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Sample records for lent soma scale

  1. Conservative treatment of soft tissue sarcomas of the extremities. Functional evaluation with LENT-SOMA scales and the Enneking score

    International Nuclear Information System (INIS)

    Tawfiq, N.; Lagarde, P.; Thomas, L.; Kantor, G.; Stockle, E.; Bui, B.N.

    2000-01-01

    Objective. - The aim of this prospective study is the feasibility of late effects assessment by LENT-SOMA scales after conservative treatment of soft tissue sarcomas of the extremities and a comparison with the functional evaluation by the Enneking score. Patients and methods. - During the systematic follow-up consultations, a series of 32 consecutive patients was evaluated in terms of late effects by LENT SOMA scales and functional results by the Enneking score. The median time after treatment was 65 months. The treatment consisted of conservative surgery (all cases) followed by radiation therapy (29 cases), often combined with adjuvant therapy (12 concomitant radio-chemotherapy association cases out of 14). The assessment of the toxicity was retrospective for acute effects and prospective for the following late tissue damage: skin/subcutaneous tissues, muscles/soft tissues and peripheral nerves. Results. -According to the Enneking score, the global score for the overall series was high (24/30) despite four the scores zero for the psychological acceptance. According to LENT SOMA scales, a low rate of severe sequelae (grade 3-4) was observed. The occurrence of high-grade sequelae and their functional consequences were not correlated with quality of exeresis, dose of radiotherapy or use of concomitant chemotherapy. A complementarity was observed between certain factors of the Enneking score and some criteria of the LENTSOMA scales, especially of muscles/soft tissues. Conclusion. -The good quality of functional results was confirmed by the two mean scoring systems for late normal tissue damage. The routine use of LENT-SOMA seems to be more time consuming than the Enneking score (mean time of scoring: 1 3 versus five minutes). The LENT-SOMA scales are aimed at a detailed description of late toxicity and sequelae while the Enneking score provides a more global evaluation, including the psychological acceptance of treatment. The late effects assessment by the LENT-SOMA

  2. Late effects of normal tissues (lent) scoring system: the soma scale

    International Nuclear Information System (INIS)

    Mornex, F.; Pavy, J.J.; Denekamp, J.

    1997-01-01

    Radiation tolerance of normal tissues remains the limiting factor for delivering tumoricidal dose. The late toxicity of normal tissues is the most critical element of an irradiation: somatic, functional and structural alterations occur during the actual treatment itself, but late effects manifest months to years after acute effects heal, and may progress with time. The optimal therapeutic ratio ultimately requires not only complete tumor clearance, but also minimal residual injury to surrounding vital normal tissues. The disparity between the intensity of acute and late effects and the inability to predict the eventual manifestation of late normal tissue injury has made radiation oncologists recognize the importance of careful patient follow-up. There is so far no uniform toxicity scoring system to compare several clinical studies in the absence of a 'common toxicity language'. This justifies the need to establish a precise evaluation system for the analysis of late effects of radiation on normal tissues. The SOMA/LENT scoring system results from an international collaboration. European Organization Treatment of Cancer (EORTC) and Radiation Therapy Oncology Group (RTOG) have created subcommittees with the aim of addressing the question of standardized toxic effects criteria. This effort appeared as a necessity to standardize and improve the data recording, to then describe and evaluate uniform toxicity at regular time intervals. The current proposed scale is not yet validated, and should be used cautiously. (authors)

  3. Assessment of morbidity in carcinoma of the cervix: a comparison of the LENT SOMA scales and the Franco-Italian glossary

    International Nuclear Information System (INIS)

    Davidson, Susan E.; Burns, Meriel P.; Routledge, Jacqueline A.; Swindell, Ric; Bentzen, Soeren M.; West, Catharine M.L.

    2003-01-01

    Background and purpose: To assess the correlation between the LENT (late effects on normal tissue) SOMA (subjective objective management analytic) system and the Franco-Italian glossary scores of late morbidity in cervical cancer patients treated with radiation, and to compare the ability of the scoring systems to detect differences between radiation treatment groups. Materials and methods: The study was retrospective. Patients, invited to take part in the study, had radiotherapy for cervical cancer and had a minimum of 3 years follow-up with no evidence of recurrence. One hundred patients agreed to take part. LENT subjective data were obtained using a patient questionnaire approach in order to complete the scales as published. The LENT objective, management and Franco-Italian glossary scores were obtained by a physician. Correlations between scores and differences between treatment groups were examined using non-parametric tests. Results: The average LENT SOMA scores had a greater resolution than the maximum scores, and using the maximum score alone underestimated treatment morbidity. The Franco-Italian glossary scores correlated strongly with the LENT objective scores (ρ=0.61, P<0.0005), and less strongly with the LENT subjective scores (ρ=0.45, P<0.0005). Significant differences in morbidity between the radiation treatment groups were measured using both the LENT SOMA system and the Franco-Italian glossary. Conclusions: The maximum and average LENT scores should be reported for each subsite. The LENT objective scores correlated well with the scores obtained using the established Franco-Italian glossary, but the LENT system provided additional information on subjective treatment effects. Both systems were able to measure significant differences in morbidity between radiation treatment groups. In conclusion, the LENT SOMA system is a valid and comprehensive approach for scoring the late normal tissue effects of radiotherapy

  4. The impact of radiotherapy for carcinoma of the cervix on sexual function assessed using the LENT SOMA scales

    International Nuclear Information System (INIS)

    Davidson, Susan E.; Burns, Meriel P.; Routledge, Jacqueline A.; Swindell, Ric

    2003-01-01

    Background and purpose: As there are few studies examining the impact of radiotherapy on sexuality, we assessed the effect of radiotherapy for carcinoma of the cervix on sexual health and the ability of the LENT system to assess sexual function. Materials and methods: Using the vagina and sexual dysfunction scales of the LENT SOMA scales, subjective scores were measured prospectively before initiation of radiotherapy for 89 women, and at the following times after the start of treatment: 21, 70, 200, 400, 600 and 800 days. Results: There was considerable variation in pre-radiotherapy scores that was not related to disease stage (P=0.054), but was related to patient age (P=0.037, for the average vagina scores and P=0.039 for the maximum vagina scores) The scores were influenced by prior surgery (P<0.0005 for maximum and average vagina scores, P=0.042 average and 0.017 maximum sexual dysfunction scores). For 48 patients for whom data were available at the first three time points, the vagina scores decreased significantly by 70 days compared to pre-radiotherapy scores, but not for sexual dysfunction. There was heterogeneity in the pattern of changes of scores over time: for some women there was no change in vagina subsection score, some increased, and some decreased. Conclusions: The work has shown variation both in pre-treatment sexual function and in the pattern of changes seen following radiotherapy. Our questionnaire proved useful to score subjective sexual and vaginal problems as given in the LENT subjective scales. Further study is needed to assess the effectiveness of the scales in assessing late effects

  5. Conservative treatment of soft tissue sarcomas of the extremities. Functional evaluation with LENT-SOMA scales and the Enneking score; Traitement conservateur des sarcomes des tissus mous des membres. Evaluation du resultat fonctionnel selon l'echelle LENT-SOMA et le score de Enneking

    Energy Technology Data Exchange (ETDEWEB)

    Tawfiq, N.; Lagarde, P.; Thomas, L.; Kantor, G. [Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Service de Radiotherapie, 33 - Bordeaux (France); Stockle, E. [Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Service de Chirurgie, 33 - Bordeaux (France); Bui, B.N. [Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Service d' Oncologie Medicale, 33 - Bordeaux (France)

    2000-12-01

    Objective. - The aim of this prospective study is the feasibility of late effects assessment by LENT-SOMA scales after conservative treatment of soft tissue sarcomas of the extremities and a comparison with the functional evaluation by the Enneking score. Patients and methods. - During the systematic follow-up consultations, a series of 32 consecutive patients was evaluated in terms of late effects by LENT SOMA scales and functional results by the Enneking score. The median time after treatment was 65 months. The treatment consisted of conservative surgery (all cases) followed by radiation therapy (29 cases), often combined with adjuvant therapy (12 concomitant radio-chemotherapy association cases out of 14). The assessment of the toxicity was retrospective for acute effects and prospective for the following late tissue damage: skin/subcutaneous tissues, muscles/soft tissues and peripheral nerves. Results. -According to the Enneking score, the global score for the overall series was high (24/30) despite four the scores zero for the psychological acceptance. According to LENT SOMA scales, a low rate of severe sequelae (grade 3-4) was observed. The occurrence of high-grade sequelae and their functional consequences were not correlated with quality of exeresis, dose of radiotherapy or use of concomitant chemotherapy. A complementarity was observed between certain factors of the Enneking score and some criteria of the LENTSOMA scales, especially of muscles/soft tissues. Conclusion. -The good quality of functional results was confirmed by the two mean scoring systems for late normal tissue damage. The routine use of LENT-SOMA seems to be more time consuming than the Enneking score (mean time of scoring: 1 3 versus five minutes). The LENT-SOMA scales are aimed at a detailed description of late toxicity and sequelae while the Enneking score provides a more global evaluation, including the psychological acceptance of treatment. The late effects assessment by the LENT-SOMA

  6. Comparison of patient-reported late treatment toxicity (LENT-SOMA) with quality of life (EORTC QLQ-C30 and QLQ-H and N35) assessment after head and neck radiotherapy

    International Nuclear Information System (INIS)

    Ho, Kean Fatt; Farnell, Damien J.J.; Routledge, Jacqueline A.; Burns, Meriel P.; Sykes, Andrew J.; Slevin, Nick J.; Davidson, Susan E.

    2010-01-01

    Purpose: The patient's role in toxicity reporting is increasingly acknowledged but requires the adaptation and validation of toxicity reporting instruments for patient use as most toxicity scales are designed for physician use. Recording of radiotherapy related late toxicity is important and needs to be improved. A patient-scored symptom questionnaire of late treatment effects using LENT-SOMA was compared with a recognised quality of life tool (EORTC QLQ-C30/H and N35). Materials/methods: LENT-SOMA and EORTC QLQ-C30 patient questionnaires were prospectively completed by 220 head and neck cancer patients over 3 years and 72 completed EORTC QLQ-H and N35 questionnaires at 2 years post-radiotherapy. Results: Endpoints common to both questionnaires (pain, swallowing, dental pain, dry mouth, opening mouth, analgesics) were matched. Spearman rank correlation coefficients with ρ > 0.6 (P < 0.001) were obtained for all 'matched' scales except for analgesics scale, ρ = 0.267 (P < 0.05). There was good agreement between LENT-SOMA and EORTC QLQ-H and N35 except for analgesic endpoints. Global quality of life scores correlated negatively with average LENT-SOMA scores (P < 0.001). Significant differences in average LENT-SOMA scores between treatment modalities were found. The LENT-SOMA questionnaire has demonstrated a high Cronbach's α value (0.786) indicating good reliability. Conclusions: LENT-SOMA patient questionnaire results agreed well with those from the EORTC QLQ-H and N35 questionnaire for toxicity items where they could be compared explicitly, particularly for subjective endpoints. Patient-reported late toxicity had a negative impact on quality of life. The LENT-SOMA patient questionnaire is both reliable and sensitive to differences between patients treated with different modalities. A patient-based questionnaire is an important contributor to capturing late radiotherapy effects.

  7. Late radiation effects to the rectum and bladder in gynecologic cancer patients: the comparison of LENT/SOMA and RTOG/EORTC late-effects scoring systems

    International Nuclear Information System (INIS)

    Anacak, Yavuz; Yalman, Deniz; Oezsaran, Zeynep; Haydaroglu, Ayfer

    2001-01-01

    Purpose: To test the correlation of LENT/SOMA and RTOG/EORTC late-effect scales for rectum and bladder, 116 cases with gynecologic malignancies that were treated with radiotherapy were assessed with both scales. Methods and Materials: All cases had been treated at least 6 months before the date of assessment with external beam radiotherapy (50-54 Gy to midline) and 1-2 fractions of HDR brachytherapy (2x8.5 Gy to point-A for 32 inoperable cases; 1x9.25 Gy to 5-9 mm from the ovoid surface for 84 postoperative cases). The patients were questioned with both scales, and the correlation between the two scales was analyzed by Spearman's rho (rank correlation) test. Results: There were 64 cases with uterine cervix carcinoma and 52 cases with endometrium carcinoma, The overall (external + brachy) doses to ICRU points were 57.8±3.8 Gy for rectum and 59.3±4.9 Gy for bladder. The statistical analysis of LENT/SOMA and RTOG/EORTC scales revealed a very good correlation for rectum (r=0.81; p<0.01) and a good correlation for bladder (r=0.72; p<0.01). Conclusion: The LENT/SOMA system is a further step on the reporting of late radiation effects. Some modifications will improve its precision, and multicentric randomized studies are needed to test its validity

  8. Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT/SOMA, RTOG/EORTC, and NCI-CTC scoring systems

    International Nuclear Information System (INIS)

    Denis, Fabrice; Garaud, Pascal; Bardet, Etienne; Alfonsi, Marc; Sire, Christian; Germain, Thierry; Bergerot, Philippe; Rhein, Beatrix; Tortochaux, Jacques; Oudinot, Patrick; Calais, Gilles

    2003-01-01

    Purpose: To prospectively assess 5-year late toxicity in patients treated by concomitant radiochemotherapy for locally advanced oropharynx carcinoma using three different toxicity scales. Methods and Materials: A total of 226 patients were entered in a Phase III multicenter, randomized trial comparing radiotherapy alone (70 Gy in 35 fractions: Arm A) with concomitant radiochemotherapy (70 Gy in 35 fractions with three cycles of a 4-day regimen containing carboplatin and 5-fluorouracil: Arm B). Five living patients, free of local or distant recurrences, could not be evaluated for late toxicity. Forty-four patients were eligible for late toxicity with a median follow-up of 5 years. Late toxicity was evaluated by the radiation oncologist using a large questionnaire containing 120 mixed items of three scales (NCI-CTC, LENT/SOMA, and RTOG). The data were then transposed on separate scales using corresponding grades. Results: The 5-year overall survival rate was 22% in Arm B and 16% in Arm A (p=0.05). The 5-year locoregional control rate was 48% in Arm B and 25% in Arm A (p=0.002). The spinal cord was not affected by the concomitant adjunct of chemotherapy, and no deaths were caused by late toxicity. Using the three late toxicity scales, 100% of the patients treated with the combined modality (Arm B) developed one or more late complications vs. 94% in the radiotherapy-alone arm (Arm A). The difference was not statistically significant. The most commonly damaged organs (all Grade 1-4) were the salivary glands (100% in Arm B vs. 82% in Arm A, p<0.05), skin (78% vs. 47%, p<0.05), teeth (67% vs. 18%, p<0.05), mucosa (59% vs. 63% p = not significant), and mandible (44% vs. 12%, p<0.05). One or more Grade 3-4 complications occurred in 82% of the patients in Arm B vs. 47% in Arm A (p=0.02) but concerned only the teeth. The correlation between the RTOG and LENT/SOMA scale and between the NCI-CTC and LENT/SOMA scale were low for Grade 1-4 toxicity (near 30%). The transposability

  9. Long-term radiation sequelae after breast-conserving therapy in women with early-stage breast cancer: an observational study using the LENT-SOMA scoring system

    International Nuclear Information System (INIS)

    Fehlauer, Fabian; Tribius, Silke; Hoeller, Ulrike; Rades, Dirk; Kuhlmey, Antje; Bajrovic, Amira; Alberti, Winfried

    2003-01-01

    Purpose: To evaluate the long-term toxicity after breast-conserving therapy in women with early-stage breast cancer. Methods and Materials: Late toxicity according to the late effects of normal tissue-subjective, objective, management, and analytic (LENT-SOMA) criteria and cosmetic outcome (graded by physicians) were evaluated in 590 of 2943 women with early-stage breast cancer who were irradiated between 1983 and 1995 using the following fractionation schedules: group A, 1983-1987, 2.5 Gy 4x/wk to 60 Gy; group B, 1988-1993, 2.5 Gy 4x/wk to 55 Gy, group C, 1994-1995, 2.0 Gy 5x/wk to 55 Gy. Results: LENT-SOMA Grade 3-4 toxicity was observed as follows: group A (median follow-up 171 months; range 154-222 months), fibrosis 16% (7 of 45), telangiectasia 18% (8 of 45), and atrophy 4% (2 of 45); group B (median follow-up 113 months; range 78-164 months), pain 2% (8 of 345), fibrosis 10% (34 of 345), telangiectasia 10% (33 of 345), arm edema 1% (2 of 345), and atrophy 8% (27 of 345); and group C (median follow-up 75 months, range 51-96 months, n = 200), occurrence of Grade 3-4 late morbidity ≤2%. The cosmetic outcome was very good to acceptable in 78% (35 of 45) of patients in group A, 83% (286 of 345) in group B, and 94% (187 of 200) in group C. Conclusion: In our population, the long-term side effects after breast-conserving therapy were not rare, but were mainly asymptomatic. The LENT-SOMA breast module is a practical tool to assess radiation-induced long-term toxicity

  10. Materiales. Lentes de contacto. (I)

    OpenAIRE

    Lozano Prieto, Beatriz

    2017-01-01

    La función de una lente de contacto, al igual que la de unas lentes oftálmicas en gafas, es la compensación de las ametropías ya sea miopía, hipermetropía o astigmatismo. En este trabajo se realiza un estudio metodológico basado principalmente en la evolución de las lentes de contacto y de sus materiales, desde las primeras lentes de vidrio esclerales y corneales, pasando por las lentes de material plástico, las rígidas permeables a los gases, las de hidrogel, y finalmente a las lentes de ...

  11. Lentes progressivas: análise da potência do astigmatismo induzido

    Directory of Open Access Journals (Sweden)

    Celso Marcelo Cunha

    2013-06-01

    Full Text Available OBJETIVO: Avaliar a potência do astigmatismo induzido nas lentes progressivas em um deflexômetro. MÉTODOS: Foram incluídas onze lentes progressivas com poder longe de +1,00D e adição 2,00D para perto. Avaliou-se o astigmatismo induzido em doze pontos do campo intermediário, sendo seis de cada lado do corredor progressivo no deflexômetro. RESULTADOS: Existem diferenças significativas entre as somas dos astigmatismos induzidos de cada lado do corredor progressivo e no total geral nestas lentes estudadas, com coeficiente de variação com forte dispersão (CV 10 a 13%. CONCLUSÃO: Existe uma variação importante das potências dos astigmatismos induzidos nas lentes progressivas.

  12. A lente moderna

    Directory of Open Access Journals (Sweden)

    Maria Elisa Baptista

    2012-11-01

    Full Text Available Belo Horizonte, cidade moderna, abriga registros do surgimento da arquitetura moderna brasileira, flagrados na sua construção pela lente moderna do fotógrafo Wilson Baptista. Associar fragmentos das histórias arquitetônica e fotográfica nas décadas de 1930-1960 é o objetivo com este ensaio, baseado no relato pessoal da experiência de cada imagem. As referências arquitetônicas não se estendem além do necessário, por já terem sido publicadas por outros autores, limitando-se a referenciar o trabalho inventivo do fotógrafo, que traduz, em uma estética também moderna, a beleza da arquitetura belo-horizontina.

  13. Queratocone e lentes de contacto

    OpenAIRE

    Coutinho, I; Ramalho, M; Pedrosa, C; Pina, S; Mota, M; Santos, C; Vendrell, C

    2014-01-01

    Nos doentes com queratocone quando os óculos não possibilitam boa visão, as lentes de contacto são uma boa alternativa terapêutica. Há vários desenhos de lentes de contacto que podem ser utilizados na correção óptica do queratocone e a sua adaptação deve assegurar o menor trauma da córnea e conforto ao doente. Este trabalho pretende fazer fazendo-se breve revisão das lentes de contacto disponíveis no tratamento do queratocone.

  14. Lentes plegables suturadas a iris

    Directory of Open Access Journals (Sweden)

    Dunia Cruz Izquierdo

    Full Text Available Para la corrección quirúrgica de la afaquia existen en la actualidad varias técnicas quirúrgicas que permiten fijar los lentes intraoculares plegables o rígidos en cámara posterior suturados al iris o al sulcus ciliar. En estas circunstancias el cirujano determinará cuándo, dónde y el tipo de lente mejor a implantar. Se presenta un paciente con una afaquia traumática del ojo izquierdo, con agudeza visual sin corrección de movimiento de mano a 1 m. Se le realizó implante secundario de lente intraocular plegable de cámara posterior suturada al iris. En el examen biomicroscópico en lámpara de hendidura del ojo izquierdo se observó midriasis media paralítica, refracción dinámica de +11,00 (0,6 y tensión ocular normal. Se le realizó examen por bimicroscopía indirecta sin alteración. Al mes de operado la agudeza visual mejor corregida alcanzó la unidad de visión. Las complicaciones presentadas fueron ovalización de la pupila y depósitos de pigmentos de iris en el lente intraocular.

  15. Números reais e curiosidades das somas infinitas

    OpenAIRE

    Moreno, Priscila Klitzke

    2016-01-01

    Podemos encontrar muitas surpresas interessantes no estudo das somas infinitas de números reais (series). Nessa perspectiva, este trabalho traz um estudo sobre as somas infinitas e mostra algumas curiosidades sobre elas, em especial sobre a serie harmônica. Começamos nosso estudo sobre somas infinitas, considerando exemplos com interpretações geométricas que tornam o estudo de series mais atraente. Discutimos também propriedades aritméticas, comutativa e associativa, das somas ...

  16. Randvere Kool = Randvere School / Kristi Lents

    Index Scriptorium Estoniae

    Lents, Kristi, 1981-

    2013-01-01

    Kristi Lents-Esnari ja Marita Mätase (Allianss Arhitektid) kujundatud Randvere Kooli (G.H. Schüdlöffeli tee 4, Randvere küla, Viimsi) interjöörist. Hoone arhitekt Inga Raukas. Lühidalt Kristi Lents-Esnarist ja Marita Mätasest

  17. Lentes de contacto en el deporte

    Directory of Open Access Journals (Sweden)

    Lluïsa Quevedo i Junyent

    2007-06-01

    Full Text Available Tras una completa evaluación optométrica, la primera responsabilidad del especialista, es procurar al deportista amétrope (miope, hipermétrope, astígmata... una óptima calidad de visión, ya sea con gafas o, preferiblemente, con lentes de contacto, por las numerosas ventajas que éstas presentan para el deportista. En los últimos años, especialmente, la industria de las lentes de contacto viene experimentando una evolución imparable, con grandes innovaciones a nivel de materiales, diseños y frecuencias de reemplazo que se traducen en mayor calidad de visión, confort y seguridad para el usuario. Las lentes de contacto desechables (usar y tirar, suelen ser de primera elección para los deportistas. En esta línea se encuentra la lente de contacto Nike Max Sight, de reciente comercialización en nuestro país, y que sin duda, como ya está sucediendo en los EUA, puede comportar una pequeña revolución en el contexto deportivo

  18. Nuevas aplicaciones de las lentes de contacto

    OpenAIRE

    Blanco Menéndez, Patricia

    2017-01-01

    Revisión bibliográfica de los estudios para el seguimiento y monitorización de patologías de elevada prevalencia (glaucoma y diabetes mellitus) de una forma no invasiva y administración de fármacos mediante el uso de lentes de contacto. Grado en Optica y Optometría

  19. 7 CFR 1710.107 - Amount lent for acquisitions.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Amount lent for acquisitions. 1710.107 Section 1710... GUARANTEES Loan Purposes and Basic Policies § 1710.107 Amount lent for acquisitions. The maximum amount that will be lent for an acquisition is limited to the value of the property, as determined by RUS. If the...

  20. Soma of the Rigveda and an attempt to identify it.

    Science.gov (United States)

    Mahdihassan, S; Mehdi, F S

    1989-01-01

    Ephedra juice is used as the drink of longevity given even to the new born. This is an Aryan custom mentioned in Rigveda and followed even by the Romans. To trace the history of this custom would lead to identifying Soma = Ephedra. The original species of Ephedra or Soma proper would be Ephedra sinica, the Chinese plant. It is the one species with yellow stalks. This has been illustrated so that it confirms Rigveda speaking of Soma as "golden yellow." The name Soma is also a loan word from Chinese meaning "fire-yellow fibers of hemp." The plant Soma is described as "thousand boughs" and photographic evidence has been offered in support. Each stalk is rod-like resembling an arrow as Rigveda speaks of it. An illustration has been offered to show the plant with stalks which are straight and rod-like, comparable with an arrow.

  1. Lentes progressivas x lentes multifocais: um estudo baseado na geometria analítica do cone

    Directory of Open Access Journals (Sweden)

    Araújo Marília Cavalcante

    2004-01-01

    Full Text Available OBJETIVO: Compreender, por meio de figuras e funções matemáticas do cone, as lentes progressivas e mostrar que elas não são lentes multifocais porque, nelas, a refração da luz não obedece as leis da geometria euclidiana. MÉTODOS: Foi feito um estudo da geometria analítica do cone, com o programa de computador Auto-CAD 14, dando enfoque óptico às figuras geométricas obtidas com a sua secção. RESULTADOS: Pela análise das figuras obtidas da secção do cone, pudemos observar as superfícies que compõem as lentes progressivas. Estas superfícies são compostas de elipse, círculo, parábola e hipérbole. Diferente do que é dito na literatura, encontramos as elipses com diâmetro maior nas ordenadas e de mesmo sentido seguida por duas superfícies inferiores que são parábola e hipérbole e não o contrário. CONCLUSÕES: As lentes progressivas diferentemente das lentes multifocais apresentam prismas nos centros ópticos como decorrência da sua estrutura. No final, fizemos análise das suas formas mostrando o limite teórico da sua evolução.

  2. Soma térmica de algumas fases do ciclo de desenvolvimento da escala de COUNCE para cultivares Sul-Brasileiras de arroz irrigado Thermal time of some developmental phases of the COUNCE scale for irrigated rice cultivars grown in Southern Brazil

    Directory of Open Access Journals (Sweden)

    Nereu Augusto Streck

    2007-01-01

    Full Text Available A escala de COUNCE é uma escala de desenvolvimento de arroz recente que vem sendo gradativamente adotada no Brasil. No entanto, a duração das fases em ºC dia dessa escala ainda não está disponível para as cultivares brasileiras de arroz irrigado. Sendo assim, o objetivo deste trabalho foi determinar a soma térmica de algumas fases do ciclo de desenvolvimento da escala de COUNCE para cultivares Sul-Brasileiras de arroz irrigado, utilizando-se diversos métodos de cálculo e diferentes temperaturas cardinais ao longo do ciclo de desenvolvimento. Um experimento a campo foi desenvolvido em Santa Maria, RS, durante dois anos agrícolas (2003/2004 e 2004/2005 e com cinco épocas de semeadura em cada um deles. O delineamento experimental foi o inteiramente casualizado com quatro repetições. Cada repetição consistia de um vaso de 12 litros com 10 plantas. As datas dos estágios de desenvolvimento R2 (aparecimento do colar da folha bandeira e R9 (todos os grãos com casca marrom da escala de COUNCE foram registradas no colmo principal de cinco plantas por vaso. As cultivares utilizadas foram IRGA 421, IRGA 416, IRGA 417, IRGA 420, BR-IRGA 409, BRS 7 TAIM e EPAGRI 109. Considerando-se as temperaturas cardinais de 11 °C, 28 °C e 40 °C, a soma térmica para completar a fase emergência-R2 foi de 700-800 °C dia na cultivar muito precoce, 1000-1400 °C dia nas cultivares precoces e 1300-1700 °C dia nas cultivares médias e tardia, e a soma térmica para completar a fase R2-R9 foi de 400-700 °C dia e sem relação com o ciclo da cultivar.The COUNCE scale is a developmental scale recently proposed for rice and that is being used in Brazil. However, the duration of developmental phases of this scale in degree-days is not available for Brazilian irrigated rice cultivars. Thus, the objective of this study was to determine the thermal time of some developmental phases of the COUNCE scale in irrigated rice cultivars grown in Southern Brazil using

  3. Lentes de contacto em idade pediátrica

    OpenAIRE

    Mota, M; Vendrell, C; Ramalho, M; Santos, C; Pedrosa, C; Coutinho, I; Lopes, AS; Silva, D

    2015-01-01

    Revisão sobre os tipos de lentes de contacto para utilização na idade pediátrica. Regras de adaptação, indicações e contraindicações ao uso de lentes de contacto na criança. Descrição das melhores opções na afaquia.

  4. Pärt, Arvo: "Miserere", "Festina lente" / Volkmar Fischer

    Index Scriptorium Estoniae

    Fischer, Volkmar

    1991-01-01

    Uuest heliplaadist Pärt, Arvo: "Miserere", "Festina lente", "Sarah Was Ninety Years Old". The Hilliard Ensemble. Orchester der Beethovenhalle Bonn. Dirigent Dennis Russel Davies (ECM Records, distr Amigo)

  5. Leading tip drives soma translocation via forward F-actin flow during neuronal migration.

    Science.gov (United States)

    He, Min; Zhang, Zheng-hong; Guan, Chen-bing; Xia, Di; Yuan, Xiao-bing

    2010-08-11

    Neuronal migration involves coordinated extension of the leading process and translocation of the soma, but the relative contribution of different subcellular regions, including the leading process and cell rear, in driving soma translocation remains unclear. By local manipulation of cytoskeletal components in restricted regions of cultured neurons, we examined the molecular machinery underlying the generation of traction force for soma translocation during neuronal migration. In actively migrating cerebellar granule cells in culture, a growth cone (GC)-like structure at the leading tip exhibits high dynamics, and severing the tip or disrupting its dynamics suppressed soma translocation within minutes. Soma translocation was also suppressed by local disruption of F-actin along the leading process but not at the soma, whereas disrupting microtubules along the leading process or at the soma accelerated soma translocation. Fluorescent speckle microscopy using GFP-alpha-actinin showed that a forward F-actin flow along the leading process correlated with and was required for soma translocation, and such F-actin flow depended on myosin II activity. In migrating neurons, myosin II activity was high at the leading tip but low at the soma, and increasing or decreasing this front-to-rear difference accelerated or impeded soma advance. Thus, the tip of the leading process actively pulls the soma forward during neuronal migration through a myosin II-dependent forward F-actin flow along the leading process.

  6. Bacilos gram negativos, contaminantes más prevalentes en lentes de contacto blandos usados

    OpenAIRE

    Castiblanco, Diana; Rodríguez, Martha Fabiola; Mayorga C., Myriam Teresa

    2007-01-01

    Las bacterias son los contaminantes más frecuentes de los lentes de contacto. Objetivo: identificar el tipo de depósitos microbiológicos en lentes de contacto blando (LCB) usados. Materiales y Métodos: 100 lentes de contacto blandos de usuarios o de prueba  de las ópticas, recolectándose 25 lentes para cada grupo de la FDA (Grupo1, 2, 3 y 4, según el contenido de agua e ionicidad del polímero). Los lentes se almacenaron por 20 días en sus estuches individuales hasta su estudio. A cada lente, ...

  7. Psychosomatic symptoms as biomarkers: transcending the psyche-soma dichotomy.

    Science.gov (United States)

    Neuman, Yair

    2010-01-01

    Following the advancement in understanding dynamical systems, the author presents a novel metaphor of psychosomatic symptoms as low-dimensional biomarkers. This metaphor, which transcends the old binary of psyche-soma, resonates with classical psychoanalytic concepts and with Matte-Blanco's idea of repetition as indicative of dimensionality reduction. The relevance of this metaphor for explanation, diagnosis, and treatment is illustrated through a case study of a male patient suffering from hyperprolactinemia.

  8. Measurement of neuron soma size by fluorescent Nissl stain

    OpenAIRE

    sprotocols

    2015-01-01

    Authors: James Cronk, Noel Derecki & Jonathan Kipnis ### Abstract This protocol describes how to measure neuron soma size by fluorescent Nissl stain. Mice are sacrificed, and fixed by PFA perfusion. Brains are removed, and further PFA fixed, followed by sucrose cryoprotection. They are then snap frozen, sliced by cryostat, and stained with fluorescent Nissl as floating sections. Confocal microscopy is used to take images of neurons, and a computer graphics tablet is used to calculate ...

  9. Compression medullaire lente secondaire a un lymphome de Burkitt ...

    African Journals Online (AJOL)

    faciale à la fin du 1er mois et une récupération neurologique au bout d'un an. La localisation secondaire intra rachidienne d'un LB bien que rare doit être présente à l'esprit surtout en face d'une compression médullaire lente survenue dans un ...

  10. Amifostine as radioprotective agent for the rectal mucosa during irradiation of pelvic tumors. A phase II randomized study using various toxicity scales and rectosigmoidoscopy

    Energy Technology Data Exchange (ETDEWEB)

    Kouvaris, J.; Antypas, C.; Kokakis, J.; Vlahos, L. [Radiology-Radiotherapy Dept., National Technical Univ. of Athens (Greece); Kouloulias, V. [Radiology-Radiotherapy Dept., National Technical Univ. of Athens (Greece); Dept. of Electrical and Computer Engineering, Inst. of Communication and Computer Systems, National Technical Univ. of Athens (Greece); Malas, E. [Endoscopy-Gastroenterology Unit, Dept. of Surgical Oncology, Aretaieion Univ. Hospital, Athens (Greece); Michopoulos, S. [Dept. of Gastroenterology, Alexandra General Hospital of Athens (Greece); Matsopoulos, G. [Dept. of Electrical and Computer Engineering, Inst. of Communication and Computer Systems, National Technical Univ. of Athens (Greece)

    2003-03-01

    Aim: To evaluate the cytoprotective effect of amifostine against radiation-induced acute toxicity to the rectal mucosa. Patients and Methods: 36 patients irradiated for prostate or gynecologic cancer were randomized to receive amifostine (n = 18, group A) or not (n = 18, group B). The radiation-induced acute rectal toxicity was evaluated by using three different toxicity scales: WHO scale, EORTC/RTOG toxicity criteria, and a modified toxicity scale based on the LENT-SOMA grading scale and the endoscopic terminology of the World Organization for Digestive Endoscopy. The objective measurements were coming from flexible rectosigmoidoscopy performed at baseline and 1-2 days after completion of the radiotherapy schedule. Anterior-posterior fields were used in the gynecologic patients while 3-D conformal 4-field technique was applied in the prostate cancer patients. The area under the curve (AUC) for dose-volume histograms (DVHs) of the rectum was also assessed during a 3-D treatment planning schedule, and no significant differences were assessed between the two groups, indicating a homogeneous dose-volume effect. Results: Amifostine was well tolerated. No grade 2 or higher WHO and EORTC/RTOG acute toxicity was noted in group A, while acute rectal toxicity ({>=} grade 1) was observed in 16/18 patients of group B versus 2/18 of group A (p < 0.001). The onset as well as the duration of acute rectal toxicity were significantly improved in group A (p = 0.002). Rectosigmoidoscopy revealed more severe rectal mucositis in noncytoprotected patients (group B), and modified LENT-SOMA overall mucositis grading score was significantly lower in group A (p = 0.003). Conclusion: Amifostine seems to have a significant cytoprotective efficacy in acute radiation-induced rectal mucositis in terms of symptomatic and objective endpoints. (orig.)

  11. Amifostine as radioprotective agent for the rectal mucosa during irradiation of pelvic tumors. A phase II randomized study using various toxicity scales and rectosigmoidoscopy

    International Nuclear Information System (INIS)

    Kouvaris, J.; Antypas, C.; Kokakis, J.; Vlahos, L.; Kouloulias, V.; Malas, E.; Michopoulos, S.; Matsopoulos, G.

    2003-01-01

    Aim: To evaluate the cytoprotective effect of amifostine against radiation-induced acute toxicity to the rectal mucosa. Patients and Methods: 36 patients irradiated for prostate or gynecologic cancer were randomized to receive amifostine (n = 18, group A) or not (n = 18, group B). The radiation-induced acute rectal toxicity was evaluated by using three different toxicity scales: WHO scale, EORTC/RTOG toxicity criteria, and a modified toxicity scale based on the LENT-SOMA grading scale and the endoscopic terminology of the World Organization for Digestive Endoscopy. The objective measurements were coming from flexible rectosigmoidoscopy performed at baseline and 1-2 days after completion of the radiotherapy schedule. Anterior-posterior fields were used in the gynecologic patients while 3-D conformal 4-field technique was applied in the prostate cancer patients. The area under the curve (AUC) for dose-volume histograms (DVHs) of the rectum was also assessed during a 3-D treatment planning schedule, and no significant differences were assessed between the two groups, indicating a homogeneous dose-volume effect. Results: Amifostine was well tolerated. No grade 2 or higher WHO and EORTC/RTOG acute toxicity was noted in group A, while acute rectal toxicity (≥ grade 1) was observed in 16/18 patients of group B versus 2/18 of group A (p < 0.001). The onset as well as the duration of acute rectal toxicity were significantly improved in group A (p = 0.002). Rectosigmoidoscopy revealed more severe rectal mucositis in noncytoprotected patients (group B), and modified LENT-SOMA overall mucositis grading score was significantly lower in group A (p = 0.003). Conclusion: Amifostine seems to have a significant cytoprotective efficacy in acute radiation-induced rectal mucositis in terms of symptomatic and objective endpoints. (orig.)

  12. Procedimiento para elaborar una lente intraocular monofocal asférica isoplanática y lente obtenida empleando dicho procedimiento

    OpenAIRE

    Barbero, Sergio; Marcos, Susana; Dorronsoro, Carlos; Montejo, Javier; Salazar Salegui, Pedro

    2010-01-01

    Procedimiento para elaborar una lente intraocular monofocal asférica isoplanática y lente obtenida empleando dicho procedimiento. Permite obtener lentes oftálmicas monofocales asféricas isoplanáticas en un rango visual de hasta 25º (preferentemente hasta 10º) de amplitud. El procedimiento comprende las etapas de: 1.- Definición matemática de un modelo de ojo afáquico; 2.- Definición matemática de un modelo de lente intraocular; 3.- Definición matemática de la implantac...

  13. Psyche and soma: New insights into the connection.

    Science.gov (United States)

    Kumar, Rahul; Yeragani, Vikram K

    2010-01-01

    The interaction of Psyche and Soma are well known and this interaction happens through a complex network of feedback, medication, and modulation among the central and autonomic nervous systems, the endocrine system, the immune system, and the stress system. These systems, which were previously considered pristinely independent, in fact, interact at myriad levels. Psychoneuroimmunology (PNI) is an emerging discipline that focuses on various interactions among these body systems and provides the underpinnings of a scientific explanation for what is commonly referred to as the mind-body connection. This article reviews the relevant literature with an emphasis on Indian research.

  14. A brief account of the fractions of soma.

    Science.gov (United States)

    Mahdihassan, S

    1990-04-01

    Soma was originally Sauma as the Sanskrit form of the Avesta name Haoma. It is a loan word from the Chinese term, Hao-Ma, fire coloured hempior fibrous items like hemp and also coloured yellow with a tinge of brown. The Aryans as hunters took its juice as anti-fatigue drink. It was extolled as panacea and even as drink of longevity. The plant and its stalks were crushed between stones to produce juice. There arose different fractions and these have been given in a regular chart here.

  15. Úlceras corneales en usuarios de lentes de contacto

    Directory of Open Access Journals (Sweden)

    Darlen Rodríguez Rivero

    Full Text Available El empleo de lentes de contacto se ha incrementado a nivel mundial. En la actualidad su uso no se restringe solamente a la corrección óptica, sino que se utilizan con fines terapéuticos, ya que generan comodidad y estética en múltiples afecciones oculares. Es de esperar el creciente aumento de las complicaciones relacionadas con el uso de estos, por ser la queratitis bacteriana potencialmente grave y devastadora para el globo ocular. Se realizó una revisión bibliográfica acerca de las úlceras corneales en portadores de lentes de contacto con el objetivo de describir su epidemiología y las formas de prevenir esta complicación.

  16. Observaci\\'on de lentes gravitatorias con ALMA

    OpenAIRE

    Bonilla, A.; Toloza, O.; Fuentes, I.; Motta, V.

    2016-01-01

    Gravitational lensing is a fundamental tool for cosmology. A recent instrument which will provide more information for models of these objects is ALMA. Our goal is to select lens candidates to observe with ALMA and then model them using GravLens Software. We had selected 12 quadruple images systems from the CASTLES database, which show a high probability of observing extended sources in the submillimetric range. These new data will allow us to improve existing models. Las lentes gravitatorias...

  17. Lentes esclerales: características e indicaciones

    Directory of Open Access Journals (Sweden)

    Oreste Mariño Hidalgo

    Full Text Available Los lentes de contacto esclerales o de apoyo escleral constituyen una de las opciones terapéuticas más relevantes en el tratamiento y corrección óptica de las enfermedades corneales primaria o secundarias, que traen como consecuencia alteraciones de la curvatura, de la regularidad de la superficie y de su transparencia. La evolución y el desarrollo de este tipo de lentes han abierto un diapasón de múltiples opciones para su uso. En la actualidad se prescriben por numerosos especialistas y ópticas del mundo con una gran aceptación y confort de los pacientes que los utilizan, lo que ha popularizado su comercialización. Realizamos una búsqueda de diversos artículos publicados en los últimos diez años para profundizar en el conocimiento de las características e indicaciones de los lentes de contacto esclerales.

  18. Embracing First-Person Perspectives in Soma-Based Design

    Directory of Open Access Journals (Sweden)

    Kristina Höök

    2018-02-01

    Full Text Available A set of prominent designers embarked on a research journey to explore aesthetics in movement-based design. Here we unpack one of the design sensitivities unique to our practice: a strong first person perspective—where the movements, somatics and aesthetic sensibilities of the designer, design researcher and user are at the forefront. We present an annotated portfolio of design exemplars and a brief introduction to some of the design methods and theory we use, together substantiating and explaining the first-person perspective. At the same time, we show how this felt dimension, despite its subjective nature, is what provides rigor and structure to our design research. Our aim is to assist researchers in soma-based design and designers wanting to consider the multiple facets when designing for the aesthetics of movement. The applications span a large field of designs, including slow introspective, contemplative interactions, arts, dance, health applications, games, work applications and many others.

  19. [Therapeutic qualities of a lente preparation of swine insulins manufactured by Pharmachem].

    Science.gov (United States)

    Andreev, D; Bozadzhieva, E; Pampulov, L; Penchev, I; Uzunova, B

    1977-01-01

    The therapeutic effect of swine insulin preparation Lente, "Pharmachim" production was studied in 50 diabetics. Its hypoglycemizing activitis compared with that of standardized insulin Lente--"Novo", extract of bovine pancreas. The Bulgarian preparation was found to be very similar to the preparation Lente-Novo in its pharma-codynamic properties and could successfully be used in the diabetes melitus treatment. Insulin Lente Pharmachim is presumed to have lower antigenicity as an extract of swine pancreas, which is actually its great advantage for the therapeutic practice.

  20. Spike sorting based upon machine learning algorithms (SOMA).

    Science.gov (United States)

    Horton, P M; Nicol, A U; Kendrick, K M; Feng, J F

    2007-02-15

    We have developed a spike sorting method, using a combination of various machine learning algorithms, to analyse electrophysiological data and automatically determine the number of sampled neurons from an individual electrode, and discriminate their activities. We discuss extensions to a standard unsupervised learning algorithm (Kohonen), as using a simple application of this technique would only identify a known number of clusters. Our extra techniques automatically identify the number of clusters within the dataset, and their sizes, thereby reducing the chance of misclassification. We also discuss a new pre-processing technique, which transforms the data into a higher dimensional feature space revealing separable clusters. Using principal component analysis (PCA) alone may not achieve this. Our new approach appends the features acquired using PCA with features describing the geometric shapes that constitute a spike waveform. To validate our new spike sorting approach, we have applied it to multi-electrode array datasets acquired from the rat olfactory bulb, and from the sheep infero-temporal cortex, and using simulated data. The SOMA sofware is available at http://www.sussex.ac.uk/Users/pmh20/spikes.

  1. Monilapsisten perheiden lentäen tapahtuvat valmismatkat ulkomaille

    OpenAIRE

    Argillander, Rita

    2015-01-01

    Tässä opinnäytetyössä pyrittiin selvittämään ulkomaille lentäen matkuste-levien monilapsisten perheiden valmismatkan sisältöä sekä osto- ja valin-taprosessiin vaikuttavia tekijöitä. Työssä kartoitettiin mitä monilapsiset perheet arvostavat ja tarvitsevat viihtyäkseen valmismatkalla. Työn tarkoi-tus oli auttaa matkantarjoaja Apollomatkoja kehittämään vanhoja ja tuot-tamaan uusia palveluja monilapsisten perheiden toiveiden mukaan. Työssä käsiteltiin lisäksi mitä tekijöitä lapsiperheiden itse tu...

  2. Revisiting Wasson's Soma: exploring the effects of preparation on the chemistry of Amanita muscaria.

    Science.gov (United States)

    Feeney, Kevin

    2010-12-01

    In 1968 R. Gordon Wasson first proposed his groundbreaking theory identifying Soma, the hallucinogenic sacrament of the Vedas, as the Amanita muscaria mushroom. While Wasson's theory has garnered acclaim, it is not without its faults. One omission in Wasson's theory is his failure to explain how pressing and filtering Soma, as described in the Rig Veda, supports his theory of Soma's identity. Several critics have reasoned that such preparation should be unnecessary if equivalent results can be obtained by consuming the raw plant, as is done with other psychoactive mushrooms. In order to address these specific criticisms over 600 anecdotal accounts of Amanita muscaria inebriation were collected and analyzed to determine the impact of preparation on Amanita muscaria's effects. The findings of this study demonstrated that the effects of Amanita muscaria were related to the type of preparation employed, and that its toxic effects were considerably reduced by preparations that paralleled those described for Soma in the Rig Veda. While unlikely to end debate over the identity of Soma, this study's findings help to solidify the foundation of Wasson's theory, and also to demonstrate the importance of preparation in understanding and uncovering the true identity of Soma.

  3. Pärt: Fratres in sechs Versionen. Festina lente. Summa / C. S.

    Index Scriptorium Estoniae

    C. S.

    1997-01-01

    Uuest heliplaadist "Pärt: Fratres in sechs Versionen. Festina lente. Summa. Cantus in memoriam Benjamin Britten. Orchester der Ungarischen Staatsoper, Tamas Benedek". Naxos CD 8 553 750 (WD:79'06") DDD

  4. Improved detection of soma location and morphology in fluorescence microscopy images of neurons.

    Science.gov (United States)

    Kayasandik, Cihan Bilge; Labate, Demetrio

    2016-12-01

    Automated detection and segmentation of somas in fluorescent images of neurons is a major goal in quantitative studies of neuronal networks, including applications of high-content-screenings where it is required to quantify multiple morphological properties of neurons. Despite recent advances in image processing targeted to neurobiological applications, existing algorithms of soma detection are often unreliable, especially when processing fluorescence image stacks of neuronal cultures. In this paper, we introduce an innovative algorithm for the detection and extraction of somas in fluorescent images of networks of cultured neurons where somas and other structures exist in the same fluorescent channel. Our method relies on a new geometrical descriptor called Directional Ratio and a collection of multiscale orientable filters to quantify the level of local isotropy in an image. To optimize the application of this approach, we introduce a new construction of multiscale anisotropic filters that is implemented by separable convolution. Extensive numerical experiments using 2D and 3D confocal images show that our automated algorithm reliably detects somas, accurately segments them, and separates contiguous ones. We include a detailed comparison with state-of-the-art existing methods to demonstrate that our algorithm is extremely competitive in terms of accuracy, reliability and computational efficiency. Our algorithm will facilitate the development of automated platforms for high content neuron image processing. A Matlab code is released open-source and freely available to the scientific community. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Navigating neurites utilize cellular topography of Schwann cell somas and processes for optimal guidance

    Science.gov (United States)

    Lopez-Fagundo, Cristina; Mitchel, Jennifer A.; Ramchal, Talisha D.; Dingle, Yu-Ting L.; Hoffman-Kim, Diane

    2013-01-01

    The path created by aligned Schwann cells (SCs) after nerve injury underlies peripheral nerve regeneration. We developed geometric bioinspired substrates to extract key information needed for axon guidance by deconstructing the topographical cues presented by SCs. We have previously reported materials that directly replicate SC topography with micro- and nanoscale resolution, but a detailed explanation of the means of directed axon extension on SC topography has not yet been described. Here, using neurite tracing and time-lapse microscopy, we analyzed the SC features that influence axon guidance. Novel poly(dimethylsiloxane) materials, fabricated via photolithography, incorporated bioinspired topographical components with the shapes and sizes of aligned SCs, namely somas and processes, where the length of the processes were varied but the soma geometry and dimensions were kept constant. Rat dorsal root ganglia neurites aligned to all materials presenting bioinspired topography after a 5 days in culture and to bioinspired materials presenting soma and process features after only 17 hours in culture. Key findings of this study were: Neurite response to underlying bioinspired topographical features was time dependent, where at 5 days, neurites aligned most strongly to materials presenting combinations of soma and process features, with higher than average density of either process or soma features; but at 17 hours they aligned more strongly to materials presenting average densities of soma and process features and to materials presenting process features only. These studies elucidate the influence of SC topography on axon guidance in a time-dependent setting and have implications for the optimization of nerve regeneration strategies. PMID:23557939

  6. Resultados da troca de lente intra-ocular de hidrogel opacificada

    Directory of Open Access Journals (Sweden)

    Salera Cristina Moreira

    2004-01-01

    Full Text Available OBJETIVO: Avaliar os resultados da explantação e substituição das lentes intra-oculares (LIO de hidrogel opacificadas. MÉTODOS: Foram analisados retrospectivamente os prontuários de 12 pacientes (15 olhos submetidos à explantação e substituição das lentes intra-oculares de hidrogel opacificadas. RESULTADOS: A opacificação das lentes intra-oculares de hidrogel causou perdas de linhas de visão em 13 olhos (86,7%. A troca das lentes intra-oculares opacificadas promoveu o ganho de linhas de visão em 11 olhos (73,3%. As complicações peroperatórias ocorreram em três olhos (20% e foram as seguintes: perda de óleo de silicone, ruptura total de zônula com perda do saco capsular e ruptura parcial de zônula. Durante a explantação das lentes intra-oculares foi necessária a realização de incisões relaxantes na borda da capsulorrexe anterior em três olhos (20% e em dois olhos (13,3% os hápticos foram cortados sendo retirada somente a zona óptica das lentes intra-oculares. CONCLUSÃO: A cirurgia para explantação e substituição das lentes intra-oculares opacificadas mostrou-se eficaz naqueles pacientes com perdas de linhas de visão (p > 0,05.

  7. Scoring of treatment-related late effects in prostate cancer

    International Nuclear Information System (INIS)

    Livsey, Jacqueline E.; Routledge, Jacqueline; Burns, Meriel; Swindell, Rick; Davidson, Susan E.; Cowan, Richard A.; Logue, John P.; Wylie, James P.

    2002-01-01

    Background and purpose: To assess the correlation between different general and organ specific quality of life and morbidity scoring methods in a cohort of men treated with radical radiotherapy for prostate cancer. Materials and methods: Men who had been treated with radical radiotherapy (50 Gy in 16 fractions over 21 days) for localized prostate cancer more than 3 years previously and who had no evidence of recurrent disease were invited to take part in the study. A total of 101 of 135 invited patients agreed and completed LENT/SOMA, UCLA Prostate Cancer Index, and 36 item RAND Health survey questionnaires. Results: The patients had comparable results with other published series with respect to the UCLA and SF-36 indices. There was significant correlation between the corresponding parts of the UCLA and LENT/SOMA scales (P<0.0005). However, for the same symptoms, a patient tended to score lower (worse) on the UCLA scale in comparison to LENT/SOMA. The relationship between the average LENT/SOMA score and maximum score was also not straightforward with each set of data revealing different information. Conclusions: The LENT/SOMA questions were, in the main, more wide-ranging and informative than the UCLA index. It is helpful to give both the overall and maximum LENT/SOMA scores to most efficiently use all of the data. There may need to be a further LENT/SOMA question to allow both symptoms of tenesmus and faecal urgency to be fully addressed

  8. A univocal definition of the neuronal soma morphology using Gaussian mixture models

    Directory of Open Access Journals (Sweden)

    Sergio eLuengo-Sanchez

    2015-11-01

    Full Text Available The definition of the soma is fuzzy, as there is no clear line demarcating the soma of the labeled neurons and the origin of the dendrites and axon. Thus, the morphometric analysis of the neuronal soma is highly subjective. In this paper, we provide a mathematical definition and an automatic segmentation method to delimit the neuronal soma. We applied this method to the characterization of pyramidal cells, which are the most abundant neurons in the cerebral cortex. Since there are no benchmarks with which to compare the proposed procedure, we validated the goodness of this automatic segmentation method against manual segmentation by experts in neuroanatomy to set up a framework for comparison. We concluded that there were no significant differences between automatically and manually segmented somata, i.e., the proposed procedure segments the neurons more or less as an expert does. It also provides univocal, justifiable and objective cutoffs. Thus, this study is a means of characterizing pyramidal neurons in order to objectively compare the morphometry of the somata of these neurons in different cortical areas and species.

  9. A univocal definition of the neuronal soma morphology using Gaussian mixture models.

    Science.gov (United States)

    Luengo-Sanchez, Sergio; Bielza, Concha; Benavides-Piccione, Ruth; Fernaud-Espinosa, Isabel; DeFelipe, Javier; Larrañaga, Pedro

    2015-01-01

    The definition of the soma is fuzzy, as there is no clear line demarcating the soma of the labeled neurons and the origin of the dendrites and axon. Thus, the morphometric analysis of the neuronal soma is highly subjective. In this paper, we provide a mathematical definition and an automatic segmentation method to delimit the neuronal soma. We applied this method to the characterization of pyramidal cells, which are the most abundant neurons in the cerebral cortex. Since there are no benchmarks with which to compare the proposed procedure, we validated the goodness of this automatic segmentation method against manual segmentation by neuroanatomists to set up a framework for comparison. We concluded that there were no significant differences between automatically and manually segmented somata, i.e., the proposed procedure segments the neurons similarly to how a neuroanatomist does. It also provides univocal, justifiable and objective cutoffs. Thus, this study is a means of characterizing pyramidal neurons in order to objectively compare the morphometry of the somata of these neurons in different cortical areas and species.

  10. Somaæstetisk blik på undervisningsiscenesættelser

    DEFF Research Database (Denmark)

    Justiniano, Birgitte

    Afhandlingen er en undersøgelse af skolers organisering og disses betydning for eleveres mulighed for udvikling af færdigheder, der modsvarer samfunds behov og forventninger. Afhandlingen anlægger et somaæstetisk didaktisk blik på undervisningsiscenesættelser, hvor ønsket er at indfange relatione...

  11. A univocal definition of the neuronal soma morphology using Gaussian mixture models

    Science.gov (United States)

    Luengo-Sanchez, Sergio; Bielza, Concha; Benavides-Piccione, Ruth; Fernaud-Espinosa, Isabel; DeFelipe, Javier; Larrañaga, Pedro

    2015-01-01

    The definition of the soma is fuzzy, as there is no clear line demarcating the soma of the labeled neurons and the origin of the dendrites and axon. Thus, the morphometric analysis of the neuronal soma is highly subjective. In this paper, we provide a mathematical definition and an automatic segmentation method to delimit the neuronal soma. We applied this method to the characterization of pyramidal cells, which are the most abundant neurons in the cerebral cortex. Since there are no benchmarks with which to compare the proposed procedure, we validated the goodness of this automatic segmentation method against manual segmentation by neuroanatomists to set up a framework for comparison. We concluded that there were no significant differences between automatically and manually segmented somata, i.e., the proposed procedure segments the neurons similarly to how a neuroanatomist does. It also provides univocal, justifiable and objective cutoffs. Thus, this study is a means of characterizing pyramidal neurons in order to objectively compare the morphometry of the somata of these neurons in different cortical areas and species. PMID:26578898

  12. Lentes intraoculares fácicas de câmara posterior

    Directory of Open Access Journals (Sweden)

    Mara Barreto Theiss

    Full Text Available Resumo O objetivo deste artigo foi reunir estudos que reportam resultados disponíveis na literatura científica, considerando a previsibilidade, segurança, eficácia, e estabilidade das lentes intraoculares fácicas de câmara posterior. E relatar as complicações documentadas para estas lentes. A revisão criteriosa dos estudos publicados na literatura ate o momento revelam resultado satisfatórios quanto à eficácia, elevada previsibilidade, estabilidade e segurança do implante de lente intraocular de câmara posterior, para correção das miopia, hipermetropia e astigmatismo.

  13. The indissociable unity of psyche and soma: a view from the Paris Psychosomatic School.

    Science.gov (United States)

    Aisenstein, Marilia

    2006-06-01

    Depending on whether or not psyche/soma is seen as singular or dual, one may construct different systems explaining man and the world, life and death. In the author's view, the discoveries of psychoanalysis offer a perfectly cogent and unique solution to the famous mind/body problem. In transferring the duality psyche/soma on to the duality of drives, psychoanalysis places the origin of the thought process in the body. In Beyond the pleasure principle, Freud discusses the drastic effect of a painful somatic illness on the distribution and modalities of the libido. He provides a starting point for the Paris Psychosomatic School's psychoanalytical approach to patients afflicted with somatic illnesses. To illustrate the technical implications of this theory the author relates two clinical cases.

  14. Selfish genetic elements favor the evolution of a distinction between soma and germline.

    Science.gov (United States)

    Johnson, Louise J

    2008-08-01

    Many multicellular organisms have evolved a dedicated germline. This can benefit the whole organism, but its advantages to genetic parasites have not been explored. Here I model the evolutionary success of a selfish element, such as a transposable element or endosymbiont, which is capable of creating or strengthening a germline-soma distinction in a primitively multicellular host, and find that it will always benefit the element to do so. Genes causing germline sequestration can therefore spread in a population even if germline sequestration is maladaptive for the host organism. Costly selfish elements are expected to survive only in sexual populations, so sexual species may experience an additional push toward germline-soma distinction, and hence toward cell differentiation and multicellularity.

  15. Bijdragen aan Hoofdstukken 2-6: Landschapsbiografie Dijkteruglegging Nijmegen-Lent

    NARCIS (Netherlands)

    Heunks, Eckhart

    2016-01-01

    Contributions to a synthesis of landscape archaeological activities carried out in Nijmegen-Lent as part of heritage management by Gemeente Nijmegen during expansion of the city and reconstruction of the Waal river dike and bridges in the past decade. In 2014-2015, Dr. Kim Cohen advised to the

  16. Implante de lente intraocular trifocal difractivo: análisis y resultado de la agudeza visual

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Ibáñez-Hernández

    2017-09-01

    Conclusiones: El implante de un lente intraocular trifocal difractivo es capaz de proporcionar una excelente visión lejana, intermedia y cercana, con escasas aberraciones ópticas, permitiendo una mejor calidad visual útil en actividades desarrolladas a diferentes distancias.

  17. Relationship between subcutaneous blood flow and absorption of lente type insulin

    DEFF Research Database (Denmark)

    Hildebrant, P; Mehlsen, J; Birch, K

    1987-01-01

    To study the relationship between the absorption of intermediate acting insulin and the local subcutaneous blood flow (SBF) 8 diabetic patients were given subcutaneous injections of 125I labeled human lente type insulin and 133Xenon in the abdominal wall. External measurements of the tracer...

  18. Lentes fáquicos como alternativa de tratamiento en el queratocono

    Directory of Open Access Journals (Sweden)

    Raúl Barroso Lorenzo

    Full Text Available El queratocono es una enfermedad degenerativa que se caracteriza por un adelgazamiento progresivo del estroma corneal y la deformidad en forma de cono de la córnea, lo cual provoca astigmatismo irregular y miopía elevada. Se realizó una revisión de artículos publicados referentes al implante de lentes intraoculares fáquicos como alternativa de tratamiento en esta entidad, la cual continúa siendo de difícil manejo en la actualidad. En ametropías con alto componente esférico y cilíndrico, el uso de lente fáquico tórico mostró óptimos resultados visuales. De igual modo el uso de lentes de soporte angular "estira" la córnea y achata el área apical central a través de sus hápticas, con lo que reduce la ectasia corneal y el astigmatismo irregular asimétrico. A su vez, la presencia del lente intraocular entre la pupila y la córnea crea una barrera física que evita la acción de la corriente de humor acuoso contra la córnea y, por consiguiente, hay una estabilización de todos los parámetros de la córnea después de la implantación del lente. La literatura reporta combinación de implantes de lentes fáquicos posterior a anillos intraestromales y crosslinking con un excelente resultado funcional: incrementa en forma importante la agudeza visual sin corrección, mejora las topografías corneales y las aberraciones de alto orden y disminuye la posibilidad de requerir un trasplante de córnea. El uso de lentes fáquicos tóricos en queratoconos estables es una alternativa terapéutica válida como tratamiento de la ametropía que acompaña a esta patología.

  19. Aderência in vitro do Staphylococcus epidermidis e da Pseudomonas alcaligenes em lentes intra-oculares In vitro adherence of Staphylococcus epidermidis and Pseudomonas alcaligenes to intraocular lenses

    Directory of Open Access Journals (Sweden)

    Patrícia Ioschpe Gus

    2006-06-01

    Full Text Available OBJETIVO: Quantificar e comparar a aderência in vitro das bactérias Staphylococcus epidermidis e Pseudomonas alcaligenes em diferentes tipos de lentes intra-oculares (LIOs. MÉTODOS: Quatorze lentes intra-oculares foram usadas no experimento. Quatro de polimetilmetacrilato (PMMA, quatro de silicone, quatro de hidrogel e duas de acrílico. Oito lentes intra-oculares foram colocadas em oito tubos de ensaio contendo 4 ml de suspensão de Pseudomonas alcaligenes, e seis lentes intra-oculares foram colocadas em seis tubos de ensaio contendo 4 ml de suspensão de Staphylococcus epidermidis. A concentração do caldo utilizada para o teste de aderência foi de 10(8 unidades formadoras de colônias por mililitro (CFU/mL que corresponde a 0,5 na escala de McFarland. As lentes foram incubadas a 37° por duas horas. Após, foram removidas dos caldos e enxaguadas em água destilada estéril por duas vezes. As lentes foram cultivadas em placas de ágar-sangue a 35-37° e evaliadas a cada 24h por um período de 72h. Nas amostras que tiveram crescimento bacteriano, foram contadas as colônias utilizando os métodos convencionais de laboratório. Todos os ensaios foram executados em duplicata. RESULTADOS: A aderência do Staphylococcus epidermidis nas lentes de PMMA foi menor se comparada com as de silicone e de hidrogel. A aderência daPseudomonas alcaligenes nas lentes de hidrogel foi menor se comparada com as de silicone, PMMA e acrílico. CONCLUSÃO: Os resultados sugerem que a aderência do Staphylococcus epidermidis e da Pseudomonas alcaligenes nas lentes intra-oculares é influenciada pelo tipo de material da lente e pela espécie do microorganismo. A aderência bacteriana pode ter papel importante na patogenicidade da endoftalmite pós-cirurgia de catarata.PURPOSE: To quantify and compare the in vitro adherence of Staphylococcus epidermidis and Pseudomonas alcaligenes to different intraocular lenses (IOLs. METHODS: Fourteen intraocular lenses were

  20. Opacificación capsular posterior en lentes intraoculares hidrofílicos en comparación con lentes intraoculares hidrofóbicos usando imágenes de Scheimpflug

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    Arturo Olguin Manríquez

    2016-03-01

    Conclusiones: Los resultados de la función visual son comparables entre ambos lentes. La opacificación de la cápsula posterior se vio en menor proporción con el LIO Akreos MI60 cuando se midió por imágenes de Scheimpflug, debido probablemente al diseño del lente. No se demostraron correlación entre ambas pruebas.

  1. Lente de contato de material híbrido em pacientes com ceratocone e astigmatismo miópico composto Hybrid material contact lens in keratoconus and myopic astigmatism patients

    Directory of Open Access Journals (Sweden)

    Fernando Leal

    2007-03-01

    óculos, exceto para a freqüência B (3 cpg, maior nos usuários de óculos. As aberrações de alta ordem analisadas apresentaram diminuição estatisticamente significante, quando comparados os pacientes sem e com uso de lentes de contato, com exceção da aberração esférica e do coma. CONCLUSÃO: A lente de contato de material híbrido, quando utilizada por portadores de ceratocone e astigmatismo miópico composto, propiciaram desempenho visual e conforto satisfatórios, em níveis que não diferiram, das lentes de contato rígidas-gás-permeáveis nos dois grupos de pacientes.PURPOSE: To evaluate comfort and visual performance in relation to two different used contact lens types: hybrid material (HM and rigid-gas-permeable (RGP, in patients with regular myopic astigmatism and with keratoconus. METHODS: A randomized, double masked, prospective study of 22 patients with the diagnosis of myopic astigmatism (8 with myopic astigmatism and 14 with keratoconus was conducted. Fifteen patients were female and 7 were male, and mean age was: 32.13 ± 8.12 years. In one of the eyes a rigid-gas-permeable contact lens was adapted (DK 30, and in the other a hybrid material contact lens was adapted (DK 23. All patients were submitted to the following tests: measurement of comfort level by means of the analogical visual scale, tear break-up time, best corrected visual acuity with the Bailey-Lovie scale adapted for 4 meters, functional acuity contrast test (FACT and wavefront analysis. RESULTS: In relation to comfort, there was no association with the evaluated contact lens type (p=0.350. There was a variation in comfort level during the first 7 days. The visual acuity increased between the 7th and the 15th day of adaptation. Visual acuity stabilized right after this period. The visual acuity did not show differences in relation to the studied lens type. It was verified that there was no difference in the tear break-up time (p=0.989 in relation to the studied lenses type and

  2. From psyche to soma? Changing accounts of antisocial personality disorders in the American Journal of Psychiatry.

    Science.gov (United States)

    Pickersgill, Martyn

    2010-09-01

    The history of psychiatry is often portrayed through the metaphor of a pendulum, the profession swinging back and forth between a concern with psyche and soma. Recent work critiquing the pendulum metaphor, however, suggests that it does not account for the complexity of psychiatry. This article explores the metaphor through an analysis of the changing aetiological accounts of personality disorders associated with antisocial behaviour advanced in the American Journal of Psychiatry from 1950 onwards. It is argued that the social, scientific and economic factors which help shape overarching professional trends in psychiatry only partly structure personality disorder discourse. If the pendulum swings, therefore, not all psychiatrists move with it.

  3. SOMA: A Proposed Framework for Trend Mining in Large UK Diabetic Retinopathy Temporal Databases

    Science.gov (United States)

    Somaraki, Vassiliki; Harding, Simon; Broadbent, Deborah; Coenen, Frans

    In this paper, we present SOMA, a new trend mining framework; and Aretaeus, the associated trend mining algorithm. The proposed framework is able to detect different kinds of trends within longitudinal datasets. The prototype trends are defined mathematically so that they can be mapped onto the temporal patterns. Trends are defined and generated in terms of the frequency of occurrence of pattern changes over time. To evaluate the proposed framework the process was applied to a large collection of medical records, forming part of the diabetic retinopathy screening programme at the Royal Liverpool University Hospital.

  4. Estudo comparativo do desempenho óptico de diversas lentes intra-oculares (LIO) multifocais

    OpenAIRE

    Antunes, Telma Nicole Nogueira

    2012-01-01

    A cirurgia da catarata tem vindo a evoluir ao longo dos anos, tendo sido realizado o primeiro implante de uma lente intra-ocular em 1949. Desde então, várias técnicas foram utilizadas e descontinuadas devido a insucessos. Actualmente é utilizada a técnica de facoemulsificação. Tal como a técnica cirúrgica a lente implantada também tem vindo a evoluir, tanto a nível do material como a nível de design. Com as evoluções, tanto a nível de técnica cirúrgica como a nível de forma e material das len...

  5. Diabetes mellitus y lentes de contacto Diabetes mellitus related to use of contact lenses

    Directory of Open Access Journals (Sweden)

    Beatriz Zozaya Aldana

    2009-04-01

    Full Text Available Cada día aumenta el número de diabéticos diagnosticados que demandan como método de compensación para los defectos de refracción las lentes de contacto. Debido a la escasa información que se tiene sobre el tema, dedicamos nuestro trabajo a realizar una revisión sobre la relación de estos dos temas: lentes de contacto y diabetes, con el justo ánimo de brindar una atención más completa a nuestros pacientes.Every day increases the figure of diagnosed diabetic patients requiring a compensatory method for refraction defects the use of contact lenses. Due to the non-available information on this matter, this paper is aimed to make a review on relation between these two topics: contact lenses and diabetes to offer a more complete care to our patients.

  6. 12 CFR 7.1003 - Money lent at banking offices or at other than banking offices.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Money lent at banking offices or at other than banking offices. 7.1003 Section 7.1003 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE... without violating 12 U.S.C. 36, 12 U.S.C. 81 and 12 CFR 5.30, provided that a third party is used to...

  7. Infiltrados corneales asociados al uso de lentes de contacto Corneal infiltrates associated with contact lens wear

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    Vivian Padrón Álvarez

    2001-12-01

    Full Text Available Se estudiaron 15 pacientes que usan lentes de contacto rígidas, permeables al gas (LCRPG y lentes de contacto blandas (LCB que presentaron infiltrados corneales. Se realizó estudio microbiológico de las lesiones y seguimiento clínico de estos casos. En 3 de los casos estudiados el cultivo fue positivo a estafilococo aureus, el resto de los estudios microbiológicos fueron negativos. Todos los pacientes respondieron rápidamente al retirar la lente de contacto y al tratamiento con antibióticos tópicos y ninguno tuvo afectación permanente de la agudeza visual. El diagnóstico exacto y el manejo apropiado de los infiltrados corneales en pacientes que usan lentes de contacto es de gran importancia por la posibilidad de infección o de secuela visual permanente.15 patients wearing gas permeable rigid contact lenses (GPRCL and soft contanct lenses (SCL that presented corneal infiltrates were studied. A microbiological study of the injuries and a clinical follow-up of these cases were conducted. In 3 of the studied cases the culture was positive to Staphyloccocus aureus. The rest of the mircobiological studies were negative. All the patients responded rapidly to the contact lens removal and to the treatment with topical antibiotics. None of them had permanent affection of visual acuity. The accurate diagnosis and the appropiate management of the corneal infiltrates in patients wearing contact lenses is very important due to the possibility of infection or of permanent visual sequela.

  8. Avaliação da qualidade de vida em pacientes submetidos à cirurgia de catarata, com implantes de lentes monofocais bifocais e multifocais

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    Beogival Wagner Lucas Santos

    2014-04-01

    Full Text Available Objetivo: Fornecer uma avaliação objetiva e subjetiva da qualidade de vida e o nível de satisfação de pacientes que se submeteram à cirurgia de catarata, com implante de lentes bifocais, multifocais e monofocais. Métodos: Lentes bifocais foram implantadas em 72 pacientes; lentes multifocais asférica em 16 pacientes; lentes multifocais apodizada em 20 pacientes e lentes monofocais em 63 pacientes. Foi aplicado um questionário de 47 perguntas cujos resultados foram avaliados e analisados. Resultados: O nível de satisfação dos pacientes implantados com lentes bifocais e multifocais foi significantemente mais alto do que aqueles com lentes monofocais (teste Kruskal-Wallis p<0,01, seguido do teste Dunn, p<0,05. Quanto à comparação de lentes monofocais com lentes bifocais e multifocais, a visão para perto sem correção foi consideravelmente mais baixa em pacientes com lentes monofocais (teste Z, p<0,001. Os pacientes com lentes monofocais sem correção apresentaram uma menor capacidade de ler jornais ou livros e no que diz respeito a trabalhos manuais do que aqueles com lentes bifocais e multifocais (teste Z, p<0,001. Conclusão: Os resultados deste estudo mostram que os pacientes que receberam as lentes bifocais e multifocais tiveram uma melhora notável em sua acuidade visual para perto, estando satisfeitos com sua visão geral, sem óculos. A satisfação foi atribuída ao fato de conseguirem ler livros e jornais, preencher cheques, preencher formulários, praticar esportes, se barbear ou se maquiar sem correção.

  9. CT, MRI and PET image fusion using the ProSoma 3D simulation software

    International Nuclear Information System (INIS)

    Dalah, E.; Bradley, D.A.; Nisbet, A.; Reise, S.

    2008-01-01

    Full text: Multi-modality imaging is involved in almost all oncology applications focusing on the extent of disease and target volume delineation. Commercial image fusion software packages are becoming available but require comprehensive evaluation to ensure reliability of fusion and the underpinning registration algorithm particularly for radiotherapy. The present work seeks to assess such accuracy for a number of available registration methods provided by the commercial package ProSoma. A NEMA body phantom was used in evaluating CT, MR and PET images. In addition, discussion is provided concerning the choice and geometry of fiducial markers in phantom studies and the effect of window-level on target size, in particular in regard to the application of multi modality imaging in treatment planning. In general, the accuracy of fusion of multi-modality images was within 0.5-1.5 mm of actual feature diameters and < 2 ml volume of actual values, particularly in CT images. (author)

  10. Ion channel density regulates switches between regular and fast spiking in soma but not in axons.

    Directory of Open Access Journals (Sweden)

    Hugo Zeberg

    2010-04-01

    Full Text Available The threshold firing frequency of a neuron is a characterizing feature of its dynamical behaviour, in turn determining its role in the oscillatory activity of the brain. Two main types of dynamics have been identified in brain neurons. Type 1 dynamics (regular spiking shows a continuous relationship between frequency and stimulation current (f-I(stim and, thus, an arbitrarily low frequency at threshold current; Type 2 (fast spiking shows a discontinuous f-I(stim relationship and a minimum threshold frequency. In a previous study of a hippocampal neuron model, we demonstrated that its dynamics could be of both Type 1 and Type 2, depending on ion channel density. In the present study we analyse the effect of varying channel density on threshold firing frequency on two well-studied axon membranes, namely the frog myelinated axon and the squid giant axon. Moreover, we analyse the hippocampal neuron model in more detail. The models are all based on voltage-clamp studies, thus comprising experimentally measurable parameters. The choice of analysing effects of channel density modifications is due to their physiological and pharmacological relevance. We show, using bifurcation analysis, that both axon models display exclusively Type 2 dynamics, independently of ion channel density. Nevertheless, both models have a region in the channel-density plane characterized by an N-shaped steady-state current-voltage relationship (a prerequisite for Type 1 dynamics and associated with this type of dynamics in the hippocampal model. In summary, our results suggest that the hippocampal soma and the two axon membranes represent two distinct kinds of membranes; membranes with a channel-density dependent switching between Type 1 and 2 dynamics, and membranes with a channel-density independent dynamics. The difference between the two membrane types suggests functional differences, compatible with a more flexible role of the soma membrane than that of the axon membrane.

  11. Adaptação de lente de contato gelatinosa especial para ceratocone Keratoconus special soft contact lens fitting

    Directory of Open Access Journals (Sweden)

    Ester Sakae Yamazaki

    2006-08-01

    Full Text Available OBJETIVO: Relatar a experiência inicial com o uso de lentes de contato gelatinosas especiais para ceratocone. MÉTODOS: Estudo retrospectivo de 80 olhos de 66 pacientes usuários de lentes de contato gelatinosas especial para ceratocone, no Setor de Lentes de Contato da UNIFESP e em clínicas particulares. Os pacientes foram classificados de acordo com o grau de gravidade da doença pela avaliação ceratométrica. Foram coletados os seguintes dados: idade, sexo, diagnóstico, ceratometria, acuidade visual com a lente, equivalente esférico (ES, curvatura da lente e indicação para o seu uso. RESULTADOS: Foram estudados 80 olhos de 66 pacientes usuários de lente gelatinosa para ceratocone. A média de idade foi de 29 anos, sendo 51,5% homens e 48,5% de mulheres. De acordo com os grupos: incipiente: 15,0%, moderado: 53,7%, avançado: 26,3%, grave: 5,0%. A maioria dos olhos estudados (91,25% apresentou acuidade visual melhor que 20/40 com a lente. Foram adaptadas 58% lentes de poder esférico (média de -5,45 dioptrias e 41% lentes com grau esferocilíndrico (variando de -0,50 a -5,00 dioptrias cilíndricas. A curva esférica mais utilizada foi de 7,6 mm (61% dos olhos. As principais razões para a escolha e adaptação desta lente foram devido à intolerância e ao padrão de adaptação insatisfatório com outras lentes. CONCLUSÃO: A lente gelatinosa para ceratocone pode ser usada em casos de difícil adaptação, como uma opção para melhorar o conforto e possibilitar a reabilitação visual em pacientes que não obtiveram alternativas a não ser algum procedimento cirúrgico.PURPOSE: To evaluate the fitting and use of a soft contact lens in keratoconic patients. METHODS: Retrospective study on 80 eyes of 66 patients, fitted with a special soft contact lens for keratoconus, at the Contact Lens Section of UNIFESP and private clinics. Keratoconus was classified according to degrees of disease severity by keratometric pattern. Age, gender

  12. Cálculo del poder de la lente intraocular mediante biometría ultrasónica

    Directory of Open Access Journals (Sweden)

    Yileika Elías García

    Full Text Available Objetivo: caracterizar el comportamiento del cálculo de la lente intraocular mediante biometría ultrasónica. Métodos: se realizó un estudio descriptivo y prospectivo, con un grupo de pacientes atendidos por el Servicio de Catarata del Centro Oftalmológico «Enrique Cabrera», que recibieron tratamiento quirúrgico por catarata con implante de lente intraocular, mediante técnica de Blumenthal. La muestra se conformó con 160 ojos y se estudiaron las variables: sorpresa refractiva, edad, longitud axial y promedio queratométrico según resultado refractivo, poder dióptrico de la lente y componente esférico según edad. Resultados: como resultados más sobresalientes, se obtuvo que el 78,7 % no presentó error en el cálculo de la lente, la mayoría de los pacientes tenían 60 años y más, predominó el rango de longitud axial entre 22 y 24,4 (67,5 %, el promedio queratométrico de 43 a 44,99 (64,3 %, el poder dióptrico del lente de + 20 a + 23 dioptrías (48,2 % y el componente esférico entre 0,00 y +/-1,00 dioptrías (78,8%. Conclusiones: se considera que la biometría ultrasónica resulta adecuada para el cálculo correcto del lente.

  13. Contact lens-associated microbial keratitis Ceratites microbianas relacionadas a lente de contato

    Directory of Open Access Journals (Sweden)

    Aline Silveira Moriyama

    2008-12-01

    Full Text Available PURPOSE: Contact lens-associated microbial keratitis is a severe condition with sight-threatening potential and increasing incidence. Information regarding the etiological agents is essential in guiding management and may vary geographically. The aim of this study was to analyze the microbiological results of corneal scrapings collected from patients presenting with contact lens-associated microbial keratitis. METHODS: Retrospective analysis of the records of all patients who were clinically diagnosed with contact lens-associated microbial keratitis and had corneal scrapings sent to the Laboratory of Ocular Microbiology, UNIFESP/EPM during a 5-year period from January 2002 to December 2007. RESULTS: The etiological agent was identified in 239 patients. Bacterial isolates accounted for 166 (69.46% cases, Acanthamoeba for 95 (39.75% cases and fungi for 4 (1.67% cases. Among the bacterial infections, coagulase-negative Staphylococcus was demonstrated in 74 cases, while Pseudomonas spp was found in 32 patients. All coagulase negative Staphylococcus and Pseudomonas were susceptible to ciprofloxacin and ofloxacin. Resistance to gentamicin was documented in a single case of Pseudomonas. Fourth-generation flouoroquinolone resistance was not observed among Pseudomonas cases. CONCLUSION: Coagulase-negative Staphylococcus was the most frequent isolate, and such data must be considered when determining empiric treatment. Second-generation fluoroquinolones ciprofloxacin and ofloxacin and fourth-generation fluoroquinolones moxifloxacin and gatifloxacin showed a good antibacterial profile and therefore could be good options for initial management.OBJETIVO: A ceratite microbiana associada ao uso de lente de contato é uma condição clínica grave, com risco de perda visual e cuja incidência vem aumentando progressivamente. Os principais agentes etiológicos podem variar geograficamente e informações referentes aos agentes causais são essenciais para

  14. Soma, food of the immortals according to the Bower Manuscript (Kashmir, 6th century A.D.).

    Science.gov (United States)

    Leonti, Marco; Casu, Laura

    2014-08-08

    Food is medicine and vice versa. In Hindu and Ayurvedic medicine, and among human cultures of the Indian subcontinent in general, the perception of the food-medicine continuum is especially well established. The preparation of the exhilarating, gold-coloured Soma, Amrita or Ambrosia, the elixir and food of the 'immortals'-the Hindu pantheon-by the ancient Indo-Aryans, is described in the Rigveda in poetic hymns. Different theories regarding the botanical identity of Soma circulate, but no pharmacologically and historically convincing theory exists to date. We intend to contribute to the botanical, chemical and pharmacological characterisation of Soma through an analysis of two historical Amrita recipes recorded in the Bower Manuscript. The recipes are referred therein as panaceas (clarified butter) and also as a medicine to treat nervous diseases (oil), while no exhilarating properties are mentioned. Notwithstanding this, we hypothesise, that these recipes are related to the ca. 1800 years older Rigvedic Soma. We suppose that the psychoactive Soma ingredient(s) are among the components, possibly in smaller proportions, of the Amrita recipes preserved in the Bower Manuscript. The Bower Manuscript is a medical treatise recorded in the 6th century A.D. in Sanskrit on birch bark leaves, probably by Buddhist monks, and unearthed towards the end of the 19th century in Chinese Turkestan. We analysed two Amrita recipes from the Bower Manuscript, which was translated by Rudolf Hoernle into English during the early 20th century. A database search with the updated Latin binomials of the herbal ingredients was used to gather quantitative phytochemical and pharmacological information. Together, both Amrita recipes contain around 100 herbal ingredients. Psychoactive alkaloid containing species still important in Ayurvedic, Chinese and Thai medicine and mentioned in the recipe for 'Amrita-Prâsa clarified butter' and 'Amrita Oil' are: Tinospora cordifolia (Amrita, Guduchi), three

  15. Desempenho visual dos pacientes pseudofácicos com diferentes lentes intraoculares

    Directory of Open Access Journals (Sweden)

    Wilson Takashi Hida

    2013-10-01

    Full Text Available OBJETIVO: Comparar a performance visual dos pacientes submetidos ao implante das lentes intraoculares multifocais difrativas Tecnis® MF ZM900, Acrysof® Restor® SN60D3, Acrysof® SN60WF e Acrysof® SN60AT. MÉTODOS: Estudo prospectivo comparativo, não randomizado, que incluiu 142 olhos de 71 pacientes com catarata, provenientes do ambulatório de oftalmologia do HC-FMUSP. A avaliação oftalmológica contou com medida da acuidade visual para longa, intermediária e curta distância, sem correção e com a melhor correção óptica, teste de sensibilidade ao contraste, pupilometria e análise de frente de onda por meio do aberrômetro. Todos os exames foram realizados com seis meses de pós-operatório. RESULTADOS: A média de idade dos pacientes foi de 60,7±6,6 anos no grupo Tecnis, 63,1±4,4 anos no grupo Restor e 63,7±4,2 anos no grupo monofocal (SN60AT no olho contralateral SN60WF. A acuidade visual para perto não corrigida e corrigida para longe foi estatisticamente superior nos grupos multifocal Restor e multifocal Tecnis em comparação ao grupo monofocal SN60AT/SN60WF (p<0,001. Não houve diferença estatística entre os grupos na comparação da acuidade visual para longe (p=0,56. A sensibilidade ao contraste fotópica monocular foi estatisticamente inferior nos grupos Restor e Tecnis (p<0,001. A SN60AT apresentou maior aberração esférica comparada a todas as outras lentes (p<0,001. A Tecnis se mostrou com menores valores médios de aberrações esféricas na comparação com a Restor (p<0.001. CONCLUSÃO: A Restor e Tecnis apresentaram melhor acuidade visual para perto do que o grupo monofocal SN60AT/SN60WF. Todas as lentes intraoculares promoveram boa visão para longe. O grupo da Tecnis apresentou melhor sensibilidade de contraste, menos aberrações ópticas e melhor visão intermediária que o grupo Restor.

  16. Lentes fácicas de câmara anterior

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    Walton Nosé

    2012-08-01

    Full Text Available Os implantes em olhos fácicos apresentam-se como uma opção para a correção de altas ametropias. De acordo com sua localização podem ser classificados como de câmara anterior ou posterior, sendo que os primeiros subdividem-se em fixação iriana ou de suporte angular. Além da correção da miopia, as lentes de fixação iriana apresentam modelos para hipermétropes e astigmatas. Várias modificações no desenho das lentes foram propostas nas últimas décadas com a finalidade de reduzir complicações tardias, como a perda endotelial progressiva. Cuidados no intraoperatório devem ser tomados de forma a diminuir a perda endotelial aguda relacionada ao trauma. Avanços nos métodos de triagem pré-operatória também melhoraram a segurança do procedimento. A estimativa do poder dióptrico é baseada nos cálculos de Van der Heijde, sendo dependente da profundidade de câmara anterior, do equivalente esférico da refração e da média ceratométrica. Resultados a longo prazo demonstram a eficácia, previsibilidade e segurança do procedimento. Dependendo do modelo, além da possibilidade de perda endotelial, outras possíveis complicações incluem: irite, dispersão pigmentar, atrofia de íris, ovalização pupilar, rotação, descentração ou deslocamento da lente, hipertensão ocular e bloqueio pupilar. Modelos dobráveis atualmente disponíveis vêm apresentado resultados bastante promissores com redução da taxa de complicações.

  17. Abordagens Somáticas do Corpo na Dança

    Directory of Open Access Journals (Sweden)

    Marcilio Souza

    2014-12-01

    Full Text Available Entende-se a Educação Somática como um campo interdisciplinar que se interessa pela consciência do corpo e seu movimento e que se propõe a uma descoberta pessoal de seus próprios movimentos, de suas próprias sensações. O presente artigo objetiva propor uma reflexão por meio de notas sobre o conceito de Educação Somática, Soma e Corpo, bem como destacar duas abordagens somáticas que são incorporadas nas práticas da temática em voga como caminhos possíveis para pensar o campo em estudo na dança. Parte de uma abordagem fenomenológica pautada nos estudos de Merleau-Ponty (1999, tomando como técnica de pesquisa a descrição merleaupontyana.

  18. Lentes progressivas: análise dos campos intermediário e de perto por deflexometria

    Directory of Open Access Journals (Sweden)

    Celso Marcelo Cunha

    2013-02-01

    Full Text Available OBJETIVO: Avaliar por deflexometria as diferentes regiões das lentes progressivas e determinar as áreas dos campos de visão intermediário e de perto. MÉTODOS: Foram incluídas vinte e duas lentes progressivas com poder +1,00 DE para longe e duas adições diferentes (adição 1,00 e 2,00, 11 de cada. Mediram-se as áreas dos campos intermediário e de perto entre as isoastigmáticas de 0,5 DC. RESULTADOS: Encontraram-se diferenças significativas entre as áreas dos campos intermediário e de perto das lentes estudadas. Entre a área do campo intermediário e a adição observou-se correlação inversa; entre a área do campo intermediário e a extensão vertical do corredor encontrou-se correlação direta. CONCLUSÃO: Com esses dados permitem-se recomendar as lentes de acordo com o campo de maior necessidade visual de cada usuário.

  19. Estrutura de populações de Rhodnius neglectus Lent e Psammolestes tertius Lent & Jurberg (Hemiptera, Reduviidae em ninhos de pássaros (Furnariidae presentes na palmeira Mauritia flexuosa no Distrito Federal, Brasil Population structure of Rhodnius neglectus Lent and Psammolestes tertius Lent & Jurberg (Hemiptera, Reduviidae in bird nests (Furnariidae on Mauritia flexuosa palm trees in Federal District of Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo Gurgel-Gonçalves

    2007-03-01

    Full Text Available Rhodnius neglectus Lent, 1954 {Rn}e Psammolestes tertius Lent & Jurberg, 1965 {Pt} são triatomíneos que ocorrem em ninhos de aves, principalmente da família Furnariidae. O ciclo biológico dessas espécies é conhecido em condições de laboratório, sendo poucos estudos em ecótopos silvestres. Para analisar a infestação e estrutura de populações de Rn e Pt em ninhos de aves presentes na palmeira Mauritia flexuosa Linnaeus, em duas estações climáticas do Brasil Central, foram amostradas 41 palmeiras com evidências de nidificação de Phacellodomus ruber Vieillot, 1817 (22 na estação chuvosa e 19 na estação seca em quatro áreas do Distrito Federal. Os insetos foram capturados usando-se coleta manual na copa da palmeira, identificados morfologicamente, separados por sexo e estádio ninfal. Fezes e glândulas salivares de Rn foram examinadas para verificar infecção por Trypanosoma cruzi Chagas, 1909 e/ou T. rangeli Tejera, 1920. Trinta e cinco palmeiras com ninhos de P. ruber estavam infestadas por Rn (85% e 22 por Pt (53%. 442 indivíduos foram coletados na estação seca (200 Rn e 242 Pt e 267 na estação chuvosa (136 Rn e 131 Pt. O único fator relacionado significativamente com a densidade de triatomíneos nas palmeiras foi a área. A estrutura etária das populações mostrou: a maior abundância de adultos nas populações de Pt, b maior abundância de machos em ambas as espécies e c presença de fêmeas ovipondo em ambas as estações. Nenhum dos 177 triatomíneos examinados estava infectado por T. cruzi ou T. rangeli. A estrutura etária das populações de Rn e Pt não diferiu significativamente entre as estações amostradas, indicando ausência de marcada sazonalidade para essas espécies.Rhodnius neglectus Lent, 1954 {Rn}and Psammolestes tertius Lent & Jurberg, 1965 {Pt} are triatomines that occur in bird nests, mainly furnarid nests. Their biological cycles are known in laboratory conditions and few studies were

  20. Luz y gravedad (Reflexiones geométricas sobre cáusticas y lentes gravitacionales

    Directory of Open Access Journals (Sweden)

    Elena Ortiz García

    2011-04-01

    Full Text Available Cuando los rayos de luz iluminan una taza de café en una tardesoleada, podemos observar la curva que más brilla sobre la superficie del líquido. Quizá sea ésta una oportunidad para plantearse el siguiente experimento mental: ¿cómo juegan los rayos de luz al reflejarse en diferentes “tazas” geométricas? Esta comunicación pretende proseguir esta discusión con algunas consideraciones sencillas que nos sitúen ante el fenómeno de las lentes gravitacionales, allí donde los efectos de la gravedad afectan, incluso, a la manera de propagarse de la luz, mostrando un sistema dinámico idealizado que resulta, a la vez, sencilloy (matemáticamente caótico.

  1. CURED I - LENT. Late effects of cancer treatment on normal tissues

    International Nuclear Information System (INIS)

    Rubin, P.; Okunieff, P.; Constine, L.S.; Rochester Univ. School of Medicine and Dentistry, Rochester, NY; Marks, L.B.

    2008-01-01

    The search for the most favorable therapeutic ratio - at which ablation of cancer is achieved while normal tissues are conserved - has been modern radiation oncology's equivalent of the quest for the Holy Grail. Our awareness of the late effects of radiation grew during the past century as new modalities were introduced. Heightened normal tissue reactions accompanied the higher rates of cancer ablation achieved by escalation of radiation doses, accelerated fractionated radiotherapy, and aggressive concurrent chemotherapy and radiation regimens. This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006. Written by experts in the field, it addresses a number of critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that it will assist the reader in understanding how to prevent and treat the long-term side-effects of irradiation. (orig.)

  2. Lente intra-ocular multifocal difrativa apodizada: resultados Diffractive apodized multifocal intraocular lens: results

    Directory of Open Access Journals (Sweden)

    Virgilio Centurion

    2007-12-01

    Full Text Available OBJETIVO: Mostrar os resultados visuais e refracionais com lente intra-ocular multifocal difrativa apodizada. MÉTODOS: Estudo de 100 olhos de 50 pacientes com catarata, submetidos à facoemulsificação com implante bilateral de lente intra-ocular (LIO multifocal difrativa apodizada. Foi avaliada a acuidade visual binocular sem e com correção para longe e perto, a previsibilidade refracional e a freqüência de uso de óculos. RESULTADOS: A acuidade visual sem correção para longe foi de e " 20/30 em 97,56% dos olhos operados e e" J2 em 100%, sendo que 82% dos pacientes nunca usam óculos e 16% usam de forma esporádica. CONCLUSÃO: A LIO multifocal difrativa apodizada mostrou ser uma opção previsível, reproduzível e segura na correção dos vícios de refração para longe e perto durante a cirurgia da catarata, permitindo elevado índice de independência ao uso de óculos.OBJECTIVE: To show visual and refraction results using multifocal diffractive apodized intraocular lens. METHODS: The study of 100 eyes of 50 patients with cataract, submitted to phacoemulsification with bilateral implant of multifocal diffractive apodized intraocular lens (IOL. Binocular visual acuity was evaluated with and without correction for near and distance, and refraction previsibility and frequency of wearing glasses. RESULTS: Visual acuity without correction for distance was e" 20/30 in 97.56% of eyes operated on and e" J2 in 100%, of these 82% of patients never wear glasses and 16% wear glasses sporadically. CONCLUSION: Multifocal diffractive apodized IOL proved to be a foreseeable option, reproducible and safe in the correction of refraction errors for distance and near during cataract surgery, enabling a high rate of independence from the use of glasses.

  3. Medindo o poder refrativo de lentes de contato gelatinosas personalizadas Measuring the refractive power of customized soft contact lenses

    Directory of Open Access Journals (Sweden)

    Luis Alberto Vieira de Carvalho

    2007-02-01

    Full Text Available OBJETIVO: Lentes de contato gelatinosas com curvas-base esféricas têm sido usadas há anos. O cálculo do poder refrativo de lentes deste tipo é fácil, bastando utilizarmos a equação do fabricante de lentes para lentes espessas. No entanto, para projetos de lentes de contato personalizadas, não há ainda métodos confiáveis para medida das aberrações ópticas de ordem mais alta. Esse trabalho foi desenvolvido no laboratório do Centro de Ciências da Visão (Center for Visual Science da Universidade de Rochester, Nova York, com aparelho óptico que permite realizar medidas precisas de aberrações de ordem baixa e alta de lentes de contato gelatinosas personalizadas. Este é um passo essencial na verificação e obtenção de lentes de contato personalizadas de qualidade, e o instrumento desenvolvido na Universidade de Rochester permite verificar a qualidade de fabricação destas lentes. MÉTODOS: Um aparelho óptico de bancada foi montado em laboratório. Este aparelho consiste de uma célula úmida onde as lentes de contato são depositadas. Consiste também de uma série de lentes e espelhos e um sensor de frente-de-onda de Hartmann-Shack. As lentes de contato personalizadas utilizadas neste projeto foram fabricadas pela empresa Bausch & Lomb. Das dezenas de lentes de contato mensuradas no aparelho, restringimos aqui a apresentar os resultados de uma lente personalizada para ceratocone. RESULTADOS: O erro quadrático médio (EQM do instrumento foi de 0,04 micrômetro, sendo que o EQM das aberrações induzidas na lente está entre 4 e 6 micrômetros, ou seja, a precisão do aparelho está em torno de 1%. Este valor é mais do que suficiente para medidas precisas destes tipos de lentes de contato, algo até então inviável utilizando-se os sensores ou aparelhos convencionais de aberrometria. CONCLUSÃO: Com o instrumento desenvolvido neste trabalho foi possível realizar medidas precisas de aberrações de alta ordem. Esta

  4. The SOFIA Massive (SOMA) Star Formation Survey. I. Overview and First Results

    Energy Technology Data Exchange (ETDEWEB)

    De Buizer, James M.; Shuping, Ralph [SOFIA-USRA, NASA Ames Research Center, MS 232-12, Moffett Field, CA 94035 (United States); Liu, Mengyao; Tan, Jonathan C.; Staff, Jan E.; Tanaka, Kei E. I. [Department of Astronomy, University of Florida, Gainesville, FL 32611 (United States); Zhang, Yichen [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); Beltrán, Maria T. [INAF-Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy); Whitney, Barbara [Department of Astronomy, University of Wisconsin-Madison, 475 N. Charter St, Madison, WI 53706 (United States)

    2017-07-01

    We present an overview and first results of the Stratospheric Observatory For Infrared Astronomy Massive (SOMA) Star Formation Survey, which is using the FORCAST instrument to image massive protostars from ∼10 to 40 μ m. These wavelengths trace thermal emission from warm dust, which in Core Accretion models mainly emerges from the inner regions of protostellar outflow cavities. Dust in dense core envelopes also imprints characteristic extinction patterns at these wavelengths, causing intensity peaks to shift along the outflow axis and profiles to become more symmetric at longer wavelengths. We present observational results for the first eight protostars in the survey, i.e., multiwavelength images, including some ancillary ground-based mid-infrared (MIR) observations and archival Spitzer and Herschel data. These images generally show extended MIR/FIR emission along directions consistent with those of known outflows and with shorter wavelength peak flux positions displaced from the protostar along the blueshifted, near-facing sides, thus confirming qualitative predictions of Core Accretion models. We then compile spectral energy distributions and use these to derive protostellar properties by fitting theoretical radiative transfer models. Zhang and Tan models, based on the Turbulent Core Model of McKee and Tan, imply the sources have protostellar masses m {sub *} ∼ 10–50 M {sub ⊙} accreting at ∼10{sup −4}–10{sup −3} M {sub ⊙} yr{sup −1} inside cores of initial masses M {sub c} ∼ 30–500 M {sub ⊙} embedded in clumps with mass surface densities Σ{sub cl} ∼ 0.1–3 g cm{sup −2}. Fitting the Robitaille et al. models typically leads to slightly higher protostellar masses, but with disk accretion rates ∼100× smaller. We discuss reasons for these differences and overall implications of these first survey results for massive star formation theories.

  5. Guía Clínica para la Adaptación de Lentes de Contacto Multifocales Tóricas Hidrofílicas

    OpenAIRE

    García Valencia, Lidia

    2015-01-01

    Elaboración de una guía clínica para la adaptación de lentes de contacto multifocales tóricas, basada en la bibliografía existente sobre ese tipo de lentes de contacto y un caso clínico utilizado para faciltar su comprensión. Grado en Óptica y Optometría

  6. Reorganization of Students Disability Support Unit in Bülent Ecevit University

    Directory of Open Access Journals (Sweden)

    Hakan KALYON

    2012-01-01

    Full Text Available Universities are the centers where science and knowledge can be produced and shared freely. In these centers, it is probable that disabled people can be in the audience and benefit from these training and education activities. Therefore, removing inequalities defined as “inequitable differences of individuals not caused by personal characteristics” and solving problems in accessing information and education is an indispensible target for our country.The highest step among the needs of the human beings is self-perform. Especially, in the social order of 21st century, the disabled people who aim to meet the expectations of life should be supported allover.Turkey has a young and dynamic population; there is a significant increase in the number of the disabled students who reach and graduate from higher education in 2000s. In 2000, 97 disabled students graduated from universities and this number reached 410 in 2008 and 1090 in 2009. Number of disabled students in the Universities of Turkey reached 3584 in 2011.One of the most important examples in the process of legislative changes about the education of disabled people is the “Institutions of Higher Education Disabled People Consultation and Coordination Regulation.” The purpose of the regulation is to take steps in order to ease the education lives of the disabled people in higher education. In the context of applicable law, the unit of disabled students is restructured at Bülent Ecevit University.

  7. Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma.

    Directory of Open Access Journals (Sweden)

    Elaine M Morazzani

    2012-01-01

    Full Text Available The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral response directed by small interfering RNAs (siRNAs is important in modulating the pathogenesis of alphavirus infections in the mosquito. However, we report here that infection of mosquitoes with an alphavirus also triggers the production of another class of virus-derived small RNAs that exhibit many similarities to ping-pong-dependent piwi-interacting RNAs (piRNAs. However, unlike ping-pong-dependent piRNAs that have been described previously from repetitive elements or piRNA clusters, our work suggests production in the soma. We also present evidence that suggests virus-derived piRNA-like small RNAs are capable of modulating the pathogenesis of alphavirus infections in dicer-2 null mutant mosquito cell lines defective in viral siRNA production. Overall, our results suggest that a non-canonical piRNA pathway is present in the soma of vector mosquitoes and may be acting redundantly to the siRNA pathway to target alphavirus replication.

  8. Evaluation of the Effects of Nationwide Conservation Voltage Reduction on Peak-Load Shaving Using SOMAS Data

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    Soon-Ryul Nam

    2013-12-01

    Full Text Available In this paper we propose a new method to evaluate the effects of nationwide conservation voltage reduction (CVR on peak-load shaving, using substation operating results management system (SOMAS data. Its evaluation is based on a national CVR factor, which is defined as the weighted average of CVR factors associated with all transformer banks and weighting coefficients are determined by the reconstructed loads corresponding to each transformer bank. To make use of the data resulting from nationwide CVR without installing additional measuring devices, we adopt a linearized static-load model with a linearizing parameter. SOMAS data are used to evaluate the effects of nationwide CVR on peak-load shaving in the Korean power system. Evaluation results show that the national CVR factor of the Korean power system has small values in the summer season and large values in the winter season. This means that the effect of nationwide CVR on peak-load shaving in the Korean power system presents stronger benefits during winter months.

  9. Fission ionisation chamber for the measurement of low fluxes of slow neutrons; Chambre d'ionisation a fission pour la mesure des faibles flux de neutrons lents

    Energy Technology Data Exchange (ETDEWEB)

    Weill, J; Duchene, J P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    The ionisation chamber described is designed for the measurement of slow neutron fluxes of average or low intensity, in the presence, eventually, of very high gamma fluxes. The capture of a slow neutron by a fissile material, in this case {sup 235}U, gives rise to fission fragments, high-energy particles which ionise the gas contained in the chamber. The neutrons are detected by virtue of the potential pulses, on the collecting electrode of the chamber, deriving from the collection of the ions produced by the fission fragments. The pulses are counted by means of a measuring system consisting of a preamplifier, a 2 Mc amplifier, a discriminator and an electronic scale with numerator or integrator. The general characteristics are as follows: sensitivity to neutrons: 0.07 kicks/n/cm{sup 2}.s, sensitivity to {gamma} rays: zero up to 3.10{sup 4} R/H, a background noise at the normal discrimination voltage: 0.01 kicks/s, working H.T.: -500 V, capacity: 40 {mu}{mu}F, average height of pulse: 8 mV, limits of use: from several neutrons to 10{sup 6} n/cm{sup 2}.s. This chamber may be used in all cases where low fluxes of slow neutrons must be measured, especially in the presence of high gamma fluxes, for example in the checking of Pu concentrations in an extraction plant or for the starting up of reactors. (author) [French] La chambre d'ionisation decrite est destinee a la mesure des flux de neutrons lents d'intensite moyenne ou faible, en presence eventuelle de flux gamma tres importants. La capture d'un neutron lent par un materiau fissile, en l'occurrence {sup 235}U, donne naissance a des fragments de fission, particules de grande energie qui ionisent le gaz contenu dans la chambre. Les neutrons sont detectes grace aux impulsions de potentiel, sur l'electrode collectrice de la chambre, provenant de la collection des ions produits par les fragments de fission. Une chaine de mesure comprenant un preamplificateur, un amplificateur 2 Mc, un discriminateur, une echelle

  10. Precisão da retinoscopia sem lentes neutralizadoras na hipermetropia experimental de olho artificial

    Directory of Open Access Journals (Sweden)

    Beatriz Simões-Corrêa

    2012-10-01

    Full Text Available OBJETIVO: Avaliar a acurácia e a precisão da retinoscopia sem lentes neutralizadoras na hipermetropia experimental de olho artificial. MÉTODOS: Observação da projeção da faixa do retinoscópio em olho artificial preparado para apresentar hipermetropias de +1,00 D a +8,00 D. A movimentação da faixa é feita simultaneamente com a variação da sua largura, deslocando a luva do retinoscópio até a obtenção da neutralização do movimento. O retinoscópio foi preparado para dois modos de medida: com escala milimétrica sob a luva e com acoplamento a potenciômetro ligado a multímetro de leitura digital em ohms (Ù. Oito médicos oftalmologistas realizaram 1200 retinoscopias em cada modo de medida, num total de 2400. Calculou-se a média e o desvio padrão das observações. Para comparar os resultados em mm e em ohms (Ù calculou-se o coeficiente de variação (CV a partir dos desvios padrão das observações em cada modo. RESULTADOS: Pelos modos descritos foi possível estimar hipermetropias até +4,00 dioptrias. CONCLUSÃO: A acurácia e a reprodutibilidade experimentais foram boas na identificação de hipermetropias até +4 ,00 D.

  11. Principios para el cálculo de la lente intraocular tras cirugía refractiva corneal

    Directory of Open Access Journals (Sweden)

    Taimí Cárdenas Díaz

    Full Text Available Se estima que aproximadamente un millón o más de pacientes se realizan cirugía refractiva al año. Es por eso que con el envejecimiento son cada día más frecuentes los pacientes con catarata, a quienes previamente se les ha efectuado cirugía refractiva. El cálculo inexacto de la potencia dióptrica de la lente a implantar en la intervención de estos es también un problema de importancia creciente y con él la sorpresa refractiva. Este es mucho más complejo de lo normal, ya que existen dos fuentes de error: la incorrecta predicción de la posición efectiva de la lente por parte de la fórmula y la determinación errónea de la potencia de la córnea por parte de la queratometría. La corrección de estos dos factores permitirá realizar un cálculo correcto en estos ojos. De ahí la motivación para realizar una búsqueda actualizadas de los últimos diez años de diversos artículos publicados, con el objetivo de describir los principios para el cálculo de la lente intraocular tras cirugía refractiva corneal. Se utilizó la plataforma Infomed, específicamente la Biblioteca Virtual de Salud, con todos sus buscadores.

  12. “One Should Have Two Homelands”: Discord and Hope in Soma Morgenstern’s Sparks in the Abyss

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    Kata Gellen

    2017-02-01

    Full Text Available Soma Morgenstern’s three-part novel Sparks in the Abyss, written between 1930 and 1943, exudes a spirit of serenity and optimism at the same time that its narrative is structured by repeated scenes of conflict and violence. This paper seeks to account for the place of discord in the trilogy. Morgenstern uses the interwar Galician homeland as a site to articulate the possibility of traditional Jewish life in modern Europe. By inhabiting two homes—East and West, Galicia and Vienna, secularism and piety—Jews will be able to negotiate the inevitable discord and occasional brutality that they face in the world. The lessons learned by a Western secular Jew in pluralist Galicia create hope for the negotiation of difference, if not for the complete overcoming of violence, on the eve of World War II.

  13. Neurosurgery and prognosis in patients with radiation-induced brain injury after nasopharyngeal carcinoma radiotherapy: a follow-up study

    International Nuclear Information System (INIS)

    Li, Yi; Shi, Xiaolei; Rong, Xiaoming; Peng, Ying; Tang, Yamei

    2013-01-01

    Radiotherapy is the standard radical treatment for nasopharyngeal carcinoma (NPC) and may cause radiation-induced brain injury (RI). Treatment for RI remains a challenge. We conducted this study to investigate the indications of neurosurgery, operation time and prognosis of patients with RI after NPC radiotherapy who underwent neurosurgical management. This was a follow-up study between January 2005 and July 2011. Fifteen NPC cases of RI who underwent neurosurgery were collected. Brain Magnetic resonance imaging (MRI), surgery and histology were studied. The outcome was assessed by LENT/SOMA scales and modified Rankin scale. Brain lesion resection (86.7%) was more common than decompressive craniotomy (13.3%). According to LENT/SOMA scale before and six months after surgery, 13 of 15, 12 of 15, 14 of 15, and 14 of 15 cases showed improvement at subjective, objective, management and analytic domains, respectively. 12 of 15 patients showed improvement of modified Rankin scale after surgery. Three patients who underwent emergency surgery showed significant improvement (average score increment of 2, 2.7, 2.7, 3 and 2 at LENT/SOMA scale subjective, objective, management, analytic, and modified Rankin scale, respectively), as compared with 12 cases underwent elective surgery (average score increment of 1, 1, 1.4, 1.8 and 1 at LENT SOMA scale subjective, objective, management, analytic, and modified Rankin scale, respectively). Neurosurgery, including brain necrotic tissue resection and decompressive craniotomy, improves the prognosis for RI patients, especially for those with indications of emergency surgery

  14. Scale effects and human impact on the elevational species richness gradients

    DEFF Research Database (Denmark)

    Nogues, David Bravo; Araújo, M B; Romdal, T

    2008-01-01

    ), the derived species richness pattern changed progressively from hump-shaped to a monotonic pattern as the scale of extent diminished. Scale effects alone gave rise to as many conflicting patterns of species richness as had previously been reported in the literature, and scale effects lent significantly...

  15. Scales

    Science.gov (United States)

    Scales are a visible peeling or flaking of outer skin layers. These layers are called the stratum ... Scales may be caused by dry skin, certain inflammatory skin conditions, or infections. Examples of disorders that ...

  16. Resultados topográficos en pacientes portadores de lentes de contacto Topographic results achieved patients wearing contact lens

    Directory of Open Access Journals (Sweden)

    Tania Aymeé Díaz Martínez

    2009-06-01

    Full Text Available OBJETIVOS: Analizar los resultados topográficos en pacientes portadores de lentes de contacto y candidatos a cirugía refractiva con excimer láser, en el Hospital "Carlos Juan Finlay"; determinar el comportamiento según edad y sexo; conocer el tipo de lente de contacto empleado y su tiempo de uso; conocer el comportamiento según la edad y el sexo; identificar la relación del patrón topográfico corneal inducido en portadores de lentes de contacto con el moldeamiento corneal y el queratocono. MÉTODOS: Es un estudio retrospectivo de las topografías de los candidatos para cirugía refractiva durante los últimos 2 años, de 80 pacientes (todos ellos portadores de lentes de contacto. Para las exploraciones se emplearon los topógrafos OPTIKON AMF510P y el HUMPHREY. A todos se les realizó un examen oftalmológico completo (refracción manifiesta, biomicroscopia, queratometría, paquimetría y topografía corneal. Se compararon los resultados y su estabilidad. También se analizó la edad, el sexo, el tipo de lentes de contacto, así como su tiempo de utilización. RESULTADOS: Se trataron 158 ojos, de ellos 83 presentaron un patrón topográfico normal, 58 moldeamiento corneal inducido por el uso de lentes de contacto y en 17 se evidenció queratocono. La edad media de los pacientes fue de 27 años. El astigmatismo corneal medio en los pacientes con queratocono fue de -3,25 dioptrías, y de -1,12 dioptrías en pacientes con moldeamiento corneal. La lectura del meridiano más plano en pacientes con queratocono fue de 46,75 dioptrías, y en moldeamiento corneal 43,25 dioptrías. En los queratoconos el meridiano más curvo fue de 54,75 dioptrías, y en el moldeamiento corneal 46,00 dioptrías. CONCLUSIONES: El tipo de lente de contacto, así como su tiempo de uso influyen en la aparición del moldeamiento corneal inducido y el queratocono subclínico, y ambos presentaron un patrón topográfico similar.OBJECTIVES: To analyze the topographic

  17. Lente de contato em crianças: aspectos epidemiológicos Contact lens in children: epidemiological aspects

    Directory of Open Access Journals (Sweden)

    André Luiz Alves Salame

    2008-06-01

    Full Text Available OBJETIVO: Traçar o perfil epidemiológico de crianças encaminhadas para adaptação de lente de contato. MÉTODOS: Foi realizado estudo retrospectivo de pacientes registrados no Setor de lente de contato da Universidade Federal de São Paulo. Os pacientes com até 12 anos de idade foram avaliados quanto ao sexo, idade, diagnóstico, indicação e tipo de lente de contato testada na primeira consulta. RESULTADOS: Dos 73 prontuários avaliados, 34 (46,6% pertenciam a crianças do sexo masculino e 39 (53,4% a crianças do sexo feminino. A idade variou de 2 a 12 com média de 10,2 e desvio-padrão de 2,42 anos. O diagnóstico mais encontrado foi afacia em 16 (21,9% crianças, seguido de ceratocone em 14 (19,1%, leucoma em 11 (15%, anisometropia em 10 (13,7%, ametropia em 9 (12,3%, astigmatismo irregular em 7 (9,5% e ectopia lentis em 4 (5,4%. Uma criança era alta míope (1,3% e outra emétrope (1,3% que possuía desejo de usar lente de contato estética. Em relação às indicações, 52 (71,2% pacientes tinham indicação médica, 9 (12,3% indicação óptica e 12 (16,4% indicação cosmética. Foram testadas lentes em 103 olhos sendo as mais testadas a rígida gás permeável esférica em 43 (41,7%, a gelatinosa esférica em 41 (39,8% e a gelatinosa cosmética em 11 (10,6%. CONCLUSÃO: O perfil epidemiológico dos usuários de lente de contato nessa faixa etária tem como diagnóstico mais prevalente a afacia, a indicação mais freqüente a de ordem médica e a lente mais testada a rígida gás permeável esférica.PURPOSE: To describe the epidemiology of children submitted to contact lens fit. METHODS: Retrospective study of 73 children that had been submitted to contact lens fit at the "Universidade Federal de São Paulo". This study analyzed sex distribution, age, diagnosis, indications and contact lens fitted at first examination. RESULTS: 34 children (46.6% were male and 39 (53.4% female, aged between 2 and 12 years with mean of 10.2 and

  18. Resultados de implante de lente intraocular en niños Results of intraocular lens implantation in children

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    Nashelly I. Mejía Cruz

    2007-12-01

    Full Text Available En este estudio se describen los resultados obtenidos del implante de lente intraocular en niños, quienes acudieron al servicio de Oftalmología Pediátrica de Instituto Cubano de oftalmología “Ramón Pando Ferrer” con el diagnóstico de catarata de diversas etiologías, en período comprendido entre abril del 2002 al 2005 cuyo seguimiento fue durante un año. En nuestro universo de estudio se determinan algunos parámetros como la edad del paciente, etiología de las cataratas, agudeza visual, defecto refractivo preoperatorio y posoperatorio. Se identificó el poder dióptrico del lente intraocular más frecuente, la presencia de complicaciones durante la cirugía y después de esta. Se evaluaron finalmente, los pacientes que requerían de tratamiento adicional como la capsulotomía con láser o membranectomía quirúrgica. El implante del lente intraocular a temprana edad se relacionó con buenos resultados quirúrgicos: mejoría de la agudeza visual corregida, presentándose el astigmatismo como el error refractivo más frecuente. La complicación transoperatorio y postoperatoria más frecuente fue la membrana inflamatoria, mientras que la complicación posoperatoria más frecuente fue la opacidad de la cápsula posterior.This paper described the results of the intraocular lens implantation performed in children, who had been seen at the Pediatric Ophthalmologic Service of " Ramon Pando Ferrer " Cuban Institute of Ophthalmology and had been diagnosed as having cataract of various etiologies, from April 2002 to April 2005. They were all followed-up for a year. Some parameters like the patient’s age, the etiology of cataract, visual acuity, pre-operative and post-operative refractive defect were considered in our study. The dioptric power of the most common intraocular lens and the most frequent complications during and after surgery were identified. The patients requiring additional treatment such as laser capsulotomy and surgical

  19. Sistemas atuais de cuidados e manutenção de lentes de contato Current care and maintenance systems for contact lenses

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    César Lipener

    2008-12-01

    Full Text Available A correta manutenção das lentes de contato é fundamental para se obter sucesso e manter a continuidade de seu uso. É grande o número de pacientes que abandonam o uso de suas lentes por problemas que poderiam ser solucionados com tratamentos relativamente simples ou com uma orientação mais adequada. O mau uso das lentes, associado à má adaptação, contaminação, doenças oculares prévias e fatores ambientais, podem aumentar o número de infecções corneanas através da proliferação de microorganismos. O presente artigo visa apresentar as atualizações em relação aos cuidados e manutenção com as lentes de contato.The proper maintenance of contact lenses is crucial for their success and to maintain the continuity of their use. Many patients abandon the use of their lenses due to problems that could be solved with relatively simple treatments. The misuse of lenses, coupled with poor adjustment, contamination, eye disease and environmental factors may increase the number of corneal infections through the proliferation of microorganisms. This article aims to provide contact lens care and maintenance updates.

  20. Alteraciones oculares y visuales en personas que trabajan con ordenador y son usuarias de lentes de contacto: una revisión bibliográfica

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    Ana Tauste Francés

    2014-01-01

    Full Text Available Fundamentos: El elevado número de personas que trabajando con ordenador utiliza lentes de contacto plantea la cuestión sobre si la suma de estos dos factores de riesgo para la salud visual puede originar un agravamiento del Síndrome Visual Informático. El objetivo de esta revisión es sintetizar el conocimiento científico sobre las alteraciones oculares y visuales relacionadas con la exposición a ordenador en usuarios de lentes de contacto. Métodos: Revisión de artículos científicos (2003-2013 en español e inglés, realizando una búsqueda bibliográfica, en Medline a través de PubMed y en Scopus. Resultados: La búsqueda inicial aportó 114 trabajos, después de aplicar criterios de inclusión/exclusión se incluyeron seis artículos. Todos ellos ponen de manifiesto que las alteraciones al utilizar el ordenador son más frecuentes en las personas usuarias de lentes de contacto, con prevalencias que oscilan de 95,0% al 16,9% que en las que no utilizan lentes de contacto, cuya prevalencia va del 57,5% al 9,9% y con una probabilidad cuatro veces mayor de padecer ojo seco [OR: 4,07 (IC 95%: 3,52-4,71]. Conclusiones: Las personas usuarias de ordenador padecen más alteraciones oculares y visuales cuando además son usuarias de lentes de contacto, pero los estudios son escasos y poco contundentes. Se precisan nuevas investigaciones que analicen la influencia según los tipos de lentes y sus condiciones de uso, tanto en la sintomatología como en la calidad de la lágrima y la superficie ocular. Las lentes de hidrogel de silicona son las que se asocian a mayor confort.

  1. Construcción de un microscopio simple con la lente de un teléfono celular

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    Ernesto Cyrulies

    2014-01-01

    Full Text Available En este artículo se propone la construcción de un microscopio simple recreando el principio de funcionamiento del microscopio de Leeuwenhoek, empleando en este caso una lente de cámara fotográfica de teléfono celular. El dispositivo permite observar y fotografiar estructuras celulares, cuyas imágenes ampliadas posibilitan ver ciertos detalles minúsculos. Se describe una manera sencilla de construirlo con materiales comunes. También se relata la implementación de la propuesta con alumnos de un instituto de formación docente y cuáles fueron sus resultados.

  2. Principales métodos para el cálculo de la lente intraocular después de la cirugía refractiva corneal

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    Taimí Cárdenas Díaz

    Full Text Available Con el surgimiento y el desarrollo de la cirugía refractiva corneal se han podido corregir quirúrgicamente a millones de pacientes con defectos refractivos. Con el cursar de los años comienza a opacarse fisiológicamente el cristalino, y disminuye la agudeza visual en estos pacientes a quienes se les modificó la curvatura corneal. Ante la necesidad de remover el cristalino y de calcular una lente intraocular de potencia adecuada para conseguir la emetropía, surge un nuevo reto a la Oftalmología. El cálculo de la lente intraocular en pacientes con cirugía refractiva corneal es mucho más complejo, pues además de tener longitudes axiales extremas, se añaden factores por la intervención previa que alteran la predictibilidad del resultado visual, con la aplicación de las fórmulas de cálculo de lente intraocular existentes. Se han descrito varios métodos que permiten determinar correctamente la potencia de la lente a implantar, dependiendo de los datos de los que se dispongan; de ahí la motivación para realizar una revisión de diferentes publicaciones con el propósito de describir los principales métodos empleados para realizar el cálculo de la lente intraocular en estos pacientes. Se utilizó la plataforma Infomed, específicamente la Biblioteca Virtual de Salud, con todos sus buscadores.

  3. Experiencia con la lente intraocular RAYNER 620H Experience gained with the use of intraocular lens RAYNER 620 H

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    Juan Raúl Hernández Silva

    2008-06-01

    Full Text Available Un importante eslabón en el progreso alcanzado en la cirugía de cataratas, está fundamentado en el desarrollo industrial paralelo que ha ocurrido durante los últimos años con la introducción de nuevos modelos de lentes intraoculares, como el Rayner 620 H; el perfeccionamiento del instrumental quirúrgico, sistemas de aspiración e irrigación bimanual y bisturí con la medida exacta para colocar el inyector de la lente intraocular. La lente intraocular Rayner 620H significó un gran paso para la facoemulsificación y el control de la opacidad de la cápsula posterior posoperatoria por el diseño peculiar de su óptica y hápticos, que permiten un implante seguro, fácil y una incisión mínima. Se realizó un estudio prospectivo y descriptivo, cuyo universo de estudio fueron 28 ojos con diagnóstico de cataratas a los cuales se les realizó facoemulsificación con implante de lente intraocular Rayner 620 H, en el Centro de Microcirugía Ocular del Instituto Cubano de oftalmología "Ramón Pando Ferrer" en el período comprendido entre junio de 2006 a febrero de 2007. El grupo de edades donde se encontró el de mayor número de pacientes fue en el de más de 60 años. En todos los casos hubo un aumento significativo de la agudeza visual sin corrección y con ella, del preoperatorio al posoperatorio. Hubo un aumento del cilindro queratométrico del preoperatorio al posoperatorio, pero este fue mínimo La pérdida de células endoteliales fue baja del preoperatorio al posoperatorio, respectivamente. No hubo ninguna complicación durante la cirugía ni después de esta. Evaluamos como satisfactoria la efectividad del lente intraocular Rayner 620 H, por el aumento de la agudeza visual del paciente, el bajo astigmatismo inducido, mejoría del campo visual por confrontación, mínima pérdida de células endoteliales, y ausencia de complicaciones y de deslumbramiento posoperatorio en los pacientes.An important link in the advances made by the

  4. Apport de l’IRM dans la prise en charge des compressions médullaires lentes non traumatiques

    Science.gov (United States)

    Badji, Nfally; Deme, Hamidou; Akpo, Geraud; Ndong, Boucar; Toure, Mouhamadou Hamine; Diop, Sokhna Ba; Niang, El Hadji

    2016-01-01

    Les compressions médullaires lentes sont dues au développement dans le canal médullaire d’une lésion expansive. C’est une pathologie très fréquente dont le diagnostic est essentiellement clinique. L’imagerie par résonnance magnétique occupe une place incontournable dans le diagnostic de localisation et la recherche étiologique. En Europe l’étiologie tumorale est prépondérante. Le but de cette étude était de décrire les aspects IRM des compressions médullaires lentes et de déterminer le profil étiologique. Il s’agit d’une étude rétrospective portant sur 97 observations colligées au service de radiologie du CHUN de Fann sur une période de 30 mois (du 08/03/10 au 29/09/12). On été inclus dans l’étude, tous les patients adressés pour un tableau de compression médullaire lente survenu dans un contexte non traumatique. L’âge moyen des patients était de 42,6 ans avec des extrêmes compris entre 04 mois et 85 ans. Nous avons étudié la topographie des lésions (étage rachidien, compartiments canalaires) leur rehaussement et les critères d’orientation étiologique. Le protocole d’examen permettait la réalisation de séquence pondérées T1 sans avec injection de gado, T2, STIR et T2 DRIVE centrées sur les niveaux lésionnels ou les zones suspectes. L’IRM a permis de préciser le siège exact et l’étendue des lésions. L’atteinte du rachis dorsal représentait 42% des cas, suivi du rachis cervical avec 32% des cas. Les atteintes lombo-sacrées et pluri-étagées représentaient respectivement 18% et 08% des cas. Les lésions extradurales représentaient 87% des cas, suivi des lésions intradurales extramédullaires avec 08% des cas et des lésions intramédullaires dans 05% des cas. La particularité du profil étiologique de notre étude est la prédominance des épidurites infectieuses et la fréquence relative des épidurites métastatiques comparée aux séries occidentales. L’IRM vertébro-médullaire occupe

  5. Adaptação de lentes de contato após cirurgia refrativa Contact lens fitting after refractive surgery

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    Adimara da Candelária Renesto

    2005-02-01

    Full Text Available OBJETIVO: Avaliar a adaptação e o uso de lente de contato em pacientes que foram submetidos à cirurgia refrativa. MÉTODOS: Foi realizado estudo retrospectivo de 53 pacientes submetidos à cirurgia refrativa, que posteriormente passaram a usar lente de contato, no período de 1999 a 2003. Foram avaliados a ametropia prévia, tipo de cirurgia realizada, refração pós-cirúrgica, equivalente esférico pós-cirurgia, ceratometria pós-operatória, curva base da lente adaptada, tipo de lente de contato adaptada, acuidade visual com óculos no pós-operatório, acuidade visual final com lente de contato, complicações e motivo da interrupção do uso. O tempo de seguimento variou de 1 mês a 84 meses (média de 42,5 meses. RESULTADOS: Dos 53 pacientes analisados, 19 pacientes foram submetidos a LASIK (Laser Assisted in Situ Keratomileusis, 29 pacientes foram submetidos à RK (ceratotomia radial, 4 pacientes foram submetidos a PRK (ceratectomia fotoablativa e em um paciente não foi possível obter o tipo de cirurgia realizado. Em 61,29% dos pacientes, (57 olhos de um total de 93, foram adaptadas lentes de contato rígidas gás-permeáveis esféricas. Houve melhora da acuidade visual em 60,21% dos casos (AV>20/40, com poucas complicações. CONCLUSÃO: Devido ao número cada vez maior de cirurgias refrativas realizadas, espera-se que aumente o número de pacientes insatisfeitos com o resultado no pós-operatório e para os quais o uso de lentes de contato venha a ser a melhor opção. A adaptação de lentes de contato pós-cirurgia refrativa exige conhecimento e dedicação e em geral tem bons resultados principalmente pela melhora da acuidade visual.PURPOSE: To evaluate the fitting and use of contact lens in patients submitted to refractive surgery. METHODS: This was a retrospective study in 53 patients submitted to refractive surgery who later started to use contact lens, from 1999 to 2003. The parameters were: previous ametropia, refractive

  6. Acuidade visual em implantes bilaterais de lentes intra-oculares monofocais e multifocais Visual acuity of bilateral implants of monofocal and multifocal intraocular lenses

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    Leonardo Akaishi

    2003-01-01

    Full Text Available OBJETIVO: Comparar a acuidade visual de longe e perto de pacientes submetidos à facoemulsificação binocular não simultânea com implante de lentes multifocais ou monofocais. MÉTODOS: Foram selecionados 20 pacientes com lentes multifocais bilaterais e outros 20 pacientes com lentes monofocais também bilaterais, com acuidade visual sem correção melhor ou igual a 0,63 (20/30, medidos separadamente, nos três primeiros meses de pós-operatório. Foi medida a acuidade visual para longe e perto com e sem correção e testes de sensibilidade ao contraste e ofuscamento. RESULTADOS: A acuidade visual sem correção para longe no grupo das monofocais teve média de 0,82 (DP± 0,16 e no grupo das multifocais, 0,94 (DP±0,12, valor de p 0,001. Os dois grupos de lentes tiveram visão com correção para longe igual a 1. No grupo das multifocais, 75% tiveram J1 e 100% tiveram J3 ou melhor sem correção. No grupo das lentes monofocais, 10% tiveram J1 e 70% tiveram J3 ou melhor sem correção. Não houve diferença significante na avaliação com o teste de sensibilidade ao contraste entre os grupos pesquisados. No teste de ofuscamento, os dois grupos tiveram redução da visão, que foi mais acentuada no grupo dos pacientes com lentes multifocais. CONCLUSÃO: A acuidade visual para longe com correção nos pacientes com implante multifocal foi semelhante a dos pacientes com implantes monofocais, embora a acuidade visual para perto no grupo em que foi implantado lente multifocal foi bastante superior ao grupo da lente monofocal. A sensibilidade ao contraste manteve-se semelhante nos dois grupos, já o ofuscamento ("glare test" no grupo multifocal foi maior que no grupo monofocal.PURPOSE: To compare distant and near visual acuity between patients submitted to bilateral nonsimultaneous facoemulsification and implantation of multifocal or monofocal intraocular lenses (IOL. METHODS: Twenty patients with bilateral multifocal IOL and 20 patients with

  7. Revisión bibliográfica sobre los beneficios del coloreado de las lentes destinadas a las actividades deportivas

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    Carlos Montaner Sesmero

    2010-09-01

    Full Text Available El desarrollo de productos comerciales específicos para cada usuario es una línea de actuación preferente para cada vez más empresas del sector deportivo. Algunos de estos productos personalizados, como es el caso de las gafas deportivas con lentes coloreadas, ofrecen prestaciones que aseguran un mejor confort y/o rendimiento deportivo en determinados contextos. Sin embargo, la base científica que apoya el beneficio de dichos artículos es desconocida. Así, el propósito de este estudio es realizar una revisión del trabajo científico publicado que explique el posible beneficio que puede suponer el uso de un tipo de coloreado u otro en las lentes de las gafas deportivas. Para ello, se ha llevado a cabo una revisión bibliográfica centrada en aspectos de confort y de rendimiento visual en la práctica deportiva, a través de bases documentales científicas, de páginas web y de normativa referente al uso de lentes deportivas. La principal conclusión que se puede extraer es que el estado del arte ofrece una limitada base científica para soportar los productos existentes en el mercado, así como para proponer lentes de color para deportes concretos. Queda establecido que a través de determinados filtros coloreados puedan mejorarse los tiempos de reacción y la habilidad visual, pero en caso de abordar esta línea de I+D, sería incluso necesario poner a punto métodos de medida adecuados.

  8. Vitrectomía pars plana y reimplante de lente intraocular en surco Pars plana vitrectomy and intraocular lens repositioning in the sulcus

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    Alejandro Guerra García

    2010-01-01

    Full Text Available Se presentó un caso de lente intraocular luxado a vítreo en paciente con conteo bajo de células endoteliales e intolerancia a lentes de contacto. Se practicó vitrectomía pars plana con reimplante de lente en surco ciliar con el objetivo de demostrar la fiabilidad de la técnica para casos que presenten condiciones adecuadas y situaciones especiales. Se revisó la bibliografía para conocer las tendencias actuales con respecto al manejo de esta patología. El paciente alcanzó una agudeza visual de 20/30. El lente permaneció estable en el surco 3 meses después de practicada la vitrectomía. El manejo de esta entidad debe ser personalizado. La técnica utilizada debe ser siempre la primera opción de tratamiento y parece ser segura en casos cuidadosamente escogidos.A case of dislocated intraocular lens moved to the vitreous cavity in a patient with low endothelial cell count and contact lens intolerance was reported. A pars plana vitrectomy with lens repositioning was performed to demonstrate the safety of this technique for some special cases under adequate conditions. The literature was reviewed to learn about the current management of this pathology. Finally, patient's best visual acuity was 20/30. The stability of the lens was confirmed three month l after the vitrectomy. Management of this disorder should be customized. This technique should be considered as the first option of treatment and seems to be safe in selected cases.

  9. Avaliação do nível de conhecimento quanto ao uso de lentes de contato entre os estudantes de medicina da Faculdade de Medicina do ABC

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    Giovana Arlene Fioravanti Lui

    2010-12-01

    Full Text Available OBJETIVO: Analisar o nível de conhecimento dos usuários de lentes de contato entre os estudantes de medicina da Faculdade de Medicina do ABC (SP quanto aos cuidados, formas de uso, às complicações e à aquisição das lentes. MÉTODOS: Foi aplicado um questionário a todos os alunos usuários de lentes de contato do 1º ao 6º ano de medicina da Faculdade de Medicina do ABC (SP, analisando-se por fim os resultados encontrados. Todos os questionários aplicados foram respondidos. RESULTADOS: 61 estudantes responderam ao questionário. 52,5% afirmaram já terem tido algum tipo de complicação ocular decorrente do uso de lentes de contato. Apesar de a maioria (70,5% estar satisfeito com o uso das lentes de contato, 67% dos que responderam ao questionário estão esperando o grau estabilizar para realizar cirurgia para correção de grau. CONCLUSÃO: Observou-se uma adaptação inadequada, aquisição de lentes de contato em ópticas ou farmácias e complicações oculares graves ocorreram em usuários de lentes de contato considerados diferenciados. Podemos concluir que o médico oftalmologista deverá dar mais atenção ao tema, para que haja menos complicações ao realizar adaptações de lentes de contato.

  10. Biophysics of active vesicle transport, an intermediate step that couples excitation and exocytosis of serotonin in the neuronal soma.

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    Francisco F De-Miguel

    Full Text Available Transmitter exocytosis from the neuronal soma is evoked by brief trains of high frequency electrical activity and continues for several minutes. Here we studied how active vesicle transport towards the plasma membrane contributes to this slow phenomenon in serotonergic leech Retzius neurons, by combining electron microscopy, the kinetics of exocytosis obtained from FM1-43 dye fluorescence as vesicles fuse with the plasma membrane, and a diffusion equation incorporating the forces of local confinement and molecular motors. Electron micrographs of neurons at rest or after stimulation with 1 Hz trains showed cytoplasmic clusters of dense core vesicles at 1.5±0.2 and 3.7±0.3 µm distances from the plasma membrane, to which they were bound through microtubule bundles. By contrast, after 20 Hz stimulation vesicle clusters were apposed to the plasma membrane, suggesting that transport was induced by electrical stimulation. Consistently, 20 Hz stimulation of cultured neurons induced spotted FM1-43 fluorescence increases with one or two slow sigmoidal kinetics, suggesting exocytosis from an equal number of vesicle clusters. These fluorescence increases were prevented by colchicine, which suggested microtubule-dependent vesicle transport. Model fitting to the fluorescence kinetics predicted that 52-951 vesicles/cluster were transported along 0.60-6.18 µm distances at average 11-95 nms(-1 velocities. The ATP cost per vesicle fused (0.4-72.0, calculated from the ratio of the ΔG(process/ΔG(ATP, depended on the ratio of the traveling velocity and the number of vesicles in the cluster. Interestingly, the distance-dependence of the ATP cost per vesicle was bistable, with low energy values at 1.4 and 3.3 µm, similar to the average resting distances of the vesicle clusters, and a high energy barrier at 1.6-2.0 µm. Our study confirms that active vesicle transport is an intermediate step for somatic serotonin exocytosis by Retzius neurons and provides a

  11. Comparação dos métodos soma constante e análise conjunta de fatores para estimar a importância relativa

    OpenAIRE

    Dias, Adriana

    2010-01-01

    A proposta deste trabalho foi comparar os métodos Soma Constante (SC) e Análise Conjunta de Fatores (ANCF) para estimar a importância relativa ((IR%)) dos fatores em estudos da preferência do consumidor. O objetivo principal foi verificar se o método SC pode ser utilizado para avaliar as estimativas de IR (%) obtidas pela ANCF. Foi realizado um estudo para avaliar a intenção de compra de uma bebida láctea sabor café com base na embalagem. Utilizou-se uma amostra de 192 julgadores residentes n...

  12. Lentes de contato filtrantes coloridas nas discromatopsias: relato de casos Absorptive and colored contact lenses in color-vision defects: case report

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    Luciene Chaves Fernandes

    2003-06-01

    Full Text Available As autoras propõem a utilização de lentes de contato filtrantes coloridas para melhora da discriminação de cores e do ofuscamento, em portadores de discromatopsia, na impossibilidade de montagem de filtros coloridos em óculos. Foram adaptadas lentes de contato filtrantes coloridas em dois portadores de discromatopsias, um com deutanopia e outro com acromatopsia. No primeiro, adaptou-se lente rígida filtrante, de polimetilmetacrilato (PMMA, vermelha, no olho não dominante, com o objetivo de melhorar a discriminação de cores. No segundo, colocou-se lente filtrante gelatinosa, de uso diário, de coloração marrom escuro com pupila âmbar, visando melhorar o ofuscamento. No primeiro caso, o paciente manteve inalterada a acuidade visual e também o contraste, porém demonstrou melhora na discriminação das cores ao teste de PV-16. No segundo caso, houve melhora subjetiva acentuada do ofuscamento tanto em ambiente interno, como externo. A acuidade visual e a visão de cores permaneceram sem alterações. Os achados sugerem a possibilidade de contarmos com as lentes de contato filtrantes coloridas como importante auxílio para a melhora na discriminação de cores e ofuscamento, nas discromatopsias.The authors propose the use of absorptive and colored contact lenses as an aid to color defects in making color judgments and reduce glare sensitivity in dichromatic subjects, when the use of filter in glasses is not possible. Absorptive and colored contact lenses were adapted in two dichromatic subjects, one deutanope and the other with achromatopsia. In the former, a hard absorptive, red-colored, polymethacrylate lens was adapted monocularly, in the non-dominant eye to help color judgments. In the latter, a soft absorptive, dark brown-colored lens with amber pupil was worn in both eyes to reduce glare sensitivity. Subject # 1 remained with the same visual acuity and contrast sensitivity and demonstrated a better color perception on the PV-16

  13. Lente fácica de câmara posterior para correção de hipermetropia consecutiva à ceratotomia radial

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    Salera Cristina Moreira

    2003-01-01

    Full Text Available OBJETIVO: Avaliar a eficácia, previsibilidade e segurança do implante de lente fácica de câmara posterior para a correção de hipermetropia consecutiva à ceratotomia radial. MÉTODOS: Foram analisados retrospectivamente os prontuários de seis pacientes (10 olhos com hipermetropia consecutiva à hipercorreção após ceratotomia radial submetidos ao implante de lente fácica de câmara posterior para sua correção. RESULTADOS: O equivalente esférico pré-operatório médio da refração dinâmica foi de +4,65 dioptrias (variando de +2,50 a +6,50 dioptrias e o equivalente esférico pós-operatório médio foi de +0,3375 dioptrias (variando de -0,875 a +2,25 dioptrias. Quando comparamos as acuidades visuais com correção pré e pós-operatórias observamos que três olhos (30% ganharam duas linhas de acuidade visual, dois (20% ganharam uma linha de acuidade visual, um (10% manteve a mesma acuidade visual, três olhos (30% perderam uma linha de acuidade visual e um olho (10% perdeu duas linhas. CONCLUSÃO: O implante da lente fácica de câmara posterior para correção da hipermetropia consecutiva à ceratotomia radial mostrou-se como uma nova opção para o tratamento desta indesejável complicação, entretanto, fazem-se necessários estudos abrangendo maior número de casos e um acompanhamento a longo prazo destes casos.

  14. Mensurações do bulbo ocular e cálculo do poder dióptrico de lentes intraoculares em coelhos

    Directory of Open Access Journals (Sweden)

    M.A.R. Valinhos

    2012-02-01

    Full Text Available Determinaram-se as dimensões oculares de coelhos, empregando ultrassonografia modo-A e ceratometria, a fim de utilizá-las como subsídios para calcular o poder dióptrico de lentes intraoculares a serem implantadas experimentalmente nessa espécie e avaliar se existe diferença entre as mensurações oculares de machos e fêmeas e entre olho esquerdo e olho direito. Foram utilizados 58 animais do grupo genético Botucatu, distribuídos entre 30 fêmeas e 28 machos, com idade média de 85,8±8,29 dias e peso médio de 2,3±0,46kg. O cálculo da lente intraocular foi realizado por meio do software Holladay IOL Consultant®. As fórmulas empregadas para o cálculo foram: Holladay II, Holladay I, Hoffer Q e SRK-T, que calcularam lentes de aproximadamente 48,5 D; 50,27 D; 59,67 D e 49,24 D, respectivamente. A fórmula SRK-T mostrou-se semelhante às fórmulas Holladay II e Holladay I, enquanto entre as demais ocorreram diferenças. As características biométricas oculares avaliadas, assim como o poder dióptrico calculado por uma mesma fórmula, não apresentaram diferenças significativas com relação ao sexo e à lateralidade.

  15. Elaboración y gestión de un programa de mantenimiento para una fábrica de lentes oftálmicos

    OpenAIRE

    Garrafa Ayquipa, Henry Calixto; Garrafa Ayquipa, Henry Calixto

    2007-01-01

    La fabricación de lentes oftálmicos es una industria de poco desarrollo en el Perú. Sin embargo, Topsa se ha preocupado por ser una empresa competitiva, realizando inversiones en tecnología y mejora de sus procesos, convirtiéndola en una empresa lideren la industria. En la última década, las ventas de Topsa crecieron a razón del 20 % anual, por ello se amplió la capacidad de planta adquiriendo nuevas maquinarias. También, se incrementaron los reclamos de los clientes por productos defec...

  16. Lente intra-ocular opaca em diplopia intratável: relato de caso Opaque intraocular lens in intractable diplopia: case report

    Directory of Open Access Journals (Sweden)

    Fernanda Teixeira Krieger

    2006-08-01

    Full Text Available Diplopia intratável tem sido descrita em várias situações. Métodos convencionais como prismas e correção cirúrgica do estrabismo falham em neutralizá-la. O objetivo do trabalho é documentar o caso de uma paciente com estrabismo de longa data, cuja diplopia deteriorou-se ao longo dos anos, e não foi possível resolução com cirurgia, prisma, e oclusão com óculos e lente de contato com pupila opaca. A paciente foi então submetida à facoemulsificação com implante de lente intra-ocular opaca que atingiu o objetivo desejado.Intractable diplopia has been described in many situations but poor results are the rule with standard treatment modalities. The authors report a case of a woman with long-standing strabismus and diplopia who failed to improve following surgery, prism, and occlusive spectacles or contact lenses. Then, she was submitted to phacoemulsification and opaque intraocular lens implantation, which successfully neutralized diplopia.

  17. Acanthamoeba sp.: un caso de queratitis no relacionada con el uso de lentes de contacto Acanthamoeba sp.: a case report in a non-contact lens wearer

    Directory of Open Access Journals (Sweden)

    Claudia Menghi

    2012-12-01

    Full Text Available La queratitis por Acanthamoeba sp. generalmente se relaciona con el uso de lentes de contacto y en menor proporción se vincula con el contacto con agua contaminada. Se caracteriza por una disminución de la capacidad visual y la presencia de un fuerte dolor ocular. al examen clínico, puede confundirse con una infección herpética. Si la infección no es diagnosticada y tratada a tiempo en forma adecuada, puede culminar en la perforación de la córnea y, eventualmente, en la pérdida del ojo. en este trabajo se informa uno de los pocos casos registrados de queratitis por Acanthamoeba sp. no relacionada con el uso de lentes de contacto.Acanthamoeba sp. keratitis is generally related to wearing contact lenses, and, to a lesser extent, to contaminated water. it is characterized by reduced visual capacity and the presence of severe ocular pain. Clinically, it can be mistaken for a herpes infection. if it is not diagnosed, and timely and adequately treated, it can result in corneal perforation and, eventually, in vision loss. One of the few registered cases of Acanthamoeba sp. keratitis not related to the use of contact lenses is herein reported.

  18. Measurements of Neuronal Soma Size and Estimated Peptide Concentrations in Addition to Cell Abundance Offer a Higher Resolution of Seasonal and Reproductive Influences of GnRH-I and GnIH in European Starlings.

    Science.gov (United States)

    Amorin, Nelson; Calisi, Rebecca M

    2015-08-01

    Hypothalamic neuropeptides involved in vertebrate reproduction, gonadotropin releasing hormone (GnRH-I) and gonadotropin-inhibitory hormone (GnIH), can vary in the abundance of immunoreactive cells as a function of the reproductive status and nest box occupation of European starlings (Sturnus vulgaris). While using the abundance of cells as an indicator of the activity of neurohormones is informative, incorporating information on cell size (readily observed using immunohistochemistry) can offer a more detailed understanding of environmentally-mediated changes in hormonal dynamics. In this study, we tested the hypothesis that the size of cells' somas and the estimated concentration of peptides in cells immunoreactive (ir) for GnRH-I and GnIH would vary throughout the breeding season and as a function of nest-box status (resident or not). In the absence of a direct assay of protein, we estimated an index of the concentration of hypothalamic peptides via the relative optical density (i.e., the difference between the mean optical density and the optical density of background staining). In support of our hypothesis, we found that GnRH-I- and GnIH-ir soma size and peptide concentration changed both in males and females throughout the breeding season. Somas were largest and estimated peptide concentration was highest mid-season when compared with earlier in the season or to the non-breeding period. For nest-box residents, GnIH-ir soma size and peptide concentration were higher during the middle of the breeding season than earlier in the breeding season, although residence in the nest box was not related to GnRH-I-ir variables. Our results confirm that previously reported changes in cell abundance mimic changes we see in GnRH-I and GnIH-ir soma size and our proxy for peptide concentration. However, investigating changes in the soma of GnRH-I-ir cells revealed a peak in size during the middle of the breeding season, a change not evident when solely examining data on the

  19. Correção do astigmatismo irregular com lente intraocular tórica em um paciente com catarata e degeneração marginal pelúcida: relato de caso

    Directory of Open Access Journals (Sweden)

    Ana Luiza Biancardi

    2012-12-01

    Full Text Available A degeneração marginal pelúcida (DMP é uma rara ectasia corneana cuja progressão resulta em astigmatismo irregular e baixa visual não corrigidos com óculos ou lentes de contato. O presente relato descreve um paciente com catarata e DMP que foi tratado com facoemulsificação e implante de lente intraocular tórica com recuperação da acuidade visual em ambos os olhos.

  20. Comparison of PMMA, foldable silicone and foldable acrylic hydrophobic intraocular lenses in combined phacoemulsification and trabeculectomy Comparação entre lentes intra-oculares de PMMA, lentes dobráveis de silicone e lentes acrílicas hidrofóbicas dobráveis em cirurgias combinadas de facoemulsificação e trabeculectomia

    Directory of Open Access Journals (Sweden)

    Ernani Serpa Junior

    2005-02-01

    Full Text Available PURPOSE: To compare the postoperative results of phacotrabeculectomy with implantation of PMMA, foldable silicone or foldable hydrofobic acrylic intraocular lens (IOL. SETTING: Glaucoma unit, The Royal Liverpool University Hospital, Liverpool, United Kingdom. METHODS: We studied a total of 124 eyes of three consecutive groups of patients with glaucoma and cataract that underwent phacotrabeculectomy with implantation of a PMMA (30 eyes, a foldable silicone (57 eyes or a foldable acrylic (37 eyes IOL. Postoperative Snellen visual acuity and intraocular pressure (IOP, and early and late complications were assessed. All data were analyzed by means of c² test, Fisher's exact test, ANOVA/MANOVA tests or a combination whenever appropriate. RESULTS: In all three groups the early and late mean postoperative IOPs were significantly lower than the preoperative ones (p25 mmHg and hypotony (IOPOBJETIVO: Comparar os resultados pós-operatórios de facotrabeculectomias com implante de lentes intra-oculares de PMMA, dobráveis de silicone e acrílicas hidrofóbicas dobráveis. MÉTODOS: Estudo comparativo retrospectivo, realizado no Departamento de Glaucoma da "St. Paul's Eye Unit - The Royal Liverpool University Hospital", em Liverpool, Inglaterra, onde foram estudados um total de 124 olhos de três grupos consecutivos de pacientes com glaucoma e catarata que foram submetidos à cirurgia de facotrabeculectomia com implante de lentes intra-oculares (LIO de PMMA (30 olhos, dobráveis de silicone (57 olhos e acrílicas hidrofóbicas dobráveis (37 olhos. Foram registradas a visão e pressão intra-ocular (PIO pré e pós-operatória, assim como as complicações pós-operatórias precoces e tardias. Todos os dados foram analisados utilizando-se o teste c², teste exato de Fisher, teste de ANOVA/MANOVA ou uma combinação deles quando necessário. RESULTADOS: Nos três grupos as PIOs pós-operatórias precoces e tardias foram significativamente inferiores

  1. A Double Slow Neutron Spectrometer; Spectrometre double pour neutrons lents; Dvojnoj spektrometr medlennykh nejtronov; Espectrometro doble para neutrones lentos

    Energy Technology Data Exchange (ETDEWEB)

    Bondarenko, I I; Liforov, V G; Nikolaev, M N; Orlov, V V; Parfenov, V A; Semenov, V A; Smirnov, V I; Turchin, V F [Fehi, Moscow, SSSR (Russian Federation)

    1963-01-15

    The neutron spectrometer described in the paper is intended for measurements of the angular and energy distribution of monochromatic slow neutrons, inelasticaily scattered by liquid and solid bodies. Experiments of this type permit detailed information to be obtained concerning the dynamics of the atoms in various aggregate states of a substance. The spectromeeter is based on the time-of-flight method. The pulse source of neutrons is the IBR (1) reactor. A mechanical interrupter, rotating synchronously with the disc of the IBR and having a prescribed phase shift, serves as the monochromator. A special phasing system ensures a phasee stability better than 0.5{sup o}. The neutrons scattered by the sample are recorded by a scintillation detector set at a given angle to the neutron beam. The resolving power of the spectrometer is - 15 {mu}s/m. The paper gives a detailed description of the construction of the spectroscope and its characteristics. (author) [French] Le spectrometre neutronique decrit dans le memoire est destine a mesurer la distribution en energie, la distribution angulaire et la diffusion inelastique des neutrons lents monochromatiques dans des liquides et des solides. Les experiences de ce genre permettent d'obtenir des renseignements detailles sur la dynamique des atomes dans de divers etats de la matiere. Le spectrometre est fonde sur la mesure du temps de vol. Comme source puisee de neutrons on a utilise le reacteur IBR-1. Le systeme monochromateur etait constitue par un interrupteur mecanique en rotation synchronisee avec celle du disque du reacteur IBR, avec un dephasage determine. Un dispositif special de dephasage assure la stabilite de la phase a 0,5{sup o} pres. La diffusion des neutrons par l'echantillon est enregistree a l'aide d'un detecteur a scintillations dispose sous un angle determine par rapport au faisceau de neutrons. Le pouvoir de resolution du spectrometre est d'environ 15 {mu}s/m. Les auteurs decrivent en detail la construction du

  2. Phase II study of vitamin E and pentoxifylline in patients with late side effects of pelvic radiotherapy

    International Nuclear Information System (INIS)

    Gothard, Lone; Cornes, Paul; Brooker, Sonja; Earl, Judith; Glees, John; Hall, Emma; Peckitt, Clare; Tait, Diana; Yarnold, John

    2005-01-01

    Background and purpose: Radiation-induced tissue fibrosis is a common adverse effect of curative treatment for pelvic cancer. Pilot studies testing alpha-tocopherol and pentoxifylline provide evidence of clinical regression of superficial radiation fibrosis after radiotherapy. Patients and methods: Twenty-seven eligible research volunteers with a minimum of one grade 3 or 4 disability (LENT SOMA) due to previous radiotherapy were entered into the study. Volunteers were given dl-alpha tocopheryl acetate 500 mg twice a day orally plus pentoxifylline 400 mg twice a day orally over a period of 6 months. Clinical assessment of late side effects recorded using LENT SOMA scales was selected as the primary endpoint, taken at baseline and at 6 and 12 months post-registration. Patient self-assessment of function and quality of life was assessed as a secondary endpoint using the EORTC QLQ-C30 core questionnaire and the EORTC QLQ-CR38 pelvic module. Magnetic resonance imaging was undertaken in 13/23 evaluable volunteers before and after 6 months of therapy. Results: At 12 months post-registration there were 4 out of 23 responders. At 6 months post-registration there was a statistically significant improvement (i.e. reduction) in the median of the LENT SOMA summed scores in all areas assessed apart from 'male sexual dysfunction', 'vulva' and 'vagina' which were unchanged at 6 months. The median total LENT SOMA score at baseline and 6 months was 49 and 34, respectively, with a median change in total LENT SOMA score between baseline and 6 months of 9 (IQR 7-18) (P<0.001). The maximum LENT SOMA scores improved over the study period, with a total number of 82 maximum grade 3 or 4 normal tissue scores at baseline (median of four complications per person) reduced to a total number of 67 maximum grade 3 or 4 scores at 6 months post-registration (median of 3 complications per person), i.e. a median reduction in severe complications of one per person. LENT SOMA scores at 12 months were

  3. Perfil demográfico e comportamental de pacientes com indicação médica óptica de lentes de contato

    Directory of Open Access Journals (Sweden)

    Fernanda Lika Tabushi

    Full Text Available RESUMO Objetivos: Avaliar o perfil demográfico e comportamental de pacientes com indicação médica óptica de lentes de contato (LC em um hospital público de Curitiba. Métodos: Estudo transversal realizado através de questionário em pacientes atendidos no serviço de lentes de contato do ambulatório do SUS do Hospital de Olhos do Paraná, no período de 02 de setembro de 2014 a 04 de agosto de 2015. Resultados: Dos 69 entrevistados, 56,52% fizeram LC. Destes, 55,07% têm entre 20-49 anos, 69,56% são mulheres, 40,58% com ensino médio completo e 36,23% com 2 a 6 salários mínimos. Predominaram a lente rígida com 66,67%, com menos de 8 horas de uso em 41,02% e desconforto durante o uso em 59%. A limpeza das LC é feita ao colocar e ao retirar em 87,18% dos casos, com 71,8% utilizando solução própria para LC. Alto custo da compra foi o principal motivo do não uso de LC, com 70% dos pacientes que não fizeram uso desse recurso. Conclusões: Dos entrevistados, 56,52% iniciaram o uso de LC, sendo o ceratocone a doença mais indicada. Foi demonstrado nesse estudo que os pacientes em questão têm boa orientação quanto a manuseio e manutenção das LC. Apesar dos inquestionáveis avanços da tecnologia médica, continuam ocorrendo a desistência do uso desse recurso principalmente pelo custo e medo do manuseio. É responsabilidade do especialista esclarecer os benefícios que os pacientes com indicação médica terão com o uso de LC, assim como motivar o seu uso.

  4. Efeito do uso de lente escleral cosmética na sensibilidade tátil corneal em phthisis bulbi Effect of ocular prosthesis on cornea sensitivity in phthisis bulbi

    Directory of Open Access Journals (Sweden)

    Lucia Miriam Dumont Lucci

    2004-10-01

    Full Text Available OBJETIVOS: Comparar a sensibilidade tátil corneal entre olhos normais e aqueles com phthisis bulbi e avaliar as alterações provocadas na sensibilidade tátil corneal pelo uso de lente escleral cosmética em phthisis bulbi. MÉTODOS: Estudo prospectivo de 23 pacientes com phthisis bulbi unilateral. Foram realizadas medidas da sensibilidade tátil corneal em ambos os olhos utilizando-se o estesiômetro de Cochet-Bonnet antes e após 3 meses do uso da lente escleral cosmética. RESULTADOS: Em todos os pacientes, a medida da sensibilidade tátil corneal no olho com phthisis bulbi foi menor do que no contralateral (controle. Em 96% houve diminuição da sensibilidade tátil corneal após a adaptação da lente escleral cosmética. CONCLUSÃO: Após a adaptação da lente escleral cosmética, ocorre diminuição da sensibilidade tátil corneal nos olhos. A fisiopatologia é semelhante à encontrada nos usuários de lentes de contato.PURPOSE: To compare corneal sensitivity between normal eyes and those whith phthisis bulbi and also to analyze the alterations of corneal sensitivity in phthisis bulbi induced by wearing ocular prosthesis. METHODS: Prospective study of 23 patients with unilateral phthisis bulbi. Bilateral cornea sensitivity was evaluated using the Cochet-Bonnet esthesiometer before and after 3 months of wearing ocular prosthesis. RESULTS: In all patients, corneal sensitivity of the eye with phthisis bulbi was lower than that of the normal eye (control. In 96% there was decrease of corneal sensitivity after adaptation of ocular prosthesis. CONCLUSION: After wearing ocular prosthesis, there is a reduction in corneal sensitivity in phthisis bulbi. The pathophysiology seems to be the same as that found in contact lens wearers.

  5. Crianças usuárias de lente de contato nos serviços público e privado: análise comparativa Pediatric contact lens users in public and private services: comparative analysis

    Directory of Open Access Journals (Sweden)

    Daniela Araújo Toscano

    2009-04-01

    Full Text Available OBJETIVOS: Analisar as indicações, tipo, complicações do uso de lentes de contato e acuidade visual em crianças de serviços de Oftalmologia público e privado. MÉTODOS: Os dados dos prontuários de 59 crianças usuárias de lentes de contato em serviço privado (Hospital de Olhos de Pernambuco - Grupo 1, e 43 no serviço público (Fundação Altino Ventura - Grupo 2, foram analisados. A coleta de dados incluiu características sociodemográficas, idade da primeira consulta, indicação do uso da lente, tipo de lente, complicações e acuidade visual. RESULTADOS: As mais comuns indicações do uso de lente de contato no grupo 1 foram: ametropia (55,9%, anisometropia (18,6% e esotropia (16,9%. Neste grupo o leucoma e phthisis não estavam presentes. No grupo 2, as indicações mais comuns foram: anisometropia (23,2%, ametropia e leucoma (18,6% cada, e phthisis (16,3%. A esotropia não apareceu no grupo 2. O tipo de lente de contato mais prescrita foi a gelatinosa de uso permanente (não descartável no grupo 1 (45,8% e no grupo 2 (32,6%. A complicação mais encontrada no grupo 1 foi desconforto (33,3% e no grupo 2 perda da lente (60%. CONCLUSÕES: A indicação de ametropia predominou nos pacientes privados e as anisometropias nos públicos. O tipo de lente de contato mais prescrita nos dois grupos foi a gelatinosa de uso permanente. A complicação mais frequente no grupo 1 foi desconforto e no grupo 2 perda da lente. A acuidade visual na maioria dos pacientes manteve-se.PURPOSE: To analyze the indications, type and complications of contact lens use and visual acuity in children, in ophthalmological, public and private, services. METHODS: The information from the medical records of 59 contact lens users at a private service (Hospital de Olhos de Pernambuco - Recife - PE- Brazil - group 1, and 43 at public service (Fundação Altino Ventura - Recife - PE - Brazil - group 2, was analyzed. The collected data included: demographic information

  6. Espectrofotometria de lentes oftálmicas filtrantes coloridas sob radiação ultravioleta a e luz visível Spectrophotometry of ophthalmic filtering color lenses under ultraviolet radiation and visible light

    Directory of Open Access Journals (Sweden)

    Luís Felipe Fornaciari Ramos

    2003-06-01

    Full Text Available OBJETIVO: Determinar a transmitância das lentes oftálmicas filtrantes coloridas submetidas à radiação UV A e luz visível e comparar seus resultados na faixa de comprimento de onda compreendida entre 320 e 800 nanômetros (nm. MÉTODOS: Análise espectrofotométrica das lentes filtrantes amarela 1, laranja, verde e fumê da marca "Danny" e amarela 2 da marca "Rio de Janeiro", disponíveis em nosso meio, utilizando-se espectrofotômetro Modelo 6.400, marca JEM Way. RESULTADOS: Todas as lentes estudadas apresentaram padrões de transmitância bastante individualizados, com curvas variáveis para os diversos comprimentos de onda. Na faixa es- pectrofotométrica de 320 a 400 nm, todas as lentes apresentaram transmitância inferior a 4% sendo que a lente amarela 1 apresentou a maior média (3,7 % ao passo que a fumê apresentou a menor média 0,45%. Contudo não foi observado uma diferença estatisticamente significativa entre estas lentes; a lente amarela 2 mostrou melhor proteção em comparação à lente amarela 1 e a laranja. Na análise espectrofotométrica realizada em diferentes posições da mesma lente constatou-se diversidade na curva de variância, apesar de não demonstrar diferença estatisticamente significativa. CONCLUSÕES: Para se indicar um filtro com segurança, as propriedades espectrais do filtro devem ser determinadas pela análise espectrofotométrica. É mais importante a capacidade de filtrar radiações luminosas do que somente ser colorido ou não.PURPOSE: Determination of transmittance curves through spetrophotometric measurementes of color filtering lenses submitted to UVA and light visible radiation, and comparison of the results in the band between 320 and 800 nanometres (nm. METHODS: The filtering color of Danny yellow 1, orange, green and grey and Rio de Janeiro yellow 2 lenses have been analyzed using JEM Way model 6.400 spectrophotometer. RESULTS: All lenses showed distinct and variable transmittance in the

  7. Homogeneous distribution of large-conductance calcium-dependent potassium channels on soma and apical dendrite of rat neocortical layer 5 pyramidal neurons.

    Science.gov (United States)

    Benhassine, Narimane; Berger, Thomas

    2005-02-01

    Voltage-gated conductances on dendrites of layer 5 pyramidal neurons participate in synaptic integration and output generation. We investigated the properties and the distribution of large-conductance calcium-activated potassium channels (BK channels) in this cell type using excised patches in acute slice preparations of rat somatosensory cortex. BK channels were characterized by their large conductance and sensitivity to the specific blockers paxilline and iberiotoxin. BK channels showed a pronounced calcium-dependence with a maximal opening probability of 0.69 at 10 microm and 0.42 at 3 microm free calcium. Their opening probability and transition time constants between open and closed states are voltage-dependent. At depolarized potentials, BK channel gating is described by two open and one closed states. Depolarization increases the opening probability due to a prolongation of the open time constant and a shortening of the closed time constant. Calcium-dependence and biophysical properties of somatic and dendritic BK channels were identical. The presence of BK channels on the apical dendrite of layer 5 pyramidal neurons was shown by immunofluorescence. Patch-clamp recordings revealed a homogeneous density of BK channels on the soma and along the apical dendrite up to 850 microm with a mean density of 1.9 channels per microm(2). BK channels are expressed either isolated or in clusters containing up to four channels. This study shows the presence of BK channels on dendrites. Their activation might modulate the shape of sodium and calcium action potentials, their propagation along the dendrite, and thereby the electrotonic distance between the somatic and dendritic action potential initiation zones.

  8. Facoemulsificación e implante de lente intraocular en cataratas causadas por uveitis Phacoemulsification and intraocular lens implantation in patients with cataract caused by uveitis

    Directory of Open Access Journals (Sweden)

    Dayamí Pérez Gómez

    2008-06-01

    Full Text Available OBJETIVO: Evaluar los resultados de la facoemulsificación y el implante de lente intraocular en cataratas causadas por uveítis. MÉTODOS: Se estudiaron 37 ojos con 6 meses de inactividad inflamatoria, agudeza visual menor de 0,6 y edad media de 47 años. Se excluyeron otras enfermedades que disminuyeran la visión. En el preoperatorio se prescribió antiinflamatorios. Se realizó la facoemulsificación con implante de lente intarocular (PMMA, óptica 6 mm; durante el seguimiento desde 24 h/6 meses se indicó antiinflamatorios esteroideos, no esteroideos e inmunosupresores hasta 6 semanas. RESULTADOS: Se observaron numerosas alteraciones del segmento anterior secundarias a las uveítis padecidas (posquirúrgicas, inespecíficas, ciclítis heterocrómica de Fuchs, postraumáticas, síndrome de Reiter, por toxoplasmosis y otras coroiditis infecciosas y por artritis reumatoide juvenil. No hubo recurrencia posquirúrgica de la uveítis en 9 ojos (24,3 %. Las complicaciones estuvieron relacionadas con la uveítis, la cirugía, la actividad inflamatoria, y la reacción del epitelio capsular. La opacidad capsular posterior apareció en 11 pacientes (29,7 % asociada a edad joven. La evolución individual se consideró satisfactoria en 30 (81,1 % pacientes con mejoría de la visión hasta 0,8-1,0 en 28 (75,6 % y 0,5-0,6 en 2 (5,4 %. CONCLUSIONES: La facoemulsificación con implante de lente intarocular es de gran utilidad en las cataratas posuveítis al condicionar poca agresión quirúrgica, ser controlable la inflamación y proporcionar buenos resultados visuales además del reordenamiento anatomofisiológico del segmento anterior.OBJECTIVE: To assess the results of phacoemulsification and intraocular lens implantation in cataracts caused by uveitis. METHODS: Thirty seven eyes with no inflammation for 6 months, visual acuity below 0.6 and average age of 47 years were studied. Other diseases affecting the vision were excluded. The preoperative

  9. Experiments on the thermalization of slow neutrons by liquid hydrogen (1962); Experience de thermalisation de neutrons lents par de l'hydrogene liquide (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Cribier, D; Jacrot, B; Lacaze, A; Roubeau, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Institut Fourier, 38 - Grenoble (France)

    1962-07-01

    In order to increase the flux of neutrons of long wave-length ({lambda} > 4 A) emerging from a channel in the EL-3, a liquid hydrogen device was introduced into a channel of the reactor (Channel H{sub 1}). The principle of the device is simple. A volume of liquid hydrogen is introduced as close as possible to the reactor core into a region of intense isotropic flux. This hydrogen slows down the slow neutrons; because of the very small mean free diffusion path of slow in hydrogen, this slowing down is considerable even in a small volume of liquid hydrogen, and the spectrum temperature of neutrons emerging from the volume of liquid hydrogen can therefore be shifted. The intensity gain for neutrons with a wave length {lambda}, is a G ({lambda}) function which, for perfect thermalization and ignoring capture, is expressed by: G ({lambda}) = 225 exp (- 45.3/{lambda}{sup 2}), assuming a temperature of 300 deg. K for the neutrons before cooling and is 20 deg. K after cooling. For a wave-length of 5 A, the theoretical maximum gain of thus about 37. (authors) [French] Dans le but d'accroitre le flux des neutrons de grande longueur d'onde ({lambda} > 4 A) sortant d'un canal de la pile EL-3, un dispositif a hydrogene liquide a ete introduit dans un canal de la pile (canal H{sub 1}). Le principe du dispositif est simple. Un volume d'hydrogene liquide est introduit le plus pres possible du coeur de ia pile dans une region de flux intense et isotrope. Les neutrons lents sont ralentis par cet hydrogene; a cause du tres faible libre parcours moyen de diffusion des neutrons lents dans l'hydrogene, ce ralentissement est important meme dans un faible volume d'hydrogene liquide et l'on peut ainsi deplacer la temperature du spectre des neutrons sortant du volume d'hydrogene liquide. Le gain en intensite des neutrons de longueur d'onde {lambda} est une fonction G ({lambda}) qui pour une thermalisation parfaite et en negligeant la capture, s'exprime par: G ({lambda}) = 225 exp (- 45

  10. Confirmação do cálculo de lente intraocular através da refração intraoperatória

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    Ana Luiza Biancardi

    2011-04-01

    Full Text Available Este relato descreve a utilização do método refracional intraoperatório para confirmação do cálculo da lente intraocular (LIO. Paciente de 67 anos com acuidade visual (AV igual a 20/60 no olho esquerdo (OE com correção igual a -21,50 esf -400 cil a 170 devido à LIO de silicone 3 peças impregnada por óleo de silicone. Foi indicada a troca da LIO, porém as medidas biométricas pré-operatórias eram variáveis e não confiáveis. Foi realizado o cálculo intraoperatório e o paciente foi submetido à troca da LIO impregnada por uma LIO acrílica 3 peças. O paciente atingiu AV no OE igual a 20/30 com correção igual a -125 esf -1,25 cil a 180. A análise da LIO explantada confirmou a impregnação por óleo de silicone. O cálculo refracional intraoperatório é muito importante para confirmação do valor da LIO.

  11. Desempenho visual de lentes de contato gelatinosas de diferentes tipos baseado na análise de frentes de onda Optical performance of different soft contact lenses based on wavefront analysis

    Directory of Open Access Journals (Sweden)

    Roberta Fagnani Gatti

    2008-12-01

    Full Text Available OBJETIVOS: Avaliar e comparar o desempenho visual, por meio da análise de frentes de onda, de seis diferentes tipos de lentes de contato gelatinosas [Cooperflex® (Coopervision, Frequency® 55 Aspheric (Coopervision, World Vision FW® (World Vision, Pure Vision® (Bausch & Lomb, Focus® Monthly (Ciba Vision, Focus® Choice AB (Ciba Vision]. MÉTODOS: Realizou-se estudo prospectivo em amostra constituída por 130 olhos de 71 indivíduos portadores de miopia ou hipermetropia até 6,00D e astigmatismo até 1,50D, com acuidade visual corrigida com óculos igual ou superior a 20/20. Os sujeitos foram inicialmente submetidos ao exame clínico oftalmológico e posteriormente, ao exame de análise de frentes de onda com o aberrômetro LADARWave® (Alcon, em duas condições: sem correção óptica e em uso de um dos tipos de lente de contato incluídos no estudo, com grau correspondente ao equivalente esférico do paciente e corrigido pela distância vértice. Para análise de resultados os indivíduos foram divididos em seis grupos similares, sendo testado em cada grupo um dos tipos de lente incluídos no estudo. RESULTADOS: Mudanças nos valores das aberrações de alta ordem foram verificadas durante uso das lentes de contato. De 130 olhos estudados, 78 apresentaram aumento no valor de RMS total durante o uso da lente. Os seis tipos de lente estudados demonstraram tendência ao aumento no valor médio de RMS total durante seu uso, sem diferença estatisticamente significante entre as mesmas. O estudo demonstrou tendência ao aumento no valor médio das aberrações tipo "coma" durante o uso das lentes. As lentes Frequency® Aspheric e Cooperflex® apresentaram melhor desempenho visual em relação ao "coma". O estudo demonstrou tendência à diminuição no valor médio das aberrações esféricas durante o uso das lentes, sendo esta tendência maior nos pacientes míopes em relação aos hipermétropes. Foi demonstrado tendência ao aumento no

  12. Complicación poco frecuente del uso de lentes de contacto duros: Presentación de 1 caso Rare complications of the use of hard contact lens: A case report

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    Elizabeth Escalona Leyva

    2003-12-01

    Full Text Available Se presentó una rara complicación con el uso de lentes de contacto duros en una paciente femenina de 45 años de edad, con antecedentes de 15 años de uso que acudió a la consulta por pérdida de sus lentes de contacto de 15 días de evolución. Se detectó aumento de volumen, doloroso en el párpado superior izquierdo donde se encontró en su eversión el lente "sembrado" en el tarso con granuloma que lo envuelve. Se presentan los hallazgos clínicos y la evolución.A rare complication of the use of hard contact lenses. A case report A rare complication with the use of hard contact lenses was observed in a 45-year-old female patient who had worn them during 15 years and visited the physician's office 15 days after losing her contact lenses. It was observed increase of volume, painful in the left upper eyelid, where it was found in its eversion the lens "planted" in the tarsus with a granuloma covering it. The clinical findings and evolution are presented.

  13. JNK1 Controls Dendritic Field Size in L2/3 and L5 of the Motor Cortex, Constrains Soma Size and Influences Fine Motor Coordination

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    Emilia eKomulainen

    2014-09-01

    Full Text Available Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that JNK1 regulates the dendritic field of L2/3 and L5 pyramidal neurons of the mouse motor cortex (M1, the main excitatory pathway controlling voluntary movement. In Jnk1-/- mice, basal dendrite branching of L5 pyramidal neurons is increased in M1, as is cell soma size, whereas in L2/3, dendritic arborization is decreased. We show that JNK1 phosphorylates rat HMW-MAP2 on T1619, T1622 and T1625 (Uniprot P15146 corresponding to mouse T1617, T1620, T1623, to create a binding motif, that is critical for MAP2 interaction with and stabilization of microtubules, and dendrite growth control. Targeted expression in M1 of GFP-HMW-MAP2 that is pseudo-phosphorylated on T1619, T1622 and T1625 increases dendrite complexity in L2/3 indicating that JNK1 phosphorylation of HMW-MAP2 regulates the dendritic field. Consistent with the morphological changes observed in L2/3 and L5, Jnk1-/- mice exhibit deficits in limb placement and motor coordination, while stride length is reduced in older animals. In summary, JNK1 phosphorylates HMW-MAP2 to increase its stabilization of microtubules while at the same time controlling dendritic fields in the main excitatory pathway of M1. Moreover, JNK1 contributes to normal functioning of fine motor coordination. We report for the first time, a quantitative sholl analysis of dendrite architecture, and of motor behavior in Jnk1-/- mice. Our results illustrate the molecular and behavioral consequences of interrupted JNK1 signaling and provide new ground for mechanistic understanding of those prevalent neuropyschiatric disorders where genetic disruption of the JNK pathway is central.

  14. Perfil dos alunos usuários de lentes de contato do curso de Medicina da Universidade Estadual Paulista - UNESP - Botucatu Profile of medical students from the Universidade Estadual Paulista - UNESP - Botucatu, who wear contact lenses

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    Vanessa Gonçalves Vidotti

    2006-04-01

    Full Text Available OBJETIVO: Analisar o perfil dos usuários de lentes de contato entre os estudantes de medicina da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista - UNESP - Botucatu (SP, quanto à ametropia, à aquisição, aos cuidados e às complicações. MÉTODOS: Foi aplicado um questionário aos alunos do 1º ao 6º ano de Medicina da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista - UNESP - Botucatu (SP, perfazendo um estudo analítico transversal. RESULTADOS: Foram 566 entrevistados. Destes, 155 (27,4% usavam lente de contato. Das lentes de contato usadas, 94,8% eram gelatinosas, e em 98,7% o grau era negativo. O descarte dessas lentes era mensal em 46,9% dos entrevistados e 63,9% a utilizavam, em média, 14 horas/dia. Faziam aquisição da lente de contato em óptica ou farmácia 14,1% dos estudantes. Faziam a higiene ao colocá-las e ao retirá-las dos olhos, 46,5%. As complicações referentes aos olhos vermelhos eram 51,0%; 44,5%, embaçamento; e 42,6%, sensação de corpo estranho, além de 4 estudantes relatarem "ceratite". CONCLUSÕES: A maioria dos alunos utilizava lentes hidrofílicas, descarte mensal e grau negativo. A adaptação inadequada, aquisição de lentes de contato em ópticas ou farmácias e complicações graves ocorreram, mesmo nos usuários socioculturalmente considerados diferenciados. Em vista disso, demanda a extrema necessidade de maior atenção na abordagem do tema em questão, a fim de prevenir o comprometimento visual permanente.PURPOSE: To analyze the ametropy, way of acquisition, the care and complications related to contact lens wear among medical students from Faculdade de Medicina de Botucatu da Universidade Estadual Paulista - UNESP - Botucatu (SP. METHODS: Questionnaire applied to students from the 1st to the 6th year of the Medical school of the Faculdade de Medicina de Botucatu da Universidade Estadual Paulista - UNESP - Botucatu (SP, forming an analytical cross

  15. Desempenho visual na correção de miopia com óculos e lentes de contato gelatinosas Visual performance in myopic correction with spectacles and soft contact lenses

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    Breno Barth

    2008-02-01

    Full Text Available OBJETIVOS: Avaliar o desempenho visual, por meio da acuidade visual LogMAR de alto contraste, sensibilidade ao contraste e análise de frentes de onda de indivíduos portadores de miopia com ou sem astigmatismo, corrigidos com óculos e com três diferentes lentes de contato gelatinosas [Acuvue® 2 (Vistacon J&J Vision Care Inc., EUA, Biomedics® 55 (Ocular Science, EUA e Focus® 1-2 week (Ciba Vision Corporation, EUA]. MÉTODOS: Estudo clínico e prospectivo com intervenção em amostra constituída por quarenta indivíduos portadores de miopia entre -1,00 D e -4,50 D, sem ou com astigmatismo até -0,75 D. RESULTADOS: A sobrerefração objetiva realizada pelo aberrômetro Zywave detectou diferença significativa entre as lentes de contato gelatinosas Acuvue® 2 e Biomedics® 55, em relação aos componentes refrativos esfera e equivalente esférico, que se mostraram hipercorrigidos em relação às lentes de contato gelatinosas Focus® 1-2 week. A acuidade visual LogMAR e sensibilidade ao contraste não detectaram diferenças no desempenho visual com os óculos e com as três lentes de contato gelatinosas. A análise de frentes de onda detectou diferença significativa na aberração de terceira ordem sem e com as lentes de contato gelatinosas, com melhor desempenho visual com as lentes de contato gelatinosas Acuvue® 2 e Biomedics® 55. CONCLUSÕES: A análise de frentes de onda detectou diferenças no desempenho visual com óculos e com as lentes de contato gelatinosas, sendo, portanto, uma medida mais sensível da função visual que a acuidade visual LogMAR de alto contraste e a sensibilidade ao contraste. O modelo de avaliação de desempenho visual com análise de frentes de onda utilizado nesta investigação serve de modelo para pesquisas semelhantes.PURPOSE: To evaluate the visual performance by high contrast visual acuity, contrast sensitivity and wavefront in myopic patients with or without astigmatism corrected with spectacles and

  16. Aderência bacteriana in vitro a lentes intra-oculares de polimetilmetacrilato e de silicone In vitro bacterial adherence to silicone and polymetylmethacrylate intraocular lenses

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    Claudete Inês Locatelli

    2004-04-01

    Full Text Available OBJETIVOS: Verificar a aderência bacteriana a lentes intra-oculares de silicone e de polimetilmetacrilato como possível fator de risco no desenvolvimento de endoftalmite pós-operatória, utilizando-se um modelo in vitro com três microrganismos potencialmente patogênicos. MÉTODOS: As análises foram realizadas com cepas de Staphylococcus aureus ATCC 29213, Staphylococcus epidermidis (amostra clínica e Pseudomonas aeruginosa ATCC 27853 incluindo a determinação de curvas de crescimento, testes para verificação de produção de cápsula, avaliação da hidrofobicidade, testes de aderência a diferentes materiais, microscopia óptica, microscopia eletrônica de varredura e microscopia de força atômica. RESULTADOS: A produção de cápsula e a aderência das três diferentes cepas não mostraram qualquer relação com a quantidade de microrganismos; em relação às lentes intra-oculares de polimetilmetacrilato e de silicone, não houve diferença estatisticamente significativa na aderência de S. aureus e S. epidermidis; P. aeruginosa foi o microrganismo mais aderente a ambos os materiais. A microscopia eletrônica de varredura confirmou estes achados em relação à aderência, ao peso que a microscopia de força atômica evidenciou a produção de biofilme pelas cepas de S. aureus, S. epidermidis e P. aeruginosa. CONCLUSÕES: Constatou-se, in vitro, que os materiais analisados não diferiram com relação à taxa de aderência bacteriana, porém, P. aeruginosa apresentou maior eficiência de adesão entre as bactérias testadas. Todas as cepas produziram biofilme. Silicone foi o material mais hidrofóbico, quando comparado ao polimetilmetacrilato.PURPOSE: To evaluate bacterial adherence to silicone and polymetylmethacrylate (PMMA intraocular lenses as a risk factor for postsurgery endophthalmitis by using an in vitro model with three potentially pathogenic microorganisms. METHODS: In vitro experiments were carried out with the

  17. Lente fácica de câmara posterior para correção da miopia Posterior chamber phakic lens for the correction of myopia

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    Ricardo Queiroz Guimarães

    2001-02-01

    Full Text Available Objetivo: Avaliar a eficácia, previsibilidade e segurança do implante de lente intra-ocular de câmara posterior em pacientes com miopia moderada e elevada. Métodos: Analisamos os resultados das cirurgias realizadas em 93 olhos de 54 pacientes para implante de lente fácica de câmara posterior com a finalidade de corrigir miopia moderada e elevada. O objetivo da cirurgia era a emetropia. O acompanhamento médio foi de 9 meses, variando de 1 a 38 meses (desvio padrão 10,45. Resultados: O equivalente esférico médio pré-operatório era -13,56 D (variando de -5,75 a -20,38 D e o equivalente esférico médio pós-operatório no último exame foi -0,92 D (variando de -3,88 a +1,00 D. No último exame, 39 olhos (41,9% se encontravam entre ±0,50 D da emetropia, 64 olhos (68,8% estavam entre ±1,00 D e 88 olhos (94,6% estavam entre ±2,00 D da emetropia. Um ganho de duas ou mais linhas de visão foi observado em 45,17% (42 olhos. Em 15 olhos (16,1% ocorreu algum tipo de complicação: em 2 olhos (2,2% houve perda de células endoteliais, em 2 olhos (2,2% ocorreu bloqueio pupilar e em 11 olhos (11,8% houve alterações de transparência lenticular, assintomática em 5 olhos (5,4% e sintomática em 6 olhos (6,5%. Conclusão: O implante de lente fácica de câmara posterior para correção de miopia moderada e alta é um método eficaz, previsível e seguro. O significativo ganho de linhas de visão é uma observação freqüente nesta técnica. Um acompanhamento pós-operatório mais prolongado em um maior número de pacientes é necessário para confirmar a estabilidade dos resultados a longo prazo.Purpose: To examine the efficacy, predictability and safety of posterior chamber phakic intraocular lens implantation in patients with moderate and high myopia. Methods: We analyzed the results of 93 eyes of 54 patients who were submitted to the implantation of a posterior chamber phakic lens for the correction of their myopia. The target postoperative

  18. Meta-analysis of expression of l(3)mbt tumor-associated germline genes supports the model that a soma-to-germline transition is a hallmark of human cancers.

    Science.gov (United States)

    Feichtinger, Julia; Larcombe, Lee; McFarlane, Ramsay J

    2014-05-15

    Evidence is starting to emerge indicating that tumorigenesis in metazoans involves a soma-to-germline transition, which may contribute to the acquisition of neoplastic characteristics. Here, we have meta-analyzed gene expression profiles of the human orthologs of Drosophila melanogaster germline genes that are ectopically expressed in l(3)mbt brain tumors using gene expression datasets derived from a large cohort of human tumors. We find these germline genes, some of which drive oncogenesis in D. melanogaster, are similarly ectopically activated in a wide range of human cancers. Some of these genes normally have expression restricted to the germline, making them of particular clinical interest. Importantly, these analyses provide additional support to the emerging model that proposes a soma-to-germline transition is a general hallmark of a wide range of human tumors. This has implications for our understanding of human oncogenesis and the development of new therapeutic and biomarker targets with clinical potential. © 2013 The Authors. Published by Wiley Periodicals, Inc. on behalf of UICC.

  19. An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

    Science.gov (United States)

    Driver, Christine

    2005-04-01

    This paper explores the dynamics brought into analytic work when there is a symmetric fusion between psyche and soma within the patient. It will consider how such a fusion may emerge from reverberations between physical constitution and a lack of maternal attunement, containment and reflective function. I will describe the work with a patient, Jane, who was diagnosed with Myalgic Encephalomyelitis (ME) during the course of her analysis. The dynamic of her physical symptoms within the analytic work, and the impact of her internal affects and internal 'objects' within the transference and countertransference, indicated a difficulty in finding an homeostatic balance resulting in overactivity and underactivity at both somatic and psychological levels. Using the clinical work with Jane this paper will also examine the interrelationship between mother-infant attachment, an inadequate internalized maternal reflective function, affect dysregulation, unconscious fusion, the lack of psyche-soma differentiation and the impact of the latter in relation to internal regulation systems, or lack of, in patients with Chronic Fatigue Syndrome (CFS) and Myalgic Encephalomyelitis (ME). I will draw on similar work carried out by Holland (1997), Simpson (1997) and Simpson et al. (1997). The paper will also employ the concept of the reflective function (Fonagy 2001; Knox 2003), and consider Matte-Blanco's (1999) concepts of generalization and unconscious symmetry in relation to the patient's internal world. I go on to consider how analysis provides a point outside the 'fusion' that can enable the 'deadlock' to be broken.

  20. Efeito do filtro de ultravioleta em lentes de contato hidrofílicas de alta hidratação Ultraviolet filter effect on hydrophilic high hydrated contact lenses

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    Arlindo José Freire Portes

    2008-06-01

    Full Text Available A exposição à radiação ultravioleta está relacionada ao aparecimento de patologias oculares como ceratites, cataratas, degenerações maculares ou pterígio. Esta radiação está dividida em 3 tipos de acordo com o seu comprimento de onda: Uv-A (320-400nm, Uv-B (290-320nm e Uv-C (100-290nm. A indústria óptica desenvolveu filtros de ultravioleta para lentes intra-oculares, lentes de contato e lentes de óculos. OBJETIVO: Avaliar a eficácia do filtro de ultravioleta em lentes de contato de alta hidratação. MÉTODOS: Seis grupos de lentes de contato de alta hidratação e de marcas diferentes, contendo 3 unidades novas e iguais foram estudadas, observando-se o percentual de transmissão da energia luminosa de 200 a 400 nm através de um espectofotômetro. RESULTADOS: Os 3 grupos que apresentavam filtro de ultravioleta causaram uma queda abrupta na transmissão da radiação ultravioleta de 400 nm até 340 nm, ocorrendo um aumento na transmissão entre 240 a 300 nm até um nível máximo de 45%. Abaixo de 240 nm e entre 300 e 340 nm, houve um completo bloqueio da transmissão da radiação ultravioleta. Os 3 grupos que não apresentavam filtros de ultravioleta causaram uma queda abrupta na transmissão da radiação ultravioleta abaixo de 240 nm, ocorrendo um bloqueio completo de transmissão abaixo de 220 nm. CONCLUSÃO: As lentes de contato sem filtro Uv testadas não bloquearam com eficácia a radiação Uv-A, B ou C, e as com filtro bloquearam quase totalmente a radiação Uv-B e parcialmente a radiação Uv-A e Uv-C.The exposure to ultraviolet radiation is associated with the beginning of ocular pathologies like keratites, cataract, age-related macular degeneration and pterygium. This radiation is divided in 3 bands according to the wave length: Uv-A (320-400, Uv-B (290-320, Uv-C (100-290. The optic industry developed ultraviolet filters to intraocular lenses, contact lenses and spectacle lenses. PURPOSE: The issue of this work is

  1. Chronic rectal bleeding after high-dose conformal treatment of prostate cancer warrants modification of existing morbidity scales

    International Nuclear Information System (INIS)

    Hanlon, Alexandra L.; Schultheiss, Timothy E.; Hunt, Margie A.; Movsas, Benjamin; Peter, Ruth S.; Hanks, Gerald E.

    1997-01-01

    Purpose: Serious late morbidity (Grade (3(4))) from the conformal treatment of prostate cancer has been reported in <1% to 6% of patients based on existing late gastrointestinal (GI) morbidity scales. None of the existing morbidity scales include our most frequently observed late GI complication, which is chronic rectal bleeding requiring multiple fulgerations. This communication documents the frequency of rectal bleeding requiring multiple fulgerations and illustrates the variation in reported late serious GI complication rates by the selection of morbidity scale. Methods and Materials: Between May 1989 and December 1993, 352 patients with T1-T3 nonmetastatic prostate cancers were treated with our four-field conformal technique without special rectal blocking. This technique includes a 1-cm margin from the clinical target volume (CTV) to the planning target volume (PTV) in all directions. The median follow-up for these patients was 36 months (range 2-76), and the median center of prostate dose was 74 Gy (range 63-81). Three morbidity scales are assessed: the Radiation Therapy Oncology Group (RTOG), the Late Effects Normal Tissue Task Force (LENT), and our modification of the LENT (FC-LENT). This modification registers chronic rectal bleeding requiring at least one blood transfusion and/or more than two coagulations as a Grade 3 event. Estimates for Grade (3(4)) late GI complication rates were determined using Kaplan-Meier methodology. The duration of severe symptoms with chronic rectal bleeding is measured from the first to the last transrectal coagulation. Latency is measured from the end of radiotherapy to surgery, first blood transfusion, or third coagulation procedure. Results: Sixteen patients developed Grade (3(4)) complications by one of the three morbidity scales. Two patients required surgery (colostomy or sigmoid resection), three required multiple blood transfusions, two required one or two blood transfusions, and nine required at least three

  2. Avaliação da composição molecular da cápsula anterior da lente de cães idosos com catarata de alto risco

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    Ana Paula Hvenegaard

    Full Text Available Resumo: Atualmente, a cápsula anterior e o epitélio da lente tem sido cada vez mais estudados, com o intuito de reduzir as possíveis complicações do pós-operatório da remoção da catarata, tal como a opacidade da cápsula posterior, alteração ocasionada principalmente pela diferenciação e migração das células do epitélio lenticular para a cápsula posterior da lente. O objetivo deste estudo foi analisar a composição molecular da cápsula anterior da lente pela técnica histoquímica de PAS (avaliação de proteoglicanos e picrosirius red (avaliação de colágeno IV, em cães idosos com catarata diabética e não diabética do tipo hipermadura, submetidos ao uso ou não de azul de tripano a 0,1 % durante a facoemulsificação. Vinte e sete cães foram estudados, incluindo 21 fêmeas e 6 machos, de 8 a 12 anos de idade (média = 9,6 anos, de diversas raças e divididos em 2 grupos: GC (catarata hipermadura e GCD (catarata diabética. Os resultados das análises realizadas mostraram que ambas as amostras, tanto as provenientes das cataratas hipermaduras, quanto das diabéticas, apresentam semelhante composição molecular de proteoglicanos e colágeno IV e isto independente da utilização de azul de tripano a 0,1 %. Conclui-se, portanto, que se os resultados obtidos forem decorrentes de alterações provocadas pelo rápido metabolismo da catarata diabética e pela cronicidade da catarata hipermadura sugere-se que o comprometimento da estrutura capsular seja de intensidade equivalente e, por consequência, que isto também possa prejudicar o metabolismo das células do epitélio anterior da lente, diminuindo assim a incidência da opacidade da cápsula posterior de cães com catarata diabética e hipermadura submetidos à facoemulsificação.

  3. Avaliação da qualidade óptica de lentes de contato gelatinosas na correção de miopia Evaluation of optical performance of soft contact lenses in myopic correction

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    Marcelo Weslley Dalcoll

    2008-12-01

    Full Text Available OBJETIVO: Avaliar a qualidade óptica de olhos adaptados com dois tipos diferentes de lentes de contato gelatinosas: Acuvue® 2 (Vistacon J&J Vision Care Inc., EUA e World Vision Disposable Asférica Wave Front® (World Vision Ophthalmic, Brasil. MÉTODOS: Estudo clínico e prospectivo com intervenção em amostra constituída por 40 indivíduos portadores de miopia entre -0,75D e -4,50D, sem ou com astigmatismo até -0,75D. Um olho de cada paciente foi sorteado para avaliação a qual incluiu acuidade visual de alto e baixo contraste, aberrometria e teste de sensibilidade ao contraste. RESULTADOS: A sobre-refração objetiva realizada pelo Nidek OPD-Scan detectou hipercorreção significativa para ambas as lentes de contato gelatinosas. A avaliação da AV logMAR de alto e baixo contraste mostrou diferença significativa favorável das lentes de contato gelatinosas em relação aos óculos e na comparação entre as lentes de contato gelatinosas, apenas em relação à AV logMAR de alto contraste, houve melhor desempenho da LC World Vision Disposable Asférica Wave Front® . A avaliação de sensibilidade ao contraste detectou melhor desempenho das lentes de contato gelatinosas em relação aos óculos para as freqüências espaciais de 1,5; 3; 6 e 18. Não houve diferença significativa entre os dois tipos de lentes de contato gelatinosas nas freqüências espaciais avaliadas. A análise de frentes de onda não identificou diferença significativa do índice de Strehl, função de transferência modular (MTF e das aberrações de alta ordem (aberrações totais, coma, trefoil, quadrifoil, esférica e astigmatismo secundário sem e com as lentes de contato gelatinosas, bem como na comparação entre elas. CONCLUSÃO: Houve melhor desempenho óptico da lente de contato gelatinosa World Vision Disposable Asférica Wave Front® na medida de AV logMAR de alto contraste. Não houve diferença entre as lentes de contato gelatinosas nas avalia

  4. Bilateral Acanthamoeba ulcer in a user of disposable soft contact lenses: a tragic incident or a consequence of the aggressive policy of soft contact lens trading? Úlcera bilateral por Acanthamoeba em usuária de lentes de contato gelatinosas descartáveis: um incidente trágico ou uma conseqüência da política agressiva de venda de lentes de contato gelatinosas?

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    Sidney Júlio de Faria e Sousa

    2008-06-01

    Full Text Available This is the report of a case of bilateral Acanthamoeba keratitis in a 19-year-old woman who bought a pair of disposable soft contact lenses in a boutique. She wore this same pair of lenses for 3 months daily without the appropriate care. This led to bilateral corneal transplantation with cataract extraction and also trabeculectomy in the right eye. When last seen, both grafts were crystal clear but the visual acuities were far from satisfactory. She also had bilateral secondary glaucoma, barely controlled by topical medication. Actually, the physical features and the wearing time characteristics of the disposable soft contact lenses created unprecedented difficulties to the medical surveillance of their wearers. Without the right assistance they tend to become careless regarding routine cleaning. They also feel free to buy less expensive lenses, to use saline instead of lens solutions, to violate the limits of wearing time and to extend the use over the sleeping period. Additionally, the aggressive marketing and the wide distribution of these lenses increase the chances that economically or educationally unprepared people will acquire them. The question that remains is: Is the present case an accidental event or an example of what is likely to happen in the future if the indiscriminate selling of disposable soft contact lenses continues to evolve?Este é o relato de uma paciente do sexo feminino, de 19 anos, com ceratite bilateral por Acanthamoeba, devido ao uso de lentes de contato descartáveis, adquiridas em uma butique. Fez uso do mesmo par de lentes durante três meses, sem os cuidados adequados. Foi submetida a transplante penetrante de córnea e facectomia bilateral, além de trabeculectomia no olho direito. Quando vista pela última vez, os enxertos estavam transparentes, mas a visão de ambos os olhos não era satisfatória. Ela também apresentava glaucoma secundário bilateral, controlado precariamente com medicação tópica. Ocorre

  5. Development of a slow mono-kinetic electron source; Etude et realisation d'une source d'electrons lents monocinetiques

    Energy Technology Data Exchange (ETDEWEB)

    Ballu, Y [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-06-01

    A comparative study of already existing slow mono-kinetic electron guns shows that those using a 127 degrees electrostatic selector can be improved still further to arrive at the performances obtained with spherical 180 degrees selectors for example. For this reason we have examined the 127 degrees selector theoretically in more detail; it appears that it should be possible to obtain a resolving power better than 30 mV for a current of about 10{sup -10} A, on condition that certain improvements be made to the instrument as normally designed, in particular concerning the entrance and exit slides. As a result, the usual suppressors for the scattered electrons are no longer necessary. The development of this apparatus has been carried out with particular care: the dimensional characteristics are fixed to an accuracy of a few microns, although the instrument can be baked out at 300 C. The experimental results are in excellent agreement with the theoretical predictions: for a current of 10{sup -10} A, the measured resolving power is 24 {+-} 4 mV. The easy detection of the He{sup -} resonance line at 19.3 eV has confirmed the advantages of this apparatus for the study of atomic collisions. (author) [French] L'etude comparative des canons a electrons lents monocinetiques realises jusqu'a present montre que ceux qui utilisent un selecteur electrostatique a 127 degres peuvent etre encore perfectionnes en vue de parvenir aux performances obtenues avec les selecteurs spheriques a 180 degres par exemple. D'ou notre etude theorique approfondie du selecteur a 127 degres qui nous a conduit a esperer une resolution meilleure que 30 mV pour un courant de l'ordre de 10{sup -10} A a condition d'apporter certaines ameliorations a la conception usuelle de cet instrument notamment au niveau des fentes d'entree et de sortie. Par voie de consequence les suppresseurs habituels d'electrons parasites deviennent inutiles. L'etude et la mise au point de l'appareil ont fait l'objet de soins

  6. Estudo das capacidades organizacionais sob a lente da ambidestria: uma abordagem a partir do ponto de vista estratégico

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    Diego Jacob Kurtz

    2013-11-01

    Full Text Available O presente trabalho alinha-se à visão de que a criação de riqueza em regimes de rápida mudança depende em grande medida da capacidade de aperfeiçoar tecnologias, processos e a gestão interna da empresa. Isso é permitido na medida em que a organização equilibra suas capacidades referentes à eficácia e eficiência de suas operações (explotação àquelas ligadas às novas formas de negócio e exploração de oportunidades (exploração. O objetivo desta pesquisa consiste na realização de uma busca e análise sistemática da literatura que aborda as capacidades das organizações sob a lente da ambidestria e orientação estratégica em ambientes de elevada turbulência. A sessão de resultados apresenta as principais abordagens referentes às capacidades de exploração e explotação dos recursos e orientação estratégica. Apresenta-se também uma análise a respeito de como o ambiente modera e influencia a utilização desses recursos em contextos de rápida mudança e elevada instabilidade. Identificou-se que parte das pesquisas não expõe de forma clara a relação entre a ambidestria e outros constructos. Quando associados aos termos relacionados a ambientes turbulentos, muitas vezes são utilizados apenas de forma superficial, servindo somente de contexto para o estudo; em outras vezes, é abordado de forma mais ativa, sendo apresentado como moderador direto sobre as variáveis analisadas. Novos trabalhos devem considerar a ambidestria organizacional no curto prazo e suas respectivas implicações de desempenho no longo prazo. Existe ainda a necessidade de criar uma visão mais dinâmica de como organizações ambidestras adaptam-se às mudanças, considerando o impacto sobre a orientação estratégica em diferentes contextos. 

  7. Chronic rectal bleeding after high dose conformal treatment of prostate cancer warrants modification of existing morbidity scales

    International Nuclear Information System (INIS)

    Hanlon, A.L.; Schulthiess, T.E.; Hunt, M.A.; Movsas, B.; Peter, R.; Hanks, G.E.

    1996-01-01

    Purpose: Serious late morbidity (Grade (3(4))) from the conformal treatment of prostate cancer has been reported in <1% to 6% of patients. This study demonstrates that the reported frequency of Grade (3(4)) complications varies by the morbidity scale selected and that no existing morbidity scale adequately represents chronic rectal bleeding, which is our most frequent persisting late sequela of high dose conformal treatment. Materials and Methods: Between (5(89)) and (12(93)), 352 patients with T1-3 NXM0 prostate cancers were treated with our 4-field conformal technique without special rectal blocking. This technique includes a 1 cm margin from the CTV to the PTV in all directions. The median follow-up for these patients was 38 mos (4 to 78), and the median ICRU reporting point dose was 74 Gy (63 to 81). Patients are followed at six month intervals, and no patient is lost to follow-up. Three morbidity scales are assessed, the RTOG, the late effects group (LENT), and our modification of the LENT (FC-LENT). This modification registers chronic rectal bleeding requiring more than two coagulations as a grade 3 event. Estimates for Grade (3(4)) late GI complication rates were determined using Kaplan-Meier methodology. Differences in morbidity rates were evaluated using the log-rank test and differences in time to latency of complications were evaluated using the nonparametric Wilcoxon test. The duration of severe symptoms with chronic rectal bleeding is measured from the first to the last transrectal coagulation. Results: Sixteen patients developed Grade (3(4)) complications by one of the three morbidity scales. Two patients required surgery (colostomy, sigmoid resection), 5 required a transfusion, and 9 required more than two coagulations. The median latency to the third coagulation (plus or minus transfusions) was 24 mos (17 to 40). The median duration of bleeding between the first and last coagulation was 6 mos (3 to 25), illustrating the chronicity of this problem

  8. Desempenho visual após implante de uma lente intraocular asférica multifocal difrativa Visual performance after implantation of an aspheric multifocal diffractive intraocular lens

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    Leonardo Akaishi

    2010-08-01

    Full Text Available OBJETIVO: Avaliar a acuidade visual a distancia, intermediária e perto após o implante de uma lente intraocular (LIO asférica multifocal difrativa AcrySof® ReSTOR® SN6AD1. MÉTODOS: Estudo prospectivo de 50 pacientes com catarata submetidos à facoemulsificação e implante de LIO AcrySof® ReSTOR®. Foram avaliados acuidade visual sem correção (AVSC, acuidade visual com correção (AVCC para longe, acuidade visual para perto corrigida para longe (AVPC e acuidade visual intermediária corrigida para longe (AVIC. Um questionário de satisfação e fenômenos visuais foi administrado ao final do estudo. RESULTADO: Após três meses de cirurgia, a média das acuidades (logMAR era: AVSC, 0,05 ± 0,07; AVCC, 0,00 ± 0,01; AVPC, 0,00 ± 0,0, e AVIC, 0,15 ± 0,05. A AVCC e AVPC era de 20/25 ou melhor em todos os pacientes, sendo a AVIC J3 ou melhor em 83% dos pacientes. Pacientes relataram excelente desempenho visual nas questões relacionadas a atividades para distância, intermediário, e perto com pouca ou nenhuma dificuldade. Nenhum paciente relatou halos ou 'glare' severos, sendo os mesmos caracterizados entre nenhum a moderado. CONCLUSÃO: A LIO asférica AcrySof® ReSTOR® SN6AD1 mostrou excelentes resultados na visão para longe, perto e intermediário, além de apresentar uma baixa incidência de fenômenos visuais.PURPOSE: To evaluate distance, intermediate, and near vision after aspheric multifocal diffractive AcrySof® ReSTOR® SN6AD1 intraocular lens (IOL implantation. METHODS: Prospective study of 50 patients with cataract that had phacoemulsification and AcrySof® ReSTOR® IOL implantation. Uncorrected distance vision acuity (UDVA, corrected distance visual acuity (CDVA, distance-corrected near visual acuity (DCNVA, and distance-corrected intermediate visual acuity (DCIVA were measured postoperatively. A patient-satisfaction and visual phenomena questionnaire was administered at the end of the study. RESULTS: Three months

  9. Calidad visual en pacientes con lente intraocular multifocal modelo OcuFlex operados de catarata The quality of vision in patients operated on from cataract and implanted with OcuFlex multifocal intraocular lenses

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    Eneida Pérez Candelaria

    2010-01-01

    Full Text Available OBJETIVO: Describir la calidad visual en 8 pacientes operados de catarata bilateral con la técnica de Faco-chop e implante de lente intraocular multifocal modelo OcuFlex, en el ICO "Ramón Pando Ferrer", desde septiembre 2007 a febrero 2008. MÉTODOS: Se realizó un estudio observacional, descriptivo, longitudinal y prospectivo para lo cual se analizaron variables como equivalente esférico, sensibilidad al contraste en el preoperatorio y posoperatorio; fenómenos visuales, centrado y localización del lente intraocular, así como el estado de satisfacción subjetiva de los pacientes. Se utilizó la estadística descriptiva con ayuda del sistema Microsoft Excel y Word 2003, para Windows XP. RESULTADOS: El equivalente esférico medio posoperatorio fue -0,59 tanto para frecuencias bajas como medias, en visión binocular la sensibilidad al contraste media fue de 1,12 unid.log en el preoperatorio y de 1,74 unid.log. en el posoperatorio. Por biomicroscopia con lámpara de hendidura en el 100 % de los casos el lente intraocular estaba centrado y por biomicroscopia ultrasónica el 93,75 % se encontraba en el saco capsular. Ningún paciente refirió la presencia de glare y solamente uno (12,5 % reportó visión de halos nocturnos. La totalidad de los pacientes se manifestaron satisfechos. CONCLUSIONES: Los lentes multifocales disminuyen la dependencia de las gafas después de la cirugía de catarata, razón por la que constituye una buena opción en la recuperación de la función visual óptima.OBJECTIVE: To describe the quality of vision in 8 patients, who were operated on from bilateral cataract using Phaco-chop technique and implanted with Ocuflex multifocal intraocular lens in "Ramón Pando Ferrer" Cuban Institute of Ophthalmology from September 2007 to February 2008. METHODS: A prospective, longitudinal, observational and descriptive study was made in which the variables spheral equivalent, contrast sensitivity in the pre- and post

  10. Personalización de las constantes en las fórmulas de cálculo de la lente intraocular Personalization of constants in the intraocular lens calculation formulas

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    Anneé Miranda Carracedo

    2012-12-01

    Full Text Available Objetivo: personalizar las constantes A, factor cirujano y profundidad de la cámara anterior para las fórmulas de cálculo de la lente intraocular en la cirugía de catarata en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer" de mayo de 2007 a enero de 2011. Métodos: se realizó un estudio descriptivo retrospectivo donde se estudiaron las constantes A, factor cirujano y profundidad de la cámara anterior. También se evaluó la longitud axial preoperatoria por IOL Master, la mejor agudeza visual sin corrección, el componente esférico esperado, el componente esférico obtenido y los resultados refractivos. Resultados: las constantes optimizadas por interferometría de coherencia parcial son diferentes a las propuestas por los fabricantes de las lentes intraoculares. Estas constantes personalizadas para cada cirujano no mostraron diferencias significativas. Las constantes optimizadas según las longitudes axiales, tienen diferencias significativas en los 3 grupos de estudio. La diferencia entre la lente intraocular implantada y la propuesta con las nuevas constantes resultó menor de 1 D de error en 83,1 % de los pacientes. El 75,4 % quedó bien corregido en relación con la diferencia entre la refracción esperada y la obtenida. Conclusiones: las constantes optimizadas por interferometría de coherencia parcial resultan más elevadas que las propuestas por el fabricante. La optimización de estas en el cálculo de la lente permite, de acuerdo a las características individuales de cada ojo (longitud axial, usar la fórmula adecuada e incrementa la predictibilidad de los resultados refractivos posoperatorios.Objective: to personalize the A, surgeon factor and anterior chamber depth constants for intraocular lens calculation formulas in the cataract surgery at the “Ramón Pando Ferrer” Cuban Ophthalmological Institute from May 2007 to January 2011. Method: a retrospective and descriptive study was made to study the A constant

  11. Effect of aspherical and yellow tinted intraocular lens on blue-on-yellow perimetry Efeito das lentes intraoculares asféricas e com pigmentação amarela na campimetria azul-amarelo

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    Rodrigo França de Espíndola

    2012-10-01

    Full Text Available PURPOSE: To investigate the possible effect of aspherical or yellow tinted intraocular lens (IOL on contrast sensitivity and blue-on-yellow perimetry. METHODS: This prospective randomized bilateral double-masked clinical study included 52 patients with visually significant bilateral cataracts divided in two groups; 25 patients (50 eyes received aspherical intraocular lens in one eye and spherical intraocular lens in the fellow eye; and 27 patients (54 eyes received ultraviolet and blue light filter (yellow tinted IOL implantation in one eye and acrylic ultraviolet filter IOL in the fellow eye. The primary outcome measures were contrast sensitivity and blue-on-yellow perimetry values (mean deviation [MD] and pattern standard deviation [PSD] investigated two years after surgery. The results were compared intra-individually. RESULTS: There was a statistically significant between-group (aspherical and spherical intraocular lens difference in contrast sensitivity under photopic conditions at 12 cycles per degree and under mesopic conditions at all spatial frequencies. There were no between-group significant differences (yellow tinted and clear intraocular lens under photopic or mesopic conditions. There was no statistically significant difference between all intraocular lens in MD or PSD. CONCLUSION: Contrast sensitivity was better under mesopic conditions with aspherical intraocular lens. Blue-on-yellow perimetry did not appear to be affected by aspherical or yellow tinted intraocular lens. Further studies with a larger sample should be carried out to confirm or not that hypotheses.OBJETIVO: Investigar a possibilidade de efeitos na sensibilidade ao contraste e nos resultados da campimetria azul-amarelo com implante de uma lente intraocular (LIO asférica ou de pigmentação amarela. MÉTODOS: Trata-se de um estudo prospectivo, randomizado, duplo-mascarado, envolvendo 52 pacientes portadores de catarata senil bilateral, divididos em dois grupos; 25

  12. Subluxação congênita do cristalino: resultados visuais e posição das lentes intraoculares após a cirurgia Congenital lens subluxation: visual acuity outcomes and intraocular lens postoperative position

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    Caroline Arraes

    2010-04-01

    Full Text Available OBJETIVO: Avaliar os resultados visuais e investigar, através da biomicroscopia ultrassônica, o posicionamento das lentes intraoculares e do anel endocapsular em 17 olhos de 10 portadores de subluxação congênita do cristalino, submetidos à mesma técnica cirúrgica pelo mesmo cirurgião. MÉTODOS: O estudo foi realizado no Hospital de Olhos de Pernambuco e Fundação Altino Ventura. A técnica cirúrgica consistiu em facoaspiração com implante de anel endocapsular e de lentes intraoculares com amputação de uma das alças. A idade variou entre 7 e 22 anos. Foram coletados dados sobre acuidade visual para longe pré e pós-operatória, tempo de seguimento após a cirurgia e complicações. Os pacientes foram submetidos à biomicroscopia ultrassônica. RESULTADOS: O tempo de seguimento médio foi de 2,8 anos. Houve melhora da acuidade visual para longe nos 17 (100% olhos: 12 olhos (70,6% apresentaram acuidade visual para longe melhor que 20/40; 4 (23,5% apresentaram acuidade visual para longe entre 20/40 e 20/100 e 1 (5,9% apresentou acuidade visual para longe pior que 20/100, porém melhor que acuidade visual para longe pré-operatória. A opacificação da cápsula posterior ocorreu em 10 olhos (58,9%. Na biomicroscopia ultrassônica observou-se que todas as lentes intraoculares estavam parcialmente descentralizadas, contudo sem atingir o bordo pupilar. Em todos os casos observou-se um adequado posicionamento do anel e um bom suporte capsular. CONCLUSÃO É possível concluir que o tratamento cirúrgico avaliado proporciona uma boa centralização das lentes intraoculares e do anel endocapsular, com melhora da acuidade visual para longe, sendo uma opção viável, eficaz e segura na reabilitação visual dos pacientes com subluxação congênita do cristalino.PURPOSE: To evaluate the visual acuity outcomes and to investigate the intraocular lens (IOL and endocapsular ring positions with ultrasound biomicroscopy in 17 eyes of 10 patients

  13. Efectividad de los lentes fáquicos Artisan en la corrección de la alta miopía Effectiveness of Artisan phakic lenses in the correction of high myopia

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    Yanele Ruiz Rodríguez

    2010-12-01

    Full Text Available OBJETIVO: Determinar la efectividad de los lentes intraoculares fáquicos Artisan en la corrección de la alta miopía en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer" en el período de enero del 2006 a enero del 2009. MÉTODOS: Se realizó un estudio prospectivo, descriptivo. El universo estuvo constituido por el total de ojos (120 a los cuales se les implantó estos lentes. RESULTADOS: Se encontró un componente esférico de 0,5, no astigmatismo inducido y una mejoría de la agudeza visual corregida de 0,9. No se presentaron complicaciones transoperatorias y entre las posoperatorias mediatas predominó la iritis o uveítis (3,4 % así como la atrofia iridiana (5 % entre las tardías. CONCLUSIONES: Los resultados refractivos fueron favorables. Predominaron los pacientes sin complicaciones.OBJECTIVE: To determine the effectiveness of Artisan phakic intraocular lenses in correcting high myopia at "Ramón Pando Ferrer" Cuban Institute of Ophthalmology in January 2006 to January 2009 period. METHODS: A prospective descriptive study was made in which the universe of study was 120 eyes implanted with this type of lenses. RESULTS: Spheral component of 0.5; the induced astigmatism was not found and the corrected visual acuity improvement was 0.9. There were no transoperative complications; the predominant postoperative mediate complications were iritis or uveitis (3.4 % and iridic atrophy (5 % prevailed in the late ones. CONCLUSIONS: The refractive results were favourable. The uncomplicated patients predominated.

  14. Ceratocone: correlação entre grau evolutivo e padrão topográfico com o tipo de lente de contato adaptada Keratoconus: correlation between degrees of severity and topographical pattern with the kind of fitted contact lens

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    Vinícius Coral Ghanem

    2003-01-01

    Full Text Available OBJETIVO: Verificar a existência de associações entre grau evolutivo e padrão topográfico do ceratocone com as lentes de contato (LC adaptadas. MÉTODOS: Estudo retrospectivo do tratamento de 454 pacientes (881 olhos com ceratocone, 746 adaptados com lentes de contato, de julho de 1996 a junho de 2000. Classificou-se o ceratocone segundo grau evolutivo e padrão topográfico. A primeira lente de contato testada foi rígida gás-permeável (RGP monocurva. Quando não se alcançou a adaptação desejada, testou-se as rígidas gás-permeáveis bicurvas e outros desenhos, procurando-se relação lente-córnea com livramento apical ou discreto toque apical. Em caso de insucesso com as rígidas foram testadas as lentes de contato gelatinosas, esféricas, tóricas e com desenhos especiais. RESULTADOS: Para 15 (3,3% pacientes foram receitados óculos; 111 olhos (12,6% permaneceram sem correção; 746 (84,68% olhos foram adaptados com LC; 39 olhos (4,44% de 39 pacientes (8,6% foram encaminhados para transplante de córnea. O grau evolutivo mais encontrado foi o avançado (575 olhos - 66,86%, seguido do incipiente (160 olhos - 18,6%. O valor ceratométrico médio do meridiano mais plano (K foi de 47,80 (±3,73 para os olhos adaptados com lentes de contato gelatinosas; de 49,03 (±3,7 para as lentes de contato rígidas gás-permeáveis monocurvas; de 51,62 (±3,6 para as lentes de contato bicurvas e de 51,14 (±3,5 para o sistema "piggyback". Quanto à classificação topográfica, o mais freqüente foi o periférico inferior (436 olhos - 50,7%, seguido pelo central assimétrico (348 olhos - 40,46%. No olho direito, a análise das variáveis padrão topográfico e tipo de lente adaptada demonstrou associação estatisticamente significante (p=0,045 de lentes de contato gelatinosas tóricas e sistema "piggyback" com percentual maior de adaptações nos ceratocones centrais. Com as lentes de contato rígidas gás-permeáveis monocurvas e bicurvas houve

  15. T.i.d. radiotherapy with or without alternating chemotherapy in patients with a locally advanced squamous cell carcinoma of the head or neck: an analysis of late toxicity

    International Nuclear Information System (INIS)

    Laszlo, A.; Rosset, A.; Ozsahin, M.; Zouhair, A.; Mirimanoff, R.O.; Laszlo, A.; Hermann, F.

    2001-01-01

    To assess late effects and quality of life in patients treated by three times daily (t.i.d.) radiotherapy with or without alternating chemotherapy for locally advanced squamous cell carcinoma of the head and neck. Between 1986 and 1991, 153 patients with locally advanced tumors have been included in a phase I/II study consisting of t.i.d. radiotherapy (4 h. between fractions) of 2 Gy/fraction to a total dose of 60 Gy, alternated or not with combination chemotherapy. The first group of patients received radiotherapy alone, the other group received combined modality. Ninety-two patients were eligible for late effect assessment: 61 in the combined modality group and 31 in the radiation therapy only group. The median follow-up was 45 months. All patients have been assessed according to the follow-up clinical records using the RTOG/EORTC classification. Twenty-nine patients, who were alive at the time of our study, received a questionnaire on their quality of life, and were invited for a clinical evaluation using the SOMA-LENT scale. Ninety percent of the patients treated by radiation therapy alone developed one or more late complications. Overall, 47% of the patients have developed severe complications (grade III and IV): 42% in the group treated by radiation therapy alone and 49% in the group treated with combined modality. In the group treated by radiation therapy alone, the most commonly damaged organs were the mucosa (83%), skin (51%) and salivary glands (42%). We observed one case of osteonecrosis and one case of radiation myelitis. In the combined modality group, 95% of patients developed one or more late sequelae, of which 79% had skin, 51% mucosa and 42% salivary gland late effects, respectively. We observed four cases of osteonecrosis. Quality of life and overall physical condition of the patients have been judged to be average by self-questionnaire. Assessment according to the SOMA-LENT scale showed serious late effects mainly at the level of the salivary

  16. Comparison between OPD-Scan results and visual outcomes of monofocal and multifocal intraocular lenses Comparação dos resultados do OPD-Scan e performance visual das lentes intraoculares monofocal e multifocal

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    Wilson Takashi Hida

    2009-08-01

    Full Text Available PURPOSE: To compare the visual outcome, contrast sensitivity and wavefront analysis of patients that underwent cataract surgery and implantation of AcrySof SN60D3 multifocal intraocular lens with those who received the AcrySof SN60AT monofocal IOL. METHODS: This was a prospective clinical trial of forty eyes that received the multifocal IOL and thirty-two eyes that received the monofocal IOL after phacoemulsification. RESULTS: Values for total and spherical aberrations in the multifocal group were statistically lower than in the monofocal group. In the monofocal group, 75% achieved uncorrected intermediate visual acuities between Jaeger 1 and 6. In the multifocal group, 75% of the eyes achieved more than Jaeger 6. At least 87.5% of the multifocal group and 6.3% of the monofocal group achieved monocular uncorrected near acuity of 20/30 (J2, N5 or better. And 90.0% of the eyes in the multifocal group and 37.5% in the monofocal group achieved an uncorrected near acuity of 20/40 (J3, N6 or better. The mean spherical error was 0.11 D in the multifocal group and -0.18 D in the monofocal group (p=0.0379. The SN60D3 group compared to SN60AT group had low contrast sensitivity (log units with statistically significant differences in 6.0 cpd in photopic conditions (p=0.014 and the SN60D3 group compared to SN60AT group had higher contrast sensitivity (log units under mesopic conditions (p=0.044. CONCLUSION: The multifocal IOLs induced less spherical aberration than monofocal IOLs and predictably good uncorrected distance and uncorrected near acuities. However, contrast sensitivity was lower in the multifocal group.OBJETIVO: Comparar a performance visual, sensibilidade ao contraste e de wavefront com OPD-Scan em pacientes submetidos a cirurgia de facoemulsificação com implante de lente intraocular AcrySof SN60D3 multifocal e AcrySof SA60AT monofocal. MÉTODOS: Quarenta olhos com a lente intraocular multifocal e trinta e dois olhos com a lente intraocular

  17. Facoemulsificação, vitrectomia via pars plana e implante de lente intra-ocular em olhos com retinopatia diabética proliferativa Phacoemulsification, pars plana vitrectomy and intraocular lens implant in eyes with proliferative diabetic retinopathy

    Directory of Open Access Journals (Sweden)

    Armando Belfort Mattos

    2004-06-01

    Full Text Available OBJETIVO: Avaliar a viabilidade da técnica de facoemulsificação para a extração da catarata com implante de lente intra-ocular combinada à vitrectomia via pars plana em olhos com retinopatia diabética proliferativa, em um único procedimento cirúrgico. MÉTODOS: Foram revisados os prontuários de 47 pacientes (53 olhos com retinopatia diabética proliferativa e catarata que foram submetidos ao procedimento combinado de vitrectomia via pars plana, facoemulsificação e implante de lente intra-ocular no mesmo ato cirúrgico, entre janeiro de 1991 e setembro de 1998 no Bascom Palmer Eye Institute, hospital de olhos filiado à Universidade de Miami. O estudo foi realizado em conjunto com a Universidade Federal de São Paulo. Participaram do estudo 43 olhos de 40 pacientes. RESULTADOS: O tempo de seguimento variou de três a 60 meses com média de 20 meses. A idade dos pacientes variou de 37 a 77 anos com média de 59 anos. A acuidade visual melhorou duas linhas ou mais em relação ao pré-operatório em 26 (60,4% olhos, permaneceu a mesma em 9 (20,9% e piorou em 8 (18,6%. Em (23,2% 10 olhos a acuidade visual aumentou para 20/40. O teste estatístico chamado de "teste do sinal" mostrou-se estatisticamente significante na melhora da acuidade visual final. A complicação mais observada foi a hemorragia vítrea recorrente, ocorrendo em 12 (27,9% olhos, seguida pela inflamação transitória da câmara anterior em 9 olhos (20,9%. Complicações intra-operatórias relacionadas à extração do cristalino foram raras. No pós-operatório observaram-se captura da lente intra-ocular em 2 (4,6 % olhos e lente intra-ocular subluxada em 1 (2,3% olho. CONCLUSÕES: A cirurgia combinada de facoemulsificação, implante de lente intra-ocular e vitrectomia via pars plana em olhos com retinopatia diabética é procedimento bem tolerado e geralmente apresenta bons resultados com relação à acuidade visual. Um único procedimento para remover a catarata e

  18. Avaliação da sensibilidade ao contraste e da estereopsia em pacientes com lente intra-ocular multifocal Contrast sensitivity and stereopsis in pseudophakic patients with multifocal intraocular lens

    Directory of Open Access Journals (Sweden)

    Filipe de Oliveira

    2005-08-01

    Full Text Available OBJETIVO: Avaliar a sensibilidade ao contraste e a acuidade estereoscópica em pacientes pseudofácicos, que receberam implante bilateral de lente intra-ocular multifocal. MÉTODOS: Prospectivamente foram realizados testes de sensibilidade ao contraste com o uso da tabela Pelli-Robson e teste de acuidade estereoscópica com emprego do Titmus Stereo Test, em 20 pacientes com implante bilateral de lente intra-ocular multifocal Acrysof Restor®, no pós-operatório de 1 a 2 meses e sem uso de qualquer correção óptica. RESULTADOS:O teste de sensibilidade ao contraste binocular demonstrou que 6 pacientes (30% apresentaram 1,80 unid. log, 13 (65% 1,65 e 1 (5% 1,50. No teste monocular, ocorreram as seguintes respostas: 17 pacientes (85% 1,65 unid. log e 3 (15% 1,50 para o teste do olho direito. O teste do olho esquerdo mostrou que 16 pacientes (80% apresentaram 1,65 unid. log e 4 (20% 1,50. A média e o desvio-padrão da sensibilidade ao contraste testada binocularmente foi 1,69 (±0,08, ao passo que monocularmente foi 1,63 (±0,05 para OD e 1,62 (±0,06 para OE. O teste de acuidade estereoscópica revelou que 12 pacientes (60% obtiveram 40", 6 (30% 50" e 2 (10% 60", com média de 45" e desvio-padrão de ±6,88". CONCLUSÃO: A lente intra-ocular empregada no estudo, proporcionou resultados de sensibilidade ao contraste e acuidade estereoscópica compatíveis e de acordo com critérios de normalidade estabelecidos anteriormente por outros estudos em grupos de pacientes fácicos e pseudofácicos, e portanto, impacto positivo na funcionalidade visual.PURPOSE: To evaluate the contrast sensitivity and stereopsis tests in patients who underwent bilateral implantation of multifocal intraocular lens. METHODS: Tests of contrast sensitivity using the Pelli-Robson chart and stereopsis evaluation with the Titmus Stereo Test were performed in 20 patients 30-60 days after the bilateral implantation of Acrysof Restor® multifocal intraocular lens. RESULTS: The

  19. Analysis of dose volume histogram parameters to estimate late bladder and rectum complications after high-dose (70-78 Gy) conformal radiotherapy for prostate cancer

    International Nuclear Information System (INIS)

    Boersma, L.J.; Brink, M. van den; Bruce, A.; Gras, L.; Velde, A. te; Lebesque, J.V.

    1997-01-01

    GI complications ≥ grade II (RTOG/EORTC or SOMA/LENT). The actuarial incidence at 2 years for these scoring systems was similar, 14% and 19% respectively. For rectal bleeding no cut-off level was able to discriminate between high and low risk. However, for severe rectal bleeding (actuarial incidence at 2 years 3%), four volume cut-off levels were found, which significantly discriminated between high and low risk (Fig). A trend was observed that patients with a prescribed radiation dose ≥ 74 Gy (and consequently a maximum radiation dose in the rectal wall > 75 Gy) had a higher incidence of severe rectal bleeding than patients with a lower radiation dose (p = 0.07). None of the DVH parameters of the bladder wall was significantly correlated with the actuarial incidence of GU complications (RTOG/EORTC and SOMA/LENT). However, a marked difference was observed between the two scoring systems. Using the SOMA/LENT score GU toxicity was shifted towards more severe grades of complications (incidence of grade II and ≥ III, 41% and 23%, respectively), compared to the RTOG/EORTC scale (18% and 9%). After exclusion of the criterium urinary frequency in the SOMA/LENT scale, these figures were both 9%, indicating the disproportionate heavy weight of urinary frequency in the SOMA/LENT system. Conclusion: These data show that dose-escalation up to 78 Gy, using a conformal technique, is feasible. However, these data have demonstrated that the incidence of severe late rectal bleeding is increased above certain dose volume thresholds. This means that further dose-escalation should be performed with caution

  20. Distribution of radioactive "1"3"7Cs and "1"3"4Cs in river water and bottom sand for major rivers at Minami-Soma City in Fukushima

    International Nuclear Information System (INIS)

    Kajimoto, Tsuyoshi; Endo, Satoru; Shizuma, Kiyoshi; Naganuma, Takeshi

    2012-01-01

    A nuclear power plant accident, which occurred on March 11, 2011, caused severe radioactive contamination in Fukushima. We initiated an environmental radioactive survey in Minami-Soma City the following October. The city is located approximately 10-40 km north of the TEPCO's Fukushima Daiichi Nuclear Power Plant. The study reported here involves an environmental radioactive survey conducted along three rivers and their tributary streams.Water and bottom sands were collected from four to six sampling locations along each river. Water samples (1 L) were dried on thin Teflon sheets, and gamma-ray measurements were performed with a well-type Ge detector. Sand samples were homogenized after drying, and approximately 50 g were measured for gamma-rays with a low-background coaxial-type Ge detector. The Cs concentrations ("1"3"7Cs+"1"3"4Cs) were determined to be 10,000-20,000 Bq/kg in the bottom sand collected from the upper reaches of the rivers, whereas the concentrations measured from samples collected near coastal down reaches were measured at about 200 Bq/kg. The Cs concentrations measured in river water were about 0.8 Bq/L in the upper reaches of the rivers and 0.3 Bq/L in the lower reaches, indicating that the Cs concentration in water is quite low. It is necessary to study the behavior of the contaminants in the upper reaches of the river system, and determine if they will move to the down stream area hereafter. (author)

  1. Distribution of radioactive "1"3"7Cs and "1"3"4Cs in river water and bottom sand for major rivers at Minami-Soma City in Fukushima

    International Nuclear Information System (INIS)

    Kajimoto, Tsuyoshi; Endo, Satoru; Shizuma, Kiyoshi; Naganuma, Takeshi

    2013-01-01

    A nuclear power plant accident, which occurred on March 11, 2011, caused severe radioactive contamination in Fukushima. We initiated an environmental radioactive survey in Minami-Soma City the following October. The city is located approximately 10-40 km north of the TEPCO's Fukushima Daiichi Nuclear Power Plant. The study reported here involves an environmental radioactive survey conducted along three rivers and their tributary streams. Water and bottom sands were collected from four to six sampling locations along each river. Water samples (1 L) were dried on thin Teflon sheets, and gamma-ray measurements were performed with a well-type Ge detector. Sand samples were homogenized after drying, and approximately 50 g were measured for gamma-rays with a low-background coaxial-type Ge detector. The Cs concentrations ("1"3"7Cs+"1"3"4Cs) were determined to be 10,000-20,000 Bq/kg in the bottom sand collected from the upper reaches of the rivers, whereas the concentrations measured from samples collected near coastal down reaches were measured at about 200 Bq/kg. The Cs concentrations measured in river water were about 0.8 Bq/L in the upper reaches of the rivers and 0.3 Bq/L in the lower reaches, indicating that the Cs concentration in water is quite low. It is necessary to study the behavior of the contaminants in the upper reaches of the river system, and determine if they will move to the down stream area hereafter. (author)

  2. Comparação da função visual e do índice de qualidade de vida com uso de óculos ou de lente de contato progressiva Comparative analysis of visual function and the quality of life index with eyeglasses or a progressive contact lens

    Directory of Open Access Journals (Sweden)

    Neusa Vidal Sant'Anna

    2006-06-01

    Full Text Available OBJETIVO: Comparar a função visual e a resposta dos pacientes ao índice de qualidade de vida quando estes são corrigidos com óculos com lentes progressivas ou lente de contato progressiva. MÉTODOS: Foram selecionados 35 pacientes présbitas, usuários de óculos com acuidade visual igual, ou melhor, a logMAR zero (longe e J1 (perto, para adaptarem a lente de contato Focus Progressive®. Foram comparadas medidas de acuidade visual para longe, perto e sensibilidade ao contraste com a lente de contato e com os óculos. Os resultados do questionário de avaliação de qualidade de vida NEI VFQ-25 dos mesmos pacientes corrigidos com os óculos e com a lente de contato progressiva foram comparados, levando-se em consideração o tipo de ametropia e a idade. RESULTADOS: A acuidade visual para longe, perto e a sensibilidade ao contraste foram significantemente piores com lente de contato progressiva do que com os óculos. As respostas do questionário não diferiram quanto à forma de correção quando se analisou o tipo de ametropia, entretanto foram significantemente piores com a lente de contato nos grupos míope e hipermétrope abaixo das suas respectivas medianas da idade e maiores no hipermétrope acima de sua mediana. CONCLUSÃO: As funções visuais foram significantemente piores com a lente de contato e o tipo de ametropia não influenciou nas respostas ao índice de qualidade de vida quanto à forma de correção, mas sim, quanto à idade.PURPOSE: To compare the visual function and the answers to a questionnaire of quality of life of patients wearing a progressive contact lens or eyeglasses. METHODS: The Focus Progressive® contact lens had been fitted in 35 patients with far visual acuity with progressive-addition eyeglasses equal to zero (log MAR and near J1 (Jaeger. The far and near visual acuities and the measurement of contrast sensitivity were compared when the patients were wearing the eyeglasses or the contact lens and the

  3. Protection of Salivary Function by Concomitant Pilocarpine During Radiotherapy: A Double-Blind, Randomized, Placebo-Controlled Study

    International Nuclear Information System (INIS)

    Burlage, Fred R.; Roesink, Judith M.; Kampinga, Harm H.; Coppes, Rob P.; Terhaard, Chris; Langendijk, Johannes A.; Luijk, Peter van; Stokman, Monique A.; Vissink, Arjan

    2008-01-01

    Purpose: To investigate the effect of concomitant administration of pilocarpine during radiotherapy for head-and-neck squamous cell carcinoma (HNSCC) on postradiotherapy xerostomia. Methods and Materials: A prospective, double blind, placebo-controlled randomized trial including 170 patients with HNSCC was executed to study the protective effect of pilocarpine on radiotherapy-induced parotid gland dysfunction. The primary objective endpoint was parotid flow rate complication probability (PFCP) scored 6 weeks, 6 months, and 12 months after radiotherapy. Secondary endpoints included Late Effects of Normal Tissue/Somatic Objective Management Analytic scale (LENT SOMA) and patient-rated xerostomia scores. For all parotid glands, dose-volume histograms were assessed because the dose distribution in the parotid glands is considered the most important prognostic factor with regard to radiation-induced salivary dysfunction. Results: Although no significant differences in PFCP were found for the two treatments arms, a significant (p = 0.03) reduced loss of parotid flow 1 year after radiotherapy was observed in those patients who received pilocarpine and a mean parotid dose above 40 Gy. The LENT SOMA and patient-rated xerostomia scores showed similar trends toward less dryness-related complaints for the pilocarpine group. Conclusions: Concomitant administration of pilocarpine during radiotherapy did not improve the PFCP or LENT SOMA and patient-rated xerostomia scores. In a subgroup of patients with a mean dose above 40 Gy, pilocarpine administration resulted in sparing of parotid gland function. Therefore, pilocarpine could be provided to patients in whom sufficient sparing of the parotid is not achievable

  4. Trichostrongylina (Nematoda, Heligmosomoidea coparasites in Dasyprocta fuliginosa Wagler (Rodentia, Dasyproctidae from Brazil, with the re-establishment of the genus Avellaria Freitas & Lent and the description of two new species Trichostrongylina (Nematoda, Heligmosomoidea co-parasitos em Dasyprocta fuliginosa Wagler (Rodentia, Dasyproctidae do Brasil, com o restabelecimento do gênero Avellaria Freitas & Lent e a descrição de duas novas espécies

    Directory of Open Access Journals (Sweden)

    Marie C. Durette-Desset

    2006-06-01

    Full Text Available Two new tichostrongylid nematodes of the family Viannaiidae Durette-Desset & Chabaud, 1981 coparasites in Dasyprocta fuliginosa Wagler, 1832 from the State of Amazonas, Brazil, are described: Viannella trichospicula sp. nov. is differentiated from the other species of the genus by the extreme slenderness of its spicules. Avellaria intermedia sp. nov. is distinguished from the single type species Avellaria avellari Freitas & Lent, 1934, by a smaller number of cuticular ridges (17 versus 27, a higher ratio of spicule length/ body length (8% versus 5.6% and spicules with a single tip. This genus, synonymized with the genus Viannella Travassos, 1918, by Durette-Desset (1968 is re-established, the female being didelphic. It is the first record of a nematode of the family Viannaiidae in a host of the family Dasyproctidae Bonaparte, 1838.Dois novos nematóides tricostrongilídeos da família Viannaiidae Durette-Desset & Chabaud, 1981 co-parasitos em um espécime de Dasyprocta fuliginosa Wagler, 1832 do Estado do Amazonas, Brasil, são descritos: Viannella trichospicula sp. nov. distingue-se das espécies do gênero, pelos espículos extremamente delgados. Avellaria intermedia sp. nov. diferencia-se da espécie tipo e única do gênero Avellaria avellari Freitas & Lent, 1934, pelo menor número de arestas cuticulares (17 comparado a 27, pela maior relação entre o tamanho do espículo e o comprimento do corpo (8% comparado a 5,6% e espículos com extremidade única. Este gênero, que havia sido considerado sinônimo de Viannella Travassos, 1918, por Durette-Desset (1968, é restabelecido; as fêmeas são didelfas. Este é o primeiro registro de um nematóide da família Viannaiidae em um hospedeiro da família Dasyproctidae Bonaparte, 1838.

  5. Resultados preliminares do implante de lente intra-ocular fácica artisan para correção de miopia Preliminary results of artisan phakic intraocular lens implantation to correct myopia

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    Leonardo Akaishi

    2007-06-01

    Full Text Available OBJETIVOS: Avaliar os resultados preliminares quanto à eficácia, estabilidade e segurança da lente intra-ocular de câmara anterior Artisan em olhos fácicos para correção de miopia. MÉTODOS: Foi analisado retrospectivamente o resultado de 34 olhos fácicos que receberam o implante de lente intra-ocular Artisan para correção de miopia. Os parâmetros avaliados foram: contagem endotelial pré e pós-operatória, acuidade visual sem correção pré e pós-operatória, melhor acuidade visual com correção pré e pós-operatória, equivalente esférico pré e pós-operatório, ganho e perda de linhas de visão e complicações. RESULTADOS: Dezoito pacientes (34 olhos foram incluídos neste estudo. Quatorze eram do sexo feminino (77,8% e 4 do sexo masculino. A idade média dos pacientes era de 30 anos (DP ± 7,3, variando de 21 a 46 anos. O período médio de seguimento foi de 8,5 meses (DP ± 3,6. A média de perda endotelial foi de 4,75% em 6 meses. A acuidade visual sem correção pré-operatória era de 0,02 (20/800 variando de 0,01 a 0,13. O equivalente esférico médio pré-operatório na refração dinâmica era de -13,25 D, variando de -5,75 D a -19,75 D. No último seguimento a acuidade visual sem correção era de 0,64 (20/32 variando de 0,33 a 1,00. O equivalente esférico médio na refração dinâmica era de -1,18 D (DP ± 0,92 variando de + 0,25 a -3,0. Entre as complicações observadas em nosso estudo 1 (3,4% paciente apresentou deslocamento da lente por trauma necessitando de uma segunda intervenção para reposicionamento. CONCLUSÃO: O uso de lente fácica de câmara anterior Artisan para correção de miopia no presente estudo se mostrou seguro, eficaz e com boa previsibilidade. No entanto, estudo prospectivo com maior número de casos e maior seguimento é necessário para determinar a segurança do procedimento a longo prazo.PURPOSE: To observe the preliminary results based on the efficacy, stability and safety of

  6. Does the apodized diffractive intraocular lens Acrysof ReSTOR NaturalTM interfere with FDT Matrix perimetry results? A lente difrativa apodizada Acrysof ReSTOR NaturalTM pode interferir nos resultados da perimetria por FDT Matrix?

    Directory of Open Access Journals (Sweden)

    Karine Duarte Bojikian

    2009-12-01

    Full Text Available PURPOSE: To compare the effect of an apodized diffractive intraocular lens (IOL (Acrysof ReSTOR NaturalTM and its yellow counterpart (Natural IQ TM on frequency doubling technology (FDT perimetry results. METHODS: This study included 37 eyes from 22 patients at the "Centro Oftalmológico Tranjan" who had undergone uncomplicated phacoemulsification and intraocular lens implantation (17 Acrysof ReSTOR NaturalTM, 20 Natural IQ TM performed by the same surgeon, at least three months prior to the study. Patients were subject to frequency doubling technology Matrix Perimeter testing. RESULTS: The patients were between 41 to 79 years old (mean, 70.78 ± 9.83 in the Natural IQ TM and 49 to 81 years old (mean, 67.11± 11.48 in the Acrysof ReSTOR NaturalTM group, and the mean IOP was 13.64 ± 2.02 mmHg in the Natural IQ TM 12.94 ± 1.39 mmHg in the Acrysof ReSTOR NaturalTM group. The mean pupillary diameter under scotopic conditions was 6.63 ± 1.16 mm in the Natural IQ TM group and 7.20 ± 1.8 mm in the Acrysof ReSTOR NaturalTM group (p=0.20. The mean deviation was -1.83 ± 3.46 dB in the Natural IQ TM group and -1.77 ± 3.94 dB in the Acrysof ReSTOR NaturalTM group (p=0.28. The pattern standard deviation was 3.49 ± 0.79 dB in the Natural IQ TM group and 3.20 ± 0.86 dB in the Acrysof ReSTOR NaturalTM group (p=0.27. CONCLUSION: There was no difference in the results of FDT Matrix perimetry in eyes that received apodized diffractive IOLs implant or eyes that received monofocal intraocular lens implant.OBJETIVO: Comparar o efeito da lente difrativa apodizada (Acrysof ReSTOR NaturalTM e da lente de mesma plataforma amarela (Natural IQ TM sobre os resultados da perimetria de dupla frequência (FDT. MÉTODOS: O estudo incluiu 37 olhos de 22 pacientes do Centro Oftalmológico Tranjan que foram submetidos a cirurgia de facoemulsificação e implante de lentes intraoculares (17 Acrysof ReSTOR NaturalTM, 20 Natural IQ TM sem complicações, realizadas pelo mesmo

  7. Beyond the dualism of psyche and soma.

    Science.gov (United States)

    Aisenstein, Marilia

    2008-01-01

    After a historical survey in which the history of the term "psychosomatic" and its invention during the 19th century are retold, as is also the history of modern psychosomatics, the author offers a more personal view, the result of her experience as a classical psychoanalyst and as a practitioner for 27 years at the Paris Institute of Psychosomatics. She develops her current understanding of the theories of the Paris School of Psychosomatics, and selects and elaborates a certain number of concepts essential for clinical work with patients suffering from somatic illnesses. Detailed case studies of two very different patients who are both ill with cancer offer an attempt to show the relevance and application of this specific approach, but which still remains based on psychoanalysis and the most rigorous Freudian metapsychology.

  8. soma vivax in Tselemti woreda , Tigray, Ethiopia

    African Journals Online (AJOL)

    field. Material and Methods. Study Area. The study was carried out at Mekelle Regional Laboratory from November 2002 to April 2003. T. vivax isolate was collected from ... the order of 5-10 trypanosomes per high power microscope field (40X). ..... their studies of the infectivity for mice of Nigerian isolates of T. vivax, that.

  9. INVESTIGATING THE FACTOR STRUCTURE OF THE BLOG ATTITUDE SCALE

    Directory of Open Access Journals (Sweden)

    Zahra SHAHSAVAR

    2010-10-01

    Full Text Available Due to the wide application of advanced technology in education, many attitude scales have been developed to evaluate learners’ attitudes toward educational tools. However, with the rapid development of emerging technologies, using blogs as one of the Web 2.0 tools is still in its infancy and few blog attitude scales have been developed yet. In view of this need, a lot of researchers like to design a new scale based on their conceptual and theoretical framework of their own study rather than using available scales. The present study reports the design and development of a blog attitude scale (BAS. The researchers developed a pool of items to capture the complexity of the blog attitude trait, selected 29 items in the content analysis, and assigned the scale comprising 29 items to 216 undergraduate students to explore the underlying structure of the BAS. In exploratory factor analysis, three factors were discovered: blog anxiety, blog desirability, and blog self-efficacy; 14 items were excluded. The extracted items were subjected to a confirmatory factor analysis which lent further support to the BAS underpinning structure.

  10. Correlación entre la localización del lente intraocular, según biomicroscopia ultrasónica,y diferentes parámetros quirúrgicos en pacientes operados de catarata Correlation between the location of the intraocular lens according to ultrasonic biomicroscopy and several surgical parameters in patients operated from cataract

    Directory of Open Access Journals (Sweden)

    Eneida de la C Pérez Candelaria

    2010-01-01

    Full Text Available OBJETIVO: Determinar la correlación entre la localización del lente intraocular en cámara posterior por biomicroscopia ultrasónica, diferentes parámetros quirúrgicos en pacientes operados de catarata. MÉTODOS: Se realizó un estudio descriptivo, prospectivo y transversal en el Instituto Cubano de Oftalmología «Ramón Pando Ferrer», durante el período de enero a junio del 2007. Se estudiaron variables como: edad, sexo, etiología de la catarata, técnica quirúrgica, localización del lente intraocular según biomicroscopia ultrasónica, así como complicaciones transoperatorias y posoperatorias. RESULTADOS: El 79 % de todos los pacientes operados tenían entre 60 y 79 años de edad y algo más de la mitad correspondió al sexo femenino con un 59 %. La catarata senil fue la etiología que predominó con un 74 % y en el 68 % de los casos el lente se localizó por biomicroscopia ultrasónica en el saco capsular. En los ojos donde el lente intraocular se localizó fuera del saco, la proporción de complicaciones transoperatorias y posoperatorias fueron significativamente mayoritarias, mientras que en los ojos donde el lente intraocular se encontraba en el saco, la mayoría no presentó complicaciones transoperatorias ni posoperatorias. CONCLUSIONES: Las diferencias entre las distintas localizaciones del lente intraocular se encontraron con significación estadística en el tipo de catarata, la presencia de complicaciones transoperatorias y posoperatorias, sin embargo, no se encontró relación estadística significativa entre la localización del lente intraocular con la técnica quirúrgica utilizada.OBJECTIVE: To determine the correlation between the location of the intraocular lens in the posterior chamber using ultrasonic biomicroscopy and the different surgical parameters in patients operated from cataract. METHODS: A prospective, descriptive and cross-sectional study was carried out in "Ramón Pando Ferrer" Cuban Institute of

  11. Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals.

    Science.gov (United States)

    Bulgari, Dinara; Zhou, Chaoming; Hewes, Randall S; Deitcher, David L; Levitan, Edwin S

    2014-03-04

    Neurons vary in their capacity to produce, store, and release neuropeptides packaged in dense-core vesicles (DCVs). Specifically, neurons used for cotransmission have terminals that contain few DCVs and many small synaptic vesicles, whereas neuroendocrine neuron terminals contain many DCVs. Although the mechanistic basis for presynaptic variation is unknown, past research demonstrated transcriptional control of neuropeptide synthesis suggesting that supply from the soma limits presynaptic neuropeptide accumulation. Here neuropeptide release is shown to scale with presynaptic neuropeptide stores in identified Drosophila cotransmitting and neuroendocrine terminals. However, the dramatic difference in DCV number in these terminals occurs with similar anterograde axonal transport and DCV half-lives. Thus, differences in presynaptic neuropeptide stores are not explained by DCV delivery from the soma or turnover. Instead, greater neuropeptide accumulation in neuroendocrine terminals is promoted by dramatically more efficient presynaptic DCV capture. Greater capture comes with tradeoffs, however, as fewer uncaptured DCVs are available to populate distal boutons and replenish neuropeptide stores following release. Finally, expression of the Dimmed transcription factor in cotransmitting neurons increases presynaptic DCV capture. Therefore, DCV capture in the terminal is genetically controlled and determines neuron-specific variation in peptidergic function.

  12. Nueva variante de abordaje al surco ciliar en la fijación transescleral de lentes de cámara posterior New variant of approach to the ciliary sulcus in the transcleral fixation of posterior chamber lens

    Directory of Open Access Journals (Sweden)

    Ileana Vila Dópico

    2002-06-01

    Full Text Available Se expone una variante de abordaje al surco ciliar para la fijación del lente intraocular de cámara posterior, que está a nuestro alcance, en pacientes en que no existe soporte capsular o este es insuficiente. Se describe la técnica. Se realizó en 17 pacientes de los que se obtuvo mejoría visual en todos los casos (20/50-20/20 con un seguimiento promedio de 12 meses. Esta variante tiene la ventaja de evitar el paso de la aguja por el surco ciliar a ciegas, pues se utiliza el abordaje a través de la esclera y con ello evitamos dañar estructuras oculares aledañas evitando el riesgo de complicaciones por lo que se logra la recuperación anatómica y funcional en todos los casos.A variant to approach the ciliary sulcus for fixating the posterior chamber intraocular lens, which is within our reach, in patients with insufficient or no capsular support, is explained. The technique is described here and it was applied to 17 patients. Visual improvement was obtained in all cases (20/50-20/20 with an average follow-up of 12 months. This variant allows to prevent the blind passage of the needle through the ciliary sulcus, since it is approached via the sclera, avoiding to damage adjoining ocular structures and to have complications, and making possible the anatomic and functional recovery of all patients.

  13. Efectividad de la lente intraocular ACRI. SMART 46-S en la cirugía de catarata por microincisiones Effectiveness of the intraocular lens ACRI SMART 46-S in micro-incision cataract surgery

    Directory of Open Access Journals (Sweden)

    Juan Raúl Hernández Silva

    2007-12-01

    Full Text Available El perfeccionamiento y aplicación de una industria destinada a modernizar las lentes intraoculares y el instrumental quirúrgico ha impulsado un conjunto de adelantos que han permitido optimizar, corregir y refinar las técnicas quirúrgicas para la cirugía de la catarata y en especial la facoemulsificación. El punto más importante en esta cadena de adelantos está enmarcado y encaminado a disminuir el tamaño de la incisión quirúrgica que permita solucionar un número importante de complicaciones que con relativa frecuencia se presentan con la aplicación de las técnicas quirúrgicas convencionales extracapsular e intracapsular con incisiones mayores a los 10 mm. Actualmente se han desarrollado técnicas quirúrgicas conocidas como cirugía de la catarata por microincisiones .Se realizó un estudio descriptivo y retrospectivo, cuyo universo estuvo constituido por 27 pacientes (ojos con diagnóstico de catarata presenil y senil, que recibieron tratamiento quirúrgico con la técnica de facoemulsificación por microinsiciones e implante de lente intraocular de cámara posterior de una pieza, plegable de acrílico, de un tamaño de 11 x 6 mm de óptica, modelo Acri. Smart 46 S con inyector, en el Centro de Microcirugía Ocular del Instituto Cubano de Oftalmología “Ramón Pando Ferrer”, en el período comprendido desde enero 2004 hasta enero 2005. Se encontró que la mayoría de los casos tenían más de 50 años, se alcanzó una recuperación significativa de la mejor agudeza visual corregida en el posoperatorio, el astigmatismo inducido fue bajo. En cuanto a los parámetros facodinámicos utilizados, el poder de ultrasonido fue como promedio bajo. Las complicaciones presentadas fueron pocas, salida de vítreo secundaria a rotura de la cápsula posterior ocurrió más frecuentemente. Se concluye que la técnica quirúrgica MICS con implante de lente Acri.Smart 46 S constituye una opción válida, segura y eficaz en el tratamiento de la

  14. The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University

    Energy Technology Data Exchange (ETDEWEB)

    Tharavichtikul, Ekkasit; Chitapanarux, Taned; Chakrabandhu, Somvilai; Klunklin, Pitchayaponne; Onchan, Wimrak; Wanwilairat, Somsak; Chitapanarux, Imjai [Faculty of Medicine, Chiang Mai University, Chiang Mai (Thailand); Meungwong, Pooriwat [Lampang Cancer Hospital, Lampang (Thailand); Traisathit, Patrinee [Faculty of Science, Chiang Mai University, Chiang Mai (Thailand); Galalae, Razvan [aculty of Medicine, Christian-Albrechts University at Kiel, Kiei (Germany)

    2014-06-15

    To evaluate association between equivalent dose in 2 Gy (EQD2) to rectal point dose and gastrointestinal toxicity from whole pelvic radiotherapy (WPRT) and intracavitary brachytherapy (ICBT) in cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University. Retrospective study was designed for the patients with locally advanced cervical cancer, treated by radical radiotherapy from 2004 to 2009 and were evaluated by rectosigmoidoscopy. The cumulative doses of WPRT and ICBT to the maximally rectal point were calculated to the EQD2 and evaluated the association of toxicities. Thirty-nine patients were evaluated for late rectal toxicity. The mean cumulative dose in term of EQD2 to rectum was 64.2 Gy. Grade 1 toxicities were the most common findings. According to endoscopic exam, the most common toxicities were congested mucosa (36 patients) and telangiectasia (32 patients). In evaluation between rectal dose in EQD2 and toxicities, no association of cumulative rectal dose to rectal toxicity, except the association of cumulative rectal dose in EQD2 >65 Gy to late effects of normal tissue (LENT-SOMA) scale > or = grade 2 (p = 0.022; odds ratio, 5.312; 95% confidence interval, 1.269-22.244). The cumulative rectal dose in EQD2 >65 Gy have association with > or = grade 2 LENT-SOMA scale.

  15. The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University.

    Science.gov (United States)

    Tharavichtikul, Ekkasit; Meungwong, Pooriwat; Chitapanarux, Taned; Chakrabandhu, Somvilai; Klunklin, Pitchayaponne; Onchan, Wimrak; Wanwilairat, Somsak; Traisathit, Patrinee; Galalae, Razvan; Chitapanarux, Imjai

    2014-06-01

    To evaluate association between equivalent dose in 2 Gy (EQD2) to rectal point dose and gastrointestinal toxicity from whole pelvic radiotherapy (WPRT) and intracavitary brachytherapy (ICBT) in cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University. Retrospective study was designed for the patients with locally advanced cervical cancer, treated by radical radiotherapy from 2004 to 2009 and were evaluated by rectosigmoidoscopy. The cumulative doses of WPRT and ICBT to the maximally rectal point were calculated to the EQD2 and evaluated the association of toxicities. Thirty-nine patients were evaluated for late rectal toxicity. The mean cumulative dose in term of EQD2 to rectum was 64.2 Gy. Grade 1 toxicities were the most common findings. According to endoscopic exam, the most common toxicities were congested mucosa (36 patients) and telangiectasia (32 patients). In evaluation between rectal dose in EQD2 and toxicities, no association of cumulative rectal dose to rectal toxicity, except the association of cumulative rectal dose in EQD2 >65 Gy to late effects of normal tissue (LENT-SOMA) scale ≥ grade 2 (p = 0.022; odds ratio, 5.312; 95% confidence interval, 1.269-22.244). The cumulative rectal dose in EQD2 >65 Gy have association with ≥ grade 2 LENT-SOMA scale.

  16. Comportamento e características de usuários de lentes de contato entre estudantes universitários da área de saúde The behavior and characteristics of contact lens wearers among university students in health related areas

    Directory of Open Access Journals (Sweden)

    Cleusa Coral Ghanem

    2000-04-01

    Full Text Available Objetivo: Estudar o comportamento e características de usuários de lentes de contato ligados à área de saúde. Método: Realizou-se um levantamento entre universitários da área de saúde da Pontifícia Universidade Católica do Paraná, em Curitiba, no período de 23 a 27 de novembro de 1998. Para a coleta de dados foi utilizado um questionário auto-aplicável, previamente testado. Resultados e Discussão: Dentre 1.173 estudantes, 207 (17,2% usavam lentes de contato, sendo 78,3% do sexo feminino e 21,7% do sexo masculino. Eram usuários de lentes rígidas 12,1% e 87,9% utilizavam hidrofílicas, demonstrando um aumento progressivo das últimas quando se compara a estudos nacionais anteriores. Dos usuários de lentes de contato hidrofílicas, 57,6% utilizavam descartáveis e desses 88,5% não as utilizavam de acordo com os padrões de uso e descartabilidade estabelecidos. Do número total de usuários, 37,7% relataram algum problema ocular durante o uso. Embora 97,1% tenham feito a adaptação com o oftalmologista, 14,2% dos usuários de descartáveis não obtiveram novas lentes em clínicas oftalmológicas. Por outro lado, 81,1% procuraram o oftalmologista, semestral ou anualmente, para a revisão da adaptação. Recomendação: Para reduzir o número de complicações e a desistência do uso de lentes de contato, o usuário deve ser educado sobre a forma correta de utilizá-las, ser orientado sobre os sinais e sintomas de alerta para problemas oculares e receber as informações também por escrito.Purpose: To study the behavior and characteristics of contact lens wearers involved in health areas. Methods: To conduct a survey among students of health related courses at the Pontifícia Universidade Católica do Paraná, in Curitiba, during the period from 23rd to 27th November 1998. A previously tested, self-applicable questionnaire was used to collect data. Results and Discussion: Among 1,173 students, 207 (17.2% used contact lenses, of

  17. Incidência de opacificação de cápsula posterior em pacientes submetidos à facoemulsificação e implante de lentes intra-oculares acrílicas hidrofílicas expansíveis Incidence of posterior capsule opacification in patients submitted to phacoemulsification and expandable acrylic intraocular lens implantation

    Directory of Open Access Journals (Sweden)

    Hilton Arcoverde Gonçalves de Medeiros

    2006-06-01

    Full Text Available OBJETIVO: Avaliar prospectivamente os resultados das lentes intra-oculares de polímeros expansíveis implantadas em pacientes submetidos à facoemulsificação, quanto à incidência de opacificação de cápsula posterior, levando em consideração a biocompatibilidade das lentes expansíveis. MÉTODOS: O grupo de estudo foi composto por 830 pacientes, 1.200 olhos, que foram submetidos a facoemulsificação, utilizando a mesma técnica, variando-se apenas o diâmetro da capsulorrexe, pelo mesmo cirurgião, no período de 1998 a 2002, com implante de lente intra-ocular hidrofílica expansível. O acompanhamento médio foi de 2,4 anos, variando de seis meses a quatro anos. RESULTADOS: O número total de opacificação de cápsula posterior foi de 54 casos. CONCLUSÃO: A incidência de opacificação de cápsula posterior encontrada no grupo foi de 4,6%.PURPOSE: To evaluate prospectively the results of expandable acrylic intraocular lenses in patients submitted to phacoemulsification as regard posterior capsule opacification. METHODS: The study group consisted of 830 patients, 1,200 eyes that underwent phacoemulsification from 1998 to 2002, by the same surgeon, using the same technique but with different diameters of capsulorrhexis, with expandable hydrophilic acrylic intraocular lens implantation. The mean follow-up was 2.4 years, ranging from 6 months to 4 years. RESULTS: The total number of posterior capsule opacification was 54 cases. CONCLUSIONS: The incidence of posterior capsule opacification was 4.6% in these patients.

  18. Reacción inmunológica a la lente de contacto terapéutico después de cirugía refractiva: Presentación de un caso Immunological reaction to therapeutical contact lens after the refractive surgery: A case presentation

    Directory of Open Access Journals (Sweden)

    Raúl Pérez Suárez

    2007-06-01

    Full Text Available Se presenta un caso de reacción inmunológica a lente de contacto blanda terapéutica después de cirugía refractiva (Epi-Lasik, que presentó infiltrados corneales. Se realizó estudio de las lesiones, seguimiento clínico y se evaluó la respuesta al tratamiento. Los infiltrados desaparecieron rápidamente al retirar la lente de contacto e instaurar tratamiento con esteroides tópicos. El diagnóstico exacto y el manejo apropiado de los infiltrados corneales en pacientes que usan lentes de contacto es de gran importancia por la posibilidad de infección o de secuela visual permanente. La microscopia confocal es un estudio de gran ayuda para el diagnóstico porque permite observar las células inflamadas y la profundidad del proceso inflamatorioA case of immunological reaction to therapeutical soft contact lens after refractive surgery (Epi-Lasik, with corneal infiltrates, was presented. The lesiones were studied; the patient was clinically followed-up with the subsequent evaluation of response to treatment. The infiltrates quickly disappeared when the contact lens was removed and topical steroids-based treatment was applied. The accurate diagnosis and the adequate management of corneal infiltrates in patients wearing contact lenses is of great importance because of possible infections and permanent visual sequelae. Confocal microscopy is a very helpful study for diagnosis since it allows observing inflammatory cells and deep inflammatory process

  19. Implante intra-ocular de lentes dobráveis "piggyback" em paciente portador de catarata congênita no primeiro ano de vida: relato de caso Piggyback foldable intraocular lens implant in patient with congenital cataract in the first year of life: case report

    Directory of Open Access Journals (Sweden)

    Leonardo Akaishi

    2004-12-01

    Full Text Available No presente relato os autores descrevem um caso de catarata congênita unilateral tratada cirurgicamente com implante intra-ocular de lentes dobráveis "piggyback", ainda não descrito na literatura nacional. São analisadas as diferenças e semelhanças com outros casos descritos na literatura.The authors report a case of congenital cataract, which was treated with piggyback foldable intraocular lens implant, not described in the Brazilian literature. The differences and similarities are analyzed with other reported cases in the literature.

  20. Empleo de filtros en lentes de contacto

    OpenAIRE

    López de Dueñas, María

    2016-01-01

    Gracias al ozono de la estratosfera y a los tejidos oculares a la retina sólo llegan, la luz visible y una pequeña parte de UVA, e IRA. Cuando la radiación entra en un tejido vivo destruye o modifica enlaces provocando anormalidades celulares. Aunque el ojo solo absorbe una pequeña cantidad de radiación el daño que causa depende del tiempo de exposición. Por esto se usan filtros ópticos, dispositivos que disminuyen el paso de un determinado intervalo de longitudes de onda. Estos filtros se añ...

  1. Festina Lente. Pospíchej pomalu

    Czech Academy of Sciences Publication Activity Database

    Hanika, Jiří

    2008-01-01

    Roč. 102, č. 11 (2008), s. 955-956 ISSN 0009-2770 Institutional research plan: CEZ:AV0Z40720504 Keywords : fuel consumption * carbon dioxide production * environment Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 0.593, year: 2008

  2. Qualidade de vida de pacientes pseudofácicos submetidos à cirurgia de catarata com implante de lente intra-ocular acomodativa Quality of life of pseudophakic patients with accommodative intraocular lens implant

    Directory of Open Access Journals (Sweden)

    Filipe de Oliveira

    2004-06-01

    Full Text Available OBJETIVO: Avaliar a função visual e satisfação dos pacientes submetidos à cirurgia de catarata com implante de lente intra-ocular acomodativa e o impacto na sua qualidade de vida. MÉTODOS: Retrospectivamente, foram avaliados questionários aplicados após um ano da cirurgia de 22 pacientes que foram incluídos num estudo clínico para avaliar segurança e eficácia de uma lente intra-ocular de silicone de câmara posterior designada para corrigir visão para longe e perto. RESULTADOS: Do total dos pacientes operados, 16 (73% eram bilaterais e 6 (27% unilaterais, com idade média de 70,2 anos. Dos pacientes com implante unilateral, 5 (83,3% declararam melhora acentuada da visão e 1 (16,7% referiu máxima melhora. Quanto ao nível de satisfação, 5 (83,3% ficaram satisfeitos e 1 (16,7% muito satisfeito com o resultado cirúrgico. A visão noturna foi declarada como sem dificuldade por 3 (50,0%, pouca dificuldade por 2 (33,3% e dificuldade moderada por 1 (16,7%. No grupo bilateral, 7 (43,8% consideraram excelente a qualidade da visão para perto, 7 (43,8% muito boa, 1 (6,2% adequada e 1 (6,2% ruim. A visão intermediária foi classificada como excelente por 6 (37,5%, muito boa por 9 (56,3% e adequada por 1 (6,2%. A qualidade da visão para longe foi considerada excelente por 9 (56,3%, muito boa por 3 (43,8%, adequada por 2 (12,5% e não muito boa por 2 (12,5%. Em relação à visão noturna 9 (56,3% declararam não ter dificuldade alguma, 5 (31,2% pouca dificuldade e 2 (12,5% dificuldade moderada. CONCLUSÕES: Considerando a propriedade óptica da LIO, a maioria dos pacientes apresentou uma melhora considerável da função visual, sem a necessidade de correção óptica, e, portanto, com impacto positivo na qualidade de vida.PURPOSE: To evaluate the visual function and satisfaction of patients who underwent cataract surgery and were implanted with an accommodative intraocular lens and the impact in their quality of life. METHODS

  3. Measurement of the anti reactivity of a control rod of G1, by a slow oscillation method; Mesure de l'antireactivite d'une barre de reglage de G1 pour une methode d'oscillation lente

    Energy Technology Data Exchange (ETDEWEB)

    Breton, D; Leroy, J; Vidal, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1957-07-01

    It is possible to determine the effect of the end of a control rod on the reactivity of the pile by measuring the modulation induced in the neutron flux by the slow oscillation of this control rod. The total effect of the control rod can be deduced, given certain hypothesis and corrections, from the experimental curve giving the effect of the end of the rod as a function of its position. This method has the advantage of permitting the measurement of very large anti reactivities, such as p= 10{sup -2} for example, which would not be possible by other kinetic methods. Thus the control rod B{sub 3}, in the low position, brings about a reduction in reactivity equal to 1130 p.c.m. {+-} 30 in the pile charged with 518 fuel elements, on one side only of the slit. We have compared the oscillation method with the classical divergence method, in the fields where the two measurements were possible: a satisfactory agreement was found. We have established that the phase displacement between the oscillation of the rod and the modulation of the flux varied greatly with the position of the rod. This variation cannot be explained on the basis of the dynamic model independent of space; we have attributed it to the influence of spatial harmonics of the flux distribution, and have determined a correction which frees the measurements of this influence. (author) [French] II est possible de determiner l'effet de l'extremite d'une barre de reglage sur la reactivite de la pile, a partir de la mesure de la modulation induite dans le flux neutronique par l'oscillation lente de cette barre de reglage. L'effet total de la barre de reglage peut etre deduit, moyennant certaines hypotheses et certaines corrections, de la courbe experimentale donnant l'effet de l'extremite de la barre en fonction de sa position. Cette methode a l'avantage de rendre possible la mesure d'antireactivites tres grandes, telles que p = 10{sup -2} par exemple, ce qui ne serait pas possible par d'autres methodes

  4. Comparação da análise da frente de onda e da sensibilidade ao contraste em olhos pseudofácicos com implante de lentes intra-oculares esférica e asférica Wavefront analysis and contrast sensitivity comparison between spheric and aspheric intraocular lenses

    Directory of Open Access Journals (Sweden)

    Wilson Takashi Hida

    2008-06-01

    Full Text Available OBJETIVO: Comparar a análise da frente de onda e a sensibilidade de contraste pós-operatórias em pacientes submetidos à facoemulsificação com implante de lentes intra-oculares esféricas num olho e asféricas no olho contralateral. MÉTODOS: Este estudo prospectivo comparativo, randomizado, duplo-cego, incluiu 32 olhos de 16 pacientes. Uma avaliação oftalmológica completa foi realizada durante as visitas antes e depois da cirurgia (no primeiro, terceiro, sétimo, e nonagésimo dias pós-cirúrgicos, que incluiu acuidade visual, teste de sensibilidade ao contraste, aberrometria. Todos exames (menos aberrometr=ia foram feitos monocularmente com pupilas não dilatadas. Os pacientes foram submetidos a facectomia ultra-sônica convencional com implante de uma lente asférica SN60WF num olho e esférica SN60ATno outro. RESULTADOS: A acuidade visual média com a melhor correção foi -0,146 LogMAR no grupo da lente intra-ocular esférica, e -0.165 logMAR no grupo da lente intra-ocular asférica sob condições fotópicas, -0,003 LogMAR sob condições mesópicas. A sensibilidade ao contraste foi semelhante em ambos os grupos tanto em condições fotópicas e mesópicas. Em relação às aberrações ópticas ocorreu uma diferença significativa nas aberrações totais (1,09 ± 0,56 no grupo asférico e 1,52 ± 1,19 no grupo esférico e no componente esférico das aberrações de alta ordem(0,422 ± 0,202 no grupo asférico e 0,124 ± 0,087 no grupo esférico. CONCLUSÃO: As duas lentes intra-oculares promoveram uma excelente visão em situações de alto contraste, e os olhos implantados com a lente asférica tiveram menos aberrações totais e esféricas que aqueles implantados com a lente esférica.PURPOSE: Compare the wavefront and contrast sensitivity of bilateral pseudophakic patients with aspheric in one eye and spheric intraocular lenses in the other. METHODS: This prospective, comparative, randomized study, double masked, included 32

  5. Scale Pretesting

    Science.gov (United States)

    Howard, Matt C.

    2018-01-01

    Scale pretests analyze the suitability of individual scale items for further analysis, whether through judging their face validity, wording concerns, and/or other aspects. The current article reviews scale pretests, separated by qualitative and quantitative methods, in order to identify the differences, similarities, and even existence of the…

  6. Avaliação do edema macular após cirurgia não complicada de facoemulsificação com implante de lente intraocular por meio da tomografia de coerência óptica spectral domain

    Directory of Open Access Journals (Sweden)

    Everton Paroschi Corrêa

    2013-12-01

    Full Text Available OBJETIVO: Avaliar o edema macular após cirurgia não complicada de facoemulsificação com implante de lente intraocular por meio da tomografia de coerência óptica spectral domain (OCT-SD. MÉTODOS: Foi realizado estudo prospectivo em 62 olhos de pacientes submetidos à facoemulsificação com implante de lente intraocular. Os pacientes foram avaliados antes e após a cirurgia, no primeiro dia, e na primeira, segunda e quarta semanas. Acuidade visual (AV, células na câmara anterior e tomografia de coerência óptica macular cubo 200x200 foram medidos. RESULTADOS: Após a cirurgia de facoemulsificação houve melhora da acuidade visual, inflamação decrescente, e a espessura e o volume macular aumentaram. Ocorreu um caso de edema macular cistoide. Houve correlação inversa fraca entre a acuidade visual e a espessura macular central, e entre a acuidade visual e o volume macular. Foi observada correlação direta fraca entre a inflamação e o volume macular. CONCLUSÃO: Edema macular subclínico desenvolve-se mesmo após cirurgia de catarata não complicada em pacientes não predispostos. A tomografia de coerência óptica spectral domain foi capaz de detectar pequenos aumentos na espessura macular no período avaliado.

  7. Análise da fórmula SRK/T no cálculo de lente intra-ocular em cães portadores de catarata Analysis of the SRK/T formula for calculation of intra-ocular lens in dogs carrying cataract

    Directory of Open Access Journals (Sweden)

    T.P. Peixoto

    2008-12-01

    Full Text Available Foram utilizados 20 cães de raças e idades variadas, machos e fêmeas, portadores de catarata e não diabéticos, os quais foram submetidos ao exame oftálmico. Posteriormente, realizaram-se mensurações oculares empregando-se um ecobiômetro ultra-sônico (ultra-sonografia modo-A para o cálculo do poder dióptrico da lente intra-ocular por meio da fórmula SRK/T. O comprimento axial médio foi de 19,94±1,12mm. Todos os animais foram submetidos à facoemulsificação extracapsular. A lente calculada foi implantada no transoperatório da cirurgia de catarata, obtendo-se média de 37,33±3,05D. A avaliação pós-cirúrgica do erro refracional aos 60 dias de pós-operatório, pela retinoscopia, com a utilização da esquiascopia, foi de 5,57±1,59D. A fórmula SRK/T não ofereceu bons resultados.Twenty males and females non-diabetic dogs of different breeds and ages underwent ophthalmic examination because they presented catarats. Ocular measurements were performed by echobiometry (A-scan ultrasound for intraocular lens power calculation using the SRK/T formula. The obtained mean axial length was 19.94±1.12mm. All animals were submitted to extracapsular phacoemulsification; the mean intraocular lens power implanted was 37.33±3.05. At 60 days postoperative, the refractional error assessed via retinoscopy was 5.57±1.59 D. The SRK/T formula did not offer good results.

  8. Modelagem e Simulação da Polimerização Termo e Foto-Iniciada de Resinas Di-Carbonato Di-Alila do Etileno Glicol para a Produção de Lentes Oftálmicas

    Directory of Open Access Journals (Sweden)

    Brogna Fábio M. S.

    2002-01-01

    Full Text Available O polímero termofixo conhecido comercialmente como CR-39 é amplamente utilizado em aplicações ópticas. No processo convencional, utilizam-se peróxidos orgânicos como termo-iniciadores da polimerização. Devido à natureza altamente exotérmica da reação de polimerização, esse processo deve ser conduzido em baixas temperaturas e ocorre lentamente para se evitar defeitos, especialmente no caso de se produzir lentes mais espessas. A utilização de foto-iniciação com ultravioleta, por exemplo, permite uma polimerização mais rápida e reduz os efeitos exotérmicos da reação; por outro lado, a alta taxa de reação e a rápida liberação de calor podem causar defeitos nas lentes. O conhecimento dos perfis de temperatura e de conversão dentro do material durante a polimerização é essencial para se otimizar os processos, tanto termo quanto foto-iniciado. Neste trabalho são estudados modelos para simular esses processos. Os balanços de massa e de energia resultam em equações diferenciais parciais que são resolvidas através do método da Colocação Ortogonal e do método de Runge-Kutta-Gill.

  9. Maslowian Scale.

    Science.gov (United States)

    Falk, C.; And Others

    The development of the Maslowian Scale, a method of revealing a picture of one's needs and concerns based on Abraham Maslow's levels of self-actualization, is described. This paper also explains how the scale is supported by the theories of L. Kohlberg, C. Rogers, and T. Rusk. After a literature search, a list of statements was generated…

  10. Framing scales and scaling frames

    NARCIS (Netherlands)

    van Lieshout, M.; Dewulf, A.; Aarts, N.; Termeer, K.

    2009-01-01

    Policy problems are not just out there. Actors highlight different aspects of a situation as problematic and situate the problem on different scales. In this study we will analyse the way actors apply scales in their talk (or texts) to frame the complex decision-making process of the establishment

  11. Initial Scale Development of the Contextual Support for Post-Secondary Planning Scales

    Science.gov (United States)

    Ali, Saba Rasheed; Martens, Jessica Kelly; Button, Christopher; Larma, Nicholas C.

    2011-01-01

    Vocational psychologists and career theorists have articulated the importance of social support in the development of career plans for high school youth. More recently, Lent, Brown, and Hackett carefully articulated the location of contextual supports in the Social Cognitive Career Theory (SCCT) framework. However, there is a paucity of research…

  12. Comparação entre os resultados pós-operatórios de pacientes submetidos ao procedimento tríplice e transplante de córnea combinado a fixação secundária de lente intra-ocular Comparison between the postoperative results of triple procedure and combined penetrating keratoplasty/ transsclerally sutured posterior chamber lens implantation

    Directory of Open Access Journals (Sweden)

    Daniela Maggioni Pereira Leão

    2006-08-01

    Full Text Available OBJETIVO: Comparar os resultados pós-operatórios de 2 grupos de pacientes submetidos a transplante de córnea com técnicas e tempo cirúrgico diferentes, em relação à abordagem do cristalino e/ou lente intra-ocular. MÉTODOS: Neste estudo retrospectivo foram analisados 37 olhos de pacientes divididos em 2 grupos: extração de catarata, implante de lentes intra-oculares (LIO e transplante de córnea no mesmo tempo cirúrgico - grupo 1 (G1 e extração de catarata sem implante de lentes intra-oculares no primeiro tempo cirúrgico e fixação secundária de lentes intra-oculares associada a transplante de córnea no segundo tempo cirúrgico - grupo 2 (G2. As variáveis estudadas foram: acuidade visual, pressão intra-ocular (PIO, astigmatismo refracional, astigmatismo ceratométrico e complicações pós-operatórias. RESULTADOS: Foi observado melhora da acuidade visual nos 2 grupos (G1 pPURPOSE: To compare the outcomes of two surgical techniques of penetrating keratoplasty with different surgical time, regarding the crystalline and the intraocular lens. METHODS: This retrospective study included 37 patients' eyes divided into 2 groups: extracapsular cataract extraction, posterior chamber intraocular lens implantation and penetrating keratoplasty (Group 1, G1 and transscleral fixation of posterior chamber lens and penetrating keratoplasty (Group 2, G2. The following parameters were recorded: visual acuity, intraocular pressure, refractive astigmatism, complication and keratometric astigmatism. RESULTS: Visual acuity improved in the two groups (G1 p<0.001 and G2 p=0.008. In G2 a significant change for the worse of intraocular pressure outcome was observed when compared with the other group (p=0.014. Regarding refractive and keratometric astigmatism no significant differences between the groups were found. The follow-up was 11 months. CONCLUSION: The most important negative prognostic factor affecting visual acuity was the postkeratoplasty

  13. Scaling down

    Directory of Open Access Journals (Sweden)

    Ronald L Breiger

    2015-11-01

    Full Text Available While “scaling up” is a lively topic in network science and Big Data analysis today, my purpose in this essay is to articulate an alternative problem, that of “scaling down,” which I believe will also require increased attention in coming years. “Scaling down” is the problem of how macro-level features of Big Data affect, shape, and evoke lower-level features and processes. I identify four aspects of this problem: the extent to which findings from studies of Facebook and other Big-Data platforms apply to human behavior at the scale of church suppers and department politics where we spend much of our lives; the extent to which the mathematics of scaling might be consistent with behavioral principles, moving beyond a “universal” theory of networks to the study of variation within and between networks; and how a large social field, including its history and culture, shapes the typical representations, interactions, and strategies at local levels in a text or social network.

  14. Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis

    International Nuclear Information System (INIS)

    Oliai, Caspian; Fisher, Brandon; Jani, Ashish; Wong, Michael; Poli, Jaganmohan; Brady, Luther W.; Komarnicky, Lydia T.

    2012-01-01

    Purpose: To provide a retrospective analysis of the efficacy of hyperbaric oxygen therapy (HBOT) for treating hemorrhagic cystitis (HC) and proctitis secondary to pelvic- and prostate-only radiotherapy. Methods and Materials: Nineteen patients were treated with HBOT for radiation-induced HC and proctitis. The median age at treatment was 66 years (range, 15–84 years). The range of external-beam radiation delivered was 50.0–75.6 Gy. Bleeding must have been refractory to other therapies. Patients received 100% oxygen at 2.0 atmospheres absolute pressure for 90–120 min per treatment in a monoplace chamber. Symptoms were retrospectively scored according to the Late Effects of Normal Tissues—Subjective, Objective, Management, Analytic (LENT-SOMA) scale to evaluate short-term efficacy. Recurrence of hematuria/hematochezia was used to assess long-term efficacy. Results: Four of the 19 patients were lost to follow-up. Fifteen patients were evaluated and received a mean of 29.8 dives: 11 developed HC and 4 proctitis. All patients experienced a reduction in their LENT-SOMA score. After completion of HBOT, the mean LENT-SOMA score was reduced from 0.78 to 0.20 in patients with HC and from 0.66 to 0.26 in patients with proctitis. Median follow-up was 39 months (range, 7–70 months). No cases of hematuria were refractory to HBOT. Complete resolution of hematuria was seen in 81% (n = 9) and partial response in 18% (n = 2). Recurrence of hematuria occurred in 36% (n = 4) after a median of 10 months. Complete resolution of hematochezia was seen in 50% (n = 2), partial response in 25% (n = 1), and refractory bleeding in 25% (n = 1). Conclusions: Hyperbaric oxygen therapy is appropriate for radiation-induced HC once less time-consuming therapies have failed to resolve the bleeding. In these conditions, HBOT is efficacious in the short and long term, with minimal side effects.

  15. KNO scaling

    International Nuclear Information System (INIS)

    Golokhvastov, A.I.; )

    2001-01-01

    A correct version of the KNO scaling of multiplicity distributions is discussed in detail. Some assertions on KNO-scaling violation based on the misinterpretation of experimental data behavior are analyzed. An accurate comparison with experiment is presented for the distributions of negative particles in e + e - annihilation at √S = 3 - 161 GeV, in inelastic pp interactions at √S = 2.4 - 62 GeV and in nucleus-nucleus interactions at p lab = 4.5 - 520 GeV/c per nucleon. The p-bar p data at √S 546 GeV are considered [ru

  16. Refractive error changes in children with intermittent exotropia under overminus lens therapy Alterações nos vícios refracionais em crianças com exotropia intermitente submetidas ao tratamento por meio da hipercorreção com lentes negativas

    Directory of Open Access Journals (Sweden)

    Jayter Silva de Paula

    2009-12-01

    Full Text Available PURPOSE: Intermittent exotropia may be decreased by stimulation of accommodative convergence. Once excessive accommodation has been related to myopia, our objective was to evaluate refractive errors changes in children under overcorrecting minus lens therapy. METHODS: A retrospective chart review of 21 children with intermittent exotropia was performed. All patients were treated with occlusion, and a 13-patient subset of them received overminus lens therapy (group A. Eight children received spectacles as necessary (group B. Initial age, age interval, initial spherical equivalent (SE, and magnitude of overcorrection were considered as co-variables of the mean variation in refractive error (SE of each eye between groups, through a multivariate analysis. RESULTS: Overcorrection used in group A ranged from 0.5 D to 3.5 D (2.46 ± 0.87 D. Although initial SE of each eye was significant different between group A and B (OD - p=0.02; OS - p=0.01, initial age (p=0.69, age interval (p=0.90, and mean variation in refractive errors (p=0.36 did not differ between groups. Multivariate analysis with linear regression showed no significantly difference regarding all co-variables enrolled. CONCLUSIONS: Treatment of intermittent exotropia with overcorrecting minus lens did not induce refractive errors changes, even considering age, treatment period, initial spherical equivalent and overcorrection magnitude used.OBJETIVO: A exotropia intermitente pode ser diminuída pela estimulação da convergência acomodativa. Uma vez que uma acomodação excessiva tem sido relacionada à miopização, o objetivo deste trabalho foi o de avaliar alterações nos vícios de refração de crianças submetidas à hipercorreção com lentes negativas. MÉTODOS: Foi realizada revisão dos prontuários de 21 crianças com exotropia intermitente. Todos os pacientes foram tratados com oclusão, sendo que 13 deles foram submetidos à hipercorreção com lentes negativas (grupo A. As 8

  17. Estudo prospectivo comparativo de duas técnicas cirúrgicas de extração extra-capsular planejada de catarata com implante de lente intra-ocular: incisão limbar e incisão escleral tunelizada Prospective comparative study of two techniques of planned extracapsular cataract extraction: limbal incision and scleral tunnel incision

    Directory of Open Access Journals (Sweden)

    Lincoln Lemes Freitas

    2001-06-01

    Full Text Available Introdução: A catarata é responsável por 50% da cegueira no mundo, com um número estimado de 15 milhões de casos que necessitariam cirurgia. Diferentes técnicas para a extração extra-capsular da catarata com implante de lente intra-ocular foram propostas. Objetivo: Comparar as técnicas para extração extra-capsular de catarata com implante de lente intra-ocular utilizando incisão limbar e incisão escleral tunelizada. Métodos: Foram avaliados, prospectivamente, 59 olhos de 54 pacientes com acompanhamento pós-operatório de 6 meses. Aleatoriamente, os pacientes foram divididos em dois grupos. No Grupo I (n=30, a técnica realizada foi a de extração extra-capsular com implante de lente intra-ocular com incisão limbar e no Grupo II (n=29, com incisão tunelizada. Foram avaliadas as medidas da acuidade visual corrigida, inflamação intra-ocular (células e "flare", tempo de cirurgia, microscopia especular, astigmatismo ceratométrico induzido e paquimetria. Resultados: O tempo de cirurgia, a perda de células endoteliais e o astigmatismo ceratométrico induzido foram estatisticamente maiores no Grupo I que no Grupo II. Não houve diferença estatisticamente significante entre os grupos I e II quanto à acuidade visual, a quantidade de células na câmara anterior, a quantidade de "flare" na câmara anterior e paquimetria. Conclusão: A técnica para extração extra-capsular de catarata com incisão tunelizada apresentou vantagens quanto ao tempo de cirurgia, perda de células endoteliais e astigmatismo induzido em relação à técnica com incisão limbar. Os passos utilizados nessa técnica visam facilitar a extração da catarata, além de treinar o cirurgião para uma transição mais segura para facoemulsificação, sem aumentar o custo da cirurgia.Purpose: Cataract is the main cause of blindness throughout the world, affecting more than 15 million people worldwide. There are different techniques for extracapsular cataract

  18. Late sequelae and cosmetic outcome after radiotherapy in breast conserving therapy

    International Nuclear Information System (INIS)

    Dore, M.; Hennequin, C.

    2012-01-01

    Radiotherapy after breast-conserving therapy for early breast cancer is reported to adversely affect the cosmetic outcome. The incidence of radiation-induced fibro-atrophy is around 10% at 5 years. A better knowledge of its pathophysiology has revealed the essential role of activated fibroblasts and reactive oxygen species, mediated by TGF beta 1, allowing the development of antioxidant in the management of the established radiation-induced fibro-atrophy. Cosmetic sequelae are evaluated with standardized scales, such as the LENT-SOMA and must be monitored during at least 5 years. The main factors determining the occurrence of sequelae are a large breast volume, dose heterogeneity and the use of tumour bed boost after whole-breast radiation therapy. Intensity modulated radiotherapy and partial breast irradiation position themselves as a good alternatives to reduce the incidence of late skin side effects. The use of predictive tests of intrinsic radiosensitivity might fit into the therapeutic strategy. (authors)

  19. Late effects of radiation therapy for prostate carcinoma: The patient`s perspective of bladder, bowel and sexual morbidity

    Energy Technology Data Exchange (ETDEWEB)

    Franklin, C.I.V.; Parker, C.A.; Morton, K.M. [Queensland Radium Institute, Herston, QLD (Australia)

    1998-02-01

    The patients` perceptions of the late effects of radiation therapy for carcinoma of the prostate on bladder, bowel and sexual function were determined by using a self-administered questionnaire (included as an appendix) which was posted in June 1996 to patients who had been treated for carcinoma of the prostate between February 1993 and April 1994 at the Herston centre of the Queensland Radium Institute. The questions were based on the SOMA-LENT subjective scales. Moderate bladder morbidity was reported by 15% of patients, with 2% reporting major morbidity. Moderate bowel morbidity was reported by 19% of patients with 2% reporting major morbidity, the major symptoms being bowel urgency and mucus discharge. Sexual function was a problem, with 72% of patients reporting dissatisfaction with their current level of sexual activity. Copyright (1998) Blackwell Science Pty Ltd 12 refs., 5 tabs., 2 figs.

  20. Late effects on normal tissues: oesophagus

    International Nuclear Information System (INIS)

    Pavy, J.J.; Bosset, J.F.

    1997-01-01

    Radiation-induced late effects of oesophagus are observed after treatment of various cancers. Acute reactions, mainly oesophagitis, are well known and accurately described; late effects share, for most of these, a common consequence: alteration of the main oesophageal function, namely to conduct the food bolus; clinically they are impaired in terms of mobility and stenosis. More rarely, ulcerations and pseudodiverticulae can be observed. Chemotherapy further increases the risk of late effects, especially in case of concomitant chemo-radiotherapy. All numbers and statistical data on oesophagus late effects should be regarded with caution due to recent changes in the therapeutic attitudes (more and more combined chemotherapy-radiotherapy) and some progress in given cancer locations. A common scale like the LENT-SOMA should enable the clinician to better know these late effects on oesophagus which is required to initiate effective prevention measures and adapted treatments. (authors)

  1. Late effects of radiation therapy for prostate carcinoma: The patient's perspective of bladder, bowel and sexual morbidity

    International Nuclear Information System (INIS)

    Franklin, C.I.V.; Parker, C.A.; Morton, K.M.

    1998-01-01

    The patients' perceptions of the late effects of radiation therapy for carcinoma of the prostate on bladder, bowel and sexual function were determined by using a self-administered questionnaire (included as an appendix) which was posted in June 1996 to patients who had been treated for carcinoma of the prostate between February 1993 and April 1994 at the Herston centre of the Queensland Radium Institute. The questions were based on the SOMA-LENT subjective scales. Moderate bladder morbidity was reported by 15% of patients, with 2% reporting major morbidity. Moderate bowel morbidity was reported by 19% of patients with 2% reporting major morbidity, the major symptoms being bowel urgency and mucus discharge. Sexual function was a problem, with 72% of patients reporting dissatisfaction with their current level of sexual activity. Copyright (1998) Blackwell Science Pty Ltd

  2. Scaling satan.

    Science.gov (United States)

    Wilson, K M; Huff, J L

    2001-05-01

    The influence on social behavior of beliefs in Satan and the nature of evil has received little empirical study. Elaine Pagels (1995) in her book, The Origin of Satan, argued that Christians' intolerance toward others is due to their belief in an active Satan. In this study, more than 200 college undergraduates completed the Manitoba Prejudice Scale and the Attitudes Toward Homosexuals Scale (B. Altemeyer, 1988), as well as the Belief in an Active Satan Scale, developed by the authors. The Belief in an Active Satan Scale demonstrated good internal consistency and temporal stability. Correlational analyses revealed that for the female participants, belief in an active Satan was directly related to intolerance toward lesbians and gay men and intolerance toward ethnic minorities. For the male participants, belief in an active Satan was directly related to intolerance toward lesbians and gay men but was not significantly related to intolerance toward ethnic minorities. Results of this research showed that it is possible to meaningfully measure belief in an active Satan and that such beliefs may encourage intolerance toward others.

  3. Antimicrobial efficacy assessment of multi-use solution to disinfect hydrophilic contact lens, in vitro Avaliação da ação antimicrobiana de soluções multiuso para desinfecção de lentes de contato hidrofílicas, in vitro

    Directory of Open Access Journals (Sweden)

    Aline Cristina Fioravanti Lui

    2009-10-01

    Full Text Available PURPOSE: To evaluate the efficacy of disinfecting solutions in hydrophilic contact lenses (CL. METHODS: Two multi-use solutions denominated solution A (0.001% polyquaternium-1 and 0.0005% myristamidopropyl dimethylamine and solution B (0.0001% polyaminopropyl biguanide were used. The solutions were tested in hydrophilic contact lenses infected with Pseudomonas aeruginosa (ATCC27583, Staphylococcus epidermidis (ATCC1226, Klebsiella pneumoniae (ATCC13883, Staphylococcus aureus (ATCC25923 and Candida albicans (ATCC 10231 and the decrease in microorganisms growth after the hydrophilic contact lenses were cleaned with the respective solutions was verified. The manufacture's instructions were followed. RESULTS: A decrease of 90% of Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus aureus, Candida albicans and a decrease 100% of Klebsiella pneumoniae was observed. CONCLUSION: The solutions decreased the amount of microorganisms tested.OBJETIVO: Avaliar a influência da ação antimicrobiana das soluções multiuso para desinfecção de lentes de contato hidrofílicas. MÉTODOS: Duas soluções multiuso denominadas solução A (poliquaternário-1 a 0,001% e miristamidopropil dimetilamina a 0,0005% e solução B (poliaminopropil biguanida a 0,0001% foram testadas em lentes de contato hidrofílicas contaminadas com Pseudomonas aeruginosa (ATCC27583, Staphylococcus epidermidis (ATCC1226, Klebsiella pneumoniae (ATCC13883, Staphylococcus aureus (ATCC25923 e Candida albicans (ATCC 10231 para verificar a quantidade de redução do crescimento dos microrganismos após o enxágue com as soluções. Foram seguidas as instruções preconizadas pelos fabricantes. RESULTADOS: Houve redução de 90% do crescimento de Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus aureus e Candida albicans. Não houve crescimento de Klebsiella pneumoniae. CONCLUSÃO: As soluções testadas neste trabalho mostraram redução do número de

  4. Bloqueio extraconal para facectomia com implante de lente intra-ocular: influência do fentanil associado ao anestésico local na qualidade do bloqueio e na analgesia pós-operatória Bloqueo extraconal para facectomia con implantación de lente intra-ocular: influencia del fentanil asociado al anestésico local en la calidad del bloqueo y en la analgesia pos-operatoria Extraconal block for cataract extraction surgery with implantation of intraocular lens: contribution of fentanyl associated to local anesthetics for quality of block and postoperative analgesia

    Directory of Open Access Journals (Sweden)

    Daniel Espada Lahoz

    2003-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A anestesia locorregional para cirurgias oftalmológicas oferece vantagens, como: mínimas alterações fisiológicas, anestesia completa, bloqueio dos reflexos oculares, pequena incidência de náuseas e vômitos, menor tempo de recuperação e analgesia pós-operatória. A preocupação constante com a qualidade do bloqueio, assim como da abordagem da analgesia pós-operatória deve ficar sob a responsabilidade do anestesiologista. O objetivo deste estudo foi avaliar se o fentanil contribui na qualidade do bloqueio extraconal e na analgesia pós-operatória de facectomias com implante de lente intra-ocular. MÉTODO: Estudou-se a associação do fentanil e bupivacaína a 0,75% na qualidade do bloqueio ocular e na analgesia pós-operatória em 164 pacientes submetidos a facectomia com implante de lente intra-ocular (técnica extracapsular, de ambos os sexos com homogeneidade de parâmetros antropométricos, olho operado, classificação do estado físico (ASA e índice de risco cardíaco de Goldman. Os pacientes foram distribuídos em dois grupos (82 pacientes em cada grupo por sorteio de forma aleatória, com e sem fentanil. Avaliou-se a qualidade do bloqueio por: aparecimento da dor no per-operatório, manutenção de movimentação das pálpebras ou do globo ocular, persistência do reflexo de Bell, número de bloqueios realizados para a obtenção de condições cirúrgicas e avaliação do bloqueio pelo cirurgião. A analgesia pós-operatória foi avaliada pela necessidade de complementação analgésica pelo paciente. RESULTADOS: Fentanil associado à solução anestésica no bloqueio extraconal aumentou significativamente o bloqueio do músculo reto medial (com fentanil - 17,1%, sem fentanil - 32,9% e diminuiu o consumo de analgésicos no período pós-operatório (uso de analgésicos com fentanil - 20,7%, não uso de analgésicos com fentanil - 41,5%. CONCLUSÕES: Nas condições deste estudo o fentanil

  5. Nuclear scales

    International Nuclear Information System (INIS)

    Friar, J.L.

    1998-01-01

    Nuclear scales are discussed from the nuclear physics viewpoint. The conventional nuclear potential is characterized as a black box that interpolates nucleon-nucleon (NN) data, while being constrained by the best possible theoretical input. The latter consists of the longer-range parts of the NN force (e.g., OPEP, TPEP, the π-γ force), which can be calculated using chiral perturbation theory and gauged using modern phase-shift analyses. The shorter-range parts of the force are effectively parameterized by moments of the interaction that are independent of the details of the force model, in analogy to chiral perturbation theory. Results of GFMC calculations in light nuclei are interpreted in terms of fundamental scales, which are in good agreement with expectations from chiral effective field theories. Problems with spin-orbit-type observables are noted

  6. Nuclear scales

    Energy Technology Data Exchange (ETDEWEB)

    Friar, J.L.

    1998-12-01

    Nuclear scales are discussed from the nuclear physics viewpoint. The conventional nuclear potential is characterized as a black box that interpolates nucleon-nucleon (NN) data, while being constrained by the best possible theoretical input. The latter consists of the longer-range parts of the NN force (e.g., OPEP, TPEP, the {pi}-{gamma} force), which can be calculated using chiral perturbation theory and gauged using modern phase-shift analyses. The shorter-range parts of the force are effectively parameterized by moments of the interaction that are independent of the details of the force model, in analogy to chiral perturbation theory. Results of GFMC calculations in light nuclei are interpreted in terms of fundamental scales, which are in good agreement with expectations from chiral effective field theories. Problems with spin-orbit-type observables are noted.

  7. Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial.

    Science.gov (United States)

    Tang, Yamei; Rong, Xiaoming; Hu, Weihan; Li, Guoqian; Yang, Xiaoxia; Yang, Jianhua; Xu, Pengfei; Luo, Jinjun

    2014-11-01

    Excessive generation of free radicals plays a critical role in the pathogenesis of radiation-induced brain injury. This study was designed to evaluate the protective effect of edaravone, a free radical scavenger, on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma. Eligible patients were randomized 1:1 to the control group and the edaravone group (intravenous 30 mg twice per day for 2 weeks). Both groups received intravenous conventional steroid therapy and were monitored by brain MRI and LENT/SOMA scales prior to the entry of the trial and at 3-months after completing the trial. The primary end point was a 3-month response rate of the proportional changes determined by MRI. The trial is registered at Clinicaltrials.gov Identifier: NCT01865201. Between 2009 and 2012, we enrolled 154 patients. Of whom 137 were eligible for analysis. The volumes of necrosis estimated on T(2)-weighted image showed that 55.6 % edaravone-treated patients (40 out of 72) showed edema decreases ≥25 %, which was significantly higher than that in the control group (35.4 %, 23 out of 65, p = 0.025). Forty-four patients treated with edaravone (61.1 %) reported improvement in neurologic symptoms and signs evaluated by LENT/SOMA scales, while the rate was 38.5 % in the control group (p = 0.006). MRI of the edaravone group showed a significant decrease in area of T(1)-weighted contrast enhancement (1.67 ± 4.69 cm(2), p = 0.004) and the T(2)-weighted edema (5.08 ± 10.32 cm(2), p = 0.000). Moreover, compared with those in control group, patients with edaravone exhibited significantly better radiological improvement measured by T(2)-weighted image (p = 0.042). Administration of edaravone, in adjunct to steroid regimen, might provide a better outcome in patients with radiation-induced brain necrosis.

  8. Assessment of factors connected with radiotherapy influencing the cosmetic effect in breast conserving therapy

    International Nuclear Information System (INIS)

    Blaszczyk, P.; Roszkowski, K.; Blaszczyk, E.; Kowalewski, J.

    2009-01-01

    Aim: To compare cosmetic results of different radiotherapy schedules used in the treatment of breast cancer after breast radiotherapy and to identify factors affecting cosmetic outcomes. Material and methods: Ninety-four patients irradiated. Median follow-up of 29 months (range 18-154 mo.). Patients were treated with standard fractionation 45-50 Gy/20-25 fx/4-5 weeks. Boost up to 10 Gy. Late effects were evaluated using the LENT-SOMA scoring scale. The cosmetic results were assessed on a four-point scale and presence of concomitant chemotherapy. Results: LENT-SOMA grade 3 toxicity was observed only in 8 (8,5%) patients. The factor associated with hyperpigmentation is large breast size. The significant risk factors for teleangiectasia are high dose and use photon energy 1,33 MeV beam. Factors found to impact significantly cosmetics adversely fibrosis was large breast size. Breast fibrosis were more frequent observed in woman after whole dose 50 Gy. There were no differences in breast skin thick between analysed factors. Conclusions: After irradiating large breasts more often than one observes the fibrosis of the breast in the case of small and average breasts and discolour of the skin. Irradiating photons from the cobalt source in the comparison with photons about higher energy at women with large breasts, there is the reason more frequent occurrence of the skin angioma. For the final cosmetic effect of radiotherapy in saving treatment, they do not have the impact: tumor size, boost method, chemical treatment, patients age. (authors)

  9. Radiation Therapy Did Not Induce Long-Term Changes in Rectal Mucosa: Results From the Randomized Scandinavian Prostate Cancer Group 7 Trial

    Energy Technology Data Exchange (ETDEWEB)

    Slagsvold, Jens Erik, E-mail: Jens.Erik.Slagsvold@stolav.no [Cancer Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim (Norway); Viset, Trond [Department of Pathology, St. Olavs Hospital, Trondheim University Hospital, Trondheim (Norway); Wibe, Arne [Institute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim (Norway); Department of Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim (Norway); Kaasa, Stein [Cancer Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim (Norway); European Palliative Care Research Center, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim (Norway); Widmark, Anders [Department of Radiation Sciences, Cancercentrum, Umeå (Sweden); Lund, Jo-Åsmund [Cancer Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim (Norway); European Palliative Care Research Center, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim (Norway)

    2016-07-15

    Purpose: To investigate long-term changes in the rectal mucosa after curative external beam radiation therapy in the treatment of prostate cancer. Methods and Materials: In the Scandinavian Prostate Cancer Group 7 trial, 880 men with locally advanced prostate cancer were randomized to hormonal therapy alone versus hormonal therapy plus radiation therapy to 70 Gy. A subcohort from this trial being randomized at our center (n=178) was invited to a study on late anorectal side effects during 2003-2005, approximately 5 years after treatment, including measuring health-reported quality of life and physician-assessed toxicity score by the Late Effects Normal Tissue Task Force/Subjective, Objective, Management, Analytic (LENT/SOMA) and European Organization for Research and Treatment of Cancer/Radiation Therapy Oncology Group score. Sixty-seven patients had a rectal mucosa biopsy. Sixty-four biopsies were included in the final analysis, of which 33 patients were randomized to hormonal treatment and 31 to hormonal treatment plus radiation therapy. The presence of fibrosis, number of capillaries, and lymphocyte infiltration was then evaluated by light microscopy. Results: The group receiving radiation therapy had significantly higher LENT/SOMA and function/bother scale scores than the group that only received hormonal treatment, but there was no significant difference in the presence of fibrosis, ectasia, number of capillaries in the lamina propria, or lymphocyte infiltration between the groups. Conclusion: Radiation therapy to 70 Gy to the prostate does not induce long-term microscopic mucosal changes in the rectum 5 years after treatment. This is in contrast to the general assumption that structural changes, including fibrosis, seen after radiation therapy include the mucosa. We speculate that the main late effects of radiation therapy on the structure of the rectum are located in the deeper layers of the rectal wall than the mucosa.

  10. Quality of Life Assessment After Concurrent Chemoradiation for Invasive Bladder Cancer: Results of a Multicenter Prospective Study (GETUG 97-015)

    International Nuclear Information System (INIS)

    Lagrange, Jean-Leon; Bascoul-Mollevi, Caroline; Geoffrois, Lionnel; Beckendorf, Veronique; Ferrero, Jean-Marc; Joly, Florence; Allouache, Nedjila; Bachaud, Jean-Marc; Chevreau, Christine; Kramar, Andrew; Chauvet, Bruno

    2011-01-01

    Purpose: To evaluate bladder preservation and functional quality after concurrent chemoradiotherapy for muscle-invasive cancer in 53 patients included in a Phase II trial. Patient and Methods: Pelvic irradiation delivered 45Gy, followed by an 18-Gy boost. Concurrent chemotherapy with cisplatin and 5-fluorouracil by continuous infusion was performed at Weeks 1, 4, and 7 during radiotherapy. Patients initially suitable for surgery were evaluated with macroscopically complete transurethral resection after 45Gy, followed by radical cystectomy in case of incomplete response. The European Organization for Research and Treatment of Cancer quality of life questionnaire QLQ-C30, specific items on bladder function, and the Late Effects in Normal Tissues-Subjective, Objective, Management, and Analytic (LENT-SOMA) symptoms scale were used to evaluate quality of life before treatment and 6, 12, 24, and 36 months after treatment. Results: Median age was 68 years for 51 evaluable patients. Thirty-two percent of patients had T2a tumors, 46% T2b, 16% T3, and 6% T4. A visibly complete transurethral resection was possible in 66%. Median follow-up was 8 years. Bladder was preserved in 67% (95% confidence interval, 52-79%) of patients. Overall survival was 36% (95% confidence interval, 23-49%) at 8 years for all patients, and 45% (28-61%) for the 36 patients suitable for surgery. Satisfactory bladder function, according to LENT-SOMA, was reported for 100% of patients with preserved bladder and locally controlled disease 6-36 months after the beginning of treatment. Satisfactory bladder function was reported for 35% of patients before treatment and for 43%, 57%, and 29%, respectively, at 6, 18, and 36 months. Conclusions: Concurrent chemoradiation therapy allowed bladder preservation with tumor control for 67% patients at 8 years. Quality of life and quality of bladder function were satisfactory for 67% of patients.

  11. Toward integrating psyche and soma: psychoanalysis and neurobiology.

    Science.gov (United States)

    Flannery, J; Taylor, G

    1981-02-01

    The brain is the "key organ" for understanding mind/body/illness relationships. During the past two decades neurobiological research has generated a plethora of new data and concepts which have increased tremendously our knowledge of the functioning brain. As a result the psychoanalytic view of the relationship between mind and brain may seem at risk of becoming outmoded. Yet while psychoanalytic theory may no longer be wholly tenable, psychoanalysis continues to offer interesting and heuristically valuable isomorphic models of cortical function. On the other hand neurobiology provides a corrective influence on psychoanalytic concept-building, causing theory to be refined as it is tested against the results of research. One possible result of interdisciplinary cross-fertilization is that a revised theory of the function of dreams and fantasy may throw light on the vicissitudes of somatic experience, and the pathogenesis of psychophysiological disorder.

  12. Commentary on "Trauma to the Psyche and Soma"

    Science.gov (United States)

    Bryant, Richard A.; Hopwood, Sally

    2006-01-01

    This case report addresses assessment and treatment considerations for a patient suffering from posttraumatic stress disorder (PTSD) in the context of mild traumatic brain injury and ongoing pain. Management of this case is based on the application of evidence-based therapy, and of cognitive behaviour therapy, for PTSD reduction. Assessment and…

  13. Meditation, Mindfulness, Psyche and Soma: Eastern, Western Perspectives

    DEFF Research Database (Denmark)

    Singla, Rashmi; Jordanov, Daniel; Autrup, Mads

    This presentation focuses on the genesis of meditation and mindfulness in the East for comprehension of these phenomena, which are increasingly applied and adapted in the current Western context. Their very origin from the East, particularly Buddhism and Yoga practices, directs our attention...... to the three major assumptions about human nature; the monoism between mind and body, the centrality of consciousness and meditation as a part of daily conduct. The mainstream Western understandings promoting the body-mind dualism are challenged by invoking the bodily experiences and consciousness emphasising...... is perceived as a way of resisting dualisms and binaries regarding psychological, physical, social and spiritual realities. We conclude that without a holistic, integrated understanding of the basic principles and assumptions in which meditation and mindfulness are embedded, there is a risk for these phenomena...

  14. Self Organized Multi Agent Swarms (SOMAS) for Network Security Control

    Science.gov (United States)

    2009-03-01

    A. Van Veldhuizen . Evolutionary Algorithms for Solving Multi-Objective Problems, chapter MOEA Parallelization. Springer, 2007. 37. Das, Subrata...Mike P. and Willem-Jan van den Heuvel. Service Oriented Architectures: Approaches, Technologies, and Research Issues. Technical report, Tilburg...Tanenbaum, Andrew S. and Maarten Van Steen. Distributed Systems: Principles and Paradigms. Prentice Hall, 2006. 128. Thomas, Tavaris J. Fire Ant: An

  15. Imaging the Visceral Soma: A Corporeal Feminist Interpretation

    African Journals Online (AJOL)

    denise

    interdependence of our inner biology or viscerality with the socio-cultural inscriptions of embodiment. In this .... nature/culture or sex/gender model of conceptualising sexual ..... (brain), knee or torso, and these various body-parts are enclosed ...

  16. Condições de adaptação e venda de lentes de contato em óticas do estado de São Paulo Conditions of contact lens fitting and sale by optician stores São Paulo state

    Directory of Open Access Journals (Sweden)

    Andrea Cotait Kara José

    2001-10-01

    Full Text Available Objetivo: Avaliar as condições de adaptação e venda de lentes de contato (LC em óticas de quatro cidades do Estado de São Paulo, Brasil. Métodos: Realizou-se estudo por meio de respostas a um questionário aplicado por quatro estudantes de Medicina em óticas situadas em várias cidades do Estado de São Paulo. Foram obtidos dados sobre a necessidade da apresentação de receita médica para a compra das LC, os tipos de LC vendidas/adaptadas, o profissional que orienta a venda e/ou adaptação, os equipamentos usados no teste de tolerância, a conduta do cliente diante de complicações quando da adaptação da LC ou durante o uso, orientação quanto a possíveis sinais e sintomas de perigo, as doenças que contra-indiquem o uso e a higiene do usuário, as horas de uso e a possibilidade de pernoite. Resultados: Das 198 óticas pesquisadas, 121 (61,11% vendem LC. Não foi necessária receita médica para a compra das lentes em 112 óticas (92,56%, sendo que nessas, a graduação era determinada pela medida dos óculos em 69 (61,61% casos e por relato verbal em 28 (25,00% casos. Quanto aos equipamentos, 102 (91,07% óticas possuíam lensômetro; 41 (36,61% possuíam ceratômetro e 14 (12,50%, lâmpada de fenda. Lentes descartáveis hidrofílicas foram encontradas para venda/adaptação em 66 (54,55% óticas; lentes hidrofílicas de uso prolongado ou diário em 68 (56,20% e lentes rígidas, em 54 (44,63%. Em 103 (85,12% óticas, foram feitos testes de tolerância, sendo os responsáveis pelo atendimento e pela monitorização dos testes os profissionais autodenominados contatólogos em 78 (64,46% dessas óticas, balconista em 20 (16,53%, óptico em 12 (9,92% e oftalmologistas em 9 (7,44%. Quanto às complicações na adaptação, em 66 (54,55% óticas, afirmou-se que elas só ocorreriam, se evidenciadas no teste de tolerância; em 35 (28,93%, aconselhou-se tratamento com oftalmologista e em 20 (16,53%, sugeriu-se o retorno à ótica para

  17. Molecular scale

    Directory of Open Access Journals (Sweden)

    Christopher H. Childers

    2016-03-01

    Full Text Available This manuscript demonstrates the molecular scale cure rate dependence of di-functional epoxide based thermoset polymers cured with amines. A series of cure heating ramp rates were used to determine the influence of ramp rate on the glass transition temperature (Tg and sub-Tg transitions and the average free volume hole size in these systems. The networks were comprised of 3,3′-diaminodiphenyl sulfone (33DDS and diglycidyl ether of bisphenol F (DGEBF and were cured at ramp rates ranging from 0.5 to 20 °C/min. Differential scanning calorimetry (DSC and NIR spectroscopy were used to explore the cure ramp rate dependence of the polymer network growth, whereas broadband dielectric spectroscopy (BDS and free volume hole size measurements were used to interrogate networks’ molecular level structural variations upon curing at variable heating ramp rates. It was found that although the Tg of the polymer matrices was similar, the NIR and DSC measurements revealed a strong correlation for how these networks grow in relation to the cure heating ramp rate. The free volume analysis and BDS results for the cured samples suggest differences in the molecular architecture of the matrix polymers due to cure heating rate dependence.

  18. SOMA TÉRMICA PARA O SUBPERÍODO SEMEADURA-MATURAÇÃO DE FEIJÃO CV. CARIOCA EM COLORADO DO OESTE, RONDÔNIA ACCUMULATED HEAT UNIT FOR THE BEAN CV. ‘CARIOCA’ SOWING-MATURATION SUB-PERIOD IN COLORADO DO OESTE, RONDÔNIA STATE, BRAZIL

    Directory of Open Access Journals (Sweden)

    Marcelo Notti Miranda

    2010-05-01

    Full Text Available

    Determinou-se a soma térmica, expressa em graus-dia, para o subperíodo semeadura-maturação do feijoeiro comum, cultivar Carioca. O estudo foi desenvolvido com base em dados fenológicos de experimentos de campo, realizados no período de entressafra, com o uso de irrigação, no ano de 2006, e no período de safra normal, com e sem o uso de irrigação, no ano de 2007. Os experimentos foram conduzidos no Instituto Federal de Rondônia (IFRO, no município de Colorado do Oeste, Estado de Rondônia. A soma dos graus-dia (GD foi determinada utilizando-se dois métodos: o primeiro considerando-se três diferentes temperaturas-base inferiores (Tb, 10°C, 12°C e 15°C, e o segundo tomando-se as temperaturas-base inferiores 10°C, 12°C e 15°C e a temperatura-base superior (TB de 35°C. Os valores diários da temperatura do ar foram obtidos na estação meteorológica do IFRO, instalada próxima aos locais dos experimentos. Os métodos não apresentaram diferença significativa entre si, fornecendo valores médios que variaram de 686 a 1.261,9 graus-dia, com Tb de 15°C, para o período de safra normal com irrigação, e de 10°C, para o período de entressafra, respectivamente. Pelos resultados obtidos, evidencia-se que as condições de soma térmica, para o cultivo do feijão, são favoráveis, principalmente no período de safra normal com irrigação.

    A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients

    International Nuclear Information System (INIS)

    Kiltie, A.E.; Ryan, A.J.; Swindell, R.; Barber, J.B.P.; West, C.M.L.; Magee, B.; Hendry, J.H.

    1999-01-01

    Background and purpose: Prediction of late normal tissue reactions to radiotherapy would permit tailoring of dosage to each patient. Measurement of residual DNA double strand breaks using pulsed field gel electrophoresis (PFGE) shows promise in this field. The aim of this study was to test the predictive potential of PFGE in a group of retrospectively studied breast cancer patients.Materials and methods: Thirty nine patients, treated uniformly for breast cancer 9-15 years previously, with excision of the tumour and radiotherapy to the breast and drainage areas, were assessed clinically using the LENT SOMA scale, and a 5-mm punch biopsy taken from the buttock. Fibroblast cell strains were established and used to study residual DNA double strand breaks, using PFGE.Results: There were significant correlations between the DNA assay results and the fibrosis score (r s =0.46; P=0.003), the combined fibrosis and retraction score (r s =0.45, P=0.004) and the overall LENT score (r s =0.43; P=0.006). Using polychotomous logistic regression, the fibroblast DNA assay result was an independent prognostic factor for fibrosis severity.Conclusions: There is a relationship between residual radiation-induced DNA damage in fibroblasts and the severity of the late normal tissue damage seen in the patients from whom the cells were cultured. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  19. Implante de lente intraocular en niños como solución a los problemas sociales de la ceguera por catarata congénita Intraocular lens implants for children as a solution to social problems caused by blindness from congenital cataract

    Directory of Open Access Journals (Sweden)

    Rosa María Naranjo Fernández

    2011-12-01

    Full Text Available Se estima en alrededor de 1,5 millones el número de niños con baja visión o ciegos legales, alrededor del mundo, con una prevalencia de 1 a 4 por cada 10 000 niños en los países industrializados y de 5 a 15 en los países en vías de desarrollo. La prevalencia de la ceguera infantil en América Latina es de 0,6 %, lo cual representa 900 niños por cada millón de habitantes que necesitan asistencia para visión baja. La prevalencia de ceguera por catarata congénita puede estar entre 1 y 4 por cada 10 000 niños en países subdesarrollados y entre 0,1 a 0,4 en países industrializados. En Cuba con una población de 2,1 millones de habitantes menores de 15 años la catarata congénita es considerada la segunda causa de ceguera infantil. En los últimos 20 años ha revolucionado completamente el tratamiento quirúrgico de la catarata en niños, por el desarrollo alcanzado en el perfeccionamiento de las técnicas quirúrgicas. En nuestro país la cirugía de catarata pediátrica con implante de lente intraocular comenzó en el año 1990, posterior a la inauguración del centro de Microcirugía Ocular en el año 1988. Queda demostrada la importancia de la cirugía de catarata pediátrica con implante de lente intraocular, como una solución a los problemas sociales ocasionados por el déficit visual del paciente no tratado oportunamente, con la aplicación de tecnología moderna se logra mejorar la calidad de vida de los niños, tanto social como educacional, incorporándolos de una forma activa a la sociedad.It is estimated that around 1,5 million children with low vision or legally blind exist worldwide, with a prevalence of 1 to 4 per 10 000 children in the industrialized countries and of 5 to 15 in the developing countries. The prevalence rate of the infantile blindness in Latin America is 0,6 %, which represents 900 children per one million inhabitants who need medical assistance due to low vision. The prevalence of blindness due to

  1. CURVAS PARALELAS EXPLÍCITAS DE LAS CURVAS CÓNICAS NO DEGENERADAS PARA EL TORNEADO CNC DE LENTES Y ESPEJOS ASFÉRICO-CÓNICOS EXPLICIT PARALLEL CURVES OF NON-DEGENERATE CONIC CURVES FOR THE TURNED CNC OF ASPHERIC-CONIC LENSES AND MIRORS

    Directory of Open Access Journals (Sweden)

    Juan Camilo Valencia

    2008-12-01

    Full Text Available Este artículo presenta el método para obtener, en coordenadas cartesianas, las líneas curvas paralelas de las curvas cónicas no degeneradas, por métodos analíticos y numéricos. Se define el offset como una función paralela a la función original a una distancia r. El offset de una cónica es importante para los procesos de fabricación de mecanismos, lentes, espejos y moldes; especialmente en el torneado con control numérico computarizado (CNC de superficies de revolución con secciones cónicas, usando buriles de diamante con punta de radio r. También se presenta una técnica refinada usando interpolación circular segmentaria para construir numéricamente el offset de una parábola, que también puede usarse como modelo para determinar el offset de la elipse y de la hipérbola.This paper presents the method to obtain, in Cartesian coordinates, the parallel curve lines of non-degenerate conical curves, by analytical and numerical methods. Offset is defined as parallel function to the original function to a distance r. Offset of a conic is important for the manufacturing processes of mechanisms, lenses, mirrors, and molds; especially in the turning with computerized numerical control (CNC of surfaces of revolution with conical sections, using diamond tools of radio r. Also a refined tip technique using segmental circular interpolation to numerically construct the parabola offset is presented, that also can be used as model to determine offsets of ellipse and hyperbola.

  2. O cálculo do poder das lentes intra-oculares e o Orbscan-II. Parte 1: O poder óptico da córnea normal Power calculation of intraocular lenses and the Orbscan-II. Part 1: The power of the normal cornea

    Directory of Open Access Journals (Sweden)

    Érika C. Canarim de Oliveira

    2003-10-01

    Full Text Available OBJETIVO: Avaliar o poder dióptrico da porção central da córnea normal. MÉTODOS: Análise retrospectiva da topografia por varredura de fenda de luz e disco de Plácido em 30 olhos normais. RESULTADOS: Os poderes médios ceratométrico, anterior, da espessura e total; ópticos ceratométrico e total; axiais ceratométrico e total; tangencial total, equivalente e a soma do poder médio de ambas superfícies foram semelhantes (p>0,8361 nas quatro áreas centrais analisadas (0,04, 1, 3 e 5 mm de diâmetro. O poder médio posterior diminuiu de -6,62 D até -6,35 D (p=0,0030. A espessura média aumentou de 524 µm até 554 µm (p=0,0231, representando 0,13 D do poder total da córnea. Os poderes óptico (p0,4907 e à soma do poder de ambas superfícies (p>0,3868. O poder médio anterior foi ao redor de 7,5 vezes maior que o poder médio posterior. CONCLUSÕES: O poder real da córnea calculado usando ambas superfícies, sua espessura e os índices de refração fisiológicos é menor que o poder convencionalmente aceito e determinado pela medição da curvatura da superfície anterior e o índice de refração ceratométrico da córnea (FPURPOSE: To evaluate the dioptric power of the normal central cornea. METHODS: Retrospective analysis of combined slit-scanning and Placido-ring topography in 30 normal eyes. RESULTS: Keratometric-mean, anterior-mean, thickness-mean, and total-mean powers; keratometric-optical and total-optical, keratometric-axial and total-axial, and total-tangential powers; equivalent power and the addition of anterior and posterior mean powers, were similar (p>0.8361 in the four analyzed central areas with 0.04, 1.0, 3.0, and 5.0 mm diameter. The posterior-mean power decreased (p=0.0030 from -6.62 D to -6.35 D. The average thickness increased (p=0.0231 from 524 µm to 554 µm, representing 0.13 D of total-mean corneal power. Keratometric-optical (p0.4907, and to the addition of anterior-mean and posterior-mean powers (p>0

  3. Contribution to the study of the interaction of slow neutrons with {sup 235}U using the time-of-flight method; Contribution a l'etude par la methode du temps de vol de l'interaction de neutrons lents avec l'U{sup 235}

    Energy Technology Data Exchange (ETDEWEB)

    Michaudon, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-05-15

    This study concerns the properties of the excited levels of uranium 236 obtained by interaction of slow neutron with uranium 235. The experiments have been carried out at the Saclay linear electron accelerator by use of the time of flight method. In the first part of this paper, we examine the technical and physical conditions which rule the experiments: compromise between resolution and counting rate, time dispersion due to the slowing down of the neutrons and crystalline binding effects. In a second part the experimental results i.e. total, fission and ternary fission cross sections are given. The third part deals with the analysis of these results: the resonance parameters determination ({tau}{sub n}, {tau}{sub {gamma}}, {tau}{sub f}), the study of their statistical distribution and of their correlations. We tried some classifications of the resonances according to their parameters and compared these classifications to each other and to other results. At least the evidence of a cross section correlation with a range smaller than 100 eV seems to be confirmed. (author) [French] Cette etude porte sur les proprietes des niveaux excites de l'Uranium-236 obtenus par l'interaction de neutrons lents avec le {sup 235}U. La technique experimentale est celle de la spectrometrie par temps de vol, les experiences ayant ete realisees aupres de l'accelerateur lineaire d'electrons de Saclay, Dans une premiere partie nous examinons les donnees techniques et physiques conditionnant les experiences: compromis entre resolution et taux de comptage, dispersion en temps due au ralentissement des neutrons, effet des liaisons cristallines. Dans une deuxieme partie sont exposes les resultats experimentaux: sections efficaces totales, de fission et de fission ternaire du {sup 235}U. Une troisieme partie porte sur l'analyse de ces resultats: determination des parametres ({tau}{sub n}, {tau}{sub {gamma}}, {tau}{sub f}), etude de leurs distributions statistiques et des correlations entre ces

  4. Implantação de lente intraocular com uma alça amputada: proposta para o tratamento cirúrgico da subluxação do cristalino Intraocular lens implantation with one loop haptic amputed: a new propose to the subluxation lens surgical treatment

    Directory of Open Access Journals (Sweden)

    Marcelo Ventura

    2010-04-01

    Full Text Available OBJETIVO: Avaliar os resultados pós-operatórios da subluxação congênita do cristalino, corrigida por uma nova abordagem cirúrgica. MÉTODOS: Foram estudados 21 olhos de 13 pacientes, portadores de subluxação não traumática do cristalino submetidos à cirurgia na Fundação Altino Ventura, no período de abril de 1999 a abril de 2004. A idade média foi de 8,7 ± 5,4 anos, e o tempo médio de seguimento foi 21,5 ± 19,3 meses. Os pacientes foram submetidos à facoaspiração, implante do anel endocapsular e lente intraocular (LIO. Uma das alças da LIO foi amputada e apoiada sobre o anel, no interior do saco capsular, centralizando a LIO. RESULTADOS: Houve melhora da acuidade visual (AV em todos os casos, e redução significante do equivalente esférico e componente esférico comparando-se a refração pré e pós-operatória (pPURPOSE: To evaluate the postoperative results of congenital lens subluxation corrected by a new technique. METHODS: Retrospective chart review of 21 eyes of 13 patients with no traumatic lens subluxation who underwent surgery in Altino Ventura Foundation from April, 1999 to April, 2004. The mean age was 8.7 ± 5.4 years old, and the mean follow-up period was 21.5 ± 19.3 months. Patients underwent phacoaspiration, endocapsular ring and intraocular lens (IOL implantation. The implanted IOL had one loop haptic excised and was supported above the ring, inside the capsular bag promoting intraocular lens centralization. RESULTS: Visual acuity improvement was observed in all cases. There was a significant reduction of the spherical equivalent and spherical component comparing the pre and postoperative refraction (p<0.01. There was no statistically significant difference between the pre and postoperative cylinder component (p=0.71. Posterior capsule opacification was a postoperative complication found in 71.4% of the cases. Early posterior capsulotomy was performed with no complications in these cases. CONCLUSION

  5. Contribution to the study of the interaction of slow neutrons with {sup 235}U using the time-of-flight method; Contribution a l'etude par la methode du temps de vol de l'interaction de neutrons lents avec l'U{sup 235}

    Energy Technology Data Exchange (ETDEWEB)

    Michaudon, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-05-15

    This study concerns the properties of the excited levels of uranium 236 obtained by interaction of slow neutron with uranium 235. The experiments have been carried out at the Saclay linear electron accelerator by use of the time of flight method. In the first part of this paper, we examine the technical and physical conditions which rule the experiments: compromise between resolution and counting rate, time dispersion due to the slowing down of the neutrons and crystalline binding effects. In a second part the experimental results i.e. total, fission and ternary fission cross sections are given. The third part deals with the analysis of these results: the resonance parameters determination ({tau}{sub n}, {tau}{sub {gamma}}, {tau}{sub f}), the study of their statistical distribution and of their correlations. We tried some classifications of the resonances according to their parameters and compared these classifications to each other and to other results. At least the evidence of a cross section correlation with a range smaller than 100 eV seems to be confirmed. (author) [French] Cette etude porte sur les proprietes des niveaux excites de l'Uranium-236 obtenus par l'interaction de neutrons lents avec le {sup 235}U. La technique experimentale est celle de la spectrometrie par temps de vol, les experiences ayant ete realisees aupres de l'accelerateur lineaire d'electrons de Saclay, Dans une premiere partie nous examinons les donnees techniques et physiques conditionnant les experiences: compromis entre resolution et taux de comptage, dispersion en temps due au ralentissement des neutrons, effet des liaisons cristallines. Dans une deuxieme partie sont exposes les resultats experimentaux: sections efficaces totales, de fission et de fission ternaire du {sup 235}U. Une troisieme partie porte sur l'analyse de ces resultats: determination des parametres ({tau}{sub n}, {tau}{sub {gamma}}, {tau}{sub f}), etude de leurs distributions statistiques et

  6. Gestão social sob a lente estruturacionista

    Directory of Open Access Journals (Sweden)

    Miguel Rivera Peres Júnior

    2013-12-01

    Full Text Available A Gestão Social – como campo de estudo e como prática social – tem buscado se consolidar como um tipo de gestão pública não estatal, em que a sociedade é a protagonista da ação. Grande parte dos estudos da área fundamenta-se na perspectiva crítica, em especial na teoria da ação comunicativa de Habermas. Pretende-se, aqui, indicar um novo caminho teórico para a análise da Gestão Social, fundamentado na Teoria da Estruturação, proposta pelo sociólogo inglês Anthony Giddens. Tendo entre seus principais pressupostos a dualidade da estrutura (a estrutura é, ao mesmo tempo, meio e resultado da ação e o reconhecimento da ação humana como intencional, reflexiva e cognoscitiva, entende-se que a perspectiva estruturacionista fornece subsídios consistentes para a compreensão das práticas de Gestão Social, especialmente no que diz respeito ao processo de estruturação do sistema deliberativo e da formação da esfera pública, bases de sustentação teórica da Gestão Social. Para viabilizar essa nova abordagem, este artigo propõe um arcabouço teórico que incorpora o sistema deliberativo de Mansbridge (1999 ao modelo estruturacionista multidimensional de sistemas sociais de Whittington (1992. Neste arcabouço, à semelhança do que foi estabelecido por Whittington (1992 para os demais sistemas sociais, são definidos as regras e os recursos básicos (as propriedades estruturadas na perspectiva giddensiana do sistema deliberativo, respectivamente, argumentação deliberativa e participação dialógica. O arcabouço sugere, ainda, que essas propriedades são, simultaneamente, meio e resultado das práticas de gestão social (entendida como ação gerencial dialógica configurando aquela que é a concepção central da Teoria da Estruturação: a noção de dualidade da estrutura. Com seu framework, Whittington (1992 entende que está “colocando Giddens em ação”, contribuindo para que a Teoria da Estruturação seja utilizada em pesquisas empíricas, não se restringindo às discussões ontológicas. Com a agregação de um sistema deliberativo a esse modelo, acredita-se que se possa contribuir para a consolidação da Gestão Social, estabelecendo uma interface teórica profícua com a Teoria da Estruturação.

  7. Mga Lente sa Likod ng Lente: Isang Panimulang Pag-aaral ng Ilang Litratong Kuha ni Xander Angeles

    Directory of Open Access Journals (Sweden)

    Moreal Nagarit Camba

    2011-12-01

    Full Text Available Ang pangalang Xander Angeles ay kilala bilang isa sa mga in-demand napangalan sa mundo ng fashion at advertisement sa Pilipinas. Kakabit ngpangalang ito ang samut-saring lokal at internasyunal na parangal; idagdag pa rito ang isang advertising company, isang modelling agency, at isang fashion and photography school.

  8. Multicultural counseling self-efficacy scale-racial diversity form: factor structure and test of a social cognitive model.

    Science.gov (United States)

    Sheu, Hung-Bin; Rigali-Oiler, Marybeth; Lent, Robert W

    2012-01-01

    This study was conducted to gather evidence on the factor structure and concurrent criterion validity of the multicultural counseling self-efficacy scale-racial diversity form (MCSE-RD; Sheu & Lent, 2007). The MCSE-RD was designed to assess therapists' perceived capabilities in performing culturally relevant in-session behaviors in cross-racial counseling. Participants were 209 students in counseling-related graduate programs in the USA. Confirmatory factor analyses identified a bifactor structure in which responses to MCSE-RD items could be explained by one generic and three multicultural-specific counseling self-efficacy factors. Support was also found for a social cognitive model in which self-efficacy and interests in multicultural counseling mediated the effects of prior cross-racial client contacts and perceptions of multicultural training environments on intent to perform multicultural counseling in the future. Additionally, outcome expectations were predictive of multicultural counseling interests and choice goals. Implications for multicultural training and directions for future research are highlighted.

  9. Scaling of Metabolic Scaling within Physical Limits

    Directory of Open Access Journals (Sweden)

    Douglas S. Glazier

    2014-10-01

    Full Text Available Both the slope and elevation of scaling relationships between log metabolic rate and log body size vary taxonomically and in relation to physiological or developmental state, ecological lifestyle and environmental conditions. Here I discuss how the recently proposed metabolic-level boundaries hypothesis (MLBH provides a useful conceptual framework for explaining and predicting much, but not all of this variation. This hypothesis is based on three major assumptions: (1 various processes related to body volume and surface area exert state-dependent effects on the scaling slope for metabolic rate in relation to body mass; (2 the elevation and slope of metabolic scaling relationships are linked; and (3 both intrinsic (anatomical, biochemical and physiological and extrinsic (ecological factors can affect metabolic scaling. According to the MLBH, the diversity of metabolic scaling relationships occurs within physical boundary limits related to body volume and surface area. Within these limits, specific metabolic scaling slopes can be predicted from the metabolic level (or scaling elevation of a species or group of species. In essence, metabolic scaling itself scales with metabolic level, which is in turn contingent on various intrinsic and extrinsic conditions operating in physiological or evolutionary time. The MLBH represents a “meta-mechanism” or collection of multiple, specific mechanisms that have contingent, state-dependent effects. As such, the MLBH is Darwinian in approach (the theory of natural selection is also meta-mechanistic, in contrast to currently influential metabolic scaling theory that is Newtonian in approach (i.e., based on unitary deterministic laws. Furthermore, the MLBH can be viewed as part of a more general theory that includes other mechanisms that may also affect metabolic scaling.

  10. Flux scaling: Ultimate regime

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Flux scaling: Ultimate regime. With the Nusselt number and the mixing length scales, we get the Nusselt number and Reynolds number (w'd/ν) scalings: and or. and. scaling expected to occur at extremely high Ra Rayleigh-Benard convection. Get the ultimate regime ...

  11. To scale or not to scale

    DEFF Research Database (Denmark)

    Svendsen, Morten Bo Søndergaard; Christensen, Emil Aputsiaq Flindt; Steffensen, John Fleng

    2017-01-01

    Conventionally, dynamic energy budget (DEB) models operate with animals that have maintenance rates scaling with their body volume, and assimilation rates scaling with body surface area. However, when applying such criteria for the individual in a population level model, the emergent behaviour...

  12. Necrotizing nocardial scleritis after combined penetrating keratoplasty and phacoemulsification with intraocular lens implantation: a case report and review of the literature Esclerite necrosante por Nocardia após ceratoplastia penetrante e facoemulsificação com implante de lente intra-ocular: caso clínico e revisão de literatura

    Directory of Open Access Journals (Sweden)

    Jerome Charles Ramos-Esteban

    2007-03-01

    Full Text Available We report the history and clinical presentation of an 88-year-old female with Fuchs dystrophy who developed an acute anterior necrotizing scleritis in her left eye 23 months after an uncomplicated combined penetrating keratoplasty and phacoemulsification with intraocular lens implantation which progressed to slceral perforation with uveal prolapses. The patient underwent a complete systemic work-up for both autoimmune and infectious causes of scleritis. Surgical specimens of the area of scleral perforation were sent for histology and microbiologic studies. Analysis of surgical specimens revealed the presence of culture-proven Nocardia asteroides as a causative agent for the patient's scleral perforation. Results of her systemic autoimmune work-up were not conclusive. Successful treatment with tectonic scleral reinforcement with donor corneal tissue and preserved pericardium, oral and topical trimethoprim-sulfamethoxazole and topical amikacin salvaged the globe and increased vision. The patient's final best-corrected visual acuity sixteen months after her last operation remains 20/70. Prompt surgical intervention with submission of appropriate specimens for pathological diagnosis and microbiology, along with consultation with rheumatologic and infectious disease specialists, are mandatory to minimize visual loss in cases of suspected infectious necrotizing scleritis.Relato de caso de esclerite necrosante aguda, evoluindo para perfuração escleral com prolapso uveal, 23 meses após procedimento de ceratoplastia penetrante e facoemulsificação com implante de lente intra-ocular no olho esquerdo sem intercorrências.A paciente foi submetida à avaliação completa auto-imune para esclerite. Biópsia da área de perfuração escleral foi encaminhada para avaliação patológica e microbiológica. Análise de material cirúrgico revelou presença de cultura proveniente de Nocardia asteroides como agente causal da perfuração escleral. Resultados de

  13. A implementação do sistema de custos proposto pelo governo federal: uma análise sob a ótica institucional Aplicación del sistema de gastos del gobierno federal: un análisis según una lente institucional Implementing costs systems proposed by federal government: an analysis under a institutional lens

    Directory of Open Access Journals (Sweden)

    Thiago Bernardo Borges

    2013-04-01

    Full Text Available As informações sobre custos no setor público são importantes para uma análise adequada de eficiência e qualidade do gasto. Em países de referência a implementação dessa metodologia teve caráter mais abrangente, não focado apenas em questões técnicas. A teoria institucional discute justamente a necessidade de que tais transformações no cotidiano dos servidores devem envolver ajustes das normas, valores e práticas em uso nas organizações envolvidas. Neste contexto é que se insere este trabalho, que procurou através da ótica institucional, e comparando com o processo de reforma australiano, analisar como se desenvolveu no governo federal brasileiro a incorporação de novas ferramentas de gestão. Assim, identificou-se, diferentemente do que sugere a teoria institucional e a experiência internacional, que o governo brasileiro optou pela implantação de uma solução tecnológica, em detrimento de uma mobilização institucional mais ampla.La información sobre los costos en el sector público son importantes para un correcto análisis de la eficiencia y calidad del gasto. En referencia a los países que aplican esta metodología tuvo un enfoque más extenso, no sólo se centró en cuestiones técnicas. La teoría institucional argumenta sobre la necesidad de tales transformaciones en las situaciones cotidianas de lós servidores debe implicar ajustes de las normas, los valores y las prácticas en uso en las organizaciones. En este contexto, En este contexto, es que este trabajo se ajusta a esa búsqueda a través de la lente institucional, y comparando con el proceso de reforma del gobierno de Australia, analizar cómo se desarrolló en el gobierno federal brasileño la incorporación de nuevas herramientas de gestión. Por lo tanto, fue identificado de forma diferente que sugiere la teoría institucional y la experiencia internacional, que el gobierno brasileño optó por implementar una solución tecnológica, en lugar de

  14. Resultados del implante múltiple de lentes intraoculares en la cirugía de catarata en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer" Results of the multiple intraocular lenses implantation in the cataract surgery performed at "Ramón Pando Ferrer" Cuban Institute of Ophthalmology

    Directory of Open Access Journals (Sweden)

    Eric Montero Díaz

    2010-06-01

    Full Text Available OBJETIVO: Valorar los resultados visuales de los pacientes operados con la técnica de piggy back o implantes múltiples de lentes intraoculares. MÉTODOS: Se realizó un estudio descriptivo retrospectivo de corte transversal en el que se tomaron 32 ojos de 30 pacientes del universo operado de catarata, con la técnica antes descrita, en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer", en el período comprendido entre enero de 2000 hasta diciembre de 2006. Fueron evaluadas algunas variables demográficas, como edad y sexo, así como agudeza visual y refracción preoperatorio y posoperatoria con cristales y sin ellos. Reportamos las complicaciones transquirúrgicas y posquirúrgicas asociadas a las diferentes técnicas quirúrgicas empleadas para la extracción del cristalino. RESULTADOS: La edad promedio obtenida fue mayor de 50 años, y predominó el sexo femenino. Parte de los pacientes tuvieron una agudeza visual corregida superior a 20/40. La complicación más frecuente fue la opacidad de la cápsula posterior y solo en la tercera parte de los pacientes se obtuvo una buena corrección refractiva. CONCLUSIONES: La técnica de piggy back permitió la recuperación de cuatro líneas en la cartilla de Snellen en la agudeza visual corregida, mientras que en la agudeza visual sin corrección solo aumentó en dos líneas. Se encontró igual número de pacientes hipocorregidos y bien corregidos.OBJECTIVE: To asses the visual results of patients operated on by piggy back technique or multiple implantation of intraocular lenses METHODS: A retrospective cross-sectional descriptive study was conducted in 32 eyes from 30 patients operated on from cataract, using the above-mentioned technique, at "Ramon Pando Ferrer" Cuban Institute of Ophthalmology in the period January 2000 through December 2006. Some demographic variables as age and sex as well as visual acuity and preoperative and postoperative refraction with/without lenses were evaluated

  15. Atlantic Salmon Scale Measurements

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Scales are collected annually from smolt trapping operations in Maine as wellas other sampling opportunities (e.g. marine surveys, fishery sampling etc.). Scale...

  16. Concepts of scale

    NARCIS (Netherlands)

    Padt, F.J.G.; Arts, B.J.M.

    2014-01-01

    This chapter provides some clarity to the scale debate. It bridges a variety of approaches, definitions and jargons used in various disciplines in order to provide common ground for a concept of scale as a basis for scale-sensitive governance of the environment. The chapter introduces the concept of

  17. Optimal renormalization scales and commensurate scale relations

    International Nuclear Information System (INIS)

    Brodsky, S.J.; Lu, H.J.

    1996-01-01

    Commensurate scale relations relate observables to observables and thus are independent of theoretical conventions, such as the choice of intermediate renormalization scheme. The physical quantities are related at commensurate scales which satisfy a transitivity rule which ensures that predictions are independent of the choice of an intermediate renormalization scheme. QCD can thus be tested in a new and precise way by checking that the observables track both in their relative normalization and in their commensurate scale dependence. For example, the radiative corrections to the Bjorken sum rule at a given momentum transfer Q can be predicted from measurements of the e+e - annihilation cross section at a corresponding commensurate energy scale √s ∝ Q, thus generalizing Crewther's relation to non-conformal QCD. The coefficients that appear in this perturbative expansion take the form of a simple geometric series and thus have no renormalon divergent behavior. The authors also discuss scale-fixed relations between the threshold corrections to the heavy quark production cross section in e+e - annihilation and the heavy quark coupling α V which is measurable in lattice gauge theory

  18. Large scale electrolysers

    International Nuclear Information System (INIS)

    B Bello; M Junker

    2006-01-01

    Hydrogen production by water electrolysis represents nearly 4 % of the world hydrogen production. Future development of hydrogen vehicles will require large quantities of hydrogen. Installation of large scale hydrogen production plants will be needed. In this context, development of low cost large scale electrolysers that could use 'clean power' seems necessary. ALPHEA HYDROGEN, an European network and center of expertise on hydrogen and fuel cells, has performed for its members a study in 2005 to evaluate the potential of large scale electrolysers to produce hydrogen in the future. The different electrolysis technologies were compared. Then, a state of art of the electrolysis modules currently available was made. A review of the large scale electrolysis plants that have been installed in the world was also realized. The main projects related to large scale electrolysis were also listed. Economy of large scale electrolysers has been discussed. The influence of energy prices on the hydrogen production cost by large scale electrolysis was evaluated. (authors)

  19. Scaling of differential equations

    CERN Document Server

    Langtangen, Hans Petter

    2016-01-01

    The book serves both as a reference for various scaled models with corresponding dimensionless numbers, and as a resource for learning the art of scaling. A special feature of the book is the emphasis on how to create software for scaled models, based on existing software for unscaled models. Scaling (or non-dimensionalization) is a mathematical technique that greatly simplifies the setting of input parameters in numerical simulations. Moreover, scaling enhances the understanding of how different physical processes interact in a differential equation model. Compared to the existing literature, where the topic of scaling is frequently encountered, but very often in only a brief and shallow setting, the present book gives much more thorough explanations of how to reason about finding the right scales. This process is highly problem dependent, and therefore the book features a lot of worked examples, from very simple ODEs to systems of PDEs, especially from fluid mechanics. The text is easily accessible and exam...

  20. Small scale models equal large scale savings

    International Nuclear Information System (INIS)

    Lee, R.; Segroves, R.

    1994-01-01

    A physical scale model of a reactor is a tool which can be used to reduce the time spent by workers in the containment during an outage and thus to reduce the radiation dose and save money. The model can be used for worker orientation, and for planning maintenance, modifications, manpower deployment and outage activities. Examples of the use of models are presented. These were for the La Salle 2 and Dresden 1 and 2 BWRs. In each case cost-effectiveness and exposure reduction due to the use of a scale model is demonstrated. (UK)

  1. Scale and scaling in agronomy and environmental sciences

    Science.gov (United States)

    Scale is of paramount importance in environmental studies, engineering, and design. The unique course covers the following topics: scale and scaling, methods and theories, scaling in soils and other porous media, scaling in plants and crops; scaling in landscapes and watersheds, and scaling in agro...

  2. Biomicroscopia ultra-sônica na avaliação da posição das lentes intra-oculares em uma técnica de fixação escleral Ultrasound biomicroscopy in the assessment of the intraocular lenses positioning in a transscleral fixation technique

    Directory of Open Access Journals (Sweden)

    Raul de Camargo Vianna Filho

    2000-10-01

    Full Text Available Objetivo: Avaliar pela biomicrospia ultra-sônica (UBM o posicionamento, em relação ao sulco ciliar, das alças de lentes intra-oculares (LIO, em uma técnica de fixação escleral, avaliando-se também se dois pontos de fixação são suficientes para que não haja inclinação da parte óptica. Métodos: Dezesseis olhos afácicos foram submetidos a implante LIO por uma mesma técnica de fixação escleral, realizados por um mesmo cirurgião. Um mês após a cirurgia, o posicionamento das alças das LIO foram avaliados pelo UBM, assim como distâncias entre as LIO e córnea. Os resultados foram submetidos a testes estatísticos. Resultados: Das 32 alças fixadas à esclera, oito estavam localizadas no sulco ciliar e 24 fora deste. Não houve diferença estatística nas distâncias entre LIO e córnea para alças posicionadas no sulco ciliar quando comparadas àquelas localizadas fora do sulco. Isto sugere que, além da distância ao limbo que se transfixa a esclera, outros fatores devem estar associados ao posicionamento da alça no sulco ciliar. As medidas LIO -- córnea realizadas na periferia das LIO às 3, 6, 9, e 12 horas foram semelhantes, mostrando que dois pontos de fixação são suficientes para que a LIO não fique inclinada. Conclusões: Outros fatores (por exemplo o ângulo de abertura do corpo ciliar, além da distância ao limbo na qual se transfixa a esclera, são importantes para o posicionamento das alças no sulco ciliar. Dois pontos de fixação são suficientes para que a LIO não apresente inclinação dentro do olho.Purpose: To assess, through ultrasound biomicroscopy (UBM, the positioning of the intraocular lenses (IOL haptics as related to the ciliary sulcus by using a scleral fixation technique; and to evaluate, as well, if two fixation points are sufficient to avoid tilting of the lenses. Methods: Sixteen aphakic eyes underwent an IOL implan-tation by means of the same scleral fixation technique, performed by the

  3. Influência da soma térmica e da chuva durante o desenvolvimento de laranjas-'Valência' e 'Natal' na relação entre sólidos solúveis e acidez e no índice tecnológico do suco Influence of the accumulated heat unit and rainfall on the ratio and technological index of sweet oranges 'Valência' and 'Natal'

    Directory of Open Access Journals (Sweden)

    CLOVIS ALBERTO VOLPE

    2002-08-01

    Full Text Available Este trabalho foi realizado com o objetivo de conhecer a influência que algumas variáveis meteorológicas exercem na razão entre sólidos solúveis totais e acidez total titulável ("ratio" e no índice tecnológico dos frutos da primeira florada das laranjeiras-'Natal' e 'Valência', na região de Bebedouro-SP, mediante a utilização de métodos estatísticos de regressão. Foram utilizados dados de amostragens de rotina para o processamento industrial durante 4 anos, os quais permitiram desenvolver equações de regressão linear e quadrática, com a soma térmica (graus-dia como variável independente, e de regressão múltipla, utilizando graus-dia e chuva como variáveis independentes. A equação de melhor ajuste para o índice tecnológico foi a quadrática, enquanto para o "ratio" a equação linear apresentou o melhor ajuste. A temperatura do ar, representada por graus-dia, foi a variável que exerceu maior influência nos indicadores de qualidade dos frutos.This study aimed to know the influence of some meteorological variables on the ratio and technological index for oranges provided from 'Natal' and 'Valencia' orchards, from field plots, located at Bebedouro - São Paulo - Brazil. The quality indicators, ratio and technological index, were obtained from routine processing plant tests. These parameters were related to the meteorological variables: degree-day and rainfall. In order to determine which independent variable had a stronger influence on the fruit quality indicators, single and multiple linear regressions analysis were applied. The results have shown that technological index is better described by a quadratic function, and ratio is better described by a linear regression, as function of independent variables. The statistical analysis have indicated that the air temperature, expressed by accumulated degree day, is the meteorological aspect that had greater influence in fruit quality indicators.

  4. Scale of Critical Thinking

    OpenAIRE

    Semerci, Nuriye

    2000-01-01

    The main purpose of this study is to develop the scale for critical thinking. The Scale of Critical Thinking was applied to 200 student. In this scale, there are total 55 items, four of which are negative and 51 of which are positive. The KMO (Kaiser-Meyer-Olkin) value is 0.75, the Bartlett test value is 7145.41, and the Cronbach Alpha value is 0.90.

  5. Comparison between OPD-scan results and contrast sensitivity of three intraocular lenses: spheric AcrySof SN60AT, aspheric AcrySof SN60WF and multifocal AcrySof Restor lens Estudo comparativo da análise de frente de onda e sensibilidade ao contraste entre as lentes intra-oculares multifocal AcrySof Restor SN60D3, monofocal AcrySof SN60WF asférica e a monofocal SN60AT esférica

    Directory of Open Access Journals (Sweden)

    Celso Takashi Nakano

    2009-08-01

    ção com implantes de lentes intraoculares AcrySof SN60D3 multifocal, AcrySof SN60WF monofocal asférica e AcrySof SA60AT monofocal esférica. Métodos: Trinta e dois olhos com a lente intraocular multifocal, 32 olhos com a lente intraocular monofocal asférica e 32 olhos com a lente intraocular monofocal esférica. A avaliação oftalmológica foi realizada no primeiro, terceiro, sétimo, e nonagésimo dia pós-operatório. Todos os exames foram padronizados, realizada por um único examinador sob condições controladas de luminosidade fotópicas estabelecidas em 85 cd/m², medida por meio de tabelas de ETDRS, sensibilidade ao contraste e análise de aberrometria com OPD-Scan. Resultados: As médias de aberração total foi superior no grupo SN60AT (KW = 9.42; p=0.009 quando comparada com o grupo SN60D3 (p=0.016 e o grupo SN60WF (p=0.0047. O grupo SN60AT (KW = 16.20; p=0.0003 apresentou superioridade nas medias de aberração esférica comparada com o grupo SN60WF (p=0.00046 e o grupo SN60D3 (p=0.0014. Nenhuma diferença significante foi encontrada na acuidade visual para longe com e sem correção óptica com a tabela de ETDRS a 100% e 9% de contraste. O grupo SN60D3 comparada a SN60AT (p=0.016 apresentou baixa sensibilidade ao contraste em condições fotópicas com diferença estatística a 6.0 cpg (KW = 7.84; p=0.0199, mas sem diferença estatística entre os grupos SN60WF e SN60AT (p=0.91 e entre os grupos SN60WF e SN60D3 (p=0.051. O grupo SN60D3 apresentou baixa sensibilidade ao contraste em condições mesópicas (KW = 10.79; p=0,0045 a 6cpg quando comparada com o grupos SN60AT (p=0.011 e SN60WF (p=0.007. Conclusão: As lentes intraoculares multifocais e asféricas apresentaram menos aberração esférica quando comparadas à lente intraocular esférica, além da prevista multifocalidade sem correção para longe e perto. Entretanto, o grupo multifocal apresentou baixa sensibilidade ao contraste.

  6. Maximum likely scale estimation

    DEFF Research Database (Denmark)

    Loog, Marco; Pedersen, Kim Steenstrup; Markussen, Bo

    2005-01-01

    A maximum likelihood local scale estimation principle is presented. An actual implementation of the estimation principle uses second order moments of multiple measurements at a fixed location in the image. These measurements consist of Gaussian derivatives possibly taken at several scales and/or ...

  7. Pre-Kindergarten Scale.

    Science.gov (United States)

    Flynn, Tim

    This 25-item scale for rating prekindergarten children concerns personal and cognitive skills. Directions for using the scale are provided. Personal skills include personal hygiene, communication skills, eating habits, relationships with the teacher, peer relations, and personal behavior. Cognitive skills rated are verbal skills, object…

  8. Scales of Progress

    Science.gov (United States)

    Jung, Lee Ann

    2018-01-01

    What is Goal Attainment Scaling? In this article, Lee Ann Jung defines it as a way to measure a student's progress toward an individualized goal. Instead of measuring a skill at a set time (for instance, on a test or other assignment), Goal Attainment Scaling tracks the steps a student takes over the course of a year in a targeted skill. Together,…

  9. Magnetron injection gun scaling

    International Nuclear Information System (INIS)

    Lawson, W.

    1988-01-01

    Existing analytic design equations for magnetron injection guns (MIG's) are approximated to obtain a set of scaling laws. The constraints are chosen to examine the maximum peak power capabilities of MIG's. The scaling laws are compared with exact solutions of the design equations and are supported by MIG simulations

  10. Image scaling curve generation

    NARCIS (Netherlands)

    2012-01-01

    The present invention relates to a method of generating an image scaling curve, where local saliency is detected in a received image. The detected local saliency is then accumulated in the first direction. A final scaling curve is derived from the detected local saliency and the image is then

  11. Image scaling curve generation.

    NARCIS (Netherlands)

    2011-01-01

    The present invention relates to a method of generating an image scaling curve, where local saliency is detected in a received image. The detected local saliency is then accumulated in the first direction. A final scaling curve is derived from the detected local saliency and the image is then

  12. Scales and erosion

    Science.gov (United States)

    There is a need to develop scale explicit understanding of erosion to overcome existing conceptual and methodological flaws in our modelling methods currently applied to understand the process of erosion, transport and deposition at the catchment scale. These models need to be based on a sound under...

  13. Parallel Computing in SCALE

    International Nuclear Information System (INIS)

    DeHart, Mark D.; Williams, Mark L.; Bowman, Stephen M.

    2010-01-01

    The SCALE computational architecture has remained basically the same since its inception 30 years ago, although constituent modules and capabilities have changed significantly. This SCALE concept was intended to provide a framework whereby independent codes can be linked to provide a more comprehensive capability than possible with the individual programs - allowing flexibility to address a wide variety of applications. However, the current system was designed originally for mainframe computers with a single CPU and with significantly less memory than today's personal computers. It has been recognized that the present SCALE computation system could be restructured to take advantage of modern hardware and software capabilities, while retaining many of the modular features of the present system. Preliminary work is being done to define specifications and capabilities for a more advanced computational architecture. This paper describes the state of current SCALE development activities and plans for future development. With the release of SCALE 6.1 in 2010, a new phase of evolutionary development will be available to SCALE users within the TRITON and NEWT modules. The SCALE (Standardized Computer Analyses for Licensing Evaluation) code system developed by Oak Ridge National Laboratory (ORNL) provides a comprehensive and integrated package of codes and nuclear data for a wide range of applications in criticality safety, reactor physics, shielding, isotopic depletion and decay, and sensitivity/uncertainty (S/U) analysis. Over the last three years, since the release of version 5.1 in 2006, several important new codes have been introduced within SCALE, and significant advances applied to existing codes. Many of these new features became available with the release of SCALE 6.0 in early 2009. However, beginning with SCALE 6.1, a first generation of parallel computing is being introduced. In addition to near-term improvements, a plan for longer term SCALE enhancement

  14. Allometric Scaling in Biology

    Science.gov (United States)

    Banavar, Jayanth

    2009-03-01

    The unity of life is expressed not only in the universal basis of inheritance and energetics at the molecular level, but also in the pervasive scaling of traits with body size at the whole-organism level. More than 75 years ago, Kleiber and Brody and Proctor independently showed that the metabolic rates, B, of mammals and birds scale as the three-quarter power of their mass, M. Subsequent studies showed that most biological rates and times scale as M-1/4 and M^1/4 respectively, and that these so called quarter-power scaling relations hold for a variety of organisms, from unicellular prokaryotes and eukaryotes to trees and mammals. The wide applicability of Kleiber's law, across the 22 orders of magnitude of body mass from minute bacteria to giant whales and sequoias, raises the hope that there is some simple general explanation that underlies the incredible diversity of form and function. We will present a general theoretical framework for understanding the relationship between metabolic rate, B, and body mass, M. We show how the pervasive quarter-power biological scaling relations arise naturally from optimal directed resource supply systems. This framework robustly predicts that: 1) whole organism power and resource supply rate, B, scale as M^3/4; 2) most other rates, such as heart rate and maximal population growth rate scale as M-1/4; 3) most biological times, such as blood circulation time and lifespan, scale as M^1/4; and 4) the average velocity of flow through the network, v, such as the speed of blood and oxygen delivery, scales as M^1/12. Our framework is valid even when there is no underlying network. Our theory is applicable to unicellular organisms as well as to large animals and plants. This work was carried out in collaboration with Amos Maritan along with Jim Brown, John Damuth, Melanie Moses, Andrea Rinaldo, and Geoff West.

  15. Small scale optics

    CERN Document Server

    Yupapin, Preecha

    2013-01-01

    The behavior of light in small scale optics or nano/micro optical devices has shown promising results, which can be used for basic and applied research, especially in nanoelectronics. Small Scale Optics presents the use of optical nonlinear behaviors for spins, antennae, and whispering gallery modes within micro/nano devices and circuits, which can be used in many applications. This book proposes a new design for a small scale optical device-a microring resonator device. Most chapters are based on the proposed device, which uses a configuration know as a PANDA ring resonator. Analytical and nu

  16. Scale-relativistic cosmology

    International Nuclear Information System (INIS)

    Nottale, Laurent

    2003-01-01

    The principle of relativity, when it is applied to scale transformations, leads to the suggestion of a generalization of fundamental dilations laws. These new special scale-relativistic resolution transformations involve log-Lorentz factors and lead to the occurrence of a minimal and of a maximal length-scale in nature, which are invariant under dilations. The minimal length-scale, that replaces the zero from the viewpoint of its physical properties, is identified with the Planck length l P , and the maximal scale, that replaces infinity, is identified with the cosmic scale L=Λ -1/2 , where Λ is the cosmological constant.The new interpretation of the Planck scale has several implications for the structure and history of the early Universe: we consider the questions of the origin, of the status of physical laws at very early times, of the horizon/causality problem and of fluctuations at recombination epoch.The new interpretation of the cosmic scale has consequences for our knowledge of the present universe, concerning in particular Mach's principle, the large number coincidence, the problem of the vacuum energy density, the nature and the value of the cosmological constant. The value (theoretically predicted ten years ago) of the scaled cosmological constant Ω Λ =0.75+/-0.15 is now supported by several different experiments (Hubble diagram of Supernovae, Boomerang measurements, gravitational lensing by clusters of galaxies).The scale-relativity framework also allows one to suggest a solution to the missing mass problem, and to make theoretical predictions of fundamental energy scales, thanks to the interpretation of new structures in scale space: fractal/classical transitions as Compton lengths, mass-coupling relations and critical value 4π 2 of inverse couplings. Among them, we find a structure at 3.27+/-0.26x10 20 eV, which agrees closely with the observed highest energy cosmic rays at 3.2+/-0.9x10 20 eV, and another at 5.3x10 -3 eV, which corresponds to the

  17. Beyond KNO scaling

    International Nuclear Information System (INIS)

    Hegyi, S.

    1998-01-01

    A generalization of the Koba-Nielsen-Olesen scaling law of the multiplicity distributions P(n) is presented. It consists of a change in the normalization point of P(n) compensated by a suitable change in the renormalized parameters and a rescaling. The iterative repetition of the transformation yields the sequence of higher-order moment distributions of P(n). Each member of this sequence may exhibit data collapsing behavior in case of violation of the original KNO scaling hypothesis. It is shown that the iterative procedure can be viewed as varying the collision energy, i.e. the moment distributions of P(n) can represent the pattern of pre-asymptotic KNO scaling violation. The fixed points of the iteration will be determined and a consistency test based on Feynman scaling is to be given. (author)

  18. Understanding scaling laws

    International Nuclear Information System (INIS)

    Lysenko, W.P.

    1986-01-01

    Accelerator scaling laws how they can be generated, and how they are used are discussed. A scaling law is a relation between machine parameters and beam parameters. An alternative point of view is that a scaling law is an imposed relation between the equations of motion and the initial conditions. The relation between the parameters is obtained by requiring the beam to be matched. (A beam is said to be matched if the phase-space distribution function is a function of single-particle invariants of the motion.) Because of this restriction, the number of independent parameters describing the system is reduced. Using simple models for bunched- and unbunched-beam situations. Scaling laws are shown to determine the general behavior of beams in accelerators. Such knowledge is useful in design studies for new machines such as high-brightness linacs. The simple model presented shows much of the same behavior as a more detailed RFQ model

  19. Scale-Dependent Grasp

    OpenAIRE

    Kaneko, Makoto; Shirai, Tatsuya; Tsuji, Toshio

    2000-01-01

    This paper discusses the scale-dependent grasp.Suppose that a human approaches an object initially placed on atable and finally achieves an enveloping grasp. Under such initialand final conditions, he (or she) unconsciously changes the graspstrategy according to the size of objects, even though they havesimilar geometry. We call the grasp planning the scale-dependentgrasp. We find that grasp patterns are also changed according tothe surface friction and the geometry of cross section in additi...

  20. Estimation of the incidence of late bladder and rectum complications after high-dose (70-78 Gy) conformal radiotherapy for prostate cancer, using dose-volume histograms

    International Nuclear Information System (INIS)

    Boersma, Liesbeth J.; Brink, Mandy van den; Bruce, Allison M.; Shouman, Tarek; Gras, Luuk; Velde, Annet te; Lebesque, Joos V.

    1998-01-01

    Purpose: To investigate whether Dose-Volume Histogram (DVH) parameters can be used to identify risk groups for developing late gastrointestinal (GI) and genitourinary (GU) complications after conformal radiotherapy for prostate cancer. Methods and Materials: DVH parameters were analyzed for 130 patients with localized prostate cancer, treated with conformal radiotherapy in a dose-escalating protocol (70-78 Gy, 2 Gy per fraction). The incidence of late (>6 months) GI and GU complications was classified using the RTOG/EORTC and the SOMA/LENT scoring system. In addition, GI complications were divided in nonsevere and severe (requiring one or more laser treatments or blood transfusions) rectal bleeding. The median follow-up time was 24 months. We investigated whether rectal and bladder wall volumes, irradiated to various dose levels, correlated with the observed actuarial incidences of GI and GU complications, using volume as a continuous variable. Subsequently, for each dose level in the DVH, the rectal wall volumes were dichotomized using different volumes as cutoff levels. The impact of the total radiation dose, and the maximum radiation dose in the rectal and bladder wall was analyzed as well. Results: The actuarial incidence at 2 years for GI complications ≥Grade II was 14% (RTOG/EORTC) or 20% (SOMA/LENT); for GU complications ≥Grade III 8% (RTOG/EORTC) or 21% (SOMA/LENT). Neither for GI complications ≥Grade II (RTOG/EORTC or SOMA/LENT), nor for GU complications ≥Grade III (RTOG/EORTC or SOMA/LENT), was a significant correlation found between any of the DVH parameters and the actuarial incidence of complications. For severe rectal bleeding (actuarial incidence at 2 years 3%), four consecutive volume cutoff levels were found, which significantly discriminated between high and low risk. A trend was observed that a total radiation dose ≥ 74 Gy (or a maximum radiation dose in the rectal wall >75 Gy) resulted in a higher incidence of severe rectal bleeding (p

  1. Fast ignition breakeven scaling

    International Nuclear Information System (INIS)

    Slutz, Stephen A.; Vesey, Roger Alan

    2005-01-01

    A series of numerical simulations have been performed to determine scaling laws for fast ignition break even of a hot spot formed by energetic particles created by a short pulse laser. Hot spot break even is defined to be when the fusion yield is equal to the total energy deposited in the hot spot through both the initial compression and the subsequent heating. In these simulations, only a small portion of a previously compressed mass of deuterium-tritium fuel is heated on a short time scale, i.e., the hot spot is tamped by the cold dense fuel which surrounds it. The hot spot tamping reduces the minimum energy required to obtain break even as compared to the situation where the entire fuel mass is heated, as was assumed in a previous study [S. A. Slutz, R. A. Vesey, I. Shoemaker, T. A. Mehlhorn, and K. Cochrane, Phys. Plasmas 7, 3483 (2004)]. The minimum energy required to obtain hot spot break even is given approximately by the scaling law E T = 7.5(ρ/100) -1.87 kJ for tamped hot spots, as compared to the previously reported scaling of E UT = 15.3(ρ/100) -1.5 kJ for untamped hotspots. The size of the compressed fuel mass and the focusability of the particles generated by the short pulse laser determines which scaling law to use for an experiment designed to achieve hot spot break even

  2. Scales of gravity

    International Nuclear Information System (INIS)

    Dvali, Gia; Kolanovic, Marko; Nitti, Francesco; Gabadadze, Gregory

    2002-01-01

    We propose a framework in which the quantum gravity scale can be as low as 10 -3 eV. The key assumption is that the standard model ultraviolet cutoff is much higher than the quantum gravity scale. This ensures that we observe conventional weak gravity. We construct an explicit brane-world model in which the brane-localized standard model is coupled to strong 5D gravity of infinite-volume flat extra space. Because of the high ultraviolet scale, the standard model fields generate a large graviton kinetic term on the brane. This kinetic term 'shields' the standard model from the strong bulk gravity. As a result, an observer on the brane sees weak 4D gravity up to astronomically large distances beyond which gravity becomes five dimensional. Modeling quantum gravity above its scale by the closed string spectrum we show that the shielding phenomenon protects the standard model from an apparent phenomenological catastrophe due to the exponentially large number of light string states. The collider experiments, astrophysics, cosmology and gravity measurements independently point to the same lower bound on the quantum gravity scale, 10 -3 eV. For this value the model has experimental signatures both for colliders and for submillimeter gravity measurements. Black holes reveal certain interesting properties in this framework

  3. Universities scale like cities.

    Directory of Open Access Journals (Sweden)

    Anthony F J van Raan

    Full Text Available Recent studies of urban scaling show that important socioeconomic city characteristics such as wealth and innovation capacity exhibit a nonlinear, particularly a power law scaling with population size. These nonlinear effects are common to all cities, with similar power law exponents. These findings mean that the larger the city, the more disproportionally they are places of wealth and innovation. Local properties of cities cause a deviation from the expected behavior as predicted by the power law scaling. In this paper we demonstrate that universities show a similar behavior as cities in the distribution of the 'gross university income' in terms of total number of citations over 'size' in terms of total number of publications. Moreover, the power law exponents for university scaling are comparable to those for urban scaling. We find that deviations from the expected behavior can indeed be explained by specific local properties of universities, particularly the field-specific composition of a university, and its quality in terms of field-normalized citation impact. By studying both the set of the 500 largest universities worldwide and a specific subset of these 500 universities--the top-100 European universities--we are also able to distinguish between properties of universities with as well as without selection of one specific local property, the quality of a university in terms of its average field-normalized citation impact. It also reveals an interesting observation concerning the working of a crucial property in networked systems, preferential attachment.

  4. Universities scale like cities.

    Science.gov (United States)

    van Raan, Anthony F J

    2013-01-01

    Recent studies of urban scaling show that important socioeconomic city characteristics such as wealth and innovation capacity exhibit a nonlinear, particularly a power law scaling with population size. These nonlinear effects are common to all cities, with similar power law exponents. These findings mean that the larger the city, the more disproportionally they are places of wealth and innovation. Local properties of cities cause a deviation from the expected behavior as predicted by the power law scaling. In this paper we demonstrate that universities show a similar behavior as cities in the distribution of the 'gross university income' in terms of total number of citations over 'size' in terms of total number of publications. Moreover, the power law exponents for university scaling are comparable to those for urban scaling. We find that deviations from the expected behavior can indeed be explained by specific local properties of universities, particularly the field-specific composition of a university, and its quality in terms of field-normalized citation impact. By studying both the set of the 500 largest universities worldwide and a specific subset of these 500 universities--the top-100 European universities--we are also able to distinguish between properties of universities with as well as without selection of one specific local property, the quality of a university in terms of its average field-normalized citation impact. It also reveals an interesting observation concerning the working of a crucial property in networked systems, preferential attachment.

  5. Child Development Program Evaluation Scale.

    Science.gov (United States)

    Fiene, Richard J.

    The Child Development Program Evaluation Scale (CDPES) is actually two scales in one, a licensing scale and a quality scale. Licensing predictor items have been found to predict overall compliance of child day care centers with state regulations in four states. Quality scale items have been found to predict the overall quality of child day care…

  6. The INES scale

    International Nuclear Information System (INIS)

    2014-01-01

    This document presents the International Nuclear Event Scale (INES) which has been created to classify nuclear and radiological events in terms of severity. This scale comprises eight levels from 0 to 7, from a slight but noticeable shift with respect to nominal operation to a major accident. Criteria used for incident and accident classification are indicated; they are based on consequences outside the site, consequences within the site, degradation of in-depth defence. The benefit and weaknesses of this scale are briefly indicated. The major concerned actors are the IAEA, the NEA and the ASN. Some key figures are given (number of declared events and incidents), and a ranking of the main nuclear events is proposed with a brief description of the event: Chernobyl, Fukushima, Kyshtym, Three Mile Island, Sellafield, Tokaimura, Saint-Laurent-des-Eaux. Countries which have adopted INES are indicated, as well as the number of incidents reports in France to the ASN

  7. Wavelets, vibrations and scalings

    CERN Document Server

    Meyer, Yves

    1997-01-01

    Physicists and mathematicians are intensely studying fractal sets of fractal curves. Mandelbrot advocated modeling of real-life signals by fractal or multifractal functions. One example is fractional Brownian motion, where large-scale behavior is related to a corresponding infrared divergence. Self-similarities and scaling laws play a key role in this new area. There is a widely accepted belief that wavelet analysis should provide the best available tool to unveil such scaling laws. And orthonormal wavelet bases are the only existing bases which are structurally invariant through dyadic dilations. This book discusses the relevance of wavelet analysis to problems in which self-similarities are important. Among the conclusions drawn are the following: 1) A weak form of self-similarity can be given a simple characterization through size estimates on wavelet coefficients, and 2) Wavelet bases can be tuned in order to provide a sharper characterization of this self-similarity. A pioneer of the wavelet "saga", Meye...

  8. No-Scale Inflation

    CERN Document Server

    Ellis, John; Nanopoulos, Dimitri V.; Olive, Keith A.

    2016-01-01

    Supersymmetry is the most natural framework for physics above the TeV scale, and the corresponding framework for early-Universe cosmology, including inflation, is supergravity. No-scale supergravity emerges from generic string compactifications and yields a non-negative potential, and is therefore a plausible framework for constructing models of inflation. No-scale inflation yields naturally predictions similar to those of the Starobinsky model based on $R + R^2$ gravity, with a tilted spectrum of scalar perturbations: $n_s \\sim 0.96$, and small values of the tensor-to-scalar perturbation ratio $r < 0.1$, as favoured by Planck and other data on the cosmic microwave background (CMB). Detailed measurements of the CMB may provide insights into the embedding of inflation within string theory as well as its links to collider physics.

  9. No-scale inflation

    Science.gov (United States)

    Ellis, John; Garcia, Marcos A. G.; Nanopoulos, Dimitri V.; Olive, Keith A.

    2016-05-01

    Supersymmetry is the most natural framework for physics above the TeV scale, and the corresponding framework for early-Universe cosmology, including inflation, is supergravity. No-scale supergravity emerges from generic string compactifications and yields a non-negative potential, and is therefore a plausible framework for constructing models of inflation. No-scale inflation yields naturally predictions similar to those of the Starobinsky model based on R+{R}2 gravity, with a tilted spectrum of scalar perturbations: {n}s∼ 0.96, and small values of the tensor-to-scalar perturbation ratio r\\lt 0.1, as favoured by Planck and other data on the cosmic microwave background (CMB). Detailed measurements of the CMB may provide insights into the embedding of inflation within string theory as well as its links to collider physics.

  10. Inverse scale space decomposition

    DEFF Research Database (Denmark)

    Schmidt, Marie Foged; Benning, Martin; Schönlieb, Carola-Bibiane

    2018-01-01

    We investigate the inverse scale space flow as a decomposition method for decomposing data into generalised singular vectors. We show that the inverse scale space flow, based on convex and even and positively one-homogeneous regularisation functionals, can decompose data represented...... by the application of a forward operator to a linear combination of generalised singular vectors into its individual singular vectors. We verify that for this decomposition to hold true, two additional conditions on the singular vectors are sufficient: orthogonality in the data space and inclusion of partial sums...... of the subgradients of the singular vectors in the subdifferential of the regularisation functional at zero. We also address the converse question of when the inverse scale space flow returns a generalised singular vector given that the initial data is arbitrary (and therefore not necessarily in the range...

  11. Finite size scaling theory

    International Nuclear Information System (INIS)

    Rittenberg, V.

    1983-01-01

    Fischer's finite-size scaling describes the cross over from the singular behaviour of thermodynamic quantities at the critical point to the analytic behaviour of the finite system. Recent extensions of the method--transfer matrix technique, and the Hamiltonian formalism--are discussed in this paper. The method is presented, with equations deriving scaling function, critical temperature, and exponent v. As an application of the method, a 3-states Hamiltonian with Z 3 global symmetry is studied. Diagonalization of the Hamiltonian for finite chains allows one to estimate the critical exponents, and also to discover new phase transitions at lower temperatures. The critical points lambda, and indices v estimated for finite-scaling are given

  12. Spatial ecology across scales.

    Science.gov (United States)

    Hastings, Alan; Petrovskii, Sergei; Morozov, Andrew

    2011-04-23

    The international conference 'Models in population dynamics and ecology 2010: animal movement, dispersal and spatial ecology' took place at the University of Leicester, UK, on 1-3 September 2010, focusing on mathematical approaches to spatial population dynamics and emphasizing cross-scale issues. Exciting new developments in scaling up from individual level movement to descriptions of this movement at the macroscopic level highlighted the importance of mechanistic approaches, with different descriptions at the microscopic level leading to different ecological outcomes. At higher levels of organization, different macroscopic descriptions of movement also led to different properties at the ecosystem and larger scales. New developments from Levy flight descriptions to the incorporation of new methods from physics and elsewhere are revitalizing research in spatial ecology, which will both increase understanding of fundamental ecological processes and lead to tools for better management.

  13. X and Y scaling

    International Nuclear Information System (INIS)

    West, G.B.

    1988-01-01

    Although much of the intuition for interpreting the high energy data as scattering from structureless constituents came from nuclear physics (and to a lesser extent atomic physics) virtually no data existed for nuclear targets in the non-relativistic regime until relatively recently. It is therefore not so surprising that,in site of the fact that the basic nuclear physics has been well understood for a very long time, the corresponding non-relativistic scaling law was not written down until after the relativistic one,relevant to particle physics, had been explored. Of course, to the extent that these scaling laws simply reflect quasi-elastic scattering of the probe from the constituents, they contain little new physics once the nature of the constitutents is known and understood. On the other hand, deviations from scaling represent corrections to the impulse approximation and can reflect important dynamical and coherent features of the system. Furthermore, as will be discussed in detail here, the scaling curve itself represents the single particle momentum distribution of constituents inside the target. It is therefore prudent to plot the data in terms of a suitable scaling variable since this immediately focuses attention on the dominant physics. Extraneous physics, such as Rutherford scattering in the case of electrons, or magnetic scattering in the case of thermal neutrons is factored out and the use of a scaling variable (such as y) automatically takes into account the fact that the target is a bound state of well-defined constituents. In this talk I shall concentrate almost entirely on non-relativistic systems. Although the formalism applies equally well to both electron scattering from nuclei and thermal neutron scattering from liquids, I shall, because of my background, usually be thinking of the former. On the other hand I shall completely ignore spin considerations so, ironically, the results actually apply more to the latter case!

  14. Elders Health Empowerment Scale

    Science.gov (United States)

    2014-01-01

    Introduction: Empowerment refers to patient skills that allow them to become primary decision-makers in control of daily self-management of health problems. As important the concept as it is, particularly for elders with chronic diseases, few available instruments have been validated for use with Spanish speaking people. Objective: Translate and adapt the Health Empowerment Scale (HES) for a Spanish-speaking older adults sample and perform its psychometric validation. Methods: The HES was adapted based on the Diabetes Empowerment Scale-Short Form. Where "diabetes" was mentioned in the original tool, it was replaced with "health" terms to cover all kinds of conditions that could affect health empowerment. Statistical and Psychometric Analyses were conducted on 648 urban-dwelling seniors. Results: The HES had an acceptable internal consistency with a Cronbach's α of 0.89. The convergent validity was supported by significant Pearson's Coefficient correlations between the HES total and item scores and the General Self Efficacy Scale (r= 0.77), Swedish Rheumatic Disease Empowerment Scale (r= 0.69) and Making Decisions Empowerment Scale (r= 0.70). Construct validity was evaluated using item analysis, half-split test and corrected item to total correlation coefficients; with good internal consistency (α> 0.8). The content validity was supported by Scale and Item Content Validity Index of 0.98 and 1.0, respectively. Conclusions: HES had acceptable face validity and reliability coefficients; which added to its ease administration and users' unbiased comprehension, could set it as a suitable tool in evaluating elder's outpatient empowerment-based medical education programs. PMID:25767307

  15. Scaling law systematics

    International Nuclear Information System (INIS)

    Pfirsch, D.; Duechs, D.F.

    1985-01-01

    A number of statistical implications of empirical scaling laws in form of power products obtained by linear regression are analysed. The sensitivity of the error against a change of exponents is described by a sensitivity factor and the uncertainty of predictions by a ''range of predictions factor''. Inner relations in the statistical material is discussed, as well as the consequences of discarding variables.A recipe is given for the computations to be done. The whole is exemplified by considering scaling laws for the electron energy confinement time of ohmically heated tokamak plasmas. (author)

  16. Tokamak confinement scaling laws

    International Nuclear Information System (INIS)

    Connor, J.

    1998-01-01

    The scaling of energy confinement with engineering parameters, such as plasma current and major radius, is important for establishing the size of an ignited fusion device. Tokamaks exhibit a variety of modes of operation with different confinement properties. At present there is no adequate first principles theory to predict tokamak energy confinement and the empirical scaling method is the preferred approach to designing next step tokamaks. This paper reviews a number of robust theoretical concepts, such as dimensional analysis and stability boundaries, which provide a framework for characterising and understanding tokamak confinement and, therefore, generate more confidence in using empirical laws for extrapolation to future devices. (author)

  17. Rolling at small scales

    DEFF Research Database (Denmark)

    Nielsen, Kim L.; Niordson, Christian F.; Hutchinson, John W.

    2016-01-01

    The rolling process is widely used in the metal forming industry and has been so for many years. However, the process has attracted renewed interest as it recently has been adapted to very small scales where conventional plasticity theory cannot accurately predict the material response. It is well....... Metals are known to be stronger when large strain gradients appear over a few microns; hence, the forces involved in the rolling process are expected to increase relatively at these smaller scales. In the present numerical analysis, a steady-state modeling technique that enables convergence without...

  18. Scaling up Telemedicine

    DEFF Research Database (Denmark)

    Christensen, Jannie Kristine Bang; Nielsen, Jeppe Agger; Gustafsson, Jeppe

    through negotiating, mobilizing coalitions, and legitimacy building. To illustrate and further develop this conceptualization, we build on insights from a longitudinal case study (2008-2014) and provide a rich empirical account of how a Danish telemedicine pilot was transformed into a large......-scale telemedicine project through simultaneous translation and theorization efforts in a cross-sectorial, politicized social context. Although we focus on upscaling as a bottom up process (from pilot to large scale), we argue that translation and theorization, and associated political behavior occurs in a broader...

  19. Analysis of the sum kriging and the kriging sum - a case study; Analise do problema da krigagem da soma e da soma das krigagens - estudo de caso

    Energy Technology Data Exchange (ETDEWEB)

    D' Abbadia, Martinho Romulo Iria

    1999-02-01

    This work presents some thicknesses estimates in overlapped sedimentary sections. The adopted procedure consists of the accomplishment of kriging followed by weighed corrections that provide mathematical consistency to the operation of thicknesses addition. These weighed corrections are based on the proportions between: the thicknesses of the estimated layers and the total thickness of the analyzed section; the standard deviation of the estimation error and the addition of these standard deviations; the variance of the estimation error and the addition of these variances. The proposed method is characterized by its simplicity and operational flexibility, being distinguished by: the number of intervals to be analyzed is theoretically limitless; stationary thicknesses are not required; choice of distinct neighborhoods for each analyzed interval is allowed; it has freedom for the use of distinct models in each investigated interval, making it possible to choose different functions, amplitudes and anisotropies. The technique was applied in an oil field situated in the northeast of Brazil, helping in localising the preferential depositional areas for turbiditic reservoirs and allowing inferences with respect to structural aspects of studied area. (author)

  20. SCALE system driver

    International Nuclear Information System (INIS)

    Petrie, L.M.

    1984-01-01

    The SCALE driver was designed to allow implementation of a modular code system consisting of control modules, which determine the calculation path, and functional modules, which perform the basic calculations. The user can either select a control module and have that module determine the execution path, or the user can select functional modules directly by input

  1. Scaling violation in QCD

    International Nuclear Information System (INIS)

    Furmanski, W.

    1981-08-01

    The effects of scaling violation in QCD are discussed in the perturbative scheme, based on the factorization of mass singularities in the light-like gauge. Some recent applications including the next-to-leading corrections are presented (large psub(T) scattering, numerical analysis of the leptoproduction data). A proposal is made for extending the method on the higher twist sector. (author)

  2. Method of complex scaling

    International Nuclear Information System (INIS)

    Braendas, E.

    1986-01-01

    The method of complex scaling is taken to include bound states, resonances, remaining scattering background and interference. Particular points of the general complex coordinate formulation are presented. It is shown that care must be exercised to avoid paradoxical situations resulting from inadequate definitions of operator domains. A new resonance localization theorem is presented

  3. Civic Engagement Scale

    Directory of Open Access Journals (Sweden)

    Amy Doolittle

    2013-07-01

    Full Text Available This study reports on the development and validation of the Civic Engagement Scale (CES. This scale is developed to be easily administered and useful to educators who are seeking to measure the attitudes and behaviors that have been affected by a service-learning experience. This instrument was administered as a validation study in a purposive sample of social work and education majors at three universities (N = 513 with a return of 354 (69%. After the reliability and validity analysis was completed, the Attitude subscale was left with eight items and a Cronbach’s alpha level of .91. The Behavior subscale was left with six items and a Cronbach’s alpha level of .85. Principal component analysis indicated a two-dimensional scale with high loadings on both factors (mean factor loading for the attitude factor = .79, and mean factor loading for the behavior factor = .77. These results indicate that the CES is strong enough to recommend its use in educational settings. Preliminary use has demonstrated that this scale will be useful to researchers seeking to better understand the relationship of attitudes and behaviors with civic engagement in the service-learning setting. The primary limitations of this research are that the sample was limited to social work and education majors who were primarily White (n = 312, 88.1% and female (n = 294, 83.1%. Therefore, further research would be needed to generalize this research to other populations.

  4. Difficulty scaling through incongruity

    NARCIS (Netherlands)

    Lankveld, van G.; Spronck, P.; Rauterberg, G.W.M.; Mateas, M.; Darken, C.

    2008-01-01

    In this paper we discuss our work on using the incongruity measure from psychological literature to scale the difficulty level of a game online to the capabilities of the human player. Our approach has been implemented in a small game called Glove.

  5. Symbolic Multidimensional Scaling

    NARCIS (Netherlands)

    P.J.F. Groenen (Patrick); Y. Terada

    2015-01-01

    markdownabstract__Abstract__ Multidimensional scaling (MDS) is a technique that visualizes dissimilarities between pairs of objects as distances between points in a low dimensional space. In symbolic MDS, a dissimilarity is not just a value but can represent an interval or even a histogram. Here,

  6. Cardinal scales for health evaluation

    DEFF Research Database (Denmark)

    Harvey, Charles; Østerdal, Lars Peter Raahave

    2010-01-01

    Policy studies often evaluate health for an individual or for a population by using measurement scales that are ordinal scales or expected-utility scales. This paper develops scales of a different type, commonly called cardinal scales, that measure changes in health. Also, we argue that cardinal...... scales provide a meaningful and useful means of evaluating health policies. Thus, we develop a means of using the perspective of early neoclassical welfare economics as an alternative to ordinalist and expected-utility perspectives....

  7. SCALE Code System

    Energy Technology Data Exchange (ETDEWEB)

    Jessee, Matthew Anderson [ORNL

    2016-04-01

    The SCALE Code System is a widely-used modeling and simulation suite for nuclear safety analysis and design that is developed, maintained, tested, and managed by the Reactor and Nuclear Systems Division (RNSD) of Oak Ridge National Laboratory (ORNL). SCALE provides a comprehensive, verified and validated, user-friendly tool set for criticality safety, reactor and lattice physics, radiation shielding, spent fuel and radioactive source term characterization, and sensitivity and uncertainty analysis. Since 1980, regulators, licensees, and research institutions around the world have used SCALE for safety analysis and design. SCALE provides an integrated framework with dozens of computational modules including three deterministic and three Monte Carlo radiation transport solvers that are selected based on the desired solution strategy. SCALE includes current nuclear data libraries and problem-dependent processing tools for continuous-energy (CE) and multigroup (MG) neutronics and coupled neutron-gamma calculations, as well as activation, depletion, and decay calculations. SCALE includes unique capabilities for automated variance reduction for shielding calculations, as well as sensitivity and uncertainty analysis. SCALE’s graphical user interfaces assist with accurate system modeling, visualization of nuclear data, and convenient access to desired results.SCALE 6.2 provides many new capabilities and significant improvements of existing features.New capabilities include:• ENDF/B-VII.1 nuclear data libraries CE and MG with enhanced group structures,• Neutron covariance data based on ENDF/B-VII.1 and supplemented with ORNL data,• Covariance data for fission product yields and decay constants,• Stochastic uncertainty and correlation quantification for any SCALE sequence with Sampler,• Parallel calculations with KENO,• Problem-dependent temperature corrections for CE calculations,• CE shielding and criticality accident alarm system analysis with MAVRIC,• CE

  8. Evolution of Scale Worms

    DEFF Research Database (Denmark)

    Gonzalez, Brett Christopher

    ) caves, and the interstitium, recovering six monophyletic clades within Aphroditiformia: Acoetidae, Aphroditidae, Eulepethidae, Iphionidae, Polynoidae, and Sigalionidae (inclusive of the former ‘Pisionidae’ and ‘Pholoidae’), respectively. Tracing of morphological character evolution showed a high degree...... of adaptability and convergent evolution between relatively closely related scale worms. While some morphological and behavioral modifications in cave polynoids reflected troglomorphism, other modifications like eye loss were found to stem from a common ancestor inhabiting the deep sea, further corroborating...... the deep sea ancestry of scale worm cave fauna. In conclusion, while morphological characterization across Aphroditiformia appears deceptively easy due to the presence of elytra, convergent evolution during multiple early radiations across wide ranging habitats have confounded our ability to reconstruct...

  9. Multiple time scale dynamics

    CERN Document Server

    Kuehn, Christian

    2015-01-01

    This book provides an introduction to dynamical systems with multiple time scales. The approach it takes is to provide an overview of key areas, particularly topics that are less available in the introductory form.  The broad range of topics included makes it accessible for students and researchers new to the field to gain a quick and thorough overview. The first of its kind, this book merges a wide variety of different mathematical techniques into a more unified framework. The book is highly illustrated with many examples and exercises and an extensive bibliography. The target audience of this  book are senior undergraduates, graduate students as well as researchers interested in using the multiple time scale dynamics theory in nonlinear science, either from a theoretical or a mathematical modeling perspective. 

  10. Large scale reflood test

    International Nuclear Information System (INIS)

    Hirano, Kemmei; Murao, Yoshio

    1980-01-01

    The large-scale reflood test with a view to ensuring the safety of light water reactors was started in fiscal 1976 based on the special account act for power source development promotion measures by the entrustment from the Science and Technology Agency. Thereafter, to establish the safety of PWRs in loss-of-coolant accidents by joint international efforts, the Japan-West Germany-U.S. research cooperation program was started in April, 1980. Thereupon, the large-scale reflood test is now included in this program. It consists of two tests using a cylindrical core testing apparatus for examining the overall system effect and a plate core testing apparatus for testing individual effects. Each apparatus is composed of the mock-ups of pressure vessel, primary loop, containment vessel and ECCS. The testing method, the test results and the research cooperation program are described. (J.P.N.)

  11. Dissolution of sulfate scales

    Energy Technology Data Exchange (ETDEWEB)

    Hen, J.

    1991-11-26

    This patent describes a composition for the removal of sulfate scale from surfaces. It comprises: an aqueous solution of about 0.1 to 1.0 molar concentration of an aminopolycarboxylic acid (APCA) containing 1 to 4 amino groups or a salt thereof, and about 0.1 to 1.0 molar concentration of a second component which is diethylenetriaminepenta (methylenephosphonic acid) (DTPMP) or a salt thereof, or aminotri (methylenephosphonic acid) (ATMP) or a salt thereof as an internal phase enveloped by a hydrocarbon membrane phase which is itself emulsified in an external aqueous phase, the hydrocarbon membrane phase continuing a complexing agent weaker for the cations of the sulfate scale than the APCA and DTPMP or ATMP, any complexing agent for the cations in the external aqueous phase being weaker than that in the hydrocarbon membrane phase.

  12. Density scaling for multiplets

    International Nuclear Information System (INIS)

    Nagy, A

    2011-01-01

    Generalized Kohn-Sham equations are presented for lowest-lying multiplets. The way of treating non-integer particle numbers is coupled with an earlier method of the author. The fundamental quantity of the theory is the subspace density. The Kohn-Sham equations are similar to the conventional Kohn-Sham equations. The difference is that the subspace density is used instead of the density and the Kohn-Sham potential is different for different subspaces. The exchange-correlation functional is studied using density scaling. It is shown that there exists a value of the scaling factor ζ for which the correlation energy disappears. Generalized OPM and Krieger-Li-Iafrate (KLI) methods incorporating correlation are presented. The ζKLI method, being as simple as the original KLI method, is proposed for multiplets.

  13. Large scale model testing

    International Nuclear Information System (INIS)

    Brumovsky, M.; Filip, R.; Polachova, H.; Stepanek, S.

    1989-01-01

    Fracture mechanics and fatigue calculations for WWER reactor pressure vessels were checked by large scale model testing performed using large testing machine ZZ 8000 (with a maximum load of 80 MN) at the SKODA WORKS. The results are described from testing the material resistance to fracture (non-ductile). The testing included the base materials and welded joints. The rated specimen thickness was 150 mm with defects of a depth between 15 and 100 mm. The results are also presented of nozzles of 850 mm inner diameter in a scale of 1:3; static, cyclic, and dynamic tests were performed without and with surface defects (15, 30 and 45 mm deep). During cyclic tests the crack growth rate in the elastic-plastic region was also determined. (author). 6 figs., 2 tabs., 5 refs

  14. Urban Scaling in Europe

    Science.gov (United States)

    2016-03-16

    the structural funds for regional development and cohesion . Until recently, several systems of territorial units have coexisted in European...for European MAs versus population. See text and figures 1–7, electronic supplementary material, figures S1–S8 for additional details and electronic...scale as expected, although with wide confidence intervals (table 1). The urbanized area of Spanish cities appears superlinear, contrary to theory

  15. Scaling up Copy Detection

    OpenAIRE

    Li, Xian; Dong, Xin Luna; Lyons, Kenneth B.; Meng, Weiyi; Srivastava, Divesh

    2015-01-01

    Recent research shows that copying is prevalent for Deep-Web data and considering copying can significantly improve truth finding from conflicting values. However, existing copy detection techniques do not scale for large sizes and numbers of data sources, so truth finding can be slowed down by one to two orders of magnitude compared with the corresponding techniques that do not consider copying. In this paper, we study {\\em how to improve scalability of copy detection on structured data}. Ou...

  16. Beyond the Planck Scale

    International Nuclear Information System (INIS)

    Giddings, Steven B.

    2009-01-01

    I outline motivations for believing that important quantum gravity effects lie beyond the Planck scale at both higher energies and longer distances and times. These motivations arise in part from the study of ultra-high energy scattering, and also from considerations in cosmology. I briefly summarize some inferences about such ultra-planckian physics, and clues we might pursue towards the principles of a more fundamental theory addressing the known puzzles and paradoxes of quantum gravity.

  17. Accurate scaling on multiplicity

    International Nuclear Information System (INIS)

    Golokhvastov, A.I.

    1989-01-01

    The commonly used formula of KNO scaling P n =Ψ(n/ ) for descrete distributions (multiplicity distributions) is shown to contradict mathematically the condition ΣP n =1. The effect is essential even at ISR energies. A consistent generalization of the concept of similarity for multiplicity distributions is obtained. The multiplicity distributions of negative particles in PP and also e + e - inelastic interactions are similar over the whole studied energy range. Collider data are discussed. 14 refs.; 8 figs

  18. Gravo-Aeroelastic Scaling for Extreme-Scale Wind Turbines

    Energy Technology Data Exchange (ETDEWEB)

    Fingersh, Lee J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Loth, Eric [University of Virginia; Kaminski, Meghan [University of Virginia; Qin, Chao [University of Virginia; Griffith, D. Todd [Sandia National Laboratories

    2017-06-09

    A scaling methodology is described in the present paper for extreme-scale wind turbines (rated at 10 MW or more) that allow their sub-scale turbines to capture their key blade dynamics and aeroelastic deflections. For extreme-scale turbines, such deflections and dynamics can be substantial and are primarily driven by centrifugal, thrust and gravity forces as well as the net torque. Each of these are in turn a function of various wind conditions, including turbulence levels that cause shear, veer, and gust loads. The 13.2 MW rated SNL100-03 rotor design, having a blade length of 100-meters, is herein scaled to the CART3 wind turbine at NREL using 25% geometric scaling and blade mass and wind speed scaled by gravo-aeroelastic constraints. In order to mimic the ultralight structure on the advanced concept extreme-scale design the scaling results indicate that the gravo-aeroelastically scaled blades for the CART3 are be three times lighter and 25% longer than the current CART3 blades. A benefit of this scaling approach is that the scaled wind speeds needed for testing are reduced (in this case by a factor of two), allowing testing under extreme gust conditions to be much more easily achieved. Most importantly, this scaling approach can investigate extreme-scale concepts including dynamic behaviors and aeroelastic deflections (including flutter) at an extremely small fraction of the full-scale cost.

  19. The ''invisible'' radioactive scale

    International Nuclear Information System (INIS)

    Bjoernstad, T.; Ramsoey, T.

    1999-04-01

    Production and up-concentration of naturally occurring radioactive material (NORM) in the petroleum industry has attracted steadily increasing attention during the last 15 years. Most production engineers today associate this radioactivity with precipitates (scales) and sludges in production tubing, pumps, valves, separators, settling tanks etc., wherever water is being transported or treated. 226 Ra and 228 Ra are the most well known radioactive constituents in scale. Surprisingly little known is the radioactive contamination by 210 Pb and progeny 210 Bi and 210 Po. These are found in combination with 226 Ra in ordinary scale, often in layer of non-radioactive metallic lead in water transportation systems, but also in pure gas and condensate handling systems ''unsupported'' by 226 Ra, but due to transportation and decay of the noble gas 222 Rn in NG/LNG. This latter contamination may be rather thin, in some cases virtually invisible. When, in addition, the radiation energies are low enough for not being detectable on the equipment outer surface, its existence has for most people in the industry been a secret. The report discusses transportation and deposition mechanisms, detection methods and provides some examples of measured results from the North Sea on equipment sent for maintenance. It is concluded that a regular measurement program for this type of contamination should be mandatory under all dismantling processes of transportation and fluid handling equipment for fluids and gases offshore and onshore

  20. Micro-Scale Thermoacoustics

    Science.gov (United States)

    Offner, Avshalom; Ramon, Guy Z.

    2016-11-01

    Thermoacoustic phenomena - conversion of heat to acoustic oscillations - may be harnessed for construction of reliable, practically maintenance-free engines and heat pumps. Specifically, miniaturization of thermoacoustic devices holds great promise for cooling of micro-electronic components. However, as devices size is pushed down to micro-meter scale it is expected that non-negligible slip effects will exist at the solid-fluid interface. Accordingly, new theoretical models for thermoacoustic engines and heat pumps were derived, accounting for a slip boundary condition. These models are essential for the design process of micro-scale thermoacoustic devices that will operate under ultrasonic frequencies. Stability curves for engines - representing the onset of self-sustained oscillations - were calculated with both no-slip and slip boundary conditions, revealing improvement in the performance of engines with slip at the resonance frequency range applicable for micro-scale devices. Maximum achievable temperature differences curves for thermoacoustic heat pumps were calculated, revealing the negative effect of slip on the ability to pump heat up a temperature gradient. The authors acknowledge the support from the Nancy and Stephen Grand Technion Energy Program (GTEP).

  1. H2@Scale Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Mark

    2017-07-12

    'H2@Scale' is a concept based on the opportunity for hydrogen to act as an intermediate between energy sources and uses. Hydrogen has the potential to be used like the primary intermediate in use today, electricity, because it too is fungible. This presentation summarizes the H2@Scale analysis efforts performed during the first third of 2017. Results of technical potential uses and supply options are summarized and show that the technical potential demand for hydrogen is 60 million metric tons per year and that the U.S. has sufficient domestic resources to meet that demand. A high level infrastructure analysis is also presented that shows an 85% increase in energy on the grid if all hydrogen is produced from grid electricity. However, a preliminary spatial assessment shows that supply is sufficient in most counties across the U.S. The presentation also shows plans for analysis of the economic potential for the H2@Scale concept. Those plans involve developing supply and demand curves for potential hydrogen generation options and as compared to other options for use of that hydrogen.

  2. Grading-System-Dependent Volume Effects for Late Radiation-Induced Rectal Toxicity After Curative Radiotherapy for Prostate Cancer

    International Nuclear Information System (INIS)

    Laan, Hans Paul van der; Bergh, Alphons van den; Schilstra, Cornelis; Vlasman, Renske; Meertens, Harm; Langendijk, Johannes A.

    2008-01-01

    Purpose: To assess the association between the dose distributions in the rectum and late Radiation Therapy Oncology Group and the European Organisation for Research and Treatment of Cancer (RTOG/EORTC), Late Effects of Normal Tissue SOMA, and Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 graded rectal toxicity among patients with prostate cancer treated with RT. Methods and Materials: Included in the study were 124 patients who received three-dimensional conformal RT for prostate cancer to a total dose of 70 Gy in 2-Gy fractions. All patients completed questionnaires regarding rectum complaints before RT and during long-term follow-up. Late rectum Grade 2 or worse toxicity, according to RTOG/EORTC, LENT SOMA, and CTCAE v3.0 criteria, was analyzed in relation to rectal dose and volume parameters. Results: Dose-volume thresholds (V40 ≥65%, V50 ≥55%, V65 ≥45%, V70 ≥20%, and a rectum volume ≤140 cm 3 ), significantly discriminated patients with late Grade 0-1 and Grade 2 or worse rectal toxicity, particularly using the LENT SOMA and CTCAE v3.0 systems. The rectum volume receiving ≥70 Gy (V70) was most predictive for late Grade 2 or worse rectal toxicity with each of the grading systems. The associations were strongest, however, with use of the LENT SOMA system. Conclusions: Volume effects for late radiation-induced rectal toxicity are present, but their clinical significance depends on the grading system used. This should be taken into account in the interpretation of studies reporting on radiation-induced rectal toxicity

  3. Neurocognitive function impairment after whole brain radiotherapy for brain metastases: actual assessment

    Directory of Open Access Journals (Sweden)

    Tallet Agnes V

    2012-05-01

    Full Text Available Abstract Whole brain radiation therapy (WBRT is an effective treatment in brain metastases and, when combined with local treatments such as surgery and stereotactic radiosurgery, gives the best brain control. Nonetheless, WBRT is often omitted after local treatment due to its potential late neurocognitive effects. Publications on radiation-induced neurotoxicity have used different assessment methods, time to assessment, and definition of impairment, thus making it difficult to accurately assess the rate and magnitude of the neurocognitive decline that can be expected. In this context, and to help therapeutic decision making, we have conducted this literature review, with the aim of providing an average incidence, magnitude and time to occurrence of radio-induced neurocognitive decline. We reviewed all English language published articles on neurocognitive effects of WBRT for newly diagnosed brain metastases or with a preventive goal in adult patients, with any methodology (MMSE, battery of neurcognitive tests with which baseline status was provided. We concluded that neurocognitive decline is predominant at 4 months, strongly dependant on brain metastases control, partially solved at later time, graded 1 on a SOMA-LENT scale (only 8% of grade 2 and more, insufficiently assessed in long-term survivors, thus justifying all efforts to reduce it through irradiation modulation.

  4. Neurocognitive function impairment after whole brain radiotherapy for brain metastases: actual assessment

    International Nuclear Information System (INIS)

    Tallet, Agnes V; Azria, David; Barlesi, Fabrice; Spano, Jean-Philippe; Carpentier, Antoine F; Gonçalves, Antony; Metellus, Philippe

    2012-01-01

    Whole brain radiation therapy (WBRT) is an effective treatment in brain metastases and, when combined with local treatments such as surgery and stereotactic radiosurgery, gives the best brain control. Nonetheless, WBRT is often omitted after local treatment due to its potential late neurocognitive effects. Publications on radiation-induced neurotoxicity have used different assessment methods, time to assessment, and definition of impairment, thus making it difficult to accurately assess the rate and magnitude of the neurocognitive decline that can be expected. In this context, and to help therapeutic decision making, we have conducted this literature review, with the aim of providing an average incidence, magnitude and time to occurrence of radio-induced neurocognitive decline. We reviewed all English language published articles on neurocognitive effects of WBRT for newly diagnosed brain metastases or with a preventive goal in adult patients, with any methodology (MMSE, battery of neurcognitive tests) with which baseline status was provided. We concluded that neurocognitive decline is predominant at 4 months, strongly dependant on brain metastases control, partially solved at later time, graded 1 on a SOMA-LENT scale (only 8% of grade 2 and more), insufficiently assessed in long-term survivors, thus justifying all efforts to reduce it through irradiation modulation

  5. Pulse dose-rate brachytherapy and treatment of uterine cervix cancer: impact of a 3D or a 2D dosimetric support

    International Nuclear Information System (INIS)

    Tournat, H.; Chilles, A.; Charra-Brunaud, C.; Peiffert, D.; Ahmad, F.; Metayer, Y.

    2007-01-01

    Purpose To evaluate two dosimetric supports used in pulse dose rate brachytherapy (P.D.R.): coverage of target volumes, dose to organs at risk, residual tumor after surgery, survival. Patients and methods Twenty patients treated for uterine cervix tumor first by brachytherapy P.D.R. had a dosimetric CT-scan after implantation. For 9 patients, the treatment was planned from standard radiographies and then reported on CT-scan images. For 11 patients, it was directly planned from CT-scan. Six weeks after, 18 patients underwent surgery. Results With a median follow-up of 22 months, 2 year actuarial survival was 89%. Six patients developed grade II urinary or gynecological complications (LENT SOMA scale). No residual tumor was found for 12 patients (7 with a 3D treatment and 5 a 2 D treatment). Ninety-five percent of C.T.V.H.R. received 53 Gy (2D treatment) or 63 Gy (3D treatment). Two cm 3 of bladder wall received 63 Gy (2D) or 74 Gy (3D) although 2 cm 3 of rectal wall received 37 Gy (2D) and 35 Gy (3D). Conclusion Using CT-scan made us improve the coverage of the uterine cervix but increase the dose received by the bladder, without increasing the rate of histological remission after surgery. We should be prudent before changing our practice. (authors)

  6. Scaling Big Data Cleansing

    KAUST Repository

    Khayyat, Zuhair

    2017-07-31

    Data cleansing approaches have usually focused on detecting and fixing errors with little attention to big data scaling. This presents a serious impediment since identify- ing and repairing dirty data often involves processing huge input datasets, handling sophisticated error discovery approaches and managing huge arbitrary errors. With large datasets, error detection becomes overly expensive and complicated especially when considering user-defined functions. Furthermore, a distinctive algorithm is de- sired to optimize inequality joins in sophisticated error discovery rather than na ̈ıvely parallelizing them. Also, when repairing large errors, their skewed distribution may obstruct effective error repairs. In this dissertation, I present solutions to overcome the above three problems in scaling data cleansing. First, I present BigDansing as a general system to tackle efficiency, scalability, and ease-of-use issues in data cleansing for Big Data. It automatically parallelizes the user’s code on top of general-purpose distributed platforms. Its programming inter- face allows users to express data quality rules independently from the requirements of parallel and distributed environments. Without sacrificing their quality, BigDans- ing also enables parallel execution of serial repair algorithms by exploiting the graph representation of discovered errors. The experimental results show that BigDansing outperforms existing baselines up to more than two orders of magnitude. Although BigDansing scales cleansing jobs, it still lacks the ability to handle sophisticated error discovery requiring inequality joins. Therefore, I developed IEJoin as an algorithm for fast inequality joins. It is based on sorted arrays and space efficient bit-arrays to reduce the problem’s search space. By comparing IEJoin against well- known optimizations, I show that it is more scalable, and several orders of magnitude faster. BigDansing depends on vertex-centric graph systems, i.e., Pregel

  7. Magnetic Scaling in Superconductors

    International Nuclear Information System (INIS)

    Lawrie, I.D.

    1997-01-01

    The Ginzburg-Landau-Wilson superconductor in a magnetic field B is considered in the approximation that magnetic-field fluctuations are neglected. A formulation of perturbation theory is presented in which multiloop calculations fully retaining all Landau levels are tractable. A 2-loop calculation shows that, near the zero-field critical point, the singular part of the free energy scales as F sing ∼ |t| 2-α F(B|t| -2ν ), where ν is the coherence-length exponent emdash a result which has hitherto been assumed on purely dimensional grounds. copyright 1997 The American Physical Society

  8. Scaling CouchDB

    CERN Document Server

    Holt, Bradley

    2011-01-01

    This practical guide offers a short course on scaling CouchDB to meet the capacity needs of your distributed application. Through a series of scenario-based examples, this book lets you explore several methods for creating a system that can accommodate growth and meet expected demand. In the process, you learn about several tools that can help you with replication, load balancing, clustering, and load testing and monitoring. Apply performance tips for tuning your databaseReplicate data, using Futon and CouchDB's RESTful interfaceDistribute CouchDB's workload through load balancingLearn option

  9. Scaling in quantum gravity

    Directory of Open Access Journals (Sweden)

    J. Ambjørn

    1995-07-01

    Full Text Available The 2-point function is the natural object in quantum gravity for extracting critical behavior: The exponential falloff of the 2-point function with geodesic distance determines the fractal dimension dH of space-time. The integral of the 2-point function determines the entropy exponent γ, i.e. the fractal structure related to baby universes, while the short distance behavior of the 2-point function connects γ and dH by a quantum gravity version of Fisher's scaling relation. We verify this behavior in the case of 2d gravity by explicit calculation.

  10. Moment magnitude scale

    Energy Technology Data Exchange (ETDEWEB)

    Hanks, T.C.; Kanamori, H.

    1979-05-10

    The nearly conincident forms of the relations between seismic moment M/sub o/ and the magnitudes M/sub L/, M/sub s/, and M/sub w/ imply a moment magnitude scale M=2/3 log M/sub o/-10.7 which is uniformly valid for 3< or approx. =M/sub L/< or approx. = 7, 5 < or approx. =M/sub s/< or approx. =7 1/2 and M/sub w/> or approx. = 7 1/2.

  11. Scales on the scalp

    Directory of Open Access Journals (Sweden)

    Jamil A

    2013-05-01

    Full Text Available A five-year-old boy presented with a six-week history of scales, flaking and crusting of the scalp. He had mild pruritus but no pain. He did not have a history of atopy and there were no pets at home. Examination of the scalp showed thick, yellowish dry crusts on the vertex and parietal areas and the hair was adhered to the scalp in clumps. There was non-scarring alopecia and mild erythema (Figure 1 & 2. There was no cervical or occipital lymphadenopathy. The patient’s nails and skin in other parts of the body were normal.

  12. A problem of scale

    International Nuclear Information System (INIS)

    Harrison, L.

    1991-01-01

    Small scale wind energy conversion is finding it even more difficult to realise its huge potential market than grid connected wind power. One of the main reasons for this is that its technical development is carried out in isolated parts of the world with little opportunity for technology transfer: small scale wind energy converters (SWECS) are not born of one technology, but have been evolved for different purposes; as a result, the SWECS community has no powerful lobbying force speaking with one voice to promote the technology. There are three distinct areas of application for SWECS, water pumping for domestic and livestock water supplies, irrigation, drainage etc., where no other mechanical means of power is available or viable, battery charging for lighting, TV, radio, and telecommunications in areas far from a grid or road system, and wind-diesel systems, mainly for use on islands where supply of diesel oil is possible, but costly. An attempt is being made to found an association to support the widespread implementation of SWECS and to promote their implementation. It is intended for Wind Energy for Rural Areas to have a permanent secretariat, based in Holland. (AB)

  13. The Unintentional Procrastination Scale.

    Science.gov (United States)

    Fernie, Bruce A; Bharucha, Zinnia; Nikčević, Ana V; Spada, Marcantonio M

    2017-01-01

    Procrastination refers to the delay or postponement of a task or decision and is often conceptualised as a failure of self-regulation. Recent research has suggested that procrastination could be delineated into two domains: intentional and unintentional. In this two-study paper, we aimed to develop a measure of unintentional procrastination (named the Unintentional Procrastination Scale or the 'UPS') and test whether this would be a stronger marker of psychopathology than intentional and general procrastination. In Study 1, a community sample of 139 participants completed a questionnaire that consisted of several items pertaining to unintentional procrastination that had been derived from theory, previous research, and clinical experience. Responses were subjected to a principle components analysis and assessment of internal consistency. In Study 2, a community sample of 155 participants completed the newly developed scale, along with measures of general and intentional procrastination, metacognitions about procrastination, and negative affect. Data from the UPS were subjected to confirmatory factor analysis and revised accordingly. The UPS was then validated using correlation and regression analyses. The six-item UPS possesses construct and divergent validity and good internal consistency. The UPS appears to be a stronger marker of psychopathology than the pre-existing measures of procrastination used in this study. Results from the regression models suggest that both negative affect and metacognitions about procrastination differentiate between general, intentional, and unintentional procrastination. The UPS is brief, has good psychometric properties, and has strong associations with negative affect, suggesting it has value as a research and clinical tool.

  14. Scaling MongoDB

    CERN Document Server

    Chodorow, Kristina

    2011-01-01

    Create a MongoDB cluster that will to grow to meet the needs of your application. With this short and concise book, you'll get guidelines for setting up and using clusters to store a large volume of data, and learn how to access the data efficiently. In the process, you'll understand how to make your application work with a distributed database system. Scaling MongoDB will help you: Set up a MongoDB cluster through shardingWork with a cluster to query and update dataOperate, monitor, and backup your clusterPlan your application to deal with outages By following the advice in this book, you'l

  15. Large Scale Solar Heating

    DEFF Research Database (Denmark)

    Heller, Alfred

    2001-01-01

    The main objective of the research was to evaluate large-scale solar heating connected to district heating (CSDHP), to build up a simulation tool and to demonstrate the application of the simulation tool for design studies and on a local energy planning case. The evaluation was mainly carried out...... model is designed and validated on the Marstal case. Applying the Danish Reference Year, a design tool is presented. The simulation tool is used for proposals for application of alternative designs, including high-performance solar collector types (trough solar collectors, vaccum pipe collectors......). Simulation programs are proposed as control supporting tool for daily operation and performance prediction of central solar heating plants. Finaly the CSHP technolgy is put into persepctive with respect to alternatives and a short discussion on the barries and breakthrough of the technology are given....

  16. On Scale and Fields

    DEFF Research Database (Denmark)

    Kadish, David

    2017-01-01

    This paper explores thematic parallels between artistic and agricultural practices in the postwar period to establish a link to media art and cultural practices that are currently emerging in urban agriculture. Industrial agriculture has roots in the post-WWII abundance of mechanical and chemical...... equipment and research. These systems are highly mechanically efficient. With minimal physical labour, they extract ever staggering crop yields from ever poorer soils in shifting climatic conditions. However, the fact of mechanical efficiency is used to mask a set of problems with industrial......-scale agricultural systems that range from spreading pests and diseases to poor global distribution of concentrated regional food wealth. That the conversion of vegetatively diverse farmland into monochromatic fields was popularized at the same time as the arrival of colour field paintings like Barnett Newman...

  17. ScaleUp America Communities

    Data.gov (United States)

    Small Business Administration — SBA’s new ScaleUp America Initiative is designed to help small firms with high potential “scale up” and grow their businesses so that they will provide more jobs and...

  18. MULTIPLE SCALES FOR SUSTAINABLE RESULTS

    Science.gov (United States)

    This session will highlight recent research that incorporates the use of multiple scales and innovative environmental accounting to better inform decisions that affect sustainability, resilience, and vulnerability at all scales. Effective decision-making involves assessment at mu...

  19. Absolute flux scale for radioastronomy

    International Nuclear Information System (INIS)

    Ivanov, V.P.; Stankevich, K.S.

    1986-01-01

    The authors propose and provide support for a new absolute flux scale for radio astronomy, which is not encumbered with the inadequacies of the previous scales. In constructing it the method of relative spectra was used (a powerful tool for choosing reference spectra). A review is given of previous flux scales. The authors compare the AIS scale with the scale they propose. Both scales are based on absolute measurements by the ''artificial moon'' method, and they are practically coincident in the range from 0.96 to 6 GHz. At frequencies above 6 GHz, 0.96 GHz, the AIS scale is overestimated because of incorrect extrapolation of the spectra of the primary and secondary standards. The major results which have emerged from this review of absolute scales in radio astronomy are summarized

  20. Northeast Snowfall Impact Scale (NESIS)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — While the Fujita and Saffir-Simpson Scales characterize tornadoes and hurricanes respectively, there is no widely used scale to classify snowstorms. The Northeast...

  1. Scale setting in lattice QCD

    International Nuclear Information System (INIS)

    Sommer, Rainer

    2014-02-01

    The principles of scale setting in lattice QCD as well as the advantages and disadvantages of various commonly used scales are discussed. After listing criteria for good scales, I concentrate on the main presently used ones with an emphasis on scales derived from the Yang-Mills gradient flow. For these I discuss discretisation errors, statistical precision and mass effects. A short review on numerical results also brings me to an unpleasant disagreement which remains to be explained.

  2. NoSQL database scaling

    OpenAIRE

    Žardin, Norbert

    2017-01-01

    NoSQL database scaling is a decision, where system resources or financial expenses are traded for database performance or other benefits. By scaling a database, database performance and resource usage might increase or decrease, such changes might have a negative impact on an application that uses the database. In this work it is analyzed how database scaling affect database resource usage and performance. As a results, calculations are acquired, using which database scaling types and differe...

  3. Scale setting in lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Sommer, Rainer [DESY, Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC

    2014-02-15

    The principles of scale setting in lattice QCD as well as the advantages and disadvantages of various commonly used scales are discussed. After listing criteria for good scales, I concentrate on the main presently used ones with an emphasis on scales derived from the Yang-Mills gradient flow. For these I discuss discretisation errors, statistical precision and mass effects. A short review on numerical results also brings me to an unpleasant disagreement which remains to be explained.

  4. Scale issues in tourism development

    Science.gov (United States)

    Sinji Yang; Lori Pennington-Gray; Donald F. Holecek

    1998-01-01

    Proponents of Alternative Tourism overwhelmingly believe that alternative forms of tourism development need to be small in scale. Inasmuch as tourists' demand has great power to shape the market, the issues surrounding the tourism development scale deserve further consideration. This paper discusses the implications and effects of the tourism development scale on...

  5. Scaling up: Assessing social impacts at the macro-scale

    International Nuclear Information System (INIS)

    Schirmer, Jacki

    2011-01-01

    Social impacts occur at various scales, from the micro-scale of the individual to the macro-scale of the community. Identifying the macro-scale social changes that results from an impacting event is a common goal of social impact assessment (SIA), but is challenging as multiple factors simultaneously influence social trends at any given time, and there are usually only a small number of cases available for examination. While some methods have been proposed for establishing the contribution of an impacting event to macro-scale social change, they remain relatively untested. This paper critically reviews methods recommended to assess macro-scale social impacts, and proposes and demonstrates a new approach. The 'scaling up' method involves developing a chain of logic linking change at the individual/site scale to the community scale. It enables a more problematised assessment of the likely contribution of an impacting event to macro-scale social change than previous approaches. The use of this approach in a recent study of change in dairy farming in south east Australia is described.

  6. Scaling of structural failure

    Energy Technology Data Exchange (ETDEWEB)

    Bazant, Z.P. [Northwestern Univ., Evanston, IL (United States); Chen, Er-Ping [Sandia National Lab., Albuquerque, NM (United States)

    1997-01-01

    This article attempts to review the progress achieved in the understanding of scaling and size effect in the failure of structures. Particular emphasis is placed on quasibrittle materials for which the size effect is complicated. Attention is focused on three main types of size effects, namely the statistical size effect due to randomness of strength, the energy release size effect, and the possible size effect due to fractality of fracture or microcracks. Definitive conclusions on the applicability of these theories are drawn. Subsequently, the article discusses the application of the known size effect law for the measurement of material fracture properties, and the modeling of the size effect by the cohesive crack model, nonlocal finite element models and discrete element models. Extensions to compression failure and to the rate-dependent material behavior are also outlined. The damage constitutive law needed for describing a microcracked material in the fracture process zone is discussed. Various applications to quasibrittle materials, including concrete, sea ice, fiber composites, rocks and ceramics are presented.

  7. SPACE BASED INTERCEPTOR SCALING

    Energy Technology Data Exchange (ETDEWEB)

    G. CANAVAN

    2001-02-01

    Space Based Interceptor (SBI) have ranges that are adequate to address rogue ICBMs. They are not overly sensitive to 30-60 s delay times. Current technologies would support boost phase intercept with about 150 interceptors. Higher acceleration and velocity could reduce than number by about a factor of 3 at the cost of heavier and more expensive Kinetic Kill Vehicles (KKVs). 6g SBI would reduce optimal constellation costs by about 35%; 8g SBI would reduce them another 20%. Interceptor ranges fall rapidly with theater missile range. Constellations increase significantly for ranges under 3,000 km, even with advanced interceptor technology. For distributed launches, these estimates recover earlier strategic scalings, which demonstrate the improved absentee ratio for larger or multiple launch areas. Constellations increase with the number of missiles and the number of interceptors launched at each. The economic estimates above suggest that two SBI per missile with a modest midcourse underlay is appropriate. The SBI KKV technology would appear to be common for space- and surface-based boost phase systems, and could have synergisms with improved midcourse intercept and discrimination systems. While advanced technology could be helpful in reducing costs, particularly for short range theater missiles, current technology appears adequate for pressing rogue ICBM, accidental, and unauthorized launches.

  8. Large scale tracking algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Ross L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Love, Joshua Alan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Melgaard, David Kennett [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Karelitz, David B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pitts, Todd Alan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Zollweg, Joshua David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Anderson, Dylan Z. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nandy, Prabal [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Whitlow, Gary L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bender, Daniel A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Byrne, Raymond Harry [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-01-01

    Low signal-to-noise data processing algorithms for improved detection, tracking, discrimination and situational threat assessment are a key research challenge. As sensor technologies progress, the number of pixels will increase signi cantly. This will result in increased resolution, which could improve object discrimination, but unfortunately, will also result in a significant increase in the number of potential targets to track. Many tracking techniques, like multi-hypothesis trackers, suffer from a combinatorial explosion as the number of potential targets increase. As the resolution increases, the phenomenology applied towards detection algorithms also changes. For low resolution sensors, "blob" tracking is the norm. For higher resolution data, additional information may be employed in the detection and classfication steps. The most challenging scenarios are those where the targets cannot be fully resolved, yet must be tracked and distinguished for neighboring closely spaced objects. Tracking vehicles in an urban environment is an example of such a challenging scenario. This report evaluates several potential tracking algorithms for large-scale tracking in an urban environment.

  9. Tipping the scales.

    Science.gov (United States)

    1998-12-01

    In the US, the October 1998 murder of a physician who performed abortions was an outward manifestation of the insidious battle against legal abortion being waged by radical Christian social conservatives seeking to transform the US democracy into a theocracy. This movement has been documented in a publication entitled, "Tipping the Scales: The Christian Right's Legal Crusade Against Choice" produced as a result of a 4-year investigation conducted by The Center for Reproductive Law and Policy. This publication describes how these fundamentalists have used sophisticated legal, lobbying, and communication strategies to further their goals of challenging the separation of church and state, opposing family planning and sexuality education that is not based solely on abstinence, promoting school prayer, and restricting homosexual rights. The movement has resulted in the introduction of more than 300 anti-abortion bills in states, 50 of which have passed in 23 states. Most Christian fundamentalist groups provide free legal representation to abortion clinic terrorists, and some groups solicit women to bring specious malpractice claims against providers. Sophisticated legal tactics are used by these groups to remove the taint of extremism and mask the danger posed to US constitutional principles being posed by "a well-financed and zealous brand of radical lawyers and their supporters."

  10. The Bereavement Guilt Scale.

    Science.gov (United States)

    Li, Jie; Stroebe, Magaret; Chan, Cecilia L W; Chow, Amy Y M

    2017-06-01

    The rationale, development, and validation of the Bereavement Guilt Scale (BGS) are described in this article. The BGS was based on a theoretically developed, multidimensional conceptualization of guilt. Part 1 describes the generation of the item pool, derived from in-depth interviews, and review of the scientific literature. Part 2 details statistical analyses for further item selection (Sample 1, N = 273). Part 3 covers the psychometric properties of the emergent-BGS (Sample 2, N = 600, and Sample 3, N = 479). Confirmatory factor analysis indicated that a five-factor model fit the data best. Correlations of BGS scores with depression, anxiety, self-esteem, self-forgiveness, and mode of death were consistent with theoretical predictions, supporting the construct validity of the measure. The internal consistency and test-retest reliability were also supported. Thus, initial testing or examination suggests that the BGS is a valid tool to assess multiple components of bereavement guilt. Further psychometric testing across cultures is recommended.

  11. A multi scale model for small scale plasticity

    International Nuclear Information System (INIS)

    Zbib, Hussein M.

    2002-01-01

    Full text.A framework for investigating size-dependent small-scale plasticity phenomena and related material instabilities at various length scales ranging from the nano-microscale to the mesoscale is presented. The model is based on fundamental physical laws that govern dislocation motion and their interaction with various defects and interfaces. Particularly, a multi-scale model is developed merging two scales, the nano-microscale where plasticity is determined by explicit three-dimensional dislocation dynamics analysis providing the material length-scale, and the continuum scale where energy transport is based on basic continuum mechanics laws. The result is a hybrid simulation model coupling discrete dislocation dynamics with finite element analyses. With this hybrid approach, one can address complex size-dependent problems, including dislocation boundaries, dislocations in heterogeneous structures, dislocation interaction with interfaces and associated shape changes and lattice rotations, as well as deformation in nano-structured materials, localized deformation and shear band

  12. Minimum Efficient Scale (MES) and preferred scale of container terminals

    OpenAIRE

    Kaselimi, Evangelia N.; Notteboom, Theo E.; Pallis, Athanasios A.; Farrell, Sheila

    2011-01-01

    Abstract: The decision on the scale of a port terminal affects the terminals managerial, operational and competitive position in all the phases of its life. It also affects competition structures in the port in which the terminal is operating, and has a potential impact on other terminals. Port authorities and terminal operators need to know the scale of the terminal when engaging in concession agreements. In economic theory the scale of a plant/firm is typically defined in relation to the Mi...

  13. The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization.

    Science.gov (United States)

    Laperchia, Claudia; Imperatore, Roberta; Azeez, Idris A; Del Gallo, Federico; Bertini, Giuseppe; Grassi-Zucconi, Gigliola; Cristino, Luigia; Bentivoglio, Marina

    2017-11-01

    Orexin (OX)/hypocretin-containing neurons are main regulators of wakefulness stability, arousal, and energy homeostasis. Their activity varies in relation to the animal's behavioral state. We here tested whether such variation is subserved by synaptic plasticity phenomena in basal conditions. Mice were sacrificed during day or night, at times when sleep or wake, respectively, predominates, as assessed by electroencephalography in matched mice. Triple immunofluorescence was used to visualize OX-A perikarya and varicosities containing the vesicular glutamate transporter (VGluT)2 or the vesicular GABA transporter (VGAT) combined with synaptophysin (Syn) as a presynaptic marker. Appositions on OX-A + somata were quantitatively analyzed in pairs of sections in epifluorescence and confocal microscopy. The combined total number of glutamatergic (Syn + /VGluT2 + ) and GABAergic (Syn + /VGAT + ) varicosities apposed to OX-A somata was similar during day and night. However, glutamatergic varicosities were significantly more numerous at night, whereas GABAergic varicosities prevailed in the day. Triple immunofluorescence in confocal microscopy was employed to visualize synapse scaffold proteins as postsynaptic markers and confirmed the nighttime prevalence of VGluT2 + together with postsynaptic density protein 95 + excitatory contacts, and daytime prevalence of VGAT + together with gephyrin + inhibitory contacts, while also showing that they formed synapses on OX-A + cell bodies. The findings reveal a daily reorganization of axosomatic synapses in orexinergic neurons, with a switch from a prevalence of excitatory innervation at a time corresponding to wakefulness to a prevalence of inhibitory innervations in the antiphase, at a time corresponding to sleep. This reorganization could represent a key mechanism of plasticity of the orexinergic network in basal conditions.

  14. Hypothyroidism in the rat results in decreased soleus motoneurone soma size

    NARCIS (Netherlands)

    Bakels, R; Nijenhuis, Albertine; Mast, L; Kernell, D

    1998-01-01

    Adult female rats were thyroidectomized. After an average of 17 weeks, horseradish peroxidase (HRP) was injected into the right side soleus muscle. Two days later, left side soleus muscle properties were recorded and muscles and spinal cord were removed for further histological measurements. Soleus

  15. Allergic to people: building bridges in a ripped psychic-soma.

    Science.gov (United States)

    Teitelbaum, Stefanie

    2008-06-01

    An exploration of the use mind/body metaphors in a woman whose physical, environmental and psychoneurotic trauma culminated in an irreversible colostomy. She lived in a world of concrete symbols, her primary process damaged such that she could not create generative symbols to process her trauma. She regressed to a state of infantile megalomania, recoiling from the external reality of subjective others. Her introjective disorder mirrored her digestive disorder as she could absorb neither good objects nor good nutrients. The analytic situation has been an auxiliary fecal container and we work to bridge her mind body split with mind/body metaphors. As she reclaims lost development mastery, she displays a symbolized sphincter. As her capacity to form symbols grows, she rages and mourns for the loss of her fantasized ideal parents and her ideal body.

  16. Interaction between the soma and the axon terminal of horizontal cells in carp retina

    NARCIS (Netherlands)

    Kamermans, M.; van Dijk, B. W.; Spekreijse, H.

    1990-01-01

    In teleost retina, the receptive fields of horizontal cell axon terminals have a larger space constant than the receptive fields of the horizontal cell somata. Generally this difference in receptive field size is attributed to the cell coupling which is assumed to be stronger in the horizontal axon

  17. Sexually Antagonistic Male Signals Manipulate Germline and Soma of C. elegans Hermaphrodites.

    Science.gov (United States)

    Aprison, Erin Z; Ruvinsky, Ilya

    2016-10-24

    Males and females pursue different reproductive strategies, which often bring them into conflict-many traits exist that benefit one sex at a cost to another [1]. Decreased female survival following mating dramatically demonstrates one aspect of this phenomenon [2-5]. Particularly intriguing is the evidence that secreted compounds can shorten lifespan of members of the opposite sex in Drosophila [6] and Caenorhabditid nematodes [7] even without copulation taking place. The purpose of such signals is not clear, however. While it is possible that they could limit subsequent mating with competitors or hasten post-reproductive demise, thus decreasing competition for resources, they are also likely to harm unmated individuals. Why would a system exist that reduces the vigor of potential mates prior to mating? Addressing this question could provide insights into mechanisms and evolution of sexual conflict and reveal sensory inputs that regulate aging. Here, we describe two distinct ways in which Caenorhabditis elegans males cause faster somatic aging of hermaphrodites but also manipulate different aspects of their reproductive physiology. The first, mediated by conserved ascaroside pheromones, delays the loss of germline progenitor cells. The second accelerates development, resulting in faster sexual maturation. These signals promote male reproductive strategy and the effects harmful to hermaphrodites appear to be collateral damage rather than the goal. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Psyche, soma, and science studies: new directions in the sociology of mental health and illness.

    Science.gov (United States)

    Pickersgill, Martyn D

    2010-08-01

    With the expanding scope of scientific and technological discourse within psychiatry, social scientists need new theoretical tools to grapple with the complex links between psychiatry, science and society. Benefit may be afforded through engagement with the discipline of science and technology studies (STS), which is concerned explicitly with the relationships between science and society. To highlight existing engagements between STS and the sociology of (mental) health, and to encourage researchers to consider ways in which insights from these traditions may be developed further through interdisciplinary debate and analysis. Some of the key works in STS and the sociology of mental illness that use the empirical or theoretical writings of the other were reviewed and appraised. Whilst it is clear that some research synthesizing insights from STS and the sociology of mental health exists, this is currently limited. Sociologists and others concerned with longstanding and emergent issues in mental health might usefully familiarize themselves with some work in STS. A new sociology of psychiatric knowledge production and application represents an important way forward.

  19. [Psyche and soma: what can the consultation-liaison psychiatrist contribute?].

    Science.gov (United States)

    Diefenbacher, Albert

    2015-01-01

    In German speaking countries, during the last decades, we can see a growing, though albeit small, integration of psychiatry and psychosomatics into (somatic) medicine. This article outlines the importance of the growing number of elderly patients in medical care as a vantage point for c-l-psychiatrists to play a pro-active role in implementing adequate structures and processes for diagnostics and treatment of this patient group. It is argued that delirium (in dementia) can and should be regarded as a paradigm for a biopsychosocial disorder sui generis. In addition, aspects of the cl-psychiatrists role at two important interfaces of somatic and psychological medicine, i.e. primary care and emergency rooms, are highlighted. Finally, some information about the development of the professionalization of cl-psychiatry in Europe is given.

  20. Drawing together psyche, soma and spirit: my career in cultural psychiatry.

    Science.gov (United States)

    Dein, Simon

    2011-04-01

    In this article I discuss my career in cultural psychiatry. I begin by examining the influence of my personal background on my interests in cultural psychiatry and religion and health. I then discuss my research, which has focused upon two areas: the cognitive and phenomenological parallels between religious experiences and psychopathological states, and relationships between biomedicine and religious healing in diverse cultural contexts. Finally, I discuss plans for future research and teaching.

  1. The History of Mind (Psyche)-Body (Soma) Medicine: Practical Examples.

    Science.gov (United States)

    Martins, Paulo Nuno

    2018-01-01

    This article discusses the relationship between health and disease, considering the mind/body dichotomy that has occurred in the history of medicine, both in Western and Eastern cultures. The author begins by referring to the magical concept of disease, passing through the classical Greek period, and the medieval and Renaissance vision, to the evolution of modern concepts proposed by psychoanalysis. The author references some practical examples about the importance of the mind-body relationship, such as the psychological steps experienced by the oncological patient, as well as the psychiatric disorder.

  2. [Fifty years of psychiatry at the interface between psyche and soma: a SWOT analysis].

    Science.gov (United States)

    van Houdenhove, B; Luyten, P

    2008-01-01

    During the past 50 years the border area between psychiatry and somatic medicine has undergone remarkable changes. Theories have become better-founded, both psychologically and neurobiologically, research has become more sophisticated, and liaison-psychiatrists and health psychiatrist/behavioural medicine psychologists have played an increasingly active role in this domain. At the beginning of the 21st century modern psychosomatic medicine is facing new challenges; these include how to create a workable diagnostic classification system, how to instruct and educate both health professionals and lay-persons to an adequate level, how to utilize innovative research paradigms without having recourse to reductionism and how to implement in medical practice treatments that are geared to the needs of the individual patient.

  3. VizieR Online Data Catalog: SOFIA Massive (SOMA) Star Formation Survey. I. (De Buizer+, 2017)

    Science.gov (United States)

    De Buizer, J. M.; Liu, M.; Tan, J. C.; Zhang, Y.; Beltran, M. T.; Shuping, R.; Staff, J. E.; Tanaka, K. E. I.; Whitney, B.

    2018-02-01

    The following eight sources, AFGL 4029, AFGL 437, IRAS 07299-1651, G35.20-0.74, G45.45+0.05, IRAS 20126+4104, Cepheus A, and NGC 7538 IRS9, were observed by SOFIA with the FORCAST instrument (see Table 1). Data were taken on multiple flights spanning the Early Science period, Cycle 1, and Cycle 2 SOFIA observing cycles (spanning 2011 May to 2014 June). (4 data files).

  4. Barriers to obstetric care among maternal near-misses | Soma-Pillay ...

    African Journals Online (AJOL)

    One hundred maternal near-misses were prospectively identified using the World Health Organization criteria. ... The above causes were also the most important factors causing delays for the leading causes of maternal near-misses – obstetric haemorrhage, hypertension/pre-eclampsia, and medical and surgical conditions.

  5. Memory, reconsolidation and extinction in Lymnaea require the soma of RPeD1.

    Science.gov (United States)

    Sangha, Susan; Varshney, Nishi; Fras, Mary; Smyth, Kim; Rosenegger, David; Parvez, Kashif; Sadamoto, Hisayo; Lukowiak, Ken

    2004-01-01

    The central pattern generator (CPG) that drives aerial respiratory behaviour in Lymnaea consists of 3 neurons. One of these, RPeD1--the cell that initiates activity in the circuit, plays an absolutely necessary role as a site for memory formation, memory reconsolidation, and extinction. Using an operant conditioning training procedure that results in a long-term non-declarative memory (LTM), we decrease the occurrence of aerial respiratory behaviour. Since snails can still breathe cutaneously learning this procedure is not harmful. Concomitant with behavioural memory are changes in the spiking activity of RPeD1. Going beyond neural correlates of memory we directly show that RPeD1 is a necessary site for LTM formation. Expanding on this finding we show that this neuron is also a necessary site for memory reconsolidation and 'Pavlovian' extinction. As far as we can determine, this is the first time a single neuron has been shown to be a necessary site for these different aspects memory. RPeD1 is thus a key neuron mediating different hierarchical aspects of memory. We are now in a position to determine the necessary neuronal, molecular and proteomic events in this neuron that are causal to memory formation, reconsolidation and extinction.

  6. SOMA A Tool for Synthesizing and Optimizing Memory Accesses in ASICs

    DEFF Research Database (Denmark)

    Venkataramani, Girish; Bjerregaard, Tobias; Chelcea, Tiberiu

    2005-01-01

    parallelism profile of the application. This is then used to customize the MAN architecture. Depending on the parallelism profile, the MAN may be optimized for latency, throughput or both. The optimized MAN is automatically synthesized into gate-level structural Verilog using a flexible library of network...

  7. The Scales of Injustice

    Directory of Open Access Journals (Sweden)

    Charles Blattberg

    2008-02-01

    Full Text Available This paper criticises four major approaches to criminal law – consequentialism, retributivism, abolitionism, and “mixed” pluralism – each of which, in its own fashion, affirms the celebrated emblem of the “scales of justice.” The argument is that there is a better way of dealing with the tensions that often arise between the various legal purposes than by merely balancing them against each other. It consists, essentially, of striving to genuinely reconcile those purposes, a goal which is shown to require taking a new, “patriotic” approach to law. Le présent article porte une critique à quatre approches majeures en droit pénal : le conséquentialisme, le rétributivisme, l’abolitionnisme et le pluralisme « mixte. » Toutes ces approches se rangent, chacune à leur manière, sous le célèbre emblème des « échelles de justice. » L’argument est qu’il existe une meilleure façon de faire face aux tensions qui opposent les multiples objectifs judiciaires plutôt que de comparer le poids des uns contre le poids des autres. Il s’agit essentiellement de s’efforcer à réaliser une authentique réconciliation de ces objectifs. Il apparaîtra que pour y parvenir il est nécessaire d’avoir recours à une nouvelle approche du droit, une approche précisément « patriotique. »

  8. Industrial scale gene synthesis.

    Science.gov (United States)

    Notka, Frank; Liss, Michael; Wagner, Ralf

    2011-01-01

    The most recent developments in the area of deep DNA sequencing and downstream quantitative and functional analysis are rapidly adding a new dimension to understanding biochemical pathways and metabolic interdependencies. These increasing insights pave the way to designing new strategies that address public needs, including environmental applications and therapeutic inventions, or novel cell factories for sustainable and reconcilable energy or chemicals sources. Adding yet another level is building upon nonnaturally occurring networks and pathways. Recent developments in synthetic biology have created economic and reliable options for designing and synthesizing genes, operons, and eventually complete genomes. Meanwhile, high-throughput design and synthesis of extremely comprehensive DNA sequences have evolved into an enabling technology already indispensable in various life science sectors today. Here, we describe the industrial perspective of modern gene synthesis and its relationship with synthetic biology. Gene synthesis contributed significantly to the emergence of synthetic biology by not only providing the genetic material in high quality and quantity but also enabling its assembly, according to engineering design principles, in a standardized format. Synthetic biology on the other hand, added the need for assembling complex circuits and large complexes, thus fostering the development of appropriate methods and expanding the scope of applications. Synthetic biology has also stimulated interdisciplinary collaboration as well as integration of the broader public by addressing socioeconomic, philosophical, ethical, political, and legal opportunities and concerns. The demand-driven technological achievements of gene synthesis and the implemented processes are exemplified by an industrial setting of large-scale gene synthesis, describing production from order to delivery. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. Scaling Effects on Materials Tribology: From Macro to Micro Scale.

    Science.gov (United States)

    Stoyanov, Pantcho; Chromik, Richard R

    2017-05-18

    The tribological study of materials inherently involves the interaction of surface asperities at the micro to nanoscopic length scales. This is the case for large scale engineering applications with sliding contacts, where the real area of contact is made up of small contacting asperities that make up only a fraction of the apparent area of contact. This is why researchers have sought to create idealized experiments of single asperity contacts in the field of nanotribology. At the same time, small scale engineering structures known as micro- and nano-electromechanical systems (MEMS and NEMS) have been developed, where the apparent area of contact approaches the length scale of the asperities, meaning the real area of contact for these devices may be only a few asperities. This is essentially the field of microtribology, where the contact size and/or forces involved have pushed the nature of the interaction between two surfaces towards the regime where the scale of the interaction approaches that of the natural length scale of the features on the surface. This paper provides a review of microtribology with the purpose to understand how tribological processes are different at the smaller length scales compared to macrotribology. Studies of the interfacial phenomena at the macroscopic length scales (e.g., using in situ tribometry) will be discussed and correlated with new findings and methodologies at the micro-length scale.

  10. Dynamic critical behaviour and scaling

    International Nuclear Information System (INIS)

    Oezoguz, B.E.

    2001-01-01

    Traditionally the scaling is the property of dynamical systems at thermal equilibrium. In second order phase transitions scaling behaviour is due to the infinite correlation length around the critical point. In first order phase transitions however, the correlation length remains finite and a different type of scaling can be observed. For first order phase transitions all singularities are governed by the volume of the system. Recently, a different type of scaling, namely dynamic scaling has attracted attention in second order phase transitions. In dynamic scaling, when a system prepared at high temperature is quenched to the critical temperature, it exhibits scaling behaviour. Dynamic scaling has been applied to various spin systems and the validity of the arguments are shown. Firstly, in this thesis project the dynamic scaling is applied to 4-dimensional using spin system which exhibits second order phase transition with mean-field critical indices. Secondly, it is shown that although the dynamic is quite different, first order phase transitions also has a different type of dynamic scaling

  11. Plague and Climate: Scales Matter

    Science.gov (United States)

    Ben Ari, Tamara; Neerinckx, Simon; Gage, Kenneth L.; Kreppel, Katharina; Laudisoit, Anne; Leirs, Herwig; Stenseth, Nils Chr.

    2011-01-01

    Plague is enzootic in wildlife populations of small mammals in central and eastern Asia, Africa, South and North America, and has been recognized recently as a reemerging threat to humans. Its causative agent Yersinia pestis relies on wild rodent hosts and flea vectors for its maintenance in nature. Climate influences all three components (i.e., bacteria, vectors, and hosts) of the plague system and is a likely factor to explain some of plague's variability from small and regional to large scales. Here, we review effects of climate variables on plague hosts and vectors from individual or population scales to studies on the whole plague system at a large scale. Upscaled versions of small-scale processes are often invoked to explain plague variability in time and space at larger scales, presumably because similar scale-independent mechanisms underlie these relationships. This linearity assumption is discussed in the light of recent research that suggests some of its limitations. PMID:21949648

  12. H2@Scale Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Pivovar, Bryan

    2017-03-31

    Final report from the H2@Scale Workshop held November 16-17, 2016, at the National Renewable Energy Laboratory in Golden, Colorado. The U.S. Department of Energy's National Renewable Energy Laboratory hosted a technology workshop to identify the current barriers and research needs of the H2@Scale concept. H2@Scale is a concept regarding the potential for wide-scale impact of hydrogen produced from diverse domestic resources to enhance U.S. energy security and enable growth of innovative technologies and domestic industries. Feedback received from a diverse set of stakeholders at the workshop will guide the development of an H2@Scale roadmap for research, development, and early stage demonstration activities that can enable hydrogen as an energy carrier at a national scale.

  13. Scaling structure loads for SMA

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Won; Song, Jeong Guk; Jeon, Sang Ho; Lim, Hak Kyu; Lee, Kwang Nam [KEPCO ENC, Yongin (Korea, Republic of)

    2012-10-15

    When the Seismic Margin Analysis(SMA) is conducted, the new structural load generation with Seismic Margin Earthquake(SME) is the time consuming work. For the convenience, EPRI NP 6041 suggests the scaling of the structure load. The report recommend that the fixed base(rock foundation) structure designed using either constant modal damping or modal damping ratios developed for a single material damping. For these cases, the SME loads can easily and accurately be calculated by scaling the spectral accelerations of the individual modes for the new SME response spectra. EPRI NP 6041 provides two simple methodologies for the scaling structure seismic loads which are the dominant frequency scaling methodology and the mode by mode scaling methodology. Scaling of the existing analysis to develop SME loads is much easier and more efficient than performing a new analysis. This paper is intended to compare the calculating results of two different methodologies.

  14. Scaling structure loads for SMA

    International Nuclear Information System (INIS)

    Lee, Dong Won; Song, Jeong Guk; Jeon, Sang Ho; Lim, Hak Kyu; Lee, Kwang Nam

    2012-01-01

    When the Seismic Margin Analysis(SMA) is conducted, the new structural load generation with Seismic Margin Earthquake(SME) is the time consuming work. For the convenience, EPRI NP 6041 suggests the scaling of the structure load. The report recommend that the fixed base(rock foundation) structure designed using either constant modal damping or modal damping ratios developed for a single material damping. For these cases, the SME loads can easily and accurately be calculated by scaling the spectral accelerations of the individual modes for the new SME response spectra. EPRI NP 6041 provides two simple methodologies for the scaling structure seismic loads which are the dominant frequency scaling methodology and the mode by mode scaling methodology. Scaling of the existing analysis to develop SME loads is much easier and more efficient than performing a new analysis. This paper is intended to compare the calculating results of two different methodologies

  15. International Symposia on Scale Modeling

    CERN Document Server

    Ito, Akihiko; Nakamura, Yuji; Kuwana, Kazunori

    2015-01-01

    This volume thoroughly covers scale modeling and serves as the definitive source of information on scale modeling as a powerful simplifying and clarifying tool used by scientists and engineers across many disciplines. The book elucidates techniques used when it would be too expensive, or too difficult, to test a system of interest in the field. Topics addressed in the current edition include scale modeling to study weather systems, diffusion of pollution in air or water, chemical process in 3-D turbulent flow, multiphase combustion, flame propagation, biological systems, behavior of materials at nano- and micro-scales, and many more. This is an ideal book for students, both graduate and undergraduate, as well as engineers and scientists interested in the latest developments in scale modeling. This book also: Enables readers to evaluate essential and salient aspects of profoundly complex systems, mechanisms, and phenomena at scale Offers engineers and designers a new point of view, liberating creative and inno...

  16. Contact kinematics of biomimetic scales

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, Ranajay; Ebrahimi, Hamid; Vaziri, Ashkan, E-mail: vaziri@coe.neu.edu [Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02115 (United States)

    2014-12-08

    Dermal scales, prevalent across biological groups, considerably boost survival by providing multifunctional advantages. Here, we investigate the nonlinear mechanical effects of biomimetic scale like attachments on the behavior of an elastic substrate brought about by the contact interaction of scales in pure bending using qualitative experiments, analytical models, and detailed finite element (FE) analysis. Our results reveal the existence of three distinct kinematic phases of operation spanning linear, nonlinear, and rigid behavior driven by kinematic interactions of scales. The response of the modified elastic beam strongly depends on the size and spatial overlap of rigid scales. The nonlinearity is perceptible even in relatively small strain regime and without invoking material level complexities of either the scales or the substrate.

  17. Drift Scale THM Model

    International Nuclear Information System (INIS)

    Rutqvist, J.

    2004-01-01

    This model report documents the drift scale coupled thermal-hydrological-mechanical (THM) processes model development and presents simulations of the THM behavior in fractured rock close to emplacement drifts. The modeling and analyses are used to evaluate the impact of THM processes on permeability and flow in the near-field of the emplacement drifts. The results from this report are used to assess the importance of THM processes on seepage and support in the model reports ''Seepage Model for PA Including Drift Collapse'' and ''Abstraction of Drift Seepage'', and to support arguments for exclusion of features, events, and processes (FEPs) in the analysis reports ''Features, Events, and Processes in Unsaturated Zone Flow and Transport and Features, Events, and Processes: Disruptive Events''. The total system performance assessment (TSPA) calculations do not use any output from this report. Specifically, the coupled THM process model is applied to simulate the impact of THM processes on hydrologic properties (permeability and capillary strength) and flow in the near-field rock around a heat-releasing emplacement drift. The heat generated by the decay of radioactive waste results in elevated rock temperatures for thousands of years after waste emplacement. Depending on the thermal load, these temperatures are high enough to cause boiling conditions in the rock, resulting in water redistribution and altered flow paths. These temperatures will also cause thermal expansion of the rock, with the potential of opening or closing fractures and thus changing fracture permeability in the near-field. Understanding the THM coupled processes is important for the performance of the repository because the thermally induced permeability changes potentially effect the magnitude and spatial distribution of percolation flux in the vicinity of the drift, and hence the seepage of water into the drift. This is important because a sufficient amount of water must be available within a

  18. Scale symmetry and virial theorem

    International Nuclear Information System (INIS)

    Westenholz, C. von

    1978-01-01

    Scale symmetry (or dilatation invariance) is discussed in terms of Noether's Theorem expressed in terms of a symmetry group action on phase space endowed with a symplectic structure. The conventional conceptual approach expressing invariance of some Hamiltonian under scale transformations is re-expressed in alternate form by infinitesimal automorphisms of the given symplectic structure. That is, the vector field representing scale transformations leaves the symplectic structure invariant. In this model, the conserved quantity or constant of motion related to scale symmetry is the virial. It is shown that the conventional virial theorem can be derived within this framework

  19. Large-scale solar purchasing

    International Nuclear Information System (INIS)

    1999-01-01

    The principal objective of the project was to participate in the definition of a new IEA task concerning solar procurement (''the Task'') and to assess whether involvement in the task would be in the interest of the UK active solar heating industry. The project also aimed to assess the importance of large scale solar purchasing to UK active solar heating market development and to evaluate the level of interest in large scale solar purchasing amongst potential large scale purchasers (in particular housing associations and housing developers). A further aim of the project was to consider means of stimulating large scale active solar heating purchasing activity within the UK. (author)

  20. Natural Scales in Geographical Patterns

    Science.gov (United States)

    Menezes, Telmo; Roth, Camille

    2017-04-01

    Human mobility is known to be distributed across several orders of magnitude of physical distances, which makes it generally difficult to endogenously find or define typical and meaningful scales. Relevant analyses, from movements to geographical partitions, seem to be relative to some ad-hoc scale, or no scale at all. Relying on geotagged data collected from photo-sharing social media, we apply community detection to movement networks constrained by increasing percentiles of the distance distribution. Using a simple parameter-free discontinuity detection algorithm, we discover clear phase transitions in the community partition space. The detection of these phases constitutes the first objective method of characterising endogenous, natural scales of human movement. Our study covers nine regions, ranging from cities to countries of various sizes and a transnational area. For all regions, the number of natural scales is remarkably low (2 or 3). Further, our results hint at scale-related behaviours rather than scale-related users. The partitions of the natural scales allow us to draw discrete multi-scale geographical boundaries, potentially capable of providing key insights in fields such as epidemiology or cultural contagion where the introduction of spatial boundaries is pivotal.

  1. Generic maximum likely scale selection

    DEFF Research Database (Denmark)

    Pedersen, Kim Steenstrup; Loog, Marco; Markussen, Bo

    2007-01-01

    in this work is on applying this selection principle under a Brownian image model. This image model provides a simple scale invariant prior for natural images and we provide illustrative examples of the behavior of our scale estimation on such images. In these illustrative examples, estimation is based......The fundamental problem of local scale selection is addressed by means of a novel principle, which is based on maximum likelihood estimation. The principle is generally applicable to a broad variety of image models and descriptors, and provides a generic scale estimation methodology. The focus...

  2. Collider Scaling and Cost Estimation

    International Nuclear Information System (INIS)

    Palmer, R.B.

    1986-01-01

    This paper deals with collider cost and scaling. The main points of the discussion are the following ones: 1) scaling laws and cost estimation: accelerating gradient requirements, total stored RF energy considerations, peak power consideration, average power consumption; 2) cost optimization; 3) Bremsstrahlung considerations; 4) Focusing optics: conventional, laser focusing or super disruption. 13 refs

  3. Voice, Schooling, Inequality, and Scale

    Science.gov (United States)

    Collins, James

    2013-01-01

    The rich studies in this collection show that the investigation of voice requires analysis of "recognition" across layered spatial-temporal and sociolinguistic scales. I argue that the concepts of voice, recognition, and scale provide insight into contemporary educational inequality and that their study benefits, in turn, from paying attention to…

  4. Spiritual Competency Scale: Further Analysis

    Science.gov (United States)

    Dailey, Stephanie F.; Robertson, Linda A.; Gill, Carman S.

    2015-01-01

    This article describes a follow-up analysis of the Spiritual Competency Scale, which initially validated ASERVIC's (Association for Spiritual, Ethical and Religious Values in Counseling) spiritual competencies. The study examined whether the factor structure of the Spiritual Competency Scale would be supported by participants (i.e., ASERVIC…

  5. Scaling as an Organizational Method

    DEFF Research Database (Denmark)

    Papazu, Irina Maria Clara Hansen; Nelund, Mette

    2018-01-01

    Organization studies have shown limited interest in the part that scaling plays in organizational responses to climate change and sustainability. Moreover, while scales are viewed as central to the diagnosis of the organizational challenges posed by climate change and sustainability, the role...... turn something as immense as the climate into a small and manageable problem, thus making abstract concepts part of concrete, organizational practice....

  6. The Assertiveness Scale for Children.

    Science.gov (United States)

    Peeler, Elizabeth; Rimmer, Susan M.

    1981-01-01

    Described an assertiveness scale for children developed to assess four dimensions of assertiveness across three categories of interpersonal situations. The scale was administered to elementary and middle school children (N=609) and readministered to students (N=164) to assess test-retest reliability. Test-retest reliability was low while internal…

  7. On the Geologic Time Scale

    NARCIS (Netherlands)

    Gradstein, F.M.; Ogg, J.G.; Hilgen, F.J.

    2012-01-01

    This report summarizes the international divisions and ages in the Geologic Time Scale, published in 2012 (GTS2012). Since 2004, when GTS2004 was detailed, major developments have taken place that directly bear and have considerable impact on the intricate science of geologic time scaling. Precam

  8. A Scale of Mobbing Impacts

    Science.gov (United States)

    Yaman, Erkan

    2012-01-01

    The aim of this research was to develop the Mobbing Impacts Scale and to examine its validity and reliability analyses. The sample of study consisted of 509 teachers from Sakarya. In this study construct validity, internal consistency, test-retest reliabilities and item analysis of the scale were examined. As a result of factor analysis for…

  9. Znamenny scale – fait accompli?

    Directory of Open Access Journals (Sweden)

    Alexei Yaropolov

    2010-12-01

    Full Text Available The author addresses one of the most sensitive topics of Znamenny chant: its scale. He tries to restore the “burned bridges” between ideographic and staff-notation of the Chant as he redefines and essentially generalizes the concept of scale as such. The possibility to artificially construct ad hoc many scales sounding sometimes very similar to the scale suggested by the modern staff-notation is a serious argument to regard the “staff-notation based” deciphering from the 17th century (dvoeznamenniki a pure game of chance. The constructed scales, presented in the paper, are different to “keyboard diatonica” and from one another and are never subject to the unified theorizing (unified nomenclature of degrees, etc. Critically commented is the practice to uncontrollably use the trivial pitch-symbols for deciphering, which ipso facto makes the probabilistic steps of unknown scales look as the ill-founded deviations from the diatonic scale steps, which are currently in use in the common musical education. This practice hinders the chance to acknowledge the right of the remote musical culture to rest on foundations that can be formulated both positively and explicitly, all the more so, as the usage of paleographic signs looks rather consistent. The resemblances and differences between musical cultures may be treated more liberally since no scale is seen a norm. The author is based on the writings of Russian musicologist and organologist Felix Raudonikas.

  10. Large-scale data analytics

    CERN Document Server

    Gkoulalas-Divanis, Aris

    2014-01-01

    Provides cutting-edge research in large-scale data analytics from diverse scientific areas Surveys varied subject areas and reports on individual results of research in the field Shares many tips and insights into large-scale data analytics from authors and editors with long-term experience and specialization in the field

  11. Gravitation on large scales

    Science.gov (United States)

    Giraud, E.

    A sample of dwarf and spiral galaxies with extended rotation curves is analysed, assuming that the fraction of dark matter is small. The objective of the paper is to prepare a framework for a theory, based on fundamental principles, that would give fits of the same quality as the phenomenology of dark halos. The following results are obtained: 1) The geodesics of massive systems with low density (Class I galaxies) can be described by the metric ds^2 = b^{-1}(r)dr^2 - b(r)dt^2 + r^2 dOmega^2 where b(r) = 1 - {2 over c^2}({{GM} over r} + gamma_f M^{1/2}) In this expression Gamma_f is a new fundamental constant which has been deduced from rotation curves of galaxies with circular velocity V_c^2 >= 2 {{GM} over r} for all r 2) The above metric is deduced from the conformal invariant metric ds^2 = B^{-1}(r)dr^2 - B(r)dt^2 + r^2 dOmega^2 where B(r) = 1 - {2 over c^2}({{GM} over r} + Gamma_f M^{1/2} + {1 over 3} {Gamma_f^2 over G}r) through a linear transform, u, of the linear special group SL(2, R) 3) The term {2 over c^2}Gamma_f M^{1/2} accounts for the difference between the observed rotation velocity and the Newtonian velocity. The term {2 over {3c^2}}{Gamma_f^2 over G}r is interpreted as a scale invariance between systems of different masses and sizes. 4) The metric B is a vacuum solution around a mass M deduced from the least action principle applied to the unique action I_a = -2 a int (-g)^{1/2} [R_{mu kappa}R^{ mu kappa} - 1/3(Ralphaalpha)^2] dx^4 built with the conformal Weyl tensor 5) For galaxies such that there is a radius, r_0, at which {{GM} over r_0} = Gamma M^{1/2} (Class II), the term Gamma M^{1/2} might be confined by the Newtonian potential yielding stationary solutions. 6) The analysed rotation curves of Class II galaxies are indeed well described with metrics of the form b(r) = 1 - {2 over c^2}({{GM} over r} + (n + 1) Gamma_0 M^{1/2}) where n is an integer and Gamma_0 = {1 over the square root of 3}Gamma_f 7) The effective potential is determined and

  12. Dynamic inequalities on time scales

    CERN Document Server

    Agarwal, Ravi; Saker, Samir

    2014-01-01

    This is a monograph devoted to recent research and results on dynamic inequalities on time scales. The study of dynamic inequalities on time scales has been covered extensively in the literature in recent years and has now become a major sub-field in pure and applied mathematics. In particular, this book will cover recent results on integral inequalities, including Young's inequality, Jensen's inequality, Holder's inequality, Minkowski's inequality, Steffensen's inequality, Hermite-Hadamard inequality and Čebyšv's inequality. Opial type inequalities on time scales and their extensions with weighted functions, Lyapunov type inequalities, Halanay type inequalities for dynamic equations on time scales, and Wirtinger type inequalities on time scales and their extensions will also be discussed here in detail.

  13. Entanglement scaling in lattice systems

    Energy Technology Data Exchange (ETDEWEB)

    Audenaert, K M R [Institute for Mathematical Sciences, Imperial College London, 53 Prince' s Gate, Exhibition Road, London SW7 2PG (United Kingdom); Cramer, M [QOLS, Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2BW (United Kingdom); Eisert, J [Institute for Mathematical Sciences, Imperial College London, 53 Prince' s Gate, Exhibition Road, London SW7 2PG (United Kingdom); Plenio, M B [Institute for Mathematical Sciences, Imperial College London, 53 Prince' s Gate, Exhibition Road, London SW7 2PG (United Kingdom)

    2007-05-15

    We review some recent rigorous results on scaling laws of entanglement properties in quantum many body systems. More specifically, we study the entanglement of a region with its surrounding and determine its scaling behaviour with its size for systems in the ground and thermal states of bosonic and fermionic lattice systems. A theorem connecting entanglement between a region and the rest of the lattice with the surface area of the boundary between the two regions is presented for non-critical systems in arbitrary spatial dimensions. The entanglement scaling in the field limit exhibits a peculiar difference between fermionic and bosonic systems. In one-spatial dimension a logarithmic divergence is recovered for both bosonic and fermionic systems. In two spatial dimensions in the setting of half-spaces however we observe strict area scaling for bosonic systems and a multiplicative logarithmic correction to such an area scaling in fermionic systems. Similar questions may be posed and answered in classical systems.

  14. GUT Scale Fermion Mass Ratios

    International Nuclear Information System (INIS)

    Spinrath, Martin

    2014-01-01

    We present a series of recent works related to group theoretical factors from GUT symmetry breaking which lead to predictions for the ratios of quark and lepton Yukawa couplings at the unification scale. New predictions for the GUT scale ratios y μ /y s , y τ /y b and y t /y b in particular are shown and compared to experimental data. For this comparison it is important to include possibly large supersymmetric threshold corrections. Due to this reason the structure of the fermion masses at the GUT scale depends on TeV scale physics and makes GUT scale physics testable at the LHC. We also discuss how this new predictions might lead to predictions for mixing angles by discussing the example of the recently measured last missing leptonic mixing angle θ 13 making this new class of GUT models also testable in neutrino experiments

  15. Convergent Validity of Four Innovativeness Scales.

    Science.gov (United States)

    Goldsmith, Ronald E.

    1986-01-01

    Four scales of innovativeness were administered to two samples of undergraduate students: the Open Processing Scale, Innovativeness Scale, innovation subscale of the Jackson Personality Inventory, and Kirton Adaption-Innovation Inventory. Intercorrelations indicated the scales generally exhibited convergent validity. (GDC)

  16. Cardiac Depression Scale: Mokken scaling in heart failure patients

    Directory of Open Access Journals (Sweden)

    Ski Chantal F

    2012-11-01

    Full Text Available Abstract Background There is a high prevalence of depression in patients with heart failure (HF that is associated with worsening prognosis. The value of using a reliable and valid instrument to measure depression in this population is therefore essential. We validated the Cardiac Depression Scale (CDS in heart failure patients using a model of ordinal unidimensional measurement known as Mokken scaling. Findings We administered in face-to-face interviews the CDS to 603 patients with HF. Data were analysed using Mokken scale analysis. Items of the CDS formed a statistically significant unidimensional Mokken scale of low strength (H0.8. Conclusions The CDS has a hierarchy of items which can be interpreted in terms of the increasingly serious effects of depression occurring as a result of HF. Identifying an appropriate instrument to measure depression in patients with HF allows for early identification and better medical management.

  17. Scale-by-scale contributions to Lagrangian particle acceleration

    Science.gov (United States)

    Lalescu, Cristian C.; Wilczek, Michael

    2017-11-01

    Fluctuations on a wide range of scales in both space and time are characteristic of turbulence. Lagrangian particles, advected by the flow, probe these fluctuations along their trajectories. In an effort to isolate the influence of the different scales on Lagrangian statistics, we employ direct numerical simulations (DNS) combined with a filtering approach. Specifically, we study the acceleration statistics of tracers advected in filtered fields to characterize the smallest temporal scales of the flow. Emphasis is put on the acceleration variance as a function of filter scale, along with the scaling properties of the relevant terms of the Navier-Stokes equations. We furthermore discuss scaling ranges for higher-order moments of the tracer acceleration, as well as the influence of the choice of filter on the results. Starting from the Lagrangian tracer acceleration as the short time limit of the Lagrangian velocity increment, we also quantify the influence of filtering on Lagrangian intermittency. Our work complements existing experimental results on intermittency and accelerations of finite-sized, neutrally-buoyant particles: for the passive tracers used in our DNS, feedback effects are neglected such that the spatial averaging effect is cleanly isolated.

  18. On inertial range scaling laws

    International Nuclear Information System (INIS)

    Bowman, J.C.

    1994-12-01

    Inertial-range scaling laws for two- and three-dimensional turbulence are re-examined within a unified framework. A new correction to Kolmogorov's k -5/3 scaling is derived for the energy inertial range. A related modification is found to Kraichnan's logarithmically corrected two-dimensional enstrophy cascade law that removes its unexpected divergence at the injection wavenumber. The significance of these corrections is illustrated with steady-state energy spectra from recent high-resolution closure computations. The results also underscore the asymptotic nature of inertial-range scaling laws. Implications for conventional numerical simulations are discussed

  19. Geometric scaling as traveling waves

    International Nuclear Information System (INIS)

    Munier, S.; Peschanski, R.

    2003-01-01

    We show the relevance of the nonlinear Fisher and Kolmogorov-Petrovsky-Piscounov (KPP) equation to the problem of high energy evolution of the QCD amplitudes. We explain how the traveling wave solutions of this equation are related to geometric scaling, a phenomenon observed in deep-inelastic scattering experiments. Geometric scaling is for the first time shown to result from an exact solution of nonlinear QCD evolution equations. Using general results on the KPP equation, we compute the velocity of the wave front, which gives the full high energy dependence of the saturation scale

  20. Straight scaling FFAG beam line

    International Nuclear Information System (INIS)

    Lagrange, J.-B.; Planche, T.; Yamakawa, E.; Uesugi, T.; Ishi, Y.; Kuriyama, Y.; Qin, B.; Okabe, K.; Mori, Y.

    2012-01-01

    Fixed field alternating gradient (FFAG) accelerators are recently subject to a strong revival. They are usually designed in a circular shape; however, it would be an asset to guide particles with no overall bend in this type of accelerator. An analytical development of a straight FFAG cell which keeps zero-chromaticity is presented here. A magnetic field law is thus obtained, called “straight scaling law”, and an experiment has been conducted to confirm this zero-chromatic law. A straight scaling FFAG prototype has been designed and manufactured, and horizontal phase advances of two different energies are measured. Results are analyzed to clarify the straight scaling law.

  1. Compositeness and the Fermi scale

    International Nuclear Information System (INIS)

    Peccei, R.D.

    1984-01-01

    The positive attitude adopted up to now, due to the non-observation of effects of substructure, is that the compositeness scale Λ must be large: Λ > or approx. 1 TeV. Such a large value of Λ gives rise to two theoretical problems which I examine here, namely: 1) What dynamics yields light composite quarks and leptons (msub(f) < < Λ) and 2) What relation does the compositeness scale Λ have with the Fermi scale Λsub(F) = (√2 Gsub(F))sup(-1/2) approx.= 250 GeV. (orig./HSI)

  2. Straight scaling FFAG beam line

    Science.gov (United States)

    Lagrange, J.-B.; Planche, T.; Yamakawa, E.; Uesugi, T.; Ishi, Y.; Kuriyama, Y.; Qin, B.; Okabe, K.; Mori, Y.

    2012-11-01

    Fixed field alternating gradient (FFAG) accelerators are recently subject to a strong revival. They are usually designed in a circular shape; however, it would be an asset to guide particles with no overall bend in this type of accelerator. An analytical development of a straight FFAG cell which keeps zero-chromaticity is presented here. A magnetic field law is thus obtained, called "straight scaling law", and an experiment has been conducted to confirm this zero-chromatic law. A straight scaling FFAG prototype has been designed and manufactured, and horizontal phase advances of two different energies are measured. Results are analyzed to clarify the straight scaling law.

  3. Japanese large-scale interferometers

    CERN Document Server

    Kuroda, K; Miyoki, S; Ishizuka, H; Taylor, C T; Yamamoto, K; Miyakawa, O; Fujimoto, M K; Kawamura, S; Takahashi, R; Yamazaki, T; Arai, K; Tatsumi, D; Ueda, A; Fukushima, M; Sato, S; Shintomi, T; Yamamoto, A; Suzuki, T; Saitô, Y; Haruyama, T; Sato, N; Higashi, Y; Uchiyama, T; Tomaru, T; Tsubono, K; Ando, M; Takamori, A; Numata, K; Ueda, K I; Yoneda, H; Nakagawa, K; Musha, M; Mio, N; Moriwaki, S; Somiya, K; Araya, A; Kanda, N; Telada, S; Sasaki, M; Tagoshi, H; Nakamura, T; Tanaka, T; Ohara, K

    2002-01-01

    The objective of the TAMA 300 interferometer was to develop advanced technologies for kilometre scale interferometers and to observe gravitational wave events in nearby galaxies. It was designed as a power-recycled Fabry-Perot-Michelson interferometer and was intended as a step towards a final interferometer in Japan. The present successful status of TAMA is presented. TAMA forms a basis for LCGT (large-scale cryogenic gravitational wave telescope), a 3 km scale cryogenic interferometer to be built in the Kamioka mine in Japan, implementing cryogenic mirror techniques. The plan of LCGT is schematically described along with its associated R and D.

  4. Hidden scale invariance of metals

    DEFF Research Database (Denmark)

    Hummel, Felix; Kresse, Georg; Dyre, Jeppe C.

    2015-01-01

    Density functional theory (DFT) calculations of 58 liquid elements at their triple point show that most metals exhibit near proportionality between the thermal fluctuations of the virial and the potential energy in the isochoric ensemble. This demonstrates a general “hidden” scale invariance...... of metals making the condensed part of the thermodynamic phase diagram effectively one dimensional with respect to structure and dynamics. DFT computed density scaling exponents, related to the Grüneisen parameter, are in good agreement with experimental values for the 16 elements where reliable data were...... available. Hidden scale invariance is demonstrated in detail for magnesium by showing invariance of structure and dynamics. Computed melting curves of period three metals follow curves with invariance (isomorphs). The experimental structure factor of magnesium is predicted by assuming scale invariant...

  5. Parity at the Planck scale

    Science.gov (United States)

    Arzano, Michele; Gubitosi, Giulia; Magueijo, João

    2018-06-01

    We explore the possibility that well known properties of the parity operator, such as its idempotency and unitarity, might break down at the Planck scale. Parity might then do more than just swap right and left polarized states and reverse the sign of spatial momentum k: it might generate superpositions of right and left handed states, as well as mix momenta of different magnitudes. We lay down the general formalism, but also consider the concrete case of the Planck scale kinematics governed by κ-Poincaré symmetries, where some of the general features highlighted appear explicitly. We explore some of the observational implications for cosmological fluctuations. Different power spectra for right handed and left handed tensor modes might actually be a manifestation of deformed parity symmetry at the Planck scale. Moreover, scale-invariance and parity symmetry appear deeply interconnected.

  6. Scaling of graphene integrated circuits.

    Science.gov (United States)

    Bianchi, Massimiliano; Guerriero, Erica; Fiocco, Marco; Alberti, Ruggero; Polloni, Laura; Behnam, Ashkan; Carrion, Enrique A; Pop, Eric; Sordan, Roman

    2015-05-07

    The influence of transistor size reduction (scaling) on the speed of realistic multi-stage integrated circuits (ICs) represents the main performance metric of a given transistor technology. Despite extensive interest in graphene electronics, scaling efforts have so far focused on individual transistors rather than multi-stage ICs. Here we study the scaling of graphene ICs based on transistors from 3.3 to 0.5 μm gate lengths and with different channel widths, access lengths, and lead thicknesses. The shortest gate delay of 31 ps per stage was obtained in sub-micron graphene ROs oscillating at 4.3 GHz, which is the highest oscillation frequency obtained in any strictly low-dimensional material to date. We also derived the fundamental Johnson limit, showing that scaled graphene ICs could be used at high frequencies in applications with small voltage swing.

  7. Large scale structure and baryogenesis

    International Nuclear Information System (INIS)

    Kirilova, D.P.; Chizhov, M.V.

    2001-08-01

    We discuss a possible connection between the large scale structure formation and the baryogenesis in the universe. An update review of the observational indications for the presence of a very large scale 120h -1 Mpc in the distribution of the visible matter of the universe is provided. The possibility to generate a periodic distribution with the characteristic scale 120h -1 Mpc through a mechanism producing quasi-periodic baryon density perturbations during inflationary stage, is discussed. The evolution of the baryon charge density distribution is explored in the framework of a low temperature boson condensate baryogenesis scenario. Both the observed very large scale of a the visible matter distribution in the universe and the observed baryon asymmetry value could naturally appear as a result of the evolution of a complex scalar field condensate, formed at the inflationary stage. Moreover, for some model's parameters a natural separation of matter superclusters from antimatter ones can be achieved. (author)

  8. Morocco - Small-Scale Fisheries

    Data.gov (United States)

    Millennium Challenge Corporation — The final performance evaluation roadmap for the Small-Scale Fisheries Project (PPA-MCC) is developed using a grid constructed around indicators relating to Project...

  9. Minimum scaling laws in tokamaks

    International Nuclear Information System (INIS)

    Zhang, Y.Z.; Mahajan, S.M.

    1986-10-01

    Scaling laws governing anomalous electron transport in tokamaks with ohmic and/or auxiliary heating are derived using renormalized Vlasov-Ampere equations for low frequency electromagnetic microturbulence. It is also shown that for pure auxiliary heating (or when auxiliary heating power far exceeds the ohmic power), the energy confinement time scales as tau/sub E/ ∼ P/sub inj//sup -1/3/, where P/sub inj/ is the injected power

  10. Scale issues in remote sensing

    CERN Document Server

    Weng, Qihao

    2014-01-01

    This book provides up-to-date developments, methods, and techniques in the field of GIS and remote sensing and features articles from internationally renowned authorities on three interrelated perspectives of scaling issues: scale in land surface properties, land surface patterns, and land surface processes. The book is ideal as a professional reference for practicing geographic information scientists and remote sensing engineers as well as a supplemental reading for graduate level students.

  11. Large-scale grid management

    International Nuclear Information System (INIS)

    Langdal, Bjoern Inge; Eggen, Arnt Ove

    2003-01-01

    The network companies in the Norwegian electricity industry now have to establish a large-scale network management, a concept essentially characterized by (1) broader focus (Broad Band, Multi Utility,...) and (2) bigger units with large networks and more customers. Research done by SINTEF Energy Research shows so far that the approaches within large-scale network management may be structured according to three main challenges: centralization, decentralization and out sourcing. The article is part of a planned series

  12. Normalization of emotion control scale

    Directory of Open Access Journals (Sweden)

    Hojatoolah Tahmasebian

    2014-09-01

    Full Text Available Background: Emotion control skill teaches the individuals how to identify their emotions and how to express and control them in various situations. The aim of this study was to normalize and measure the internal and external validity and reliability of emotion control test. Methods: This standardization study was carried out on a statistical society, including all pupils, students, teachers, nurses and university professors in Kermanshah in 2012, using Williams’ emotion control scale. The subjects included 1,500 (810 females and 690 males people who were selected by stratified random sampling. Williams (1997 emotion control scale, was used to collect the required data. Emotional Control Scale is a tool for measuring the degree of control people have over their emotions. This scale has four subscales, including anger, depressed mood, anxiety and positive affect. The collected data were analyzed by SPSS software using correlation and Cronbach's alpha tests. Results: The results of internal consistency of the questionnaire reported by Cronbach's alpha indicated an acceptable internal consistency for emotional control scale, and the correlation between the subscales of the test and between the items of the questionnaire was significant at 0.01 confidence level. Conclusion: The validity of emotion control scale among the pupils, students, teachers, nurses and teachers in Iran has an acceptable range, and the test itemswere correlated with each other, thereby making them appropriate for measuring emotion control.

  13. The Menopause Rating Scale (MRS scale: A methodological review

    Directory of Open Access Journals (Sweden)

    Strelow Frank

    2004-09-01

    Full Text Available Abstract Background This paper compiles data from different sources to get a first comprehensive picture of psychometric and other methodological characteristics of the Menopause Rating Scale (MRS scale. The scale was designed and standardized as a self-administered scale to (a to assess symptoms/complaints of aging women under different conditions, (b to evaluate the severity of symptoms over time, and (c to measure changes pre- and postmenopause replacement therapy. The scale became widespread used (available in 10 languages. Method A large multinational survey (9 countries in 4 continents from 2001/ 2002 is the basis for in depth analyses on reliability and validity of the MRS. Additional small convenience samples were used to get first impressions about test-retest reliability. The data were centrally analyzed. Data from a postmarketing HRT study were used to estimate discriminative validity. Results Reliability measures (consistency and test-retest stability were found to be good across countries, although the sample size for test-retest reliability was small. Validity: The internal structure of the MRS across countries was astonishingly similar to conclude that the scale really measures the same phenomenon in symptomatic women. The sub-scores and total score correlations were high (0.7–0.9 but lower among the sub-scales (0.5–0.7. This however suggests that the subscales are not fully independent. Norm values from different populations were presented showing that a direct comparison between Europe and North America is possible, but caution recommended with comparisons of data from Latin America and Indonesia. But this will not affect intra-individual comparisons within clinical trials. The comparison with the Kupperman Index showed sufficiently good correlations, illustrating an adept criterion-oriented validity. The same is true for the comparison with the generic quality-of-life scale SF-36 where also a sufficiently close association

  14. Mokken scaling of the Myocardial Infarction Dimensional Assessment Scale (MIDAS).

    Science.gov (United States)

    Thompson, David R; Watson, Roger

    2011-02-01

    The purpose of this study was to examine the hierarchical and cumulative nature of the 35 items of the Myocardial Infarction Dimensional Assessment Scale (MIDAS), a disease-specific health-related quality of life measure. Data from 668 participants who completed the MIDAS were analysed using the Mokken Scaling Procedure, which is a computer program that searches polychotomous data for hierarchical and cumulative scales on the basis of a range of diagnostic criteria. Fourteen MIDAS items were retained in a Mokken scale and these items included physical activity, insecurity, emotional reaction and dependency items but excluded items related to diet, medication or side-effects. Item difficulty, in item response theory terms, ran from physical activity items (low difficulty) to insecurity, suggesting that the most severe quality of life effect of myocardial infarction is loneliness and isolation. Items from the MIDAS form a strong and reliable Mokken scale, which provides new insight into the relationship between items in the MIDAS and the measurement of quality of life after myocardial infarction. © 2010 Blackwell Publishing Ltd.

  15. Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding.

    Directory of Open Access Journals (Sweden)

    Aleksey Malyshev

    Full Text Available Understanding single-neuron computations and encoding performed by spike-generation mechanisms of cortical neurons is one of the central challenges for cell electrophysiology and computational neuroscience. An established paradigm to study spike encoding in controlled conditions in vitro uses intracellular injection of a mixture of signals with fluctuating currents that mimic in vivo-like background activity. However this technique has two serious limitations: it uses current injection, while synaptic activation leads to changes of conductance, and current injection is technically most feasible in the soma, while the vast majority of synaptic inputs are located on the dendrites. Recent progress in optogenetics provides an opportunity to circumvent these limitations. Transgenic expression of light-activated ionic channels, such as Channelrhodopsin2 (ChR2, allows induction of controlled conductance changes even in thin distant dendrites. Here we show that photostimulation provides a useful extension of the tools to study neuronal encoding, but it has its own limitations. Optically induced fluctuating currents have a low cutoff (~70 Hz, thus limiting the dynamic range of frequency response of cortical neurons. This leads to severe underestimation of the ability of neurons to phase-lock their firing to high frequency components of the input. This limitation could be worked around by using short (2 ms light stimuli which produce membrane potential responses resembling EPSPs by their fast onset and prolonged decay kinetics. We show that combining application of short light stimuli to different parts of dendritic tree for mimicking distant EPSCs with somatic injection of fluctuating current that mimics fluctuations of membrane potential in vivo, allowed us to study fast encoding of artificial EPSPs photoinduced at different distances from the soma. We conclude that dendritic photostimulation of ChR2 with short light pulses provides a powerful tool to

  16. The Torino Impact Hazard Scale

    Science.gov (United States)

    Binzel, Richard P.

    2000-04-01

    Newly discovered asteroids and comets have inherent uncertainties in their orbit determinations owing to the natural limits of positional measurement precision and the finite lengths of orbital arcs over which determinations are made. For some objects making predictable future close approaches to the Earth, orbital uncertainties may be such that a collision with the Earth cannot be ruled out. Careful and responsible communication between astronomers and the public is required for reporting these predictions and a 0-10 point hazard scale, reported inseparably with the date of close encounter, is recommended as a simple and efficient tool for this purpose. The goal of this scale, endorsed as the Torino Impact Hazard Scale, is to place into context the level of public concern that is warranted for any close encounter event within the next century. Concomitant reporting of the close encounter date further conveys the sense of urgency that is warranted. The Torino Scale value for a close approach event is based upon both collision probability and the estimated kinetic energy (collision consequence), where the scale value can change as probability and energy estimates are refined by further data. On the scale, Category 1 corresponds to collision probabilities that are comparable to the current annual chance for any given size impactor. Categories 8-10 correspond to certain (probability >99%) collisions having increasingly dire consequences. While close approaches falling Category 0 may be no cause for noteworthy public concern, there remains a professional responsibility to further refine orbital parameters for such objects and a figure of merit is suggested for evaluating such objects. Because impact predictions represent a multi-dimensional problem, there is no unique or perfect translation into a one-dimensional system such as the Torino Scale. These limitations are discussed.

  17. The Internet Gaming Disorder Scale.

    Science.gov (United States)

    Lemmens, Jeroen S; Valkenburg, Patti M; Gentile, Douglas A

    2015-06-01

    Recently, the American Psychiatric Association included Internet gaming disorder (IGD) in the appendix of the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The main aim of the current study was to test the reliability and validity of 4 survey instruments to measure IGD on the basis of the 9 criteria from the DSM-5: a long (27-item) and short (9-item) polytomous scale and a long (27-item) and short (9-item) dichotomous scale. The psychometric properties of these scales were tested among a representative sample of 2,444 Dutch adolescents and adults, ages 13-40 years. Confirmatory factor analyses demonstrated that the structural validity (i.e., the dimensional structure) of all scales was satisfactory. Both types of assessment (polytomous and dichotomous) were also reliable (i.e., internally consistent) and showed good criterion-related validity, as indicated by positive correlations with time spent playing games, loneliness, and aggression and negative correlations with self-esteem, prosocial behavior, and life satisfaction. The dichotomous 9-item IGD scale showed solid psychometric properties and was the most practical scale for diagnostic purposes. Latent class analysis of this dichotomous scale indicated that 3 groups could be discerned: normal gamers, risky gamers, and disordered gamers. On the basis of the number of people in this last group, the prevalence of IGD among 13- through 40-year-olds in the Netherlands is approximately 4%. If the DSM-5 threshold for diagnosis (experiencing 5 or more criteria) is applied, the prevalence of disordered gamers is more than 5%. (c) 2015 APA, all rights reserved).

  18. Fusion power economy of scale

    International Nuclear Information System (INIS)

    Dolan, T.J.

    1993-01-01

    In the next 50 yr, the world will need to develop hundreds of gigawatts of non-fossil-fuel energy sources for production of electricity and fuels. Nuclear fusion can probably provide much of the required energy economically, if large single-unit power plants are acceptable. Large power plants are more common than most people realize: There are already many multiple-unit power plants producing 2 to 5 GW(electric) at a single site. The cost of electricity (COE) from fusion energy is predicted to scale as COE ∼ COE 0 (P/P 0 ) -n , where P is the electrical power, the subscript zero denotes reference values, and the exponent n ∼ 0.36 to 0.7 in various designs. The validity ranges of these scalings are limited and need to be extended by future work. The fusion power economy of scale derives from four interrelated effects: improved operations and maintenance costs; scaling of equipment unit costs; a geometric effect that increases the mass power density; and reduction of the recirculating power fraction. Increased plasma size also relaxes the required confinement parameters: For the same neutron wall loading, larger tokamaks can use lower magnetic fields. Fossil-fuel power plants have a weaker economy of scale than fusion because the fuel costs constitute much of their COE. Solar and wind power plants consist of many small units, so they have little economy of scale. Fission power plants have a strong economy of scale but are unable to exploit it because the maximum unit size is limited by safety concerns. Large, steady-state fusion reactors generating 3 to 6 GW(electric) may be able to produce electricity for 4 to 5 cents/kW·h, which would be competitive with other future energy sources. 38 refs., 6 figs., 6 tabs

  19. Copper atomic-scale transistors.

    Science.gov (United States)

    Xie, Fangqing; Kavalenka, Maryna N; Röger, Moritz; Albrecht, Daniel; Hölscher, Hendrik; Leuthold, Jürgen; Schimmel, Thomas

    2017-01-01

    We investigated copper as a working material for metallic atomic-scale transistors and confirmed that copper atomic-scale transistors can be fabricated and operated electrochemically in a copper electrolyte (CuSO 4 + H 2 SO 4 ) in bi-distilled water under ambient conditions with three microelectrodes (source, drain and gate). The electrochemical switching-on potential of the atomic-scale transistor is below 350 mV, and the switching-off potential is between 0 and -170 mV. The switching-on current is above 1 μA, which is compatible with semiconductor transistor devices. Both sign and amplitude of the voltage applied across the source and drain electrodes ( U bias ) influence the switching rate of the transistor and the copper deposition on the electrodes, and correspondingly shift the electrochemical operation potential. The copper atomic-scale transistors can be switched using a function generator without a computer-controlled feedback switching mechanism. The copper atomic-scale transistors, with only one or two atoms at the narrowest constriction, were realized to switch between 0 and 1 G 0 ( G 0 = 2e 2 /h; with e being the electron charge, and h being Planck's constant) or 2 G 0 by the function generator. The switching rate can reach up to 10 Hz. The copper atomic-scale transistor demonstrates volatile/non-volatile dual functionalities. Such an optimal merging of the logic with memory may open a perspective for processor-in-memory and logic-in-memory architectures, using copper as an alternative working material besides silver for fully metallic atomic-scale transistors.

  20. Resiliency Scale (RS): Scale Development, Reliability and Validity Study

    OpenAIRE

    GÜRGAN, Uğur

    2003-01-01

    The purpose of this study was to develop a new Resiliency Scale (RS) for Turkish samples. Various items from some major resiliency scales, most of them with some partial change, were collected and a pool of 228 items containing almost all possible resilience areas were obtained. This item-pool was administered to a college sample of 419. Resulting of analysis 50 item RS were obtained and administered to a new college sample of 112 participants. This second sample has also received the Rosenba...

  1. Scale Construction: Motivation and Relationship Scale in Education

    Directory of Open Access Journals (Sweden)

    Yunus Emre Demir

    2016-01-01

    Full Text Available The aim of this study is to analyze the validity and reliability of the Turkish version of Motivation and Relationship Scale (MRS, (Raufelder , Drury , Jagenow , Hoferichter & Bukowski , 2013.Participants were 526 students of secondary school. The results of confirmatory factor analysis described that the 21 items loaded three factor and the three-dimensional model was well fit (x2= 640.04, sd= 185, RMSEA= .068, NNFI= .90, CFI = .91, IFI=.91,SRMR=079, GFI= .90,AGFI=.87. Overall findings demonstrated that this scale is a valid and indicates that the adapted MRS is a valid instrument for measuring secondary school children’s motivation in Turkey.

  2. Scaling laws of Rydberg excitons

    Science.gov (United States)

    Heckötter, J.; Freitag, M.; Fröhlich, D.; Aßmann, M.; Bayer, M.; Semina, M. A.; Glazov, M. M.

    2017-09-01

    Rydberg atoms have attracted considerable interest due to their huge interaction among each other and with external fields. They demonstrate characteristic scaling laws in dependence on the principal quantum number n for features such as the magnetic field for level crossing or the electric field of dissociation. Recently, the observation of excitons in highly excited states has allowed studying Rydberg physics in cuprous oxide crystals. Fundamentally different insights may be expected for Rydberg excitons, as the crystal environment and associated symmetry reduction compared to vacuum give not only optical access to many more states within an exciton multiplet but also extend the Hamiltonian for describing the exciton beyond the hydrogen model. Here we study experimentally and theoretically the scaling of several parameters of Rydberg excitons with n , for some of which we indeed find laws different from those of atoms. For others we find identical scaling laws with n , even though their origin may be distinctly different from the atomic case. At zero field the energy splitting of a particular multiplet n scales as n-3 due to crystal-specific terms in the Hamiltonian, e.g., from the valence band structure. From absorption spectra in magnetic field we find for the first crossing of levels with adjacent principal quantum numbers a Br∝n-4 dependence of the resonance field strength, Br, due to the dominant paramagnetic term unlike for atoms for which the diamagnetic contribution is decisive, resulting in a Br∝n-6 dependence. By contrast, the resonance electric field strength shows a scaling as Er∝n-5 as for Rydberg atoms. Also similar to atoms with the exception of hydrogen we observe anticrossings between states belonging to multiplets with different principal quantum numbers at these resonances. The energy splittings at the avoided crossings scale roughly as n-4, again due to crystal specific features in the exciton Hamiltonian. The data also allow us to

  3. Divertor scaling laws for tokamaks

    International Nuclear Information System (INIS)

    Catto, P.J.; Krasheninnikov, S.I.; Connor, J.W.

    1997-01-01

    The breakdown of two body scaling laws is illustrated by using the two dimensional plasma code UEDGE coupled to an advanced Navier-Stokes neutrals transport package to model attached and detached regimes in a simplified geometry. Two body similarity scalings are used as benchmarks for runs retaining non-two body modifications due to the effects of (i) multi-step processes altering ionization and radiation via the excited states of atomic hydrogen and (ii) three body recombination. Preliminary investigations indicate that two body scaling interpretations of experimental data fail due to (i) multi-step processes when a significant region of the plasma exceeds a plasma density of 10 19 m -3 , or (ii) three body recombination when there is a significant region in which the temperature is ≤1 eV while the plasma density is ≥10 20 m -3 . These studies demonstrate that two body scaling arguments are often inappropriate in the divertor and the first results for alternate scalings are presented. (orig.)

  4. Scales of Natural Flood Management

    Science.gov (United States)

    Nicholson, Alex; Quinn, Paul; Owen, Gareth; Hetherington, David; Piedra Lara, Miguel; O'Donnell, Greg

    2016-04-01

    The scientific field of Natural flood Management (NFM) is receiving much attention and is now widely seen as a valid solution to sustainably manage flood risk whilst offering significant multiple benefits. However, few examples exist looking at NFM on a large scale (>10km2). Well-implemented NFM has the effect of restoring more natural catchment hydrological and sedimentological processes, which in turn can have significant flood risk and WFD benefits for catchment waterbodies. These catchment scale improvements in-turn allow more 'natural' processes to be returned to rivers and streams, creating a more resilient system. Although certain NFM interventions may appear distant and disconnected from main stem waterbodies, they will undoubtedly be contributing to WFD at the catchment waterbody scale. This paper offers examples of NFM, and explains how they can be maximised through practical design across many scales (from feature up to the whole catchment). New tools to assist in the selection of measures and their location, and to appreciate firstly, the flooding benefit at the local catchment scale and then show a Flood Impact Model that can best reflect the impacts of local changes further downstream. The tools will be discussed in the context of our most recent experiences on NFM projects including river catchments in the north east of England and in Scotland. This work has encouraged a more integrated approach to flood management planning that can use both traditional and novel NFM strategies in an effective and convincing way.

  5. Visions of Atomic Scale Tomography

    International Nuclear Information System (INIS)

    Kelly, T.F.; Miller, Michael K.; Rajan, Krishna; Ringer, S.P.

    2012-01-01

    A microscope, by definition, provides structural and analytical information about objects that are too small to see with the unaided eye. From the very first microscope, efforts to improve its capabilities and push them to ever-finer length scales have been pursued. In this context, it would seem that the concept of an ultimate microscope would have received much attention by now; but has it really ever been defined? Human knowledge extends to structures on a scale much finer than atoms, so it might seem that a proton-scale microscope or a quark-scale microscope would be the ultimate. However, we argue that an atomic-scale microscope is the ultimate for the following reason: the smallest building block for either synthetic structures or natural structures is the atom. Indeed, humans and nature both engineer structures with atoms, not quarks. So far as we know, all building blocks (atoms) of a given type are identical; it is the assembly of the building blocks that makes a useful structure. Thus, would a microscope that determines the position and identity of every atom in a structure with high precision and for large volumes be the ultimate microscope? We argue, yes. In this article, we consider how it could be built, and we ponder the answer to the equally important follow-on questions: who would care if it is built, and what could be achieved with it?

  6. "I Gave up MySpace for Lent": New Teachers and Social Networking Sites

    Science.gov (United States)

    Kist, William

    2008-01-01

    This Digital Literacies column describes the dilemma many new teachers feel as their uses of social networking sites pose conflicts with institutional cautions regarding educators' participation in these kinds of online activities. Pre-service teachers discuss the challenges of marrying their own out-of-school literacies to mandated professional…

  7. Resistance to starvation of Rhodnius neivai Lent, 1953 (Hemiptera: Reduviidae: Triatominae under experimental conditions

    Directory of Open Access Journals (Sweden)

    Daniel R Cabello

    2001-05-01

    Full Text Available The period of resistance to starvation and the loss of weight until death of Rhodnius neivai in all stages of development were studied. Work was based on experiments conducted under controlled laboratory conditions. One hundred specimens of each nymphal instar were observed: 50 were fed on chicken and 50 on rabbit. Adult females and males were kept together and fed on each host. All bugs were weighed weekly until death. Laid eggs were collected weekly and observed during five weeks to obtain hatchability. Resistance to starvation was similar with both hosts and increased with the evolutionary stage, excepting the 5th nymphal instar and adults. With both hosts, loss of weight was abrupt in the first week and steady in the following weeks. In adults, on the first weeks after eating, there was little or no mortality, after which mortality increased rapidly with the starving time. Reproductive output was higher in the bugs fed on rabbit. R. neivai is among the least resistant triatomine species.

  8. A Lente da Fenomenologia de Merleau-Ponty para a Psicopatologia Cultural

    Directory of Open Access Journals (Sweden)

    Thabata Castelo Branco Telles

    Full Text Available Este artigo tem o objetivo de apontar contribuições da fenomenologia de Merleau-Ponty para a psicopatologia cultural. Discutimos alguns temas presentes nessa filosofia associados a ideias contidas nas pesquisas recentes em psicopatologia cultural, tais como corpo, liberdade, linguagem, arte e cultura. Destacamos a discussão realizada por Merleau-Ponty acerca das obras do pintor Paul Cézanne como contribuição para um novo olhar sobre a psicopatologia cultural, ressaltando a ambiguidade presente nos processos de adoecimento e nas distintas nuanças que se entrelaçam na experiência vivida de sofrimento.

  9. Glosa paseada bajo el fuego y la lluvia: cinco lentes para mirar el Chocó

    Directory of Open Access Journals (Sweden)

    Mónica María del Valle Idárraga

    2011-12-01

    Full Text Available A partir de la perspectiva general de la ecocrítica o ecopoética, este artículo analiza los modos como se representa la naturaleza y su relación con lo humano en la obra Glosa paseada bajo el fuego y la lluvia (1982 del escritor chocoano Carlos Arturo Caicedo Licona. Las cinco instancias de esa figuración que aquí se estudian ayudan a crear un universo simbólico que respalda una idea de chocoanidad cifrada en prácticas, creencias, recorridos y visiones desde un marco anterior a tecnologías de la identidad como la biodiversidad o la patrimonialización.Based on the general premises of Ecocriticism, this article explores the ways in which nature and its inter-relation to human beings is created in Glosa paseada bajo el fuego y la lluvia, a work by Carlos Arturo Caicedo Licona, a writer from Chocó, Colombia. Five instances of that representation are analyzed as pieces that, while describing practices, conceptions, beliefs and cartographic descriptions, structure an idea of Chocoan identity previous to current identity technologies, such as patrimonialization and biodiversity.

  10. Dynamique de l'éjection lente et son influence sur les lignes de transfert

    CERN Document Server

    Pullia, M; Amaldi, Ugo; Bryant, P J; Chambon, B

    1999-01-01

    The treatment of cancer with accelerator beams has a long history with linacs, cyclotrons and now synchrotrons being exploited for this purpose. Treatment techniques can be broadly divided into the use of spread-out beams and scanned 'pencil' beams. The Bragg-peak behaviour of charged hadrons makes them ideal candidates for the latter. The combination of precisely focused 'pencil' beams with controllable penetration (Bragg peak) and high, radio-biological efficiency (light ions) opens the way to treating the more awkward tumours that are radio-resistant, complex in shape and lodged against critical organs. To accelerate light ions (carbon) with pulse-to-pulse energy variation, a synchrotron is the natural choice. The beam scanning system is controlled via an on-line measurement of the particle flux entering the patient and, for this reason, the beam spill must be extended in time (seconds) by a slow-extraction scheme. The quality of the dose intensity profile ultimately depends on the uniformity of the beam s...

  11. Portfolio langagier : Les finissants des programmes d’immersion se révèlent

    Directory of Open Access Journals (Sweden)

    Lucille Mandin

    2010-02-01

    Full Text Available This article presents a research conducted with French Immersion graduates in the context of an introductory language methodology course in a francophone institution. The participants completed a language portfolio, created by Laplante & Christiansen (2001. The portfolio consisted of a two-page autobiographical narrative entitled 'My Life in French till now', an action plan which included an analysis of the errors they identified as targets for that semester and the means or the tools they chose to correct the errors. An analysis of the autobiographical narrative, a document written by the individual participants, stemming from their life experiences since they were exposed to the French language, is presented. The narrative is inspired by the values they have developed and the choices they have made concerning learning French (Baumeister, 1991; Kenyon, 1999. This study also presents a profile of significant experiences these French Immersion graduates identify as pivotal in their motivation to pursue their postsecondary studies in French. They also highlight teachers, friends and family who played an important role during 'their lives in French' till now. In their action plan, the students identified categories of linguistic challenges in areas such as semantics, syntax and phonology. These results shed light on questions pertaining to best practices in French Immersion programs.

  12. OTRA MIRADA EN EL LUGAR: manejar las lentes para redescubrir el espacio vivido

    Directory of Open Access Journals (Sweden)

    Hanilton Ribeiro de Souza

    2013-12-01

    Full Text Available RESUMEN: Teniendo como referencia la importancia de la relación con la ciudad como espacio vivido y las diversas formas de percibirla, en este trabalho buscamos compartir las experiencias construidas conjuntamente entre profesores/as del curso de Licenciatura en Geografia de la Universidad del Estado de Bahia (UNEB– Campus V – Santo Antonio de Jesus/BA y estudiantes de la enseñanza media del Colegio Estadual Polivalente de Castro Alves, localizado en el municipio del mismo nombre. Reunimos reflexiones sobre nuestras experiencias analizando producciones innovadoras como resultado de las actividades elaboradas por los sujeitos involucrados em las prácticas vividas cotidianamente em el ambiente escolar em contraposición con los pensamientos e ideas creados cotidianamente em el mundo académico de los/las autores, centrándonos en el mundo de las imágenes y en el potencial de construcción del conocimiento dentro del mundo de la educación. Además, procuramos resaltar la importancia de la construcción colectiva e interdisciplinar del conocimiento orientada por la concepción curricular presente en las propuestas de las prácticas indicadas por los/las professores/as de Geografía. RESUMO: Tendo como referência a importância da relação com a cidade como espaço vivido e as diversas maneiras de percebê-la, neste trabalho buscamos partilhar as experiências construídas conjuntamente entre professores/as do curso de Licenciatura em Geografia da Universidade do Estado da Bahia (UNEB – Campus V – Santo Antonio de Jesus/BA e discentes do ensino médio do Colégio Estadual Polivalente de Castro Alves, localizado no município de mesmo nome. Reunimos reflexões oriundas das nossas experimentações analisando produções inovadoras como resultado das atividades elaboradas pelos/os sujeitos envolvidos nas práticas vivenciadas no cotidiano escolar em confronto com pensamentos e ideias forjadas no cotidiano acadêmico dos/as autores/as. Para tal feito, a premissa mais importante aqui confere ao mundo das imagens o potencial de descobertas e construção de conhecimento em sua interface com o mundo da educação. Ademais, procuramos evidenciar a importância da construção coletiva e interdisciplinar orientada pela concepção curricular presente nas proposições das práticas indicadas pelos/as professores/as em Geografia.

  13. Una súplica por nuestro futuro: lenguaje, tecnología y la lente masculina

    Directory of Open Access Journals (Sweden)

    Claudia Herbst

    2005-01-01

    Full Text Available This essay takes a look at the vital role of code literacy in women’s futures and argues that the future of women’s opportunity to participate in the definition of knowledge, its construction and dissemination, is intricately tied up in the developments that are currently taking place at the junction where language and technology intersect. My claims are bold and at the heart of them, the question of literacy –an exclusionary mechanism that historically has been applied in the oppression of women– rears its gendered head. The ensuing discussion is deliberately polemical and proposes that the future of feminism lies in the realm of technology.

  14. Los lentes oscuros: persecuciones de la ausencia en el media art.

    Directory of Open Access Journals (Sweden)

    Teresa Sorolla Romero

    2014-08-01

    Full Text Available Esta investigación explora el entorpecimiento de la visualidad como un gesto estético que advertimos con cierta insistencia en el new media art, que se sirve, en ocasiones, de la utilización de las tecnologías emergentes de los medios de comunicación para hacer florecer zonas silenciosas en la visualidad. El estudio parte de la siguiente hipótesis: el new media art destina las posibilidades estéticas del registro y la creación digital para convocar algo del orden del vacío. Para desarrollarla, seguimos el método hipotético-deductivo. Planteamos la hipótesis, formulada a través de una exploración previa de prácticas culturales del media art que después tratamos de comprometer a través del estudio de un corpus de prácticas artísticas fotográficas y videográficas y la lectura de estas desde la tradición estética y filosófica del arte.   

  15. A través de la lente: Otto Moll González

    Directory of Open Access Journals (Sweden)

    Tatiana Urrea Uyabán

    2012-06-01

    Full Text Available La fotografía arquitectónica de Otto Moll se encanta con las propuestas de las firmas que despuntan en el decenio de 1950 y que conformarán ese Cali de verdad moderno. Un aire estadounidense que no necesariamente se integra al entorno natural. Resaltan los proyectos sobre ese terreno que antaño fue un bosque seco. La arquitectura es el objeto; más allá del juego de luces y sombras y de la técnica. Moll como ningún otro para entonces, saca a la luz la propuesta que despunta con estos proyectos. Serán la representación del "Movimiento Moderno" y quienes encargan los trabajos al fotógrafo van también a la vanguardia.

  16. Pair plasma relaxation time scales.

    Science.gov (United States)

    Aksenov, A G; Ruffini, R; Vereshchagin, G V

    2010-04-01

    By numerically solving the relativistic Boltzmann equations, we compute the time scale for relaxation to thermal equilibrium for an optically thick electron-positron plasma with baryon loading. We focus on the time scales of electromagnetic interactions. The collisional integrals are obtained directly from the corresponding QED matrix elements. Thermalization time scales are computed for a wide range of values of both the total-energy density (over 10 orders of magnitude) and of the baryonic loading parameter (over 6 orders of magnitude). This also allows us to study such interesting limiting cases as the almost purely electron-positron plasma or electron-proton plasma as well as intermediate cases. These results appear to be important both for laboratory experiments aimed at generating optically thick pair plasmas as well as for astrophysical models in which electron-positron pair plasmas play a relevant role.

  17. Scaling and prescaling in quarkonium

    International Nuclear Information System (INIS)

    Warner, R.C.; Joshi, G.C.

    1979-01-01

    Recent experiments in the upsilon region indicate the quark mass dependence of quark-antiquark bound state properties. Classes of quark-antiquark potentials exhibiting scaling of energy level spacing with quark mass are presented, and the importance of mass dependence of bound state properties in investigating the nature of the potential is emphasised. The scaling potentials considered are V=V(msup(1/2)r), which exhibits constant level spacing, and V=bmsup(α)rsup(β), and its generalizations, which has scaling of energy levels controlled by the exponents α and β. The class of potentials yielding constant level spacing is shown to be consistent with the interpretation of the state recently observed at 9.46 GeV in e + e - annihilations as a bound state of a new quark and antiquark with esub(p)=1/3

  18. The Satisfaction With Life Scale.

    Science.gov (United States)

    Diener, E; Emmons, R A; Larsen, R J; Griffin, S

    1985-02-01

    This article reports the development and validation of a scale to measure global life satisfaction, the Satisfaction With Life Scale (SWLS). Among the various components of subjective well-being, the SWLS is narrowly focused to assess global life satisfaction and does not tap related constructs such as positive affect or loneliness. The SWLS is shown to have favorable psychometric properties, including high internal consistency and high temporal reliability. Scores on the SWLS correlate moderately to highly with other measures of subjective well-being, and correlate predictably with specific personality characteristics. It is noted that the SWLS is Suited for use with different age groups, and other potential uses of the scale are discussed.

  19. Bench-scale/field-scale interpretations: Session overview

    International Nuclear Information System (INIS)

    Cunningham, A.B.; Peyton, B.M.

    1995-04-01

    In situ bioremediation involves complex interactions between biological, chemical, and physical processes and requires integration of phenomena operating at scales ranging from that of a microbial cell (10 -6 ) to that of a remediation site (10 to 1000 m). Laboratory investigations of biodegradation are usually performed at a relatively small scale, governed by convenience, cost, and expedience. However, extending the results from a laboratory-scale experimental system to the design and operation of a field-scale system introduces (1) additional mass transport mechanisms and limitations; (2) the presence of multiple phases, contants, and competing microorganisms (3) spatial geologic heterogeneities; and (4) subsurface environmental factors that may inhibit bacterial growth such as temperature, pH, nutrient, or redox conditions. Field bioremediation rates may be limited by the availability of one of the necessary constituents for biotransformation: substrate, contaminant, electron acceptor, nutrients, or microorganisms capable of degrading the target compound. The factor that limits the rate of bioremediation may not be the same in the laboratory as it is in the field, thereby leading, to development of unsuccessful remediation strategies

  20. Status of xi-scaling

    International Nuclear Information System (INIS)

    Politzer, H.D.

    1977-01-01

    The logic of the xi-scaling analysis of inclusive lepton-hadron scattering is reviewed with the emphasis on clarifying what is assumed and what is predicted. The physics content of several recent papers, which purport to criticize this analysis, in fact confirm its validity and utility. For clarity, concentration is placed on the orthodox operator product analysis of electroproduction, local duality and precocious scaling. Other physics discussed includes the successes of QCD in the rate of charm production in muon inelastic scattering and in the energy--momentum sum rule. Gluons

  1. Shadowing in the scaling region

    International Nuclear Information System (INIS)

    Shaw, G.

    1989-01-01

    The approximate scaling behaviour of the shadowing effect at small χ, recently observed in deep inelastic muon scattering experiments on nuclei, is shown to arise naturally at very large ν in those hadron dominance models, formulated many years ago, which are dual to the parton model. At smaller ν small scale breaking effects are expected, which sould die away as ν increases. The predicted shadowing decreases rapidly with increasing χ, at a rate which is only weakly dependent on the atomic number A for reasonably large A. (orig.)

  2. Learning From the Furniture Scale

    DEFF Research Database (Denmark)

    Hvejsel, Marie Frier; Kirkegaard, Poul Henning

    2018-01-01

    Given its proximity to the human body, the furniture scale holds a particular potential in grasping the fundamental aesthetic potential of architecture to address its inhabitants by means of spatial ‘gestures’. Likewise, it holds a technical germ in realizing this potential given its immediate...... tangibility allowing experimentation with the ‘principles’ of architectural construction. In present paper we explore this dual tectonic potential of the furniture scale as an epistemological foundation in architectural education. In this matter, we discuss the conduct of a master-level course where we...

  3. Pelamis WEC - intermediate scale demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Yemm, R.

    2003-07-01

    This report describes the successful building and commissioning of an intermediate 1/7th scale model of the Pelamis Wave Energy Converter (WEC) and its testing in the wave climate of the Firth of Forth. Details are given of the design of the semi-submerged articulated structure of cylindrical elements linked by hinged joints. The specific programme objectives and conclusions, development issues addressed, and key remaining risks are discussed along with development milestones to be passed before the Pelamis WEC is ready for full-scale prototype testing.

  4. Organizational Scale and School Success.

    Science.gov (United States)

    Guthrie, James W.

    1979-01-01

    The relationship between the organizational scale of schooling (school and school district size) and school success is examined. The history of the movement toward larger school units, the evidence of the effects of that movement, and possible research strategies for further investigation of the issue are discussed. (JKS)

  5. Scaling up of renewable chemicals.

    Science.gov (United States)

    Sanford, Karl; Chotani, Gopal; Danielson, Nathan; Zahn, James A

    2016-04-01

    The transition of promising technologies for production of renewable chemicals from a laboratory scale to commercial scale is often difficult and expensive. As a result the timeframe estimated for commercialization is typically underestimated resulting in much slower penetration of these promising new methods and products into the chemical industries. The theme of 'sugar is the next oil' connects biological, chemical, and thermochemical conversions of renewable feedstocks to products that are drop-in replacements for petroleum derived chemicals or are new to market chemicals/materials. The latter typically offer a functionality advantage and can command higher prices that result in less severe scale-up challenges. However, for drop-in replacements, price is of paramount importance and competitive capital and operating expenditures are a prerequisite for success. Hence, scale-up of relevant technologies must be interfaced with effective and efficient management of both cell and steel factories. Details involved in all aspects of manufacturing, such as utilities, sterility, product recovery and purification, regulatory requirements, and emissions must be managed successfully. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Metrology at the nano scale

    International Nuclear Information System (INIS)

    Sheridan, B.; Cumpson, P.; Bailey, M.

    2006-01-01

    Progress in nano technology relies on ever more accurate measurements of quantities such as distance, force and current industry has long depended on accurate measurement. In the 19th century, for example, the performance of steam engines was seriously limited by inaccurately made components, a situation that was transformed by Henry Maudsley's screw micrometer calliper. And early in the 20th century, the development of telegraphy relied on improved standards of electrical resistance. Before this, each country had its own standards and cross border communication was difficult. The same is true today of nano technology if it is to be fully exploited by industry. Principles of measurement that work well at the macroscopic level often become completely unworkable at the nano metre scale - about 100 nm and below. Imaging, for example, is not possible on this scale using optical microscopes, and it is virtually impossible to weigh a nano metre-scale object with any accuracy. In addition to needing more accurate measurements, nano technology also often requires a greater variety of measurements than conventional technology. For example, standard techniques used to make microchips generally need accurate length measurements, but the manufacture of electronics at the molecular scale requires magnetic, electrical, mechanical and chemical measurements as well. (U.K.)

  7. Inviscid criterion for decomposing scales

    Science.gov (United States)

    Zhao, Dongxiao; Aluie, Hussein

    2018-05-01

    The proper scale decomposition in flows with significant density variations is not as straightforward as in incompressible flows, with many possible ways to define a "length scale." A choice can be made according to the so-called inviscid criterion [Aluie, Physica D 24, 54 (2013), 10.1016/j.physd.2012.12.009]. It is a kinematic requirement that a scale decomposition yield negligible viscous effects at large enough length scales. It has been proved [Aluie, Physica D 24, 54 (2013), 10.1016/j.physd.2012.12.009] recently that a Favre decomposition satisfies the inviscid criterion, which is necessary to unravel inertial-range dynamics and the cascade. Here we present numerical demonstrations of those results. We also show that two other commonly used decompositions can violate the inviscid criterion and, therefore, are not suitable to study inertial-range dynamics in variable-density and compressible turbulence. Our results have practical modeling implication in showing that viscous terms in Large Eddy Simulations do not need to be modeled and can be neglected.

  8. Geometric scaling in exclusive processes

    International Nuclear Information System (INIS)

    Munier, S.; Wallon, S.

    2003-01-01

    We show that according to the present understanding of the energy evolution of the observables measured in deep-inelastic scattering, the photon-proton scattering amplitude has to exhibit geometric scaling at each impact parameter. We suggest a way to test this experimentally at HERA. A qualitative analysis based on published data is presented and discussed. (orig.)

  9. An Assertiveness Scale for Adolescents.

    Science.gov (United States)

    Lee, Dong Yul; And Others

    1985-01-01

    Developed a 33-item, situation-specific instrument that measures assertiveness of adolescents. Based on data from 682 elementary and secondary school students, adequate reliability and validity of the Assertiveness Scale for Adolescents (ASA) were obtained when tested against several variables about which predictions could be made. (BH)

  10. A Feminist Family Therapy Scale.

    Science.gov (United States)

    Black, Leora; Piercy, Fred P.

    1991-01-01

    Reports on development and psychometric properties of Feminist Family Therapy Scale (FFTS), a 17-item instrument intended to reflect degree to which family therapists conceptualize process of family therapy from feminist-informed perspective. Found that the instrument discriminated between self-identified feminists and nonfeminists, women and men,…

  11. National Image Interpretablility Rating Scales

    OpenAIRE

    2003-01-01

    Interactive Media Element This presentation media demonstrates the NIIRS scale and resolution numbers and presents a problem statement to help the student gain an intuitive understanding of the numbers. Last modified: 5/18/2009 ME3XXX Military Applications of Unmanned Air Vehicles/Remotely Operated Aircraft (UAV/ROA)

  12. Animal coloration: sexy spider scales.

    Science.gov (United States)

    Taylor, Lisa A; McGraw, Kevin J

    2007-08-07

    Many male jumping spiders display vibrant colors that are used in visual communication. A recent microscopic study on a jumping spider from Singapore shows that three-layered 'scale sandwiches' of chitin and air are responsible for producing their brilliant iridescent body coloration.

  13. Salzburger State Reactance Scale (SSR Scale): Validation of a Scale Measuring State Reactance.

    Science.gov (United States)

    Sittenthaler, Sandra; Traut-Mattausch, Eva; Steindl, Christina; Jonas, Eva

    This paper describes the construction and empirical evaluation of an instrument for measuring state reactance, the Salzburger State Reactance (SSR) Scale. The results of a confirmatory factor analysis supported a hypothesized three-factor structure: experience of reactance, aggressive behavioral intentions, and negative attitudes. Correlations with divergent and convergent measures support the validity of this structure. The SSR Subscales were strongly related to the other state reactance measures. Moreover, the SSR Subscales showed modest positive correlations with trait measures of reactance. The SSR Subscales correlated only slightly or not at all with neighboring constructs (e.g., autonomy, experience of control). The only exception was fairness scales, which showed moderate correlations with the SSR Subscales. Furthermore, a retest analysis confirmed the temporal stability of the scale. Suggestions for further validation of this questionnaire are discussed.

  14. Scale modelling in LMFBR safety

    International Nuclear Information System (INIS)

    Cagliostro, D.J.; Florence, A.L.; Abrahamson, G.R.

    1979-01-01

    This paper reviews scale modelling techniques used in studying the structural response of LMFBR vessels to HCDA loads. The geometric, material, and dynamic similarity parameters are presented and identified using the methods of dimensional analysis. Complete similarity of the structural response requires that each similarity parameter be the same in the model as in the prototype. The paper then focuses on the methods, limitations, and problems of duplicating these parameters in scale models and mentions an experimental technique for verifying the scaling. Geometric similarity requires that all linear dimensions of the prototype be reduced in proportion to the ratio of a characteristic dimension of the model to that of the prototype. The overall size of the model depends on the structural detail required, the size of instrumentation, and the costs of machining and assemblying the model. Material similarity requires that the ratio of the density, bulk modulus, and constitutive relations for the structure and fluid be the same in the model as in the prototype. A practical choice of a material for the model is one with the same density and stress-strain relationship as the operating temperature. Ni-200 and water are good simulant materials for the 304 SS vessel and the liquid sodium coolant, respectively. Scaling of the strain rate sensitivity and fracture toughness of materials is very difficult, but may not be required if these effects do not influence the structural response of the reactor components. Dynamic similarity requires that the characteristic pressure of a simulant source equal that of the prototype HCDA for geometrically similar volume changes. The energy source is calibrated in the geometry and environment in which it will be used to assure that heat transfer between high temperature loading sources and the coolant simulant and that non-equilibrium effects in two-phase sources are accounted for. For the geometry and flow conitions of interest, the

  15. Scale dependence of deuteron electrodisintegration

    Science.gov (United States)

    More, S. N.; Bogner, S. K.; Furnstahl, R. J.

    2017-11-01

    Background: Isolating nuclear structure properties from knock-out reactions in a process-independent manner requires a controlled factorization, which is always to some degree scale and scheme dependent. Understanding this dependence is important for robust extractions from experiment, to correctly use the structure information in other processes, and to understand the impact of approximations for both. Purpose: We seek insight into scale dependence by exploring a model calculation of deuteron electrodisintegration, which provides a simple and clean theoretical laboratory. Methods: By considering various kinematic regions of the longitudinal structure function, we can examine how the components—the initial deuteron wave function, the current operator, and the final-state interactions (FSIs)—combine at different scales. We use the similarity renormalization group to evolve each component. Results: When evolved to different resolutions, the ingredients are all modified, but how they combine depends strongly on the kinematic region. In some regions, for example, the FSIs are largely unaffected by evolution, while elsewhere FSIs are greatly reduced. For certain kinematics, the impulse approximation at a high renormalization group resolution gives an intuitive picture in terms of a one-body current breaking up a short-range correlated neutron-proton pair, although FSIs distort this simple picture. With evolution to low resolution, however, the cross section is unchanged but a very different and arguably simpler intuitive picture emerges, with the evolved current efficiently represented at low momentum through derivative expansions or low-rank singular value decompositions. Conclusions: The underlying physics of deuteron electrodisintegration is scale dependent and not just kinematics dependent. As a result, intuition about physics such as the role of short-range correlations or D -state mixing in particular kinematic regimes can be strongly scale dependent

  16. Scaling Irrational Beliefs in the General Attitude and Belief Scale

    Directory of Open Access Journals (Sweden)

    Lindsay R. Owings

    2013-04-01

    Full Text Available Accurate measurement of key constructs is essential to the continued development of Rational-Emotive Behavior Therapy (REBT. The General Attitude and Belief Scale (GABS, a contemporary inventory of rational and irrational beliefs based on current REBT theory, is one of the most valid and widely used instruments available, and recent research has continued to improve its psychometric standing. In this study of 544 students, item response theory (IRT methods were used (a to identify the most informative item in each irrational subscale of the GABS, (b to determine the level of irrationality represented by each of those items, and (c to suggest a condensed form of the GABS for further study with clinical populations. Administering only the most psychometrically informative items to clients could result in economies of time and effort. Further research based on the scaling of items could clarify the specific patterns of irrational beliefs associated with particular clinical syndromes.

  17. Universal Scaling Relations in Scale-Free Structure Formation

    Science.gov (United States)

    Guszejnov, Dávid; Hopkins, Philip F.; Grudić, Michael Y.

    2018-04-01

    A large number of astronomical phenomena exhibit remarkably similar scaling relations. The most well-known of these is the mass distribution dN/dM∝M-2 which (to first order) describes stars, protostellar cores, clumps, giant molecular clouds, star clusters and even dark matter halos. In this paper we propose that this ubiquity is not a coincidence and that it is the generic result of scale-free structure formation where the different scales are uncorrelated. We show that all such systems produce a mass function proportional to M-2 and a column density distribution with a power law tail of dA/d lnΣ∝Σ-1. In the case where structure formation is controlled by gravity the two-point correlation becomes ξ2D∝R-1. Furthermore, structures formed by such processes (e.g. young star clusters, DM halos) tend to a ρ∝R-3 density profile. We compare these predictions with observations, analytical fragmentation cascade models, semi-analytical models of gravito-turbulent fragmentation and detailed "full physics" hydrodynamical simulations. We find that these power-laws are good first order descriptions in all cases.

  18. Frequency scaling for angle gathers

    KAUST Repository

    Zuberi, M. A H; Alkhalifah, Tariq Ali

    2014-01-01

    Angle gathers provide an extra dimension to analyze the velocity after migration. Space-shift and time shift-imaging conditions are two methods used to obtain angle gathers, but both are reasonably expensive. By scaling the time-lag axis of the time-shifted images, the computational cost of the time shift imaging condition can be considerably reduced. In imaging and more so Full waveform inversion, frequencydomain Helmholtz solvers are used more often to solve for the wavefields than conventional time domain extrapolators. In such cases, we do not need to extend the image, instead we scale the frequency axis of the frequency domain image to obtain the angle gathers more efficiently. Application on synthetic data demonstrate such features.

  19. Scaling in public transport networks

    Directory of Open Access Journals (Sweden)

    C. von Ferber

    2005-01-01

    Full Text Available We analyse the statistical properties of public transport networks. These networks are defined by a set of public transport routes (bus lines and the stations serviced by these. For larger networks these appear to possess a scale-free structure, as it is demonstrated e.g. by the Zipf law distribution of the number of routes servicing a given station or for the distribution of the number of stations which can be visited from a chosen one without changing the means of transport. Moreover, a rather particular feature of the public transport network is that many routes service common subsets of stations. We discuss the possibility of new scaling laws that govern intrinsic properties of such subsets.

  20. Holographic models with anisotropic scaling

    Science.gov (United States)

    Brynjolfsson, E. J.; Danielsson, U. H.; Thorlacius, L.; Zingg, T.

    2013-12-01

    We consider gravity duals to d+1 dimensional quantum critical points with anisotropic scaling. The primary motivation comes from strongly correlated electron systems in condensed matter theory but the main focus of the present paper is on the gravity models in their own right. Physics at finite temperature and fixed charge density is described in terms of charged black branes. Some exact solutions are known and can be used to obtain a maximally extended spacetime geometry, which has a null curvature singularity inside a single non-degenerate horizon, but generic black brane solutions in the model can only be obtained numerically. Charged matter gives rise to black branes with hair that are dual to the superconducting phase of a holographic superconductor. Our numerical results indicate that holographic superconductors with anisotropic scaling have vanishing zero temperature entropy when the back reaction of the hair on the brane geometry is taken into account.

  1. Scaling laws for specialized hohlraums

    International Nuclear Information System (INIS)

    Rosen, M.D.

    1993-01-01

    The author presents scaling laws for the behavior of hohlraums that are somewhat more complex than a simple sphere or cylinder. In particular the author considers hohlraums that are in what has become known as a open-quotes primaryclose quotes open-quotes secondaryclose quotes configuration, namely geometries in which the laser is absorbed in a primary region of a hohlraum, and only radiation energy is transported to a secondary part of the hohlraum that is shielded from seeing the laser light directly. Such hohlraums have been in use of late for doing LTE opacity experiments on a sample in the secondary and in recently proposed open-quotes shimmedclose quotes hohlraums that use gold disks on axis to block a capsule's view of the cold laser entrance hole. The temperature/drive of the secondary, derived herein, scales somewhat differently than the drive in simple hohlraums

  2. Applied multidimensional scaling and unfolding

    CERN Document Server

    Borg, Ingwer; Mair, Patrick

    2018-01-01

    This book introduces multidimensional scaling (MDS) and unfolding as data analysis techniques for applied researchers. MDS is used for the analysis of proximity data on a set of objects, representing the data as distances between points in a geometric space (usually of two dimensions). Unfolding is a related method that maps preference data (typically evaluative ratings of different persons on a set of objects) as distances between two sets of points (representing the persons and the objects, resp.). This second edition has been completely revised to reflect new developments and the coverage of unfolding has also been substantially expanded. Intended for applied researchers whose main interests are in using these methods as tools for building substantive theories, it discusses numerous applications (classical and recent), highlights practical issues (such as evaluating model fit), presents ways to enforce theoretical expectations for the scaling solutions, and addresses the typical mistakes that MDS/unfoldin...

  3. Heavy quark hadron mass scale

    International Nuclear Information System (INIS)

    Anderson, J.T.

    1994-01-01

    Without the spin interactions the hardron masses within a multiplet are degenerate. The light quark hadron degenerate mulitplet mass spectrum is extended from the 3 quark ground state multiplets at J P =0 - , 1/2 + , 1 - to include the excited states which follow the spinorial decomposition of SU(2)xSU(2). The mass scales for the 4, 5, 6, .. quark hadrons are obtained from the degenerate multiplet mass m 0 /M=n 2 /α with n=4, 5, 6, .. The 4, 5, 6, .. quark hadron degenerate multiplet masses follow by splitting of the heavy quark mass scales according to the spinorial decomposition of SU(2)xSU(2). (orig.)

  4. Impedance Scaling and Impedance Control

    International Nuclear Information System (INIS)

    Chou, W.; Griffin, J.

    1997-06-01

    When a machine becomes really large, such as the Very Large Hadron Collider (VLHC), of which the circumference could reach the order of megameters, beam instability could be an essential bottleneck. This paper studies the scaling of the instability threshold vs. machine size when the coupling impedance scales in a ''normal'' way. It is shown that the beam would be intrinsically unstable for the VLHC. As a possible solution to this problem, it is proposed to introduce local impedance inserts for controlling the machine impedance. In the longitudinal plane, this could be done by using a heavily detuned rf cavity (e.g., a biconical structure), which could provide large imaginary impedance with the right sign (i.e., inductive or capacitive) while keeping the real part small. In the transverse direction, a carefully designed variation of the cross section of a beam pipe could generate negative impedance that would partially compensate the transverse impedance in one plane

  5. THE MODERN RACISM SCALE: PSYCHOMETRIC

    Directory of Open Access Journals (Sweden)

    MANUEL CÁRDENAS

    2007-08-01

    Full Text Available An adaption of McConahay, Harder and Batts’ (1981 moderm racism scale is presented for Chilean population andits psychometric properties, (reliability and validity are studied, along with its relationship with other relevantpsychosocial variables in studies on prejudice and ethnic discrimination (authoritarianism, religiousness, politicalposition, etc., as well as with other forms of prejudice (gender stereotypes and homophobia. The sample consistedof 120 participants, students of psychology, resident in the city of Antofagasta (a geographical zone with a highnumber of Latin-American inmigrants. Our findings show that the scale seems to be a reliable instrument to measurethe prejudice towards Bolivian immigrants in our social environment. Likewise, important differences among thesubjects are detected with high and low scores in the psychosocial variables used.

  6. Global scale groundwater flow model

    Science.gov (United States)

    Sutanudjaja, Edwin; de Graaf, Inge; van Beek, Ludovicus; Bierkens, Marc

    2013-04-01

    As the world's largest accessible source of freshwater, groundwater plays vital role in satisfying the basic needs of human society. It serves as a primary source of drinking water and supplies water for agricultural and industrial activities. During times of drought, groundwater sustains water flows in streams, rivers, lakes and wetlands, and thus supports ecosystem habitat and biodiversity, while its large natural storage provides a buffer against water shortages. Yet, the current generation of global scale hydrological models does not include a groundwater flow component that is a crucial part of the hydrological cycle and allows the simulation of groundwater head dynamics. In this study we present a steady-state MODFLOW (McDonald and Harbaugh, 1988) groundwater model on the global scale at 5 arc-minutes resolution. Aquifer schematization and properties of this groundwater model were developed from available global lithological model (e.g. Dürr et al., 2005; Gleeson et al., 2010; Hartmann and Moorsdorff, in press). We force the groundwtaer model with the output from the large-scale hydrological model PCR-GLOBWB (van Beek et al., 2011), specifically the long term net groundwater recharge and average surface water levels derived from routed channel discharge. We validated calculated groundwater heads and depths with available head observations, from different regions, including the North and South America and Western Europe. Our results show that it is feasible to build a relatively simple global scale groundwater model using existing information, and estimate water table depths within acceptable accuracy in many parts of the world.

  7. Cosmological origin of mass scales

    International Nuclear Information System (INIS)

    Terazawa, H.

    1981-01-01

    We discuss the possibility that spontaneous breakdown of conformal invariance due to the very existence of our universe originates all the mass (or length) scales ranging from the Planck mass (approx. 10 19 GeV) to the Hubble constant (approx. 10 -42 GeV) and suggest that the photon may have a curvature-dependent mass which is as small as 10 -42 GeV. We also present a possible clue to Dirac's large number hypothesis. (orig.)

  8. Cosmological origin of mass scales

    International Nuclear Information System (INIS)

    Terazawa, Hidezumi.

    1981-02-01

    We discuss the possibility that spontaneous breakdown of conformal invariance due to the very existence of our universe originates all the mass (or length) scales ranging from the Planck mass (--10 19 GeV) to the Hubble constant (--10 -42 GeV) and suggest that the photon may have a curvature-dependent mass which is as small as 10 -42 GeV. We also present a possible clue to the Dirac's large number hypothesis. (author)

  9. Large-scale solar heat

    Energy Technology Data Exchange (ETDEWEB)

    Tolonen, J.; Konttinen, P.; Lund, P. [Helsinki Univ. of Technology, Otaniemi (Finland). Dept. of Engineering Physics and Mathematics

    1998-12-31

    In this project a large domestic solar heating system was built and a solar district heating system was modelled and simulated. Objectives were to improve the performance and reduce costs of a large-scale solar heating system. As a result of the project the benefit/cost ratio can be increased by 40 % through dimensioning and optimising the system at the designing stage. (orig.)

  10. Source Code Analysis Laboratory (SCALe)

    Science.gov (United States)

    2012-04-01

    products (including services) and processes. The agency has also published ISO / IEC 17025 :2005 General Requirements for the Competence of Testing...SCALe undertakes. Testing and calibration laboratories that comply with ISO / IEC 17025 also operate in accordance with ISO 9001. • NIST National...assessed by the accreditation body against all of the requirements of ISO / IEC 17025 : 2005 General requirements for the competence of testing and

  11. Scaling Exponents in Financial Markets

    Science.gov (United States)

    Kim, Kyungsik; Kim, Cheol-Hyun; Kim, Soo Yong

    2007-03-01

    We study the dynamical behavior of four exchange rates in foreign exchange markets. A detrended fluctuation analysis (DFA) is applied to detect the long-range correlation embedded in the non-stationary time series. It is for our case found that there exists a persistent long-range correlation in volatilities, which implies the deviation from the efficient market hypothesis. Particularly, the crossover is shown to exist in the scaling behaviors of the volatilities.

  12. Recent developments in complex scaling

    International Nuclear Information System (INIS)

    Rescigno, T.N.

    1980-01-01

    Some recent developments in the use of complex basis function techniques to study resonance as well as certain types of non-resonant, scattering phenomena are discussed. Complex scaling techniques and other closely related methods have continued to attract the attention of computational physicists and chemists and have now reached a point of development where meaningful calculations on many-electron atoms and molecules are beginning to appear feasible

  13. Turbulence Intensity Scaling: A Fugue

    OpenAIRE

    Basse, Nils T.

    2018-01-01

    We study streamwise turbulence intensity definitions using smooth- and rough-wall pipe flow measurements made in the Princeton Superpipe. Scaling of turbulence intensity with the bulk (and friction) Reynolds number is provided for the definitions. The turbulence intensity is proportional to the square root of the friction factor with the same proportionality constant for smooth- and rough-wall pipe flow. Turbulence intensity definitions providing the best description of the measurements are i...

  14. Transition physics and scaling overview

    International Nuclear Information System (INIS)

    Carlstrom, T.N.

    1996-01-01

    This paper presents an overview of recent experimental progress towards understanding H-mode transition physics and scaling. Terminology and techniques for studying H-mode are reviewed and discussed. The model of shear E x B flow stabilization of edge fluctuations at the L-H transition is gaining wide acceptance and is further supported by observations of edge rotation on a number of new devices. Observations of poloidal asymmetries of edge fluctuations and dephasing of density and potential fluctuations after the transition pose interesting challenges for understanding H-mode physics. Dedicated scans to determine the scaling of the power threshold have now been performed on many machines. A clear B t dependence is universally observed but dependence on the line averaged density is complicated. Other dependencies are also reported. Studies of the effect of neutrals and error fields on the power threshold are under investigation. The ITER threshold database has matured and offers guidance to the power threshold scaling issues relevant to next-step devices. (author)

  15. A laboratory scale fundamental time?

    International Nuclear Information System (INIS)

    Mendes, R.V.

    2012-01-01

    The existence of a fundamental time (or fundamental length) has been conjectured in many contexts. However, the ''stability of physical theories principle'' seems to be the one that provides, through the tools of algebraic deformation theory, an unambiguous derivation of the stable structures that Nature might have chosen for its algebraic framework. It is well-known that c and ℎ are the deformation parameters that stabilize the Galilean and the Poisson algebra. When the stability principle is applied to the Poincare-Heisenberg algebra, two deformation parameters emerge which define two time (or length) scales. In addition there are, for each of them, a plus or minus sign possibility in the relevant commutators. One of the deformation length scales, related to non-commutativity of momenta, is probably related to the Planck length scale but the other might be much larger and already detectable in laboratory experiments. In this paper, this is used as a working hypothesis to look for physical effects that might settle this question. Phase-space modifications, resonances, interference, electron spin resonance and non-commutative QED are considered. (orig.)

  16. Large scale cluster computing workshop

    International Nuclear Information System (INIS)

    Dane Skow; Alan Silverman

    2002-01-01

    Recent revolutions in computer hardware and software technologies have paved the way for the large-scale deployment of clusters of commodity computers to address problems heretofore the domain of tightly coupled SMP processors. Near term projects within High Energy Physics and other computing communities will deploy clusters of scale 1000s of processors and be used by 100s to 1000s of independent users. This will expand the reach in both dimensions by an order of magnitude from the current successful production facilities. The goals of this workshop were: (1) to determine what tools exist which can scale up to the cluster sizes foreseen for the next generation of HENP experiments (several thousand nodes) and by implication to identify areas where some investment of money or effort is likely to be needed. (2) To compare and record experimences gained with such tools. (3) To produce a practical guide to all stages of planning, installing, building and operating a large computing cluster in HENP. (4) To identify and connect groups with similar interest within HENP and the larger clustering community

  17. Dimensional scaling for quasistationary states

    International Nuclear Information System (INIS)

    Kais, S.; Herschbach, D.R.

    1993-01-01

    Complex energy eigenvalues which specify the location and width of quasibound or resonant states are computed to good approximation by a simple dimensional scaling method. As applied to bound states, the method involves minimizing an effective potential function in appropriately scaled coordinates to obtain exact energies in the D→∞ limit, then computing approximate results for D=3 by a perturbation expansion in 1/D about this limit. For resonant states, the same procedure is used, with the radial coordinate now allowed to be complex. Five examples are treated: the repulsive exponential potential (e - r); a squelched harmonic oscillator (r 2 e - r); the inverted Kratzer potential (r -1 repulsion plus r -2 attraction); the Lennard-Jones potential (r -12 repulsion, r -6 attraction); and quasibound states for the rotational spectrum of the hydrogen molecule (X 1 summation g + , v=0, J=0 to 50). Comparisons with numerical integrations and other methods show that the much simpler dimensional scaling method, carried to second-order (terms in 1/D 2 ), yields good results over an extremely wide range of the ratio of level widths to spacings. Other methods have not yet evaluated the very broad H 2 rotational resonances reported here (J>39), which lie far above the centrifugal barrier

  18. Transition physics and scaling overview

    International Nuclear Information System (INIS)

    Carlstrom, T.N.

    1995-12-01

    This paper presents an overview of recent experimental progress towards understanding H-mode transition physics and scaling. Terminology and techniques for studying H-mode are reviewed and discussed. The model of shear E x B flow stabilization of edge fluctuations at the L-H transition is gaining wide acceptance and is further supported by observations of edge rotation on a number of new devices. Observations of poloidal asymmetries of edge fluctuations and dephasing of density and potential fluctuations after the transition pose interesting challenges for understanding H-mode physics. Dedicated scans to determine the scaling of the power threshold have now been performed on many machines. A dear B t dependence is universally observed but dependence on the line averaged density is complicated. Other dependencies are also reported. Studies of the effect of neutrals and error fields on the power threshold are under investigation. The ITER threshold database has matured and offers guidance to the power threshold scaling issues relevant to next-step devices

  19. The Principle of Social Scaling

    Directory of Open Access Journals (Sweden)

    Paulo L. dos Santos

    2017-01-01

    Full Text Available This paper identifies a general class of economic processes capable of generating the first-moment constraints implicit in the observed cross-sectional distributions of a number of economic variables: processes of social scaling. Across a variety of settings, the outcomes of economic competition reflect the normalization of individual values of certain economic quantities by average or social measures of themselves. The resulting socioreferential processes establish systematic interdependences among individual values of important economic variables, which under certain conditions take the form of emergent first-moment constraints on their distributions. The paper postulates a principle describing this systemic regulation of socially scaled variables and illustrates its empirical purchase by showing how capital- and labor-market competition can give rise to patterns of social scaling that help account for the observed distributions of Tobin’s q and wage income. The paper’s discussion embodies a distinctive approach to understanding and investigating empirically the relationship between individual agency and structural determinations in complex economic systems and motivates the development of observational foundations for aggregative, macrolevel economic analysis.

  20. Large scale cross hole testing

    International Nuclear Information System (INIS)

    Ball, J.K.; Black, J.H.; Doe, T.

    1991-05-01

    As part of the Site Characterisation and Validation programme the results of the large scale cross hole testing have been used to document hydraulic connections across the SCV block, to test conceptual models of fracture zones and obtain hydrogeological properties of the major hydrogeological features. The SCV block is highly heterogeneous. This heterogeneity is not smoothed out even over scales of hundreds of meters. Results of the interpretation validate the hypothesis of the major fracture zones, A, B and H; not much evidence of minor fracture zones is found. The uncertainty in the flow path, through the fractured rock, causes sever problems in interpretation. Derived values of hydraulic conductivity were found to be in a narrow range of two to three orders of magnitude. Test design did not allow fracture zones to be tested individually. This could be improved by testing the high hydraulic conductivity regions specifically. The Piezomac and single hole equipment worked well. Few, if any, of the tests ran long enough to approach equilibrium. Many observation boreholes showed no response. This could either be because there is no hydraulic connection, or there is a connection but a response is not seen within the time scale of the pumping test. The fractional dimension analysis yielded credible results, and the sinusoidal testing procedure provided an effective means of identifying the dominant hydraulic connections. (10 refs.) (au)

  1. Development of emotional stability scale

    Directory of Open Access Journals (Sweden)

    M Chaturvedi

    2010-01-01

    Full Text Available Background: Emotional stability remains the central theme in personality studies. The concept of stable emotional behavior at any level is that which reflects the fruits of normal emotional development. The study aims at development of an emotional stability scale. Materials and Methods: Based on available literature the components of emotional stability were identified and 250 items were developed, covering each component. Two-stage elimination of items was carried out, i.e. through judges′ opinions and item analysis. Results: Fifty items with highest ′t′ values covering 5 dimensions of emotional stability viz pessimism vs. optimism, anxiety vs. calm, aggression vs. tolerance., dependence vs. autonomy., apathy vs. empathy were retained in the final scale. Reliability as checked by Cronbach′s alpha was .81 and by split half method it was .79. Content validity and construct validity were checked. Norms are given in the form of cumulative percentages. Conclusion: Based on the psychometric principles a 50 item, self-administered 5 point Lickert type rating scale was developed for measurement of emotional stability.

  2. Interest in Aesthetic Rhinoplasty Scale.

    Science.gov (United States)

    Naraghi, Mohsen; Atari, Mohammad

    2017-04-01

    Interest in cosmetic surgery is increasing, with rhinoplasty being one of the most popular surgical procedures. It is essential that surgeons identify patients with existing psychological conditions before any procedure. This study aimed to develop and validate the Interest in Aesthetic Rhinoplasty Scale (IARS). Four studies were conducted to develop the IARS and to evaluate different indices of validity (face, content, construct, criterion, and concurrent validities) and reliability (internal consistency, split-half coefficient, and temporal stability) of the scale. The four study samples included a total of 463 participants. Statistical analysis revealed satisfactory psychometric properties in all samples. Scores on the IARS were negatively correlated with self-esteem scores ( r  = -0.296; p  social dysfunction ( r  = 0.268; p  < 0.01), and depression ( r  = 0.308; p  < 0.01). The internal and test-retest coefficients of consistency were found to be high (α = 0.93; intraclass coefficient = 0.94). Rhinoplasty patients were found to have significantly higher IARS scores than nonpatients ( p  < 0.001). Findings of the present studies provided evidence for face, content, construct, criterion, and concurrent validities and internal and test-retest reliability of the IARS. This evidence supports the use of the scale in clinical and research settings. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  3. Temporal scaling in information propagation

    Science.gov (United States)

    Huang, Junming; Li, Chao; Wang, Wen-Qiang; Shen, Hua-Wei; Li, Guojie; Cheng, Xue-Qi

    2014-06-01

    For the study of information propagation, one fundamental problem is uncovering universal laws governing the dynamics of information propagation. This problem, from the microscopic perspective, is formulated as estimating the propagation probability that a piece of information propagates from one individual to another. Such a propagation probability generally depends on two major classes of factors: the intrinsic attractiveness of information and the interactions between individuals. Despite the fact that the temporal effect of attractiveness is widely studied, temporal laws underlying individual interactions remain unclear, causing inaccurate prediction of information propagation on evolving social networks. In this report, we empirically study the dynamics of information propagation, using the dataset from a population-scale social media website. We discover a temporal scaling in information propagation: the probability a message propagates between two individuals decays with the length of time latency since their latest interaction, obeying a power-law rule. Leveraging the scaling law, we further propose a temporal model to estimate future propagation probabilities between individuals, reducing the error rate of information propagation prediction from 6.7% to 2.6% and improving viral marketing with 9.7% incremental customers.

  4. Scale-invariant gravity: geometrodynamics

    International Nuclear Information System (INIS)

    Anderson, Edward; Barbour, Julian; Foster, Brendan; Murchadha, Niall O

    2003-01-01

    We present a scale-invariant theory, conformal gravity, which closely resembles the geometrodynamical formulation of general relativity (GR). While previous attempts to create scale-invariant theories of gravity have been based on Weyl's idea of a compensating field, our direct approach dispenses with this and is built by extension of the method of best matching w.r.t. scaling developed in the parallel particle dynamics paper by one of the authors. In spatially compact GR, there is an infinity of degrees of freedom that describe the shape of 3-space which interact with a single volume degree of freedom. In conformal gravity, the shape degrees of freedom remain, but the volume is no longer a dynamical variable. Further theories and formulations related to GR and conformal gravity are presented. Conformal gravity is successfully coupled to scalars and the gauge fields of nature. It should describe the solar system observations as well as GR does, but its cosmology and quantization will be completely different

  5. Statistical and Judgmental Criteria for Scale Purification

    DEFF Research Database (Denmark)

    Wieland, Andreas; Durach, Christian F.; Kembro, Joakim

    2017-01-01

    of scale purification, to critically analyze the current state of scale purification in supply chain management (SCM) research and to provide suggestions for advancing the scale-purification process. Design/methodology/approach A framework for making scale-purification decisions is developed and used...

  6. Scaling properties of foreign exchange volatility

    NARCIS (Netherlands)

    Gençay, R.; Selçuk, F.; Whitcher, B.

    2001-01-01

    In this paper, we investigate the scaling properties of foreign exchange volatility. Our methodology is based on a wavelet multi-scaling approach which decomposes the variance of a time series and the covariance between two time series on a scale by scale basis through the application of a discrete

  7. Evaluating the impact of farm scale innovation at catchment scale

    Science.gov (United States)

    van Breda, Phelia; De Clercq, Willem; Vlok, Pieter; Querner, Erik

    2014-05-01

    Hydrological modelling lends itself to other disciplines very well, normally as a process based system that acts as a catalogue of events taking place. These hydrological models are spatial-temporal in their design and are generally well suited for what-if situations in other disciplines. Scaling should therefore be a function of the purpose of the modelling. Process is always linked with scale or support but the temporal resolution can affect the results if the spatial scale is not suitable. The use of hydrological response units tends to lump area around physical features but disregards farm boundaries. Farm boundaries are often the more crucial uppermost resolution needed to gain more value from hydrological modelling. In the Letaba Catchment of South Africa, we find a generous portion of landuses, different models of ownership, different farming systems ranging from large commercial farms to small subsistence farming. All of these have the same basic right to water but water distribution in the catchment is somewhat of a problem. Since water quantity is also a problem, the water supply systems need to take into account that valuable production areas not be left without water. Clearly hydrological modelling should therefore be sensitive to specific landuse. As a measure of productivity, a system of small farmer production evaluation was designed. This activity presents a dynamic system outside hydrological modelling that is generally not being considered inside hydrological modelling but depends on hydrological modelling. For sustainable development, a number of important concepts needed to be aligned with activities in this region, and the regulatory actions also need to be adhered to. This study aimed at aligning the activities in a region to the vision and objectives of the regulatory authorities. South Africa's system of socio-economic development planning is complex and mostly ineffective. There are many regulatory authorities involved, often with unclear

  8. Development of a Facebook Addiction Scale.

    Science.gov (United States)

    Andreassen, Cecilie Schou; Torsheim, Torbjørn; Brunborg, Geir Scott; Pallesen, Ståle

    2012-04-01

    The Bergen Facebook Addiction Scale (BFAS), initially a pool of 18 items, three reflecting each of the six core elements of addiction (salience, mood modification, tolerance, withdrawal, conflict, and relapse), was constructed and administered to 423 students together with several other standardized self-report scales (Addictive Tendencies Scale, Online Sociability Scale, Facebook Attitude Scale, NEO-FFI, BIS/BAS scales, and Sleep questions). That item within each of the six addiction elements with the highest corrected item-total correlation was retained in the final scale. The factor structure of the scale was good (RMSEA = .046, CFI = .99) and coefficient alpha was .83. The 3-week test-retest reliability coefficient was .82. The scores converged with scores for other scales of Facebook activity. Also, they were positively related to Neuroticism and Extraversion, and negatively related to Conscientiousness. High scores on the new scale were associated with delayed bedtimes and rising times.

  9. Normal tissue damage in radiotherapy development of a clinical audit tool

    International Nuclear Information System (INIS)

    Barrett, A.

    2001-01-01

    Radiotherapy treatments are evaluated by two main outcomes, rates of cure or local tumour control and normal tissue complication rates. Many excellent schemes have been devised for recording the late effects of radiotherapy treatments including the RTOG and LENT SOMA Scales. These have proved invaluable in documenting the outcome of clinical trials, but have proved too complex and time consuming for routine daily use in busy departments. A group in Eindhoven led by Professor Lybeert undertook a pilot study of a potential way of auditing late radiation complications. Using a simplified form derived from the LENT SOMA scales, they collected data on grade 3 and 4 complications in a total of 675 patients and were able to correlate a number of particular complications with specific protocols, ICD codes and physician practice. Further review of the case records made it possible to identify specific factors which may have led to toxicity and could be taken into account to modify treatment protocols. From September 1999 clinicians in participating centres undertaking normal follow-up procedures were asked to identify patients who showed evidence of grade 3 or 4 toxicity as defined in the pro-forma. Date of radiotherapy was recorded so that a temporal correlation of complication with treatment could be made, but this study did not attempt to assess the incidence of complications, but to provide a cross-sectional study of prevalence. Centres participating in the study have been Eindhoven, Koeln, Gent, Brussels, Glasgow, Mount Vernon, Madrid, Geneva and Lyon. In Eindhoven 651 reports were collected between January 1995 and December 1999. 89 reports had to be discarded because complications were not validated by the reviewing radiotherapists. Dr Lybeert noticed that individual radiotherapists appeared to have different thresholds for reporting specific complications. 13 patients deaths appeared to be related to radiation problems. An overall level of detection of morbidity was

  10. The Origin of Scales and Scaling Laws in Star Formation

    Science.gov (United States)

    Guszejnov, David; Hopkins, Philip; Grudich, Michael

    2018-01-01

    Star formation is one of the key processes of cosmic evolution as it influences phenomena from the formation of galaxies to the formation of planets, and the development of life. Unfortunately, there is no comprehensive theory of star formation, despite intense effort on both the theoretical and observational sides, due to the large amount of complicated, non-linear physics involved (e.g. MHD, gravity, radiation). A possible approach is to formulate simple, easily testable models that allow us to draw a clear connection between phenomena and physical processes.In the first part of the talk I will focus on the origin of the IMF peak, the characteristic scale of stars. There is debate in the literature about whether the initial conditions of isothermal turbulence could set the IMF peak. Using detailed numerical simulations, I will demonstrate that not to be the case, the initial conditions are "forgotten" through the fragmentation cascade. Additional physics (e.g. feedback) is required to set the IMF peak.In the second part I will use simulated galaxies from the Feedback in Realistic Environments (FIRE) project to show that most star formation theories are unable to reproduce the near universal IMF peak of the Milky Way.Finally, I will present analytic arguments (supported by simulations) that a large number of observables (e.g. IMF slope) are the consequences of scale-free structure formation and are (to first order) unsuitable for differentiating between star formation theories.

  11. A scale invariance criterion for LES parametrizations

    Directory of Open Access Journals (Sweden)

    Urs Schaefer-Rolffs

    2015-01-01

    Full Text Available Turbulent kinetic energy cascades in fluid dynamical systems are usually characterized by scale invariance. However, representations of subgrid scales in large eddy simulations do not necessarily fulfill this constraint. So far, scale invariance has been considered in the context of isotropic, incompressible, and three-dimensional turbulence. In the present paper, the theory is extended to compressible flows that obey the hydrostatic approximation, as well as to corresponding subgrid-scale parametrizations. A criterion is presented to check if the symmetries of the governing equations are correctly translated into the equations used in numerical models. By applying scaling transformations to the model equations, relations between the scaling factors are obtained by demanding that the mathematical structure of the equations does not change.The criterion is validated by recovering the breakdown of scale invariance in the classical Smagorinsky model and confirming scale invariance for the Dynamic Smagorinsky Model. The criterion also shows that the compressible continuity equation is intrinsically scale-invariant. The criterion also proves that a scale-invariant turbulent kinetic energy equation or a scale-invariant equation of motion for a passive tracer is obtained only with a dynamic mixing length. For large-scale atmospheric flows governed by the hydrostatic balance the energy cascade is due to horizontal advection and the vertical length scale exhibits a scaling behaviour that is different from that derived for horizontal length scales.

  12. Proposing a tornado watch scale

    Science.gov (United States)

    Mason, Jonathan Brock

    This thesis provides an overview of language used in tornado safety recommendations from various sources, along with developing a rubric for scaled tornado safety recommendations, and subsequent development and testing of a tornado watch scale. The rubric is used to evaluate tornado refuge/shelter adequacy responses of Tuscaloosa residents gathered following the April 27, 2011 Tuscaloosa, Alabama EF4 tornado. There was a significant difference in the counts of refuge adequacy for Tuscaloosa residents when holding the locations during the April 27th tornado constant and comparing adequacy ratings for weak (EF0-EF1), strong (EF2-EF3) and violent (EF4-EF5) tornadoes. There was also a significant difference when comparing future tornado refuge plans of those same participants to the adequacy ratings for weak, strong and violent tornadoes. The tornado refuge rubric is then revised into a six-class, hierarchical Tornado Watch Scale (TWS) from Level 0 to Level 5 based on the likelihood of high-impact or low-impact severe weather events containing weak, strong or violent tornadoes. These levels represent maximum expected tornado intensity and include tornado safety recommendations from the tornado refuge rubric. Audio recordings similar to those used in current National Oceanic and Atmospheric Administration (NOAA) weather radio communications were developed to correspond to three levels of the TWS, a current Storm Prediction Center (SPC) tornado watch and a particularly dangerous situation (PDS) tornado watch. These were then used in interviews of Alabama residents to determine how changes to the information contained in the watch statements would affect each participant's tornado safety actions and perception of event danger. Results from interview participants (n=38) indicate a strong preference (97.37%) for the TWS when compared to current tornado watch and PDS tornado watch statements. Results also show the TWS elicits more adequate safety decisions from participants

  13. NSLINK: NJOY-SCALE-LINK

    International Nuclear Information System (INIS)

    Leege, P.F.A. de

    1991-05-01

    NSLINK is a set of computer codes to couple the NJOY cross-section generation code to the SCALE-3 code system (using AMPX-2 master library format) retaining the Nordheim resolved resonance treatment option. The following codes are included in NSLINK: XLACSR, a stripped-down version of the XLACS-2 code; MILER, converts NJOY output (GENDF format) to AMPX-2 master format; UNITABR, a revised version of the UNITAB code; BONAMI, in order to take into account the combination of Bondarenko and Nordheim resonance treatment, certain subroutines are included in the package which replace some subroutines in the BONAMI code. (author). 6 refs., 1 fig

  14. Water flow at all scales

    DEFF Research Database (Denmark)

    Sand-Jensen, K.

    2006-01-01

    Continuous water fl ow is a unique feature of streams and distinguishes them from all other ecosystems. The main fl ow is always downstream but it varies in time and space and can be diffi cult to measure and describe. The interest of hydrologists, geologists, biologists and farmers in water fl ow......, and its physical impact, depends on whether the main focus is on the entire stream system, the adjacent fi elds, the individual reaches or the habitats of different species. It is important to learn how to manage fl ow at all scales, in order to understand the ecology of streams and the biology...

  15. Accentuation-suppression and scaling

    DEFF Research Database (Denmark)

    Sørensen, Thomas Alrik; Bundesen, Claus

    2012-01-01

    The limitations of the visual short-term memory (VSTM) system have become an increasingly popular field of study. One line of inquiry has focused on the way attention selects objects for encoding into VSTM. Using the framework of the Theory of Visual Attention (TVA; Bundesen, 1990 Psychological...... a scaling mechanism modulating the decision bias of the observer and also through an accentuation-suppression mechanism that modulates the degree of subjective relevance of objects, contracting attention around fewer, highly relevant objects while suppressing less relevant objects. These mechanisms may...

  16. The Scales of Gravitational Lensing

    Directory of Open Access Journals (Sweden)

    Francesco De Paolis

    2016-03-01

    Full Text Available After exactly a century since the formulation of the general theory of relativity, the phenomenon of gravitational lensing is still an extremely powerful method for investigating in astrophysics and cosmology. Indeed, it is adopted to study the distribution of the stellar component in the Milky Way, to study dark matter and dark energy on very large scales and even to discover exoplanets. Moreover, thanks to technological developments, it will allow the measure of the physical parameters (mass, angular momentum and electric charge of supermassive black holes in the center of ours and nearby galaxies.

  17. JavaScript at scale

    CERN Document Server

    Boduch, Adam

    2015-01-01

    Have you ever come up against an application that felt like it was built on sand? Maybe you've been tasked with creating an application that needs to last longer than a year before a complete re-write? If so, JavaScript at Scale is your missing documentation for maintaining scalable architectures. There's no prerequisite framework knowledge required for this book, however, most concepts presented throughout are adaptations of components found in frameworks such as Backbone, AngularJS, or Ember. All code examples are presented using ECMAScript 6 syntax, to make sure your applications are ready

  18. Scaling law in laboratory astrophysics

    International Nuclear Information System (INIS)

    Xia Jiangfan; Zhang Jie

    2001-01-01

    The use of state-of-the-art lasers makes it possible to produce, in the laboratory, the extreme conditions similar to those in astrophysical processes. The introduction of astrophysics-relevant ideas in laser-plasma interaction experiments is propitious to the understanding of astrophysical phenomena. However, the great difference between laser-produced plasma and astrophysical objects makes it awkward to model the latter by laser-plasma experiments. The author presents the physical reasons for modeling astrophysical plasmas by laser plasmas, connecting these two kinds of plasmas by scaling laws. This allows the creation of experimental test beds where observation and models can be quantitatively compared with laboratory data

  19. Outer scale of atmospheric turbulence

    Science.gov (United States)

    Lukin, Vladimir P.

    2005-10-01

    In the early 70's, the scientists in Italy (A.Consortini, M.Bertolotti, L.Ronchi), USA (R.Buser, Ochs, S.Clifford) and USSR (V.Pokasov, V.Lukin) almost simultaneously discovered the phenomenon of deviation from the power law and the effect of saturation for the structure phase function. During a period of 35 years we have performed successively the investigations of the effect of low-frequency spectral range of atmospheric turbulence on the optical characteristics. The influence of the turbulence models as well as a outer scale of turbulence on the characteristics of telescopes and systems of laser beam formations has been determined too.

  20. Scaling of interfacial jump conditions

    International Nuclear Information System (INIS)

    Quezada G, S.; Vazquez R, A.; Espinosa P, G.

    2015-09-01

    To model the behavior of a nuclear reactor accurately is needed to have balance models that take into account the different phenomena occurring in the reactor. These balances have to be coupled together through boundary conditions. The boundary conditions have been studied and different treatments have been given to the interface. In this paper is a brief description of some of the interfacial jump conditions that have been proposed in recent years. Also, the scaling of an interfacial jump condition is proposed, for coupling the different materials that are in contact within a nuclear reactor. (Author)

  1. Drift-Scale Radionuclide Transport

    International Nuclear Information System (INIS)

    Houseworth, J.

    2004-01-01

    The purpose of this model report is to document the drift scale radionuclide transport model, taking into account the effects of emplacement drifts on flow and transport in the vicinity of the drift, which are not captured in the mountain-scale unsaturated zone (UZ) flow and transport models ''UZ Flow Models and Submodels'' (BSC 2004 [DIRS 169861]), ''Radionuclide Transport Models Under Ambient Conditions'' (BSC 2004 [DIRS 164500]), and ''Particle Tracking Model and Abstraction of Transport Process'' (BSC 2004 [DIRS 170041]). The drift scale radionuclide transport model is intended to be used as an alternative model for comparison with the engineered barrier system (EBS) radionuclide transport model ''EBS Radionuclide Transport Abstraction'' (BSC 2004 [DIRS 169868]). For that purpose, two alternative models have been developed for drift-scale radionuclide transport. One of the alternative models is a dual continuum flow and transport model called the drift shadow model. The effects of variations in the flow field and fracture-matrix interaction in the vicinity of a waste emplacement drift are investigated through sensitivity studies using the drift shadow model (Houseworth et al. 2003 [DIRS 164394]). In this model, the flow is significantly perturbed (reduced) beneath the waste emplacement drifts. However, comparisons of transport in this perturbed flow field with transport in an unperturbed flow field show similar results if the transport is initiated in the rock matrix. This has led to a second alternative model, called the fracture-matrix partitioning model, that focuses on the partitioning of radionuclide transport between the fractures and matrix upon exiting the waste emplacement drift. The fracture-matrix partitioning model computes the partitioning, between fractures and matrix, of diffusive radionuclide transport from the invert (for drifts without seepage) into the rock water. The invert is the structure constructed in a drift to provide the floor of the

  2. Water content estimated from point scale to plot scale

    Science.gov (United States)

    Akyurek, Z.; Binley, A. M.; Demir, G.; Abgarmi, B.

    2017-12-01

    Soil moisture controls the portioning of rainfall into infiltration and runoff. Here we investigate measurements of soil moisture using a range of techniques spanning different spatial scales. In order to understand soil water content in a test basin, 512 km2 in area, in the south of Turkey, a Cosmic Ray CRS200B soil moisture probe was installed at elevation of 1459 m and an ML3 ThetaProbe (CS 616) soil moisture sensor was established at 5cm depth used to get continuous soil moisture. Neutron count measurements were corrected for the changes in atmospheric pressure, atmospheric water vapour and intensity of incoming neutron flux. The calibration of the volumetric soil moisture was performed, from the laboratory analysis, the bulk density varies between 1.719 (g/cm3) -1.390 (g/cm3), and the dominant soil texture is silty clay loam and silt loamThe water content reflectometer was calibrated for soil-specific conditions and soil moisture estimates were also corrected with respect to soil temperature. In order to characterize the subsurface, soil electrical resistivity tomography was used. Wenner and Schlumberger array geometries were used with electrode spacing varied from 1m- 5 m along 40 m and 200 m profiles. From the inversions of ERT data it is apparent that within 50 m distance from the CRS200B, the soil is moderately resistive to a depth of 2m and more conductive at greater depths. At greater distances from the CRS200B, the ERT results indicate more resistive soils. In addition to the ERT surveys, ground penetrating radar surveys using a common mid-point configuration was used with 200MHz antennas. The volumetric soil moisture obtained from GPR appears to overestimate those based on TDR observations. The values obtained from CS616 (at a point scale) and CRS200B (at a mesoscale) are compared with the values obtained at a plot scale. For the field study dates (20-22.06.2017) the volumetric moisture content obtained from CS616 were 25.14%, 25.22% and 25

  3. The SCALE-UP Project

    Science.gov (United States)

    Beichner, Robert

    2015-03-01

    The Student Centered Active Learning Environment with Upside-down Pedagogies (SCALE-UP) project was developed nearly 20 years ago as an economical way to provide collaborative, interactive instruction even for large enrollment classes. Nearly all research-based pedagogies have been designed with fairly high faculty-student ratios. The economics of introductory courses at large universities often precludes that situation, so SCALE-UP was created as a way to facilitate highly collaborative active learning with large numbers of students served by only a few faculty and assistants. It enables those students to learn and succeed not only in acquiring content, but also to practice important 21st century skills like problem solving, communication, and teamsmanship. The approach was initially targeted at undergraduate science and engineering students taking introductory physics courses in large enrollment sections. It has since expanded to multiple content areas, including chemistry, math, engineering, biology, business, nursing, and even the humanities. Class sizes range from 24 to over 600. Data collected from multiple sites around the world indicates highly successful implementation at more than 250 institutions. NSF support was critical for initial development and dissemination efforts. Generously supported by NSF (9752313, 9981107) and FIPSE (P116B971905, P116B000659).

  4. The Regret/Disappointment Scale

    Directory of Open Access Journals (Sweden)

    Francesco Marcatto

    2008-01-01

    Full Text Available The present article investigates the effectiveness of methods traditionally used to distinguish between the emotions of regret and disappointment and presents a new method --- the Regret and Disappointment Scale (RDS --- for assessing the two emotions in decision making research. The validity of the RDS was tested in three studies. Study 1 used two scenarios, one prototypical of regret and the other of disappointment, to test and compare traditional methods (``How much regret do you feel'' and ``How much disappointment do you feel'' with the RDS. Results showed that only the RDS clearly differentiated between the constructs of regret and disappointment. Study 2 confirmed the validity of the RDS in a real-life scenario, in which both feelings of regret and disappointment could be experienced. Study 2 also demonstrated that the RDS can discriminate between regret and disappointment with results similar to those obtained by using a context-specific scale. Study 3 showed the advantages of the RDS over the traditional methods in gambling situations commonly used in decision making research, and provided evidence for the convergent validity of the RDS.

  5. Dynamic scaling in natural swarms

    Science.gov (United States)

    Cavagna, Andrea; Conti, Daniele; Creato, Chiara; Del Castello, Lorenzo; Giardina, Irene; Grigera, Tomas S.; Melillo, Stefania; Parisi, Leonardo; Viale, Massimiliano

    2017-09-01

    Collective behaviour in biological systems presents theoretical challenges beyond the borders of classical statistical physics. The lack of concepts such as scaling and renormalization is particularly problematic, as it forces us to negotiate details whose relevance is often hard to assess. In an attempt to improve this situation, we present here experimental evidence of the emergence of dynamic scaling laws in natural swarms of midges. We find that spatio-temporal correlation functions in different swarms can be rescaled by using a single characteristic time, which grows with the correlation length with a dynamical critical exponent z ~ 1, a value not found in any other standard statistical model. To check whether out-of-equilibrium effects may be responsible for this anomalous exponent, we run simulations of the simplest model of self-propelled particles and find z ~ 2, suggesting that natural swarms belong to a novel dynamic universality class. This conclusion is strengthened by experimental evidence of the presence of non-dissipative modes in the relaxation, indicating that previously overlooked inertial effects are needed to describe swarm dynamics. The absence of a purely dissipative regime suggests that natural swarms undergo a near-critical censorship of hydrodynamics.

  6. Creating Large Scale Database Servers

    International Nuclear Information System (INIS)

    Becla, Jacek

    2001-01-01

    The BaBar experiment at the Stanford Linear Accelerator Center (SLAC) is designed to perform a high precision investigation of the decays of the B-meson produced from electron-positron interactions. The experiment, started in May 1999, will generate approximately 300TB/year of data for 10 years. All of the data will reside in Objectivity databases accessible via the Advanced Multi-threaded Server (AMS). To date, over 70TB of data have been placed in Objectivity/DB, making it one of the largest databases in the world. Providing access to such a large quantity of data through a database server is a daunting task. A full-scale testbed environment had to be developed to tune various software parameters and a fundamental change had to occur in the AMS architecture to allow it to scale past several hundred terabytes of data. Additionally, several protocol extensions had to be implemented to provide practical access to large quantities of data. This paper will describe the design of the database and the changes that we needed to make in the AMS for scalability reasons and how the lessons we learned would be applicable to virtually any kind of database server seeking to operate in the Petabyte region

  7. Creating Large Scale Database Servers

    Energy Technology Data Exchange (ETDEWEB)

    Becla, Jacek

    2001-12-14

    The BaBar experiment at the Stanford Linear Accelerator Center (SLAC) is designed to perform a high precision investigation of the decays of the B-meson produced from electron-positron interactions. The experiment, started in May 1999, will generate approximately 300TB/year of data for 10 years. All of the data will reside in Objectivity databases accessible via the Advanced Multi-threaded Server (AMS). To date, over 70TB of data have been placed in Objectivity/DB, making it one of the largest databases in the world. Providing access to such a large quantity of data through a database server is a daunting task. A full-scale testbed environment had to be developed to tune various software parameters and a fundamental change had to occur in the AMS architecture to allow it to scale past several hundred terabytes of data. Additionally, several protocol extensions had to be implemented to provide practical access to large quantities of data. This paper will describe the design of the database and the changes that we needed to make in the AMS for scalability reasons and how the lessons we learned would be applicable to virtually any kind of database server seeking to operate in the Petabyte region.

  8. Goethite Bench-scale and Large-scale Preparation Tests

    Energy Technology Data Exchange (ETDEWEB)

    Josephson, Gary B.; Westsik, Joseph H.

    2011-10-23

    The Hanford Waste Treatment and Immobilization Plant (WTP) is the keystone for cleanup of high-level radioactive waste from our nation's nuclear defense program. The WTP will process high-level waste from the Hanford tanks and produce immobilized high-level waste glass for disposal at a national repository, low activity waste (LAW) glass, and liquid effluent from the vitrification off-gas scrubbers. The liquid effluent will be stabilized into a secondary waste form (e.g. grout-like material) and disposed on the Hanford site in the Integrated Disposal Facility (IDF) along with the low-activity waste glass. The major long-term environmental impact at Hanford results from technetium that volatilizes from the WTP melters and finally resides in the secondary waste. Laboratory studies have indicated that pertechnetate ({sup 99}TcO{sub 4}{sup -}) can be reduced and captured into a solid solution of {alpha}-FeOOH, goethite (Um 2010). Goethite is a stable mineral and can significantly retard the release of technetium to the environment from the IDF. The laboratory studies were conducted using reaction times of many days, which is typical of environmental subsurface reactions that were the genesis of this new process. This study was the first step in considering adaptation of the slow laboratory steps to a larger-scale and faster process that could be conducted either within the WTP or within the effluent treatment facility (ETF). Two levels of scale-up tests were conducted (25x and 400x). The largest scale-up produced slurries of Fe-rich precipitates that contained rhenium as a nonradioactive surrogate for {sup 99}Tc. The slurries were used in melter tests at Vitreous State Laboratory (VSL) to determine whether captured rhenium was less volatile in the vitrification process than rhenium in an unmodified feed. A critical step in the technetium immobilization process is to chemically reduce Tc(VII) in the pertechnetate (TcO{sub 4}{sup -}) to Tc(Iv)by reaction with the

  9. SCALE INTERACTION IN A MIXING LAYER. THE ROLE OF THE LARGE-SCALE GRADIENTS

    KAUST Repository

    Fiscaletti, Daniele

    2015-08-23

    The interaction between scales is investigated in a turbulent mixing layer. The large-scale amplitude modulation of the small scales already observed in other works depends on the crosswise location. Large-scale positive fluctuations correlate with a stronger activity of the small scales on the low speed-side of the mixing layer, and a reduced activity on the high speed-side. However, from physical considerations we would expect the scales to interact in a qualitatively similar way within the flow and across different turbulent flows. Therefore, instead of the large-scale fluctuations, the large-scale gradients modulation of the small scales has been additionally investigated.

  10. Combined Adjuvant Radiochemotherapy With IMRT/XELOX Improves Outcome With Low Renal Toxicity in Gastric Cancer

    International Nuclear Information System (INIS)

    Boda-Heggemann, Judit; Hofheinz, Ralf-Dieter; Weiss, Christel; Mennemeyer, Philipp; Mai, Sabine K.; Hermes, Petra; Wertz, Hansjoerg; Post, Stefan; Massner, Bernd; Hieber, Udo; Hochhaus, Andreas; Wenz, Frederik; Lohr, Frank

    2009-01-01

    Objectives: Adjuvant radiochemotherapy improves survival of patients with advanced gastric cancer. We assessed in two sequential cohorts whether improved radiotherapy technique (IMRT) together with intensified chemotherapy improves outcome vs. conventional three-dimensional conformal radiotherapy (3D-CRT) and standard chemotherapy in these patients while maintaining or reducing renal toxicity. Materials and Methods: Sixty consecutive patients treated for gastric cancer either with 3D-CRT (n = 27) and IMRT (n = 33) were evaluated. More than 70% had undergone D2 resection. Although there was a slight imbalance in R0 status between cohorts, N+ status was balanced. Chemotherapy consisted predominantly of 5-fluorouracil/folinic acid (n = 36) in the earlier cohort and mostly of oxaliplatin/capecitabine (XELOX, n = 24) in the later cohort. Primary end points were overall survival (OS), disease-free survival (DFS), and renal toxicity based on creatinine levels. Results: Median follow-up (FU) of all patients in the 3D-CRT group was 18 months and in the IMRT group 22 months (median FU of surviving patients 67 months in the 3D-CRT group and 25 months in the IMRT group). Overall median survival (and DFS) were 18 (13) months in the 3D-CRT group and both not reached in the IMRT group (p = 0.0492 and 0.0216). Actuarial 2-year survival was 37% and 67% in the 3D-CRT and IMRT groups, respectively. No late renal toxicity >Grade 2 (LENT-SOMA scale) was observed in either cohort. Conclusion: When comparing sequentially treated patient cohorts with similar characteristics, OS and DFS improved with the use of IMRT and intensified chemotherapy without signs of increased renal toxicity.

  11. Late Side Effects and Quality of Life After Radiotherapy for Rectal Cancer

    International Nuclear Information System (INIS)

    Bruheim, Kjersti; Guren, Marianne G.; Skovlund, Eva; Hjermstad, Marianne J.; Dahl, Olav; Frykholm, Gunilla; Carlsen, Erik; Tveit, Kjell Magne

    2010-01-01

    Purpose: There is little knowledge on long-term morbidity after radiotherapy (50 Gy) and total mesorectal excision for rectal cancer. Therefore, late effects on bowel, anorectal, and urinary function, and health-related quality of life (QoL), were studied in a national cohort (n = 535). Methods and Materials: All Norwegian patients who received pre- or postoperative (chemo-)radiotherapy for rectal cancer from 1993 to 2003 were identified. Patients treated with surgery alone served as controls. Patients were without recurrence or metastases. Bowel and urinary function was scored with the LENT SOMA scale and the St. Marks Score for fecal incontinence and QoL with the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30). Results: Median time since surgery was 4.8 years. Radiation-treated (RT+) patients (n = 199) had increased bowel frequency compared with non-radiation-treated (RT-) patients (n = 336); 19% vs. 6% had more than eight daily bowel movements (p < 0.001). In patients without stoma, a higher proportion of RT+ (n = 69) compared with RT- patients (n = 240), were incontinent for liquid stools (49% vs. 15%, p < 0.001), needed a sanitary pad (52% vs. 13%, p < 0.001), and lacked the ability to defer defecation (44% vs. 16%, p < 0.001). Daily urinary incontinence occurred more frequently after radiotherapy (9% vs. 2%, p = 0.001). Radiation-treated patients had worse social function than RT- patients, and patients with fecal or urinary incontinence had impaired scores for global quality of life and social function (p < 0.001). Conclusions: Radiotherapy for rectal cancer is associated with considerable long-term effects on anorectal function, especially in terms of bowel frequency and fecal incontinence. RT+ patients have worse social function, and fecal incontinence has a negative impact on QoL.

  12. Preservation of parotid function with uncomplicated conformal radiotherapy

    International Nuclear Information System (INIS)

    Maes, Annelies; Weltens, Caroline; Flamen, Patrick; Lambin, Philippe; Bogaerts, Ria; Liu, Xuan; Baetens, Jan; Hermans, Robert; Van den Bogaert, Walter

    2002-01-01

    Background and purpose: To evaluate (1) parotid function, (2) subjective xerostomia and (3) pattern of relapses after conformal parotid-sparing radiotherapy (RT) for head and neck cancer. (4) To study dose-response curves of parotid glands. Material and methods: From September 1999 to November 2000, 39 head and neck cancer patients requiring bilateral neck RT were treated with a fairly simple conformal RT technique (three-field set-up+anterior lower neck field; two opposed oblique boost fields). The contralateral parotid was spared. Parotid function was assessed by salivary gland scintigraphies performed before, early (median 4 weeks) and late (median 28 weeks) after RT. Xerostomia was monitored by visual analogue scales (VAS) and LENT SOMA scores. Location of locoregional recurrences was studied in relation to the radiation fields. A dose-response curve of parotids was created using logistic regression. Results: (1) Early after RT, on salivary gland scintigraphy, the mean loss of secretion function in the spared parotid was 67% and total in the non-spared. Late after RT, the mean loss remained 19% in the spared and total in the non-spared parotid. Normal excretion function was regained in 75% of the spared parotids. (2) Late after RT, 78% of patients had no, minimal or acceptable subjective xerostomia. (3) No recurrence was seen near the spared parotid (11/39 locoregional recurrences). (4) The dose-response curve of parotids showed that the mean parotid dose should preferentially be ≤20 Gy, to obtain a good chance (≥70%) for preservation of its function on scintigraphy. Conclusions: An easy conformal parotid-sparing RT technique prevents moderate or severe subjective xerostomia in 78% of patients. In the spared parotids, nearly complete to complete recovery is obtained after 6-12 months

  13. Effect of a prostaglandin - given rectally for prevention of radiation-induced acute proctitis - on late rectal toxicity. Results of phase III randomized, placebo-controlled, double-blind study

    International Nuclear Information System (INIS)

    Kertesz, Tereza; Herrmann, Markus K.A.; Christiansen, Hans; Hermann, Robert M.; Hess, Clemens F.; Hille, Andrea; Zapf, Antonia; Pradier, Olivier; Schmidberger, Heinz

    2009-01-01

    Background and purpose: to assess the late effect of a prostaglandin, given rectally during irradiation, on late rectal toxicity. In the acute treatment setting no significant differences in reducing the incidence of acute proctitis symptoms in patients receiving misoprostol, however, significantly more rectal bleeding had been reported. Patients and methods: a total of 100 patients who had undergone radiotherapy for prostate cancer had been entered into this phase III randomized, placebo-controlled, double-blind study with misoprostol or placebo suppositories. The toxicity was evaluated yearly after cessation of irradiation by the RTOG/LENT-SOMA scale. Results: the median follow-up was 50 months. 20 patients suffered from grade 1, four patients from grade 2 as well, and three patients only from grade 2 toxicity. Frequency, bleeding and urgency were the most commonly reported symptoms. In keeping with other studies and clinical experience, the symptoms peaked within the first 2 years with a median for grade 1 of 13 months and for grade 2 of 15 months. The presence of acute toxicity grade 2 showed a correlation with the development of any late toxicity (p = 0.03). Any acute rectal bleeding was significant correlated with any late rectal bleeding (p = 0.017). Conclusion: misoprostol given as once-daily suppository for prevention of acute radiation-induced proctitis does neither influence the incidence and severity of radiation-induced acute nor late rectal toxicity. Misoprostol has no negative impact on the incidence and severity of late rectal bleeding, in contrast to acute rectal bleeding. The routine clinical use of misoprostol suppositories cannot be recommended. (orig.)

  14. Effect of a prostaglandin - given rectally for prevention of radiation-induced acute proctitis - on late rectal toxicity. Results of phase III randomized, placebo-controlled, double-blind study

    Energy Technology Data Exchange (ETDEWEB)

    Kertesz, Tereza; Herrmann, Markus K.A.; Christiansen, Hans; Hermann, Robert M.; Hess, Clemens F.; Hille, Andrea [Dept. of Radiotherapy and Radiooncology, Univ. of Goettingen (Germany); Zapf, Antonia [Dept. of Medical Statistics, Univ. of Goettingen (Germany); Pradier, Olivier [Dept. of Radiotherapy and Radiooncology, Univ. of Brest (France); Schmidberger, Heinz [Dept. of Radiotherapy and Radiooncology, Univ. of Mainz (Germany)

    2009-09-15

    Background and purpose: to assess the late effect of a prostaglandin, given rectally during irradiation, on late rectal toxicity. In the acute treatment setting no significant differences in reducing the incidence of acute proctitis symptoms in patients receiving misoprostol, however, significantly more rectal bleeding had been reported. Patients and methods: a total of 100 patients who had undergone radiotherapy for prostate cancer had been entered into this phase III randomized, placebo-controlled, double-blind study with misoprostol or placebo suppositories. The toxicity was evaluated yearly after cessation of irradiation by the RTOG/LENT-SOMA scale. Results: the median follow-up was 50 months. 20 patients suffered from grade 1, four patients from grade 2 as well, and three patients only from grade 2 toxicity. Frequency, bleeding and urgency were the most commonly reported symptoms. In keeping with other studies and clinical experience, the symptoms peaked within the first 2 years with a median for grade 1 of 13 months and for grade 2 of 15 months. The presence of acute toxicity grade 2 showed a correlation with the development of any late toxicity (p = 0.03). Any acute rectal bleeding was significant correlated with any late rectal bleeding (p = 0.017). Conclusion: misoprostol given as once-daily suppository for prevention of acute radiation-induced proctitis does neither influence the incidence and severity of radiation-induced acute nor late rectal toxicity. Misoprostol has no negative impact on the incidence and severity of late rectal bleeding, in contrast to acute rectal bleeding. The routine clinical use of misoprostol suppositories cannot be recommended. (orig.)

  15. Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: Long-term results of the ARCOSEIN multicenter randomized study

    International Nuclear Information System (INIS)

    Toledano, Alain; Garaud, Pascal; Serin, Daniel; Fourquet, Alain; Bosset, Jean-Francois; Breteau, Noel; Body, Gilles; Azria, David; Le Floch, Olivier; Calais, Gilles

    2006-01-01

    Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. Methods and Materials: A total of 297 patients from the 5 larger participating institutions were asked to report for a follow-up examination. Seventy-two percent (214 patients) were eligible for evaluation of late toxicity. After breast-conserving surgery, patients were treated either with sequential treatment with CT first followed by RT (Arm A) or CT administered concurrently with RT (Arm B). In all patients, CT regimen consisted of mitoxantrone (12 mg/m 2 ), 5-FU (500 mg/m 2 ), and cyclophosphamide (500 mg/m 2 ), 6 cycles (Day 1 to Day 21). Conventional RT was delivered to the whole breast by administration of a 2 Gy per fraction protocol to a total dose of 50 Gy (± boost to the primary tumor bed). The assessment of toxicity was blinded to treatment and was graded by the radiation oncologist, according to the LENT/SOMA scale. Skin pigmentation was also evaluated according to a personal 5-points scoring system (excellent, good, moderate, poor, very poor). Results: Among the 214 evaluable patients, 107 were treated in each arm. The 2 populations were homogeneous for patient, tumor, and treatment characteristics. Subcutaneous fibrosis (SF), telangectasia (T), skin pigmentation (SP), and breast atrophy (BA) were significantly increased in Arm B. No statistical difference was observed between the 2 arms of the study concerning Grade 2 or higher pain, breast edema, or lymphedema. No deaths were caused by late toxicity. Conclusion: After breast-conserving surgery, the concurrent use of CT with RT is significantly associated with an increase incidence of Grade 2 or greater late side effects

  16. Breast conserving surgery in combination with intraoperative radiotherapy after previous external beam therapy: an option to avoid mastectomy.

    Science.gov (United States)

    Thangarajah, F; Heilmann, J; Malter, W; Kunze, S; Marnitz, S; Mallmann, P; Wenz, F; Sperk, E

    2018-04-01

    Mastectomy is the standard procedure in patients with in-breast tumor recurrence (IBTR) or breast cancer after irradiation of the chest due to Hodgkin's disease. In certain cases a second breast conserving surgery (BCS) in combination with intraoperative radiotherapy (IORT) is possible. To date, data concerning BCS in combination with IORT in pre-irradiated patients are limited. This is the first pooled analysis of this special indication with a mature follow-up of 5 years. Patients with IBTR after external beam radiotherapy (EBRT; treated in two centers) for breast cancer were included. Patients with previous EBRT including the breast tissue due to other diseases were also included. IORT was performed with the Intrabeam™-device using low kV X-rays. Clinical data including outcome for all patients and toxicity for a representative cohort (LENT-SOMA scales) were obtained. Statistical analyses were done including Kaplan-Meier estimates for local recurrence, distant metastasis and overall survival. A total of 41 patients were identified (39 patients with IBTR, 2 with Hodgkin`s disease in previous medical history). Median follow-up was 58 months (range 4-170). No grade 3/4 acute toxicity occurred within 9 weeks. Local recurrence-free survival rate was 89.9% and overall survival was 82.7% at 5 years. Seven patients developed metastasis within the whole follow-up. BCS in combination with IORT in IBTR in pre-irradiated patients is a feasible method to avoid mastectomy with a low risk of side effects and an excellent local control and good overall survival.

  17. Time course of late rectal- and urinary bladder side effects after MRI-guided adaptive brachytherapy for cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Georg, P.; Georg, D.; Poetter, R.; Doerr, W. [Medical University Vienna/ AKH Wien (Austria). Dept. of Radiooncology; Medical University Vienna (Austria). Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology; Medical University Vienna/ AKH Wien (Austria). Comprehensive Cancer Centre; Boni, A.; Ghabuous, A. [Medical University Vienna/ AKH Wien (Austria). Dept. of Radiooncology; Goldner, G.; Schmid, M.P. [Medical University Vienna/ AKH Wien (Austria). Dept. of Radiooncology; Medical University Vienna/ AKH Wien (Austria). Comprehensive Cancer Centre

    2013-07-15

    Background and purpose: To analyze the time course of late rectal- and urinary bladder complications after brachytherapy for cervical cancer and to compare the incidence- and prevalence rates thereof. Patients and methods: A total of 225 patients were treated with external-beam radiotherapy (EBRT) and magnetic resonance imaging (MRI)-guided brachytherapy with or without chemotherapy. Late side effects were assessed prospectively using the Late Effects in Normal Tissue - Subjective, Objective, Management and Analytic (LENT/SOMA) scale. The parameters analyzed were time to onset, duration, actuarial incidence- (occurrence of new side effects during a defined time period) and prevalence rates (side effects existing at a defined time point). Results: Median follow-up was 44 months. Side effects (grade 1-4) in rectum and bladder were present in 31 and 49 patients, 14 and 27 months (mean time to onset) after treatment, respectively. All rectal and 76 % of bladder side effects occurred within 3 years after radiotherapy. Mean duration of rectal events was 19 months; 81 % resolved within 3 years of their initial diagnosis. Mean duration of bladder side effects was 20 months; 61 % resolved within 3 years. The 3- and 5-year actuarial complication rates were 16 and 19 % in rectum and 18 and 28 % in bladder, respectively. The corresponding prevalence rates were 9 and 2 % (rectum) and 18 and 21 % (bladder), respectively. Conclusion: Late side effects after cervical cancer radiotherapy are partially reversible, but their time course is organ-dependent. The combined presentation of incidence- and prevalence rates provides the most comprehensive information. (orig.)

  18. Time course of late rectal- and urinary bladder side effects after MRI-guided adaptive brachytherapy for cervical cancer

    International Nuclear Information System (INIS)

    Georg, P.; Georg, D.; Poetter, R.; Doerr, W.; Medical University Vienna; Medical University Vienna/ AKH Wien; Boni, A.; Ghabuous, A.; Goldner, G.; Schmid, M.P.; Medical University Vienna/ AKH Wien

    2013-01-01

    Background and purpose: To analyze the time course of late rectal- and urinary bladder complications after brachytherapy for cervical cancer and to compare the incidence- and prevalence rates thereof. Patients and methods: A total of 225 patients were treated with external-beam radiotherapy (EBRT) and magnetic resonance imaging (MRI)-guided brachytherapy with or without chemotherapy. Late side effects were assessed prospectively using the Late Effects in Normal Tissue - Subjective, Objective, Management and Analytic (LENT/SOMA) scale. The parameters analyzed were time to onset, duration, actuarial incidence- (occurrence of new side effects during a defined time period) and prevalence rates (side effects existing at a defined time point). Results: Median follow-up was 44 months. Side effects (grade 1-4) in rectum and bladder were present in 31 and 49 patients, 14 and 27 months (mean time to onset) after treatment, respectively. All rectal and 76 % of bladder side effects occurred within 3 years after radiotherapy. Mean duration of rectal events was 19 months; 81 % resolved within 3 years of their initial diagnosis. Mean duration of bladder side effects was 20 months; 61 % resolved within 3 years. The 3- and 5-year actuarial complication rates were 16 and 19 % in rectum and 18 and 28 % in bladder, respectively. The corresponding prevalence rates were 9 and 2 % (rectum) and 18 and 21 % (bladder), respectively. Conclusion: Late side effects after cervical cancer radiotherapy are partially reversible, but their time course is organ-dependent. The combined presentation of incidence- and prevalence rates provides the most comprehensive information. (orig.)

  19. Dimensional analysis, scaling and fractals

    International Nuclear Information System (INIS)

    Timm, L.C.; Reichardt, K.; Oliveira Santos Bacchi, O.

    2004-01-01

    Dimensional analysis refers to the study of the dimensions that characterize physical entities, like mass, force and energy. Classical mechanics is based on three fundamental entities, with dimensions MLT, the mass M, the length L and the time T. The combination of these entities gives rise to derived entities, like volume, speed and force, of dimensions L 3 , LT -1 , MLT -2 , respectively. In other areas of physics, four other fundamental entities are defined, among them the temperature θ and the electrical current I. The parameters that characterize physical phenomena are related among themselves by laws, in general of quantitative nature, in which they appear as measures of the considered physical entities. The measure of an entity is the result of its comparison with another one, of the same type, called unit. Maps are also drawn in scale, for example, in a scale of 1:10,000, 1 cm 2 of paper can represent 10,000 m 2 in the field. Entities that differ in scale cannot be compared in a simple way. Fractal geometry, in contrast to the Euclidean geometry, admits fractional dimensions. The term fractal is defined in Mandelbrot (1982) as coming from the Latin fractus, derived from frangere which signifies to break, to form irregular fragments. The term fractal is opposite to the term algebra (from the Arabic: jabara) which means to join, to put together the parts. For Mandelbrot, fractals are non topologic objects, that is, objects which have as their dimension a real, non integer number, which exceeds the topologic dimension. For the topologic objects, or Euclidean forms, the dimension is an integer (0 for the point, 1 for a line, 2 for a surface, and 3 for a volume). The fractal dimension of Mandelbrot is a measure of the degree of irregularity of the object under consideration. It is related to the speed by which the estimate of the measure of an object increases as the measurement scale decreases. An object normally taken as uni-dimensional, like a piece of a

  20. Scaling criteria for rock dynamic experiments

    Energy Technology Data Exchange (ETDEWEB)

    Crowley, Barbara K [Lawrence Radiation Laboratory, University of California, Livermore, CA (United States)

    1970-05-01

    A set of necessary conditions for performing scaled rock dynamics experiments is derived from the conservation equations of continuum mechanics. Performing scaled experiments in two different materials is virtually impossible because of the scaling restrictions imposed by two equations of state. However, performing dynamically scaled experiments in the same material is possible if time and distance use the same scaling factor and if the effects of gravity are insignificant. When gravity becomes significant, dynamic scaling is no longer possible. To illustrate these results, example calculations of megaton and kiloton experiments are considered. (author00.