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Sample records for les melanomes cutanes

  1. Staging of cutaneous malignant melanoma by CT; CT-Staging kutaner maligner Melanome

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    Hoffend, J. [Klinikum der Stadt Ludwigshafen gGmbH, Zentralinstitut fuer diagnostische und interventionelle Radiologie, Ludwigshafen (Germany)

    2015-01-30

    Malignant melanomas are a challenge in radiological imaging diagnostics as they may metastasize into every organ and tissue. Cross-sectional imaging, in particular positron emission tomography computed tomography (PET/CT) and whole body magnetic resonance imaging (MRI), are considered the standards in the staging of melanomas. Because of its excellent availability CT, however, remains a widely employed staging modality. Familiarity with the manifold CT morphology of metastasized melanomas as it is described here is essential when interpreting dedicated CT and in addition useful when interpreting PET/CT results. In individual cases CT can assist in the detection of transient metastases. In the detection of locoregional lymph node metastases CT has a median sensitivity and specificity in meta-analyses of at best 61 % and 97 %, respectively, which is inferior to the performance of ultrasound (96 % and 99 %, respectively). According to meta-analyses, in the assessment of systemic tumor spread CT can detect the majority of metastases with a sensitivity and specificity of 51-63 % and 69-78 %, respectively, which is inferior to MRI and PET/CT. Therefore, if an exact staging is required for critical management decisions, MRI or PET/CT should be employed whenever possible. (orig.) [German] Maligne Melanome koennen in praktisch jedes Organ und Gewebe metastasieren und stellen daher eine Herausforderung fuer die radiologische Diagnostik dar. Schnittbildverfahren, bevorzugt PET/CT und MRT, werden heute als Standard in der Ausbreitungsdiagnostik von Melanomen angesehen. Wegen ihrer ubiquitaeren Verfuegbarkeit bleibt jedoch die CT ein vielfach genutztes Staginginstrument. Die Kenntnis der vielfaeltigen CT-Morphologie von Melanommetastasen, wie sie in diesem Beitrag beschrieben wird, ist ueber die dedizierte CT hinaus uebertragbar auf die von der aktuellen Leitlinie bevorzugte Bildgebung mit der PET/CT. Im Einzelfall kann die CT hilfreich bei der Detektion von In

  2. Unusual subcutaneous metastatic spreading pattern of malignant melanoma; Ungewoehnliches subkutanes Metastasierungsmuster eines malignen Melanoms

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    Dorenbeck, U.; Feuerbach, S. [Inst. fuer Roentgendiagnostik, Universitaetsklinik Regensburg (Germany); Abels, C. [Klinik und Poliklinik fuer Dermatologie, Universitaetsklink Regensburg (Germany)

    1999-11-01

    The contribution is a case report on massive, subcutaneous metastatic spreading of a malignant melanoma. Ten months after excision of a malignant melanoma, the truncus of the 51 year-old male patient showed multiple hematomas sized from 1-3 cm{sup 2}, located above cutaneous/subcutaneous lumps of which some were painful and non-displaceable. The examinations for detection of meatastes as well had shon an unusual picture in that there was no spreading to the lungs. CT scans revealed subcutaneous filiae to an extent unseen before. This final diagnosis is all the more of high interest as an initial diagnosis falsely interpreted this metastatic spreading pattern to be a hemorrhagic diathesis. Together with the unusual non-spreading to the lungs, this case of subcutaneous formation of metastases indicates that in staging examinations of melanoma patients, such rare patterns of metastatic spreading should be taken into account. (orig./CB) [Deutsch] Es wird ueber den Fall einer massiven subkutanen Metastasierung eines malignen Melanoms berichtet. Zehn Monate nach der Exzision eines malignen Melanoms zeigten sich bei dem 51jaehrigen maennlichen Patienten am Stamm multiple 1-3 cm{sup 2} grosse flaechige Haematome ueber kutanen/subkutanen, teils schmerzhaften und nicht verschieblichen Knoten. Auffallend war, dass auch im Verlauf keine intrapulmonalen Absiedlungen gefunden wurden. Interessant ist die Darstellung der subkutanen Filiae im Computertomogramm, die wir so massiv noch nicht gesehen haben. Da die Metastasierung zuerst als haemorrhagische Diathese fehldiagnostiziert wurde, scheint die Diagnose einer subkutanen Aussaat eines malignen Melanoms um so interessanter. Der zusaetzlich zur subkutanen Metastasierung fehlende Lungenbefall zeigt, dass bei Staginguntersuchungen von Melanompatienten ein Metastasierungstyp vorliegen kann, welcher erheblich von gaengigen Metastasierungsmodellen abweichen kann. (orig.)

  3. Les manifestations cutanées chez les patients hémodialysés chroniques dans un pays en voie de développement

    Science.gov (United States)

    Coulibaly, Gérard; Korsaga-Somé, Nina; Fomena, Dorisse Fernade Yongué; Nagalo, Yacouba; Karambiri, Adama Roger; Bassolet, Alban; Kafando, Hyacinthe; Traoré, Adama; Lengani, Adama

    2016-01-01

    Le but de cette étude était deconnaître les affections cutanées les plus fréquentes chez les patients hémodialysés chroniques du Centre Hospitalier Universitaire Yalgado Ouédraogo (CHU-YO) de Ouagadougou. L’étude, de type transversal descriptif, menée du 15 Septembre au 31 Décembre 2014, s'estdéroulée au CHU-YO. Elle concernait les patients qui avaient au moins trois mois d'ancienneté en hémodialyse chronique. La fréquence des séances d'hémodialyse était d'une tous les cinq jours. Le seuil de signification des tests statistiques était défini pour une probabilité p ≤ 0,05. Quatre-vingt-quinze patients (61,1% d'hommes et 38,9% de femmes), de moyenne d’âge 42,1 ans participaient à l’étude. La durée moyenne en hémodialyse était de 31,9 mois. Le taux de réalisation des analyses biologiques variait de 7,4 à 85,3%. Quatre-vingt patients (85,3%) avaient au moins une manifestation cutanée. La xérose cutanée (67,4%), le prurit (45,3%), et l'hyperpigmentation (23,2%) étaient les plus fréquentes des manifestations cutanées pouvant être spécifiques de l'hémodialyse. L'hypomélanose en gouttes (11,6%), le prurigo (11,6%) et la folliculite (8,4%) étaient les principales manifestations cutanées non spécifiques. L'atteinte cutanée était fréquente mais ne semblait pas liée à l'ancienneté en hémodialyse. Les mauvaises conditions d'hémodialyse et l'environnement sec et chaud à Ouagadougou, ont pu favoriser ces atteintes, en particulier la xérose et le prurit. Une meilleure subvention des soins de santé contribuerait à réduire la prévalence des maladies cutanées et à améliorer la qualité de vie de nos patients hémodialysés chroniques. PMID:27642449

  4. Klinische Ergebnisse nach stereotaktischer Präzisionsbestrahlung großer uvealer Melanome mit dem Gamma-Knife

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    Schonenbach, Sabine

    2006-01-01

    Von Juni 1997 bis April 2001 wurden 97 Patienten, die an einem unilateralen uvealen Melanom litten, mit dem Gamma-Knife radiochirurgisch behandelt. Die Melanome aller 97 Patienten waren aufgrund der Lokalisation oder der Größe für eine Therapie mit Ruthenium-Applikatoren nicht geeignet. Alle 97 Patienten, die sich der Therapie mit dem Gamma-Knife unterzogen, wurden in eine engmaschige Nachsorge aufgenommen. Bei der Nachsorge wurden in regelmäßigen Abständen klinische, echographische und n...

  5. Cutaneous neonatal lupus with cutis marmorata telangiectatica congenita-like lesions Lúpus cutâneo neonatal com lesões semelhantes à cutis marmorata telangiectatica congênita

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    Flávia Trevisan

    2013-06-01

    Full Text Available Neonatal lupus is a rare disease caused by the transplacental transfer of maternal autoantibodies to the foetus, characterized by transient clinical manifestations such as cutaneous, haematological, and hepatobiliary events or permanent such as congenital heart block. The typical cutaneous manifestations include erythematous, scaly, annular or arched lesions on the face, with slight central atrophy and photosensitivy, clinically and histologically similar to subacute cutaneous lupus. However, in some cases, the lesions may resemble those in cutis marmorata telangiectatica congenita, although this phenomenon is rare and only eight such cases have been reported to date. We report a case of cutaneous neonatal lupus with atypical lesions on the limbs, which had a reddish-purple marbled appearance, resembling the lesions in cutis marmorata telangiectatica congenita.Lúpus neonatal é uma doença rara causada pela transferência de auto-anticorpos maternos para o feto, caracterizada por manifestações clínicas transitórias como cutâneas, hematológicas e hepatobiliares, ou permanentes como o bloqueio cardíaco congênito. As manifestações cutâneas típicas incluem lesões fotossensíveis descamativas, anulares ou arqueadas na face, com discreta atrofia central, clinica e histopatologicamente similares ao lúpus cutâneo subagudo. Entretanto, em alguns casos, as lesões podem lembrar aquelas da cutis marmorata telangiectatica congênita, mas esse fenômeno é raro e somente oito casos foram reportados até hoje. Nós relatamos aqui um caso de lúpus cutâneo neonatal com lesões atípicas nos membros de cor vermelho-purpúricas e aparência marmórea, semelhantes às lesões da cutis marmorata telangiectatica congênita.

  6. Lymphatic mapping and sentinel node biopsy in early stage melanoma: study of the first 100 cases in Institut Gustave Roussy; Lymphoscintigraphie et biopsie du ganglion sentinelle dans les melanomes cutanes primitifs: analyse des 100 premiers cas a l'Institut Gustave Roussy

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    Buffard, V.; Duvillard, P. [Institut Gustave Roussy, Service de Dermatologie, 94 - Villejuif (France); Mamelle, G. [Institut Gustave Roussy, Service de Chirurgie Cervico-faciale, 94 - Villejuif (France); Lumbroso, J.; Ricard, M. [Institut Gustave Roussy, Service de Medecine Nucleaire et de Physique Medicale, 94 - Villejuif (France); Kolb, F.; Sleilati, F. [Institut Gustave Roussy, Service de Chirurgie Plastique, 94 - Villejuif (France); Spatz, A. [Institut Gustave Roussy, Service d' Histopathologie, 94 - Villejuif (France)

    2005-01-15

    Introduction: We report the data of the first 100 patients who underwent sentinel lymph node biopsy (SLND) in our institution using lymphoscintigraphy only. Patients and methods: From 1998 to 2000, 100 consecutive patients (53 men and 47 women) with stage I or II melanoma (mean Breslow: 3.11 mm) underwent a SLND. Localisation of the sentinel node was performed by preoperative lymphoscintigraphy and hand held gamma probe detection. The sentinel node was examined by routine histology and immunohistochemistry for PS100 and HMB-45. If the sentinel node contained tumor cells, a complete lymphadenectomy was performed. Results: Lymphoscintigraphy was performed for 97 patients. The SLN was identified in 97% of cases (94/97) and excised in 95% of cases (92/97). The rate of SLN metastasis was 19/92 patients (21%), correlated with Breslow index (< 1.5 mm: 5%, 1.5-4 mm: 15%, > 4 mm: 46%). A mean number of 1.81 lymph node per patient was analysed. The mean follow-up was 26 months with a relapse in 14 patients, 5 of them having a metastatic sentinel node. Three patients had a recurrence at the site of the SLND although they had initially a negative sentinel node. Conclusion: The identification and metastatic rates of sentinel nodes are similar to those of the literature. More studies are needed to determine whether lymphoscintigraphy alone is efficient for successful SLND in melanoma. (author)

  7. Local recurrent and metastatic malignant melanoma. Long-term results and prognostic factors following percutaneous radiotherapy; Lokal rezidiviertes und metastasiertes malignes Melanom. Langzeitergebnisse und Prognosefaktoren nach perkutaner Radiotherapie

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    Seegenschmiedt, M.H. [Erlangen-Nuernberg Univ. (Germany). Klinik fuer Strahlentherapie; Alfried-Krupp-von-Bohlen-und-Halbach-Krankenhaus, Essen (Germany). Klinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Keilholz, L.; Pieritz, A.; Urban, A.; Sauer, R. [Erlangen-Nuernberg Univ. (Germany). Klinik fuer Strahlentherapie; Altendorf-Hofmann, A.; Hohenberger, W. [Erlangen-Nuernberg Univ. (Germany). Klinik fuer Chirurgie; Schell, H. [Erlangen-Nuernberg Univ. (Germany). Klinik fuer Dermatologie

    1999-09-01

    Purpose: Radiotherapy (RT) is used as last resort for patients with advanced cutaneous malignant melanoma (MM). Herein our 20-year clinical experience is presented analyzing different endpoints and prognostic factors in patients with locally advanced, recurrent or metastatic MM. Patients and Methods: From 1977 to 1995, 2,917 consecutive patients were entered in the MM registry of our university hospital. RT was indicated in 121 patients (56 females, 65 males) for palliation in locally advanced recurrent and metastatic MM stages UICC IIB to IV. At the time of RT initiation, 11 patients had primary or recurrent lesions which were either not eligible for surgery or had residual disease (R2) after resection of a primary or recurrent MM lesion (UICC IIB); 57 patients had lymph node (n=33) or in-transit metastases (n=24) (UICC III), and 53 had distant organ metastases (7 M1a, 46 M1b) (UICC IV). The time from first diagnosis to on-study RT averaged overall 19 months (median: 18; range: 3 to 186 months). In 77 patients conventional RT and in 44 patients hypofractionated RT was applied with 2 to 6 Gy fractions up to a mean total RT dose of 45 (median: 48; range: 20 to 66) Gy. Results: At 3 months follow-up, complete response (CR) was achieved in 7 (64%), overall response (CR+PR) in all (100%) UICC IIB patients, in 25 (44%) and 44 (77%) of 57 UICC III patients, and in 9 (17%) and 26 (49%) of 53 UICC IV patients. Tumor progression during RT occurred in 25 (21%) patients. Patients with CR survived longer (median: 40 months) than those without CR (median 10 months) (p<0.01). At the time of evaluation and last FU (December 31, 1996), 26 patients were still alive: 6 (55%) stage UICC IIB, 17 (30%) stage UICC III, and 3 (6%) stage UICC IV patients (p<0.01). Univariate analysis revealed following prognostic factors for CR and long-term survival: UICC stage (p<0.001), primary location in the head and neck, total RT dose >40 Gy (all p<0.05), while age, gender and primary histological

  8. Terapia tópica com pimecrolimus em lesão cutânea refratária de lúpus eritematoso sistêmico Topical therapy with pimecrolimus in refractory cutaneous lesion of systemic lupus erythematosus

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    Leandro Vasconcellos Rangel

    2006-06-01

    Full Text Available O rash do lúpus eritematoso sistêmico (LES é usualmente tratado com corticosteróides tópicos, porém seu uso prolongado causa efeitos adversos cutâneos. Pimecrolimus é um protótipo da classe de agentes imunosupressores tópicos com grande potencial para o tratamento de doenças inflamatórias cutâneas. Terapia tópica com pimecrolimus foi aplicada em lesões cutâneas de face em um caso de LES refratária a esteróides sistêmico e tópico. Houve uma marcante regressão das lesões de pele, após terapia com pimecrolimus. Este tratamento foi bem tolerado, sem efeitos colaterais nesta paciente. Pimecrolimus tópico parece ser uma nova ferramenta para o manejo de lesões cutâneas refratárias em LES.The rash of systemic lupus erythematosus (SLE is usually treated with topical corticosteroids, but prolonged use causes adverse cutaneous side-effects. Pimecrolimus is a prototype of a class of topical immunosuppressive agents with great potential for the treatment of inflammatory skin diseases. Topical pimecrolimus therapy was applied to facial skin lesions in one case of SLE refractory to topical and systemic steroids. There was a marked regression of the skin lesions after pimecrolimus therapy. This treatment was well tolerated without side effects in this patient. Topical pimecrolimus seems to be a new tool for the management of refractory skin lesions in lupus erythematosus.

  9. Treatment side effects and follow-up of malignant melanoma; Therapienebenwirkungen und Nachsorge bei malignem Melanom

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    Stahl, T. [Klinikum der Stadt Ludwigshafen gGmbH, Zentralinstitut fuer diagnostische und interventionelle Radiologie, Ludwigshafen (Germany); Loquai, C. [Universitaetsmedizin der Johannes-Gutenberg Universitaet Mainz, Hautklinik und Poliklinik, Mainz (Germany)

    2015-01-30

    Side effects in the therapy of malignant melanoma are primarily of importance for radiologists in advanced tumor stages. The available treatment options and their respective side effect profiles have undergone a profound change in recent years after the introduction of modern oncological therapies (e.g. immunotherapy and targeted therapy) with an increasing focus on individual tumor biology and differ significantly from those of classical chemotherapy. The immunotherapeutic agents, in particular ipilimumab, take on a special position because of their specific immune-mediated mechanisms of action and the associated side effects, so-called immune-related adverse events (irAE). The majority of the treatment effects are manifested on the skin (> 50 %) and are generally not detectable by diagnostic radiology. Only a comparatively small proportion of treatment side effects is detectable with diagnostic imaging (15-20 %) but as in the example of therapy-induced colitis with ipilimumab, may be rapidly fatal. In addition to colitis (10-20 %) further therapy side effects apparent in diagnostic imaging are hypophysitis (1.8-17 %), thyroiditis (0.8 %), myositis (1.7 %), fasciitis and sarcoid-like lymph node alterations (6.8 %). To detect radiologically detectable side effects early on and to delineate them especially from tumor progression and (opportunistic) infections, detailed knowledge of the therapeutic methods for melanoma, the mechanisms of action and in particular the sometimes very specific side effects is imperative for radiologists. (orig.) [German] Nebenwirkungen der Therapie des malignen Melanoms sind fuer den Radiologen primaer in fortgeschrittenen Tumorstadien von Bedeutung. Die zur Verfuegung stehenden Therapieoptionen und ihre jeweiligen Nebenwirkungsprofile haben sich in den letzten Jahren nach Einfuehrung moderner onkologischer Therapieoptionen, die sich zunehmend an der individuellen Tumorbiologie orientieren (zielgerichtete Therapie, Immuntherapie), einem

  10. The sentinel-lymphonodectomy in malignant melanoma; Die Sentinel-Lymphonodektomie beim malignen Melanom

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    Bachter, D.; Starz, H.; Volkmar, C.; Balda, B.R. [Zentralklinikum Augsburg (Germany). Klinik fuer Dermatologie und Allergologie; Vogt, H. [Zentralklinikum Augsburg (Germany). Klinik fuer Nuklearmedizin; Buechels, H. [Zentralklinikum Augsburg (Germany). II. Chirurgische Klinik

    1999-10-01

    The concept of the removal of the sentinel lymph node (SLN) opens a new era in the primary therapy of malignant melanoma. This procedure allows an exact staging of the regional lymph nodes and selects only those patients with metastases for an early regional lymphadenectomy. Lymphoscintigraphy by Technetium-labeled human albumin and the intraoperative localization of the SLN guided by a gammaprobe combined with blue dye injections for the persecution of the lymph ways delivers optimal results. The histological proof of the often tiny micrometastases succeeds best in doing serial sectioning with confirmatory immunohistochemistry. We recommend the sentinel lymphonodectomy (SLNE) in all new diagnosed melanomas in clinical stages Ib to IIIa (DDG-classification). When finding metastases in the SLN, a radical lymphadenectomy should follow. Although a survival benefit has not yet shown, the SLNE allows to select patients for further therapies in very early stage of the disease. (orig.) [German] Das Konzept zur operativen Entfernung des Sentinel-Lymphknotens (SLN) leitet eine neue Aera in der Primaertherapie des malignen Melanoms ein. Dieses Verfahren erlaubt ein exaktes Staging der regionaeren Lymphknoten und selektioniert somit nur diese Patienten fuer eine fruehe regionaere Lymphknotendissektion, bei denen Tumorbefall nachgewiesen werden konnte. Die Darstellung des SLN gelingt am besten mit Hilfe von Technetium-markiertem Humanalbumin zur intraoperativen Lokalisation mittels einer Szintillationsmesssonde in Kombination mit einer Patentblaumarkierung des Lymphabflusses. Die histologische Aufarbeitung der Lymphknoten in Schnittserien mit entsprechenden immunhistochemischen Faerbungen erleichtert den mikroskopischen Nachweis der oft sehr kleinen Mikrometastasen. Wir halten die Sentinel-Lymphonodektomie (SLNE) bei neu diagnostizierten Melanomen in den klinischen Stadien Ib-IIIa fuer dringend indiziert. Bei Nachweis von Melanommetastasen im SLN ist derzeit allerdings noch

  11. Gebrauch von Komplementärmedizin bei Patienten mit metastasierendem Melanom unter Therapie mit Ipilimumab innerhalb einer klinischen Studie.

    Science.gov (United States)

    Huebner, Jutta; Mohr, Peter; Simon, Jan-Christoph; Fluck, Michael; Berking, Carola; Zimmer, Lisa; Loquai, Carmen

    2016-05-01

    In Deutschland wenden 40-90 % aller Krebspatienten Methoden der komplementären and alternativen Medizin (KAM) an. Bis dato gibt es kein Datenmaterial zum Einsatz der KAM bei Melanompatienten. Das Ziel unserer Studie war es, Daten über den Gebrauch, die Informationsquellen und Ziele von Patienten mit metastasierendem Melanom zu erfassen. Einhundertsechsundfünfzig Patienten aus 25 Studienzentren nahmen an der DecOG-MM-PAL Multibasket Studie teil. Die beteiligten Personen wurden auch gebeten, an einer Nebenstudie teilzunehmen, die ihren Gebrauch von KAM erfassen sollte. Dazu wurde während der Behandlung ein standardisierter Fragebogen zu genau festgelegten Zeitpunkten ausgeteilt. Insgesamt gingen 55 Fragebögen von 32 (21 %) Melanompatienten ein. Von diesen gaben 17 (53 %) ein Interesse an KAM an, und sieben (22 %) machten von KAM Gebrauch. Die Hauptinformationsquellen (31 %) waren Familienmitglieder und Freunde, gefolgt von Ärzten (19 %). Die Hauptgründe für die Anwendung von KAM waren die Stärkung des Immunsystems (41 %) und des Körpers (34 %). Nahrungsergänzungsmittel (Vitamine und Spurenelemente) wurden am häufigsten angewendet (28 %). Eine relativ hohe Anzahl an Patienten mit metastasierendem Melanom machte trotz Teilnahme an einer klinischen Studie von KAM Gebrauch. Wechselwirkungen könnten durch biologisch basierte KAM auftreten, und hier besonders bei immunmodulierenden KAM- Strategien. Um Risiken zu vermeiden, sollte die Kommunikation zwischen den Ärzten und den Patienten verbessert werden. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  12. les et modes d'action de l'annexine A1 dans la dissémination du mélanome cutané

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    Boudhraa, Zied

    2013-01-01

    Cutaneous melanoma is the most aggressive skin cancer. Treatment options are limited and inefficient when melanoma has metastasized. In order to identify new markers of melanoma dissemination, protein profiles of two genetically similar murine melanoma cell lines have been compared. Both B16F10 and B16Bl6 cells induced primary tumours after subcutaneous graft, however, only B16Bl6 melanomas develop metastases. Among proteins differentially expressed, annexin A1 (ANXA1) is overexpressed in the...

  13. Mesenchymal stem cells favour healing of the cutaneous radiation syndrome; Les cellules souches mesenchymateuses favorisent la cicatrisation des lesions cutanees radio induites

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    Francois, S.; Mouiseddine, M.; Mathieu, N.; Semont, A.; Monti, P.; Dudoignon, N.; Sache, A.; Boutarfa, A.; Thierry, D.; Voisin, P.; Gourmelon, P.; Chapel, A. [IRSN, Dir. de radioprotection de l' Homme, 92 - Fontenay-aux-Roses (France)

    2006-10-15

    It has been suggested that human Mesenchymal Stem Cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC in order to limit radiation-induced skin lesions. Immuno-deficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/mn) using a {sup 60} Co source in order to induce a severe skin lesion. Cultured bone marrow hMSC were delivered intravenously to the mice. The irradiated skin samples were studied for the presence of the human cells, the severity of the lesions and the healing process. Macroscopic analysis and histology results showed that the lesions were evolving to a less severe degree of radiation dermatitis following hMSC transplant when compared to irradiated non-transplanted controls. Clinical scores for the studied skin parameters of treated mice were significantly improved. A faster healing was observed when compared to untreated mouse. Immuno-histology and Polymerase Chain reaction (PCR) analysis provided evidence that the human cells were found in the irradiated area. These results suggest a possible use of hMSC for the treatment of the early phase of the cutaneous radiation syndrome. A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy. (authors)

  14. Cerebral MR imaging of malignant melanoma; Zerebrale MR-Bildgebung beim malignen Melanom

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    Breckwoldt, M.; Bendszus, M. [Universitaetsklinikum Heidelberg, Abteilung Neuroradiologie, Neurologische Klinik, Heidelberg (Germany)

    2015-01-16

    even in asymptomatic patients. Stage IV requires quarterly MRI examinations. Melanotic and amelanotic metastases show different MRI characteristics. The differentiation between metastasis and microbleeding can be impossible and might require a follow-up scan. Susceptibility-weighted imaging increases the sensitivity of metastases detection but lacks specificity. It can help to differentiate between different metastatic entities. (orig.) [German] Das maligne Melanom (MM) ist nach dem Bronchial- und Mammakarzinom die dritthaeufigste Tumorentitaet, die in das ZNS metastasiert. Haeufig geschieht dies frueh im Krankheitsverlauf, was fuer die Prognose entscheidend ist. Zehn bis 40 % aller Patienten sterben an einer intrakraniellen Metastasierung, wobei die Inzidenz von Hirnmetastasen noch deutlich hoeher liegt (50-75 %). Praedilektionsstelle ist das subkortikale Marklager. Das Signalverhalten von Melanommetastasen kann sehr unterschiedlich sein und sich im Krankheitsverlauf, abhaengig von Melaningehalt, Akkumulation paramagnetischer Ionen und Einblutungen, aendern. Die neuen spezifischen Therapien (Immuntherapien und Kinaseinhibitoren) stellen auch fuer die Bildgebung eine Herausforderung dar, weil bislang nicht ausreichend geklaert ist, inwieweit diese das Signalverhalten von Metastasen in der MR-Bildgebung aendern. Zudem koennen unter den neuen Therapien immunassoziierte Pathologien (Hypophysitis bei ca. 5 % der Patienten unter Ipilimumab-Therapie) und granulomatoese Erkrankungen (Neurosarkoidose) auftreten. In der CT stellen sich Melanommetastasen haeufig nativ hyperdens dar. In der MRT sind T2w-Fluid-attenuated-inversion-recovery(FLAIR)-, native T1w- sowie T1w-Sequenzen nach Kontrastmittelgabe obligat. Mehrere Schnittebenen sollten akquiriert werden. Die suszeptibilitaetsgewichtete Bildgebung (SWI) ist eine neue sensitive Methode zur Detektion von Melanommetastasen bei jedoch eingeschraenkter Spezifitaet. Etwa 66 % der Melanommetastasen zeigen ausgepraegte intratumorale

  15. Late effects on skin and subcutaneous tissues after breast irradiation; Effets tardifs de la radiotherapie mammaire sur la peau et les tissus sous-cutanes

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    Dubray, B. [Institut Curie, 75 - Paris (France); Delanian, S. [Hopital Saint-Louis, 75 - Paris (France); Lefaix, J.L. [CEA Fontenay-aux-Roses, 92 (France). Dept. de Radiobiologie et de Radiopathologie

    1997-12-01

    Late damages to the skin and subcutaneous tissues are almost inescapable because of the high skin doses required in the irradiation of breast tumours. While the clinical and histological descriptions date back to the first decades of the therapeutic use of ionising radiation the recent advances in cellular and molecular biology have significantly contributed to the increased understanding of late skin injury mechanisms. In particular, sub-cutaneous fibrosis appears to be the partly reversible results of a continuous and self-maintained local process, possibly sensitive to therapeutic intervention. A second very active research avenue is the development of biologic assays potentially able to predict the probability of increased normal tissue injury after irradiation in individual patients. Such a test would allow the adaptation of the treatment modalities to the radiobiological behaviour of normal tissues. To date, these expectations have not been met. The quality of the irradiation and its modalities (total dose, fractionation, inter fraction interval) remain the main ways to achieve an optimal functional and cosmetic outcome. (authors)

  16. Cutaneous amebiasis.

    Science.gov (United States)

    Rimsza, M E; Berg, R A

    1983-04-01

    An infant with cutaneous amebiasis of the vulva and amebic liver abscess is described. Epidemiologic investigations and serologic studies were crucial in establishing the diagnosis. The vulvar amebic ulcers responded dramatically to metronidazole therapy. Cutaneous amebiasis is a rare complication of Entamoeba histolytica infection which should be considered in the differential diagnosis of perineovulvar or penile ulcers. Cutaneous amebiasis may also occur on the abdominal wall surrounding a draining hepatic abscess, colostomy site, or laparotomy incision.

  17. Cutaneous loxoscelism

    Directory of Open Access Journals (Sweden)

    Purohit S

    1995-01-01

    Full Text Available A case of spider bitea presenting as cutaneous loxoscelism is reported. The clinical features and management of spider bite are highlighted and the relevant literature has been reviewed

  18. Cutaneous zygomycosis.

    Science.gov (United States)

    Bonifaz, Alexandro; Vázquez-González, Denisse; Tirado-Sánchez, Andrés; Ponce-Olivera, Rosa María

    2012-01-01

    Cutaneous zygomycosis is a fungal infection caused by zygomycetes that affects the skin. It occurs in uncontrolled diabetic patients and immunosuppressed individuals. It has 2 clinical forms: primary cutaneous zygomycosis and secondary cutaneous zygomycosis. The first is characterized by necrotic lesions and the fungus is usually inoculated by trauma. If diagnosed early, it generally has a good prognosis. Secondary zygomycosis is usually a complication and extension of the rhinocerebral variety that starts as a palpebral fistula and progresses to a necrotic lesion with a poor prognosis. The diagnosis is made by identification of the fungus by direct KOH examination, culture, and biopsy. Treatment for the primary disease is surgical debridement plus amphotericin B. The secondary type is treated with amphotericin B and/or posaconazole.

  19. Cutaneous sarcoidosis.

    Science.gov (United States)

    Wilson, N J; King, C M

    1998-11-01

    Sarcoidosis is a multi-organ granulomatous disorder of unknown cause. Skin sarcoidosis occurs in about 25% of patients with systemic disease and may also arise in isolation. A wide range of clinical presentations of cutaneous sarcoidosis is recognised. The diagnosis rests on the presence of non-caseating granulomas on skin biopsy and the exclusion of other granulomatous skin disease. The treatment and overall prognosis of cutaneous sarcoidosis is primarily dependent on the degree of systemic involvement. In patients with aggressive disease limited to the skin immunosuppressive therapy may be indicated.

  20. Sentinel node detection by preoperative lymphoscintigraphy and intraoperative gamma-probe guidance in melanoma; Nachweis des Sentinel-Lymphknotens mittels praeoperativer Lymphszintigraphie und intraoperativer Gammasondenmessung bei malignen Melanom

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, H.; Wengenmair, H.; Dorn, R.; Heidenreich, P. [Zentralklinikum Augsburg (Germany). Klinik fuer Nuklearmedizin; Bachter, D. [Zentralklinikum Augsburg (Germany). Klinik fuer Dermatologie und Allergologie; Buechels, H.K. [Zentralklinikum Augsburg (Germany). Klinik fuer Allgemein- und Visceralchirurgie

    1999-08-01

    Aim: The purpose of this work was to prove the clinical significance of nuclear medical procedures in pre-and intraoperative detection of the SLN. Methods: In the past 4 years, we did preoperative lymphoscintigraphy in 214 patients (pts.). Intraoperative localisation of the SLN with a handheld gamma probe followed in 150 pts. Results: In 214 pts. 247 lymphatic draining regions were found by preoperative scintigraphy. In 3 pts. with melanoma of the cheek no lymphatics/lymphe nodes could be detected. 14 pts. showed interval lymph nodes. In 150 pts. gamma probe guided SLNE was done. In 2 pts. with supraclavicular primary tumor 4 SLN had been defined by preoperative scintigraphy but only 2 could be found intraoperatively. In all other cases (98.7%) the sentinel node was detected correctly by the gamma probe and then removed. In 19 of 150 pts. (12.7%) metastases were detected in the pathologic specimen. The incidence of lymph node metastases showed a continuous increase from 0% at tumor stage pT1 to 44% at stage pT4. Conclusion: SLNE is an accurate method to determine nodal involvement in melanoma and minimizes operative invasiveness in melanoma surgery. (orig.) [Deutsch] Ziel der vorliegenden Arbeit ist die Ueberpruefung der Wertigkeit nuklearmedizinischer Verfahren in der prae- und intraoperativen Diagnostik des Sentinel-Lymphknotens (SLN). Methoden: Bei 214 Patienten fuehrten wir waehrend der vergangenen vier Jahre die praeoperative Lymphszintigraphie und bei 150 Patienten die intraoperative Gammasondenmessung zur Lokalisationsdiagnostik des SLN durch. Ergebnisse: Es fanden sich bei 214 Patienten 247 Abflussgebiete. Bei drei Patienten konnte kein Lymphabfluss nachgewiesen werden. Es handelte sich um Melanome der Wange, zwei dieser Patienten waren voroperiert. 14 Patienten zeigten Intervall-Lymphknoten. Bei 150 Patienten erfolgte eine operative Entfernung des SLN (Sentinel-Lymphonodektomie, SLNE) mit intraoperativer Gammasondenmessung. Bei zwei Patienten mit

  1. Sentinel node detection by preoperative lymphoscintigraphy and intraoperative gamma-probe guidance in melanoma; Nachweis des Sentinel-Lymphknotens mittels praeoperativer Lymphszintigraphie und intraoperativer Gammasondenmessung bei malignen Melanom

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, H.; Wengenmair, H.; Dorn, R.; Heidenreich, P. [Zentralklinikum Augsburg (Germany). Klinik fuer Nuklearmedizin; Bachter, D. [Zentralklinikum Augsburg (Germany). Klinik fuer Dermatologie und Allergologie; Buechels, H.K. [Zentralklinikum Augsburg (Germany). Klinik fuer Allgemein- und Visceralchirurgie

    1999-08-01

    Aim: The purpose of this work was to prove the clinical significance of nuclear medical procedures in pre-and intraoperative detection of the SLN. Methods: In the past 4 years, we did preoperative lymphoscintigraphy in 214 patients (pts.). Intraoperative localisation of the SLN with a handheld gamma probe followed in 150 pts. Results: In 214 pts. 247 lymphatic draining regions were found by preoperative scintigraphy. In 3 pts. with melanoma of the cheek no lymphatics/lymphe nodes could be detected. 14 pts. showed interval lymph nodes. In 150 pts. gamma probe guided SLNE was done. In 2 pts. with supraclavicular primary tumor 4 SLN had been defined by preoperative scintigraphy but only 2 could be found intraoperatively. In all other cases (98.7%) the sentinel node was detected correctly by the gamma probe and then removed. In 19 of 150 pts. (12.7%) metastases were detected in the pathologic specimen. The incidence of lymph node metastases showed a continuous increase from 0% at tumor stage pT1 to 44% at stage pT4. Conclusion: SLNE is an accurate method to determine nodal involvement in melanoma and minimizes operative invasiveness in melanoma surgery. (orig.) [Deutsch] Ziel der vorliegenden Arbeit ist die Ueberpruefung der Wertigkeit nuklearmedizinischer Verfahren in der prae- und intraoperativen Diagnostik des Sentinel-Lymphknotens (SLN). Methoden: Bei 214 Patienten fuehrten wir waehrend der vergangenen vier Jahre die praeoperative Lymphszintigraphie und bei 150 Patienten die intraoperative Gammasondenmessung zur Lokalisationsdiagnostik des SLN durch. Ergebnisse: Es fanden sich bei 214 Patienten 247 Abflussgebiete. Bei drei Patienten konnte kein Lymphabfluss nachgewiesen werden. Es handelte sich um Melanome der Wange, zwei dieser Patienten waren voroperiert. 14 Patienten zeigten Intervall-Lymphknoten. Bei 150 Patienten erfolgte eine operative Entfernung des SLN (Sentinel-Lymphonodektomie, SLNE) mit intraoperativer Gammasondenmessung. Bei zwei Patienten mit

  2. Cutaneous leiomyosarcoma.

    Science.gov (United States)

    Porter, Christopher J W; Januszkiewicz, Janek S

    2002-03-01

    Cutaneous leiomyosarcoma is a rare soft-tissue sarcoma with negligible metastatic potential, but local recurrence rates after surgical excision have ranged from 14 percent to 42 percent. Unlike other sarcomas, guidelines for the optimal surgical excision margin of cutaneous leiomyosarcoma are not clearly defined in the existing literature. A review of local experience with this condition revealed eight patients over 12 years, none of whom developed local recurrence or distant metastases. This is despite poor prognostic factors in seven patients and excision margins ranging from 1 to 27 mm. These findings are compared with previously published data, and conclusions are drawn based on analysis of the collective results. Complete surgical excision with a narrow margin is recommended, and patients should be observed for a minimum of 5 years after surgery.

  3. Avaliação do efeito antiparasitário do omeprazol na prevenção do desenvolvimento de lesões cutâneas em hamsters infectados por Leishmania brasiliensis Evaluation of omeprazole's antiparasitary effect preventing the development of cutaneous lesions due to Leishmania brasiliensis in hamsters

    Directory of Open Access Journals (Sweden)

    Hélio Amante Miot

    2005-12-01

    Full Text Available FUNDAMENTOS: A leishmaniose tegumentar americana permanece doença endêmica em diversas regiões brasileiras. A sobrevivência do parasita no interior dos macrófagos se deve, em parte, pela atividade de uma K+/H+-ATPase de membrana que pode ser inibida pelo omeprazol. OBJETIVOS: Avaliar a eficácia do omeprazol na prevenção do desenvolvimento de lesões de leishmaniose em hamsters. MÉTODOS: Empregaram-se 18 hamsters, divididos em três grupos: o grupo L recebeu apenas a inoculação de L. brasiliensis na pata anterior direita, o grupo O recebeu apenas doses diárias de 0,4mg de omeprazol subcutâneo, e o grupo L+O recebeu o inóculo de leishmanias e o tratamento com omeprazol desde o dia da inoculação. O estudo foi conduzido por 42 dias, realizaram-se medidas dos diâmetros das patas semanalmente, e, ao final do estudo, foram realizados esfregaços das lesões para verificação dos parasitas. RESULTADOS: Os hamsters dos grupos L e L+O desenvolveram lesões de leishmaniose tegumentar havendo ulceração em duas patas do grupo L e uma do grupo L+O. Ao final do estudo, a mobilidade e vitalidade no grupo L foram menores que em L+O, e estas menores que no grupo O. Os diâmetros das patas inoculadas nos grupos L e L+O foram significativamente maiores que no início do estudo (pBACKGROUND: Cutaneous leishmaniasis remains an endemic disease in several brazilian regions. The parasite’ survival in macrophages is due to a membrane K+/H+-ATPase that can be inhibited by omeprazole. OBJECTIVES: Evaluate omeprazole’s efficacy preventing the development of cutaneous leishmaniasis in hamsters. METHODS: Eighteen hamsters were divided in 3 groups: the L group received an inoculation of L. brasiliensis on right paw, the O group received daily 0,4mg omeprazole subcutaneously, and L+O group received both omeprazole and the inocule. The study was performed in 42 days, and the measurements of the diameter of paws were done weekly. At the end of the study

  4. [Cutaneous leishmaniasis].

    Science.gov (United States)

    Enk, C D; Gardlo, K; Hochberg, M; Ingber, A; Ruzicka, T

    2003-06-01

    Leishmaniasis is a vector-borne disease caused by an obligate intracellular protozoa, Leishmania, which resides in macrophages. The parasite is transmitted by an infected female sandfly. The incidence of cutaneous leishmaniasis approaches 2 million new cases per year with 90% of the cases occurring in the "Old World", while the "New World" accounts for the rest. Infection may be restricted to the skin with development of characteristic ulcers, or may affect the mucous membranes in its mucocutaneous form. The clinical diagnosis is verified by the presence of amastigotes in slit-skin smears. Therapeutic modalities include systemic treatments such as the pentavalent antimony compound sodium stibogluconate, liposomal formulations of amphotericin B, oral ketoconazole or itraconazole, as well as topical paromomycin sulphate, local heat, freezing with liquid nitrogen, or photodynamic therapy. An effective vaccine is not available.

  5. Cutaneous mucormycosis*

    Science.gov (United States)

    Castrejón-Pérez, Ana Daniela; Welsh, Esperanza C.; Miranda, Ivett; Ocampo-Candiani, Jorge; Welsh, Oliverio

    2017-01-01

    Cutaneous mucormycosis is an emerging fungal infection caused by opportunistic fungi of the phylum Glomeromycota. It is frequent in poorly controlled diabetic patients and individuals with immunosuppression. It is usually acquired by direct inoculation through trauma. The clinical presentation is nonspecific, but an indurated plaque that rapidly evolves to necrosis is a common finding. Diagnosis should be confirmed by demonstration of the etiological agent and new molecular diagnostic tools have recently been described. It is an invasive life-threatening disease and in order to improve survival, a prompt diagnosis and multidisciplinary management should be provided. The treatment of choice is amphotericin B, but new azoles, such as posaconazole and isavuconazole, must be considered.

  6. Cutaneous mucormycosis.

    Science.gov (United States)

    Skiada, Anna; Petrikkos, George

    2013-01-01

    Mucormycosis is an invasive fungal infection caused by fungi of the order Mucorales, mainly affecting immunocompromised patients. Cutaneous mucormycosis is the third most common clinical form of the disease, after pulmonary and rhino-cerebral. The usual factors predisposing to this infection are hematological malignancies and diabetes mellitus, but a significant proportion of patients are immunocompetent. The agents of mucormycosis are ubiquitous in nature and are transmitted to the skin by direct inoculation, as a result of various types of trauma. These include needle sticks, stings and bites by animals, motor vehicle accidents, natural disasters, and burn injuries. The typical presentation of mucormycosis is the necrotic eschar, but it can present with various other signs. The infection can be locally invasive and penetrate into the adjacent fat, muscle, fascia, and bone, or become disseminated. Diagnosis is difficult because of the nonspecific findings of mucormycosis. Biopsy and culture should be performed. The treatment of mucormycosis is multimodal and consists of surgical debridement, use of antifungal drugs (amphotericin B and posaconazole), and reversal of underlying risk factors, when possible. Mortality rates, although lower than in other forms of the disease, are significant, ranging from 4% to 10% when the infection is localized.

  7. Les blogs

    OpenAIRE

    Angé, Caroline; Bigey, Magali; Broudoux, Évelyne; Candel, Étienne; Chapelain, Brigitte; Couleau, Christèle; Deseilligny, Oriane; di Rosario, Giovanna; Escolin-Contensou, Isabelle; Gefen, Alexandre; Hellégouarc’h, Pascale; Jeanne-Perrier, Valérie; Labbé, Mathilde; Massip, Bernard; Paloque-Berges, Camille

    2014-01-01

    Parler de genre à propos des blogs, c’est moins chercher à découvrir une espèce littéraire nouvelle dans ce corpus hétérogène et massif que tenter de définir, au-delà des spécifications techniques et fonctionnelles, un objet esthétique. Le blog s’écrit contre les genres existants, mais en porte l’empreinte autant qu’il en déplace les lignes. Il invente aussi ses usages, ses communautés, ses configurations poétiques – autant de caractéristiques par lesquelles il fait genre. Les déclinaisons mu...

  8. The place of high dose rate curie-therapy in cutaneous cancers: experience of the Neufchatel hospital on 140 patients; Place de la curietherapie de haut debit de dose dans les cancers cutanes: experience de l'hopital neuchatelois a propos de 140 patients

    Energy Technology Data Exchange (ETDEWEB)

    Yanes, B.; Fraija, L.; Guibert, G.; Notter, M. [Hopital neuchatelois, La Chaux-de-Fonds (Switzerland)

    2011-10-15

    The authors report the experience of the Neufchatel hospital in the treatment by curie-therapy of 140 patients exhibiting cutaneous cancers. The apparatus comprised an iridium 192 source and a Leipzig-type applicator. The distributions of carcinoma type and treated localizations are indicated. Results are analyzed in terms of age, tumour size, aesthetic result, local control for the different types of carcinomas. Short communication

  9. Les aciers inoxydables dans les fixations

    CERN Document Server

    CETIM

    2010-01-01

    Cet ouvrage, qui fait la synthèse de plusieurs travaux menés par le Cetim, propose une vue d'ensemble sur les aciers inoxydables utilisés pour les fixations. Au sommaire : les normes EN, ISO et ATSM qui s'y rapportent , les désignations symboliques , les nuances et caractéristiques mécaniques , les différentes formes de corrosion, les méthodes pour les détecter , les règles du métier , les mises en oeuvre. L'ouvrage comprend plusieurs fiches matériaux et des tableaux qui présentent les équivalences entre les désignations.

  10. Cutaneous nerve entrapment syndrome

    Institute of Scientific and Technical Information of China (English)

    DongFuhui

    2004-01-01

    The cutaneous nerve entrapment syndrome is named that, the cutaneous nerve's functional disorder caused by some chronic entrapment, moreover appears a series of nerve's feeling obstacle,vegetative nerve function obstacle, nutrition obstacle, even motor function obstacle in various degree.

  11. Clinical relevance of positron emission tomography for initial staging and follow-up of malignant melanoma; Klinischer Stellenwert der Positronenemissionstomographie im Primaerstaging und in der Nachsorge des malignen Melanoms

    Energy Technology Data Exchange (ETDEWEB)

    Baum, R.P. [Zentralklinik Bad Berka GmbH (Germany). Klinik fuer Nuklearmedizin/PET-Zentrum; Rinne, D.; Kaufmann, R. [Frankfurt Univ. (Germany). Klinik fuer Dermatologie und Venerologie

    2000-12-01

    and evaluation of patients with melanoma in the USA. (orig.) [German] Die Inzidenz des malignen Melanoms steigt weltweit mit etwa 5% pro Jahr rasch an. In Europa betraegt die Erkrankungshaeufigkeit etwa 10-12 neue Erkrankungsfaelle pro 100 000 Einwohner. Der wichtigste prognostische Faktor ist das Primaertumorstadium (Clark-Level und vertikale Tumordicke nach BRESLOW). Bei einer Tumordicke <1,5 mm betraegt die 10-Jahre-Ueberlebensrate 90%, mit einer Tumordicke von >1,5 mm sinkt sie auf 65%. Die 5-Jahres-Ueberlebensrate liegt zwischen 15 und 50% bei regionalem Lymphknotenbefall und unter 5% bei disseminierter Erkrankung. Zum Primaerstaging werden ueblicherweise als konventionelle bildgebende Verfahren die Roentgenthoraxuntersuchung, die Lymphknotensonographie und Laboruntersuchungen eingesetzt. Die Sentinel-Node-Biopsie gewinnt zunehmend an Bedeutung, da das Melanom haeufig in die regionalen Lymphknoten metastasiert. CT-Thorax oder Abdomen sowie die kraniale MRT und andere Verfahren werden symptombezogen eingesetzt. Die Ganzkoerper-FDG-PET zeigte sich in einer prospektiven Studie bei 100 Patienten mit Hochrisikomelanom (Primaerstaging n=48) bzw. zum Restaging bei Verdacht auf Rezidiv oder Progression (n=52) der konventionellen bildgebenden Diagnostik ueberlegen (mit Ausnahme des Hirnmetastasennachweises). Die diagnostische Genauigkeit der PET zum Metastasennachweis betrug 92,1%, die der konventionellen Bildgebung 55,7% (p<0,001). Uebereinstimmend mit weiteren Publikationen, den Empfehlungen der Deutschen Konsensuskonferenz 1997 und des ICP halten wir die FDG-PET beim Melanom fuer sinnvoll zum: Nachweis von okkulten Lymphknotenmetastasen oder Fernmetastasen, in der Primaerdiagnostik von Patienten mit einem malignen kutanen Melanom mit einer Tumordicke >1,5 mm sowie zum Nachweis okkulter Metastasen bei Patienten mit einem Rezidiv vor geplanten chirurgischen Eingriffen. Die PET aendert haeufig das diagnostische Vorgehen und fuehrt zur Veraenderung des therapeutischen

  12. Corynebacterium striatum infecting a malignant cutaneous lesion: the emergence of an opportunistic pathogen Corynebacterium striatum infectando lesão cutânea maligna: a emergência de um patógeno oportunista

    Directory of Open Access Journals (Sweden)

    Silvana Vargas Superti

    2009-04-01

    Full Text Available We described a case of a 27-year old male patient with skin and soft tissue infection of a neoplastic lesion caused by Corynebacterium striatum, an organism which has been rarely described as a human pathogen. Identification was confirmed by DNA sequencing. Successful treatment with penicillin was achieved. The role of the C. striatum as an emerging opportunistic pathogen is discussed.Descrevemos infecção de lesão neoplásica em paciente masculino de 27 anos, envolvendo pele e partes moles, causada por Corynebacterium striatum, um microrganismo raramente descrito como patógeno humano. A identificação foi confirmada por seqüenciamento de DNA. O paciente foi tratado com penicilina, com sucesso. O papel do C. striatum como patógeno oportunista é discutido.

  13. Les choses…

    Directory of Open Access Journals (Sweden)

    Pierre Curie

    2012-05-01

    Full Text Available Dans la culture tant des Monuments historiques que de l’Université française, le monumental a longtemps prévalu sur l’objet, peinture, sculpture ou objet d’art qui, lui, dans l’inconscient collectif, relevait tout naturellement du musée. Dans la pensée et dans les goûts d’André Chastel, les catégories n’étaient pas aussi manichéennes et à l’Inventaire, malgré une certaine prééminence de l’architecture, l’objet - au sens large - tint, dès le début de l’aventure, une place non négligeable. Le premier des Vocabulaires parus, en 1969, fut consacré à la tapisserie, suivi, en une vingtaine d’années, par la sculpture, les objets et le mobilier civil domestique, le vitrail…In the culture of France’s historic monuments, as in French universities, the monumental has long been considered as more important than sculptures or works of art, generally seen as more to do with museums. In the writings and tastes of André Chastel, however, the categories were not so clear-cut and, at the French Inventory, although architecture has enjoyed a certain pre-eminence, the object, in the broadest sense of the term, has been taken into consideration form the outset. Over 17,000 items now feature in the national database Palissy, on moveable objects. The first scientific vocabulary, published by the Inventory services in 1969, was devoted to tapestry and, over the last twenty years, other vocabularies have dealt with sculpture, domestic civil furniture and stained glass.

  14. Les incommensurables

    CERN Document Server

    Houdart, Sophie

    2015-01-01

    Le Large Hadron Collider, ou grand collisionneur de hadrons, est l'accélérateur de particules le plus grand et le plus puissant du monde. Prenant la forme d'un anneau de 26,659 kilomètres de circonférence, lové 100 mètres sous terre et officiellement domicilié à Meyrin, à la frontière de la France et de la Suisse, il est constitué d'aimants supraconducteurs et de structures accélératrices qui augmentent l'énergie des particules qui y circulent. Chaque jour, à l'intérieur de l'accélérateur, deux faisceaux de particules qui circulent en sens contraire à des énergies très élevées avant de rentrer en collision l'un avec l'autre. Les particules, lancées à 99,9999991 % de la vitesse de la lumière, effectuent 11245 fois le tour de l'accélérateur par seconde et entrent en collision quelque 600 millions de fois par seconde. Les Incommensurables est une minutieuse enquête de terrain sur cette "cathédrale" enfouie qui offre la possibilité de se connecter à l'immensité et aux mystères de...

  15. Aspectos epidemiológicos de pacientes com lesões ungueais e cutâneas causadas por Scytalidium spp Epidemiological aspects of patients with ungual and cutaneous lesions caused by Scytalidium spp

    Directory of Open Access Journals (Sweden)

    Ana Paula Martins Xavier

    2010-12-01

    Full Text Available FUNDAMENTO: As dermatomicoses causadas por fungos filamentosos não dermatófitos são infecções raras, exceto as onicomicoses, cuja prevalência vem crescendo nos últimos anos. Dentre esses agentes etiológicos destacam-se o Scytalidium dimidiatum e o S. hyalinum, fungos emergentes responsáveis por micoses em unhas e pele. OBJETIVO: Investigar as características epidemiológicas das onicomicoses e micoses de outras localizações causadas pelos fungos do gênero Scytalidium, utilizando-se como parâmetros sexo, idade e localizações das lesões. MÉTODOS: Avaliaram-se 81 amostras com cultura positiva para o gênero em estudo, oriundas de 74 pacientes encaminhados ao Laboratório de Investigação em Dermatologia (ID situado na cidade do Rio de Janeiro (RJ, no período de 1997 a 2006. As amostras foram submetidas a confirmação diagnóstica por exame direto e cultura. RESULTADOS: A prevalência de onicomicoses por Scytalidium spp. foi de 0,87%, entre as idades de 41 e 60 anos (48,64%. Em relação à localização das lesões, os pés foram mais acometidos (91,36%, com predomínio do hálux esquerdo. No exame direto, as estruturas mais encontradas foram hifas hialinas; na cultura, a espécie S. dimidiatum foi a mais frequente. CONCLUSÃO: As onicomicoses por Scytalidium spp. são raras e o S. dimidiatum foi a espécie mais isolada neste laboratório no período em estudo.BACKGROUND: Dermatomycoses caused by non-dermatophyte filamentous fungi are rare infections, except for onychomycosis, whose prevalence has increased over the past few years. Among these etiologic agents, we highlight Scytalidium dimidiatum and S. hyalinum, emergent fungi that cause mycoses that affect the nails and skin. OBJECTIVE: To investigate the characteristics of onychomycosis and other mycoses caused by the fungi Scytalidium spp, using sex, age and site of infection as parameters. METHODS: Eighty-one samples were evaluated showing positive culture for Scytalidium

  16. Les expositions

    OpenAIRE

    2016-01-01

    Liré Musée Joachim Du Bellay. Jeux et divertissements à la Renaissance Depuis le vernissage du samedi 26 avril 2008 et jusqu’au 31 octobre 2008, l’exposition Jeux et divertissements à la Renaissance a été proposée au public par le Musée. Des panneaux expliquaient et illustraient les amusements de la Renaissance : danses, théâtre, jeux de sociétés, fêtes, tournois, jeu de paume… Des jeux étaient à disposition pour tester ses connaissances, s’essayer aux jeux de sociétés ou d’adresse de l’époqu...

  17. Naevus Lipomatosus Cutaneous Superficialis

    Directory of Open Access Journals (Sweden)

    Ramanan C

    2001-01-01

    Full Text Available Naevus lipomatosus cutaneous superficialis (NLCS in an eighteen year old female is reported. She had asymptomatic nodules and plaques on her lower back since birth. The diagnosis was confirmed by histopathology

  18. Nevus lipomatosus cutaneous superficialis*

    Science.gov (United States)

    Carvalho, Gustavo de Sá Menezes; Cavalcanti, Silvana Maria de Morais; Herênio, Alzinira Souza; Teixeira, Márcia Almeida Galvão; de Alencar, Eliane Ruth Barbosa; Gonçalves, Sergio Paulo Mendes

    2016-01-01

    We report a case of nevus lipomatosus cutaneous superficialis of Hoffman-Zurhelle (NCLS), with multiple lesions, in a ten-year-old child. The NLCS is considered rare. The classical clinical presentation is characterized by multiple skin-colored or yellowish papules and nodules, which can have a linear distribution. Histologically, it is characterized by the presence of mature ectopic adipocytes in the dermis. The main therapeutic option is surgical excision. The classical Nevus lipomatosus cutaneous superficialis is reported in this case.

  19. Les torsions sur testicules cryptorchides

    Science.gov (United States)

    Gharbi, Mohamed; Amri, Najmeddine; Chambeh, Wahib; Braiek, Salem; Kamel, Rafik El

    2010-01-01

    Résumé But : La cryptorchidie est une pathologie assez fréquente en urologie. Elle est associée à un risque élevé d’infertilité et de dégénérescence. Elle semble aussi être associée à un risque important de torsion. Cette entité est très peu abordée dans la littérature. Nous rapportons tous les cas de torsion sur testicule cryptorchide observés à notre service dans le but de mieux caractériser cette pathologie et de réduire ainsi le taux d’orchidectomies. Méthodologie : Il s’agit d’une étude rétrospective portant sur tous les cas de torsion sur testicule cryptorchide opérés dans notre service d’urologie entre 1999 et 2007. Les patients ont fait l’objet d’une description basée sur le résumé de leurs observations. Résultats : Les patients étaient âgés de 7 mois à 39 ans. La torsion touchait le testicule droit dans 53 % des cas. Le tableau clinique comportait une douleur au niveau de la région inguinale d’apparition soudaine avec une masse sous-cutanée inflammatoire et douloureuse à ce niveau et surtout un hémiscrotum homolatéral vide. Dans 60 % des cas, le diagnostic était tardif et une orchidectomie a été réalisée. Dans les autre cas, un abaissement du testicule a été réalisé avec orchidopexie controlatéral dans le même temps opératoire. Conclusion : Bien qu’il s’agisse d’une pathologie peu courante, la torsion sur testicule cryptorchide doit être étudiée davantage. Le diagnostic précoce permettra de sauver et d’abaisser le testicule et faciliter ainsi le dépistage d’une éventuelle dégénérescence. PMID:21191497

  20. Comment les jeunes gens utilisent les cartes

    Directory of Open Access Journals (Sweden)

    H. Sandford

    1990-09-01

    Full Text Available Des recherches sur l’utilisation des cartes dans les collèges et les lycées révèlent une hiérarchie de procédés qui met au jour des lacunes dans la formation au niveau secondaire.

  1. Cutaneous histiocytosis syndromes.

    Science.gov (United States)

    Roper, S S; Spraker, M K

    1985-11-01

    Cutaneous histiocytosis may take two principal forms. It is either a benign proliferative process or a relentless, progressive process with a poor prognosis. In histiocytic medullary reticulosis, histiocytes demonstrate nuclear atypia and the outcome is uniformly fatal. Benign cephalic histiocytosis X causes lesions similar to those of histiocytosis X, but Langerhans' cells are absent. In congenital self-healing histiocytosis X, the Letterer-Siwe-like cutaneous infiltrate contains Langerhans' cells, but the lesions heal spontaneously without treatment. The nodular cutaneous lesions of juvenile xanthogranuloma appear in infancy and resolve without treatment; however, the higher percentage (10%) of associated ocular lesions may lead to glaucoma and blindness. In histiocytosis X, the cutaneous lesions show a marked proliferation of Langerhans' cells, with prognosis dependent on the patient's age and the extent of organ dysfunction. Patients who survive the acute form of the disease may develop diabetes insipidus, growth retardation, pulmonary fibrosis, and biliary cirrhosis. A subtle immunologic defect has been identified in patients with histiocytosis X, yet the pathogenesis of the disease is still speculative. Familial disease occurring in early infancy should be differentiated from complete or partial immunodeficiency syndromes. Guidelines for evaluating patients with cutaneous histiocytosis are reviewed.

  2. Cutaneous metastases of hepatocellular carcinoma.

    Science.gov (United States)

    Lazaro, M; Serrano, M L; Allende, I; Ratón, J A; Acebo, E; Diaz-Perez, J L

    2009-12-01

    Cutaneous metastases are an unusual finding that may present as the first sign of an internal neoplasia. A case of cutaneous metastases of hepatocellular carcinoma, which may often involve other organs but very rarely metastases to the skin, is reported.

  3. Les classiques, les modernes et nous

    Directory of Open Access Journals (Sweden)

    François Hartog

    2010-06-01

    Full Text Available Quelle est la place des études classiques aujourd'hui, qu'a-t-elle été, que peut-elle être encore? Dans la longue durée de l'histoire européenne, nous nous arrêterons sur les opérations  que le  recours aux anciens possible. Quels gestes ont-ils suscité? Quelles configurations ont été incessamment reprises, scrutées, investies et réinvesties au cours des siècles: le couple formé par les ancients et les modernes, mais aussi dans leur sillage les sauvages ou les barbares face aux civilisés, les classiques, face aux romantiquesavec des préclassiques et pui des néoclassiques...A travers leurs interrelations et leurs oppositions, se dessine, en fait, le mouvement continué de production de la culture moderne de l'Europe , où le couple des anciens et des modernes a longtemps tenus un des premiers ròles, avec sa longue histoire de "querelles"

  4. Update on cutaneous calciphylaxis

    Directory of Open Access Journals (Sweden)

    Uwe Wollina

    2013-01-01

    Full Text Available Calciphylaxis is a devastating disorder with a mortality rate of 80% due to sepsis and organ failure. Hallmarks of this rare disease are arteriolar media calcification, thrombotic cutaneous ischemia, and necrotic ulcerations. Different mechanisms of vascular calcification can lead to calciphylaxis. Early diagnosis by deep cutaneous ulcer biopsy is most important for prognosis. Here, dermatologists play a significant role although treatment usually needs an interdisciplinary approach. Surgical procedures had been the cornerstone of treatment in the past including parathyroidectomy, but recently new medical treatments emerged aiming to normalize disturbances of minerals to reduce the serum concentration of sodium phosphate and to prevent precipitation and calcification. Multimodal therapy is warranted but only aggressive surgical debridement of cutaneous ulcers has shown significant outcome improvement.

  5. Cutaneous signs of piety.

    Science.gov (United States)

    Ramesh, V; Al Aboud, Khalid

    2014-07-01

    It is important for dermatologists to be aware of cutaneous changes related to religious practices to help in their recognition and management. The anatomic location of cutaneous lesions associated with friction from praying varies based on religious practice. Allergic contact dermatitis from products and substances commonly used in worshipping also vary by religion. Some religious practices may render individuals prone to infections that manifest on the skin. Tattoos of godly figures also may adorn the body. Religious practices also have been implicated in cases of urticaria, köbnerization, and leukoderma. This article reviews the clinical presentation of some of the most common cutaneous changes that occur in individuals who practice the following religions: Christianity, Islam, Judaism, Hinduism, and Sikhism.

  6. Les risques du travail

    CERN Document Server

    Thébaud-Mony, Annie

    2015-01-01

    Depuis les années 1990, les conditions de travail se sont peu à peu imposées dans le débat social. Néanmoins, la situation reste critique. Les risques traditionnels n'ont pas disparu : les manutentions lourdes, l'exposition professionnelle aux cancérogènes, au bruit ou aux vibrations demeurent répandues... De plus, certaines " améliorations " n'ont fait que déplacer et dissimuler les problèmes, telle l'externalisation des risques grâce à la sous-traitance. Dans le même temps, les transformations du travail et des modalités de gestion de la main-d'œuvre ont fragilisé les collectifs et accru l'isolement des salariés, conduisant à une montée visible de la souffrance psychique. Face à ces évolutions, il est plus que jamais nécessaire que tous les acteurs concernés, en particulier les salariés eux-mêmes et leurs représentants, s'approprient les connaissances indispensables pour améliorer la protection de la santé sur les lieux du travail. Tel est le but de ce livre, qui renouvelle int�...

  7. Cutaneous histiocytosis in dogs.

    Science.gov (United States)

    Mays, M B; Bergeron, J A

    1986-02-15

    Multifocal cutaneous histiocytic lesions were recognized in 9 dogs. Clinically, the dogs had multiple erythematous plaques or nodules in the skin (1 to 5 cm diameter). Histologically, the lesions were comprised of dermal or pannicular infiltrates of large histiocytic cells, with varying numbers of other inflammatory cells intermixed. By electron microscopy, the cells resembled those of canine cutaneous histiocytoma. The lesions seemed to wax and wane and appeared in new sites, regardless of treatment. The dogs ranged in age from 2 to 13 years; 7 dogs were under 6 years of age. Both sexes and various breeds were represented. An infectious agent could not be identified.

  8. Cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Biazar, Cyrus; Sigges, Johanna; Patsinakidis, Nikolaos

    2013-01-01

    In this prospective, cross-sectional, multicenter study, we assessed clinical and laboratory characteristics from patients with cutaneous lupus erythematosus (CLE) using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). 1002 (768 females, 234 males...... included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. The mean age at onset of disease was 43.0±15.7 years...

  9. Primary cutaneous leiomysarcoma

    Directory of Open Access Journals (Sweden)

    Shubhangi Vinayak Agale

    2011-01-01

    Full Text Available Primary cutaneous leiomyosarcoma of the skin is a rare soft tissue neoplasm, accounting for about 2-3% of all superficial soft tissue sarcomas. It arises between the ages of 50 and 70 years, and shows a greater predilection for the lower extremities. Clinically, it presents with solitary, well-circumscribed nodule and, microscopically, consists of fascicles of spindle-shaped cells with "cigar-shaped" nuclei. Local recurrence is known in this tumor. We document a case of primary cutaneous leiomyosarcoma in a 77-year-old man and discuss the histological features and immunohistochemical profile of this uncommon neoplasm.

  10. The expression of NGFr and PGP 9.5 in leprosy reactional cutaneous lesions: an assessment of the nerve fiber status using immunostaining Expressão de NGFr e PGP 9.5 nas lesões cutâneas reacionais da hanseníase: uma avaliação do status das fibras nervosas utilizando imunomarcação

    Directory of Open Access Journals (Sweden)

    Sérgio Luiz Gomes Antunes

    2003-06-01

    Full Text Available The effects of reactional episodes on the cutaneous nerve fibers of leprosy patients was assessed in six patients (three with reversal reactions and three with erythema nodosum leprosum. Cryosections of cutaneous biopsy of reactional lesions taken during the episode and of another sample during the remission period were immunostained with anti-NGFr and anti-PGP 9.5 (indirect immunofluorescence. We found no significant statistical difference in the number of NGFr- and PGP 9.5-positive fibers between the reactional and post-reactional groups. A significant difference was detected between the number of NGFr and PGP 9.5-stained fibers inside of the reactional group of biopsy cryosections but this difference was ascribed to the distinct aspects of the nerve fibers displayed whether stained with anti-NGFr or with anti-PGP 9.5; NGFr-positive branches looked larger and so interpreted as containing more fibers. In addition, a substantial number NGFr-positive fibers were PGP 9.5-negative. No differences in the number of stained fibers among the distinct cutaneous regions examined (epidermis + upper dermis, mid and deep dermis was detected. In conclusion, the number of PGP- and NGFr-positive fibers were not significantly different in the reactional and post-reactional biopsies in the present study. NGFr-staining of the nerve fibers is different from their PGP-imunoreactivity and the evaluation of the nerve fiber status on an innervated target organ should be carried out choosing markers for both components of nerve fibers (Schwann cells and axons.O efeito das reações hansenianas sobre a inervação cutânea de pacientes hansenianos foi avaliado em seis pacientes (três com reação reversa e três com eritema nodoso leprosum. Cortes congelados de biópsias de lesões cutâneas reacionais colhidas na ocasião da reação e de biópsias colhidas após a remissão do quadro reacional na mesma região ocupada previamente pela lesão foram marcados pela t

  11. The Cutaneous Rabbit Revisited

    Science.gov (United States)

    Flach, Rudiger; Haggard, Patrick

    2006-01-01

    In the cutaneous rabbit effect (CRE), a tactile event (so-called attractee tap) is mislocalized toward an adjacent attractor tap. The effect depends on the time interval between the taps. The authors delivered sequences of taps to the forearm and asked participants to report the location of one of the taps. The authors replicated the original CRE…

  12. Primaty Cutaneous Histoplasmosis

    Directory of Open Access Journals (Sweden)

    Nair S

    2000-01-01

    Full Text Available A 29-year old woman presented with diffuse swelling of the base of the right thumb along with ulceration. X-ray indicated bony damage. Histopathology showed PAS positive intracellular organisms suggestive of histoplasmosis. We are reporting a very rare case of primary cutaneous histoplasmosis from this part of the country.

  13. Les Cahiers du CREAD

    African Journals Online (AJOL)

    Admin

    les littératures économique et gestionnaire, mais souvent dans ces travaux, l'effet de ... chiffre d'affaires du nouvel ensemble résultant de la vente des produits mieux .... syndicalisme, droit de grève), fiscales (différents taux d'imposition, etc.) .... nouvel ensemble et aussi, les différentes relations avec les alliances verticales ...

  14. Les outils du CERN

    CERN Multimedia

    1999-01-01

    C'est le plus grand centre mondial de recherche en physique des particules. Les outils du Laboratoire, accélérateurs et détecteurs de particules, figurent parmi les instruments scientifiques les plus complexes au monde. Des prix Nobels ont d'ailleurs été attribués aux physiciens du CERN pour leurs développements.

  15. Kyste hydatique sous cutané isolé: à propos d’un cas et revue de la literature

    Science.gov (United States)

    Lemrhari, Bahija; Baha, Hasna; Azzouzi, Soufia; Chiheb, Soumyia

    2016-01-01

    La localisation sous cutanée, primitive et isolée, du kyste hydatique est exceptionnelle, même dans les pays où la maladie hydatique est endémique. Nous rapportons le cas d’une jeune patiente présentant un kyste hydatique sous cutané sans atteintes viscérales associées. PMID:27800067

  16. Les Nymphes dans les rites du mariage

    OpenAIRE

    2013-01-01

    Le champ du mariage (où l’on rencontre à la fois les Nymphes puissances surnaturelles et les numphai humaines) peut se révéler intéressant pour croiser des données littéraires, archéologiques et épigraphiques sur le culte des Nymphes. Lors des préliminaires, ces puissances peuvent être l’objet des protéléia (sacrifices prénuptiaux) ou être associées avec la loutrophorie et le bain prénuptial. Les Nymphes n’interviennent guère pendant la journée de célébration du mariage, sauf dans des textes ...

  17. [Cutaneous tuberculosis: case report].

    Science.gov (United States)

    Bisero, Elsa; Luque, Graciela; Melillo, Karina; Favier, María Inés; Zapata, Alejandra; Cuello, María Soledad

    2014-06-01

    Cutaneous tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. It is not very frequent and particularly difficult to diagnose. It incidence ranges between 1.5 and 4% of all extrapulmonary tuberculosis, according to bibliography. The clinic presentations depend on the arrival via of the bacillus to the skin, the patient's immune state and the environment. We show a cutaneous tuberculosis on a child with chronic dermatologic lesions, with torpid evolution, without response to treatments; the skin biopsy showed caseous granulomas. The aim is to show a patient with an infrequent clinic presentation of this disease, to emphasize the importance of an early recognition and treatment, avoiding the appearance of complications and sequels.

  18. Cutaneous mercury granuloma

    OpenAIRE

    Kalpana A Bothale; Mahore, Sadhana D.; Sushil Pande; Trupti Dongre

    2013-01-01

    Cutaneous mercury granuloma is rarely encountered. Clinically it may pose difficulty in diagnosis. Here, we report a 23-year-old male presented with erythematous, nodular lesions over the forearm and anterior aspect of chest wall. Metallic mercury in tissue sections appear as dark black, opaque, spherical globules of varying size and number. They are surrounded by granulomatous foreign-body reaction. It is composed of foreign body giant cells and mixed inflammatory infiltrate composed of hist...

  19. Les trous noirs

    CERN Document Server

    Ioli, Elena

    2016-01-01

    L'univers est peuplé par des étoiles, des planètes, des galaxies, des astéroïdes, des comètes, mais les trous noirs en sont certainement les habitants les plus mystérieux et les plus fascinants ! Grâce à cette merveilleuse histoire racontée par papy Gino, professeur d'astronomie, les trous noirs n auront plus de secrets pour vous ! C est l'été, le soleil illumine le ciel, la plage est en feu : une journée à la plage pleine de jeux et de plongée qui va se transformer pour Bernardo, Gregorio et leurs deux amis en une aventure inattendue. Ils découvriront les secrets des trous noirs, d étranges objets célestes que personne n'a jamais vus mais qui existent bel et bien ! Grand-père Gino, un professeur d astronomie à la retraite, emmènera les enfants à l'intérieur d'un trou noir, leur expliquera pourquoi ils sont noirs, comment ils sont nés et comment les scientifiques pensent qu'ils vont mourir. Et Gino leur racontera même ce qui se trouve de l'autre côté d'un trou noir...

  20. Cutavirus in Cutaneous Malignant Melanoma

    DEFF Research Database (Denmark)

    Mollerup, Sarah; Fridholm, Helena; Vinner, Lasse

    2017-01-01

    A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains to be in......A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains...

  1. Cutavirus in Cutaneous Malignant Melanoma

    DEFF Research Database (Denmark)

    Mollerup, Sarah; Fridholm, Helena; Vinner, Lasse

    2017-01-01

    A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains to be in......A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains...

  2. Lesões de pele causadas pelos espinhos de Mimosa pudica (Leg. Mimosoideae nos membros de bovinos e ovinos no estado do Pará Cutaneous lesions of the legs caused by the thorns of Mimosa pudica (Leg. Mimosoideae in cattle and sheep in the State of Pará

    Directory of Open Access Journals (Sweden)

    José Diomedes Barbosa

    2009-05-01

    Full Text Available Foi estudada uma doença em bovinos e ovinos caracterizada por lesões ulcerativas e granulomatosas da pele dos membros. Os estudos epidemiológicos e patológicos permitiram concluir que essas lesões são causadas pelos espinhos de Mimosa pudica (Leg. Mimosoideae. A doença foi observada somente em pastagens acentuadamente infestadas e os animais se recuperaram rapidamente após retirados destes pastos. Nos ovinos as lesões atingiam partes mais altas dos membros do que nos bovinos, devido ao seu menor porte.A condition of cattle and sheep characterized by ulcerous and granulomatous skin lesions of the legs was studied. Epidemiological data and the nature of the lesions indicate that they are caused by the thorns of Mimosa pudica (Leg. Mimosoideae. The disease was observed only in pastures largely infested by the plant, and animals recover quickly when moved from them.

  3. [Adhesive cutaneous pharmaceutical forms].

    Science.gov (United States)

    Gafiţanu, E; Matei, I; Mungiu, O C; Pavelescu, M; Mîndreci, I; Apostol, I; Ionescu, G

    1989-01-01

    The adhesive cutaneous pharmaceutical forms aimed to local action release the drug substance in view of a dermatological, traumatological, antirheumatic, cosmetic action. Two such preparations were obtained and their stability, consistency and pH were determined. The "in vitro" tests of their bioavailability revealed the dynamics of calcium ions release according to the associations of each preparation. The bioavailability determined by evaluating the pharmacological response demonstrated the antiinflammatory action obtained by the association of calcium ions with the components extracted from poplar muds. The therapeutical efficiency of the studied preparations has proved in the treatment of some sport injuries.

  4. Chronic zosteriform cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Omidian M

    2006-01-01

    Full Text Available Cutaneous leishmanasis (CL may present with unusual clinical variants such as acute paronychial, annular, palmoplantar, zosteriform, erysipeloid, and sporotrichoid. The zosteriform variant has rarely been reported. Unusual lesions may be morphologically attributed to an altered host response or owing to an atypical strain of parasites in these lesions. We report a patient with CL in a multidermatomal pattern on the back and buttock of a man in Khozestan province in the south of Iran. To our knowledge, this is the first reported case of multidermatomal zosteriform CL. It was resistant to conventional treatment but responded well to a combination of meglumine antimoniate, allopurinol, and cryotherapy.

  5. [Cutaneous histiocytosis X].

    Science.gov (United States)

    Metz, J; Metz, G; Lechner, W

    1980-09-01

    Histiocytosis X comprises three clinical entities whose common substrate is a localized or systemic proliferation of atypical histiocytes. On the basis of the age of manifestation, acuity of the clinical course and organ involvement Abt-Letterer-Siwe's disease, Hand-Schüller-Christian's disease and eosinophilic granuloma can be differentiated from each other, although transitional varieties of these syndromes are possible. Not infrequently oligosymptomatic forms are misinterpreted, especially when the skin is the only involved organ. In the following case report cutaneous histiocytosis X will be discussed in terms of its clinical expression. Electron-microscopy has proved to be the best methods to make the diagnosis of such atypical cases.

  6. Pure cutaneous histiocytosis X.

    Science.gov (United States)

    Magaña-García, M

    1986-03-01

    A 38-month-old boy presented with nodules in the skin of the genital region present for 2 1/2 years. These later spread to the skin of the trunk, head, and extremities. A complete clinical workup could not reveal involvement in any other organ sites and biopsy of one of the cutaneous lesions was diagnosed as histiocytosis X. Because the child was in generally good condition, no treatment was given. Follow-up revealed that the disease had remained limited to the skin, where 15% of the lesions disappeared spontaneously.

  7. Cutaneous mucormycosis postcosmetic surgery

    Science.gov (United States)

    Al-Tarrah, Khaled; Abdelaty, Mahmoud; Behbahani, Ahmad; Mokaddas, Eman; Soliman, Helmy; Albader, Ahdi

    2016-01-01

    Abstract Background: Mucormycosis is a rare, aggressive, and life-threatening infection that is caused by organisms belonging to the order Mucorales. It is usually acquired through direct means and virtually always affects immunocompromised patients with the port of entry reflecting the site of infection, in this case, cutaneous. Unlike other mucormycoses, patients affected by Apophysomyces elegans (A elegans) are known to be immunocompetent. This locally aggressive disease penetrates through different tissue plains invading adjacent muscles, fascia, and even bone causing extensive morbidity and may prove fatal if treated inadequately. Cutaneous mucormycosis is associated with disruption of cutaneous barriers such as trauma. However, rarely, it may be iatrogenic. No cases have been previously reported postcosmetic surgery, especially one that is so commonly performed, lipofilling. Case Report: The patient is a, previously healthy, 41-year-old middle-eastern female who was admitted to the plastic surgery department 17 days after undergoing cosmetic surgery. She suffered from extensive tissue inflammation and necrosis in both gluteal regions. Following admission, she was initially started on empirical antimicrobial therapy which was changed to an antifungal agent, voriconazole, when preliminary microbiological results showed filamentous fungi. This was discontinued and liposomal amphotericin B was commenced when further mycological analysis identified A elegans. Furthermore, she underwent a total of 10 sessions of extensive debridement to the extent that portions of the sacrum and left femoral head became exposed. Her clinical status and wounds improved with the appropriate management and she remained an inpatient for 62 days. Subsequently, she had defects in both gluteal regions which required reconstructive surgery. Conclusion: A elegans is an uncommon cause of iatrogenic cutaneous mucormycosis. A high index of clinical suspicion is required, especially in the

  8. Corynebacterium ulcerans cutaneous diphtheria.

    Science.gov (United States)

    Moore, Luke S P; Leslie, Asuka; Meltzer, Margie; Sandison, Ann; Efstratiou, Androulla; Sriskandan, Shiranee

    2015-09-01

    We describe the case of a patient with cutaneous diphtheria caused by toxigenic Corynebacterium ulcerans who developed a right hand flexor sheath infection and symptoms of sepsis such as fever, tachycardia, and elevated C-reactive protein, after contact with domestic cats and dogs, and a fox. We summarise the epidemiology, clinical presentation, microbiology, diagnosis, therapy, and public health aspects of this disease, with emphasis on improving recognition. In many European countries, C ulcerans has become the organism commonly associated with cutaneous diphtheria, usually seen as an imported tropical disease or resulting from contact with domestic and agricultural animals. Diagnosis relies on bacterial culture and confirmation of toxin production, with management requiring appropriate antimicrobial therapy and prompt administration of antitoxin, if necessary. Early diagnosis is essential for implementation of control measures and clear guidelines are needed to assist clinicians in managing clinical diphtheria. This case was a catalyst to the redrafting of the 2014 national UK interim guidelines for the public health management of diphtheria, released as final guidelines in March, 2015. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Cutaneous polyarteritis nodosa: A rare isolated cutaneous vasculitis

    Directory of Open Access Journals (Sweden)

    Praveen Kumar A Subbanna

    2012-01-01

    Full Text Available Cutaneous polyarteritis nodosa (CPAN is a rare form of cutaneous vasculitis that involves small and medium sized arteries of the dermis and subcutaneous tissue without systemic involvement. It presents with tender subcutaneous nodules, digital gangrene, livedo reticularis and subcutaneous ulcerations. The diagnosis is by skin biopsy and characteristic pathologic feature is a leukocytoclastic vasculitis in the small to medium-sized arterioles of the dermis. We report a rare case of benign cutaneous PAN in a 14-year-old girl who presented with history of fever, subcutaneous nodules with cutaneous ulcer and digital gangrene. The skin biopsy showed leukocytoclastic vasculitis with fibrinoid necrosis in the dermal vessels. She received treatment with steroids and lesions resolved completely over a period of month.

  10. Cutaneous Leishmaniasis with HIV.

    Science.gov (United States)

    Talat, Humaira; Attarwala, Sharmeen; Saleem, Mubasshir

    2014-05-01

    Cutaneous Leishmaniasis (CL) is a vector borne disease caused by various species of the Leishmania parasite. CL is endemic in the province of Balochistan in Pakistan. In certain instances a Human Immunodeficiency Virus (HIV)-related immunocompromised is associated with atypical clinical presentation and occurrence of reactivated lesions of CL. Such presentations respond poorly to the standard treatment and frequent relapses are noted. We are reporting three cases of localized and disseminated CL due to Leishmania tropica which responded to meglumine antimoniate. Due to the fact that CL is endemic in Balochistan, we did not consider HIV infection as a causative organism. It was their presentation with history of weight loss and fever that prompted Enzyme-linked Immunosorbent Assay (ELISA) tests for HIV, which turned out to be positive. CL is becoming visible as an opportunistic infection associated with HIV/AIDS and may even be the first symptom in HIV positive patients in an endemic area.

  11. Cutaneous larva migrans

    Directory of Open Access Journals (Sweden)

    Aleksandra Wieczorek

    2016-09-01

    Full Text Available Introduction . Cutaneous larva migrans (CLM is a tropical zoonosis, caused by parasites, usually Ancylostoma braziliense. Humans are an accidental host. Polish patients with CLM are usually tourists visiting tropical and subtropical countries. The first symptoms do not always appear as creeping eruptions, which complicates the diagnosis. Objective. To present the case of a man with CLM after returning from Thailand to Poland and associated diagnostic difficulties. Case report. We present a case of a 28-year-old man who returned to Poland from Thailand. The first symptoms appeared as disseminated pruritic papules. No improvement after treatment with corticosteroids and antihistamines was observed. The diagnosis was established after the appearance of serpentine erythemas and improvement after albendazole therapy. Conclusions. In the case of returnees from exotic countries suffering from raised, pruritic rashes, and no improvement after treatment with corticosteroids and antihistamines, parasitic etiology should be considered.

  12. Radiotherapy of cutaneous lymphomas; Radiotherapie des lymphomes cutanes

    Energy Technology Data Exchange (ETDEWEB)

    Kirova, Y.M.; Piedbois, Y.; Pan, Q.; Guo, J.P.; Le Bourgeois, J.P. [Hopital Henri-Mondor, 94 - Creteil (France). Dept. de cancerologie

    1999-03-01

    Radiotherapy plays an important role in the treatment of cutaneous lymphomas. In the treatment of Mycosis fungoides, total skin electron beam radiation therapy is efficient for patients with limited and superficial forms of the disease. Radiotherapy is also efficient for the locally advanced forms of non-epidermo-tropic lymphomas. The palliative radiotherapy is indicated for advanced, nodular and treatment resistant forms of cutaneous lymphomas and for voluminous lymphadenopathies. (authors)

  13. Recurrent cutaneous leishmaniasis Leishmaniose recidiva cútis

    Directory of Open Access Journals (Sweden)

    Ciro Martins Gomes

    2013-06-01

    Full Text Available We present a case of an 18-year-old male patient who, after two years of inappropriate treatment for cutaneous leishmaniasis, began to show nodules arising at the edges of the former healing scar. He was immune competent and denied any trauma. The diagnosis of recurrent cutaneous leishmaniasis was made following positive culture of aspirate samples. The patient was treated with N-methylglucamine associated with pentoxifylline for 30 days. Similar cases require special attention mainly because of the challenges imposed by treatment.Paciente do sexo masculino, 18 anos. Dois anos após tratamento insuficiente para leishmaniose tegumentar americana, apresentou, na mesma localização, lesão formada por cicatriz atrófica central e nódulos verrucosos na periferia. Era imunocompetente, hígido e negava qualquer trauma local. O diagnóstico de leishmaniose recidiva cutis foi feito através de cultura do aspirado da lesão. Realizou tratamento com N-metilglucamina (20mgSbV/kg/dia associado à pentoxifilina (1200mg/dia durante 30 dias alcançando cura clínica. Os casos semelhantes requerem atenção diferenciada pela dificuldade ao tratamento.

  14. Artaud et les Tarahumaras

    Directory of Open Access Journals (Sweden)

    Marta Mariasole Raimondi

    2008-01-01

    Full Text Available Ce film propose des scènes de vie des Tarahumaras, une ethnie originaire du Mexique installée dans le territoire de l'Etat de Chiuahua, dans un milieu montagneux très sauvage. La caméra reprend les danses et les rites de ces mangeurs de peyotl d'un regard rapide et saccadé primant des cadrages de détail où prédominent les pieds, pour nous montrer ces corps d'homme et de femme en mouvement, courant, dansant, bondissant au milieu des leurs éléments naturels : rocailles, rivières, rochers, sans...

  15. Les quartiers de Zabid

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    Paul Bonnenfant

    1999-08-01

    Full Text Available Je voudrais présenter ici des notes concernant les quartiers de Zabîd, ville située dans la plaine côtière de la Tihâma, à une centaine de kilomètres au sud-est d'al-Hudayda. Elles ont été rassemblées au cours d'une étude portant sur l'architecture domestique de Zabîd, dont les résultats seront publiés dans un livre ultérieur. J'ai étudié la genèse d'habitations exceptionnelles qui, avec les monuments religieux et militaires, ont valu à Zabîd d'être classée sur la liste du Patrimoine mondial ...

  16. LES INFECTIONS NOSOCOMIALES NEONATALEj

    OpenAIRE

    BELHOCINE, Meryem; BELGAID, Hanane

    2013-01-01

    introduction: Les infections nosocomiales représentent un réel problème dans les unités de néonatologie. Elles ont vu leur incidence croitre en raison de l'extension des procédures invasives de diagnostics et thérapeutiques. Objectif: déterminer l'épidémiologie des infections nosocomiales dans le sente de néonatologie a i'EHS Mère-Enfant de Tlemcen. Matériel et méthodes: Il s'agissait d'une étude rétrospective de type cas —témoin incluant tous les nouveau-nés admis en 2011 e...

  17. LES INFECTIONS NOSOCOMIALES NEONATALEj

    OpenAIRE

    BELHOCINE, Meryem; BELGAID, Hanane

    2013-01-01

    introduction: Les infections nosocomiales représentent un réel problème dans les unités de néonatologie. Elles ont vu leur incidence croitre en raison de l'extension des procédures invasives de diagnostics et thérapeutiques. Objectif: déterminer l'épidémiologie des infections nosocomiales dans le sente de néonatologie a i'EHS Mère-Enfant de Tlemcen. Matériel et méthodes: Il s'agissait d'une étude rétrospective de type cas —témoin incluant tous les nouveau-nés admis en 2011 e...

  18. Cutaneous hamartoma with pagetoid cells.

    Science.gov (United States)

    Piérard-Franchimont, C; Dosal, F L; Estrada, J A; Piérard, G E

    1991-04-01

    We report an unusual cutaneous hamartoma with pagetoid cells characterized by the presence of intraepidermal cells resembling Toker's cells of the nipple. These cells were EMA positive and could be related to the histogenesis of some Paget's disease.

  19. [Ocular metastasis of cutaneous melanoma].

    Science.gov (United States)

    Galland, F; Balansard, B; Conrath, J; Forzano, O; Ridings, B

    2004-02-01

    We report a case of vitreal metastases from cutaneous melanoma. We describe the clinical findings and the histological aspects of the lesions, which allows us to discuss the diagnosis of masquerade syndrome and highlight the diagnostic importance of vitreous biopsy.

  20. Cutaneous actinomycosis: A rare case

    Directory of Open Access Journals (Sweden)

    Metgud S

    2007-01-01

    Full Text Available Cutaneous actinomycosis is a rare presentation. Here we present a case of cutaneous actinomycosis with no history of trauma or systemic dissemination. The isolate was identified as Actinomyces viscosus by standard methods. The isolate was found to be penicillin resistant by Kirby Bauer disc diffusion method. Therefore, the patient was treated with cotrimoxazole and improved. Thus, this case highlights the importance of isolation and susceptibility testing in actinomycotic infection. The sinuses have healed, and the patient has recovered.

  1. Systemic diseases with cutaneous manifestations.

    Science.gov (United States)

    Merchant, S R; Taboada, J

    1995-07-01

    The purpose of this article is to briefly discuss the following cutaneous manifestations of selected systemic diseases: poxvirus; feline leukemia virus (FeLV); feline immunodeficiency virus (FIV); herpesvirus; calcivirus; pseudorabies; plague; tularemia; toxoplasmosis; leishmania; hypothyroidism; hyperthyroidism; hyperadrenocorticism; diabetes mellitus; acromegaly; thallium poisoning; pancreatic disease; hypereosinophilic syndrome; mucopolysaccharidosis; and pansteatitis. Recognition of these cutaneous signs may help alert the clinician to the possibility of an internal disorder so that the appropriate diagnostic tests can be considered.

  2. Reboiser sous les tropiques

    Directory of Open Access Journals (Sweden)

    Pierlot, R.

    2007-01-01

    Full Text Available To Reafforest in the Tropics. Le sanctuaire de gorilles de Lossi constitue une expérience sur la synergie entre la recherche scientifique et la conservation de la nature. Trois parties prenantes sont impliquées dans un processus de gestion participative: l'Etat congolais, la communauté autochtone représentée par l'association des ayants droits des terres de Lossi et le programme européen sur les écosystèmes forestiers d'Afrique centrale. Une enquête de terrain a été effectuée sur le site de Lossi en 2003; elle avait comme objectif d'étudier les effets générés par la gestion participative et d'identifier les contraintes liées à l'exécution de cette approche participative en milieu réel. Les travaux de recherche sur la primatologie ont abouti à l'habituation des gorilles à la présence humaine, ce qui a conduit à la création d'un tourisme de vision de gorilles de plaine de l'Ouest. Un camp de touristes a été construit, ainsi que l'ouverture de la route d'accès au sanctuaire. Le tourisme a généré des emplois en faveur de la population locale qui est aussi prestataire de contrats sur les travaux de réfection des routes. Une partie des revenus a permis la construction d'un centre de santé intégré. Cependant, les travaux de recherche scientifique et le tourisme ont été ralentis pendant l'apparition de la fièvre hémorragique d'Ebola et pendant les trois épisodes de la guerre civile. La consolidation et le long terme de cette entreprise de cogestion du patrimoine naturel de Lossi consiste en l'établissement d'un plan d'aménagement et de gestion, qui concilie la conservation, le développement rural et la recherche scientifique tout en garantissant une répartition équitable des revenus entre les trois partenaires.

  3. Métastases cutanées vues au laboratoire d'anatomie pathologique à Lomé, Togo entre 2005 et 2014

    Science.gov (United States)

    Darre, Tchin; Saka, Bayaki; Landoh, Dadja Essoya; Mouhari-Toure, Abas; Amegbor, Koffi; Pitché, Palokinam; Napo-Koura, Gado

    2015-01-01

    Introduction L'objectif de cette étude était de documenter le profil épidémiologique et histologique des métastases cutanées vues au laboratoire d'anatomie pathologique (LAP) de Lomé. Méthodes Il s'agissait d'une étude descriptive et transversale portant sur des cas de métastases cutanées observées au LAP du CHU Sylvanus Olympio entre 2005 et 2014. Résultats Au cours de cette période d’étude, nous avons recensé 32 cas de métastases cutanées représentant 3,2% (1005 cas) de l'ensemble des cas de métastases enregistrées au LAP. L’âge moyen des patients atteints de ces métastases cutanées était de 42,6 ans et le sex-ratio (F/H) de 2,2. Sur le plan macroscopique, ces métastases étaient nodulaires dans 15 cas, bourgeonnantes dans 12 cas, ulcéré dans 3 cas et ulcéro-bourgeonnant dans 2 cas. Les types histologiques étaient représentés par les adénocarcinomes (19 cas, 59,4%), les carcinomes épidermoïdes (8 cas, 25%), la maladie de Paget (3 cas, 9,4%), le carcinome à petites cellules du type neuroendocrine (un cas, 3,1%) et le mélanome (un cas, 3,1%). Selon le degré de différenciation, les métastases cutanées étaient bien différenciées dans 14 cas (56%). Les principales localisations de ces métastases cutanées étaient le thorax (11 cas, 34,4%) suivi de l'abdomen (10 cas, 31,3%). Les cancers primitifs étaient surtout d'origine mammaire (14 cas, 43,7%). Conclusion Cette étude montre que les métastases cutanées sont relativement rares et les tumeurs malignes d'origine mammaire sont les tumeurs primitives prédominantes. Avec un pourcentage élevé des formes peu différenciées et celles indifférenciées, l'amélioration du plateau technique du LAP (immunohistochimie) permettra d'accroitre ses capacités diagnostiques. PMID:27047627

  4. Les nerfs à fleur de peau.

    Science.gov (United States)

    Misery, L

    2002-04-01

    Skin innervation is extremely dense and reaches the most superficial layers of the epidermis (but not into the stratum corneum). The relationship between skin and the nervous system was neglected for a long time. Nowadays, this represents one of the most widely investigated fields of skin biology. Associations between nerve fibres and skin are so close that these can be observed at the cellular level. They are anatomical and physiological. Neurotransmitters are naturally synthesized by nerve endings, but cells from the skin and the immune system are also able to produce them. They are mediators for transmission of information between skin and the nervous system. All cutaneous and immune cells express specific receptors for these neuromediators, and enzymes for degrading them. Binding of the neurotransmitter to its receptor induces modulation of cell properties and skin functions (immunity, cell differentiation and proliferation, pigmentation, etc.). Hence, keratinocytes, Langerhans cells, melanocytes, endothelial cells, fibroblasts and the other cells of the skin or the immune system are modulated and controlled by the nerves. Reciprocally, skin is able to modulate neuronal activity and growth. All these data suggest that skin, nervous and immune systems are integrated in a unique system that we could name the neuro-immuno-cutaneous system (NICS). Hence, we can understand how the nervous system, and further the psychism, are involved in the maintenance of cutaneous homeostasis. In dermatological diseases or in cosmetological disorders, this equilibrium is broken. New fields of research are open: neuro-dermatology and of course neuro-cosmetics. Neuro-cosmetic products are supposed to modulate NICS functioning at the epidermal level. The French expression 'avoir les nerfs à fleur de peau' means that nervosity is so tense that one feels his nerves closely under or within skin, ready to explode. In fact, nerves are always 'à fleur de peau'. Skin is an organ whose

  5. Les Cahiers du CREAD

    African Journals Online (AJOL)

    Admin

    C'est dans un climat de crise économique où les pouvoirs publics perdent la capacité de ... d'offres d'emploi et permettre aux usagers d'accéder aux ressources offertes par la ville, ...... «Croissance urbaine, mobilité et transport urbain.

  6. Notes sur les Limaces

    NARCIS (Netherlands)

    Regteren, van C.O.

    1964-01-01

    9. DESCRIPTION D'UNE NOUVELLE ESPÈ CE DE DEROCERAS DES ENVIRONS DE GRENADE 1) Même pour celui qui ne dispose pas d'une voiture, la ville de Grenade est un magnifique centre d'excursions. Les trams et autobus permettent au naturaliste de sortir de la ville en toutes directions et de commencer ses pro

  7. Les formes du fond

    Directory of Open Access Journals (Sweden)

    Michel Maffesoli

    2004-12-01

    Full Text Available Il n'est pas vrai que la nature a horreur du vide. Peut-être même s'y complait-elle. Le creux est aussi une modalité de l'être. Il est possible de s'y nicher, de s'y lover paresseusement et, ainsi, de se protéger contre l'angoisse du temps qui passe. Le creux des apparences est, à certains moments, une des formes d'expression de la vie sociale. Encore faut-il savoir le reconnaître. Certes, nous avons tous une existence personnelle, mais nous sommes, également, les représentants, parfois même les victimes, d'un "esprit commun", peut-être même d'un "inconscient collectif" qui s'est constitué de siècle en siècle. Et, très souvent, là où nous croyons exprimer nos propres idées, nous ne sommes que les porte-voix, les figurants d'un vaste "theatrum mundi" aux dimensions infinies.

  8. Notes sur les Limaces

    NARCIS (Netherlands)

    Regteren, van C.O.

    1964-01-01

    9. DESCRIPTION D'UNE NOUVELLE ESPÈ CE DE DEROCERAS DES ENVIRONS DE GRENADE 1) Même pour celui qui ne dispose pas d'une voiture, la ville de Grenade est un magnifique centre d'excursions. Les trams et autobus permettent au naturaliste de sortir de la ville en toutes directions et de commencer ses

  9. Genotyping of cutaneous melanoma.

    Science.gov (United States)

    Glitza, Isabella C; Davies, Michael A

    2014-09-01

    Until recently, treatment options for patients with metastatic melanoma were very limited. This landscape has evolved dramatically since the discovery of activating mutations in the BRAF gene in ~45% of cutaneous melanomas. Vemurafenib, dabrafenib, and trametinib have all received regulatory approval for the treatment of metastatic melanoma patients with a BRAF(V600) mutation. Based on the necessity to document the presence of a BRAF(V600) mutation to prescribe these agents, molecular testing is now the standard of care in this disease. However, the options and rationale for testing are evolving rapidly due to an improved understanding of the molecular drivers and heterogeneity of melanoma. Such testing may identify rational combinatorial approaches to prevent or overcome resistance for the approved BRAF inhibitors. In addition, new clinical strategies have been identified for a number of other molecular changes that are detected in this disease, including somatic changes in NRAS, PTEN, CDKN2A, and c-KIT, among others. This review summarizes the current understanding of the genetic landscape of mutations in melanoma, their associations with clinicopathological features, and their implications for clinical testing and treatment.

  10. Alopecia: manifestação cutânea rara de sarcoidose Alopecia: an uncommon cutaneous manifestation of sarcoidosis

    Directory of Open Access Journals (Sweden)

    Fabiane Mulinari Brenner

    2008-10-01

    Full Text Available A sarcoidose é doença granulomatosa multissistêmica que geralmente compromete o trato respiratório e os linfonodos hilares. A pele é comumente afetada, mas raramente o couro cabeludo. Dois casos de sarcoidose com lesões no couro cabeludo são relatados: o primeiro, em paciente negra apresentando áreas de alopecia no couro cabeludo associada a outras lesões cutâneas; e o segundo, em paciente branca, portadora de sarcoidose pulmonar, com alopecia como manifestação cutânea isolada. A sarcoidose de couro cabeludo merece especial atenção, pois nos pacientes com essa forma de lesão cutânea existe alta incidência de acometimento sistêmico.Sarcoidosis is a multi-system granulomatous disease that generally affects the respiratory tract and hilar lymph nodes. The skin is also commonly involved, although cutaneous sarcoidosis on the scalp is rare. Two cases of scalp sarcoidosis are reported: the first presented with patchy alopecia, cutaneous sarcoidosis and also systemic disease in a black patient; the second case is related to an uncommon presentation with alopecia as the single cutaneous manifestation in a Caucasian patient with pulmonary sarcoidosis. Scalp sarcoidosis deserves special attention because there is a high incidence of other systemic lesions with this cutaneous manifestation, thus a careful investigation should be performed in these patients.

  11. Les barrages alpins

    Directory of Open Access Journals (Sweden)

    Alain Marnezy

    2009-03-01

    Full Text Available Les barrages-réservoirs de montagne ont été réalisés initialement dans les Alpes pour répondre à la demande d’énergie en période hivernale. Une certaine diversification des usages de l’eau s’est ensuite progressivement développée, en relation avec le développement touristique des collectivités locales. Aujourd’hui, la participation des ouvrages d’Électricité De France à la production de neige de culture représente une nouvelle étape. Dans les régions où les aménagements hydroélectriques sont nombreux, les besoins en eau pour la production de neige peuvent être résolus par prélèvements à partir des adductions EDF. Les gestionnaires de stations échappent ainsi aux inconvénients liés à la construction et à la gestion des « retenues collinaires ». Cette évolution, qui concerne déjà quelques régions alpines comme la haute Maurienne ou le Beaufortin, apparaît comme une forme renouvelée d’intégration territoriale de la ressource en eau.Mountain reservoirs were initially built in the Alps to meet energy needs in the winter. A certain diversification in the uses of water then gradually developed, related to tourism development in the local communities. Today, the use of facilities belonging to EDF (French Electricity Authority to provide water for winter resorts to make artificial snow represents a new phase. By taking water from EDF resources to supply snow-making equipment, resort managers are thus able to avoid the problems related to the construction and management of small headwater dams. This new orientation in the use of mountain water resources already affects a number of alpine regions such as the Upper Maurienne valley and Beaufortain massif and represents a renewed form of the territorial integration of water resources.

  12. Onychomadesis Following Cutaneous Vasculitis.

    Science.gov (United States)

    Damevska, Katerina; Gocev, Gorgi; Pollozahani, Nora; Nikolovska, Suzana; Neloska, Lence

    2017-04-01

    Beau lines are transverse, band-like depressions extending from one lateral edge of the nail to the other and affecting all nails at corresponding levels (1). Onychomadesis is considered an extreme form of Beau line with subsequent separation of the proximal nail plate from the nail bed. Both fall along a spectrum of nail plate abnormalities that occur secondary to temporary nail matrix arrest (NMA). Various systemic and dermatologic conditions have been reported in association with onychomadesis (2-7) (Table 1). Nail changes can affect all or some of the nails and both the fingernails and toenails; however, fingernails are more frequently affected. The severity of the nail changes varies depending on the underlying cause, its duration, and environmental factors (8). We present a case of onychomadesis following cutaneous leukocytoclastic vasculitis (CLCV). A 61-year-old woman presented to the Dermatology Clinic complaining of a purpuric rash that began on her lower extremities and rapidly progressed to her abdomen and upper extremities over the previous five days. Her medical history was remarkable for hypertension and diet-controlled diabetes mellitus. Her medications included enalapril, which she had been taking for the past four years. On three consecutive days before the skin eruption, the patient took oral diclofenac sodium for hip pain. A clinical examination revealed non-blanching petechial rash on the legs, abdomen, and upper limbs up to the elbow (Figure 1, A) with leukocytoclastic vasculitis on biopsy (Figure 1, B). Direct immunofluorescence was negative. Laboratory investigations revealed a white blood cell count of 14.5 × 109/L with a normal differential count, and a platelet count of 380 × 109/L. Westergren erythrocyte sedimentation rate was 65 mm/1st h, and C reactive protein was at 8.5 mg/dL. Antinuclear antibodies, rheumatoid factor, immune complexes, and cryoglobulinemia were negative, as were B and C hepatitis virus serological tests. Her renal

  13. LES APPROCHES PSYCHOSOCIOLOGIQUES DES ORGANISATIONS

    Directory of Open Access Journals (Sweden)

    Deaconu Alecxandrina

    2008-05-01

    Full Text Available Les préoccupations pour bien comprendre la complexité des organisations sont bien connues dans la théorie et la pratique du management. La motivation la plus fréquente pour toutes les recherches et les investigationes faites a été fondée sur le besoin de savoir gérer les situations diverses en vue de maximiser la performance organisationnelle. En ce qui nous concerne, pour enrichir les informations disponibles, nous voulons élargir, dans notre communication, les approches traditionelles, focaliser l’attention sur la dimension psychologiques des organisations et présenter les mécanismes qui favorisent l’implication des salariés.

  14. Aspects of cutaneous ageing.

    Science.gov (United States)

    Dalziel, K L

    1991-09-01

    'Ageing is a multistep, multifaceted, time-dependent phenomenon characterized by the decreased ability of a system to respond to exogenous and endogenous stress from either physical, chemical or biologic agents'. Cutaneous ageing provides a visible model of the interaction between endogenous (intrinsic) factors and exogenous (extrinsic) factors. In skin, the principal extrinsic-factor is ultraviolet light (UV) which is responsible for the constellation of changes termed photoageing. In recent years, much interest has been directed towards defining the ageing processes in skin and excellent comprehensive reviews have been compiled. This review aims to highlight several areas of developing knowledge, and focuses on the potential importance of environmental changes as they influence skin ageing and carcinogenesis. Repeated reference to the effects of UV on the skin are inevitable in any review of skin ageing and this is scarcely surprising as the skin contains many cells as well as subcellular and extracellular chromophores which are capable of absorbing energy within the UV spectrum. Cellular chromophores include among others keratinocytes, melanocytes, Langerhans cells, dermal fibroblasts and mast cells. Subcellular chromophores include keratin, melanin, collagen, elastin and a number of proteins, lipids and steroids (such as vitamin D). Urocanic acid, a photoisomerization product of the amino-acid histidine, may provide some limited photoprotection and some believe it to be important in UV induced immunosuppression. Understanding events at the molecular and biochemical level has unfortunately not been paralleled by clinical advances and the common, troublesome skin-problems of old age such as cancer, xerosis and pruritus remain a major cause of morbidity and yet are poorly explained.

  15. Whole-body staging of malignant melanoma. Advantages, limitations and current importance of PET-CT, whole-body MRI and PET-MRI; Ganzkoerperdiagnostik beim malignen Melanom. Vorteile, Grenzen und aktueller Stellenwert von PET-CT, GK-MRT und PET-MRT

    Energy Technology Data Exchange (ETDEWEB)

    Pfannenberg, C.; Schwenzer, N. [Eberhard-Karls-Universitaet Tuebingen, Abteilung Diagnostische und Interventionelle Radiologie, Tuebingen (Germany)

    2015-01-16

    Cross-sectional imaging methods are currently the standard methods for staging of advanced melanoma. The former time-consuming and expensive multimodality approach is increasingly being replaced by novel whole-body (WB) staging methods, such as 18F-fluorodeoxyglucose positron emission tomography/computed tomography ({sup 18}F-FDG-PET-CT) and whole-body magnetic resonance imaging (WBMRI) because they offer a complete head-to-toe coverage of the patient in a single examination with an accurate and sensitive detection of tumor spread. Several studies in patients with advanced melanoma revealed that PET-CT is more sensitive and specific than conventional modalities, such as CT alone resulting in a change of management in up to 30 % of cases. Due to the limited sensitivity of PET for lesions smaller than 1 cm, PET-CT is not useful for the initial work-up of patients with stage I and II melanoma but has proven to be superior for detection of distant metastases, which is essential prior to surgical metastasectomy. If PET-CT is not available WB-CT or WB-MRI can alternatively be used and WB-MRI including diffusion-weighted imaging (DWI) has become a real alternative for staging of melanoma patients. So far, however, only few reports suffering from small numbers of cases and heterogeneous design have compared the diagnostic performance of WB-MRI and PET-CT. The preliminary results indicate a high overall diagnostic accuracy of both methods; however, these methods differ in organ-based detection rates: PET-CT was more accurate in N-staging and detection of lung and soft tissue metastases whereas WB-MRI was superior in detecting liver, bone and brain metastases. The value of PET-MRI for staging of advanced melanoma is the subject of ongoing clinical studies. (orig.) [German] Schnittbildmethoden sind heute der Standard bei der Ausbreitungsdiagnostik ab Stadium III des malignen Melanoms. Das fruehere zeit- und kostenaufwendige multimodale Konzept wird heute durch Ganzkoerper

  16. Cyrano et les hydropotes

    Directory of Open Access Journals (Sweden)

    Alain Mothu

    2007-10-01

    Full Text Available « Car il sera grand devant le Seigneur. Il ne boira ni vin, ni liqueur enivrante, et il sera rempli de l’Esprit-Saint dès le sein de sa mère »(Luc, I, 15Cyrano dédie sa lettre à la gloire de l’aqueduc d’Arcueil et des fontaines parisiennes qu’il alimentait, à « (ses amis les buveurs d’eau ». Cette dédicace abrite peut-être une fine allusion au fait que la construction de l’« acqueduc Médicis », entamée en 1612, fut financée en partie par un droit d’entrée à Paris imposé sur les vins, comme ...

  17. Faire voter les morts

    Directory of Open Access Journals (Sweden)

    Boris Jeanne

    2008-04-01

    Full Text Available Le film de zombie a toujours été politique. Marxiste même, associant dans une lecture rapide du Capital les morts-vivants et le Lumpenproletariat, et s’en prenant vivement à la société de consommation, que ce soit chez les fondateurs (George Romero ou leurs épigones (L’armée des morts de Zack Snyder se passe dans un centre commercial. En contexte post-11 septembre, ce sont Bush et Fox News qui en deviennent la cible, et le film de zombie réalisé par Joe Dante pour la première saison de la ...

  18. Cutaneous Plasmacytosis with Perineural Involvement

    Directory of Open Access Journals (Sweden)

    Elizabeth A. Brezinski

    2014-01-01

    Full Text Available Importance. Cutaneous and systemic plasmacytosis are rare conditions of unknown etiology with characteristic red-brown skin lesions and a mature polyclonal plasma cell infiltrate within the dermis. Perineural plasma cell infiltrates may be a histologic clue to the diagnosis of cutaneous plasmacytosis. Observations. Our patient had a five-year history of persistent reddish-brown plaques on the neck and trunk without systemic symptoms. Histologic examination showed dermal perivascular and perineural plasma cells with excess lambda light chain expression. Due to decreased quality of life caused by his skin lesions, he was placed on a chemotherapeutic regimen with bortezomib. Conclusions and Relevance. The patient was diagnosed with cutaneous plasmacytosis based on classic histopathology results with a recently characterized pattern of perineural involvement. Bortezomib therapy was initiated to manage his skin eruption, which has not been previously described as a treatment for this chronic condition.

  19. Les Tinamous. Tinami

    NARCIS (Netherlands)

    Schlegel, H.

    1880-01-01

    Les Tinamous forment une tribu d’oiseaux parfaitement isolée et circonscrite, et bornée à la partie de l’Amérique comprise entre le Mexico méridional et la Patagonie. Ils se rattachent, toutefois, naturellement à l’ordre des Gallinae, tout en offrant certaines affinités avec l’ordre des Autruches. I

  20. Les urgences infectieuses ORL

    Science.gov (United States)

    Sereme, Moustapha; Tarnagda, Souleymane; Guiguimde, Patrice; Gyebre, Yvette Marie Chantal; Ouedraogo, Bertin; Céline, Bambara; Ouattara, Maimouna; Ouoba, Kampadilemba

    2016-01-01

    Affections gravissimes à pronostic très réservé particulièrement dans notre contexte de sous médicalisation et de pauvreté. Notre but en initiant ce travail est de déterminer les étiologies de ces urgences et discuter de leur prise en charge thérapeutique. Étude de type rétrospective et descriptive sur 05 ans, au total 52 dossiers cliniques ont été inclus. Ces infections ont représenté 0,33% de nos consultations. La moyenne d'âge de nos patients a été 23 ans. Le jeune âge, les traitements inappropriés et certaines affections ORL ont été retrouvés comme facteurs favorisants. Les motifs de consultation ont été variés en fonction du siège de l'infection, cependant deux signes cliniques ont été constants: la douleur et la fièvre. L'adénophlegmon, le phlegmon péri-amygdalien, les cellulites ont été nos principales étiologies avec le streptocoque et le staphylocoque comme principaux germes en cause. L'antibiothérapie probabiliste a été utilisée en première intention notamment l'association céphalosporine de 3ème génération + aminoside + imidazolé. L'évolution clinique de nos patients a été marquée par la survenue de complications locales et générales. Urgence diagnostic et thérapeutique leur évolution reste encore émaillée de complication en raison de la consultation tardive de nos patients. PMID:28154719

  1. Les Cahiers du CREAD

    African Journals Online (AJOL)

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    l'apprentissage implicite ou explicite qui fonctionne comme un système de schèmes générateurs, est générateur de stratégie qui peuvent être objectivement conformes ..... passe mais il a une idée de toutes les nouvelles technologies utilisées, de ..... ction dans une situation de dépendance épistémique, de problème.

  2. Les tactiques de Chronos

    CERN Document Server

    Klein, Etienne

    2009-01-01

    Nous ne doutons pas de l'existence du temps, qui demeure pourtant un objet introuvable. Nous voyons, entendons, goûtons, touchons dans le temps, mais non le temps lui-même. Il concerne toute chose, contraint tout, mais de quelle façon ? Est-il apparu en même temps que l'univers ou l'a t-il précédé ? Est-il dans le monde ou le contient-il ? S'écoule-t-il en sens unique ? Serait-ce la mort qui nous obligerait à penser le temps ? Au XXe siècle, la physique a bouleversé notre conception du temps et en vient à effleurer des questions jusque la façon dont l'homme choisit de vivre et de se vivre. Quelles sont les convergences et les différence entre le temps physique et le temps sensible, existentiel ? Pour éclairer les paradoxes, répondre aux questions, Etienne Klein puise, en contrepoint de la physique, dans la philosophie, la psychologie, la littérature, ma poésie... et le sport.

  3. Les pirogues du Maroni

    Directory of Open Access Journals (Sweden)

    Sophie François

    2012-04-01

    Full Text Available Sur le Maroni, fleuve frontière entre la Guyane française et le Surinam, les pirogues amarrées le long des berges se comptent par centaines. Elles représentent le seul moyen de transport pour les milliers de personnes vivant sur les rives du Maroni. Les différentes formes de pirogues sont révélatrices de la diversité géographique du Maroni et de la diversité culturelle des populations. Les Amérindiens du littoral naviguent uniquement dans l’estuaire du fleuve. Ils construisent des pirogues larges, hautes et terminées à la poupe par une haute étrave qui fend les vagues. Ces pirogues sont construites à partir d’une coque monoxyle expansée et rehaussée d’un ou de deux bordages. En chauffant la grume évidée, le bois acquiert une certaine plasticité qui permet d’écarter les flancs et d’obtenir une coque très large à partir d’un arbre de faible diamètre. Les Bushinenge, populations d’origine africaine qui ont déserté les grandes plantations de la Guyane hollandaise dès le début du XVIIe siècle et se sont installées sur les deux rives du Maroni, ont développé des formes de pirogues adaptées au passage des sauts. Leurs pirogues, construites également en expansant la coque au feu, sont étroites et longues et possèdent des extrémités curvilignes qui dépassent largement au–dessus du bordage. Les longues pirogues à moteur comme les canots–pagaies sont ornés de motifs d’entrelacs appelés tembé ; et de décors d’inspiration contemporaine. L’inventaire des pirogues du Maroni a mis en évidence la richesse et la vitalité du patrimoine nautique de cette région au début du XXIe siècle, tant au niveau des formes des embarcations que des décors et des pratiques de navigation.On the Maroni river, natural border between French Guyana and the Surinam, canoes tied to the river banks can be counted by the hundreds. They are the only mean of transportation for thousands of people living along the

  4. "Pure" cutaneous histiocytosis-X.

    Science.gov (United States)

    Wolfson, S L; Botero, F; Hurwitz, S; Pearson, H A

    1981-11-15

    The case histories of two young children who experienced skin rashes involving various areas of the body are reported. The diagnosis of pure cutaneous histiocytosis-X was established after extensive studies revealed no other organ involvement. The patients were treated with oral corticosteroids. Currently, both children are in good health, show no evidence of disease, and have been followed over a four-to-five-year period. Therapy with corticosteroids may not be indicated with pure cutaneous histiocytosis-X unless there is evidence of extracutaneous dissemination or rapid progression of the disease.

  5. MELDOQ - astrophysical image and pattern analysis in medicine: early recognition of malignant melanomas of the skin by digital image analysis. Final report; MELDOQ - Astrophysikalische Bild- und Musteranalysen in der Medizin: Frueherkennung des malignen Melanoms der Haut mit Hilfe digitaler Bildverarbeitung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Bunk, W.; Pompl, R.; Morfill, G.; Stolz, W.; Abmayr, W.

    1999-07-01

    Dermatoscopy is at present the most powerful clinical method for early detection of malignant melanomas. However, the application requires a lot of expertise and experience. Therefore, a quantitative image analysis system has been developed in order to assist dermatologists in 'on site diagnosis' and to improve the detection efficiency. Based on a very extensive dataset of dermatoscopic images, recorded in a standardized manner, a number of features for quantitative characterization of complex patterns in melanocytic skin lesions has been developed. The derived classifier improved the detection rate of malignant and benign melanocytic lesions to over 90% (sensitivity =91.5% and specificity =93.4% in the test set), using only six measures. A distinguishing feature of the system is the visualization of the quantified characteristics that are based on the dermatoscopic ABCD-rule. The developed prototype of a dermatoscopic workplace consists of defined procedures for standardized image acquisition and documentation, components of a necessary data pre-processing (e.g. shading- and colour-correction, removal of artefacts), quantification algorithms (evaluating asymmetry properties, border characteristics, the content of colours and structural components) and classification routines. In 2000 an industrial partner will begin marketing the digital imaging system including the specialized software for the early detection of skin cancer, which is suitable for clinicians and practitioners. The primary used nonlinear analysis techniques (e.g. scaling index method and others) can identify and characterize complex patterns in images and have a diagnostic potential in many other applications. (orig.) [German] Die Dermatoskopie stellt die derzeit leistungsfaehigste klinische Methode zur Frueherkennung des malignen Melanoms dar. Da deren erfolgreiche Anwendung viel Expertenwissen voraussetzt, wurde im Rahmen des MELDOQ-Projektes ein quantitatives Bildanalysesystem

  6. Cutaneous cancer and xeroderma pigmentosum; Cancer cutane et xeroderma pigmentosum

    Energy Technology Data Exchange (ETDEWEB)

    Ben Salah, H.; Bahri, M.; Mnejja, W.; Siala, W.; Daoud, J. [Centre Hospitalier Universitaire Habib-Bourguiba, Service de Radiotherapie Carcinologique, Sfax (Tunisia); Sallemi, T. [Centre Hospitalier Universitaire Habib-Bourguiba, Service d' Anatomie Pathologique, Sfax (Tunisia); Turki, H. [Centre Hospitalier Universitaire Habib-Bourguiba, Service de Dermatologie, Sfax (Tunisia)

    2007-11-15

    The cutaneous cancer at the patients affected by xeroderma pigmentosum is characterized by its multifocal character and its strong radiosensitivity. A premature care and a regular follow-up for life of these patients is indispensable for the detection and the treatment of new hurts. The precautionary measures are also important by the school eviction. (N.C.)

  7. Les alfabetitzacions digitals

    Directory of Open Access Journals (Sweden)

    José Luis Rodríguez Illera

    2005-01-01

    Full Text Available En este artículo se analiza el concepto de alfabetizaciones digitales, enfatizando los cambios en la idea de alfabetización y los efectos sobre las denominadas «nuevas alfabetizaciones». Se proponen los ejes principales para analizarlo, considerando con más detalle lo que suponen las nuevas prácticas de escritura en el caso de la multimedialidad. Finalmente, se apunta que las alfabetizaciones digitales requieren ser tomadas como un campo de investigación educativa y no únicamente como capacitación en el uso de los medios digitales. _____________________________________________________________________________________________________________________________ Cet article analyse le concept d’alphabétisation digitale, en mettant l’accent sur les changements de l’idée même d’alphabétisation ainsi que sur les effets quant aux «nouvelles alphabétisations». Il pose les axes principaux permettant d’analyser ce concept, en envisageant plus en détail ce qu’impliquent les nouvelles pratiques d’écriture dans un environnement multimédia. Enfi n, il insiste sur le fait que les alphabétisations digitales doivent être considérées comme un domaine de recherche et pas seulement comme une capacitation dans l’usage des moyens digitaux.This paper analyses the concept of digital literacies, underlining the changes in the idea of literacy and the effects on the socalled “new literacies”. The main focus points are proposed for the analysis, taking a closer look at what new writing practices suppose in the case of multimediality. Last of all, it is pointed out that digital literacies need to be treated as a fi eld of educational research and not only as an enabling factor in the use of digital media.En este artículo se analiza el concepto de alfabetizaciones digitales, enfatizando los cambios en la idea de alfabetización y los efectos sobre las denominadas «nuevas alfabetizaciones». Se proponen los ejes principales para

  8. Des Orques sous les tropiques

    OpenAIRE

    Sounguet, Guy-Philippe

    2002-01-01

    Les populations de Cétacés qui vivent au Sud et qui atteignent les côtes du Gabon, quittent la région antarctique à la fin de l'été austral. Lorsque la banquise s'étend vers le nord, ils remontent vers les côtes occidentales africaines en empruntant le courant froid antarctique qui les portent jusqu'à l'équateur. Cette migration saisonnière Sud-Nord s'effectue durant l'hiver austral. Les animaux font leur apparition dans les régions équatoriales en juin pour repartir à partir de septembre. Bi...

  9. Cutaneous, mucocutaneous and neurocutaneous cysticercosis

    Directory of Open Access Journals (Sweden)

    Arora P

    1990-01-01

    Full Text Available Cutaneous cysticerci are often a pointer to the involvement of internal organs. A series of 33 patients including 5 vegetarians, between 10 to 48 years age, were investigated. Almost half the patients presented with cutaneous cysts of less than one month duration or were unaware of it. In the, other the duration varied upto 10 years. Cutaneous cysts were present in the case&Mental retardation, diminished vision and flashes of lights were, recorded in one case each, raised intracranial tension in 11 and seizures in 29 patients. Four, of the 6 patients with solitary cysts had no involvement of the internal- organs, whereas all the 27 patients with multiple had in nt of brain. Trunk was the commonest site in 16 patients. The other sites involved were scalp, eyelids, face, tongue neck, breast and limbs. Stool examination -for tapeworm segments/ eggs was positive in 2,calcification was seen on X-ray examination of skull in one and of soft tissues in 3, CT scan of skull was suggestive of cysticerci in 27 and skin biopsy for cysticercosis was confirmatory in all the 33 patients. Four patients with a solitary cutaneous cyst were treated by excision. One patients with neurocutaneous cysts was treated with albendazole without response. Out of 16patients with mucocutaneous and neurocutaneous cysticercosis treated with praziquantel, one did not respond. 7 responded partially and 8 had complete relief.

  10. Ultraviolet light and cutaneous lupus

    NARCIS (Netherlands)

    Bijl, Marc; Kallenberg, Cees G. M.

    2006-01-01

    Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining th

  11. Ultraviolet light and cutaneous lupus

    NARCIS (Netherlands)

    Bijl, Marc; Kallenberg, Cees G. M.

    2006-01-01

    Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining th

  12. Vitiligo associated with cutaneous amyloidosis

    Directory of Open Access Journals (Sweden)

    Rajkumar V

    2001-09-01

    Full Text Available Vitiligo is known to be associated with a variety of dermatoses and systemic diseases. We describe a case of vitiligo developing in a patient having cutaneous amyloidosis. To our knowledge this is the first report of its kind in the literature.

  13. TUBERCULOUS SIALO-CUTANEOUS FISTULA

    Directory of Open Access Journals (Sweden)

    Bapi Lal

    2013-04-01

    Full Text Available ABSTRACT: Tuberculosis of the parotid gland is a rare clinica l entity. We present a case of parotid gland tuberculosis that presented with a sial o-cutaneous fistula. This case was successfully treated with antituberculous drugs onl y without any surgical excision.

  14. Multiple Cutaneous (pre)-Malignancies

    NARCIS (Netherlands)

    R.J.T. van der Leest (Robert)

    2015-01-01

    markdownabstract__Abstract__ The three most common cutaneous malignancies are derived from melanocytes and keratinocytes (ordered in decreasing aggressiveness): melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). This thesis focuses only on these three types of cancer and their

  15. Vacuum enhanced cutaneous biopsy instrument

    Science.gov (United States)

    Collins, Joseph

    2000-01-01

    A syringe-like disposable cutaneous biopsy instrument equipped with a tubular blade at its lower end, and designed so that a vacuum is created during use, said vacuum serving to retain undeformed a plug of tissue cut from a patient's skin.

  16. “Malignant Cutaneous Ulcer”

    OpenAIRE

    Sundriyal, Deepak; Kotwal, Sumedha

    2015-01-01

    Renal cell carcinoma (RCC) is an aggressive malignancy and the rich vascular supply enables it to metastasize early via haematogenous route. Skin lesions are a late manifestation of the disease. Clinicians should be aware of cutaneous presentation of RCC while evaluating a case of unknown primary with skin lesions.

  17. Hyaline fibromatosis syndrome: cutaneous manifestations*

    Science.gov (United States)

    Marques, Silvio Alencar; Stolf, Hamilton Ometto; Polizel, Juliana Ocanha; Munhoz, Tânia; Brandão, Marcela Calixto; Marques, Mariangela Esther Alencar

    2016-01-01

    Hyaline fibromatosis syndrome is the current name for clinical manifestations of diseases previously known as “infantile systemic hyalinosis” and “juvenile hyaline fibromatosis”. The authors report representative clinical cases of each one of the above subtypes with emphasis on cutaneous manifestations and difficulties for early diagnosis in this syndrome, essentially of multidisciplinary approach. PMID:27192526

  18. Cutaneous Metastases From Esophageal Adenocarcinoma

    Science.gov (United States)

    Triantafyllou, Stamatina; Georgia, Doulami; Gavriella-Zoi, Vrakopoulou; Dimitrios, Mpistarakis; Stulianos, Katsaragakis; Theodoros, Liakakos; Georgios, Zografos; Dimitrios, Theodorou

    2015-01-01

    The aim of this study is to present 2 rare cases of cutaneous metastases originated from adenocarcinoma of the gastro-esophageal junction, thus, underline the need for early diagnosis and possible treatment of suspicious skin lesions among patients with esophageal malignancy. Metastatic cancer to the skin originated from internal malignancies, mostly lung cancer, breast cancer, and colorectal cancer, constitute 0.5 to 9% of all metastatic cancers.5,8,15 Skin metastases, mainly from squamous cell carcinomas of the esophagus, are rarely reported. Cutaneous metastasis is a finding indicating progressiveness of the disease.17 More precisely, median survival is estimated approximately 4.7 months.2,14 This study is a retrospective review of 2 cases of patients with adenocarcinoma of the esophagus and a review of the literature. Two patients aged 60 and 32 years old, respectively, underwent esophagectomy. Both pathologic reports disclosed adenocarcinoma of the gastro-esophageal junction staged T3 N2 M0 (stage IIIB). During follow-up time, the 2 patients were diagnosed with cutaneous metastases originated from the primary esophageal tumor 11 and 4 months after surgery, respectively. The first patient is alive 37 months after diagnosis, while the second one died 16 months after surgery. Cutaneous metastasis caused by esophageal adenocarcinoma is possible. Therefore, follow-up of patients who were diagnosed with esophageal malignancy and underwent esophagectomy is mandatory in order to reveal early surgical stages. PMID:25785344

  19. Parasitic Diseases With Cutaneous Manifestations.

    Science.gov (United States)

    Ash, Mark M; Phillips, Charles M

    2016-01-01

    Parasitic diseases result in a significant global health burden. While often thought to be isolated to returning travelers, parasitic diseases can also be acquired locally in the United States. Therefore, clinicians must be aware of the cutaneous manifestations of parasitic diseases to allow for prompt recognition, effective management, and subsequent mitigation of complications. This commentary also reviews pharmacologic treatment options for several common diseases.

  20. [Cutaneous manifestations of leukemia].

    Science.gov (United States)

    Pulido-Díaz, Nancy; Medina, Gabriela; Palomino, Nymrod; Peralta, Fidelio

    2015-01-01

    Introducción: el objetivo de este estudio es describir la frecuencia y tipo de manifestaciones cutáneas en pacientes con leucemia.Métodos: estudio observacional, descriptivo. Se incluyeron pacientes mayores de 16 años, con diagnóstico confirmado de leucemia, de los departamentos de Hematología y Dermatología procedentes de la consulta externa u hospitalizados. Se excluyeron los pacientes trasplantados de médula ósea. Se les efectuó historia clínica y revisión dermatológica completa de la piel y anexos, toma de biopsias y cultivos en caso de requerirlo. Las manifestaciones cutáneas se clasificaron en manifestaciones secundarias a procesos infecciosos o medicamentos, infiltración leucémica, dermatosis asociadas a la leucemia y lesiones inespecíficas. Se empleó estadística descriptiva.Resultados: Se incluyeron 142 pacientes con los siguientes diagnósticos: leucemia mieloide aguda (n = 36 pacientes), leucemia linfoblástica aguda (n = 52), leucemia mieloide crónica (n = 21), leucemia linfocítica crónica (n = 30), leucemia de células peludas (n = 3). El 42.25 % de los pacientes (n = 60) presentaron hallazgos positivos para alguna dermatosis. Se encontraron 36 dermatosis inespecíficas, 21 medicamentosas, 20 infecciosas, 3 infiltrativas y ninguna asociada.Conclusiones: las manifestaciones cutáneas directamente relacionadas a leucemia son frecuentes, siendo las inespecíficas las más comúnmente observadas. Sin embargo, el examen dermatológico completo es importante en estos pacientes como parte de su evaluación integral.

  1. Video a les aules

    OpenAIRE

    Ramírez León, Vanessa

    2012-01-01

    Memòria del Projecte Final de Màster "Vídeo a les aules", consistent en una plataforma col·laborativa online per potenciar l'ús didàctic del vídeo a l'aula. "Video in the classroom" is an online collaborative platform to promote the educational use of video in the classroom. Memoria del Proyecto Final de Máster "Video en las aulas", consistente en una plataforma colaborativa online para potenciar el uso didáctico del vídeo en el aula.

  2. Avaliação da atividade cicatrizante do jucá (Caesalpinia ferrea Mart. ex Tul. var. ferrea em lesões cutâneas de caprinos Evaluation of the Brazilian ironwood (Caesalpinia ferrea Mart. ex Tul. var. ferrea healing activity on cutaneous lesions of goats

    Directory of Open Access Journals (Sweden)

    A.F. Oliveira

    2010-09-01

    Full Text Available O objetivo deste estudo foi demonstrar os efeitos do tratamento tópico do jucá (Caesalpinia ferrea em feridas cutâneas. Quinze caprinos machos sem raça definida foram divididos em 3 grupos de acordo com o pós-cirúrgico (7º, 14º e 21º dias. As feridas experimentais foram tratadas com a pomada composta pela casca da Caesalpinia ferrea em pó misturada com a vaselina estéril e as do grupo controle apenas com a vaselina esterilizada. A aplicação diária da pomada e da vaselina estéril foi realizada sobre ferida circular padronizada de 16 cm² de área na região torácica de cada animal. As avaliações das feridas foram feitas do ponto de vista clínico, bacteriológico, morfométrico e histopatológico nos períodos pré-determinados (7º, 14º e 21º dias. Morfometricamente, as feridas do controle apresentaram áreas cirúrgicas menores e grau de contração maior que as do grupo tratado, entretanto, histologicamente, houve completa epitelização das feridas tratadas no 21º dia, enquanto que as feridas do grupo controle necessitavam de mais tempo para resolução do processo cicatricial. No exame microbiológico realizado no momento da produção da ferida, não se observou crescimento bacteriano e no momento das biópsias, identificou-se a presença de bactérias da família Enterobacteriaceae e Staphylococcus aureus, sendo que a partir do 14º dia observou-se Staphylococcus aureus apenas no grupo controle. A utilização tópica da pomada de Caesalpinia ferrea apresentou eficiência significativa no auxílio da reparação cicatricial de feridas cutâneas de caprinos.The aim of this study was to demonstrate the effects of the topical treatment with Brazilian ironwood (Caesalpinia ferrea on cutaneous wounds. Fifteen male mongrel goats were divided into 3 groups according to the postoperative period ((7th, 14th and 21st days. The experimental wounds were treated with an ointment composed of Brazilian wood powder bark mixed with

  3. Les perspectives nutritionnelles offertes par les OGM en alimentation humaine

    Directory of Open Access Journals (Sweden)

    Pascal Gérard

    2004-03-01

    Full Text Available Une étude des brevets récents, des publications scientifiques ainsi que des documents présentant les projets des firmes de biotechnologie constituent la base de cet article qui présente les perspectives de développement en alimentation humaine des organismes génétiquement modifiés (OGM présentant un intérêt nutritionnel. Si l’on trouve dans les brevets et les publications scientifiques des applications qui concernent l’amélioration ou l’enrichissement de la composition en macro- et micronutriments, ces applications restent curieusement à l’état de projets, très loin de la mise sur le marché. Les critiques aussi bien que les louanges dont sont l’objet les rares cas dont on pourrait envisager une mise en œuvre à moyen terme, comme le « riz doré », sont aussi injustifiées et excessives les unes que les autres. Les violentes polémiques autour des OGM risquent de handicaper le développement d’une technique puissante, qui n’est certes pas indispensable pour apporter une solution à l’éradication de la faim dans le monde, mais qui peut apporter des améliorations à la nutrition des populations, aussi bien des populations des pays en développement que des pays développés.

  4. GABLS3-LES Intercomparison Study

    NARCIS (Netherlands)

    Basu, S.; Holtslag, A.A.M.; Bosveld, F.C.

    2012-01-01

    Recently, a large-eddy simulation (LES) intercomparison study was organized under the auspices of the GEWEX Atmospheric Boundary Layer Study (GABLS). Eleven LES modelling groups around the world participated in this study to model a baroclinic, mid-latitude nighttime stable boundary layer utilizing

  5. Cutaneous manifestations of human toxocariasis.

    Science.gov (United States)

    Gavignet, Béatrice; Piarroux, Renaud; Aubin, François; Millon, Laurence; Humbert, Philippe

    2008-12-01

    Human toxocariasis is a parasitic disease characterized by the presence of larvae of the genus Toxocara in human tissues. T canis and T cati, the adult roundworms of which are found in dog and cat intestines, respectively, are the most common causative agents of the disease. Toxocaral larvae usually cause two severe syndromes: visceral larva migrans and ocular larva migrans, depending on the location of the larvae. Two other syndromes, covert toxocariasis and common toxocariasis, which are less typical and not as severe, have also been described. During the last two decades, cutaneous manifestations such as chronic urticaria, chronic pruritus, and miscellaneous eczema, in patients with Toxocara antibodies, have been studied by different authors. In some cases, these cutaneous manifestations are the only signs indicating the presence of the disease, and they are cured after antihelmintic treatment when there is good patient compliance. In this review, we focus on these particular skin manifestations regarding their clinical description, diagnosis, and treatment.

  6. Cutaneous myiasis from Dermatobia hominis.

    Science.gov (United States)

    Guse, S T; Tieszen, M E

    1997-08-01

    We present a case report of cutaneous myiasis in a foreign traveler who was infected by Dermatobia hominis while visiting South America. This patient developed a painful furuncular lesion on the anterior scalp and noted that the lesion drained a serosanguinous fluid for more than a month before definitive treatment. Invasion of mammalian tissue by the larval forms of D. hominis typically results in the formation of a classic furuncular lesion. For persons who present with a lesion that contains a central draining stoma located on an exposed body surface, the diagnosis of myiasis should always be considered. In addition to the case report, we present a discussion of furuncular myiasis and describe the peculiar life cycle of the human botfly. We also describe the various therapies that may be employed for treating cutaneous myiasis, including surgical extraction of the larva and asphyxiation of the larva by application of petroleum jelly or other fat derivatives to the central stoma or breathing aperture.

  7. Multiple isolated cutaneous plexiform schwannomas

    Directory of Open Access Journals (Sweden)

    Enas A. S. Attia

    2011-01-01

    Full Text Available Plexiform schwannoma is a rare neurogenic tumor, arising from skin and subcutaneous tissue. The presence of multiple schwannomas suggests a possible association with neurofibromatosis type 2 (NF2. A 50-year old male patient presented with multiple papulo-nodular cutaneous lesions on both arms and forearms. Histopathological examination revealed a dermal multinodular pattern of well-circumscribed masses of closely packed cells, with peripheral myxoid tissue, well-encapsulated in a thin collagenous capsule. S-100 immunohistochemical staining was diffusely and strongly positive. Neuron-specific enolase was positive, confirming a neural tissue tumor. An audiogram and Magnetic Resonance Imaging (MRI of cerebro-pontine angle showed no detected abnormality, excluding acoustic neuroma. Thus, we present a case of multiple bilateral isolated cutaneous plexiform schwannomas, not associated with NF2. Multiple plexiform schwannomas is a very rare entity, distinct from neurofibromatosis (NF, and being confined to the dermis is even more rarely reported.

  8. Carcinoma in cutaneous Lichen Planus

    Directory of Open Access Journals (Sweden)

    Rahul Shetty

    2013-01-01

    Full Text Available Carcinoma occurring in the cutaneous lesions of Lichen Planus though rarely mentioned in literature does occur and should be kept in mind while treating such lesions. We report a 16 year female who developed a squamous cell carcinoma in a long standing verrucous lichen planus in the lower leg. This case is being presented to indicate the possibility of malignant transformation of cutaneous lichen planus to carcinoma, especially in the hypertrophic forms and the need to have an early diagnosis so that it can be treated in the initial stages. A high degree of suspicion should be present whenever we come across a non healing lesion in a patient with lichen planus. A few markers, which may give us a clue for increased chances of malignant transformation in these cases is presented.

  9. Cutaneous manifestations of viral hepatitis.

    Science.gov (United States)

    Akhter, Ahmed; Said, Adnan

    2015-02-01

    There are several extrahepatic cutaneous manifestations associated with hepatitis B and hepatitis C virus infection. Serum sickness and polyarteritis nodosa are predominantly associated with hepatitis B infection, whereas mixed cryoglobulinemia associated vasculitis and porphyria cutanea tarda are more frequently seen in hepatitis C infection. The clinico-pathogenic associations of these skin conditions are not completely defined but appear to involve activation of the host immune system including the complement system. Management of the aforementioned cutaneous manifestations of viral hepatitis is often similar to that done in cases without viral hepatitis, with control of immune activation being a key strategy. In cases associated with hepatitis B and C, control of viral replication with specific antiviral therapy is also important and associated with improvement in most of the associated clinical manifestations.

  10. Mieloma múltiplo com plasmocitomas cutâneos Multiple myeloma with cutaneous plasmocytomas

    Directory of Open Access Journals (Sweden)

    Daniella Abbruzzini Ferreira de Souza

    2004-10-01

    Full Text Available O mieloma múltiplo é neoplasia de células plasmáticas que infiltram a medula óssea; as lesões cutâneas no mieloma múltiplo são raras, inespecíficas ou específicas, sendo estas últimas primárias ou secundárias. Lesões específicas secundárias de pele em pacientes com mieloma ocorrem por extensão direta para a pele, a partir de lesões ósseas subjacentes, ou como plasmocitomas extramedulares metastáticos. Os autores relatam caso de paciente de 59 anos, que apresentou diagnóstico de mieloma múltiplo e, após sete meses de evolução, desenvolveu plasmocitomas cutâneos, caracterizados por nódulos eritêmato-violáceos nas extremidades.Multiple myeloma is a malignant proliferation of plasma cells which infiltrate bone marrow; cutaneous involvement with plasma cell neoplasms is uncommon, and may be nonspecific or specific. The specific dermatologic lesions arise either as a direct extension from the underlying bone lesions or by metastatic accumulation in the form of nodules and plaques. The authors report the case of a 59-year-old male patient with multiple myeloma, who developed cutaneous plasmacytomas (violaceous nodules on the limbs seven months after the disease diagnosis.

  11. Cutaneous metastasis in anorectal adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Krishnendra Varma

    2015-01-01

    Full Text Available Cutaneous metastasis in anorectal adenocarcinoma is a rare entity. Here, we report the case of a 40-year-old female who presented with yellowish-brown, irregular, solid, elevated rashes over the pubis with a recent history off palliative colostomy for anorectal adenocarcinoma. Clinically, we suspected metastasis that was proved on biopsy. We report this case due to the rare presenting site (i.e., perineum of a metastatic adenocarcinoma.

  12. Cutaneous and mucosal pain syndromes

    Directory of Open Access Journals (Sweden)

    Siddappa K

    2002-01-01

    Full Text Available The cutaneous and mucosal pain syndromes are characterized by pain, burning sensation, numbness or paraesthesia of a particular part of the skin or mucosal surface without any visible signs. They are usually sensory disorders, sometimes with a great deal of psychologic overlay. In this article various conditions have been listed and are described. The possible causative mechanisms are discussed when they are applicable and the outline of their management is described.

  13. Pathophysiology of cutaneous lupus erythematosus

    OpenAIRE

    Achtman, Jordan C; Werth, Victoria P.

    2015-01-01

    The pathophysiology of cutaneous lupus erythematosus (CLE) encompasses the complex interactions between genetics, the environment, and cells and their products. Recent data have provided enhanced understanding of these interactions and the mechanism by which they cause disease. A number of candidate genes have been identified which increase the risk of developing CLE. Ultraviolet radiation, the predominant environmental exposure associated with CLE, appears to initiate CLE lesion formation by...

  14. Cutaneous polyarteritis nodosa: an update.

    Science.gov (United States)

    Furukawa, Fukumi

    2012-01-01

    Cutaneous symptoms are observed in 25%-60% of polyarteritis nodosa (PN) patients. On the other hand, cutaneous polyarteritis nodosa (CPN) is designated for the cutaneous limited form of PN and demonstrates benign prognosis. However, there has been much debate on whether or not CPN can progress to PN. Although CPN lesions are fundamentally limited to skin, some CPN cases show extracutaneous symptoms such as peripheral neuropathy and myalgia. According to PN diagnostic criteria, a disease with both cutaneous and at least one extracutaneous symptom with appropriate histopathological findings can be diagnosed as PN. The same is true according to diagnostic criteria established by American College of Rheumatology (ACR). In addition, there are no specific diagnostic criteria for CPN. In this study, CPN cases were retrospectively collected from multiple Japanese clinics, and analyzed for detailed clinical and histopathological manifestations, in order to redefine the clinical entity of CPN and to propose appropriate diagnostic criteria for CPN and PN. According to the CPN description in Rook's Textbook of Dermatology, one of global standard textbooks, we collected 22 cases with appropriate histopathological findings. Of the 22 cases, none progressed to PN or death during the follow-up period, 32% had peripheral neuropathy, and 27% had myalgia. Regarding extracutaneous symptoms with CPN, 17 dermatological specialists in vasculitis sustained the opinion that CPN can be accompanied by peripheral neuropathy and myalgia, but these symptoms are limited to the same area as skin lesions. Based on these results, we devised new drafts for CPN and PN diagnostic criteria. Our study shows the efficacy of these criteria, and most dermatologists recognized that our new diagnostic criteria for CPN and PN are appropriate at the present time. In conclusion, this study suggests that CPN does not progress to PN, and introduces new drafts for CPN and PN diagnostic criteria. (*English

  15. Newly recognized cutaneous drug eruptions.

    Science.gov (United States)

    Callen, Jeffrey P

    2007-04-01

    Many new drugs are entering the marketplace and although some cutaneous reactions might be noted in the preclinical evaluation, some of the reactions, particularly those that are rare, will not be noted until the drugs enter widespread use. In addition, distinctive reactions may occur, as is the case with epidermal growth factor-receptor inhibitors. Careful observation and evaluation might result in a better understanding of "naturally" occurring skin disease.

  16. Unusual presentation of cutaneous leiomyoma

    Directory of Open Access Journals (Sweden)

    Sapnashree Bhaskar

    2014-01-01

    Full Text Available Herein, we report a case of leiomyoma cutis because of its rarity and unusual presentation. The case presented with a solitary leiomyoma lesion which was painless. However, the adjacent normal appearing area was tender. A biopsy of the lesion as well as of a portion of the adjacent normal appearing area was taken, which confirmed the diagnosis of cutaneous leiomyoma. This may suggest the dormant nature of the disease which has not yet become apparent.

  17. Unusual Presentation of Cutaneous Leiomyoma

    Science.gov (United States)

    Bhaskar, Sapnashree; Jaiswal, Ashok K; Madhu, SM; Santosh, KV

    2014-01-01

    Herein, we report a case of leiomyoma cutis because of its rarity and unusual presentation. The case presented with a solitary leiomyoma lesion which was painless. However, the adjacent normal appearing area was tender. A biopsy of the lesion as well as of a portion of the adjacent normal appearing area was taken, which confirmed the diagnosis of cutaneous leiomyoma. This may suggest the dormant nature of the disease which has not yet become apparent. PMID:25484434

  18. Immunogenetics of cutaneous lupus erythematosus.

    Science.gov (United States)

    Hersh, Aimee O; Arkin, Lisa M; Prahalad, Sampath

    2016-08-01

    Systemic lupus erythematosus (SLE) is the prototypic autoimmune condition, often affecting multiple organ systems, including the skin. Cutaneous lupus erythematosus (CLE) is distinct from SLE and may be skin limited or associated with systemic disease. Histopathologically, the hallmark of lupus-specific manifestations of SLE and CLE is an interface dermatitis. The cause of SLE and CLE is likely multifactorial and may include shared genetic factors. In this review, we will discuss the genetic findings related to the cutaneous manifestations of SLE and isolated CLE, with a particular focus on the lupus-specific CLE subtypes. Several major histocompatibility complex and nonmajor histocompatibility complex genetic polymorphisms have been identified which may contribute to the cutaneous manifestations of SLE and to CLE. Most of these genetic variants are associated with mechanisms attributed to the pathogenesis of SLE, including pathways involved in interferon and vitamin D regulation and ultraviolet light exposure. Although there is overlap between the genetic factors associated with SLE and CLE, there appear to be unique genetic factors specific for CLE. Improved understanding of the genetics of CLE may lead to the creation of targeted therapies, improving outcomes for patients with this challenging dermatologic condition.

  19. Cutaneous Chromatophoromas in Captive Snakes.

    Science.gov (United States)

    Muñoz-Gutiérrez, J F; Garner, M M; Kiupel, M

    2016-11-01

    Chromatophoromas are neoplasms arising from pigment-bearing cells (chromatophores) of the dermis. While isolated cases have been reported in the literature, the prevalence and biological behavior of chromatophoromas in snakes are unknown. Forty-two chromatophoromas were identified among 4663 submissions (0.9%) to a private diagnostic laboratory in a 16-year period. The most commonly affected snakes were colubrids (23 cases, 55%) and vipers (8 cases, 19%). The San Francisco garter snake was the most commonly affected species (6 cases; 14% of all affected snake species and 3.7% of all garter snake submissions). No sex predilection was found. The age of 28 snakes ranged from 5 to 27 years. Single cutaneous chromatophoromas were most commonly observed and presented as pigmented cutaneous masses or plaques along any body segment. Euthanasia or death due to progressive neoplastic disease or metastasis was reported in 8 (19%) and 4 (10%) cases, respectively. The survival time of 4 animals ranged from 4 to 36 months. Microscopically, xanthophoromas, iridophoromas, melanocytic neoplasms, and mixed chromatophoromas were identified, with melanocytic neoplasms being most common. Microscopic examination alone was generally sufficient for the diagnosis of chromatophoroma, but immunohistochemistry for S-100 and PNL-2 may be helpful for diagnosing poorly pigmented cases. Moderate to marked nuclear atypia appears to be consistently present in cutaneous chromatophoromas with a high risk of metastasis, while mitotic count, lymphatic invasion, the level of infiltration, and the degree of pigmentation or ulceration were not reliable predictors of metastasis.

  20. Cutaneous manifestations of internal malignancy

    Directory of Open Access Journals (Sweden)

    A Ayyamperumal

    2012-01-01

    Full Text Available Background: Many malignancies affecting the internal organs display cutaneous manifestations which may be either specific (tumor metastases or nonspecific lesions. Aims: The study is aimed at determining the frequency and significance of cutaneous manifestations among patients with internal malignancy. Materials and Methods: 750 cases of proven internal malignancy, who attended a cancer chemotherapy center in South India, were studied. Specific infiltrates were confirmed by histopathology, fine needle aspiration cytology (FNAC and marker studies. Results: Out of the 750 patients with internal malignancy, skin changes were seen in a total of 52 (6.93% patients. Conclusion: Cutaneous metastases (specific lesions were seen in 20 patients (2.66%: contiguous in 6 (0.8%, and non-contiguous in 14 (1.86%. Nonspecific skin changes were seen in 32 patients (4.26%. None of our patients presented with more than one type of skin lesions. Herpes zoster was the most common nonspecific lesion noticed in our patients, followed by generalized pruritus, multiple eruptive seborrheic keratoses, bullous disorder, erythroderma, flushing, purpura, pyoderma gangrenosum, insect bite allergy and lichenoid dermatitis.

  1. Ampullary carcinoma with cutaneous metastasis

    Directory of Open Access Journals (Sweden)

    I-Ting Liu

    2016-06-01

    Full Text Available Carcinoma of the ampulla of Vater is a rare gastrointestinal tumor. Additionally, cutaneous metastasis from such an internal malignancy is also uncommon. We reported the case of a 55-year-old man afflicted with ampullary carcinoma with cutaneous metastasis. The patient did not undergo the standard Whipple procedure but received chemotherapy due to apparent left neck lymph node metastasis noted by initial PET/CT imaging. The skin metastasis presented as a left neck infiltrating purpuric lesion, which was confirmed by skin biopsy approximately one year after the patient's disease was first diagnosed. Thereafter, the patient received further chemotherapy pursuant to his course of medical management. Skin metastasis usually represents a poor patient prognosis. In these cases, treatment of cutaneous metastasis typically includes systemic chemotherapy and local management such as radiation therapy or tumor excision. And when choosing a chemotherapy regimen for the ampullary cancer, the histological subtypes (intestinal or pancreatobiliary should be comprehensively considered. In our review of the literature, the intestinal type seems to have less distant lymph node metastasis, advanced local invasion, as well as recurrence than pancreatobiliary type of ampullary cancer.

  2. Les infections nosocomiale

    OpenAIRE

    AMMOLR, Naima; ZEKRI, DjaIeI; Lazreg, Mohammed

    2006-01-01

    L'infection hospitalière est un phénomène grave et coûteux pour la société et pour le malade; • elle prolonge la durée de séjours; • augmente la consommation thérapeutique ( antibiotique, antalgique...); • entraîne une mobilisation excessive du personnel; • nuit la réputation du personnel soignant et de l'établissement; • multiplie l'évaluation du coût de prise en charge; • induit des séquelles neurologiques irréversibles. Mieux vaut investir dans les mesures de préven...

  3. Les infections nosocomiale

    OpenAIRE

    AMMOLR, Naima; ZEKRI, DjaIeI; Lazreg, Mohammed

    2006-01-01

    L'infection hospitalière est un phénomène grave et coûteux pour la société et pour le malade; • elle prolonge la durée de séjours; • augmente la consommation thérapeutique ( antibiotique, antalgique...); • entraîne une mobilisation excessive du personnel; • nuit la réputation du personnel soignant et de l'établissement; • multiplie l'évaluation du coût de prise en charge; • induit des séquelles neurologiques irréversibles. Mieux vaut investir dans les mesures de préven...

  4. Les lueurs des sables

    CERN Multimedia

    Les lueurs des sables

    2013-01-01

    Two CERN ladies are getting ready for the “Trophée Roses des Sables” rally adventure: Julie and Laetitia are finalizing the last details before setting off on Monday 7th October 2013. Julie from EN-MEF group and Laetitia from DGS-SEE group, met at the CERN Rugby club. This year, they are participating in the 100 % female rally which will take place in Morocco from 10 to 20 October. They will be carrying along 100 kg of humanitarian donation for children such as some clothes, books and medical material. Do not hesitate to show your support at their farewell party to be held on Monday 7 October, from 4 to 6 pm in front of the St Genis-Pouilly Mairie (city Hall). Follow their exciting adventure on the blog leslueursdessables.trophee-roses-des-sables.org and on their association’s Facebook page Les Lueurs des Sables.

  5. [Cutaneous adverse effects of TNFalpha antagonists].

    Science.gov (United States)

    Failla, V; Sabatiello, M; Lebas, E; de Schaetzen, V; Dezfoulian, B; Nikkels, A F

    2012-01-01

    The TNFalpha antagonists, including adalimumab, etanercept and infliximab, represent a class of anti-inflammatory and immunosuppressive drugs. Although cutaneous adverse effects are uncommon, they are varied. There is no particular risk profile to develop cutaneous adverse effects. The principal acute side effects are injection site reactions and pruritus. The major long term cutaneous side effects are infectious and inflammatory conditions. Neoplastic skin diseases are exceptional. The association with other immunosuppressive agents can increase the risk of developing cutaneous adverse effects. Some adverse effects, such as lupus erythematosus, require immediate withdrawal of the biological treatment, while in other cases temporary withdrawal is sufficient. The majority of the other cutaneous adverse effects can be dealt without interrupting biologic treatment. Preclinical and clinical investigations revealed that the new biologics, aiming IL12/23, IL23 and IL17, present a similar profile of cutaneous adverse effects, although inflammatory skin reactions may be less often encountered compared to TNFalpha antagonists.

  6. Les plans de gestion de crises dans les pays francophones

    OpenAIRE

    Barkaoui, Houssem; Guinet, Alain; Tao, Wang; Meskens, Nadine

    2016-01-01

    International audience; La gestion des catastrophes, appelée plus communément gestion des situations d'urgences ou encore gestion de crises, est la discipline qui s'intéresse à l'évaluation des menaces et de leurs risques relatifs ainsi qu'aux stratégies mises en oeuvre afin d'en limiter l'occurrence ou les conséquences en cas de survenue. Dans ce papier, nous allons étudier le cadre réglementaire et les mesures prises par les gouvernements pour gérer des situations exceptionnelles de crises ...

  7. Cutaneous manifestations of inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Al Roujayee Abdulaziz

    2007-01-01

    Full Text Available Inflammatory bowel disease (IBD has many extraintestinal manifestations, and skin lesions are one of the most frequently described extraintestinal findings. Reports indicate an incidence of cutaneous manifestations ranging from 2 to 34%, Cutaneous manifestations are usually related to the activity of the bowel disease but may have an independent course. In this review we aim to address the various cutaneous manifestations associated with IBD, their impact on the disease course, and the treatment options available.

  8. Les retractions cervicales post-brulure - a propos de 49 cas et revue de la litterature

    Science.gov (United States)

    Elamrani, D.; Zahid, A.; Aboujaafr, N.; Diouri, M.; Bahechar, N.; Boukind, E.H.

    2011-01-01

    Summary Les brides cervicales post-brûlure sont la conséquence de brûlures profondes, souvent négligées ou mal prises en charge. Elles affectent la fonction, l’esthétique et l’état psychologique des patients et peuvent être de traitement difficile. A partir d’une étude rétrospective étalée sur une période de six ans (janvier 2002-janvier 2008), nous avons analysé les caractéristiques épidémiologiques et cliniques ainsi que les indications et les résultats thérapeutiques chez 49 patients présentant des brides cervicales post-brûlure, suivis au Centre National des Brûlés et de Chirurgie Plastique de Casablanca. L’enfant et l’adulte jeune sont les plus touchés, avec une légère prédominance féminine (59,2%). Les brûlures domestiques sont les plus fréquentes (93,9%) et l’étiologie de l’accident est dominée par la brûlure thermique (98,0%). Les brides cervicales modérées et sévères (selon la classification d’Achauer) sont les plus fréquentes et représentent respectivement 30,6% et 38,8% des cas. Le traitement chirurgical a fait appel aux greffes cutanées dans 67,3% des cas, aux plasties locales dans 24,5% des cas et aux lambeaux dans 8,2% des cas. Chez les 47 patients suivis à long terme, les résultats fonctionnels et esthétiques sont jugés bons dans 83,0% des cas et moyens dans 8,5% des cas, tandis que les cas restants (8,5%) ont nécessité une reprise chirurgicale. Sur le plan épidémiologique (âge, sexe, caractéristiques de la brûlure) et clinique (localisation des séquelles, formes cliniques), les résultats de notre série sont comparables aux données de la littérature. Le rôle de la prise en charge initiale (excision-greffe précoce, pressothérapie et immobilisation par minerve) dans la réduction de l’incidence et de la sévérité des séquelles de brûlures cervicales est prouvé. Lorsqu’un traitement chirurgical est indiqué, le choix du procédé de réparation dépend essentiellement de

  9. Cutaneous dermatomyositis in the era of biologicals.

    Science.gov (United States)

    Wright, Natalie A; Vleugels, Ruth Ann; Callen, Jeffrey P

    2016-01-01

    Dermatomyositis (DM) is a systemic inflammatory condition characterized by cutaneous and muscle findings, in addition to potential involvement of other organ systems. A distinct subtype of DM exists that is categorized by cutaneous findings with absent or minimal muscle involvement, referred to as clinically amyopathic dermatomyositis or dermatomyositis sine myositis. A variety of topical, immunosuppressive, and immunomodulatory therapies have been utilized to treat cutaneous DM. The advent of biological agents including tumor necrosis factor-α antagonists, intravenous immunoglobulin, rituximab, and others has allowed for the use of these agents with varying degrees of success for the treatment of cutaneous DM.

  10. Serum adenosine deaminase activity in cutaneous anthrax.

    Science.gov (United States)

    Sunnetcioglu, Mahmut; Karadas, Sevdegul; Aslan, Mehmet; Ceylan, Mehmet Resat; Demir, Halit; Oncu, Mehmet Resit; Karahocagil, Mustafa Kasım; Sunnetcioglu, Aysel; Aypak, Cenk

    2014-07-06

    Adenosine deaminase (ADA) activity has been discovered in several inflammatory conditions; however, there are no data associated with cutaneous anthrax. The aim of this study was to investigate serum ADA activity in patients with cutaneous anthrax. Sixteen patients with cutaneous anthrax and 17 healthy controls were enrolled. We measured ADA activity; peripheral blood leukocyte, lymphocyte, neutrophil, and monocyte counts; erythrocyte sedimentation rate; and C reactive protein levels. Serum ADA activity was significantly higher in patients with cutaneous anthrax than in the controls (panthrax.

  11. Cutaneous histoplasmosis in renal transplant recipients.

    Science.gov (United States)

    Sun, N Z; Augustine, J J; Gerstenblith, M R

    2014-10-01

    Cutaneous histoplasmosis is a rare entity, although it can be seen in a substantial portion of renal transplant recipients with disseminated disease. The prognosis of disseminated disease is worse than isolated cutaneous involvement, and significant delays in diagnosis are reported. We reviewed reports of cutaneous histoplasmosis with and without dissemination in the setting of renal transplantation to examine incidence, timing of diagnosis, clinical features, and prognosis. Remarkable morphologic variability and the non-specific appearance of skin findings suggest that tissue culture is required for definitive diagnosis. Cutaneous lesions represent an easily accessible source for early diagnosis.

  12. Remote Cutaneous Breast Carcinoma Metastasis Mimicking Dermatitis

    Directory of Open Access Journals (Sweden)

    Annakan V Navaratnam

    2015-01-01

    Full Text Available Cutaneous metastases from primary internal malignancies are an uncommon presentation. Cutaneous metastases are more frequently seen in breast cancer than in any other visceral malignancy in women. Medical practitioners should be vigilant of the possibility of unusual presentations of metastatic disease in breast cancer patients with lobular carcinoma presenting as cutaneous lesions mimicking benign dermatological conditions. Herein, we present a case of a 75-year-old woman presenting with cutaneous lobular breast carcinoma metastases on her anterior right leg, which had previously been misdiagnosed as dermatitis for 9 years.

  13. Les jardins de la physique

    CERN Document Server

    Allemand, Luc

    2017-01-01

    À l'écart du monde, loin des laboratoires, en contact avec la nature, des savants réputés du monde entier viennent enseigner les grands sujets de la physique et partager les dernières avancées avec de nombreux élèves. À l'écart du monde, loin des laboratoires, en contact avec la nature, des savants réputés du monde entier viennent enseigner les grands sujets de la physique et partager les dernières avancées avec de nombreux élèves. Ces hauts-lieux sont propices à la méditation et procurent autant d'opportunités de rencontres et d'échanges. La liberté de pensée qui y règne permet d'explorer de nouvelles pistes pour la physique de demain. Car les grandes découvertes surviennent rarement comme des illuminations : elles résultent plutôt de lentes maturations, accompagnées de travail acharné et de discussions suivies. De tels lieux existent depuis les années 1950 en France : l'Institut d'Études scientifiques de Cargèse, en Corse, et l'École de Physique des Houches, dans les Alpes, ...

  14. Tuberculose multifocale chez les immunocompétents

    Science.gov (United States)

    Rezgui, Amel; Fredj, Fatma Ben; Mzabi, Anis; Karmani, Monia; Laouani, Chadia

    2016-01-01

    La tuberculose multifocale est définie par la l'atteinte d'au moins deux sites extra-pulmonaires associée ou non à une atteinte pulmonaire. On se propose d’étudier les différentes caractéristiques cliniques et évolutives de la tuberculose multifocale à travers une étude rétrospective de 10 cas. Parmi 41 cas de tuberculose colligés entre 1999 et 2013. Dix patients avaient une tuberculose multifocale, soit 24% des patients. Il s'agissait de 9 femmes et 1 homme d’âge moyen à 50 ans (30-68 ans). Nos patients étaient tous correctement vaccinés par le BCG. Un bilan à la recherche d'une éventuelle immunodépression fait pour tous les patients était négatif. Il s'agissait d'une tuberculose ganglionnaire dans 7 cas, digestive dans 3 cas, péricardique dans 2 cas, ostéo-articulaire dans 2 cas, cérébrale dans 1 cas, urinaire dans 2 cas, uro-génitale dans 4 cas, surrénalienne dans 1 cas, cutanée dans 1 cas et musculaire dans 1 cas. Tous nos patients ont bénéficié d'un traitement antituberculeux pour une durée moyenne de 10 mois avec bonne évolution. La tuberculose multifocale est une des maladies à diagnostic difficile. Elle peut toucher les immunocompétents mais son pronostic est souvent bon. Un traitement anti-tuberculeux doit être instauré le plus rapidement possible pour éviter les séquelles. PMID:27583077

  15. Les incentives dans les enquêtes en ligne

    OpenAIRE

    Solène Guillemot

    2013-01-01

    Ce mémoire présente les recherches antérieures d'auteurs s'intéressant aux incentives dans les études marketing et une expérimentation cherchant à vérifier les impacts, à la fois positifs et négatifs, des incentives dans les enquêtes quantitatives en ligne. Ainsi, un questionnaire a été administré par emailing à deux groupes, l'un recevant la possibilité de participer à un tirage au sort (incentive de l'étude), et l'autre n'ayant pas cette possibilité. Il s'agissait dans un premier temps de v...

  16. Les chercheurs inquiets malgre les promesses de Claudie Haignere

    CERN Multimedia

    2003-01-01

    "Le 9 avril, lors d'un colloque sur l'innovation, la ministre deleguee a la recherche et aux nouvelles technologies a annonce, "en plein accord, dit-elle, avec le premier ministre", que "les etablissements publics a caractere scientifique et technologique (EPST) ne connaitront en 2003 aucune nouvelle annulation de credits de paiement et d'autorisations de programme" et que "les reserves de precaution sont entierement levees" (1 page).

  17. Les êtres collectifs en question

    OpenAIRE

    Angeletti, T.; Berlan, A.

    2015-01-01

    Dans quelles situations les individus se retrouvent-ils confrontés à des êtres, des institutions ou des systèmes qui les dépassent ? Comment y font-ils référence ? Quelles solutions théoriques les sciences sociales mobilisent-elles pour en parler ? Ce numéro regroupe des contributions empiriques et théoriques proposant d’étudier et d’expliciter les modes d’existence et d’apparition des êtres collectifs, quand ils sont envisagés comme des vecteurs d’action. Ce faisant, il s’agit de reposer la ...

  18. Les stalles d’Entremont

    OpenAIRE

    Chassany, Chloé

    2010-01-01

    Les stalles sont un rare exemple de siège liturgique. On les trouve dans le chœur des sanctuaires où se réunissaient les communautés pour célébrer collectivement l’office. Les stalles datées du début du XVIe siècle, conservées dans l’église d’Entremont en Haute Savoie, n’ont jamais fait l’objet d’une étude approfondie. La première partie du mémoire réunit le bilan des recherches de première année de master, une synthèse historiographique du mobilier liturgique savoyard ainsi que l’histoire co...

  19. Information sur les technologies nucleaires

    CERN Multimedia

    2002-01-01

    "La base Inis (International Nuclear Information System) de l'Agence Internationale d'Energie Atomique (IAEA) dispose desormais de liens vers les textes complets de documents internationaux" (1 paragraph).

  20. Cutaneous lesions in new born

    Directory of Open Access Journals (Sweden)

    Sachdeva Meenakshi

    2002-11-01

    Full Text Available Five hundred unselected newborn babies delivered in the Department of Obstetrics and Gynaecology, Unit II of SGBT Hospital attached to Government Medical College, Amritsar during April 2000 to October 2000 were examined for cutaneous lesions daily for the first five days after birth. Different cutaneous lesions were seen in 474(94. 8% newborns. The physiological skin changes observed in order of frequency were Epstein pearls in 305(61%, Mongolian spot in 301(60. 2%, superficial cutaneous desquamation in 200(40%, icterus in 128(25. 6%, milia in 119(23. 8%, sebaceous gland hyperplasia in 107 (21. 4%, occipital alopecia in 94(18. 8%, lanugo in 72(14. 4%, peripheral cyanosis in 47(9. 4%, breast hypertrophy in 29(5. 8% and miniature puberty in 28(5. 6% newborns. Of the transient non-infective skin diseases, erythema toxicum neonatorum was observed most commonly in 105(21 %, followed by miliaria rubra in 103(20. 6% and acne neonatorum in 27(5. 4% newborns. The naevi and other developmental defects in the descending order were salmon patch in 69(13. 8%, congenital melanocytic noevi in 10(2%, accessory tragi in 3(0.6%, spina bifida in 2(0.4%, hydrocephalus in 1(0.2% and poliosis in 1(0.2% newborns. Cradle cap was the only dermatitis observed in 50(10% newborns. One (0.2% case each of Harlequin ichthyosis and labial cyst was seen.

  1. Many faces of cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Bari Arfan Ul

    2008-01-01

    Full Text Available Background: Cutaneous leishmaniasis (CL is known for its clinical diversity and increasing numbers of new and rare variants of the disease are being reported these days. Aim: The aim of this descriptive study was to look for and report the atypical presentations of this common disease occurring in Pakistan. Methods: The study was carried out in three hospitals (MH, Rawalpindi; PAF Hospital, Sargodha; and CMH, Muzaffarabad from 2002 to 2006. Military and civilian patients of all ages, both males and females, belonging to central and north Punjab province and Kashmir were included in the study. Clinical as well as parasitological features of cutaneous leishmaniasis were studied. The unusual lesions were photographed and categorized accordingly using simple descriptive statistics. Results: Out of 718 patients of cutaneous leishmaniasis, 41 (5.7% had unusual presentations. The commonest among unusual morphologies was lupoid leishmaniasis 14 (34.1%, followed by sporotrichoid 5 (12.1%, paronychial 3 (7.3%, lid leishmaniasis 2 (4.9%, psoriasiform 2 (4.9%, mycetoma-like 2 (4.9%, erysipeloid 2 (4.9%, chancriform 2 (4.9%, whitlow 1 (2.4%, scar leishmaniasis 1 (2.4%, DLE-like 1 (2.4%, ′squamous cell carcinoma′-like 1 (2.4%, zosteriform 1 (2.4%, eczematous 1 (2.4%, verrucous 1 (2.4%, palmar/plantar 1 (2.4% and mucocutaneous 1 (2.4%. Conclusion: In Pakistan, an endemic country for CL, the possibility of CL should be kept in mind while diagnosing common dermatological diseases like erysipelas, chronic eczema, herpes zoster, paronychia; and uncommon disorders like lupus vulgaris, squamous cell carcinoma, sporotrichosis, mycetoma and other deep mycoses.

  2. Les stocks dans la crise.

    OpenAIRE

    de Rougemont, P.

    2011-01-01

    Fin 2008, un mouvement de déstockage massif et mondial contribue à la forte contraction de l’activité et du commerce international. Ce mouvement est sans doute accentué par les contraintes financières sur les entreprises et par la transmission du choc le long de chaînes de production mondialisées. En sens inverse, mi-2009, le ralentissement du déstockage contribue à une reprise en « V ».

  3. Winter School Les Houches

    CERN Document Server

    Lannoo, Michel; Bastard, Gérald; Voos, Michel; Boccara, Nino

    1986-01-01

    The Winter School held in Les Houches on March 12-21, 1985 was devoted to Semiconductor Heterojunctions and Superlattices, a topic which is recognized as being now one of the most interesting and active fields in semiconductor physics. In fact, following the pioneering work of Esaki and Tsu in 1970, the study of these two-dimensional semiconductor heterostructures has developed rapidly, both from the point of view of basic physics and of applications. For instance, modulation-doped heterojunctions are nowadays currently used to investigate the quantum Hall effect and to make very fast transistors. This book contains the lectures presented at this Winter School, showing in particular that many aspects of semiconductor heterojunctions and super­ lattices were treated, extending from the fabrication of these two-dimensional systems to their basic properties and applications in micro-and opto-electron­ ics. Among the subjects which were covered, one can quote as examples: molecular beam epitaxy and metallorgani...

  4. Targeted therapies for cutaneous melanoma.

    Science.gov (United States)

    Kee, Damien; McArthur, Grant

    2014-06-01

    Melanoma is resistant to cytotoxic therapy, and treatment options for advanced disease have been limited historically. However, improved understanding of melanoma driver mutations, particularly those involving the mitogen-activated protein kinase pathway, has led to the development of targeted therapies that are effective in this previously treatment-refractory disease. In cutaneous melanomas with BRAF V600 mutations the selective RAF inhibitors, vemurafenib and dabrafenib, and the MEK inhibitor, trametinib, have demonstrated survival benefits. Early signals of efficacy have also been demonstrated with MEK inhibitors in melanomas with NRAS mutations, and KIT inhibitors offer promise in melanomas driven through activation of their target receptor.

  5. Cutaneous manifestations of chikungunya fever.

    Science.gov (United States)

    Seetharam, K A; Sridevi, K; Vidyasagar, P

    2012-01-01

    Chikungunya fever, a re-emerging RNA viral infection produces different cutaneous manifestations in children compared to adults. 52 children with chikungunya fever, confirmed by positive IgM antibody test were seen during 2009-2010. Pigmentary lesions were common (27/52) followed by vesiculobullous lesions (16/52) and maculopapular lesions (14/52). Vesiculobullous lesions were most common in infants, although rarely reported in adults. Psoriasis was exacerbated in 4 children resulting in more severe forms. In 2 children, guttate psoriasis was observed for the first time.

  6. Cutaneous Leishmaniasis with Unusual Presentation

    Directory of Open Access Journals (Sweden)

    N Bagherani

    2009-05-01

    Full Text Available "nThis case report states a 25-year-old woman, residing in the city of Dezfool, Khuzestan Province, south of Iran with the diagnosis of cutaneous leishmaniasis in June 2008. Her skin lesion had de­veloped from 8 months earlier as a nodule on her left arm, 1×3 cm in diameter. Because of sever­ity of the lesion, we prescribed meglumine antimoniate intralesionally with giving up her breast feeding. After 6 months follow-up, no recurrence was seen.

  7. Mechanics of cutaneous wound rupture.

    Science.gov (United States)

    Swain, Digendranath; Gupta, Anurag

    2016-11-07

    A cutaneous wound may rupture during healing as a result of stretching in the skin and incompatibility at the wound-skin interface, among other factors. By treating both wound and skin as hyperelastic membranes, and using a biomechanical framework of interfacial growth, we study rupturing as a problem of cavitation in nonlinear elastic materials. We obtain analytical solutions for deformation and residual stress field in the skin-wound configuration while emphasizing the coupling between wound rupture and wrinkling in the skin. The solutions are analyzed in detail for variations in stretching environment, healing condition, and membrane stiffness.

  8. Drug-induced subacute cutaneous lupus erythematosus.

    Science.gov (United States)

    Callen, J P

    2010-08-01

    Subacute cutaneous lupus erythematosus (SCLE) is a subset of cutaneous lupus erythematosus with unique immunologic and clinical features. The first description dates back to 1985 when a series of five patients were found to have hydrochlorothiazide-induced SCLE. Since that time, at least 40 other drugs have been implicated in the induction of SCLE.

  9. "Les Hollande" de Whistler chez Proust

    NARCIS (Netherlands)

    M. van Montfrans

    2011-01-01

    Le rôle que les portraits mondains et les marines de Whistler, l’un des modèles d’Elstir, ont joué dans la Recherche, a fait l’objet de nombreux commentaires. Il n’en est pas de même pour « les Hollande », fruit des séjours fréquents du peintre aux Pays-Bas. Les rares références aux voyages en Holla

  10. Controverses sur les sucres [Controversies about sugars

    Directory of Open Access Journals (Sweden)

    Malika BOUCHENAK

    2016-12-01

    Full Text Available La surconsommation de sucres ajoutés et leurs effets putatifs sur diverses pathologies cardiométaboliques continuent de susciter des controverses. Dans les années 1950, le taux élevé de maladies cardiovasculaires (MCV, chez les hommes Américains a conduit à des études sur le rôle des facteurs alimentaires, tels que le cholestérol, les phytostérols, l'excès de calories, les acides aminés, les graisses, les glucides, les vitamines et les minéraux, à influencer le risque de MCV. Dans les années 60, deux éminents physiologistes, plaidant pour des hypothèses causales divergentes de MCV, John Yudkin a identifié les sucres ajoutés comme agent primaire, tandis que Ancel Keys identifiait les graisses totales, les graisses saturées et le cholestérol alimentaire. Cependant, dans les années 80, peu de scientifiques croyaient que les sucres ajoutés jouaient un rôle important dans la maladie coronarienne, et les premiers conseils nutritionnels de 1980 (1980 Dietary Guidelines for americans étaient axés sur la réduction des graisses totales, des graisses saturées et du cholestérol alimentaire pour la prévention des MCV.

  11. Cutaneous fistulization of the hydatid disease

    Science.gov (United States)

    Bahce, Zeynep Sener; Akbulut, Sami; Aday, Ulas; Demircan, Firat; Senol, Ayhan

    2016-01-01

    Abstract Aim: To provide an overview of the medical literature on cutaneous fistulization in patients with hydatid disease (HD). Methods: According to PRISMA guidelines a literature search was made in PubMed, Medline, Google Scholar, and Google databases were searched using keywords to identify articles related to cutaneous fistulization of the HD. Keywords used were hydatid disease, hydatid cyst, cutaneous fistulization, cysto-cutaneous fistulization, external rupture, and external fistulization. The literature search included case reports, review articles, original articles, and meeting presentations published until July 2016 without restrictions on language, journal, or country. Articles and abstracts containing adequate information, such as age, sex, cyst size, cyst location, clinical presentation, fistula opening location, and management, were included in the study, whereas articles with insufficient clinical and demographic data were excluded. We also present a new case of cysto-cutaneous fistulization of a liver hydatid cyst. Results: The literature review included 38 articles (32 full text, 2 abstracts, and 4 unavailable) on cutaneous fistulization in patients with HD. Among the 38 articles included in the study, 22 were written in English, 13 in French, 1 in German, 1 in Italian, and 1 in Spanish. Forty patients (21 males and 19 females; mean age ± standard deviation, 54.0 ± 21.5 years; range, 7–93 years) were involved in the study. Twenty-four patients had cysto-cutaneous fistulization (Echinococcus granulosus); 10 had cutaneous fistulization (E multilocularis), 3 had cysto-cutaneo-bronchio-biliary fistulization, 2 had cysto-cutaneo-bronchial fistulization; and 1 had cutaneo-bronchial fistulization (E multilocularis). Twenty-nine patients were diagnosed with E granulosis and 11 had E multilocularis detected by clinical, radiological, and/or histopathological examinations. Conclusion: Cutaneous fistulization is a rare complication of HD

  12. Cutaneous sporotrichosis: Unusual clinical presentations

    Directory of Open Access Journals (Sweden)

    Mahajan Vikram

    2010-01-01

    Full Text Available Three unusual clinical forms of sporotrichosis described in this paper will be a primer for the clinicians for an early diagnosis and treatment, especially in its unusual presentations. Case 1, a 52-year-old man, developed sporotrichosis over pre-existing facial nodulo-ulcerative basal cell carcinoma of seven-year duration, due to its contamination perhaps from topical herbal pastes and lymphocutaneous sporotrichosis over right hand/forearm from facial lesion/herbal paste. Case 2, a 25-year-old woman, presented with disseminated systemic-cutaneous, osteoarticular and possibly pleural (effusion sporotrichosis. There was no laboratory evidence of tuberculosis and treatment with anti-tuberculosis drugs (ATT did not benefit. Both these cases were diagnosed by histopathology/culture of S. schenckii from tissue specimens. Case 3, a 20-year-old girl, had multiple intensely pruritic, nodular lesions over/around left knee of two-year duration. She was diagnosed clinically as a case of prurigo nodularis and histologically as cutaneous tuberculosis, albeit, other laboratory investigations and treatment with ATT did not support the diagnosis. All the three patients responded well to saturated solution of potassium iodide (SSKI therapy. A high clinical suspicion is important in early diagnosis and treatment to prevent chronicity and morbidity in these patients. SSKI is fairly safe and effective when itraconazole is not affordable/ available.

  13. Cutaneous signs of classical dermatomyositis.

    Science.gov (United States)

    Auriemma, M; Capo, A; Meogrossi, G; Amerio, P

    2014-10-01

    Idiopathic immune myopathies (IIM) are an heterogeneous group of autoimmune muscle disorders characterized by progressive muscle involvement. Dermatomyositis (DM) is the most common form of IIM. It is a multisystem disorder characterized by symmetric proximal, extensor, inflammatory myopathy, vascular involvement and a characteristic cutaneous eruption. Six types of DM have been identified: idiopathic, juvenile (JDM), cancer-related other autoimmune diseases-related, iatrogenic DM and amyopathic DM. Cutaneous manifestations of DM are the most important aspect of this disease and can precede from several months to years muscle or systemic involvement. Three groups of signs have been described: pathognomonic, highly characteristic and compatible. Although differences exist among the different clinical presentation of skin lesions, they share common histological findings including the presence of interface dermatitis with epidermal atrophy, basement membrane degeneration, vacuolar alteration of basal keratinocytes, and dermal changes consisting of interstitial mucin deposition and a sparse lymphocytic infiltrate. DM is a serious disease; the correct evaluation of any skin lesion suggesting an early diagnosis is of utmost importance. Skin signs may, also, represent a marker of treatment efficacy even though systemic symptoms worsening may not always be followed by more severe skin lesions.

  14. Drug-induced cutaneous vasculitides.

    Science.gov (United States)

    Antiga, E; Verdelli, A; Bonciani, D; Bonciolini, V; Quintarelli, L; Volpi, W; Fabbri, P; Caproni, M

    2015-04-01

    Cutaneous vasculitides (CV) can be idiopathic or secondary to several triggers, including drugs, which account for up to 30% of all the cases of CV. Several drugs can induce CV, including some medications commonly used in dermatology, including minocycline, and several new drugs, such as anti-TNF agents. Different pathomecanisms are involved in the development of drug-induced CV, including the formation and deposition of immune complexes, the induction of neutrophil apoptosis, the formation of neoantigens between the drugs and proteins from the host, the shift of the immune response, and others. Although the diagnosis is difficult, because the clinical picture of drug-induced CV is in general indistinguishable from that of other forms of CV, it is important to recognize such entities in order to correctly manage the patient. Anamnesis, diagnostic algorithms to assess the likelihood of the association between a drug and a cutaneous reaction, skin biopsy and laboratory testing (including the search for antineutrophil cytoplasmic antibodies) are useful tools to make a diagnosis of drug-induced CV. About the therapy, while in idiopathic vasculitides the treatment is usually more aggressive and long-lasting, very often requiring a maintenance therapy with immunosuppressive drugs, in drug-induced CV the discontinuation of the suspected drug alone is usually enough to achieve complete remission, making the prognosis usually very good.

  15. Une vie active saine pour les enfants et les adolescents

    Science.gov (United States)

    2002-01-01

    De mauvais modes de vie, comme une alimentation malsaine et l’inactivité physique, sont d'importants facteurs contributifs à une augmentation de la morbidité et de la mortalité secondaires à des maladies chroniques à l’âge adulte. Depuis dix ans, on remarque une augmentation du mode de vie sédentaire et de l’obésité chez les enfants et les adolescents, tant en Amérique du Nord qu’ailleurs dans le monde. Les médecins doivent être conscients de l’importance du problème, fournir des conseils de prévention aux familles et promouvoir une vie active saine dans leur pratique.

  16. ["Les Impatients": expression through art].

    Science.gov (United States)

    Lamontagne, Céline; Palardy, Lorraine

    2015-01-01

    The organization called "Les Impatients" was founded in 1992. Using a unique model, Les Impatients welcomes those with mental health issues who would like to express themselves through art. Les Impatients offers free creative workshops and encourages exchanges with the community through the sharing of its participants' creations. The name Les Impatients reinforces the idea that the organization does not consider those attending its workshops as patients, but rather creators who are eager to heal, develop their craft and find their place in society. The participants contribute to the collective objective of breaking down the stigma that surrounds mental illness.Les Impatients collaborates with various mental health organizations in Quebec, such as the Institut universitaire en santé mentale de Montréal (IUSMM) affiliated to the Université de Montréal, Douglas Mental Health University Institute (DMHUI), the Centre de santé et services sociaux Drummond (CSSS Drummond) and the Centre de santé et services sociaux Pierre-Boucher (CSSS Pierre-Boucher). Les Impatients offers more than 48 workshops in eight different locations to around 450 participants each week.Dissemination activities, remarkable events, original projects: Les Impatients stands out through its realizations. Examples are exhibitions, collections of love letters, comic books, CD, concerts, and reading nights. The organization's originality resides in the exploration of the links between the work of the participants and that of professional artists. An illustration of this interest is the annual Parle-moi d'amour auction-exhibition, which has been one of Les Impatients' major events since 1999.As part of its mission, Les Impatients conserves the works of art created by the participants during the workshops. Its collection includes more than 15,000 works of art from Les Impatients as well as pieces donated by collectors of unconventional art, commonly known as "art brut" or "outsider art". The

  17. Max Planck et les quanta

    CERN Document Server

    Boudenot, Jean-Claude

    2016-01-01

    « Les atomes, dit Jean Perrin en 1913, ne sont pas ces éléments éternels et insécables dont l'irréductible simplicité donnait au possible une borne, et, dans leur inimaginable petitesse, nous commençons à pressentir un fourmillement prodigieux de mondes nouveaux ». C'est bien dans un monde totalement nouveau, le monde quantique, que nous a fait pénétrer la découverte des quanta par Max Planck. Son article de 1900 est le déclencheur de l'une des plus grandes révolutions scientifiques de tous les temps. Les trente années qui suivent sont les plus riches de la physique ; Planck, Einstein, Bohr, Sommerfeld, de Broglie, Schrödinger, Heisenberg, Dirac, Born, Pauli… reconstruisent la physique sur de nouvelles bases sur fond de conflit des générations. Le monde est par ailleurs secoué par la guerre, Max Planck est tourmenté et vit des épreuves personnelles dramatiques. C'est l'homme, aussi bien que l'oeuvre, que les auteurs ont tenté de dépeindre dans cet ouvrage. Ils ont également souhait�...

  18. Cutaneous findings in five cases of malaria

    Directory of Open Access Journals (Sweden)

    Jignesh B Vaishnani

    2011-01-01

    Full Text Available Malaria is an infectious disease caused by protozoa of the genus Plasmodium. Cutaneous lesions in malaria are rarely reported and include urticaria, angioedema, petechiae, purpura, and disseminated intravascular coagulation (DIC. Here, five malaria cases associated with cutaneous lesions have been described. Out of the five cases of malaria, two were associated with urticaria and angioedema, one case was associated with urticaria, and other two were associated with reticulated blotchy erythema with petechiae. Most of the cutaneous lesions in malaria were nonspecific and reflected the different immunopathological mechanism in malarial infection.

  19. [Niacin deficiency and cutaneous immunity].

    Science.gov (United States)

    Ikenouchi-Sugita, Atsuko; Sugita, Kazunari

    2015-01-01

    Niacin, also known as vitamin B3, is required for the synthesis of coenzymes, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Niacin binds with G protein-coupled receptor (GPR) 109A on cutaneous Langerhans cells and causes vasodilation with flushing in head and neck area. Niacin deficiency due to excessive alcohol consumption, certain drugs or inadequate uptake in diet causes pellagra, a photosensitivity dermatitis. Recently several studies have revealed the mechanism of photosensitivity in niacin deficiency, which may pave a way for new therapeutic approaches. The expression level of prostaglandin E synthase (PTGES) is up-regulated in the skin of both pellagra patients and niacin deficient pellagra mouse models. In addition, pellagra is mediated through prostaglandin E₂-EP4 (PGE₂-EP4) signaling via reactive oxygen species (ROS) production in keratinocytes. In this article, we have reviewed the role of niacin in immunity and the mechanism of niacin deficiency-induced photosensitivity.

  20. Occupationally Acquired American Cutaneous Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Maria Edileuza Felinto de Brito

    2012-01-01

    Full Text Available We report two occupationally acquired cases of American cutaneous leishmaniasis (ACL: one accidental laboratory autoinoculation by contaminated needlestick while handling an ACL lesion sample, and one acquired during field studies on bird biology. Polymerase chain reaction (PCR assays of patient lesions were positive for Leishmania, subgenus Viannia. One isolate was obtained by culture (from patient 2 biopsy samples and characterized as Leishmania (Viannia naiffi through an indirect immunofluorescence assay (IFA with species-specific monoclonal antibodies (mAbs and by multilocus enzyme electrophoresis (MLEE. Patients were successfully treated with N-methyl-glucamine. These two cases highlight the potential risks of laboratory and field work and the need to comply with strict biosafety procedures in daily routines. The swab collection method, coupled with PCR detection, has greatly improved ACL laboratory diagnosis.

  1. Cutaneous tuberculosis, tuberculosis verrucosa cutis

    Directory of Open Access Journals (Sweden)

    Nilamani Mohanty

    2014-01-01

    Full Text Available Cutaneous tuberculosis because of its variability in presentation, wider differential diagnosis, and difficulty in obtaining microbiological confirmation continues to be the most challenging to diagnose for dermatologists in developing countries. Despite the evolution of sophisticated techniques such as polymerase chain reaction (PCR and enzyme-linked-immunosorbent serologic assay (ELISA, the sensitivity of new methods are not better than the isolation of Mycobacterium tuberculosum in culture. Even in the 21 st century, we rely on methods as old as the intradermal reaction purified protein derivative standard test and therapeutic trials, as diagnostic tools. We describe a case which has been diagnosed and treated as eczema by renowned physicians for 2 years. Incisional biopsy showed the presence of well-defined granulomas and ZN staining of the biopsy specimen showed the presence of acid fast bacilli; a trial of ATT (antitubercular therapy for 6 months lead to permanent cure of the lesion.

  2. Cutaneous Scar Prevention and Management

    Science.gov (United States)

    Al-Shaqsi, Sultan; Al-Bulushi, Taimoor

    2016-01-01

    Cutaneous scarring is common after trauma, surgery and infection and occurs when normal skin tissue is replaced by fibroblastic tissue during the healing process. The pathophysiology of scar formation is not yet fully understood, although the degree of tension across the wound edges and the speed of cell growth are believed to play central roles. Prevention of scars is essential and can be achieved by attention to surgical techniques and the use of measures to reduce cell growth. Grading and classifying scars is important to determine available treatment strategies. This article presents an overview of the current therapies available for the prevention and treatment of scars. It is intended to be a practical guide for surgeons and other health professionals involved with and interested in scar management. PMID:26909210

  3. Occupationally Acquired American Cutaneous Leishmaniasis

    Science.gov (United States)

    Felinto de Brito, Maria Edileuza; Andrade, Maria Sandra; de Almeida, Éricka Lima; Medeiros, Ângela Cristina Rapela; Werkhäuser, Roberto Pereira; de Araújo, Ana Isabele Freitas; Brandão-Filho, Sinval Pinto; Paiva de Almeida, Alzira Maria; Gomes Rodrigues, Eduardo Henrique

    2012-01-01

    We report two occupationally acquired cases of American cutaneous leishmaniasis (ACL): one accidental laboratory autoinoculation by contaminated needlestick while handling an ACL lesion sample, and one acquired during field studies on bird biology. Polymerase chain reaction (PCR) assays of patient lesions were positive for Leishmania, subgenus Viannia. One isolate was obtained by culture (from patient 2 biopsy samples) and characterized as Leishmania (Viannia) naiffi through an indirect immunofluorescence assay (IFA) with species-specific monoclonal antibodies (mAbs) and by multilocus enzyme electrophoresis (MLEE). Patients were successfully treated with N-methyl-glucamine. These two cases highlight the potential risks of laboratory and field work and the need to comply with strict biosafety procedures in daily routines. The swab collection method, coupled with PCR detection, has greatly improved ACL laboratory diagnosis. PMID:23227369

  4. Treatment Approaches for Cutaneous Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Sema Aytekin

    2009-06-01

    Full Text Available Cutaneous leishmaniasis (CL is a widespread tropical infection caused by numerous different species of Leishmania protozoa. In our country, CL is due frequently to L. major and L. tropica. Its clinical presentation is extremely diverse. Treatment of CL aims to prevent mucosal invasion, to accelerate the healing of skin lesions, and avoid disfiguring scar. Local and physical treatment modalities including topical paromomycin, cryotherapy, localized controlled heat, carbon dioxide laser therapy, or pentavalant antimonals can be effective against. Intralesional antimonals are still the drug of choice may patients. WHO recommends an injection of drug under edges of the lesions and the entire lesion until the surface has blanched. Parenteral antimonials are useful for large, persistent or recurrent lesions. Combinations with other drugs such as allopurinol, pentoxifylline must be used for antimony unresponsive lesions.

  5. [Livedo-like cutaneous sarcoidosis].

    Science.gov (United States)

    Duboys, S; Cante, V; Monégier du Sorbier, C; Guillet, G

    2016-05-01

    The cutaneous signs of sarcoidosis are extremely polymorphous and may be classified under several different headings. Herein, we report the case of a 51-year-old female patient presenting bilateral livedo of the knees accompanied by systemic signs with polyarthralgia, impaired general state of health, weight loss, and a sensation of dyspnoea. Skin biopsy revealed giant-cell granuloma around the dermal vessels, with no caseous necrosis. Histopathological examination of the patient's blood vessels revealed no abnormalities. Laboratory tests showed high levels of angiotensin converting enzyme (1.5×ULN), bilateral mediastinal adenomegaly and incipient pulmonary fibrosis. Systemic sarcoidosis was diagnosed on the basis of the overall clinical and laboratory picture. The patient subsequently presented hepatic involvement and hypercalcaemia associated with the sarcoidosis; systemic corticosteroid therapy (prednisone) was initiated, with slow dose-reduction. The outcome was favourable with a return to normal laboratory values, regression of the adenomegaly and subsidence of the livedo. The literature contains reports of a number of cases of livedo heralding sarcoidosis. The majority of such cases involved young or middle-aged female patients of Asian origin presenting systemic sarcoidosis, with a high frequency of ocular and neural involvement. Livedo could be accounted for by the specific disposition of granulomas around the arterioles, resulting in disturbance of local blood flow, which was probably associated with the mechanical compression of vessels and with the micro-thrombi noted at histology. Livedo may be considered a clinical sign of cutaneous sarcoidosis. Laboratory tests to screen for sarcoidosis may be proposed in the exploration of atypical livedo. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  6. American cutaneous leishmaniasis: presentation and problems of patient management

    Directory of Open Access Journals (Sweden)

    Jeffrey D. Chulay

    1988-12-01

    Full Text Available We report our experience with the diagnosis and treatment of 60 patients with American cutaneous leishmaniasis. They were infected in Panama (55, Brazil (4 or Colombia (I. Among 35 patients with a 3 week exposure in Panama, the mean maximum incubation period was 33 days (range 4-81 days. Diagnosis was delayed an average of 93 days after onset of skin lesions, due to the patient's delay in seeking medical attention (31 days, medical personnel's delay in considering the diagnosis (45 days, and the laboratory's delay in confirming the diagnosis (17 days. Forty-four patients (73% developed ulcers typical of cutaneous leishmaniasis. Sixteen additional patients (27% had atypical macular, papular, squamous, verrucous or acneiform skin lesions that were diagnosed only because leishmanial cultures were obtained. Of the 59 patients treated with pentavalent antimonial drugs, only 34 (58% were cured after the first course of treatment. Lesions which were at least 2 cm in diameter, ulcerated, or caused by Leishmania braziliensis were less likely to be cured after a single course of treatment than were lesions smaller than 2 cm, nonulcerated or caused by Leishmania mexicana or Leishmania donovani.Relatamos nossa experiência em 60 pacientes com leishmaniose tegumentar americana diagnosticada e tratada entre 1977 e 1982. Cinqüenta e cinco pacientes foram infectados no Panamá, 4 no Brasil, e 1 na Colômbia. Entre 35 pacientes com uma exposição de 3 semanas no Panamá, a média do período de incubação foi 33 dias (limite sobre 4 e 81 dias. O diagnóstico foi feito, em média, 93 dias depois do início das lesões de pele, devido a demora do paciente em procurar o serviço médico (31 dias, a demora do médico em considerar o diagnóstico (45 dias, e a demora do laboratório em confirmar o diagnóstico (17 dias. Quarenta e quatro pacientes (73% desenvolveram úlceras típicas de leishmaniose cutânea. Porém, 16 pacientes (27% tiveram lesões de pele at

  7. Les énergies renouvelables.

    OpenAIRE

    Gautier, Henri

    2015-01-01

    Voici un livre très utile pour les béotiens qui voudraient aborder la thématique des énergies renouvelables comme introduction, mais également pour les analystes travaillant dans ce domaine comme manuel de référence. En effet, écrit par un praticien de l’énergie et un pédagogue des sciences physiques, cet ouvrage balaie le panel des énergies renouvelables actuellement disponibles en fournissant des indications techniques indispensables sur chaque solution énergétique et des repères utiles sur...

  8. Les enseignements de la catastrophe

    OpenAIRE

    Grünewald, François

    2011-01-01

    Avant le séisme, divers mécanismes de coordination internationale impliquant différentes parties prenantes (donateurs, ONG internationales et nationales, agences des Nations unies, acteurs multilatéraux, Gouvernement d’Haïti, etc.), détentrices de mandats différents avaient été mis sur pied. Même si le dialogue entre les groupes de la société civile haïtienne et les différents fora de coordination internationale ont souvent été difficiles, face à des risques naturels nombreux, des efforts ava...

  9. Cutaneous T cell lymphoma mimicking cutaneous histiocytosis: differentiation by flow cytometry.

    Science.gov (United States)

    Baines, S J; McCormick, D; McInnes, E; Dunn, J K; Dobson, J M; McConnell, I

    2000-07-01

    A two-year-old, neutered female cross-bred labrador had multiple cutaneous nodules, biopsies of which revealed pathological changes consistent with cutaneous histiocytosis. During a period of one month the dog developed multicentric lymphadenopathy, a retrobulbar mass and masses within the quadriceps and cervical muscles. Fine needle aspiration cytology of the cutaneous nodules and lymph nodes and histological examination of the cutaneous nodules and muscle masses suggested the presence of lymphoblastic lymphoma. A definitive diagnosis of CD8+ T cell lymphoma was achieved by immunophenotyping the tumour cells by flow cytometry.

  10. Comment diffuser les savoirs à travers les Alpes ?

    Directory of Open Access Journals (Sweden)

    Wolfgang Pfefferkorn

    2009-03-01

    Full Text Available CIPRA’s Future in the Alps Project aims at showcasing examples of successful implementation and successful projects in the Alps, and making available to others the extensive pool of experience and practical knowledge that lies in these projects. But how to transfer knowledge in an area of some 14 million inhabitants with several linguistic and cultural regions in which thousands of projects are carried out each year, that all kinds of players who work and life in completely different contexts are able to learn and benefit from one another? How do you go about something like that?Le projet « Avenir dans les Alpes » de la CIPRA (Commission Internationale pour la Protection des Alpes a pour objectif de présenter des exemples de réalisations et de projets réussis dans les Alpes, et de mettre à disposition du public l’ensemble de l’expérience et des connaissances pratiques acquises dans le cadre de ces projets. Cependant, comment transférer les savoirs dans une zone comptant quelque 14 millions d’habitants, composée de plusieurs régions linguistiques et culturelles dans lesquelles des milliers de projets sont menés à bien chaque année, et dont tous les acteurs, qui travaillent et vivent dans des contextes complètement différents, sont capables d’apprendre et de tirer profit les uns des autres ? Comment aborder ce genre de cas ?

  11. Cutaneous manifestations of Helicobacter cinaedi infection.

    Science.gov (United States)

    Shimizu, Satoko; Inokuma, Daisuke; Watanabe, Mika; Sakai, Toshiya; Yamamoto, Satoshi; Tsuchiya, Kikuo; Shimizu, Hiroshi

    2013-03-27

    Helicobacter cinaedi causes gastroenteritis and bacter-aemia, particularly in immunocompromised individuals. Although cellulitis is sometimes reported to accompany infection by this pathogen, the cutaneous manifestations are poorly understood. To clarify the characteristic cutaneous features, 47 cases of H. cinaedi bacteraemia experienced at Sapporo City General Hospital as nosocomial infection were retrospectively evaluated. Thirty-four percent (16 cases) of the patients showed cutaneous lesions. They all had sudden onset of erythemas accompanied by high temperature. The most common cutaneous manifestations were found to be superficial cellulitis, which results in painful erythemas or infiltrated erythematous plaques on the extremities. These skin lesions can be an early clinical indicator of H. cinaedi bacteraemia in the setting of nosocomial infection.

  12. Cutaneous anthrax cases leading compartment syndrome

    Directory of Open Access Journals (Sweden)

    Emine Parlak

    2013-12-01

    Full Text Available Bacillus anthracis is the causative agent of anthrax. Anthrax is a zoonotic disease with three clinical forms. Clinical forms are skin, gastrointestinal and inhalational anthrax. Cutaneous anthrax is 95% of the cases. Cutaneous anthrax frequently defines itself. Clinical presentation of anthrax may be severe and complicated in some cases. There may seem complications like meningitis, septic shock and compartment syndrome. Compartment Syndrome is a rare complication of cutaneous anthrax and it is life threatening. Physicians working in the endemic area should be aware of this form. In this study, three cases were shown which developed compartment syndrome following cutaneous anthrax. J Microbiol Infect Dis 2013;3(4: 214-217

  13. Cutaneous manifestations of systemic tropical parasitic diseases.

    Science.gov (United States)

    Fernandes, Neil F; Kovarik, Carrie L

    2009-01-01

    Tropical diseases continue to cause significant health problems in developing nations. An overview of illnesses with notable cutaneous findings caused by protozoans and helminthes is provided. The role of the health care provider in disease management is described.

  14. Cutaneous manifestations of dermatomyositis and their management.

    Science.gov (United States)

    Callen, Jeffrey P

    2010-06-01

    Dermatomyositis is a condition with pathognomonic and characteristic cutaneous lesions. This article describes the skin manifestations observed in patients with dermatomyositis, their differential diagnosis, their relationship to internal disease (particularly malignancy), and their management.

  15. Follicular infundibulum tumour presenting as cutaneous horn

    Directory of Open Access Journals (Sweden)

    Jayaraman M

    1996-01-01

    Full Text Available Tumour of follicular infundibulum is an organoid tumour with a plate like growth attached to the epidermis with connection from the follicular epithelium. We are reporting such a case unusually presenting as cutaneous horn.

  16. Primary cutaneous mucormycosis in trauma patients.

    Science.gov (United States)

    Johnson, P C; Satterwhite, T K; Monheit, J E; Parks, D

    1987-04-01

    Primary cutaneous mucormycosis in trauma patients has been rarely reported. We describe three cases occurring in noncompromised hosts and review the literature. Prompt diagnosis and aggressive treatment with vigorous local care and appropriate antibiotics are recommended.

  17. Les charniers en Bosnie-Herzégovine. Les crimes contre les survivants

    Directory of Open Access Journals (Sweden)

    Amor Masovic

    2005-04-01

    Full Text Available Amor Masovic, responsable de la commission de recherche des disparus en Bosnie-Herzégovine et ancien responsable de la commission pour l’échange des prisonniers pendant la guerre de 1992-1995, nous présente ensuite un tableau accablant des disparitions dans les guerres récentes en ex-Yougoslavie, et des pratiques pour faire en sorte que ceux-ci ne soient ni retrouvés ni, encore moins, identifiés (d’où des fosses communes de deux types : « primaires » –  où les corps furent enterrés initialement – et « secondaires » – où ces mêmes corps furent ré-enterrés, souvent démembrés, après avoir été déterrés pour être dispersés et moins aisés à repérer. 28 000 des 40 000 disparus ex-Yougoslaves relèvent du conflit en Bosnie et sont à 95 % des civils protégés par les conventions de Genève. Sur les 280 charniers identifiés la plupart se trouvaient à l’arrière et non sur le front et les disparitions sont datables à des périodes de non-combat. Le but de la commission est donc d’abord de retrouver et identifier les morts pour « faire savoir » et permettre le deuil (puisque la barbarisation qui a été exercée est double : contre les victimes et contre leurs familles qui ne peuvent « vivre » tant qu’elles n’ont pas de certitude. En outre, faute de disposition légale et d’une absence de droit spécifique des disparus personne ne peut être incriminé pour une disparition devant le TPIY où les « disparus » ne sont donc pas représentés. Amor Masovic tire quatre conclusions de son exposé : 1 la barbarie exprimée aujourd’hui est pour partie un résultat des manques de la justice à l’égard des crimes de guerre de la seconde guerre mondiale ; 2 la guerre contre les civils augmente en même temps qu’augmentent les dispositions internationales contre ces exactions qui restent donc purement formelles ; 3 en Bosnie, la barbarisation s’est exercée sur les corps des

  18. "Les actants, les acteurs et les figures”, de A. J. Greimas

    OpenAIRE

    Baquero Velásquez Julia Marlén

    1991-01-01

    "Les actants, les acteurs et les figures" es un artículo de carácter teórico en el cual Greimas intenta responder los siguientes interrogantes: ¿Qué se entiende por actantes, actores y figuras? ¿Cómo se diferencian unos de otros? ¿, Cómo se relacionan estos tres conceptos? ¿Qué ubicación tiene cada uno en el marco de la teoría semiótica general? No se puede decir, sin embargo, que tal información se pueda obtener en forma precisa a partir de este texto, quizá debido, por un lado, a que el art...

  19. Les plantes provoquant des dermatites de contact chez l’Homme : intérêt en médecine vétérinaire

    OpenAIRE

    Ngo Ngoc Dong, Claire

    2013-01-01

    Les dermatites de contact sont des réactions cutanées provoquées par des substances au contact de la peau. Les plantes font partie des substances souvent impliquées dans ce type d’affections. Chez l’Homme, les dermatites de contact liées aux plantes sont fréquentes et certaines sont même considérées comme des maladies professionnelles. Chez les animaux, ces dermatoses, bien que probablement sous-diagnostiquées, sont plus rarement rencontrées. Après avoir réalisé un bref récapitulatif des plan...

  20. Cutaneous Angiosarcoma of Head and Neck

    OpenAIRE

    Rita Vora; Gopikrishnan Anjaneyan; Rajat Gupta

    2014-01-01

    Cutaneous angiosarcoma is a rare aggressive tumor of capillary and lymphatic endothelial cell origin. Cutaneous angiosarcoma of the head and neck regions seems to be a distinctive neoplasm with characteristic clinicopathologic features that differ from angiosarcoma in other anatomic locations. Angiosarcoma, regardless of their setting, has a bad prognosis. We presented here a case of 80 years old male, with multiple nontender grouped purple to red hemorrhagic vesicular and bullous lesions ove...

  1. Cutaneous pseudovasculitis, antiphospholipid syndrome and obstetric misadventure.

    Science.gov (United States)

    Thayaparan, A S; Lowe, S A

    2015-09-01

    We present two women with severe obstetric complications from antiphospholipid (aPL) syndrome associated with a rare dermatological manifestation, cutaneous pseudovasculitis. Both of these women developed a rash on the palmar aspect of the hands during the post partum period, with histology consistent with microthrombotic disease, despite anticoagulation. Cutaneous pseudovasculitis appears to be a maternal manifestation of aPL coagulopathy, possibly reflecting the severity of the underlying pregnancy pathology.

  2. Cutaneous Findings in Patients with Acromegaly

    OpenAIRE

    Akoglu, Gulsen; Metin, Ahmet; Emre, Selma; Ersoy, Reyhan; Cakir, Bekir

    2014-01-01

    Background: Acromegaly is a systemic syndrome caused by overproduction of growth hormone. The syndrome affects cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems. Cutaneous manifestations of acromegaly are various, usually being the first presenting findings of the disease. Methods: Dermatological examinations of 49 patients of acromegaly who were followed-up at a tertiary referral hospital.Results: The study included 27 (55.1%) female and 22 (44.9%) male patients. The on...

  3. Uncommon cutaneous manifestations of lupus erythematosus.

    Science.gov (United States)

    Mascaro, J M; Herrero, C; Hausmann, G

    1997-01-01

    Cutaneous manifestations of lupus erythematosus (LE) are, usually, characteristic enough to permit an easy diagnosis. However, some patients may present less typical lesions, associated or not to the classic ones. Therefore, irrespectively of the variety of LE (acute, subacute and chronic), in absence of the typical butterfly rash, erythematosquamous papules or plaques, or any of the characteristic cutaneous alterations, it is important (even though not always easy) to recognize the uncommon and/or atypical changes of the skin.

  4. Cutaneous leismaniasis with unusual appearance: Case report

    OpenAIRE

    Havva Erdem; İlteriş Oğuz Topal; Ümran Yıldırım

    2009-01-01

    Leishmaniasis, is a disease that is transmitted by infected sand flies when they suck the blood of mammals. It is estimated that more than 1.5 million new cutaneous leishmaniasis (CL) cases occur throughout the world every year and the disease is endemic in southern and southeastern Turkey. Cutaneous leishmaniasis presents a spectrum of manifestations both clinically and histologically. As is in our case, histopathology can be more important than clinical examination.The diagnosis is made by ...

  5. La guitare dans les musiques traditionnelles

    OpenAIRE

    Rougier, Thierry

    2002-01-01

    International audience; Ce que l'organologie classique désigne sous le nom de "guitare" connaît en fait une très grande variété (de forme, d'accord, de mode de jeu) dans les musiques traditionnelles. L'ethnomusicologie rend compte de la continuité entre les cordophones de type guitare, les autres cordophones et les instruments à percussion, sur de nombreux terrains (dans la musique flamenca, brésilienne...)

  6. Cutaneous mechanisms of isometric ankle force control.

    Science.gov (United States)

    Choi, Julia T; Lundbye-Jensen, Jesper; Leukel, Christian; Nielsen, Jens Bo

    2013-07-01

    The sense of force is critical in the control of movement and posture. Multiple factors influence our perception of exerted force, including inputs from cutaneous afferents, muscle afferents and central commands. Here, we studied the influence of cutaneous feedback on the control of ankle force output. We used repetitive electrical stimulation of the superficial peroneal (foot dorsum) and medial plantar nerves (foot sole) to disrupt cutaneous afferent input in 8 healthy subjects. We measured the effects of repetitive nerve stimulation on (1) tactile thresholds, (2) performance in an ankle force-matching and (3) an ankle position-matching task. Additional force-matching experiments were done to compare the effects of transient versus continuous stimulation in 6 subjects and to determine the effects of foot anesthesia using lidocaine in another 6 subjects. The results showed that stimulation decreased cutaneous sensory function as evidenced by increased touch threshold. Absolute dorsiflexion force error increased without visual feedback during peroneal nerve stimulation. This was not a general effect of stimulation because force error did not increase during plantar nerve stimulation. The effects of transient stimulation on force error were greater when compared to continuous stimulation and lidocaine injection. Position-matching performance was unaffected by peroneal nerve or plantar nerve stimulation. Our results show that cutaneous feedback plays a role in the control of force output at the ankle joint. Understanding how the nervous system normally uses cutaneous feedback in motor control will help us identify which functional aspects are impaired in aging and neurological diseases.

  7. Validating LES for Jet Aeroacoustics

    Science.gov (United States)

    Bridges, James

    2011-01-01

    Engineers charged with making jet aircraft quieter have long dreamed of being able to see exactly how turbulent eddies produce sound and this dream is now coming true with the advent of large eddy simulation (LES). Two obvious challenges remain: validating the LES codes at the resolution required to see the fluid-acoustic coupling, and the interpretation of the massive datasets that result in having dreams come true. This paper primarily addresses the former, the use of advanced experimental techniques such as particle image velocimetry (PIV) and Raman and Rayleigh scattering, to validate the computer codes and procedures used to create LES solutions. It also addresses the latter problem in discussing what are relevant measures critical for aeroacoustics that should be used in validating LES codes. These new diagnostic techniques deliver measurements and flow statistics of increasing sophistication and capability, but what of their accuracy? And what are the measures to be used in validation? This paper argues that the issue of accuracy be addressed by cross-facility and cross-disciplinary examination of modern datasets along with increased reporting of internal quality checks in PIV analysis. Further, it is argued that the appropriate validation metrics for aeroacoustic applications are increasingly complicated statistics that have been shown in aeroacoustic theory to be critical to flow-generated sound.

  8. Le CERN sous les yeux

    CERN Multimedia

    Lambelet, S

    1984-01-01

    J. Grinevald, A. Gsponer, L. Hanouz et P. Lehmann sortent un livre : "la quadrature du CERN". Ils apportent une vision critique de la physique des particules et entament une réflexion sur les buts de cette science (1 page).

  9. Le clonage somatique : un état des lieux chez les bovins et les petits ruminants

    OpenAIRE

    Heyman, Yvan; Chavatte-Palmer, Pascale; Vignon, Xavier; Richard, Christophe; Renard, Jean Paul

    2005-01-01

    Parmi les récentes biotechnologies de la reproduction chez les mammifères d’élevage, le clonage par transfert de noyaux somatiques constitue un pas en avant depuis la naissance de la brebis Dolly. Cet article fait le point sur les résultats actuels obtenus dans le monde chez les bovins et les petits ruminants, les limites de la technique et les applications potentielles. L’efficacité globale du clonage (nombre de jeunes nés /nombre d’embryons reconstitués) reste encore faible (≤ 7 %), mais el...

  10. Les consequences de l'echouement de l'Amoco Cadiz" sur les peuplements algaux exploitables

    OpenAIRE

    Kaas, Raymond

    1980-01-01

    Introduction. On évalue actuellement de 6 à 16 millions de tonnes par an les quantités d'hydrocarbures qui sont rejetées à la mer. Ces pollutions proviennent d'origines différentes : les rejets chroniques liés à l'activité humaine tels les déballastages des pétroliers ou les déversements d'installations côtières de traitement de pétrole ; les rejets chroniques naturels ; les rejets accidentels comme les fuites survenant sur les têtes de puits de forage ou les accidents de pétroliers. Les déve...

  11. Les présages expliqués

    CERN Document Server

    Belly

    2015-01-01

    Extrait : ""Les Romains et les Grecs avaient emprunté aux Chaldéens la plupart des arts divinatoires : Ce que disent les caractères de l'Écriture. Ce que disent les lignes du visage. Ce que disent les traits du visage. Ce que disent les cartes, etc.""

  12. Dépigmentation cutanée cosmétique des femmes noires: résultats d’une enquête CAP à Abidjan (Côte d’Ivoire)

    Science.gov (United States)

    Kourouma, Sarah; Gbery, Ildevert Patrice; Kaloga, Mamadou; Ecra, Elidjé Joseph; Sangaré, Abdoulaye; Kouassi, Isidore Yao; Kassi, Komenan; Kouassi, Alexandre Kouamé; Yoboué, Pauline Yao

    2016-01-01

    Introduction La dépigmentation cutanée cosmétique est une pratique largement répandue chez les femmes noires en Afrique. Elle comporte de nombreuses complications bien décrites depuis des décennies. Cependant, les motivations des pratiquantes ne sont pas bien connues. Notre étude avait pour objectif d'appréhender les raisons et les motivations de ces femmes afin de pouvoir mener une action de communication en vue d'un changement de comportement. Méthodes Nous avons mené une étude transversale qui a consisté en une enquête CAP (Connaissances/Attitudes/Pratiques) au centre de Dermatologie du CHU de Treichville d'Abidjan. Les données ont été analysées par les logiciels Epi Info 3.5.1. et 6.04. Résultats Les pratiquantes étaient surtout des femmes urbaines jeunes (20-40 ans), célibataires, lettrées et professionnellement actives. La dépigmentation cutanée et ses conséquences étaient connues des femmes Cependant, elles désiraient être plus belles grâce à un teint plus clair et étaient influencées par les médias et leurs amies proches. Les complications les plus fréquemment observées étaient l'ochronose exogène et les vergetures. Les moyens de communication de proximité étaient les plus souhaités par les utilisatrices pour les aider à changer de comportement. Conclusion L'élaboration de stratégies de communication de proximité visant un changement de comportement semble nécessaire pour enrayer le phénomène de dépigmentation cosmétique des femmes à Abidjan. PMID:27795757

  13. Diabetes melutus associated with pentamidine isethionate in diffuse cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Jackson Mauricio Lopes Costa

    1995-12-01

    Full Text Available The authors report a case of a male patient from Bacabal, MA with diffuse cutaneous leishmaniasis (DCL, for at least nine years, with 168 lesions on his body. These were tumour-like nodules with some ulceratmi. He usedpentavalent antimonial (glucantime® and an association of gamma interferon plus glucantime with improvement of the lesions but relapsed later. Recently, pentamidine isethionate (pentacarinat® was given a dosage of 4mg/kg/weight/day on alternate days for 20 applications. After 3 months a similar course of 10 application was given 2 times. Later he developed diabetic signs with weight loss of 10kg, polydypsia, polyuria and xerostomia. The lower limbs lesions showed signs of activity. Blood glucose levels normalised and remain like this at moment. Attention is drawn to the fact that pentamidine isethionate should be used as a therapy option with care, obeyng rigorous laboratory controls including a glucose tolerance test.Os autores relatam o caso de um paciente procedente de Bacabal, MA, portador de leishmaniose cutânea difusa (LCD há 9 anos, apresentando um total de 168 lesões distribuídas pelo corpo, de caráter nódulo tumoral e algumas ulceradas, tendo sido submetido a tratamentos anteriores á base de antimonial pentavalente (gluc antime® e associação interferom gamma+glucantime® com melhora e posterior recidiva das lesões. Recentemente quando da utilização do medicamento isotianato de pentamidina (pentacarinat® na dose de 4mg/kg/peso/dia, aplicados 1M em dias alternados em 3 séries de 20, 10, 10 aplicações com intervalos entre as séries de 3 meses. Na evolução do tratamento desenvolveu um quadro de perda de peso 10kg, polidpsia, poliúria, xerostomia, lesões de membros inferiores com sinais de atividade. Glicemia em jejum 420mg/dl, presença de glicose e corpos cetônicos na urina. Instituída insulinoterapia houve melhora do quadro e retorno dos níveis glicêmicos permanecendo estãvel até o presente

  14. Les discours politiques. Approches interactionnistes et multimodales

    OpenAIRE

    Chanay, Hugues de Constantin de; Turbide, Olivier

    2011-01-01

    Envisager les discours politiques dans une perspective interactionniste, c’est considérer que la nature politique d’un discours s’établit en fonction de la relation instaurée entre les acteurs et auteurs de ces discours et les différentes catégories de récepteurs. Comme le rappelle Charaudeau (2005, p. 30), ce n’est pas le locuteur qui fait qu’un discours est politique, ni le contenu de son discours, ni les lieux de son expression ou les types d’activités, mais c’est la situation d’interactio...

  15. Retour sur les images d’organisations

    OpenAIRE

    Audigier, Nathalie; Boutin, Éric; Bryon-Portet, Céline; Buisson, Lysiane; Cousineau, Marie-Marthe; Cousserand, Isabelle; Dilliere-Brooks, Stéphanie; Hamel, Sylvie; Hardy, Mylène; Heller, Thomas; Laborde, Aurélie; Lagacé, Martine; Lenay Blason, Alexandra; Le Moënne, Christian; Liu, Pei

    2011-01-01

    Ce numéro 34 de Communication & Organisation est consacré aux approches communicationnelles de l’image des organisations. Les contributions portent sur des aspects théoriques de définition de l’image, sur son application aux organisations, sur des aspects plus méthodologiques, et enfin sur les enjeux critiques qui entourent les pratiques organisationnelles centrées sur l’image. Depuis les années 1970, ce sont surtout les sciences de gestion et la littérature managériale qui ont produit plusie...

  16. Choroidal Metastases From Cutaneous Melanoma.

    Science.gov (United States)

    Mercado, Carmel L; Toy, Brian C; Kistler, Henry B; Moshfeghi, Darius M

    2016-05-01

    A 92-year-old man presented with months of progressive blurry vision, worsening acutely in his right eye. He denied pain, diplopia, or photopsias. His history was significant for multiple myeloma, prostate cancer, and malignant melanoma of his right shoulder treated with local excision. He had local recurrence with hepatic metastasis of the melanoma treated with radiation and chemotherapy. On examination, his visual acuity was counting fingers in the right eye and 20/60 in the left eye. Amsler grid testing demonstrated metamorphopsia in the right eye. Fundus exam of the right and left eyes revealed multiple, elevated, pigmented choroidal lesions, with associated subretinal fluid in the right macula. This appearance is consistent with hematogenous metastasis of cutaneous malignant melanoma to the choroid and associated serous fluid-causing metamorphopsia. The patient was enrolled in a clinical trial combining plasmid IL-12 with pembrolizumab (Keytruda; Merck, Whitehouse Station, NJ). He passed away 2 months after initial presentation to our clinic. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:497.].

  17. Vaccinations against cutaneous Leishmania infection.

    Science.gov (United States)

    Kronenberg, K; Brosch, S; Von Stebut, E

    2008-04-01

    Cutaneous leishmaniasis is an endemic disease with increasing incidence, even in Europe. Recently, it has attracted more attention due to reactivation in immunocompromised hosts, e.g. in the context of HIV. Therapeutic options range from topical treatment to systemic therapy for more complex cases. A vaccine does not exist at present. Despite of several attempts, vaccine generation has proven to be difficult even though protective immunity against this obligate intracellular protozoan parasite is dependent on the development of antigen-specific CD4+ and CD8+ T cells capable of releasing IFN?. IFN?, in turn, activates phagocytic host cells to generate oxidative radicals and to eliminate the parasite. This review will describe the basic immunology leading to the development of protective immunity in infected individuals. In addition, the authors will focus on highlighting the different approaches utilized for vaccine development and describe what a efficient vaccine may consist of. Combined intensive research in the fields of basic parasitology and immunology may allow for the generation of an efficacious vaccine against this important human pathogen in the near future.

  18. [Mechanisms of cutaneous drug reactions].

    Science.gov (United States)

    Vaillant, L

    2000-06-15

    Two main mechanisms, pharmacologic and immunoallergic, are responsible for cutaneous reactions to drugs. Pharmacologic mechanisms can be predictable (overdosage, cumulative or delayed toxicity, adverse effects) or unpredictable (idiosyncratic, intolerance, or anaphylactic reaction). Immunoallergic mechanisms can be mediated by IgE (some types of urticaria and anaphylactic shock), due to circulating immune complexes (leukocytoclastic vasculitis, serum sickness-type reactions) or mediated by lymphocytes (exanthema, Lyell's syndrome, fixed pigmented erythema, photosensitization). The diagnostic work-up varies according to the causative mechanism. When the reaction is predictable, the responsible drug can be identified according to the data in the present bibliography. When the reaction is immunologic, only the chronologic sequence of events can identify the responsible drug. The risk of recurrence with an identical or related molecule also varies according to the causative mechanism. For urticaria, diagnosis and the risk of recurrence differ according to whether the cause is allergic (mediated by IgE or urticarial vasculitis) or is pharmacologic (urticaria due to aspirin or to conversion enzyme inhibitors).

  19. Two cases of cutaneous cryptococcosis.

    Science.gov (United States)

    Xiujiao, Xia; Ai'e, Xu

    2005-07-01

    We report two cases of cutaneous cryptococcosis in male patients without underlying disease. Case 1 had a granulomatous mass on his right neck, gradually enlarging for 3 months. After the mass was debrided surgically in a hospital, the incision wound gradually developed into a severe ulceration. Mycological examination revealed Cryptococcus neoformans infection. It was significant that histopathology of both pre-surgery granuloma and post-surgery ulceration revealed thick-walled spores with thick capsule. Chest X-ray revealed a shadow in the left lower lung. After treatment with amphotec for 21 days, the lesion healed. Case 2 had an approximately 2 x 2 cm solitary dull nodule on his right thigh, which had been present for 8 months. Mycological examination confirmed that the lesion was caused by C. neoformans. The patient's ratio of peripheral blood CD4(+) cell was slightly reduced. After 14 days of treatment with oral fluconazole, followed by oral itraconazole for 2 months, mycological and clinical cure were achieved. The two isolates were identified as C. neoformans var. gattii serotype C and C. neoformans var. grubii serotype A.

  20. Note sur les sur les droits de diffusion des images

    Directory of Open Access Journals (Sweden)

    André Gunthert

    2009-12-01

    Full Text Available Selon l’article L 122-5 du Code de la propriété intellectuelle : « Lorsque l’oeuvre a été divulguée, l’auteur ne peut interdire : (... les analyses et courtes citations justifiées par le caractère critique, polémique, pédagogique, scientifique ou d’information de l’oeuvre à laquelle elles sont incorporées. » La jurisprudence reconnaît aux photogrammes ou vidéogrammes de films la qualité d’extrait bref, constitutif de l’exception de citation. Dans les conditions énoncées par la loi, la public...

  1. Brûlologie et médecine légale: les victimes d’incendie

    Science.gov (United States)

    Costagliola, R.; Campana, J-P.; Costagliola, M.

    2016-01-01

    Summary Lors d’une enquête judiciaire, le médecin légiste est fréquemment requis pour examiner la victime d’incendie hospitalisée. Il doit établir un certificat descriptif des brûlures en précisant leur origine, leur gravité et le pronostic vital. L’évaluation des séquelles en vue de leur indemnisation ne peut s’effectuer qu’au terme d’une longue période de soins nécessaire à la cicatrisation. L’expertise nécessite de connaître les règles médico-légales qui permettent d’apprécier les spécificités des séquelles cutanées chez les victimes de brûlure grave. Lors de la découverte d’un cadavre sur les lieux d’un incendie, le but de l’autopsie médico-légale est de vérifier que les brûlures sont bien la cause du décès. Les lésions les plus fréquemment observées sont des brûlures graves d’origine thermique. Elles sont souvent associées à une inhalation de fumées. La carbonisation du corps étant souvent utilisée pour dissimuler un homicide, la confrontation des constatations post mortem aux données de l’enquête de police est alors indispensable. Les modifications entraînées par le feu impliquent l’utilisation d’un protocole précis pour l’identification, notamment en situation de catastrophe. PMID:28289365

  2. Hybrid LES – Review and assessment

    Indian Academy of Sciences (India)

    S Vengadesan; P Nithiarasu

    2007-10-01

    In the late eighties and up to the beginning of nineties computation of turbulent flows is mostly dominated by RANS (Reynolds Averaged Navier–Stokes Simulation) type modelling. During the last few years URANS (Unsteady RANS) and LES (Large Eddy Simulation) type of approaches have been attempted with some success. Yet, there have been many difficulties when LES is applied to practical engineering problems and to high Reynolds number flows as energy dissipating eddies become really small and mesh resolution required for a reasonably resolved LES approaches that of DNS (Direct Numerical Simulation). An alternative solution suggested was to combine RANS and LES, which in general referred to as Hybrid LES. There have been many proposals for combining RANS and LES in different ways. In this article, some of the issues involved in performing hybrid LES reported in the recent literature is briefly reviewed.

  3. Spontaneous regional heading of extensive skin lesions in diffuse cutaneous leishmaniasis (DCL

    Directory of Open Access Journals (Sweden)

    Jackson M.L. Costa

    1995-03-01

    Full Text Available The authors report a case of diffuse cutaneous leishmaniasis, with longstanding evolution and presenting with diffuse infiltrated lesions rich in amastigotes in the absence of mucosal involvement. In situ characterization with monoclonal antibodies revealed Leishmania amazonensis. Large regional lesions have presented spontaneous healing without specific therapy. Considering that DCL presents with a defect in the cellular immune response, thisfact demonstrate that this patient may develop a regional cellular immune response enough to destroy the parasites and to produce clearing of some lesions.Os autores relatam um caso de leishmaniose cutânea difusa, com longa evolução epresençade lesões infiltradas difusas ricas em amastigotas havendo ausência de envolvimento mucoso. A caracterização in situ com anticorpos monocbnais revelou Leishmania amazonensis. Durante a evolução de sua doença, extensas lesões regionais apresentaram cicatrizaçâo espontânea, Considerando que a LCD apresenta-se com um déficit na resposta imune celular, este fato demonstra que o paciente pode ter desenvolvido uma resposta imune celular regional capaz de destruir os parasitas e produzir cicatrizaçâo de algumas lesões.

  4. Leishmaniose cutanée érysipéloide: à propos d'une observation clinique

    Science.gov (United States)

    El kartouti, Abdeslam; Elbenaye, Jalal; Miloudi, Mouhcine

    2015-01-01

    Les auteurs rapportent les caractéristiques épidémiologiques et cliniques de la forme érysipéloïde de leishmaniose cutanée ainsi que ses difficultés diagnostiques et thérapeutiques. Chez une patiente âgée de 44 ans, sans antécédents, a consulté pour une tuméfaction nasale inflammatoire évoluant depuis 4 mois. L'examen clinique a révélé un placard érythémateux, infiltré centrofaciale. Une antibiothérapie avec des soins locaux quotidiens n'ont pas entraîné une amélioration, voire l'extension de lésions sous anti-inflammatoire non stéroïdiens. Le diagnostic de leishmaniose cutanée a été confirmé par le frottis cutané. Un traitement par l'antimoniate de méglumine par voie intramusculaire a été instauré à la dose de 20 mg/kg par jour avec évolution favorable. La forme érysipéloïde de leishmaniose cutanée constitue une entité rare et inhabituelle entraînant souvent un retard diagnostique. Le diagnostic repose sur l'examen parasitologique direct, la recherche de l'ADN des leishmanies par PCR et sur l'examen histologique. Et il existe plusieurs options thérapeutiques. L’évolution est généralement favorable. PMID:26405490

  5. Les bienfaits de la mondialisation

    Directory of Open Access Journals (Sweden)

    Denise Pumain

    2013-05-01

    Full Text Available Du pays qui impose un système d’échanges fondé sur l’hypothèse de l’efficacité des marchés, vient enfin une proposition de régulation des excès de l’évasion fiscale, que des officines spécialisées ont euphémisée en « optimisation ». La mesure suffira-t-elle à décourager les propositions alléchantes des paradis fiscaux et à rééquilibrer les forces entre le pouvoir des Etats et la finance spéculative ? La violence de la crise engendrée par ces excès depuis plus de cinq années, dont tant de pers...

  6. Les ennemis d'Internet

    OpenAIRE

    2015-01-01

    À l’occasion de la journée mondiale contre la cybercensure, Reporters sans frontières propose dans un second rapport annuel une cartographie globale et actualisée du phénomène, géopolitique particulière distinguant les pays « ennemis de l’Internet » de ceux « mis sous surveillance ». La liste des ennemis s’est allongée : le Bélarus et Bahrain, placés l’an passé sous surveillance, figurent désormais parmi les régimes autoritaires comme l’Arabie Saoudite, la Chine, Cuba et de façon extrême en S...

  7. Cutaneous Manifestations of Familial Transthyretin Amyloid Polyneuropathy.

    Science.gov (United States)

    Lanoue, Julien; Wei, Nancy; Gorevic, Peter; Phelps, Robert G

    2016-10-01

    Familial amyloid polyneuropathy (FAP) is a rare inherited autosomal dominant form of systemic amyloidosis, which classically presents with severe motor, sensory, and autonomic dysfunction. Cutaneous involvement does not become clinically apparent until late stage symptomatic disease and is rarely reported in modern literature. Here, the authors review the clinical and histologic cutaneous findings of FAP previously described in the literature and report on 3 patients with unique genetic mutations (Thr60Ala and Gly6Ser; Trp41Leu; Glu89Gln) for which cutaneous involvement has not previously been described. Histologically, our patients showed variable amyloid deposition in the subcutaneous adipose tissue, papillary dermis, and dermal blood vessel walls. A review of the literature suggests cutaneous transthyretin deposition is an underrecognized feature of FAP that occurs early on in disease, even before neural involvement and related symptoms as seen in one of our patients. As such, a cutaneous punch biopsy can serve as quick, easy, and relatively noninvasive diagnostic tool in suspected cases.

  8. SUSY Les Houches Accord 2

    Energy Technology Data Exchange (ETDEWEB)

    Allanach, B.; Balazs, C.; Belanger, G.; Bernhardt, M.; Boudjema, F.; Choudhury, D.; Desch, K.; Ellwanger, U.; Gambino, P.; Godbole, R.; Goto, T.; Guasch, J.; Guchait, M.; Hahn, T.; Heinemeyer, S.; Hugonie, C.; Hurth, T.; Kraml, S.; Kreiss, S.; Lykken, J.; Moortgat, F.; /Cambridge U., DAMTP /Monash U. /Annecy, LAPTH /Bonn U. /Harish-Chandra Res. Inst. /Orsay, LPT /Turin U. /INFN, Turin /Bangalore, Indian Inst. Sci. /KEK, Tsukuba /Barcelona U. /Tata Inst. /Munich, Max Planck Inst. /Cantabria Inst. of Phys. /Montpellier U. /CERN /SLAC /Edinburgh U. /Fermilab /Zurich, ETH /Southampton U.

    2007-11-08

    The Supersymmetry Les Houches Accord (SLHA) provides a universal set of conventions for conveying spectral and decay information for supersymmetry analysis problems in high energy physics. Here, we propose extensions of the conventions of the first SLHA to include various generalizations: the minimal supersymmetric standard model with violation of CP, R-parity, and flavor, as well as the simplest next-to-minimal model.

  9. SUSY Les Houches Accord 2

    Energy Technology Data Exchange (ETDEWEB)

    Allanach, B.; Balazs, C.; Belanger, G.; Bernhardt, M.; Boudjema, F.; Choudhury, D.; Desch, K.; Ellwanger, U.; Gambino, P.; Godbole, R.; Goto, T.; /Cambridge U., DAMTP /Monash U. /Annecy, LAPTH /Bonn U. /Harish-Chandra Res. Inst. /Orsay, LPT /Turin U. /INFN, Turin /Bangalore, Indian Inst. Sci. /KEK, Tsukuba /Barcelona U.

    2007-11-08

    The Supersymmetry Les Houches Accord (SLHA) [1] provides a universal set of conventions for conveying spectral and decay information for supersymmetry analysis problems in high energy physics. Here, we propose extensions of the conventions of the first SLHA to include various generalizations: the minimal supersymmetric standard model with violation of CP, R-parity, and flavor, as well as the simplest next-to-minimal model.

  10. La Tentation et les savoirs

    Directory of Open Access Journals (Sweden)

    Gisèle Séginger

    2009-01-01

    Full Text Available Malgré son inactualité apparente, La Tentation de Saint Antoine se rattache à une série de savoirs, de recherches historiques, d’interrogations qui caractérisent son époque et définissent une configuration épistémologique. Les savoirs sont impliqués à deux niveaux : dans l’organisation de la poétique de l’œuvre, dans les représentations de l’œuvre. Flaubert utilise des savoirs historiques, anthropologiques et psychiatriques qui légitiment l’organisation du texte et les déconstruit en même temps. Il invente une nouvelle forme de grotesque – le grotesque des idées – et met en abyme un questionnement sur les savoirs qui évolue de la première Tentation à celle de 1874.Despite its apparent irrelevancy to Flaubert's time, La Tentation de Saint Antoine is linked to a net of knowledge, historical research, questions that characterize a period and define an epistemological configuration. These types of knowledge are at play on two levels: in the organization of the poetics of the work and in its representations. Flaubert uses historical, anthropological and psychiatric knowledge which legitimates the organization of the text while at the same time he deconstructs this body of knowledge. Flaubert invents a new form of grotesque – the grotesque of ideas – and, in a mise-en-abyme from the first Tentation to the 1874 version, he questions these fields of knowledge.

  11. Les Rêves chez Marguerite Yourcenar

    Directory of Open Access Journals (Sweden)

    Kyeongmi Kim-Bernard

    2005-04-01

    Full Text Available Marguerite Yourcenar a publié un recueil de récits de rêves intitulé Les Songes et Les Sorts en 1938. La préface de ce texte qui registre une trentaine de récits authentiques rêvés entre 1930 et 1936, donc entre ses 28 et 33 ans, nous intéresse particulièrement par ses profondes réflexions sur la matière du rêve dont les traces se trouvent dans ses écrits, notamment romanesques. Partiellement convaincue par la théorie freudienne, elle marque clairement la différence de sa vision sur ce système d’images qu’elle souhaite ne pas être traité comme le sujet d’une analyse psychanalytique ou psychologique: elle refuse le rôle intégral du rêve qui serait, selon le fondateur de la psychanalyse, la partie submergée du défoulement psychologique, notamment celle de la libido. « Le freudisme a trop cru à l’unité du symbole.

  12. Les découvreurs

    CERN Document Server

    Boorstin, Daniel

    1986-01-01

    Sous une forme vivante, enlevée, très personnelle, Les Découvreurs raconte la plus grande épopée de l'homme : celle de sa quête pour découvrir le monde qui l'entoure. Daniel Boorstin s'écarte volontairement de la traditionnelle et fastidieuse énumération des batailles, des naissances d'empires et des grands règnes : avec lui, l'histoire de notre monde devient une féerie de découvertes et de commencements. En chaque découverte d'importance, que ce soit celle de l'Amérique par Christophe Colomb ou celle de la relativité par Einstein, il voit un épisode d'une biographie. Les héros de la saga qu'il nous raconte sont des hommes dotés d'une insatiable frénésie de connaissance et d'un courage exemplaire pour affronter l'inconnu. Daniel Boorstin nous fait découvrir sous un jour nouveau des noms familiers : Hérodote, Ptolémée, Marco Polo, Copernic, Newton, Marx, Freud, et ressuscite également quelques figures remarquables oubliées de l'histoire. Pour quelles raisons les Chinois n'ont-ils pas...

  13. Proton pump inhibitor-induced subacute cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Sandholdt, L H; Laurinaviciene, R; Bygum, Anette

    2014-01-01

    Drug-induced subacute cutaneous lupus erythematosus (SCLE) has been known in the literature since 1985 and is increasingly recognized.......Drug-induced subacute cutaneous lupus erythematosus (SCLE) has been known in the literature since 1985 and is increasingly recognized....

  14. Naevus lipomatosus cutaneous superficialis : Report of 2 cases

    Directory of Open Access Journals (Sweden)

    Thappa D

    1992-01-01

    Full Text Available Two cases of naevus lipomatosus cutaneous superficialis (NLCS are reported. One of them was a case of multiple form of NLCS while other was having cutaneous lesions resembling solitary form of NLCS.

  15. Les leaders d'opinion sur les réseaux socionumériques

    OpenAIRE

    Camille Alloing; Marie Haikel-Elsabeh

    2012-01-01

    L'une des problématiques des entreprises investissant dans les campagnes marketing sur les réseaux sociaux numériques est de déterminer une population cible qui a une capacité de diffusion et de médiatisation identifiable. Le concept de leader d'opinion semble de prime abord répondre aux caractéristiques souhaitées par les entreprises pour des actions marketing sur Internet. Seulement, les leaders d'opinions sont-ils les seuls usagers d'Internet à pouvoir influer sur les cibles de l'entrepris...

  16. The Cutaneous Ciliated Cyst in Young Male: The Possibility of Ciliated Cutaneous Eccrine Cyst

    Science.gov (United States)

    Kim, Youngjoon; Kim, Hyunjung

    2015-01-01

    Cutaneous ciliated cyst was described as a painless cyst occurring on the lower limbs of women between the ages of 15 and 30 years. The cysts are typically lined by ciliated cuboidal to columnar epithelium with pseudostratified areas and focal squamous metaplasia is occasionally present. Immunohistochemical studies have demonstrated that the cysts are PR and ER positive, similar to the epithelia of the fallopian tubes. However, outliers of cutaneous ciliated cysts, including those in male patients and in unexpected locations such as the scalp, finger, and scapular area, have been reported. Thus, some hypotheses have been proposed including the Mullerian heterotopias, ciliated metaplasia of eccrine sweat glands, and embryonic remnants of the cloacal membrane. We report a rare case of cutaneous ciliated cyst on the left shoulder of a 7-year-old boy and this is the eighth case of cutaneous ciliated cyst in male patients. Moreover, through reviewing the articles, we try to propose the classification of the cutaneous ciliated cysts into the cutaneous Mullerian cysts and the ciliated cutaneous eccrine cysts. PMID:26491452

  17. The Cutaneous Ciliated Cyst in Young Male: The Possibility of Ciliated Cutaneous Eccrine Cyst

    Directory of Open Access Journals (Sweden)

    Youngjoon Kim

    2015-01-01

    Full Text Available Cutaneous ciliated cyst was described as a painless cyst occurring on the lower limbs of women between the ages of 15 and 30 years. The cysts are typically lined by ciliated cuboidal to columnar epithelium with pseudostratified areas and focal squamous metaplasia is occasionally present. Immunohistochemical studies have demonstrated that the cysts are PR and ER positive, similar to the epithelia of the fallopian tubes. However, outliers of cutaneous ciliated cysts, including those in male patients and in unexpected locations such as the scalp, finger, and scapular area, have been reported. Thus, some hypotheses have been proposed including the Mullerian heterotopias, ciliated metaplasia of eccrine sweat glands, and embryonic remnants of the cloacal membrane. We report a rare case of cutaneous ciliated cyst on the left shoulder of a 7-year-old boy and this is the eighth case of cutaneous ciliated cyst in male patients. Moreover, through reviewing the articles, we try to propose the classification of the cutaneous ciliated cysts into the cutaneous Mullerian cysts and the ciliated cutaneous eccrine cysts.

  18. Novel Cutaneous Manifestations of Pleuroparenchymal Fibroelastosis.

    Science.gov (United States)

    Lowther, Christopher M; Morrison, Annie O; Candelario, Nicole M; Khalafbeigi, Sheva; Cockerell, Clay J

    2016-10-01

    Pleuroparenchymal fibroelastosis (PPFE) is a rare progressive disease that manifests as parenchymal fibrosis of the upper lobe and pleura. Approximately 100 cases have been reported. Cutaneous manifestations of PPFE have not previously been described. Diagnosis is dependent on histologic identification of fibrosis with atypical elastic fibers, necessitating an invasive peripheral lung wedge biopsy.A 68-year-old male with a history of pleuroparenchymal fibroelastosis presented with an asymptomatic, telangiectatic erythematous eruption on bilateral lower extremities. Biopsies demonstrated a subtle perivascular infiltrate with marked increase in atypical elastic fibers, similar to the elastosis in the patient's lungs.This is the first documented case of cutaneous manifestations in PPFE. Clinicians need to be aware that cutaneous eruptions clinically simulating telangiectasia macularis eruptiva perstans but lacking a mast cell infiltrate histologically, may have increased abnormal elastic fibers. Thus, early recognition of these lesions in patients with an undefined restrictive lung disorder, may facilitate the diagnosis of PPFE in some patients.

  19. Creation of a virtual cutaneous tissue bank

    Science.gov (United States)

    LaFramboise, William A.; Shah, Sujal; Hoy, R. W.; Letbetter, D.; Petrosko, P.; Vennare, R.; Johnson, Peter C.

    2000-04-01

    Cellular and non-cellular constituents of skin contain fundamental morphometric features and structural patterns that correlate with tissue function. High resolution digital image acquisitions performed using an automated system and proprietary software to assemble adjacent images and create a contiguous, lossless, digital representation of individual microscope slide specimens. Serial extraction, evaluation and statistical analysis of cutaneous feature is performed utilizing an automated analysis system, to derive normal cutaneous parameters comprising essential structural skin components. Automated digital cutaneous analysis allows for fast extraction of microanatomic dat with accuracy approximating manual measurement. The process provides rapid assessment of feature both within individual specimens and across sample populations. The images, component data, and statistical analysis comprise a bioinformatics database to serve as an architectural blueprint for skin tissue engineering and as a diagnostic standard of comparison for pathologic specimens.

  20. Current approach to cutaneous mastocytosis in childhood.

    Science.gov (United States)

    Tamay, Zeynep; Özçeker, Deniz

    2016-09-01

    Mastocytosis is a heterogeneous disorder characterized by clonal proliferation and accumulation of mast cells in one of more organs which may lead to different clinical pictures. Pathological increase and activation of mast cells in various tissues can cause different clinical pictures. Cutaneous mastocytosis limited to the skin is the most typical clinical picture observed in children and systemic mastocytosis is very rare in the pediatric age group. The diagnosis of cutaneous mastocytosis is based on clinical findings, but is often delayed due to lack of clinical awareness of the disease and lack of its consideration in the differential diagnosis. This article focuses on the current diagnosis, management and treatment of cutaneous mastocytosis in children in order to increase awareness about this issue.

  1. Perforin expression in feline epitheliotropic cutaneous lymphoma.

    Science.gov (United States)

    Neta, Michal; Naigamwalla, Dinaz; Bienzle, Dorothee

    2008-11-01

    Cutaneous lymphomas are uncommon in people and companion animals. The tumors can be broadly categorized into epitheliotropic and nonepitheliotropic forms, which appear to have different biological behaviors. The present case describes a feline cutaneous epitheliotropic lymphoma. Masses in a 9-year-old cat were first identified on the tail. The cat was treated with chemotherapy, but additional skin masses developed on the flank, face, and ears. Local radiation induced transient tumor regression, but eventual dissemination prompted euthanasia 13 months after initial tumor appearance. Granular lymphocytes were consistently detected on blood smears, and histologically, the tumor involved the skin and superficial subcutis. Tumor lymphocytes expressed cluster of differentiation 3 (CD3) and perforin molecules, suggestive of a cytotoxic phenotype. Location, histopathological features, and perforin expression were similar to a distinct entity in human medicine designated primary cutaneous, CD8-positive, epidermotropic, cytotoxic, T-cell lymphoma.

  2. [Current diagnosis of cutaneous lupus erythematosus].

    Science.gov (United States)

    Haust, M; Bonsmann, G; Kuhn, A

    2006-07-14

    Cutaneous lupus erythematosus (CLE) is a disease with different subtypes and the new classification system includes acute CLE (ACLE), subacute CLE (SCLE), chronic CLE (CCLE), and intermittent CLE (ICLE). The broad spectrum of skin involvement and the possibility of systemic organ manifestations at the beginning and during the course of CLE require specific diagnostic procedures. Clinical assessment of the cutaneous manifestations is necessary along with a detailed patient's history. The diagnosis of CLE is confirmed by histopathology and immunofluorescence microscopy. Selective laboratory screening and additional diagnostic procedures depending on clinical symptoms are recommended. Photoprovocation tests can be performed to assess photosensitivity in patients with CLE and to support the diagnosis. Recently, a scoring system for the activity of the cutaneous manifestations in CLE has been developed and is now evaluated in several clinical studies. In this review, the classification and the characteristic clinical criteria of the different CLE subtypes as well as the current diagnostic possibilities are emphasized.

  3. Cutaneous sarcoidosis: A rare case report

    Directory of Open Access Journals (Sweden)

    Bindu Suparna M, Joshi Shivani

    2014-07-01

    Full Text Available Sarcoidosis is a Greek word (Sarco means flesh and Eido means type or like. Cutaneous sarcoidosis occurs in up to one third of patients with systemic sarcoidosis. This disease is characterised by the presence of non – caseating epitheloid cell granulomas in the skin. Cutaneous sarcoidosis presents as a diagnostic challenge to the dermatopathologists due to its varied presentations and almost identical histologic pictures. Hence, exclusion of infectious causes and compatibility with clinical and radiologic picture serve as significant criteria to come up to a diagnosis. Sometimes; skin lesions are the first manifestation of systemic sarcoidosis. This is not a contagious or allergic disease. There is a risk of development of systemic manifestations at a later date; for which a close follow up is a must. We are presenting a case of cutaneous sarcoidosis, which later on progress to sarcoidosis with systemic manifestations.

  4. Assessment of cutaneous drug delivery using microdialysis

    DEFF Research Database (Denmark)

    Kreilgaard, Mads

    2002-01-01

    During the last decade microdialysis has been successfully applied to assess cutaneous drug delivery of numerous substances, indicating the large potential for bioequivalence/bioavailability evaluation of topical formulations. The technique has been shown to be minimally invasive and supply...... pharmacokinetic information directly in the target organ for cutaneous drug delivery with high temporal resolution without further intervention with the tissue after implantation. However, there are a few challenges that need to be addressed before microdialysis can be regarded as a generally applicable routine...... technique for cutaneous drug delivery assessments. Firstly, the technique is currently not suitable for sampling of highly lipophilic compounds and, secondly, more studies are desirable for elucidation of the variables associated with the technique to increase reproducibility. The present literature...

  5. Cutaneous leishmaniasis: diagnostic pitfall. Case report

    Directory of Open Access Journals (Sweden)

    Asmae EL Hatimi

    2014-01-01

    Full Text Available Introduction: Cutaneous Leishmaniasis is a parasitic infection encountered in our daily dermatologic practice. Case report: We present a case of 57 year-old man of Moroccan origin, with erythematous squamous and indurated plaque on the abdomen, treated as sarcoidosis with corticosteroids with no improvement. Discussion: Cutaneous Leishmaniasis is endemic in 88 countries. Aside from its classical presentation it can manifest in multiple different ways. In our case, the diagnostic of Erysipeloide Leishmaniasis was corrected on the basis of the skin smear and the histopathological examination. Our observation is particular in its clinical presentation and location. To our knowledge it is the first Moroccan case. Conclusion: Even in endemic countries it is worth reporting unusual forms and locations of Cutaneous Leishmaniasis in order to avoid inappropriate diagnosis and management.

  6. Ovarian carcinoma presenting as cutaneous nasal metastasis*

    Science.gov (United States)

    António, Ana Marta; Alves, João Vitor; Goulão, João; Bártolo, Elvira

    2016-01-01

    Metastatic ovarian cancer uncommonly presents with skin metastasis. When present, skin metastases of ovarian cancer are usually localized in the vicinity of the primary tumor. We report a case of a 58-year-old woman with a rapid growing erythematous, well-defined nodule localized on the left nasal ala. A skin biopsy was performed and histopathological and immunohistochemical findings were compatible with a cutaneous metastasis of adenocarcinoma. A systematic investigation revealed a bilateral ovarian cystadenocarcinoma associated with visceral dissemination, likely associated with nose cutaneous metastasis. We report a very uncommon case because of the presentation of ovarian carcinoma as cutaneous metastasis. To our knowledge, this atypical localization on the nose has not been described yet in the literature.

  7. Adenocarcinoma of the Rectum with Cutaneous Metastases

    Directory of Open Access Journals (Sweden)

    Nohad Hanbala

    2012-01-01

    Full Text Available Cutaneous metastases of rectal carcinoma is a rare event. It occurs in fewer than 4% of all patients with rectal cancer. When present, it typically signifies a disseminated disease with a poor prognosis. Early detection and proper diagnosis of metastatic rectal cancer can significantly alter treatment and prognosis. We report a 70-year-oldmale who underwent rectal resection with permanent colostomy for rectal adenocarcinoma since seven years. The patient recently developed multiple skin nodules, mainly in his face, scalp, and upper trunk, associated with itching. Fine needle aspiration cytology from a face nodule was done which revealed metastatic adenocarcinoma associated with severe inflammation. Cutaneous metastasis of rectaladenocarcinoma is an unusual event that presents mainly in the form of skin nodules and could be the first sign of metastasis. Early diagnosis of cutaneous metastasis in these patients is important because it can alter treatment and prognosis.

  8. Subacute cutaneous lupus erythematosus presenting as poikiloderma.

    LENUS (Irish Health Repository)

    Hughes, R

    2012-02-01

    Subacute cutaneous lupus erythematosus (SCLE) is a recognised variant of lupus erythematosus (LE), which accounts for 10-15% of all cases of cutaneous LE, occurring most commonly in young to middle-aged white women. Diagnosis is based on the detection of anti-Ro\\/SS-A antibodies in the skin and serum, characteristic clinical and histological cutaneous involvement, and relatively mild systemic involvement. Several unusual variants of SCLE have been reported including erythrodermic SCLE, SCLE with vitiligo-like lesions, acral SCLE and bullous SCLE. Poikoilodermatous SCLE is a recognised but rare variant of SCLE. There are currently only two case reports, comprising five individual cases, in the literature. We present a case of SCLE in which the main clinical findings were an extensive photodistributed poikilodermatous rash and alopecia.

  9. Cutaneous Manifestations of Systemic Lupus Erythematosus

    Science.gov (United States)

    Uva, Luís; Miguel, Diana; Pinheiro, Catarina; Freitas, João Pedro; Marques Gomes, Manuel; Filipe, Paulo

    2012-01-01

    Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient. PMID:22888407

  10. Modern radiation therapy for primary cutaneous lymphomas

    DEFF Research Database (Denmark)

    Specht, Lena; Dabaja, Bouthaina; Illidge, Tim

    2015-01-01

    Primary cutaneous lymphomas are a heterogeneous group of diseases. They often remain localized, and they generally have a more indolent course and a better prognosis than lymphomas in other locations. They are highly radiosensitive, and radiation therapy is an important part of the treatment, eit...... meetings and analysis of available evidence. The guidelines represent an agreed consensus view of the International Lymphoma Radiation Oncology Group steering committee on the use of radiation therapy in primary cutaneous lymphomas in the modern era......., either as the sole treatment or as part of a multimodality approach. Radiation therapy of primary cutaneous lymphomas requires the use of special techniques that form the focus of these guidelines. The International Lymphoma Radiation Oncology Group has developed these guidelines after multinational...

  11. Pregnancy-Associated "Cutaneous Type" Pemphigus Vulgaris.

    Science.gov (United States)

    Rangel, Javier

    2016-01-01

    The development of pemphigus, including pemphigus vulgaris (PV) and pemphigus foliaceus, during pregnancy is rare. PV manifests with mucosal and/or cutaneous erosions with flaccid bullae that are histologically characterized by suprabasilar acantholysis. In contrast, pemphigus foliaceus manifests with cutaneous-only involvement and superficial epidermal acantholysis. Enzyme-linked immunosorbent assay specific for autoantibodies against desmoglein 1 and desmoglein 3 aids in the diagnosis and differentiation between pemphigus subtypes. High-dose systemic corticosteroids are first-line agents in management of PV, yet their potential long-term use raises complex management issues associated with pregnancy and fetal risk. Here we report a rare case of cutaneous-limited PV in association with pregnancy.

  12. Cutaneous mucormycosis in advanced HIV disease.

    Science.gov (United States)

    Moreira, José; Ridolfi, Felipe; Almeida-Paes, Rodrigo; Varon, Andrea; Lamas, Cristiane C

    Angionvasive mucormycosis is an emerging fungal disease known to affect mainly diabetics or subjects with profound neutropenia. Infection usually occurs through the inhalation route, but cutaneous inoculation may occur after trauma or burns. However, mucormycosis remains unusual in HIV infection. We report a fatal case of cutaneous mucormycosis due to Rhizopus arrhizus involving the scalp following herpes zoster infection. The patient was a 42-year-old man with advanced AIDS failing on salvage antiretroviral therapy. The fungus was diagnosed on the basis of histopathology and culture. Our case emphasizes the need to consider mucormycosis in the differential diagnosis of necrotic cutaneous lesions in patients with late-stage HIV disease. Copyright © 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

  13. Cutaneous mucormycosis in advanced HIV disease

    Directory of Open Access Journals (Sweden)

    José Moreira

    Full Text Available ABSTRACT Angionvasive mucormycosis is an emerging fungal disease known to affect mainly diabetics or subjects with profound neutropenia. Infection usually occurs through the inhalation route, but cutaneous inoculation may occur after trauma or burns. However, mucormycosis remains unusual in HIV infection. We report a fatal case of cutaneous mucormycosis due to Rhizopus arrhizus involving the scalp following herpes zoster infection. The patient was a 42-year-old man with advanced AIDS failing on salvage antiretroviral therapy. The fungus was diagnosed on the basis of histopathology and culture. Our case emphasizes the need to consider mucormycosis in the differential diagnosis of necrotic cutaneous lesions in patients with late-stage HIV disease.

  14. Diagnosis of Cutaneous Leishmaniasis by Multiplex PCR

    Directory of Open Access Journals (Sweden)

    M Heiat

    2010-07-01

    Full Text Available Introduction: Annually, more than 14 million people are reported to be infected with Leishmaniasis all over the world. In Iran, this disease is seen in the form of cutaneous and visceral leishmaniasis, of which the cutaneous form is more wide spread. In recent years, cutaneous leishmaniaisis is diagnosed by PCR utilizing specific primers in order to amplify different parasite genes including ribosomal RNA genes, kinetoplast DNA or tandem repeating sequences. The aim of this research was to detect early stage cutaneous leishmaniasis using Multiplex-PCR technique. Methods: In this study, 67 samples were prepared from patients with cutaneous leishmaniasis. DNA was extracted with phenolchloroform. Each specimen was analyzed using two different pairs of PCR primers. The sensitivity of each PCR was optimized on pure Leishmania DNA prior to use for diagnosis. Two standard parasites L. major and L. tropica were used as positive control. Results: DNA amplification fragments were two 115 bp and 683 bp for AB and UL primers, respectively. The sensitivity of two primers was not equal for detection of L. major and L. tropica. The sensivity of PCR with AB primer was 35 cells, while that for UL primer was 40 cells. Conclusion: The results of this study indicate that PCR is a sensitive diagnostic assay for cutaneous leishmaniasis and could be employed as the new standard for routine diagnosis when species identification is not required. However, the ability to identify species is especially important in prognosis of the disease and in deciding appropriate therapy, especially in regions where more than one type of species and disease are seen by clinicians.

  15. Cutaneous vasculitides: Clinico-pathological correlation

    Directory of Open Access Journals (Sweden)

    Gupta Suruchi

    2009-01-01

    Full Text Available Background: Cutaneous vasculitis presents as a mosaic of clinical and histological findings. Its pathogenic mechanisms and clinical manifestations are varied. Aims: To study the epidemiological spectrum of cutaneous vasculitides as seen in a dermatologic clinic and to determine the clinico-pathological correlation. Methods: A cohort study was conducted on 50 consecutive patients clinically diagnosed as cutaneous vasculitis in the dermatology outdoor; irrespective of age, sex and duration of the disease. Based on the clinical presentation, vasculitis was classified according to modified Gilliam′s classification. All patients were subjected to a baseline workup consisting of complete hemogram, serum-creatinine levels, serum-urea, liver function tests, chest X-ray, urine (routine and microscopic examination besides antistreptolysin O titer, Mantoux test, cryoglobulin levels, antineutrophilic cytoplasmic antibodies and hepatitis B and C. Histopathological examination was done in all patients while immunofluorescence was done in 23 patients. Results: Out of a total of 50 patients diagnosed clinically as cutaneous vasculitis, 41 were classified as leukocytoclastic vasculitis, 2 as Heinoch−Schonlein purpura, 2 as urticarial vasculitis and one each as nodular vasculitis, polyarteritis nodosa and pityriasis lichenoid et varioliforme acuta. Approximately 50% of the patients had a significant drug history, 10% were attributed to infection and 10% had positive collagen workup without any overt manifestations, while 2% each had Wegener granulomatosis and cryoglobulinemia. No cause was found in 26% cases. Histopathology showed features of vasculitis in 42 patients. Only 23 patients could undergo direct immunofluorescence (DIF, out of which 17 (73.9% were positive for vasculitis. Conclusions: Leukocytoclastic vasculitis was the commonest type of vaculitis presenting to the dermatology outpatient department. The workup of patients with cutaneous vasculitis

  16. Communiquer ! les bibliothécaires, les décideurs et les journalistes

    CERN Document Server

    2010-01-01

    L'enjeu de la communication en direction des élus, des décideurs, mais aussi des journalistes, est devenu vital pour les bibliothèques : il s'agit de donner à voir aux tutelles leurs activités, de rendre intelligible leur stratégie de développement, de construire une image institutionnelle forte. De quels moyens dispose la bibliothèque pour faire la preuve du bien-fondé de son existence ? Comment communiquer en direction d'un élu municipal ou régional, d'un responsable politique de la bibliothèque ? Que peut apporter une bonne collaboration avec des journalistes, avec les partenaires naturels ou hiérarchiques au sein de l'université ou de la collectivité territoriale ? Comment utiliser à bon escient les méthodes du lobbying et du marketing, ou l'emploi des réseaux sociaux ? Voilà quelques-unes des questions abordées ici.

  17. "Les actants, les acteurs et les figures”, de A. J. Greimas

    Directory of Open Access Journals (Sweden)

    Baquero Velásquez Julia Marlén

    1991-06-01

    Full Text Available "Les actants, les acteurs et les figures" es un artículo de carácter teórico en el cual Greimas intenta responder los siguientes interrogantes: ¿Qué se entiende por actantes, actores y figuras? ¿Cómo se diferencian unos de otros? ¿, Cómo se relacionan estos tres conceptos? ¿Qué ubicación tiene cada uno en el marco de la teoría semiótica general? No se puede decir, sin embargo, que tal información se pueda obtener en forma precisa a partir de este texto, quizá debido, por un lado, a que el artículo supone el conocimiento de otros textos que especifican parte de los planteamientos del autor, y, por otro, a que Greimas en tal época no había elaborado suficientemente su teoría, sino que se encontraba construyéndola.

  18. Cutaneous metastasis from gastrointestinal adenocarcinoma of unknown primary origin.

    Science.gov (United States)

    Junqueira, Ana Lucia Ariano; Corbett, Ana Maria França; Oliveira Filho, Jayme de; Nasser, Kassila da Rosa; Haddad, Natalie Nejem; Tebet, Ana Carolina Franco

    2015-01-01

    Cutaneous metastasis is a rare manifestation of visceral malignancies that indicates primarily advanced disease. Due to its low incidence and similarity to other cutaneous lesions, it is not uncommon to have a delayed diagnosis and a shortened prognosis. We describe the case of a patient who presented with a cutaneous nodule in the sternal region as a first sign of malignancy.

  19. Problems in Cutaneous Communication from Psychophysics to Information Processing.

    Science.gov (United States)

    Gilmer, B. VonHaller; Clark, Leslie L., Ed.

    After reviewing the history of communication through the skin, this paper considers recent research into the problem of cutaneous stimulation induced both mechanically and electrically. The general demands of a cutaneous communication system are discussed, and four primary dimensions of cutaneous stimulation are summarized (locus, intensity,…

  20. Cutaneous metastasis from gastrointestinal adenocarcinoma of unknown primary origin*

    Science.gov (United States)

    Junqueira, Ana Lucia Ariano; Corbett, Ana Maria França; de Oliveira Filho, Jayme; Nasser, Kassila da Rosa; Haddad, Natalie Nejem; Tebet, Ana Carolina Franco

    2015-01-01

    Cutaneous metastasis is a rare manifestation of visceral malignancies that indicates primarily advanced disease. Due to its low incidence and similarity to other cutaneous lesions, it is not uncommon to have a delayed diagnosis and a shortened prognosis. We describe the case of a patient who presented with a cutaneous nodule in the sternal region as a first sign of malignancy. PMID:26375228

  1. Cutaneous endometriosis--Surgical presentations of a gynaecological condition.

    Science.gov (United States)

    Chiang, David T; Teh, Wan T

    2006-11-01

    Endometriosis is a common gynaecological condition; cutaneous endometriosis is a subtype of endometriosis. Although cutaneous endometriosis involving the abdominal wall is not common, preoperative diagnosis of cutaneous endometriosis can be easily mistaken for a suture granuloma, lipoma, abscess, cyst or hernia. We report two common surgical presentations of this gynaecological condition.

  2. Cutaneous malignancies in immunosuppressed organ transplant recipients.

    Science.gov (United States)

    Seda, Ivette M Sosa; Zubair, Adeel; Brewer, Jerry D

    2014-01-01

    During the past century, organ transplantation has delivered the miracle of life to more than 500,000 patients in need. Secondary malignancies have developed as an unforeseen consequence of intense immunosuppressive regimens. Cutaneous malignancies have been recognized as the most frequent cancer that arises post-transplantation. Among organ transplant recipients (OTRs), skin cancer is a substantial cause of morbidity and potential mortality. The authors discuss epidemiology and clinical presentation of cutaneous malignancies; associated risk factors; recommendation for the care of immunosuppressed OTRs, and emerging therapies on the horizon.

  3. Three eyelid localized cutaneous anthrax cases.

    Science.gov (United States)

    Esmer, Oktay; Karadag, Remzi; Bilgili, Serap Gunes; Gultepe, Bilge; Bayramlar, Huseyin; Karadag, Ayse Serap

    2014-12-01

    Anthrax is primarily seen in the developing countries, but it can be a worldwide medical concern due to bioterrorism threats. Palpebral anthrax is a rare form of cutaneous anthrax. Untreated cutaneous anthrax can be lethal. Patients with palpebral anthrax can develop complications including cicatrisation and ectropion. Thus, anthrax should be considered in differential diagnosis for patients presenting with preseptal cellulitis in high-risk regions. Herein, we report three anthrax cases (with different age) involving eyelids that were cured without any complications due to early diagnosis and treatment.

  4. Cutaneous metastases presenting as genital ulcer disease

    Directory of Open Access Journals (Sweden)

    S Vasuki

    2014-01-01

    Full Text Available Cutaneous metastasis from an internal organ malignancy is rare and as, the presenting sign of malignancy is an uncommon phenomenon. Their presence, signals a poor prognosis. We report a case of 50-year-old female who was referred to sexually transmitted diseases - out patient department, with complaints of multiple genital ulcers to rule out sexually transmitted infections. After thorough evaluation, she was found to be a case of carcinoma cervix with metastatic squamous cell carcinomatous deposits on external genitalia. This case was unique because of relatively asymptomatic nature of internal malignancy and atypical presentation of carcinoma cervix as cutaneous metastasis.

  5. Dermatoscopy in diagnosing maculopapular cutaneous mastocytosis

    Directory of Open Access Journals (Sweden)

    Popadić Mirjana

    2016-01-01

    Full Text Available The diagnosis of cutaneous mastocytosis is based on the clinical finding of the pigmented macules or papules, positive Darier's sign and a dermal infiltrate composed of mast cells that can be better visualized by the use of special stains (Giemsa or Toluidine blue. Clinical, dermatoscopic and histopathological presentations of new appearing pigmented lesions in a female patient were presented. Dermatoscopic findings of pigment network-like structure combined with parallel pigmented lines and central reddish background in a adult patient with new appearing pigmented lesions should led us to searching for cutaneous mastocytosis.

  6. Lichenoid type cutaneous hyperpigmentation induced by nebivolol.

    Science.gov (United States)

    Aslan, Abdullah Nabi; Güney, Murat Can; Akçay, Murat; Keleş, Telat; Bozkurt, Engin

    2017-04-01

    Cutaneous hyperpigmentation is a common and well-defined side effect of many drugs, such as non-steroidal anti-inflammatory drugs, beta-blockers, and tetracyclines, but to the best of our knowledge there is no case of skin discoloration related to nebivolol in the literature. Presently described is lichenoid type cutaneous hyperpigmentation in a 46-year-old female patient. Hyperpigmentation emerged 3 months after initiating use of nebivolol and resolved after cessation of drug use. It was concluded that effect emerged as result of therapeutic doses of nebivolol.

  7. Cutaneous osteosarcoma arising from a burn scar

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Min A.; Yi, Jaehyuck [Kyungpook National University, Department of Radiology, College of Medicine, Daegu (Korea, Republic of); Kyungpook National University Hospital, Department of Radiology, Daegu (Korea, Republic of); Chae, Jong Min [Kyungpook National University, Department of Pathology, College of Medicine, Daegu (Korea, Republic of)

    2017-04-15

    Tumors that develop in old burn scars are usually squamous cell carcinomas. Sarcomas have also been reported, albeit rarely. To our knowledge, there has been only one case report of an extraskeletal osteosarcoma arising in a prior burn scar reported in the English-language literature, mainly discussing the clinicopathological features. Herein, we present a case of cutaneous osteosarcoma visualized as a mineralized soft-tissue mass arising from the scar associated with a previous skin burn over the back. This seems to be the first report describing the imaging features of a cutaneous osteosarcoma from an old burn scar. (orig.)

  8. Cutaneous toxoplasmosis in an immunosuppressed dog

    Directory of Open Access Journals (Sweden)

    T.S. Oliveira

    2014-06-01

    Full Text Available A seven-year-old female spayed Schnauzer was presented with cutaneous ulcerated nodular lesions shortly after the beginning of an immunosuppressive treatment for immune-mediated hemolytic disease. Cytology was performed and a great number of neutrophils and banana-shaped organisms were observed. Biopsy showed a neutrophilic and histiocytic dermatitis and panniculitis with myriads of intralesional bradyzoites cysts and tachyzoites. PCR analysis was positive for Toxoplasma gondii and negative for Neospora caninum. Immunohistochemistry confirmed intralesional T. gondii antigens. This study reports a rare case of cutaneous toxoplasmosis in an immunosuppressed dog.

  9. Cutaneous chancroid in a visitor from Vanuatu.

    Science.gov (United States)

    McBride, William J H; Hannah, Rory C S; Le Cornec, Genevera M; Bletchly, Cheryl

    2008-05-01

    A 23-year-old woman from Vanuatu presented to an Australian hospital with a 3-week history of a non-healing ulcer on the lower leg. A swab was submitted for a multiplex polymerase chain reaction designed to investigate genital ulcerative conditions. Haemophilus ducreyi was detected and the gene product was subsequently sequenced, confirming the diagnosis of cutaneous chancroid. The lesion responded to intramuscular benzathine penicillin. This report adds further evidence that cutaneous chancroid should be considered in the evaluation of skin ulcers in the south Pacific.

  10. Cutaneous leismaniasis with unusual appearance: Case report

    Directory of Open Access Journals (Sweden)

    Havva Erdem

    2009-01-01

    Full Text Available Leishmaniasis, is a disease that is transmitted by infected sand flies when they suck the blood of mammals. It is estimated that more than 1.5 million new cutaneous leishmaniasis (CL cases occur throughout the world every year and the disease is endemic in southern and southeastern Turkey. Cutaneous leishmaniasis presents a spectrum of manifestations both clinically and histologically. As is in our case, histopathology can be more important than clinical examination.The diagnosis is made by clinical examination and histopathology as well as demonstrating the parasites in the smears obtained from the lesion .In this article, we aimed to present of CL cases with atipic appearance.

  11. Les modèles fractals en finance.

    OpenAIRE

    Idier, J.

    2011-01-01

    Pour rappeler l’apport du mathématicien Benoît Mandelbrot, connu pour la théorie des fractales élaborée dès les années 1960 et décédé le 14 octobre 2010, ce court article présente la pertinence économique de sa théorie pour la modélisation des marchés financiers, des événements extrêmes ou encore des phénomènes de contagion.

  12. La tuberculose cutanée: observation de six cas confirmés au CHU Souro SANOU (CHUSS) de Bobo-Dioulasso (Burkina Faso)

    Science.gov (United States)

    Andonaba, Jean Baptiste; Barro-Traoré, Fatou; Yaméogo, Téné; Diallo, Boukary; Korsaga-Somé, Nina; Traoré, Adama

    2013-01-01

    La localisation cutanée de la maladie tuberculeuse demeure une forme rare et représente seulement 2,1% des localisations. L'objet de cette étude est de rapporter le profil épidémiologique, anatomoclinique et évolutif des cas de tuberculose ganglio-cutanée diagnostiqués dans un CHU au Burkina Faso. La fréquence de la tuberculose cutanée est très faible au CHUSS. Six cas ont été diagnostiqués entre 2004 et 2010, soit une fréquence de un cas par an. La durée d’évolution des cas allait de deux jusqu’à dix ans avant leur diagnostic. Les lésions observées étaient: trois scrofulodermes, trois gommes, une tuberculose testiculaire associée à un mal de Pott, un cas de polyadénopathies et des cicatrices atropho-rétractiles dans la plupart des cas. Sur le plan anatomopathologique, des granulomes tuberculoïdes ont été mis en évidence dans tous les cas avec une forte réaction tuberculinique à l'IDR. Sous antituberculeux pendant six mois, l’évolution a été bonne dans tous les cas mais au prix de séquelles cutanées cicatricielles inesthétiques. Son ampleur reste peut-être encore méconnue. Le renforcement du plateau technique du CHU et une bonne collaboration interdisciplinaire contribuerait à un meilleur diagnostic et prise en charge de cette affection. PMID:24648863

  13. Les AOC dans la mondialisation

    Directory of Open Access Journals (Sweden)

    Jean-Claude Hinnewinkel

    2004-12-01

    Full Text Available Fruit du conflit plusieurs fois séculaire entre les producteurs et le négoce, le terroir vitivinicole est né de phénomènes de « distinction » qui en Bordelais donnent les « crus ». Ces terroirs de production identifiés, il fallut les faire durer, face à conjoncture, face au négoce. Les réussites les plus nettes sont le résultat d’un projet collectif dont l’AOC à la française est l’une des plus spectaculaires. Renforcer le terroir, compris comme un espace de production géré par les producteurs, devient alors une des conditions essentielles de la durabilité du système. L’avenir des AOC réside sans doute dans une meilleure gestion du conflit négoce/production par l’interprofession mais aussi (surtout ! dans un renforcement de la gestion de la production au sein de l’aire de production qu’est le terroir. L’avenir du terroir relève de la gouvernance de cette aire de production avec trois partenaires : la puissance publique (INAO, l’interprofession et le syndicat des producteurs. Se pose dès lors la question du partage des compétences et la durabilité des AOC paraît liée en grande partie à une définition claire du rôle et donc du statut des syndicats de producteurs, à une véritable gouvernance locale, seule capable de donner du sens à l’ancrage géographique des vins dits de « terroir ». Mais alors ne faut-il pas impliquer un troisième partenaire, la société locale toute entière à travers ses représentations démocratique et associative ?Resulting from century-long conflicts between producers and merchants, vineyards have developped out of "distinction" phenomenons which in the Bordeaux region gave birth to "crus" (vintages. Such identified terroirs had to be defended: the French collective AOC (Denomination of Origin project is one of the most spectacular success. The terroir, as production territory organized by producers, is one of the essential conditions for sustainability

  14. Topical treatments for cutaneous warts.

    Science.gov (United States)

    Kwok, Chun Shing; Gibbs, Sam; Bennett, Cathy; Holland, Richard; Abbott, Rachel

    2012-09-12

    Viral warts are a common skin condition, which can range in severity from a minor nuisance that resolve spontaneously to a troublesome, chronic condition. Many different topical treatments are available. To evaluate the efficacy of local treatments for cutaneous non-genital warts in healthy, immunocompetent adults and children. We updated our searches of the following databases to May 2011: the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, MEDLINE (from 2005), EMBASE (from 2010), AMED (from 1985), LILACS (from 1982), and CINAHL (from 1981). We searched reference lists of articles and online trials registries for ongoing trials. Randomised controlled trials (RCTs) of topical treatments for cutaneous non-genital warts. Two authors independently selected trials and extracted data; a third author resolved any disagreements. We included 85 trials involving a total of 8815 randomised participants (26 new studies were included in this update). There was a wide range of different treatments and a variety of trial designs. Many of the studies were judged to be at high risk of bias in one or more areas of trial design.Trials of salicylic acid (SA) versus placebo showed that the former significantly increased the chance of clearance of warts at all sites (RR (risk ratio) 1.56, 95% CI (confidence interval) 1.20 to 2.03). Subgroup analysis for different sites, hands (RR 2.67, 95% CI 1.43 to 5.01) and feet (RR 1.29, 95% CI 1.07 to 1.55), suggested it might be more effective for hands than feet.A meta-analysis of cryotherapy versus placebo for warts at all sites favoured neither intervention nor control (RR 1.45, 95% CI 0.65 to 3.23). Subgroup analysis for different sites, hands (RR 2.63, 95% CI 0.43 to 15.94) and feet (RR 0.90, 95% CI 0.26 to 3.07), again suggested better outcomes for hands than feet. One trial showed cryotherapy to be better than both placebo and SA, but only for hand warts.There was no significant difference in cure rates between

  15. Lesão muscular nos atletas

    OpenAIRE

    Barroso,Guilherme Campos; Thiele,Edilson Schwansee

    2011-01-01

    Este artigo tem por objetivo demonstrar a fisiologia, o diagnóstico e o tratamento das lesões musculares com foque nos atletas, suas demandas e expectativas. As lesões musculares estão entre as queixas mais comuns no atendimento ortopédico, ocorrendo tanto em atletas como em não atletas. Estas lesões caracterizam um desafio para os especialistas, haja vista a lenta recuperação que afasta o atleta dos treinamentos e competições, as frequentes sequelas e a recorrência das lesões. A maior parte ...

  16. Espaces de femmes dans les territoires urbains

    OpenAIRE

    Rouag Djenidi, Abla

    2012-01-01

    En Algérie, les espaces féminins étaient essentiellement les espaces domestiques de la maison traditionnelle où la femme régnait sur les activités et le groupe domestique. Les espaces publics urbains étaient des espaces masculins Nous assistons actuellement à une évolution dans la condition de la femme mais également dans sa relation à l’espace urbain qui est de plus en plus investi par la population féminine. L’espace domestique s’ouvre de plus en plus à l’homme, en restant toutefois le terr...

  17. Cutaneous necrotizing vasculitis complicating Takayasu's arteritis with a review of cutaneous manifestations.

    Science.gov (United States)

    Mousa, A R; Marafie, A A; Dajani, A I

    1985-06-01

    We report a case of a 32-year-old man with chronic active Takayasu's arteritis complicated by cutaneous necrotizing vasculitis. Symptoms of the early phase of his disease coexisted with complications of the late phase.

  18. Protection contre les radiations recommandations

    CERN Document Server

    Claude, A; Kipfer, P; Bacq, Z

    Considérations générales ; mesures de sécurité vis-à-vis des sources de rayonnement externes ; mesures de sécurité vis-à-vis des radioisotopes ; étude spéciale de la protection dans quelques cas particuliers ; mesures de sécurité vis-à-vis des neutrons ; mesures de protection pour les appareils de supervoltage ; appareils physiques de mesure et de contrôle pour la protection.

  19. Les PME en forte croissance.

    OpenAIRE

    Brun, M; F. Chai

    2012-01-01

    Les PME indépendantes en forte croissance dynamisent le tissu économique français : elles créent de nombreux emplois, contribuent significativement à l’innovation et sont particulièrement rentables lorsqu’elles parviennent à émerger. Leur développement rapide exige un mode de financement adapté : une fois parvenues à maturité, ces entreprises augmentent leur ressources propres afin d’équilibrer leur bilan, ouvrant leur capital à des investisseurs privés, particuliers ou entreprises....

  20. Les esclaves du commandant Quiquandon

    OpenAIRE

    Tymowski, Michal

    2003-01-01

    Le 10 janvier 1895, Albert Grodet, gouverneur général du Soudan français, adressa au ministère des Colonies une dépêche accusant le commandant Quiquandon, dirigeant de la région Nord-Est (Ségou), d'exploiter illégalement un domaine sur lequel travaillent 140 esclaves. À partir de ce cas particulier, l'auteur analyse les conflits qui existaient à l'époque entre l'administration civile et un groupe d'officiers soudanais. Il se demande si la possession d'esclaves par des officiers, prenant...

  1. Les écoulements fluviaux

    Directory of Open Access Journals (Sweden)

    Huguette VIVIAN

    1992-06-01

    Full Text Available Cette carte présente une image des principaux fleuves et de leurs affluents, ainsi que la situation des principales stations de mesure et des lames d’eau écoulées. Cette mesure des écoulements fluviaux, effectuée d’abord à l’aide des débits mesurés dans 400 stations hydrométriques choisies parmi les 800 du réseau national, a été éventuellement enrichie par des informations complémentaires.

  2. Diagnosis and management of cutaneous vasculitis in children.

    Science.gov (United States)

    Ting, Tracy V

    2014-04-01

    Cutaneous vasculitis in children is rare. Causes of cutaneous vasculitis are varied and are typically differentiated by the affected vessel size. A skin biopsy remains the gold standard for diagnosis but other causes for vasculitis, including systemic conditions, should be considered. This article discusses the childhood conditions commonly presenting with cutaneous vasculitis (leukocytoclastic vasculitis, cutaneous polyarteritis nodosa), biopsy recommendations and findings, and management and potential differential diagnoses, and includes a brief summary of other diseases that may include cutaneous symptoms as a constellation of other systemic findings.

  3. Effect of UV irradiation on cutaneous cicatrices

    DEFF Research Database (Denmark)

    Due, Eva; Rossen, Kristian; Sorensen, Lars Tue

    2007-01-01

    The aim of this study was to examine the effect of ultraviolet (UV) irradiation on human cutaneous cicatrices. In this randomized, controlled study, dermal punch biopsy wounds served as a wound healing model. Wounds healed by primary or second intention and were randomized to postoperative solar UV...

  4. Cutaneous sporotrichosis. Intermittent treatment (pulses) with itraconazole.

    Science.gov (United States)

    Bonifaz, Alexandro; Fierro, Leonel; Saúl, Amado; Ponce, Rosa María

    2008-01-01

    Sporotrichosis is a subcutaneous and exceptionally deep mycosis caused by a dimorphic fungus, Sporothrix schenckii. Itraconazole is a triazole derivative leading to good results in the treatment of sporotrichosis. Patients with cutaneous sporotrichosis proven with mycological tests (direct examination and culture) were enrolled. All patients underwent laboratory tests (at baseline and on a monthly basis) and received oral itraconazole 400 mg/day for one week with a 3-week break (pulses); thereafter the drug was administered as pulses until clinical and mycological cure was achieved. Five patients with sporotrichosis were enrolled, 4 with cutaneous lymphangitic form and one with fixed cutaneous form. Clinical and mycological cure was achieved in 4/5 cases (80%), with a mean number of pulses of 3.5. No patient had side effects and no laboratory test abnormalities occurred. Intermittent or pulsed itraconazole was effective in treating cutaneous sporotrichosis. It may be considered as a new treatment choice that entails an important reduction in total medication use.

  5. Multiple cutaneous histiocytosis in two dogs.

    Science.gov (United States)

    Thornton, R N; Tisdall, C J

    1988-12-01

    Two cases of canine cutaneous histiocytosis are described. Diagnosis depended on overall consideration of clinical and histopathological features of the disease, as well as its response to anti-inflammatory therapy. No aetiological agent was visible using light and electron microscopy.

  6. Fibromodulin Enhances Angiogenesis during Cutaneous Wound Healing

    Directory of Open Access Journals (Sweden)

    Zhong Zheng, PhD

    2014-12-01

    Conclusions: Altogether, we demonstrated that in addition to reducing scar formation, FMOD also promotes angiogenesis. As blood vessels organize and regulate wound healing, its potent angiogenic properties will further expand the clinical application of FMOD for cutaneous healing of poorly vascularized wounds.

  7. [Cutaneous malignant melanoma and the new drugs].

    Science.gov (United States)

    Nieweg, Omgo E; Gallegos-Hernández, José Francisco

    2015-01-01

    The treatment of cutaneous melanoma has historically been essentially surgical. Much progress has been made in this area, and the resection margins have been established based on tumour depth. Candidates are also identified for lymphadenectomy, avoiding the morbidity of the procedure in patients who do not require it. But little progress has been made in systemic treatment, since the 70's when the use of dacarbazine was introduced for the treatment of patients with tumour progression or distant metastasis, with disappointing results. Despite this, Dacarbazine has been the most used drug to the present. Three years ago, two new drugs were introduced, one of them based on the target therapy and other one in the immunotherapy, offering, with the obtained results, an alternative in the treatment of cutaneous melanoma The objectives of this article are to show the pathways of these drugs, to describe the current role of surgery in cutaneous melanoma, with the arrival of these drugs, as well as to know the therapeutic alternatives that are emerging for the cutaneous melanoma based on scientific evidence.

  8. [Female patient with cutaneous anthrax in Belgium

    NARCIS (Netherlands)

    Gyssens, I.C.J.; Weyns, D.; Kullberg, B.J.; Ursi, J.P.

    2001-01-01

    A 23-year-old Turkish woman was admitted with an infection of the left thumb. The clinical picture was typical for cutaneous anthrax. Microbiological tests confirmed the diagnosis 'infection by Bacillus anthracis'. She recovered when treated with penicillin, although later tests revealed that the ba

  9. Periorbital cellulitis due to cutaneous anthrax.

    Science.gov (United States)

    Gilliland, Grant; Starks, Victoria; Vrcek, Ivan; Gilliland, Connor

    2015-12-01

    Virgil's plague of the ancient world, Bacillus anthracis, is rare in developed nations. Unfortunately rural communities across the globe continue to be exposed to this potentially lethal bacterium. Herein we report a case of periorbital cutaneous anthrax infection in a 3-year-old girl from the rural area surrounding Harare, Zimbabwe with a brief review of the literature.

  10. Human cutaneous anthrax, Georgia 2010-2012.

    Science.gov (United States)

    Kracalik, Ian; Malania, Lile; Tsertsvadze, Nikoloz; Manvelyan, Julietta; Bakanidze, Lela; Imnadze, Paata; Tsanava, Shota; Blackburn, Jason K

    2014-02-01

    We assessed the occurrence of human cutaneous anthrax in Georgia during 2010--2012 by examining demographic and spatial characteristics of reported cases. Reporting increased substantially, as did clustering of cases near urban centers. Control efforts, including education about anthrax and livestock vaccination, can be directed at areas of high risk.

  11. Primary localised cutaneous amyloidosis - a systematic review

    DEFF Research Database (Denmark)

    Kaltoft, Britta; Schmidt, Grethe; Lauritzen, Anne Falensteen;

    2013-01-01

    Amyloidosis is defined as extracellular deposits of heterogenic, misfolded proteins, amyloid fibrils, in various tissues. The aim of our study was to review the literature and to evaluate the risk of developing systemic amyloidosis (SA) and the risk of local recurrence of primary localised...... cutaneous amyloidosis (PLCA). The method of treatment was compared to the risk of local recurrence....

  12. Cutaneous leiomyosarcoma arising in a smallpox scar

    NARCIS (Netherlands)

    Pol, Robert A.; Dannenberg, Hilde; Robertus, Jan-Lukas; van Ginkel, Robert J.

    2012-01-01

    Background: Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumour that accounts for about 2-3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. Case

  13. A rapidly enlarging cutaneous hemangioma in pregnancy.

    LENUS (Irish Health Repository)

    Ma'ayeh, Marwan

    2014-06-18

    This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient\\'s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor.

  14. Human Cutaneous Anthrax, Georgia 2010–2012

    Science.gov (United States)

    Kracalik, Ian; Malania, Lile; Tsertsvadze, Nikoloz; Manvelyan, Julietta; Bakanidze, Lela; Imnadze, Paata; Tsanava, Shota

    2014-01-01

    We assessed the occurrence of human cutaneous anthrax in Georgia during 2010–-2012 by examining demographic and spatial characteristics of reported cases. Reporting increased substantially, as did clustering of cases near urban centers. Control efforts, including education about anthrax and livestock vaccination, can be directed at areas of high risk. PMID:24447721

  15. Clinicopathological and molecular aspects of cutaneous Melanoma

    NARCIS (Netherlands)

    Bogenrieder, T.

    2009-01-01

    Clinicopathological and molecular aspects of cutaneous melanoma. Melanoma arises form the transformation of neural crest-derived melanocytes, the pigment cells of the skin, which reside in the basal layer of the epidermis. Melanoma is the deadliest form of skin cancer and one of the most aggressive

  16. A rapidly enlarging cutaneous hemangioma in pregnancy

    Directory of Open Access Journals (Sweden)

    Marwan Ma’ayeh

    2014-10-01

    Full Text Available This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient’s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor.

  17. Mefloquine in the treatment of cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Correia Dalmo

    1999-01-01

    Full Text Available Three cases of cutaneous leishmaniasis were treated orally with a mefloquine dose of 4.2mg/kg/day for six days in the Teaching Hospital of the Faculdade de Medicina do Triângulo Mineiro, Uberaba, MG, Brazil. Three weeks later a new series was repeated. No patient was cured.

  18. Cutaneous leiomyosarcoma arising in a smallpox scar

    NARCIS (Netherlands)

    Pol, Robert A.; Dannenberg, Hilde; Robertus, Jan-Lukas; van Ginkel, Robert J.

    2012-01-01

    Background: Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumour that accounts for about 2-3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. Case p

  19. Short Communications Caecilians exhibit cutaneous respiration and ...

    African Journals Online (AJOL)

    1987-10-22

    Oct 22, 1987 ... 1,06 and 54,5% of total CO2 production was eliminated cutaneously. ... reasons we examined oxygen consumption (V02), carbon dioxide ... Dierk. 1988,23(2) sample from the syringe was injected as a bolus into a gas.

  20. Primary cutaneous mucormycosis: guide to surgical management.

    Science.gov (United States)

    Losee, Joseph E; Selber, Jesse; Vega, Stephen; Hall, Caroline; Scott, Glynis; Serletti, Joseph M

    2002-10-01

    Mucormycosis is the most acute, fulminate, and fatal of all fungal infections in humans. It presents most frequently in immunocompromised patients, but can occur in healthy patients in the presence of often-insignificant trauma. Surgical management of primary cutaneous mucormycosis is almost always required. Case reports of surgical treatment for primary cutaneous mucormycosis are reported in the literature; however, the extent of debridement required for cure is unclear and no uniform plan of treatment has been suggested. To date, no clinical guidelines exist to assist the clinician in the surgical management of this disease. This article reviews the literature, reports on two clinical cases, and submits clinical guidelines designed to assist the clinician in the surgical management of primary cutaneous mucormycosis. Because of the infrequent and potentially fatal nature of the diagnosis, a high index of suspicion and a low threshold for wound biopsy must be maintained. Wound cultures are grossly inadequate and should not be relied on for a false sense of security. It is recommended that, for the early diagnosis of cutaneous mucormycosis, chemotherapy and surgical debridement of grossly necrotic tissue be performed at the earliest possible time. The debrided wound is monitored for the resolution of surrounding erythema and induration before definitive reconstruction. In the case of delayed diagnosis and/or advanced or rapidly progressive disease, surgical debridement of all involved tissue, in addition to chemotherapy, is warranted.

  1. Cutaneous anthrax in Southeast Anatolia of Turkey.

    Science.gov (United States)

    Tekin, Recep; Sula, Bilal; Devecı, Ozcan; Tekin, Alicem; Bozkurt, Fatma; Ucmak, Derya; Kaya, Şafak; Bekcibasi, Muhammed; Erkan, Mehmet Emin; Ayaz, Celal; Hosoglu, Salih

    2015-03-01

    Anthrax is a rare disease cause by Bacillus anthracis, a Gram-positive, rod-shaped endospore-forming capsuled bacterium. Anthrax is manifest in three primary forms: cutaneous, respiratory, and gastrointestinal. Cutaneous anthrax accounts for approximately 95% of all cases of anthrax in humans. In the present study, we evaluated the clinical diagnosis and treatment of cutaneous anthrax, a rare disease that nonetheless remains a serious healthcare problem in developing countries. The complete medical records of patients diagnosed with cutaneous anthrax between January 2001 and December 2012 were examined in a retrospective manner. Cutaneous anthrax was diagnosed by the identification of typical anthrax lesions and/or the presence of Gram-positive-capsuled bacillus after staining with Gram stain and methylen blue in pathology samples obtained from these lesions and the presence of characteristic scarring with a history of severe swelling, black eschar, and positive response to treatment form the basis of diagnosis in cases where cultures were negative for the presence of bacillus. A total of 58 patients were admitted to the hospital with cutaneous anthrax between January 2001 and December 2012. This included 32 (55.2%) males and 26 (44.8%) females, with an age range of 15-82 years and a mean age of 38 ± 13.8 years. The incubation period for the infection ranged between 1 and 20 d (mean 3.7 ± 1.4 d). The most common symptoms at the time of hospital referral were swelling, redness, and black eschar of the skin. The most common lesion site was the hand and fingers (41.3%). Isolated of bacteria was used to diagnose the disease in six cases (23.8%), detection of Gram-positive bacillus in samples of characteristic lesion material was used in seven (28.5%) cases, and the presence of a characteristic lesion was the sole diagnostic criteria in 45 (77.6%) cases. Treatment consisted of penicillin G (12 cases), ampicillin-sulbactam (30 cases), Cefazolin (12 cases), or

  2. Les Plantations D’alignements En Turquie

    Directory of Open Access Journals (Sweden)

    Metin SARIBAŞ

    2008-01-01

    Full Text Available L’état actuel des forets de Turquie est insuffisant pour les besoins en bois. İl est indispensable de chercher denouvelles alternatives pour enrichir les produits du bois en dehors de la source forestière. Les plantationsd’alignements peuvent etre les ressources assez abondantes.Actuellement les pays qui font les plantations d’alignements sont: France, L’İtalie, Belgique, Pays-Bas,L’Allemange, L’Angleterre, Hongrie, Turquie, Grèce; L’Iraq, L’İran, Au Japonais, Aux Etat-Unis, Au Canada,L’Argentine, Bosna -Herzégovinia, L’Avustralie, Bulgaria etc. Selon les etudes de L’İnstitut Turc de RecherchePeuplier à İzmit en Turquie, longueurs des plantations routières sont aux environs de 64000km. D’aprés Hilf(1953 en France %10; en Angletterre %30 de production du bois était à l’origine des plantations routières.Depuis longtemps on discute des inconvénients et des avantages des plantations d’alignements. A parte quelquesrares exceptions, les plantations sont donc devenues pratique, courante, confiées le plus souvent a des servicesadministratifs et lorsqu’elles ne sont pas rendues obligatoires, encoragées tout au moins par subventions, enargents ou en nature et par exemptions d’impots.Les essences utilisées dans les plantations d’alignements sont: Le Platane, L’Orme, Le Peuplier, Le Frene, LeTilleul, L’Erable, Le Sycomore, Le Robinier, L’Acacia, Le Pavia, Le Noyer, Le Carya, Le Chataigner, L’Aulne,Le Bouleau, Le Chene, Le Hetre, Le Paulownia, Aillanthe, L’Alisier, Le Charme, Le Murrier etc. Dans notrearticle on porrrait étudier le potentiel prochain en détail les plantations d’alignements actuelle et dans l’avenir.

  3. Les Fleurs bleues (R. Queneau

    Directory of Open Access Journals (Sweden)

    Séverine Manhaval

    1999-09-01

    Full Text Available Les Fleurs bleues, roman paru en 1965, propose un fascinant voyage dans le temps et dans l'espace géographique des langues, une odyssée au cœur de la problématique babélienne dont il se fait le porte-parole. Queneau joue sur les particularités linguistiques, les idiolectes et les syntaxes dans une perspective transhistorique et cosmopolite, créant un nouvel esperanto romanesque : le « néobabélien ». Toutes les langues s'interpénètrent et se correspondent, enrichissent l'écriture de l'œuvre et dévoilent peu a peu ses prolongements à la fois scientifiques et philosophiques. Queneau élabore ainsi son propre système linguistique et littéraire, dans ce laboratoire de l'arche romanesque, où la langue future est en gestation.Reprenant le flambeau de Noé, l'écrivain entraîne ses lecteurs dans une traversée du déluge qui mêle le rêve et la réalité, l'humour et la nostalgie – celle de la langue unique, la virtuosité du style et la rigueur de la composition. Le roman démantèle les frontières historiques et géographiques, faisant ainsi de Noé une nouvelle figure de l'artiste, sauveur et reconstructeur du Verbe, et chantre de l'infinie potentialité du langage. Non sans humour, son esthétique se fonde sur une dialectique de la contrainte et de la liberté, de la destruction et de la reconstruction, soutenue par un style vif et corrosif. Le conteur, le poète et le mathématicien se rejoignent et conjuguent leur sagesse dans ce roman complexe et déroutant, récit à clés d'une expérience linguistique originale et approfondie.The novel Les Fleurs bleues, which was published in 1965, is an invitation to a fascinating journey into the time and space dimensions of languages, an odyssey into the heart of the Babelian problematics which it publicizes. Queneau plays upon linguistic particularities, idiosyncrasies and syntaxes within a historical and cosmopolitan perspective, and creates a new Esperanto for the novel: the

  4. Les horloges d'Einstein

    CERN Document Server

    Galison, P L

    1999-01-01

    Dans la version traditionnelle de l'Histoire de la relativitÂ? restreinte,la reformulation par EINSTEIN de la simultanÂ?itÂ? est vue comme une intervention quasi-philosophique,rendue possible par le fait qu'il ait pris ses distances par rapport Â? la physique de l'Â?poque. D'autre part,l'emploi d'Einstein au Bureau des Brevets entre dans l'histoire comme un travail bassement quotidien, lui permettant une formation technique certes,mais peu pertinente pour son travail sur la relativitÂ?. Le confÂ?rencier montrera que,bien au contraire,le travail d'Einstein sur les brevets l'a placÂ? au beau milieu de trÂ?s riches discussions culturelles et de brevets menant Â? la synchronisation des horloges le long des voies de chemin de fer reliant les villes d'Europe centrale.Une fois que l'on a compris l'histoire des horloges synchronisÂ?es, le travail d'Einstein sur la relativitÂ? en mai 1905 brille d'un feu trÂ?s diffÂ?rent.

  5. Revenir vers les habitants, revenir sur les territoires

    Directory of Open Access Journals (Sweden)

    Élizabeth Auclair

    2011-05-01

    Full Text Available Le développement durable se voulait un projet de civilisation, mais le concept a vite été fragilisé par la suprématie des intérêts économiques, et par l’enfermement dans des préoccupations d’ordre environnemental. Dans la période de crise actuelle, on s’interroge : comment veut-on vivre ? avec quelles valeurs ? dans quelles villes et dans quels territoires? Il s’agit ici de voir comment les arts et la culture peuvent contribuer à cet objectif du « vivre ensemble ». Au-delà de positionnements opportunistes, on observe qu’une meilleure prise en compte de la culture, dans ses différentes acceptions, peut promouvoir des approches transversales, reposant sur les valeurs de solidarité, de respect de la diversité culturelle, de démocratie locale et de citoyenneté, et remettre ainsi les habitants au cœur des politiques et des projets de territoires. La recomposition du paysage culturel que l’on observe en France, notamment autour des agendas 21 de la culture et des nouveaux territoires de l’art, témoigne de la part d’artistes, élus et autres professionnels de la culture d’une volonté de travailler au plus près de la population afin de monter des projets qui remettent la culture au cœur des politiques locales.Sustainable development was supposed to be a “civilization” concept, but the power of the economic interests and the pressure of the environmental issues have fragilized the concept. With the recent world crisis, many questions now arise: we must change our model, but how do we want to live, with which values and indicators, in what kind of towns and territories? In this article we propose to analyse how cultural development can help to reach the aim of “living together”. Indeed, taking into account cultural diversity and initiating local activities enables to develop new kinds of projects with the inhabitants, and to promote essential values such as local democracy, solidarity, tolerance

  6. Les effets de la supervision et de la réglementation sur les crises bancaires

    OpenAIRE

    2006-01-01

    Dans ce papier, nous avons analysé les liens possibles entre les indicateurs de supervision, de réglementation et les crises bancaires, nous avons construit alors différents indicateurs de supervision, de réglementation pour 40 pays développés et émergents. Nous avons appliqué un modèle Logit pour déterminer les variables explicatives de supervision et de réglementation qui expliquent le plus les crises bancaires. Nous avons trouvé que lorsque le pouvoir des autorités de supervision est impor...

  7. Leishmaniose cutânea em cobaias (Cavia porcellus Cutaneous leishmaniasis in guinea pigs (Cavia porcellus

    Directory of Open Access Journals (Sweden)

    Roselene Ecco

    2000-06-01

    Full Text Available São descritos três casos de leishmaniose cutânea em cobaias (Cavia porcellus machos de dois anos de idade que eram criadas como animais de estimação. As lesões macroscópicas eram semelhantes em duas cobaias e consistiam de nódulos cutâneos ulcerados no aspecto dorsal do pavilhão auricular de ambas as orelhas. Na outra cobaia, a lesão consistia de engrossamentos irregulares na pele do escroto que apareceram após uma orquiectomia realizada dois meses antes. A histopatologia era semelhante nos três casos e consistia de acentuada dermatite granulomatosa, com ulceração e numerosas formas protozoárias amastigotas no citoplasma de macrófagos, sugestivas de Leishmania sp. A microscopia eletrônica confirmou o diagnóstico de leishmaniose.Three cases of cutaneous leishmaniasis in three two-year-old male guinea pigs (Cavia porcellus raised as pets are described. Gross lesions were similar in two of the guinea pigs and consisted of raised and ulcerated cutaneous nodules in the dorsal aspect of the pinna of both ears. In another guinea pig the lesion consisted of irregular thickenning in the skin of the scrotum which followed an orchiectomy performed two months before. Histopathology was similar in the three cases and consisted of severe diffuse granulomatous dermatitis with ulceration and numerous intrahistiocytic protozoal amastigotes resembling Leishmania sp. Electron microscopy confirmed the diagnosis of leishmaniasis.

  8. Esteróles en esponjas marinas

    Directory of Open Access Journals (Sweden)

    Carmenza Duque

    2009-07-01

    Full Text Available Esta revisión bibliográfica comprende la mayona del trabajo publicado hasta el momento sobre esteróles aislados de esponjas marinas. Estos esteróles comprenden compuestos desde Cig hasta C31 con estructuras convencionales y con estructuras novedosas (núcleo y/o cadena lateral no convencional.

  9. Les associations en milieu urbain dakarois z

    African Journals Online (AJOL)

    vue d'atteindre dans les domaines du social, de l'économique, du culturel, etc., des buts .... lorsqu' on sait l'importance de la relation de l' individu au groupe—et elle est vraiment ..... attendus peuvent concerner en droit soit exclusivement les membres, ..... notamment des coopératives (Thabitat et des GIE ayant affaire avec.

  10. Industrial Applications of LES in Mechanical Engineering

    Science.gov (United States)

    2001-08-01

    UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP013624 TITLE: Industrial Applications of LES in Mechanical Engineering DISTRIBUTION...compilation report: ADP013620 thru ADP013707 UNCLASSIFIED INDUSTRIAL APPLICATIONS OF LES IN MECHANICAL ENGINEERING CHISACHI KATO Institute of Industrial...Science University of Tokyo, Tokyo, Japan MASAYUKI KAIHO, AKIRA MANABE Mechanical Engineering Research Laboratory Hitachi LTD., Ibaraki, Japan Abstract

  11. Inquiétudes pour les emplois

    CERN Multimedia

    2002-01-01

    "Le dépassement budgétaire du LHC oblige la direction a réaliser des économies. Selon les syndicats francais et suisses, ces économies entraineraient des suppressions d'emplois, notamment chez les enterprises sous-traitantes du Cern"

  12. Anisotropic grid adaptation in LES

    Science.gov (United States)

    Toosi, Siavash; Larsson, Johan

    2016-11-01

    The modeling errors depend directly on the grid (or filter) spacing in turbulence-resolving simulations (LES, DNS, DES, etc), and are typically at least as significant as the numerical errors. This makes adaptive grid-refinement complicated, since it prevents the estimation of the local error sources through numerical analysis. The present work attempts to address this difficulty with a physics-based error-source indicator that accounts for the anisotropy in the smallest resolved scales, which can thus be used to drive an anisotropic grid-adaptation process. The proposed error indicator is assessed on a sequence of problems, including turbulent channel flow and flows in more complex geometries. The formulation is geometrically general and applicable to complex geometries.

  13. Lipides et comportement alimentaire chez les enfants

    Directory of Open Access Journals (Sweden)

    Nicklaus Sophie

    2016-05-01

    Full Text Available Cet article analyse la place des lipides dans l’alimentation des jeunes enfants. Premièrement, il montre d’une part la contribution importante que devraient avoir les lipides aux apports énergétiques totaux des enfants de moins de deux ans, en raison de leur intérêt fonctionnel dans le développement neuronal et de leur effet potentiellement protecteur d’une obésité ultérieure; d’autre part, il souligne la faible contribution des lipides aux apports énergétiques totaux chez les enfants français, d’après les estimations disponibles, avec une minorité d’enfants pour lesquels les apports en lipides sont satisfaisants. Deuxièmement, il rapporte les connaissances disponibles concernant le contrôle « sensoriel » de la consommation de lipides. Chez les nouveau-nés et les nourrissons, quelques travaux portent sur les préférences pour les lipides, et indiquent l’absence d’une préférence pour les lipides. Chez les enfants, une teneur augmentée en lipides a parfois (mais pas toujours un effet positif sur l’appréciation d’un aliment, avec souvent une teneur optimale; mais elle n’est pas associée à une consommation plus élevée de l’aliment. Des teneurs élevées en lipides ont deux effets sur les apprentissages alimentaires. Chez des enfants de moins de 3 ans, un triplement de la densité énergétique par l’ajout de lipides est associé à la mise en place d’un rassasiement conditionné pour l’aliment concerné; chez des enfants plus âgés, un doublement de la densité énergétique par l’ajout de lipides, est associé à une augmentation de l’appréciation des flaveurs associées aux versions les plus riches en lipides. Des pistes d’études complémentaires sont discutées.

  14. Interventions for cutaneous molluscum contagiosum.

    Science.gov (United States)

    van der Wouden, Johannes C; van der Sande, Renske; Kruithof, Emma J; Sollie, Annet; van Suijlekom-Smit, Lisette Wa; Koning, Sander

    2017-05-17

    Molluscum contagiosum is a common skin infection that is caused by a pox virus and occurs mainly in children. The infection usually resolves within months in people without immune deficiency, but treatment may be preferred for social and cosmetic reasons or to avoid spreading the infection. A clear evidence base supporting the various treatments is lacking.This is an update of a Cochrane Review first published in 2006, and updated previously in 2009. To assess the effects of specific treatments and management strategies, including waiting for natural resolution, for cutaneous, non-genital molluscum contagiosum in people without immune deficiency. We updated our searches of the following databases to July 2016: the Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE, Embase, and LILACS. We searched six trial registers and checked the reference lists of included studies and review articles for further references to relevant randomised controlled trials. We contacted pharmaceutical companies and experts in the field to identify further relevant randomised controlled trials. Randomised controlled trials of any treatment of molluscum contagiosum in people without immune deficiency. We excluded trials on sexually transmitted molluscum contagiosum and in people with immune deficiency (including those with HIV infection). Two review authors independently selected studies, assessed methodological quality, and extracted data from selected studies. We obtained missing data from study authors where possible. We found 11 new studies for this update, resulting in 22 included studies with a total of 1650 participants. The studies examined the effects of topical (20 studies) and systemic interventions (2 studies).Among the new included studies were the full trial reports of three large unpublished studies, brought to our attention by an expert in the field. They all provided moderate-quality evidence for a lack of effect of 5% imiquimod compared to vehicle (placebo) on

  15. Lessons from Cancer Immunoediting in Cutaneous Melanoma

    Directory of Open Access Journals (Sweden)

    Mariana Aris

    2012-01-01

    Full Text Available We will revisit the dual role of the immune system in controlling and enabling tumor progression, known as cancer immunoediting. We will go through the different phases of this phenomenon, exposing the most relevant evidences obtained from experimental models and human clinical data, with special focus on Cutaneous Melanoma, an immunogenic tumor per excellence. We will describe the different immunotherapeutic strategies employed and consider current models accounting for tumor heterogeneity. And finally, we will propose a rational discussion of the progress made and the future challenges in the therapeutics of Cutaneous Melanoma, taking into consideration that tumor evolution is the resulting from a continuous feedback between tumor cells and their environment, and that different combinatorial therapeutic approaches can be implemented according to the tumor stage.

  16. Cutaneous angiosarcoma of head and neck

    Directory of Open Access Journals (Sweden)

    Rita Vora

    2014-01-01

    Full Text Available Cutaneous angiosarcoma is a rare aggressive tumor of capillary and lymphatic endothelial cell origin. Cutaneous angiosarcoma of the head and neck regions seems to be a distinctive neoplasm with characteristic clinicopathologic features that differ from angiosarcoma in other anatomic locations. Angiosarcoma, regardless of their setting, has a bad prognosis. We presented here a case of 80 years old male, with multiple nontender grouped purple to red hemorrhagic vesicular and bullous lesions over left lower cheek and upper neck area, with bilateral cervical lymph nodes since 1 month. Computed tomography thorax showed nodular opacities in the right upper and midzones. Excisional biopsy showed characterstic "dissection of collagen" with mild nuclear atypia. Immunohistochemistry showed tumor cell positive for CD-31 and Fli-1. Patient died within 1 month of presentation.

  17. Cutaneous Manifestations of Toxoplasmosis: a Case Report

    Directory of Open Access Journals (Sweden)

    Marina Sonya

    2014-09-01

    Full Text Available Although toxoplasmosis is one of the most widely spread infections in the world, types that involve the skin are extremely rare. However, skin lesions are not specific; moreover, they are quite diverse, which makes the diagnosis of cutaneous toxoplasmosis rather difficult. Thus, differential diagnosis should include a number of other diseases. We present a case of a 43-year-old immunocompetent man with multiple livid erythematous papules and nodules with yellowish discharge that involved the skin of the body and the extremities. By using electro-chemiluminescence immunoassay, immunoglobulin G antibodies to Toxoplasma gondii were detected in the serum, confirming the diagnosis of toxoplasmosis. The treatment with pyrimethamine and trimethoprim-sulfamethoxazole led to complete resolution of skin lesions. In conclusion, although rare in the dermatological practice, cutaneous toxoplasmosis should be considered in all patients presenting with lymphadenopathy, non-specific skin eruptions, especially nodular and colliquative, blood eosinophilia and histological findigs revealing abundant eosinophilic inflitrations.

  18. Drug-induced cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Laurinaviciene, Rasa; Sandholdt, Linda Holm; Bygum, Anette

    2017-01-01

    BACKGROUND: An increasing number of drugs have been linked to drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). The recognition and management of DI-SCLE can be challenging, as the condition may be triggered by different classes of drugs after variable lengths of time. OBJECTIVES......: To determine the proportion of patients with cutaneous lupus erythematosus (CLE) whose drugs are an inducing or aggravating factor. MATERIALS & METHODS: We conducted a retrospective chart review of patients diagnosed with CLE at a dermatological department over a 21-year period. We registered clinical......, serological, and histological data with a focus on drug intake. RESULTS: Of 775 consecutive patients with a diagnosis of lupus erythematosus (LE) or suspected LE, a diagnosis of CLE could be confirmed in 448 patients. A total of 130 patients had a drug intake that could suggest DI-SCLE. In 88 cases, a drug...

  19. CUTANEOUS MANIFESTATIONS ASSOCIATED WITH DIABETES MELLITUS

    Directory of Open Access Journals (Sweden)

    Satish

    2014-09-01

    Full Text Available Diabetes mellitus (DM refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. The metabolic dysregulation associated with DM causes secondary pathophysiologic changes in multiple organ systems that impose a tremendous burden on the individual with diabetes and on the health care system. AIM: of the study was to evaluate presence and prevalence of common dermatoses in patients. 250 cases of D.M. with various cutaneous manifestations attending in and outpatient department of Dr. D. Y. Patil medical hospital were evaluated. Detailed history was taken as per proforma and patient investigated. Maximum incidence was seen between 40-70 yrs. of age and in middle class. Fungal infection constituted highest number which included dermatophytosis, candidiasis and pityriasis versicolor. No cutaneous reactions to therapy for diabetes were encountered in the present study.

  20. Focus on cutaneous and uveal melanoma specificities.

    Science.gov (United States)

    Pandiani, Charlotte; Béranger, Guillaume E; Leclerc, Justine; Ballotti, Robert; Bertolotto, Corine

    2017-04-15

    Cutaneous melanoma (CM) and uveal melanoma (UM) derive from cutaneous and uveal melanocytes that share the same embryonic origin and display the same cellular function. However, the etiopathogenesis and biological behaviors of these melanomas are very different. CM and UM display distinct landscapes of genetic alterations and show different metastatic routes and tropisms. Hence, therapeutic improvements achieved in the last few years for the treatment of CM have failed to ameliorate the clinical outcomes of patients with UM. The scope of this review is to discuss the differences in tumorigenic processes (etiologic factors and genetic alterations) and tumor biology (gene expression and signaling pathways) between CM and UM. We develop hypotheses to explain these differences, which might provide important clues for research avenues and the identification of actionable vulnerabilities suitable for the development of new therapeutic strategies for metastatic UM. © 2017 Pandiani et al.; Published by Cold Spring Harbor Laboratory Press.

  1. A cutaneous mixed tumor in a dog

    Science.gov (United States)

    WATANABE, Ken-ichi; CHAMBERS, James K.; UCHIDA, Kazuyuki; NIBE, Kazumi; USHIO, Nanako; HORIUCHI, Noriyuki; KOBAYASHI, Yoshiyasu; NAKAYAMA, Hiroyuki

    2017-01-01

    The atypical cutaneous tumor of a 9-year-old mixed breed female dog was examined. The tumor was well-demarcated and histologically composed of a trichoblastic area, tricholemmal area and apocrine glandular area. Neoplastic cells in trichoblastic area and tricholemmal area had PAS-positive granules in the cytoplasm and were positive for pan-cytokeratin, cytokeratin 5/6, 14 and 19 and p63. Neoplastic cells in trichoblastic area were also positive for cytokeratin 15 and CD34. Neoplastic cells in apocrine glandular area were positive for pan-cytokeratin and cytokeratin 7, 18 and 19. Myoepithelial cell proliferation with osteocartilaginous metaplasia was observed in this area. Since neoplastic cells showed multiphenotypic differentiation for hair follicles and apocrine glands, the present case was diagnosed as a cutaneous mixed tumor. PMID:28132963

  2. [Cutaneous tuberculosis. A study of 4 cases].

    Science.gov (United States)

    Iborra, C; Cambau, E; Lecomte, C; Grosset, J; Bricaire, F; Caumes, E

    1997-01-01

    The recent increase in the incidence of tuberculosis has led to the return of cutaneous forms of this disease. In addition, diagnosis can now be made rapidly using genoma amplification. Four cases of cutaneous tuberculosis are described in nonimmunosuppressed patients: two cases of lupus vulgaris, including one due to Mycobacterium africanum, and two others of gummas, including one associated with tuberculosis verrucosa. The diagnosis was suggested by epidemiological, clinical, histological and immunological findings and confirmed by culture of the bacilli in 3 cases and by genoma amplification in 1. These observations illustrate the difficulties encountered in determining the tuberculosis nature of skin lesions. The clinical presentation, differential diagnosis, the pathophysiology of this disease and the new interest in genoma amplification are discussed.

  3. Cutaneous mechanisms of isometric ankle force control

    DEFF Research Database (Denmark)

    Choi, Julia T; Jensen, Jesper Lundbye; Leukel, Christian

    2013-01-01

    output. We used repetitive electrical stimulation of the superficial peroneal (foot dorsum) and medial plantar nerves (foot sole) to disrupt cutaneous afferent input in 8 healthy subjects. We measured the effects of repetitive nerve stimulation on (1) tactile thresholds, (2) performance in an ankle force......-matching and (3) an ankle position-matching task. Additional force-matching experiments were done to compare the effects of transient versus continuous stimulation in 6 subjects and to determine the effects of foot anesthesia using lidocaine in another 6 subjects. The results showed that stimulation decreased...... of transient stimulation on force error were greater when compared to continuous stimulation and lidocaine injection. Position-matching performance was unaffected by peroneal nerve or plantar nerve stimulation. Our results show that cutaneous feedback plays a role in the control of force output at the ankle...

  4. Cutaneous Manifestations of Toxoplasmosis: a Case Report

    OpenAIRE

    2014-01-01

    Although toxoplasmosis is one of the most widely spread infections in the world, types that involve the skin are extremely rare. However, skin lesions are not specific; moreover, they are quite diverse, which makes the diagnosis of cutaneous toxoplasmosis rather difficult. Thus, differential diagnosis should include a number of other diseases. We present a case of a 43-year-old immunocompetent man with multiple livid erythematous papules and nodules with yellowish discharge that involved the ...

  5. Primary cutaneous amebiasis with a fatal outcome.

    Science.gov (United States)

    Al-Daraji, Wael Ismail; Husain, Ehab A; Ilyas, Mohammed; Robson, Alistair

    2008-08-01

    We report a fatal case of disseminated amebiasis in a young African woman, which initially presented with an ulcerated cutaneous lesion on the left flank. The causative organism was confirmed by examination of a wet drop preparation from the ulcer discharge and by skin biopsy. The patient was not immunosuppressed and was treated unsuccessfully with metronidazole. Postmortem examination revealed the presence of intestinal amebiasis complicated by a liver abscess.

  6. Cutaneous oxalosis after long-term hemodialysis.

    Science.gov (United States)

    Abuelo, J G; Schwartz, S T; Reginato, A J

    1992-07-01

    A 27-year-old woman undergoing long-term hemodialysis developed cutaneous calcifications on her fingers. A skin biopsy specimen showed that the deposits were calcium oxalate. To our knowledge, only one previous article has reported pathologic and crystallographic studies on calcifications of the skin resulting from dialysis oxalosis. We speculate that vitamin C supplements, liberal tea consumption, an increased serum ionized calcium concentration, and the long duration of hemodialysis contributed to the production of these deposits.

  7. Disseminated histoplasmosis with oral and cutaneous manifestations

    Directory of Open Access Journals (Sweden)

    S Vidyanath

    2013-01-01

    Full Text Available Histoplasmosis is a systemic mycotic infection caused by the dimorphic fungus, Histoplasma capsulatum. Systemic histoplasmosis has emerged as an important opportunistic infection in human immunodeficiency virus (HIV patients and those in endemic areas. Reported cases of histoplasmosis have been low in India with less than 50 cases being reported. We are reporting a case of disseminated histoplasmosis with oral and cutaneous involvement in an HIV seronegative patient.

  8. Cotation de fabrication avec les normes ISO

    CERN Document Server

    Anselmetti, Bernard

    2010-01-01

    La cotation ISO en production impose de nouvelles méthodologies pour élaborer les documents de maîtrise de la qualité géométrique des produits : les dessins de phase, du brut et d'états intermédiaires pour la conformité des pièces et les fiches de production, de réglage, de contrôle et de surveillance pour la conformité des moyens de production. Une méthode de transfert unidirectionnelle simple permet d'établir des dessins de phase en normes ISO et d'optimiser la répartition des tolérances à isocapabilité. Cette cotation est déclinée en cotation d'état intermédiaire, de production et de réglage. Une méthode tridimensionnelle est proposée pour prendre en compte les effets des défauts angulaires. Une maquette montre les fonctionnalités envisageables pour les futurs outils d'aides au tolérancement de fabrication au sein de la CFAO. De nombreux exercices illustrent les différentes démarches. Ce Manuel de tolérancement est principalement destiné aux préparateurs méthodes et aux c...

  9. Muscle metaboreceptor modulation of cutaneous active vasodilation

    Science.gov (United States)

    Crandall, C. G.; Stephens, D. P.; Johnson, J. M.

    1998-01-01

    PURPOSE: Isometric handgrip exercise in hyperthermia has been shown to reduce cutaneous vascular conductance (CVC) by inhibiting the cutaneous active vasodilator system. METHODS: To identify whether this response was initiated by muscle metaboreceptors, in seven subjects two 3-min bouts of isometric handgrip exercise in hyperthermia were performed, followed by 2 min of postexercise ischemia (PEI). An index of forearm skin blood flow (laser-Doppler flowmetry) was measured on the contralateral arm at an unblocked site and at a site at which adrenergic vasoconstrictor function was blocked via bretylium iontophoresis to reveal active cutaneous vasodilator function unambiguously. Sweat rate was measured via capacitance hygrometry, CVC was indexed from the ratio of skin blood flow to mean arterial pressure and was expressed as a percentage of maximal CVC at that site. In normothermia, neither isometric exercise nor PEI affected CVC (P > 0.05). RESULTS: The first bout of isometric handgrip exercise in hyperthermia reduced CVC at control sites and this reduction persisted through PEI (pre-exercise: 59.8 +/- 5.4, exercise: 49.8 +/- 4.9, PEI: 49.7 +/- 5.3% of maximum; both P vasodilator system, is primarily mediated by muscle metaboreceptors, whereas central command or muscle mechanoreceptors have less influence.

  10. CRYOSURGERY FOR TREATMENT OF CUTANEOUS WARTS

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    I Made Bagus Adhi Paramitha

    2013-02-01

    Full Text Available Minor surgery is a general surgical procedure that applied with minimally invasive procedures and short duration, done in a superficial or just the affected tissue.  This technique is normally only requires a local anaesthetic and only has minimal  risk or complications. There are many cases that could be dealt with minor surgery one is veruka. Veruka or known as cutaneous warts is a disease that is often complained in children and adults. Veruka being estimated to occur until over 10% in children and young adults. Largest incident occurred in range of age 12 to 16 years. Veruka occurs more frequently in women than men. The peak incidence occur of age 13 years on women and 14.5 years in males. Salicylic acid and cryosurgery therapy are two of the most frequently performed in the treatment of cutaneous warts. Salicylic acid is therapy  for cutaneous warts who recently had already started replaced by cryosurgery because it is relatively easy to do and faster recovery.  

  11. Congenital cutaneous histiocytosis in a piglet.

    Science.gov (United States)

    Hélie, P; Kiupel, M; Drolet, R

    2014-07-01

    A 2-week-old crossbred male piglet with numerous congenital, variably sized macules, plaques, and papules distributed all over the body was submitted for necropsy. Significant gross and histological lesions were restricted to the skin. On light microscopic examination, these cutaneous lesions corresponded to dermal and/or subcutaneous masses composed of spindle-shaped to round cells that multifocally contained hemosiderin; epidermotropism was not observed. Immunohistochemically, the neoplastic cells were strongly positive for CD204; moderately positive for CD163, lysozyme, and vimentin; and negative for Mac 387, α-1-antitrypsin, S-100 protein and E-cadherin; frozen tissues were not available for CD1a and CD11c. Transmission electron microscopic examination of sections from formalin-fixed tissues did not reveal Birbeck's granules. The clinical, morphological, and immunohistochemical results were consistent with a congenital cutaneous histiocytosis of non-Langerhans cell origin. The condition most resembled juvenile xanthogranuloma in humans, a generally skin-limited non-Langerhans histiocytic disorder that can be congenital. Cutaneous and/or systemic histiocytic disorders are well characterized in dogs and have been described in cats, and a case with some similarities to ours has been reported in a neonatal piglet, but this is to our knowledge the first immunohistochemically supported report of histiocytosis in the pig and congenital histiocytosis in animals.

  12. Infiltrative Cutaneous Hemangiolipoma in a Goat

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    Jessica R. Collier

    2013-01-01

    Full Text Available An approximately 4-year-old castrated male, Saanen cross goat presented to the Colorado State University Veterinary Teaching Hospital for evaluation and removal of a 22 cm × 22 cm, dark red, thickened, and crusted cutaneous lesion along the left ventrolateral thorax. An initial incisional biopsy performed approximately 8 weeks earlier was suspicious for cutaneous hemangiosarcoma. Surgical excision was deemed to be the most appropriate treatment option for this goat. A complete physical exam, complete blood count, and chemistry profile were performed and results were within normal limits. Thoracic radiographs and abdominal ultrasound were performed to rule out metastatic disease and comorbid conditions; no metastatic lesions or other abnormalities were observed. En bloc surgical excision of the affected skin was performed and the entire tissue was submitted for histopathology. A final diagnosis of cutaneous hemangiolipoma was reached upon extensive sectioning and histologic examination of the larger tissue specimen. The goat recovered well from surgery and has had no further complications up to 9 months postoperatively. To our knowledge, this is the first case report of a hemangiolipoma in a goat and surgical excision for such lesions appears to be a viable treatment method.

  13. [Cutaneous nocardiosis as an opportunistic infection].

    Science.gov (United States)

    Bogaard, H J; Erkelens, G W; Faber, W R; de Vries, P J

    2004-03-13

    A 46-year-old man who had been treated with azathioprine and budesonide for Crohn's disease for the past eight years developed a purulent skin condition on the right ring finger. Despite surgical drainage and treatment with amoxicillin and flucloxacillin, the condition spread itself over the hand and lower arm, partly per continuum and partly in jumps. The patient did not feel ill and there were no systemic symptoms. Ultimately, Nocardia asteroides was cultured from the wound and complete cure was achieved after 8 months' treatment with co-trimoxazole. Infections with Nocardia spp. are rare but may occur more often and run a more fulminant course in patients under treatment with immunosuppressants. Cutaneous nocardiosis generally has a characteristic lymphogenous spreading pattern, but an atypical picture with pustules, pyoderma, cellulitis or abscess formation is also possible. In non-cutaneous nocardiosis there is usually pneumonia or lung abscess, possibly with secondary haematogenous spread to the central nervous system or skin. Culturing Nocardia requires more time than usual but can be promoted by special culture media. Treatment of the infection with co-trimoxazole is the method of choice and is almost always successful in cases of cutaneous nocardiosis.

  14. Cutaneous leiomyosarcoma arising in a smallpox scar

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    Pol Robert A

    2012-07-01

    Full Text Available Abstract Background Cutaneous leiomyosarcoma (CLM is a very rare smooth muscle tumour that accounts for about 2–3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. Case presentation A 66-year-old man presented with a painless, slow-growing lump in a small pox scar on his left shoulder. Histological biopsies showed the lesion to be a primary, well-differentiated cutaneous leiomyosarcoma. A CT scan of the thorax was conducted, which showed no signs of metastases. The complete lesion was then surgically excised, and histopathological examination revealed a radically excised cutaneous type leiomyosarcoma After 13 months’ review the patient was doing well with no evidence of tumour recurrence. Conclusions This is the first report of a CLM arising in a small pox scar. Although the extended time interval between scarring and malignant changes makes it difficult to advise strict follow-up for patients with small pox scars, one should be aware that atypical changes and/or symptoms occurring in a small pox scar could potentially mean malignant transformation.

  15. Cutaneous leiomyosarcoma arising in a smallpox scar.

    Science.gov (United States)

    Pol, Robert A; Dannenberg, Hilde; Robertus, Jan-Lukas; van Ginkel, Robert J

    2012-07-16

    Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumour that accounts for about 2-3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. A 66-year-old man presented with a painless, slow-growing lump in a small pox scar on his left shoulder. Histological biopsies showed the lesion to be a primary, well-differentiated cutaneous leiomyosarcoma. A CT scan of the thorax was conducted, which showed no signs of metastases. The complete lesion was then surgically excised, and histopathological examination revealed a radically excised cutaneous type leiomyosarcoma After 13 months' review the patient was doing well with no evidence of tumour recurrence. This is the first report of a CLM arising in a small pox scar. Although the extended time interval between scarring and malignant changes makes it difficult to advise strict follow-up for patients with small pox scars, one should be aware that atypical changes and/or symptoms occurring in a small pox scar could potentially mean malignant transformation.

  16. Primary Cutaneous Histoplasmosis Masquerading as Lepromatous Leprosy

    Science.gov (United States)

    Rani, Poonam; Aggarwal, Radhika; Kaushal, Seema

    2017-01-01

    Histoplasmosis is a genus of dimorphic fungi having various varieties of which the commonest one causing infection is Histoplasma capsulatum known to cause histoplasmosis. It has a varied disease spectrum ranging from an acute infection to chronic disease especially in lungs, disseminated disease and cutaneous disorder. Histoplasma capsulatum usually causes subclinical infection and serious infections only manifest in immunocompromised patients. Frank cases of infection are seen in pulmonary histoplasmosis. The spores of these organisms are seen to be strongly associated with droppings of birds and bats. A combination of these droppings and some soil types provide for an excellent environment for the proliferation of spores. Pulmonary histoplasmosis and disseminated disease are very common in AIDS patients and are a great cause of morbidity and mortality in these patients. Primary cutaneous histoplasmosis is very rare and occurs due to penetrating injuries. Once diagnosis is made, the lesions respond very well to oral itraconazole, fluconazole or amphotericicn B. We report a rare case of Cutaneous Histoplasmosis (CHP) in a 70-year-old male with complaints of multiple nodules all over his body in a HIV seronegative and otherwise immunocompetent patient. PMID:28273974

  17. Cutaneous findings in patients with acromegaly.

    Science.gov (United States)

    Akoglu, Gulsen; Metin, Ahmet; Emre, Selma; Ersoy, Reyhan; Cakir, Bekir

    2013-01-01

    Acromegaly is a systemic syndrome caused by overproduction of growth hormone. The syndrome affects cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems. Cutaneous manifestations of acromegaly are various, usually being the first presenting findings of the disease. Forty-nine patients with acromegaly, followed-up at a tertiary referral hospital, underwent dermatological examination. There were 27 (55.1%) female and 22 (44.9%) male patients. The age at onset of the disease was older in females than males (P=0.045). Most patients had acral enlargements, large triangular nose, coarse face, thickened lower lip, and prognathism. Fourteen (28.6%) patients had multiple cherry angiomas, five (10.2%) had varicose veins in lower limbs, and two (4.1%) had psoriasis. In conclusion, a wide spectrum of cutaneous symptoms and features may be associated with acromegaly. Detailed dermatological examination of patients with acromegaly should be an essential component of systemic evaluation. Future prospective studies investigating the relationships between changes in skin signs, hormone levels, and response to treatments may help understand details of skin involvement in acromegaly.

  18. Chronic iritis associated with cutaneous leukocytoclastic vasculitis.

    Science.gov (United States)

    Lambert, Jessica; Rodriguez, Alexis; Pearcy-Baluyot, Mischelle; Shahi, Sanjeet K

    2015-05-01

    Cutaneous leukocytoclastic vasculitis (LCV) is a systemic condition that can be associated with iritis. LCV is characterized as a small-vessel vasculitis of the cutaneous area. The disease demonstrates purple lesions on the skin due to the destruction of small cutaneous blood vessels. These lesions are palpable and most often coalesce forming larger patches on the surface of the skin. During early stages of LCV, the disease can be undetected due to the infrequency and small size of the skin lesions. As such, the patient might go undiagnosed for years while having symptoms of LCV or iritis of unknown etiology. This article discusses the correlation seen with LCV and iritis. We report a case on a patient that presented to our clinic with a history of bilateral chronic iritis. After extensive laboratory testing, we concluded that the chronicity of her iritis was due to her LCV. The correlation between LCV and iritis was not evident for several years in our patient. We also discuss the correlation with systemic Sjogren's syndrome and LVC and how these two separate diseases are linked in many patients. We will illustrate the importance of serological testing, imaging, and skin lesion biopsy for the diagnosis of LCV.

  19. Cutaneous natural killer/T-cell lymphoma.

    Science.gov (United States)

    Radonich, Michael A; Lazova, Rossitza; Bolognia, Jean

    2002-03-01

    Lymphomas are classified as either Hodgkin's or non-Hodgkin's. The 2 subtypes of non-Hodgkin's lymphoma that can present primarily in the skin are cutaneous T-cell lymphoma and cutaneous B-cell lymphoma, both of which tend to be low-grade malignant neoplasms. Recently another distinct subtype of lymphoma was discovered, the natural killer (NK)/T-cell lymphoma, which can involve the skin in a primary or secondary fashion. The NK/T-cell subtype of lymphoma is characterized by the expression of the NK-cell antigen CD56. These CD56(+) lymphomas are further subdivided into nasal NK/T-cell lymphomas that commonly present as midfacial destructive disease and non-nasal NK/T-cell lymphomas that often arise in extranodal locations, including the skin. We report a case of aggressive NK-cell leukemia/lymphoma with numerous secondary cutaneous lesions and review the clinical and histopathologic spectrum of non-nasal CD56(+) lymphomas, with an emphasis on the dermatologic findings.

  20. Anterior cutaneous nerve entrapment syndrome: management challenges

    Directory of Open Access Journals (Sweden)

    Chrona E

    2017-01-01

    Full Text Available Eleni Chrona,1,2 Georgia Kostopanagiotou,1 Dimitrios Damigos,3 Chrysanthi Batistaki1 1Second Department of Anesthesiology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, 2Department of Anesthesiology, General Hospital of “Ag. Panteleimon,” Piraeus, 3Department of Medical Psychology, Medical School of Ioannina, University of Ioannina, Ioannina, Greece Abstract: Anterior cutaneous nerve entrapment syndrome (ACNES is a commonly underdiagnosed and undertreated chronic state of pain. This syndrome is characterized by the entrapment of the cutaneous branches of the lower thoracoabdominal intercostal nerves at the lateral border of the rectus abdominis muscle, which causes severe, often refractory, chronic pain. This narrative review aims to identify the possible therapeutic strategies for the management of the syndrome. Seventeen studies about ACNES therapy were reviewed; of them, 15 were case–control studies, case series, or case reports, and two were randomized controlled trials. The presently available management strategies for ACNES include trigger point injections (diagnostic and therapeutic, ultrasound-guided blocks, chemical neurolysis, and surgical ­neurectomy, in combination with systemic medication, as well as some emerging techniques, such as radiofrequency ablation and neuromodulation. An increased awareness of the syndrome and the use of specific diagnostic criteria for its recognition are required to facilitate an early and successful management. This review compiles the proposed ­management strategies for ACNES. Keywords: anterior cutaneous nerve entrapment syndrome, intercostal, neuralgia, management

  1. Cutaneous pancreatic metastasis: a case report and review of literature.

    Science.gov (United States)

    Hafez, Hza

    2007-01-01

    Pancreatic cancer is one of the most lethal human cancers and continues to be a major unsolved health problem as we enter the 21st century. This is the case despite advances in imaging technology and surgical management. Indeed, 80-90% of pancreatic cancers are diagnosed either at the locally advanced stage or metastatic stage. Cutaneous metastases originating from pancreatic cancer are relatively rare. The most common site of cutaneous metastasis is the umbilicus, and it is known as the Sister Joseph's nodule. Very few patients have been reported with cutaneous lesions disclosing pancreatic carcinoma at sites other than the umbilical area. To our knowledge, there were no previous reports on cutaneous pancreatic metastasis in Egypt. This is a report of a patient with cutaneous pancreatic metastases at the neck, followed by a review of reported non-umbilical cutaneous metastases from pancreatic carcinoma in the literature.

  2. Le zapping, les ethnologues, et leurs Indiens

    Directory of Open Access Journals (Sweden)

    Frédérique Langue

    2005-06-01

    Full Text Available Comme toujours s'agissant des expositions mises en scène au Grand Palais, la présentation est parfaite, impeccable. La mise en valeur des objets venus aussi bien de musées brésiliens qu'européens, et les commentaires qui les accompagnent, orientent le visiteur dans un labyrinthe "exotique" de poteries et d'objets de plume, coupé de temps à autre de documentaires portant sur les rituels amérindiens, chants psalmodiques à l'appui. L'auditoire y semble comme vissé sur place, davantage d'ailleur...

  3. New Light Alloys (Les Nouveaux Alliages Legers)

    Science.gov (United States)

    1990-09-01

    abord~s lors de la conference on distingue: la physique des m~taux et les traitements, les caract~ristiques des materiaux existants et les perspectives...I’Ngide du Panel AGARD des Structures et Materiaux . iii List of Authors/Speakers Lecture Series Director: IGA P.Costa Directeur Scientifique des Mat...rairalement amorphes, pr~sentent l’avantage de pouvoir ktre synth~tisds A temp&ature ambiante soit A partir de suspensions colloidales d’oxydes ou d’hydroxydes

  4. Devastating posttraumatic primary cutaneous mucormycosis in a diabetic patient

    Directory of Open Access Journals (Sweden)

    Poongodi Lakshmi Santhana Kumarasamy

    2016-01-01

    Full Text Available Mucorales are saprophytic fungi causing mucormycosis, which is a life threatening infection manifested as rhinocerebral, pulmonary, gastrointestinal, cutaneous, and disseminated forms. The cutaneous form is further divided into primary and secondary forms. The major risk factors include uncontrolled diabetes mellitus with or without ketoacidosis, other forms of metabolic acidosis, and trauma. We report here a case of primary cutaneous mucormycosis caused by Rhizopus oryzae, in a diabetic after a road traffic accident.

  5. Periorbital mucinosis: a variant of cutaneous lupus erythematosus?

    Science.gov (United States)

    Morales-Burgos, Adisbeth; Sánchez, Jorge L; Gonzalez-Chávez, José; Vega, Janelle; Justiniano, Hildamari

    2010-04-01

    Lupus erythematosus has a wide spectrum of cutaneous manifestations, including periorbital mucinosis. We report 3 cases of periorbital mucinosis occurring in association with other cutaneous signs of lupus erythematosus. Based on a review of the literature, periorbital mucinosis is a rare and not widely recognized clinical manifestation of the disease. Although unusual, familiarity with periorbital mucinosis as a manifestation of lupus erythematosus broadens our understanding of these entities and expands the spectrum of cutaneous lupus erythematosus.

  6. Cutaneous metastases from head and neck squamous cell carcinoma.

    Science.gov (United States)

    Poovaneswaran, Sangeetha; Paleri, Vinidh; Charlton, Fraser; Dobrowsky, Werner; Kelly, Charles

    2012-08-01

    The presence of cutaneous metastases in squamous cell carcinomas of the head and neck (SCCHN) is rare and associated with a dismal prognosis. It is vital to distinguish these lesions from direct invasion of the skin by SCCHN or primary cutaneous malignancies as the prognosis is vastly different and so is the management. In this case report, we present four cases of cutaneous metastases and also briefly review the literature pertaining to this phenomenon.

  7. Radiotherapy for cutaneous cancers with xeroderma pigmentosum; Radiotherapie des cancers cutanes au cours du xeroderma pigmentosum

    Energy Technology Data Exchange (ETDEWEB)

    Ben Salah, H.; Bahri, M.; Turki, H.; Abdelmoula, M.; Frikha, M.; Daoud, J. [Service de radiotherapie, CHU Habib-Bourguiba, route Majida-Bouleila, 3029 Sfax (Tunisia)

    2011-08-15

    Purpose. - To analyze the therapeutic results of cutaneous cancers on xeroderma pigmentosum through a series of 15 patients treated by radiotherapy. Patients and methods. - Between 1993 and 2006, 15 patients with xeroderma pigmentosum and having cutaneous cancers were treated in the Radiotherapy Department of university hospital Habib-Bourguiba of Sfax in Tunisia. Seventy-three percent of the cases occurred in male patients and the mean age of appearance of the first tumour was 18.2 years. Tumour histology was squamous cell carcinoma in 74% of the cases. The total number of cutaneous tumours was 84. Ten patients had a surgical resection. Four patients did not respond to chemotherapy. The modality of irradiation was decided according to the size, thickness and localization of the tumour. The dose of radiotherapy was 60 Gy or equivalent with classic irradiation. Results. - The total number of lesions treated with radiotherapy was 64. Forty-three lesions were treated with contact-therapy, ten with brachytherapy and 11 with cobalt-therapy. The following acute complications were observed: cutaneous infection (53.3% of patients), radio-epithelitis (80% of patients) and necroses (33.3% of patients). Evaluation after treatment showed a clinical complete remission in 73% of the cases. Late effects were noted in seven cases: telangiectasia and cutaneous atrophy. A recurrence in the irradiated zone was observed in one case. A nodal metastasis was observed in two cases. Another patient presented lung metastases. After a median follow up of 37.2 months, four patients died, seven are alive with cutaneous cancer and four are alive with complete remission. Conclusion. - Radiotherapy is a possible and effective therapeutic alternative. Dose and methods are not defined for xeroderma pigmentosum. (authors)

  8. Gender disparity between cutaneous and non-cutaneous manifestations of Lyme borreliosis.

    Directory of Open Access Journals (Sweden)

    Franc Strle

    Full Text Available Cutaneous manifestations of Lyme borreliosis in Europe include erythema migrans (EM and acrodermatitis chronica atrophicans (ACA; the most common non-cutaneous manifestations are Lyme neuroborreliosis (LNB and Lyme arthritis. The purpose of this study was to evaluate the gender distribution of patients with these clinical manifestations of Lyme borreliosis. Data on gender were obtained from the clinical records of patients with Lyme borreliosis aged ≥15 years who had been evaluated at the University Medical Center Ljubljana, Ljubljana, Slovenia. Among 10,539 patients diagnosed with EM, 6,245 (59.3% were female and among 506 ACA patients 347 (68.6% were female. In contrast, among the 60 patients with Lyme arthritis only 15 (25% were female (p<0.0001 for the comparison of gender with EM or ACA and among the 130 patients with LNB only 51 (39.2% were females (p<0.0001for the comparison of gender with EM or ACA. Although the proportion that was female in the LNB group was greater than that of patients with Lyme arthritis, this difference did not reach statistical significance (p = 0.10. Although older individuals are more likely to be female in the general Slovenian population, the age of patients with cutaneous versus non-cutaneous manifestations was not the explanation for the observed differences in gender. In conclusion, patients with cutaneous manifestations of Lyme borreliosis were predominantly female, whereas those with non-cutaneous manifestations were predominantly male. This provocative finding is unexplained but may have direct relevance to the pathogenesis of Lyme borreliosis.

  9. Pemphigoïde gestationis et aplasie cutanée congénitale: à propos d'un cas

    Science.gov (United States)

    Hakimi, Ihssane; Benabdejlil, Youssef; Ourraï, Abdelhakim; Kouach, Jaouad; Moussaoui, Driss; Deyahni, Mohammed

    2014-01-01

    La pemphigoïde gestationis est une dermatose gravidique apparaissant en général entre la 28ème et la 32ème semaine d'aménorrhée. L’éruption cutanée est prurigineuse, bulleuse ou vésiculopapuleuse et de topographie péri-ombilicale. Outre la clinique, son diagnostic repose sur la biopsie cutanée avec analyse en immunofluorescence directe. Elle se caractérise par sa tendance à récidiver. Le traitement habituel nécessite des dermocorticoïdes. Les conséquences peuvent être maternelles (menace d'accouchement prématuré), fœtales (retard de croissance intra-utérin), et néo-natales (éruption cutanée). Nous rapportons un cas de pemphigoïde gestationis associé à une aplasie cutanée congénitale type 2. S'agit il d'une association fortuite? PMID:25667709

  10. Lésions bulleuses et purpuriques unilatérales: pathomimie cutanée

    Science.gov (United States)

    Zinoun, Mouna; Chiheb, Soumia; Marnissi, Farida; Kadiri, Nadia; Benchikhi, Hakima

    2015-01-01

    La pathomimie cutanée est une forme particulière de troubles factices relativement rare, et constitue l'un des problèmes les plus complexes pour le dermatologue. Nous rapportons un cas de pathomimie révélée par des lésions cutanées unilatérales, mimant une brûlure. Une jeune femme de 27 ans, était suivie depuis 4 ans pour une dépression. Elle a présenté 15j avant sa 1ère hospitalisation un placard inflammatoire du sein gauche compliqué de lésions bulleuses et d’érosions superficielles. La biopsie cutanée avait montré une dermite non spécifique. Une cicatrisation rapide sous traitement local a été notée. Elle a présenté 10 jours plus tard de nouvelles lésions similaires étagées au membre inférieur gauche, évoluant vers le décollement bulleux spontané. La biopsie cutanée avait montré un décollement bulleux jonctionnel et des foyers de nécrose ischémique. L'IFD était négative. Devant les données anamnestiques, cliniques, la négativité du bilan paraclinique, et la guérison des lésions sous pansements occlusifs seuls, le diagnostic de pathomimie a été évoqué et retenu. La patiente a été adressée en psychiatrie où une thérapie cognitivo-comportementale a été préconisée. Notre observation correspond à un tableau de pathomimie de présentation clinique particulière par sa localisation unilatérale et son caractère bulleux. Chez notre patiente qui est droitière, la localisation unilatérale gauche sur des zones accessibles, l'absence de lésions spécifiques à l'examen histologique, la cicatrisation rapide des lésions sous traitement local occlusif seul et leur récurrence malgré des soins adaptés étaient en faveur d'une pathologie factice. Néanmoins, la localisation au niveau des seins peut être très déroutante. Le caractère bulleux des lésions dans le cadre d'une pathomimie a été rarement rapporté. Dans notre cas, la pathomimie s'associe à des troubles anxieux et dépressifs très importants

  11. A CUTANEOUS HORN MIMICKING POLYDACTYLY: A CASE REPORT

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    Funda Tamer

    2015-04-01

    Full Text Available A cutaneous horn is a general name for cornified material protruding from skin. On the other hand, polydactyly is a common congenital anomaly of the hand and foot which is characterized by extra finger or toe. A cutaneous horn might mimick polydactyly by resembling an extra toe. Hereby, we present a 72-year-old white Caucasian male with an extra toe-like projection on his fourth toe. Initially, polydactyly was suspected, however a cutaneous horn was also considered. The lesion was surgically removed. The histopathological examination of the specimen revealed hyperkeratosis, and thus confirmed the  lesion to be a cutaneous horn. 

  12. ECTOPIC CUTANEOUS SCHISTOSOMIASIS: REPORT OF TWO CASES AND A REVIEW OF THE LITERATURE

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    José de Souza ANDRADE FILHO

    1998-07-01

    Full Text Available Two cases of ectopic cutaneous schistosomiasis are described. Both patients presented with abdominal papular skin lesions, which on biopsy were found to contain granulomas with Schistosoma mansoni eggs. Twenty-five other cases were retrieved from the literature. Most patients were female, mean age 24.9 year, with a predominance of the white race. The most common localization was anterior thorax and abdomen. Usually, the lesions were asymptomatic. In few cases, however, severe clinical syndromes due to the parasite coexisted, such as transverse myelitis or the acute-toxemic form of the disease. Intestinal infection was not frequently demonstrated in these patients. The importance of the recognition of these cutaneous lesions may rest on the opportunity to provide an etiological diagnosis in these difficult cases.Dois casos de esquistossomose cutânea ectópica são relatados. Ambos os pacientes apresentavam lesões papulares no abdômen que, ao exame histopatológico, mostraram presença de granulomas contendo ovos de Schistosoma mansoni. Vinte e cinco casos de esquistossomose cutânea ectópica foram encontrados descritos na literatura. A maioria dos pacientes era do sexo feminino, com idade média de 24,9 anos e predominância da raça branca. A localização mais comum foi o tórax anterior e abdômen. Freqüentemente, as lesões eram assintomáticas. Em alguns casos, no entanto, coexistiam alterações sistêmicas graves, relacionadas ao parasito, como mielite transversa e a forma aguda toxêmica da doença. Na maior parte dos casos, a infecção intestinal não pôde ser demonstrada. O reconhecimento destas lesões cutâneas pode ser importante por proporcionar oportunidade para um diagnostico etiológico nestes casos.

  13. Quand le crédit à la consommation classe les gens et les choses

    DEFF Research Database (Denmark)

    Ossandón, José

    2012-01-01

    Le développement du crédit à la consommation est l’une des principales manifestations de la financiarisation de l’économie. Les éléments institutionnels et techniques qui lui ont donné forme tels que les dispositifs d’attribution de score aux consommateurs, de détermination des taux ou encore les...... structuration et que ces travaux empiriques contribuent de façon originale à la sociologie....

  14. Les produits de la mer se diversifient

    OpenAIRE

    Penez, Jacqueline

    1993-01-01

    L'idée qui prévaut dans l'opinion du public est la surexploitation de la mer. Or, seule une très faible partie de la biomasse marine est prélevée via les pêches et cultures marines. Traditionnellement appréciés pour leurs qualités nutritionnelles, les poissons représentent de surcroît une importante source de molécules dont les activités biologiques intéressent au plus haut point les industries pharmaceutiques et cosmétiques La part de ces molécules marines, comparée aux matières premières d'...

  15. A Les Houches Interface for BSM Generators

    Energy Technology Data Exchange (ETDEWEB)

    Alwall, J.; /SLAC; Boos, E.; Dudko, L.; /SINP, Moscow; Gigg, M.; /Durham U., IPPP; Herquet, M.; /Louvain U., CP3; Pukhov, A.; /Moscow State U.; Richardson, P.; /Durham U., IPPP /CERN; Sherstnev, A.; /Cambridge U. /SINP, Moscow; Skands, P.; /CERN /Fermilab

    2007-12-01

    We propose to combine and slightly extend two existing 'Les Houches Accords' to provide a simple generic interface between beyond-the-standard-model parton-level and event-level generators. All relevant information--particle content, quantum numbers of new states, masses, cross sections, parton-level events, etc.--is collected in one single file, which adheres to the Les Houches Event File (LHEF) standard.

  16. A Les Houches Interface for BSM Generators

    Energy Technology Data Exchange (ETDEWEB)

    Alwall, J.; /SLAC; Boos, E.; Dudko, L.; /SINP, Moscow; Gigg, M.; /Durham U., IPPP; Herquet, M.; /Louvain U., CP3; Pukhov, A.; /Moscow State U.; Richardson, P.; /Durham U., IPPP /CERN; Sherstnev, A.; /Cambridge U. /SINP, Moscow; Skands, P.; /CERN /Fermilab

    2008-01-23

    We propose to combine and slightly extend two existing 'Les Houches Accords' to provide a simple generic interface between beyond-the-standard-model parton-level and event-level generators. All relevant information--particle content, quantum numbers of new states, masses, cross sections, parton-level events, etc.--is collected in one single file, which adheres to the Les Houches Event File (LHEF) standard.

  17. Les atomes existent-ils vraiment ?

    CERN Document Server

    Diu, Bernard

    1997-01-01

    Peu de notions scientifiques ont autant suscité l'imagination spéculative que l'entropie thermodynamique. Tous les systèmes organisés - les sociétés, les êtres vivants - seraient promis à la décadence, à la mort, forcément. Ce livre expose en toute clarté le développement historique et conceptuel de la thermodynamique. Née du désir de comprendre et de maîtriser le fonctionnement des machines à vapeur - emblème de nos sociétés industrielles -, elle est devenue la science des corps, de tous les corps à notre échelle. Mais elle se passait sans états d'âme de l'hypothèse atomique. Elle a donc été battue en brèche par la mécanique statistique qui faisait droit aux impératifs dictés par la structure atomique des corps. Après une lutte épique, et même sanglante, thermodynamique et mécanique statistique se sont réconciliées sur les fondements de la seconde mais avec les techniques de la première. Ce livre se lit comme un roman de physique contemporaine.

  18. LES versus DNS: A comparative study

    Science.gov (United States)

    Shtilman, L.; Chasnov, J. R.

    1992-01-01

    We have performed Direct Numerical Simulations (DNS) and Large Eddy Simulations (LES) of forced isotropic turbulence at moderate Reynolds numbers. The subgrid scale model used in the LES is based on an eddy viscosity which adjusts instantaneously the energy spectrum of the LES to that of the DNS. The statistics of the large scales of the DNS (filtered DNS field or fDNS) are compared to that of the LES. We present results for the transfer spectra, the skewness and flatness factors of the velocity components, the PDF's of the angle between the vorticity and the eigenvectors of the rate of strain, and that between the vorticity and the vorticity stretching tensor. The above LES statistics are found to be in good agreement with those measured in the fDNS field. We further observe that in all the numerical measurements, the trend was for the LES field to be more gaussian than the fDNS field. Future research on this point is planned.

  19. Platelet gel for healing cutaneous chronic wounds.

    Science.gov (United States)

    Crovetti, Giovanni; Martinelli, Giovanna; Issi, Marwan; Barone, Marilde; Guizzardi, Marco; Campanati, Barbara; Moroni, Marco; Carabelli, Angelo

    2004-04-01

    Wound healing is a specific host immune response for restoration of tissue integrity. Experimental studies demonstrated an alteration of growth factors activity due to their reduced synthesis, increased degradation and inactivation. In wound healing platelets play an essential role since they are rich of alpha-granules growth factors (platelet derived growth factor--PDGF; transforming growth factor-beta--TGF-beta; vascular endothelial growth factor--VEGF). Topical use of platelet gel (PG), hemocomponent obtained from mix of activated platelets and cryoprecipitate, gives the exogenous and in situ adding of growth factors (GF). The hemocomponents are of autologous or homologous origin. We performed a technique based on: multicomponent apheretic procedure to obtain plasma rich platelet and cryoprecipitate; manual processing in an open system, in sterile environment, for gel activation. Every step of the gel synthesis was checked by a quality control programme. The therapeutic protocol consists of the once-weekly application of PG. Progressive reduction of the wound size, granulation tissue forming, wound bed detersion, regression and absence of infective processes were considered for evaluating clinical response to hemotherapy. 24 patients were enrolled. They had single or multiple cutaneous ulcers with different ethiopathogenesis. Only 3 patients could perform autologous withdrawal; in the others homologous hemocomponent were used, always considering suitability and traceability criteria for transfusional use of blood. Complete response was observed in 9 patients, 2 were subjected to cutaneous graft, 4 stopped treatment, 9 had partial response and are still receiving the treatment. In each case granulation tissue forming increased following to the first PG applications, while complete re-epithelization was obtained later. Pain was reduced in every treated patient. Topical haemotherapy with PG may be considered as an adjuvant treatment of a multidisciplinary process

  20. Cutaneous metastasis from lung cancer. Case report.

    Science.gov (United States)

    Fratus, Giorgio; Tagliabue, Fabio; Mariani, Pierpaolo; Bottazzi, Enrico Coppola; Spinelli, Luisella; Novellino, Lorenzo

    2014-07-21

    Lung cancer is the most common neoplasm diagnosed worldwide. Metastatic presentation of the disease is frequent. Apart from the usual sites of metastatic disease (bone, adrenals, liver, brain), a particular site for metastases is represented by skin. The case we report is about a 66 year-old man with cutaneous metastasis from lung cancer. A 66 year-old man, with a previous history of abdominal aortic aneurism, chronic obstructive pulmonary disease, cardiopathy, diabetes mellitus, was admitted to our institution for left lower lobe lung cancer. After accurate preoperative staging, patient underwent a thoracotomic left lower lobectomy. Histological examination revealed a squamocellular carcinoma: G2-3, pT2bN0. Patient underwent oncological evaluation for the scheduled follow up. After 6 months patient went back to our observation for the appearance of a skin nodule, firm, dischromic, painful and ulcerated, localized in right iliac fossa. Biopsies demonstrated the nodule to be squamocellular carcinoma. Patient underwent a CT scan of the abdomen and thorax, which revealed the absence of infiltration of the deep fascial and muscular planes by the neoplasm. Patient underwent surgical removal of the lesion. Final histological examination confirmed the lesion to be metastasis of squamocellular lung cancer. Metastases from lung cancer occur in about 2,5-7,5% of cases. Median survival for these patients is 2,9 months. The most common type of neoplasm, according to Japanese Authors, is adenocarcinoma followed by squamocellular carcinoma. Some studies demonstrated the adequacy of surgery followed by chemotherapy, in case of single lesion. In case of multiple cutaneous metastases, many Authors suggest only chemotherapy, although the ideal scheme hasn't been discovered yet. Cutaneous metastases from lung cancer are rare; however the appearance of skin lesions, in patients with a positive oncological history, requires much attention. Accurate evaluation of the patient is

  1. Topical Application of Fingolimod Perturbs Cutaneous Inflammation.

    Science.gov (United States)

    Sun, Wai Y; Dimasi, David P; Pitman, Melissa R; Zhuang, YiZhong; Heddle, Robert; Pitson, Stuart M; Grimbaldeston, Michele A; Bonder, Claudine S

    2016-05-01

    The prevalence of allergies, including rhinitis, eczema, and anaphylaxis, is rising dramatically worldwide. This increase is especially problematic in children who bear the greatest burden of this rising trend. Increasing evidence identifies neutrophils as primary perpetrators of the more severe and difficult to manage forms of inflammation. A newly recognized mechanism by which neutrophils are recruited during the early phase of histamine-induced inflammation involves the sphingosine kinase (SK)/sphingosine-1-phosphate axis. This study examines whether topical application of fingolimod, an established SK/sphingosine-1-phosphate antagonist already in clinical use to treat multiple sclerosis, may be repurposed to treat cutaneous inflammation. Using two mouse models of ear skin inflammation (histamine- and IgE-mediated passive cutaneous anaphylaxis) we topically applied fingolimod prophylactically, as well as after establishment of the inflammatory response, and examined ear swelling, SK activity, vascular permeability, leukocyte recruitment, and production of proinflammatory mediators. The present study reveals that when applied topically, fingolimod attenuates both immediate and late-phase responses to histamine with reduced extravasation of fluid, SK-1 activity, proinflammatory cytokine and chemokine production, and neutrophil influx and prevents ear swelling. Intravital microscopy demonstrates that histamine-induced neutrophil rolling and adhesion to the postcapillary venules in the mouse ears is significantly attenuated even after 24 h. More importantly, these effects are achievable even once inflammation is established. Translation into humans was also accomplished with epicutaneous application of fingolimod resolving histamine-induced and allergen-induced inflammatory reactions in forearm skin. Overall, this study demonstrates, to our knowledge for the first time, that fingolimod may be repurposed to treat cutaneous inflammation.

  2. Histological variants of cutaneous Kaposi sarcoma

    Directory of Open Access Journals (Sweden)

    Pantanowitz Liron

    2008-07-01

    Full Text Available Abstract This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage; morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

  3. Cutaneous drug hypersensitivity : Immunological and genetic perspective

    Directory of Open Access Journals (Sweden)

    Kisalay Ghosh

    2011-01-01

    Full Text Available Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of "hapten concept" in immune sensitization has recently been contested by the "pharmacological interaction" hypothesis. After completion of the "human genome project" and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity.

  4. Massive zosteriform cutaneous metastasis from rectal carcinoma.

    Science.gov (United States)

    Damin, D C; Lazzaron, A R; Tarta, C; Cartel, A; Rosito, M A

    2003-07-01

    A 44-year-old man presented with a large and rapidly growing skin lesion approximately six months after resection of a rectal carcinoma. The lesion measured 40 cm in size, extended from the suprapubic area to the proximal half of the left groin, and showed a particular zosteriform aspect. Biopsy confirmed a metastatic skin adenocarcinoma. Cutaneous metastases from rectal cancer are very uncommon. Their gross appearance is not distinctive, although the skin tumors are usually solid, small (less than 5 cm) and painless nodules or papules. Early biopsies for suspicious skin lesions are needed in patients with a history of colorectal cancer.

  5. Cutaneous Manifestations in Renal Transplant Recipients

    Directory of Open Access Journals (Sweden)

    Fatma Elif Demirgüneş

    2008-05-01

    Full Text Available Background and Design: This study is designed to determine the prevalence and the clinical spectrum of skin diseases in renal transplant recipients (RTRs.Material and Method: In this study RTRs who were referred to our department between 2005 and 2007 for dermatologic examination were evaluated. Dermatologic investigation included direct clinical observation and culture or histolopathological investigation when indicated. Patients were divided into three groups: group A, post-transplantation periods £1 year; group B, post-transplantation periods of 1-5 years; and group C, post-transplantation periods >5 years. Results: In this study 88 (M=50, F=38 RTRs were evaluated. The mean age was 37 ± 12 years and the median interval since transplantation was 38.5 months (range=1 month-27 years. Over a 2-year period 298 cutaneous manifestations were identified. Ninety-five immunosuppressive (IS drug-related manifestations were observed in 58 (%65.9 patients and the most common one was acneiform eruption (n=23. Forty (45.5% patients developed cutaneous viral infections, consisting of verruca vulgaris (n=29, herpes zoster (n=9, herpes simplex (n=5, molluscum (n=2 and varicella (n=1 infections. Superficial fungal infections were observed in 35(39.2% patients, most common lesions were dermatophytosis (n = 23 and pityriasis versicolor (n=17. Bacterial infections were observed in 14 (%16 patients, folliculitis was present in 12 of them. Premalignant and malignant lesions were identified in 12 (%13.6 patients, consisting of actinic keratoses (n=9, basal cell carcinoma (n=2, squamous cell carcinoma (n=1 and Kaposi's sarcoma (n=1. There were more premalignant and malignant lesions in patients receiving azathioprine (p=0.002. Cutaneous viral infections were more common in group C (p=0.023 and IS drug-related manifestations were more common in group A (p=0.003. Conclusion: Most common cutaneous manifestation among RTRs was IS drug-related and seen in early post

  6. Primary cutaneous plasmacytosis: Masquerading as hidradenitis suppurativa

    Directory of Open Access Journals (Sweden)

    Tarang Goyal

    2016-01-01

    Full Text Available Isolated cutaneous plasmacytosis (CP is a rare entity with few cases reported in world literature. CP masquerading as hidradenitis suppurativa like presentation is a unique case with some features differentiating it clinically from it which were further confirmed by histopathology and immunostaining. Our case showed hyperplasia of mature plasma cells and polyclonal hypergammaglobulinemia, immunostaining for CD138 positivity and kappa: lambda ratio more than 3:1. Extensive clinical and laboratory investigations failed to reveal any underlying pathology, presence of any underlying disease accompanying the hypergammaglobulinemia and/or plasma cell proliferation.

  7. Dermoscopic patterns of cutaneous melanoma metastases.

    Science.gov (United States)

    Rubegni, Pietro; Lamberti, Arianna; Mandato, Filomena; Perotti, Roberto; Fimiani, Michele

    2014-04-01

    In 2-8% of patients with melanoma, the first clinical manifestation of the disease may be skin metastasis. In these cases, differential diagnosis with the primary melanoma, benign melanocytic lesions, and other malignant and benign skin growths is particularly challenging. For this reason, the dermatologist's approach to cutaneous metastases of malignant melanoma calls for knowledge of the great morphological variety of these lesions. Dermoscopic characteristics associated with CMMMs have not yet been codified. The aim of the present review is to provide additional information about dermoscopic aspects of these skin lesions.

  8. Primary cutaneous mucormycosis in an immunocompetent patient.

    Science.gov (United States)

    Paduraru, Mihai; Moreno-Sanz, Carlos; Olalla Gallardo, Jose Maria

    2016-08-16

    Mucormycosis is most common in immunocompromised patients, but it can also occur in healthy hosts, most frequently as primary cutaneous mucormycosis (PCM) and predominantly as a result of skin trauma. We present an uncommon case of PCM in a healthy, young man with no previous history of local trauma. Despite rapid progression of the infection, the patient was successfully treated through surgical intervention and by administering liposomal amphotericin B and posaconazole. He made a full recovery without the need for skin grafting. 2016 BMJ Publishing Group Ltd.

  9. Cutaneous and systemic complications associated with tattooing.

    Science.gov (United States)

    Kluger, Nicolas

    2016-06-01

    Tattooing can result in a wide variety of complications, whose prevalence and incidence remain still unclear. Hypersensitivity reactions (or allergies) to tattoo pigments are currently the most common complication on a tattoo, however they are not predictable. Infections are nowadays directly related to the lack of asepsis and hygiene during the tattooing procedure or during the healing phase. Patients with a known cutaneous disease should be warned of a potential risk of localization of their disease to the tattoo. A skin eruption restricted to a tattoo may reveal sarcoidosis. Patients with chronic conditions and/or impaired immunity should discuss with their physician about the possibility and when to have a tattoo.

  10. Molecular pathogenesis of cutaneous melanocytic neoplasms.

    Science.gov (United States)

    Ibrahim, Nageatte; Haluska, Frank G

    2009-01-01

    Melanoma is the deadliest form of skin cancer without an effective treatment. An understanding of the genetic basis of melanoma has recently shed light on some of the mechanisms of melanomagenesis. This review explores the major genes involved in familial and sporadic cutaneous melanoma with an emphasis on CDKN2A, CDK4, MC1R, and MAPK pathway targets (e.g., RAS and BRAF), apoptosis regulators (e.g., BCL-2, AKT, and APAF-1), and the tumor-suppressor genes TP53 and PTEN. New directions for therapeutics based on our current knowledge of the genes implicated in melanoma are also discussed.

  11. Les Elements Legers: Diffusion dans les Enveloppes Stellaires et Implications Cosmologiques

    Science.gov (United States)

    Richer, Jacques

    1992-01-01

    Les observations des abondances des elements legers (Z premieres minutes de l'expansion de l'Univers. Nous tenons compte de la difference possible entre l'abondance primordiale de Li et les abondances observees dans les plus vieilles etoiles. Cette difference (un facteur 2, environ) est estimee en construisant des modeles evolutifs d'etoiles peu massives de Population II, incluant la sedimentation gravitationnelle du lithium et de l'helium. Ces modeles montrent egalement que les ages des vieux amas stellaires sont grandement surestimes lorsqu'ils sont determines a partir de modeles stellaires n'incluant pas l'effet de la diffusion de He. Nous calculons ensuite comment evoluent les abondances de Li et Be dans des etoiles plus massives et plus jeunes, de la pre-sequence principale ou de la ZAMS, jusqu'a l'epuisement de leur hydrogene central. Les modeles incluent la sedimentation simultanee de l'helium a travers l'enveloppe. Une approche hierarchique (evolution du coeur--evolution de l'enveloppe --tri des elements traces) est utilisee pour simuler efficacement le grand nombre d'etoiles necessaire pour la construction d'isochrones. Une attention particuliere est portee aux consequences de la sedimentation de He sur l'etendue des zones convectives, et sur la diffusion de Li et Be. Les forces radiatives agissant sur ces deux elements sont calculees en detail a partir des donnees atomiques. Les etoiles simulees correspondent approximativement aux types spectraux A, F, et AmFm. Les abondances de Li et Be observees dans les etoiles jeunes de ces types sont comparees a nos predictions dans le but d'identifier les conditions ou la diffusion peut etre le processus principal. ou un processus important controlant les abondances superficielles observees. La position et la profondeur du "trou du lithium" observe parmi les etoiles F des Hyades et d'autres amas jeunes, sont reproduites sans l'aide de parametres ajustables; cet accord n'est obtenu que si les recentes opacites OPAL

  12. Les paradoxes du littoral Swahili

    Directory of Open Access Journals (Sweden)

    François Bart

    2008-10-01

    Full Text Available Le contact entre l'océan Indien occidental et le continent africain a forgé l'identité et l'originalité du littoral swahili. Cette interface, longue d'environ 2 000 kilomètres, du sud de la Somalie au nord du Mozambique, constitue un monde original où, au gré de traditions anciennes de circulation maritime et continentale se sont diffusées et mêlées des influences culturelles venues du continent africain, de la péninsule arabique et de la péninsule indienne. Le développement du continent, du littoral et des archipels s'inscrit dans une double logique de fragmentation et d'ouverture au monde. Dans cette vaste aire géographique, le rôle de relais des îles et des axes de pénétration continentale à partir des ports est essentiel.The identity and the original features of the Swahili seashore mainly proceed from the contact of African mainland and western indian Ocean. This coastal interface, stretching over 2 000 kilometres from southern Somalia to northern Mozambique, is characterized by ancient traditions of trade movements through maritime areas and mainland as well, which spread and mixed different cultural influences originating from Africa and both Arabic and Indian peninsulas. The development of this area is linked to both fragmentation and opening dynamics. In such a wide area, the relaying function of islands and continental corridors from main harbours is very important.

  13. Cutaneous Force Feedback as a Sensory Subtraction Technique in Haptics.

    Science.gov (United States)

    Prattichizzo, D; Pacchierotti, C; Rosati, G

    2012-01-01

    A novel sensory substitution technique is presented. Kinesthetic and cutaneous force feedback are substituted by cutaneous feedback (CF) only, provided by two wearable devices able to apply forces to the index finger and the thumb, while holding a handle during a teleoperation task. The force pattern, fed back to the user while using the cutaneous devices, is similar, in terms of intensity and area of application, to the cutaneous force pattern applied to the finger pad while interacting with a haptic device providing both cutaneous and kinesthetic force feedback. The pattern generated using the cutaneous devices can be thought as a subtraction between the complete haptic feedback (HF) and the kinesthetic part of it. For this reason, we refer to this approach as sensory subtraction instead of sensory substitution. A needle insertion scenario is considered to validate the approach. The haptic device is connected to a virtual environment simulating a needle insertion task. Experiments show that the perception of inserting a needle using the cutaneous-only force feedback is nearly indistinguishable from the one felt by the user while using both cutaneous and kinesthetic feedback. As most of the sensory substitution approaches, the proposed sensory subtraction technique also has the advantage of not suffering from stability issues of teleoperation systems due, for instance, to communication delays. Moreover, experiments show that the sensory subtraction technique outperforms sensory substitution with more conventional visual feedback (VF).

  14. Cutaneous metastasis from a myoepithelial carcinoma of submandibular salivary gland.

    Science.gov (United States)

    Chougule, Abhijit; Barwad, Adarsh; Bal, Amanjit; Dey, Pranab

    2015-01-01

    Myoepithelial carcinoma is a rare malignant tumor of salivary gland with locally aggressive nature and potential for distant metastasis. It is composed of tumor cells with myoepithelial differentiation showing varied cytomorphology. Lungs and kidneys are the commonest sites for distant metastasis. Cutaneous metastasis of myoepithelial carcinoma is very rare. In this report, we described cutaneous metastasis of myoepithelial carcinoma arising from submandibular gland.

  15. Organotypic in vitro models of human cutaneous squamous cell carcinoma

    NARCIS (Netherlands)

    Commandeur, Suzan

    2013-01-01

    Skin cancer is the most common type of cancer in fair-skinned populations. Cutaneous squamous cell carcinoma (SCC) comprises about 15% of all skin cancer diagnoses. Treatment associated with the high and rising prevalence of cutaneous SCC puts an increasingly high financial burden on society,

  16. Organotypic in vitro models of human cutaneous squamous cell carcinoma

    NARCIS (Netherlands)

    Commandeur, Suzan

    2013-01-01

    Skin cancer is the most common type of cancer in fair-skinned populations. Cutaneous squamous cell carcinoma (SCC) comprises about 15% of all skin cancer diagnoses. Treatment associated with the high and rising prevalence of cutaneous SCC puts an increasingly high financial burden on society, markin

  17. Mélanome cutané épais: facteurs de mortalité et de survenue de métastases

    Science.gov (United States)

    Tarwate, Mariam; Benchikhi, Hakima; Adarmouch, Latifa; Benider, Abdelatif; Amine, Mohamed; Zamiati, Soumya; Boukind, El Hassan

    2014-01-01

    Au Maroc peu d’études ont été menées concernant les facteurs pronostiques du mélanome. L'objectif de cette étude était d'identifier les facteurs de survenue de métastases viscérales à distance à 1an et de mortalité à 2ans chez des patients atteints de mélanome cutané épais. Ont été colligés rétrospectivement tous les cas de mélanomes suivis au service de dermatologie et d'oncologie du CHU de Casablanca de 2006 à 2010. On été inclus les patients qui présentaient un mélanome à localisation cutanée et/ou muqueuse buccogénitale, confirmés histologiquement ayant un Breslow>2mm. Ont été exclus les patients présentant des métastases viscérales à distance au moment du diagnostic. Les données socio-démographiques, cliniques et thérapeutiques ont été recueillies au niveau des dossiers; celles relatives à l’évolution ont été complétées par contact téléphonique. L'analyse statistique était de type uni et bivarié. Soixante patients ont été inclus:41hommes et19femmes (sexe ratio de 2,15). La moyenne d’âge était de 60 ans (17-96). L'indice de Breslow était en moyenne de10mm+/-7et78%des patients(32) avaient un Breslow>4mm. Vingt trois patients (38,3%) avaient des adénopathies régionales. Quatorze patients ont présenté des métastases à distance après 1an (23,3%) et13patients étaient décédés après 2ans d’évolution (21,7%). Les facteurs associés à la survenue de métastases à distance étaient l'indice de Breslow. Des métastases à 1an ont été retrouvées chez 61,5%des patients avec un Breslow >10mm contre18,8% avec un Breslow PMID:25368733

  18. Cutaneous lichen planus: A systematic review of treatments.

    Science.gov (United States)

    Fazel, Nasim

    2015-06-01

    Various treatment modalities are available for cutaneous lichen planus. Pubmed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, and Health Technology Assessment Database were searched for all the systematic reviews and randomized controlled trials related to cutaneous lichen planus. Two systematic reviews and nine relevant randomized controlled trials were identified. Acitretin, griseofulvin, hydroxychloroquine and narrow band ultraviolet B are demonstrated to be effective in the treatment of cutaneous lichen planus. Sulfasalazine is effective, but has an unfavorable safety profile. KH1060, a vitamin D analogue, is not beneficial in the management of cutaneous lichen planus. Evidence from large scale randomized trials demonstrating the safety and efficacy for many other treatment modalities used to treat cutaneous lichen planus is simply not available.

  19. The Role of Neuromediators and Innervation in Cutaneous Wound Healing.

    Science.gov (United States)

    Ashrafi, Mohammed; Baguneid, Mohamed; Bayat, Ardeshir

    2016-06-15

    The skin is densely innervated with an intricate network of cutaneous nerves, neuromediators and specific receptors which influence a variety of physiological and disease processes. There is emerging evidence that cutaneous innervation may play an important role in mediating wound healing. This review aims to comprehensively examine the evidence that signifies the role of innervation during the overlapping stages of cutaneous wound healing. Numerous neuropeptides that are secreted by the sensory and autonomic nerve fibres play an essential part during the distinct phases of wound healing. Delayed wound healing in diabetes and fetal cutaneous regeneration following wounding further highlights the pivotal role skin innervation and its associated neuromediators play in wound healing. Understanding the mechanisms via which cutaneous innervation modulates wound healing in both the adult and fetus will provide opportunities to develop therapeutic devices which could manipulate skin innervation to aid wound healing.

  20. Radiologic misunderstanding of cutaneous angiomyolipoma in the alar base.

    Science.gov (United States)

    Han, Hyun Ho; Choi, Jong Yun; Seo, Bommie F; Mun, Suk Ho; Rhie, Jong Won; Ahn, Sang Tae; Oh, Deuk Young

    2014-07-01

    In this article, we will examine a case of cutaneous angiomyolipoma in the right nasal alar base area of a 36-year-old man. Generally, angiomyolipoma occurs in the kidney and, histologically, has features that are similar to cutaneous angiomyolipoma: smooth muscle cells, mature adipose cells, and a convoluted thick-walled blood vessel. Clinically, renal angiomyolipoma is related to tuberous sclerosis, but cutaneous angiomyolipomas occur very rarely, with a total of only 23 cases documented in the literature, with 39% (9/23) of those cases occurring in the ear or surrounding areas. In particular, the abundance of blood vessels inside a cutaneous angiomyolipoma produces good enhancement on computed tomographic image, making it easy for the tumor to be mistaken for a vascular tumor. In this particular case, we will report about a previously unheard case of cutaneous angiomyolipoma occurring in the nasal alar base that was mistaken for a vascular tumor.

  1. Migrations et modernité dans les îles Kerkennah

    OpenAIRE

    Ben Hamida, Abdesslem

    2006-01-01

    Les îles Kerkennah, au large de la ville de Sfax, à l’écart des circuits modernes semblent n’être qu’un conservatoire des traditions. Ces îles sont concernées par un important mouvement migratoire dû à un développement de la population et à une économie agricole et de pêche en stagnation. Y a-t-il un lien entre migration et modernité ? La colonisation a eu peu d’influence sur les îles Kerkennah, quelques apports sont à signaler au plan scolaire et sanitaire mais rien d’assez important pour le...

  2. Gradients socioéconomiques du risque cardiovasculaire chez les enfants et les adolescents canadiens

    Directory of Open Access Journals (Sweden)

    Y. Shi

    2016-01-01

    Full Text Available Introduction : Les maladies cardiovasculaires (MCV et leurs facteurs de risque présentent des gradients socioéconomiques clairs chez les adultes canadiens, mais présentent des ambiguïtés chez les enfants. L'objectif de cette étude est de vérifier l'existence ou non de gradients socioéconomiques dans les marqueurs physiologiques du risque de MCV chez les enfants et les adolescents canadiens. Méthodologie : À partir des données transversales combinées de l'Enquête canadienne sur les mesures de la santé 2007-2011, nous avons étudié, chez 2 149 enfants (6 à 11 ans et 2 073 adolescents (12 à 17 ans et selon le sexe, les marqueurs de risque cardiovasculaire suivants : excès de poids (y compris l'obésité, score de capacité aérobique (SCA, pression artérielle (PA, lipides sanguins (totaux, cholestérol LDL et HDL, triglycérides, métabolisme du glucose et protéine C réactive (CRP. Des analyses de régression logistique et de régression linéaire multidimensionnelles ont permis de dégager les tendances relatives au risque cardiovasculaire en fonction de la suffisance du revenu du ménage et du niveau de scolarité des parents, après ajustement en fonction de l'âge et de l'origine ethnique, et après stratification par groupe d'âge et par sexe. Résultats : La prévalence de l'obésité était sensiblement plus élevée chez les jeunes garçons que chez les jeunes filles (prévalence de 18,5 %, intervalle de confiance [IC] à 95 % : 15,6 à 21,5 contre 7,7 %, IC à 95 % : 5,2 à 10,3. Toutefois, des gradients socioéconomiques négatifs ont été observés en ce qui concerne le risque d'adiposité chez les jeunes filles et les adolescentes, et non chez les garçons. Parmi les enfants et les adolescents, les garçons étaient en meilleure condition physique que les filles (SCA moyen de 541, IC à 95 % : 534 à 546 contre 501, IC à 95 % : 498 à 505 chez les enfants; 522, IC à 95 % : 514 à 529 contre 460, IC à 95 % : 454

  3. Radiotherapy of cutaneous lymphoma other than mycosis fungoides. Radiotherapie des lymphomes cutanes autres que le mycosis fongoide

    Energy Technology Data Exchange (ETDEWEB)

    Ma, L.; Calitchi, E.; Levy, E.; Mazeron, J.J.; Le Bourgeois, J.P. (Hopital Henri-Mondor, 94 - Creteil (France))

    1994-01-01

    For cutaneous lymphoma (other than mycosis fungoides) in the early states, radiotherapy, whole-body electron irradiation included, may induced total remissions. As a palliative (state 4), a local irradiation allows a transitory control of cutaneous lesions. (A.B.). 4 refs., 1 tab.

  4. Immuncheckpointantistoffer øger overlevelsen for patienter med metastatisk melanom

    DEFF Research Database (Denmark)

    Fløe, Louise Elkjær; Svane, Inge Marie; Bastholt, Lars;

    2016-01-01

    The incidence of melanoma is rising and until recently, metastatic melanoma had a poor survival prognosis. Manipulation of two newly discovered immune pathways have shown impressive results. The first is treatment with anti-cytotoxic T-lymphocyte-antigen (CTLA)-4 antibody which blocks the inhibit...... the inhibitory receptor CTLA-4. The other is anti-programmed cell death (PD)-1 antibody which blocks the inhibitory receptor PD-1 on T-cells. Thereby, the T-cells are kept activated and able to attack cancer cells....

  5. PET-skanning ved malignt melanom og positiv sentinel node

    DEFF Research Database (Denmark)

    Horn, Janne; Sjøstrand, Helle; Lock-Andersen, Jørgen;

    2010-01-01

    To illuminate the value of using positron emission tomography (PET) scan as a clinical routine screening procedure for detecting subclinical metastases in melanoma patients with positive sentinel node biopsy, we carried out a retrospective study which included a total of 80 patients.......To illuminate the value of using positron emission tomography (PET) scan as a clinical routine screening procedure for detecting subclinical metastases in melanoma patients with positive sentinel node biopsy, we carried out a retrospective study which included a total of 80 patients....

  6. Prise en charge de l’infection gonococcique chez les adultes et les jeunes

    Science.gov (United States)

    Pogany, Lisa; Romanowski, Barbara; Robinson, Joan; Gale-Rowe, Margaret; Latham-Carmanico, Cathy; Weir, Christine; Wong, Tom

    2015-01-01

    Résumé Objectif Présenter des recommandations sur la prise en charge de l’infection gonococcique chez les adultes et les jeunes. Qualité des données Les recommandations thérapeutiques des lignes directrices canadiennes sur les infections transmissibles sexuellement reposent sur une recherche documentaire de même que sur des catégories de recommandations et des niveaux de qualité de données déterminés par au moins 2 évaluateurs. Les recommandations ont été revues par des pairs et sont en instance d’approbation par le groupe de travail d’experts. Message principal Les nouvelles recommandations portant sur la prise en charge de l’infection gonococcique chez les adultes et les jeunes préconisent les cultures à titre d’outil diagnostique lorsqu’elles sont pratiques, le traitement par antibiothérapie combinée (ceftriaxone associée à l’azithromycine) et le signalement sans délai de tous les cas dont le traitement a échoué aux autorités de santé publique. Conclusion Si elles sont suivies, ces nouvelles recommandations pourraient réduire l’échec thérapeutique, contribuer à une surveillance plus étroite des tendances à la résistance de Neisseria gonorrhoeae aux antibiotiques et contribuer à prévenir la transmission de gonorrhée résistante à plusieurs médicaments.

  7. Cutaneous calciphylaxis: a retrospective histopathologic evaluation.

    Science.gov (United States)

    Mochel, Mark C; Arakaki, Ryan Y; Wang, Guilin; Kroshinsky, Daniela; Hoang, Mai P

    2013-07-01

    Calciphylaxis is a rare and life-threatening disease characterized by cutaneous necrosis and vascular calcification. Often, skin biopsy specimens are not diagnostic because of the limited depth of the specimen, biopsy site, and clinical stage. To better understand the utility of various histologic features in rendering the diagnosis of calciphylaxis and to compare von Kossa versus Alizarin red stains in the detection of calcium deposits, we retrospectively analyzed the histologic features and histochemical stain findings of 56 skin biopsies from 27 consecutive patients seen at Massachusetts General Hospital from October 2002 to April 2012, with confirmed diagnosis of calciphylaxis and compared with that of 19 skin biopsies from 17 patients with other disease processes. All forms of vascular calcification and vascular thrombosis were significantly associated with cutaneous calciphylaxis. Perieccrine calcium deposition, highly specific to calciphylaxis, was the only form of calcium deposition noted in 4 (7%) skin biopsies from patients with calciphylaxis. Although the staining appears to be comparable, the deposits seen on Alizarin red appeared larger and were birefringent. Although subtle, perieccrine calcification may aid in the diagnosis of calciphylaxis in settings where typical vascular and extravascular calcification are not identified. Performing both von Kossa and Alizarin red stains might increase the detection of calcium deposit.

  8. Reconstructive dosimetry for cutaneous radiation syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Lima, C.M.A.; Lima, A.R.; Degenhardt, Ä.L.; Da Silva, F.C.A., E-mail: dasilva@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Valverde, N.J. [Fundacao Eletronuclear de Assistencia Medica, Rio de Janeiro, RJ (Brazil)

    2015-10-15

    According to the International Atomic Energy Agency (IAEA), a relatively significant number of radiological accidents have occurred in recent years mainly because of the practices referred to as potentially high-risk activities, such as radiotherapy, large irradiators and industrial radiography, especially in gammagraphy assays. In some instances, severe injuries have occurred in exposed persons due to high radiation doses. In industrial radiography, 80 cases involving a total of 120 radiation workers, 110 members of the public including 12 deaths have been recorded up to 2014. Radiological accidents in industrial practices in Brazil have mainly resulted in development of cutaneous radiation syndrome (CRS) in hands and fingers. Brazilian data include 5 serious cases related to industrial gammagraphy, affecting 7 radiation workers and 19 members of the public; however, none of them were fatal. Some methods of reconstructive dosimetry have been used to estimate the radiation dose to assist in prescribing medical treatment. The type and development of cutaneous manifestations in the exposed areas of a person is the first achievable gross dose estimation. This review article presents the state-of-the-art reconstructive dosimetry methods enabling estimation of local radiation doses and provides guidelines for medical handling of the exposed individuals. The review also presents the Chilean and Brazilian radiological accident cases to highlight the importance of reconstructive dosimetry. (author)

  9. Disseminated cutaneous histoplasmosis in an immunocompetent adult

    Directory of Open Access Journals (Sweden)

    Manoj Harnalikar

    2012-01-01

    Full Text Available Histoplasmosis, a systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum var capsulatum and Histoplasma capsulatum var duboisii is endemic to many parts of the world. The clinical manifestations range from acute or chronic pulmonary infection to a progressive disseminated disease. After initial exposure to the fungus, the infection is self-limited and restricted to the lungs in 99% of healthy individuals. The remaining 1%, however, progress to either disseminated or chronic disease involving the lungs, liver, spleen, lymph nodes, bone marrow or rarely, the skin and mucous membranes. Mucocutaneous histoplasmosis is frequently reported in patients with acquired immune deficiency syndrome (AIDS, but it is rare in immunocompetent hosts. A 60-year-old male presented with asymptomatic swelling of the hard palate and crusted papules and nodules over the extremities, face and trunk. Clinically, the diagnoses of cutaneous cryptococcosis versus histoplasmosis was considered in this patient. A chest X-ray revealed hilar lymphadenopathy. Enzyme-linked immunosorbent assay (ELISA for human immunodeficiency virus (HIV was nonreactive. Skin biopsy revealed multiple tiny intracellular round yeast forms with a halo in the mid-dermis. Culture of the skin biopsy in Sabouraud′s dextrose agar showed colonies of Histoplasma capsulatum. Despite an investigation including no evidence of underlying immunosuppression was found, he was started on IV amphotericin-B (0.5 mg/kg/day. However, the patient succumbed to his disease 2 days after presentation. We report a rare case of disseminated cutaneous histoplasmosis in an immunocompetent individual.

  10. Cutaneous Leishmaniasis – Dermoscopic Findings And Cryotherapy

    Directory of Open Access Journals (Sweden)

    Dobrev Hristo P.

    2015-03-01

    Full Text Available We present a 60-year-old male patient who, three months after a holiday in Southern Greece, found a small ‘pimple’ on his back, which gradually got as big as a small walnut, the central part becoming ulcerated and scabby. Dermatological examination found an erythematous-to-livid nodular lesion on the right shoulder; it was 16 mm in diameter with central ulceration, covered with brownish crust which discharged pus-like secretion upon pressure. Microscope examination of Romanowsky-Giemsa stained lesion material detected amastigote forms of Leishmania tropica. The culture investigation and serological tests for leishmaniasis were negative. Dermoscopy of the lesion found the following features: erythema, hyperkeratosis, central ulceration covered with brownish crust, “yellow tears-like” structures and “white starburst-like” patterns, and various vascular structures (including dotted vessels, comma-shaped vessels, hairpin- and glomerular-like vessels. The patient was diagnosed with cutaneous leishmaniasis and underwent four cryotherapy sessions every other week with excellent therapeutic results - complete resolution of infiltrate with subsequent gentle hypopigmented scarring. In conclusion, dermoscopy is an easily accessible non-invasive method which can be useful for the diagnosis of cutaneous leishmaniasis. Cryotherapy is the treatment of choice for single skin lesions.

  11. Anterior cutaneous nerve entrapment syndrome: management challenges

    Science.gov (United States)

    Chrona, Eleni; Kostopanagiotou, Georgia; Damigos, Dimitrios; Batistaki, Chrysanthi

    2017-01-01

    Anterior cutaneous nerve entrapment syndrome (ACNES) is a commonly underdiagnosed and undertreated chronic state of pain. This syndrome is characterized by the entrapment of the cutaneous branches of the lower thoracoabdominal intercostal nerves at the lateral border of the rectus abdominis muscle, which causes severe, often refractory, chronic pain. This narrative review aims to identify the possible therapeutic strategies for the management of the syndrome. Seventeen studies about ACNES therapy were reviewed; of them, 15 were case–control studies, case series, or case reports, and two were randomized controlled trials. The presently available management strategies for ACNES include trigger point injections (diagnostic and therapeutic), ultrasound-guided blocks, chemical neurolysis, and surgical neurectomy, in combination with systemic medication, as well as some emerging techniques, such as radiofrequency ablation and neuromodulation. An increased awareness of the syndrome and the use of specific diagnostic criteria for its recognition are required to facilitate an early and successful management. This review compiles the proposed management strategies for ACNES. PMID:28144159

  12. Reconstructive dosimetry for cutaneous radiation syndrome.

    Science.gov (United States)

    Lima, C M A; Lima, A R; Degenhardt, Ä L; Valverde, N J; Silva, F C A da

    2015-10-01

    According to the International Atomic Energy Agency (IAEA), a relatively significant number of radiological accidents have occurred in recent years mainly because of the practices referred to as potentially high-risk activities, such as radiotherapy, large irradiators and industrial radiography, especially in gammagraphy assays. In some instances, severe injuries have occurred in exposed persons due to high radiation doses. In industrial radiography, 80 cases involving a total of 120 radiation workers, 110 members of the public including 12 deaths have been recorded up to 2014. Radiological accidents in industrial practices in Brazil have mainly resulted in development of cutaneous radiation syndrome (CRS) in hands and fingers. Brazilian data include 5 serious cases related to industrial gammagraphy, affecting 7 radiation workers and 19 members of the public; however, none of them were fatal. Some methods of reconstructive dosimetry have been used to estimate the radiation dose to assist in prescribing medical treatment. The type and development of cutaneous manifestations in the exposed areas of a person is the first achievable gross dose estimation. This review article presents the state-of-the-art reconstructive dosimetry methods enabling estimation of local radiation doses and provides guidelines for medical handling of the exposed individuals. The review also presents the Chilean and Brazilian radiological accident cases to highlight the importance of reconstructive dosimetry.

  13. Reconstructive dosimetry for cutaneous radiation syndrome

    Directory of Open Access Journals (Sweden)

    C.M.A. Lima

    2015-01-01

    Full Text Available According to the International Atomic Energy Agency (IAEA, a relatively significant number of radiological accidents have occurred in recent years mainly because of the practices referred to as potentially high-risk activities, such as radiotherapy, large irradiators and industrial radiography, especially in gammagraphy assays. In some instances, severe injuries have occurred in exposed persons due to high radiation doses. In industrial radiography, 80 cases involving a total of 120 radiation workers, 110 members of the public including 12 deaths have been recorded up to 2014. Radiological accidents in industrial practices in Brazil have mainly resulted in development of cutaneous radiation syndrome (CRS in hands and fingers. Brazilian data include 5 serious cases related to industrial gammagraphy, affecting 7 radiation workers and 19 members of the public; however, none of them were fatal. Some methods of reconstructive dosimetry have been used to estimate the radiation dose to assist in prescribing medical treatment. The type and development of cutaneous manifestations in the exposed areas of a person is the first achievable gross dose estimation. This review article presents the state-of-the-art reconstructive dosimetry methods enabling estimation of local radiation doses and provides guidelines for medical handling of the exposed individuals. The review also presents the Chilean and Brazilian radiological accident cases to highlight the importance of reconstructive dosimetry.

  14. Plasmacytoid dendritic cell role in cutaneous malignancies.

    Science.gov (United States)

    Saadeh, Dana; Kurban, Mazen; Abbas, Ossama

    2016-07-01

    Plasmacytoid dendritic cells (pDCs) correspond to a specialized dendritic cell population that exhibit plasma cell morphology, express CD4, CD123, HLA-DR, blood-derived dendritic cell antigen-2 (BDCA-2), and Toll-like receptor (TLR)7 and TLR9 within endosomal compartments. Through their production of type I interferons (IFNs) and other pro-inflammatory cytokines, pDCs provide anti-viral resistance and link the innate and adaptive immunity by controlling the function of myeloid DCs, lymphocytes, and natural killer (NK) cells. While lacking from normal skin, pDCs are usually recruited to the skin in several cutaneous pathologies where they appear to be involved in the pathogenesis of several infectious, inflammatory/autoimmune, and neoplastic entities. Among the latter group, pDCs have the potential to induce anti-tumour immunity; however, the complex interaction of pDCs with tumor cells and their micro-environment appears to contribute to immunologic tolerance. In this review, we aim at highlighting the role played by pDCs in cutaneous malignancies with special emphasis on the underlying mechanisms.

  15. Cutaneous Complications of Targeted Melanoma Therapy.

    Science.gov (United States)

    de Golian, Emily; Kwong, Bernice Y; Swetter, Susan M; Pugliese, Silvina B

    2016-11-01

    The landscape of advanced and metastatic melanoma therapy has shifted dramatically in recent years. Since 2011, eight drugs (ipilimumab, vemurafenib, dabrafenib, trametinib, cometinib, pembrolizumab, nivolumab, and talimogene laherparepvec) have received FDA approval for the treatment of advanced or metastatic melanoma, including combination regimens of both small molecule kinase and immune checkpoint inhibitors. These therapies have revolutionized the management of unresectable regional nodal and distant melanoma, providing hope of extended survival to patients. As the use of novel agents has increased, so have the cutaneous toxicities associated with these medications. While most skin reactions are low-grade and can be managed conservatively with topical therapies, malignant lesions and more serious or life-threatening drug reactions can arise during therapy, requiring prompt dermatologic recognition and treatment in order to improve patient outcome. Given the survival benefit attributed to these new agents, treating skin toxicity and maintaining patient quality of life is of paramount importance. Oncologists should be aware of the common cutaneous toxicities associated with these medications and should be encouraged to involve dermatologists in the collaborative care of advanced melanoma patients. Close communication between oncologists and dermatologists can help to avoid unnecessary dose reduction or treatment discontinuation and identify situations when treatment cessation is truly warranted.

  16. Cutaneous mucormycosis secondary to penetrative trauma.

    Science.gov (United States)

    Zahoor, Bilal; Kent, Stephen; Wall, Daryl

    2016-07-01

    Mucormycosis is a rare but serious sequelae of penetrating trauma [1-5]. In spite of aggressive management, mortality remains high due to dissemination of infection. We completed a review of literature to determine the most optimal treatment of cutaneous mucormycosis which occurs secondary to penetrating trauma. We completed a review regarding the management of mucormycosis in trauma patients. We selected a total of 36 reports, of which 18 were case-based, for review. Surgical debridement is a primary predictor of improved outcomes in the treatment of mucormycosis [3,6,7]. Anti-fungal therapy, especially lipid soluble formulation of Amphotericin B, is helpful as an adjunct or when surgical debridement has been maximally achieved. Further research is needed to fully evaluate the impact of topical dressings; negative pressure wound therapy is helpful. An aggressive and early surgical approach, even at the expense of disfigurement, is necessary to reduce mortality in the setting of cutaneous mucormycosis that results from penetrating trauma [4,8,9]. Anti-fungal therapy and negative pressure wound therapy are formidable adjuncts. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Molecular Bases of Cutaneous and Uveal Melanomas

    Directory of Open Access Journals (Sweden)

    Sudeep Gaudi

    2011-01-01

    Full Text Available Intensive research in recent years has begun to unlock the mysteries surrounding the molecular pathogenesis of melanoma, the deadliest of skin cancers. The high-penetrance, low-frequency susceptibility gene CDKN2A produces tumor suppressor proteins that function in concert with p53 and retinoblastoma protein to thwart melanomagenesis. Aberrant CDKN2A gene products have been implicated in a great many cases of familial cutaneous melanoma. Sporadic cases, on the other hand, often involve constitutive signal transduction along the mitogen-activated protein kinase (MAPK pathway, with particular focus falling upon mutated RAS and RAF protooncogenes. The proliferative effects of the MAPK pathway may be complemented by the antiapoptotic signals of the PI3K/AKT pathway. After skin, melanoma most commonly affects the eye. Data for the constitutive activation of the MAPK pathway in uveal melanoma exists as well, however, not through mutations of RAS and RAF. Rather, evidence implicates the proto-oncogene GNAQ. In the following discussion, we review the major molecular pathways implicated in both familial and sporadic cutaneous melanomagenesis, the former accounting for approximately 10% of cases. Additionally, we discuss the molecular pathways for which preliminary evidence suggests a role in uveal melanomagenesis.

  18. DNS and LES of some engineering flows

    Science.gov (United States)

    Rodi, Wolfgang

    2006-02-01

    In this paper, direct numerical simulations (DNS) and large eddy simulations (LES) of three engineering flows carried out in the author's research group are presented. The first example, simulated both with DNS and LES, is the flow in a low-pressure turbine cascade with wakes passing periodically through the cascade channel. In this situation, the laminar-turbulent transition of the boundary layers on the blade surfaces, which is strongly influenced by the passing wakes, is of special interest. Next, LES of the flow past the Ahmed body is presented, which is a car model with slant back. In spite of the fairly simple geometry, the flow around the model has many features of the complex, fully 3D flow around real cars. The third example, for which LES is presented, is the flow past a surface mounted circular cylinder of height-to-diameter ratio of 2.5. In this case also complex 3D flow develops with interaction of various vortices behind the cylinder. By means of these examples, the paper shows that complex turbulent flows of engineering relevance can be predicted realistically by DNS and LES, albeit at large cost. The methods are particularly suited and superior to RANS methods for situations where unsteadiness like shedding and large-scale structures dominate the flow, and DNS has evolved into an important tool for studying transition mechanisms.

  19. LES of Gas Exchange in IC Engines

    Directory of Open Access Journals (Sweden)

    Mittal V.

    2013-10-01

    Full Text Available As engine technologies become increasingly complex and engines are driven to new operating points, understanding transient phenomena is important to ensure reliable engine operation. Unlike Reynolds Averaged Navier-Stokes (RANS studies that only provide cycle-averaged information, Large Eddy Simulation (LES studies are capable of simulating cycle-to-cycle dynamics. In this work, a finite difference based structured methodology for LES of IC engines is presented. This structured approach allows for an efficient mesh generation process and provides potential for higher order numerical accuracy. An efficient parallel scalable block decomposition is done to overcome the challenges associated with the low ratio of fluid elements to overall mesh elements. The motion of the valves and piston is handled using a dynamic cell blanking approach and the Arbitrary Lagrangian Eulerian (ALE method, respectively. Modified three-dimensional Navier-Stokes Characteristic Boundary Conditions (NSCBC are used in the simulation to prescribe conditions in the manifolds. The accuracy of the simulation framework is validated using various canonical configurations. Flow bench simulations of an axisymmetric configuration and an actual engine geometry are done with the LES methodology. Simulations of the gas exchange in an engine under motored conditions are also performed. Overall, good agreement is obtained with experiments for all the cases. Therefore, this framework can be used for LES of engine simulations. In the future, reactive LES simulations will be performed using this framework.

  20. Les collections de modèles anatomiques équins de Louis Auzoux, une collection à constituer

    OpenAIRE

    Degueurce, Christophe

    2015-01-01

    Le docteur Louis Auzoux (1797-1880) est bien connu pour les mannequins anatomiques de papier qu’il produisit et exporta dans le monde entier. Si les modèles se rapportant à l’homme ont une force esthétique qui leur a donné une visibilité prépondérante, ils sont loin d’être les seuls que le célèbre industriel a conçus et commercialisés ; les animaux, les végétaux et tout particulièrement les fleurs, constituent une autre facette de son art. Mais les modèles dédiés au cheval eurent une importan...

  1. Herder et les Lumières

    OpenAIRE

    2011-01-01

    Si Herder construit sa pensée en s’opposant à l’hégémonie voltairienne sur l’Allemagne, c’est aussi en fréquentant très précisément Jean-Jacques Rousseau ou encore Helvétius et d’Alembert, les écrits de Hume ou les chants d’Ossian, qu’il conduit sa réflexion à sa pleine maturité. Les philosophies française et écossaise jouent dans son évolution un rôle décisif. Des chercheurs européens ont réuni leurs efforts pour souligner la dimension cosmopolite de Herder. L’élargissement géographique de l...

  2. Les actionnaires salariés

    OpenAIRE

    Philippe Desbrières

    2002-01-01

    L'actionnariat est l'une des formules de participation financière utilisées pour stimuler les efforts des salariés. Il leur permet de constituer un portefeuille de valeurs mobilières et d'acquérir, souvent dans des conditions avantageuses, des actions de la société qui les emploie. Mais il conduit les salariés à y assumer un double statut : d'apporteur de capital humain d'une part, d'apporteur de ressources financières d'autre part. Se pose alors de manière accrue le problème de la sauvegarde...

  3. Les consequences de Tchernobyl et la sociopathologie

    Directory of Open Access Journals (Sweden)

    Laurent Bocéno

    2006-06-01

    Full Text Available Dans la situation de post-catastrophe aux alentours de Tchernobyl, la vie quotidienne est une correspondance constante entre l'institué et le vécu qui sont souvent analysés séparément. Avec l'approche par les sociopathologies, il est possible d'examiner le social entré dans le corps comme le résultat de l'intériorisation en nous, d'archétypes sociaux d'une part et d'autre part, de situations incorporées. Les sociopathologies sont liées aux formes d'institutionnalisation dont le sens est souvent ignoré par les personnes qui y sont confrontées.

  4. Les traditions céramiques dogon

    OpenAIRE

    Gallay, Alain; Kalapo, Y.; Guindo, E.

    2006-01-01

    Le Pays dogon est réputé pour ses traditions artisanales. Depuis une dizaine d'années, nous nous sommes donnés pour tâche d'étudier l'artisanat de la poterie, aujourd'hui en cours de disparition sous la pression de la diffusion de la vaisselle métallique d'origine industrielle, et de dresser un tableau complet des traditions céramiques du Pays dogon. Notre intérêt s'est porté plus particulièrement sur les relations existant entre les différentes traditions et les principales communautés dogon...

  5. Les métamorphoses du pouvoir

    OpenAIRE

    Adler, Alfred

    2004-01-01

    On sait que la sorcellerie en Afrique peut s'exercer du faible au fort ou l'inverse. Les situations qui sont ici analysées sont celles où les rois ou les chefs sont expressément désignés comme sorciers, soit qu'ils le deviennent du fait même de leur investiture, soit qu'il leur ait fallu le devenir pour accéder au pouvoir et le conserver face à des rivaux usant des mêmes moyens. Quoi qu'il en soit, un roi-sorcier offre une figure paradoxale du pouvoir, et cela doublement : garant de l'...

  6. Retour sur les images d’organisations

    OpenAIRE

    Laborde, Aurélie; Mahy, Isabelle; Soubiale, Nadège

    2011-01-01

    Depuis les années 1970, les sciences de gestion et la littérature managériale se sont emparées du vocable d’image pour traduire un ensemble de conduites et de stratégies éparses des organisations soumises aux aléas de la concurrence et de la dérégulation des marchés. Construite et projetée par l’organisation, l’image se fait image de marque, communication institutionnelle et corporative, stratégie de valorisation de l’image des entreprises. Perçue et interprétée par les acteurs et l’environn...

  7. Chapitre II. Les madréporaires

    OpenAIRE

    Service mixte de surveillance radiologique et biologique,

    2013-01-01

    On emploie couramment le terme de corail pour désigner les organismes sécrétant le squelette calcaire blanc que l’on observe sur les récifs. A vrai dire, employé dans ce sens, le terme corail est impropre. Le véritable corail est le corail rouge : Corallium rubrum vivant en Méditerranée et au Japon et dont le squelette branchu sert à la fabrication des bracelets et des colliers. Le corail des récifs est désigné par les naturalistes sous le terme de Madréporaires ou de Scléractiniaires. Dans l...

  8. Deux livres pour penser les sciences

    Directory of Open Access Journals (Sweden)

    Laurent Matthey

    2008-06-01

    Full Text Available Qu’est-ce que la science ? Existe-t-il, entre les différentes disciplines, des éléments qui permettent de parler d’une science au singulier ? Ou le pluriel est-il de rigueur, l’éclatement des traditions et habitudes de recherche nécessitant que l’on parle plutôt de sciences ? Quel est le rapport que la pratique scientifique entretient avec le réel ? Les théories que livrent les chercheurs décrivent-elles un monde externe ? Ne font-elles que cela ? On bien faut-il voir ces théories comme des «...

  9. Prevalence of Cutaneous Leishmaniasis in Ramshir, Iran; an Epidemiological Study

    Directory of Open Access Journals (Sweden)

    Vazirianzadeh B.* PhD,

    2014-08-01

    Full Text Available Aims Cutaneous leishmaniasis is a prevalent parasitological disease with diverse clinical manifestations in Iran. Therefore, the present retrospective study carried out to describe the demographic features of cutaneous leishmaniasis in Ramshir, Iran. Materials & Methods This descriptive study was performed on 136 cutaneous leishmaniasis patients whose data were recorded in the Ramshir health center during 2006-9. Demographic information of patients including age, sex, habitat and sites of lesions, month and years of incidence were recorded. The data were analyzed by SPSS 16 software. Findings Totally 79 patients (58.1% resided in urban areas and the born to 9 years (49.3% was recognized as the most infected age group. Hands (41.2% had the highest rates of cutaneous leishmaniasis lesions followed by face (36.0% and foot (22.8%. The maximum number of cutaneous leishmaniasis lesions was reported in March. Conclusion As cutaneous leishmaniasis in Ramshir seemed to be an endemic rural type, the appropriate preventing measures regarding to the rural cutaneous leishmaniasis should be considered to decrease incidence of the disease in the region.

  10. Adverse Cutaneous Reactions to Psychotropic Drugs: A Review

    Directory of Open Access Journals (Sweden)

    Filipa Novais

    2015-11-01

    Full Text Available Introduction: Psychotropic drugs are often implicated in cutaneous adverse drug reactions. While most of these reactions have a benign character, it is still important, however, to consider its role in the increasing stigma and treatment adherence. A small number of the cutaneous adverse drug reactions can develop into serious and potentially fatal conditions. Objectives: This article aims to review the most common cutaneous adverse drug reactions in patients taking psychotropic drugs. Methods: In this study, a search was carried out in the MEDLINE database for English language articles published , from 1999 to 2014, using as keywords: psychiatric, psychotropic, cutaneous, adverse reaction, antidepressive agents, antipsychotics, benzodiazepines, mood stabilizers, anticonvulsant, dementia. Information available from the Portuguese regulatory and supervising agency (Infarmed was also included.Results: 121 articles were found with reference to cutaneous adverse drug reactions associated with psychotropic drugs. The drugs most frequently reported as associated with such adverse effects were anticonvulsants used as mood stabilizers, followed by the antipsychotics . The antidementia drugs were rarely associated with serious cutaneous adverse reactions. Discussion and Conclusion: Cutaneous drug adverse reactions are common in psychiatric clinical practice and typically are minor in severity. The most severe reactions are most often associated with the use of mood stabilizing medications. Some of these side effects can be solved with reduction or drug discontinuation. More severe cases should be referred to a specialist in dermatology.

  11. Approach to cutaneous lymphoid infiltrates: When to consider lymphoma?

    Directory of Open Access Journals (Sweden)

    Yann Vincent Charli-Joseph

    2016-01-01

    Full Text Available Cutaneous lymphoid infiltrates (CLIs are common in routine dermatopathology. However, differentiating a reactive CLI from a malignant lymphocytic infiltrate is often a significant challenge since many inflammatory dermatoses can clinically and/or histopathologically mimic cutaneous lymphomas, coined pseudolymphomas. We conducted a literature review from 1966 to July 1, 2015, at PubMed.gov using the search terms: Cutaneous lymphoma, cutaneous pseudolymphoma, cutaneous lymphoid hyperplasia, simulants/mimics/imitators of cutaneous lymphomas, and cutaneous lymphoid infiltrates. The diagnostic approach to CLIs and the most common differential imitators of lymphoma is discussed herein based on six predominant morphologic and immunophenotypic, histopathologic patterns: (1 Superficial dermal T-cell infiltrates (2 superficial and deep dermal perivascular and/or nodular natural killer/T-cell infiltrates (3 pan-dermal diffuse T-cell infiltrates (4 panniculitic T-cell infiltrates (5 small cell predominant B-cell infiltrates, and (6 large-cell predominant B-cell infiltrates. Since no single histopathological feature is sufficient to discern between a benign and a malignant CLI, the overall balance of clinical, histopathological, immunophenotypic, and molecular features should be considered carefully to establish a diagnosis. Despite advances in ancillary studies such as immunohistochemistry and molecular clonality, these studies often display specificity and sensitivity limitations. Therefore, proper clinicopathological correlation still remains the gold standard for the precise diagnosis of CLIs.

  12. Approach to Cutaneous Lymphoid Infiltrates: When to Consider Lymphoma?

    Science.gov (United States)

    Charli-Joseph, Yann Vincent; Gatica-Torres, Michelle; Pincus, Laura Beth

    2016-01-01

    Cutaneous lymphoid infiltrates (CLIs) are common in routine dermatopathology. However, differentiating a reactive CLI from a malignant lymphocytic infiltrate is often a significant challenge since many inflammatory dermatoses can clinically and/or histopathologically mimic cutaneous lymphomas, coined pseudolymphomas. We conducted a literature review from 1966 to July 1, 2015, at PubMed.gov using the search terms: Cutaneous lymphoma, cutaneous pseudolymphoma, cutaneous lymphoid hyperplasia, simulants/mimics/imitators of cutaneous lymphomas, and cutaneous lymphoid infiltrates. The diagnostic approach to CLIs and the most common differential imitators of lymphoma is discussed herein based on six predominant morphologic and immunophenotypic, histopathologic patterns: (1) Superficial dermal T-cell infiltrates (2) superficial and deep dermal perivascular and/or nodular natural killer/T-cell infiltrates (3) pan-dermal diffuse T-cell infiltrates (4) panniculitic T-cell infiltrates (5) small cell predominant B-cell infiltrates, and (6) large-cell predominant B-cell infiltrates. Since no single histopathological feature is sufficient to discern between a benign and a malignant CLI, the overall balance of clinical, histopathological, immunophenotypic, and molecular features should be considered carefully to establish a diagnosis. Despite advances in ancillary studies such as immunohistochemistry and molecular clonality, these studies often display specificity and sensitivity limitations. Therefore, proper clinicopathological correlation still remains the gold standard for the precise diagnosis of CLIs.

  13. Toxigenic cutaneous diphtheria in a returned traveller.

    Science.gov (United States)

    Abdul Rahim, Nur R; Koehler, Ann P; Shaw, Doug D; Graham, Caitlin R

    2014-12-31

    Diphtheria is rarely reported in Australia. A case of cutaneous diphtheria was reported to the South Australian Department for Health and Ageing in April 2013 in an Australian-born 18-year-old female following travel in India. The case presented with a skin ulcer on her toe. Toxigenic Corynebacterium diphtheriae was isolated from a swab of the lesion. The case was treated with antibiotics. The public health response included infection control advice, assessing the case and household contacts for organism carriage and providing antimicrobial chemoprophylaxis to contacts. Although cutaneous diphtheria is not included as part of the Australian communicable disease surveillance case definition, this may be an oversight as international evidence demonstrates that it is a source of organism transmission and can potentially result in outbreaks among susceptible populations. This formed the rationale for the public health response to this particular case. The protocol for the public health management of diphtheria in South Australia has since been revised to include cutaneous lesions caused by the toxigenic strain of the organism as part of the surveillance case definition. This work is copyright. You may download, display, print and reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as permitted by the Copyright Act 1968 or allowed by this copyright notice, all other rights are reserved and you are not allowed to reproduce the whole or any part of this work in any way (electronic or otherwise) without first being given the specific written permission from the Commonwealth to do so. Requests and inquiries concerning reproduction and rights are to be sent

  14. Peuplement et environnement dans les Guyanes

    OpenAIRE

    Versteeg, Aad

    2013-01-01

    Les chasseurs (paléo-indiens) Les premiers habitants du Nord de l’Amérique du Sud étaient des chasseurs de mégafaune au Venezuela occidental, à l’ouest du Plateau des Guyanes. Ils appartiennent à la culture El Jobo, datée entre 14000 et 12000 BP. Deux autres cultures paléo-indiennes similaires lui correspondent : la culture Canaima du haut Caroni au Venezuela oriental, et la culture Sipaliwini dans le sud du Surinam (Boomert, 1980). Ces trois cultures ont notamment en commun l’utilisation de ...

  15. Les TIC, un monde à partager

    OpenAIRE

    Daignault, Jacques

    2005-01-01

    L'Association québécoise des utilisateurs de l'ordinateur au primaire-secondaire (AQUOPS) a tenu son colloque annuel les 22, 23 et 24 mars 2005 sur le thème Les TIC, un monde à partager. Le thème mérite une réflexion invitant à la participation et à la mise en place d'un forum très large sur la protection de la connaissance comme bien commun et universel.

  16. Les transformations du jeûne chez les chrétiens d'Orient

    Directory of Open Access Journals (Sweden)

    Bernard Heyberger

    2006-11-01

    Full Text Available Dans le christianisme, les règles du jeûne et de l’abstinence sont extrêmement complexes, dans leur rythme annuel et dans leurs prescriptions alimentaires, ce qui les distingue nettement de la pratique musulmane. C’est peut-être davantage dans l’anthropologie sous-jacente qu’on pourrait déterminer des conceptions communes aux deux religions. Ces règles se sont élaborées progressivement, entre le ive et le xiiie siècle, différenciant les Églises orientales de l’Église romaine, mais introduisant aussi des distinctions entre Églises orientales rivales. Il est assez difficile de se former une opinion claire sur les prescriptions et sur leur application concrète dans chaque groupe de chrétiens.À partir du xviie siècle, les Églises orientales se voient interrogées à propos de leurs pratiques en matière de jeûne et d’abstinence par les missionnaires et les érudits latins, et sommées de définir des règles strictes et définitives. En même temps, l’introduction des références du catholicisme latin fait perdre le sens du jeûne comme oeuvre collective, au profit d’une ascèse personnelle et intériorisée, centrée sur la pratique des sacrements. Les transformations du jeûne deviennent alors symptôme de la « modernisation » en cours chez les chrétiens orientaux.

  17. Penser les métropoles pour les « individus » ?

    Directory of Open Access Journals (Sweden)

    Marc Dumont

    2006-03-01

    Full Text Available Les instruments dont on dispose aujourd’hui pour décrire et expliquer les réalités métropolitaines contemporaines ne sont pas entièrement satisfaisants : ils ne permettent pas toujours d’identifier les vraies questions qui se présentent à ceux qui produisent la ville. Partant de ce constat, le sociologue Alain Bourdin synthétise dans son nouvel essai des réflexions issues de sa pratique de recherche et de dialogue avec le monde des institutions, pour y proposer une lecture de la ...

  18. Les écrits comme supports de raisonnement dans les exploitations d'élevage

    OpenAIRE

    Havet, Alain; Joly, Nathalie; Cochet, A.

    2005-01-01

    Nombre d’initiatives propose aux agriculteurs des outils, souvent informatiques, pour faciliter la fourniture à des tiers d’une part grandissante d’information, le plus souvent sans tenir compte des notations déjà mises en place dans les exploitations. Notre objectif est ici de repositionner l’agriculteur comme principal bénéficiaire d’un système d’information dont il aurait la pleine maîtrise. Nous avons choisi de nous intéresser au lien entre les raisonnements et les écrits disponibles pour...

  19. Les quarante heures dans les mines de charbon sous le Front populaire

    OpenAIRE

    Philippe, Aurélie

    2015-01-01

    Le principe de la semaine de quarante heures, diminution du temps de travail sans diminution des salaires, apparaît dans les travaux de l’O.I.T. (Organisation internationale du Travail) comme une solution à la crise économique des années 1930. Le Front populaire reprend cette mesure et promulgue la loi sur la semaine de quarante heures le 21 juin 1936. L’étude de son application, au jour le jour, dans un secteur et une région spécifique, les mines de charbon du Nord-Pas-de-Calais, nuance les ...

  20. A case of cutaneous paragonimiasis presented with minimal pleuritis.

    Science.gov (United States)

    Singh, T Shantikumar; Devi, Kh Ranjana; Singh, S Rajen; Sugiyama, Hiromu

    2012-07-01

    Clinically, paragonimiasis is broadly classified into pulmonary, pleuropulmonary, and extrapulmonary forms. The common extrapulmonary forms are cerebral and cutaneous paragonimiasis. The cutaneous paragonimiasis is usually presented as a slowly migrating and painless subcutaneous nodule. The correct diagnosis is often difficult or delayed or remained undiagnosed until the nodule becomes enlarged and painful and the cause is investigated. We report here a case of cutaneous paragonimiasis in a male child who presented with mild respiratory symptoms. The diagnosis of paragonimiasis was based on a history of consumption of crabs, positive specific serological test, and blood eosinophilia. The swelling and respiratory symptoms subsided after a prescribed course of praziquantel therapy.

  1. Primary Cutaneous Chrysosporium Infection following Ear Piercing: A Case Report

    Directory of Open Access Journals (Sweden)

    Poonkiat Suchonwanit

    2015-07-01

    Full Text Available Chrysosporium is a large genus of saprophytic fungi that is commonly found in the soil. Infection caused by this organism is rare in humans and typically occurs in immunocompromised patients. Primary cutaneous Chrysosporium infection is relatively rare and has been reported in a heart transplant patient. The prognosis is usually favorable, but very poor in the setting of persistent profound immunosuppression. We herein report a case of primary cutaneous Chrysosporium infection following ear piercing in an immunocompetent patient. It is important for clinicians to consider this condition in patients with slow-onset skin and soft tissue infection following cutaneous injury, even in an immunocompetent setting.

  2. Multiple cutaneous melanomas associated with gastric and brain metastases*

    Science.gov (United States)

    Grander, Lara Caroline; Cabral, Fernanda; Lisboa, Alice Paixão; Vale, Gabrielle; Barcaui, Carlos Baptista; Maceira, Juan Manuel Pineiro

    2016-01-01

    The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.

  3. Cellular requirements for cutaneous sensitivity elicitation.

    Science.gov (United States)

    Aoki, I

    1985-01-01

    The role of glass-adherent cells in cutaneous sensitivity (CS) elicitation has been analyzed in this study. CS responses have been revealed to be mediated by at least two distinct subsets of genetically restricted T cells: I-restricted 'DTH-like' T cells and K/D-restricted 'CTL-like' T cells. Both T-cell responses require I-A-positive glass-adherent cell populations, which lack T-cell markers, to manifest their activities. The role of the adherent cells is different in the 'DTH-like' responses and the 'CTL-like' responses. The disparities between the present results and previous contentions are discussed in this paper.

  4. Cutaneous changes in fibrous hamartoma of infancy

    Directory of Open Access Journals (Sweden)

    Pilar F-Eire

    2013-01-01

    Full Text Available Only a few published case of fibrous hamartoma of infancy (FHI have commented on the changes in the overlying skin. There are descriptions of individual cases with cutaneous hyperpigmentation, hypertrichosis and hyperhidrosis. It is interesting to describe our case because, to our knowledge, the altered pigmentation of the overlying skin, with hairs on the surface, and eccrine gland hyperplasia combined with abortive hair follicles has not been reported together in association with the FHI. We recommend that all the biopsies must be excisional including overlying skin, thus the epidermal and dermal adnexal changes can be assessed in the microscopic evaluation which could have relevant implications from clinical and embryological point of view.

  5. Sun behaviour after cutaneous malignant melanoma

    DEFF Research Database (Denmark)

    Idorn, L W; Datta, P; Heydenreich, J

    2013-01-01

    Background  It has been reported that patients with cutaneous malignant melanoma (CMM) can lower their risk of a second primary melanoma by limiting recreational sun exposure. Previous studies based on questionnaires and objective surrogate measurements indicate that before their diagnosis......, patients with CMM are exposed to higher ultraviolet radiation (UVR) doses than controls, followed by a reduction after diagnosis. Objectives  In a prospective, observational case-control study, we aimed to assess sun exposure after diagnosis of CMM by objective measurements to substantiate advice about sun...... months and 6 years before the start of the study. During a summer season participants filled in sun exposure diaries daily and wore personal electronic UVR dosimeters in a wristwatch that continuously measured time-stamped UVR doses in standard erythema dose. Results  The UVR dose of recently diagnosed...

  6. Influence of microemulsions on cutaneous drug delivery

    DEFF Research Database (Denmark)

    Kreilgaard, Mads

    2002-01-01

    In attempt to increase cutaneous drug delivery, microemulsion vehicles have been more and more frequently employed over recent years. Microemulsion formulations have been shown to be superior for both transdermal and dermal delivery of particularly lipophilic compounds, but also hydrophilic...... compounds appear to benefit from application in microemulsions compared to conventional vehicles, like hydrogels, emulsions and liposomes. The favourable drug delivery properties of microemulsions appear to mainly be attributed to the excellent solubility properties. However, the vehicles may also act...... as penetration enhancers depending on the oil/surfactant constituents, which involves a risk of inducing local irritancy. The correlation between microemulsion structure/composition and drug delivery potential is not yet fully elucidated. However, a few studies have indicated that the internal structure...

  7. Diffuse cutaneous bullous mastocytosis in a newborn.

    Science.gov (United States)

    Wawrzycki, Bartłomiej; Pietrzak, Aldona; Chodorowska, Grażyna; Kanitakis, Jean

    2013-01-01

    Diffuse cutaneous mastocytosis is the rarest subtype of mastocytosis among those that affect children. A 7-month-old girl presented at birth dry and thickened skin. On the second day of life, tense blisters appeared on erythrodermic areas and during the next days spread over the face, trunk, and limbs. The skin was bright red, had a "peau d'orange" appearance, and was considerably thickened with numerous translucent and hemorrhagic blisters. A skin biopsy revealed massive infiltration of the dermis with mast cells, leading to the diagnosis of diffuse erythrodermic mastocytosis. Systemic corticosteroids were given along with antihistamines with good results. Despite the progresses in the understanding of pathogenesis, genetics, and diagnostic criteria of mastocytosis, clear and reliable prognostic markers are still lacking, especially in order to predict systemic involvement. not only in diffuse but also in the commoner forms of the disease.

  8. Posterior antebrachial cutaneous neuropathy. Case report.

    Science.gov (United States)

    Chang, C W; Oh, S J

    1990-01-01

    Posterior antebrachial cutaneous (PABC) neuropathy is rare. Two original cases are reported here. In case 1, the neuropathy is probably due to a traction injury in a reduction operation for humeral fracture. In case 2, it is injured associately with an operation in taking a myocutaneous flap. On examination, both cases showed a decreased sensation to pin-prick over the PABC nerve territories and a positive Tinel's sign near the injured sites. Sensory nerve conduction study of the PABC nerves revealed a low amplitude of the compound nerve action potential (CNAP) and a slow sensory nerve conduction velocity (SNCV) in case 1, and absent CNAP in case 2. Our study showed the sensory nerve conduction test is useful in confirming PABC neuropathy.

  9. Unusual Presentation of Cutaneous Leishmaniasis: Ocular Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Masoud Doroodgar

    2017-01-01

    Full Text Available The leishmaniases are parasitic diseases that are transmitted to humans by infected female sandflies. Cutaneous leishmaniasis (CL is one of 3 main forms of the disease. CL is the most common form of the disease and is endemic in many urban and rural parts of Iran and usually caused by two species of Leishmania: L. major and L. tropica. We report a case of unusual leishmaniasis with 25 lesions on exposed parts of the body and right eyelid involvement (ocular leishmaniasis. The patient was a 75-year-old male farmer referred to health care center in Aran va Bidgol city. The disease was diagnosed by direct smear, culture, and PCR from the lesions. PCR was positive for Leishmania major.

  10. The genomic landscape of cutaneous melanoma.

    Science.gov (United States)

    Zhang, Tongwu; Dutton-Regester, Ken; Brown, Kevin M; Hayward, Nicholas K

    2016-05-01

    Somatic mutation analysis of melanoma has been performed at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last 5 yr, next-generation sequencing (NGS) has enabled even more comprehensive mutational screening at the level of multigene panels, exomes and genomes. These studies have uncovered many new and unexpected players in melanoma development. The recent landmark study from The Cancer Genome Atlas (TCGA) consortium describing the genomic architecture of 333 cutaneous melanomas provides the largest and broadest analysis to date on the somatic aberrations underlying melanoma genesis. It thus seems timely to review the mutational landscape of melanoma and highlight the key genes and cellular pathways that appear to drive this cancer.

  11. Pattern of cutaneous manifestations in diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Goyal Abhishek

    2010-01-01

    Full Text Available Background: Diabetes mellitus affects individuals of all ages and socioeconomic status. Skin is affected by the acute metabolic derangements as well as by chronic degenerative complications of diabetes. Aims: To evaluate the prevalence of skin manifestations in patients with diabetes mellitus. To analyze the prevalence and pattern of skin disorders among diabetic patients from this region of Western Himalayas. Materials and Methods: One hundred consecutive patients with the diagnosis of diabetes mellitus and having skin lesions, either attending the diabetic clinic or admitted in medical wards were included in this study. Results: The common skin disorders were: x0 erosis (44%, diabetic dermopathy (36%, skin tags (32%, cutaneous infections (31%, and seborrheic keratosis (30%. Conclusion: Skin is involved in diabetes quite often and the manifestations are numerous. High prevalence of xerosis in our diabetic population is perhaps due to cold and dry climatic conditions in the region for most of the time in the year.

  12. Anastrozole-induced subacute cutaneous lupus erythematosus.

    Science.gov (United States)

    Fisher, Juliya; Patel, Mital; Miller, Michael; Burris, Katy

    2016-08-01

    Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) has been associated with numerous drugs, but there are limited reports of its association with aromatase inhibitor anastrozole. We report the case of a patient undergoing treatment with anastrozole for breast cancer who presented with clinical, serological, and histological evidence consistent with DI-SCLE. Her condition quickly began to improve after the use of anastrozole was discontinued and hydroxychloroquine therapy was initiated. Cases such as ours as well as several others that implicate antiestrogen drugs in association with DI-SCLE seem to be contradictory to studies looking at the usefulness of treating systemic lupus erythematosus (SLE) with antiestrogen therapy. Further research on this relationship is warranted.

  13. Proteome Profiling of Human Cutaneous Leishmaniasis Lesion

    Science.gov (United States)

    da Silva Santos, Claire; Attarha, Sanaz; Saini, Ravi Kanth; Boaventura, Viviane; Costa, Jackson; Khouri, Ricardo; Barral-Netto, Manoel; Brodskyn, Cláudia Ida; Souchelnytskyi, Serhiy

    2015-01-01

    In this study, we used proteomics and biological network analysis to evaluate the potential biological processes and components present in the identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis in comparison with normal skin. We identified 59 proteins differently expressed in samples from infected and normal skin. Biological network analysis employing identified proteins showed the presence of networks that may be involved in the cell death mediated by cytotoxic T lymphocytes. After immunohistochemical analyses, the expression of caspase-9, caspase-3, and granzyme B was validated in the tissue and positively correlated with the lesion size in CL patients. In conclusion, this work identified differentially expressed proteins in the inflammatory site of CL, revealed enhanced expression of caspase-9, and highlighted mechanisms associated with the progression of tissue damage observed in lesions. PMID:25207817

  14. Cutaneous necrotizing vasculitis. Relation to systemic disease.

    Science.gov (United States)

    Lotti, T M; Comacchi, C; Ghersetich, I

    1999-01-01

    Cutaneous necrotizing vasculitis (CNV) is a complex multisystem disease generally involving the skin and mucous membranes, often accompanied by renal, gastrointestinal, pericardial, neurological, and articular signs and symptoms. CNV may be idiopatical or occur in association with a drug, infection, or underlying disease. CNV has been shown in patients with chronic infections (viral, bacterial, protozoa, helminthic), serum sickness, a variety of collagen vascular diseases (systemic lupus erythematous, Sjögren's syndrome, rheumatoid arthritis, Behçet's disease) hyperglobulinemic states, cryoglobulinemia, bowel bypass syndrome, ulcerative colitis, cystic fibrosis, primary biliary cirrhosis and HIV infection. Association with malignancies is not frequent. Lymphoproliferative disorders (Hodgkin's disease, mycosis fungoides, lymphosarcoma, adult T-cell leukemia, multiple mieloma) and solid tumors (lung cancer, colon carcinoma, renal, prostate, head and neck cancer and breast cancer) may be associated with CNV. Whenever possible, treatment is directed at the elimination of the cause. In other cases after adequate laboratory screening local and systemic therapy are recommended.

  15. Cutaneous hypopigmentary disorders – An observational study

    Directory of Open Access Journals (Sweden)

    Kalegowda Deepadarshan

    2016-04-01

    Full Text Available Background: Hypopigmented skin lesions is very common among people of all age groups. There are limited studies in India about evaluation of hypopigmented skin conditions. The aim of my study is to evaluate the different etiologies of cutaneous hypopigmentation. Aim: The present study was undertaken to find the relative incidence of the various disorders causing a hypopigmented lesion in a random sample of 200 cases and to study site, distribution and characteristics of the lesions. Methods: A random sample of 200 patients presenting with one or more hypopigmented lesions to the outpatient department of Dermatology, Venereology and Leprosy in KVG Medical College and Hospital, Sullia from December 2011 to January 2013 was studied. Detailed history including address and occupation with special reference to onset and duration, preceding skin conditions, exposure to chemicals, topical application and family history was taken. Various characteristics of the lesion like site, size, number, distribution, surface and sensation were studied. After this samples were taken for relevant investigations like complete hemogram, biopsy, slit skin smear, KOH mount and assessed for the causes of hypopigmented lesions. Results: In our study, most common cause with cutaneous hypopigmentation was pityriasis versicolor, seen in 52%, followed by post inflammatory hypopigmentation in 32%, pre vitiligo in 6.5%, Hansen’s disease, idiopathic guttate hypomelanosis, nevus anemicus each in 2%, Woronoff’s ring in 1.5% and miscellaneous conditions in 2% of the cases. Commonest age group affected was 21-30 years. Males (49% and females (51% were almost equally affected. Conclusion: The study concludes that various conditions comes under hypopigmentary disorders. More common in young adults. Most common scaly condition was pityriasis versicolor and non scaly condition was pre vitiligo. Proper counseling and ruling out Hansen’s disease is required to alleviate the patient

  16. Unusual Presentation of Cutaneous Leishmaniasis: Ocular Leishmaniasis

    Science.gov (United States)

    Doroodgar, Masoud; Doroodgar, Moein

    2017-01-01

    The leishmaniases are parasitic diseases that are transmitted to humans by infected female sandflies. Cutaneous leishmaniasis (CL) is one of 3 main forms of the disease. CL is the most common form of the disease and is endemic in many urban and rural parts of Iran and usually caused by two species of Leishmania: L. major and L. tropica. We report a case of unusual leishmaniasis with 25 lesions on exposed parts of the body and right eyelid involvement (ocular leishmaniasis). The patient was a 75-year-old male farmer referred to health care center in Aran va Bidgol city. The disease was diagnosed by direct smear, culture, and PCR from the lesions. PCR was positive for Leishmania major. PMID:28210511

  17. Cutaneous manifestations of familial amyloidotic polyneuropathy.

    Science.gov (United States)

    Rocha, N; Velho, G; Horta, M; Martins, A; Massa, A

    2005-09-01

    Familial amyloidotic polyneuropathy is an autosomal dominant amyloidosis, characterized by the systemic deposition of amyloid with a particular involvement of the peripheral nerves. The disease generally manifests as a severe sensory, motor and autonomic neuropathy. Cardiomyopathy, nephropathy, vitreous opacities and carpal tunnel syndrome may occur in a variable association with the neuropathy. Trophic dermatological lesions are frequent in the more advanced stages of the disease. We examined the skin of 142 patients. The cutaneous manifestations more frequently observed were: xerosis (81.6%), seborrheic dermatitis (21.8%), traumatic and burn lesions (19.7%), acne (18.3%), neurotrophic ulcers (14%) and onychomycosis (10.5%). Among the hepatic transplanted patients (31%), seborrheic dermatitis and acne were the most frequent diagnoses.

  18. Cutaneous foetal injuries related to amniocentesis.

    Science.gov (United States)

    Papi, L; Farusi, F; Teti, G; Dini, V; Romanelli, M

    2013-10-01

    Amniocentesis is one of the most important prenatal diagnostic procedures available to assess congenital abnormalities. It is performed worldwide due to its simplicity of execution and lack of risk. The most frequent known accidents in amniocentesis are abortion, oligohydramnios, amniositis and placental abruption, while direct fetal injuries produced by contact with the needle are rarely seen. The injuries produced are extremely variable in severity, but the most frequent is skin wounds, which usually heal as small, round depressed scars. The cases we describe concern the occurrence of iatrogenic cutaneous wound lesions to a fetus during amniocentesis. The medical-legal analysis of the cases required dermatological expertise in order to exclude a different pathogenesis for the skin injuries to the child and were assigned by the court, in order to assess the administrative compensation due to the parents of the child as a result of medical malpractice.

  19. Mycobacterium fortuitum cutaneous infection from amateur tattoo.

    Science.gov (United States)

    Suvanasuthi, Saroj; Wongpraparut, Chanisada; Pattanaprichakul, Penvadee; Bunyaratavej, Sumanas

    2012-06-01

    A case of cutaneous Mycobacterium fortuitum infection after receiving an amateur tattoo is reported. A few days after tattooing, an otherwise healthy 25-year-old Thai male presented with multiple discrete erythematous papules confined to the tattoo area. He was initially treated with topical steroid and oral antihistamine without improvement. Skin biopsy was carried out, and the histopathology showed mixed cell granuloma with a foreign body reaction (tattoo color pigments). The acid-fast bacilli stain was positive. The tissue culture grew M. fortuitum two weeks later. He was treated with clarithromycin 1,000 mg/day and ciprofloxacin 1,000 mg/day for 10 months with complete response. From the clinical aspect, tattoo-associated rapidly growing mycobacterium infection might be difficult to differentiate from the pigment-based skin reactions. Skin biopsy for histopathology and tissue culture for Mycobacterium probably will be needed in arriving at the diagnosis.

  20. Les paradoxes de la matière

    CERN Document Server

    2013-01-01

    Si nous devons la multitude d’appareils numériques actuels à l’électronique, celle-ci atteint ses limites. Comment les dépasser ? En explorant les propriétés spectaculaires de la matière ! Et les candidats au remplacement de l’électronique sont nombreux : oxytronique, spintronique, plasmonique, magnonique, graphène... Nous réservant aussi bien d’autres surprises - tels les capes d’invisibilité, les plastiques conducteurs, les polymères autocicatrisants, les protections antisismiques, etc - les études sur la matière n’ont pas fini de nous étonner.

  1. Blog and Podcast Watch: Cutaneous Emergencies.

    Science.gov (United States)

    Grock, Andrew; Morley, Eric J; Roppolo, Lynn; Khadpe, Jay; Ankel, Felix; Lin, Michelle

    2017-02-01

    The WestJEM Blog and Podcast Watch presents high quality open-access educational blogs and podcasts in emergency medicine (EM) based on the ongoing Academic Life in Emergency Medicine (ALiEM) Approved Instructional Resources (AIR) and AIR-Professional series. Both series critically appraise resources using an objective scoring rubric. This installment of the Blog and Podcast Watch highlights the topic of cutaneous emergencies from the AIR series. The AIR series is a continuously building curriculum that follows the Council of Emergency Medicine Residency Directors (CORD) annual testing schedule. For each module, relevant content is collected from the top 50 most accessed sites per the Social Media Index published within the previous 12 months and scored by eight board members using five equally weighted measurement outcomes: Best Evidence in Emergency Medicine (BEEM) score, accuracy, educational utility, evidence based, and references. Resources scoring ≥30 out of 35 available points receive an AIR label. Resources scoring 27-29 receive an "honorable mention" label, if the editorial board agrees that the post is accurate and educationally valuable. A total of 35 blog posts and podcasts were evaluated. None scored ≥30 points necessary for the AIR label, although four honorable mention posts were identified. Key educational pearls from these honorable mention posts are summarized. This Blog and Podcast Watch series is based on the AIR and AIR-Pro series, which attempts to identify high quality educational content on open-access blogs and podcasts. This series provides an expert-based, post-publication curation of educational social media content for EM clinicians with this installment focusing on cutaneous emergencies.

  2. Blog and Podcast Watch: Cutaneous Emergencies

    Directory of Open Access Journals (Sweden)

    Andrew Grock

    2017-02-01

    Full Text Available The WestJEM Blog and Podcast Watch presents high quality open-access educational blogs and podcasts in emergency medicine (EM based on the ongoing Academic Life in Emergency Medicine (ALiEM Approved Instructional Resources (AIR and AIR-Professional series. Both series critically appraise resources using an objective scoring rubric. This installment of the Blog and Podcast Watch highlights the topic of cutaneous emergencies from the AIR series.    The AIR series is a continuously building curriculum that follows the Council of Emergency Medicine Residency Directors (CORD annual testing schedule. For each module, relevant content is collected from the top 50 most accessed sites per the Social Media Index published within the previous 12 months and scored by eight board members using five equally weighted measurement outcomes: Best Evidence in Emergency Medicine (BEEM score, accuracy, educational utility, evidence based, and references. Resources scoring ≥30 out of 35 available points receive an AIR label. Resources scoring 27-29 receive an “honorable mention” label, if the editorial board agrees that the post is accurate and educationally valuable. A total of 35 blog posts and podcasts were evaluated. None scored ≥30 points necessary for the AIR label, although four honorable mention posts were identified. Key educational pearls from these honorable mention posts are summarized. This Blog and Podcast Watch series is based on the AIR and AIR-Pro series, which attempts to identify high quality educational content on open-access blogs and podcasts. This series provides an expertbased, post-publication curation of educational social media content for EM clinicians with this installment focusing on cutaneous emergencies. [West J Emerg Med. 2017;18(2288-292.

  3. A rare cause of cutanous vasculitis: Anastrosole

    Directory of Open Access Journals (Sweden)

    Didem Arslan Tas

    2014-04-01

    Full Text Available Breast cancer is the most frequently diagnosed type of cancer and the foremost reason of the death of women from cancer. Hormone receptor positive breast cancer is the most frequent type of breast cancer. Anastrosole is one of the aromatase inhibitors which is indicated for early stage of hormone receptor positive breast cancer of postmenopausal women. A 67-year-old woman was refered to Rheumatology Department from Medical Oncology Department for skin rashes which have started 3 months ago. In her medical history, she was diagnosed as infiltrative ductal carcinoma grade-2 in the right breast. She had a modified radical mastectomy operation for the right breast and subsequently, anastrosole was started as her hormone receptor was found positive in histopathological examination. The drug was stopped after 5 years by her oncologist however she went on using the drug on her own demand. Three months before her referral, non-itchy, painless reddish rash was started on legs and arms. After careful physical and laboratory examination and histopathologic alevaluation, she was diagnosed as middle-vessel necrotising vasculitis. Anastrosole was stopped. Steroid and azathyoprine were started. On the fifth month of therapy, all skin lesions were resolved with postinflammatory hyperpigmentation. No additional problem was met. This case report is suggesting that, anastrosole which is a frequently preferred agent in recentyears, could also cause leucocytoclastic vasculits. Very rare cases with cutanous vasculitis were previously presented. This case report suggests that, during the management of patients under anastrosole therapy, cutanous vasculitis should be monitored carefully. [Cukurova Med J 2014; 39(2.000: 369-372

  4. Management of cutaneous Merkel cell carcinoma.

    Science.gov (United States)

    Mendenhall, William M; Morris, Christopher G; Kirwan, Jessica M; Amdur, Robert J; Shaw, Christiana; Dziegielewski, Peter T

    2017-07-15

    To report the outcomes of patients with previously untreated cutaneous Merkel cell carcinoma (MCC) managed with curative intent. Between December 1984 and August 2015, 59 patients with previously untreated cutaneous MCC were managed with curative intent with surgery and adjuvant radiotherapy (54 patients) or radiotherapy alone (5 patients) at the University of Florida. Primary sites included head and neck (45 patients), extremities (11 patients) and trunk (3 patients). Adjuvant chemotherapy was employed in 14 patients. Patients were staged according to the AJCC staging system: stage I, 25 patients; stage IIA, 7 patients; and, stage III, 27 patients. No patients had distant metastases. Median follow-up for all patients was 3.2 years (range, 0.3-20.9 years). Median follow-up for survivors was 6.7 years (range, 1.6-20.9 years). The 5-year outcomes were as follows: local control, 91%; regional control, 79%; local-regional control, 77%; disease metastasis-free survival, 60%; cause-specific survival, 53%; and overall survival, 39%. The 5-year outcomes for patients with stage I-IIA versus stage-III disease were the following: local-regional control, 90% versus 57% (p = .0115); distant metastasis-free survival, 78% versus 36% (p = .0002); cause-specific survival, 68% versus 35% (p = .0050); and overall survival, 48% versus 27% (p = .0377). Local-regional recurrences occurred in 12 patients; no patients were successfully salvaged. Severe late complications were observed in four patients. Although radiotherapy alone or combined with surgery results in a relatively high likelihood of local-regional control, the majority of recurrences are distant and approximately half of patients are cured. Patients with regional disease at diagnosis have significantly worse outcomes.

  5. The risk of cutaneous melanoma in melanocytic nevi Risco de melanoma cutâneo nos nevos melanocíticos

    Directory of Open Access Journals (Sweden)

    Nurimar Conceição Fernandes

    2013-04-01

    Full Text Available The data on melanoma associaed with melanocytic nevus are controversial. A longitudinal prospective study of 107 cases of cutaneous melanoma revealed that 9 (8.4% cases were presumed to be linked to a precursor lesion, but only in 1 (0.9% out of these cases the histopathological examination showed an associated melanocytic nevus. The vague information of a preexisting lesion of cutaneous melanoma is not sufficient to consider it a tumour precursor and it requires histopathological evidence to confirm the diagnosis.Os dados sobre risco de melanoma cutâneo nos nevos melanocíticos são ainda controversos. O estudo longitudinal prospectivo de 107 casos de melanoma cutâneo revelou que em 9/107 casos (8,4% houve presunção de lesão precursora, porém em 1/107 caso (0,9% houve comprovação histopatológica para nevo melanocítico. A informação vaga de presença de lesão precursora do melanoma cutâneo torna vulnerável sua vinculação com o tumor e implica em comprovação histopatológica.

  6. Les Robertson, CERN's LCG project manager

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    "The LCG will provide a vital test-bed for the new Grid computing technologies that are set to revolutionise the way scientists use the world's computing resources in areas ranging from fundamental research to medical diagnosis," said Les Robertson, CERN's LCG project manager. The Grid is a new method of sharing processing power between computers in centres around the world.

  7. Maintenance sur les infrastructures de surface

    CERN Document Server

    Chevret, P

    2000-01-01

    L'objet de ce document est de dresser le bilan de l'activité du Groupe Technical Facilities Management dans le domaine de la maintenance. Ce bilan couvre les activités techniques du génie civil, du chauffage-climatisation et de l'électricité, s'appliquant dans une large majorité au seul secteur tertiaire, tant sur le plan préventif que correctif. Les principaux paramètres indicateurs de l'activité sont situés dans leur évolution au cours des dernières années. Les auteurs abordent également les principaux projets complémentaires de maintenance, qui sont conduits pour maintenir l'état du patrimoine en dépit des restrictions budgétaires, faire face aux problèmes d'obsolescence, de défaillances récurrentes sur certains matériels, et satisfaire aux normes de sécurité. L'incidence positive de ces actions sur le nombre d'interventions de maintenance corrective est également montrée. Enfin, des perspectives de progrès sont dégagées, visant à une gestion davantage prévisionnelle de la ma...

  8. LES TUMEURS MALIGNES DE LA PAROTIDE

    African Journals Online (AJOL)

    18 juin 2007 ... cancers parotidiens opérés dans notre service entre 1994 et 2006, incluant les ... dans 7 cas, un trismus dans un cas, des otalgies dans 2 cas. .... gnant salivary gland tumors by fast neutron radiotherapy. Int J Radiat ... 18-Fordice J, El-naggar; Adenoid cystic carcinoma of the head and neck : pre- dictors of ...

  9. Les communes bretonnes sur le Web

    Directory of Open Access Journals (Sweden)

    Hélène Martin-Brelot

    2015-10-01

    Full Text Available Dans un contexte de montée en puissance des usages d’Internet d’une part, et d’incertitude territoriale d’autre part, l’hypothèse principale de cette étude est que le Web modifie la portée spatiale des organisations publiques, en offrant notamment un nouveau cadre pour exprimer des relations territoriales variées. L’exploration des hyperliens de près de 400 sites de communes du Morbihan et du Finistère permet tout d’abord d’en évaluer la richesse de contenu (images, vidéos… et d’ouverture vers l’extérieur (liens externes, Facebook, etc.. Si les sites les plus fournis et ouverts tendent à appartenir aux communes les plus peuplées, l’examen des relations entre ces sites montre que de très petites communes peuvent occuper des positions centrales dans l’espace virtuel. Des différences de configurations entre les graphes de chaque département sont également identifiées.

  10. Les oniriques Fleurs bleues de Raymond Queneau

    Directory of Open Access Journals (Sweden)

    Primož Vitez

    2012-12-01

    Full Text Available Dans Les fleurs bleues (1965 de Raymond Queneau, le narrateur fait couler deux histoires parallèles qui se terminent dans lʼunité du présent énonciatif.Lʼeffet contrastant de ce double récit, habité dʼun côté par le DucdʼAuge et de lʼautre par un certain Cidrolin, deux facettes dʼun seul personnage, se fonde sur un principe onirique, déclenché au moment quand le Duc dʼAuge sʼendort; dans son rêve se déploie lʼhistoire de Cidrolin qui finitpar sʼendormir à son tour - et voilà le lecteur replongé dans les aventures du Duc. Ce que lʼauteur développe par ses astuces narratives, cʼest la pluralité du réel, ce sont les parallélismes invisibles, cʼest la promesse dʼune perspective existentielle, cʼest la fécondité de lʼironie. À travers la variation de ce qui apparamment est ordinaire, Queneau démontre une dimension extraordinaire de lʼinvention littéraire.

  11. Où sont passés les trous noirs primordiaux?

    CERN Multimedia

    Barrau, A

    2003-01-01

    L'existence de minuscules trous noirs est théoriquement possible mais, toutes les expériences se sont soldées par un échec. Les physiciens son toujours optimistes: puisqu'ils les ont pensés, pourquoi n'existeraient-ils pas?" (6 pages).

  12. LES based POD analysis of Jet in Cross Flow

    DEFF Research Database (Denmark)

    Cavar, Dalibor; Meyer, Knud Erik; Jakirlic, S.

    2010-01-01

    The paper presents results of a POD investigation of the LES based numerical simulation of the jet-in-crossflow (JICF) flowfield. LES results are firstly compared to the pointwise LDA measurements. 2D POD analysis is then used as a comparison basis for PIV measurements and LES, and finally 3D POD...

  13. Les nouveaux espaces de l'industrie en France

    Directory of Open Access Journals (Sweden)

    Roger BRUNET

    1986-03-01

    Full Text Available Des cartes à un niveau d'analyse nouveau, et la représentation modélisée des structures et tendances fondamentales de l'espace industriel français, permettent de discerner les situations «porteuses» pour l'avenir des entreprises, et les conditions dans lesquelles se font les changements.

  14. Les livres pairs d’Alfred Jarry

    Directory of Open Access Journals (Sweden)

    Julien Schuh

    2008-10-01

    Full Text Available Dans les Gestes et opinions du Dr Faustroll, pataphysicien, Alfred Jarry décrit une bibliothèque idéale, composée de 27 ouvrages qu’il nomme mystérieusement des « livres pairs ». Dans cette liste, on trouve aussi bien des œuvres canoniques du symbolisme (Mallarmé, Verlaine, Poe traduit par Baudelaire, des titres des amis de Jarry et des piliers des revues de l’époque (Rachilde, Gustave Kahn, Léon Bloy, que des ouvrages que l’on assimile davantage aux lectures enfantines (un conte de Marceline Desbordes-Valmore, les Mille et une Nuits, le théâtre de Florian ou des textes hors-catégorie (l’œuvre de Rabelais, l’évangile de Luc, les Chants de Maldoror. Beaucoup de critiques se sont interrogés sur la notion de « parité », sur l’égalité supposée entre ces ouvrages n’appartenant pas aux mêmes catégories littéraires. Mais l’intérêt de cette liste n’est pas de fournir un classement, ou d’affirmer l’équivalence de toutes les formes textuelles, comme on l’analyse souvent, en faisant de Jarry un chantre du nihilisme qui chercherait à pervertir les hiérarchies littéraires pour montrer la vacuité du sens. Au contraire, en faisant débuter le Faustroll par une liste d’ouvrages, Jarry met en place les conditions de réception de son texte, dans une posture très littéraire. L’espace délimité par la liste des auteurs pairs fonctionne comme un portrait spirituel de Jarry-littérateur, et livre le contexte selon lequel son discours doit être reçu. La bibliothèque du Dr Faustroll fixe les références que le lecteur pourra voir convoquer dans le texte, et circonscrit l’espace littéraire dans lequel peut fonctionner cet ouvrage.

  15. Des broussailles dans les prairies alpines

    Directory of Open Access Journals (Sweden)

    Olivier Camacho

    2009-03-01

    Full Text Available Landscape closing due to the decline in agricultural activity is considered to be a major problem in the Alps. Abondance Valley provides a good example of this phenomenon and is also representative of a paradox commonly found in the Northern French Alps: the mountainsides and alpine pastures are still used, whereas they are becoming increasingly afforested. Environmental conditions play a major role in the localisation of agricultural land uses, but they are not sufficient to explain why pastures still in use are being invaded by shrub. Even if cutting makes it possible to effectively control the encroachment by woody species, this is not true for uncut pastures where grazing is not able to keep up with grass production. This situation is repeated every year and is the likely cause of the colonisation by woody species. To ensure their forage system and to simplify their work, farmers tend to establish grazing units that are oversized in relation to the needs of their animals. They implement compensatory practices that consist of mechanical maintenance as a complement to grazing to limit the dynamics of woody species. These labour-intensive practices are not used on all of the pastures. The analysis of farmers’ practices by agronomists is therefore a useful complement to studies of physical and socio-economic environments, at the level of the grazed field as well as at that of the valley as a whole.La dégradation des paysages par suite du recul de l’activité agricole est considérée comme un enjeu majeur dans les Alpes. La vallée d’Abondance illustre bien ce phénomène de fermeture de l’espace mais elle est en outre représentative d’un paradoxe assez répandu dans les Alpes du nord françaises : les versants et les alpages sont encore exploités et pourtant ils se boisent progressivement. Les conditions de milieux jouent un rôle majeur sur la localisation des usages agricoles de l'espace, mais elles ne peuvent pas suffire pour

  16. Faut-il brûler les dictionnaires ? Ou comment les ressources numériques ont révolutionné les recherches en morphologie

    Directory of Open Access Journals (Sweden)

    Namer Fiammetta

    2012-07-01

    Full Text Available Pour mener leurs études, les morphologues, et, singulièrement parmi eux, ceux qui traitent du lexique construit, sont pris entre deux tensions : utiliser les données issues des dictionnaires, réputées fiables parce que passées au travers du crible de l’institutionnalisation, ou se fonder sur des données authentiques, produites dans des situations écologiques. Bien qu’inspirant encore de la défiance, le Web devient alors la ressource par excellence. Les ressources numérisées telles que les archives de journaux ou les bases de données de textes littéraires constituent un moyen terme entre ces deux pratiques : elles permettent d’effectuer des recherches basées sur l’usage, tout en offrant la garantie d’une certaine tenue linguistique de la part des scripteurs, la plupart du temps identifiables. Dans cette communication, nous nous demanderons si les dictionnaires méritent la confiance que continuent de leur octroyer les morphologues ou, plus exactement, si une morphologie qui puise ses données dans les seuls dictionnaires peut encore avoir cours au 21e siècle. Pour engager cette discussion, nous commencerons par poser la question de l’existence, pour un lexème construit. Nous exposerons ensuite ce que constitue une morphologie basée sur l’usage, puis donnerons un aperçu des types de recherches que permettent de réaliser les ressources non dictionnairiques. La conclusion sera que, si les dictionnaires continuent d'avoir droit de cité dans la panoplie du morphologue, une morphologie uniquement basée sur les données qu'ils contiennent passerait outre de nombreuses recherches, plus fructueuses les unes que les autres.

  17. Notice sur les Lépidoptères des îles Natuna

    NARCIS (Netherlands)

    Snellen, P.C.T.

    1895-01-01

    Mr. Ritsema, Conservateur de la collection d’Insectes du Musée de Leyde, ayant reçu quelques Lépidoptères que Mr. A. L. van Hasselt, Résident de Riouw et de ses dépendances, avait recueillis aux îles Natuna, me pria d’en dresser la liste, parce que jusqu’ici rien n’avait été publié sur les insectes

  18. MicroRNA and gene signature of severe cutaneous drug ...

    African Journals Online (AJOL)

    MiR-GNLY loop interactions in hypersensitivity reactions may function ... Keywords: Severe cutaneous adverse drug reactions (SCAR) Steven-Johnson Syndrome, Toxic epidermal necrolysis ..... d), which permit unrestricted use, distribution,.

  19. Cutaneous and systemic hypersensitivity reactions to metallic implants

    DEFF Research Database (Denmark)

    Basko-Plluska, Juliana L; Thyssen, Jacob P; Schalock, Peter C

    2011-01-01

    ) following the insertion of intravascular stents, dental implants, cardiac pacemakers, or implanted gynecologic devices. Despite repeated attempts by researchers and clinicians to further understand this difficult area of medicine, the association between metal sensitivity and cutaneous allergic reactions...

  20. Primary cutaneous nocardiosis: A case study and review

    Directory of Open Access Journals (Sweden)

    Inamadar A

    2003-11-01

    Full Text Available BACKGROUND: Primary cutaneous nocardiosis is an uncommon entity. It usually occurs among immunocompetent but occupationally predisposed individuals. AIM: To study clinical profile of patients with primary cutaneous nocardiosis in a tertiary care hospital and to review the literature. METHODS: The records of 10 cases of primary cutaneous nocardiosis were analyzed for clinical pattern, site of involvement with cultural study and response to treatment. RESULTS: All the patients were agricultural workers (nine male except one housewife. The commonest clinical type was mycetoma. Unusual sites like the scalp and back were involved in two cases. Culture was positive in six cases with N. brasiliensis being commonest organism. N. nova which was previously unreported cause of lymphocutaneous nocardiosis, was noted in one patient, who had associated HIV infection. All the patients responded to cotrimaxazole. CONCLUSION: Mycetoma is the commonest form of primary cutaneous nocardiosis and responds well to cotrimoxazole.

  1. Taxonomy and epidemiology Mucor irregularis, agent of chronic cutaneous mucormycosis

    NARCIS (Netherlands)

    Lu, X.L.; Najafzadeh, M.J.; Dolatabadi, S.; Ran, Y.P.; Gerrits van den Ende, A.H.G.; Shen, Y.N.; Li, C.Y.; Xi, L.Y.; Hao, F.; Zhang, Q.Q.; Li, R.Y.; Hu, Z.M.; Lu, G.; Wang, J.J.; Drogari-Apiranthitou, M.; Klaassen, C.; Meis, J.F.; Hagen, F.; Liu, W.D.; de Hoog, G.S.

    2013-01-01

    Mucormycosis usually presents as a progressive infection with significant angio-invasion. Mucormycosis due to Mucor irregularis (formerly Rhizomucor variabilis var. variabilis), however, is exceptional in causing chronic cutaneous infection in immunocompetent humans, ultimately leading to severe mor

  2. Cutaneous angiosarcoma arising in a mastectomy scar after therapeutic irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Hamels, J. (Institute of Morphological Pathology, Loverval); Blondiau, P. (City Hospital, B-Jumet); Mirgaux, M. (St Joseph, B-Gilly)

    1981-01-01

    A cutaneous angiosarcoma developed in a mastectomy scar four years after post operative irradiation. Clinical and histological data are presented. The authors believe that radiotherapy was determinant in the genesis of this rare type of tumour.

  3. Cutaneous Manifestations of Primary Immunodeficiency Diseases in Children

    Directory of Open Access Journals (Sweden)

    Athar Moin

    2006-09-01

    The purpose of this study was to determine the frequency and nature of cutaneous alterations associated with PIDs. This article is a cross-sectional study at the department of allergy and clinical immunology of children’s medical center conducted between December 5, 2001 and April 20, 2002. The subjects included pediatric patients with a diagnosis of PID and dermatological diagnoses were made by a dermatologist. Two hundred and ten patients were studied They consisted of 68 cases of humoral deficiency, 22 cases of cellular and combined deficiencies, 57 cases of phagocytic defects and 63 cases of other PIDs. In 67 cases (31.8% the cutaneous alterations preceded and were the basis for clinical immunological diagnosis. Overall cutaneous alterations were infections in 99 cases and eczematous dermatitis in 27 cases. Our findings support the results of other studies that most PIDs have cutaneous features which being their typical aspects are highly suggestive for the diagnosis of PIDs.

  4. [Tungiasis and cutaneous larva migrans: unpleasant travel souvenirs].

    Science.gov (United States)

    Feldmeier, Hermann

    2009-12-01

    Tungiasis (sand flea disease) and cutaneous larva migrans (creeping eruption) are parasitic skin diseases in which the infectious agents only temporarily invade human skin. The parasites die in situ and eventually are eliminated by tissue repair mechanisms. Both diseases are zoonoses. Humans only accidentally become a host for animal hookworm larvae (resulting in cutaneous larva migrans), but get infected with Tunga penetrans as frequent as domestic animals. In travelers to tropical and subtropical regions tungiasis and cutaneous larva migrans are the most common imported skin diseases. The diagnosis is made clinically. In tungiasis the clinical manifestations depend on the stage of the disease. Intense local inflammation and bacterial superinfection are common. Cutaneous larva migrans is treated orally with ivermectin or albendazole. A repellent based on coconut oil effectively prevents penetration of sand fleas.

  5. Cutaneous leishmaniasis in germfree, gnotobiotic, and conventional mice

    Directory of Open Access Journals (Sweden)

    Enio Cardillo Vieira

    1987-12-01

    Full Text Available Cutaneous leishmaniasis was much more severe in conventional than in gnotobiotic mice as revealed by macro and microscopic examination. An inoculum of Leishmania mexicana amazonensis was used.

  6. Homozygous Hypercholesterolaemia With Cutaneous And Tendinous Xanthoma In A Child

    Directory of Open Access Journals (Sweden)

    Lahiri Bhabesh Chandra

    2000-01-01

    Full Text Available A seven year old male child, born of a consanguineous marriage is reported for the rare occurrence of severe hypercholesterolaemia with cutaneous and tendinous xanthoma, mental retardation and eosinophilia in his childhood.

  7. Continent cutaneous diversion for bladder exstrophy in adults

    Directory of Open Access Journals (Sweden)

    J.E. Mensah

    2013-06-01

    Conclusion: Bladder neck closure in conjunction with continent cutaneous diversion is a reliable and safe method for achieving continence in adults presenting with bladder exstrophy. Total continence can be achieved without resorting to multiple complex and expensive surgeries.

  8. Note sur les fondements des postcolonial studies

    Directory of Open Access Journals (Sweden)

    Béatrice Collignon

    2008-03-01

    Full Text Available Longtemps absent dans les sciences sociales françaises, le terme "postcolonial" apparaît de plus en plus fréquemment dans les publications et programmes de rencontres, sous l'impulsion des débats autour de l'héritage de la colonisation et des "indigènes de la République". Dans ce contexte, cette note présente les principaux traits qui fondent des postcolonial studies telles qu'elles se sont développées dans le monde anglo-saxon depuis une vingtaine d'années. Cette mise au point, à l'usage des géographes entre autres, vise à clarifier les échanges en montrant le décalage entre le post-colonial français et les postcolonial studies.Long ignored by French social sciences, the term "postcolonial" has recently become popular in academic literature and meetings, in relation to the political debate about colonial legacy and 2nd and 3rd immigrants generations (the so-called "indigènes de la République". Yet, although the term is the same ("postcolonial", the meaning it is usually given in France by those who qualify their work as such is quite different from the one it has in the anglo world. In this context, this note aims at clarifying the situation for French geographers and others by presenting briefly some of the main aspects of postcolonial theory.

  9. Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis

    OpenAIRE

    Maria Fátima Horta; Bárbara Pinheiro Mendes; Eric Henrique Roma; Fátima Soares Motta Noronha; Juan Pereira Macêdo; Luciana Souza Oliveira; Myrian Morato Duarte; Leda Quercia Vieira

    2012-01-01

    Cutaneous leishmaniasis affects millions of people around the world. Several species of Leishmania infect mouse strains, and murine models closely reproduce the cutaneous lesions caused by the parasite in humans. Mouse models have enabled studies on the pathogenesis and effector mechanisms of host resistance to infection. Here, we review the role of nitric oxide (NO), reactive oxygen species (ROS), and peroxynitrite (ONOO−) in the control of parasites by macrophages, which are both the host c...

  10. Renaissance of Low-Dose Radiotherapy Concepts for Cutaneous Lymphomas.

    Science.gov (United States)

    Dabaja, Bouthaina

    2017-01-01

    Primary cutaneous B- and T-cell lymphomas are rare types of non-Hodgkin's lymphoma with a unique presentation. This can make it challenging for clinicians to manage these cases, and quite often the management mirrors that of other commonly seen lymphomas. This document summarizes how to manage primary cutaneous lymphoma with specific focus on the role of ultralow-dose radiation. © 2017 S. Karger GmbH, Freiburg.

  11. Cutaneous responses to vaccinia in individuals with previous smallpox vaccination.

    Science.gov (United States)

    Simpson, Eric L; Hercher, Michelle; Hammarlund, Erika K; Lewis, Matthew W; Slifka, Mark K; Hanifin, Jon M

    2007-09-01

    The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.

  12. Cutaneous disseminated sporotrichosis: Clinical experience of 24 cases.

    Science.gov (United States)

    Bonifaz, Alexandro; Tirado-Sánchez, Andrés; Paredes-Solís, Vanesa; Cepeda-Valdés, Rodrigo; González, Gloria María; Treviño-Rangel, Rogelio de J; Fierro-Arias, Leonel

    2017-08-22

    Sporotrichosis is a subcutaneous mycosis, caused by complex Sporothrix schenckii, It is the most common implantation mycoses in worldwide. It is a polymorphic disease, cutaneous-lymphatic is the most frequent (75-90%).(1-3) We report our 25 years' experience (1990-2015) in cutaneous disseminated sporotrichosis (CDS). We conducted, an open, retrospective and observational study. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  13. A study on the cutaneous manifestations of diabetes mellitus

    OpenAIRE

    Neerja Puri

    2012-01-01

    The cutaneous manifestations of diabetes mellitus are varied. We conducted a study of fifty patients having diabetes mellitus coming from the department of dermatology and medicine. The commonest cutaneous feature of diabetes were pyodermas seen in 40% patients, dermatophytosis seen in 36% patients, pruritis diabetic thick skin seen in 20 % patients, diabetic dermopathy seen in 16% patients, diabetic bulla and rubeosis seen in 8% patients each and meralgia paraesthetica and diabetic foot seen...

  14. Cutaneous metastasis of colon cancer: case report and literature review.

    Science.gov (United States)

    Sheets, Nicholas; Powers, Jeremy; Richmond, Bryan

    2014-01-01

    Cutaneous metastases arising from an internal malignancy are a rare phenomenon, occurring in 0.001% of all skin biopsies performed. Of these, 6.5% originate from the a primary colon cancer. Colon cancer, when metastatic to the skin, typically appears as a painless flesh-colored nodule or as a mass with occasional ulceration. We report a case of a large cutaneous metastasis to the suprascapular region as the initial presenting symptom of an underlying colon cancer.

  15. Cutaneous Mycobacterium abscessus Infection Associated with Mesotherapy Injection

    Directory of Open Access Journals (Sweden)

    Pranee Wongkitisophon

    2011-02-01

    Full Text Available Non-tuberculous mycobacterial skin infections have an increasing incidence. In immunocompetent patients, they usually follow local trauma. We present a case of cutaneous Mycobacterium abscessus infection following mesotherapy. The lesions were successfully treated with a combination of clarithromycin, ciprofloxacin, and doxycycline. Atypical mycobacterial infection should be suspected in patients who develop late-onset skin and soft tissue infection after cutaneous injury, injection, and surgical intervention, particularly if they do not respond to conventional antibiotic treatment.

  16. The Response of Rats to Cutaneous Dosing with Trichothecene Mycotoxins,

    Science.gov (United States)

    1983-10-01

    trichothecene absorption by human skin is unknown. We have found no synergism between T-2 and DAS, but to test all aspects of synergism and of solvent...AD Al39 548 THE RESPONSE OF RATS TO CUTANEOUS DOSING WITH TRICHOTHECENE MYCOTOXINSIU) MATERIALS RESEARCH LABS ASCOT VALE IAUSTRALIA) H 0 CRONE OCT 83...902 de THE RESPONSE OF RATS TO CUTANEOUS DOSING WITH TRICHOTHECENE MYCOTOXINS 4 H.D. Crone TDTI Approved for Public Rlelease 2 004 Cmmealth of

  17. Severe cutaneous reaction induced by Hirudoid: a rare case report

    OpenAIRE

    Wei He; Zhumei Shao; Cuiping Wang; Yanan Zhang; Rong Yan

    2015-01-01

    Objective: To explore the clinical characteristics, diagnosis and prognosis of local severe cutaneous reactions as result of the treatment with Hirudoid. Methods: One case of severe cutaneous reactions as result of the treatment with Hirudoid was reported and the relevant literatures were reviewed. Results: The site of puncture of left arm occurred non-leakage phlebitis with local pain after chemotherapy. The patient was applied the Hirudoid to the affected areas 2 times daily. After 2 days, ...

  18. Remarques sur les stratifications sociales et les solidarités chez les Musulmans du Sindh colonial

    Directory of Open Access Journals (Sweden)

    Michel Boivin

    2012-01-01

    Full Text Available En 1843, les Britanniques conquéraient le Sindh pour consolider leur frontière occidentale face aux visées des Russes, mais aussi pour contrôler le commerce de la vallée de l’Indus qui débouchait sur la mer d’Oman et l’océan indien. Comme dans le reste de l’empire des Indes, les officiers eurent tôt fait de s’intéresser aux populations de cette province excentrée, qui constituait une frontière entre les territoires à majorité hindoue et le continuum musulman.Ils rédigèrent des rapports qui décrivaient les populations du Sindh et leurs activités, les comparant à l’organisation socio-économique des autres populations de l’empire, et essayant simultanément de les situer par rapport au schème idéologique de l’hindouisme. Ces rapports souvent minutieux, qui témoignaient d’une connaissance approfondie de ces populations, fournissent encore aujourd’hui la majeure partie de la documentation sur la question.Cette contribution étudie le lien entre la hiérarchisation des populations musulmanes et le renouvellement des solidarités dans la période coloniale, soit à peu près sur un siècle. Dans un premier temps, elle examine dans quelle mesure l’activité économique ou le métier déterminait le statut et le rang dans la société musulmane sindhîe. Puis elle aborde la question des solidarités du point de vue de la hiérarchisation des groupes. Elle tente alors de répondre à un double questionnement : quelle forme de solidarité correspondait à quel groupe, et au sein de quels groupes se produisit un renouvellement des solidarités.

  19. Castelain Meunier Christine, Les métamorphoses du masculin

    Directory of Open Access Journals (Sweden)

    Alain Touraine

    2011-02-01

    Full Text Available Ce qui est le plus nouveau dans un livre sur les hommes est le simple fait de nommer les hommes comme une catégorie particulière, ce qu’on faisait et qu’on fait encore plus facilement pour les femmes. Et pour des raisons qui ne se réduisent pas à la tentation de considérer les femmes comme une “minorité”. Nommer les hommes peut avoir bien des sens différents et c’est pour lever nos incertitudes que nous lisons ce nouveau livre de Christine Castelain Meunier. Plusieurs livres et de nombreuses ...

  20. Le contentieux camerounais devant les instances sportives internationales

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    Dikoume François Claude

    2016-01-01

    Les acteurs du sport depuis lors, utilisent donc les voies de recours au niveau international soit vers les fédérations sportives internationales ou encore et surtout vers le TAS qui s'occupe des litiges de toutes les disciplines sportives. Il est question ici de faire un inventaire casuistique descriptif non exhaustif des requêtes contentieuses camerounaises portées devant les diverses instances sportives internationales ; ceci permettra de questionner l'esprit processuel et la qualité technique de leurs réclamations juridiques en matière sportive.

  1. Les écueils du double jeu

    Directory of Open Access Journals (Sweden)

    Séverin Muller

    2007-06-01

    Full Text Available À partir d’une expérience d’observation participante qui a consisté à travailler comme ouvrier puis à intégrer les bureaux de la direction dans un abattoir industriel, l’auteur étudie les effets cognitifs de la transgression d’un ordre établi dans l’entreprise : les ouvriers avec les ouvriers et les cadres avec les cadres. Les situations décrites de rupture avec les usages du milieu permettent de réfléchir aux façons d’être identifié selon les circonstances, aux formes d’instrumentalisation du chercheur sur son terrain, aux manières dont la confiance s’acquiert se maintient ou se perd dans un environnement conflictuel (selon quels critères propres à chaque groupe sommes nous acceptés, cooptés ou exclus ?. Finalement, la démarche transversale et le jeu transgressif qu’elle suggère participent à l’apprentissage des systèmes de référence non partagés au sein d’une même organisation.Starting from an experiment of participating observation which consisted in working as worker then to integrate the offices of the direction in an industrial slaughterhouse, the author studies the cognitive effects of the transgression of an order established in the company: workers with the workers and managers with the managers. The described situations of rupture with the uses of the social sphere make it possible to think of the ways of being identified according to circumstances, the shapes of « instrumentalisation » of the researcher on his field, with the ways in which confidence is acquired, is maintained or lost in a conflict environment (according to which specific criteria to each group are us accepted, co-opted or excluded?. Finally, the transverse way and the transgressive play that it suggests take part in the training of the systems of reference not shared in the same organization.A partir de un experimento de observación participante que consistió en trabajar como obrero antes de integrar las

  2. Specific cutaneous manifestations of internal malignancy.

    Science.gov (United States)

    Kaplan, R P

    1986-01-01

    In summary, carcinoma is the most frequent cancer that metastasizes to the skin; lung cancer in men and breast cancer in women. Clinically distinctive patterns of cutaneous metastasis of epithelial origin include alopecia neoplastica, pulsatile nodules, Sister Mary Joseph's nodules, morpheaform, and cellulitis-like lesions. Biopsying these lesions reveals adenocarcinoma, squamous cell carcinoma, or anaplastic carcinoma. The type of histologic pattern seen can be a clue to the organ of origin giving rise to the cutaneous metastasis. Skin that is damaged allows for circulating malignant cells, often of epithelial or leukemic origin, to lodge and proliferate locally (inflammatory oncotaxis). The commonest form of leukemia to affect the skin of elderly males is chronic lymphocytic leukemia. However, when leukemia involves the mucous membranes, acute myeloid leukemia (acute monocytic and acute myelomonocytic leukemia) is the most likely diagnosis. When papules, nodules, or plaques develop on the head, neck, or torso in a middle-aged male accompanied by lymphadenopathy, there must be a high index of suspicion that these lesions are metastatic lymphomatous deposits. Definitive histologic diagnosis on a skin biopsy specimen is difficult. In this situation, it is best to rely on histologic patterns seen in lymphoid tissue along with cellular marker studies. An elderly patient having bone pain, anemia, elevated blood calcium level, and renal failure along with purplish or skin-colored nodules and plaques on the trunk has a good chance of having multiple myeloma. Biopsying these lesions is most certain to reveal atypical plasma cells, and blood immunoelectrophoresis will demonstrate characteristic monoclonal gammopathy. There are two malignancies seen in children under 3 years of age that often times affect the skin in a characteristic fashion. Letterer-Siwe disease, which is distinguished from other histocytic disorders by its cell of origin, the Langerhans cell, clinically

  3. Les séquelles de brûlures cervicales: aspects épidémiologique, clinique et thérapeutique au Maroc

    Science.gov (United States)

    Rafik, Amine; Chabak, Hakim; Diouri, Mounia; Bahechar, Naïma; Chlihi, Abdessamad

    2015-01-01

    Les séquelles de brûlures cervicales représentent une entité fréquente des séquelles de brûlure, elles affectent la fonction, l'esthétique et l’état psychologique des patients et peuvent être de traitement difficile. Il s'agit d'une étude rétrospective étalée sur 5 ans de Mars 2009 au Octobre2014, réalisée au centre national des brûlés et de chirurgie plastique au CHU Ibn Rochd Casablanca. Nous avons analysé les caractéristiques épidémiologiqueset cliniques ainsi que les indications et les résultats thérapeutiques chez 300 patients présentant des rétractions cervicales post-brûlure, suivis dans notre formation. Les jeunes femmes étaient le plus souvent touchées (56%). la brûlure thermique par flamme de butane dans le cadre d'accident domestique était l’étiologie la plus fréquente (91%).75% des patients ont été pris en charge dans un délai de 18 mois après avoir présenté une incapacité fonctionnelle. Les brides cervicales modérées et sévères sont les plus fréquentes et représentent respectivement 60% et 16% des cas. Le traitement chirurgical a fait appel aux greffes cutanées dans 67%des cas, aux plasties locales dans 24%des cas et aux lambeaux dans 24% des cas, les résultats sont jugés bons dans 75%des cas et moyens dans 18% des cas, tandis que les cas restants (7%) ont nécessité une reprise chirurgicale. Le traitement des brides cervicales doit être associé à un programme de rééducation adapté, afin d'assurer la pérennité des résultats fonctionnels et esthétiques. PMID:26301017

  4. Les dimensions émotionnelles du terrorisme

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    Benjamin Ducol

    2013-10-01

    Full Text Available Par une volonté louable de rompre avec des approches psychologisantes du phénomène terroriste dominantes au cours des années 1960-70, les recherches contemporaines en matière de terrorisme(s et de violence(s politique(s ont très largement mis l’emphase sur la figure du « terroriste » comme acteur rationnel et stratégique. Face aux limites des approches rationalistes de l’engagement radical qui envisagent de manière réductionniste les individus au travers d’un calcul rationnel univoque en terme de coûts et d’incitatifs à l’action, il nous apparaît important de réintégrer dans les réflexions théoriques sur les phénomènes terroristes, les émotions afin d’en interroger le rôle dans la production d’une trajectoire violente. Le présent article entend proposer à cet égard un bilan critique des travaux universitaires actuels autour de l’engagement terroriste et une réflexion théorique mettant en lumière les contours d’un futur agenda de recherche accordant une place plus importante aux ressorts émotionnels de la violence politique clandestine. Contemporary research on terrorism(s and political violence(s have largely put the emphasis on the figure of the "terrorist" as rational and strategic player, in a break with psychoanalytical approaches to terrorism that were dominant from the 1960-1970’s. Given the limitations of rationalist approaches to radical commitment, and considering how reductionist is the understanding of individual participation to terrorism related activities through a rational calculation framework in terms of costs and incentives to action, it is important to reintegrate in the theoretical reflections on terrorist phenomena how emotions can play a role in leading potential terrorists down a violent path. This paper presents a critical assessment of current academic work surrounding the issue of violent radicalization and involvement in terrorism, and engages in a theoretical debate

  5. Les évolutions de la norme électrique

    CERN Document Server

    Gallauziaux, Thierry

    2014-01-01

    Découvrez pièce par pièce les évolutions de la norme électrique (NF C 15-100 applicable depuis le 1er juin 2003), et les équipements minimaux requis : nombre de socles de prises de courant, emplacement des points d'éclairages, prises de communication... Sachez choisir les nouveaux dispositifs de protection des circuits, désormais obligatoires : les interrupteurs différentiels de type A, les dispositifs de coupure du fil pilote des chauffages électriques, le parafoudre... Ce qu'il faut savoir sur les nouvelles prises téléphoniques et le réseau de communication domestique pour accueillir les nouveaux services multimédias et de communication (téléphonie, TV, Internet...).

  6. Evaluation of a direct immunofluorescent antibody (difma test using Leishmania genus - specific monoclonal antibody in the routine diagnosis of cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Martha E. Chico

    1995-06-01

    Full Text Available A direct immunofluorescent antibody (DIFMA test using a Leishmania genus- specific monoclonal antibody was evaluated in the routine diagnosis of cutaneous leishmaniasis (CL in Ecuador. This test was compared with the standard diagnostic techniques of scrapings, culture and histology. Diagnostic samples were taken from a total of 90 active dermal ulcers from patients from areas of Ecuador known to be endemic for cutaneous leishmaniasis. DIFMA was positive in all lesions. It was shown to be significantly superior to standard diagnostic methods either alone or in combination. The sensitivity of DIFMA did not diminish with chronicity of lesions. This test proved to be extremely useful in the routine diagnosis of CL because it is highly sensitive, is easy to use and produces rapid results.O método de imunofluorescência direta (DIFMA, com anticorpos monoclonais gênero- específicos para Leishmania, foi avaliado na rotina diagnostica da leishmaniose cutânea no Equador. O método foi comparado com técnicas diagnosticas de rotina: o esfregaço, a cultura e o exame histopatolôgico. As amostras para o diagnóstico foram obtidas de um total de 90 lesões cutâneas ativas, de doentes das ãreas do Equador, endêmicas para leishmaniose cutânea. O DIFMA foi positivo em todas as lesões, com resultados significativamente superior aos métodos diagnósticos de rotina, isolado ou em combinação. A sensibilidade do DFIMA não diminui em lesões crônicas. O método mostra-se muito útil no diagnóstico de leishmaniose cutânea, pela sua sensibilidade, rapidez e facilidade de execução.

  7. OGM Diffusion des OGM et impact pour les agriculteurs : quels sont les liens ?

    Directory of Open Access Journals (Sweden)

    Lemarie Stéphane

    2001-05-01

    Full Text Available Les OGM actuellement sur le marché présentent des innovations sur des fonctions de protection des plantes. Selon les problèmes de protection des plantes, les gains des agriculteurs liés à l’adoption des OGM sont très variables. Cette hétérogénéité pose d’importants problèmes méthodologiques pour pouvoir estimer correctement la distribution des gains pour l’ensemble des agriculteurs. Une synthèse de plusieurs études américaines est réalisée ici et met bien en évidence la diversité des méthodes utilisées, chacune d’elles présentant ses avantages et ses limites. Globalement, si la diffusion des OGM est un fait indéniable, les études ne permettent pas de tirer des conclusions aussi nettes quant à l’impact des OGM pour tous les agriculteurs qui adoptent ces produits, et cela en particulier pour le soja. Cette absence de conclusion s’explique en grande partie par la difficulté à mesurer certains facteurs qui influencent le comportement d’adoption, comme par exemple la simplification de la conduite des cultures. En contrepartie, il faut noter que les études présentées ici ne prennent pas en compte un certain nombre d’effets indirects qui peuvent faire diminuer les gains des agriculteurs.

  8. Photonic Metamaterials for Defence and Security Applications (Les meta-materiaux photoniques pour les applications de defense et de securite)

    Science.gov (United States)

    2008-04-01

    exceptionnelles qui ne sont pas facilement observables dans les matériaux naturels . La plupart des recherches sur les méta-matériaux ont été consacrées à...matériaux naturels ) est une des principales raisons qui a poussé les chercheurs à approfondir leurs études sur les méta-matériaux. Avec un index...rapports signal/bruit plus importants, une vitesse plus élevée, une taille réduite, et une gamme plus large pour les systèmes de capteurs optiques

  9. Epidemiological aspects of cutaneous malignant melanoma (review).

    Science.gov (United States)

    Serraino, D; Fratino, L; Gianni, W; Campisi, C; Pietropaolo, M; Trimarco, G; Marigliano, V

    1998-01-01

    There is an increasing interest in the etiology of cutaneous malignant melanoma (CMM). Once considered a rare tumour, CMM is now the fourth commonest cancer in Australia and New Zeland, the tenth in the Usa, Canada and Scandinavia and the eighteenth in Great Britain. The growing scientific concern on the urgent need to highlight the cause/s of CMM is well documented by the large number of well-designed and well-conducted epidemiological studies reported in the last two decades. Such studies facilitated testing of many etiological hypotheses derived from earlier descriptive investigations and contributed to significant progress in understanding the etiology of such disease. The quantification of the extent to which the increases in CMM incidence and mortality rates are related to new lifestyles and to new patterns of exposure to potential carcinogenetic agents is essential in order to establish an appropriate preventive strategy. In population of mainly European origin a substantial proportion of the increased incidence of CMM is attributable to steady change from predominantly occupational to predominantly recreational exposure to solar radiation. Therefore the present review puts particular emphasis on exposure to sunlight as well as to artificial ultraviolet light, as modifiable causes of CMM. Incidence and mortality data and other potential risk factors for the development of CMM will also be briefly reviewed.

  10. Differentiation in cutaneous adnexal tumors: Immunohistochemical study

    Directory of Open Access Journals (Sweden)

    Figen BARUT

    2006-09-01

    Full Text Available Cutaneous adnexal neoplasms are rare tumors that display differentiation in different ways. The aim of this study is, to present embryonic developmental properties and to determine the way of differentiation of adnexal neoplasms by evaluating the immunohistochemical expression of various markers.Forty-seven cases with adnexal tumors enrolled in this study. Histopathologic groups of these 47 cases were: 15 (32% hair follicle tumors, 11 (23.4% sebaceous tumors, 8 (17% apocrine tumors, and 13 (27.6% eccrine tumors. CK5-6, CK6, CK7, CK8, CK10, CK19, GCDFP-15, carcinoembryonic antigen, epithelial membrane antigen and S100 protein expressions were examined by immunohistochemical methods.As a result of this immunohistochemical study it was concluded that the expression of CK5-6 and CK8 carries more importance than other markers in determining certain types of differentiation of hair follicle tumors. It was also determined that, epithelial membrane antigen expression is important for the diagnosis of sebaceous tumors and the markers like CK8, CK10 and carcinoembryonic antigen may aid for the same purpose as well. It was found that, GCDFP-15 as well as CK5-6 expressions are significant for apocrine tumors, and carcinoembryonic antigen reaction as well as CK8 positivity will aid in determining differentiation of eccrine tumors. The presence of similar CK6 expression in all kinds of adnexal tumors has demonstrated that this marker is useless in differential diagnosis.

  11. Acceleration of cutaneous wound healing by brassinosteroids.

    Science.gov (United States)

    Esposito, Debora; Rathinasabapathy, Thirumurugan; Schmidt, Barbara; Shakarjian, Michael P; Komarnytsky, Slavko; Raskin, Ilya

    2013-01-01

    Brassinosteroids are plant growth hormones involved in cell growth, division, and differentiation. Their effects in animals are largely unknown, although recent studies showed that the anabolic properties of brassinosteroids are possibly mediated through the phosphoinositide 3-kinase/protein kinase B signaling pathway. Here, we examined biological activity of homobrassinolide (HB) and its synthetic analogues in in vitro proliferation and migration assays in murine fibroblast and primary keratinocyte cell culture. HB stimulated fibroblast proliferation and migration and weakly induced keratinocyte proliferation in vitro. The effects of topical HB administration on progression of wound closure were further tested in the mouse model of cutaneous wound healing. C57BL/6J mice were given a full-thickness dermal wound, and the rate of wound closure was assessed daily for 10 days, with adenosine receptor agonist CGS-21680 as a positive control. Topical application of brassinosteroid significantly reduced wound size and accelerated wound healing in treated animals. mRNA levels of transforming growth factor beta and intercellular adhesion molecule 1 were significantly lower, while tumor necrosis factor alpha was nearly suppressed in the wounds from treated mice. Our data suggest that topical application of brassinosteroids accelerates wound healing by positively modulating inflammatory and reepithelialization phases of the wound repair process, in part by enhancing Akt signaling in the skin at the edges of the wound and enhancing migration of fibroblasts in the wounded area. Targeting this signaling pathway with brassinosteroids may represent a promising approach to the therapy of delayed wound healing.

  12. Cutaneous silent period in myofascial pain syndrome.

    Science.gov (United States)

    Kilinc, Ozden; Sencan, Savas; Ercalik, Tulay; Koytak, Pinar Kahraman; Alibas, Hande; Gunduz, Osman Hakan; Tanridag, Tulin; Uluc, Kayihan

    2017-09-06

    An increased response to painful stimuli without spontaneous pain suggests a role of central hyperexcitability of pain pathways in the pathogenesis of myofascial pain syndrome (MPS). In this study we aimed to test the hypothesis that spinal pain pathways are affected in MPS. We used cutaneous silent period (CSP) parameters to demonstrate the hyperexcitability of spinal pain pathways in MPS. Twenty-nine patients diagnosed with MPS and 30 healthy volunteers were included in the study. The CSP recordings were performed in the right upper and left lower extremities. In both upper and lower extremities, patients had prolonged CSP latencies (P = 0.034 and P = 0.049 respectively) and shortened CSP durations (P = 0.009 and P = 0.008, respectively). Delayed and shortened CSP in MPS patients implies dysfunction in the inhibitory mechanism of the spinal/supraspinal pain pathways, suggesting central sensitization in the pathogenesis of MPS and supporting our research hypothesis. Muscle Nerve, 2017. © 2017 Wiley Periodicals, Inc.

  13. Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation.

    Science.gov (United States)

    Lahiry, Sandeep; Choudhury, Shouvik; Mukherjee, Ayan; Bhunya, Prajesh Kiran; Bala, Moumita

    2017-02-01

    Polymyxin B is a polypeptide-antibiotic, primarily used for resistant Gram-negative infections, first obtained from bacterium Bacillus polymyxa in the late 1940s. Antibiotic spectrum are restricted to mainly gram negative bacterias like Enterobacter, E. coli, Klebsiella, Salmonella, Pasteurella, Bordetella, Shigella; and particularly organisms like Pseudomonas aeruginosa and Acinetobacter baumannii, which are extremely potent to acquire antibiotic resistance. Side effects include neurotoxicity and acute renal tubular necrosis. Here, we present a rare case of skin hyper-pigmentation in a 65-year-old elderly male of Indian origin, diagnosed as a case of Multi-Drug Resistant (MDR) Klebsiella pneumonia, treated with intravenous antibiotics. The manifestations were observed after 4 days of Polymyxin B therapy initiation. All other concomitant drugs, infections, or immunologic disorders that, could have caused this symptom, were carefully excluded. An objective causality assessment reveals that, the cutaneous hyperpigmentation was possibly associated with Polymyxin B therapy, though further studies may be needed to explain the underlying mechanism.

  14. Fatal cutaneous mucormycosis after kidney transplant.

    Science.gov (United States)

    Davuodi, Setareh; Manshadi, Seyed Ali Dehghan; Salehi, Mohammad Reza; Yazdi, Farhad; Khazravi, Mona; Fazli, Jafar Taghizade

    2015-02-01

    Mucormycosis is an uncommon opportunistic infection that is caused by Mucorales from the Zygomycetes class. Patients with severe immunodeficiency admitted to the hospital are at greatest risk for developing this infection. Mucormycosis usually is transmitted in humans by inhalation or inoculation of spores in the skin or mucous membranes. A 66-year-old man developed a surgical wound infection at 1 week after kidney transplant that did not improve despite broad-spectrum antibiotics and debridement. He was transferred to our hospital 45 days after transplant and had fever and a large purulent wound that was surrounded by a black necrotizing margin. Immunosuppressive drugs were discontinued and the dosage of prednisolone was decreased. Massive debridement was performed but was incomplete because he had full-thickness abdominal wall necrosis. Histopathology showed broad fungal hyphae without septation, consistent with the diagnosis of mucormycosis. Despite antifungal therapy with amphotericin B and additional debridement, the patient died of septic shock at 52 days after kidney transplant. Cutaneous fungal infections should be considered in the differential diagnosis of any nonhealing infected wound that does not respond to broad-spectrum antibiotics, especially in patients with predisposing risk factors such as transplant.

  15. [NMF and cosmetology of cutaneous hydration].

    Science.gov (United States)

    Marty, J-P

    2002-01-01

    In the stratum corneum, the water binds to the intracellular hygroscopic and hydrosoluble substances called "natural moisturizing factors" or NMF. These "natural moisturizing factors" contained in the corneocytes are formed during epidermal differentiation and may represent up to 10 p. cent of the corneocyte mass. They are principally amino acids, carboxylic pyrrolidone acid, lactic acid, urea, glucose and mineral ions. Keratinization plays an important part in the formation of NMF that exhibit strong osmotic potential attracting the water molecules. The binding of water to NMF is the static aspect of cutaneous hydration. The second, dynamic, aspect is related to the selective permeability of the stratum corneum and to its lipid barrier properties, the permeability of which depends on the integrity and nature of the inter-corneocyte lipids and their lamellar organization between the cells. In these conditions, hydration cosmetics rely on two concepts that can be isolated or associated: the supply of hydrophilic substances to the stratum corneum, capable of attracting and retaining water (moisturizer) or capable of restoring the barrier in order to restore normal water loss or of protecting it against aggression (occlusive).

  16. Effect of astaxanthin on cutaneous wound healing.

    Science.gov (United States)

    Meephansan, Jitlada; Rungjang, Atiya; Yingmema, Werayut; Deenonpoe, Raksawan; Ponnikorn, Saranyoo

    2017-01-01

    Wound healing consists of a complex series of convoluted processes which involve renewal of the skin after injury. ROS are involved in all phases of wound healing. A balance between oxidative and antioxidative forces is necessary for a favorable healing outcome. Astaxanthin, a member of the xanthophyll group, is considered a powerful antioxidant. In this study, we investigated the effect of topical astaxanthin on cutaneous wound healing. Full-thickness dermal wounds were created in 36 healthy female mice, which were divided into a control group and a group receiving 78.9 µM topical astaxanthin treatment twice daily for 15 days. Astaxanthin-treated wounds showed noticeable contraction by day 3 of treatment and complete wound closure by day 9, whereas the wounds of control mice revealed only partial epithelialization and still carried scabs. Wound healing biological markers including Col1A1 and bFGF were significantly increased in the astaxanthin-treated group since day 1. Interestingly, the oxidative stress marker iNOS showed a significantly lower expression in the study. The results indicate that astaxanthin is an effective compound for accelerating wound healing.

  17. Effect of astaxanthin on cutaneous wound healing

    Directory of Open Access Journals (Sweden)

    Meephansan J

    2017-07-01

    Full Text Available Jitlada Meephansan,1 Atiya Rungjang,1 Werayut Yingmema,2 Raksawan Deenonpoe,3 Saranyoo Ponnikorn3 1Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand; 2Laboratory Animal Centers, Thammasat University, Pathum Thani, Thailand; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand Abstract: Wound healing consists of a complex series of convoluted processes which involve renewal of the skin after injury. ROS are involved in all phases of wound healing. A balance between oxidative and antioxidative forces is necessary for a favorable healing outcome. Astaxanthin, a member of the xanthophyll group, is considered a powerful antioxidant. In this study, we investigated the effect of topical astaxanthin on cutaneous wound healing. Full-thickness dermal wounds were created in 36 healthy female mice, which were divided into a control group and a group receiving 78.9 µM topical astaxanthin treatment twice daily for 15 days. Astaxanthin-treated wounds showed noticeable contraction by day 3 of treatment and complete wound closure by day 9, whereas the wounds of control mice revealed only partial epithelialization and still carried scabs. Wound healing biological markers including Col1A1 and bFGF were significantly increased in the astaxanthin-treated group since day 1. Interestingly, the oxidative stress marker iNOS showed a significantly lower expression in the study. The results indicate that astaxanthin is an effective compound for accelerating wound healing. Keywords: astaxanthin, wound healing, reactive oxygen species, antioxidant 

  18. Comorbidity of Leishmania major with cutaneous sarcoidosis

    Directory of Open Access Journals (Sweden)

    Hamideh Moravvej

    2014-01-01

    Full Text Available Background: leishmaniasis infection might manifest as sarcoidosis; on the other hand, some evidences propose an association between sarcoidosis and leishmaniasis. Most of the times, it is impossible to discriminate idiopathic sarcoidosis from leishmaniasis by conventional histopathologic exam. Aim: We performed a cross-sectional study to examine the association of sarcoidosis with leishmaniasis in histopathologically diagnosed sarcoidal granuloma biopsy samples by polymerase chain reaction (PCR. Materials and Methods: We examined paraffin-embedded skin biopsy samples obtained from patients with clinical and histopathological diagnosis as naked sarcoidal granuloma, referred to Skin Research Center of Shaheed Beheshti Medical University from January 2001 to March 2010, in order to isolate Leishmania parasite. The samples were reassessed by an independent dermatopathologist. DNA extracted from all specimens was analyzed by the commercially available PCR kits (DNPTM Kit, CinnaGen, Tehran, Iran to detect endemic Leishmania species, namely leishmania major (L. major. Results: L. major was positive in PCR of Eight out of twenty-five examined samples. Conclusion: Cutaneous leishmaniasis may be misinterpreted as sarcoidosis; in endemic areas, when conventional methods fail to detect Leishmania parasite, PCR should be utilized in any granulomatous skin disease compatible with sarcoidosis, regardless of the clinical presentation or histopathological interpretation.

  19. Self-healing juvenile cutaneous mucinosis.

    Science.gov (United States)

    Kołodziejczyk, Beata; Gazda, Agnieszka; Hernik, Elżbieta; Szczygielska, Izabela; Rutkowska-Sak, Lidia; Koprowska, Marta Legatowicz

    2017-01-01

    Girl, aged 4 years old, began the disease with pain of the lower extremities, fever up to 38°C and signs of upper airway infection. Then the patient developed oedema and redness of the whole face, thickened skin, subcutaneous nodular foldings of the frontal, occipital, cervical and axillary regions, extensor areas of the joints; fine, hard whitish nodules in the frontal region and over interphalangeal joints of the hands, pruritus; oedemas of the ankles, knees and joints of the hands, cervical lymphadenopathy and hepatomegaly. Blood tests at the moment of the diagnosis revealed elevation of markers of inflammation as ESR and CRP, leukocytosis, thrombocytosis, hypoalbuminemia, and hyper-alfa-2-globulinemia. Histopathological examination of the skin biopsy specimen and subcutaneous tissue revealed myxoid subcutaneous tissue located under the dermis and a section consisting of myxoid mesenchymal tissue with inflammatory infiltration by histiocytic cells. The presence of acid mucopolysaccharides in fields of the myxoid tissue was also observed. The self-healing juvenile cutaneous mucinosis (SJCM) was diagnosed.

  20. Mechanosensory neurons, cutaneous mechanoreceptors, and putative mechanoproteins.

    Science.gov (United States)

    Del Valle, M E; Cobo, T; Cobo, J L; Vega, J A

    2012-08-01

    The mammalian skin has developed sensory structures (mechanoreceptors) that are responsible for different modalities of mechanosensitivity like touch, vibration, and pressure sensation. These specialized sensory organs are anatomically and functionally connected to a special subset of sensory neurons called mechanosensory neurons, which electrophysiologically correspond with Aβ fibers. Although mechanosensory neurons and cutaneous mechanoreceptors are rather well known, the biology of the sense of touch still remains poorly understood. Basically, the process of mechanosensitivity requires the conversion of a mechanical stimulus into an electrical signal through the activation of ion channels that gate in response to mechanical stimuli. These ion channels belong primarily to the family of the degenerin/epithelium sodium channels, especially the subfamily acid-sensing ion channels, and to the family of transient receptor potential channels. This review compiles the current knowledge on the occurrence of putative mechanoproteins in mechanosensory neurons and mechanoreceptors, as well as the involvement of these proteins on the biology of touch. Furthermore, we include a section about what the knock-out mice for mechanoproteins are teaching us. Finally, the possibilities for mechanotransduction in mechanoreceptors, and the common involvement of the ion channels, extracellular membrane, and cytoskeleton, are revisited.