Medicines Agency and others for its use in treatment and prophylaxis of influenza, and it's stockpiling as a measure to tide over the crisis. Serious Adverse Events, especially neuropsychiatric events associated with Tamiflu started getting reported leading to a cascade of questions on clinical utility of this drug. A recent Cochrane review and related articles have questioned the risk-benefit ratio of the drug, besides raising doubts about the regulatory decision of approving it. The recommendations for stockpiling the said drug as given by various international organizations viz WHO have also been put to scrutiny. Although many reviewers have labeled the Tamiflu saga as a "costly mistake," the episode leaves us with some important lessons. This article takes a comprehensive relook on the subject, and we proceed to suggest some ways and means to avoid a similar situation in the future.

  19. Cellular uptake: lessons from supramolecular organic chemistry.

    Science.gov (United States)

    Gasparini, Giulio; Bang, Eun-Kyoung; Montenegro, Javier; Matile, Stefan

    2015-07-04

    The objective of this Feature Article is to reflect on the importance of established and emerging principles of supramolecular organic chemistry to address one of the most persistent problems in life sciences. The main topic is dynamic covalent chemistry on cell surfaces, particularly disulfide exchange for thiol-mediated uptake. Examples of boronate and hydrazone exchange are added for contrast, comparison and completion. Of equal importance are the discussions of proximity effects in polyions and counterion hopping, and more recent highlights on ring tension and ion pair-π interactions. These lessons from supramolecular organic chemistry apply to cell-penetrating peptides, particularly the origin of "arginine magic" and the "pyrenebutyrate trick," and the currently emerging complementary "disulfide magic" with cell-penetrating poly(disulfide)s. They further extend to the voltage gating of neuronal potassium channels, gene transfection, and the delivery of siRNA. The collected examples illustrate that the input from conceptually innovative chemistry is essential to address the true challenges in biology beyond incremental progress and random screening.

  20. Lessons learned in NEPA public involvement

    International Nuclear Information System (INIS)

    Stevens, A.D.; Glore, D.M.

    1995-01-01

    'In recent years Uncle Sam has been asking citizens for their help in improving the environment. The government is learning that with public input it can better prioritize environmental problems and more effectively direct limited funding.' The National Environmental Policy Act (NEPA), like many other government regulations, is a 'living law.' Although there are agency and Council guidelines, it is practical application, based on past practices and case law that refines the Act's broad concepts. The specifics of how to meet requirements are constantly being honed and melded to fit the unique situational needs of an agency, a project, or a public. This fluidity presents a challenge for stakeholder involvement activities. Communication practioners and project managers may have room for creativity and customized approaches, but they also find less than clear direction on what it takes to successfully avoid challenges of non-compliance. Because of the continuing uncertainty on how to involve the public meaningfully, it is vital to share important lessons learned from NEPA projects. The following practical suggestions are derived primarily from experiences with the Department of Energy's first ever complex-wide and site-specific environmental impact statement (EIS)-the Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs EIS (SNF ampersand INEL EIS)

  1. Lessons learnt from Ignalina NPP decommissioning project

    International Nuclear Information System (INIS)

    NAISSE, Jean-Claude

    2007-01-01

    The Ignalina Nuclear Power Plant (INPP) is located in Lithuania, 130 km north of Vilnius, and consists of two 1500 MWe RBMK type units, commissioned respectively in December 1983 and August 1987. On the 1. of May 2004, the Republic of Lithuania became a member of the European Union. With the protocol on the Ignalina Nuclear Power in Lithuania which is annexed to the Accession Treaty, the Contracting Parties have agreed: - On Lithuanian side, to commit closure of unit 1 of INPP before 2005 and of Unit 2 by 31 December 2009; - On European Union side, to provide adequate additional Community assistance to the efforts of Lithuania to decommission INPP. The paper is divided in two parts. The first part describes how, starting from this agreement, the project was launched and organized, what is its present status and which activities are planned to reach the final ambitious objective of a green field. To give a global picture, the content of the different projects that were defined and the licensing process will also be presented. In the second part, the paper will focus on the lessons learnt. It will explain the difficulties encountered to define the decommissioning strategy, considering both immediate or differed dismantling options and why the first option was finally selected. The paper will mention other challenges and problems that the different actors of the project faced and how they were managed and solved. The paper will be written by representatives of the Ignalina NPP and of the Project Management Unit. (author)

  2. Effective Lesson Planning: Field Trips in the Science Curriculum

    Science.gov (United States)

    Rieger, C. R.

    2010-10-01

    Science field trips can positively impact and motivate students. However, if a field trip is not executed properly, with appropriate preparation and follow-up reinforcement, it can result in a loss of valuable educational time and promote misconceptions in the students. This study was undertaken to determine if a classroom lesson before an out-of-the-classroom activity would affect learner gain more or less than a lesson after the activity. The study was based on the immersive theater movie ``Earth's Wild Ride'' coupled with a teacher-led Power Point lesson. The participants in the study were students in a sixth grade physical science class. The order of lessons showed no detectable effect on final learner outcomes. Based on pre- and post-testing, improvement in mean learning gain came from the teacher-led lesson independent of the movie. The visit to the immersive theater, however, had significant positive effects that did not show up in the quantitative results of the testing.

  3. Design Lessons Drawn from the Decommissioning of Nuclear Facilities

    International Nuclear Information System (INIS)

    2011-05-01

    This report provides an updated compilation incorporating the most recent lessons learned from decommissioning and remediation projects. It is intended as a 'road map' to those seeking to apply these lessons. The report presents the issues in a concise and systematic manner, along with practical, thought-provoking examples. The most important lessons learned in recent years are organized and examined to enable the intended audience to gauge the importance of this aspect of the planning for new nuclear facilities. These will be of special interest to those seeking to construct nuclear facilities for the first time. In Sections 1 and 2, the current situation in the field of decommissioning is reviewed and the relevance and importance of beneficial design features is introduced. A more detailed review of previous and current lessons learned from decommissioning is given in Section 3 where different aspects of the decommissioning process are analysed. From this analysis beneficial design features have been extracted and identified in Section 4 which includes two comprehensive tables where brief descriptions of the features are summarized and responsibilities are identified. Conclusions and key design features and key recommendations are given in Section 5. Two Annexes are included to provide lessons from past projects and past experience and to record notes and extracts taken from a comprehensive list of publications listed in the References on page 47.

  4. Improving the primary school science learning unit about force and motion through lesson study

    Science.gov (United States)

    Phaikhumnam, Wuttichai; Yuenyong, Chokchai

    2018-01-01

    The study aimed to develop primary school science lesson plan based on inquiry cycle (5Es) through lesson study. The study focused on the development of 4 primary school science lesson plans of force and motion for Grade 3 students in KKU Demonstration Primary School (Suksasart), first semester of 2015 academic year. The methodology is mixed method. The Inthaprasitha (2010) lesson study cycle was implemented in group of KKU Demonstration Primary School. Instruments of reflection of lesson plan developing included participant observation, meeting and reflection report, lesson plan and other document. The instruments of examining students' learning include classroom observation and achievement test. Data was categorized from these instruments to find the issues of changing and improving the good lesson plan of Thai primary school science learning. The findings revealed that teachers could develop the lesson plans through lesson study. The issues of changing and improving were disused by considering on engaging students related to societal issues, students' prior knowledge, scientific concepts for primary school students, and what they learned from their changing. It indicated that the Lesson Study allowed primary school science teachers to share ideas and develop ideas to improve the lesson. The study may have implications for Thai science teacher education through Lesson Study.

  5. Do Students Really Understand Topology in the Lesson? A Case Study

    Science.gov (United States)

    Narli, Serkan

    2010-01-01

    This study aims to specify to what extent students understand topology during the lesson and to determine possible misconceptions. 14 teacher trainees registered at Secondary School Mathematics education department were observed in the topology lessons throughout a semester and data collected at the first topology lesson is presented here.…

  6. Key Elements of a Good Mathematics Lesson as Seen by Japanese Junior High School Teachers

    Science.gov (United States)

    Ebaeguin, Marlon; Stephens, Max

    2016-01-01

    This study makes a comparison between what literature on Japanese Lesson Study suggests are key elements of a good mathematics lesson and what junior high school mathematics teachers in Japan value in planning their lessons. The teachers' strong consensus in their endorsements of these key elements explains why Japanese teachers strongly support…

  7. A Marketing Approach to Evaluation: Four Lessons for Evaluators from the Honda Motor Company.

    Science.gov (United States)

    Mangano, Michael F.

    1992-01-01

    Describes lessons evaluators can learn from the Honda Motor Company and how an evaluation office within the Department of Health and Human Services has applied these lessons. The lessons include (1) sound market research; (2) creating top-notch production capabilities; (3) building a better mousetrap; and (4) aggressive product selling. (SLD)

  8. The learning teacher in a collaborative lesson study team within the context of mathematics

    NARCIS (Netherlands)

    Goei, Sui Lin; Verhoef, Neeltje Cornelia

    2015-01-01

    This paper summarises results of two studies on teachers’ learning when participating in a collaborative Lesson Study team within the context of mathematics teaching. In study one, Lesson Study was used in the classic way of preparing, designing, executing and reflecting on the research lesson.

  9. The Level and Quality of Accountability Talk in the Science Lessons

    Science.gov (United States)

    Motlhabane, Abraham

    2016-01-01

    Teachers are actively encouraged to plan their lessons such that there is maximum classroom talk, namely accountability talk. However, many lessons do not display sufficient accountability talk. This study attempted to better understand the level and quality of accountability talk in six science lessons. The study aimed to provide teachers with…

  10. From Autopsy to Biopsy: A Metacognitive View of Lesson Planning and Teacher Trainees in ELT

    Science.gov (United States)

    Liyanage, Indika; Bartlett, Brendan John

    2010-01-01

    Lesson planning and implementation of those plans are complex and cognitively demanding for English Language Teacher trainees preparing for the profession. Many find it difficult to develop a lesson holistically and to maintain alignment across aims, procedural steps, and evaluation when planning and implementing a lesson. We attempted to address…

  11. Exploring the Content of Instrumental Lessons and Gender Relations in Australian Higher Education

    Science.gov (United States)

    Zhukov, Katie

    2008-01-01

    This observational study analysed the lesson content of 24 instrumental lessons (piano, strings and winds) using a gender-balanced sample (equal numbers of male/female teachers and students) from five Australian higher education institutions to ascertain the priorities of topics in advanced applied music lessons in the Western Classical tradition.…

  12. Preventing Unplanned Pregnancy and Completing College: An Evaluation of Online Lessons. 2nd Edition

    Science.gov (United States)

    Antonishak, Jill; Connolly, Chelsey

    2014-01-01

    The National Campaign to Prevent Teen and Unplanned Pregnancy published free online lessons that help students take action to prevent unplanned pregnancy and complete their education. From the fall of 2012 to the spring of 2014, approximately 2,800 students took the online lessons and participated in pre- and post-lesson evaluation surveys at four…

  13. How to Analyze Routines in Teachers' Thinking Processes during Lesson Planning.

    Science.gov (United States)

    Bromme, Rainer

    A justification for the study of teachers' routines, as they affect the preparation of lesson plans, prefaces this paper on teachers' thought processes during lesson planning. In focusing on the importance of research into teachers' routines, it is pointed out that lesson preparation and classroom routines permit teachers to direct attention to…

  14. The Key Factors Affecting Students' Individual Interest in School Science Lessons

    Science.gov (United States)

    Cheung, Derek

    2018-01-01

    Individual interest in school science lessons can be defined as a relatively stable and enduring personal emotion comprising affective and behavioural reactions to events in the regular science lessons at school. Little research has compared the importance of different factors affecting students' individual interest in school science lessons. The…

  15. Martin Luther King, Jr.: A Lesson with Interdisciplinary Connections for Middle-Level Music Students.

    Science.gov (United States)

    Early, Mary Frances; Terry, Cynthia

    This lesson begins with a very brief biography of Martin Luther King, Jr. The lesson identifies its educational objectives; addresses National Standards for Music Education; lists materials needed; details six step-by-step classroom procedures for lesson implementation; and provides curriculum connections for language arts, visual art, physical…

  16. Lessons from Our Kissing Cousins: Third Culture Kids and Gifted Children

    Science.gov (United States)

    Sheard, Wenda

    2008-01-01

    This article describes characteristics shared by "third culture kids" (TCKs) and gifted children and summarizes lessons to be learned from the two communities. Some of the lessons are from TCKs themselves; the article includes quotes from students the author has taught in recent years. Pedagogical lessons for raising the global awareness…

  17. Influences of Multimedia Lesson Contents On Effective Learning

    Directory of Open Access Journals (Sweden)

    Tuncay Yavuz Ozdemir

    2013-11-01

    Full Text Available In the information era that we experience today, there is a rapid change in the methods, techniques and materials used for education and teaching. The usage of information and communication technology-assisted teaching materials are becoming more commonplace. Parallel to these developments, the Ministry of National Education took steps to develop IT substructures of all schools in the country and implemented many projects. The purpose of this study is to determine whether or not the multimedia lesson content used by teachers affect effective learning. This study is a qualitative study, conducted with 45 teachers working in primary schools during the 2011-2012 academic year. According to the study findings, participants believe that using multimedia lesson content during lectures increases student motivation, makes students more curious and interested, and think that using multimedia lesson content has positive effects.

  18. The relationships within the mathematical content of teachers’ lesson sequences

    Science.gov (United States)

    Shahrill, M.; Prahmana, R. C. I.; Roslan, R.

    2017-12-01

    This study explored how mathematics content is carried through by means of the problems presented during lessons. Following the definitions and the coding criteria from the TIMSS 1999 Video Study, a total of 163 mathematics problems were identified in the video- recorded lesson sequences of four Bruneian mathematics teachers teaching at the Year 8 level. These problems were classified according to the four basic kinds of relationships: mathematically related, thematically related, repetition and unrelated. Drawing on the mathematical content of the teachers’ lesson sequences, the findings revealed variations among the mathematical problems coded as repetition and thematically related, between the four Brunei classes. The aggregated results obtained from the four classes highlighted several points of discussion, such as the relatively higher proportion of repetition problems (52%) from one teacher in particular; the percentage similarities of thematically related problems for all four classes (ranging from 26% to 33%); and the incredibly varied results for mathematically related problems across the four Brunei classes.

  19. Lessons learned from radiological accidents at medical exposures in radiotherapy

    International Nuclear Information System (INIS)

    Fagundes, J.S.; Ferreira, A.F.; Lima, C.M.A.; Silva, F.C.A. da

    2017-01-01

    An exposure is considered accidental in radiotherapy when there is a substantial deviation in the prescription of treatment. In this work, an analysis of published radiological accidents, both in Brazil and internationally, was performed during medical exposures in radiotherapy treatments, removing the main lessons learned. Of the research carried out, we highlight Brazil with four radiological accidents and one death in the period between 2011 and 2014; the United States of America with 169 accidents with two deaths from 2000 to 2010 and France from 2001 to 2014 had 569 deaths without patients. Lessons learned have been described, for example, that maintenance personnel training should specify limitations or restrictions on the handling or adjustment of critical parts on the accelerator. It is recommended to apply the 10 main lessons learned due to radiological accidents during medical exposures in radiotherapy treatments to avoid future events

  20. Graduate students teaching elementary earth science through interactive classroom lessons

    Science.gov (United States)

    Caswell, T. E.; Goudge, T. A.; Jawin, E. R.; Robinson, F.

    2014-12-01

    Since 2005, graduate students in the Brown University Department of Earth, Environmental, and Planetary Studies have volunteered to teach science to second-grade students at Vartan Gregorian Elementary School in Providence, RI. Initially developed to bring science into classrooms where it was not explicitly included in the curriculum, the graduate student-run program today incorporates the Providence Public Schools Grade 2 science curriculum into weekly, interactive sessions that engage the students in hypothesis-driven science. We will describe the program structure, its integration into the Providence Public Schools curriculum, and 3 example lessons relevant to geology. Lessons are structured to develop the students' ability to share and incorporate others' ideas through written and oral communication. The volunteers explain the basics of the topic and engage the students with introductory questions. The students use this knowledge to develop a hypothesis about the upcoming experiment, recording it in their "Science Notebooks." The students record their observations during the demonstration and discuss the results as a group. The process culminates in the students using their own words to summarize what they learned. Activities of particular interest to educators in geoscience are called "Volcanoes!", "The "Liquid Race," and "Phases of the Moon." The "Volcanoes!" lesson explores explosive vs. effusive volcanism using two simulated volcanoes: one explosive, using Mentos and Diet Coke, and one effusive, using vinegar and baking soda (in model volcanoes that the students construct in teams). In "Liquid Race," which explores viscosity and can be integrated into the "Volcanoes!" lesson, the students connect viscosity to flow speed by racing liquids down a ramp. "Phases of the Moon" teaches the students why the Moon has phases, using ball and stick models, and the terminology of the lunar phases using cream-filled cookies (e.g., Oreos). These lessons, among many others

  1. Stand-alone photovoltaic applications. Lessons learned

    International Nuclear Information System (INIS)

    Loois, G.; Van Hemert, B.

    1999-02-01

    The IEA Photovoltaic Power Systems Programme (PVPS) is one of the collaborative R and D agreements established within the IEA. The objective of Task III is to promote and facilitate the exchange of information and experiences in the field of PV Systems in Stand-alone and Island Applications (SAPV). The book focuses on the practical experiences gained, and does not aim to provide a complete manual on SAPV. When Task III started its activities in 1993, a collection of 50 'State of the art' projects was published in the book 'Examples of Stand-Alone Photovoltaic Systems'. This publication marked the base line for the work of the task. Now, in 1998, the showcases from each country demonstrate the lessons learned in five years of cooperation. The book consists of two parts. The first part contains eight chapters dealing with a specific aspect of stand-alone PV. The second part introduces 14 national showcase projects in a systematic presentation. Each chapter and showcase can be read independently from the rest of the book. Chapter 2, contributed by The Netherlands, analyses the market for stand-alone PV systems. It gives an overview of the 'traditional' application of stand-alone PV, which is the electrification of remote buildings and which has been addressed in depth in other publications. The focus is on the market niches of service applications that are also interesting for more densely populated areas, e.g. in industrialised countries. The United Kingdom illustrates the economic aspects in Chapter 3. Cost comparisons are made, but more important is the illustration of the non-financial considerations that make PV the preferred choice as a power source for many applications. Switzerland explores in Chapter 4 (financing aspects) different financing mechanisms, and financial policies used to overcome the initial cost barrier. Most of these approaches have been applied in developing countries rather than in the western world. Using various examples from all over the

  2. What lessons can history teach us about the Charcot foot?

    Science.gov (United States)

    Sanders, Lee J

    2008-01-01

    Regrettably, physicians today receive very little instruction in the history of medicine. Most health care providers have a very limited, contemporary knowledge of the condition that we know of as the Charcot foot. Yet, historical concepts of the pathogenesis and natural history of this condition provide us with important lessons that enhance our understanding, recognition, and management of this rare but debilitating neurogenic arthropathy. It is my belief that knowledge of the history of medicine provides us with a better understanding of present-day issues and clearer vision as we look to the future. This article describes some of the important lessons learned from the history of the Charcot foot.

  3. Experience with chemicals regulation - Lessons from the Danish LAS case

    DEFF Research Database (Denmark)

    Lauridsen, Pia Vestergaard; Røpke, Inge

    2006-01-01

    the understanding of how chemicals regulation is being shaped through social and political processes, and which lessons can be drawn regarding the effectiveness of different regulatory measures. We outline briefly the history of the chemicals regulation as a background for the detailed discussion of the case study......Chemicals regulation is under pressure for change, and lessons from former experience are important to inform the process. This paper is based on a case study of the Danish measures towards regulating a specific substance, Linear Alkylbenzene Sulphonate (LAS), and the case is used to deepen...

  4. Knowledge into action: Some lessons from the histories of hazards

    DEFF Research Database (Denmark)

    Hansen, Steffen Foss; Gee, D.

    fuels and nuclear power provide lessons for prudent actions on the potential hazards of emerging technologies such as from nanotechnology, GMO food, radio-frequency from mobile phones, and the new generation of nuclear plants (See “Late Lessons from Early Warnings” volume I and II from the European...... and engagement of the public. In this paper, we analyse these latter barriers to getting knowledge into action and illustrate some ways and means by which science and precautionary measures, including regulations, market based instruments, and increased awareness and engagement of the public, could be designed...

  5. Lessons learned from the NREL village power program

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, R.W. [National Renewable Energy Lab., Golden, CO (United States)

    1998-09-01

    Renewable energy solutions for village power applications can be economical, functional, and sustainable. Pilot projects are an appropriate step in the development of a commercially viable market for rural renewable energy solutions. Moreover, there are a significant number of rural electrification projects under way that employ various technologies, delivery mechanisms, and financing arrangements. These projects, if properly evaluated, communicated, and their lessons incorporated in future projects and programs, can lead the way to a future that includes a robust opportunity for cost-effective, renewable-based village power systems. This paper summarizes some of NREL`s recent experiences and lessons learned.

  6. Lessons Learned from the NREL Village Power Program

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, R.

    1998-07-01

    Renewable energy solutions for village power applications can be economical, functional, and sustainable. Pilot projects are an appropriate step in the development of a commercially viable market for rural renewable energy solutions. Moreover, there are a significant number of rural electrification projects under way that employ various technologies, delivery mechanisms, and financing arrangements. These projects, if properly evaluated, communicated, and their lessons incorporated in future projects and programs, can lead the way to a future that includes a robust opportunity for cost-effective, renewable-based village power systems. This paper summarizes some of NRELs recent experiences and lessons learned.

  7. Crisis communication. Lessons from 9/11.

    Science.gov (United States)

    Argenti, Paul

    2002-12-01

    The sheer enormity of last year's terrorist attacks on the World Trade Center and the Pentagon gave new meaning to the term "crisis management." Suddenly, companies near Ground Zero, as well as those more than a thousand miles away, needed a plan. Because the disasters disrupted established channels not only between businesses and customers but between businesses and employees, internal crisis-communications strategies that could be quickly implemented became a key responsibility of top management. Without these strategies, employees' trauma and confusion might have immobilized their firms and set their customers adrift. In this article, executives from a range of industries talk about how their companies, including Morgan Stanley, Oppenheimer Funds, American Airlines, Verizon, the New York Times, Dell, and Starbucks, went about restoring operations and morale. From his interviews with these individuals, author and management professor Paul Argenti was able to distill a number of lessons, each of which, he says, may "serve as guideposts for any company facing a crisis that undermines its employees' composure, confidence, or concentration." His advice to senior executives includes: Maintain high levels of visibility, so that employees are certain of top management's command of the situation and concern; establish contingency communication channels and work sites; strive to keep employees focused on the business itself, because a sense of usefulness enhances morale and good morale enhances usefulness; and ensure that employees have absorbed the firm's values, which will guide them as they cope with the unpredictable. The most forward-thinking leaders realize that managing a crisis-communications program requires the same dedication and resources they give to other dimensions of their business. More important, they realize that their employees always come first.

  8. Lessons learned from accidental exposures in radiotherapy

    International Nuclear Information System (INIS)

    2000-01-01

    The medical use of radiation is unique in that patients are intentionally exposed to radiation. The aim in radiation therapy is twofold: to deliver a dose and dose distribution that is adequate for tumour control, but which also minimizes complications in normal tissues. In therapeutic applications, the doses are high and a deviation from the prescribed dose may have severe or even fatal consequences. There is therefore a great need to ensure adequate radiation protection and safety in radiotherapy by verifying that all personnel involved are appropriately trained for their duties, that the equipment used meets relevant international specifications for radiation safety and that safety culture is embedded in routine activities in radiotherapy departments. Many individuals must interact and work together on highly technical measurements and calculations, and therefore the potential for mistakes is great. A review of the mistakes shows that most are due to human error. The International Basic Safety Standards for Protection against Ionizing Radiation and the Safety of Radiation Sources (IAEA Safety Series No. 115) require that a prompt investigation be conducted whenever an accidental medical exposure of patients occurs. The report of the investigation is to be disseminated to the appropriate parties so that lessons can be learned to prevent similar accidents or mitigate their consequences in the future. This Safety Report is a collection of a large number of events that may serve as a checklist against which to test the vulnerability of a facility to potential accidents, and to provide a basis for improving safety in the use of radiation in medical applications. A further purpose of this report is to encourage readers to develop a questioning and learning attitude, adopt measures for the prevention of accidents, and prepare for mitigation of the consequences of accidents if they occur

  9. Integrated Programme Control Systems: Lessons Learned

    Energy Technology Data Exchange (ETDEWEB)

    Brown, C. W. [Babcock International Group PLC (formerly UKAEA Ltd) B21 Forss, Thurso, Caithness, Scotland (United Kingdom)

    2013-08-15

    Dounreay was the UK's centre of fast reactor research and development from 1955 until 1994 and is now Scotland's largest nuclear clean up and demolition project. After four decades of research, Dounreay is now a site of construction, demolition and waste management, designed to return the site to as near as practicable to its original condition. Dounreay has a turnover in the region of Pounds 150 million a year and employs approximately 900 people. It subcontracts work to 50 or so companies in the supply chain and this provides employment for a similar number of people. The plan for decommissioning the site anticipates all redundant buildings will be cleared in the short term. The target date to achieve interim end state by 2039 is being reviewed in light of Government funding constraints, and will be subject to change through the NDA led site management competition. In the longer term, controls will be put in place on the use of contaminated land until 2300. In supporting the planning, management and organisational aspects for this complex decommissioning programme an integrated programme controls system has been developed and deployed. This consists of a combination of commercial and bespoke tools integrated to support all aspects of programme management, namely scope, schedule, cost, estimating and risk in order to provide baseline and performance management data based upon the application of earned value management principles. Through system evolution and lessons learned, the main benefits of this approach are management data consistency, rapid communication of live information, and increased granularity of data providing summary and detailed reports which identify performance trends that lead to corrective actions. The challenges of such approach are effective use of the information to realise positive changes, balancing the annual system support and development costs against the business needs, and maximising system performance. (author)

  10. Lessons Learnt of Thai Women Environmental Leaders

    Directory of Open Access Journals (Sweden)

    Sittipong Dilokwanich

    2015-07-01

    Full Text Available During the past few decades, Thai women have learned how to extent their roles from a care taker of children and a household to natural resources and environmental protection and management in local and inter-regional communities. Due to the application of National Economic and Social Development Plans, rapid resource exploitation has brought in natural resource and environmental degradation all over the country threatening communal security. For this reason, there have been a number of emerging environmental leaders who want to correct directions of national development, especially Thai woman environmental leaders who are taking a successful role of environmental guardian in their communities. This research attempts to explore why they took leadership role in environment, how they work so successful as an environmental guardian, and what their next move is. During early 2013 till mid-2014, there are 28 Thai woman leaders who received the award of Thai Environmental Conservation Mother from the Faculty of Environment and Resource Studies, Mahidol University between 2004 and 2012. They were in-depth interviewed and collected data were preceded by content analysis. Their lessons learnt show that most leaders saved their communities' environment and natural resources from the intervention of new development activities. Most of them had their parents as a good role model in environmental management who provide knowledge of morals and environmental ethics as a good basic of leadership while some shared their husband's responsibility in the same matter. Significantly, teamwork is their working style with the assistance of public participation to hold teamwork and collaboration of the community. Almost all leaders had systematic working with talents of patience, gentleness and sensitivity. The working network also broadens their new information and knowledge between practitioners. In the same time, more than half of the leaders can prepare their

  11. Adapting Features from the SIOP Component: Lesson Delivery to English Lessons in a Colombian Public School

    Directory of Open Access Journals (Sweden)

    Rativa Murillo Hollman Alejandro

    2013-04-01

    Full Text Available Despite some school efforts to offer students the best second language learning, English language lessons are often taught with an overuse of the mother tongue. Hence, an action research project was conducted in order to discover how to adapt some features of the Sheltered Instruction Observation Protocol (SIOP component: Lesson delivery, for the teaching of English in sixth grade at a public school in Bogotá, Colombia. Data collection included observation checklists, field notes, surveys and artifacts. The findings demonstrated that the overuse of Spanish–the students’ mother tongue–was reduced when in addition to implementing the lesson delivery component, the teacher developed vocabulary activities. Finally, it was suggested that teachers have SIOP training for teaching content andto focus more on students needs.A pesar de algunos esfuerzos para ofrecer a los estudiantes un mejor aprendizaje de una segunda lengua, a menudo se recurre al uso excesivo de la lengua materna en las clases de inglés. Con el objetivo de hallar la forma de adaptar algunas características del componente del protocolo deobservación SIOP para la instrucción ‘Sheltered’: Desarrollo de clase, para la enseñanza de inglés en grado séptimo, se realiz�� un proyecto de investigación acción en un colegio público en Bogotá, Colombia. En la recolección de datos se emplearon formatos de observación, notas de campo,cuestionarios y evidencias documentales. Los resultados demostraron que el uso excesivo de español –la lengua materna de los estudiantes– se redujo porque además de la implementación del componente Desarrollo de clase, se llevaron a cabo actividades de vocabulario. Con esta investigación se sugiere que los profesores adquieran conocimientos acerca del citado modelo para la enseñanza de contenidos, y que se enfoquen más en las necesidades de los estudiantes.

  12. Summary of Session 1 'Lessons from 2011'

    Energy Technology Data Exchange (ETDEWEB)

    Lamont, M; Bracco, C [European Organization for Nuclear Research, Geneva (Switzerland)

    2012-07-01

    Review of 2011 LHC Run from The Experiments Perspective, M. Ferro-Luzzi (PH-LBD): M. Ferro-Luzzi highlighted the excellent performance of the machine and the experiments in 2011 and the fast and impressive achievements both when operating with protons and Pb ions. In a month the same luminosity as during the full 2010 proton run was delivered, and a factor 16 higher luminosity was produced with Pb ions. The excellent machine performance allowed ATLAS and CMS to make interesting observations in the context of the Higgs’ boson search and LHCb found some evidence of CP violation in time-integrated D0 which could open the way for a new physics. Input from Evian, M. Lamont (BE-OP): M. Lamont presented a summary of what discussed in Evian about lessons learnt during 2011 operation and improvements foreseen for 2012. He underlined that 2011 was a remarkable year with a continuously faster increase in luminosity production and without real show stoppers. The machinewas characterized by operational robustness, a good reproducibility, stability, beam lifetime, optics control and an excellent performance of the Machine Protection system (MPs) and of the injectors. The 2011 Run: Availability Analysis, A. Macpherson (BE-OP): A. Macpherson spoke about machine availability in 2011 and gave some statistics of fills for p-p and Pb-Pb runs. He calculated a machine availability of 76.7% and that 33% of the operation time was spent in stable beam. The Hubner factor, which gives an estimate of the luminosity production duration, was slightly bigger than the expected 0.2 value both for the proton (0.22) and lead ion (0.24) runs. Stable beams lasted in average ∼6 hours but about 50% of the fills were shorter than 4 hours. Injection and Lessons for 2012, C. Bracco (TE-ABT): C. Bracco made a presentation on the performance of the injection system. The injection of 144 bunches became fully operational in 2011 in agreement with what predicted during the last Chamonix workshop. Moreover

  13. PENERAPAN LESSON STUDY UNTUK MENINGKATAN KEMAMPUAN MENGAJAR MAHASISWA CALON GURU FISIKA

    Directory of Open Access Journals (Sweden)

    Rif’ati Dina Handayani

    2015-02-01

    ABSTRAK Lesson study merupakan suatu model pengembangan kemampuan mengajar melalui pengkajian pembelajaran secara kolaboratif dan berkelanjutan. Lesson study dilaksanakan dalam tiga tahapan, yaitu plan, do, see yang dilaksanakan secara terstruktur, bersiklus dan berkelanjutan. Dalam penelitian ini subjek dari pelaksanaan lesson study adalah empat orang  mahasiswa calon guru fisika yang sedang melaksanakan PPL di salah satu SMP Negeri di Bondowoso. Hasil penelitian menunjukkan bahwa penerapan lesson study dapat meningkatkan kemampuan mengajar mahasiswa calon guru fisika dari kriteria kurang baik menjadi kriteria sangat baik. Kata kunci: Calon guru fisika, Lesson Study, Kemampuan Mengajar

  14. A Text Mining Approach for Extracting Lessons Learned from Project Documentation: An Illustrative Case Study

    Directory of Open Access Journals (Sweden)

    Benjamin Matthies

    2017-12-01

    Full Text Available Lessons learned are important building blocks for continuous learning in project-based organisations. Nonetheless, the practical reality is that lessons learned are often not consistently reused for organisational learning. Two problems are commonly described in this context: the information overload and the lack of procedures and methods for the assessment and implementation of lessons learned. This paper addresses these problems, and appropriate solutions are combined in a systematic lesson learned process. Latent Dirichlet Allocation is presented to solve the first problem. Regarding the second problem, established risk management methods are adapted. The entire lessons learned process will be demonstrated in a practical case study

  15. Lessons offered, lessons learned: reflections on how doing family therapy can affect therapists.

    Science.gov (United States)

    Heatherington, Laurie; Friedlander, Myrna L; Diamond, Gary M

    2014-08-01

    Only in working conjointly with couples and families do therapists literally witness clients struggling to improve their most intimate relationships. In writing this article, we realized that, in true systemic fashion, not only have many of our clients benefited from working with us, but also we have learned some invaluable lessons from them. Indeed, practicing couple and family therapy gives therapists many opportunities to learn about themselves, especially when it is done thoughtfully. In this article, we reflect on myriad ways in which couples and family therapy has affected each of us personally-as individuals, as partners, as parents, as adult children in our families of origin, and as educators. © 2014 Wiley Periodicals, Inc.

  16. Treating Social Anxiety in Adolescents: Ten Group Therapy Lesson Plans

    Science.gov (United States)

    Mazur-Elmer, Alison; McBride, Dawn

    2009-01-01

    This project provides a comprehensive overview of the research literature on social anxiety disorder (SAD) in adolescents and concludes by offering a set of 10 group therapy lesson plans for SAD that therapists can use in their practice. The overview includes a description of social anxiety disorder and highlights various theories of anxiety. The…

  17. Finance, growth, and stability : Lessons from the crisis

    NARCIS (Netherlands)

    Beck, T.H.L.

    This article introduces a special issue on lessons from the recent crisis on finance, growth, and stability. The papers in the special issue discuss (i) the benefits and risks of financial innovation and regulatory responses to these risks, (ii) the effect of finance and globalization on the real

  18. Software Patching Lessons Learned - Video Text Version | Energy Systems

    Science.gov (United States)

    just looking at a clock and doing it on a rhythmic basis or even just outside of the standard, you analysis accuracy is difficult. And this is essentially the quality of what you're finding and how you that process. All right. Lesson number four. Asset analysis is complicated. This is essentially knowing

  19. The Education and Lifestyle of the Chinese Literati. Lesson Plan.

    Science.gov (United States)

    Smithsonian Institution, Washington, DC. Arthur M. Sackler Gallery.

    This teaching package describes the education and lifestyle of the Chinese literati, popular from the Ming to the Qing dynasties (1368-1911). It consists of four lesson plans and a teacher's guide to a slide set. The latter illustrates painting formats popular during the late Ming period (1573-1644), hanging scrolls, handscrolls, the album leaf,…

  20. Egyptian Symbols and Figures. Hieroglyphs [and] Scroll Paintings. [Lesson Plan].

    Science.gov (United States)

    2002

    This lesson introduces students to the writing, art, and religious beliefs of ancient Egypt through hieroglyphs, one of the oldest writing systems in the world, and through tomb paintings. Hieroglyphs consist of pictures of familiar objects that represent sounds and were used in ancient Egypt from about 3100 BC to 400 CE. In the first part of the…