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Sample records for lens barrel structure

  1. Alignment of the MSGC barrel support structure

    International Nuclear Information System (INIS)

    Kari, Tammi; Miikka, Kotamaki; Tommi, Vanhala; Antti, Onnela

    1999-01-01

    The MSGC barrel is a sub-part of the tracking system of the CMS experiment at the LHC. The mechanical support structure of the MSGC barrel consists of ladder-like support beams carrying the detector modules and of four disks supporting the ladders. The required alignment precision of the modules, a few tens of micrometers, is designed to be obtained by precise part manufacture and by careful measurement of the alignment during the assembly of the structure. In the paper the use of digital photogrammetry for the measurement of the alignment of the disks and for the structural verification is presented. Digital photogrammetry was chosen from a number of potential methods after a careful evaluation. The use of photogrammetry for the structural verification of a prototype is presented. The displacements were measured both of unloaded and loaded disk by using photogrammetry and linear displacement transducers for verification. The displacements obtained from the two measurement methods corresponded well, not only to each other, but also to the results given by finite element analysis. The structural verification will be done and the alignment procedure will be tested with a full-sized prototype of a half of the MSGC barrel. Preparations for the photogrammetry measurements are presented and the design of the required supplementary equipment is shown. (authors)

  2. Mechanical structure of the TOPAZ barrel drift chamber

    International Nuclear Information System (INIS)

    Morimoto, T.; Maruyama, K.; Okuno, H.

    1987-07-01

    A Barrel Drift Chamber (BDC) is constructed for the TOPAZ experiment at TRISTAN, KEK. The BDC has a cylindrical shape with dimensions of 325.2 cm in inner diameter, 347.2 cm in outer diameter and 500 cm long. It consists of 1232 drift tubes made of conductive plastic cathodes, which are staggered in four layers. In this report, a design of the mechanical structure and construction procedures are described in detail. (author)

  3. Fluid and structural dynamics calculations to determine core barrel loads during blowdown (EV 3,000)

    International Nuclear Information System (INIS)

    Krieg, R.; Schlechtendahl, E.G.

    1977-01-01

    To begin with, the main physical phenomena in connection with blowdown loads on the care barrel and the computer models used are briefly described. These models have also been used in the design of the HTR test care barrel. The fluid dynamics part of the calculations was carried out using the WHAMMOD and DAPSY codes; for the structural dynamics part, the STRUDL/Dynal code was employed. (orig./RW) [de

  4. The control on the deformation of the ATLAS barrel toroid warm structure

    CERN Document Server

    Bauer, F; Giraud, P F; Védrine, P; Guyot, C; Levesy, B; Ponsot, P; Schune, P; Sun, Z

    2007-01-01

    The ATLAS barrel toroid warm structure supports the barrel toroid and the muon detectors. The warm structure is about 26 meters long with an outer diameter of 20 meters. In order to ensure the physics performance of the muon detectors, the deformation of the warm structure is minimised during the design phase. The barrel toroid assembly has been carried out in the cavern of the ATLAS experiment since end of 2004. In September 2005, the warm structure has been completely released. The release has been followed-up in real time using optical alignment sensors. Good agreement has been found within 1 mm, between the alignment system measurement, the geometer survey and the predicted values according to the finite element analyses results.

  5. Fluid-structure coupled dynamic response of PWR core barrel during LOCA

    International Nuclear Information System (INIS)

    Lu, M.W.; Zhang, Y.G.; Shi, F.

    1991-01-01

    This paper is engaged in the Fluid-Structure Interaction LOCA analysis of the core barrel of PWR. The analysis is performed by a multipurpose computer code SANES. The FSI inside the pressure vessel is treated by a FEM code including some structural and acoustic elements. The transient in the primary loop is solved by a two-phase flow code. Both codes are coupled one another. Some interesting conclusions are drawn. (author)

  6. Barrels XXIX: Barrels go Hollywood.

    Science.gov (United States)

    Evans, Mathew H; Brumberg, Joshua C

    2017-03-01

    Barrels XXIX brought together researchers focusing on the rodent barrel cortex and associated systems. The meeting revolved around three themes: thalamocortical interactions in motor control, touch in rodent, monkey, and humans, and the nature of the multisensory computations the brain makes. Over two days these topics were covered as well as many more presentations that focused on the physiology, behavior, and development of the rodent whisker-to-barrel cortex system.

  7. SmI cortical barrels in an Australian marsupial, Trichosurus vulpecula (brush-tailed possum): structural organization, patterned distribution, and somatotopic relationships.

    Science.gov (United States)

    Weller, W L

    1993-11-15

    This study reports on the cerebral cortex of an Australian marsupial, Trichosurus vulpecula (brush-tailed possum). It consists of an analysis of layer IV of somatosensory cortex in tangential sections of flattened specimens and in oblique radial sections stained to show Nissl substance or myelin, or tested for succinic dehydrogenase. It includes results of electrophysiological mapping experiments that ascertained the somatotopic significance of the cytoarchitecture of this cortical region. Layer IV has two interlocking cytoarchitectural fields: one granular (the barrelfield, comprising cell-dense barrels 150 to 500 microns in diameter) and one dysgranular. Only neurons within the granular field responded to light cutaneous stimulation. In the barrelfield cell-sparse septa (about 100 microns wide), low in succinic dehydrogenase activity and containing many radial myelinated axons, separate adjoining barrels. Possum barrels are "solid," lacking the prominent hollows characteristic of most rodent barrels. In some specimens three to five small neuronal "lobules" may constitute each large barrel. In tangential sections the size, shape, and arrangement of barrels combine to form a histological caricature of the possum's body, especially of the face and forepaw. Six rows of "mystacial barrels" are homeomorphic to the six rows of large mystacial vibrissae, and "forepaw barrels" are homeomorphic to the glabrous palmar and apical digital pads. Correlating cortical recording sites and receptive fields confirmed that individual barrels represent specific cutaneous regions. These results show that the cortical barrels of brush-tailed possums are remarkably similar to those of rodents, in structure, arrangement, and functional significance.

  8. Barrelled locally convex spaces

    CERN Document Server

    Pérez Carreras, P

    1987-01-01

    This book is a systematic treatment of barrelled spaces, and of structures in which barrelledness conditions are significant. It is a fairly self-contained study of the structural theory of those spaces, concentrating on the basic phenomena in the theory, and presenting a variety of functional-analytic techniques.Beginning with some basic and important results in different branches of Analysis, the volume deals with Baire spaces, presents a variety of techniques, and gives the necessary definitions, exploring conditions on discs to ensure that they are absorbed by the barrels of the sp

  9. The PANDA Barrel DIRC

    Science.gov (United States)

    Schwiening, J.; Ali, A.; Belias, A.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Traxler, M.; Böhm, M.; Eyrich, W.; Lehmann, A.; Pfaffinger, M.; Uhlig, F.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kreutzfeld, K.; Merle, O.; Rieke, J.; Schmidt, M.; Wasem, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

    2018-03-01

    The PANDA experiment at the international accelerator Facility for Antiproton and Ion Research in Europe (FAIR) near GSI, Darmstadt, Germany will address fundamental questions of hadron physics. Excellent Particle Identification (PID) over a large range of solid angles and particle momenta will be essential to meet the objectives of the rich physics program. Charged PID for the barrel region of the PANDA target spectrometer will be provided by a DIRC (Detection of Internally Reflected Cherenkov light) detector. The Barrel DIRC will cover the polar angle range of 22o-140o and cleanly separate charged pions from kaons for momenta between 0.5 GeV/c and 3.5 GeV/c with a separation power of at least 3 standard deviations. The design is based on the successful BABAR DIRC and the SuperB FDIRC R&D with several important improvements to optimize the performance for PANDA, such as a focusing lens system, fast timing, a compact fused silica prism as expansion region, and lifetime-enhanced Microchannel-Plate PMTs for photon detection. This article describes the technical design of the PANDA Barrel DIRC and the result of the design validation using a "vertical slice" prototype in hadronic particle beams at the CERN PS.

  10. The Metric Lens : Visualizing Metrics and Structure on Software Diagrams

    NARCIS (Netherlands)

    Byelas, Heorhiy; Telea, Alexandru; Hassan, AE; Zaidman, A; DiPenta, M

    2008-01-01

    We present the metric lens, a new visualization of method-level code metrics atop UML class diagrams, which allows performing metric-metric and metric-structure correlations on large diagrams. Me demonstrate air interactive visualization tool in which users can quickly specify a wide palette of

  11. TRT Barrel milestones passed

    CERN Multimedia

    Ogren, H

    2004-01-01

    The barrel TRT detector passed three significant milestones this spring. The Barrel Support Structure (BSS) was completed and moved to the SR-1 building on February 24th. On March 12th the first module passed the quality assurance testing in Building 154 and was transported to the assembly site in the SR-1 building for barrel assembly. Then on April 21st the final production module that had been scanned at Hampton University was shipped to CERN. TRT Barrel Module Production The production of the full complement of barrel modules (96 plus 9 total spares) is now complete. This has been a five-year effort by Duke University, Hampton University, and Indiana University. Actual construction of the modules in the United States was completed in the first part of 2004. The production crews at each of the sites in the United States have now completed their missions. They are shown in the following pictures. Duke University: Production crew with the final completed module. Indiana University: Module producti...

  12. Novel fabrication technique of hybrid structure lens array for 3D images

    Science.gov (United States)

    Lee, Junsik; Kim, Junoh; Kim, Cheoljoong; Shin, Dooseub; Koo, Gyohyun; Won, Yong Hyub

    2016-03-01

    Tunable liquid lens arrays can produce three dimensional images by using electrowetting principle that alters surface tensions by applying voltage. This method has advantages of fast response time and low power consumption. However, it is challenging to fabricate a high fill factor liquid lens array and operate three dimensional images which demand high diopter. This study describes a hybrid structure lens array which has not only a liquid lens array but a solid lens array. A concave-shape lens array is unavoidable when using only the liquid lens array and some voltages are needed to make the lens flat. By placing the solid lens array on the liquid lens array, initial diopter can be positive. To fabricate the hybrid structure lens array, a conventional lithographic process in semiconductor manufacturing is needed. A negative photoresist SU-8 was used as chamber master molds. PDMS and UV adhesive replica molding are done sequentially. Two immiscible liquids, DI water and dodecane, are injected in the fabricated chamber, followed by sealing. The fabricated structure has a 20 by 20 pattern of cylindrical shaped circle array and the aperture size of each lens is 1mm. The thickness of the overall hybrid structure is about 2.8mm. Hybrid structure lens array has many advantages. Solid lens array has almost 100% fill factor and allow high efficiency. Diopter can be increased by more than 200 and negative diopter can be shifted to the positive region. This experiment showed several properties of the hybrid structure and demonstrated its superiority.

  13. Weapons barrel life cycle determination

    Directory of Open Access Journals (Sweden)

    Nebojša Pene Hristov

    2013-10-01

    Full Text Available This article describes the dynamic processes within the gun barrel during the firing process in exploitation. It generally defines the basic principles of constructing tube elements, and shows the distortion of the basic geometry of the tube interior due to wear as well as the impact it causes during exploitation. The article also defines basic empirical models as well as a model based on fracture mechanics for the calculation of a use-life of the barrel, and other elements essential for the safe use of the barrel as the basic weapon element. Erosion causes are analysed in order to control and reduce wear and prolong the lifetime of the gun barrel. It gives directions for the reparation of barrels with wasted resources. In conclusion, the most influential elements of tube wear are given as well as possible modifications of existing systems, primarily propellant charges, with a purpose of prolonging lifetime of gun barrels. The guidelines for a proper determination of the lifetime based on the barrel condition assessment are given as well. INTRODUCTION The barrel as the basic element of each weapon is described as well as the processes occurring during the firing that have impulsive character and are accompanied by large amounts of energy. The basic elements of barrel and itheir constructive characteristics are descibed. The relation between Internal ballistics, ie calculation of the propellant gas pressure in the firing process, and structural elements defined by the barrel material resistance is shown. In general, this part of the study explains the methodology of the gun barrel structural elements calculation, ie. barrel geometry, taking into account the degrees of safety in accordance with Military Standards.   TUBE WEAR AND DEFORMATIONS The weapon barrel gradually wears out during exploitation due to which it no longer satisfies the set requirements. It is considered that the barrel has experienced a lifetime when it fails to fulfill the

  14. Work on a ATLAS tile calorimeter Barrel

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    The Tile Calorimeter is designed as one barrel and two extended barrel hadron parts. The calorimeter consists of a cylindrical structure with inner and outer radius of 2280 and 4230 mm respectively. The barrel part is 5640 mm in length along the beam axis, while each of the extended barrel cylinders is 2910 mm long. Each detector cylinder is built of 64 independent wedges along the azimuthal direction. Between the barrel and the extended barrels there is a gap of about 600 mm, which is needed for the Inner Detector and the Liquid Argon cables, electronics and services. The barrel covers the region -1.0barrels cover the region 0.8<|h|<1.7.

  15. Refractive lens exchange and piggyback intraocular lens implantation in nanophthalmos: Visual and structural outcomes.

    Science.gov (United States)

    Mohebbi, Masoomeh; Fallah-Tafti, Mohammad-Reza; Fadakar, Kaveh; Katoozpour, Ramon; Mohammadi, Seyed-Farzad; Fallah-Tafti, Zahra; Khorami, Azita

    2017-09-01

    To evaluate the best piggyback intraocular lens (IOL) implantation method and the outcomes in nanophthalmos eyes and to define the postoperative structural changes. Farabi Eye Hospital, Tehran, Iran. Prospective case series. Candidates for refractive surgery who were nanophthalmic were recruited. Patients had refractive lens exchange followed by implantation of both IOLs in the bag or 1 IOL in the bag and 1 IOL in the sulcus. The baseline and follow-up visual acuity, refractive status, and structural Scheimpflug imaging were evaluated. Ultrasound biomicroscopy (UBM) was performed 6 months postoperatively. The study comprised 9 nanophthalmic patients (18 eyes) with a mean preoperative uncorrected distance visual acuity (UDVA) of 1.53 logarithm of the minimum angle of resolution (logMAR) ± 0.3 (SD), mean corrected distance visual acuity (CDVA) of 0.34 ± 0.2 logMAR, and mean spherical equivalent (SE) of +13.55 ± 4.0 diopters (D). The mean postoperative UDVA improved from baseline. There was no significant difference in the mean UDVA and CDVA between the 2 IOL groups. Postoperatively, both groups had a significant improvement in SE, a significant rise in anterior chamber depth and angle, and similar UBM measurements. Piggyback IOL implantation was an effective refractive procedure in nanophthalmic eyes. Both implantation methods resulted in similar outcomes; however, the small number of patients in each group made it less likely that possible differences would be found. The increase in angle values might help prevent the development of closed-angle glaucoma. Copyright © 2017 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  16. Functional testing of the ATLAS SCT barrels

    International Nuclear Information System (INIS)

    Phillips, Peter W.

    2007-01-01

    The ATLAS SCT (semiconductor tracker) comprises 2112 barrel modules mounted on four concentric barrels of length 1.6m and up to 1m diameter, and 1976 endcap modules supported by a series of nine wheels at each end of the barrel region, giving a total silicon area of 60m 2 . The assembly of modules onto each of the four barrel structures has recently been completed. In addition to functional tests made during the assembly process, each completed barrel was operated in its entirety. In the case of the largest barrel, with an active silicon area of approximately 10m 2 , this corresponds to more than one million instrumented channels. This paper documents the electrical performance of the four individual SCT barrels. An overview of the readout chain is also given

  17. Structural Basis for Substrate Specificity in Phosphate Binding (β/α)8-Barrels: D-Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12†

    OpenAIRE

    Chan, Kui K.; Fedorov, Alexander A.; Fedorov, Elena V.; Almo, Steven C.; Gerlt, John A.

    2008-01-01

    Enzymes that share the (β/α)8-barrel fold catalyze a diverse range of reactions. Many utilize phosphorylated substrates and share a conserved C-terminal (β/α)2-quarter barrel subdomain that provides a binding motif for the dianionic phosphate group. We recently reported functional and structural studies of D-ribulose 5-phosphate 3-epimerase (RPE) from Streptococcus pyogenes that catalyzes the equilibration of the pentulose 5-phosphates D-ribulose 5-phosphate and D-xylulose 5-phosphate in the ...

  18. Barrels XXX meeting report: Barrels in Baltimore.

    Science.gov (United States)

    Shin, Hyeyoung; Bitzidou, Malamati; Palaguachi, Fernando; Brumberg, Joshua C

    2018-03-01

    The Barrels meeting annually brings together researchers focused on the rodent whisker to cortical barrel system prior to the Society for Neuroscience meeting. The 2017 meeting focused on the classification of cortical interneurons, the role interneurons have in shaping brain dynamics, and finally on the circuitry underlying oral sensations. The meeting highlighted the latest advancements in this rapidly advancing field.

  19. Adjustable internal structure for reconstructing gradient index profile of crystalline lens.

    Science.gov (United States)

    Bahrami, Mehdi; Goncharov, Alexander V; Pierscionek, Barbara K

    2014-03-01

    Employing advanced technologies in studying the crystalline lens of the eye has improved our understanding of the refractive index gradient of the lens. Reconstructing and studying such a complex structure requires models with adaptable internal geometry that can be altered to simulate geometrical and optical changes of the lens with aging. In this Letter, we introduce an optically well-defined, geometrical structure for modeling the gradient refractive index profile of the crystalline lens with the advantage of an adjustable internal structure that is not available with existing models. The refractive index profile assigned to this rotationally symmetric geometry is calculated numerically, yet it is shown that this does not limit the model. The study provides a basis for developing lens models with sophisticated external and internal structures without the need for analytical solutions to calculate refractive index profiles.

  20. Structure of Rhodococcus equi virulence-associated protein B (VapB) reveals an eight-stranded antiparallel β-barrel consisting of two Greek-key motifs

    International Nuclear Information System (INIS)

    The structure of VapB, a member of the Vap protein family that is involved in virulence of the bacterial pathogen R. equi, was determined by SAD phasing and reveals an eight-stranded antiparallel β-barrel similar to avidin, suggestive of a binding function. Made up of two Greek-key motifs, the topology of VapB is unusual or even unique. Members of the virulence-associated protein (Vap) family from the pathogen Rhodococcus equi regulate virulence in an unknown manner. They do not share recognizable sequence homology with any protein of known structure. VapB and VapA are normally associated with isolates from pigs and horses, respectively. To contribute to a molecular understanding of Vap function, the crystal structure of a protease-resistant VapB fragment was determined at 1.4 Å resolution. The structure was solved by SAD phasing employing the anomalous signal of one endogenous S atom and two bound Co ions with low occupancy. VapB is an eight-stranded antiparallel β-barrel with a single helix. Structural similarity to avidins suggests a potential binding function. Unlike other eight- or ten-stranded β-barrels found in avidins, bacterial outer membrane proteins, fatty-acid-binding proteins and lysozyme inhibitors, Vaps do not have a next-neighbour arrangement but consist of two Greek-key motifs with strand order 41238567, suggesting an unusual or even unique topology

  1. Structure of Rhodococcus equi virulence-associated protein B (VapB) reveals an eight-stranded antiparallel β-barrel consisting of two Greek-key motifs

    Energy Technology Data Exchange (ETDEWEB)

    Geerds, Christina [Bielefeld University, Universitaetsstrasse 25, 33615 Bielefeld (Germany); Wohlmann, Jens; Haas, Albert [University of Bonn, Ulrich-Haberland Strasse 61a, 53121 Bonn (Germany); Niemann, Hartmut H., E-mail: hartmut.niemann@uni-bielefeld.de [Bielefeld University, Universitaetsstrasse 25, 33615 Bielefeld (Germany)

    2014-06-18

    The structure of VapB, a member of the Vap protein family that is involved in virulence of the bacterial pathogen R. equi, was determined by SAD phasing and reveals an eight-stranded antiparallel β-barrel similar to avidin, suggestive of a binding function. Made up of two Greek-key motifs, the topology of VapB is unusual or even unique. Members of the virulence-associated protein (Vap) family from the pathogen Rhodococcus equi regulate virulence in an unknown manner. They do not share recognizable sequence homology with any protein of known structure. VapB and VapA are normally associated with isolates from pigs and horses, respectively. To contribute to a molecular understanding of Vap function, the crystal structure of a protease-resistant VapB fragment was determined at 1.4 Å resolution. The structure was solved by SAD phasing employing the anomalous signal of one endogenous S atom and two bound Co ions with low occupancy. VapB is an eight-stranded antiparallel β-barrel with a single helix. Structural similarity to avidins suggests a potential binding function. Unlike other eight- or ten-stranded β-barrels found in avidins, bacterial outer membrane proteins, fatty-acid-binding proteins and lysozyme inhibitors, Vaps do not have a next-neighbour arrangement but consist of two Greek-key motifs with strand order 41238567, suggesting an unusual or even unique topology.

  2. Genetic structure of the Caribbean giant barrel sponge Xestospongia muta using the I3-M11 partition of COI

    Science.gov (United States)

    López-Legentil, S.; Pawlik, J. R.

    2009-03-01

    In recent years, reports of sponge bleaching, disease, and subsequent mortality have increased alarmingly. Population recovery may depend strongly on colonization capabilities of the affected species. The giant barrel sponge Xestospongia muta is a dominant reef constituent in the Caribbean. However, little is known about its population structure and gene flow. The 5'-end fragment of the mitochondrial gene cytochrome oxidase subunit I is often used to address these kinds of questions, but it presents very low intraspecific nucleotide variability in sponges. In this study, the usefulness of the I3-M11 partition of COI to determine the genetic structure of X. muta was tested for seven populations from Florida, the Bahamas and Belize. A total of 116 sequences of 544 bp were obtained for the I3-M11 partition corresponding to four haplotypes. In order to make a comparison with the 5'-end partition, 10 sequences per haplotype were analyzed for this fragment. The 40 resulting sequences were of 569 bp and corresponded to two haplotypes. The nucleotide diversity of the I3-M11 partition (π = 0.00386) was higher than that of the 5'-end partition (π = 0.00058), indicating better resolution at the intraspecific level. Sponges with the most divergent external morphologies (smooth vs. digitate surface) had different haplotypes, while those with the most common external morphology (rough surface) presented a mixture of haplotypes. Pairwise tests for genetic differentiation among geographic locations based on F ST values showed significant genetic divergence between most populations, but this genetic differentiation was not due to isolation by distance. While limited larval dispersal may have led to differentiation among some of the populations, the patterns of genetic structure appear to be most strongly related to patterns of ocean currents. Therefore, hydrological features may play a major role in sponge colonization and need to be considered in future plans for management and

  3. Injection barrel with a tapered structure for a low speed and small size cryogenic hydrogen pellet in medium-sized plasma fusion devices

    Science.gov (United States)

    Motojima, G.; Sakamoto, R.; Okada, H.; Nagasaki, K.; Yamada, H.; Nakamura, Y.; Kado, S.; Kobayashi, S.; Konoshima, S.; Minami, T.; Ohshima, S.; Yamamoto, S.; Mizuuchi, T.; Mutoh, T.

    2016-10-01

    An injection barrel was designed and fabricated for a small size 0.8 mm cryogenic pellet with a low speed of 200-300 m/s in medium-sized plasma fusion devices. Pellet injection with pneumatic acceleration was examined using a conventional in situ technique. A tapered structure was applied in the downstream side of the injection barrel to satisfy the requirement of pellet speed reduction by expansion of the propellant gas. Shadowgraph and light gate measurements show that the intact pellets have speeds of 260 ± 30 m/s and a typical size of 1.1-1.2 mm. The pellet ablation code based on a neutral gas shielding model shows that the penetration depth of the measured pellet parameters does not cross the plasma center, even in medium-sized plasma devices such as the Heliotron J helical device. The injection barrel with a tapered structure developed in this study is feasible for low speed pellet injection.

  4. D-Ribulose 5-Phosphate 3-Epimerase: Functional and Structural Relationships to Members of the Ribulose-Phosphate Binding (beta/alpha)8-Barrel Superfamily

    International Nuclear Information System (INIS)

    Akana, J.; Federov, A.; Federov, E.; Novak, W.; Babbitt, P.; Almo, S.; Gerlt, J.

    2006-01-01

    The 'ribulose phosphate binding' superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of divergent evolution from a common (β/α) 8 -barrel ancestor. The superfamily includes D-ribulose 5-phosphate 3-epimerase (RPE), orotidine 5'-monophosphate decarboxylase (OMPDC), and 3-keto-L-gulonate 6-phosphate decarboxylase (KGPDC), members of the OMPDC suprafamily, as well as enzymes involved in histidine and tryptophan biosynthesis that utilize phosphorylated metabolites as substrates. We now report studies of the functional and structural relationships of RPE to the members of the superfamily. As suggested by the results of crystallographic studies of the RPEs from rice and Plasmodium falciparum, the RPE from Streptococcus pyogenes is activated by Zn 2+ which binds with a stoichiometry of one ion per polypeptide. Although wild type RPE has a high affinity for Zn 2+ and inactive apoenzyme cannot be prepared, the affinity for Zn 2+ is decreased by alanine substitutions for the two histidine residues that coordinate the Zn 2+ ion (H34A and H67A); these mutant proteins can be prepared in an inactive, metal-free form and activated by exogenous Zn 2+ . The crystal structure of the RPE was solved at 1.8 Angstroms resolution in the presence of D-xylitol 5-phosphate, an inert analogue of the D-xylulose 5-phosphate substrate. This structure suggests that the 2,3-enediolate intermediate in the 1,1-proton transfer reaction is stabilized by bidentate coordination to the Zn 2+ that also is liganded to His 34, Asp 36, His 67, and Asp 176; the carboxylate groups of the Asp residues are positioned also to function as the acid/base catalysts. Although the conformation of the bound analogue resembles those of ligands bound in the active sites of OMPDC and KGPDC, the identities of the active site residues that coordinate the essential Zn 2+ and participate as acid/base catalysts are not conserved. We conclude that only the phosphate

  5. A peculiar lens-shaped structure observed in the South China Sea.

    Science.gov (United States)

    Lin, Hongyang; Hu, Jianyu; Liu, Zhiyu; Belkin, Igor M; Sun, Zhenyu; Zhu, Jia

    2017-03-28

    Lens-shaped structures within thermocline potentially play a significant role in subsurface transport of mass, heat, and salt in the global ocean. Whilst such structures have been documented in many oceanic regions, none has been observed in the China Seas. This study reports on observations of a lens-shaped structure within thermocline in the southwestern South China Sea in September 2007. This structure had a maximum thickness of approximately 60 m and a horizontal extent exceeding 220 km. This lens was peculiar in that its size is larger than most similar structures documented in the literature. The lens core was characterized by well-mixed water with higher temperature (~28.8 °C), lower salinity (~33.3) and lower potential vorticity (PV) compared to the surrounding waters. Based on an ocean reanalysis, possible generation mechanism of the lens is explored by examining the evolution of surface and subsurface thermohaline properties, and an analysis of vertical PV flux. The lens was likely generated by a mixture of the local mixed-layer water and the water from the coastal jet separation site.

  6. Prototyping the PANDA Barrel DIRC

    Energy Technology Data Exchange (ETDEWEB)

    Schwarz, C., E-mail: C.Schwarz@gsi.de [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Kalicy, G.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Hohler, R.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwiening, J.; Traxler, M.; Zühlsdorf, M. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Dodokhov, V.Kh. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Britting, A.; Eyrich, W.; Lehmann, A. [Friedrich Alexander-University of Erlangen-Nuremberg, Erlangen (Germany); and others

    2014-12-01

    The design of the Barrel DIRC detector for the future PANDA experiment at FAIR contains several important improvements compared to the successful BABAR DIRC, such as focusing and fast timing. To test those improvements as well as other design options a prototype was build and successfully tested in 2012 with particle beams at CERN. The prototype comprises a radiator bar, focusing lens, mirror, and a prism shaped expansion volume made of synthetic fused silica. An array of micro-channel plate photomultiplier tubes measures the location and arrival time of the Cherenkov photons with sub-nanosecond resolution. The development of a fast reconstruction algorithm allowed to tune construction details of the detector setup with test beam data and Monte-Carlo simulations.

  7. The Structure of a BamA-BamD Fusion Illuminates the Architecture of the β-Barrel Assembly Machine Core.

    Science.gov (United States)

    Bergal, Hans Thor; Hopkins, Alex Hunt; Metzner, Sandra Ines; Sousa, Marcelo Carlos

    2016-02-02

    The β-barrel assembly machine (BAM) mediates folding and insertion of integral β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria. Of the five BAM subunits, only BamA and BamD are essential for cell viability. Here we present the crystal structure of a fusion between BamA POTRA4-5 and BamD from Rhodothermus marinus. The POTRA5 domain binds BamD between its tetratricopeptide repeats 3 and 4. The interface structural elements are conserved in the Escherichia coli proteins, which allowed structure validation by mutagenesis and disulfide crosslinking in E. coli. Furthermore, the interface is consistent with previously reported mutations that impair BamA-BamD binding. The structure serves as a linchpin to generate a BAM model where POTRA domains and BamD form an elongated periplasmic ring adjacent to the membrane with a central cavity approximately 30 × 60 Å wide. We propose that nascent OMPs bind this periplasmic ring prior to insertion and folding by BAM. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. SCT Barrel Assembly Complete

    CERN Multimedia

    L. Batchelor

    As reported in the April 2005 issue of the ATLAS eNews, the first of the four Semiconductor Tracker (SCT) barrels, complete with modules and services, arrived safely at CERN in January of 2005. In the months since January, the other three completed barrels arrived as well, and integration of the four barrels into the entire barrel assembly commenced at CERN, in the SR1 building on the ATLAS experimental site, in July. Assembly was completed on schedule in September, with the addition of the innermost layer to the 4-barrel assembly. Work is now underway to seal the barrel thermal enclosure. This is necessary in order to enclose the silicon tracker in a nitrogen atmosphere and provide it with faraday-cage protection, and is a delicate and complicated task: 352 silicon module powertapes, 352 readout-fibre bundles, and over 400 Detector Control System sensors must be carefully sealed into the thermal enclosure bulkhead. The team is currently verifying the integrity of the low mass cooling system, which must be d...

  9. Micron-scale lens array having diffracting structures

    Science.gov (United States)

    Goldberg, Kenneth A

    2013-10-29

    A novel micron-scale lens, a microlens, is engineered to concentrate light efficiently onto an area of interest, such as a small, light-sensitive detector element in an integrated electronic device. Existing microlens designs imitate the form of large-scale lenses and are less effective at small sizes. The microlenses described herein have been designed to accommodate diffraction effects, which dominate the behavior of light at small length scales. Thus a new class of light-concentrating optical elements with much higher relative performance has been created. Furthermore, the new designs are much easier to fabricate than previous designs.

  10. Completion of the TRT Barrel

    CERN Multimedia

    Gagnon, P

    On February 3, the US-TRT team proudly completed the installation of the 96th barrel TRT module on its support structure in the SR building at CERN. This happy event came after many years of R&D initiated in the nineties by the TA1 team at CERN, followed by the construction of the modules in three American institutes (Duke, Hampton and Indiana Universities) from 1996 to 2003. In total, the 96 barrel modules contain 52544 kapton straws, each 4 mm in diameter and strung with a 30 micron gold-plated tungsten wire. Each wire was manually inserted, a feat in itself! The inner layer modules contain 329 straws, the middle layer modules have 520 straws and the outer layer, 793 straws. Thirty- two modules of each type form a full layer. Their special geometry was designed such as to leave no dead region. On average, a particle will cross 36 straws. Kirill Egorov, Chuck Mahlon and John Callahan inserted the last module in the Barrel Support Structure. After completion in the US, all modules were transferred...

  11. D-Ribulose 5-Phosphate 3-Epimerase: Functional and Structural Relationships to Members of the Ribulose-Phosphate Binding (beta/alpha)8-Barrel Superfamily

    Energy Technology Data Exchange (ETDEWEB)

    Akana,J.; Federov, A.; Federov, E.; Novak, W.; Babbitt, P.; Almo, S.; Gerlt, J.

    2006-01-01

    The 'ribulose phosphate binding' superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of divergent evolution from a common ({beta}/{alpha}){sub 8}-barrel ancestor. The superfamily includes D-ribulose 5-phosphate 3-epimerase (RPE), orotidine 5'-monophosphate decarboxylase (OMPDC), and 3-keto-L-gulonate 6-phosphate decarboxylase (KGPDC), members of the OMPDC suprafamily, as well as enzymes involved in histidine and tryptophan biosynthesis that utilize phosphorylated metabolites as substrates. We now report studies of the functional and structural relationships of RPE to the members of the superfamily. As suggested by the results of crystallographic studies of the RPEs from rice and Plasmodium falciparum, the RPE from Streptococcus pyogenes is activated by Zn{sup 2+} which binds with a stoichiometry of one ion per polypeptide. Although wild type RPE has a high affinity for Zn{sup 2+} and inactive apoenzyme cannot be prepared, the affinity for Zn{sup 2+} is decreased by alanine substitutions for the two histidine residues that coordinate the Zn{sup 2+} ion (H34A and H67A); these mutant proteins can be prepared in an inactive, metal-free form and activated by exogenous Zn{sup 2+}. The crystal structure of the RPE was solved at 1.8 Angstroms resolution in the presence of D-xylitol 5-phosphate, an inert analogue of the D-xylulose 5-phosphate substrate. This structure suggests that the 2,3-enediolate intermediate in the 1,1-proton transfer reaction is stabilized by bidentate coordination to the Zn{sup 2+} that also is liganded to His 34, Asp 36, His 67, and Asp 176; the carboxylate groups of the Asp residues are positioned also to function as the acid/base catalysts. Although the conformation of the bound analogue resembles those of ligands bound in the active sites of OMPDC and KGPDC, the identities of the active site residues that coordinate the essential Zn{sup 2+} and participate as acid/base catalysts

  12. Submicron hollow spot generation by solid immersion lens and structured illumination

    NARCIS (Netherlands)

    Kim, M.S.; Assafrao, A.C.; Scharf, T.; Wachters, A.J.H.; Pereira, S.F.; Urbach, H.P.; Brun, M.; Olivier, S.; Nicoletti, S.; Herzig, H.P.

    2012-01-01

    We report on the experimental and numerical demonstration of immersed submicron-size hollow focused spots, generated by structuring the polarization state of an incident light beam impinging on a micro-size solid immersion lens (?-SIL) made of SiO2. Such structured focal spots are characterized by a

  13. Material Structure of a Graded Refractive Index Lens in Decapod Squid

    Science.gov (United States)

    Cai, Jing; Heiney, Paul; Sweeney, Alison

    2013-03-01

    Underwater vision with a camera-type eye that is simultaneously acute and sensitive requires a spherical lens with a graded distribution of refractive index. Squids have this type of lens, and our previous work has shown that its optical properties are likely achieved with radially variable densities of a single protein with multiple isoforms. Here we measure the spatial organization of this novel protein material in concentric layers of the lens and use these data to suggest possible mechanisms of self-assembly of the proteins into a graded refractive index structure. First, we performed small angle x-ray scattering (SAXS) to study how the protein is spatially organized. Then, molecular dynamic simulation allowed us to correlate structure to the possible dynamics of the system in different regions of the lens. The combination of simulation and SAXS data in this system revealed the likely protein-protein interactions, resulting material structure and its relationship to the observed and variable optical properties of this graded index system. We believe insights into the material properties of the squid lens system will inform the invention of self-assembling graded index devices.

  14. The correct lens mount lightweighting design and thermal stress OPD analysis in Cassegrain telescope

    Science.gov (United States)

    Hsu, Ming-Ying; Chan, Chia-Yen; Lin, Wei-Cheng; Chang, Shenq-Tsong; Huang, Ting-Ming

    2013-09-01

    This study is trying to evaluate different lens barrel material, caused lens stress OPD (Optical Path Different) in different temperature condition. The Cassegrain telescope's correct lens assembly are including as correct lens, lens mount, spacer, mount barrel and retainer. The lens barrel initial design is made by invar, but system mass limit is need to lightweighting to meet requirement. Therefore, the lens barrel material is tried to replace to lower density material, such as aluminum and titanium alloy. Meanwhile, the aluminum or titanium alloy material properties CTE (Coefficient of Thermal Expansion) are larger then invar. Thus, the high CTE material will introduce larger thermal stress into the optical system in different temperature condition. This article is analysis the correct lens assembly thermal stress and optical performance in different lens mount material. From above conditions, using FEM (Finite Element Method) and optical software, simulation and optimization the lens mount to achieve system mass requirement.

  15. The TileCal Barrel Test Assembly

    CERN Multimedia

    Leitner, R

    On 30th October, the mechanics test assembly of the central barrel of the ATLAS tile hadronic calorimeter was completed in building 185. It started on 23rd June and is the second wheel for the Tilecal completely assembled this year. The ATLAS engineers and technicians are quick: instead of the 27 weeks initially foreseen for assembling the central barrel of the tile hadronic calorimeter (Tilecal) in building 185, they inserted the last of the 64 modules on 30th October after only 19 weeks. In part, this was due to the experience gained in the dry run assembly of the first extended barrel, produced in Spain, in spring this year (see Bulletin 23/2003); however, the central barrel is twice as long - and twice as heavy. With a length of 6.4 metres, an outer diameter of 8.5 metres and an inner diameter of 4.5 metres, the object weight is 1300 tonnes. The whole barrel cylinder is supported by the stainless steel support structure weighing only 27 tons. The barrel also has to have the right shape: over the whole 8...

  16. Structural and functional insights into the role of BamD and BamE within the β-barrel assembly machinery inNeisseria gonorrhoeae.

    Science.gov (United States)

    Sikora, Aleksandra E; Wierzbicki, Igor H; Zielke, Ryszard A; Ryner, Rachael F; Korotkov, Konstantin V; Buchanan, Susan K; Noinaj, Nicholas

    2018-01-26

    The β-barrel assembly machinery (BAM) is a conserved multicomponent protein complex responsible for the biogenesis of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria. Given its role in the production of OMPs for survival and pathogenesis, BAM represents an attractive target for the development of therapeutic interventions, including drugs and vaccines against multidrug-resistant bacteria such as Neisseria gonorrhoeae The first structure of BamA, the central component of BAM, was from N. gonorrhoeae , the etiological agent of the sexually transmitted disease gonorrhea. To aid in pharmaceutical targeting of BAM, we expanded our studies to BamD and BamE within BAM of this clinically relevant human pathogen. We found that the presence of BamD, but not BamE, is essential for gonococcal viability. However, BamE, but not BamD, was cell-surface-displayed under native conditions; however, in the absence of BamE, BamD indeed becomes surface-exposed. Loss of BamE altered cell envelope composition, leading to slower growth and an increase in both antibiotic susceptibility and formation of membrane vesicles containing greater amounts of vaccine antigens. Both BamD and BamE are expressed in diverse gonococcal isolates, under host-relevant conditions, and throughout different phases of growth. The solved structures of Neisseria BamD and BamE share overall folds with Escherichia coli proteins but contain differences that may be important for function. Together, these studies highlight that, although BAM is conserved across Gram-negative bacteria, structural and functional differences do exist across species, which may be leveraged in the development of species-specific therapeutics in the effort to combat multidrug resistance.

  17. Planar anisotropic Mikaelian lens on the basis of EBG-structure

    Science.gov (United States)

    Kaloshin, V. A.

    2016-09-01

    The problem on the synthesis of a planar Mikaelian lens in the form of layered metal-dielectric waveguide with a nonuniform anisotropic dielectric layer is solved. The problem is reduced to solution of the dispersion equations for E and H modes of a homogeneous layered waveguide. As an example of implementation of the solution obtained, the synthesis and analysis of the Mikaelian lens is carried out on the basis of the EBG structure in the form of a planar corrugated open and closed layered metal-dielectric waveguide. For a special case of the closed waveguide, the solution of the problem of synthesis for both polarizations is obtained explicitly.

  18. Fabrication of nano-structure anti-reflective lens using platinum nanoparticles in injection moulding

    International Nuclear Information System (INIS)

    Kurihara, K; Nakano, T; Saitou, Y; Kato, H; Souma, N; Makihara, S

    2015-01-01

    We provide a lens mould to attain an anti-reflection sub-wavelength structure (SWS) for plastic replica in the injection moulding process. To obtain the SWS on the lens mould, platinum nanoparticles formed by decomposition of a platinum oxide were employed. The fabricated platinum nanoparticles were estimated to be 90 nm in diameter, on average, and the dispersion of the particle diameter was evaluated to be ±20 nm. Through nanostructure replication by injection moulding, antireflection of less than 0.5% was achieved, and transmittance increased over 98%. In addition, a high-replication durability of over 10 000 times was attained. The variation of the minimum reflection ratio was evaluated to be 0.38% ± 0.04%. The usefulness of the proposed SWS mould for mass-production was confirmed, as it allows for high durability and SWS formation on the lens surface. (paper)

  19. A crystal barrel

    CERN Multimedia

    2007-01-01

    The production of crystals for the barrel of the CMS electromagnetic calorimeter has been completed. This is an important milestone for the experiment, which received the last of its 62,960 crystals on 9 March. The members of the team responsible for the crystal acceptance testing at CERN display the last crystal for the CMS electromagnetic calorimeter barrel. From left to right: Igor Tarasov, Etiennette Auffray and Hervé Cornet.One of the six machines specially developed to measure 67 different parameters on each crystal. Igor Tarasov is seen inserting the last batch of crystals into the machine. The last of the 62,960 CMS barrel crystals arrived at CERN on 9 March. Once removed from its polystyrene protection, this delicate crystal, like thousands of its predecessors, will be inserted into the last of the 36 supermodules of the barrel electromagnetic calorimeter in a few days' time. This marks the end of an important chapter in an almost 15-year-long journey by the CMS crystals team, some of whose member...

  20. Barrel Module0 Autopsy

    CERN Document Server

    Cobal, M; Nessi, Marzio; Blanch, O; Zamora, Y

    1999-01-01

    Using the information from the Cs calibration runs, many of the problems affecting the response of the barrel Module0 prototype have been spotted out. These can be bad fibre-tile couplings, light losses from fibres bundling, broken fibres, not transparent tiles etc. After a visual inspection, most of these problems have been repaired.

  1. LEAR Crystal Barrel Detector

    Energy Technology Data Exchange (ETDEWEB)

    Braune, K.; Keh, S.; Montanet, L.; Zoll, J.; Beckmann, R.; Friedrich, J.; Heinsius, H.; Kiel, T.; Lewendel, B.; Pegel, C.; and others

    1988-11-20

    The features of the Crystal Barrel Detector which is in preparation for LEAR at CERN, are discussed. The physics aims include q-barq- and exotics-spectroscopy and a detailed investigation of yet unknown p-barp-anihilation channels. An eventual later use on the PSI-B-Meson-Factory is discussed. The paper finishes with a description of the present status of the project.

  2. Structural basis for substrate specificity in phosphate binding (beta/alpha)8-barrels: D-allulose 6-phosphate 3-epimerase from Escherichia coli K-12.

    Science.gov (United States)

    Chan, Kui K; Fedorov, Alexander A; Fedorov, Elena V; Almo, Steven C; Gerlt, John A

    2008-09-09

    Enzymes that share the (beta/alpha) 8-barrel fold catalyze a diverse range of reactions. Many utilize phosphorylated substrates and share a conserved C-terminal (beta/alpha) 2-quarter barrel subdomain that provides a binding motif for the dianionic phosphate group. We recently reported functional and structural studies of d-ribulose 5-phosphate 3-epimerase (RPE) from Streptococcus pyogenes that catalyzes the equilibration of the pentulose 5-phosphates d-ribulose 5-phosphate and d-xylulose 5-phosphate in the pentose phosphate pathway [J. Akana, A. A. Fedorov, E. Fedorov, W. R. P. Novack, P. C. Babbitt, S. C. Almo, and J. A. Gerlt (2006) Biochemistry 45, 2493-2503]. We now report functional and structural studies of d-allulose 6-phosphate 3-epimerase (ALSE) from Escherichia coli K-12 that catalyzes the equilibration of the hexulose 6-phosphates d-allulose 6-phosphate and d-fructose 6-phosphate in a catabolic pathway for d-allose. ALSE and RPE prefer their physiological substrates but are promiscuous for each other's substrate. The active sites (RPE complexed with d-xylitol 5-phosphate and ALSE complexed with d-glucitol 6-phosphate) are superimposable (as expected from their 39% sequence identity), with the exception of the phosphate binding motif. The loop following the eighth beta-strand in ALSE is one residue longer than the homologous loop in RPE, so the binding site for the hexulose 6-phosphate substrate/product in ALSE is elongated relative to that for the pentulose 5-phosphate substrate/product in RPE. We constructed three single-residue deletion mutants of the loop in ALSE, DeltaT196, DeltaS197 and DeltaG198, to investigate the structural bases for the differing substrate specificities; for each, the promiscuity is altered so that d-ribulose 5-phosphate is the preferred substrate. The changes in k cat/ K m are dominated by changes in k cat, suggesting that substrate discrimination results from differential transition state stabilization. In both ALSE and RPE

  3. Structural Basis for Substrate Specificity in Phosphate Binding (β/α)8-Barrels: D-Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12†

    Science.gov (United States)

    Chan, Kui K.; Fedorov, Alexander A.; Fedorov, Elena V.; Almo, Steven C.; Gerlt, John A.

    2008-01-01

    Enzymes that share the (β/α)8-barrel fold catalyze a diverse range of reactions. Many utilize phosphorylated substrates and share a conserved C-terminal (β/α)2-quarter barrel subdomain that provides a binding motif for the dianionic phosphate group. We recently reported functional and structural studies of D-ribulose 5-phosphate 3-epimerase (RPE) from Streptococcus pyogenes that catalyzes the equilibration of the pentulose 5-phosphates D-ribulose 5-phosphate and D-xylulose 5-phosphate in the pentose phosphate pathway [J. Akana, A. A. Fedorov, E. Fedorov, W. R. P. Novack, P. C. Babbitt, S. C. Almo, and J. A. Gerlt (2006) Biochemistry 45, 2493–2503]. We now report functional and structural studies of D-allulose 6-phosphate 3-epimerase (ALSE) from Escherichia coli K-12 that catalyzes the equilibration of the hexulose 6-phosphates D-allulose 6-phosphate and D-fructose 6-phosphate in a catabolic pathway for D-allose. ALSE and RPE prefer their physiological substrates but are promiscuous for each other’s substrate. The active sites (RPE complexed with D-xylitol 5-phosphate and ALSE complexed with D-glucitol 6-phosphate) are superimposable (as expected from their 39% sequence identity), with the exception of the phosphate binding motif. The loop following the eighth β-strand in ALSE is one residue longer than the homologous loop in RPE, so the binding site for the hexulose 6-phosphate substrate/product in ALSE is elongated relative to that for the pentulose 5-phosphate substrate/product in RPE. We constructed three single-residue deletion mutants of the loop in ALSE, ΔT196, ΔS197 and ΔG198, to investigate the structural bases for the differing substrate specificities; for each, the promiscuity is altered so that D-ribulose 5-phosphate is the preferred substrate. The changes in kcat/Km are dominated by changes in kcat, suggesting that substrate discrimination results from differential transition state stabilization. In both ALSE and RPE, the phosphate group

  4. Structural Basis for Substrate Specificity in Phosphate Binding (beta/alpha)8-Barrels: D-Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12

    Energy Technology Data Exchange (ETDEWEB)

    Chan,K.; Fedorov, A.; Almo, S.; Gerlt, J.

    2008-01-01

    Enzymes that share the ({beta}/{alpha})8-barrel fold catalyze a diverse range of reactions. Many utilize phosphorylated substrates and share a conserved C-terminal ({beta}/a)2-quarter barrel subdomain that provides a binding motif for the dianionic phosphate group. We recently reported functional and structural studies of d-ribulose 5-phosphate 3-epimerase (RPE) from Streptococcus pyogenes that catalyzes the equilibration of the pentulose 5-phosphates d-ribulose 5-phosphate and d-xylulose 5-phosphate in the pentose phosphate pathway [J. Akana, A. A. Fedorov, E. Fedorov, W. R. P. Novack, P. C. Babbitt, S. C. Almo, and J. A. Gerlt (2006) Biochemistry 45, 2493-2503]. We now report functional and structural studies of d-allulose 6-phosphate 3-epimerase (ALSE) from Escherichia coli K-12 that catalyzes the equilibration of the hexulose 6-phosphates d-allulose 6-phosphate and d-fructose 6-phosphate in a catabolic pathway for d-allose. ALSE and RPE prefer their physiological substrates but are promiscuous for each other's substrate. The active sites (RPE complexed with d-xylitol 5-phosphate and ALSE complexed with d-glucitol 6-phosphate) are superimposable (as expected from their 39% sequence identity), with the exception of the phosphate binding motif. The loop following the eighth {beta}-strand in ALSE is one residue longer than the homologous loop in RPE, so the binding site for the hexulose 6-phosphate substrate/product in ALSE is elongated relative to that for the pentulose 5-phosphate substrate/product in RPE. We constructed three single-residue deletion mutants of the loop in ALSE, ?T196, ?S197 and ?G198, to investigate the structural bases for the differing substrate specificities; for each, the promiscuity is altered so that d-ribulose 5-phosphate is the preferred substrate. The changes in kcat/Km are dominated by changes in kcat, suggesting that substrate discrimination results from differential transition state stabilization. In both ALSE and RPE, the

  5. Microstructural evolution of the LENS manufactured TiAl structure

    CSIR Research Space (South Africa)

    Lengopeng, T

    2016-11-01

    Full Text Available The advent of additive manufacturing presented the new-era where complex structures can be prototype and rapidly manufactured from a computer aided device file. Robust industries such as the aerospace and medicinal require 3 D printed complex...

  6. Globally intertwined evolutionary history of giant barrel sponges

    NARCIS (Netherlands)

    Swierts, Thomas; Peijnenburg, Katja T.C.A.; Leeuw, de Christiaan A.; Breeuwer, Johannes A.J.; Cleary, Daniel F.R.; Voogd, de Nicole J.

    2017-01-01

    Three species of giant barrel sponge are currently recognized in two distinct geographic regions, the tropical Atlantic and the Indo-Pacific. In this study, we used molecular techniques to study populations of giant barrel sponges across the globe and assessed whether the genetic structure of these

  7. Patterns of population structure and dispersal in the long-lived "redwood" of the coral reef, the giant barrel sponge ( Xestospongia muta)

    Science.gov (United States)

    Richards, Vincent P.; Bernard, Andrea M.; Feldheim, Kevin A.; Shivji, Mahmood S.

    2016-09-01

    Sponges are one of the dominant fauna on Florida and Caribbean coral reefs, with species diversity often exceeding that of scleractinian corals. Despite the key role of sponges as structural components, habitat providers, and nutrient recyclers in reef ecosystems, their dispersal dynamics are little understood. We used ten microsatellite markers to study the population structure and dispersal patterns of a prominent reef species, the giant barrel sponge ( Xestospongia muta), the long-lived "redwood" of the reef, throughout Florida and the Caribbean. F-statistics, exact tests of population differentiation, and Bayesian multi-locus genotype analyses revealed high levels of overall genetic partitioning ( F ST = 0.12, P = 0.001) and grouped 363 individuals collected from the Bahamas, Honduras, US Virgin Islands, Key Largo (Florida), and the remainder of the Florida reef tract into at minimum five genetic clusters ( K = 5). Exact tests, however, revealed further differentiation, grouping sponges sampled from five locations across the Florida reef tract (~250 km) into three populations, suggesting a total of six genetic populations across the eight locations sampled. Assignment tests showed dispersal over ecological timescales to be limited to relatively short distances, as the only migration detected among populations was within the Florida reef tract. Consequently, populations of this major coral reef benthic constituent appear largely self-recruiting. A combination of levels of genetic differentiation, genetic distance, and assignment tests support the important role of the Caribbean and Florida currents in shaping patterns of contemporary and historical gene flow in this widespread coral reef species.

  8. Diamond Machining of Optical Structured Surfaces Using a Circular Fresnel Lens as an Example

    Directory of Open Access Journals (Sweden)

    S. V. Grubyi

    2017-01-01

    Full Text Available Components of optical systems for various purposes include optical elements with structured surfaces, i.e. linear and circular Fresnel lenses. The objective of the conducted studies is to analyse design parameters and technological development of modes and conditions to ensure manufacturing circular Fresnel lenses with specified technology requirements.The subject of the study is a circular Fresnel lens, which has a thickness of 2 mm and a diameter of 76.7 mm; its processed profile consists of 126 concentric rings with a valley pitch equal to 0.3 mm. The profile depth of the rings varies from 2.1μm to 337.4μm, with the profile angle varying from 0.406 ° to 48.361 °. The lens material is polymethyl methacrylate (PMMA - a tough amorphous polymer, which has high transparency, weather resistance, good physical-mechanical and electrical insulating properties.The article presents the results of applied research related to diamond machining of a Fresnel circular lens. Substantiates that there is a need to use an ultra-precise machine for lens processing and gives its main technical characteristics.The design features and recommended domestic and foreign diamond mono-crystalline cutters for preliminary and finishing processing of structured surfaces, including Fresnel lenses are analysed.The technology of diamond edge cutting machining of lenses is proposed, the modes and conditions of diamond turning to exclude finning are given.The results of metrological control have confirmed the requirements for the profile accuracy and the roughness of surfaces machined. The JSC "VNIIINSTRUMENT" has implemented the developed technology on the ultra-precise specialised NC machine and recommended its use in machining the structured plexiglass surfaces of various sizes for different purposes.

  9. Effects of lens extirpation with anterior vitrectomy on vitreous three-dimensional mesh structure

    Directory of Open Access Journals (Sweden)

    Yan Zhao

    2017-06-01

    Full Text Available AIM: To investigate the changes in vitreous gel structure after lens extirpation combined with anterior vitrectomy in rabbit eyes. METHODS: Twenty-eight chinchilla rabbits were divided into three groups. The control group (Group I included 16 eyes from eight rabbits who did not receive any treatment. Group II included 20 eyes from 10 rabbits that underwent lens aspiration only. Group III included 20 eyes from 10 rabbits that underwent lens aspiration combined with posterior capsulotomy and anterior vitrectomy. Eyes were harvested on the 30th and 60th day postoperatively, respectively. Changes in vitreous gel stretch length due to gravity and the rate of vitreous liquefaction were observed. The collagen content in the vitreous body was examined using the L-hydroxyproline test. Electronic microscopic images were obtained from each eyeball. RESULTS: On both the 30th and 60th day postoperatively, the vitreous gel length of group III was significantly shorter than group I and group II (P<0.05, while the rate of liquefaction of the vitreous body in group III was significantly higher than group I and group II (P<0.05. The collagen content in group III was also higher than that in group I and group II (P<0.05. CONCLUSION: Loss of vitreous gel mass is more likely to occur in the eyes of rabbits receiving anterior vitrectomy. Lensectomy combined with anterior vitrectomy may damage the stable three-dimensional mesh structure of collagen, which could aggravate vitreous gel liquefaction.

  10. Influence of Go-like interactions on global shapes of energy landscapes in beta-barrel forming model proteins: inherent structure analysis and statistical temperature molecular dynamics simulation.

    Science.gov (United States)

    Kim, Jaegil; Keyes, Thomas

    2008-01-24

    Recently, the native-centric, coarse-grained "Go-like" protein model has gained a renewed popularity because of its computational simplicity and successful description of some key aspects of folding thermodynamics and kinetics. In the present paper, the properties of Go-like models are investigated in terms of the potential energy landscape (PEL). The non-native attractions of the beta-barrel forming BLN model 46-mer are scaled with a parameter 0 Go-like interactions brings about a significant modification in the occupation of low-lying IS by destabilizing the misfolding funnel into a higher energy region, strongly influencing the folding thermodynamics. The alteration of the PEL also induces a dramatic change in the folding mechanism, from a second-order-like collapse transition into a cooperative, first-order-like folding transition, occurring through a transient, intermediate state ensemble characterized by partially structured IS. The appearance of multiple van der Waals loops in the statistical temperature of the Go-like model is associated with the development of the intermediate states.

  11. Correcting the Chromatic Aberration in Barrel Distortion of Endoscopic Images

    Directory of Open Access Journals (Sweden)

    Y. M. Harry Ng

    2003-04-01

    Full Text Available Modern endoscopes offer physicians a wide-angle field of view (FOV for minimally invasive therapies. However, the high level of barrel distortion may prevent accurate perception of image. Fortunately, this kind of distortion may be corrected by digital image processing. In this paper we investigate the chromatic aberrations in the barrel distortion of endoscopic images. In the past, chromatic aberration in endoscopes is corrected by achromatic lenses or active lens control. In contrast, we take a computational approach by modifying the concept of image warping and the existing barrel distortion correction algorithm to tackle the chromatic aberration problem. In addition, an error function for the determination of the level of centroid coincidence is proposed. Simulation and experimental results confirm the effectiveness of our method.

  12. Evolution of Substrate Specificity within a Diverse Family of [beta/alpha]-Barrel-fold Basic Amino Acid Decarboxylases X-ray Structure Determination of Enzymes with Specificity for L-Arginine and Carboxynorspermidine

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Xiaoyi; Lee, Jeongmi; Michael, Anthony J.; Tomchick, Diana R.; Goldsmith, Elizabeth J.; Phillips, Margaret A. (Sungkyunkwan); (UTSMC)

    2010-08-26

    Pyridoxal 5{prime}-phosphate (PLP)-dependent basic amino acid decarboxylases from the {beta}/{alpha}-barrel-fold class (group IV) exist in most organisms and catalyze the decarboxylation of diverse substrates, essential for polyamine and lysine biosynthesis. Herein we describe the first x-ray structure determination of bacterial biosynthetic arginine decarboxylase (ADC) and carboxynorspermidine decarboxylase (CANSDC) to 2.3- and 2.0-{angstrom} resolution, solved as product complexes with agmatine and norspermidine. Despite low overall sequence identity, the monomeric and dimeric structures are similar to other enzymes in the family, with the active sites formed between the {beta}/{alpha}-barrel domain of one subunit and the {beta}-barrel of the other. ADC contains both a unique interdomain insertion (4-helical bundle) and a C-terminal extension (3-helical bundle) and it packs as a tetramer in the asymmetric unit with the insertions forming part of the dimer and tetramer interfaces. Analytical ultracentrifugation studies confirmed that the ADC solution structure is a tetramer. Specificity for different basic amino acids appears to arise primarily from changes in the position of, and amino acid replacements in, a helix in the {beta}-barrel domain we refer to as the 'specificity helix.' Additionally, in CANSDC a key acidic residue that interacts with the distal amino group of other substrates is replaced by Leu{sup 314}, which interacts with the aliphatic portion of norspermidine. Neither product, agmatine in ADC nor norspermidine in CANSDC, form a Schiff base to pyridoxal 5{prime}-phosphate, suggesting that the product complexes may promote product release by slowing the back reaction. These studies provide insight into the structural basis for the evolution of novel function within a common structural-fold.

  13. The structural alteration and aggregation propensity of glycated lens crystallins in the presence of calcium: Importance of lens calcium homeostasis in development of diabetic cataracts

    Science.gov (United States)

    ZM, Sara Zafaranchi; Khoshaman, Kazem; Masoudi, Raheleh; Hemmateenejad, Bahram; Yousefi, Reza

    2017-01-01

    The imbalance of the calcium homeostasis in the lenticular tissues of diabetic patients is an important risk factor for development of cataract diseases. In the current study, the impact of elevated levels of calcium ions were investigated on structure and aggregation propensity of glycated lens crystallins using gel electrophoresis and spectroscopic assessments. The glycated proteins indicated significant resistance against calcium-induced structural insults and aggregation. While, glycated crystallins revealed an increased conformational stability; a slight instability was observed for these proteins upon interaction with calcium ions. Also, in the presence of calcium, the proteolytic pattern of native crystallins was altered and that of glycated protein counterparts remained almost unchanged. According to results of this study it is suggested that the structural alteration of lens crystallins upon glycation may significantly reduce their calcium buffering capacity in eye lenses. Therefore, under chronic hyperglycemia accumulation of this cataractogenic metal ion in the lenticular tissues may subsequently culminate in activation of different pathogenic pathways, leading to development of lens opacity and cataract diseases.

  14. The oil barrel price

    International Nuclear Information System (INIS)

    Blondy, J.; Papon, P.

    2009-01-01

    This paper proposes an overview and a prospective glance on the oil barrel price. It indicates the relevant indicators: Brent quotation, euro/dollar parity, economic activity indicators, world oil consumption distribution, crude oil production, refining capacity. It briefly presents the involved stake holders: crude oil producers, oil refiners, refined product dealers, and the OPEC. It discusses the major retrospective trends: evolution in relationship with geopolitical events and energy policies, strong correlation between oil demand and economic growth, prevalence of OPEC, growing importance of national oil companies. An emerging trend is noticed: growing role of emerging countries on the crude market. Some prospective issues are discussed: duration and intensity of economic recession, separation between economic growth and energy consumption, pace and ambition level of policies of struggle against climate change, exploitable resources, and geopolitical hazards. Four evolution hypotheses are discussed

  15. Submicron hollow spot generation by solid immersion lens and structured illumination

    International Nuclear Information System (INIS)

    Kim, M-S; Scharf, T; Herzig, H P; Assafrao, A C; Wachters, A J H; Pereira, S F; Urbach, H P; Brun, M; Olivier, S; Nicoletti, S

    2012-01-01

    We report on the experimental and numerical demonstration of immersed submicron-size hollow focused spots, generated by structuring the polarization state of an incident light beam impinging on a micro-size solid immersion lens (μ-SIL) made of SiO 2 . Such structured focal spots are characterized by a doughnut-shaped intensity distribution, whose central dark region is of great interest for optical trapping of nano-size particles, super-resolution microscopy and lithography. In this work, we have used a high-resolution interference microscopy technique to measure the structured immersed focal spots, whose dimensions were found to be significantly reduced due to the immersion effect of the μ-SIL. In particular, a reduction of 37% of the dark central region was verified. The measurements were compared with a rigorous finite element method model for the μ-SIL, revealing excellent agreement between them. (paper)

  16. Barrel calorimeter of the CMD-3 detector

    International Nuclear Information System (INIS)

    Shebalin, V. E.; Anisenkov, A. V.; Aulchenko, V. M.; Bashtovoy, N. S.; Epifanov, D. A.; Epshteyn, L. B.; Grebenuk, A. A.; Ignatov, F. V.; Erofeev, A. L.; Kovalenko, O. A.; Kozyrev, A. N.; Kuzmin, A. S.; Logashenko, I. B.; Mikhailov, K. Yu.; Razuvaev, G. P.; Ruban, A. A.; Shwartz, B. A.; Talyshev, A. A.; Titov, V. M.; Yudin, Yu. V.

    2015-01-01

    The structure of the barrel calorimeter of the CMD-3 detector is presented in this work. The procedure of energy calibration of the calorimeter and the method of photon energy restoration are described. The distinctive feature of this barrel calorimeter is its combined structure; it is composed of two coaxial subsystems: a liquid xenon calorimeter and a crystalline CsI calorimeter. The calorimeter spatial resolution of the photon conversion point is about 2 mm, which corresponds to an angular resolution of ∼6 mrad. The energy resolution of the calorimeter is about 8% for photons with energy of 200 MeV and 4% for photons with energy of 1 GeV

  17. The PANDA Barrel DIRC

    Science.gov (United States)

    Dzhygadlo, R.; Schwarz, C.; Belias, A.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Britting, A.; Eyrich, W.; Lehmann, A.; Pfaffinger, M.; Uhlig, F.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Schmidt, M.; Cowie, E.; Keri, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

    2016-05-01

    The PANDA detector at the international accelerator Facility for Antiproton and Ion Research in Europe (FAIR) addresses fundamental questions of hadron physics. Experiments concerning charmonium spectroscopy, the search for hybrids and glueballs and the interaction of hidden and open charm particles with nucleons and nuclei will be performed with antiproton beams impinging on hydrogen or nuclear targets. Cooled beams allow the precision scan of resonances in formation experiments. The momentum range of the antiproton beam between 1.5 GeV/c and 15 GeV/c tests predictions by perturbation theory and will reveal deviations originating from strong QCD . An excellent hadronic particle identification will be accomplished by DIRC (Detection of Internally Reflected Cherenkov light) counters. The design for the barrel region is based on the successful BaBar DIRC with several key improvements, such as fast photon timing and a compact imaging region. DIRC designs based on different radiator geometries with several focusing options were studied in simulation. The performance of each design was characterized in terms of photon yield and single photon Cherenkov angle resolution. Selected design options were implemented in prototypes and tested with hadronic particle beams at GSI and CERN.

  18. Double-barreled wet colostomy: urinary and fecal diversion.

    Science.gov (United States)

    Kecmanovic, Dragutin M; Pavlov, Maja J; Ceranic, Miljan S; Masulovic, Dragan M; Popov, Ivan P; Micev, Marjan T

    2008-07-01

    Double-barreled wet colostomy represents simultaneous urinary and fecal surgical diversion performed most commonly after pelvic exenteration as a palliative procedure or after actinic damage. We report the structural and functional results of double-barreled wet colostomy with special attention to surgical technique, morbidity and functional results compared to those described in the available literature. We retrospectively followed 38 patients who underwent double-barreled wet colostomy at our institution from April 2003 to November 2007. The parameters were patient age and gender, the indication for double-barreled wet colostomy, postoperative morbidity and mortality, length of hospital stay and functional assessment by excreting excretory urography. A total of 38 double-barreled wet colostomies were performed at our institution, including 24 following total pelvic exenteration, 14 without resection, 9 in inoperable tumor cases and 5 in actinic damage cases. The postoperative morbidity rate was 15.7% with no treatment related mortality. Two patients had late postoperative complications, including stenosis of the ureterocolonic anastomosis and conduit necrosis, respectively. In our experience double-barreled wet colostomy has an acceptable morbidity and mortality rate, is performed without technical difficulties and does not require prolonged operative time. Double-barreled wet colostomy represents the procedure of choice in patients who require concurrent urinary and fecal diversion.

  19. Structure and dynamics of the fish eye lens protein, γM7-crystallin.

    Science.gov (United States)

    Mahler, Bryon; Chen, Yingwei; Ford, Jason; Thiel, Caleb; Wistow, Graeme; Wu, Zhengrong

    2013-05-21

    The vertebrate eye lens contains high concentrations of crystallins. The dense lenses of fish are particularly abundant in a class called γM-crystallin whose members are characterized by an unusually high methionine content and partial loss of the four tryptophan residues conserved in all γ-crystallins from mammals which are proposed to contribute to protection from UV-damage. Here, we present the structure and dynamics of γM7-crystallin from zebrafish (Danio rerio). The solution structure shares the typical two-domain, four-Greek-key motif arrangement of other γ-crystallins, with the major difference noted in the final loop of the N-terminal domain, spanning residues 65-72. This is likely due to the absence of the conserved tryptophans. Many of the methionine residues are exposed on the surface but are mostly well-ordered and frequently have contacts with aromatic side chains. This may contribute to the specialized surface properties of these proteins that exist under high molecular crowding in the fish lens. NMR relaxation data show increased backbone conformational motions in the loop regions of γM7 compared to those of mouse γS-crystallin and show that fast internal motion of the interdomain linker in γ-crystallins correlates with linker length. Unfolding studies monitored by tryptophan fluorescence confirm results from mutant mouse γS-crystallin and show that unfolding of a βγ-crystallin domain likely starts from unfolding of the variable loop containing the more fluorescently quenched tryptophan residue, resulting in a native-like unfolding intermediate.

  20. The ATLAS TRT Barrel Detector

    Science.gov (United States)

    ATLAS TRT Collaboration; Abat, E.; Addy, T. N.; Åkesson, T. P. A.; Alison, J.; Anghinolfi, F.; Arik, E.; Arik, M.; Atoian, G.; Auerbach, B.; Baker, O. K.; Banas, E.; Baron, S.; Bault, C.; Becerici, N.; Beddall, A.; Beddall, A. J.; Bendotti, J.; Benjamin, D. P.; Bertelsen, H.; Bingul, A.; Blampey, H.; Bocci, A.; Bochenek, M.; Bondarenko, V. G.; Bychkov, V.; Callahan, J.; Capeáns Garrido, M.; Cardiel Sas, L.; Catinaccio, A.; Cetin, S. A.; Chandler, T.; Chritin, R.; Cwetanski, P.; Dam, M.; Danielsson, H.; Danilevich, E.; David, E.; Degenhardt, J.; Di Girolamo, B.; Dittus, F.; Dixon, N.; Dogan, O. B.; Dolgoshein, B. A.; Dressnandt, N.; Driouchi, C.; Ebenstein, W. L.; Eerola, P.; Egede, U.; Egorov, K.; Evans, H.; Farthouat, P.; Fedin, O. L.; Fowler, A. J.; Fratina, S.; Froidevaux, D.; Fry, A.; Gagnon, P.; Gavrilenko, I. L.; Gay, C.; Ghodbane, N.; Godlewski, J.; Goulette, M.; Gousakov, I.; Grigalashvili, N.; Grishkevich, Y.; Grognuz, J.; Hajduk, Z.; Hance, M.; Hansen, F.; Hansen, J. B.; Hansen, P. H.; Hanson, G.; Hare, G. A.; Harvey, A., Jr.; Hauviller, C.; High, A.; Hulsbergen, W.; Huta, W.; Issakov, V.; Istin, S.; Jain, V.; Jarlskog, G.; Jeanty, L.; Kantserov, V. A.; Kaplan, B.; Kapliy, A. S.; Katounine, S.; Kayumov, F.; Keener, P. T.; Kekelidze, G. D.; Khabarova, E.; Khristachev, A.; Kisielewski, B.; Kittelmann, T. H.; Kline, C.; Klinkby, E. B.; Klopov, N. V.; Ko, B. R.; Koffas, T.; Kondratieva, N. V.; Konovalov, S. P.; Koperny, S.; Korsmo, H.; Kovalenko, S.; Kowalski, T. Z.; Krüger, K.; Kramarenko, V.; Kudin, L. G.; LeBihan, A.-C.; LeGeyt, B. C.; Levterov, K.; Lichard, P.; Lindahl, A.; Lisan, V.; Lobastov, S.; Loginov, A.; Loh, C. W.; Lokwitz, S.; Long, M. C.; Lucas, S.; Lucotte, A.; Luehring, F.; Lundberg, B.; Mackeprang, R.; Maleev, V. P.; Manara, A.; Mandl, M.; Martin, A. J.; Martin, F. F.; Mashinistov, R.; Mayers, G. M.; McFarlane, K. W.; Mialkovski, V.; Mills, B. M.; Mindur, B.; Mitsou, V. A.; Mjörnmark, J. U.; Morozov, S. V.; Morris, E.; Mouraviev, S. V.; Muir, A. M.; Munar, A.; Nadtochi, A. V.; Nesterov, S. Y.; Newcomer, F. M.; Nikitin, N.; Novgorodova, O.; Novodvorski, E. G.; Ogren, H.; Oh, S. H.; Oleshko, S. B.; Olivito, D.; Olszowska, J.; Ostrowicz, W.; Passmore, M. S.; Patrichev, S.; Penwell, J.; Perez-Gomez, F.; Peshekhonov, V. D.; Petersen, T. C.; Petti, R.; Placci, A.; Poblaguev, A.; Pons, X.; Price, M. J.; hne, O. Rø; Reece, R. D.; Reilly, M. B.; Rembser, C.; Romaniouk, A.; Rousseau, D.; Rust, D.; Ryabov, Y. F.; Ryjov, V.; Söderberg, M.; Savenkov, A.; Saxon, J.; Scandurra, M.; Schegelsky, V. A.; Scherzer, M. I.; Schmidt, M. P.; Schmitt, C.; Sedykh, E.; Seliverstov, D. M.; Shin, T.; Shmeleva, A.; Sivoklokov, S.; Smirnov, S. Yu; Smirnova, L.; Smirnova, O.; Smith, P.; Sosnovtsev, V. V.; Sprachmann, G.; Subramania, S.; Suchkov, S. I.; Sulin, V. V.; Szczygiel, R. R.; Tartarelli, G.; Thomson, E.; Tikhomirov, V. O.; Tipton, P.; Valls Ferrer, J. A.; Van Berg, R.; Vassilakopoulos, V. I.; Vassilieva, L.; Wagner, P.; Wall, R.; Wang, C.; Whittington, D.; Williams, H. H.; Zhelezko, A.; Zhukov, K.

    2008-02-01

    The ATLAS TRT barrel is a tracking drift chamber using 52,544 individual tubular drift tubes. It is one part of the ATLAS Inner Detector, which consists of three sub-systems: the pixel detector spanning the radius range 4 to 20 cm, the semiconductor tracker (SCT) from 30 to 52 cm, and the transition radiation tracker (TRT) from 56 to 108 cm. The TRT barrel covers the central pseudo-rapidity region |η|< 1, and the TRT while endcaps cover the forward and backward eta regions. These TRT systems provide a combination of continuous tracking with many measurements in individual drift tubes (or straws) and of electron identification based on transition radiation from fibers or foils interleaved between the straws themselves. This paper describes the recently-completed construction of the TRT Barrel detector, including the quality control procedures used in the fabrication of the detector.

  1. Robotic mounting of ATLAS barrel SCT modules

    International Nuclear Information System (INIS)

    Nickerson, R.B.; Viehhauser, G.; Wastie, R.; Terada, S.; Unno, Y.; Kohriki, T.; Ikegami, Y.; Hara, K.; Kobayashi, H.; Barbier, G.; Clark, A.G.; Perrin, E.; Carter, A.A.; Mistry, J.; Morris, J.

    2006-01-01

    The 2112 silicon detector modules of the barrel part of the ATLAS SemiConductor Tracker (SCT) have been mounted on their carbon fibre support structure. Module insertion, placement and fixing were performed by robotic assembly tooling. We report on our experience with this assembly method. Part of the mounting sequence involves a partial survey of elements of the support structure which is needed to align the modules properly during insertion. An analysis of these data is used to estimate the positional accuracy of the robots

  2. Recombinant production and solution structure of lipid transfer protein from lentil Lens culinaris

    International Nuclear Information System (INIS)

    Gizatullina, Albina K.; Finkina, Ekaterina I.; Mineev, Konstantin S.; Melnikova, Daria N.; Bogdanov, Ivan V.; Telezhinskaya, Irina N.; Balandin, Sergey V.; Shenkarev, Zakhar O.; Arseniev, Alexander S.; Ovchinnikova, Tatiana V.

    2013-01-01

    Highlights: •Lipid transfer protein from lentil seeds (Lc-LTP2) was overexpressed in E. coli. •Antimicrobial activity and spatial structure of the recombinant Lc-LTP2 were examined. •Internal tunnel-like lipid-binding cavity occupies ∼7% of the total Lc-LTP2 volume. •Binding of DMPG lipid induces moderate rearrangements in the Lc-LTP2 structure. •Lc-LTP2/DMPG complex has limited lifetime and dissociates within tens of hours. -- Abstract: Lipid transfer protein, designated as Lc-LTP2, was isolated from seeds of the lentil Lens culinaris. The protein has molecular mass 9282.7 Da, consists of 93 amino acid residues including 8 cysteines forming 4 disulfide bonds. Lc-LTP2 and its stable isotope labeled analogues were overexpressed in Escherichia coli and purified. Antimicrobial activity of the recombinant protein was examined, and its spatial structure was studied by NMR spectroscopy. The polypeptide chain of Lc-LTP2 forms four α-helices (Cys4-Leu18, Pro26-Ala37, Thr42-Ala56, Thr64-Lys73) and a long C-terminal tail without regular secondary structure. Side chains of the hydrophobic residues form a relatively large internal tunnel-like lipid-binding cavity (van der Waals volume comes up to ∼600 Å 3 ). The side-chains of Arg45, Pro79, and Tyr80 are located near an assumed mouth of the cavity. Titration with dimyristoyl phosphatidylglycerol (DMPG) revealed formation of the Lc-LTP2/lipid non-covalent complex accompanied by rearrangements in the protein spatial structure and expansion of the internal cavity. The resultant Lc-LTP2/DMPG complex demonstrates limited lifetime and dissociates within tens of hours

  3. Mapping the structure of folding cores in TIM barrel proteins by hydrogen exchange mass spectrometry: the roles of motif and sequence for the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus.

    Science.gov (United States)

    Gu, Zhenyu; Zitzewitz, Jill A; Matthews, C Robert

    2007-04-27

    To test the roles of motif and amino acid sequence in the folding mechanisms of TIM barrel proteins, hydrogen-deuterium exchange was used to explore the structure of the stable folding intermediates for the of indole-3-glycerol phosphate synthase from Sulfolobus solfataricus (sIGPS). Previous studies of the urea denaturation of sIGPS revealed the presence of an intermediate that is highly populated at approximately 4.5 M urea and contains approximately 50% of the secondary structure of the native (N) state. Kinetic studies showed that this apparent equilibrium intermediate is actually comprised of two thermodynamically distinct species, I(a) and I(b). To probe the location of the secondary structure in this pair of stable on-pathway intermediates, the equilibrium unfolding process of sIGPS was monitored by hydrogen-deuterium exchange mass spectrometry. The intact protein and pepsin-digested fragments were studied at various concentrations of urea by electrospray and matrix-assisted laser desorption ionization time-of-flight mass spectrometry, respectively. Intact sIGPS strongly protects at least 54 amide protons from hydrogen-deuterium exchange in the intermediate states, demonstrating the presence of stable folded cores. When the protection patterns and the exchange mechanisms for the peptides are considered with the proposed folding mechanism, the results can be interpreted to define the structural boundaries of I(a) and I(b). Comparison of these results with previous hydrogen-deuterium exchange studies on another TIM barrel protein of low sequence identify, alpha-tryptophan synthase (alphaTS), indicates that the thermodynamic states corresponding to the folding intermediates are better conserved than their structures. Although the TIM barrel motif appears to define the basic features of the folding free energy surface, the structures of the partially folded states that appear during the folding reaction depend on the amino acid sequence. Markedly, the good

  4. ID Barrel installed in cryostat

    CERN Document Server

    Apsimon, R.; Romaniouk, A.

    Wednesday 23rd August was a memorable day for the Inner Detector community as they witnessed the transport and installation of the central part of the inner detector (ID-barrel) into the ATLAS detector. Many members of the collaboration gathered to witness this moment at Point 1. After years of design, construction and commissioning, the outer two detectors (TRT and SCT) of the ID barrel were moved from the SR1 cleanroom to the ATLAS cavern. The barrel was moved across the car park from building 2175 to SX1. Although only a journey of about 100 metres, this required weeks of planning and some degree of luck as far as the weather was concerned. Accelerometers were fitted to the barrel to provide real-time monitoring and no values greater than 0.1 g were recorded, fully satisfying the transport specification for this extremely precise and fragile detector. Muriel, despite her fear of heights, bravely volunteered to keep a close eye on the detector. Swapping cranes to cross the entire parking lot, while Mur...

  5. Prototype test for the PANDA barrel DIRC

    Energy Technology Data Exchange (ETDEWEB)

    Dzhygadlo, Roman; Gerhardt, Andreas; Kalicy, Grzegorz; Krebs, Marvin; Lehmann, Dorothe; Schwarz, Carsten; Schwiening, Jochen; Belias, Anastasios; Traxler, Michael [GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt (Germany); Peters, Klaus [GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt (Germany); Goethe-Universitaet Frankfurt (Germany); Collaboration: PANDA-Collaboration

    2016-07-01

    The Barrel DIRC (Detector of Internally Reflected Cherenkov light) is designed to provide particle identification (PID) for the PANDA experiment at the new Facility for Antiproton and Ion Research in Europe (FAIR) at GSI, Darmstadt. It is based on the successful BABAR DIRC detector with several key improvements, such as focusing optics, fast timing, and a compact expansion volume. A large prototype was constructed and tested in a hadronic particle beam at CERN during the summer of 2015 to test the PID performance of different design options. The prototype included a fused silica radiator (either a narrow bar or a wide plate), an optional focusing lens, and a prism-shaped fused silica expansion volume. An array of microchannel-plate photomultiplier tubes measured the location and arrival time of the Cherenkov photons on 960 pixels. Data were collected for two radiator geometries and several types of focusing lenses at different beam momenta and polar angles. Results of the analysis as well as a comparison to the Geant4 simulation are presented.

  6. Crystal Structures of Two Bacterial 3-Hydroxy-3-methylglutaryl-CoA Lyases Suggest a Common Catalytic Mechanism among a Family of TIM Barrel Metalloenzymes Cleaving Carbon-Carbon Bonds

    Energy Technology Data Exchange (ETDEWEB)

    Forouhar,F.; Hussain, M.; Farid, R.; Benach, J.; Abashidze, M.; Edstrom, W.; Vorobiev, S.; Montelione, G.; Hunt, J.; et al.

    2006-01-01

    The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) lyase catalyzes the terminal steps in ketone body generation and leucine degradation. Mutations in this enzyme cause a human autosomal recessive disorder called primary metabolic aciduria, which typically kills victims because of an inability to tolerate hypoglycemia. Here we present crystal structures of the HMG-CoA lyases from Bacillus subtilis and Brucella melitensis at 2.7 and 2.3 {angstrom} resolution, respectively. These enzymes share greater than 45% sequence identity with the human orthologue. Although the enzyme has the anticipated triose-phosphate isomerase (TIM) barrel fold, the catalytic center contains a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel, contrary to the predictions of homology models. Surprisingly, the residues forming this cation-binding site and most of their interaction partners are shared with three other TIM barrel enzymes that catalyze diverse carbon-carbon bond cleavage reactions believed to proceed through enolate intermediates (4-hydroxy-2-ketovalerate aldolase, 2-isopropylmalate synthase, and transcarboxylase 5S). We propose the name 'DRE-TIM metallolyases' for this newly identified enzyme family likely to employ a common catalytic reaction mechanism involving an invariant Asp-Arg-Glu (DRE) triplet. The Asp ligates the divalent cation, while the Arg probably stabilizes charge accumulation in the enolate intermediate, and the Glu maintains the precise structural alignment of the Asp and Arg. We propose a detailed model for the catalytic reaction mechanism of HMG-CoA lyase based on the examination of previously reported product complexes of other DRE-TIM metallolyases and induced fit substrate docking studies conducted using the crystal structure of human HMG-CoA lyase (reported in the accompanying paper by Fu, et al. (2006) J. Biol. Chem. 281, 7526-7532). Our model is consistent with extensive mutagenesis

  7. Heterologous expression and solution structure of defensin from lentil Lens culinaris

    International Nuclear Information System (INIS)

    Shenkarev, Zakhar O.; Gizatullina, Albina K.; Finkina, Ekaterina I.; Alekseeva, Ekaterina A.; Balandin, Sergey V.; Mineev, Konstantin S.; Arseniev, Alexander S.; Ovchinnikova, Tatiana V.

    2014-01-01

    Highlights: • Lentil defensin Lc-def and its 15 N-labeled analog were overexpressed in E. coli. • Lc-def is active against fungi, but does not inhibit growth of G+ and G− bacteria. • Lc-def spatial structure involves triple-stranded β-sheet and α-helix (CSαβ motif). • Lc-def is able to bind to anionic lipid vesicles under low-salt conditions. • NMR data revealed significant μs–ms mobility in the loops 1 and 3 of Lc-def. - Abstract: A new defensin Lc-def, isolated from germinated seeds of the lentil Lens culinaris, has molecular mass 5440.4 Da and consists of 47 amino acid residues. Lc-def and its 15 N-labeled analog were overexpressed in Escherichia coli. Antimicrobial activity of the recombinant protein was examined, and its spatial structure, dynamics, and interaction with lipid vesicles were studied by NMR spectroscopy. It was shown that Lc-def is active against fungi, but does not inhibit the growth of Gram-positive and Gram-negative bacteria. The peptide is monomeric in aqueous solution and contains one α-helix and triple-stranded β-sheet, which form cysteine-stabilized αβ motif (CSαβ) previously found in other plant defensins. The sterically neighboring loop1 and loop3 protrude from the defensin core and demonstrate significant mobility on the μs–ms timescale. Lc-def does not bind to the zwitterionic lipid (POPC) vesicles but interacts with the partially anionic (POPC/DOPG, 7:3) membranes under low-salt conditions. The Lc-def antifungal activity might be mediated through electrostatic interaction with anionic lipid components of fungal membranes

  8. First two barrel ECAL supermodules inserted in CMS HCAL

    CERN Multimedia

    K.Bell

    2006-01-01

    The first two barrel "supermodules" for the CMS Electromagnetic Calorimeter (ECAL) have been inserted into the barrel hadron calorimeter (HCAL) in the experimental hall (called SX5) in Cessy in preparation for the forthcoming magnet test and cosmic challenge (MTCC). Each of the two supermodules contains 1700 lead tungstate crystals in glass-fibre alveolar support structures, with associated avalanche photodiodes (APDs, for scintillation light detection), electronics and cooling system. The barrel ECAL will consist of 36 supermodules, many of which have already been produced (see CERN Bulletin 17-18, 2006). Team from CMS ECAL, CMS Integration and CEA-DAPNIA were involved in the insertion, with the production/integration of the supermodules themselves involving many technicians, engineers and physicists from many institutes. From left to right: Olivier Teller, Maf Alidra and Lucien Veillet.

  9. Increasing the load bearing capacity of barrel vaults

    NARCIS (Netherlands)

    Kamerling, M.W.

    2011-01-01

    Just after World War II many barrel vaults and domes were built with a structural system, known as Fusée Ceramique. This paper analyses the load bearing capacity of these vaults. Schemes, theories, idealizations and assumptions are analysed, validated and discussed. Methods to increase the load

  10. DELPHI Barrel Muon Chamber Module

    CERN Multimedia

    1989-01-01

    The module was used as part of the muon identification system on the barrel of the DELPHI detector at LEP, and was in active use from 1989 to 2000. The module consists of 7 individual muons chambers arranged in 2 layers. Chambers in the upper layer are staggered by half a chamber width with respect to the lower layer. Each individual chamber is a drift chamber consisting of an anode wire, 47 microns in diameter, and a wrapped copper delay line. Each chamber provided 3 signal for each muon passing through the chamber, from which a 3D space-point could be reconstructed.

  11. The OPAL muon barrel detector

    International Nuclear Information System (INIS)

    Akers, R.J.; Allison, J.; Ashton, P.; Bahan, G.A.; Baines, J.T.M.; Banks, J.N.; Barlow, R.J.; Barnett, S.; Beeston, C.; Chrin, J.T.M.; Clowes, S.G.; Davies, O.W.; Duerdoth, I.P.; Hinde, P.S.; Hughes-Jones, R.E.; Lafferty, G.D.; Loebinger, F.K.; Macbeth, A.A.; McGowan, R.F.; Moss, M.W.; Murphy, P.G.; Nijjhar, B.; O'Dowd, A.J.P.; Pawley, S.J.; Phillips, P.D.; Richards, G.E.; Skillman, A.; Stephens, K.; Tresillian, N.J.; Wood, N.C.; Wyatt, T.R.

    1995-01-01

    The barrel part of the OPAL muon detector consists of 110 drift chambers forming four layers outside the hadron absorber. Each chamber covers an area of 1.2 m by up to 10.4 m and has two cells with wires parallel to the beam and a drift distance of 297 mm. A detailed description of the design, construction, operation and performance of the sub-detector is given. The system has been operating successfully since the start of LEP in 1989. ((orig.))

  12. Crystal structure of YwpF from Staphylococcus aureus reveals its architecture comprised of a β-barrel core domain resembling type VI secretion system proteins and a two-helix pair.

    Science.gov (United States)

    Lee, Sang Jae; Lee, Kyu-Yeon; Lee, Ki-Young; Kim, Dong-Gyun; Kim, Soon-Jong; Lee, Bong-Jin

    2015-04-01

    The ywpF gene (SAV2097) of the Staphylococcus aureus strain Mu50 encodes the YwpF protein, which may play a role in antibiotic resistance. Here, we report the first crystal structure of the YwpF superfamily from S. aureus at 2.5-Å resolution. The YwpF structure consists of two regions: an N-terminal core β-barrel domain that shows structural similarity to type VI secretion system (T6SS) proteins (e.g., Hcp1, Hcp3, and EvpC) and a C-terminal two-helix pair. Although the monomer structure of S. aureus YwpF resembles those of T6SS proteins, the dimer/tetramer model of S. aureus YwpF is distinct from the functionally important hexameric ring of T6SS proteins. We therefore suggest that the S. aureus YwpF may have a different function compared to T6SS proteins. © 2015 Wiley Periodicals, Inc.

  13. TRT and SCT barrels merge

    CERN Multimedia

    Wells, P S

    2006-01-01

    The SCT barrel was inserted in the TRT on 17 February, just missing Valentine's day. This was a change of emphasis for the two detectors. In the preceeding months there had been a lot of focus on testing their performance. The TRT had been observing cosmic rays through several sectors of the barrel, and all the modules on each of the four layers of the SCT had been characterised prior to integration. In parallel, the engineering teams, lead by Marco Olcese, Andrea Catinaccio, Eric Perrin, Neil Dixon, Iourii Gusakov, Gerard Barbier and Takashi Kohriki, had been preparing for this critical operation. Figure 1: Neil Dixon and Marco Olcese verifying the final alignment The two detectors had to be painstakingly aligned to be concentric to within a millimetre. The SCT was held on a temporary cantilever stand, and the TRT in the ID trolley had to inch over it. Finally the weight of the SCT was transferred to the rails on the inside of the TRT itself. The SCT services actually protruded a little outside the oute...

  14. Viscous froth lens

    Science.gov (United States)

    Green, T. E.; Bramley, A.; Lue, L.; Grassia, P.

    2006-11-01

    Microscale models of foam structure traditionally incorporate a balance between bubble pressures and surface tension forces associated with curvature of bubble films. In particular, models for flowing foam microrheology have assumed this balance is maintained under the action of some externally imposed motion. Recently, however, a dynamic model for foam structure has been proposed, the viscous froth model, which balances the net effect of bubble pressures and surface tension to viscous dissipation forces: this permits the description of fast-flowing foam. This contribution examines the behavior of the viscous froth model when applied to a paradigm problem with a particularly simple geometry: namely, a two-dimensional bubble “lens.” The lens consists of a channel partly filled by a bubble (known as the “lens bubble”) which contacts one channel wall. An additional film (known as the “spanning film”) connects to this bubble spanning the distance from the opposite channel wall. This simple structure can be set in motion and deformed out of equilibrium by applying a pressure across the spanning film: a rich dynamical behavior results. Solutions for the lens structure steadily propagating along the channel can be computed by the viscous froth model. Perturbation solutions are obtained in the limit of a lens structure with weak applied pressures, while numerical solutions are available for higher pressures. These steadily propagating solutions suggest that small lenses move faster than large ones, while both small and large lens bubbles are quite resistant to deformation, at least for weak applied back pressures. As the applied back pressure grows, the structure with the small lens bubble remains relatively stiff, while that with the large lens bubble becomes much more compliant. However, with even further increases in the applied back pressure, a critical pressure appears to exist for which the steady-state structure loses stability and unsteady

  15. Study of the structure of buffalo's eye lens and scleroretinal rim in Tabriz by ultrasonography

    Directory of Open Access Journals (Sweden)

    GH Assadnassab

    2011-05-01

    Full Text Available In this study, ultrasonographic condition of lens and posterior wall of buffalo's eye in Tabriz area were investigated due to their important role in vision and also measurements were made in anterior-posterior axial B-mode display methods. The ultrasonographic images were similar to the images obtained from other particularly the cow. Total thickness of the lens was 1.133 ± 0.052 cm with the thickness being 1.135 ± 0.052 cm in the right eye and 1.132 ± 0.053 cm in the left eye. Thickness of the posterior wall of the right and left eyes were 1.677 ± 0.042 mm and 1.672 ± 0.041 mm respectively with the total thickness of the posterior wall measuring 1.674 ± 0.040 mm. There was no significant difference between the left and right eyes regarding these parameters.

  16. The 2003 Tracker Inner Barrel Beam Test

    CERN Document Server

    Boccali, Tommaso; Borrello, Laura; Carrone, Enzo; Chiorboli, Massimiliano; Ciulli, Vitaliano; Civinini, Carlo; D'Alfonso, Mariarosaria; De Filippis, Nicola; Dell'Orso, Roberto; Drouhin, Frédéric; Dutta, Suchandra; Giammanco, Andrea; Giassi, Alessandro; Giordano, Domenico; Kaminski, A; Macchiolo, Anna; Marchettini, Cristiano; Meschini, Marco; Mirabito, Laurent; My, Salvatore; Palla, Fabrizio; Palmonari, Francesco; Paoletti, Simone; Radicci, Valeria; Ranieri, Riccardo; Segneri, Gabriele; Siegrist, Patrice; Silvestris, Lucia; Tricomi, Alessia; Tsirou, Andromachi; Verdini, Piero Giorgio

    2008-01-01

    Before starting the CMS Silicon Strip Tracker (SST) mass production, where the quality control tests can only be done on single components, an extensive collection of activities aiming at validating the tracker system functionality has been performed. In this framework, a final component prototype of the Inner Barrel part (TIB) of the SST has been assembled and tested in the INFN laboratories and then moved to CERN to check its behaviour in a 25~ns LHC-like particle beam. A set of preproduction single-sided silicon microstrip modules was mounted on a mechanical structure very similar to a sector of the third layer of the TIB and read out using a system functionally identical to the final one. In this note the system setup configuration is fully described and the results of the test, concerning both detector performance and system characteristics, are presented and discussed.

  17. Renovating a Fusee Ceramique Barrel Vault

    NARCIS (Netherlands)

    Kamerling, M.W.

    2015-01-01

    This paper describes a proposal to renovate a Fusee Ceramique Barrel Vault with steel diagonals In 1956 two workshops, varying in height and span, were built in Wormerveer, The Netherlands. Both workshops were roofed with a concrete barrel vault with a thickness of 110 mm. The cylindrical vaults

  18. The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism.

    Science.gov (United States)

    Goldman, Aaron David; Beatty, Joshua T; Landweber, Laura F

    2016-01-01

    The triosephosphate isomerase (TIM) barrel protein fold is a structurally repetitive architecture that is present in approximately 10% of all enzymes. It is generally assumed that this ubiquity in modern proteomes reflects an essential historical role in early protein-mediated metabolism. Here, we provide quantitative and comparative analyses to support several hypotheses about the early importance of the TIM barrel architecture. An information theoretical analysis of protein structures supports the hypothesis that the TIM barrel architecture could arise more easily by duplication and recombination compared to other mixed α/β structures. We show that TIM barrel enzymes corresponding to the most taxonomically broad superfamilies also have the broadest range of functions, often aided by metal and nucleotide-derived cofactors that are thought to reflect an earlier stage of metabolic evolution. By comparison to other putatively ancient protein architectures, we find that the functional diversity of TIM barrel proteins cannot be explained simply by their antiquity. Instead, the breadth of TIM barrel functions can be explained, in part, by the incorporation of a broad range of cofactors, a trend that does not appear to be shared by proteins in general. These results support the hypothesis that the simple and functionally general TIM barrel architecture may have arisen early in the evolution of protein biosynthesis and provided an ideal scaffold to facilitate the metabolic transition from ribozymes, peptides, and geochemical catalysts to modern protein enzymes.

  19. Objective lens

    Science.gov (United States)

    Olczak, Eugene G. (Inventor)

    2011-01-01

    An objective lens and a method for using same. The objective lens has a first end, a second end, and a plurality of optical elements. The optical elements are positioned between the first end and the second end and are at least substantially symmetric about a plane centered between the first end and the second end.

  20. Azimuthally anisotropic hydride lens structures in Zircaloy 4 nuclear fuel cladding: High-resolution neutron radiography imaging and BISON finite element analysis

    Science.gov (United States)

    Lin, Jun-Li; Zhong, Weicheng; Bilheux, Hassina Z.; Heuser, Brent J.

    2017-12-01

    High-resolution neutron radiography has been used to image bulk circumferential hydride lens particles in unirradiated Zircaloy 4 tubing cross section specimens. Zircaloy 4 is a common light water nuclear reactor (LWR) fuel cladding; hydrogen pickup, hydride formation, and the concomitant effect on the mechanical response are important for LWR applications. Ring cross section specimens with three hydrogen concentrations (460, 950, and 2830 parts per million by weight) and an as-received reference specimen were imaged. Azimuthally anisotropic hydride lens particles were observed at 950 and 2830 wppm. The BISON finite element analysis nuclear fuel performance code was used to model the system elastic response induced by hydride volumetric dilatation. The compressive hoop stress within the lens structure becomes azimuthally anisotropic at high hydrogen concentrations or high hydride phase fraction. This compressive stress anisotropy matches the observed lens anisotropy, implicating the effect of stress on hydride formation as the cause of the observed lens azimuthal asymmetry. The cause and effect relation between compressive stress and hydride lens anisotropy represents an indirect validation of a key BISON output, the evolved hoop stress associated with hydride formation.

  1. Celebrating the Barrel Toroid commissioning

    CERN Multimedia

    Peter Jenni

    ATLAS invited Funding Agency representatives and Laboratory Heads directly related to the funding and construction of the Barrel Toroid for a small ceremony on 13th December 2006 at Point 1, in order to mark the successful first full excitation of the BT (see last eNews). On that date, which was during the December CERN Council week, several of the Funding Agency Heads or their representatives could be present, representing CEA France, INFN Italy, BMBF Germany, Spain, Sweden, Switzerland, Russia, JINR Dubna and CERN. Speeches were delivered by the ATLAS spokesperson Peter Jenni thanking the Funding Partners in the name of the Collaboration, by Magnet Project Leader Herman ten Kate tracing the BT construction history, and by the CERN Director-General Robert Aymar congratulating all those who have contributed to the successful project. Herman ten Kate addressing the delegates. The text of the introductory address by Peter Jenni is reproduced here. "It is a great pleasure for me to welcome you all here...

  2. Liquid Argon Barrel Cryostat Arrived

    CERN Multimedia

    Pailler, P

    Last week the first of three cryostats for the ATLAS liquid argon calorimeter arrived at CERN. It had travelled for 46 days over several thousand kilometers from Japan to CERN. During three years it has been fabricated by Kawasaki Heavy Industries Ltd. at Harima, close to Kobe, under contract from Brookhaven National Laboratory (BNL) of the U.S.. This cryostat consists of two concentric cylinders made of aluminium: the outer vacuum vessel with a diameter of 5.5 m and a length of 7 m, and the inner cold vessel which will contain the electromagnetic barrel calorimeter immersed in liquid argon. The total weight will be 270 tons including the detectors and the liquid argon. The cryostat is now located in building 180 where it will be equipped with 64 feed-throughs which serve for the passage of 122,880 electrical lines which will carry the signals of the calorimeter. After integration of the calorimeter, the solenoidal magnet of ATLAS will be integrated in the vacuum vessel. A final cold test of the cryostat inc...

  3. Design and construction of the ZEUS barrel calorimeter

    International Nuclear Information System (INIS)

    Repond, J.

    1990-01-01

    The mechanical design and construction techniques of the barrel calorimeter for the ZEUS detector are presented. The calorimeter uses alternate layers of depleted uranium and scintillator with one radiation length sampling. The unit cell has e/h = 1 which yields an optimal energy resolution for hadronic jets. We discuss the placing of the structural components and cracks between modules. Details of the construction and assembly effort needed to realize the total calorimeter are reported. 4 figs., 1 tab

  4. Track reconstruction in BES barrel shower counter

    International Nuclear Information System (INIS)

    Zhao Haiwen; Wang Taijie; Mao Zepu; Li Jin; Li Weiguo; Yan Wuguang; Chen Guangpei; Liu Jing; Li Peiqin; Rong Gang; Yuan Ye; Liu Hongtao

    1999-01-01

    The track reconstruction of BES barrel shower counter was presented and the shower finding, pattern recognition technique were described. The reconstruction results from experimental data were presented and discussed

  5. Understanding and Predicting Gun Barrel Erosion

    National Research Council Canada - National Science Library

    Johnston, Ian A

    2005-01-01

    The Australian Defence Force will soon have to contend with gun barrel erosion issues arising from the use of new low-vulnerability gun propellants, the acquisition of new ammunition and gun systems...

  6. Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor.

    Science.gov (United States)

    Hannon, Clare; Cruz-Migoni, Abimael; Platonova, Olga; Owen, Robin L; Nettleship, Joanne E; Miller, Ami; Carr, Stephen B; Harris, Gemma; Rabbitts, Terence H; Phillips, Simon E V

    2018-03-01

    Lens epithelium-derived growth factor (LEDGF)/p75 is the dominant binding partner of HIV-1 integrase in human cells. The crystal structure of the HIV integrase-binding domain (IBD) of LEDGF has been determined in the absence of ligand. IBD was overexpressed in Escherichia coli, purified and crystallized by sitting-drop vapour diffusion. X-ray diffraction data were collected at Diamond Light Source to a resolution of 2.05 Å. The crystals belonged to space group P2 1 , with eight polypeptide chains in the asymmetric unit arranged as an unusual octamer composed of four domain-swapped IBD dimers. IBD exists as a mixture of monomers and dimers in concentrated solutions, but the dimers are unlikely to be biologically relevant.

  7. Development of new maskless manufacturing method for anti-reflection structure and application to large-area lens with curved surface

    Science.gov (United States)

    Yamamoto, Kazuya; Takaoka, Toshimitsu; Fukui, Hidetoshi; Haruta, Yasuyuki; Yamashita, Tomoya; Kitagawa, Seiichiro

    2016-03-01

    In general, thin-film coating process is widely applied on optical lens surface as anti-reflection function. In normal production process, at first lens is manufactured by molding, then anti-reflection is added by thin-film coating. In recent years, instead of thin-film coating, sub-wavelength structures adding on surface of molding die are widely studied and development to keep anti-reflection performance. As merits, applying sub-wavelength structure, coating process becomes unnecessary and it is possible to reduce man-hour costs. In addition to cost merit, these are some technical advantages on this study. Adhesion of coating depends on material of plastic, and it is impossible to apply anti-reflection function on arbitrary surface. Sub-wavelength structure can solve both problems. Manufacturing method of anti-reflection structure can be divided into two types mainly. One method is with the resist patterning, and the other is mask-less method that does not require patterning. What we have developed is new mask-less method which is no need for resist patterning and possible to impart an anti-reflection structure to large area and curved lens surface, and can be expected to apply to various market segments. We report developed technique and characteristics of production lens.

  8. Study and analysis on the flow induced vibration of the core barrel of PWR

    International Nuclear Information System (INIS)

    Yao Weida; Shi Guolin; Jiang Nanyan; Peng YongYong; Zhang Huijun; Wang Yufen; Xie Yongcheng; Guo Chunhua; Shen Qinping

    1989-01-01

    The deduction of the resemblance criterion and the design of the test model by applying flow-solid coupling theory are described. The model analysis of a core barrel both in the air and stationary water were performed in a 1:10 model, thus obtaining the dynamic characteristic. In a 1:5 reactor model with a hydraulic closed loop, the inner structure and support were modeled for performing hydraulic closed loop, the inner structure and support were modeled for performing hydraulic vibration test of the core barrel. The flow induced pulse pressure of the core barrel and corresponding response were obtained by using miniature pressure capsule, strain gauge and accelerometer. Power spectrum, correlation functions, transfer function and amplitudes under different flow velocities were calculated. The hydraulic vibration test shows that the core barrel will be in safety during its 30-year life time

  9. Work on the ATLAS semiconductor tracker barrel

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    Precision work is performed on the semiconductor tracker barrel of the ATLAS experiment. All work on these delicate components must be performed in a clean room so that impurities in the air, such as dust, do not contaminate the detector. The semiconductor tracker will be mounted in the barrel close to the heart of the ATLAS experiment to detect the path of particles produced in proton-proton collisions.

  10. First SCT Barrel arrives at CERN

    CERN Multimedia

    Apsimon, R

    Mid-January saw the arrival at CERN of Barrel #3, the first of four SCT barrels. The barrels are formed as low-mass cylinders of carbon fibre skins on a honeycomb carbon core. They are manufactured in industry and then have all the final precision supports added and the final geometric metrology carried out at Geneva University. Barrel #3, complete with its 384 silicon detector modules, arrived by road from Oxford University in England where the modules were mounted using a purpose-built robot. The modules had been selected from the output of all four barrel module building clusters (in Japan, Scandinavia, USA and the UK). Since Barrel #3 will be exposed to high radiation levels within the tracker volume, these modules, representing over half a million readout channels, have been extensively tested at their operational temperature of around -25 degrees Celcius and at voltages of up to 500V. The dangers of shipping such a fragile component of ATLAS were apparent to all and considerable attention was focused...

  11. First half-barrel of the CMS hadron calorimeter successfully asembled

    CERN Multimedia

    2001-01-01

    The first half barrel of the CMS hadron calorimeter has been assembled in the CMS construction hall in Cessy (neighbouring France), called SX5, in October 2001. The picture sequence shows the insertion of the last (the keystone) wedge. It is lifted up to the top of the structure and carefully inserted into the half barrel. Photos 6 and 7 show the HB- in SX5.

  12. Structure of a Highly Active Cephalopod S-crystallin Mutant: New Molecular Evidence for Evolution from an Active Enzyme into Lens-Refractive Protein.

    Science.gov (United States)

    Tan, Wei-Hung; Cheng, Shu-Chun; Liu, Yu-Tung; Wu, Cheng-Guo; Lin, Min-Han; Chen, Chiao-Che; Lin, Chao-Hsiung; Chou, Chi-Yuan

    2016-08-08

    Crystallins are found widely in animal lenses and have important functions due to their refractive properties. In the coleoid cephalopods, a lens with a graded refractive index provides good vision and is required for survival. Cephalopod S-crystallin is thought to have evolved from glutathione S-transferase (GST) with various homologs differentially expressed in the lens. However, there is no direct structural information that helps to delineate the mechanisms by which S-crystallin could have evolved. Here we report the structural and biochemical characterization of novel S-crystallin-glutathione complex. The 2.35-Å crystal structure of a S-crystallin mutant from Octopus vulgaris reveals an active-site architecture that is different from that of GST. S-crystallin has a preference for glutathione binding, although almost lost its GST enzymatic activity. We've also identified four historical mutations that are able to produce a "GST-like" S-crystallin that has regained activity. This protein recapitulates the evolution of S-crystallin from GST. Protein stability studies suggest that S-crystallin is stabilized by glutathione binding to prevent its aggregation; this contrasts with GST-σ, which do not possess this protection. We suggest that a tradeoff between enzyme activity and the stability of the lens protein might have been one of the major driving force behind lens evolution.

  13. Chiropractic professionalization and accreditation: an exploration of the history of conflict between worldviews through the lens of developmental structuralism.

    Science.gov (United States)

    Senzon, Simon A

    2014-12-01

    The purpose of this commentary is to describe the conflicts in the history of chiropractic's professionalization and conflict through the path of increasing educational standards and accreditation using the lens of developmental structuralism. Within the story of chiropractic's professionalization and accreditation lie the battles between competing worldviews. Gibbons proposed 4 periods of chiropractic's educational history; this article proposes a fifth period along with a new methodological approach to explore the complexity of chiropractic's history. The methodology draws upon constructive developmental psychology and proposes 5 levels of thinking common to the individuals from chiropractic's history. By using a psychological framework to analyze historical events, it appears that the battle within chiropractic education continues at present. Several important issues are explored: the Council on Chiropractic Education's origins in the medical paradigm and rational thinking, the pre-rational, rational, and post-rational critics of the Council on Chiropractic Education, the schools of thought that were reified or emerged from the history, as well as the more recent legal, economic, and social pressures, which helped to shape chiropractic's accreditation and professionalization. A transrational approach, one that includes the partial truths of all perspectives, is a first step to allow for a richer understanding of how the interior worldviews, individual actions, and the exterior forces (legal, economic, political, and educational) brought forth the chiropractic clashes together. Viewing the conflicts within chiropractic from this approach may foster new educational structures to evolve.

  14. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory...

  15. Assembly of β-barrel proteins in the mitochondrial outer membrane.

    Science.gov (United States)

    Höhr, Alexandra I C; Straub, Sebastian P; Warscheid, Bettina; Becker, Thomas; Wiedemann, Nils

    2015-01-01

    Mitochondria evolved through endosymbiosis of a Gram-negative progenitor with a host cell to generate eukaryotes. Therefore, the outer membrane of mitochondria and Gram-negative bacteria contain pore proteins with β-barrel topology. After synthesis in the cytosol, β-barrel precursor proteins are first transported into the mitochondrial intermembrane space. Folding and membrane integration of β-barrel proteins depend on the mitochondrial sorting and assembly machinery (SAM) located in the outer membrane, which is related to the β-barrel assembly machinery (BAM) in bacteria. The SAM complex recognizes β-barrel proteins by a β-signal in the C-terminal β-strand that is required to initiate β-barrel protein insertion into the outer membrane. In addition, the SAM complex is crucial to form membrane contacts with the inner mitochondrial membrane by interacting with the mitochondrial contact site and cristae organizing system (MICOS) and shares a subunit with the endoplasmic reticulum-mitochondria encounter structure (ERMES) that links the outer mitochondrial membrane to the endoplasmic reticulum (ER). Copyright © 2014 Elsevier B.V. All rights reserved.

  16. The CMS Barrel Muon trigger upgrade

    International Nuclear Information System (INIS)

    Triossi, A.; Sphicas, P.; Bellato, M.; Montecassiano, F.; Ventura, S.; Ruiz, J.M. Cela; Bedoya, C. Fernandez; Tobar, A. Navarro; Fernandez, I. Redondo; Ferrero, D. Redondo; Sastre, J.; Ero, J.; Wulz, C.; Flouris, G.; Foudas, C.; Loukas, N.; Mallios, S.; Paradas, E.; Guiducci, L.; Masetti, G.

    2017-01-01

    The increase of luminosity expected by LHC during Phase1 will impose tighter constraints for rate reduction in order to maintain high efficiency in the CMS Level1 trigger system. The TwinMux system is the early layer of the muon barrel region that concentrates the information from different subdetectors: Drift Tubes, Resistive Plate Chambers and Outer Hadron Calorimeter. It arranges the slow optical trigger links from the detector chambers into faster links (10 Gbps) that are sent in multiple copies to the track finders. Results from collision runs, that confirm the satisfactory operation of the trigger system up to the output of the barrel track finder, will be shown.

  17. In-situ alloyed LENS additively manufactured TiAl-Nb structure

    CSIR Research Space (South Africa)

    Tlotleng, Monnamme

    2017-11-01

    Full Text Available Titanium aluminides (TiAl) are interesting intermetallic materials to study due to their enhanced high temperature and light weight properties. They are necessary as structural materials, but brittle to form with conventional methods. Hence big...

  18. Primary Dystonia: Conceptualizing the Disorder through a Structural Brain Imaging Lens

    Directory of Open Access Journals (Sweden)

    Kristina Simonyan

    2013-06-01

    Full Text Available Background: Dystonia is a hyperkinetic movement disorder of involuntary, twisting repetitive movements. The anatomical structures and pathways implicated in its pathogenesis as well as their relationship to the neurophysiological paradigm of abnormal surround inhibition, maladaptive plasticity and impaired sensorimotor integration remain not well delineated. Objective: We review the use of high-resolution structural brain imaging using voxel-based morphometry (VBM and diffusion tensor imaging (DTI techniques for evaluation of brain changes in primary torsion dystonia and their relationships to the pathophysiology of this disorder. Methods: A search in PubMed was conducted to identify the relevant literature. Discussion: Structural imaging has enhanced our understanding of the pathophysiological mechanisms of dystonia. In particular, VBM and DTI data have revealed microstructural disturbances in the basal ganglia, sensorimotor cortices and cerebellum along with aberrations in the cortico-striato-pallido-thalamic and cerebello-thalamo-cortical pathways.  When combined with functional brain imaging and neurophysiological modalities, a structure-function relationship can be established in the dystonia brain network at the sensorimotor, plasticity, cortical disinhibition and cerebellar outflow connectivity levels. Structural imaging highlighted new anatomical substrates and, with a combined structural-functional approach, has offered new opportunities for investigation of the neurodevelopmental, environmental and/or genetic interplay in the brain networks of dystonia patients. 

  19. Learning Practice and Technology: Extending the Structurational Practice Lens to Educational Technology Research

    Science.gov (United States)

    Halperin, Ruth

    2017-01-01

    Scholars in the field of educational technology have been calling for robust use of social theory within learning technology research. In view of that, interest has been noted in applying Giddens' structuration theory to the understanding of human interaction with technology in learning settings. However, only few such attempts have been published…

  20. Microstructure and mechanical properties of LENS fabricated TiAl structures

    CSIR Research Space (South Africa)

    Tlotleng, M

    2016-11-01

    Full Text Available It is difficult to produce titanium aluminides (TiAl) components because these materials lack ductility and when used as high temperature structures they fail prematurely due to the inability to self-oxidise. In this study, a 20 by 20 mm cube part...

  1. Laser surface micro-/nano-structuring by a simple transportable micro-sphere lens array

    NARCIS (Netherlands)

    Sedao, X.; Derrien, T.J.Y.; Romer, G.W.R.B.E.; Pathiraj, B.; Huis in 't Veld, A.J.

    2012-01-01

    A micro-sphere array optic was employed for laser surface micro-structuring. This array optic consists of a hexagonally close-packed monolayer of silica micro-spheres. It was organized through a self-assembly process and held together on a glass support, without using any adhesives. The array

  2. ATLAS barrel hadron calorimeter module design

    International Nuclear Information System (INIS)

    Budagov, Yu.A.; Chirikov-Zorin, I.

    1995-01-01

    Here we presented the detailed description of the 6-meter module modification design version. The basic idea is to use - for the module assembly - 19 glued 30-cm thick sub modules. The sub module design, 6 m module assembling technology, the auxiliary assembling device are presented; also described: different options of the module's slinging when barrel assembling; modules packing and transporting. 22 figs

  3. Celebration for the ATLAS Barrel Toroid magnet

    CERN Multimedia

    2007-01-01

    Representatives from Funding Agencies and Barrel Toroid Magnet Laboratories during the ceremony. From left to right: Jean Zinn-Justin (Head of DAPNIA/CEA/Saclay), CERN Director-General Robert Aymar, and Roberto Petronzio (President INFN).Allan Clark (DPNC University Geneva) and Enrique Fernandez (IFAE Barcelona) were among the guests visiting the ATLAS cavern. The barrel toroid is visible in the background. A celebration took place at Point 1 on 13 December to toast the recent powering-up of the ATLAS barrel toroid magnet to full field (Bulletin No. 47-48/06). About 70 guests were invited to attend, mainly composed of representatives from funding partners and key members of the laboratory management teams of the barrel toroid magnet, representing CEA France, INFN Italy, BMBF Germany, Spain, Sweden, Switzerland, Russia, JINR Dubna and CERN. An introductory speech by ATLAS spokesperson Peter Jenni the scene for evening. This was followed by the ATLAS magnet system project leader Herman Ten Kate's account of the...

  4. Last Few Metres for the Barrel Calorimeter

    CERN Multimedia

    Nyman, T.

    On Friday 4th November, the ATLAS Barrel Calorimeter was moved from its assembly point at the side of the ATLAS cavern to the centre of the toroidal magnet system. The detector was finally aligned, to the precision of within a millimetre, on Wednesday 9th November. The ATLAS installation team, led by Tommi Nyman, after having positioned the Barrel Calorimeter in its final location in the ATLAS experimental cavern UX15. The Barrel Calorimeter which will absorb and measure the energy of photons, electrons and hadrons at the core of the ATLAS detector is 8.6 meters in diameter, 6.8 meters long, and weighs over 1600 Tonnes. It consists of two concentric cylindrical detector elements. The innermost comprises aluminium pressure vessels containing the liquid argon electromagnetic calorimeter and the solenoid magnet. The outermost is an assembly of 64 hadron tile calorimeter sectors. Assembled 18 meters away from its final position, the Barrel Calorimeter was relocated with the help of a railway, which allows ...

  5. ATLAS Barrel Toroid magnet reached nominal field

    CERN Multimedia

    2006-01-01

     On 9 November the barrel toroid magnet reached its nominal field of 4 teslas, with an electrical current of 21 000 amperes (21 kA) passing through the eight superconducting coils as shown on this graph

  6. Significant genetic differentiation among meroplanktonic barrel ...

    African Journals Online (AJOL)

    We examined genetic variation and divergence within the meroplanktonic barrel jellyfish Rhizostoma pulmo in the Mediterranean Sea; specific sampling areas were the northern Adriatic, western Mediterranean and Tunisian coast. A total of 19 sampling sites and 68 sequences of the mtDNA cytochrome c oxidase subunit I ...

  7. ATLAS semiconductor tracker installed into its barrel

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    The ATLAS silicon tracker is installed in the silicon tracker barrel. Absolute precision was required in this operation to ensure that the tracker was inserted without damage through minimal clearance. The installation was performed in a clean room on the CERN site so that no impurities in the air would contaminate the tracker's systems.

  8. Shell model in-water frequencies of the core barrel

    International Nuclear Information System (INIS)

    Takeuchi, K.; De Santo, D.F.

    1980-01-01

    Natural frequencies of a 1/24th-scale core barrel/vessel model in air and in water are measured by determining frequency responses to applied forces. The measured data are analyzed by the use of the one-dimensional fluid-structure computer code, MULTIFLEX, developed to calculate the hydraulic force. The fluid-structure interaction in the downcomer annulus is computed with a one-dimensional network model formed to be equivalent to two-dimensional fluid-structure interaction. The structural model incorporated in MULTIFLEX is substantially simpler than that necessary for structural analyses. Proposed for computation of structural dynamics is the projector method than can deal with the beam mode by modal analysis and the other shell modes by a direct integration method. Computed in-air and in-water frequencies agree fairly well with the experimental data, verifying the above MULTIFLEX technique

  9. Beta-Barrel Detection for Medium Resolution Cryo-Electron Microscopy Density Maps Using Genetic Algorithms and Ray Tracing.

    Science.gov (United States)

    Ng, Albert; Si, Dong

    2017-10-16

    Cryo-electron microscopy (cryo-EM) is a technique that produces three-dimensional density maps of large protein complexes. This allows for the study of the structure of these proteins. Identifying the secondary structures within proteins is vital to understanding the overall structure and function of the protein. The [Formula: see text]-barrel is one such secondary structure, commonly found in lipocalins and membrane proteins. In this article, we present a novel approach that utilizes genetic algorithms, kd-trees, and ray tracing to automatically detect and extract [Formula: see text]-barrels from cryo-EM density maps. This approach was tested on simulated and experimental density maps with zero, one, or multiple barrels in the density map. The results suggest that the proposed approach is capable of performing automatic detection of [Formula: see text]-barrels from medium resolution cryo-EM density maps.

  10. Age-related compaction of lens fibers affects the structure and optical properties of rabbit lenses

    Directory of Open Access Journals (Sweden)

    Al-Ghoul Walid M

    2007-12-01

    Full Text Available Abstract Background The goal of this investigation was to correlate particular age-related structural changes (compaction to the amount of scatter in rabbit lenses and to determine if significant fiber compaction occurred in the nuclear and inner cortical regions. Methods New Zealand White rabbits at 16–20 months old (adult; n = 10 and at 3.5–4 years old (aged; n = 10 were utilized for this study. Immediately after euthanising, scatter was assessed in fresh lenses by low power helium-neon laser scan analysis. Scatter data was analyzed both for whole lenses and regionally, to facilitate correlation with morphometric data. After functional analysis, lenses were fixed and processed for scanning electron microcopy (SEM; right eyes and light microscopy (LM; left eyes. Morphometric analysis of SEM images was utilized to evaluate compaction of nuclear fibers. Similarly, measurements from LM images were used to assess compaction of inner cortical fibers. Results Scatter was significantly greater in aged lenses as compared to adult lenses in all regions analyzed, however the difference in the mean was slightly more pronounced in the inner cortical region. The anterior and posterior elliptical angles at 1 mm (inner fetal nucleus were significantly decreased in aged vs. adult lenses (anterior, p = 0.040; posterior, p = 0.036. However, the average elliptical angles at 2.5 mm (outer fetal nucleus were not significantly different in adult and aged lenses since all lenses examined had comparable angles to inner fetal fibers of aged lenses, i.e. they were all compacted. In cortical fibers, measures of average cross-sectional fiber area were significantly different at diameters of both 6 and 7 mm as a function of age (p = 0.011 and p = 0.005, respectively. Accordingly, the estimated fiber volume was significantly decreased in aged as compared to adult lenses at both 6 mm diameter (p = 0.016 and 7 mm diameter (p = 0.010. Conclusion Morphometric data indicates

  11. Cobalamin-independent methionine synthase (MetE: a face-to-face double barrel that evolved by gene duplication.

    Directory of Open Access Journals (Sweden)

    Robert Pejchal

    2005-02-01

    Full Text Available Cobalamin-independent methionine synthase (MetE catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH, both enzymes require zinc for activation and binding of Hcy. Crystallographic analyses of MetE from T. maritima reveal an unusual dual-barrel structure in which the active site lies between the tops of the two (betaalpha(8 barrels. The fold of the N-terminal barrel confirms that it has evolved from the C-terminal polypeptide by gene duplication; comparisons of the barrels provide an intriguing example of homologous domain evolution in which binding sites are obliterated. The C-terminal barrel incorporates the zinc ion that binds and activates Hcy. The zinc-binding site in MetE is distinguished from the (Cys(3Zn site in the related enzymes, MetH and betaine-homocysteine methyltransferase, by its position in the barrel and by the metal ligands, which are histidine, cysteine, glutamate, and cysteine in the resting form of MetE. Hcy associates at the face of the metal opposite glutamate, which moves away from the zinc in the binary E.Hcy complex. The folate substrate is not intimately associated with the N-terminal barrel; instead, elements from both barrels contribute binding determinants in a binary complex in which the folate substrate is incorrectly oriented for methyl transfer. Atypical locations of the Hcy and folate sites in the C-terminal barrel presumably permit direct interaction of the substrates in a ternary complex. Structures of the binary substrate complexes imply that rearrangement of folate, perhaps accompanied by domain rearrangement, must occur before formation of a ternary complex that is competent for methyl transfer.

  12. Cobalamin-Independent Methionine Synthase (MetE): A Face-to-Face Double Barrel that Evolved by Gene Duplication

    Energy Technology Data Exchange (ETDEWEB)

    Pejcha, Robert; Ludwig, Martha L. (Michigan)

    2010-03-08

    Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zinc for activation and binding of Hcy. Crystallographic analyses of MetE from T. maritima reveal an unusual dual-barrel structure in which the active site lies between the tops of the two ({beta}{alpha}){sub 8} barrels. The fold of the N-terminal barrel confirms that it has evolved from the C-terminal polypeptide by gene duplication; comparisons of the barrels provide an intriguing example of homologous domain evolution in which binding sites are obliterated. The C-terminal barrel incorporates the zinc ion that binds and activates Hcy. The zinc-binding site in MetE is distinguished from the (Cys){sub 3}Zn site in the related enzymes, MetH and betaine-homocysteine methyltransferase, by its position in the barrel and by the metal ligands, which are histidine, cysteine, glutamate, and cysteine in the resting form of MetE. Hcy associates at the face of the metal opposite glutamate, which moves away from the zinc in the binary E {center_dot} Hcy complex. The folate substrate is not intimately associated with the N-terminal barrel; instead, elements from both barrels contribute binding determinants in a binary complex in which the folate substrate is incorrectly oriented for methyl transfer. Atypical locations of the Hcy and folate sites in the C-terminal barrel presumably permit direct interaction of the substrates in a ternary complex. Structures of the binary substrate complexes imply that rearrangement of folate, perhaps accompanied by domain rearrangement, must occur before formation of a ternary complex that is competent for methyl transfer.

  13. First half of CMS inner tracker barrel

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    The first half of the CMS inner tracker barrel is seen in this image consisting of three layers of silicon modules which will be placed at the centre of the CMS experiment at the LHC in CERN. Laying close to the interaction point of the 14 TeV proton-proton collisions, the silicon used here must be able to survive high doses of radiation and a 4 T magnetic field without damage.

  14. Differential contribution of tryptophans to the folding and stability of the attachment invasion locus transmembrane β-barrel from Yersinia pestis.

    Science.gov (United States)

    Gupta, Ankit; Zadafiya, Punit; Mahalakshmi, Radhakrishnan

    2014-09-30

    Attachment invasion locus (Ail) protein of Yersinia pestis is a crucial outer membrane protein for host invasion and determines bacterial survival within the host. Despite its importance in pathogenicity, surprisingly little is known on Ail biophysical properties. We investigate the contribution of micelle concentrations and interface tryptophans on the Ail β-barrel refolding and unfolding processes. Our results reveal that barrel folding is surprisingly independent of micelle amounts, but proceeds through an on-pathway intermediate that requires the interface W42 for cooperative barrel refolding. On the contrary, the unfolding event is strongly controlled by absolute micelle concentrations. We find that upon Trp → Phe substitution, protein stabilities follow the order W149F>WT>W42F for the refolding, and W42F>WT>W149F for unfolding. W42 confers cooperativity in barrel folding, and W149 clamps the post-folded barrel structure to its micelle environment. Our analyses reveal, for the first time, that interface tryptophan mutation can indeed render greater β-barrel stability. Furthermore, hysteresis in Ail stems from differential barrel-detergent interaction strengths in a micelle concentration-dependent manner, largely mediated by W149. The kinetically stabilized Ail β-barrel has strategically positioned tryptophans to balance efficient refolding and subsequent β-barrel stability, and may be evolutionarily chosen for optimal functioning of Ail during Yersinia pathogenesis.

  15. Application of advanced thermal management technologies to the ATLAS SCT barrel module baseboards

    International Nuclear Information System (INIS)

    Apsimon, R.J.; Batchelor, L.E.; Beck, G.A.; Canard, P.; Carter, A.A.; Carter, J.R.; Davis, V.R.; Oliveira, R. de; Gibson, M.D.; Hominal, L.; Ilie, D.M.; Ilie, S.D.; Leboube, C.G.; Mistry, J.; Morin, J.; Morris, J.; Nagai, K.; Sexton, I.; Thery, X.; Tyndel, M.

    2006-01-01

    The paper describes the application of advanced thermal management technologies to the design and production of the barrel module baseboard of the SemiConductor Tracker (SCT) of the ATLAS experiment at the Large Hadron Collider (LHC). The barrel modules contain silicon microstrip sensors and readout ASICs for tracking charged particles, and the baseboard forms the central element of the module, providing both its necessary thermal management and its mechanical structure. The baseboard requirements and specifications are given, and design and fabrication details are described. The properties of the 3000 baseboards successfully produced for the SCT are summarised

  16. Comparison between the contribution of ellagitannins of new oak barrels and one-year-used barrels

    Directory of Open Access Journals (Sweden)

    Navarro María

    2016-01-01

    Full Text Available The influence of the botanical origin (French oak: Quercus petraea and American oak: Quercus alba, toasting level and if the barrel were new of previously used during one year have been studied. Results indicate that French oak released significant higher amounts of ellagitannins than American oak. Toasting level also exert a great influence. The higher the toasting level the lower the ellagitannin concentration in wines. Finally, the use during one year of the barrels drastically decreases the ellagitannin concentration in wines. Consequently, it can be concluded that the origin of oak, the toasting level and especially the previous use of the barrels have a very significant influence on the final ellagitannin concentration in wine, and probably on its sensory impact.

  17. Numerical analyses of planer plasmonic focusing lens

    Science.gov (United States)

    Chou, Yen-Yu; Lee, Yeeu-Chang

    2018-03-01

    The use of polystyrene (PS) sphere lithography has been widely applied in the fabrication of micron and nano structures, due to their low cost and ease of fabrication in large scale applications. This study evaluated the feasibility of plasmonic lens base on metal thin films with nanohole structures fabricated by using PS sphere lithography through three-dimensional (3D) finite difference time domain (FDTD) method. We calculated the intensity profile of lens with various wavelength of incident light, lens size, cutting positions, diameters of nanohole, and periods of nanohole to investigate the geometric parameters influence on the focusing properties of the plasmonic lens.

  18. The correct lens mount lightweighting design of thermal cycle stress in Cassegrain telescope

    Science.gov (United States)

    Hsu, M. Y.; Chang, S. T.; Huang, T. M.; Hsu, Ming-Ying

    2011-10-01

    The Cassegrain telescope system was design for space environment. The correct lens mount assembly is included as correct lens, lens mount, spacer, mount barrel and retainer. The system mass budget allocated to correct lens assembly was 5 Kg. Meanwhile, according to optical design the correct lens is made from fused silica, the lens diameter is 130 mm, and the mass is 2.3 Kg. Therefore, remain mass budget is 2.7 Kg; including the lens mount, spacer, mount barrel and retainer. The telescope system deformation is mainly caused by thermal deformation on space orbit. The correct lens mount was made from invar material in initial design. The CTE (Coefficient of Thermal Expansion) of invar is only 1* 10-6/°C, low CTE would be resistant to thermal deformation, but invar density is 8* 10-6 kg/mm3. If all components were made from invar, the total mass was over 2.7 kg. Thus, the components material would consider titanium alloy (CTE is 8.6* 10-6/°C, density is 4.43* 10-6 kg/mm3) or aluminum alloy (CTE is 23.6* 10-6/°C, density is 2.81* 10-6 kg/mm3). The titanium alloy density is 1.83 times lighter than invar, but CTE is 8.6 times higher. The aluminum alloy density is 2.84 times lighter then invar, but CTE is 23.6 times higher. The lens mount thermal deformation would effect correct lens surface wavefront error and introduce optical aberration. This article analyzes the correct lens assembly thermal deformation and optical performance in different lens mount material. From above conditions, using FEM (Finite Element Method) and optical software, simulation and optimization on the lens mount design have been performed to achieve system mass requirement.

  19. Development and test of a prototype for the PANDA barrel DIRC detector at FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Kalicy, Grzegorz

    2014-07-01

    The PANDA experiment at FAIR will perform world class physics studies using high-intensity cooled antiproton beams with momenta between 1.5 and 15 GeV/c. A rich physics program requires very good particle identification (PID). Charged hadron PID for the barrel section of the target spectrometer has to cover the angular range of 22-140 and separate pions from kaons for momenta up to 3.5 GeV/c with a separation power of at least 3 standard deviations. The system that will provide it has to be thin and operate in a strong magnetic field. A ring imaging Cherenkov detector using the DIRC principle meets those requirements. The design of the PANDA Barrel DIRC is based on the successful BABAR DIRC counter with several important changes to improve the performance and optimize the costs. The design options are being studied in detailed Monte Carlo simulation, and implemented in increasingly complex system prototypes and tested in particle beams. Before building the full system prototypes the radiator bars and lenses are measured on the test benches. The performance of the DIRC prototype was quantified in terms of the single photon Cherenkov angle resolution and the photon yield. Results for two full system prototypes will be presented. The prototype in 2011 aimed at investigating the full size expansion volume. It was found that the resolution for this configuration is at the level of in good agreement with ray tracing simulation results. A more complex prototype, tested in 2012, provided the first experience with a compact fused silica prism expansion volume, a wide radiator plate, and several advanced lens options for the focusing system. The performance of the baseline configuration of the prototype with a standard lens and an air gap met the requirements for the PANDA PID for most of the polar angle range but failed at polar angles around 90 due to photon loss at the air gap. Measurements with a prototype high-refractive index compound lens without an air gap at a polar

  20. Installation of CMS EB (ECAL Barrel) Supermodules 5 and 13 inside HB+ (HCAL Barrel) on 26/27 April 2006

    CERN Multimedia

    Ken Bell, RAL

    2006-01-01

    The first two barrel "supermodules" of the CMS Electromagnetic Calorimeter (ECAL) have been inserted into the barrel hadron calorimeter (HCAL) in the CMS experimental hall (called SX5) in Cessy in preparation for the forthcoming magnet test and cosmic challenge (MTCC). Each of the two supermodules contains 1700 lead tungstate crystals in glass-fibre alveolar support structures, with associated avalanche photodiodes (APDs, for scintillation light detection), electronics and cooling system. See also the document CMS-PHO-OREACH-2006-019. The first two pictures show the two supermodules in their final position. Fig. 3: the "enfourneur" in position on the HB Cradle. Fig. 4: supermodule n. 5 and extension rails being lifted to the enforneur. Figs. 5-6: supermodule approaching the enforneur. Fig. 7: rotating the Enfourneur to the correct phi direction Figs. 8-9: aligning the extension rails with the rails inside HB and view from inside HB, once the rails are aligned. Figs. 10-12: insertion of supermodule n. 5. Fig. ...

  1. Contact lens in keratoconus

    Directory of Open Access Journals (Sweden)

    Varsha M Rathi

    2013-01-01

    Full Text Available Contact lenses are required for the visual improvement in patients with keratoconus. Various contact lens options, such as rigid gas permeable (RGP lenses, soft and soft toric lenses, piggy back contact lenses (PBCL, hybrid lenses and scleral lenses are availble. This article discusses about selection of a lens depending on the type of keratoconus and the fitting philosophies of various contact lenses including the starting trial lens. A Medline search was carried out for articles in the English language with the keywords keratoconus and various contact lenses such as Rose k lens, RGP lens, hybrid lens, scleral lens and PBCL.

  2. Contact lens in keratoconus

    Science.gov (United States)

    Rathi, Varsha M; Mandathara, Preeji S; Dumpati, Srikanth

    2013-01-01

    Contact lenses are required for the visual improvement in patients with keratoconus. Various contact lens options, such as rigid gas permeable (RGP) lenses, soft and soft toric lenses, piggy back contact lenses (PBCL), hybrid lenses and scleral lenses are availble. This article discusses about selection of a lens depending on the type of keratoconus and the fitting philosophies of various contact lenses including the starting trial lens. A Medline search was carried out for articles in the English language with the keywords keratoconus and various contact lenses such as Rose k lens, RGP lens, hybrid lens, scleral lens and PBCL. PMID:23925325

  3. 3D Printing the ATLAS' barrel toroid

    CERN Document Server

    Goncalves, Tiago Barreiro

    2016-01-01

    The present report summarizes my work as part of the Summer Student Programme 2016 in the CERN IR-ECO-TSP department (International Relations – Education, Communication & Outreach – Teacher and Student Programmes). Particularly, I worked closely with the S’Cool LAB team on a science education project. This project included the 3D designing, 3D printing, and assembling of a model of the ATLAS’ barrel toroid. A detailed description of the project' development is presented and a short manual on how to use 3D printing software and hardware is attached.

  4. The CMS Barrel Muon Trigger Upgrade

    CERN Document Server

    Triossi, Andrea

    2017-01-01

    ABSTRACT: The increase of luminosity expected by LHC during Phase 1 will impose several constrains for rate reduction while maintaining high efficiency in the CMS Level 1 trigger system. The TwinMux system is the early layer of the muon barrel region that concentrates the information from different subdetectors DT, RPC and HO. It arranges and fan-out the slow optical trigger links from the detector chambers into faster links (10 Gbps) that are sent to the track finders. Results, from collision runs, that confirm the satisfactory operation of the trigger system up to the output of the barrel track finder, will be shown. SUMMARY: In view of the increase of luminosity during phase 1 upgrade of LHC, the muon trigger chain of the Compact Muon Solenoid (CMS) experiment underwent considerable improvements. The muon detector was designed for preserving the complementarity and redundancy of three separate muon detection systems, Cathode Strip Chambers (CSC), Drift Tubes (DT) and Resistive Plate Chambers (RPC), until ...

  5. Progress of the EM Barrel Presampler Assembly

    CERN Multimedia

    Hostachy, J.Y.

    The liquid argon barrel presampler is a separate detector which will be placed in front of the electromagnetic barrel calorimeter, in the same cryostat. It is made of 32×2 sectors, each of them being 3.1 m long, about 28 cm large and a few cm thick. Three countries are involved in its construction: France (ISN-Grenoble), Sweden (KTH-Stockholm) and Morocco (Universities: Hassan II Ain Chock-Casablanca and Mohamed V-Rabat, and CNESTEN-Rabat). The design of the presampler started ten years ago and the series production began at the end of the year 2000. Today two-thirds of the sectors are produced and validated. In November 2002, half the detector (i.e. 32 sectors), was inserted on the internal face of the first EM calorimeter wheel (see pictures). Despite the fact that only 0.4 mm was available between sectors, it was possible to insert them all without meeting major difficulties. This operation was led by a team of four people, the sectors being systematically tested after insertion in the wheel. The inserti...

  6. Cosmic Ray Data in TRT Barrel

    CERN Multimedia

    M. Hance

    "I had a great day in August when I went into SR1," said Daniel Froidevaux, former project leader of the ATLAS Transition Radiation Tracker, "not only had all SCT barrels arrived at CERN, but there were cosmic ray tracks seen in the TRT!" Daniel's excitement was mirrored by the rest of the TRT collaboration when, on July 29, the first cosmic ray tracks were seen in the barrel. Along with many others in the community, Daniel was quick to point out that this is the cumulative result of years of R&D, test beam work, and an intense installation and integration schedule. Indeed, the cosmic ray readout is only possible through the coordination of many efforts, from detector mechanics to module assembly, power and high voltage control, cooling, gas systems, electronics and cabling, data acquisition, and monitoring. "Many people have worked very hard on the the TRT, some of them for more than 10 years," said Brig Williams, the leader of the UPenn group responsible for much of the TRT front end electronics. He ...

  7. ATLAS TRT Barrel in Test Beam

    CERN Multimedia

    Luehring, F

    In July, the TRT group made a highly successful test of 6 Barrel TRT modules in the ATLAS H8 testbeam. Over 3000 TRT straw tubes (4 mm diameter gas drift tubes) were instrumented and found to operate well. The prototype represents 1/16 of the ATLAS TRT barrel and was assembled from TRT modules produced as spares. This was the largest scale test of the TRT to this date and the measured detector performance was as good as or better than what was expected in all cases. The 2004 TRT testbeam setup before final cabling was attached. The readout chain and central DAQ system used in the TRT testbeam is a final prototype for the ATLAS experiment. The TRT electronics used to read out the data were: The Amplifier/Shaper/Discriminator with Baseline Restoration (ASDBLR) chip is the front-end analog chip that shapes and discriminates the electronic pulses generated by the TRT straws. The Digital Time Measurement Read Out Chip (DTMROC) measures the time of the pulse relative to the beam crossing time. The TRT-ROD ...

  8. Modified suturing contact lens for penetrating keratoplasty.

    Science.gov (United States)

    Kramer, S G; Stewart, H L

    1978-11-01

    The authors have previously described a suturing contact lens that protects the corneal endothelium by aiding in the maintenance of the anterior chamber during penetrating keratoplasty. This report describes structural modifications of the suturing contact lens, which improve its stability and effectiveness. An additional configuration for use in corneal lacerations is presented.

  9. 27 CFR 25.144 - Rebranding barrels and kegs.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Rebranding barrels and kegs. 25.144 Section 25.144 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Marks, Brands, and Labels § 25.144 Rebranding barrels and...

  10. Construction, assembly and tests of the ATLAS electromagnetic barrel calorimeter

    CERN Document Server

    Aubert, B; Colas, Jacques; Delebecque, P; Di Ciaccio, L; El-Kacimi, M; Ghez, P; Girard, C; Gouanère, M; Goujdami, D; Jérémie, A; Jézéquel, S; Lafaye, R; Massol, N; Perrodo, P; Przysiezniak, H; Sauvage, G; Thion, J; Wingerter-Seez, I; Zitoun, R; Zolnierowski, Y; Alforque, R; Chen, H; Farrell, J; Gordon, H; Grandinetti, R; Hackenburg, R W; Hoffmann, A; Kierstead, J A; Köhler, J; Lanni, F; Lissauer, D; Ma, H; Makowiecki, D S; Müller, T; Norton, S; Radeka, V; Rahm, David Charles; Rehak, M; Rajagopalan, S; Rescia, S; Sexton, K; Sondericker, J; Stumer, I; Takai, H; Belymam, A; Benchekroun, D; Driouichi, C; Hoummada, A; Hakimi, M; Knee, Michael; Stroynowski, R; Wakeland, B; Datskov, V I; Drobin, V; Aleksa, Martin; Bremer, J; Carli, T; Chalifour, M; Chevalley, J L; Djama, F; Ema, L; Fabre, C; Fassnacht, P; Gianotti, F; Gonidec, A; Hansen, J B; Hervás, L; Hott, T; Lacaste, C; Marin, C P; Pailler, P; Pleskatch, A; Sauvagey, D; Vandoni, Giovanna; Vuillemin, V; Wilkens, H; Albrand, S; Belhorma, B; Collot, J; de Saintignon, P; Dzahini, D; Ferrari, A; Fulachier, J; Gallin-Martel, M L; Hostachy, J Y; Laborie, G; Ledroit-Guillon, F; Martin, P; Muraz, J F; Ohlsson-Malek, F; Saboumazrag, S; Viret, S; Othegraven, R; Zeitnitz, C; Banfi, D; Carminati, L; Cavalli, D; Citterio, M; Costa, G; Delmastro, M; Fanti, M; Mandelli, L; Mazzanti, M; Tartarelli, F; Augé, E; Baffioni, S; Bonis, J; Bonivento, W; Bourdarios, C; de La Taille, C; Fayard, L; Fournier, D; Guilhem, G; Imbert, P; Iconomidou-Fayard, L; Le Meur, G; Mencik, M; Noppe, J M; Parrour, G; Puzo, P; Rousseau, D; Schaffer, A C; Seguin-Moreau, N; Serin, L; Unal, G; Veillet, J J; Wicek, F; Zerwas, D; Astesan, F; Bertoli, W; Canton, B; Fleuret, F; Imbault, D; Lacour, D; Laforge, B; Schwemling, P; Abouelouafa, M; Ben-Mansour, A; Cherkaoui, R; El-Mouahhidi, Y; Ghazlane, H; Idrissi, A; Bazizi, K; England, D; Glebov, V; Haelen, T; Lobkowicz, F; Slattery, P F; Belorgey, J; Besson, N; Boonekamp, M; Durand, D; Ernwein, J; Mansoulié, B; Molinie, F; Meyer, J P; Perrin, P; Schwindling, J; Taguet, J P; Zaccone, Henri; Lund-Jensen, B; Rydström, S; Tayalati, Y; Botchev, B; Finocchiaro, G; Hoffman, J; McCarthy, R L; Rijssenbeek, M; Steffens, J; Zdrazil, M; Braun, H M

    2006-01-01

    The construction and assembly of the two half barrels of the ATLAS central electromagnetic calorimeter and their insertion into the barrel cryostat are described. The results of the qualification tests of the calorimeter before installation in the LHC ATLAS pit are given.

  11. Construction, assembly and tests of the ATLAS electromagnetic barrel calorimeter

    Science.gov (United States)

    Aubert, B.; Beaugiraud, B.; Colas, J.; Delebecque, P.; Di Ciaccio, L.; El Kacimi, M.; Ghez, P.; Girard, C.; Gouanère, M.; Goujdami, D.; Jeremie, A.; Jézéquel, S.; Lafaye, R.; Massol, N.; Perrodo, P.; Przysiezniak, H.; Sauvage, G.; Thion, J.; Wingerter-Seez, I.; Zitoun, R.; Zolnierowski, Y.; Alforque, R.; Chen, H.; Farrell, J.; Gordon, H.; Grandinetti, R.; Hackenburg, R.; Hoffmann, A.; Kierstead, J.; Koehler, J.; Lanni, F.; Lissauer, D.; Ma, H.; Makowiecki, D.; Muller, T.; Norton, S.; Radeka, V.; Rahm, D.; Rehak, M.; Rajagopalan, S.; Rescia, S.; Sexton, K.; Sondericker, J.; Stumer, I.; Takai, H.; Belymam, A.; Benchekroun, D.; Driouichi, C.; Hoummada, A.; Hakimi, M.; Knee, M.; Stroynowski, R.; Wakeland, B.; Datskov, V.; Drobin, V.; Aleksa, M.; Bremer, J.; Carli, T.; Chalifour, M.; Chevalley, J. L.; Djama, F.; Ema, L.; Fabre, C.; Fassnacht, P.; Gianotti, F.; Gonidec, A.; Hansen, J. B.; Hervas, L.; Hott, T.; Lacaste, C.; Marin, C. P.; Pailler, P.; Pleskatch, A.; Sauvage, D.; Vandoni, G.; Vuillemin, V.; Wilkens, H.; Albrand, S.; Belhorma, B.; Collot, J.; de Saintignon, P.; Dzahini, D.; Ferrari, A.; Fulachier, J.; Gallin-Martel, M. L.; Hostachy, J. Y.; Laborie, G.; Ledroit-Guillon, F.; Martin, P.; Muraz, J. F.; Ohlsson-Malek, F.; Saboumazrag, S.; Viret, S.; Othegraven, R.; Zeitnitz, C.; Banfi, D.; Carminati, L.; Cavalli, D.; Citterio, M.; Costa, G.; Delmastro, M.; Fanti, M.; Mandelli, L.; Mazzanti, M.; Tartarelli, F.; Augé, E.; Baffioni, S.; Bonis, J.; Bonivento, W.; Bourdarios, C.; De la Taille, C.; Fayard, L.; Fournier, D.; Guilhem, G.; Imbert, P.; Iconomidou-Fayard, L.; Le Meur, G.; Mencik, M.; Noppe, J.-M.; Parrour, G.; Puzo, P.; Rousseau, D.; Schaffer, A.-C.; Seguin-Moreau, N.; Serin, L.; Unal, G.; Veillet, J.-J.; Wicek, F.; Zerwas, D.; Astesan, F.; Bertoli, W.; Canton, B.; Fleuret, F.; Imbault, D.; Lacour, D.; Laforge, B.; Schwemling, Ph.; Abouelouafa, E. M.; Ben Mansour, A.; Cherkaoui, R.; El Mouahhidi, Y.; Ghazlane, H.; Idrissi, A.; Bazizi, K.; England, D.; Glebov, V.; Haelen, T.; Lobkowicz, F.; Slattery, P.; Belorgey, J.; Besson, N.; Boonekamp, M.; Durand, D.; Ernwein, J.; Mansoulié, B.; Molinié, F.; Meyer, J. P.; Perrin, P.; Schwindling, J.; Taguet, J. P.; Zaccone, H.; Lund-Jensen, B.; Rydström, S.; Tayalati, Y.; Botchev, B.; Finocchiaro, G.; Hoffman, J.; McCarthy, R. L.; Rijssenbeek, M.; Steffens, J.; Zdrazil, M.; Braun, H. M.

    2006-03-01

    The construction and assembly of the two half barrels of the ATLAS central electromagnetic calorimeter and their insertion into the barrel cryostat are described. The results of the qualification tests of the calorimeter before installation in the LHC ATLAS pit are given.

  12. Analysis of gun barrel rifling twist

    Science.gov (United States)

    Sun, Jia; Chen, Guangsong; Qian, Linfang; Liu, Taisu

    2017-05-01

    Aiming at the problem of gun barrel rifling twist, the constraint relation between rifling and projectile is investigated. The constraint model of rifling and projectile is established and the geometric relation between the twist and the motion of projectile is analyzed. Based on the constraint model, according to the rotating band that is fired, the stress and the motion law of the rotating band in bore are analyzed. The effects to rotating band (double rotating band or wide driving band) caused by different rifling (rib rifling, increasing rifling and combined rifling) are also investigated. The model is demonstrated by several examples. The results of numerical examples and the constraint mode show that the uncertainty factors will be brought in the increasing rifling and combined rifling during the projectile move in the bore. According to the amplitude and the strength of the twist acting on rotating band, the steady property of rotational motion of the projectile, the rib rifling is a better choose.

  13. Study of a twisted ATLAS SCT Barrel deformation as revealed by a photogrammetric survey

    CERN Document Server

    Dobson, E; Heinemann, F; Karagoz-Unel, M

    2007-01-01

    A photogrammetry survey on the SCT barrels was performed as an engineering check on the structure of the ATLAS Semiconductor Tracker (SCT) shortly after construction. Analysis of the data obtained revealed small scale elliptical deformation as well as a twist of the structure. The results of the survey are presented as well as interpolation of the measured targets to the module positions and a comparison with track based alignment measurements.

  14. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... lens because they can be purchased over-the-counter or on the Internet," says Thomas Steinemann, MD, ... Halloween Safety Colored Contact Lens Facts Over-the-Counter Costume Contacts May Contain Chemicals Harmful to Eyes ...

  15. The SNAP Strong Lens Survey

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, P.

    2005-01-03

    Basic considerations of lens detection and identification indicate that a wide field survey of the types planned for weak lensing and Type Ia SNe with SNAP are close to optimal for the optical detection of strong lenses. Such a ''piggy-back'' survey might be expected even pessimistically to provide a catalogue of a few thousand new strong lenses, with the numbers dominated by systems of faint blue galaxies lensed by foreground ellipticals. After sketching out our strategy for detecting and measuring these galaxy lenses using the SNAP images, we discuss some of the scientific applications of such a large sample of gravitational lenses: in particular we comment on the partition of information between lens structure, the source population properties and cosmology. Understanding this partitioning is key to assessing strong lens cosmography's value as a cosmological probe.

  16. Restoring lens capsule integrity enhances lens regeneration in New Zealand albino rabbits and cats.

    Science.gov (United States)

    Gwon, A; Gruber, L J; Mantras, C

    1993-11-01

    In studies conducted by numerous investigators for 150 years, lenses regenerated following endocapsular lens extraction in New Zealand albino rabbits have been irregular in shape, appearing primarily doughnut-shaped as a result of lack of lens growth at the site of the anterior capsulotomy and its adhesion to the posterior capsule. In the present study, we restored the lens capsule integrity by inserting a collagen patch at the time of surgery to seal the anterior capsulotomy and to improve the shape and structure of the regenerated lenses. We then filled the capsule bag with air to prevent adhesions between the anterior and posterior capsule and maintain capsule tautness and shape. Lens regeneration was first noted as early as one to two weeks. Regenerated lens filled approximately 50% of the capsule bag at two weeks and 100% by five weeks. Subsequent growth was in the anterior-posterior direction and measured by A-scan biometry. Lens thickness increased by 0.3 mm per month. The regenerated lenses were spherical with normal cortical structure and a nuclear opacity. In conclusion, restoration of lens capsular integrity with a collagen patch following endocapsular lens extraction enhanced the shape, structure, and growth rate of the regenerated lenses. In addition, lens regeneration was shown to occur in two cats.

  17. Comparison between two possible CMS Barrel Muon Readout Architectures

    International Nuclear Information System (INIS)

    Aguayo, P.; Barcala, J.M.; Molinero, A.; Pablos, J.L.; Willmott, C.; Alberdi, J.; Marin, J.; Navarrete, J.; Romero, L.

    1997-01-01

    A comparison between two possible readout arquitectures for the CMS muon barrel readout electronics is presented, including various aspects like costs, reliability, installation, staging and maintenance. A review of the present baseline architecture is given in the appendix. (Author)

  18. Tri-Service Green Gun Barrel (PP 1074)

    National Research Council Canada - National Science Library

    Rusch, Lawrence F

    2003-01-01

    ...) PP 1074 Tri-Service Green Gun Barrel. The program's goal was to develop an environmentally friendly process for depositing wear and erosion resistant materials onto gun bores replacing the current hazardous aqueous electro-deposition...

  19. Man-in-the-barrel syndrome: First CT images

    Energy Technology Data Exchange (ETDEWEB)

    Delavelle, J.; Lalanne, B.; Megret, M.

    1987-09-01

    A main-in-the-barrel syndrome occurred in a patient who suffered severe anaphylactic reaction after injection of chymopapain during chemonucleolysis. CT showed bilateral frontal watershed infarctions typically associated with this syndrome (Mohr and Sage).

  20. EXTERNAL BARREL TEMPERATURE OF A SMALL BORE OLYMPIC RIFLE

    Directory of Open Access Journals (Sweden)

    Bozena Gladyszewska

    2013-01-01

    Full Text Available Investigations on changes in a rifle’s barrel temperature during shooting in a rhythm typical for practitioners of Olympic shooting sports are presented. Walther KK300 (cal. 5.6 mm, a typical rifle often used in Olympic competitions, R50 RWS ammunition and a high speed thermographic camera were used in the study. Altair version 5 software was used to process thermal images and a stationary wavelet transform was applied to denoise signals for all the studied points. It was found that the temperature of the rifle barrel does not exceed 0.3°C after one shot whereas the total temperature increase does not exceed 5°C after taking 40 shots and does not affect the position of the hitting point on a target. In fact, contrary to popular belief, the so-called “warming shots” are not done for barrel heating but for cleaning of remnants in the barrel.

  1. First ATLAS Barrel Toroid coil casing arrives at CERN

    CERN Multimedia

    2002-01-01

    The first of eight 25-metre long coil casings for the ATLAS experiment's barrel toroid magnet system arrived at CERN on Saturday 2 March by road from Heidelberg. This structure will be part of the largest superconducting toroid magnet ever made.   The first coil casing for the toroidal magnets of Atlas arrives at Building 180. This is the start of an enormous three-dimensional jigsaw puzzle. Each of the eight sets of double pancake coils will be housed inside aluminium coil casings, which in turn will be held inside a stainless steel vacuum vessel. A huge construction, the casing that arrived at CERN measures 25 metres in length and 5 metres in width. It weighs 20 tones. And this is just the beginning of the toroid jigsaw: by early April a batch of four double pancake coils, which altogether weighs 65 tones, will arrive from Ansaldo in Italy. The first vacuum vessel will also be arriving from Felguera in Spain this month. It will take about two years for all these 25 m long structures of casings, coils a...

  2. REFRACTIVE NEUTRON LENS

    OpenAIRE

    Petrov, P. V.; Kolchevsky, N. N.

    2013-01-01

    Compound concave refractive lenses are used for focusing neutron beam. Investigations of spectral and focusing properties of a refractive neutron lens are presented. Resolution of the imaging system on the base of refractive neutron lenses depends on material properties and parameters of neutron source. Model of refractive neutron lens are proposed. Results of calculation diffraction resolution and focal depth of refractive neutron lens are discussed.

  3. Contact lens in keratoconus

    OpenAIRE

    Rathi, Varsha M; Mandathara, Preeji S; Dumpati, Srikanth

    2013-01-01

    Contact lenses are required for the visual improvement in patients with keratoconus. Various contact lens options, such as rigid gas permeable (RGP) lenses, soft and soft toric lenses, piggy back contact lenses (PBCL), hybrid lenses and scleral lenses are availble. This article discusses about selection of a lens depending on the type of keratoconus and the fitting philosophies of various contact lenses including the starting trial lens. A Medline search was carried out for articles in the En...

  4. Performances of the Coincidence Matrix ASIC of the ATLAS Barrel Level-1 Muon Trigger

    CERN Document Server

    Pastore, F; Vari, R; Veneziano, S

    2005-01-01

    The ATLAS Barrel Level-1 muon trigger handles data coming from the Resistive Plate Chamber detectors, structured in three concentric layers inside the air-core barrel toroid. The trigger classifies muons within different programmable transverse momentum thresholds, and tags the identified tracks with the corresponding bunch crossing number. The algorithm looks for hit coincidences within different detector layers inside the programmed geometrical road which defines the transverse momentum cut. The Coincidence Matrix ASIC implements the trigger algorithm and the readout of the RPC detector, processing hit signals coming from up to four detector layers. It finds muon track candidates and generates the output trigger patterns with a latency of a few 25 ns bunch crossing periods, and produces and time tags the readout hit patterns. Due to the different performance needs and limitations in the maximum power dissipation and technology, the CMA input pipeline and trigger logic and the time interpolator run at the wo...

  5. Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins.

    Science.gov (United States)

    Romero-Romero, Sergio; Costas, Miguel; Rodríguez-Romero, Adela; Alejandro Fernández-Velasco, D

    2015-08-28

    Temperature is one of the main variables that modulate protein function and stability. Thermodynamic studies of oligomeric proteins, the dominant protein natural form, have been often hampered because irreversible aggregation and/or slow reactions are common. There are no reports on the reversible equilibrium thermal unfolding of proteins composed of (β/α)8 barrel subunits, albeit this "TIM barrel" topology is one of the most abundant and versatile in nature. We studied the eponymous TIM barrel, triosephosphate isomerase (TIM), belonging to five species of different bacterial taxa. All of them were found to be catalytically efficient dimers. The three-dimensional structure of four enzymes was solved at high/medium resolution. Irreversibility and kinetic control were observed in the thermal unfolding of two TIMs, while for the other three the thermal unfolding was found to follow a two-state equilibrium reversible process. Shifts in the global stability curves of these three proteins are related to the organismal temperature range of optimal growth and modulated by variations in maximum stability temperature and in the enthalpy change at that temperature. Reversibility appears to correlate with the low isoelectric point, the absence of a residual structure in the unfolded state, small cavity volume in the native state, low conformational stability and a low melting temperature. Furthermore, the strong coupling between dimer dissociation and monomer unfolding may reduce aggregation and favour reversibility. It is therefore very thought-provoking to find that a common topological ensemble, such as the TIM barrel, can unfold/refold in the Anfinsen way, i.e. without the help of the cellular machinery.

  6. Tube entrance lens focus control

    Science.gov (United States)

    Weisser, D. C.; Fifield, L. K.; Kitchen, T. F. G.; Tunningley, T. B.; Lobanov, N. R.; Muirhead, A. G.

    2013-02-01

    The entrance of the accelerator tube in a large electrostatic accelerator imposes a strong lens that dominates the beam optics. The magnification of the lens is large because of the low injection energy, the high voltage gradient of the acceleration tube and the long distance to the terminal. In the absence of the acceleration, the magnification would produce an unacceptably large beam spot at the terminal. The tyranny of the lens is especially irksome when the accelerator is required to operate at a lower terminal voltage than the one corresponding to the nominal gradient at high voltage. One way around the difficulty, used in NEC Pelletron accelerators, is to insert a series of nylon and steel rods that short together units of the acceleration structure at the terminal leaving the ones near the entrance close to the nominal gradient for optimum transmission. This operation takes time and risks the loss of insulating gas. Another alternative used in the 25URC at Oak Ridge National Laboratory, is to focus the beam at the tube entrance, substantially diluting the effect of the entrance lens. The beam then diverges and so requires an additional lens part way to the terminal. This solution is only partially effective and still necessitates use of shorting rods for low voltage operation. The fact that these elaborate strategies are used is evidence that the alternative of lowering the injection energy as the terminal voltage is lowered imposes enough problems that it is not used in practice. We have modeled a solution that controls the voltage gradient at the tube entrance using an external power supply. This not only maintains the focusing effect of the lens but provides the opportunity to tune the beam by adjusting the entrance lens. A 150 kV power supply outside the pressure vessel feeds a controllable voltage through a high voltage feed-through to the fifth electrode of the accelerator tube. Thus 150 kV on this electrode creates the nominal gradient of 30 kV per

  7. Investigation of lens morphology and mechanical characteristics of lens capsule and lens nucleus in patients with agerelated and diabetic cataract

    Directory of Open Access Journals (Sweden)

    A. S. Tishkova

    2014-07-01

    Full Text Available Purpose: To investigate the influence of carbohydrate metabolism on the structure and mechanical properties of the lens capsule and nucleus.Methods: Human lens pathology was studied in different forms of cataract. 220 patients with a cataract (220 eyes were included in this study. Morphological, immunohystological and immunocytochemical investigations of lens substance (antibodies to a- (a-А and a-В, b-, g- crystallines, spectroscopic analyses of smears and morphometric analyses of slices, investigation of lens morphology and mechanical caracteristics of lens capsule and lens nucleus were performed.Results: The capsule of the lens in patients with senile cataract contains more Na+, Cl-. The capsule of the lens in patients with senile cataract contains more Ca2+, O. Mechanical strength of the capsule in the case of diabetes mellitus was lower comparatively with senile cataract in the same age groups. More significant expression of a-В and b-crystallines was found in patients with diabetes mellitus comparatively with patients with age-related cataract. Morphological features were founded in patients with cortical and nuclear forms of senile cataract and the diabetic cataract.Conclusion: During surgery (ultrasonic microcoaxial phacoemulsification the equivalent of ultrasound was recorded. Lower density of the lens nucleus of patients with diabetes mellitus made it possible to use lower energy parameters. Using the torsion ultrasound in those cases allowed us to decrease the influence of ultrasound on eye tissues and reduce the time of achieving the maximum BCVA in the postsurgical period.

  8. Investigation of lens morphology and mechanical characteristics of lens capsule and lens nucleus in patients with agerelated and diabetic cataract

    Directory of Open Access Journals (Sweden)

    A. S. Tishkova

    2013-01-01

    Full Text Available Purpose: To investigate the influence of carbohydrate metabolism on the structure and mechanical properties of the lens capsule and nucleus.Methods: Human lens pathology was studied in different forms of cataract. 220 patients with a cataract (220 eyes were included in this study. Morphological, immunohystological and immunocytochemical investigations of lens substance (antibodies to a- (a-А and a-В, b-, g- crystallines, spectroscopic analyses of smears and morphometric analyses of slices, investigation of lens morphology and mechanical caracteristics of lens capsule and lens nucleus were performed.Results: The capsule of the lens in patients with senile cataract contains more Na+, Cl-. The capsule of the lens in patients with senile cataract contains more Ca2+, O. Mechanical strength of the capsule in the case of diabetes mellitus was lower comparatively with senile cataract in the same age groups. More significant expression of a-В and b-crystallines was found in patients with diabetes mellitus comparatively with patients with age-related cataract. Morphological features were founded in patients with cortical and nuclear forms of senile cataract and the diabetic cataract.Conclusion: During surgery (ultrasonic microcoaxial phacoemulsification the equivalent of ultrasound was recorded. Lower density of the lens nucleus of patients with diabetes mellitus made it possible to use lower energy parameters. Using the torsion ultrasound in those cases allowed us to decrease the influence of ultrasound on eye tissues and reduce the time of achieving the maximum BCVA in the postsurgical period.

  9. Structural Conditions for Collaboration and Learning in Innovation Networks: Using an Innovation System Performance Lens to Analyse Agricultural Knowledge Systems

    NARCIS (Netherlands)

    Hermans, F.; Klerkx, L.W.A.; Roep, D.

    2015-01-01

    Purpose: We investigate how the structural conditions of eight different European agricultural innovation systems can facilitate or hinder collaboration and social learning in multidisciplinary innovation networks. Methodology: We have adapted the Innovation System Failure Matrix to investigate the

  10. Prioritizing targets for structural biology through the lens of proteomics: the archaeal protein TGAM_1934 from Thermococcus gammatolerans.

    Science.gov (United States)

    Yang, Yin-Shan; Fernandez, Bernard; Lagorce, Arnaud; Aloin, Valérie; De Guillen, Karine Montet; Boyer, Jean-Baptiste; Dedieu, Alain; Confalonieri, Fabrice; Armengaud, Jean; Roumestand, Christian

    2015-01-01

    ORFans are hypothetical proteins lacking any significant sequence similarity with other proteins. Here, we highlighted by quantitative proteomics the TGAM_1934 ORFan from the hyperradioresistant Thermococcus gammatolerans archaeon as one of the most abundant hypothetical proteins. This protein has been selected as a priority target for structure determination on the basis of its abundance in three cellular conditions. Its solution structure has been determined using multidimensional heteronuclear NMR spectroscopy. TGAM_1934 displays an original fold, although sharing some similarities with the 3D structure of the bacterial ortholog of frataxin, CyaY, a protein conserved in bacteria and eukaryotes and involved in iron-sulfur cluster biogenesis. These results highlight the potential of structural proteomics in prioritizing ORFan targets for structure determination based on quantitative proteomics data. The proteomic data and structure coordinates have been deposited to the ProteomeXchange with identifier PXD000402 (http://proteomecentral.proteomexchange.org/dataset/PXD000402) and Protein Data Bank under the accession number 2mcf, respectively. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex

    Directory of Open Access Journals (Sweden)

    Annabella Pignataro

    2015-01-01

    Full Text Available Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits. Although cAMP response element binding protein (CREB has a key function in spines changes, its role in activity-dependent rearrangements in brain regions of rodents interacting with the surrounding environment has received little attention so far. Here we studied the effects of vibrissae trimming, a widely used model of sensory deprivation-induced cortical plasticity, on processes associated with dendritic spine rearrangements in the barrel cortex of a transgenic mouse model of CREB downregulation (mCREB mice. We found that sensory deprivation through prolonged whisker trimming leads to an increased number of thin spines in the layer V of related barrel cortex (Contra in wild type but not mCREB mice. In the barrel field controlling spared whiskers (Ipsi, the same trimming protocol results in a CREB-dependent enlargement of dendritic spines. Last, we demonstrated that CREB regulates structural rearrangements of synapses that associate with dynamic changes of dendritic spines. Our findings suggest that CREB plays a key role in dendritic spine dynamics and synaptic circuits rearrangements that account for new brain connectivity in response to changes in the environment.

  12. A review on the gun barrel vibrations and control for a main battle tank

    Directory of Open Access Journals (Sweden)

    Tolga Dursun

    2017-10-01

    Full Text Available Achieving high hitting accuracy for a main battle tank is challenging while the tank is on the move. This can be reached by proper design of a weapon control and gun system. In order to design an effective gun system while the tank is moving, better understanding of the dynamic behavior of the gun system is required. In this study, the dynamic behaviour of a gun system is discussed in this respect. Both experimental and numerical applications for the determination of the dynamic behaviour of a tank gun system are investigated. Methods such as the use of muzzle reference system (MRS and vibration absorbers, and active vibration control technology for the control and the reduction of the muzzle tip deflections are also reviewed. For the existing gun systems without making substantial modifications, MRS could be useful in controlling the deflections of gun barrels with estimation/prediction algorithms. The vibration levels could be cut into half by the use of optimised vibration absorbers for an existing gun. A new gun system with a longer barrel can be as accurate as the one with a short barrel with the appropriate structural modifications.

  13. Functions of phenylalanine residues within the beta-barrel stem of the anthrax toxin pore.

    Directory of Open Access Journals (Sweden)

    Jie Wang

    2009-07-01

    Full Text Available A key step of anthrax toxin action involves the formation of a protein-translocating pore within the endosomal membrane by the Protective Antigen (PA moiety. Formation of this transmembrane pore by PA involves interaction of the seven 2beta2-2beta3 loops of the heptameric precursor to generate a 14-strand transmembrane beta barrel.We examined the effects on pore formation, protein translocation, and cytotoxicity, of mutating two phenylalanines, F313 and F314, that lie at the tip the beta barrel, and a third one, F324, that lies part way up the barrel.Our results show that the function of these phenylalanine residues is to mediate membrane insertion and formation of stable transmembrane channels. Unlike F427, a key luminal residue in the cap of the pore, F313, F314, and F324 do not directly affect protein translocation through the pore. Our findings add to our knowledge of structure-function relationships of a key virulence factor of the anthrax bacillus.

  14. Structural Conditions for Collaboration and Learning in Innovation Networks: Using an Innovation System Performance Lens to Analyse Agricultural Knowledge Systems

    Science.gov (United States)

    Hermans, Frans; Klerkx, Laurens; Roep, Dirk

    2015-01-01

    Purpose: We investigate how the structural conditions of eight different European agricultural innovation systems can facilitate or hinder collaboration and social learning in multidisciplinary innovation networks. Methodology: We have adapted the Innovation System Failure Matrix to investigate the main barriers and enablers eight countries…

  15. Particle swarm optimization applied to automatic lens design

    Science.gov (United States)

    Qin, Hua

    2011-06-01

    This paper describes a novel application of Particle Swarm Optimization (PSO) technique to lens design. A mathematical model is constructed, and merit functions in an optical system are employed as fitness functions, which combined radiuses of curvature, thicknesses among lens surfaces and refractive indices regarding an optical system. By using this function, the aberration correction is carried out. A design example using PSO is given. Results show that PSO as optical design tools is practical and powerful, and this method is no longer dependent on the lens initial structure and can arbitrarily create search ranges of structural parameters of a lens system, which is an important step towards automatic design with artificial intelligence.

  16. Treatment Method for Fermi Barrel Sodium Metal Residues

    Energy Technology Data Exchange (ETDEWEB)

    Steven R. Sherman; Collin J. Knight

    2005-06-01

    Fermi barrels are 55-gallon drums that once contained bulk sodium metal from the shutdown Fermi 1 breeder reactor facility, and now contain residual sodium metal and other sodium/air reaction products. This report provides a residual sodium treatment method and proposed quality assurance steps that will ensure that all residual sodium is deactivated and removed from the Fermi barrels before disposal. The treatment method is the application of humidified carbon dioxide to the residual sodium followed by a water wash. The experimental application of the treatment method to six Fermi barrels is discussed, and recommendations are provided for further testing and evaluation of the method. Though more testing would allow for a greater refinement of the treatment technique, enough data has been gathered from the tests already performed to prove that 100% compliance with stated waste criteria can be achieved.

  17. Mechanical Commissioning of the ATLAS Barrel Toroid Magnet

    CERN Document Server

    Foussat, A; Dudarev, A; Bajas, H; Védrine, P; Berriaud, C; Sun, Z; Sorbi, M

    2008-01-01

    ATLAS is a general-purpose detector designed to run at the highest luminosity at the CERN Large Hadron Collider. Its features include the 4 T Barrel Toroid magnet, the largest superconducting magnet (25 m long, 20 m diameter) that provides the magnetic field for the ATLAS muon spectrometer. The coils integrated at CERN, were tested individually at maximum current of 22 kA in 2005. Following the mechanical assembly of the Barrel Toroid in the ATLAS underground cavern, the test of the full Barrel Toroid was performed in October 2006. Further tests are foreseen at the end 2007 when the system will include the two End Cap Toroids (ECT). The paper gives an overview of the good mechanical test results achieved in comparison with model predictions and the experience gained in the mechanical behavior of the ATLAS Toroidal coils is discussed.

  18. A monodisperse transmembrane α-helical peptide barrel

    Science.gov (United States)

    Mahendran, Kozhinjampara R.; Niitsu, Ai; Kong, Lingbing; Thomson, Andrew R.; Sessions, Richard B.; Woolfson, Derek N.; Bayley, Hagan

    2017-05-01

    The fabrication of monodisperse transmembrane barrels formed from short synthetic peptides has not been demonstrated previously. This is in part because of the complexity of the interactions between peptides and lipids within the hydrophobic environment of a membrane. Here we report the formation of a transmembrane pore through the self-assembly of 35 amino acid α-helical peptides. The design of the peptides is based on the C-terminal D4 domain of the Escherichia coli polysaccharide transporter Wza. By using single-channel current recording, we define discrete assembly intermediates and show that the pore is most probably a helix barrel that contains eight D4 peptides arranged in parallel. We also show that the peptide pore is functional and capable of conducting ions and binding blockers. Such α-helix barrels engineered from peptides could find applications in nanopore technologies such as single-molecule sensing and nucleic-acid sequencing.

  19. Computer Simulation of the Cool Down of the ATLAS Liquid Argon Barrel Calorimeter

    CERN Document Server

    Korperud, N; Fabre, C; Owren, G; Passardi, Giorgio

    2002-01-01

    The ATLAS electromagnetic barrel calorimeter consists of a liquid argon detector with a total mass of 120 tonnes. This highly complicated structure, fabricated from copper, lead, stainless steel and glass-fiber reinforced epoxy will be placed in an aluminum cryostat. The cool down process of the detector will be limited by the maximum temperature differences accepted by the composite structure so as to avoid critical mechanical stresses. A computer program simulating the cool down of the detector by calculating the local heat transfer throughout a simplified model has been developed. The program evaluates the cool down time as a function of different contact gasses filling the spaces within the detector.

  20. Role of Aquaporin 0 in lens biomechanics

    Energy Technology Data Exchange (ETDEWEB)

    Sindhu Kumari, S.; Gupta, Neha [Physiology and Biophysics, Stony Brook University, Stony Brook, NY (United States); Shiels, Alan [Washington University School of Medicine, St. Louis, MO (United States); FitzGerald, Paul G. [Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA (United States); Menon, Anil G. [University of Cincinnati College of Medicine, Cincinnati, OH (United States); Mathias, Richard T. [Physiology and Biophysics, Stony Brook University, Stony Brook, NY (United States); SUNY Eye Institute, NY (United States); Varadaraj, Kulandaiappan, E-mail: kulandaiappan.varadaraj@stonybrook.edu [Physiology and Biophysics, Stony Brook University, Stony Brook, NY (United States); SUNY Eye Institute, NY (United States)

    2015-07-10

    Maintenance of proper biomechanics of the eye lens is important for its structural integrity and for the process of accommodation to focus near and far objects. Several studies have shown that specialized cytoskeletal systems such as the beaded filament (BF) and spectrin-actin networks contribute to mammalian lens biomechanics; mutations or deletion in these proteins alters lens biomechanics. Aquaporin 0 (AQP0), which constitutes ∼45% of the total membrane proteins of lens fiber cells, has been shown to function as a water channel and a structural cell-to-cell adhesion (CTCA) protein. Our recent ex vivo study on AQP0 knockout (AQP0 KO) mouse lenses showed the CTCA function of AQP0 could be crucial for establishing the refractive index gradient. However, biomechanical studies on the role of AQP0 are lacking. The present investigation used wild type (WT), AQP5 KO (AQP5{sup −/−}), AQP0 KO (heterozygous KO: AQP0{sup +/−}; homozygous KO: AQP0{sup −/−}; all in C57BL/6J) and WT-FVB/N mouse lenses to learn more about the role of fiber cell AQPs in lens biomechanics. Electron microscopic images exhibited decreases in lens fiber cell compaction and increases in extracellular space due to deletion of even one allele of AQP0. Biomechanical assay revealed that loss of one or both alleles of AQP0 caused a significant reduction in the compressive load-bearing capacity of the lenses compared to WT lenses. Conversely, loss of AQP5 did not alter the lens load-bearing ability. Compressive load-bearing at the suture area of AQP0{sup +/−} lenses showed easy separation while WT lens suture remained intact. These data from KO mouse lenses in conjunction with previous studies on lens-specific BF proteins (CP49 and filensin) suggest that AQP0 and BF proteins could act co-operatively in establishing normal lens biomechanics. We hypothesize that AQP0, with its prolific expression at the fiber cell membrane, could provide anchorage for cytoskeletal structures like BFs and

  1. A Methodology for Characterizing Gun Barrel Flexure due to Vehicle Motion

    Directory of Open Access Journals (Sweden)

    Mark Bundy

    2001-01-01

    Full Text Available Barrel centerline curvature is known to influence the location of projectile shot impacts. Superimposed on the unique manufactured barrel centerline is the flexed barrel shape that can occur prior to firing while the vehicle is on the move. In order to understand and quantify the effects of barrel flexure on gun accuracy, it is necessary to determine what combination of fundamental mode shapes is most likely to occur. A method to accomplish this task is described in this paper. The method is demonstrated by enumerating the 10 most likely flexed barrel shapes that were found to occur in a tank-mounted gun barrel while it traversed a bump course.

  2. Photonic crystal based polarization insensitive flat lens

    Science.gov (United States)

    Turduev, M.; Bor, E.; Kurt, H.

    2017-07-01

    The paper proposes a new design of an inhomogeneous artificially created photonic crystal lens structure consisting of annular dielectric rods to efficiently focus both transverse electric and transverse magnetic polarizations of light into the same focal point. The locations of each individual cell that contains the annular dielectric rods are determined according to a nonlinear distribution function. The inner and outer radii of the annular photonic dielectric rods are optimized with respect to the polarization insensitive frequency response of the transmission spectrum of the lens structure. The physical background of the polarization insensitive focusing mechanism is investigated in both spatial and frequency domains. Moreover, polarization independent wavefront transformation/focusing has been explored in detail by investigating the dispersion relation of the structure. Corresponding phase index distribution of the lens is attained for polarization insensitive normalized frequency range of a/λ  =  0.280 and a/λ  =  0.300, where a denotes the lattice constant of the designed structure and λ denotes the wavelength of the incident light. We show the wave transformation performance and focal point movement dynamics for both polarizations of the lens structure by specially adjusting the length of the structure. The 3D finite-difference time domain numerical analysis is also performed to verifiy that the proposed design is able to focus the wave regardless of polarization into approximately the same focal point (difference between focal distances of both polarizations stays below 0.25λ) with an operating bandwidth of 4.30% between 1476 nm and 1541 nm at telecom wavelengths. The main superiorities of the proposed lens structure are being all dielectric and compact, and having flat front and back surfaces, rendering the proposed lens design more practical in the photonic integration process in various applications such as optical switch

  3. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... One Use Facts About Colored Contacts and Halloween Safety Colored Contact Lens Facts Over-the-Counter Costume ... new application of artificial intelligence shows whether a patient’s eyes point to high blood pressure or risk ...

  4. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... be purchased over-the-counter or on the Internet," says Thomas Steinemann, MD, professor of ophthalmology at ... ask for a prescription. There is no such thing as a "one size fits all" contact lens. ...

  5. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... had not been properly fitted by an eye care professional, the lenses stuck to my eye like ... lenses do not require the same level of care or consideration as a standard contact lens because ...

  6. Colored Contact Lens Dangers

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    Full Text Available ... sell contacts without a prescription are breaking the law, and may be fined $11,000 per violation. " ... wear any kind of contact lens. In Butler's case, the lenses caused an infection and left her ...

  7. Colored Contact Lens Dangers

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    Full Text Available ... One Use Facts About Colored Contacts and Halloween Safety Colored Contact Lens Facts Over-the-Counter Costume ... Costume Contact Lenses Can Ruin Vision Eye Makeup Safety In fact, it is illegal to sell colored ...

  8. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... with Colored Contact Lenses Julian: Teenager Blinded In One Eye By Non-Prescription Contact Lens Laura: Vision ... Robyn: Blurry Vision and Daily Eye Drops After One Use Facts About Colored Contacts and Halloween Safety ...

  9. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... One Use Facts About Colored Contacts and Halloween Safety Colored Contact Lens Facts Over-the-Counter Costume ... Academy Jobs at the Academy Financial Relationships with Industry Medical Disclaimer Privacy Policy Terms of Service For ...

  10. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... in a pair of colored contact lenses, Laura Butler of Parkersburg, W.Va., had "extreme pain in ... to wear any kind of contact lens. In Butler's case, the lenses caused an infection and left ...

  11. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... One Use Facts About Colored Contacts and Halloween Safety Colored Contact Lens Facts Over-the-Counter Costume ... use of colored contact lenses , from the U.S. Food and Drug Administration (FDA). Are the colored lenses ...

  12. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... an impulsive buy from a souvenir shop, but 10 hours after she first put in a pair ... Prescription Contact Lens Laura: Vision Loss After Just 10 Hours Robyn: Blurry Vision and Daily Eye Drops ...

  13. bubble chamber lens

    CERN Multimedia

    Before the days of electronic detectors, visual techniques were used to detect particles, using detectors such as spark chambers and bubble chambers. This plexiglass lens was used to focus the image of tracks so they could be photographed.

  14. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... Contact Lens Facts Over-the-Counter Costume Contacts May Contain Chemicals Harmful to Eyes Four Ways Over- ... without a prescription are breaking the law, and may be fined $11,000 per violation. "Many of ...

  15. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... not require the same level of care or consideration as a standard contact lens because they can ... sell contacts without a prescription are breaking the law, and may be fined $11,000 per violation. " ...

  16. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... One Use Facts About Colored Contacts and Halloween Safety Colored Contact Lens Facts Over-the-Counter Costume ... an ophthalmologist — an eye medical doctor — who will measure each eye and talk to you about proper ...

  17. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... prescription. Follow the contact lens care directions for cleaning, disinfecting, and wearing the lenses. Never share contact ... with Industry Medical Disclaimer Privacy Policy Terms of Service For Advertisers For Media Ophthalmology Job Center © American ...

  18. 2D fluid flow in the downcomer and dynamic response of the core barrel during PWR blowdown

    International Nuclear Information System (INIS)

    Katz, F.; Krieg, R.; Ludwig, A.; Schlechtendahl, E.G.; Stoelting, K.

    1977-01-01

    As a part of the HDR program, methods for coupled fluid-structural dynamics are being developed. On the fluid side the 2D finite difference code YAQUI has been modified (it became YAQUIR) and adapted to describe the fluid dynamics in the downcomer of PWR's. On the structural side for determination of the dynamic core barrel response the code CYLDY2 has been developed. In this code the core barrel is treated as a thin cylindrical shell fixed at the upper end and ring stiffened at the lower end. The mass of the lower end ring also simulated a part of the core mass. Both models have been successfully tested. Coupling has been achieved for a simplified structural model proving the correctness of the coupling procedure. The structural model CYLDY2 is based on Fluegge's shell equations and uses variational principles. The solution is a superposition of steady-state and transient eigenfunctions. Results indicate that for the relatively thin-walled core barrel of the HDR-experiments in most cases the local deformations are somewhat higher than the global deformation (beam model). The coupling of YAQUIR and CYLDY2 is performed by imbedding the structural model in the fluid model. Fluid velocities are parallel to the fluid/structure interface. The structure desplacements define the time and space dependent thickness of the two-dimensional fluid layer (2 1/2-dimensional model)

  19. TP0326, a Treponema pallidum β-Barrel Assembly Machinery A (BamA) Ortholog and Rare Outer Membrane Protein

    Science.gov (United States)

    Desrosiers, Daniel C.; Anand, Arvind; Luthra, Amit; Dunham-Ems, Star M; LeDoyt, Morgan; Cummings, Michael A. D.; Eshghi, Azad; Cameron, Caroline E.; Cruz, Adriana R.; Salazar, Juan C.; Caimano, Melissa J.; Radolf, Justin D.

    2011-01-01

    SUMMARY Definitive identification of Treponema pallidum (Tp) rare outer membrane proteins (OMPs) has long eluded researchers. TP0326, the sole protein in Tp with sequence homology to a Gram-negative OMP, belongs to the BamA family of proteins essential for OM biogenesis. Structural modeling predicted that five polypeptide transport-associated (POTRA) domains comprise the N-terminus of TP0326, while the C-terminus forms an 18-stranded amphipathic β-barrel. Circular dichroism, heat-modifiability by SDS-PAGE, Triton X-114 phase partitioning and liposome incorporation supported these topological predictions and confirmed that the β-barrel is responsible for the native protein's amphiphilicity. Expression analyses revealed that native TP0326 is expressed at low abundance, while a protease-surface accessibility assay confirmed surface exposure. Size-exclusion chromatography and blue native polyacrylamide gel electrophoresis revealed a modular Bam complex in Tp considerably larger than that of E. coli. Non-orthologous ancillary factors and self-association of TP0326 via its β-barrel may both contribute to the Bam complex. Tp-infected rabbits mount a vigorous antibody response to both POTRA and β-barrel portions of TP0326, whereas humans with secondary syphilis respond predominantly to POTRA. The syphilis spirochete appears to have devised a stratagem for harnessing the Bam pathway while satisfying its need to limit surface antigenicity. PMID:21488980

  20. New results in meson spectroscopy from the crystal barrel experiment

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, C.A. [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    1994-04-01

    Recent observations by the Crystal Barrel experiment of two scalar resonances, f{sub o}(1365) and a{sub o}(1450) have allowed the authors to clarify the members of the scalar nonet. In addition, a third scalar, f{sub o}(1500), appears to be supernumerary, and is a candidate for the scalar glueball expected near 1500 MeV.

  1. The barrel modules of the ATLAS semiconductor tracker

    Czech Academy of Sciences Publication Activity Database

    Abdesselam, A.; Akimoto, T.; Allport, P.; Böhm, Jan; Šťastný, Jan

    2006-01-01

    Roč. 568, - (2006), s. 642-671 ISSN 0168-9002 Institutional research plan: CEZ:AV0Z10100502 Keywords : ATLAS * SCT * silicon * microstrip * module * LHC * barrel Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.185, year: 2006

  2. Experiences developing socially acceptable interactions for a robotic trash barrel

    DEFF Research Database (Denmark)

    Yang, Stephen; Mok, Brian Ka Jun; Sirkin, David

    2015-01-01

    strategies that seemed to evoke clear engagement and responses, both positive and negative. Observations and interviews show that a) people most welcome the robot's presence when they need its services and it actively advertises its intent through movement; b) people create mental models of the trash barrel...

  3. Results of 3D photogrammetry on the CMS barrel yoke

    Energy Technology Data Exchange (ETDEWEB)

    Goudard, R.; Humbertclaude, C.; Nummiaro, K. [CERN, Conseil Europeen pour la recherche nucleaire, Laboratoire europeen pour la physique des particules, Geneve (Switzerland)

    1999-07-01

    The CMS (Compact Muon Solenoid) detector of the new LHC will be built till 2005 at CERN in Geneva. The Barrel Yoke survey has been decided to be done mostly by photogrammetry. After this first measurement, it has been proved that a practical simulation and a study of adapted tools and procedures were helpful for measurement on such a large object. Using only conventional surveying methods would have been impossible with such constraints. The most important points were the high required accuracy compared to the size of the object, the connection of the two planes, the time intervention, the restricted factory environment and the impossibility for having any outside network. The photogrammetric method was considered to be the best way to survey the Barrel Yoke ring. Since the required precision has been reached at all levels with the first full Barrel measurements, the procedure is validated for the four remaining Barrels in the factory and afterwards again at CERN. This project was challenging due to the size of the object, the required accuracy and the lack of practical references in the field of digital industrial photogrammetry. This method is a new step for using the three dimensional photogrammetric measurements on large objects. (authors)

  4. barrel temperature emperature emperature effects on the ffects

    African Journals Online (AJOL)

    eobe

    Keywords: barrel temperature,plastic products, injection moulding machine , tensile strength, flexual strength. 1. INTRODUCTION. INTRODUCTION. INTRODUCTION. The utilization of process control and process monitoring are rarely fully implemented for the production of injection moulded products. This may be due to a ...

  5. End of the EM Barrel Presampler Construction and Insertion

    CERN Multimedia

    Hostachy, J.Y.

    The liquid argon barrel presampler is a thin detector placed in front of the electromagnetic barrel calorimeter, made up of two half barrels also, but with 32 sectors per half barrel instead of 16. Each of these 64 sectors is 3.1 m long, 28 cm large and 2.9 cm thick. Three countries took part in its construction: France (LPSC-Grenoble), Sweden (KTH-Stockholm) and Morocco (Hassan II Ain Chock-Casablanca and Mohamed V-Rabat universities, and CNESTEN-Rabat). The design of the presampler started 11 years ago and the series production began at the end of 2000. Cabling, mechanical and electronic tests of the anodes were achieved in Morocco. Forty-one sectors were assembled and validated at the LPSC-Grenoble and 25 at the KTH-Stockholm. In November 2002, the first half was inserted on the inner face of the first EM calorimeter wheel. The insertion of the other 32 sectors in the second EM calorimeter wheel was achieved in July 2003 (see pictures). The production of two additional sectors will allow us to study the p...

  6. LOCALIZATION OF NMDA AND AMPA RECEPTORS IN RAT BARREL FIELD

    NARCIS (Netherlands)

    JAARSMA, D; SEBENS, JB; KORF, J

    1991-01-01

    The aim of this study was to asses the distribution of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-S-methyl-4-isoxazole propionic acid (AMPA) receptors in the barrel field of rat primary somatosensory (SI) cortex using light-microscopic in vitro autoradiography. NMDA receptors were labeled

  7. ATLAS barrel hadron tile calorimeter: spacers plates mass production

    International Nuclear Information System (INIS)

    Artikov, A.M.; Budagov, Yu.A.; Khubua, J.

    1999-01-01

    In this article we expose the main problems of the mass production of the so-called 'spacer plates' for the ATLAS Barrel Hadron Tile Calorimeter. We describe all practical solutions of these problems. Particularly we present the measurement procedures and calculation schemes we used for the spacers dimensions determination. The results of the calculations are presented

  8. Signal feedthroughs for the ATLAS barrel and endcap calorimeters

    CERN Document Server

    Axen, D A; Hoffman, A; Kane, S; Lissauer, D; Makowiecki, D S; Müller, T; Pate, D; Radeka, V; Rahm, David Charles; Rehak, M; Rescia, S; Sexton, K; Sondericker, J; Birney, P; Dowling, A W; Fincke-Keeler, M; Hodges, T; Holness, F; Honkanen, N; Keeler, R; Langstaf, R; Lenckowski, M; Lefebvre, M; Poffenberger, P R; Vowles, G

    2005-01-01

    The construction of the signal feedthroughs for the barrel and endcap ATLAS liquid argon calorimeters is described. The feedthroughs provide a high density and radiation hard method to extract signals from the cryogenic environment of the calorimeters using a novel design based on flexible kapton circuit board transmission lines.

  9. Experimental investigation on shore hardness of barrel-finished ...

    Indian Academy of Sciences (India)

    Barrel finishing (BF) process is widely used to improve the surface finish and dimensional features of metallic and non-metallic parts using different types of media. As a matter of fact the change in shore hardness (SH) features of fused deposition modelling (FDM)-based master pattern is one of the important considerations ...

  10. Conceptual design for the STAR barrel electromagnetic calorimeter support rings

    International Nuclear Information System (INIS)

    Bielick, E.; Fornek, T.; Spinka, H.; Underwood, D.

    1994-01-01

    The STAR electromagnetic calorimeter (EMC) will be used to measure the energy of photons and electrons from collisions of beams of particles in the RHIC accelerator under construction at Brookhaven National Laboratory. The present design is documented in the EMC Conceptual Design Report, and consists of a cylindrical barrel and two flat endcap calorimeter sections. The barrel EMC will consist of 120 modules, each subtending 6 degrees in azimuthal angle about the beam (φ), and half the barrel length. Each module will be subdivided into ''towers'' of alternating scintillator and lead, which project to the nominal interaction point. There is a strong coupling between the designs for the EMC and for the conventional solenoidal magnet, which will be located immediately outside the barrel EMC. For example, the inner radius of the magnet must be minimized to lower costs and to reduce the STAR detector's outer diameter to fit within constraints of the existing detector building. This condition requires the calorimeter modules to be just thick enough to accomplish physics goals and to support their weight with small deflections. This note describes progress in the design of the EMC support rings. Several ring designs and methods of construction have been considered. In addition, installation and alignment problems for both the rings and the rails have been considered in more depth. Finally, revised stress calculations for the recommended ring designs have been performed. Most of this work has been done in close collaboration with the STAR magnet subgroup

  11. Resilience to disturbance despite limited dispersal and self-recruitment in tropical barrel sponges: implications for conservation and management.

    Science.gov (United States)

    Bell, James J; Smith, David; Hannan, Danielle; Haris, Abdul; Jompa, Jamaludin; Thomas, Luke

    2014-01-01

    While estimates of connectivity are important for effective management, few such estimates are available for reef invertebrates other than for corals. Barrel sponges are one of the largest and most conspicuous members of the coral reef fauna across the Indo-Pacific and given their large size, longevity and ability to process large volumes of water, they have a major role in reef functioning. Here we used a panel of microsatellite markers to characterise the genetic structure of two barrel sponge species, Xestospongia testudinaria and a currently undescribed Xestospongia species. We sampled across seven populations in the Wakatobi Marine National Park, SE Sulawesi (Indonesia) spanning a spatial scale of approximately 2 to 70 km, and present the first estimates of demographic connectivity for coral reef sponges. Genetic analyses showed high levels of genetic differentiation between all populations for both species, but contrasting patterns of genetic structuring for the two species. Autocorrelation analyses showed the likely dispersal distances of both species to be in the order of 60 and 140 m for Xestopongia sp. and Xestospongia testudinaria, respectively, which was supported by assignment tests that showed high levels of self-recruitment (>80%). We also found consistently high inbreeding coefficients across all populations for both species. Our study highlights the potential susceptibility of barrel sponges to environmental perturbations because they are generally long-lived, slow growing, have small population sizes and are likely to be reliant on self-recruitment. Surprisingly, despite these features we actually found the highest abundance of both barrel sponge species (although they were generally smaller) at a site that has been severely impacted by humans over the last fifty years. This suggests that barrel sponges exhibit environmental adaptation to declining environmental quality and has important implications for the management and conservation of these

  12. Resilience to disturbance despite limited dispersal and self-recruitment in tropical barrel sponges: implications for conservation and management.

    Directory of Open Access Journals (Sweden)

    James J Bell

    Full Text Available While estimates of connectivity are important for effective management, few such estimates are available for reef invertebrates other than for corals. Barrel sponges are one of the largest and most conspicuous members of the coral reef fauna across the Indo-Pacific and given their large size, longevity and ability to process large volumes of water, they have a major role in reef functioning. Here we used a panel of microsatellite markers to characterise the genetic structure of two barrel sponge species, Xestospongia testudinaria and a currently undescribed Xestospongia species. We sampled across seven populations in the Wakatobi Marine National Park, SE Sulawesi (Indonesia spanning a spatial scale of approximately 2 to 70 km, and present the first estimates of demographic connectivity for coral reef sponges. Genetic analyses showed high levels of genetic differentiation between all populations for both species, but contrasting patterns of genetic structuring for the two species. Autocorrelation analyses showed the likely dispersal distances of both species to be in the order of 60 and 140 m for Xestopongia sp. and Xestospongia testudinaria, respectively, which was supported by assignment tests that showed high levels of self-recruitment (>80%. We also found consistently high inbreeding coefficients across all populations for both species. Our study highlights the potential susceptibility of barrel sponges to environmental perturbations because they are generally long-lived, slow growing, have small population sizes and are likely to be reliant on self-recruitment. Surprisingly, despite these features we actually found the highest abundance of both barrel sponge species (although they were generally smaller at a site that has been severely impacted by humans over the last fifty years. This suggests that barrel sponges exhibit environmental adaptation to declining environmental quality and has important implications for the management and

  13. Precise mapping of the magnetic field in the CMS barrel yoke using cosmic rays

    Energy Technology Data Exchange (ETDEWEB)

    Chatrchyan, S. [Yerevan Physics Institute (Aremenia); et al.,

    2010-03-01

    The CMS detector is designed around a large 4 T superconducting solenoid, enclosed in a 12000-tonne steel return yoke. A detailed map of the magnetic field is required for the accurate simulation and reconstruction of physics events in the CMS detector, not only in the inner tracking region inside the solenoid but also in the large and complex structure of the steel yoke, which is instrumented with muon chambers. Using a large sample of cosmic muon events collected by CMS in 2008, the field in the steel of the barrel yoke has been determined with a precision of 3 to 8% depending on the location.

  14. Precise Mapping of the Magnetic Field in the CMS Barrel Yoke using Cosmic Rays

    CERN Document Server

    Chatrchyan, S; Sirunyan, A M; Adam, W; Arnold, B; Bergauer, H; Bergauer, T; Dragicevic, M; Eichberger, M; Erö, J; Friedl, M; Frühwirth, R; Ghete, V M; Hammer, J; Hänsel, S; Hoch, M; Hörmann, N; Hrubec, J; Jeitler, M; Kasieczka, G; Kastner, K; Krammer, M; Liko, D; Magrans de Abril, I; Mikulec, I; Mittermayr, F; Neuherz, B; Oberegger, M; Padrta, M; Pernicka, M; Rohringer, H; Schmid, S; Schöfbeck, R; Schreiner, T; Stark, R; Steininger, H; Strauss, J; Taurok, A; Teischinger, F; Themel, T; Uhl, D; Wagner, P; Waltenberger, W; Walzel, G; Widl, E; Wulz, C E; Chekhovsky, V; Dvornikov, O; Emeliantchik, I; Litomin, A; Makarenko, V; Marfin, I; Mossolov, V; Shumeiko, N; Solin, A; Stefanovitch, R; Suarez Gonzalez, J; Tikhonov, A; Fedorov, A; Karneyeu, A; Korzhik, M; Panov, V; Zuyeuski, R; Kuchinsky, P; Beaumont, W; Benucci, L; Cardaci, M; De Wolf, E A; Delmeire, E; Druzhkin, D; Hashemi, M; Janssen, X; Maes, T; Mucibello, L; Ochesanu, S; Rougny, R; Selvaggi, M; Van Haevermaet, H; Van Mechelen, P; Van Remortel, N; Adler, V; Beauceron, S; Blyweert, S; D'Hondt, J; De Weirdt, S; Devroede, O; Heyninck, J; Kalogeropoulos, A; Maes, J; Maes, M; Mozer, M U; Tavernier, S; Van Doninck, W; Van Mulders, P; Villella, I; Bouhali, O; Chabert, E C; Charaf, O; Clerbaux, B; De Lentdecker, G; Dero, V; Elgammal, S; Gay, A P R; Hammad, G H; Marage, P E; Rugovac, S; Vander Velde, C; Vanlaer, P; Wickens, J; Grunewald, M; Klein, B; Marinov, A; Ryckbosch, D; Thyssen, F; Tytgat, M; Vanelderen, L; Verwilligen, P; Basegmez, S; Bruno, G; Caudron, J; Delaere, C; Demin, P; Favart, D; Giammanco, A; Grégoire, G; Lemaitre, V; Militaru, O; Ovyn, S; Piotrzkowski, K; Quertenmont, L; Schul, N; Beliy, N; Daubie, E; Alves, G A; Pol, M E; Souza, M H G; Carvalho, W; De Jesus Damiao, D; De Oliveira Martins, C; Fonseca De Souza, S; Mundim, L; Oguri, V; Santoro, A; Silva Do Amaral, S M; Sznajder, A; Fernandez Perez Tomei, T R; Ferreira Dias, M A; Gregores, E M; Novaes, S F; Abadjiev, K; Anguelov, T; Damgov, J; Darmenov, N; Dimitrov, L; Genchev, V; Iaydjiev, P; Piperov, S; Stoykova, S; Sultanov, G; Trayanov, R; Vankov, I; Dimitrov, A; Dyulendarova, M; Kozhuharov, V; Litov, L; Marinova, E; Mateev, M; Pavlov, B; Petkov, P; Toteva, Z; Chen, G M; Chen, H S; Guan, W; Jiang, C H; Liang, D; Liu, B; Meng, X; Tao, J; Wang, J; Wang, Z; Xue, Z; Zhang, Z; Ban, Y; Cai, J; Ge, Y; Guo, S; Hu, Z; Mao, Y; Qian, S J; Teng, H; Zhu, B; Avila, C; Baquero Ruiz, M; Carrillo Montoya, C A; Gomez, A; Gomez Moreno, B; Ocampo Rios, A A; Osorio Oliveros, A F; Reyes Romero, D; Sanabria, J C; Godinovic, N; Lelas, K; Plestina, R; Polic, D; Puljak, I; Antunovic, Z; Dzelalija, M; Brigljevic, V; Duric, S; Kadija, K; Morovic, S; Fereos, R; Galanti, M; Mousa, J; Papadakis, A; Ptochos, F; Razis, P A; Tsiakkouri, D; Zinonos, Z; Hektor, A; Kadastik, M; Kannike, K; Müntel, M; Raidal, M; Rebane, L; Anttila, E; Czellar, S; Härkönen, J; Heikkinen, A; Karimäki, V; Kinnunen, R; Klem, J; Kortelainen, M J; Lampén, T; Lassila-Perini, K; Lehti, S; Lindén, T; Luukka, P; Mäenpää, T; Nysten, J; Tuominen, E; Tuominiemi, J; Ungaro, D; Wendland, L; Banzuzi, K; Korpela, A; Tuuva, T; Nedelec, P; Sillou, D; Besancon, M; Chipaux, R; Dejardin, M; Denegri, D; Descamps, J; Fabbro, B; Faure, J L; Ferri, F; Ganjour, S; Gentit, F X; Givernaud, A; Gras, P; Hamel de Monchenault, G; Jarry, P; Lemaire, M C; Locci, E; Malcles, J; Marionneau, M; Millischer, L; Rander, J; Rosowsky, A; Rousseau, D; Titov, M; Verrecchia, P; Baffioni, S; Bianchini, L; Bluj, M; Busson, P; Charlot, C; Dobrzynski, L; Granier de Cassagnac, R; Haguenauer, M; Miné, P; Paganini, P; Sirois, Y; Thiebaux, C; Zabi, A; Agram, J L; Besson, A; Bloch, D; Bodin, D; Brom, J M; Conte, E; Drouhin, F; Fontaine, J C; Gelé, D; Goerlach, U; Gross, L; Juillot, P; Le Bihan, A C; Patois, Y; Speck, J; Van Hove, P; Baty, C; Bedjidian, M; Blaha, J; Boudoul, G; Brun, H; Chanon, N; Chierici, R; Contardo, D; Depasse, P; Dupasquier, T; El Mamouni, H; Fassi, F; Fay, J; Gascon, S; Ille, B; Kurca, T; Le Grand, T; Lethuillier, M; Lumb, N; Mirabito, L; Perries, S; Vander Donckt, M; Verdier, P; Djaoshvili, N; Roinishvili, N; Roinishvili, V; Amaglobeli, N; Adolphi, R; Anagnostou, G; Brauer, R; Braunschweig, W; Edelhoff, M; Esser, H; Feld, L; Karpinski, W; Khomich, A; Klein, K; Mohr, N; Ostaptchouk, A; Pandoulas, D; Pierschel, G; Raupach, F; Schael, S; Schultz von Dratzig, A; Schwering, G; Sprenger, D; Thomas, M; Weber, M; Wittmer, B; Wlochal, M; Actis, O; Altenhöfer, G; Bender, W; Biallass, P; Erdmann, M; Fetchenhauer, G; Frangenheim, J; Hebbeker, T; Hilgers, G; Hinzmann, A; Hoepfner, K; Hof, C; Kirsch, M; Klimkovich, T; Kreuzer, P; Lanske, D; Merschmeyer, M; Meyer, A; Philipps, B; Pieta, H; Reithler, H; Schmitz, S A; Sonnenschein, L; Sowa, M; Steggemann, J; Szczesny, H; Teyssier, D; Zeidler, C; Bontenackels, M; Davids, M; Duda, M; Flügge, G; Geenen, H; Giffels, M; Haj Ahmad, W; Hermanns, T; Heydhausen, D; Kalinin, S; Kress, T; Linn, A; Nowack, A; Perchalla, L; Poettgens, M; Pooth, O; Sauerland, P; Stahl, A; Tornier, D; Zoeller, M H; Aldaya Martin, M; Behrens, U; Borras, K; Campbell, A; Castro, E; Dammann, D; Eckerlin, G; Flossdorf, A; Flucke, G; Geiser, A; Hatton, D; Hauk, J; Jung, H; Kasemann, M; Katkov, I; Kleinwort, C; Kluge, H; Knutsson, A; Kuznetsova, E; Lange, W; Lohmann, W; Mankel, R; Marienfeld, M; Meyer, A B; Miglioranzi, S; Mnich, J; Ohlerich, M; Olzem, J; Parenti, A; Rosemann, C; Schmidt, R; Schoerner-Sadenius, T; Volyanskyy, D; Wissing, C; Zeuner, W D; Autermann, C; Bechtel, F; Draeger, J; Eckstein, D; Gebbert, U; Kaschube, K; Kaussen, G; Klanner, R; Mura, B; Naumann-Emme, S; Nowak, F; Pein, U; Sander, C; Schleper, P; Schum, T; Stadie, H; Steinbrück, G; Thomsen, J; Wolf, R; Bauer, J; Blüm, P; Buege, V; Cakir, A; Chwalek, T; De Boer, W; Dierlamm, A; Dirkes, G; Feindt, M; Felzmann, U; Frey, M; Furgeri, A; Gruschke, J; Hackstein, C; Hartmann, F; Heier, S; Heinrich, M; Held, H; Hirschbuehl, D; Hoffmann, K H; Honc, S; Jung, C; Kuhr, T; Liamsuwan, T; Martschei, D; Mueller, S; Müller, Th; Neuland, M B; Niegel, M; Oberst, O; Oehler, A; Ott, J; Peiffer, T; Piparo, D; Quast, G; Rabbertz, K; Ratnikov, F; Ratnikova, N; Renz, M; Saout, C; Sartisohn, G; Scheurer, A; Schieferdecker, P; Schilling, F P; Schott, G; Simonis, H J; Stober, F M; Sturm, P; Troendle, D; Trunov, A; Wagner, W; Wagner-Kuhr, J; Zeise, M; Zhukov, V; Ziebarth, E B; Daskalakis, G; Geralis, T; Karafasoulis, K; Kyriakis, A; Loukas, D; Markou, A; Markou, C; Mavrommatis, C; Petrakou, E; Zachariadou, A; Gouskos, L; Katsas, P; Panagiotou, A; Evangelou, I; Kokkas, P; Manthos, N; Papadopoulos, I; Patras, V; Triantis, F A; Bencze, G; Boldizsar, L; Debreczeni, G; Hajdu, C; Hernath, S; Hidas, P; Horvath, D; Krajczar, K; Laszlo, A; Patay, G; Sikler, F; Toth, N; Vesztergombi, G; Beni, N; Christian, G; Imrek, J; Molnar, J; Novak, D; Palinkas, J; Szekely, G; Szillasi, Z; Tokesi, K; Veszpremi, V; Kapusi, A; Marian, G; Raics, P; Szabo, Z; Trocsanyi, Z L; Ujvari, B; Zilizi, G; Bansal, S; Bawa, H S; Beri, S B; Bhatnagar, V; Jindal, M; Kaur, M; 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Yang, Y; Zhang, L; Zhu, K; Zhu, R Y; Akgun, B; Carroll, R; Ferguson, T; Jang, D W; Jun, S Y; Paulini, M; Russ, J; Terentyev, N; Vogel, H; Vorobiev, I; Cumalat, J P; Dinardo, M E; Drell, B R; Ford, W T; Heyburn, B; Luiggi Lopez, E; Nauenberg, U; Stenson, K; Ulmer, K; Wagner, S R; Zang, S L; Agostino, L; Alexander, J; Blekman, F; Cassel, D; Chatterjee, A; Das, S; Gibbons, L K; Heltsley, B; Hopkins, W; Khukhunaishvili, A; Kreis, B; Kuznetsov, V; Patterson, J R; Puigh, D; Ryd, A; Shi, X; Stroiney, S; Sun, W; Teo, W D; Thom, J; Vaughan, J; Weng, Y; Wittich, P; Beetz, C P; Cirino, G; Sanzeni, C; Winn, D; Abdullin, S; Afaq, M A; Albrow, M; Ananthan, B; Apollinari, G; Atac, M; Badgett, W; Bagby, L; Bakken, J A; Baldin, B; Banerjee, S; Banicz, K; Bauerdick, L A T; Beretvas, A; Berryhill, J; Bhat, P C; Biery, K; Binkley, M; Bloch, I; Borcherding, F; Brett, A M; Burkett, K; Butler, J N; Chetluru, V; Cheung, H W K; Chlebana, F; Churin, I; Cihangir, S; Crawford, M; Dagenhart, W; Demarteau, M; Derylo, G; Dykstra, D; Eartly, D P; Elias, J E; Elvira, V D; Evans, D; Feng, L; Fischler, M; Fisk, I; Foulkes, S; Freeman, J; Gartung, P; Gottschalk, E; Grassi, T; Green, D; Guo, Y; Gutsche, O; Hahn, A; Hanlon, J; Harris, R M; Holzman, B; Howell, J; Hufnagel, D; James, E; Jensen, H; Johnson, M; Jones, C D; Joshi, U; Juska, E; Kaiser, J; Klima, B; Kossiakov, S; Kousouris, K; Kwan, S; Lei, C M; Limon, P; Lopez Perez, J A; Los, S; Lueking, L; Lukhanin, G; Lusin, S; Lykken, J; Maeshima, K; Marraffino, J M; Mason, D; McBride, P; Miao, T; Mishra, K; Moccia, S; Mommsen, R; Mrenna, S; Muhammad, A S; Newman-Holmes, C; Noeding, C; O'Dell, V; Prokofyev, O; Rivera, R; Rivetta, C H; Ronzhin, A; Rossman, P; Ryu, S; Sekhri, V; Sexton-Kennedy, E; Sfiligoi, I; Sharma, S; Shaw, T M; Shpakov, D; Skup, E; Smith, R P; Soha, A; Spalding, W J; Spiegel, L; Suzuki, I; Tan, P; Tanenbaum, W; Tkaczyk, S; Trentadue, R; Uplegger, L; Vaandering, E W; Vidal, R; Whitmore, J; Wicklund, E; Wu, W; Yarba, J; Yumiceva, F; Yun, J C; Acosta, D; Avery, P; Barashko, V; Bourilkov, D; Chen, M; Di Giovanni, G P; Dobur, D; Drozdetskiy, A; Field, R D; Fu, Y; Furic, I K; Gartner, J; Holmes, D; Kim, B; Klimenko, S; Konigsberg, J; Korytov, A; Kotov, K; Kropivnitskaya, A; Kypreos, T; Madorsky, A; Matchev, K; Mitselmakher, G; Pakhotin, Y; Piedra Gomez, J; Prescott, C; Rapsevicius, V; Remington, R; Schmitt, M; Scurlock, B; Wang, D; Yelton, J; Ceron, C; Gaultney, V; Kramer, L; Lebolo, L M; Linn, S; Markowitz, P; Martinez, G; Rodriguez, J L; Adams, T; Askew, A; Baer, H; Bertoldi, M; Chen, J; Dharmaratna, W G D; Gleyzer, S V; Haas, J; Hagopian, S; Hagopian, V; Jenkins, M; Johnson, K F; Prettner, E; Prosper, H; Sekmen, S; Baarmand, M M; Guragain, S; Hohlmann, M; Kalakhety, H; Mermerkaya, H; Ralich, R; Vodopiyanov, I; Abelev, B; Adams, M R; Anghel, I M; Apanasevich, L; Bazterra, V E; Betts, R R; Callner, J; Castro, M A; Cavanaugh, R; Dragoiu, C; Garcia-Solis, E J; Gerber, C E; Hofman, D J; Khalatian, S; Mironov, C; Shabalina, E; Smoron, A; Varelas, N; Akgun, U; Albayrak, E A; Ayan, A S; Bilki, B; Briggs, R; Cankocak, K; Chung, K; Clarida, W; Debbins, P; Duru, F; Ingram, F D; Lae, C K; McCliment, E; Merlo, J P; Mestvirishvili, A; Miller, M J; Moeller, A; Nachtman, J; Newsom, C R; Norbeck, E; Olson, J; Onel, Y; Ozok, F; Parsons, J; Schmidt, I; Sen, S; Wetzel, J; Yetkin, T; Yi, K; Barnett, B A; Blumenfeld, B; Bonato, A; Chien, C Y; Fehling, D; Giurgiu, G; Gritsan, A V; Guo, Z J; Maksimovic, P; Rappoccio, S; Swartz, M; Tran, N V; Zhang, Y; Baringer, P; Bean, A; Grachov, O; Murray, M; Radicci, V; Sanders, S; Wood, J S; Zhukova, V; Bandurin, D; Bolton, T; Kaadze, K; Liu, A; Maravin, Y; Onoprienko, D; Svintradze, I; Wan, Z; Gronberg, J; Hollar, J; Lange, D; Wright, D; Baden, D; Bard, R; Boutemeur, M; Eno, S C; Ferencek, D; Hadley, N J; Kellogg, R G; Kirn, M; Kunori, S; Rossato, K; Rumerio, P; Santanastasio, F; Skuja, A; Temple, J; Tonjes, M B; Tonwar, S C; Toole, T; Twedt, E; Alver, B; Bauer, G; Bendavid, J; Busza, W; Butz, E; Cali, I A; Chan, M; D'Enterria, D; Everaerts, P; Gomez Ceballos, G; Hahn, K A; Harris, P; Jaditz, S; Kim, Y; Klute, M; Lee, Y J; Li, W; Loizides, C; Ma, T; Miller, M; Nahn, S; Paus, C; Roland, C; Roland, G; Rudolph, M; Stephans, G; Sumorok, K; Sung, K; Vaurynovich, S; Wenger, E A; Wyslouch, B; Xie, S; Yilmaz, Y; Yoon, A S; Bailleux, D; Cooper, S I; Cushman, P; Dahmes, B; De Benedetti, A; Dolgopolov, A; Dudero, P R; Egeland, R; Franzoni, G; Haupt, J; Inyakin, A; Klapoetke, K; Kubota, Y; Mans, J; Mirman, N; Petyt, D; Rekovic, V; Rusack, R; Schroeder, M; Singovsky, A; Zhang, J; Cremaldi, L M; Godang, R; Kroeger, R; Perera, L; Rahmat, R; Sanders, D A; Sonnek, P; Summers, D; Bloom, K; Bockelman, B; Bose, S; Butt, J; Claes, D R; Dominguez, A; Eads, M; Keller, J; Kelly, T; Kravchenko, I; Lazo-Flores, J; Lundstedt, C; Malbouisson, H; Malik, S; Snow, G R; Baur, U; Iashvili, I; Kharchilava, A; Kumar, A; Smith, K; Strang, M; Alverson, G; Barberis, E; Boeriu, O; Eulisse, G; Govi, G; McCauley, T; Musienko, Y; Muzaffar, S; Osborne, I; Paul, T; Reucroft, S; Swain, J; Taylor, L; Tuura, L; Anastassov, A; Gobbi, B; Kubik, A; Ofierzynski, R A; Pozdnyakov, A; Schmitt, M; Stoynev, S; Velasco, M; Won, S; Antonelli, L; Berry, D; Hildreth, M; Jessop, C; Karmgard, D J; Kolberg, T; Lannon, K; Lynch, S; Marinelli, N; Morse, D M; Ruchti, R; Slaunwhite, J; Warchol, J; Wayne, M; Bylsma, B; Durkin, L S; Gilmore, J; Gu, J; Killewald, P; Ling, T Y; Williams, G; Adam, N; Berry, E; Elmer, P; Garmash, A; Gerbaudo, D; Halyo, V; Hunt, A; Jones, J; Laird, E; Marlow, D; Medvedeva, T; Mooney, M; Olsen, J; Piroué, P; Stickland, D; Tully, C; Werner, J S; Wildish, T; Xie, Z; Zuranski, A; Acosta, J G; Bonnett Del Alamo, M; Huang, X T; Lopez, A; Mendez, H; Oliveros, S; Ramirez Vargas, J E; Santacruz, N; Zatzerklyany, A; Alagoz, E; Antillon, E; Barnes, V E; Bolla, G; Bortoletto, D; Everett, A; Garfinkel, A F; Gecse, Z; Gutay, L; Ippolito, N; Jones, M; Koybasi, O; Laasanen, A T; Leonardo, N; Liu, C; Maroussov, V; Merkel, P; Miller, D H; Neumeister, N; Sedov, A; Shipsey, I; Yoo, H D; Zheng, Y; Jindal, P; Parashar, N; Cuplov, V; Ecklund, K M; Geurts, F J M; Liu, J H; Maronde, D; Matveev, M; Padley, B P; Redjimi, R; Roberts, J; Sabbatini, L; Tumanov, A; Betchart, B; Bodek, A; Budd, H; Chung, Y S; de Barbaro, P; Demina, R; Flacher, H; Gotra, Y; Harel, A; Korjenevski, S; Miner, D C; Orbaker, D; Petrillo, G; Vishnevskiy, D; Zielinski, M; Bhatti, A; Demortier, L; Goulianos, K; Hatakeyama, K; Lungu, G; Mesropian, C; Yan, M; Atramentov, O; Bartz, E; Gershtein, Y; Halkiadakis, E; Hits, D; Lath, A; Rose, K; Schnetzer, S; Somalwar, S; Stone, R; Thomas, S; Watts, T L; Cerizza, G; Hollingsworth, M; Spanier, S; Yang, Z C; York, A; Asaadi, J; Aurisano, A; Eusebi, R; Golyash, A; Gurrola, A; Kamon, T; Nguyen, C N; Pivarski, J; Safonov, A; Sengupta, S; Toback, D; Weinberger, M; Akchurin, N; Berntzon, L; Gumus, K; Jeong, C; Kim, H; Lee, S W; Popescu, S; Roh, Y; Sill, A; Volobouev, I; Washington, E; Wigmans, R; Yazgan, E; Engh, D; Florez, C; Johns, W; Pathak, S; Sheldon, P; Andelin, D; Arenton, M W; Balazs, M; Boutle, S; Buehler, M; Conetti, S; Cox, B; Hirosky, R; Ledovskoy, A; Neu, C; Phillips II, D; Ronquest, M; Yohay, R; Gollapinni, S; Gunthoti, K; Harr, R; Karchin, P E; Mattson, M; Sakharov, A; Anderson, M; Bachtis, M; Bellinger, J N; Carlsmith, D; Crotty, I; Dasu, S; Dutta, S; Efron, J; Feyzi, F; Flood, K; Gray, L; Grogg, K S; Grothe, M; Hall-Wilton, R; Jaworski, M; Klabbers, P; Klukas, J; Lanaro, A; Lazaridis, C; Leonard, J; Loveless, R; Magrans de Abril, M; Mohapatra, A; Ott, G; Polese, G; Reeder, D; Savin, A; Smith, W H; Sourkov, A; Swanson, J; Weinberg, M; Wenman, D; Wensveen, M; White, A

    2010-01-01

    The CMS detector is designed around a large 4 T superconducting solenoid, enclosed in a 12000-tonne steel return yoke. A detailed map of the magnetic field is required for the accurate simulation and reconstruction of physics events in the CMS detector, not only in the inner tracking region inside the solenoid but also in the large and complex structure of the steel yoke, which is instrumented with muon chambers. Using a large sample of cosmic muon events collected by CMS in 2008, the field in the steel of the barrel yoke has been determined with a precision of 3 to 8% depending on the location.

  15. 2D fluid flow in the downcomer and dynamic response of the core barrel during PWR blowdown

    International Nuclear Information System (INIS)

    Katz, F.; Krieg, R.; Ludwig, A.; Schlechtendahl, E.G.; Stoelting, K.

    1977-01-01

    As a part of the HDR program, methods for coupled fluid/structure dynamics are being developed. On the fluid side the 2D finite difference code YAQUI has been modified and adapted to describe the fluid dynamics in the downcomer of PWR's. On the structural side for determination of the dynamic core barrel response the code CYLDY2 has been developed. In this code the core barrel is treated as a thin cylindrical shell fixed at the upper end and ring stiffened at the lower end. The mass of the lower end ring also simulates a part of the core mass. Both models have been successfully tested. Coupling has been achieved for a simplified structural model proving the correctness of the coupling procedure. YAQUIR is a significantly modified version of the code YAQUI. The coupling of YAQUIR and CYLDY2 is performed by imbedding the structural model in the fluid model. Fluid velocities are parellel to the fluid/structure interface. The structure displacements define the time and space dependent thickness of the two-dimensional fluid layer. While coupling of the complete CYLDY2 model with YAQUIR is still underway, results have been obtained with a simple axisymmetric structural model. For an axisymmetric test case three forms of pressure fluctuations have been observed: 1) radial oscillations dominated by the local compressibility of the water, 2) axial compression/expansion waves in the water considerably different from those obtained for a rigid barrel, 3) bulk axial water oscillations dominated by the global compressibility of the core barrel. (Auth.)

  16. Geometry-invariant gradient refractive index lens: analytical ray tracing.

    Science.gov (United States)

    Bahrami, Mehdi; Goncharov, Alexander V

    2012-05-01

    A new class of gradient refractive index (GRIN) lens is introduced and analyzed. The interior iso-indicial contours mimic the external shape of the lens, which leads to an invariant geometry of the GRIN structure. The lens model employs a conventional surface representation using a coincoid of revolution with a higher-order aspheric term. This model has a unique feature, namely, it allows analytical paraxial ray tracing. The height and the angle of an arbitrary incident ray can be found inside the lens in a closed-form expression, which is used to calculate the main optical characteristics of the lens, including the optical power and third-order monochromatic aberration coefficients. Moreover, due to strong coupling of the external surface shape to the GRIN structure, the proposed GRIN lens is well suited for studying accommodation mechanism in the eye. To show the power of the model, several examples are given emphasizing the usefulness of the analytical solution. The presented geometry-invariant GRIN lens can be used for modeling and reconstructing the crystalline lens of the human eye and other types of eyes featuring a GRIN lens.

  17. Evaluating WAIS-IV structure through a different psychometric lens: structural causal model discovery as an alternative to confirmatory factor analysis.

    Science.gov (United States)

    van Dijk, Marjolein J A M; Claassen, Tom; Suwartono, Christiany; van der Veld, William M; van der Heijden, Paul T; Hendriks, Marc P H

    Since the publication of the WAIS-IV in the U.S. in 2008, efforts have been made to explore the structural validity by applying factor analysis to various samples. This study aims to achieve a more fine-grained understanding of the structure of the Dutch language version of the WAIS-IV (WAIS-IV-NL) by applying an alternative analysis based on causal modeling in addition to confirmatory factor analysis (CFA). The Bayesian Constraint-based Causal Discovery (BCCD) algorithm learns underlying network structures directly from data and assesses more complex structures than is possible with factor analysis. WAIS-IV-NL profiles of two clinical samples of 202 patients (i.e. patients with temporal lobe epilepsy and a mixed psychiatric outpatient group) were analyzed and contrasted with a matched control group (N = 202) selected from the Dutch standardization sample of the WAIS-IV-NL to investigate internal structure by means of CFA and BCCD. With CFA, the four-factor structure as proposed by Wechsler demonstrates acceptable fit in all three subsamples. However, BCCD revealed three consistent clusters (verbal comprehension, visual processing, and processing speed) in all three subsamples. The combination of Arithmetic and Digit Span as a coherent working memory factor could not be verified, and Matrix Reasoning appeared to be isolated. With BCCD, some discrepancies from the proposed four-factor structure are exemplified. Furthermore, these results fit CHC theory of intelligence more clearly. Consistent clustering patterns indicate these results are robust. The structural causal discovery approach may be helpful in better interpreting existing tests, the development of new tests, and aid in diagnostic instruments.

  18. Barrel silicon vertex tracker for PHENIX at RHIC

    International Nuclear Information System (INIS)

    Ohnishi, Hiroaki

    2005-01-01

    The barrel silicon vertex tracker has been proposed as an upgrade project of the PHENIX experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. The prime motivation for this new detector is to provide precision measurements of heavy-quark production (charm and beauty) in A + A, p(d) + A, and polarized p + p collisions. The current design of the silicon vertex tracker comprises a four-layer barrel detector, built from two internal layers of pixel detectors and two external layers of projective 'stripixels' which complement the central spectrometer arms of PHENIX. In this paper, the physics motivation of the silicon vertex tracker upgrade and the concept of the new detector will be discussed. Moreover, the status of the new development and beginning production of the silicon detectors will be presented

  19. Simulgeo and its application for the muon barrel position monitor

    International Nuclear Information System (INIS)

    Brunel, L.

    1999-01-01

    The design process of the Muon Barrel Position Monitor of the CMS (compact muon solenoid) experiment for LHC is at the origin of the need of a software like Simulgeo. The software Silmugeo started to be developed in 1995 in order to allow the study of many systems. The idea of Simulgeo is to automatically make the modelling of a system and automatically construct the design matrix. This paper makes in part 2 an overview of the possibilities of Simulgeo, in part 3 it presents the standard objects. In part 4, it explains the mathematical basis and in part 5 the computing aspect. In part 6, it shows an application to the Muon Barrel Position Monitor Project and, in part 7, it mentions other projects where it has been used

  20. The bar PANDA Barrel-TOF Detector at FAIR

    Science.gov (United States)

    Zimmermann, S.; Suzuki, K.; Steinschaden, D.; Chirita, M.; Ahmed, G.; Dutta, K.; Kalita, K.; Lehmann, A.; Böhm, M.; Schwarz, K.; Orth, H.; Brinkmann, K.-Th.

    2017-08-01

    The barrel-Time-of-Flight subdetector is one of the outer layers of the multi-layer design of the \\panda target spectrometer. It is designed with a minimal material budget in mind mainly consisting of 90×30×5 mm3 thin plastic scintillator tiles read out on each end by a serial connection of 4 SiPMs. 120 such tiles are placed on 16 2460 × 180 mm2 PCB boards forming a barrel covering an azimuthal angle from 22.5o to 150o. The detector is designed to achieve a time resolution below σ< 100 ps which allows to distinguish events in the constant stream of hits, as well as particle identification below the Cherenkov threshold via the time-of-flight; simultaneously providing the interaction times of events. The current prototype achieved a time resolution of ~54 ps, well below the design goal.

  1. Design of the LHC US ATLAS Barrel Cryostat

    CERN Document Server

    Rehak, M L; Farah, Y; Grandinetti, R; Müller, T; Norton, S; Sondericker, J

    2002-01-01

    One of the experiments of CERN's Large Hadron Collider (LHC) is the ATLAS Liquid Argon detector. The Liquid Argon Barrel Cryostat is part of the United States contribution to the LHC project and its design is presented here. The device is made up of four concentric cylinders: the smallest and largest of which form a vacuum vessel enclosing a cold vessel cryostat filled with liquid argon. The Cryostat serves as the housing for an electromagnetic barrel calorimeter, supports and provides space in vacuum for a solenoid magnet while the toroidal opening furnishes room for a tracker detector. Design requirements are determined by its use in a collider experiment: the construction has to be compact, the material between the interaction region and the calorimeter has to be minimal and made of aluminum to reduce the amount of absorbing material. The design complies with code regulations while being optimized for its use in a physics environment. (2 refs).

  2. ATLAS barrel toroid integration and test area in building 180

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two 'double-pancake' windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. The barrel toroid is being assembled in building 180 on the Meyrin site. In the first phase of assembly, the coils are packed into their aluminium-alloy casing. These photos show the double-pancake coils from ANSALDO and the coil casings from ALSTOM. In the foreground is the tooling from COSMI used to turn over the coil casings during this first phase. In the right background is the yellow lifting gantry manufactured at JINR-Dubna, Russia which will transport the coil casings to a heating table for prestressing. Two test benches with magnetic mirror are also visible.

  3. Design of LED projector based on gradient-index lens

    Science.gov (United States)

    Qian, Liyong; Zhu, Xiangbing; Cui, Haitian; Wang, Yuanhang

    2018-01-01

    In this study, a new type of projector light path is designed to eliminate the deficits of existing projection systems, such as complex structure and low collection efficiency. Using a three-color LED array as the lighting source, by means of the special optical properties of a gradient-index lens, the complex structure of the traditional projector is simplified. Traditional components, such as the color wheel, relay lens, and mirror, become unnecessary. In this way, traditional problems, such as low utilization of light energy and loss of light energy, are solved. With the help of Zemax software, the projection lens is optimized. The optimized projection lens, LED, gradient-index lens, and digital micromirror device are imported into Tracepro. The ray tracing results show that both the utilization of light energy and the uniformity are improved significantly.

  4. A catoptric lens

    International Nuclear Information System (INIS)

    Rambauske, W.R.

    1973-01-01

    The invention relates to a catoptric lens for combining energies transmitted by several sources such as lasers; said lens comprising mirrors, the reflective surfaces of which have their focuses spaced from a common axis of symmetry. By means of these reflecting surfaces, which are generated by the nutation of portions of quadratic conics about the axis of symmetry, it is possible to focus the energy emmited by several lasers at the focus of the exit-mirror reflecting surface. This can be applied to thermonuclear fusion [fr

  5. Device for cementing radioactive of toxic waste into barrels

    International Nuclear Information System (INIS)

    Hempelmann, W.; Waldenmeier, G.; Mathis, P.; Mathis, B.; Mathis, F.

    1987-01-01

    The plant consists of conventional means, such as through mixers and dosing and transport spirals, which are accommodated in a glovebox. The inactive additives cement and sand and the active materials evaporation concentrates and sludges are mixed by them, and are then filled into a waste barrel which is empty or already filled with solid waste. Liquid radioactive wastes are used to concrete over the solid waste. (DG) [de

  6. Signal feedthroughs for the ATLAS barrel and endcap calorimeters

    Science.gov (United States)

    Axen, D.; Hackenburg, R.; Hoffmann, A.; Kane, S.; Lissauer, D.; Makowiecki, D.; Muller, T.; Pate, D.; Radeka, V.; Rahm, D.; Rehak, M.; Rescia, S.; Sexton, K.; Sondericker, J.; Birney, P.; Dowling, A. W.; Fincke-Keeler, M.; Hodges, T.; Holness, F.; Honkanen, N.; Keeler, R.; Langstaff, R.; Lenckowski, M.; Lefebvre, M.; Poffenberger, P.; Vowles, G.; Oram, C.

    2005-06-01

    The function, design, construction, testing, and installation of the signal feedthroughs for the barrel and endcap ATLAS liquid argon calorimeters are described. The feedthroughs provide a high density and radiation hard method to extract over 200 000 signals from the cryogenic environment of the calorimeters using an application of a design based on flexible kapton circuit board transmission lines. A model to describe the frequency dependent behavior of the transmission lines is also presented.

  7. Tridimensional measurements of the Barrel absorbers (Module 0)

    CERN Document Server

    Puzo, P

    2001-01-01

    In this note we describe the principle of the measurements done on the ATLAS absorbers that have been fabricated for the module 0 of the Liquid Argon Electromagnetic Barrel Calorimeter. We explain how the measurements are used to reconstruct the tridimensional geometry of each absorber. We show the results obtained for module 0. The same kind of measurements will be done for the series absorbers

  8. Non-compensation of the ATLAS barrel combined calorimeter prototype

    International Nuclear Information System (INIS)

    Kul'chitskij, Yu.A.; Kuz'min, M.V.

    1998-01-01

    The e / π ratio for the ATLAS Barrel Combined Calorimeter Prototype, composed from electromagnetic LArg calorimeter and hadronic Tile calorimeter was investigated. Response of Combined Calorimeter on pions and electrons in the energy region of 20-300 GeV was studied. Found e / h = 1.37 ± 0.01 ± 0.02 is in good agreement with the results from previous Combined Calorimeter tests but has more precisions

  9. Time calibration for barrel TOF system of BESIII

    International Nuclear Information System (INIS)

    Sun Shengsen

    2012-01-01

    The time calibration for barrel TOF system of BESIII is studied in this paper. The time resolution for single layer and double layer have been achieved about 97 ps and 78 ps for electrons in Bhabha events respectively. The pulse height correction using electronic scan curve and the predicted time calculated using Kalman filter method are introduced. This paper also describes the analysis of correlation of measured time.

  10. Background neutron in the endcap and barrel regions of resistive ...

    Indian Academy of Sciences (India)

    function of the neutron energy in the range of 0.01 eV–1 GeV have been simulated through. RPC set-up. In order to evaluate the response of detector in the LHC background envi- ronment, the neutron spectrum expected in the CMS muon endcap and barrel region were taken into account. A hit rate of about 165.5 Hz cm. −2.

  11. Double Barreled Wet Colostomy: Initial Experience and Literature Review

    OpenAIRE

    Luis Salgado-Cruz; Eloy Espin-Basany; Francesc Vallribera-Valls; Jose Sanchez-Garcia; Luis Miguel Jimenez-Gomez; Marc Marti-Gallostra; Ana Garza-Maldonado

    2014-01-01

    Background. Pelvic exenteration and multivisceral resection in colorectal have been described as a curative and palliative intervention. Urinary tract reconstruction in a pelvic exenteration is achieved in most cases with an ileal conduit of Bricker, although different urinary reservoirs have been described. Methods. A retrospective and observational study of six patients who underwent a pelvic exenteration and urinary tract reconstruction with a double barreled wet colostomy (DBWC) was done,...

  12. The representation of social facial touch in rat barrel cortex.

    Science.gov (United States)

    Bobrov, Evgeny; Wolfe, Jason; Rao, Rajnish P; Brecht, Michael

    2014-01-06

    Controlled presentation of stimuli to anesthetized [1] or awake [2] animals suggested that neurons in sensory cortices respond to elementary features [3, 4], but we know little about neuronal responses evoked by social interactions. Here we investigate processing in the barrel cortex of rats engaging in social facial touch [5, 6]. Sensory stimulation by conspecifics differs from classic whisker stimuli such as deflections, contact poles [7, 8], or textures [9, 10]. A large fraction of barrel cortex neurons responded to facial touch. Social touch responses peaked when animals aligned their faces and contacted each other by multiple whiskers with small, irregular whisker movements. Object touch was associated with larger, more regular whisker movements, and object responses were weaker than social responses. Whisker trimming abolished responses. During social touch, neurons in males increased their firing on average by 44%, while neurons in females increased their firing by only 19%. In females, socially evoked and ongoing firing rates were more than 1.5-fold higher in nonestrus than in estrus. Barrel cortex represented socially different contacts by distinct firing rates, and the variation of activity with sex and sexual status could contribute to the generation of gender-specific neural constructs of conspecifics. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. A lazy way to design infrared lens

    Science.gov (United States)

    Qiu, RongSheng; Wu, JianDong; Chen, LongJiang; Yu, Kun; Pang, HaoJun; Hu, BaiZhen

    2017-08-01

    We designed a compact middle-wave infrared (MWIR) lens with a large focal length ratio (about 1.5:1), used in the 3.7 to 4.8 μm range. The lens is consisted of a compact front group and a re-imaging group. Thanks to the compact front group configuration, it is possible to install a filter wheel mechanism in such a tight space. The total track length of the lens is about 50mm, which includes a 2mm thick protective window and a cold shield of 12mm. The full field of view of the lens is about 3.6°, and F number is less than 1.6, the image circle is about 4.6mm in diameter. The design performance of the lens reaches diffraction limitation, and doesn't change a lot during a temperature range of -40°C +60°C. This essay proposed a stepwise design method of infrared optical system guided by the qualitative approach. The method fully utilize the powerful global optimization ability, with a little effort to write code snippet in optical design software, frees optical engineer from tedious calculation of the original structure.

  14. The barrel EM is cold and full

    CERN Multimedia

    Fournier, D

    After insertion of the two EM wheels in the cryostat in 2003, the cold vessel was finally closed in December (Omega seals and welds). This was then followed by the installation of the solenoid in February, and the closing of the warm vessel in March (see eNews of December 2003). During these few months the LAr cryogenic system was thoroughly tested, and its control system commissioned, each of the ~1000 control points at a time. Finally, in April the cool-down could start. Rather unusual for liquid argon detectors, the cool-down was made in its first part (above 140K) by circulating cold nitrogen gas (instead of liquid nitrogen) in the heat exchangers. The reason was to limit as much as possible temperature gradients in the calorimeter body. With the accordion structure, each of the EM wheel behaves as a single piece, which could be damaged if the supporting rings at its outside would contract faster than the active part inside. Also with improperly controlled gradients, the two wheels - 4 meters in diamete...

  15. CMS: the first barrel ring completed!

    CERN Multimedia

    2000-01-01

    Seven years after design studies began, CERN and the German company DWE have erected the first of the five CMS yoke rings, a giant component weighing 1200 tonnes. The first ring of the CMS magnet yoke, a twelve-sided 15-metre-high colossus, has been erected in the new hall at Point 5 near Cessy. For the last few days it has stood unaided, no longer relying on the central structure required for its assembly. Its construction marks an important milestone in the CMS programme, the culmination of seven years of work at CERN and over two years of manufacturing at DWE. Awarded the contract by the Swiss Federal Institute of Technology (ETH), Zürich, the German manufacturer has produced and assembled the ring components in collaboration with a team from CERN. This feat of mechanical engineering was celebrated two weeks ago at a drink attended by the main protagonists, headed by Franz Kufner, divisional manager at DWE, Franz Leher, production engineer at DWE, Alain Hervé, CMS technical coordinator,...

  16. Energy metrics for driving competitiveness of countries. Energy weakness magnitude, GDP per barrel and barrels per capita

    Energy Technology Data Exchange (ETDEWEB)

    Coccia, Mario [National Research Council of Italy, CERIS-CNR, Institute for Economic Research on Firm and Growth, Collegio Carlo Alberto - via Real Collegio, n. 30, 10024 Moncalieri (Torino) (Italy)

    2010-03-15

    Energy metrics is the development of a whole new theoretical framework for the conception and measurement of energy and economic system performances, energy efficiency and productivity improvements with important political economy implications consistent with the best use of all natural and economic resources. The purpose of this research is to present some vital energy indicators based on magnitude and scale of energy weakness, GDP per barrel of oil that is an indicator of energy productivity and barrels (of oil) per capita that is an indicator of energy efficiency. Energy metrics can support the monitoring of energy and economic system performances in order to design effective energy strategy and political economy interventions focused on the 'competitive advantage' increase of countries in modern economies. (author)

  17. Energy metrics for driving competitiveness of countries: Energy weakness magnitude, GDP per barrel and barrels per capita

    Energy Technology Data Exchange (ETDEWEB)

    Coccia, Mario, E-mail: m.coccia@ceris.cnr.i [National Research Council of Italy, CERIS-CNR, Institute for Economic Research on Firm and Growth, Collegio Carlo Alberto-via Real Collegio, n. 30, 10024 Moncalieri (Torino) (Italy)

    2010-03-15

    Energy metrics is the development of a whole new theoretical framework for the conception and measurement of energy and economic system performances, energy efficiency and productivity improvements with important political economy implications consistent with the best use of all natural and economic resources. The purpose of this research is to present some vital energy indicators based on magnitude and scale of energy weakness, GDP per barrel of oil that is an indicator of energy productivity and barrels (of oil) per capita that is an indicator of energy efficiency. Energy metrics can support the monitoring of energy and economic system performances in order to design effective energy strategy and political economy interventions focused on the 'competitive advantage' increase of countries in modern economies.

  18. Energy metrics for driving competitiveness of countries: Energy weakness magnitude, GDP per barrel and barrels per capita

    International Nuclear Information System (INIS)

    Coccia, Mario

    2010-01-01

    Energy metrics is the development of a whole new theoretical framework for the conception and measurement of energy and economic system performances, energy efficiency and productivity improvements with important political economy implications consistent with the best use of all natural and economic resources. The purpose of this research is to present some vital energy indicators based on magnitude and scale of energy weakness, GDP per barrel of oil that is an indicator of energy productivity and barrels (of oil) per capita that is an indicator of energy efficiency. Energy metrics can support the monitoring of energy and economic system performances in order to design effective energy strategy and political economy interventions focused on the 'competitive advantage' increase of countries in modern economies.

  19. Quadrupole magnetic lens

    International Nuclear Information System (INIS)

    Piskunov, V.A.

    1981-01-01

    The following connection of windings of electromagnet is suggested for simplification of the design of qUadrupole magnetic lens intended for use in radiotechnical and electron-optical devices. The mentioned windings are connected with each other by a bridge scheme and the variable resistors are switched in its diagonals in the lens containing four electromagnet with windings connected with two variable resistors the mobile contacts of which are connected with a direct current source. Current redistribution between left windings and right windings takes place at shift of mobile contact of variable resistor, and current redistribution between upper and low coils of electromagnets takes place at shifting mobile contact of the other variable resistor. In this case smooth and independent electron-optical misalignment of lens by two mutually perpendicular directions proceeds. Use of the given design of the lens in the oscillograph permits to use printing assembly for alignment plate and to reduce the number of connections at the expense of decreasing the number of resistors

  20. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... prescription. There is no such thing as a "one size fits all" contact lens. Lenses that are not properly fitted may scratch the eye or cause blood vessels to grow into the cornea. Even if you have perfect vision, you need to get an eye exam and a prescription ...

  1. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... Ophthalmologist Patient Stories Español Eye Health / News Halloween Hazard: The Hidden Dangers of Buying Decorative Contact Lenses ... One Use Facts About Colored Contacts and Halloween Safety Colored Contact Lens Facts Over-the-Counter Costume ...

  2. MISSING: BUBBLE CHAMBER LENS

    CERN Multimedia

    2001-01-01

    Would the person who borrowed the large bubble chamber lens from the Microcosm workshops on the ISR please return it. This is a much used piece from our object archives. If anybody has any information about the whereabouts of this object, please contact Emma.Sanders@cern.ch Thank you

  3. The Lens of Chemistry

    Science.gov (United States)

    Thalos, Mariam

    2013-01-01

    Chemistry possesses a distinctive theoretical lens--a distinctive set of theoretical concerns regarding the dynamics and transformations of a perplexing variety of organic and nonorganic substances--to which it must be faithful. Even if it is true that chemical facts bear a special (reductive) relationship to physical facts, nonetheless it will…

  4. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... wear any kind of contact lens. In Butler's case, the lenses caused an infection and left her with a corneal ... A recent article from U.S. News and World Report explains what ophthalmologists are and how they can ...

  5. bubble chamber lens

    CERN Multimedia

    Was used in a PS experiment. Before the days of electronic detectors, visual techniques were used to detect particles, using detectors such as spark chambers and bubble chambers. This plexiglass lens was used to focus the image of tracks so they could be photographed.

  6. Thermal Lens Microscope

    Science.gov (United States)

    Uchiyama, Kenji; Hibara, Akihide; Kimura, Hiroko; Sawada, Tsuguo; Kitamori, Takehiko

    2000-09-01

    We developed a novel laser microscope based on the thermal lens effect induced by a coaxial beam comprised of excitation and probe beams. The signal generation mechanism was confirmed to be an authentic thermal lens effect from the measurement of signal and phase dependences on optical configurations between the sample and the probe beam focus, and therefore, the thermal lens effect theory could be applied. Two-point spatial resolution was determined by the spot size of the excitation beam, not by the thermal diffusion length. Sensitivity was quite high, and the detection ability, evaluated using a submicron microparticle containing dye molecules, was 0.8 zmol/μm2, hence a distribution image of trace chemical species could be obtained quantitatively. In addition, analytes are not restricted to fluorescent species, therefore, the thermal lens microscope is a promising analytical microscope. A two-dimensional image of a histamine molecule distribution, which was produced in mast cells at the femtomole level in a human nasal mucous polyp, was obtained.

  7. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... an Ophthalmologist Patient Stories Español Eye Health / News Halloween Hazard: The Hidden Dangers of Buying Decorative Contact ... After One Use Facts About Colored Contacts and Halloween Safety Colored Contact Lens Facts Over-the-Counter ...

  8. The barrel muon spectrometer of the ATLAS detector has acquired its first cosmic event in a magnetic field produced by the barrel toroid magnet.

    CERN Multimedia

    2006-01-01

    A 3-D event display of a cosmic muon event, showing the path of a muon travelling through three layers of the barrel muon spectrometer. Three of the eight coils of the barrel toroid magnet can be seen in the top half of the drawing.

  9. Clinical survey of lens care in contact lens patients.

    Science.gov (United States)

    Ky, W; Scherick, K; Stenson, S

    1998-10-01

    Overall, contact lenses provide a safe and effective modality for vision correction. However, problems do occasionally arise. Up to 80% of contact lens complications can be traced to poor patient compliance with recommended lens care guidelines. We conducted a survey to evaluate the level of patient compliance in specific areas of lens care and maintenance and to assess patient knowledge of basic contact lens information. Patients were asked to complete an anonymous 15 question survey that focused on lens care--specifically the use of contact lens cleaners, methods of disinfection, enzyme treatments, use of rewetting drops, and the frequency of follow-up exams. In addition, the survey included six true/false questions relating to contact lens care and safety. There were a total of 103 participants in the study. Approximately 24% of patients stated they never cleaned their lenses prior to disinfection, and 5% used saline solutions as their primary mode of disinfection. A sizable portion of those surveyed (43% of soft lens wearers and 71% of rigid gas permeable lens wearers) either never used enzyme cleaners or used them less than once a month. Seventy percent of patients either never used rewetting drops or used them less than once a day. Twenty-nine percent of patients consulted their eye care professionals every 2 years and 6% less often than every two years. Six questions assessed patient knowledge of contact lens care safety. Of a possible six out of six correct answers, the mean number of correct responses was 3.74. A sizable proportion of contact lens wearers do not adequately adhere to recommended contact lens care, and many have an inadequate understanding of contact lens care guidelines. Therefore, it is important that practitioners place more emphasis on patient education at the time of initial contact lens fitting and reinforce such instruction during follow-up visits.

  10. Minimum Lens Size Supporting the Leaky-Wave Nature of Slit Dipole Antenna at Terahertz Frequency

    Directory of Open Access Journals (Sweden)

    Niamat Hussain

    2016-01-01

    Full Text Available We designed a slit dipole antenna backed by an extended hemispherical silicon lens and investigated the minimum lens size in which the slit dipole antenna works as a leaky-wave antenna. The slit dipole antenna consists of a planar feeding structure, which is a center-fed and open-ended slot line. A slit dipole antenna backed by an extended hemispherical silicon lens is investigated over a frequency range from 0.2 to 0.4 THz with the center frequency at 0.3 THz. The numerical results show that the antenna gain responses exhibited an increased level of sensitivity to the lens size and increased linearly with increasing lens radius. The lens with the radius of 1.2λo is found to be the best possible minimum lens size for a slit dipole antenna on an extended hemispherical silicon lens.

  11. Design and testing of a coil-unit barrel for helical coil electromagnetic launcher

    Science.gov (United States)

    Yang, Dong; Liu, Zhenxiang; Shu, Ting; Yang, Lijia; Ouyang, Jianming

    2018-01-01

    A coil-unit barrel for a helical coil electromagnetic launcher is described. It provides better features of high structural strength and flexible adjustability. It is convenient to replace the damaged coil units and easy to adjust the number of turns in the stator coils due to the modular design. In our experiments, the highest velocity measured for a 4.5-kg projectile is 47.3 m/s and the mechanical reinforcement of the launcher could bear 35 kA peak current. The relationship between the energy conversion efficiency and the inductance gradient of the launcher is also studied. In the region of low inductance gradient, the efficiency is positively correlated with the inductance gradient. However, in the region of high inductance gradient, the inter-turn arc erosion becomes a major problem of limiting the efficiency and velocity of the launcher. This modular barrel allows further studies in the inter-turn arc and the variable inductance gradient helical coil launcher.

  12. Effect of infrared radiation on the lens

    Directory of Open Access Journals (Sweden)

    Aly Eman

    2011-01-01

    Full Text Available Background: Infrared (IR radiation is becoming more popular in industrial manufacturing processes and in many instruments used for diagnostic and therapeutic application to the human eye. Aim : The present study was designed to investigate the effect of IR radiation on rabbit′s crystalline lens and lens membrane. Materials and Methods: Fifteen New Zealand rabbits were used in the present work. The rabbits were classified into three groups; one of them served as control. The other two groups were exposed to IR radiation for 5 or 10 minutes. Animals from these two irradiated groups were subdivided into two subgroups; one of them was decapitated directly after IR exposure, while the other subgroup was decapitated 1 hour post exposure. IR was delivered from a General Electric Lamp model 250R 50/10, placed 20 cm from the rabbit and aimed at each eye. The activity of Na + -K + ATPase was measured in the lens membrane. Soluble lens proteins were extracted and the following measurements were carried out: estimation of total soluble protein, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE and Fourier transform infrared (FTIR spectroscopy. For comparison between multiple groups, analysis of variance was used with significance level set at P < 0.001. Results: The results indicated a change in the molecular weight of different lens crystalline accompanied with changes in protein backbone structure. These changes increased for the groups exposed to IR for 10 minutes. Moreover, the activity of Na + -K + ATPase significantly decreased for all groups. Conclusions: The protein of eye lens is very sensitive to IR radiation which is hazardous and may lead to cataract.

  13. [Correct contact lens hygiene].

    Science.gov (United States)

    Blümle, S; Kaercher, T; Khaireddin, R

    2013-06-01

    Although contact lenses have long been established in ophthalmology, practical aspects of handling contact lenses is becoming increasingly less important in the clinical training as specialist for ophthalmology. Simultaneously, for many reasons injuries due to wearing contact lenses are increasing. In order to correct this discrepancy, information on contact lenses and practical experience with them must be substantially increased from a medical perspective. This review article deals with the most important aspects for prevention of complications, i.e. contact lens hygiene.

  14. Theoretical Exploration of Barrel-Shaped Drops on Cactus Spines.

    Science.gov (United States)

    Luo, Cheng

    2015-11-03

    To survive an arid environment, desert cacti are capable of harvesting water from fog by transporting condensed water drops using their spines. Cactus spines have a conical shape. In this work, on the basis of the difference of liquid pressure, a new theoretical model has been developed for a barrel-shaped liquid drop on a conical wire. This model is further simplified to interpret the effects of contact angles, conical angle, surface microgrooves, and gravity on the drop movement along a cactus spine.

  15. The effect of pipecol angles for the magnetic electron lens on the aberration coefficients

    International Nuclear Information System (INIS)

    Al-Khshab, A. M.; Al-Khshab, A. H.

    1997-01-01

    The symmetric mag etic objective lens of great importance for the electronic microscopes intended for hi g resolution. Such lens is determined, not only by its geometries structure and shape parameters, but also by the influence of the variation of the pole piece angles. the results show that the Objective lens having the pole piece angle of 55 a has a considerable effect on the electron optical Properties. When this pole piece is appropriately and highly saturated, the lens possesses low spherical and chromatic aberration coefficients. This hind of pole piece lens leads to more favourable design than other lenses. (authors). 14 refs., 7 figs.1 table

  16. Prolonging contact lens wear and making contact lens wear safer.

    Science.gov (United States)

    Foulks, Gary N

    2006-02-01

    To summarize the present status of safety and efficacy of contact lens wear. Literature review. Ovid Medline searches were performed on records from 1966 through 2005 using keywords: keratitis, contact lens complications, extended-wear contact lenses, and silicone-hydrogel contact lenses. Patients desire comfort, clarity of vision, and prolonged contact lens wear when contact lenses are used to correct refractive error. Practitioners desire patient satisfaction but also require maintenance of the integrity of the eye and no complications that jeopardize vision or health of the eye. Improvements in the oxygen permeability of the contact lens materials, design of the contact lens and its surface, and solutions for the maintenance of the lens have reduced but not eliminated the risks of infection, inflammation, and conjunctival papillary reaction associated with contact lens wear. The lessons of past and recent history suggest that patient education and practitioner participation in the management of contact lens wear continue to be critical factors for patient satisfaction and safety in the extended wear of contact lenses. The availability of highly oxygen permeable contact lenses has increased the tolerance and safety of extended contact lens wear, but patient instruction and education in proper use and care of lenses is required and caution is advised.

  17. First physics pulses in the Barrel Electromagnetic Calorimeter with cosmics

    CERN Multimedia

    Laurent Serin

    2006-01-01

    The electromagnetic barrel calorimeter has been installed in its final position in October 2005. Since then, the calorimeter is being equipped with front-end electronics. Starting in April 2006, electronics calibration runs are taken a few times per week to debug the electronics and to study the performance in the pit (stability, noise). Today, 10 out of the 32 Front End crates are being read out, amounting to about 35000 channels. cool down, few little typos --> After a 6-week cool down, the barrel cryostat was filled with Liquid Argon in May. The presence of a few shorts (~1MΩ) at the edges of the modules was indicating the possibility of conducting dust having entered into the calorimeter with the flowing liquid. In order to try to improve this situation, the calorimeter was emptied and filled again, but this time by condensating the argon instead of flowing it in liquid phase. The new High Voltage tests are not showing any significant improvement but the situation is statisfactory for ATLAS runn...

  18. Recent results from the DELPHI barrel ring imaging Cherenkov counter

    International Nuclear Information System (INIS)

    Anassontzis, E.G.; Ioannou, P.; Kalkanis, G.; Katsanevas, S.; Kontaxis, I.; Kourkoumelis, C.; Nounos, S.; Preve, P.; Resvanis, L.K.; Brunet, J.M.; Dolbeau, J.; Guglielmo, L.; Ledroit, F.; Poutot, D.; Tristram, G.

    1991-01-01

    The DELPHI detector, installed at LEP, is equipped with RICH (Ring Imaging Cherenkov) counters. The Barrel part incorporates a liquid (C 6 F 14 ) and a gaseous (C 5 F 12 ) radiator providing particle identification up to 20GeV/c. The Cherenkov protons of both radiators are detected by TPC-like photon detectors. The drift gas (75% CH 4 + 25% C 2 H 6 ) is doped with TMAE, but which the UV Cherenkov photons are converted into single free photo-electrons. These are drifted towards MWPC's at the end of the drift tubes and the space coordinates of the conversion point are determined. One half of the Barrel RICH is now equipped with drift tubes and has provided results from the liquid radiator since spring 1990. The gas radiator has been tested with C 2 F 6 as a preliminary filling since August 1990. The data obtained demonstrate the good particle identification potential. For the liquid radiator the number of detected photons per ring in hadron jets is N=8, whereas for muon pairs (single tracks) N=10 has been obtained. For the gas radiator 2.1 photons per track were observed, which demonstrates the good functioning of the focussing mirrors, as the C 2 F 6 this is close to the expected value

  19. Performance of a Rain Barrel Sharing Network under Climate Change

    Directory of Open Access Journals (Sweden)

    Seong Jin Noh

    2015-07-01

    Full Text Available Rain barrels can be technically shared through social practices or mutual agreement between individual households. This study proposes the evaluation system for a rain barrel sharing network (RBSN considering three performance criteria of reliability, resiliency, and vulnerability, under plausible climate change scenarios. First, this study shows how the system can be improved in terms of the performance criteria using historical daily rainfall data based on the storage-reliability-yield relationship. This study then examined how the benefits from RBSN are affected by climate change after 100 years. Three climate change scenarios (A1B, A2 and B2 and three global circulation models were used for this purpose. The results showed that the reliability and vulnerability are improved due to sharing and their improvements become larger under climate change conditions. In contrast, the resiliency reduces slightly due to sharing and its reduction is attenuated under climate change conditions. In particular, vulnerability will be reduced significantly under climate change. These results suggest that the sharing of various water resources systems can be an effective climate change adaptation strategy that reduces vulnerability and increases the reliability of the system.

  20. Vortexlike Power Flow at the Interfaces of Metamaterial Lens

    Directory of Open Access Journals (Sweden)

    K. Fang

    2012-10-01

    Full Text Available The metamaterial lens with DPS/DNS/DPS structure has been realized by using the two-dimensional (2D isotropic transmission line approach. We studied the vortexlike power flow at the interfaces of metamaterial lens and validated by the finite-difference time-domain (FDTD simulator. The computational results showing its different conditions near DPS/DNS and other kinds of interfaces are obtained by CST STUDIO SUITE at different frequencies, and demonstrate the intuitionistic power location at the metamaterial lens interfaces.

  1. Design, Performance, and Calibration of CMS Hadron-Barrel Calorimeter Wedges

    CERN Document Server

    Baiatian, G; Emeliantchik, Igor; Massolov, V; Shumeiko, Nikolai; Stefanovich, R; Damgov, Jordan; Dimitrov, Lubomir; Genchev, Vladimir; Piperov, Stefan; Vankov, Ivan; Litov, Leander; Bencze, Gyorgy; Vesztergombi, Gyorgy; Zálán, Peter; Bawa, Harinder Singh; Beri, Suman Bala; Bhatnagar, Vipin; Kaur, Manjit; Kohli, Jatinder Mohan; Kumar, Arun; Singh, Jas Bir; Acharya, Bannaje Sripathi; Banerjee, Sunanda; Banerjee, Sudeshna; Chendvankar, Sanjay; Dugad, Shashikant; Kalmani, Suresh Devendrappa; Katta, S; Mazumdar, Kajari; Mondal, Naba Kumar; Nagaraj, P; Patil, Mandakini Ravindra; Reddy, L; Satyanarayana, B; Sudhakar, Katta; Verma, Piyush; Paktinat, S; Golutvin, Igor; Kalagin, Vladimir; Kosarev, Ivan; Mescheryakov, G; Sergeyev, S; Smirnov, Vitaly; Volodko, Anton; Zarubin, Anatoli; Gavrilov, Vladimir; Gershtein, Yuri; Kaftanov, Vitali; Kisselevich, I; Kolossov, V; Krokhotin, Andrey; Kuleshov, Sergey; Litvintsev, Dmitri; Stolin, Viatcheslav; Ulyanov, A; Demianov, A; Gribushin, Andrey; Kodolova, Olga; Petrushanko, Sergey; Sarycheva, Ludmila; Vardanyan, Irina; Yershov, A; Abramov, Victor; Goncharov, Petr; Khmelnikov, Alexander; Korablev, Andrey; Korneev, Yury; Krinitsyn, Alexander; Kryshkin, V; Lukanin, Vladimir; Pikalov, Vladimir; Ryazanov, Anton; Talov, Vladimir; Turchanovich, L; Volkov, Alexey; Camporesi, Tiziano; De Visser, Theo; Vlassov, E; Aydin, Sezgin; Dumanoglu, Isa; Eskut, Eda; Kayis-Topaksu, A; Kuzucu-Polatoz, A; Onengüt, G; Ozdes-Koca, N; Cankocak, Kerem; Ozok, Ferhat; Serin-Zeyrek, M; Sever, Ramazan; Zeyrek, Mehmet; Gülmez, Erhan; Isiksal, Engin; Kaya, Mithat; Ozkorucuklu, Suat; Levchuk, Leonid; Sorokin, Pavel; Grinev, B; Lubinsky, V; Senchishin, V; Anderson, E Walter; Hauptman, John M; Elias, John E; Elvira, D; Freeman, Jim; Green, Dan; Lazic, Dragoslav; Los, Serguei; O'Dell, Vivian; Ronzhin, Anatoly; Suzuki, Ichiro; Vidal, Richard; Whitmore, Juliana; Antchev, Georgy; Hazen, Eric; Lawlor, C; Machado, Emanuel; Posch, C; Rohlf, James; Wu, Shouxiang; Adams, Mark Raymond; Burchesky, Kyle; Qiang, W; Abdullin, Salavat; Baden, Drew; Bard, Robert; Eno, Sarah Catherine; Grassi, Tullio; Jarvis, Chad; Kellogg, Richard G; Kunori, Shuichi; Skuja, Andris; Podrasky, V; Sanzeni, Christopher; Winn, Dave; Akgun, Ugur; Ayan, S; Duru, Firdevs; Merlo, Jean-Pierre; Mestvirishvili, Alexi; Miller, Michael; Norbeck, Edwin; Olson, Jonathan; Onel, Yasar; Schmidt, Ianos; Akchurin, Nural; Carrell, Kenneth Wayne; Gumu, K; Thomas, Ray; Baarmand, Marc M; Ralich, Robert; Vodopiyanov, Igor; Cushman, Priscilla; Heering, Arjan Hendrix; Sherwood, Brian; Cremaldi, Lucien Marcus; Reidy, Jim; Sanders, David A; Karmgard, Daniel John; Ruchti, Randy; Fisher, Wade Cameron; Mans, Jeremy; Tully, Christopher; De Barbaro, Pawel; Bodek, Arie; Budd, Howard; Chung, Yeon Sei; Haelen, T; Imboden, Matthias; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Barnes, Virgil E; Laasanen, Alvin T; Pompos, Arnold

    2007-01-01

    Extensive measurements have been made with pions, electrons and muons on four production wedges of the Compact Muon Solenoid (CMS) hadron barrel (HB) calorimeter in the H2 beam line at CERN with particle momenta varying from 20 to 300 GeV/c. Data were taken both with and without a prototype electromagnetic lead tungstate crystal calorimeter (EB) in front of the hadron calorimeter. The time structure of the events was measured with the full chain of preproduction front-end electronics running at 34 MHz. Moving-wire radioactive source data were also collected for all scintillator layers in the HB. These measurements set the absolute calibration of the HB prior to first pp collisions to approximately 4%.

  2. The Design and Performance of a Twenty Barrel Hydrogen Pellet Injector for Alcator C-Mod

    Science.gov (United States)

    Urbahn, John A.

    A twenty barrel hydrogen pellet injector has been designed, built and tested both in the laboratory and on the Alcator C-Mod Tokamak at MIT. The injector functions by firing pellets of frozen hydrogen or deuterium deep into the plasma discharge for the purpose of fueling the plasma, modifying the density profile and increasing the global energy confinement time. The design goals of the injector are: (1) Operational flexibility, (2) High reliability, (3) Remote operation with minimal maintenance. These requirements have led to a single stage, pipe gun design with twenty barrels. Pellets are formed by in-situ condensation of the fuel gas, thus avoiding moving parts at cryogenic temperatures. The injector is the first to dispense with the need for cryogenic fluids and instead uses a closed cycle refrigerator to cool the thermal system components. The twenty barrels of the injector produce pellets of four different size groups and allow for a high degree of flexibility in fueling experiments. Operation of the injector is under PLC control allowing for remote operation, interlocked safety features and automated pellet manufacturing. The injector has been extensively tested and shown to produce pellets reliably with velocities up to 1400 m/sec. During the period from September to November of 1993, the injector was successfully used to fire pellets into over fifty plasma discharges. Experimental results include data on the pellet penetration into the plasma using an advanced pellet tracking diagnostic with improved time and spatial response. Data from the tracker indicates pellet penetrations were between 30 and 86 percent of the plasma minor radius. Line averaged density increases of up to 300 percent were recorded with peak densities of just under 1 times 10^ {21} / m^3, the highest achieved on C-Mod to date. A comparison is made between the ablation source function derived from tracker data with that predicted by four different variations of the neutral shield model

  3. Patchwork-Type Spontaneous Activity in Neonatal Barrel Cortex Layer 4 Transmitted via Thalamocortical Projections

    Directory of Open Access Journals (Sweden)

    Hidenobu Mizuno

    2018-01-01

    Full Text Available Summary: Establishment of precise neuronal connectivity in the neocortex relies on activity-dependent circuit reorganization during postnatal development; however, the nature of cortical activity during this period remains largely unknown. Using two-photon calcium imaging of the barrel cortex in vivo during the first postnatal week, we reveal that layer 4 (L4 neurons within the same barrel fire synchronously in the absence of peripheral stimulation, creating a “patchwork” pattern of spontaneous activity corresponding to the barrel map. By generating transgenic mice expressing GCaMP6s in thalamocortical axons, we show that thalamocortical axons also demonstrate the spontaneous patchwork activity pattern. Patchwork activity is diminished by peripheral anesthesia but is mostly independent of self-generated whisker movements. The patchwork activity pattern largely disappeared during postnatal week 2, as even L4 neurons within the same barrel tended to fire asynchronously. This spontaneous L4 activity pattern has features suitable for thalamocortical (TC circuit refinement in the neonatal barrel cortex. : By two-photon calcium imaging of layer 4 neurons and thalamocortical axon terminals in neonatal mouse barrel cortex, Mizuno et al. find a patchwork-like spontaneous activity pattern corresponding to the barrel map, which may be important for thalamocortical circuit maturation. Keywords: activity-dependent development, spontaneous activity, synchronized activity, barrel cortex, thalamocortical axons, neonates, in vivo calcium imaging, awake, single-cell labeling, whisker monitoring

  4. Design and development of a work robot to place ATLAS SCT modules onto barrel cylinders

    CERN Document Server

    Terada, S; Honma, F; Ikegami, Y; Iwata, Y; Kato, Y; Kobayashi, H; Kohriki, T; Kondo, T; Nakano, I; Sengoku, H; Takashima, R; Tanaka, R; Ujiie, N; Unno, Y; Yasuda, S

    2005-01-01

    More than 2000 silicon modules need to be placed and fastened on the ATLAS SCT barrel tracker. A semi-automatic pick-and-place work robot was designed and developed to cope with the module placement for the SCT barrel assembly. We found that this robot could place modules to a mechanical precision of better than 25 mum.

  5. Compliance among soft contact lens wearers.

    OpenAIRE

    Kuzman, Tomislav; Barišić Kutija, Marija; Masnec, Sanja; Jandroković, Sonja; Mrazovac, Danijela; Jurišić, Darija; Škegro, Ivan; Kalauz, Miro; Kordić, Rajko

    2014-01-01

    Contact lens compliance is proven to be crucial for preventing lens wear-related complications because of the interdependence of the steps in lens care regime and their influence on lens system microbial contamination. Awareness of the patients' lens handling compliance as well as correct recognition of non-compliant behaviours is the basis for creating more targeted strategies for patient education. The aim of this study was to investigate compliance among soft contact lens (SCL) wearers in ...

  6. Panoramic lens applications revisited

    Science.gov (United States)

    Thibault, Simon

    2008-04-01

    During the last few years, innovative optical design strategies to generate and control image mapping have been successful in producing high-resolution digital imagers and projectors. This new generation of panoramic lenses includes catadioptric panoramic lenses, panoramic annular lenses, visible/IR fisheye lenses, anamorphic wide-angle attachments, and visible/IR panomorph lenses. Given that a wide-angle lens images a large field of view on a limited number of pixels, a systematic pixel-to-angle mapping will help the efficient use of each pixel in the field of view. In this paper, we present several modern applications of these modern types of hemispheric lenses. Recently, surveillance and security applications have been proposed and published in Security and Defence symposium. However, modern hemispheric lens can be used in many other fields. A panoramic imaging sensor contributes most to the perception of the world. Panoramic lenses are now ready to be deployed in many optical solutions. Covered applications include, but are not limited to medical imaging (endoscope, rigiscope, fiberscope...), remote sensing (pipe inspection, crime scene investigation, archeology...), multimedia (hemispheric projector, panoramic image...). Modern panoramic technologies allow simple and efficient digital image processing and the use of standard image analysis features (motion estimation, segmentation, object tracking, pattern recognition) in the complete 360° hemispheric area.

  7. The CMS Level-1 Trigger Barrel Track Finder

    International Nuclear Information System (INIS)

    Ero, J.; Wulz, C.; Evangelou, I.; Flouris, G.; Foudas, C.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Guiducci, L.; Sotiropoulos, S.; Sphicas, P.; Triossi, A.

    2016-01-01

    The design and performance of the upgraded CMS Level-1 Trigger Barrel Muon Track Finder (BMTF) is presented. Monte Carlo simulation data as well as cosmic ray data from a CMS muon detector slice test have been used to study in detail the performance of the new track finder. The design architecture is based on twelve MP7 cards each of which uses a Xilinx Virtex-7 FPGA and can receive and transmit data at 10 Gbps from 72 input and 72 output fibers. According to the CMS Trigger Upgrade TDR the BMTF receives trigger primitive data which are computed using both RPC and DT data and transmits data from a number of muon candidates to the upgraded Global Muon Trigger. Results from detailed studies of comparisons between the BMTF algorithm results and the results of a C++ emulator are also presented. The new BMTF will be commissioned for data taking in 2016

  8. Performance of the ATLAS electromagnetic calorimeter barrel module 0

    CERN Document Server

    Aubert, Bernard; Alexa, C; Astesan, F; Augé, E; Aulchenko, V M; Ballansat, J; Barreiro, F; Barrillon, P; Battistoni, G; Bazan, A; Beaugiraud, B; Beck-Hansen, J; Belhorma, B; Belorgey, J; Belymam, A; Ben-Mansour, A; Benchekroun, D; Benchouk, C; Bernard, R; Bertoli, W; Boniface, J; Bonivento, W; Bourdarios, C; Bremer, J; Breton, D; Bán, J; Camard, A; Canton, B; Carminati, L; Cartiglia, N; Cavalli, D; Chalifour, M; Chekhtman, A; Chen, H; Cherkaoui, R; Chevalley, J L; Chollet, F; Citterio, M; Clark, A; Cleland, W; Clément, C; Colas, Jacques; Collot, J; Costa, G; Cros, P; Cunitz, H; de Saintignon, P; Del Peso, J; Delebecque, P; Delmastro, M; Di Ciaccio, Lucia; Dinkespiler, B; Djama, F; Dodd, J; Driouichi, C; Dumont-Dayot, N; Duval, P Y; Dzahini, D; Efthymiopoulos, I; Egdemir, J; El-Kacimi, M; El-Mouahhidi, Y; Engelmann, R; Ernwein, J; Falleau, I; Fanti, M; Farrell, J; Fassnacht, P; Ferrari, A; Fichet, S; Fournier, D; Gallin-Martel, M L; Gara, A; García, G; Gaumer, O; Ghazlane, H; Ghez, P; Gianotti, F; Girard, C; Gordon, H; Gouanère, M; Guilhem, G; Hackenburg, B; Hakimi, M; Hassani, S; Henry-Coüannier, F; Hervás, L; Hinz, L; Hoffman, A; Hoffman, J; Hostachy, J Y; Hoummada, A; Hubaut, F; Idrissi, A; Imbault, D; Jacquier, Y; Jérémie, A; Jevaud, M; Jézéquel, S; Kambara, H; Karst, P; Kazanin, V; Kierstead, J A; Kolachev, G M; Kordas, K; de La Taille, C; Labarga, L; Lacour, D; Lafaye, R; Laforge, B; Lanni, F; Le Coroller, A; Le Dortz, O; Le Maner, C; Le Van-Suu, A; Le Flour, T; Leite, M; Leltchouk, M; Lesueur, J; Lissauer, D; Lund-Jensen, B; Lundqvist, J M; Ma, H; Macé, G; Makowiecki, D S; Malychev, V; Mandelli, L; Mansoulié, B; Marin, C P; Martin, D; Martin, L; Martin, O; Martin, P; Maslennikov, A L; Massol, N; Mazzanti, M; McCarthy, R; McDonald, J; Megner, L; Merkel, B; Mirea, A; Moneta, L; Monnier, E; Moynot, M; Muraz, J F; Nagy, E; Negroni, S; Neukermans, L; Nicod, D; Nikolic-Audit, I; Noppe, J M; Ohlsson-Malek, F; Olivier, C; Orsini, F; Pailler, P; Parrour, G; Parsons, J A; Pearce, M; Perini, L; Perrodo, P; Perrot, G; Pétroff, P; Poggioli, Luc; Pospelov, G E; Pralavorio, Pascal; Prast, J; Przysiezniak, H; Puzo, P; Radeka, V; Rahm, David Charles; Rajagopalan, S; Raymond, M; Renardy, J F; Repetti, B; Rescia, S; Resconi, S; Riccadona, X; Richer, J P; Rijssenbeek, M; Rodier, S; Rossel, F; Rousseau, D; Rydström, S; Saboumazrag, S; Sauvage, D; Sauvage, G; Schilly, P; Schwemling, P; Schwindling, J; Seguin-Moreau, N; Seidl, W; Seman, M; Serin, L; Shousharo, A; Simion, S; Sippach, W; Snopkov, R; Steffens, J; Stroynowski, R; Stumer, I; Taguet, J P; Takai, H; Talyshev, A A; Tartarelli, F; Teiger, J; Thion, J; Tikhonov, Yu A; Tisserant, S; Tocut, V; Tóth, J; Veillet, J J; Vossebeld, Joost Herman; Vuillemin, V; Wielers, M; Willis, W J; Wingerter-Seez, I; Ye, J; Yip, K; Zerwas, D; Zitoun, R; Zolnierowski, Y

    2003-01-01

    The construction and performance of the barrel pre-series module 0 of the future ATLAS electromagnetic calorimeter at the LHC is described. The signal reconstruction and performance of ATLAS-like electronics has been studied. The signal to noise ratio for muons has been found to be 7.11+-0.07. An energy resolution of better than 9.5% GeV^1/2/sqrt{E} (sampling term) has been obtained with electron beams of up to 245GeV. The uniformity of the response to electrons in an area of Delta_eta x Delta_phi = 1.2 x 0.075 has been measured to be better than 0.8%.

  9. Manufacturing aspects of the ATLAS barrel toroid double pancakes

    CERN Document Server

    Drago, G; Gagliardi, P; Laurenti, A; Marabotto, R; Penco, R

    2002-01-01

    In 1999 INFN (Istituto Nazionale di Fisica Nucleare) ordered to ANSALDO the manufacturing of 16 double pancakes for the ATLAS BARREL TOROID. In July 2001 four Double Pancakes have already been completed and shipped to the integration site. In this paper the main aspects of the manufacturing of the largest superconducting coils ever built (5*25 m) are described. The main phases of the manufacturing procedure are reviewed starting from the conductor preparation to the VPI impregnation, including references to the materials used as well as to the relevant customer's requirements. In particular the special winding form and the winding technique are treated. For each phase the most critical aspects and the relevant solutions are pointed out. Particular details about the technical solutions adopted for the impregnation and curing of the Double Pancake, which could not be performed inside an autoclave due to the huge dimension of the coil itself, are reported. Finally the methods used for the dimensional and electri...

  10. Performance of the ATLAS electromagnetic calorimeter barrel module 0

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.; Ballansat, J.; Bazan, A.; Beaugiraud, B.; Boniface, J.; Chollet, F.; Colas, J.; Delebecque, P.; Di Ciaccio, L.; Dumont-Dayot, N.; El Kacimi, M.; Gaumer, O.; Ghez, P.; Girard, C.; Gouanere, M.; Kambara, H.; Jeremie, A.; Jezequel, S.; Lafaye, R.; Leflour, T.; Le Maner, C.; Lesueur, J.; Massol, N.; Moynot, M.; Neukermans, L.; Perrodo, P.; Perrot, G.; Poggioli, L.; Prast, J.; Przysiezniak, H.; Riccadona, X.; Sauvage, G.; Thion, J.; Wingerter-Seez, I.; Zitoun, R.; Zolnierowski, Y.; Chen, H.; Citterio, M.; Farrell, J.; Gordon, H.; Hackenburg, B.; Hoffman, A.; Kierstead, J.; Lanni, F.; Leite, M.; Lissauer, D.; Ma, H.; Makowiecki, D.; Radeka, V.; Rahm, D.; Rajagopalan, S.; Rescia, S.; Stumer, I.; Takai, H.; Yip, K.; Benchekroun, D.; Driouichi, C.; Hoummada, A.; Hakimi, M.; Stroynowski, R.; Ye, J.; Beck Hansen, J.; Belymam, A.; Bremer, J.; Chevalley, J.L.; Fassnacht, P.; Gianotti, F.; Hervas, L.; Marin, C.P.; Pailler, P.; Schilly, P.; Seidl, W.; Vossebeld, J.; Vuillemin, V.; Clark, A.; Efthymiopoulos, I.; Moneta, L.; Belhorma, B.; Collot, J.; Saintignon, P. de; Dzahini, D.; Ferrari, A.; Gallin-Martel, M.L.; Hostachy, J.Y.; Martin, P.; Muraz, J.F.; Ohlsson-Malek, F.; Saboumazrag, S.; Ban, J.; Cartiglia, N.; Cunitz, H.; Dodd, J.; Gara, A.; Leltchouk, M.; Negroni, S.; Parsons, J.A.; Seman, M.; Simion, S.; Sippach, W.; Willis, W.; Barreiro, F.; Garcia, G.; Labarga, L.; Rodier, S.; Peso, J. del; Alexa, C.; Barrillon, P.; Benchouk, C.; Chekhtman, A.; Dinkespiler, B.; Djama, F.; Duval, P.Y.; Henry-Couannier, F.; Hinz, L.; Jevaud, M.; Karst, P.; Le Van Suu, A.; Martin, L.; Martin, O.; Mirea, A.; Monnier, E.; Nagy, E.; Nicod, D.; Olivier, C.; Pralavorio, P.; Repetti, B.; Raymond, M.; Sauvage, D.; Tisserant, S.; Toth, J.; Wielers, M.; Battistoni, G.; Bonivento, W.; Carminati, L.; Cavalli, D.; Costa, G.; Delmastro, M.; Fanti, M.; Mandelli, L.; Mazzanti, M.; Perini, L.; Resconi, S.; Tartarelli, G.F.; Aulchenko, V.; Kazanin, V.; Kolachev, G.; Malyshev, V.J. [and others

    2003-03-11

    The construction and performance of the barrel pre-series module 0 of the future ATLAS electromagnetic calorimeter at the LHC is described. The signal reconstruction and performance of ATLAS-like electronics has been studied. The signal to noise ratio for muons has been found to be 7.11{+-}0.07. An energy resolution of better than 9.5% GeV{sup 1/2}/{radical}E (sampling term) has been obtained with electron beams of up to 245 GeV. The uniformity of the response to electrons in an area of {delta}{eta}x{delta}phi=1.2x0.075 has been measured to be better than 0.8%.

  11. The ATLAS Barrel Level-1 Muon Trigger Calibration

    CERN Document Server

    Ciapetti, G; Petrolo, E; Rosati, S; Spila, F; Vari, R; Veneziano, S; Zanello, L; 12th Workshop on Electronics For LHC and Future Experiments

    2007-01-01

    The ATLAS experiment uses a system of three concentric Resistive Plate Chambers detectors layers for the level-1 muon trigger in the air-core barrel toroid region. The trigger classifies muons within different programmable transverse momentum ranges, and tags the identified tracks with the corresponding bunch crossing number. The algorithm looks for hit coincidences within different detector layers inside the programmed geometrical road which defines the transverse momentum cut. The on-detector electronics providing the trigger and detector readout functionalities collects input signals coming from the RPC front-end. Because of the different time-of-flights and cables and optical fibres lengths, signals have to be adjusted in time in order to be correctly aligned before being processed. Programmable delay logics are provided in the trigger and readout system to allow for time adjustment, for hit signals as well as for LHC Timing, Trigger and Control signals. The trigger calibration provides the set of numbers...

  12. Alcohol dehydrogenase polymorphism in barrel cactus populations of Drosophila mojavensis.

    Science.gov (United States)

    Cleland, S; Hocutt, G D; Breitmeyer, C M; Markow, T A; Pfeiler, E

    1996-07-01

    Starch gel electrophoresis revealed that the alcohol dehydrogenase (ADH-2) locus was polymorphic in two populations (from Agua Caliente, California and the Grand Canyon, Arizona) of cactophilic Drosophila mojavensis that utilize barrel cactus (Ferocactus acanthodes) as a host plant. Electromorphs representing products of a slow (S) and a fast (F) allele were found in adult flies. The frequency of the slow allele was 0.448 in flies from Agua Caliente and 0.659 in flies from the Grand Canyon. These frequencies were intermediate to those of the low (Baja California peninsula, Mexico) and high (Sonora, Mexico and southern Arizona) frequency Adh-2S populations of D. mojavensis that utilize different species of host cacti.

  13. A radial map of multi-whisker correlation selectivity in the rat barrel cortex.

    Science.gov (United States)

    Estebanez, Luc; Bertherat, Julien; Shulz, Daniel E; Bourdieu, Laurent; Léger, Jean-François

    2016-11-21

    In the barrel cortex, several features of single-whisker stimuli are organized in functional maps. The barrel cortex also encodes spatio-temporal correlation patterns of multi-whisker inputs, but so far the cortical mapping of neurons tuned to such input statistics is unknown. Here we report that layer 2/3 of the rat barrel cortex contains an additional functional map based on neuronal tuning to correlated versus uncorrelated multi-whisker stimuli: neuron responses to uncorrelated multi-whisker stimulation are strongest above barrel centres, whereas neuron responses to correlated and anti-correlated multi-whisker stimulation peak above the barrel-septal borders, forming rings of multi-whisker synchrony-preferring cells.

  14. Tunable Focus Liquid Lens with Radial-Patterned Electrode

    Directory of Open Access Journals (Sweden)

    Miao Xu

    2015-08-01

    Full Text Available A dielectric liquid lens is prepared based on our previous work. By optimizing the device structure, the liquid lens presents a converging focus with good resolution and changes its focal length over a broad range with a low driving voltage. For a liquid lens with ~2.3 mm diameter in the relaxed state, it can resolve ~40 lp/mm. The resolution does not degrade during focus change. Its focal length can be varied from ~12 to ~5 mm when the applied voltage is changed from 0 to 28 Vrms. The response time of one cycle is ~2.5 s. Our liquid lens, with a low driving voltage for a large dynamic range, has potential applications in imaging, biometrics, optoelectronic, and lab-on-chip devices.

  15. Effects of Temperature on Hybrid Lens Performance

    Science.gov (United States)

    Askins, Steve; Victoria, Marta; Herrero, Rebeca; Domínguez, César; Antón, Ignacio; Sala, Gabriel

    2011-12-01

    In hybrid Silicone-on-glass Fresnel lenses, an optical silicone is molded onto a glass substrate and forms the Fresnel structure. These lenses offer a cost effective solution as a primary optical element in point-focus concentrator photovoltaic modules, as well as performance advantages. However, these lenses have a high performance variation with temperature due both to the change in index of refraction of silicone as well as to deformations in the facets caused by coefficient of thermal expansion (CTE) mismatch. In this study we perform measurements of the light flux at the focal plane of a family of SOG lenses, varying temperature and lens-to-receiver distances. The effect of varying silicone cure temperature and the depth of the silicone between the lens and the glass substrate on temperature dependence was investigated. A preliminary computer model of this behavior is presented.

  16. Development of high precision and cryogenic lens holders

    Science.gov (United States)

    Reutlinger, A.; Boesz, Anton; Mottaghibonab, A.; Eckert, P.; Dubowy, M.; Gebler, H.; Grupp, F.; Geis, N.; Bode, A.; Katterloher, R.; Bender, R.

    2017-11-01

    The optical system of the Near Infrared Spectrometer and Photometer (NISP) of the EUCLID mission consists mainly of a filter and grism wheel and 4 aspherical lenses with large diameters up to 170 mm. The single lenses require a high precision positioning at the operational temperature of 150 K. An additional design driver represents the CaF2 material of a lens, which is very sensitive wrt brittleness. The technical maturity of the combination of single features such as CaF2, large diameter (and mass), high precision and cryogenic conditions is considered as low. Therefore, a dedicated pre-development program has been launched to design and develop a first prototype of lens holder and to demonstrate the functional performance at representative operational conditions. The 4 lenses are divided into 3x lenses for the Camera Lens Assembly (CaLA) and 1x lens for the Corrector Lens Assembly (CoLA). Each lens is glue mounted onto solid state springs, part of an adaption ring. The adaption ring shall provide protection against vibration loads, high accuracy positioning, as well as quasi load free mounting of the lens under operational conditions. To reduce thermomechanical loads on the lens, the CTE of the adaption ring is adapted to that of the lens. The glue between lens and solid state spring has to withstand high tension loads during vibration. At the operational temperature the deviating CTE between glue and lens/adaption ring introduces shear loads into the glue interface, which are critical, in particular for the fragile CaF2 lens material. For the case of NISP the shear loads are controlled with the glue pad diameter and the glue thickness. In the context of the development activity many technology aspects such as various solid state spring designs, glue selection and glue handling have been investigated. A parametric structural model was developed to derive the specific design feature of each ring, such as spring force, number of springs, eigenfrequency, etc. This

  17. Crystalline lens radioprotectors

    International Nuclear Information System (INIS)

    Belkacemi, Y.; Pasquier, D.; Castelain, B.; Lartigau, E.; Warnet, J.M.

    2003-01-01

    During more than a half of century, numerous compounds have been tested in different models against radiation-induced cataract. In this report, we will review the radioprotectors that have been already tested for non-human crystalline lens protection. We will focus on the most important published studies in this topic and the mechanisms of cyto-protection reported in. vitro and in. vivo from animals. The most frequent mechanisms incriminated in the cyto-protective effect are: free radical scavenging, limitation of lipid peroxidation, modulation of cycle progression increase of intracellular reduced glutathione pool, reduction of DNA strand breaks and limitation of apoptotic cell death. Arnifostine (or Ethyol) and anethole dithiolethione (or Sulfarlem), already used clinically as chemo- and radio-protectants, could be further test?r for ocular radioprotection particularly for radiation-induced cataract. (author)

  18. Contact Lens Wear at Altitude: Subcontact Lens Bubble Formation

    Science.gov (United States)

    1987-11-01

    incidence of (PMMA) lenses . Reported here are the results of contact lens subcontact lens bubble formation under scleral lenses at bubble studies with soft...vision from formation of large bubbles greater than 6,096 m (20,000 It). With soft contact lenses , bubble under their contact lenses . They also found...always located at the limbus and were without sequela to vision or corneal epithelial integrity. scleral lenses used by Jaeckle were permeable to gases

  19. Straylight Measurements in Contact Lens Wear

    NARCIS (Netherlands)

    van der Meulen, Ivanka J. E.; Engelbrecht, Leonore A.; van Vliet, Johannes M. J.; Lapid-Gortzak, Ruth; Nieuwendaal, Carla P.; Mourits, Maarten P.; Schlingemann, Reinier O.; van den Berg, Thomas J. T. P.

    2010-01-01

    Purpose: (1) To quantify the effect of contact lens wear on straylight in rigid and soft contact lens wearers and (2) to relate findings to morphological changes and subjective complaints. Methods: Straylight was measured using the Oculus C-Quant during contact lens wear and after contact lens

  20. Geometric calibration of lens and filter distortions for multispectral filter-wheel cameras.

    Science.gov (United States)

    Brauers, Johannes; Aach, Til

    2011-02-01

    High-fidelity color image acquisition with a multispectral camera utilizes optical filters to separate the visible electromagnetic spectrum into several passbands. This is often realized with a computer-controlled filter wheel, where each position is equipped with an optical bandpass filter. For each filter wheel position, a grayscale image is acquired and the passbands are finally combined to a multispectral image. However, the different optical properties and non-coplanar alignment of the filters cause image aberrations since the optical path is slightly different for each filter wheel position. As in a normal camera system, the lens causes additional wavelength-dependent image distortions called chromatic aberrations. When transforming the multispectral image with these aberrations into an RGB image, color fringes appear, and the image exhibits a pincushion or barrel distortion. In this paper, we address both the distortions caused by the lens and by the filters. Based on a physical model of the bandpass filters, we show that the aberrations caused by the filters can be modeled by displaced image planes. The lens distortions are modeled by an extended pinhole camera model, which results in a remaining mean calibration error of only 0.07 pixels. Using an absolute calibration target, we then geometrically calibrate each passband and compensate for both lens and filter distortions simultaneously. We show that both types of aberrations can be compensated and present detailed results on the remaining calibration errors.

  1. Syria: a waited petroleum production of 600 000 barrels per day for the end of 1993

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    This paper describes the reserves of petroleum deposits and gives statistical data on the production of the main oil fields in Syria. Petroleum production has grown from 160000 barrels per day in 1984 to 515000 barrels per day in 1992 and a production at a level of 600000 barrels per day is waited in 1993. Several petroleum companies, operating in Syria, have contributed to this rise, especially Al-Furat Petroleum Company (AFPC), joint venture between Syrian Petroleum Company (SPC) and Pecten/Shell/Deminex, followed by Deiz Ezzor Petroleum Company (DEZPC), association between the french company Elf Aquitaine and SPC. 2 tabs

  2. Presbyopia and heat: changes associated with aging of the human lens suggest a functional role for the small heat shock protein, alpha-crystallin, in maintaining lens flexibility.

    Science.gov (United States)

    Heys, Karl R; Friedrich, Michael G; Truscott, Roger J W

    2007-12-01

    Presbyopia, the inability to focus up close, affects everyone by age 50 and is the most common eye condition. It is thought to result from changes to the lens over time making it less flexible. We present evidence that presbyopia may be the result of age-related changes to the proteins of the lens fibre cells. Specifically, we show that there is a progressive decrease in the concentration of the chaperone, alpha-crystallin, in human lens nuclei with age, as it becomes incorporated into high molecular weight aggregates and insoluble protein. This is accompanied by a large increase in lens stiffness. Stiffness increases even more dramatically after middle age following the disappearance of free soluble alpha-crystallin from the centre of the lens. These alterations in alpha-crystallin and aggregated protein in human lenses can be reproduced simply by exposing intact pig lenses to elevated temperatures, for example, 50 degrees C. In this model system, the same protein changes are also associated with a progressive increase in lens stiffness. These data suggest a functional role for alpha-crystallin in the human lens acting as a small heat shock protein and helping to maintain lens flexibility. Presbyopia may be the result of a loss of alpha-crystallin coupled with progressive heat-induced denaturation of structural proteins in the lens during the first five decades of life.

  3. Geometry-invariant GRIN lens: iso-dispersive contours

    Science.gov (United States)

    Bahrami, Mehdi; Goncharov, Alexander V.

    2012-01-01

    A dispersive model of a gradient refractive index (GRIN) lens is introduced based on the idea of iso-dispersive contours. These contours have constant Abbe number and their shape is related to iso-indicial contours of the monochromatic geometry-invariant GRIN lens (GIGL) model. The chromatic GIGL model predicts the dispersion throughout the GRIN structure by using the dispersion curves of the surface and the center of the lens. The analytical approach for paraxial ray tracing and the monochromatic aberration calculations used in the GIGL model is employed here to derive closed-form expressions for the axial and lateral color coefficients of the lens. Expressions for equivalent refractive index and the equivalent Abbe number of the homogeneous equivalent lens are also presented and new aspects of the chromatic aberration change due to aging are discussed. The key derivations and explanations of the GRIN lens optical properties are accompanied with numerical examples for the human and animal eye GRIN lenses. PMID:22808438

  4. Adaptive Liquid Lens Actuated by Droplet Movement

    Directory of Open Access Journals (Sweden)

    Chao Liu

    2014-08-01

    Full Text Available In this paper we report an adaptive liquid lens actuated by droplet movement. Four rectangular PMMA (Polymethyl Methacrylate substrates are stacked to form the device structure. Two ITO (Indium Tin Oxide sheets stick on the bottom substrate. One PMMA sheet with a light hole is inserted in the middle of the device. A conductive droplet is placed on the substrate and touches the PMMA sheet to form a small closed reservoir. The reservoir is filled with another immiscible non-conductive liquid. The non-conductive liquid can form a smooth concave interface with the light hole. When the device is applied with voltage, the droplet stretches towards the reservoir. The volume of the reservoir reduces, changing the curvature of the interface. The device can thus achieve the function of an adaptive lens. Our experiments show that the focal length can be varied from −10 to −159 mm as the applied voltage changes from 0 to 65 V. The response time of the liquid lens is ~75 ms. The proposed device has potential applications in many fields such as information displays, imaging systems, and laser scanning systems.

  5. Tear film evaluation and management in soft contact lens wear: a systematic approach.

    Science.gov (United States)

    Downie, Laura E; Craig, Jennifer P

    2017-09-01

    The human tear film is a highly ordered structure consisting of a thin layer of lipid on the surface and a thicker aqueous-mucin phase, which increases in mucin concentration toward the corneal epithelial cell layer. The health of the tear film and ocular surface influences the likelihood of being able to achieve successful contact lens wear. Contact lens discomfort and dryness are the most frequent reasons why contact lens wearers experience reduced wearing times, which can eventually lead to contact lens discontinuation. Comprehensive clinical assessment of tear film integrity and ocular surface health is therefore essential prior to commencing contact lens wear, to enable the ocular surface environment to be optimised to support lens wear. These parameters should also be evaluated over the course of contact lens wear, in order to identify any aspects requiring clinical management and ensure maintenance of optimal lens-wearing conditions. This review summarises current knowledge relating to the effects of soft contact lens wear on the tear film and ocular surface. It also provides a systematic approach to evaluating tear film and ocular surface integrity, in order to guide the clinical management of tear film anomalies with respect to contact lens wear. © 2017 Optometry Australia.

  6. Contact Lens Related Corneal Ulcer

    OpenAIRE

    Loh, KY; Agarwal, P

    2010-01-01

    A corneal ulcer caused by infection is one of the major causes of blindness worldwide. One of the recent health concerns is the increasing incidence of corneal ulcers associated with contact lens user especially if the users fail to follow specific instruction in using their contact lenses. Risk factors associated with increased risk of contact lens related corneal ulcers are: overnight wear, long duration of continuous wear, lower socio-economic classes, smoking, dry eye and poor hygiene. Th...

  7. Modal analysis of an ECC duct for APR+ reactor barrel

    International Nuclear Information System (INIS)

    Kang, H.S.; Lee, K.H.; Kwon, T.S.

    2011-01-01

    Advanced Power Reactor Plus (APR+) provides four Direct Vessel Injection (DVI) ducts on the reactor barrel to enhance the performance of Emergency Core Cooling System (ECCS). Several studies on safety analysis have verified the excellent performance of the DVI duct. In this study, from the viewpoint of mechanical integrity, modal analyses of two full-scaled DVI ducts have been presented; both numerical analysis and modal tests have been performed in air and water. It was found that the numerical simulation and modal test coincide with each other. The DVI duct is a thin shell of 5 mm thickness, so that harmonic responses to RCP blade passing frequencies should be checked. The dominant passing frequencies are known to be 20, 40, 60, 120 and 240 Hz. In addition, an interesting thing in this study is that added mass effect by coolant seems to be so significant that the natural frequency of the ducts under water could be considerably low as compared with those in air; the natural frequency under water is 60 % lower than that in air. (author)

  8. High Stimulus-Related Information in Barrel Cortex Inhibitory Interneurons.

    Directory of Open Access Journals (Sweden)

    Vicente Reyes-Puerta

    2015-06-01

    Full Text Available The manner in which populations of inhibitory (INH and excitatory (EXC neocortical neurons collectively encode stimulus-related information is a fundamental, yet still unresolved question. Here we address this question by simultaneously recording with large-scale multi-electrode arrays (of up to 128 channels the activity of cell ensembles (of up to 74 neurons distributed along all layers of 3-4 neighboring cortical columns in the anesthetized adult rat somatosensory barrel cortex in vivo. Using two different whisker stimulus modalities (location and frequency we show that individual INH neurons--classified as such according to their distinct extracellular spike waveforms--discriminate better between restricted sets of stimuli (≤6 stimulus classes than EXC neurons in granular and infra-granular layers. We also demonstrate that ensembles of INH cells jointly provide as much information about such stimuli as comparable ensembles containing the ~20% most informative EXC neurons, however presenting less information redundancy - a result which was consistent when applying both theoretical information measurements and linear discriminant analysis classifiers. These results suggest that a consortium of INH neurons dominates the information conveyed to the neocortical network, thereby efficiently processing incoming sensory activity. This conclusion extends our view on the role of the inhibitory system to orchestrate cortical activity.

  9. Barrel Toroid fully charged to nominal field, and it works!

    CERN Multimedia

    Herman ten Kate

    After a few weeks of testing up to intermediate currents, finally, on Thursday evening November 9, the current in the Barrel Toroid was pushed up to its nominal value of 20500 A and even 500 A beyond this value to prove that we have some margin. It went surprisingly well. Of course, the 8 coils forming the toroid were already tested individually at the surface but still, some surprise may have come from those parts added to the toroid in the cavern for the first time like the 8 cryoring sections linking the coils as well as the valve box at the bottom in sector 13 regulating the helium flow or the current lead cryostat on the top in sector 5. No training quenches, nothing to worry about, and the test was concluded with a fast dump triggered at 00:40 in the very early morning of November 10. (left) The toroid current during the evening and night of November 9. (right) The test crew oscillated between fear and hope while looking at the control panels as the current approached 21kA. Big relief was in the...

  10. Cryogenic Characteristics of the ATLAS Barrel Toroid Superconducting Magnet

    CERN Document Server

    Pengo, R; Delruelle, N; Pezzetti, M; Pirotte, O; Passardi, Giorgio; Dudarev, A; ten Kate, H

    2008-01-01

    ATLAS, one of the experiments of the LHC accelerator under commissioning at CERN, is equipped with a large superconducting magnet the Barrel Toroid (BT) that has been tested at nominal current (20500 A). The BT is composed of eight race-track superconducting coils (each one weights about 45 tons) forming the biggest air core toroidal magnet ever built. By means of a large throughput centrifugal pump, a forced flow (about 10 liter/second at 4.5 K) provides the indirect cooling of the coils in parallel. The paper describes the results of the measurements carried out on the complete cryogenic system assembled in the ATLAS cavern situated 100 m below the ground level. The measurements include, among other ones, the static heat loads, i.e., with no or constant current in the magnet, and the dynamic ones, since additional heat losses are produced, during the current ramp-up or slow dump, by eddy currents induced on the coil casing.

  11. Energy Resolution of the Barrel of the CMS Electromagnetic Calorimeter

    CERN Document Server

    Adzic, Petar; Almeida, Carlos; Almeida, Nuno; Anagnostou, Georgios; Anfreville, Marc; Anicin, Ivan; Antunovic, Zeljko; Auffray, Etiennette; Baccaro, Stefania; Baffioni, Stephanie; Baillon, Paul; Barney, David; Barone, Luciano; Barrillon, Pierre; Bartoloni, Alessandro; Beauceron, Stephanie; Beaudette, Florian; Bell, Ken W; Benetta, Robert; Bercher, Michel; Berthon, Ursula; Betev, Botjo; Beuselinck, Raymond; Bhardwaj, Ashutosh; Bialas, Wojciech; Biino, Cristina; Bimbot, Stephane; Blaha, Jan; Bloch, Philippe; Blyth, Simon; Bordalo, Paula; Bornheim, Adolf; Bourotte, Jean; Britton, David; Brown, Robert M; Brunelière, Renaud; Busson, Philippe; Camporesi, Tiziano; Cartiglia, Nicolo; Cavallari, Francesca; Cerutti, Muriel; Chamont, David; Chang, Paoti; Chang, You-Hao; Charlot, Claude; Chatterji, Sudeep; Chen, E Augustine; Chipaux, Rémi; Choudhary, Brajesh C; Cockerill, David J A; Collard, Caroline; Combaret, Christophe; Cossutti, Fabio; Da Silva, J C; Dafinei, Ioan; Daskalakis, Georgios; Davatz, Giovanna; Decotigny, David; De Min, Alberto; Deiters, Konrad; Dejardin, Marc; Del Re, Daniele; Della Negra, Rodolphe; Della Ricca, Giuseppe; Depasse, Pierre; Descamp, J; Dewhirst, Guy; Dhawan, Satish; Diemoz, Marcella; Dissertori, Günther; Dittmar, Michael; Djambazov, Lubomir; Dobrzynski, Ludwik; Drndarevic, Snezana; Dupanloup, Michel; Dzelalija, Mile; Ehlers, Jan; El-Mamouni, H; Peisert, Anna; Evangelou, Ioannis; Fabbro, Bernard; Faure, Jean-Louis; Fay, Jean; Ferri, Federico; Flower, Paul S; Franzoni, Giovanni; Funk, Wolfgang; Gaillac, Anne-Marie; Gargiulo, Corrado; Gascon-Shotkin, S; Geerebaert, Yannick; Gentit, François-Xavier; Ghezzi, Alessio; Gilly, Jean; Giolo-Nicollerat, Anne-Sylvie; Givernaud, Alain; Gninenko, Sergei; Go, Apollo; Godinovic, Nikola; Golubev, Nikolai; Golutvin, Igor; Gómez-Reino, Robert; Govoni, Pietro; Grahl, James; Gras, Philippe; Greenhalgh, Justin; Guillaud, Jean-Paul; Haguenauer, Maurice; Hamel De Montechenault, G; Hansen, Magnus; Heath, Helen F; Hill, Jack; Hobson, Peter R; Holmes, Daniel; Holzner, André; Hou, George Wei-Shu; Ille, Bernard; Ingram, Quentin; Jain, Adarsh; Jarry, Patrick; Jauffret, C; Jha, Manoj; Karar, M A; Kataria, Sushil Kumar; Katchanov, V A; Kennedy, Bruce W; Kloukinas, Kostas; Kokkas, Panagiotis; Korjik, M; Krasnikov, Nikolai; Krpic, Dragomir; Kyriakis, Aristotelis; Lebeau, Michel; Lecomte, Pierre; Lecoq, Paul; Lemaire, Marie-Claude; Lethuillier, Morgan; Lin, Willis; Lintern, A L; Lister, Alison; Litvin, V; Locci, Elizabeth; Lodge, Anthony B; Longo, Egidio; Loukas, Demetrios; Luckey, D; Lustermann, Werner; Lynch, Clare; MacKay, Catherine Kirsty; Malberti, Martina; Maletic, Dimitrije; Mandjavidze, Irakli; Manthos, Nikolaos; Markou, Athanasios; Mathez, Hervé; Mathieu, Antoine; Matveev, Viktor; Maurelli, Georges; Menichetti, Ezio; Meridiani, Paolo; Milenovic, Predrag; Milleret, Gérard; Miné, Philippe; Mur, Michel; Musienko, Yuri; Nardulli, Alessandro; Nash, Jordan; Neal, Homer; Nédélec, Patrick; Negri, Pietro; Nessi-Tedaldi, Francesca; Newman, Harvey B; Nikitenko, Alexander; Obertino, Maria Margherita; Ofierzynski, Radoslaw Adrian; Organtini, Giovanni; Paganini, Pascal; Paganoni, Marco; Papadopoulos, Ioannis; Paramatti, Riccardo; Pastrone, Nadia; Pauss, Felicitas; Puljak, Ivica; Pullia, Antonino; Puzovic, Jovan; Ragazzi, Stefano; Ramos, Sergio; Rahatlou, Shahram; Rander, John; Ranjan, Kirti; Ravat, Olivier; Raymond, M; Razis, Panos A; Redaelli, Nicola; Renker, Dieter; Reucroft, Steve; Reymond, Jean-Marc; Reynaud, Michel; Reynaud, Serge; Romanteau, Thierry; Rondeaux, Françoise; Rosowsky, André; Rovelli, Chiara; Rumerio, Paolo; Rusack, Roger; Rusakov, Sergey V; Ryan, Matthew John; Rykaczewski, Hans; Sakhelashvili, Tariel; Salerno, Roberto; Santos, Marcelino; Seez, Christopher; Semeniouk, Igor; Sharif, Omar; Sharp, Peter; Shepherd-Themistocleous, Claire; Shevchenko, Sergey; Shivpuri, Ram Krishen; Sidiropoulos, Georgios; Sillou, Daniel; Singovsky, Alexander; Sirois, Y; Sirunyan, Albert M; Smith, Brian; Smith, Vincent J; Sproston, Martin; Suter, Henry; Swain, John; Tabarelli de Fatis, Tommaso; Takahashi, Maiko; Tapper, Robert J; Tcheremoukhine, Alexandre; Teixeira, Isabel; Teixeira, Joao Paulo; Teller, Olivier; Timlin, Claire; Triantis, F A; Troshin, Sergey; Tyurin, Nikolay; Ueno, Koji; Uzunian, Andrey; Varela, Joao; Vaz-Cardoso, N; Verrecchia, Patrice; Vichoudis, Paschalis; Vigano, S; Viertel, Gert; Virdee, Tejinder; Vlassov, E; Wang, Minzu; Weinstein, Alan; Williams, Jennifer C; Yaselli, Ignacio; Zabi, Alexandre; Zamiatin, Nikolai; Zelepoukine, Serguei; Zeller, Michael E; Zhang, Lin; Zhang, Jia-Wen; Zhang, Yawei; Zhu, Kejun; Zhu, Ren-Yuan

    2007-01-01

    The energy resolution of the barrel part of the CMS Electromagnetic Calorimeter has been studied using electrons of 20 to 250 GeV in a test beam. The incident electron's energy was reconstructed by summing the energy measured in arrays of 3x3 or 5x5 channels. There was no significant amount of correlated noise observed within these arrays. For electrons incident at the centre of the studied 3x3 arrays of crystals, the mean stochastic term was measured to be 2.8% and the mean constant term to be 0.3%. The amount of the incident electron's energy which is contained within the array depends on its position of incidence. The variation of the containment with position is corrected for using the distribution of the measured energy within the array. For uniform illumination of a crystal with 120 GeV electrons a resolution of 0.5% was achieved. The energy resolution meets the design goal for the detector.

  12. Geometry optimization of a barrel silicon pixelated tracker

    Science.gov (United States)

    Liu, Qing-Yuan; Wang, Meng; Winter, Marc

    2017-08-01

    We have studied optimization of the design of a barrel-shaped pixelated tracker for given spatial boundaries. The optimization includes choice of number of layers and layer spacing. Focusing on tracking performance only, momentum resolution is chosen as the figure of merit. The layer spacing is studied based on Gluckstern’s method and a numerical geometry scan of all possible tracker layouts. A formula to give the optimal geometry for curvature measurement is derived in the case of negligible multiple scattering to deal with trajectories of very high momentum particles. The result is validated by a numerical scan method, which could also be implemented with any track fitting algorithm involving material effects, to search for the optimal layer spacing and to determine the total number of layers for the momentum range of interest under the same magnetic field. The geometry optimization of an inner silicon pixel tracker proposed for BESIII is also studied by using a numerical scan and these results are compared with Geant4-based simulations. Supported by National Natural Science Foundation of China (U1232202)

  13. Prototype radiators of a barrel DIRC for the PANDA experiment

    International Nuclear Information System (INIS)

    Hohler, Roland

    2011-01-01

    The antiproton experiment PANDA at the future accelerator facility FAIR will among others be able to measure charmonium states with a hitherto unreached accuracy. In order to reach this goal a very good particle-identification ability is required. A good separation between pions and kaons is reached by application of a Cherenkov detector. The power of a DIRC depends on the quality of its radiator. In order to be able to specify the quality of the radiator rods, in the framework of this thesis an optical measuring apparature was developed. This setup allows to measure the transmission as well as the surface roughness of the rods. Several radiator rods of synthetic quartz glass and acryl glass were studied. The measurement accuracy at high-quality rods lies for the transmission measurement at about 1 % and for the roughness at 1-2 Aa. The measurement result at different wavelengths exhibit a good agreement with the scalar scattering theory, which describes the connection between reflection coefficient and roughness. At a beam time at the GSI with a 2 GeV proton beam a first prototype for the barrel DIRC with a rod of synthetical quartz glass as radiator was tested. By variation of the incident angle and the position of the proton beam on the radiator Cherenkov rings could be uniquely detected. Additionally the Cherenkov angle and the single-photon resolution was determined in good agreement with the expected and the simulation.

  14. Double barreled wet colostomy: initial experience and literature review.

    Science.gov (United States)

    Salgado-Cruz, Luis; Espin-Basany, Eloy; Vallribera-Valls, Francesc; Sanchez-Garcia, Jose; Jimenez-Gomez, Luis Miguel; Marti-Gallostra, Marc; Garza-Maldonado, Ana

    2014-01-01

    Pelvic exenteration and multivisceral resection in colorectal have been described as a curative and palliative intervention. Urinary tract reconstruction in a pelvic exenteration is achieved in most cases with an ileal conduit of Bricker, although different urinary reservoirs have been described. A retrospective and observational study of six patients who underwent a pelvic exenteration and urinary tract reconstruction with a double barreled wet colostomy (DBWC) was done, describing the preoperative diagnosis, the indication for the pelvic exenteration, the complications associated with the procedure, and the followup in a period of 5 years. A literature review of the case series reported of the technique was performed. Six patients had a urinary tract reconstruction with the DBWC technique, 5 male patients and one female patient. Age range was from 20 to 77 years, with a medium age 53.6 years. The most frequent complication presented was a pelvic abscess in 3 patients (42.85%); all complications could be resolved with a conservative treatment. In the group of our patients with pelvic exenteration and urinary tract reconstruction with a DBWC, it is a safe procedure and well tolerated by the patients, and most of the complications can be resolved with conservative treatment.

  15. Double Barreled Wet Colostomy: Initial Experience and Literature Review

    Directory of Open Access Journals (Sweden)

    Luis Salgado-Cruz

    2014-01-01

    Full Text Available Background. Pelvic exenteration and multivisceral resection in colorectal have been described as a curative and palliative intervention. Urinary tract reconstruction in a pelvic exenteration is achieved in most cases with an ileal conduit of Bricker, although different urinary reservoirs have been described. Methods. A retrospective and observational study of six patients who underwent a pelvic exenteration and urinary tract reconstruction with a double barreled wet colostomy (DBWC was done, describing the preoperative diagnosis, the indication for the pelvic exenteration, the complications associated with the procedure, and the followup in a period of 5 years. A literature review of the case series reported of the technique was performed. Results. Six patients had a urinary tract reconstruction with the DBWC technique, 5 male patients and one female patient. Age range was from 20 to 77 years, with a medium age 53.6 years. The most frequent complication presented was a pelvic abscess in 3 patients (42.85%; all complications could be resolved with a conservative treatment. Conclusion. In the group of our patients with pelvic exenteration and urinary tract reconstruction with a DBWC, it is a safe procedure and well tolerated by the patients, and most of the complications can be resolved with conservative treatment.

  16. Charged Pion Energy Reconstruction in the ATLAS Barrel Calorimeter

    CERN Document Server

    Bosman, Martine; Nessi, Marzio

    1999-01-01

    Intrinsic performance of the ATLAS calorimeters in the barrel region with respect to charged pions was studied. For this the following simulated data were used: pion energy scans ($E = 20, 50, 200, 400$ and $1000$ GeV) at two pseudo-rapidity points ($eta = 0.3$ and $1.3$) and pseudo-rapidity scans ($-0.2 < eta < 1.8$) with pions of constant transverse energy ($E_T = 20$ and $50$ GeV). For pion energy reconstruction the benchmark approach was used. Performance was estimated for cases, when energy and rapidity dependent and independent calibration parameters were applied. The best results were obtained with energy and rapidity dependent parameters. Studies done for pions enabled optimization of the cone size and of the cut to obtain the best energy resolution. Energy dependence of the resolution can be parameterized as: $(50pm4)%/sqrt{E} oplus (3.4pm0.3)% oplus 1.0/E$ at $eta = 0.3$ and $(68pm8)%/sqrt{E} oplus (3.0pm0.7)% oplus 1.5/E$ at $eta = 1.3$. Larger constant term at $eta=0.3$ can be explained by l...

  17. A course in lens design

    CERN Document Server

    Velzel, Chris

    2014-01-01

    A Course in Lens Design is an instruction in the design of image-forming optical systems. It teaches how a satisfactory design can be obtained in a straightforward way. Theory is limited to a minimum, and used to support the practical design work. The book introduces geometrical optics, optical instruments and aberrations. It gives a description of the process of lens design and of the strategies used in this process. Half of its content is devoted to the design of sixteen types of lenses, described in detail from beginning to end. This book is different from most other books on lens design because it stresses the importance of the initial phases of the design process: (paraxial) lay-out and (thin-lens) pre-design. The argument for this change of accent is that in these phases much information can be obtained about the properties of the lens to be designed. This information can be used in later phases of the design. This makes A Course in Lens Design a useful self-study book, and a suitable basis for an intro...

  18. Gabor lens theory

    International Nuclear Information System (INIS)

    Irani, A.A.

    1978-01-01

    The principle of using the space charge of an electron cloud to focus ion beams was first proposed by Gabor. Electrons are to be confined radially by means of an axial magnetic field B/sub z/ and axially by means of externally applied electric fields E/sub z/. An ion beam of charge density n/sub i/ much less than n/sub e/, the electron charge density can then be focused by the radial electric field set up by the electron cloud. The case considered here is that of a hollow cylindrical conductor charged to a potential +V with grounded rings on either side to set up the axial E/sub z/ field. A solenoid wound around the central conductor supplies the B/sub z/ field. Theoretical calculations are carried out for n/sub e/ maximum as a function of B/sub z/ due to radial confinement and V due to axial confinement and the focal length of the Gabor Lens is calculated

  19. Research on the surface of a nonspherical lens with photosensitive colophony

    Science.gov (United States)

    Zhao, Fu; Wang, Ping; Gong, Yanjue; Xin, Hongbing; Meng, Chunling; Zhu, Hui

    2009-05-01

    This paper does research on the shrinkage deformation caused by photosensitive colophony solidification in manufacturing aspheric surface lens. With Finite Element Analysis, Orthogonal Experiment, and BP Neural Network methods, the relationship between the shrinkage deformation of aspheric lens and structure parameters is built up. With the mathematic model, the shrinkage compensable software for aspheric lens manufacturing is compiled to find out the original shape after the shrinkage deformed shape is given. As a result, the mould surface curve is easily obtained in accordance with the given aspheric lens shape.

  20. Beta 2-adrenergic receptors are colocalized and coregulated with whisker barrels in rat somatosensory cortex

    Energy Technology Data Exchange (ETDEWEB)

    Vos, P.; Kaufmann, D.; Hand, P.J.; Wolfe, B.B. (Univ. of Pennsylvania, Philadelphia (USA))

    1990-07-01

    Autoradiography has been used to visualize independently the subtypes of beta-adrenergic receptors in rat somatosensory cortex. Beta 2-adrenergic receptors, but not beta 1-adrenergic receptors colocalize with whisker barrels in this tissue. Thus, each whisker sends a specific multisynaptic pathway to the somatosensory cortex that can be histochemically visualized and only one subtype of beta-adrenergic receptor is specifically associated with this cortical representation. Additionally, neonatal lesion of any or all of the whisker follicles results in loss of the corresponding barrel(s) as shown by histochemical markers. This loss is paralleled by a similar loss in the organization of beta 2-adrenergic receptors in the somatosensory cortex. Other results indicate that these beta 2-adrenergic receptors are not involved in moment-to-moment signal transmission in this pathway and, additionally, are not involved in a gross way in the development of whisker-barrel array.

  1. A Front-End Readout Architecture for the CMS Barrel Muon Detector: A Feasibility Study

    International Nuclear Information System (INIS)

    Aguayo, P.; Alberdi, J.; Barcala, J.M.; Marin, J.; Molinero, A.; Navarrete, J.; Pablos, J.L. de; Romero, L.; Willmot, C.

    1995-01-01

    A feasibility study of a possible architecture for the CMS barrel muon detector readout electronics is presented. some aspects of system reliability are discussed. Values for the required FIFO's to store data during the first level trigger latency are given

  2. Astrocytes control GABAergic inhibition of neurons in the mouse barrel cortex.

    Science.gov (United States)

    Benedetti, B; Matyash, V; Kettenmann, H

    2011-03-01

    Astrocytes in the barrel cortex respond with a transient Ca2+ increase to neuronal stimulation and this response is restricted to the stimulated barrel field. In the present study we suppressed the astrocyte response by dialysing these cells with the Ca2+ chelator BAPTA. Electrical stimulation triggered a depolarization in stellate or pyramidal ‘regular spiking' neurons from cortex layer 4 and 2/3 and this response was augmented in amplitude and duration after astrocytes were dialysed with BAPTA. Combined blockade of GABAA and GABAB receptors mimicked the effect of BAPTA dialysis, while glutamate receptor blockers had no effect. Moreover, the frequency of spontaneous postsynaptic currents was increased after BAPTA dialysis. Outside the range of BAPTA dialysis astrocytes responded with a Ca2+ increase, but in contrast to control, the response was no longer restricted to one barrel field. Our findings indicate that astrocytes control neuronal inhibition in the barrel cortex.

  3. Astrocytes control GABAergic inhibition of neurons in the mouse barrel cortex

    Science.gov (United States)

    Benedetti, B; Matyash, V; Kettenmann, H

    2011-01-01

    Astrocytes in the barrel cortex respond with a transient Ca2+ increase to neuronal stimulation and this response is restricted to the stimulated barrel field. In the present study we suppressed the astrocyte response by dialysing these cells with the Ca2+ chelator BAPTA. Electrical stimulation triggered a depolarization in stellate or pyramidal ‘regular spiking’ neurons from cortex layer 4 and 2/3 and this response was augmented in amplitude and duration after astrocytes were dialysed with BAPTA. Combined blockade of GABAA and GABAB receptors mimicked the effect of BAPTA dialysis, while glutamate receptor blockers had no effect. Moreover, the frequency of spontaneous postsynaptic currents was increased after BAPTA dialysis. Outside the range of BAPTA dialysis astrocytes responded with a Ca2+ increase, but in contrast to control, the response was no longer restricted to one barrel field. Our findings indicate that astrocytes control neuronal inhibition in the barrel cortex. PMID:21224221

  4. Dynamics and Stability of Stepped Gun-Barrels with Moving Bullets

    Directory of Open Access Journals (Sweden)

    Mohammad Tawfik

    2008-01-01

    reintroduced using simple eigenvalue analysis of a finite element model. The eigenvalues of the beam change with the mass, speed, and position of the projectile, thus, the eigenvalues are evaluated for the system with different speeds and masses at different positions until the lowest eigenvalue reaches zero indicating the instability occurrence. Then a map for the stability region may be obtained for different boundary conditions. Then the dynamics of the beam will be investigated using the Newmark algorithm at different values of speed and mass ratios. Finally, the effect of using stepped barrels on the stability and the dynamics is going to be investigated. It is concluded that the technique used to predict the stability boundaries is simple, accurate, and reliable, the mass of the barrel on the dynamics of the problem cannot be ignored, and that using the stepped barrels, with small increase in the diameter, enhances the stability and the dynamics of the barrel.

  5. External barrel temperature of a small bore olympic rifle and shooting precision.

    Science.gov (United States)

    Gladyszewska, B; Baranowski, P; Mazurek, W; Wozniak, J; Gladyszewski, G

    2013-03-01

    Investigations on changes in a rifle's barrel temperature during shooting in a rhythm typical for practitioners of Olympic shooting sports are presented. Walther KK300 (cal. 5.6 mm), a typical rifle often used in Olympic competitions, R50 RWS ammunition and a high speed thermographic camera were used in the study. Altair version 5 software was used to process thermal images and a stationary wavelet transform was applied to denoise signals for all the studied points. It was found that the temperature of the rifle barrel does not exceed 0.3°C after one shot whereas the total temperature increase does not exceed 5°C after taking 40 shots and does not affect the position of the hitting point on a target. In fact, contrary to popular belief, the so-called "warming shots" are not done for barrel heating but for cleaning of remnants in the barrel.

  6. Diffraction enhanced X-ray imaging of mammals crystalline lens

    Energy Technology Data Exchange (ETDEWEB)

    Antunes, A. [Departamento de Fisica Aplicada, USP, CP 66318, 05315-970 Sao Paulo, SP (Brazil)]. E-mail: antunes@if.usp.br; Hoennicke, M.G. [LORXI, Departamento de Fisica, Universidade Federal do Parana, Curitiba (Brazil); Safatle, A.M.V. [Faculdade de Medicina Veterinaria e Zootecnia, USP, 05508-900 Sao Paulo, SP (Brazil); Cusatis, C. [LORXI, Departamento de Fisica, Universidade Federal do Parana, Curitiba (Brazil); Moraes Barros, P.S. [Faculdade de Medicina Veterinaria e Zootecnia, USP, 05508-900 Sao Paulo, SP (Brazil); Morelhao, S.L. [Departamento de Fisica Aplicada, USP, CP 66318, 05315-970 Sao Paulo, SP (Brazil)

    2005-08-15

    Crystalline lenses are transparent biological materials where the organization of the lens fibers can also be affected by changes at molecular level, and therefore the structure and morphology of the tissue can be correlated to the loss of transparency of the lens. In this work, internal structure of mammal lenses regarding the long-range ordering of the fibers are investigated by diffraction enhanced X-ray imaging (DEI) radiography. Moreover, DEI and absorption X-ray synchrotron radiographs for healthy and cataractous crystalline lenses are compared. Significant differences in healthy and cataractous crystalline lenses are observed.

  7. Diffraction enhanced X-ray imaging of mammals crystalline lens

    International Nuclear Information System (INIS)

    Antunes, A.; Hoennicke, M.G.; Safatle, A.M.V.; Cusatis, C.; Moraes Barros, P.S.; Morelhao, S.L.

    2005-01-01

    Crystalline lenses are transparent biological materials where the organization of the lens fibers can also be affected by changes at molecular level, and therefore the structure and morphology of the tissue can be correlated to the loss of transparency of the lens. In this work, internal structure of mammal lenses regarding the long-range ordering of the fibers are investigated by diffraction enhanced X-ray imaging (DEI) radiography. Moreover, DEI and absorption X-ray synchrotron radiographs for healthy and cataractous crystalline lenses are compared. Significant differences in healthy and cataractous crystalline lenses are observed

  8. Electron beam irradiations of polypropylene syringe barrels and the resulting physical and chemical property changes

    Science.gov (United States)

    Abraham, Ann C.; Czayka, M. A.; Fisch, M. R.

    2010-01-01

    Mechanical, thermal, chemical decomposition and electron spin resonance (ESR) methods were used to study electron beam irradiated polypropylene syringe barrels that were irradiated to a total fractionated dose of 0, 20, 40, 60, and 80 kGy (in steps of 20 kGy). Dose mapping was conducted to determine dose to and through the syringe barrel. Analysis of these data indicated that degradation of the polypropylene syringes increased with an increase in electron beam irradiation.

  9. Electrical Discharge Machining (EDM) Gun Barrel Bore and Rifling Feasibility Study

    Science.gov (United States)

    1974-09-01

    shaft speed and elastic instability of the electrode carrier. An electrode wobble would have the effect of producing a barrel that would have a bulge ...the degree of least stiffness. The bulge in the barrels was not discovered until rubber replicas of the bore were reproduced. This was believed to...steffurther tUfill ofV^ the CUtting ^^tion. either the size of the capacitor ^n or PUlSe iS then rclated ^ tude of the current pulsed rated

  10. Energy calibration of the barrel calorimeter of the CMD-3 detector

    International Nuclear Information System (INIS)

    Anisenkov, A.V.; Aulchenko, V.M.; Bashtovoy, N.S.; Bondar, A.E.; Grebenuk, A.A.; Epifanov, D.A.; Epshteyn, L.B.; Erofeev, A.L.; Kovalenko, O.A.; Kozyrev, A.N.; Kuzmin, A.S.; Mikhailov, K.Yu.; Logashenko, I.B.; Razuvaev, G.P.; Ruban, A.A.; Shebalin, V.E.; Shwartz, B.A.; Talyshev, A.A.; Titov, V.M.; Yudin, Yu.V.

    2017-01-01

    The VEPP-2000 e + e − collider has been operated in the Budker Institute of Nuclear Physics since 2010. Experiments are carried out with two detectors CMD-3 and SND. The calorimetry at the CMD-3 detector is based on three subsystems, two coaxial barrel calorimeters—Liquid Xenon calorimeter and crystal CsI calorimeter, and end cap calorimeter with BGO crystals. This paper describes the procedures of the energy calibration of the combined barrel calorimeter of the CMD-3 detector.

  11. Research on vibration characteristics of gun barrel based on contact model

    Science.gov (United States)

    Zhao, Yang; Zhou, Qizheng; Yue, Pengfei

    2017-04-01

    In order to study vibration characteristics of the gun barrel under the action of moving projectile, the gun barrel is simplified to cross sectional cantilever beam such as Euler. Considering contact conditions of inertia effect and projectile with the gun barrel, the equation of lateral vibration of the gun barrel is established under the projectile-gun coupling effect; the modal analysis method is used to give the analytic solutions of equation series. The effect of the motion parameters the projectile on the vibration of gun barrel is discussed, and characteristics of vibration of gun barrel are further studied under two conditions of repeating and projectile with mass eccentricity. The research results show that reasonable control of the acceleration of the projectile in the gun bore, and reduction of projectile mass eccentricity can help reduce the muzzle vibration at the gun firing. The research results can provide reference for overall design of the gun, and the modeling and analysis method used in the paper can be promoted for the solution of vibration of other related projects under the moving excitation.

  12. Evolutions of volatile sulfur compounds of Cabernet Sauvignon wines during aging in different oak barrels.

    Science.gov (United States)

    Ye, Dong-Qing; Zheng, Xiao-Tian; Xu, Xiao-Qing; Wang, Yun-He; Duan, Chang-Qing; Liu, Yan-Lin

    2016-07-01

    The evolution of volatile sulfur compounds (VSCs) in Cabernet Sauvignon wines from seven regions of China during maturation in oak barrels was investigated. The barrels were made of different wood grains (fine and medium) and toasting levels (light and medium). Twelve VSCs were quantified by GC/FPD, with dimethyl sulfide (DMS) and methionol exceeding their sensory thresholds. Most VSCs tended to decline during the aging, while DMS was found to increase. After one year aging, the levels of DMS, 2-methyltetrahy-drothiophen-3-one and sulfur-containing esters were lower in the wines aged in oak barrels than in stainless steel tanks. The wood grain and toasting level of oak barrels significantly influenced the concentration of S-methyl thioacetate and 2-methyltetrahy-drothiophen-3-one. This study reported the evolution of VSCs in wines during oak barrel aging for the first time and evaluated the influence of barrel types, which would provide wine-makers with references in making proposals about wine aging. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. The serotonin reuptake inhibitor citalopram suppresses activity in the neonatal rat barrel cortex in vivo.

    Science.gov (United States)

    Akhmetshina, Dinara; Zakharov, Andrei; Vinokurova, Daria; Nasretdinov, Azat; Valeeva, Guzel; Khazipov, Roustem

    2016-06-01

    Inhibition of serotonin uptake, which causes an increase in extracellular serotonin levels, disrupts the development of thalamocortical barrel maps in neonatal rodents. Previous in vitro studies have suggested that the disruptive effect of excessive serotonin on barrel map formation involves a depression at thalamocortical synapses. However, the effects of serotonin uptake inhibitors on the early thalamocortical activity patterns in the developing barrel cortex in vivo remain largely unknown. Here, using extracellular recordings of the local field potentials and multiple unit activity (MUA) we explored the effects of the selective serotonin reuptake inhibitor (SSRI) citalopram (10-20mg/kg, intraperitoneally) on sensory evoked activity in the barrel cortex of neonatal (postnatal days P2-5) rats in vivo. We show that administration of citalopram suppresses the amplitude and prolongs the delay of the sensory evoked potentials, reduces the power and frequency of the early gamma oscillations, and suppresses sensory evoked and spontaneous neuronal firing. In the adolescent P21-29 animals, citalopram affected neither sensory evoked nor spontaneous activity in barrel cortex. We suggest that suppression of the early thalamocortical activity patterns contributes to the disruption of the barrel map development caused by SSRIs and other conditions elevating extracellular serotonin levels. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Functional diversity of supragranular GABAergic neurons in the barrel cortex

    Directory of Open Access Journals (Sweden)

    Luc J Gentet

    2012-08-01

    Full Text Available Although the neocortex forms a distributed system comprised of several functional areas, its vertical columnar organization is largely conserved across areas and species, suggesting the existence of a canonical neocortical microcircuit. In order to elucidate the principles governing the organization of such a cortical diagram, a detailed understanding of the dynamics binding different types of cortical neurons into a coherent algorithm is essential. Within this complex circuitry, GABAergic interneurons, while forming approximately only 15-20% of all cortical neurons, appear critical in maintaining a dynamic balance between excitation and inhibition. Despite their importance, cortical GABAergic neurons have not been extensively studied in vivo and their precise role in shaping the local microcircuit sensory response still remains to be determined. Their paucity, combined with their molecular, anatomical and physiological diversity, has made it difficult to even establish a consensual nomenclature.However, recent technological advances in microscopy and mouse genetics have fostered a renewed interest in neocortical interneurons by putting them within visible reach of experimenters. The anatomically well-defined whisker-to-barrel pathway of the rodent is particularly amenable to studies attempting to link cortical circuit dynamics to behavior. To each whisker corresponds a discrete cortical unit equivalent to a single column, specialized in the encoding and processing of the sensory information it receives. In this review, we will focus on the functional role that each subtype of supragranular GABAergic neuron embedded within such a single neocortical unit may play in shaping the dynamics of the local circuit during somatosensory integration.

  15. Nanoceria have no genotoxic effect on human lens epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Pierscionek, Barbara K; Yasseen, Akeel A [School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA (United Kingdom); Li, Yuebin; Schachar, Ronald A; Chen, Wei [Department of Physics, University of Texas at Arlington, Arlington, TX 76019 (United States); Colhoun, Liza M, E-mail: b.pierscionek@ulster.ac.uk, E-mail: weichen@uta.edu [Centre for Vision and Vascular Sciences, School of Medicine, Dentistry and Biomedical Sciences, Queen' s University Belfast, Grosvenor Road, Belfast, BT12 6BA (United Kingdom)

    2010-01-22

    There are no treatments for reversing or halting cataract, a disease of the structural proteins in the eye lens, that has associations with other age-related degenerative conditions such as Alzheimer's disease. The incidence of cataract and associated conditions is increasing as the average age of the population rises. Protein folding diseases are difficult to assess in vivo as proteins and their age-related changes are assessed after extraction. Nanotechnology can be used to investigate protein changes in the intact lens as well as for a potential means of drug delivery. Nanoparticles, such as cerium oxide (CeO{sub 2}) which have antioxidant properties, may even be used as a means of treating cataract directly. Prior to use in treatments, nanoparticle genotoxicity must be tested to assess the extent of any DNA or chromosomal damage. Sister chromatid exchanges were measured and DNA damage investigated using the alkaline COMET assay on cultured human lens epithelial cells, exposed to 5 and 10 {mu}g ml{sup -1} of CeO{sub 2} nanoparticles (nanoceria). Nanoceria at these dosages did not cause any DNA damage or significant increases in the number of sister chromatid exchanges. The absence of genotoxic effects on lens cells suggests that nanoceria, in the doses and exposures tested in this study, are not deleterious to the eye lens and have the potential for use in studying structural alterations, in developing non-surgical cataract treatments and in investigating other protein folding diseases.

  16. Sensory deprivation differentially impacts the dendritic development of pyramidal versus non-pyramidal neurons in layer 6 of mouse barrel cortex.

    Science.gov (United States)

    Chen, Chia-Chien; Tam, Danny; Brumberg, Joshua C

    2012-04-01

    Early postnatal sensory experience can have profound impacts on the structure and function of cortical circuits affecting behavior. Using the mouse whisker-to-barrel system we chronically deprived animals of normal sensory experience by bilaterally trimming their whiskers every other day from birth for the first postnatal month. Brain tissue was then processed for Golgi staining and neurons in layer 6 of barrel cortex were reconstructed in three dimensions. Dendritic and somatic parameters were compared between sensory-deprived and normal sensory experience groups. Results demonstrated that layer 6 non-pyramidal neurons in the chronically deprived group showed an expansion of their dendritic arbors. The pyramidal cells responded to sensory deprivation with increased somatic size and basilar dendritic arborization but overall decreased apical dendritic parameters. In sum, sensory deprivation impacted on the neuronal architecture of pyramidal and non-pyramidal neurons in layer 6, which may provide a substrate for observed physiological and behavioral changes resulting from whisker trimming.

  17. [Contact lens care and maintenance].

    Science.gov (United States)

    Bloise, L

    2017-04-01

    All contact lenses with replacement schedules longer than daily must be maintained. At each step of their use, the lenses may be contaminated. Contact lens solutions perform the essential functions of cleaning, decontaminating and preserving the lenses to prevent infectious problems and improve wearing comfort. Contact lens contamination essentially comes from hands, cleaning solutions, cases, water and the environment. The pathogenic microorganisms are mainly Gram-negative bacteria, fungi and amoebae. Contact lens deposits may or may not have an organic origin. Their presence increases the risk of infection because they serve as a nutrient matrix for microbes, and they are responsible for wearing discomfort. Contact lens solutions differ in their composition, their mechanism of action and the concentration of the various agents. To prescribe the best lens care system to each wearer and for each material, it is necessary to be very familiar with them. Maintenance is the main cause of discomfort with contact lenses, either through improper use, solution-material incompatibility, or a reaction of the wearer to the components. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  18. Perilous proximity: Does the Janzen-Connell hypothesis explain the distribution of giant barrel sponges on a Florida coral reef?

    Science.gov (United States)

    Deignan, Lindsey K.; Pawlik, Joseph R.

    2015-06-01

    One popular concept used to explain the high biodiversity of some ecosystems is the Janzen-Connell hypothesis, which states that the distribution of conspecifics is controlled by species-specific pathogens or predators that are attracted to adults or to their reproductive output. The distribution of the affected species would then display a distinct pattern, with survivorship increasing at greater distance from the conspecific adult (negative density dependence), leaving a vacant area around the adult where other species can survive. The giant barrel sponge, Xestospongia muta, is an abundant and long-lived sponge on Caribbean coral reefs that is actively grazed by sponge-eating fishes and is susceptible to disease. We tested the Janzen-Connell hypothesis on barrel sponges on Conch Reef, Florida, by examining their distribution as a function of size using spatial point pattern analyses. Clark and Evans tests and a series of Ripley's K function analyses revealed no consistent distribution pattern, with most analyses resulting in a random pattern of sponge distribution. While predation by sponge-eating fishes has recently been discovered to structure sponge communities on reefs across the Caribbean, these top-down effects do not translate to spatial distributions of X. muta that support Janzen-Connell predictions.

  19. Automated Fresnel lens tester system

    Energy Technology Data Exchange (ETDEWEB)

    Phipps, G.S.

    1981-07-01

    An automated data collection system controlled by a desktop computer has been developed for testing Fresnel concentrators (lenses) intended for solar energy applications. The system maps the two-dimensional irradiance pattern (image) formed in a plane parallel to the lens, whereas the lens and detector assembly track the sun. A point detector silicon diode (0.5-mm-dia active area) measures the irradiance at each point of an operator-defined rectilinear grid of data positions. Comparison with a second detector measuring solar insolation levels results in solar concentration ratios over the image plane. Summation of image plane energies allows calculation of lens efficiencies for various solar cell sizes. Various graphical plots of concentration ratio data help to visualize energy distribution patterns.

  20. Compliance among soft contact lens wearers.

    Science.gov (United States)

    Kuzman, Tomislav; Kutija, Marija Barisić; Masnec, Sanja; Jandroković, Sonja; Mrazovac, Danijela; Jurisić, Darija; Skegro, Ivan; Kalauz, Miro; Kordić, Rajko

    2014-12-01

    Contact lens compliance is proven to be crucial for preventing lens wear-related complications because of the interdependence of the steps in lens care regime and their influence on lens system microbial contamination. Awareness of the patients' lens handling compliance as well as correct recognition of non-compliant behaviours is the basis for creating more targeted strategies for patient education. The aim of this study was to investigate compliance among soft contact lens (SCL) wearers in different aspects of lens care handling and wearing habits. In our research 50 asymptomatic lens wearers filled out a questionnaire containing demographic data, lens type, hygiene and wearing habits, lenses and lens care system replacement schedule and self-evaluation of contact lens handling hygiene. We established criteria of compliance according to available manufacturer's recommendations, prior literature and our clinical experience. Only 2 (4%) of patients were fully compliant SCL wearers. The most common non-compliant behaviours were insufficient lens solution soaking time (62%), followed by failure to daily exchange lens case solution and showering while wearing lenses. 44% of patients reported storing lenses in saline solution. Mean lens storage case replacement was 3.6 months, with up to 78% patients replacing lens case at least once in 3 months. Average grade in self evaluating level of compliance was very good (4 +/- 0.78) (from 1-poor level of hygiene to 5-great level of hygiene). Lens wearers who reported excessive daily lens wear and more than 10 years of lens wearing experience were also found to be less compliant with other lens system care procedures. (t = -2.99, df=47, p lens system maintenance steps. Most common non-compliant behaviours were the ones that are crucial for maintaining lens sterility and preventing infection. Despite the low objective compliance rate, self grading was relatively high. Therefore, these results indicate the need for patient

  1. Bad Apples, Bad Barrel: Exploring Institutional Responses to Child Sexual Abuse by Catholic Clergy in Australia

    Directory of Open Access Journals (Sweden)

    Jodi Death

    2015-07-01

    Full Text Available This paper considers constructions of institutional culture and power in the cover-up of child sexual abuse (CSA by clergy in the Roman Catholic Church of Australia. The issue of cover-up has previously been considered in international inquiries as an institutional failing that has caused significant harm to victims of CSA by Catholic Clergy. Evidence given by select representatives of the Catholic Church in two government inquiries into institutional abuse carried out in Australia is considered here. This evidence suggests that, where cover-up has occurred, it has been reliant on the abuse of institutional power and resulted in direct emotional, psychological and spiritual harm to victims of abuse. Despite international recognition of cover-up as institutional abuse, evidence presented by Roman Catholic Representatives to the Victorian Inquiry denied there was an institutionalised cover-up. Responding to this evidence, this paper queries whether the primary foundation of cover-up conforms to the ‘bad apple theory’ in that it relates only to a few individuals, or the ‘bad barrel theory’ of institutional structure and culture.

  2. Computer-aided lens assembly

    Science.gov (United States)

    Tomlinson, Richard; Alcock, Rob; Petzing, Jon; Coupland, Jeremy

    2004-01-01

    We propose a computer-aided method of lens manufacture that allows assembly, adjustment, and test phases to be run concurrently until an acceptable level of optical performance is reached. Misalignment of elements within a compound lens is determined by a comparison of the results of physical ray tracing by use of an array of Gaussian laser beams with numerically obtained geometric ray traces. An estimate of misalignment errors is made, and individual elements are adjusted in an iterative manner until performance criteria are achieved. The method is illustrated for the alignment of an air-spaced doublet.

  3. The Outer Membrane Protein OmpW Forms an Eight-Stranded beta-Barrel with a Hydrophobic Channel

    International Nuclear Information System (INIS)

    Hong, H.; Patel, D.; Tamm, L.; van den Berg, B.

    2006-01-01

    Escherichia coli OmpW belongs to a family of small outer membrane (OM) proteins that are widespread in Gram-negative bacteria. Their functions are unknown, but recent data suggest that they may be involved in the protection of bacteria against various forms of environmental stress. In order to gain insight into the function of these proteins we have determined the crystal structure of Escherichia coli OmpW to 2.7 Angstroms resolution. The structure shows that OmpW forms an eight-stranded beta-barrel with a long and narrow hydrophobic channel that contains a bound LDAO detergent molecule. Single channel conductance experiments show that OmpW functions as an ion channel in planar lipid bilayers. The channel activity can be blocked by the addition of LDAO. Taken together, the data suggest that members of the OmpW family could be involved in the transport of small hydrophobic molecules across the bacterial OM

  4. Acanthamoeba keratitis. Contact lens and noncontact lens characteristics.

    Science.gov (United States)

    Chynn, E W; Lopez, M A; Pavan-Langston, D; Talamo, J H

    1995-09-01

    To identify potential differences in time to diagnosis and final visual outcome between contact lens and noncontact lens users with Acanthamoeba keratitis. Prior studies have shown early diagnosis and therapy to be related to outcome but have not analyzed differences among patients with and without contact lenses. A retrospective analysis of 11 consecutive cases (involving 13 eyes) of Acanthamoeba keratitis diagnosed at one institution over a 3-year period. Mean time to diagnosis was significantly longer in noncontact lens users versus those who wore contact lenses (mean, 5.8 versus 3.3 weeks). Fifty percent of patients who did not wear contact lenses had a poor outcome (visual acuity worse than 20/40 or penetrating keratoplasty) versus 14% of patients who wore contact lenses. Diagnoses were made later in patients without contact lenses, and these patients had a worse visual outcome than those with Acanthamoeba keratitis who wore contact lenses. All patients with unresponsive microbial keratitis, even those without contact lens use, should be evaluated for Acanthamoeba.

  5. A microcapillary lens for X-rays

    CERN Document Server

    Dudchik, Y I

    1999-01-01

    A new design of a compound refractive lens for X-rays is proposed. The lens is made as a set of glue microlenses placed in a glass capillary. The technique of lens fabrication is described. Results of ray tracing calculations for 8 and 15 keV photons are represented.

  6. Triggering and measuring bent cosmic muon tracks with the Muon Spectrometer barrel for the first time

    CERN Multimedia

    Fabio Cerutti

    During the ATLAS barrel toroid stability test, bent cosmic muon tracks were seen for the first time in the ATLAS cavern by means of the ATLAS muon spectrometer. The barrel toroid has been powered at its nominal current (20.5 thousand Amperes) and kept in steady state for more than one day during the weekend of 18-19 November (see a report on this test in the Magnet section). During this test one large sector and part of a small sector of the barrel muon spectrometer were readout and used to detect the cosmic muons tracks bent by the toroidal magnetic field. Thirteen muon stations in the feet sectors (sectors 13 and 14) have been used in this test. The muon stations are formed of Resistive Plate Chambers (RPC) that were providing the muon trigger, and Monitored Drift Tubes that were used to measure with high accuracy the muon curvature hence their momentum. The Level-1 Barrel trigger chain was based on the Barrel Middle Large chambers equipped with final production modules on both the on-detector and the o...

  7. Assembly of a Full-Scale External Tank Barrel Section Using Friction Stir Welding

    Science.gov (United States)

    Jones, Chip; Adams, Glynn

    1999-01-01

    A full-scale pathfinder barrel section of the External Tank for the National Aeronautics and Space Administration (NASA) Space Transport System (Space Shuttle) has been assembled at Marshall Space Flight Center (MSFC) via a collaborative effort between NASA/MSFC and Lockheed Martin Michoud Space Systems. The barrel section is 27.5 feet in diameter and 15 feet in height. The barrel was assembled using Super-Light-Weight (SLWT), orthogrid, Al-Li 2195 panel sections and a single longeron panel. A vertical weld tool at MSFC was modified to accommodate FSW and used to assemble the barrel. These modifications included the addition of a FSW weld head and new controller hardware and software, the addition of a backing anvil and the replacement of the clamping system with individually actuated clamps. Weld process 4evelopment was initially conducted to optimize the process for the welds required for completing the assembly. The variable thickness welds in the longeron section were conducted via both two-sided welds and with the use of a retractable pin tool. The barrel assembly was completed in October 1998. Details of the vertical weld tool modifications and the assembly process are presented.

  8. [Corneal protection in contact lens users].

    Science.gov (United States)

    Egorova, G B; Mitichkina, T S; Shamsudinova, A R

    2014-01-01

    To evaluate the efficacy of corneoprotective agents (Corneregel and Solcoseryl) in contact lens users. A total of 66 long-term contact lens wearers with dry eye symptoms and varying degrees of corneal epitheliopathy were monitored. All patients used artificial tears, which, however, were not effective enough to suppress manifestations of corneal epitheliopathy and to release the associated discomfort. The therapy was supplemented with Corneregel. The following examination methods were applied: biomicroscopy with fluorescent staining, Norn test, Schirmer's test, advanced tearscopy with digital image analysis of the precorneal tear film lipid layer, corneal confocal microscopy. In all cases the assessment was performed prior to starting Corneregel and repeated in 7 days, 14 days and 1 month. Complete corneal re-epithelization and restoration of the most superficial layer of the epithelium were achieved within 7-14 days. In case of severe initial epitheliopathy the effect of Corneregel was not sufficient and epithelium defects remained. These patients additionally received Solcoseryl Eye Gel. After the treatment course the condition of corneal epithelium ameliorated and contact lens wearing comfort increased. A longer precorneal tear film break-up time indicated an increase of tear film stability. The total tear production did not change significantly. The moistening effect of Corneregel and low-viscosity artificial tears together with intensive regeneration of corneal epithelium enables structural recovery of the epithelial membrane and considerable improvement of the anterior corneal stroma. At the first stage of corneoprotective treatment it is appropriate to use preservative-free artificial tears of low and high viscosity. If the effect of tear substitutive therapy is unsatisfactory it is recommended to prescribe Corneregel and Solcoseryl. The regimen is to be adjusted individually.

  9. The Ultrawideband Leaky Lens Antenna

    NARCIS (Netherlands)

    Bruni, S.; Neto, A.; Marliani, F.

    2007-01-01

    A novel directive and nondispersive antenna is presented: the ultrawideband (UWB) leaky lens. It is based on the broad band Cherenkov radiation occurring at a slot printed between different infinite homogeneous dielectrics. The first part of the paper presents the antenna concept and the UWB design.

  10. ECTOPIC LENS EXTRACTION IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Vladimir Pfeifer

    2002-12-01

    Full Text Available Background. Ectopia lentis continues to be a therapeutic challenge for ophthalmologists. It can occur as an isolated condition, after ocular trauma, in association with other ocular disorders, as part of a systemic mesodermal disease or a complication of general metabolic disorders. Minimal subluxation of the lens may cause no visual symptoms, but in more advanced cases serious optical disturbances arise. The most important is amblyopia. Surgical treatment options include iris manipulation, lens discission, aspiration, intracapsular or extracapsular extraction, and pars plana lensectomy. The choice of surgical technique remains controversial, in part because of the historically poor visual results and high rate of perioperative complications, including vitreous loss and retinal detachment.Methods. We describe a surgical technique based on the use of the Cionni endocapsular tension ring, dry irrigation aspiration of lens material, centration of the capsular bag and foldable intraocular lens implantation into the bag. With mentioned surgical technique 8 patients were operated; 4 boys and 4 girls, together 11 eyes.Results. The final BCVA after follow up period improved in 9 eyes and it remained the same as before operation in one eye. Statistical comparison of preoperative and postoperative visual acuities showed significant improvement. On the other hand there was no correlation between preoperative and postoperative visual acuity.Conclusions. This surgical procedure is an alternative approach in solving this challenging cases of ectopia lentis with good postoperative visual rehabilitation.

  11. Spinning pipe gas lens revisited

    CSIR Research Space (South Africa)

    Mafusire, C

    2008-01-01

    Full Text Available , there is little information on optical phase aberrations and no study to date on the propagation parameters of the laser beam, but has rather remained rooted in the domain of ray optics. Researchers revisit the spinning pipe gas lens in this paper with new...

  12. Development of a Laue lens for nuclear astrophysics

    International Nuclear Information System (INIS)

    Barriere, N.

    2008-04-01

    The Laue lenses we study focuses in the domain of 0.1-1 MeV thanks to Bragg diffraction in the volume of a large number of small crystal tiles. The focal length of a typical Laue lens system is of the order of 100 m. This requirement calls for two formation flying satellites maintaining lens and detector at the focal distance. The major breakthrough of Laue lenses is to decouple collecting area from detector area. Concentrating a signal from the large area of a Laue lens onto a small focal spot dramatically increases the signal over background ratio with respect to present technologies. Here is the reason for the long awaited leap in sensitivity. The objective of the present thesis was to improve the concept, finding viable technical solutions towards a future space mission. Two aspects of the lens development have been highlighted in this thesis: the first one is an analytical model of the lens that is used to calculate and improve the performance of a certain configuration, the second aspect concerns the search and the characterization of diffracting media of interest. The lens model developed relies on a fast semi-analytical simulation library, permitting to build several design- and optimisation-tools. For the configuration of a given lens, this code computes the resulting effective area and point spread function in a handful of seconds. The model helps finding lens configurations (mass, pack ratio of the lens rings,...) which are automatically refined to match with effective area and energy coverage constraints. These tools have been used to investigate various design aspects, such as the influence of focal length, size, mosaic spread, structure and materials of crystals, etc... The central evaluation criterion in the model is a figure of merit, based on the compactness of the focal spot and the intensity of the collected signal. The second part of this work addresses the actual search and characterization of crystals potentially interesting for Laue lenses

  13. Lens stem cells may reside outside the lens capsule: an hypothesis

    Directory of Open Access Journals (Sweden)

    Meyer Rita A

    2007-06-01

    Full Text Available Abstract In this paper, we consider the ocular lens in the context of contemporary developments in biological ideas. We attempt to reconcile lens biology with stem cell concepts and a dearth of lens tumors. Historically, the lens has been viewed as a closed system, in which cells at the periphery of the lens epithelium differentiate into fiber cells. Theoretical considerations led us to question whether the intracapsular lens is indeed self-contained. Since stem cells generate tumors and the lens does not naturally develop tumors, we reasoned that lens stem cells may not be present within the capsule. We hypothesize that lens stem cells reside outside the lens capsule, in the nearby ciliary body. Our ideas challenge the existing lens biology paradigm. We begin our discussion with lens background information, in order to describe our lens stem cell hypothesis in the context of published data. Then we present the ciliary body as a possible source for lens stem cells, and conclude by comparing the ocular lens with the corneal epithelium.

  14. Protective Effects of Acetylation on the Pathological Reactions of the Lens Crystallins with Homocysteine Thiolactone.

    Directory of Open Access Journals (Sweden)

    Zeinab Moafian

    Full Text Available Various post-translational lens crystallins modifications result in structural and functional insults, contributing to the development of lens opacity and cataract disorders. Lens crystallins are potential targets of homocysteinylation, particularly under hyperhomocysteinemia which has been indicated in various eye diseases. Since both homocysteinylation and acetylation primarily occur on protein free amino groups, we applied different spectroscopic methods and gel mobility shift analysis to examine the possible preventive role of acetylation against homocysteinylation. Lens crystallins were extensively acetylated in the presence of acetic anhydride and then subjected to homocysteinylation in the presence of homocysteine thiolactone (HCTL. Extensive acetylation of the lens crystallins results in partial structural alteration and enhancement of their stability, as well as improvement of α-crystallin chaperone-like activity. In addition, acetylation partially prevents HCTL-induced structural alteration and aggregation of lens crystallins. Also, acetylation protects against HCTL-induced loss of α-crystallin chaperone activity. Additionally, subsequent acetylation and homocysteinylation cause significant proteolytic degradation of crystallins. Therefore, further experimentation is required in order to judge effectively the preventative role of acetylation on the structural and functional insults induced by homocysteinylation of lens crystallins.

  15. Modern lens antennas for communications engineering

    CERN Document Server

    Thornton, John

    2012-01-01

    The aim of this book is to present the modern design principles and analysis of lens antennas. It gives graduates and RF/Microwave professionals the design insights in order to make full use of lens antennas.  Why do we want to write a book in lens antennas? Because this topic has not been thoroughly publicized, its importance is underestimated. As antennas play a key role in communication systems, recent development in wireless communications would indeed benefit from the characteristics of lens antennas: low profile, and low cost etc.  The major advantages of lens antennas are na

  16. Development of a 3D finite element model of lens microcirculation

    Directory of Open Access Journals (Sweden)

    Vaghefi Ehsan

    2012-09-01

    Full Text Available Abstract Background It has been proposed that in the absence of a blood supply, the ocular lens operates an internal microcirculation system. This system delivers nutrients, removes waste products and maintains ionic homeostasis in the lens. The microcirculation is generated by spatial differences in membrane transport properties; and previously has been modelled by an equivalent electrical circuit and solved analytically. While effective, this approach did not fully account for all the anatomical and functional complexities of the lens. To encapsulate these complexities we have created a 3D finite element computer model of the lens. Methods Initially, we created an anatomically-correct representative mesh of the lens. We then implemented the Stokes and advective Nernst-Plank equations, in order to model the water and ion fluxes respectively. Next we complemented the model with experimentally-measured surface ionic concentrations as boundary conditions and solved it. Results Our model calculated the standing ionic concentrations and electrical potential gradients in the lens. Furthermore, it generated vector maps of intra- and extracellular space ion and water fluxes that are proposed to circulate throughout the lens. These fields have only been measured on the surface of the lens and our calculations are the first 3D representation of their direction and magnitude in the lens. Conclusion Values for steady state standing fields for concentration and electrical potential plus ionic and fluid fluxes calculated by our model exhibited broad agreement with observed experimental values. Our model of lens function represents a platform to integrate new experimental data as they emerge and assist us to understand how the integrated structure and function of the lens contributes to the maintenance of its transparency.

  17. Distributed Wireless Monitoring System for Ullage and Temperature in Wine Barrels

    Science.gov (United States)

    Zhang, Wenqi; Skouroumounis, George K.; Monro, Tanya M.; Taylor, Dennis K.

    2015-01-01

    This paper presents a multipurpose and low cost sensor for the simultaneous monitoring of temperature and ullage of wine in barrels in two of the most important stages of winemaking, that being fermentation and maturation. The distributed sensor subsystem is imbedded within the bung of the barrel and runs on battery for a period of at least 12 months and costs around $27 AUD for all parts. In addition, software was designed which allows for the remote transmission and easy visual interpretation of the data for the winemaker. Early warning signals can be sent when the temperature or ullage deviates from a winemakers expectations so remedial action can be taken, such as when topping is required or the movement of the barrels to a cooler cellar location. Such knowledge of a wine’s properties or storage conditions allows for a more precise control of the final wine quality. PMID:26266410

  18. Performance of the ATLAS Level-1 muon barrel trigger during the Run 2 data taking

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00404546; The ATLAS collaboration

    2018-01-01

    The Level-1 Muon Barrel Trigger is one of the main elements of the event selection of the ATLAS experiment at the Large Hadron Collider. It exploits the Resistive Plate Chambers (RPC) detectors to generate the trigger signal. The RPCs are placed in the barrel region of the ATLAS experiment: they are arranged in three concentric double layers and operate in a strong magnetic toroidal field. RPC detectors cover the pseudo-rapidity range |η| < 1.05 for a total surface of more than 4000 m 2 and about 3600 gas volumes. The Level-1 Muon Trigger in the barrel region allows to select muon candidates according to their transverse momentum and associates them with the correct bunch-crossing. The trigger system is able to take a decision within a latency of about 2 μs. The measurement of the RPC detector efficiencies and the trigger performance during the ATLAS Run-II data taking are here presented.

  19. Distributed Wireless Monitoring System for Ullage and Temperature in Wine Barrels

    Directory of Open Access Journals (Sweden)

    Wenqi Zhang

    2015-08-01

    Full Text Available This paper presents a multipurpose and low cost sensor for the simultaneous monitoring of temperature and ullage of wine in barrels in two of the most important stages of winemaking, that being fermentation and maturation. The distributed sensor subsystem is imbedded within the bung of the barrel and runs on battery for a period of at least 12 months and costs around $27 AUD for all parts. In addition, software was designed which allows for the remote transmission and easy visual interpretation of the data for the winemaker. Early warning signals can be sent when the temperature or ullage deviates from a winemakers expectations so remedial action can be taken, such as when topping is required or the movement of the barrels to a cooler cellar location. Such knowledge of a wine’s properties or storage conditions allows for a more precise control of the final wine quality.

  20. Science Highlights from the Balloon Array for Radiation belt Electron Losses (BARREL)

    Science.gov (United States)

    Millan, R. M.

    2016-12-01

    In the inner magnetosphere where the plasmasphere, ring current and radiation belts overlap, energy and momentum are exchanged between different plasma populations by plasma waves. Resonant interaction with these waves can lead to rapid loss of radiation belt and ring current electrons to the atmosphere. Over the past four years, more than 50 BARREL balloons have been launched, making observations of energetic ( 20 keV - 10 MeV) electron precipitation in both hemispheres. The combination of BARREL multi-point balloon measurements with measurements from equatorial spacecraft (e.g. Van Allen Probes, LANL, THEMIS, GOES), LEO spacecraft (POES, CSSWE, FIREBIRD, AC-6), and ground-based instruments is providing a unique opportunity to quantify the spatial scale of energetic precipitation and to study the wave-particle interactions that cause precipitation. This presentation will focus on science results from recent BARREL campaigns, shedding light on outstanding questions about energetic electron precipitation.

  1. Design and fabrication of an advanced, lightweight, high stiffness, railgun barrel concept

    International Nuclear Information System (INIS)

    Vrable, D.L.; Rosenwasser, S.N.; Korican, J.A.

    1991-01-01

    An advanced lightweight and high stiffness railgun barrel design and incorporates several new design features and advanced materials is being developed by SPARTA, Inc. The program is sponsored by the U.S. Army Armament Research, Development, and Engineering Center ARDEC and by the Defense Advanced Research Projects Agency (DARPA). The railgun is 7 m long and has a 90 mm round bore. It is designed to accommodate both solid and plasma armatures. Muzzle energies are expected in the range of 9 to 15 MJ. Analysis and final design has been completed and the barrel and other railgun subassemblies are in the fabrication stage at SPARTA, Inc. in San Diego, California. Initial testing will be conducted at Maxwell Laboratories Green Farm facility in September 1990 and will subsequently be shipped to the ARDEC Railgun Laboratory in October 1990 for full power operation and testing. This paper discusses the design features and fabrication approaches for this high performance, lightweight railgun barrel system

  2. Early stages in the biogenesis of eukaryotic β-barrel proteins.

    Science.gov (United States)

    Jores, Tobias; Rapaport, Doron

    2017-09-01

    The endosymbiotic organelles mitochondria and chloroplasts harbour, similarly to their prokaryotic progenitors, β-barrel proteins in their outer membrane. These proteins are encoded on nuclear DNA, translated on cytosolic ribosomes and imported into their target organelles by a dedicated machinery. Recent studies have provided insights into the import into the organelles and the membrane insertion of these proteins. Although the cytosolic stages of their biogenesis are less well defined, it is speculated that upon their synthesis, chaperones prevent β-barrel proteins from aggregation and keep them in an import-competent conformation. In this Review, we summarize the current knowledge about the biogenesis of β-barrel proteins, focusing on the early stages from the translation on cytosolic ribosomes to the recognition on the surface of the organelle. © 2017 Federation of European Biochemical Societies.

  3. Contact lens surface by electron beam

    International Nuclear Information System (INIS)

    Shin, Jung Hyuck; Lee, Suk Ju; Hwang, Kwang Ha; Jeon Jin

    2011-01-01

    Contact lens materials needs good biocompatibility, high refractive index, high optical transparency, high water content etc. Surface treat method by using plasma and radiation can modify the physical and/or chemical properties of the contact lens surface. Radiation technology such as electron beam irradiation can apply to polymerization reaction and enhance the functionality of the polymer.The purpose of this study is to modify of contact lens surface by using Eb irradiation technology. Electron beam was irradiated to the contact lens surface which was synthesized thermal polymerization method and commercial contact lens to modify physical and chemical properties. Ft-IR, XP, UV-vis spectrophotometer, water content, oxygen trans-metastability were used to characterize the surface state, physicochemical, and optical property of the contact lens treated with Eb. The water content and oxygen transmissibility of the contact lens treated with Eb were increased due to increase in the hydrophilic group such as O-C=O and OH group on the contact lens surface which could be produced by possible reaction between carbon and oxygen during the Eb irradiation. All of the lenses showed the high optical transmittance above 90%. In this case of B/Es, TES, Ti contact lens, the optical transmittance decreased about 5% with increasing Eb dose in the wavelength of UV-B region. The contact lens modified by Eb irradiation could improve the physical properties of the contact lens such as water content and oxygen transmissibility

  4. Lens decenter and tilt measurement by interferogram

    Science.gov (United States)

    Hung, Min-Wei; Wu, Wen-Hong; Huang, Kuo-Cheng

    2009-11-01

    For the recent years, the vigorous development of the electro-optic industry, particularly the digital camera and the cellular phone camera, has placed a larger and larger demand for the optical devices. Among the optical lens, the aspherical optical lens plays the key component because the aspherical lens may provide better imaging quality then the spherical lens does. For the manufacturing reason, the aspherical lens is prone to a decenter or tilt issue with respect to the optical axes of its two surfaces. To measure decenter and tile error specifically would help to obviate the deficient lens, but most of the present measuring method can't provide this function. This paper proposed a new method to specifically measure the decenter and tile of lens by observing the interferogram of each surface. And the corresponding measuring instrument, which contains interferometer and motion stages, was introduced as well.

  5. Curiosity's Mars Hand Lens Imager (MAHLI) Investigation

    Science.gov (United States)

    Edgett, Kenneth S.; Yingst, R. Aileen; Ravine, Michael A.; Caplinger, Michael A.; Maki, Justin N.; Ghaemi, F. Tony; Schaffner, Jacob A.; Bell, James F.; Edwards, Laurence J.; Herkenhoff, Kenneth E.; Heydari, Ezat; Kah, Linda C.; Lemmon, Mark T.; Minitti, Michelle E.; Olson, Timothy S.; Parker, Timothy J.; Rowland, Scott K.; Schieber, Juergen; Sullivan, Robert J.; Sumner, Dawn Y.; Thomas, Peter C.; Jensen, Elsa H.; Simmonds, John J.; Sengstacken, Aaron J.; Wilson, Reg G.; Goetz, Walter

    2012-01-01

    The Mars Science Laboratory (MSL) Mars Hand Lens Imager (MAHLI) investigation will use a 2-megapixel color camera with a focusable macro lens aboard the rover, Curiosity, to investigate the stratigraphy and grain-scale texture, structure, mineralogy, and morphology of geologic materials in northwestern Gale crater. Of particular interest is the stratigraphic record of a ?5 km thick layered rock sequence exposed on the slopes of Aeolis Mons (also known as Mount Sharp). The instrument consists of three parts, a camera head mounted on the turret at the end of a robotic arm, an electronics and data storage assembly located inside the rover body, and a calibration target mounted on the robotic arm shoulder azimuth actuator housing. MAHLI can acquire in-focus images at working distances from ?2.1 cm to infinity. At the minimum working distance, image pixel scale is ?14 μm per pixel and very coarse silt grains can be resolved. At the working distance of the Mars Exploration Rover Microscopic Imager cameras aboard Spirit and Opportunity, MAHLI?s resolution is comparable at ?30 μm per pixel. Onboard capabilities include autofocus, auto-exposure, sub-framing, video imaging, Bayer pattern color interpolation, lossy and lossless compression, focus merging of up to 8 focus stack images, white light and longwave ultraviolet (365 nm) illumination of nearby subjects, and 8 gigabytes of non-volatile memory data storage.

  6. GRAVITATIONAL LENS MODELING WITH GENETIC ALGORITHMS AND PARTICLE SWARM OPTIMIZERS

    International Nuclear Information System (INIS)

    Rogers, Adam; Fiege, Jason D.

    2011-01-01

    Strong gravitational lensing of an extended object is described by a mapping from source to image coordinates that is nonlinear and cannot generally be inverted analytically. Determining the structure of the source intensity distribution also requires a description of the blurring effect due to a point-spread function. This initial study uses an iterative gravitational lens modeling scheme based on the semilinear method to determine the linear parameters (source intensity profile) of a strongly lensed system. Our 'matrix-free' approach avoids construction of the lens and blurring operators while retaining the least-squares formulation of the problem. The parameters of an analytical lens model are found through nonlinear optimization by an advanced genetic algorithm (GA) and particle swarm optimizer (PSO). These global optimization routines are designed to explore the parameter space thoroughly, mapping model degeneracies in detail. We develop a novel method that determines the L-curve for each solution automatically, which represents the trade-off between the image χ 2 and regularization effects, and allows an estimate of the optimally regularized solution for each lens parameter set. In the final step of the optimization procedure, the lens model with the lowest χ 2 is used while the global optimizer solves for the source intensity distribution directly. This allows us to accurately determine the number of degrees of freedom in the problem to facilitate comparison between lens models and enforce positivity on the source profile. In practice, we find that the GA conducts a more thorough search of the parameter space than the PSO.

  7. Status of the effectiveness of contact lens disinfectants in Malaysia against keratitis-causing pathogens.

    Science.gov (United States)

    Abjani, Farhat; Khan, Naveed Ahmed; Jung, Suk Yul; Siddiqui, Ruqaiyyah

    2017-12-01

    The aim of this study was (i) to assess the antimicrobial effects of contact lens disinfecting solutions marketed in Malaysia against common bacterial eye pathogens and as well as eye parasite, Acanthamoeba castellanii, and (ii) to determine whether targeting cyst wall would improve the efficacy of contact lens disinfectants. Using ISO 14729 Stand-Alone Test for disinfecting solutions, bactericidal and amoebicidal assays of six different contact lens solutions including Oxysept ® , AO SEPT PLUS, OPTI-FREE ® pure moist ® , Renu ® fresh™, FreshKon ® CLEAR and COMPLETE RevitaLens™ were performed using Manufacturers Minimum recommended disinfection time (MRDT). The efficacy of contact lens solutions was determined against keratitis-causing microbes, namely: Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, and Acanthamoeba castellanii. In addition, using chlorhexidine as an antiamoebic compound and cellulase enzyme to disrupt cyst wall structure, we determined whether combination of both agents can enhance efficacy of marketed contact lens disinfectants against A. castellanii trophozoites and cysts, in vitro. The results revealed that all contact lens disinfectants tested showed potent bactericidal effects exhibiting 100% kill against all bacterial species tested. In contrast, none of the contact lens disinfectants had potent effects against Acanthamoeba cysts viability. When tested against trophozoites, two disinfectants, Oxysept Multipurpose and AO-sept Multipurpose showed partial amoebicidal effects. Using chlorhexidine as an antiamoebic compound and cellulase enzyme to disrupt cyst wall structure, the findings revealed that combination of both agents in contact lens disinfectants abolished viability of A. castellanii cysts and trophozoites. Given the inefficacy of contact lens disinfectants tested in this study, these findings present a significant concern to public health. These

  8. Optimization of a multilayer Laue lens system for a hard x-ray nanoprobe

    International Nuclear Information System (INIS)

    Jiang, Hui; Wang, Hua; Mao, Chengwen; Li, Aiguo; He, Yan; Dong, Zhaohui; Zheng, Yi

    2014-01-01

    Detailed designs of a multilayer Laue lens system for a hard x-ray nanoprobe, including flat and wedged types, are presented, to realize nanoscale point focus and high diffraction efficiency simultaneously. The difficulty of movement and alignment for lens, aperture and sample are considered in the optimization process. Considering the practical requirements of future experiments, the features of the beamline and the structural imperfections, the working energy range, the beam vibration and structural errors are estimated and discussed. (paper)

  9. The Sloan Lens ACS Survey. I. A Large Spectroscopically Selected Sample of Massive Early-Type Lens Galaxies

    Science.gov (United States)

    Bolton, Adam S.; Burles, Scott; Koopmans, Leon V. E.; Treu, Tommaso; Moustakas, Leonidas A.

    2006-01-01

    The Sloan Lens ACS (SLACS) Survey is an efficient Hubble Space Telescope (HST) Snapshot imaging survey for new galaxy-scale strong gravitational lenses. The targeted lens candidates are selected spectroscopically from the Sloan Digital Sky Survey (SDSS) database of galaxy spectra for having multiple nebular emission lines at a redshift significantly higher than that of the SDSS target galaxy. The SLACS survey is optimized to detect bright early-type lens galaxies with faint lensed sources in order to increase the sample of known gravitational lenses suitable for detailed lensing, photometric, and dynamical modeling. In this paper, the first in a series on the current results of our HST Cycle 13 imaging survey, we present a catalog of 19 newly discovered gravitational lenses, along with nine other observed candidate systems that are either possible lenses, nonlenses, or nondetections. The survey efficiency is thus >=68%. We also present Gemini 8 m and Magellan 6.5 m integral-field spectroscopic data for nine of the SLACS targets, which further support the lensing interpretation. A new method for the effective subtraction of foreground galaxy images to reveal faint background features is presented. We show that the SLACS lens galaxies have colors and ellipticities typical of the spectroscopic parent sample from which they are drawn (SDSS luminous red galaxies and quiescent MAIN sample galaxies), but are somewhat brighter and more centrally concentrated. Several explanations for the latter bias are suggested. The SLACS survey provides the first statistically significant and homogeneously selected sample of bright early-type lens galaxies, furnishing a powerful probe of the structure of early-type galaxies within the half-light radius. The high confirmation rate of lenses in the SLACS survey suggests consideration of spectroscopic lens discovery as an explicit science goal of future spectroscopic galaxy surveys.

  10. Horizontal Synchronization of Neuronal Activity in the Barrel Cortex of the Neonatal Rat by Spindle-Burst Oscillations

    Science.gov (United States)

    Suchkov, Dmitrii; Sharipzyanova, Lyaila; Minlebaev, Marat

    2018-01-01

    During development, activity in the somatosensory cortex is characterized by intermittent oscillatory bursts at gamma (early gamma-oscillations, EGOs) and alpha–beta (spindle-bursts, SBs) frequencies. Here, we explored the topography of EGOs and SBs in the neighbor barrels of the whisker-related barrel cortex of neonatal rats (P4-7) during responses evoked by simultaneous activation of multiple whiskers as it occurs during natural conditions. We found that brief simultaneous deflection of all whiskers evoked complex neuronal responses comprised of EGOs and SBs. In contrast to EGOs, that specifically synchronized neuronal activity in each individual barrel, SBs efficiently synchronized activity between neighboring barrels. After plucking a single whisker, synchronous stimulation of spared whiskers evoked EGO-lacking responses in the whisker-deprived barrel, even though the remaining neuronal activity was synchronized by SBs in neighboring barrels. Thus, EGOs specifically support topographic synchronization of neuronal activity within barrels, whereas SBs support horizontal synchronization between neighboring barrels during stimulation of multiple whiskers. We suggest that these two co-existing activity patterns coordinate activity-dependent formation of topographic maps and support the emergence of integrative functions in the primary somatosensory cortex during the critical period of somatosensory maps development. PMID:29403359

  11. Horizontal Synchronization of Neuronal Activity in the Barrel Cortex of the Neonatal Rat by Spindle-Burst Oscillations

    Directory of Open Access Journals (Sweden)

    Dmitrii Suchkov

    2018-01-01

    Full Text Available During development, activity in the somatosensory cortex is characterized by intermittent oscillatory bursts at gamma (early gamma-oscillations, EGOs and alpha–beta (spindle-bursts, SBs frequencies. Here, we explored the topography of EGOs and SBs in the neighbor barrels of the whisker-related barrel cortex of neonatal rats (P4-7 during responses evoked by simultaneous activation of multiple whiskers as it occurs during natural conditions. We found that brief simultaneous deflection of all whiskers evoked complex neuronal responses comprised of EGOs and SBs. In contrast to EGOs, that specifically synchronized neuronal activity in each individual barrel, SBs efficiently synchronized activity between neighboring barrels. After plucking a single whisker, synchronous stimulation of spared whiskers evoked EGO-lacking responses in the whisker-deprived barrel, even though the remaining neuronal activity was synchronized by SBs in neighboring barrels. Thus, EGOs specifically support topographic synchronization of neuronal activity within barrels, whereas SBs support horizontal synchronization between neighboring barrels during stimulation of multiple whiskers. We suggest that these two co-existing activity patterns coordinate activity-dependent formation of topographic maps and support the emergence of integrative functions in the primary somatosensory cortex during the critical period of somatosensory maps development.

  12. 27 CFR 25.160 - Tax adjustment for brewers who produce more than 2,000,000 barrels of beer.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Tax adjustment for brewers who produce more than 2,000,000 barrels of beer. 25.160 Section 25.160 Alcohol, Tobacco Products and... the higher and lower rates of tax applicable to beer by the number of barrels removed by the brewer...

  13. Looking beyond the perfect lens

    International Nuclear Information System (INIS)

    Wee, W H; Pendry, J B

    2010-01-01

    The holy grail of imaging is the ability to see through anything. From the conservation of energy, we can easily see that to see through a lossy material would require lenses with gain. The aim of this paper therefore is to propose a simple scheme by which we can construct a general perfect lens, with gain-one that can restore both the phases and amplitudes of near and far fields.

  14. Eukaryote-wide sequence analysis of mitochondrial β-barrel outer membrane proteins

    Directory of Open Access Journals (Sweden)

    Fujita Naoya

    2011-01-01

    Full Text Available Abstract Background The outer membranes of mitochondria are thought to be homologous to the outer membranes of Gram negative bacteria, which contain 100's of distinct families of β-barrel membrane proteins (BOMPs often forming channels for transport of nutrients or drugs. However, only four families of mitochondrial BOMPs (MBOMPs have been confirmed to date. Although estimates as high as 100 have been made in the past, the number of yet undiscovered MBOMPs is an open question. Fortunately, the recent discovery of a membrane integration signal (the β-signal for MBOMPs gave us an opportunity to look for undiscovered MBOMPs. Results We present the results of a comprehensive survey of eukaryotic protein sequences intended to identify new MBOMPs. Our search employs recent results on β-signals as well as structural information and a novel BOMP predictor trained on both bacterial and mitochondrial BOMPs. Our principal finding is circumstantial evidence suggesting that few MBOMPs remain to be discovered, if one assumes that, like known MBOMPs, novel MBOMPs will be monomeric and β-signal dependent. In addition to this, our analysis of MBOMP homologs reveals some exceptions to the current model of the β-signal, but confirms its consistent presence in the C-terminal region of MBOMP proteins. We also report a β-signal independent search for MBOMPs against the yeast and Arabidopsis proteomes. We find no good candidates MBOMPs in yeast but the Arabidopsis results are less conclusive. Conclusions Our results suggest there are no remaining MBOMPs left to discover in yeast; and if one assumes all MBOMPs are β-signal dependent, few MBOMP families remain undiscovered in any sequenced organism.

  15. CONTACT LENS RELATED CORNEAL ULCER

    Directory of Open Access Journals (Sweden)

    AGARWAL P

    2010-01-01

    Full Text Available A corneal ulcer caused by infection is one of the major causes of blindness worldwide. One of the recent health concerns is the increasing incidence of corneal ulcers associated with contact lens user especially if the users fail to follow specific instruction in using their contact lenses. Risk factors associated with increased risk of contact lens related corneal ulcers are:overnight wear, long duration of continuous wear, lower socio-economic classes, smoking, dry eye and poor hygiene. The presenting symptoms of contact lens related corneal ulcers include eye discomfort, foreign body sensation and lacrimation. More serious symptoms are redness (especially circum-corneal injection, severe pain, photophobia, eye discharge and blurring of vision. The diagnosis is established by a thorough slit lamp microscopic examination with fluorescein staining and corneal scraping for Gram stain and culture of the infective organism. Delay in diagnosing and treatment can cause permanent blindness, therefore an early referral to ophthalmologist and commencing of antimicrobial therapy can prevent visual loss.

  16. Construction and test of the final CMS barrel drift tube muon chamber prototype

    CERN Document Server

    Aguilar-Benítez, M; Arneodo, M; Banicz, K; Benettoni, M; Benvenuti, Alberto C; Bethke, Siegfried; Cerrada, M; Cirio, R; Colino, N; Conti, E; Dallavalle, G M; Daniel, M; Dattola, D; Daudo, F; De Giorgi, M; Dosselli, U; Fanfani, A; Fanin, C; Fouz-Iglesias, M C; Gasparini, F; Gasparini, U; Glacomelli, P; Giordano, V; Gonella, F; Grandi, C; Guaita, P; Guerzoni, M; Lacaprara, S; Lippi, I; Marcellini, S; Marin, J; Martinelli, R; Maselli, S; Meneguzzo, Anna Teresa; Migliore, E; Mocholí-Mocholí, J; Monaco, V; Montanari, A; Montnari, C; Odorici, F; Oller, J C; Paoletti, S; Passaseo, M; Pegoraro, M; Peroni, C; Puerta, J; Reithler, H; Romero, A; Romero, L; Ronchese, P; Rossi, A M; Rovelli, T; Sacchi, R; Salicio, J M; Staiano, A; Steinbeck, T M; Torassa, E; Travaglini, R; Ventura, L; Ventura, Sandro; Vitelli, A; Voetee, F; Wegner, M; Willmott, C; Zotto, P L; Zumerle, G

    2002-01-01

    A prototype of the CMS Barrel Muon Detector incorporating all the features of the final chambers was built using the mass production assembly procedures and tools. The performance of this prototype was studied in a muon test beam at CERN and the results obtained are presented in this paper. (12 refs).

  17. Electrostatic design of the barrel CRID [Cherenkov Ring Imaging Detector] and associated measurements

    International Nuclear Information System (INIS)

    Abe, K.; Hasegawa, K.; Suekane, F.; Yuta, H.; Bean, A.; Caldwell, D.; Duboscq, J.; Hale, D.; Huber, J.; Lu, A.; Mathys, L.; McHugh, S.; Morrison, R.; Witherell, M.; Yellin, S.; Coyle, P.; Coyne, D.; Gagnon, P.; Williams, D.A.; Jacques, P.; Plano, R.; Stamer, P.; Hasegawa, K.; Johnson, R.A.; Martinez, J.; Nussbaum, M.; Santha, K.S.; Shoup, A.; Stockdale, I.; Suekane, F.; Whitaker, J.S.; Wilson, R.J.

    1990-04-01

    We report on the electrostatic design and related measurements of the barrel Cherenkov Ring Imaging Detector for the Stanford Large Detector experiment at the Stanford Linear Accelerator Center Linear Collider. We include test results of photon feedback in TMAE-laden gas, distortion measurements in the drift boxes and corona measurements. 13 refs., 21 figs

  18. Electrostatic design of the barrel CRID (Cherenkov Ring Imaging Detector) and associated measurements

    Energy Technology Data Exchange (ETDEWEB)

    Abe, K.; Hasegawa, K.; Suekane, F.; Yuta, H. (Tohoku Univ., Sendai (Japan). Dept. of Physics); Antilogus, P.; Aston, D.; Bienz, T.; Bird, F.; Dunwoodie, W.; Hallewell, G.; Kawahara, H.; Kwon, Y.; Leith, D.W.G.S.; Muller, D.; Nagamine, T.; Pavel, T.; Ratcliff, B.; Rensing, P.; Schultz, D.; Shapiro, S.; Simopoulos, C.; Solodov, E.; Toge, N.; Va' Vra, J. Williams, H. (Stanford Linear Accelerator Center, Menlo Park, CA (US

    1990-04-01

    We report on the electrostatic design and related measurements of the barrel Cherenkov Ring Imaging Detector for the Stanford Large Detector experiment at the Stanford Linear Accelerator Center Linear Collider. We include test results of photon feedback in TMAE-laden gas, distortion measurements in the drift boxes and corona measurements. 13 refs., 21 figs.

  19. Cosmic tests and performance of the ATLAS SemiConductor Tracker Barrels

    International Nuclear Information System (INIS)

    Demirkoez, Bilge M.

    2007-01-01

    ATLAS is a multi-purpose particle detector for the LHC and will detect proton collisions with center of mass energy of 14TeV. Part of the central inner detector, the SemiConductor Tracker (SCT) barrel, is now fully integrated with the Transition Radiation Tracker (TRT) barrel. The SCT module performance has been measured after module production, after macro-assembly of modules onto barrels, after arrival at CERN and again partially after integration with the TRT. The module noise average per channel has been stable and is 4.5x10 -5 , well below the design specification of 5x10 -4 . There is no evidence for common mode noise problems and 99.8% of the 3.2 million channels of the SCT barrels are functional. The cosmics running of the SCT and TRT was the first large scale test of the physics mode of the SCT online software framework. A large sector, 468 SCT modules, has been timed in and read out during the cosmic tests. Tracks have been reconstructed through the SCT and the TRT sectors. Present residuals from tracks (without alignment) are better than the specified building tolerances of the SCT

  20. Late emergence of the vibrissa direction selectivity map in the rat barrel cortex.

    Science.gov (United States)

    Kremer, Yves; Léger, Jean-François; Goodman, Dan; Brette, Romain; Bourdieu, Laurent

    2011-07-20

    In the neocortex, neuronal selectivities for multiple sensorimotor modalities are often distributed in topographical maps thought to emerge during a restricted period in early postnatal development. Rodent barrel cortex contains a somatotopic map for vibrissa identity, but the existence of maps representing other tactile features has not been clearly demonstrated. We addressed the issue of the existence in the rat cortex of an intrabarrel map for vibrissa movement direction using in vivo two-photon imaging. We discovered that the emergence of a direction map in rat barrel cortex occurs long after all known critical periods in the somatosensory system. This map is remarkably specific, taking a pinwheel-like form centered near the barrel center and aligned to the barrel cortex somatotopy. We suggest that this map may arise from intracortical mechanisms and demonstrate by simulation that the combination of spike-timing-dependent plasticity at synapses between layer 4 and layer 2/3 and realistic pad stimulation is sufficient to produce such a map. Its late emergence long after other classical maps suggests that experience-dependent map formation and refinement continue throughout adult life.

  1. Construction and Performance of the ATLAS SCT Barrels and Cosmic Tests

    CERN Document Server

    Demirkoz, Bilge Melahat

    2007-01-01

    ATLAS is a multi-purpose detector for the LHC and will detect proton-proton collisions with center of mass energy of $14$TeV. Part of the central inner detector, the Semi-Conductor Tracker (SCT) barrels, were assembled and tested at Oxford University and later integrated at CERN with the TRT (Transition Radiation Tracker) barrel. The barrel SCT is composed of 4 layers of silicon strip modules with two sensor layers with $80 \\mu$m channel width. The design of the modules and the barrels has been optimized for low radiation length while maintaining mechanical stability, bringing services to the detector, and ensuring a cold and dry environment. The high granularity, high detector efficiency and low noise occupancy ($ < 5 \\times 10^{-4}$) of the SCT will enable ATLAS to have an efficient pattern recognition capability. Due to the binary nature of the SCT read-out, a stable read-out system and the calibration system is of critical importance. SctRodDaq is the online software framework for the calibration and a...

  2. Tob38, a novel essential component in the biogenesis of β-barrel proteins of mitochondria

    Science.gov (United States)

    Waizenegger, Thomas; Habib, Shukry J; Lech, Maciej; Mokranjac, Dejana; Paschen, Stefan A; Hell, Kai; Neupert, Walter; Rapaport, Doron

    2004-01-01

    Insertion of β-barrel proteins into the outer membrane of mitochondria is mediated by the TOB complex. Known constituents of this complex are Tob55 and Mas37. We identified a novel component, Tob38. It is essential for viability of yeast and the function of the TOB complex. Tob38 is exposed on the surface of the mitochondrial outer membrane. It interacts with Mas37 and Tob55 and is associated with Tob55 even in the absence of Mas37. The Tob38–Tob55 core complex binds precursors of β-barrel proteins and facilitates their insertion into the outer membrane. Depletion of Tob38 results in strongly reduced levels of Tob55 and Mas37 and the residual proteins no longer form a complex. Tob38-depleted mitochondria are deficient in the import of β-barrel precursor proteins, but not of other outer membrane proteins or proteins of other mitochondrial subcompartments. We conclude that Tob38 has a crucial function in the biogenesis of β-barrel proteins of mitochondria. PMID:15205677

  3. Studies of hadron-electron separators for the ZEUS barrel calorimeter

    Energy Technology Data Exchange (ETDEWEB)

    Ambats, I.; Bortz, D.; Connolly, A. [and others

    1995-05-25

    Two possible upgrades, a shower maximum detector and a presampler, designed to improve the low energy electron/hadron separation capabilities of the ZEUS barrel calorimeter are described and test-beam results are reported. The presampler can also be used to correct for energy loss of particles traversing the dead material in front of the calorimeter.

  4. Construction and test of the final CMS Barrel Drift Tube Muon Chamber prototype

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Benitez, M.; Alberdi, J.; Arneodo, M.; Banicz, K.; Benettoni, M.; Benvenuti, A.; Bethke, S.; Cerrada, M. E-mail: cerrada@ciemat.es; Cirio, R.; Colino, N.; Conti, E.; Dallavalle, M.; Daniel, M.; Dattola, D.; Daudo, F.; De Giorgi, M.; Dosselli, U.; Fanfani, A.; Fanin, C.; Fouz, M.C.; Gasparini, F.; Gasparini, U.; Giacomelli, P.; Giordano, V.; Gonella, F.; Grandi, C.; Guaita, P.; Guerzoni, M.; Lacaprara, S.; Lippi, I.; Marcellini, S.; Marin, J.; Martinelli, R.; Maselli, S.; Meneguzzo, A.; Migliore, E.; Mocholi, J.; Monaco, V.; Montanari, A.; Montanari, C.; Odorici, F.; Oller, J.C.; Paoletti, S.; Passaseo, M.; Pegoraro, M.; Peroni, C.; Puerta, J.; Reithler, H.; Romero, A.; Romero, L.; Ronchese, P.; Rossi, A.M.; Rovelli, T.; Sacchi, R.; Salicio, J.M.; Staiano, A.; Steinbeck, T.; Torassa, E.; Travaglini, R.; Ventura, L.; Ventura, S.; Vitelli, A.; Voetee, F.; Wegner, M.; Willmott, C.; Zotto, P.; Zumerle, G

    2002-03-21

    A prototype of the CMS Barrel Muon Detector incorporating all the features of the final chambers was built using the mass production assembly procedures and tools. The performance of this prototype was studied in a muon test beam at CERN and the results obtained are presented in this paper.

  5. Npas4 Expression in Two Experimental Models of the Barrel Cortex Plasticity

    Directory of Open Access Journals (Sweden)

    Aleksandra Kaliszewska

    2015-01-01

    Full Text Available Npas4 has recently been identified as an important factor in brain plasticity, particularly in mechanisms of inhibitory control. Little is known about Npas4 expression in terms of cortical plasticity. In the present study expressions of Npas4 and the archetypal immediate early gene (IEG c-Fos were investigated in the barrel cortex of mice after sensory deprivation (sparing one row of whiskers for 7 days or sensory conditioning (pairing stimulation of one row of whiskers with aversive stimulus. Laser microdissection of individual barrel rows allowed for analysis of IEGs expression precisely in deprived and nondeprived barrels (in deprivation study or stimulated and nonstimulated barrels (in conditioning study. Cortex activation by sensory conditioning was found to upregulate the expression of both Npas4 and c-Fos. Reorganization of cortical circuits triggered by removal of selected rows of whiskers strongly affected c-Fos but not Npas4 expression. We hypothesize that increased inhibitory synaptogenesis observed previously after conditioning may be mediated by Npas4 expression.

  6. Demonstrating the effect of forensic firearm countermeasures: Bullet characteristics generated due to barrel modifications.

    Science.gov (United States)

    O'Keeffe, C; Champion, S; Allsop, D

    2015-12-01

    Forensic awareness and the declining availability of firearms have resulted in an increase in the use of modified and re-activated firearms in crime. Although some modifications are undertaken to simply acquire a functioning firearm, others are perpetrated as a direct forensic countermeasure to prevent the association between a firearm and a crime. This article describes the effects of these modifications on bullet striation patterns imparted from the barrel to a fired bullet. The key results indicated that the investigated modifications display assessable characteristics. The use of an oversized barrel imparted striations consistent with firing with the absence of typical rifling. Subsequent or consecutively fired bullets possessed striation variations, with the first showing the least evidence of striations. The application of a choke resulted in more obvious bullet elongation compared to a smoothbore barrel. The restriction caused merging of lands and groves of the imparted rifling and obscured their usual definition. Effects of breech adaption were also characterised by observing the buckling and enlargement of the cartridge case. This deformity of the cartridge case was most evident when the barrel pressure increased due to the presence of the choke. From this study it was evident that unique characteristic impressions associated with different modifications most commonly found in criminal investigations can be utilised by a forensic expert and impart significant intelligence to an investigation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. Dependence of Oak-Related Volatile Compounds on the Physicochemical Characteristics of Barrel-Aged Wines

    Directory of Open Access Journals (Sweden)

    Pedro Rodríguez-Rodríguez

    2012-01-01

    Full Text Available This paper focuses on the effect of some of the physicochemical characteristics of wines such as volatile acidity, titratable acidity, pH, free SO2 and alcohol content on the accumulation of oak-related volatile compounds in barrel-aged wines, in order to give more light on the contradictory results found by other authors in this respect. For this, three different single variety wines were aged for twelve months in barrels with the same characteristics (same cooperage, wood origin, toasting level and volume, repeating the experiment in two consecutive years. Our results show that the percentage of wine alcohol and its titratable acidity positively correlated with the final concentration of vanillin and guaiacyl compounds in the oak-matured wines and negatively with the cis- and trans-β-methyl-γ-octalactone concentration. Therefore, when studying the effect of oak barrel variables (oak origin and seasoning, size of the barrel, number of uses, etc. on the concentration of oak-related volatile compounds in wine, the effect of the physicochemical variables of the wine, especially titratable acidity and alcohol content, should also be taken into account since the final wine aroma composition will also depend on these characteristics.

  8. Phenolic Composition and Related Properties of Aged Wine Spirits: Influence of Barrel Characteristics. A Review

    Directory of Open Access Journals (Sweden)

    Sara Canas

    2017-11-01

    Full Text Available The freshly distilled wine spirit has a high concentration of ethanol and many volatile compounds, but is devoid of phenolic compounds other than volatile phenols. Therefore, an ageing period in the wooden barrel is required to attain sensory fullness and high quality. During this process, several phenomena take place, namely the release of low molecular weight phenolic compounds and tannins from the wood into the wine spirit. Research conducted over the last decades shows that they play a decisive role on the physicochemical characteristics and relevant sensory properties of the beverage. Their contribution to the antioxidant activity has also been emphasized. Besides, some studies show the modulating effect of the ageing technology, involving different factors such as the barrel features (including the wood botanical species, those imparted by the cooperage technology, and the barrel size, the cellar conditions, and the operations performed, on the phenolic composition and related properties of the aged wine spirit. This review aims to summarize the main findings on this topic, taking into account two featured barrel characteristics—the botanical species of the wood and the toasting level.

  9. 7 CFR 58.425 - Conveyor for moving and draining block or barrel cheese.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Conveyor for moving and draining block or barrel cheese. 58.425 Section 58.425 Agriculture Regulations of the Department of Agriculture (Continued... cheese. The conveyor shall be constructed so that it will not contaminate the cheese and be easily...

  10. 33 CFR 135.103 - Levy and payment of barrel fee on OCS oil.

    Science.gov (United States)

    2010-07-01

    ... SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Levy of Fees § 135.103 Levy and payment of barrel fee on OCS oil. (a) A fee of $.03 per... paragraph (a) of this section applies whenever the unobligated Fund balance is less than $200,000,000. (d...

  11. Analisa Aspek Ergonomi Di Restoran Pipe & Barrel Surabaya Terhadap Kenyamanan Karyawan Dan Konsumen

    OpenAIRE

    Soedarto, Feby Christabella; Widjaja, Anastasia Hendrayanti; Kristanti, Monika

    2016-01-01

    Penelitian ini dilakukan di Restoran Pipe & Barrel Surabaya, dengan tujuan untuk mengetahui apakah aspek ergonomi berpengaruh terhadap Kenyamanan karyawan dan konsumen. Penelitian ini mengambil sampel sebanyak 3 karyawan sebagai informan dan 100 konsumen sebagai responden. Penelitian ini menggunakan Analisa Faktor Konfirmatori untuk dimensi Kenyaman konsumen dan triangulasi untuk dimensi Kenyamanan karyawan. Berdasarkan hasil penelitian, diperoleh bahwa aspek ergonomi pada dimensi Kenyam...

  12. Test of the wire ageing induced by radiation for the CMS barrel muon chamber

    CERN Document Server

    Conti, Enrico

    2000-01-01

    We have carried out laboratory test to measure the ageing of a wire tube due to pollutant outgassed by various materials. The tested materials are those used in the muon barrel drift tubes. An X-ray gun irradiated the test tube to accelerate the ageing process. No ageing effect has been measured for a period equivalent to 10 years of operation at LHC.

  13. Morphometric Plasticity of Nitric Oxide Containing Neurons in the Barrel Cortex of De-whiskered Rats

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Afarinesh

    2015-04-01

    Full Text Available Background: The rodent somatosensory barrel cortex is an ideal model to examine the effect of experience-dependent plasticity on developing brain circuitry. Sensory deprivation such as whisker deprivation may affect neuroanatomical aspects of the brain during developmental processes. The present study designed to investigate the possible effects of whisker deprivation on the morphometric characteristics of NADPH-d positive neurons in the barrel field cortex of adolescent rats.Materials and Methods: Pups were divided into the intact (n=4 and whisker-deprived groups (n=4. In whisker-deprived group, the total whiskers of subjects were trimmed every other day from postnatal day (PND 0 to PND 60. NADPH-d histochemistry reaction was processed to quantitatively analyze the feature of NADPH-d containing neurons of barrel cortex.Results: Our results showed that the number of NADPH-d positive neurons remained unchanged in whisker-deprived group compared to controls. The mean soma diameter, dendritic length and the number of 3rd order processes were significantly decreased in the whisker-deprived rats (p<0.05.Conclusion: Our results indicate that postnatal whisker deprivation possibly alter NADPH-d/NOS neuronal features in the barrel cortex. The functional implications of these data may relate the plasticity of synaptic receptive field and developmental brain circuits.

  14. LED package with Dome/side-emitting-enhancement silicone lens achieved by dispensing and geometry transferring

    Science.gov (United States)

    Chang Chien, Chien-Lin; Huang, Yu-Che; Hu, Syue-Fong; Sun, Chang-Wen; Chang, Chung-Min; Hsu, Chih-Peng; Yip, Ming-Chuen; Fang, Weileun

    2012-10-01

    This study presents a structure design and process method for lens type LED package. Dome type or side-emitting-enhancement silicone lens without molding process are achieved. The ceramic ring is adopted as the confine for the encapsulant. The surface intension along the sidewall of ceramic ring and silicone surface, the cohesion force and the gravity of silicone determine the shape of dome type silicone lens. The cone shape tooling coated with a releasing material is immersed into the dome type silicone lens before the silicone fully hardening. After curing simultaneously, to remove the tooling from package, the package with side-emitting-enhancement silicone lens is finished. With the mentioned architecture and process, this LED package herein has three merits, (1) to improve light extraction efficiency: reduce the chance of total internal reflection by the geometry of dome type silicone lens. (2)To enhance the flexibility of LED package design, the die placement location would be constrained by the mold in the traditional package process. (3) Mold-less side-emitting-enhancement silicone lens. Furthermore, two types of cone shape tooling are implemented and compared for side-emitting-enhancement silicone lens. Measurement results show the ratio between the lens high and lens radius could achieve 0.9:1. The view angles of dome type and side-emitting-enhancement LED packaged devices can reach 153° and 180 °, respectively. As using the same brightness grade of LED chip, the luminous flux is increasing 15% as compared the dome type package with the commercial PLCC (Plastic Leaded Chip Carrier) type package. The luminous flux of side-emitting-enhancement LED package decreases 8% as compared with the dome type one.

  15. A wireline piston core barrel for sampling cohesionless sand and gravel below the water table

    Science.gov (United States)

    Zapico, Michael M.; Vales, Samuel; Cherry, John A.

    1987-01-01

    A coring device has been developed to obtain long and minimally disturbed samples of saturated cohesionless sand and gravel. The coring device, which includes a wireline and piston, was developed specifically for use during hollow-stem auger drilling but it also offers possibilities for cable tool and rotary drilling. The core barrel consists of an inner liner made of inexpensive aluminum or plastic tubing, a piston for core recovery, and an exterior steel housing that protects the liner when the core barrel is driven into the aquifer. The core barrel, which is approximately 1.6m (5.6 feet) long, is advanced ahead of the lead auger by hammering at the surface on drill rods that are attached to the core barrel. After the sampler has been driven 1.5m (5 feet), the drill rods are detached and a wireline is used to hoist the core barrel, with the sample contained in the aluminum or plastic liner, to the surface. A vacuum developed by the piston during the coring operation provides good recovery of both the sediment and aquifer fluids contained in the sediment. In the field the sample tubes can be easily split along their length for on-site inspection or they can be capped with the pore water fluids inside and transported to the laboratory. The cores are 5cm (2 inches) in diameter by 1.5m (5 feet) long. Core acquisition to depths of 35m (115 feet), with a recovery greater than 90 percent, has become routine in University of Waterloo aquifer studies. A large diameter (12.7cm [5 inch]) version has also been used successfully. Nearly continuous sample sequences from sand and gravel aquifers have been obtained for studies of sedimentology, hydraulic conductivity, hydrogeochemistry and microbiology.

  16. Performance analysis for the CALIFA Barrel calorimeter of the R{sup 3}B experiment

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez-Pol, H., E-mail: hector.alvarez@usc.es [Dpt. de Física de Partículas, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); Ashwood, N. [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Aumann, T. [Institut für Kernphysik, Technische Universität Darmstadt, D-64289 Darmstadt (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Bertini, D. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Cabanelas, P. [Dpt. de Física de Partículas, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); Casarejos, E. [Universidade de Vigo, E-36310 Vigo (Spain); Cederkall, J. [Department of Physics, Lund University, SE 221 00 Lund (Sweden); Cortina-Gil, D.; Díaz Fernández, P.; Duran, I. [Dpt. de Física de Partículas, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); Fiori, E. [ExtreMe Matter Institute EMMI and Research Division, GSI Helmholtzzentrum für Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Frankfurt Institute for Advanced Studies, D-60438 Frankfurt am Main (Germany); Galaviz, D. [Centro de Fsica Nuclear da Universidade de Lisboa, 1649-003 Lisbon (Portugal); Labiche, M. [STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom); Nacher, E. [Instituto de Estructura de la Materia CSIC, Madrid (Spain); Pietras, B. [Dpt. de Física de Partículas, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); and others

    2014-12-11

    The CALIFA calorimeter is an advanced detector for gamma rays and light charged particles, accordingly optimized for the demanding requirements of the physics programme proposed for the R{sup 3}B facility at FAIR. The multipurpose character of CALIFA is required to fulfil challenging demands in energy resolution (5–6% at 1 MeV for gamma rays) and efficiency. Charged particles, e.g. protons of energies up to 320 MeV in the Barrel section, should also be identified with an energy resolution better to 1%. CALIFA is divided into two well-separated sections: a “Forward EndCap” and a cylindrical “Barrel” covering an angular range from 43.2° to 140.3°. The Barrel section, based on long CsI(Tl) pyramidal frustum crystals coupled to large area avalanche photodiodes (LAAPDs), attains the requested high efficiency for calorimetric purposes. The construction of the CALIFA Demonstrator, comprising 20% of the total detector, has already been initiated, and commissioning experiments are expected for 2014. The assessment of the capabilities and expected performance of the detector elements is a crucial step in their design, along with the prototypes evaluation. For this purpose, the Barrel geometry has been carefully implemented in the simulation package R3BRoot, including easily variable thicknesses of crystal wrapping and carbon fibre supports. A complete characterization of the calorimeter response (including efficiency, resolution, evaluation of energy and reconstruction losses) under different working conditions, with several physics cases selected to probe the detector performance over a wide range of applications, has been undertaken. Prototypes of different sections of the CALIFA Barrel have been modeled and their responses have been evaluated and compared with the experimental results. The present paper summarizes the outcome of the simulation campaign for the entire Barrel section and for the corresponding prototypes tested at different European installations.

  17. Primary intraocular lens implantation for penetrating lens trauma in Africa.

    Science.gov (United States)

    Bowman, R J; Yorston, D; Wood, M; Gilbert, C; Foster, A

    1998-09-01

    This study aimed to audit the surgical strategy of primary posterior chamber intraocular lens implantation for cases of recent penetrating trauma involving the lens in an African population. Retrospective, noncomparative case series. Seventy-two cases are reported, including all patients who underwent primary intraocular lens implantation for traumatic cataract extraction performed within 1 month of injury between 1988 and 1996. Demographic characteristics and follow-up attendance rates are analyzed. Surgical technique and the occurrence of intraoperative and postoperative complications are reported. Visual outcomes are reported with detailed analysis for cases of poor visual outcome. Mean age was 14.3 years (standard deviation = 11.1), 57 (79%) were male and 15 (21%) were female (chi-square = 23.66, P capsule had been breached by the trauma in 27 (38%) cases, and 15 of these required anterior vitrectomy. Capsular fixation of the implant was achieved in 49% of patients, the remainder having sulcus fixation. Intraoperative rupture of the posterior capsule occurred in four cases. The only common postoperative complication was acute fibrinous anterior uveitis, which occurred in 29 (40%) patients, and 32% of patients followed up for at least 6 months required secondary posterior capsulotomy. This was more common in younger patients (chi-square = 4.2, P < 0.05). Corrected postoperative visual acuities were available for 51 patients, of which 71% achieved 20/60 or better visual acuity. Patients 6 years of age or younger were less likely to achieve 20/60 (chi-square = 6.61, P = 0.01). This surgical strategy has proved successful, producing good visual results and causing no sight-threatening complications. Primary posterior capsulotomy may be appropriate for younger patients.

  18. X-ray effects of lens DNA-implications of superoxide (O2.-)

    International Nuclear Information System (INIS)

    Srivastava, V.K.; Richards, R.D.; Varma, S.D.

    1983-01-01

    The photocemical generation of superoxide (O 2 .-) during in vitro exposure of bovine lenses induced damage in the structure of lens DNA as indicated by hyperchromicity and Tm measurements. The damage in lens DNA was significantly protected by the inclusion of superoxide dismutase (SOD), glutathione (GSH) and ascorbate in the incubation medium before X-ray exposure. The protection by SOD, GSH and ascorbate occurred due to their interaction with O 2 .- radicals. These results thus indicate the deleterious effect of O 2 .- in lens physiology and the protective role of such compounds against radiation damage. (author)

  19. Research on one manual zoom liquid lens

    Science.gov (United States)

    Zhao, Cunhua; Shi, Yongpeng; Li, Wenjiao; Li, Congcong

    2011-11-01

    In liquid zoom lens, the accurate fixed-focus location needs the accurate calculation of focal length. That is to say, the accurate calculation of surface curvature must be obtained. Therefore, the research of their relation in liquid zoom lens becomes extremely important which has a directly theoretical instruction for the design of liquid zoom lenses. In our paper, the relation is studied. A manual liquid lens is reported which has upper and nether components with specificaton Φ12×5mm. The zoom lens is obtained by the upper component circumvolving down into the nether components.

  20. Exchange of tears under a contact lens is driven by distortions of the contact lens.

    Science.gov (United States)

    Maki, Kara L; Ross, David S

    2014-12-01

    We studied the flow of the post-lens tear film under a soft contact lens to understand how the design parameters of contact lenses can affect ocular health. When a soft contact lens is inserted, the blinking eyelid causes the lens to stretch in order to conform to the shape of the eye. The deformed contact lens acts to assume its un-deformed shape and thus generates a suction pressure in the post-lens tear film. In consequence, the post-lens tear fluid moves; it responds to the suction pressure. The suction pressure may draw in fresh fluid from the edge of the lens, or it may eject fluid there, as the lens reassumes its un-deformed shape. In this article, we develop a mathematical model of the flow of the post-lens tear fluid in response to the mechanical suction pressure of a deformed contact lens. We predict the amount of exchange of fluid exchange under a contact lens and we explore the influence of the eye's shape on the rate of exchange of fluid. © The Author 2014. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

  1. Symmetrical optical imaging system with bionic variable-focus lens for off-axis aberration correction

    Science.gov (United States)

    Wang, Xuan-Yin; Du, Jia-Wei; Zhu, Shi-Qiang

    2017-09-01

    A bionic variable-focus lens with symmetrical layered structure was designed to mimic the crystalline lens. An optical imaging system based on this lens and with a symmetrical structure that mimics the human eye structure was proposed. The refractive index of the bionic variable-focus lens increases from outside to inside. The two PDMS lenses with a certain thickness were designed to improve the optical performance of the optical imaging system and minimise the gravity effect of liquid. The paper presents the overall structure of the optical imaging system and the detailed description of the bionic variable-focus lens. By pumping liquid in or out of the cavity, the surface curvatures of the rear PDMS lens were varied, resulting in a change in the focal length. The focal length range of the optical imaging system was 20.71-24.87 mm. The optical performance of the optical imaging system was evaluated by imaging experiments and analysed by ray tracing simulations. On the basis of test and simulation results, the optical performance of the system was quite satisfactory. Off-axis aberrations were well corrected, and the image quality was greatly improved.

  2. Imaging off-plane shear waves with a two-dimensional phononic crystal lens

    International Nuclear Information System (INIS)

    Chiang Chenyu; Luan Pigang

    2010-01-01

    A two-dimensional flat phononic crystal (PC) lens for focusing off-plane shear waves is proposed. The lens consists of a triangular lattice hole-array, embedded in a solid matrix. The self-collimation effect is employed to guide the shear waves propagating through the lens along specific directions. The Dirichlet-to-Neumann maps (DtN) method is employed to calculate the band structure of the PC, which can avoid the problems of bad convergence and fake bands automatically in the void-solid PC structure. When the lens is illuminated by the off-plane shear waves emanating from a point source, a subwavelength image appears in the far-field zone. The imaging characteristics are investigated by calculating the displacement fields explicitly using the multiple scattering method, and the results are in good agreement with the ray-trace predictions. Our results may provide insights for designing new phononic devices.

  3. Effect of oak wood barrel capacity and utilization time on phenolic and sensorial profile evolution of an Encruzado white wine.

    Science.gov (United States)

    Nunes, Paulo; Muxagata, Sara; Correia, Ana C; Nunes, Fernando M; Cosme, Fernanda; Jordão, António M

    2017-11-01

    Several studies have reported the influence of diverse winemaking technologies in white wine characteristics. However, the impact of the use of different oak wood barrel capacities and utilization time on the evolution of white wine phenolic content and sensorial characteristics are not usually considered. Thus the aim of this work was to evaluate the effect of oak wood barrel capacity and utilization time on the evolution of phenolic compounds, browning potential index and sensorial profile of an Encruzado white wine. For the 180 aging days considered, the use of new oak wood barrels induced a greater increase in global phenolic composition, including several individual compounds, such as gallic and ellagic acid, independently of the barrel capacity. Tendency for a lesser increase of the browning potential index values was detected for white wines aged in new oak wood barrels. The sensorial profile evolution, showed significant differences only for the aroma descriptors, namely for 'wood aroma' and 'aroma intensity', white wine aged in 225 L new oak wood barrels being the highest scored. The results show that, in general, the use of different capacities and utilization time of oak wood barrels used for white wine aging could play an important role in white wine quality. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  4. Fabrication of polycrystalline diamond refractive X-ray lens by femtosecond laser processing

    Energy Technology Data Exchange (ETDEWEB)

    Kononenko, T.V.; Ralchenko, V.G.; Ashkinazi, E.E.; Konov, V.I. [General Physics Institute of Russian Academy of Sciences, Moscow (Russian Federation); National Research Nuclear University ' ' MEPhI' ' , Moscow (Russian Federation); Polikarpov, M.; Ershov, P. [Immanuel Kant Baltic Federal University, Functional Nanomaterials, Kaliningrad (Russian Federation); Kuznetsov, S.; Yunkin, V. [Institute of Microelectronics Technology RAS, Chernogolovka, Moscow region (Russian Federation); Snigireva, I. [European Synchrotron Radiation Facility, Grenoble (France)

    2016-03-15

    X-ray planar compound refractive lenses were fabricated from a polycrystalline diamond plate grown by chemical vapor deposition, by precise through cutting with femtosecond laser pulses. The lens geometry and the surface morphology were investigated with optical and scanning electron microscopy, while the material structure modification was analyzed by Raman spectroscopy. The results of the preliminary lens test at 9.25-keV X-rays are presented. (orig.)

  5. Fabrication of polycrystalline diamond refractive X-ray lens by femtosecond laser processing

    International Nuclear Information System (INIS)

    Kononenko, T.V.; Ralchenko, V.G.; Ashkinazi, E.E.; Konov, V.I.; Polikarpov, M.; Ershov, P.; Kuznetsov, S.; Yunkin, V.; Snigireva, I.

    2016-01-01

    X-ray planar compound refractive lenses were fabricated from a polycrystalline diamond plate grown by chemical vapor deposition, by precise through cutting with femtosecond laser pulses. The lens geometry and the surface morphology were investigated with optical and scanning electron microscopy, while the material structure modification was analyzed by Raman spectroscopy. The results of the preliminary lens test at 9.25-keV X-rays are presented. (orig.)

  6. Optomechanical integrated simulation of Mars medium resolution lens with large field of view

    Science.gov (United States)

    Yang, Wenqiang; Xu, Guangzhou; Yang, Jianfeng; Sun, Yi

    2017-10-01

    The lens of Mars detector is exposed to solar radiation and space temperature for long periods of time during orbit, so that the ambient temperature of the optical system is in a dynamic state. The optical and mechanical change caused by heat will lead to camera's visual axis drift and the wavefront distortion. The surface distortion of the optical lens includes the displacement of the rigid body and the distortion of the surface shape. This paper used the calculation method based on the integrated optomechanical analysis, to explore the impact of thermodynamic load on image quality. Through the analysis software, established a simulation model of the lens structure. The shape distribution and the surface characterization parameters of the lens in some temperature ranges were analyzed and compared. the PV / RMS value, deformation cloud of the lens surface and quality evaluation of imaging was achieved. This simulation has been successfully measured the lens surface shape and shape distribution under the load which is difficult to measure on the experimental conditions. The integrated simulation method of the optical machine can obtain the change of the optical parameters brought by the temperature load. It shows that the application of Integrated analysis has play an important role in guiding the designing the lens.

  7. Changes of enzyme activities in lens after glaucoma trabecular resection

    Directory of Open Access Journals (Sweden)

    Jian-Ping Wang

    2013-08-01

    Full Text Available AIM: To observe the change of lens antioxidant enzyme activity after glaucoma trabecular resection. METHODS: Thirty-two eyes of sixteen New-Zealand rabbits(2.2-2.4kgwere divided into two groups. The left eyes of rabbits underwent standard glaucoma trabecular resection were treatment group, and the normal right eyes served as controls. Transparency of lenses was monitored by a slit-lamp biomicroscopy before and after glaucoma trabecular resection. The morphology of lens cells was observed under the light microscope.The activities of Na+-K+-ATPase,catalase(CAT, glutathion peroxidase(GSH-px, glutathione reductase(GR, superoxide dismutase(SODand content of malondialdehyde(MDAin lenses were detected six months after trabecular resection. RESULTS: Lenses were clear in both treatment group and normal control group during the six months after operation. The morphology and structure of lens cells were normal under the light microscope in both operation group and normal group. The activity of lens cells antioxidant enzyme activity were significantly decreased in operation group compared with control group, Na+-K+-ATPase declined by 20.97%, CAT declined by 16.36%, SOD declined by 4.46%, GR declined by 4.85%, GSH-px declined by 10.02%, and MDA increased by 16.31%. CONCLUSION: Glaucoma trabecular resection can induce the change of Na+-K+-ATPase, CAT, GSH-px, GR, SOD and MDA in lens of rabbit. Glaucoma filtration surgery for the occurrence of cataract development mechanism has important guiding significance.

  8. Quantitative/Statistical Approach to Bullet-to-Firearm Identification with Consecutively Manufactured Barrels

    Energy Technology Data Exchange (ETDEWEB)

    Peter Striupaitis; R.E. Gaensslen

    2005-01-30

    Efforts to use objective image comparison and bullet scanning technologies to distinguish bullets from consecutively manufactured handgun barrels from two manufacturers gave mixed results. The ability of a technology to reliably distinguish between matching and non-matching bullets, where the non-matching bullets were as close in pattern to the matching ones as is probably possible, would provide evidence that the distinctions could be made ''objectively'', and independently of human eyes. That evidence is identical or very close to what seems to be needed to satisfy Daubert standards. It is fair to say that the FTI IBIS image comparison technology correctly distinguished between all the Springfield barrel bullets, and between most but not all of the HiPoint barrel bullets. In the HiPoint cases that were not distinguished 100% of the time, they would he distinguished correctly at least 83% of the time. These results, although obviously limited to the materials used in the comparisons, provide strong evidence that barrel-to-bullet matching is objectively reliable. The results with SciClops were less compelling. The results do not mean that bullet-to-barrel matching is not objectively reliable--rather, they mean that this version of the particular technology could not quite distinguish between these extremely similar yet different bullets as well as the image comparison technology did. In a number of cases, the numerical results made the correct distinctions, although they were close to one another. It is hard to say from this data that this technology differs in its ability to make distinctions between the manufacturers, because the results are very similar with both. The human examiner results were as expected. We did not expect any misidentifications, and there were not any. It would have been preferable to have a higher return rate, and thus more comparisons in the overall sample. As noted, the ''consecutively manufactured barrel

  9. [Acanthamoeba isolation from contact lens solution of contact lens wearers without keratitis].

    Science.gov (United States)

    Watanabe, R; Ishibashi, Y; Hommura, S; Ishii, K

    1994-05-01

    Acanthamoeba keratitis seems to be associated with wearing contact lenses. As controls, we surveyed contact lens wearers without keratitis. Contact lens solutions of 93 persons were examined in order to identify risk factors for contamination by Acanthamoeba. Therefore, the contact lens disinfection system and storage schedules were studied in each case. Acanthamoeba organisms were isolated from 4 specimens (4.3%). The incidence of Acanthamoeba was higher in specimens of soft contact lens solution than in those of hard contact lens solution, and all the Acanthamoeba positive cases had been using tap water.

  10. Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation.

    Science.gov (United States)

    Hoffman, Richard S; Fine, I Howard; Packer, Mark

    2009-10-01

    Subluxated cataractous and clear lenses are commonly treated by limbal or pars plana lensectomy followed by primary or secondary intraocular lens (IOL) implantation. Adjunctive capsular prosthetic devices have facilitated lens removal and IOL centration in these challenging cases but have also added complexity and potential complications to the procedure. Although crystalline lens extraction may be required to clear the visual axis in mild to moderate lens subluxations, we propose insertion of a primary anterior chamber IOL without lens extraction in severe subluxations when the eye is optically aphakic or can be made functionally aphakic following neodymium:YAG laser zonulysis. Two cases demonstrating this approach are presented.

  11. SiPM photosensors and fast timing readout for the Barrel Time-of-Flight detector in bar PANDA

    Science.gov (United States)

    Suzuki, K.

    2018-03-01

    The Barrel Time-of-Flight detector system will be installed in the upcoming bar PANDA experiment at FAIR in Germany. The detector has a barrel shape of phi=0.5 m and 1.8 m long, covering about 5 m2, which corresponds to the laboratory polar angle coverage of 22oPANDA Barrel Time-of-Flight detector are presented. The test shows that the current design fulfils satisfactorily the required timing performance (σt~ 56 ps) and the timing performance depends little on the hit position on the surface.

  12. Protection of the eye lens

    International Nuclear Information System (INIS)

    2015-01-01

    The limit of radiation exposure for eye lens is going to decrease dramatically from 150 to 20 mSv as a transposition into the French law of a CIPR (International Commission for Radiation Protection) directive. Sanitary studies have shown that radiologists are more likely by a factor of 3.8 to get eye lens opacities than the rest of the population. The wearing of protective glasses is recommended and in order to get a better monitoring of the radiation dose new dosimeters have been designed, they can be worn on the glass frame of directly stuck on the skin near the eyes. A study has shown that veterinary surgeons that are accustomed to stay near animals to keep them quiet during radiological exams are prone to receive high doses as well as physicians that use hypnosis to decrease the level of anxiety of their patients during radiological exams. Radiation exposure of radiologists can be mitigated through: the use of protective shields and equipment and the optimization of the dose delivered to the patient. (A.C.)

  13. Color corrected Fresnel lens for solar concentration

    International Nuclear Information System (INIS)

    Kritchman, E.M.

    1979-01-01

    A new linear convex Fresnel lens with its groove side down is described. The design philosophy is similar to the highly concentrating two focal Fresnel lens but including a correction for chromatic aberration. A solar concentration ratio as high as 80 is achieved. For wide acceptance angles the concentration nears the theoretical maximum. (author)

  14. Charged black lens in de Sitter space

    Science.gov (United States)

    Tomizawa, Shinya

    2018-02-01

    We obtain a charged black lens solution in the five-dimensional Einstein-Maxwell-Chern-Simons theory with a positive cosmological constant. It is shown that the solution obtained here describes the formation of a black hole with the spatial cross section of a sphere from that of the lens space of L (n ,1 ) in five-dimensional de Sitter space.

  15. Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life.

    Directory of Open Access Journals (Sweden)

    Niels Lynnerup

    Full Text Available BACKGROUND: Lens crystallines are special proteins in the eye lens. Because the epithelial basement membrane (lens capsule completely encloses the lens, desquamation of aging cells is impossible, and due to the complete absence of blood vessels or transport of metabolites in this area, there is no subsequent remodelling of these fibers, nor removal of degraded lens fibers. Human tissue ultimately derives its (14C content from the atmospheric carbon dioxide. The (14C content of the lens proteins thus reflects the atmospheric content of (14C when the lens crystallines were formed. Precise radiocarbon dating is made possible by comparing the (14C content of the lens crystallines to the so-called bomb pulse, i.e. a plot of the atmospheric (14C content since the Second World War, when there was a significant increase due to nuclear-bomb testing. Since the change in concentration is significant even on a yearly basis this allows very accurate dating. METHODOLOGY/PRINCIPAL FINDINGS: Our results allow us to conclude that the crystalline formation in the lens nucleus almost entirely takes place around the time of birth, with a very small, and decreasing, continuous formation throughout life. The close relationship may be further expressed as a mathematical model, which takes into account the timing of the crystalline formation. CONCLUSIONS/SIGNIFICANCE: Such a life-long permanence of human tissue has hitherto only been described for dental enamel. In confront to dental enamel it must be held in mind that the eye lens is a soft structure, subjected to almost continuous deformation, due to lens accommodation, yet its most important constituent, the lens crystalline, is never subject to turnover or remodelling once formed. The determination of the (14C content of various tissues may be used to assess turnover rates and degree of substitution (for example for brain cell DNA. Potential targets may be nervous tissues in terms of senile or pre

  16. Conceptual design report for the SDC barrel and intermediate muon detectors based on a jet-type drift chamber

    International Nuclear Information System (INIS)

    Arai, Y.; Funahashi, Y.; Higashi, Y.

    1992-04-01

    We propose a jet-type drift chamber for the barrel and intermediate muon detectors of SDC. The chamber system consists of large multiwire drift chambers having a simple box-type frame structure: 2. 5 x 0.4 m 2 in cross section and maximum 9 m in length. A chamber module consists of double layers of small jet cells. The drift cell is composed of a wire plane, including 3 sense wires, and cathode plates parallel to the wire plane. The two layers in a chamber are staggered to each other by half a cell width. The jet cell is tilted such that its principle axis points to the interaction point. Such an arrangement, together with a constant drift velocity of the jet cell, allows us to design a simple and powerful trigger system for high momentum muons utilizing a drift time sum between a pair of staggered cells. The multi-hit capability will be helpful to distinguish high momentum muon tracks from associated electromagnetic debris as has been demonstrated by the Fermilab beam test T816. The maximum drift time fulfills the SDC requirement. A preliminary FEM analysis of the chamber module verified the excellent structural stiffness. It makes the support structure and the alignment system relatively simple. These features will reduce the total cost as well as ensure a good performance of the chamber system. (J.P.N.)

  17. Contact Lens Use in the Civil Airman Population

    National Research Council Canada - National Science Library

    Nakagawara, Van

    2002-01-01

    ...) aeromedical certificate. Although contact lens technology has advanced dramatically in recent years, the aviation environment may still have adverse effects on contact lens performance in some flight situations...

  18. Prototype Strip Barrel Modules for the ATLAS ITk Strip Detector

    CERN Document Server

    Sawyer, Craig; The ATLAS collaboration

    2017-01-01

    The module design for the Phase II Upgrade of the new ATLAS Inner Tracker (ITk) detector at the LHC employs integrated low mass assembly using single-sided flexible circuits with readout ASICs and a powering circuit incorporating control and monitoring of HV, LV and temperature on the module. Both readout and powering circuits are glued directly onto the silicon sensor surface resulting in a fully integrated, extremely low radiation length module which simultaneously reduces the material requirements of the local support structure by allowing a reduced width stave structure to be employed. Such a module concept has now been fully demonstrated using so-called ABC130 and HCC130 ASICs fabricated in 130nm CMOS technology to readout ATLAS12 n+-in-p silicon strip sensors. Low voltage powering for these demonstrator modules has been realised by utilising a DCDC powerboard based around the CERN FEAST ASIC. This powerboard incorporates an HV multiplexing switch based on a Panasonic GaN transistor. Control and monitori...

  19. Corrected electrostatic lens systems for ion beams

    International Nuclear Information System (INIS)

    Dalgish, R.L.

    1981-01-01

    Recent work in our laboratory has introduced a new class of electrostatic focus forming element for beams, the ELCO lens. It compares favourably with the electrostatic and magnetic quadrupole elements conventionally used for microbeam formation. The ELCO lens does however have disadvantages associated with apertures and alignment. We have continued with the development of ion beam lenses and have evolved a further class of lens element which eliminates aperture and alignment problems. This new element can be combined like optical lenses into an aberration corrected system. Experimental measurement on the basic lens element has confirmed mathematical analysis of ion trajectories through the element. This mathematical analysis predicts that the basic element can be combined into a corrected lens system for, either: (1) high resolution microprobe formation with intrinsic rastering ability, the spot size limited only by the beam properties; or (2) high quality image formation with large magnification/demagnification ratio and wide angular aperture. (orig.)

  20. A patient with a traumatic brain injury due to barrel bomb tertiary blast effect

    Directory of Open Access Journals (Sweden)

    Mustafa Bolatkale

    2017-06-01

    Full Text Available Preparing to manage weapons of mass destruction events challenges emergency services systems neighboring Syria every day. Understanding injury from explosives is essential for all providers of emergency care in both civilian and military settings. In this case, the authors present a 22-year-old man who was admitted to the emergency department with displaced skull fracture, epidural hemorrhage and cerebral contusion due to barrel bomb tertiary blast effect. A 22-year-old man who complained of pain in the right temporal head region after barrel bomb explosion was admitted in the emergency department. The patient could not remember the explosion and found himself on the ground. In his medical history, there was not a record of any diseases, operations or traumas. Examination of the head revealed scalp hematoma and slump in the skull on the right temporal region. Patients computed tomography (CT scan showed a displaced skull fracture, epidural hematoma and cerebral contusion.

  1. Intercalibration of the barrel electromagnetic calorimeter of the CMS experiment at start-up

    CERN Document Server

    Adzic, Petar; Almeida, Nuno; Anagnostou, Georgios; Andelin, Daniel; Anfreville, Marc; Anicin, Ivan; Antunovic, Zeljko; Arcidiacono, Roberta; Arenton, Michael Wayne; Auffray, Etiennette; Argiro, Stefano; Askew, Andrew; Atramentov, Oleksiy; Baccaro, Stefania; Baffioni, Stephanie; Balazs, Michael; Barney, David; Barone, Luciano; Bartoloni, Alessandro; Baty, Clement; Bandurin, Dmitry; Beauceron, Stephanie; Bell, Ken W; Benetta, Robert; Bercher, Michel; Bernet, Colin; Berthon, Ursula; Besançon, Marc; Betev, Botjo; Beuselinck, Raymond; Biino, Cristina; Blaha, Jan; Bloch, Philippe; Blyth, Simon; Bornheim, Adolf; Bourotte, Jean; Brett, Angela Mary; Brown, Robert M; Britton, David; Bühler, M; Busson, Philippe; Camanzi, Barbara; Camporesi, Tiziano; Carrera, E; Cartiglia, Nicolo; Cavallari, Francesca; Cerutti, Muriel; Chang, Paoti; Chang, You-Hao; Charlot, Claude; Chen, E Augustine; Chen, Wan-Ting; Chen, Zheng-Yu; Chipaux, Rémi; Choudhary, Brajesh C; Choudhury, Rajani Kant; Cockerill, David J A; Combaret, Christophe; Conetti, Sergio; Cossutti, Fabio; Cox, Bradley; Cussans, David; Dafinei, Ioan; Da Silva Di Calafiori, Diogo Raphael; Daskalakis, Georgios; Davatz, Giovanna; David, A; Deiters, Konrad; Dejardin, Marc; Djordjevic, Milos; Della Negra, Rodolphe; Della Ricca, Giuseppe; Del Re, Daniele; De Min, Alberto; Denegri, Daniel; Depasse, Pierre; Descamps, Julien; Diemoz, Marcella; Di Marco, Emanuele; Dissertori, Günther; Dittmar, Michael; Djambazov, Lubomir; Dobrzynski, Ludwik; Drndarevic, Snezana; Duboscq, Jean Etienne; Dutta, Dipanwita; Dzelalija, Mile; Peisert, A; El-Mamouni, H; Evangelou, Ioannis; Evans, David; Fabbro, Bernard; Faure, Jean-Louis; Fay, Jean; Ferri, Federico; Flower, Paul S; Franci, Daniele; Franzoni, Giovanni; Freudenreich, Klaus; Funk, Wolfgang; Ganjour, Serguei; Gargiulo, Corrado; Gascon, Susan; Gataullin, Marat; Geerebaert, Yannick; Gentit, François-Xavier; Gershtein, Yuri; Ghezzi, Alessio; Ghodgaonkar, Manohar; Gilly, Jean; Givernaud, Alain; Gninenko, Sergei; Go, Apollo; Gobbo, Benigno; Godinovic, Nikola; Golubev, Nikolai; Gong, Datao; Govoni, Pietro; Grant, Nicholas; Gras, Philippe; Greenhalgh, R J S; Guevara Riveros, Luz; Guillaud, Jean-Paul; Haguenauer, Maurice; Hamel de Monchenault, Gautier; Hansen, Magnus; Heath, Helen F; Heltsley, Brian; Hill, Jack; Hintz, Wieland; Hirosky, Robert; Hobson, Peter R; Honma, Alan; Hou, George Wei-Shu; Hsiung, Yee; Husejko, Michal; Ille, Bernard; Imlay, Richard; Ingram, Quentin; Jarry, Patrick; Jessop, Colin; Jovanovic, Dragoslav; Kaadze, Ketino; Kachanov, Vassili; Kailas, Swaminathan; Kataria, Sushil Kumar; Kennedy, Bruce W; Kloukinas, Kostas; Kokkas, Panagiotis; Kolberg, Ted; Krasnikov, Nikolai; Krpic, Dragomir; Kubota, Yuichi; Kumar, P; Kuo, Chen-Cheng; Kyberd, Paul; Kyriakis, Aristotelis; Lebeau, Michel; Lecomte, Pierre; Lecoq, Paul; Ledovskoy, Alexander; Leshev, Georgi; Lethuillier, Morgan; Lin, Sheng-Wen; Lin, Willis; Lintern, A L; Litvine, Vladimir; Locci, Elizabeth; Lodge, Anthony B; Longo, Egidio; Loukas, Demetrios; Luckey, Paul David; Lustermann, Werner; Lynch, Clare; Ma, Yousi; Mahlke-Krüger, H; Malberti, Martina; Malcles, Julie; Maletic, Dimitrije; Mandjavidze, Irakli; Manthos, Nikolaos; Maravin, Yurii; Marchica, Carmelo; Marinelli, Nancy; Markou, Athanasios; Markou, Christos; Marone, Matteo; Mathez, Hervé; Matveev, Viktor; Mavrommatis, Charalampos; Maurelli, Georges; Meridiani, Paolo; Milenovic, Predrag; Milleret, Gérard; Miné, Philippe; Mohanty, Ajit Kumar; Moortgat, Filip; Mur, Michel; Musella, Pasquale; Musienko, Yuri; Nardulli, Alessandro; Nash, Jordan; Nédélec, Patrick; Negri, Pietro; Newman, Harvey B; Nikitenko, Alexander; Nessi-Tedaldi, Francesca; Obertino, Maria Margherita; Organtini, Giovanni; Orimoto, Toyoko; Paganoni, Marco; Paganini, Pascal; Palma, Alessandro; Panev, Bozhidar; Pant, Lalit Mohan; Papadakis, Antonakis; Papadakis, Ioannis; Papadopoulos, Ioannis; Paramatti, Riccardo; Parracho, P; Pastrone, Nadia; Patterson, Juliet Ritchie; Pauss, Felicitas; Petrakou, Eleni; Phillips, D G; Piroué, Pierre; Ptochos, Fotios; Puljak, Ivica; Pullia, Antonino; Punz, Thomas; Puzovic, Jovan; Ragazzi, Stefano; Rahatlou, Shahram; Rander, John; Razis, Panos A; Redaelli, Nicola; Renker, Dieter; Reucroft, Steve; Reymond, Jean-Marc; Ribeiro, Pedro Quinaz; Röser, Ulf; Rogan, Christopher; Romanteau, Thierry; Rondeaux, Françoise; Ronquest, Michael; Rosowsky, André; Rovelli, Chiara; Rumerio, Paolo; Rusack, Roger; Rusakov, Sergey V; Ryan, Matthew John; Sala, Leonardo; Salerno, Roberto; Santanastasio, Francesco; Schinzel, Dietrich; Seez, Christopher; Sharp, Peter; Shepherd-Themistocleous, Claire; Siamitros, Christos; Sillou, Daniel; Singovsky, Alexander; Sirois, Yves; Sirunyan, Albert M; Silva, J; Silva, Pedro; Shiu, Jing-Ge; Shivpuri, Ram Krishen; Shukla, Prashant; Smith, Brian; Smith, Vincent J; Sproston, Martin; Stöckli, Fabian; Suter, Henry; Swain, John; Tabarellide Fatis, T; Takahashi, Maiko; Tcheremoukhine, Alexandre; Teller, Olivier; Theofilatos, Konstantinos; Thiebaux, Christophe; Timciuc, Vladlen; Timlin, Claire; Titov, Maksym; Tobias, A; Topkar, Anita; Triantis, Frixos A; Troshin, Sergey; Tyurin, Nikolay; Ueno, Koji; Uzunian, Andrey; Varela, Joao; Verrecchia, Patrice; Veverka, Jan; Vichoudis, Paschalis; Virdee, Tejinder; Vlassov, E; Von Gunten, Hans Peter; Wang, Minzu; Wardrope, David; Weber, Markus; Weng, Joanna; Williams, Jennifer C; Yang, Yong; Yaselli, Ignacio; Yohay, Rachel; Zabi, Alexandre; Zamiatin, Nikolai; Zelepoukine, Serguei; Zhang, Jia-Wen; Zhang, Lin; Zhu, Kejun; Zhu, Ren-Yuan

    2008-01-01

    Calibration of the relative response of the individual channels of the barrel electromagnetic calorimeter of the CMS detector was accomplished before installation with cosmic ray muons and test beams. One fourth of the calorimeter was exposed to a beam of high energy electrons and the relative calibration of the channels, the intercalibration, was found to be reproducible to a precision of about 0.3\\%. Additionally, data were collected with cosmic rays for the entire ECAL barrel during the commissioning phase. By comparing the intercalibration constants obtained with the electron beam data with those from the cosmic ray data, it is demonstrated that the latter provide an intercalibration precision of 1.5\\% over most of the ECAL. The best intercalibration precision is expected to come from the analysis of events collected {\\it in situ} during the LHC operation. Using data collected with both electrons and pion beams, several aspects of the intercalibration procedures based on electrons or neutral pions were in...

  2. Current Status of the Pixel Phase I Upgrade in CMS: Barrel Module Production

    CERN Document Server

    Bartek, Rachel

    2016-01-01

    The silicon pixel detector is the innermost component of the CMS tracking system, providing high precision space point measurements of charged particle trajectories. Before 2018 the instantaneous luminosity of the LHC is expected to reach about 2~x~$10^{34}~\\rm{cm}^{-2}\\rm{s}^{-1}$, which will significantly increase the number of interactions per bunch crossing. To maintain a high tracking efficiency, CMS has planned to replace the current pixel system during phase I by a new lightweight detector, equipped with an additional 4th layer in the barrel, and one additional forward/backward disk. The present status of barrel modules production will be presented, including preliminary results from tests on the first production pixel modules of the new pixel tracker.

  3. A Barrel IFR Instrumented With Limited Streamer Tubes for BABAR Experiment

    International Nuclear Information System (INIS)

    Andreotti, M.; Ferrara U.; INFN, Ferrara

    2006-01-01

    The new barrel Instrumented Flux Return (IFR) of BABAR detector will be reported here. Limited Streamer Tubes (LSTs) have been chosen to replace the existing RPCs as active elements of the barrel IFR. The layout of the new detector will be discussed: in particular, a cell bigger than the standard one has been used to improve efficiency and reliability. The extruded profile is coated with a resistive layer of graphite having a typical surface resistivity between 0.2 and 0.4 MOhm/square. The tubes are assembled in modules and installed in 12 active layers of each sextant of the IFR detector. R and D studies to choose the final design and Quality Control procedure adopted during the tube production will be briefly discussed. Finally the performances of installed LSTs into 2/3 of IFR after 8 months of operations will be reported

  4. The CMS Barrel Calorimeter Response to Particle Beams from 2 to 350 GeV/c

    CERN Document Server

    Yazgan, Elfe

    2009-01-01

    The response of the combined CMS barrel calorimeters to hadrons, electrons and muons over a range from 2 to 350 GeV/$c$ has been measured. The analysis of the differences in calorimeter response to charged pions, kaons, protons and antiprotons and a discussion of the underlying phenomena are presented. Techniques to correct the signals from the considerably different electromagnetic (EB) and hadronic (HB) barrel calorimeters in reconstructing the energies of hadrons are also presented. Above 5 GeV/$c$, these corrections improve the energy resolution of the combined system where the stochastic term equals $84.7$\\% and the constant term is $7.4$\\%. The corrected mean response remains constant within 1.3\\% {\\it rms}.

  5. Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.

    Science.gov (United States)

    Weiler, Nicholas C; Collman, Forrest; Vogelstein, Joshua T; Burns, Randal; Smith, Stephen J

    2014-01-01

    A major question in neuroscience is how diverse subsets of synaptic connections in neural circuits are affected by experience dependent plasticity to form the basis for behavioral learning and memory. Differences in protein expression patterns at individual synapses could constitute a key to understanding both synaptic diversity and the effects of plasticity at different synapse populations. Our approach to this question leverages the immunohistochemical multiplexing capability of array tomography (ATomo) and the columnar organization of mouse barrel cortex to create a dataset comprising high resolution volumetric images of spared and deprived cortical whisker barrels stained for over a dozen synaptic molecules each. These dataset has been made available through the Open Connectome Project for interactive online viewing, and may also be downloaded for offline analysis using web, Matlab, and other interfaces.

  6. Test of CMS barrel muon drift chambers in high-radiation environment

    CERN Document Server

    Wegner, M

    2001-01-01

    Large-area prototypes of the CMS barrel muon chambers have been extensively investigated, especially at the "Gamma Irradiation Facility" at CERN, an experimental area which has been specifically constructed to test particle detectors in a muon beam in presence of a uniform high-rate irradiation. The dependence of chamber resolution and detection efficiency upon the background rate has been studied systematically. (5 refs).

  7. Influence of fuel vibration on PWR neutron noise associated with core barrel motion

    International Nuclear Information System (INIS)

    Sweeney, F.J.; March-Leuba, J.

    1984-01-01

    Ex-core neutron detector noise has been utilized to monitor core support barrel (CSB) vibrations. In order to observe long-term changes, noise signals at Sequoyah-1 were monitored continuously during the whole first fuel cycle and part of the second cycle. Results suggest that neutron noise measurements performed infrequently may not provide adequate surveillance of the CSB because it may be difficult to separate noise amplitude changes due solely to CSB motion from changes caused by fuel motion and burnup

  8. Altered somatosensory barrel cortex refinement in the developing brain of Mecp2-null mice.

    Science.gov (United States)

    Moroto, M; Nishimura, A; Morimoto, M; Isoda, K; Morita, T; Yoshida, M; Morioka, S; Tozawa, T; Hasegawa, T; Chiyonobu, T; Yoshimoto, K; Hosoi, H

    2013-11-06

    Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-CpG binding protein 2 (MeCP2) gene. In previous studies, monoaminergic dysfunctions have been detected in patients with RTT and in a murine model of RTT, the Mecp2-null mouse. Therefore, the pathogenesis of RTT is thought to involve impairments in the monoaminergic systems. However, there have been limited data showing that the impairment of monoamines leads to early symptoms during development. We used histochemistry to study the somatosensory barrel cortex in the B6.129P2(C)-Mecp2(tm1.1Bird) mouse model of RTT. The barrel cortex is widely used to investigate neuronal development and its regulation by various neurotransmitters including 5-HT. 5-HT levels were measured by high performance liquid chromatography with electrochemical detection (HPLC/EC), and serotonin transporter (SERT) and 5-HT1B receptor mRNAs were measured in the somatosensory cortex, thalamus and striatum on postnatal days (P) 10, P20 and P40. Mecp2-null mice (Mecp2-/y) had significantly smaller barrel fields than age-matched wild-type controls (Mecp2+/y) on P10 and P40, but the topographic map was accurately formed. Levels of 5-HT, and SERT and 5-HT1B receptor mRNA expression in the somatosensory cortex did not differ significantly between the Mecp2-null and wild-type mice on P10. However, thalamic 5-HT was reduced in Mecp2-null mice. Our data indicate that a lack of MeCP2 may disturb the refinement of the barrel cortex in the early postnatal period. Our findings suggest that a decrease in thalamic 5-HT might be involved in this phenomenon. © 2013 Elsevier B.V. All rights reserved.

  9. Brain-wide map of efferent projections from rat barrel cortex

    Directory of Open Access Journals (Sweden)

    Izabela M. Zakiewicz

    2014-02-01

    Full Text Available The somatotopically organized whisker barrel field of the rat primary somatosensory (S1 cortex is a commonly used model system for anatomical and physiological investigations of sensory processing. The neural connections of the barrel cortex have been extensively mapped. But most investigations have focused on connections to limited regions of the brain, and overviews in the literature of the connections across the brain thus build on a range of material from different laboratories, presented in numerous publications. Furthermore, given the limitations of the conventional journal article format, analyses and interpretations are hampered by lack of access to the underlying experimental data. New opportunities for analyses have emerged with the recent release of an online resource of experimental data consisting of collections of high-resolution images from 6 experiments in which anterograde tracers were injected in S1 whisker or forelimb representations. Building on this material, we have conducted a detailed analysis of the brain wide distribution of the efferent projections of the rat barrel cortex. We compare our findings with the available literature and reports accumulated in the Brain Architecture Management System (BAMS2 database. We report well-known and less known intracortical and subcortical projections of the barrel cortex, as well as distinct differences between S1 whisker and forelimb related projections. Our results correspond well with recently published overviews, but provide additional information about relative differences among S1 projection targets. Our approach demonstrates how collections of shared experimental image data are suitable for brain-wide analysis and interpretation of connectivity mapping data.

  10. Performance Study of the CMS Barrel Resistive Plate Chambers with Cosmic Rays

    CERN Document Server

    Chatrchyan, S; Sirunyan, A M; Adam, W; Arnold, B; Bergauer, H; Bergauer, T; Dragicevic, M; Eichberger, M; Erö, J; Friedl, M; Frühwirth, R; Ghete, V M; Hammer, J; Hänsel, S; Hoch, M; Hörmann, N; Hrubec, J; Jeitler, M; Kasieczka, G; Kastner, K; Krammer, M; Liko, D; Magrans de Abril, I; Mikulec, I; Mittermayr, F; Neuherz, B; Oberegger, M; Padrta, M; Pernicka, M; Rohringer, H; Schmid, S; Schöfbeck, R; Schreiner, T; Stark, R; Steininger, H; Strauss, J; Taurok, A; Teischinger, F; Themel, T; Uhl, D; Wagner, P; Waltenberger, W; Walzel, G; Widl, E; Wulz, C E; Chekhovsky, V; Dvornikov, O; Emeliantchik, I; Litomin, A; Makarenko, V; Marfin, I; Mossolov, V; Shumeiko, N; Solin, A; Stefanovitch, R; Suarez Gonzalez, J; Tikhonov, A; Fedorov, A; Karneyeu, A; Korzhik, M; Panov, V; Zuyeuski, R; Kuchinsky, P; Beaumont, W; Benucci, L; Cardaci, M; De Wolf, E A; Delmeire, E; Druzhkin, D; Hashemi, M; Janssen, X; Maes, T; Mucibello, L; Ochesanu, S; Rougny, R; Selvaggi, M; Van Haevermaet, H; Van Mechelen, P; Van Remortel, N; Adler, V; Beauceron, S; Blyweert, S; D'Hondt, J; De Weirdt, S; Devroede, O; Heyninck, J; Kalogeropoulos, A; Maes, J; Maes, M; Mozer, M U; Tavernier, S; Van Doninck, W; Van Mulders, P; Villella, I; Bouhali, O; Chabert, E C; Charaf, O; Clerbaux, B; De Lentdecker, G; Dero, V; Elgammal, S; Gay, A P R; Hammad, G H; Marage, P E; Rugovac, S; Vander Velde, C; Vanlaer, P; Wickens, J; Grunewald, M; Klein, B; Marinov, A; Ryckbosch, D; Thyssen, F; Tytgat, M; Vanelderen, L; Verwilligen, P; Basegmez, S; Bruno, G; Caudron, J; Delaere, C; Demin, P; Favart, D; Giammanco, A; Grégoire, G; Lemaitre, V; Militaru, O; Ovyn, S; Piotrzkowski, K; Quertenmont, L; Schul, N; Beliy, N; Daubie, E; Alves, G A; Pol, M E; Souza, M H G; Carvalho, W; De Jesus Damiao, D; De Oliveira Martins, C; Fonseca De Souza, S; Mundim, L; Oguri, V; Santoro, A; Silva Do Amaral, S M; Sznajder, A; Fernandez Perez Tomei, T R; Ferreira Dias, M A; Gregores, E M; Novaes, S F; Abadjiev, K; Anguelov, T; Damgov, J; Darmenov, N; 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Avery, P; Barashko, V; Bourilkov, D; Chen, M; Di Giovanni, G P; Dobur, D; Drozdetskiy, A; Field, R D; Fu, Y; Furic, I K; Gartner, J; Holmes, D; Kim, B; Klimenko, S; Konigsberg, J; Korytov, A; Kotov, K; Kropivnitskaya, A; Kypreos, T; Madorsky, A; Matchev, K; Mitselmakher, G; Pakhotin, Y; Piedra Gomez, J; Prescott, C; Rapsevicius, V; Remington, R; Schmitt, M; Scurlock, B; Wang, D; Yelton, J; Ceron, C; Gaultney, V; Kramer, L; Lebolo, L M; Linn, S; Markowitz, P; Martinez, G; Rodriguez, J L; Adams, T; Askew, A; Baer, H; Bertoldi, M; Chen, J; Dharmaratna, W G D; Gleyzer, S V; Haas, J; Hagopian, S; Hagopian, V; Jenkins, M; Johnson, K F; Prettner, E; Prosper, H; Sekmen, S; Baarmand, M M; Guragain, S; Hohlmann, M; Kalakhety, H; Mermerkaya, H; Ralich, R; Vodopiyanov, I; Abelev, B; Adams, M R; Anghel, I M; Apanasevich, L; Bazterra, V E; Betts, R R; Callner, J; Castro, M A; Cavanaugh, R; Dragoiu, C; Garcia-Solis, E J; Gerber, C E; Hofman, D J; Khalatian, S; Mironov, C; Shabalina, E; Smoron, A; Varelas, N; Akgun, U; Albayrak, E A; Ayan, A S; Bilki, B; Briggs, R; Cankocak, K; Chung, K; Clarida, W; Debbins, P; Duru, F; Ingram, F D; Lae, C K; McCliment, E; Merlo, J P; Mestvirishvili, A; Miller, M J; Moeller, A; Nachtman, J; Newsom, C R; Norbeck, E; Olson, J; Onel, Y; Ozok, F; Parsons, J; Schmidt, I; Sen, S; Wetzel, J; Yetkin, T; Yi, K; Barnett, B A; Blumenfeld, B; Bonato, A; Chien, C Y; Fehling, D; Giurgiu, G; Gritsan, A V; Guo, Z J; Maksimovic, P; Rappoccio, S; Swartz, M; Tran, N V; Zhang, Y; Baringer, P; Bean, A; Grachov, O; Murray, M; Radicci, V; Sanders, S; Wood, J S; Zhukova, V; Bandurin, D; Bolton, T; Kaadze, K; Liu, A; Maravin, Y; Onoprienko, D; Svintradze, I; Wan, Z; Gronberg, J; Hollar, J; Lange, D; Wright, D; Baden, D; Bard, R; Boutemeur, M; Eno, S C; Ferencek, D; Hadley, N J; Kellogg, R G; Kirn, M; Kunori, S; Rossato, K; Rumerio, P; Santanastasio, F; Skuja, A; Temple, J; Tonjes, M B; Tonwar, S C; Toole, T; Twedt, E; Alver, B; Bauer, G; Bendavid, J; Busza, W; Butz, E; Cali, I A; Chan, M; D'Enterria, D; Everaerts, P; Gomez Ceballos, G; Hahn, K A; Harris, P; Jaditz, S; Kim, Y; Klute, M; Lee, Y J; Li, W; Loizides, C; Ma, T; Miller, M; Nahn, S; Paus, C; Roland, C; Roland, G; Rudolph, M; Stephans, G; Sumorok, K; Sung, K; Vaurynovich, S; Wenger, E A; Wyslouch, B; Xie, S; Yilmaz, Y; Yoon, A S; Bailleux, D; Cooper, S I; Cushman, P; Dahmes, B; De Benedetti, A; Dolgopolov, A; Dudero, P R; Egeland, R; Franzoni, G; Haupt, J; Inyakin, A; Klapoetke, K; Kubota, Y; Mans, J; Mirman, N; Petyt, D; Rekovic, V; Rusack, R; Schroeder, M; Singovsky, A; Zhang, J; Cremaldi, L M; Godang, R; Kroeger, R; Perera, L; Rahmat, R; Sanders, D A; Sonnek, P; Summers, D; Bloom, K; Bockelman, B; Bose, S; Butt, J; Claes, D R; Dominguez, A; Eads, M; Keller, J; Kelly, T; Kravchenko, I; Lazo-Flores, J; Lundstedt, C; Malbouisson, H; Malik, S; Snow, G R; Baur, U; Iashvili, I; Kharchilava, A; Kumar, A; Smith, K; Strang, M; Alverson, G; Barberis, E; Boeriu, O; Eulisse, G; Govi, G; McCauley, T; Musienko, Y; Muzaffar, S; 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Neumeister, N; Sedov, A; Shipsey, I; Yoo, H D; Zheng, Y; Jindal, P; Parashar, N; Cuplov, V; Ecklund, K M; Geurts, F J M; Liu, J H; Maronde, D; Matveev, M; Padley, B P; Redjimi, R; Roberts, J; Sabbatini, L; Tumanov, A; Betchart, B; Bodek, A; Budd, H; Chung, Y S; de Barbaro, P; Demina, R; Flacher, H; Gotra, Y; Harel, A; Korjenevski, S; Miner, D C; Orbaker, D; Petrillo, G; Vishnevskiy, D; Zielinski, M; Bhatti, A; Demortier, L; Goulianos, K; Hatakeyama, K; Lungu, G; Mesropian, C; Yan, M; Atramentov, O; Bartz, E; Gershtein, Y; Halkiadakis, E; Hits, D; Lath, A; Rose, K; Schnetzer, S; Somalwar, S; Stone, R; Thomas, S; Watts, T L; Cerizza, G; Hollingsworth, M; Spanier, S; Yang, Z C; York, A; Asaadi, J; Aurisano, A; Eusebi, R; Golyash, A; Gurrola, A; Kamon, T; Nguyen, C N; Pivarski, J; Safonov, A; Sengupta, S; Toback, D; Weinberger, M; Akchurin, N; Berntzon, L; Gumus, K; Jeong, C; Kim, H; Lee, S W; Popescu, S; Roh, Y; Sill, A; Volobouev, I; Washington, E; Wigmans, R; Yazgan, E; Engh, D; Florez, C; Johns, W; Pathak, S; Sheldon, P; Andelin, D; Arenton, M W; Balazs, M; Boutle, S; Buehler, M; Conetti, S; Cox, B; Hirosky, R; Ledovskoy, A; Neu, C; Phillips II, D; Ronquest, M; Yohay, R; Gollapinni, S; Gunthoti, K; Harr, R; Karchin, P E; Mattson, M; Sakharov, A; Anderson, M; Bachtis, M; Bellinger, J N; Carlsmith, D; Crotty, I; Dasu, S; Dutta, S; Efron, J; Feyzi, F; Flood, K; Gray, L; Grogg, K S; Grothe, M; Hall-Wilton, R; Jaworski, M; Klabbers, P; Klukas, J; Lanaro, A; Lazaridis, C; Leonard, J; Loveless, R; Magrans de Abril, M; Mohapatra, A; Ott, G; Polese, G; Reeder, D; Savin, A; Smith, W H; Sourkov, A; Swanson, J; Weinberg, M; Wenman, D; Wensveen, M; White, A

    2010-01-01

    In October and November 2008, the CMS collaboration conducted a programme of cosmic ray data taking, which has recorded about 270 million events. The Resistive Plate Chamber system, which is part of the CMS muon detection system, was successfully operated in the full barrel. More than 98% of the channels were operational during the exercise with typical detection efficiency of 90%. In this paper, the performance of the detector during these dedicated runs is reported.

  11. Right and left support feet of the Central Barrel Yoke of the CMS Detector

    CERN Multimedia

    Franz Leher, DWE

    2000-01-01

    Fully loaded the Central Barrel will weigh 3000 tonnes. Those feet have tosupport this weight. Therefore they are made of 120 mm thick steel plates.To guarantee a maximum coverage for the muon detctor they will house a muon detector just benaeth the top plate. Weight of 1 foot is 35 tonnes.Its height is 3.5 m and it is 2.5 m large

  12. Test of the wire ageing induced by radiation for the CMS barrel muon chambers

    CERN Document Server

    Conti, E

    2001-01-01

    We have carried out laboratory tests to measure the ageing of a wire tube due to pollutants outgassed by various materials. The tested materials are those used in the barrel muon drift tubes of the CMS experiment at LHC. An X-ray gun irradiated the test tube to accelerate the ageing process. No ageing effect has been measured for a period equivalent to 10 years of operation at LHC. (15 refs).

  13. Double-barreled wet colostomy: a safe and simple method after pelvic exenteration.

    Science.gov (United States)

    Osorio Gullón, A; de Oca, J; Lopéz Costea, M A; Virgili, J; Ramos, E; del Rio, C; Martí Ragué, J

    1997-01-01

    The clinical and functional outcome of ureteric division to the distal segment of a loop colostomy: the double-barrelled wet colostomy have been analysed. 13 patients (8 female and 5 male, age 37 to 72 years) underwent pelvic exenteration with double-barrelled wet colostomy. The primary tumour included endometrial (n = 6), rectal (n = 1), anal (n = 1), cervical (n = 2), prostatic (n = 1) and bladder (n = 2). Indications for pelvic exenteration were locally advanced disease, recurrence and severe radiation or surgical damage. Six patients had pre-existing colostomy, and three had a Bricker ureteroileal diversion. The double-barrelled-wet colostomy technique consisted in anastomosing both ureters to a colon segment 25 cm distal to the loop colostomy. There was no operative mortality. Complications included one urinary leak which closed with conservative management and one case of recurrent episodes of pyelonephritis which finally required nephrectomy. Intravenous urography in the remaining patients showed good flow through the ureters to the conduit with no reflux. Postoperative plasma electrolytes, urea and creatinine were normal from day seven onwards. Urodynamic studies in four patients showed efficient contraction of the colon conduit with pressure levels similar to those in the colon proximal to the colostomy. In five cases biopsies of the conduit were taken at 3 and 16 months; no dysplasias were found. Four patients died due to disease progression. The overall mean survival was 41.2 months. The remainder are currently disease-free, maximum followup period being 19 months. Double-barrelled wet colostomy is a safe and simple technique with low morbidity. The patient needs to carry only one stoma and functional results are good.

  14. Barrel organ of plate tectonics - a new tool for outreach and education

    Science.gov (United States)

    Broz, Petr; Machek, Matěj; Šorm, Zdar

    2016-04-01

    Plate tectonics is the major geological concept to explain dynamics and structure of Earth's outer shell, the lithosphere. In the plate tectonic theory processes in the Earth lithosphere and its dynamics is driven by the relative motion and interaction of lithospheric plates. Geologically most active regions on Earth often correlate with the lithospheric plate boundaries. Thus for explaining the earth surface evolution, mountain building, volcanism and earthquake origin it is important to understand processes at the plate boundaries. However these processes associated with plate tectonics usually require significant period of time to take effects, therefore, their entire cycles cannot be directly observed in the nature by humans. This makes a challenge for scientists studying these processes, but also for teachers and popularizers trying to explain them to students and to the general public. Therefore, to overcome this problem, we developed a mechanical model of plate tectonics enabling demonstration of most important processes associated with plate tectonics in real time. The mechanical model is a wooden box, more specifically a special type of barrel organ, with hand painted backdrops in the front side. These backdrops are divided into several components representing geodynamic processes associated with plate tectonics, specifically convective currents occurring in the mantle, sea-floor spreading, a subduction of the oceanic crust under the continental crust, partial melting and volcanism associated with subduction, a formation of magmatic stripes, an ascent of mantle plume throughout the mantle, a volcanic activity associated with hot spots, and a formation and degradation of volcanic islands on moving lithospheric plate. All components are set in motion by a handle controlled by a human operator, and the scene is illuminated with colored lights controlled automatically by an electric device embedded in the box. Operation of the model may be seen on www

  15. Demographics of increasing populations of the giant barrel sponge Xestospongia muta in the Florida Keys.

    Science.gov (United States)

    McMurray, Steven E; Henkel, Timothy P; Pawlik, Joseph R

    2010-02-01

    The structure of Caribbean coral reef communities has been altered by numerous anthropogenic and natural stressors. Demographic studies of key functional groups have furthered efforts to describe and understand these changes. Little is known, however, about the demographics of sponges on coral reefs, despite their abundance and the important functions they perform (e.g., increased habitat complexity, water filtration). We have monitored permanent plots on reefs off Key Largo, Florida, USA, to study the demography of a particularly important species, the giant barrel sponge, Xestospongia muta. From 2000 to 2006, population densities of X. muta significantly increased at sites on Conch Reef by a mean of 46% (range = 16-108%) and on Pickles Reef by a mean of 33%. In 2006, densities of X. muta on Conch Reef ranged from 0.134 to 0.277 sponges/m2, and mean sponge volume was 1488 cm3/m2, with the largest size class of sponges constituting 75% of the total volume. Increased population density resulted from a significant increase in the number of sponges in the smallest size class. Recruit survival did not significantly change through time; however, a significant interaction between season and year on recruitment suggests that large recruitment pulses are driving population increases. Mean yearly recruitment rates ranged from 0.011 to 0.025 recruits x m(-2) x yr(-1), with pulses as high as 0.036 recruits/m2. To explore the demographic processes behind the population increase and determine future population growth of X. muta under present reef conditions, a stage-based matrix modeling approach was used. Variable recruitment pulses and mortality events were hypothesized to be large determinants of the demographic patterns observed for X. muta. Elasticity and life table response analysis revealed that survival of individuals in the largest size class has the greatest effect on population growth. Projections indicate that populations of X. muta will continue to increase under

  16. A distinct population of Saccharomyces cerevisiae in New Zealand: evidence for local dispersal by insects and human-aided global dispersal in oak barrels.

    Science.gov (United States)

    Goddard, Matthew R; Anfang, Nicole; Tang, Rongying; Gardner, Richard C; Jun, Casey

    2010-01-01

    Humans have used S. cerevisiae to make alcoholic beverages for at least 5000 years and now this super-model research organism is central to advances in our biological understanding. Current models for S. cerevisiae suggest that its population comprises distinct domesticated and natural groups as well as mosaic strains, but we generally know little of the forces which shape its population structure. In order to test the roles that ecology and geography play in shaping the S. cerevisiae species we examined nine variable microsatellite loci in 172 strains of S. cerevisiae isolated from two spontaneous grape juice ferments, soil, flowers, apiaries and bark in New Zealand. Bayesian analysis shows that the S. cerevisiae in NZ comprise a subdivided but interbreeding population that out-crosses approximately 20% of the time. Some strains contributing to spontaneous ferments cluster with NZ soil/bark isolates, but others cluster with isolates from French oak barrels. It seems some strains have been globally dispersed by humans in oak barrels while some are locally vectored by insects. These data suggest geography is more important than ecology in shaping S. cerevisiae's population structure.

  17. Upgrade of the CMS muon trigger system in the barrel region

    CERN Document Server

    Rabady, Dinyar; Carlin, Roberto; Codispoti, Giuseppe; Dallavalle, Marco; Erö, Janos; Flouris, Giannis; Foudas, Costas; Fulcher, Jonathan; Guiducci, Luigi; Loukas, Nikitas; Mallios, Stavros; Manthos, Nikos; Papadopoulos, Ioannis; Paradas, Evangelos; Reis, Thomas; Sakulin, Hannes; Sphicas, Paris; Triossi, Andrea; Venturi, Andrea; Wulz, Claudia-Elisabeth

    2016-01-01

    To maintain the excellent performance of the LHC during its Run-1 also in Run-2, the Level-1 Trigger of the Compact Muon Solenoid experiment underwent a significant upgrade. One part of this upgrade was the re-organisation of the muon trigger path from a subsystem-centric view in which hits in the drift tubes, the cathode strip chambers, and the resistive plate chambers were treated separately in dedicated track-finding systems, to one in which complementary detector systems for a given region (barrel, overlap, and endcap) are merged already at the track-finding level. This also required the development of a new system to sort as well as cancel-out the muon tracks found by each system. An overview will be given of the new track-finder system for the barrel region, the Barrel Muon Track Finder (BMTF) as well as the cancel-out and sorting layer, the upgraded Global Muon Trigger (µGMT). While the BMTF improves on the proven and well-tested algorithms used in the Drift Tube Track Finder during Run-1, the µGMT i...

  18. Resource Review Board Celebrates the Magnet and Liquid Argon Barrel Tests in Hall 180

    CERN Document Server

    Jenni, P.

    2004-01-01

    Address by the Director-General, R. Aymar, in front of the barrel cryostat. On 25th October 2004 many RRB delegates and guests, ATLAS National Contact Physicists, and colleagues from far and from CERN working on the Liquid Argon calorimeter and the magnet system were gathering in Hall 180 to celebrate the major milestones reached during the past months in this hall: the successful cold tests of the first barrel toroid coil, of the solenoid, and of the barrel Liquid Argon calorimeter. About 250 people spent a relaxing evening after the speeches by the Director-General R. Aymar and by the spokesperson who gave the following address: 'It is a great pleasure for me to welcome you all here in Hall 180 in the name of the ATLAS Collaboration! With a few words I would like to recall why we are actually here today to share, what I hope, is a relaxed and joyful moment. To concentrate it all in one sentence I could say: To thank cordially all the main actors for the enormous work accomplished here over many years,...

  19. Dead zone analysis of ECAL barrel modules under static and dynamic load

    Science.gov (United States)

    Pierre-Emile, T.; Anduze, M.

    2018-03-01

    In the context of ILD project, impact studies of environmental loads on the Electromagnetic CALorimeter (ECAL) have been initiated. The ECAL part considered is the barrel and it consists of several independent modules which are mounted on the Hadronic CALorimeter barrel (HCAL) itself mounted on the cryostat coil and the yoke. The estimate of the gap required between each ECAL modules is fundamental to define the assembly step and avoid mechanical contacts over the barrel lifetime. In the meantime, it has to be done in consideration to the dead spaces reduction and detector hermiticity optimization. Several Finite Element Analysis (FEA) with static and dynamic loads have been performed in order to define correctly the minimum values for those gaps. Due to the implantation site of the whole project in Japan, seismic analysis were carried out in addition to the static ones. This article shows results of these analysis done with the Finite Element Method (FEM) in ANSYS. First results show the impact of HCAL design on the ECAL modules motion in static load. The second study dedicated to seismic approach on a larger model (including yoke and cryostat) gives additional results on earthquake consequences.

  20. Performances of the ATLAS Level-1 Muon barrel trigger during the Run-II data taking

    CERN Document Server

    Sessa, Marco; The ATLAS collaboration

    2017-01-01

    The Level-1 Muon Barrel Trigger is one of the main elements of the event selection of the ATLAS experiment at the Large Hadron Collider. It exploits the Resistive Plate Chambers (RPC) detectors to generate the trigger signal. The RPCs are placed in the barrel region of the ATLAS experiment: they are arranged in three concentric double layers and operate in a strong magnetic toroidal field. RPC detectors cover the pseudo-rapidity range $|\\eta|<1.05$ for a total surface of more than $4000\\ m^2$ and about 3600 gas volumes. The Level-1 Muon Trigger in the barrel region allows to select muon candidates with respect to their transverse momentum and associates them with the correct bunch-crossing number. The trigger system is able to take a decision within a latency of about 2 $\\mu s$. The detailed measurement of the RPC detector efficiencies and of the trigger performance during the ATLAS Run-II data taking is here presented.

  1. Supra-barrel Distribution of Directional Tuning for Global Motion in the Mouse Somatosensory Cortex.

    Science.gov (United States)

    Vilarchao, María Eugenia; Estebanez, Luc; Shulz, Daniel E; Férézou, Isabelle

    2018-03-27

    Rodents explore their environment with an array of whiskers, inducing complex patterns of whisker deflections. Cortical neuronal networks can extract global properties of tactile scenes. In the primary somatosensory cortex, the information relative to the global direction of a spatiotemporal sequence of whisker deflections can be extracted at the single neuron level. To further understand how the cortical network integrates multi-whisker inputs, we imaged and recorded the mouse barrel cortex activity evoked by sequences of multi-whisker deflections generating global motions in different directions. A majority of barrel-related cortical columns show a direction preference for global motions with an overall preference for caudo-ventral directions. Responses to global motions being highly sublinear, the identity of the first deflected whiskers is highly salient but does not seem to determine the global direction preference. Our results further demonstrate that the global direction preference is spatially organized throughout the barrel cortex at a supra-columnar scale. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

  2. Forming H-shaped and barrel-shaped nebulae with interacting jets

    Science.gov (United States)

    Akashi, Muhammad; Bear, Ealeal; Soker, Noam

    2018-04-01

    We conduct three-dimensional hydrodynamical simulations of two opposite jets with large opening angles launched from a binary stellar system into a previously ejected shell and show that the interaction can form barrel-like and H-like shapes in the descendant nebula. Such features are observed in planetary nebulae (PNe) and supernova remnants. Under our assumption, the dense shell is formed by a short instability phase of the giant star as it interacts with a stellar companion, and the jets are then launched by the companion as it accretes mass through an accretion disc from the giant star. We find that the H-shaped and barrel-shaped morphological features that the jets form evolve with time, and that there are complicated flow patterns, such as vortices, instabilities, and caps moving ahead along the symmetry axis. We compare our numerical results with images of 12 PNe, and show that jet-shell interaction that we simulate can account for the barrel-like or H-like morphologies that are observed in these PNe.

  3. Design studies for the Phase II upgrade of the CMS Barrel Electromagnetic Calorimeter

    CERN Document Server

    Orimoto, Toyoko Jennifer

    2016-01-01

    The High Luminosity LHC (HL-LHC) will provide unprecedented instantaneous and integrated luminosity. The lead tungstate crystals forming the barrel part of the Electromagnetic Calorimeter (ECAL) of the Compact Muon Solenoid (CMS) will still perform well, even after the expected integrated luminosity of 3000fb-1 at the end of HL-LHC. The avalanche photodiodes (APDs) used to detect the scintillation light will also continue to be operational, although there will be some increase in noise due to radiation-induced dark currents. This will be mitigated by reducing the barrel operating temperature during HL-LHC running.The front-end electronics of the ECAL barrel will be replaced, in order to remove existing constraints on trigger rate and latency and to provide additional capability to fully exploit the higher luminosity delivered by the HL-LHC. New developments in high-speed optical links will allow single-crystal readout at 40 MHz to upgraded off-detector processors, allowing maximum flexibility and enhanced tri...

  4. Upgrade of the CMS muon trigger system in the barrel region

    CERN Document Server

    AUTHOR|(CDS)2080489; Flouris, Gianis; Fulcher, Jonathan; Loukas, Nikitas; Paradas, Evangelos; Reis,Thomas; Sakulin, Hannes; Wulz, Claudia-Elisabeth

    2016-01-01

    To maintain the excellent performance shown during the LHCs Run-1 the Level-1 Trigger of the Compact Muon Solenoid experiment underwent a significant upgrade. One part of this upgrade is the re-organization of the muon trigger path from a subsystem-centric view in which hits in the drift tubes (DT), the cathode strip chambers (CSC), and the resistive plate chambers (RPC) were treated separately in dedicated track-finding systems to one in which complementary detector systems for a given region (barrel, overlap, and endcap) are merged at the track-finding level. This fundamental restructuring of the muon trigger system required the development of a system to receive track candidates from the track-finding layer, remove potential duplicate tracks, and forward the best candidates to the global decision layer.An overview will be given of the new track-finder system for the barrel region, the Barrel Muon Track Finder (BMTF) as well as the cancel-out and sorting layer, the upgraded Global Muon Trigger ($\\mu$GMT). B...

  5. Fabrication of a high-integration multi-spectral imaging lens and its application

    Science.gov (United States)

    Jin, Jian; Di, Si; Chen, Xianshuai

    2017-10-01

    In this paper, a high-integration multi-spectral imaging lens was developed by micro-fabrication technology. By using multiple photo-etching and thermal reflow process, a microlens array and a multi-channels filter were integrated together without position mismatch. Besides, light block layer and isolation layer were brought in the structure to improve the imaging quality. Its fabrication process is described in detail and the optical property was tested by imaging experiments. The multi-spectral imaging lens has 9 optical channels, each channel capable of filtering and imaging independently. The imaging results indicate that the lens can capture pictures of visible bands and near-infrared band at the same time. Because of its high level of integration and image parallel capture capability, the novel lens is suitable to be applied in extracting conceal information and biomedical imaging.

  6. 3D field-shaping lens using all-dielectric gradient refractive index materials.

    Science.gov (United States)

    Ding, Tongyu; Yi, Jianjia; Li, Haoyu; Zhang, Hailin; Burokur, Shah Nawaz

    2017-04-10

    A novel three-dimensional (3D) optical lens structure for electromagnetic field shaping based on spatial light transformation method is proposed at microwave frequencies. The lens is capable of transforming cylindrical wavefronts into planar ones, and generating a directive emission. Such manipulation is simulated and analysed by solving Laplace's equation, and the deformation of the medium during the transformation is theoretically described in detail. The two-dimensional (2D) design method producing quasi-isotropic parameters is further extended to a potential 3D realization with all-dielectric gradient refractive index metamaterials. Numerical full-wave simulations are performed on both 2D and 3D models to verify the functionality and broadband characteristics of the calculated lens. Far-field radiation patterns and near-field distributions demonstrate a highly radiated directive beam when the lens is applied to a conical horn antenna.

  7. A new technique for insertion of barrel plate over dy-namic hip/compression lag screw: a case report

    Directory of Open Access Journals (Sweden)

    Naranje Sameer

    2012-08-01

    Full Text Available 【Abstract】Dynamic hip/compression screw (DHS/ DCS is one of the most commonly performed surgeries in orthopaedic practice. Sliding barrel plate over the DHS/DCS lag screw is one of the very crucial and at times uncomfor-table and time consuming steps of DHS/DCS surgery espe-cially when it comes to inexperienced surgeons and residents. Also in developing countries where not all stan-dard instrumentation is always available, this crucial step becomes more time consuming. Here we present a case re-port of 58-year-old male patient with intertrochanteric fracture, in which we used a new device for insertion of barrel plate over DHS/DCS lag screw and found that a small DHS/DCS lag screw extension (sliding jig of barrel plate can be very helpful to slide barrel plate over the DHS/DCS lag screw. Key words: Bone screws; Intertrochanteric fracture; Femoral fracture

  8. Shifts in developmental timing, and not increased levels of experience-dependent neuronal activity, promote barrel expansion in the primary somatosensory cortex of rats enucleated at birth.

    Directory of Open Access Journals (Sweden)

    Ingrid Fetter-Pruneda

    Full Text Available Birth-enucleated rodents display enlarged representations of whiskers (i.e., barrels of the posteromedial subfield in the primary somatosensory cortex. Although the historical view maintains that barrel expansion is due to incremental increases in neuronal activity along the trigeminal pathway during postnatal development, recent evidence obtained in experimental models of intramodal plasticity challenges this view. Here, we re-evaluate the role of experience-dependent neuronal activity on barrel expansion in birth-enucleated rats by combining various anatomical methods and sensory deprivation paradigms. We show that barrels in birth-enucleated rats were already enlarged by the end of the first week of life and had levels of metabolic activity comparable to those in control rats at different ages. Dewhiskering after the postnatal period of barrel formation did not prevent barrel expansion in adult, birth-enucleated rats. Further, dark rearing and enucleation after barrel formation did not lead to expanded barrels in adult brains. Because incremental increases of somatosensory experience did not promote barrel expansion in birth-enucleated rats, we explored whether shifts of the developmental timing could better explain barrel expansion during the first week of life. Accordingly, birth-enucleated rats show earlier formation of barrels, accelerated growth of somatosensory thalamocortical afferents, and an earlier H4 deacetylation. Interestingly, when H4 deacetylation was prevented with a histone deacetylases inhibitor (valproic acid, barrel specification timing returned to normal and barrel expansion did not occur. Thus, we provide evidence supporting that shifts in developmental timing modulated through epigenetic mechanisms, and not increased levels of experience dependent neuronal activity, promote barrel expansion in the primary somatosensory cortex of rats enucleated at birth.

  9. An analytical method for predicting the geometrical and optical properties of the human lens under accommodation

    Science.gov (United States)

    Sheil, Conor J.; Bahrami, Mehdi; Goncharov, Alexander V.

    2014-01-01

    We present an analytical method to describe the accommodative changes in the human crystalline lens. The method is based on the geometry-invariant lens model, in which the gradient-index (GRIN) iso-indicial contours are coupled to the external shape. This feature ensures that any given number of iso-indicial contours does not change with accommodation, which preserves the optical integrity of the GRIN structure. The coupling also enables us to define the GRIN structure if the radii and asphericities of the external lens surfaces are known. As an example, the accommodative changes in lenticular radii and central thickness were taken from the literature, while the asphericities of the external surfaces were derived analytically by adhering to the basic physical conditions of constant lens volume and its axial position. The resulting changes in lens geometry are consistent with experimental data, and the optical properties are in line with expected values for optical power and spherical aberration. The aim of the paper is to provide an anatomically and optically accurate lens model that is valid for 3 mm pupils and can be used as a new tool for better understanding of accommodation. PMID:24877022

  10. The Effects of CO2 Injection and Barrel Temperatures on the Physiochemical and Antioxidant Properties of Extruded Cereals

    OpenAIRE

    Thin, Thazin; Myat, Lin; Ryu, Gi-Hyung

    2016-01-01

    The effects of CO2 injection and barrel temperatures on the physiochemical and antioxidant properties of extruded cereals (sorghum, barley, oats, and millet) were studied. Extrusion was carried out using a twin-screw extruder at different barrel temperatures (80, 110, and 140?C), CO2 injection (0 and 500 mL/min), screw speed of 200 rpm, and moisture content of 25%. Extrusion significantly increased the total flavonoid content (TFC) of extruded oats, and ?-glucan and protein digestibility (PD)...

  11. Cuba Through A New Lens

    Directory of Open Access Journals (Sweden)

    Jean Stubbs

    2008-12-01

    Full Text Available [First paragraph] The Origins of the Cuban Revolution Reconsidered. Samuel Farber. Chapel Hill: University of North Carolina Press, 2006. x + 212 pp. (Paper US$ 19.95 Cuba: A New History. Ric hard Gott . New Haven: Yale University Press, 2005. xii + 384 pp. (Paper US$ 17.00 Havana: The Making of Cuban Culture. Antoni Kapcia. Oxford: Berg Publishers, 2005. xx + 236 pp. (Paper US$ 24.95 Richard Gott, Antoni Kapcia, and Samuel Farber each approach Cuba through a new lens. Gott does so by providing a broad-sweep history of Cuba, which is epic in scope, attaches importance to social as much as political and economic history, and blends scholarship with flair. Kapcia homes in on Havana as the locus for Cuban culture, whereby cultural history becomes the trope for exploring not only the city but also Cuban national identity. Farber revisits his own and others’ interpretations of the origins of the Cuban Revolution.

  12. Radiation studies in Lens culinaris

    International Nuclear Information System (INIS)

    Sinha, S.S.N.

    1977-01-01

    Estimation of chromosomal aberrations in flowers of Lens culinaris according to their sequence of development in the plants at 4, 8 and 12 Kr in the M 1 generation, showed that the later formed flowers had smaller percentages of cells with aberrations than those developed earlier. It is suggested that this may be the result of competition between more damaged and less damaged cells during the development of the shoot. There is consequently a decrease of sterility in successive flowers. The numbers of karyotypes taking part in the formation of lower and uppermost flowers were estimated cytologically at 4, 8 and 12 Kr. It was found that more karyotypes were involved in the formation of the lower flowers than in the upper ones. It appeared that at lower doses larger numbers of karyotypes were taking part in the formation of the chimaera than at higher doses. (auth.)

  13. Microbial contamination of contact lens storage cases and domestic tap water of contact lens wearers.

    Science.gov (United States)

    Üstüntürk, Miray; Zeybek, Zuhal

    2012-11-01

    Contact lenses have been widely used as an alternative to spectacles both in developed and developing countries. However, under certain circumstances, adverse responses can occur during contact lens wear and several microorganisms--including bacteria, fungi, and free living amoebae--can cause several eye infections in wearers. Extended wear of contact lenses is the major risk factor of eye infections such as microbial keratitis, besides contaminated contact lens storage case, contaminated lens care solutions, and inaccurate contact lens handling. In this study, we collected contact lens storage case and domestic tap water samples from 50 asymptomatic contact lens wearers. We determined that total aerobic mesophilic bacteria were isolated in 45 (90 %), Gram negative rod bacteria were isolated in 20 (40 %), Pseudomonas spp. were isolated in 2 (4 %) and fungi were isolated in 18 (36 %) out of 50 contact lens storage cases. Free living amoebae were not detected in investigated contact lens storage cases. At the same time, out of 50, total aerobic mesophilic bacteria were isolated in 34 (68 %), fungi were isolated in 15 (30 %) and free living amoebae were isolated in 15 (30 %) domestic tap water samples. No Gram-negative rod bacteria and Pseudomonas spp. were detected in investigated water samples. Two contact lens case samples and two tap water samples were excluded from the analysis for Pseudomonas spp. for technical reasons. According to our findings, inadequate contact lens maintenance during lens wear may result in the contamination of contact lens storage cases. This situation can lead to severe eye infections in contact lens wearers over time.

  14. Contact lens compliance among a group of young, university-based lens users in South India.

    Science.gov (United States)

    Noushad, Babu; Saoji, Yeshwant; Bhakat, Premjit; Thomas, Jyothi

    2012-01-01

    To investigate the rate of compliance with the soft contact lens care and maintenance procedures with a focus on contact lens wearing habits, cleaning and disinfecting procedures, and maintenance of lens care accessories in a group of young, university-based contact lens wearers Two hundred and sixteen young soft contact lens wearers with an age range of 18-22 years were selected conveniently from the student population of Manipal University, Manipal, India. After receiving informed consent from the participants, their level of compliance with contact lenses was assessed using a questionnaire. The mean (±SD) age of the participants was 21.86±2.35 years. Out of 216 subjects, only 34% of the lens users were identified to be compliant with the least level of compliance observed in the maintenance of lens care accessories. Conventional users showed significantly (p=0.001) better level of compliance compared to disposable wearers and so did the users who acquired their lenses from clinicians (p=0.001) compared to over-the-counter lens receipt. The gender (p=0.496) and years of experience in contact lens use (p=0.142) did not show any statistically significant difference in the level of compliance. This study demonstrated that non-compliance with lens care procedures among a group of young, university-based soft contact lens wearers is common. The results indicated that all subjects had some degree of non-compliance and the least level of compliance observed in the care of lens accessories.

  15. Tear film physiology and contact lens wear. II. Contact lens-tear film interaction.

    Science.gov (United States)

    Holly, F J

    1981-04-01

    The successful fitting of contact lenses requires the practitioner to take into account many properties of the specific lens type used but the practitioner must also understand patient factors including tear properties, use of appropriate solutions, procedures for lens cleaning, and efficiency of blinking. Selection of appropriate patients, selection of lens type, proper fitting, good maintenance, and training and monitoring of patients increase the probability of achieving success.

  16. Placement of a crystalline lens and intraocular lens: Retinal image quality.

    Science.gov (United States)

    Siedlecki, Damian; Nowak, Jerzy; Zajac, Marek

    2006-01-01

    The influence of changes of both crystalline lens and intraocular lens (IOL) misalignment on the retinal image quality was investigated. The optical model of the eye used in investigations was the Liou-Brennan model, which is commonly considered as one of the most anatomically accurate. The original crystalline lens from this model was replaced with an IOL, made of rigid polymethylmethacrylate, in a way that recommend obligatory procedures. The modifications that were made both for crystalline lens and IOL were the longitudinal, the transversal, and the angular displacement.

  17. Development of Fresnel lens for improvement of rear visibility; Shikai kojo Fresnel lens no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Iwamoto, K.; Sanada, C.; Tsukino, M. [Nissan Motor Co. Ltd., Tokyo (Japan)

    1997-10-01

    Fresnel lenses have been widely used to increase the visual field around vehicles for drivers. However, internal reflection in these lenses has been an obstacle in producing dear images. This internal glow is generated by incident light from an unexpected direction reflecting on the non-lens surface or radiating from the non-lens surface of the Fresnel lens. The cause of internal glow has been made dear combining louver film with the lens. The newly developed technology removes obstacles in producing dear images by reducing internal glow. 7 figs.

  18. Process qualification and testing of LENS deposited AY1E0125 D-bottle brackets.

    Energy Technology Data Exchange (ETDEWEB)

    Atwood, Clinton J.; Smugeresky, John E. (Sandia National Labs, Livermore,CA); Jew, Michael (Sandia National Labs, Livermore,CA); Gill, David Dennis; Scheffel, Simon (Sandia National Labs, Livermore,CA)

    2006-11-01

    The LENS Qualification team had the goal of performing a process qualification for the Laser Engineered Net Shaping{trademark}(LENS{reg_sign}) process. Process Qualification requires that a part be selected for process demonstration. The AY1E0125 D-Bottle Bracket from the W80-3 was selected for this work. The repeatability of the LENS process was baselined to determine process parameters. Six D-Bottle brackets were deposited using LENS, machined to final dimensions, and tested in comparison to conventionally processed brackets. The tests, taken from ES1E0003, included a mass analysis and structural dynamic testing including free-free and assembly-level modal tests, and Haversine shock tests. The LENS brackets performed with very similar characteristics to the conventionally processed brackets. Based on the results of the testing, it was concluded that the performance of the brackets made them eligible for parallel path testing in subsystem level tests. The testing results and process rigor qualified the LENS process as detailed in EER200638525A.

  19. Biologically inspired LED lens from cuticular nanostructures of firefly lantern

    Science.gov (United States)

    Kim, Jae-Jun; Lee, Youngseop; Kim, Ha Gon; Choi, Ki-Ju; Kweon, Hee-Seok; Park, Seongchong; Jeong, Ki-Hun

    2012-01-01

    Cuticular nanostructures found in insects effectively manage light for light polarization, structural color, or optical index matching within an ultrathin natural scale. These nanostructures are mainly dedicated to manage incoming light and recently inspired many imaging and display applications. A bioluminescent organ, such as a firefly lantern, helps to out-couple light from the body in a highly efficient fashion for delivering strong optical signals in sexual communication. However, the cuticular nanostructures, except the light-producing reactions, have not been well investigated for physical principles and engineering biomimetics. Here we report a unique observation of high-transmission nanostructures on a firefly lantern and its biological inspiration for highly efficient LED illumination. Both numerical and experimental results clearly reveal high transmission through the nanostructures inspired from the lantern cuticle. The nanostructures on an LED lens surface were fabricated by using a large-area nanotemplating and reconfigurable nanomolding with heat-induced shear thinning. The biologically inspired LED lens, distinct from a smooth surface lens, substantially increases light transmission over visible ranges, comparable to conventional antireflection coating. This biological inspiration can offer new opportunities for increasing the light extraction efficiency of high-power LED packages. PMID:23112185

  20. Night Vision Goggles Objectives Lens Focusing Methodology

    National Research Council Canada - National Science Library

    Pinkus, Alan; Task, H. L

    2000-01-01

    ...: interpupillary distance, tilt, eye relief, height, eyepiece and objective lens focus. Currently, aircrew use a Hoffman 20/20 test unit to pre-focus their NVG objective lenses at optical infinity before boarding their aircraft...

  1. Comparison of lens oxidative damage induced by vitrectomy and/or hyperoxia in rabbits

    Directory of Open Access Journals (Sweden)

    Hong Yan

    2017-02-01

    Full Text Available AIM: To compare of lens oxidative damage induced by vitrectomy and/or hyperoxia in rabbit. METHODS: Sixteen New Zealand rabbits (2.4-2.5 kg were randomly divided into two groups (Group A, n=12; Group B, n=4. In Group A, the right eyes were treated with vitrectomy and systemic hyperoxia (oxygen concentration: 80%-85%, 1 ATA, 4h/d (Group A-right, and the left eyes were treated with hyperoxia without vitrectomy surgery (Group A-left. Four rabbits in group B (eight eyes were untreated as the controls. Lens transparency was monitored with a slit lamp and recorded before and after vitrectomy. After hyperoxic treatment for 6mo, the eyeballs were removed and the lens cortices (containing the capsules and nuclei were separated for further morphological and biochemical evaluation. RESULTS: Six months after treatments, there were no significant morphological changes in the lenses in any experimental group when observed with a slit lamp. However, the levels of water-soluble proteins and ascorbate, and the activities of catalase and Na+-K+-ATPase were significantly reduced, whereas the levels of malondialdehyde and transforming growth factor β2 (TGF-β2 were significantly elevated, in both the cortices and nuclei of eyes treated with vitrectomy and hyperoxia. The increase in protein-glutathione mixed disulfides and the reduction in water-soluble proteins were more obvious in the lens nuclei. The levels of ascorbate in the vitreous fluid were also reduced after vitrectomy, whereas TGF-β2 increased after vitrectomy and hyperoxia. Systemic hyperoxia exposure increased these effects. CONCLUSION: Removal of the intact vitreous gel with vitrectomy and exposing the lens to increased oxygen from the retina induce lens oxidation and aggregation. Thus, an intact vitreous gel structure may protect the lens from oxidative insult and maintain lens transparency.

  2. Contractual considerations in contact lens practice.

    Science.gov (United States)

    Classé, J G

    1986-03-01

    The use of forms in contact lens practice can save time, promote patient education, and reduce the opportunity for legal or economic disputes. The most commonly employed forms are those for contact lens fitting agreements, instructions for care and maintenance of lenses, prepaid service agreements, clinical investigations of investigatory lenses or solutions, and for extended wear patients. Sample forms are utilized for purposes of illustration.

  3. Evolution and the Calcite Eye Lens

    OpenAIRE

    Williams, Vernon L.

    2013-01-01

    Calcite is a uniaxial, birefringent crystal, which in its optically transparent form, has been used for animal eye lenses, the trilobite being one such animal. Because of the calcite birefringence there is a difficulty in using calcite as a lens. When the propagation direction of incoming light is not exactly on the c-axis, the mages blur. In this paper, calcite blurring is evaluated, and the non-blurring by a crystallin eye lens is compared to a calcite one.

  4. Acute lens-induced glaucomas: A review

    Directory of Open Access Journals (Sweden)

    Syed Shoeb Ahmad

    2017-02-01

    Full Text Available Lens-induced factors are important and common mechanisms causing acute elevation of intraocular pressure. While in most cases, the diagnosis and management are straight-forward, in others it is difficult and can lead to improper procedures, complications and poor visual outcomes. This review was done with the aim of studying the various types of lens-induced glaucomas, classifying them in an easy way to understand manner, their clinical features, current management and future possibilities.

  5. Environmental drivers of microbial community shifts in the giant barrel sponge, Xestospongia muta, over a shallow to mesophotic depth gradient.

    Science.gov (United States)

    Morrow, Kathleen M; Fiore, Cara L; Lesser, Michael P

    2016-06-01

    The giant barrel sponge, Xestospongia muta, is a high microbial abundance sponge found on Caribbean coral reefs along shallow to mesophotic depth gradients where multiple abiotic factors change with depth. Sponges were collected along a depth gradient at Little Cayman (LC) and Lee Stocking Island (LSI), and the microbiome of these samples was analysed using 16S rRNA amplicon sequencing. Statistically significant shifts in community structure and dissimilarity (∼ 40%) were detected from 10 to 90 m in LC sponges, but a similar shift was not identified in sponges from 10 to 60 m at LSI (only 17% dissimilar). Additionally, inorganic nutrient levels steadily increased with depth at LSI but not at LC. Based on bulk stable isotopic variability, sponges collected from LC were generally more enriched in (15) N and less enriched in (13) C as depth increased, suggesting a transition from dependency on photoautotrophy to heterotrophy as depth increased. Patterns of stable isotopic enrichment were largely invariant at LSI, which is also reflected in the more stable microbial community along the depth gradient. It appears that environmental factors that change with depth may contribute to differences in X. muta microbial assemblages, demonstrating the importance of contemporaneous environmental sampling in studies of the microbiome of sponges. © 2016 Society for Applied Microbiology and John Wiley & Sons Ltd.

  6. Hydrophobization of polymer particles by tetrafluoromethane (CF4) plasma irradiation using a barrel-plasma-treatment system

    Science.gov (United States)

    Matsubara, Keisuke; Danno, Masato; Inoue, Mitsuhiro; Nishizawa, Hideki; Honda, Yuji; Abe, Takayuki

    2013-11-01

    In this study, tetrafluoromethane (CF4) plasma-treatments of polymethylmethacrylate (PMMA) powder were performed using a polygonal barrel-plasma-treatment system to improve the PMMA's hydrophobicity. Characterization of the treated samples showed that the PMMA particle surfaces were fluorinated by the CF4 treatment. The smooth surfaces of the particles changed into nano-sized worm-like structures after the plasma-treatment. The hydrophobicity of the treated PMMA samples was superior to that of the untreated samples. It was noted that the hydrophobicity of the treated samples and the surface fluorination level depended on the plasma-treatment time and radiofrequency (RF) power; high RF power increased the sample temperature, which in turn decreased the hydrophobicity of the treated samples and the surface fluorination because of the thermal decomposition of PMMA. The water-repellent effects were evaluated by using paper towels to show the application of the plasma-treated PMMA particles, with the result that the paper towel coated with the treated sample was highly water-repellent.

  7. Hydrophobization of polymer particles by tetrafluoromethane (CF{sub 4}) plasma irradiation using a barrel-plasma-treatment system

    Energy Technology Data Exchange (ETDEWEB)

    Matsubara, Keisuke; Danno, Masato; Inoue, Mitsuhiro; Nishizawa, Hideki; Honda, Yuji; Abe, Takayuki, E-mail: tabe@ctg.u-toyama.ac.jp

    2013-11-01

    In this study, tetrafluoromethane (CF{sub 4}) plasma-treatments of polymethylmethacrylate (PMMA) powder were performed using a polygonal barrel-plasma-treatment system to improve the PMMA's hydrophobicity. Characterization of the treated samples showed that the PMMA particle surfaces were fluorinated by the CF{sub 4} treatment. The smooth surfaces of the particles changed into nano-sized worm-like structures after the plasma-treatment. The hydrophobicity of the treated PMMA samples was superior to that of the untreated samples. It was noted that the hydrophobicity of the treated samples and the surface fluorination level depended on the plasma-treatment time and radiofrequency (RF) power; high RF power increased the sample temperature, which in turn decreased the hydrophobicity of the treated samples and the surface fluorination because of the thermal decomposition of PMMA. The water-repellent effects were evaluated by using paper towels to show the application of the plasma-treated PMMA particles, with the result that the paper towel coated with the treated sample was highly water-repellent.

  8. Harm reduction through a social justice lens.

    Science.gov (United States)

    Pauly, Bernadette

    2008-02-01

    People who are street involved such as those experiencing homelessness and drug use face multiple inequities in health and access to health care. Morbidity and mortality are significantly increased among those who are street involved. Incorporation of a harm reduction philosophy in health care has the potential to shift the moral context of health care delivery and enhance access to health care services. However, harm reduction with a primary focus on reducing the harms of drug use fails focus on the harms associated with the context of drug use such as homelessness, violence and poverty. Ethical analysis of the underlying values of harm reduction and examination of different conceptions of justice are discussed as a basis for action that addresses a broad range of harms associated with drug use. Theories of distributive justice that focus primarily on the distribution of material goods are limited as theoretical frameworks for addressing the root causes of harm associated with drug use. Social justice, reconceptualised and interpreted through a critical lens as described by Iris Marion Young, is presented as a promising alternative ethical framework. A critical reinterpretation of social justice leads to insights that can illuminate structural inequities that contribute to the harms associated with the context of drug use. Such an approach provides promise as means of informing policy that aims to reduce a broad range of harms associated with drug use such as homelessness and poverty.

  9. Acoustic lens for capacitive micromachined ultrasonic transducers

    Science.gov (United States)

    Chang, Chienliu; Firouzi, Kamyar; Park, Kwan Kyu; Sarioglu, Ali Fatih; Nikoozadeh, Amin; Yoon, Hyo-Seon; Vaithilingam, Srikant; Carver, Thomas; Khuri-Yakub, Butrus T.

    2014-08-01

    Capacitive micromachined ultrasonic transducers (CMUTs) have great potential to compete with traditional piezoelectric transducers in therapeutic ultrasound applications. In this paper we have designed, fabricated and developed an acoustic lens formed on the CMUT to mechanically focus ultrasound. The acoustic lens was designed based on the paraxial theory and made of silicone rubber for acoustic impedance matching and encapsulation. The CMUT was fabricated based on the local oxidation of silicon (LOCOS) and fusion-bonding. The fabricated CMUT was verified to behave like an electromechanical resonator in air and exhibited wideband response with a center frequency of 2.2 MHz in immersion. The fabrication for the acoustic lens contained two consecutive mold castings and directly formed on the surface of the CMUT. Applied with ac burst input voltages at the center frequency, the CMUT with the acoustic lens generated an output pressure of 1.89 MPa (peak-to-peak) at the focal point with an effective focal gain of 3.43 in immersion. Compared to the same CMUT without a lens, the CMUT with the acoustic lens demonstrated the ability to successfully focus ultrasound and provided a viable solution to the miniaturization of the multi-modality forward-looking endoscopes without electrical focusing.

  10. Acoustic lens for capacitive micromachined ultrasonic transducers

    International Nuclear Information System (INIS)

    Chang, Chienliu; Firouzi, Kamyar; Sarioglu, Ali Fatih; Nikoozadeh, Amin; Yoon, Hyo-Seon; Vaithilingam, Srikant; Carver, Thomas; Khuri-Yakub, Butrus T; Kyu Park, Kwan

    2014-01-01

    Capacitive micromachined ultrasonic transducers (CMUTs) have great potential to compete with traditional piezoelectric transducers in therapeutic ultrasound applications. In this paper we have designed, fabricated and developed an acoustic lens formed on the CMUT to mechanically focus ultrasound. The acoustic lens was designed based on the paraxial theory and made of silicone rubber for acoustic impedance matching and encapsulation. The CMUT was fabricated based on the local oxidation of silicon (LOCOS) and fusion-bonding. The fabricated CMUT was verified to behave like an electromechanical resonator in air and exhibited wideband response with a center frequency of 2.2 MHz in immersion. The fabrication for the acoustic lens contained two consecutive mold castings and directly formed on the surface of the CMUT. Applied with ac burst input voltages at the center frequency, the CMUT with the acoustic lens generated an output pressure of 1.89 MPa (peak-to-peak) at the focal point with an effective focal gain of 3.43 in immersion. Compared to the same CMUT without a lens, the CMUT with the acoustic lens demonstrated the ability to successfully focus ultrasound and provided a viable solution to the miniaturization of the multi-modality forward-looking endoscopes without electrical focusing. (paper)

  11. LENS: Science Scope and Development Stages

    Science.gov (United States)

    Vogelaar, R. Bruce

    2013-04-01

    The Low-Energy Neutrino Spectroscopy (LENS) experiment will resolve the solar metallicity question via measurement of the CNO neutrino flux, as well as test the predicted equivalence of solar luminosity as measured by photon versus neutrinos. The LENS detector uses charged-current interaction of neutrinos on Indium-115 (loaded in a scintillator, InLS) to reveal the complete solar neutrino spectrum. LENS's optically segmented 3D lattice geometry achieves precise time and spatial resolution and unprecedented background rejection and sensitivity for low-energy neutrino events. This first-of-a-kind lattice design is also suited for a range of other applications where high segmentation and large light collection are required (eg: sterile neutrinos with sources, double beta decay, and surface detection of reactor neutrinos). The physics scope, detector design, and logic driving the microLENS and miniLENS prototyping stages will be presented. The collaboration is actively running programs; building, operating, developing, and simulating these prototypes using the Kimballton Underground Research Facility (KURF). New members are welcome to the LENS Collaboration, and interested parties should contact R. Bruce Vogelaar.

  12. Assessment of Water Quality in Roof-Harvested Rainwater Barrels in Greater Philadelphia

    Directory of Open Access Journals (Sweden)

    Kerry A. Hamilton

    2018-01-01

    Full Text Available A study of water quality parameters was conducted in 38 small-scale roof-harvested rainwater barrels (RHRB located in urban and peri-urban Philadelphia, USA in winter (November–December 2014 and summer (June–August 2016. Parameters included two fecal indicator bacteria (FIB (Escherichia coli and Enterococcus spp. measured using culture-based methods, eight potential enteric and opportunistic pathogens (Campylobacter jejuni, Acanthamoeba spp., Legionella spp., L. pneumophila, Naegleria fowleri, Pseudomonas aeruginosa, Mycobacterium avium and Mycobacterium intracellulare measured using quantitative polymerase chain reaction (qPCR, and two metals (lead and zinc using inductively coupled plasma mass spectrometry (ICP-MS. Fecal indicator bacteria were detected in greater than 60% RHRB samples and concentrations (up to >103 per 100 mL exceeded US Food and Drug Administration (USFDA irrigation water quality standards. Among the enteric and opportunistic pathogens tested, 57.9, 44.7, 21.1, 18.4, 5 and 3% were PCR positive for Legionella spp., M. intracellulare, M. avium, Acanthamoeba spp., P. aeruginosa, and C. jejuni, respectively. N. fowleri and L. pneumophila were not detected in any sample. The concentrations of enteric and opportunistic pathogens ranged from 102 to 107 gene copies/L of barrel water. Lead and zinc were each observed in 88.5% of RHRB but the concentrations did not exceed US Environmental Protection Agency (USEPA standards for irrigating produce, with the exception of one zinc observation (2660 µg/L. Based on these data, it appears that the risk associated with metals in RHRB is likely to be low, as these barrels are only used for gardening and non-potable purposes. However, risks due to fecal and opportunistic pathogens may be higher due to exposure to aerosols during gardening activities and produce consumed raw, and should be investigated further.

  13. The design and performance of a twenty barrel hydrogen pellet injector for Alcator C-Mod

    International Nuclear Information System (INIS)

    Urbahn, J.A.

    1994-05-01

    A twenty barrel hydrogen pellet injector has been designed, built and tested both in the laboratory and on the Alcator C-Mod Tokamak at MIT. The injector functions by firing pellets of frozen hydrogen or deuterium deep into the plasma discharge for the purpose of fueling the plasma, modifying the density profile and increasing the global energy confinement time. The design goals of the injector are: (1) Operational flexibility, (2) High reliability, (3) Remote operation with minimal maintenance. These requirements have lead to a single stage, pipe gun design with twenty barrels. Pellets are formed by in- situ condensation of the fuel gas, thus avoiding moving parts at cryogenic temperatures. The injector is the first to dispense with the need for cryogenic fluids and instead uses a closed cycle refrigerator to cool the thermal system components. The twenty barrels of the injector produce pellets of four different size groups and allow for a high degree of flexibility in fueling experiments. Operation of the injector is under PLC control allowing for remote operation, interlocked safety features and automated pellet manufacturing. The injector has been extrusively tested and shown to produce pellets reliably with velocities up to 1400 m/sec. During the period from September to November of 1993, the injector was successfully used to fire pellets into over fifty plasma discharges. Experimental results include data on the pellet penetration into the plasma using an advanced pellet tracking diagnostic with improved time and spatial response. Data from the tracker indicates pellet penetrations were between 30 and 86 percent of the plasma minor radius

  14. The drift velocity monitoring system of the CMS barrel muon chambers

    Science.gov (United States)

    Altenhöfer, Georg; Hebbeker, Thomas; Heidemann, Carsten; Reithler, Hans; Sonnenschein, Lars; Teyssier, Daniel

    2018-04-01

    The drift velocity is a key parameter of drift chambers. Its value depends on several parameters: electric field, pressure, temperature, gas mixture, and contamination, for example, by ambient air. A dedicated Velocity Drift Chamber (VDC) with 1-L volume has been built at the III. Phys. Institute A, RWTH Aachen, in order to monitor the drift velocity of all CMS barrel muon Drift Tube chambers. A system of six VDCs was installed at CMS and has been running since January 2011. We present the VDC monitoring system, its principle of operation, and measurements performed.

  15. Study of RPC Barrel maximum efficiency in 2012 and 2015 calibration collision runs

    CERN Document Server

    Cassar, Samwel

    2015-01-01

    The maximum efficiency of each of the 1020 Resistive Plate Chamber (RPC) rolls in the barrel region of the CMS muon detector is calculated from the best sigmoid fit of efficiency against high voltage (HV). Data from the HV scans, collected during calibration runs in 2012 and 2015, were compared and the rolls exhibiting a change in maximum efficiency were identified. The chi-square value of the sigmoid fit for each roll was considered in determining the significance of the maximum efficiency for the respective roll.

  16. Upgrade of the CMS muon trigger system in the barrel region

    Energy Technology Data Exchange (ETDEWEB)

    Rabady, Dinyar, E-mail: dinyar.rabady@cern.ch [Institute of High Energy Physics Vienna (HEPHY), Nikolsdorfer Gasse 18, 1050 Wien (Austria); Ero, Janos [Institute of High Energy Physics Vienna (HEPHY), Nikolsdorfer Gasse 18, 1050 Wien (Austria); Flouris, Giannis [University of Ioannina, 45110 Ioannina (Greece); Fulcher, Jonathan [CERN, 1211 Geneve 23 (Switzerland); Loukas, Nikitas; Paradas, Evangelos [University of Ioannina, 45110 Ioannina (Greece); Reis, Thomas; Sakulin, Hannes; Wulz, Claudia-Elisabeth [CERN, 1211 Geneve 23 (Switzerland)

    2017-02-11

    To maintain the excellent performance shown during the LHC's Run-1 the Level-1 Trigger of the Compact Muon Solenoid experiment underwent a significant upgrade. One part of this upgrade is the re-organization of the muon trigger path from a subsystem-centric view in which hits in the drift tubes (DT), the cathode strip chambers (CSC), and the resistive plate chambers (RPC) were treated separately in dedicated track-finding systems to one in which complementary detector systems for a given region (barrel, overlap, and endcap) are merged at the track-finding level. This fundamental restructuring of the muon trigger system required the development of a system to receive track candidates from the track-finding layer, remove potential duplicate tracks, and forward the best candidates to the global decision layer. An overview will be given of the new track-finder system for the barrel region, the Barrel Muon Track Finder (BMTF), as well as the cancel-out and sorting layer: the upgraded Global Muon Trigger (μGMT). Both the BMTF and μGMT have been implemented in a Xilinx Virtex-7 card utilizing the microTCA architecture. While the BMTF improves on the proven and well-tested algorithms used in the Drift Tube Track Finder during Run-1, the μGMT is an almost complete re-development due to the re-organization of the underlying systems from track-finders for a specific detector to regional track finders covering a given area of the whole detector. Additionally the μGMT calculates a muon's isolation using energy information received from the calorimeter trigger. This information is added to the muon objects forwarded to the global decision layer, the so-called Global Trigger. - Highlights: • Presented upgraded Global Muon Trigger and Barrel Muon Track Finder systems. • Upgraded system moves from sub-detector centric view to geometric-view. • To improve trigger performance. • Common hardware improves maintainability and increases development speed. • Use of

  17. Evaporating short-circuits in the ATLAS liquid argon barrel presampler 006

    CERN Document Server

    Belhorma, B; Lund-Jensen, B; Rydström, S; Yamouni, M

    2005-01-01

    A technique to eliminate or limit the implications of short-circuits in the ATLAS barrel presampler is described. A high voltage capacitor with a large capacity is charged at different high voltages and discharged through the short-circuit which allows either to disintegrate the dust being the origin of the short-circuit, or to burn away a thin etched copper strip which acts as a fuse on the corresponding presampler anode. This effect is possible even in the presence of a resistive HV cable (10 to 30 ohms) in series which dampens the pulse.

  18. Design studies for the Phase II upgrade of the CMS Barrel Electromagnetic Calorimeter

    Science.gov (United States)

    Bornheim, A.

    2017-03-01

    The High Luminosity LHC (HL-LHC) aims to reach the unprecedented integrated luminosity of 3 ab-1 with an instantaneous luminosity up to 5 × 1034 cm-2 s-1. This poses stringent requirements on the radiation resistance of detector components and on the latency of the trigger system. The barrel region of the CMS Electromagnetic Calorimeter will be able to retain the current lead tungstate crystals and avalanche photo diode detectors which will meet the performance requirements throughout the operational lifetime of the HL-LHC. The new front-end electronics and very front-end system required at high luminosities will be described.

  19. The inclusion of RPC only segments in the Barrel Muon Track Finder

    CERN Document Server

    CMS Collaboration

    2018-01-01

    On November 3, 2017 during the LHC fill 6360 and from the run number 306121 RPC-only segments were enable to trigger. In this document we show the impact of the RPC-only segments in the Barrel Muon Track Finder efficiency performance. The efficiency measurement was done with Tag and Probe cut and count following the Muon POG working point recommendations (tight ID and Particle Flow isolation requirements more details can be found in https://cds.cern.ch/record/2054113). The used dataset was ZMuMu corresponding to each period.

  20. Projects to get you off the grid rain barrels, chicken coops, and solar panels

    CERN Document Server

    Instructablescom

    2014-01-01

    Instructables is back with this compact book focused on a series of projects designed to get you thinking creatively about thinking green. Twenty Instructables illustrate just how simple it can be to make your own backyard chicken coop, or turn a wine barrel into a rainwater collector.Illustrated with dozens of full-color photographs per project accompanying easy-to-follow instructions, this Instructables collection utilizes the best that the online community has to offer, turning a far-reaching group of people into a mammoth database churning out ideas to make life better, easier, and in this

  1. Upgrade of the CMS muon trigger system in the barrel region

    International Nuclear Information System (INIS)

    Rabady, Dinyar; Ero, Janos; Flouris, Giannis; Fulcher, Jonathan; Loukas, Nikitas; Paradas, Evangelos; Reis, Thomas; Sakulin, Hannes; Wulz, Claudia-Elisabeth

    2017-01-01

    To maintain the excellent performance shown during the LHC's Run-1 the Level-1 Trigger of the Compact Muon Solenoid experiment underwent a significant upgrade. One part of this upgrade is the re-organization of the muon trigger path from a subsystem-centric view in which hits in the drift tubes (DT), the cathode strip chambers (CSC), and the resistive plate chambers (RPC) were treated separately in dedicated track-finding systems to one in which complementary detector systems for a given region (barrel, overlap, and endcap) are merged at the track-finding level. This fundamental restructuring of the muon trigger system required the development of a system to receive track candidates from the track-finding layer, remove potential duplicate tracks, and forward the best candidates to the global decision layer. An overview will be given of the new track-finder system for the barrel region, the Barrel Muon Track Finder (BMTF), as well as the cancel-out and sorting layer: the upgraded Global Muon Trigger (μGMT). Both the BMTF and μGMT have been implemented in a Xilinx Virtex-7 card utilizing the microTCA architecture. While the BMTF improves on the proven and well-tested algorithms used in the Drift Tube Track Finder during Run-1, the μGMT is an almost complete re-development due to the re-organization of the underlying systems from track-finders for a specific detector to regional track finders covering a given area of the whole detector. Additionally the μGMT calculates a muon's isolation using energy information received from the calorimeter trigger. This information is added to the muon objects forwarded to the global decision layer, the so-called Global Trigger. - Highlights: • Presented upgraded Global Muon Trigger and Barrel Muon Track Finder systems. • Upgraded system moves from sub-detector centric view to geometric-view. • To improve trigger performance. • Common hardware improves maintainability and increases development speed. • Use of

  2. The drift velocity monitoring system of the CMS barrel muon chambers

    CERN Document Server

    Altenhoefer, Georg Friedrich; Heidemann, Carsten Andreas; Reithler, Hans; Sonnenschein, Lars; Teyssier, Daniel Francois

    2017-01-01

    The drift velocity is a key parameter of drift chambers. Its value depends on several parameters: electric field, pressure, temperature, gas mixture, and contamination, for example, by ambient air. A dedicated Velocity Drift Chamber (VDC) with 1-L volume has been built at the III. Phys. Institute A, RWTH Aachen, in order to monitor the drift velocity of all CMS barrel muon Drift Tube chambers. A system of six VDCs was installed at CMS and has been running since January 2011. We present the VDC monitoring system, its principle of operation, and measurements performed.

  3. High precision, low disturbance calibration of the High Voltage system of the CMS Barrel Electromagnetic Calorimeter

    CERN Document Server

    Marzocchi, Badder

    2017-01-01

    The CMS Electromagnetic Calorimeter is made of scintillating lead tungstate crystals, using avalanche photodiodes (APD) as photo-detectors in the barrel part. The high voltage system, consisting of 1224 channels, biases groups of 50 APD pairs, each at a voltage of about 380 V. The APD gain dependence on the voltage is 3pct/V. A stability of better than 60 mV is needed to have negligible impact on the calorimeter energy resolution. Until 2015 manual calibrations were performed yearly. A new calibration system was deployed recently, which satisfies the requirement of low disturbance and high precision. The system is discussed in detail and first operational experience is presented.

  4. High precision, low disturbance calibration of the High Voltage system of the CMS Barrel Electromagnetic Calorimeter

    CERN Document Server

    Fasanella, Giuseppe

    2016-01-01

    The CMS Electromagnetic Calorimeter utilizes scintillating lead tungstate crystals, with avalanche photodiodes (APD) as photo-detectors in the barrel part. 1224 HV channels bias groups of 50 APD pairs, each at a voltage of about 380 V. The APD gain dependence on the voltage is 3pct/V. A stability of better than 60 mV is needed to have negligible impact on the calorimeter energy resolution. Until 2015 manual calibrations were performed yearly. A new calibration system was deployed recently, which satisfies the requirement of low disturbance and high precision. The system is discussed in detail and first operational experience is presented.

  5. Fabrication and Tests of M240 Machine Gun Barrels Lined with Stellite 25

    Science.gov (United States)

    2016-04-01

    medical implant industry . The CCM in the name stands for Co, Cr, and Mo. The alloy will hereafter be referred to as Biodur. Table A-1 Biodur CCM...potential for use as gun barrel liners, as demonstrated in recent work.1 The supposition was that since Biodur was a cobalt- chromium alloy , it would also...liner; reducing the carbon content would make the new alloy more machineable. The plan was to cold-spray the special powder into tubes to be used in

  6. The Crystal Barrel: Meson Spectroscopy at LEAR with a 4$\\pi$ Detector

    CERN Multimedia

    2002-01-01

    % PS197 \\\\ \\\\The Crystal Barrel is a 4$\\pi$ spectrometer designed to provide complete and precise information on practically every final state produced in $\\bar{p} p $ and $\\bar{p}d $ annihilations at low energy and to collect high statistics data samples. Selective triggers can be applied when necessary. \\\\ \\\\The physics goal is to identify all light mesons in the mass range from 0.14 to 2.3~GeV/c$^{2}$, to determine their quantum numbers and decay properties and to study the annihilation dynamics. The main interest is to find the glueball and hybrid degrees of freedom predicted in the framework of Quantum Chromodynamics. \\\\ \\\\\

  7. Sharing of secondary electrons by in-lens and out-lens detector in low-voltage scanning electron microscope equipped with immersion lens.

    Science.gov (United States)

    Kumagai, Kazuhiro; Sekiguchi, Takashi

    2009-03-01

    To understand secondary electron (SE) image formation with in-lens and out-lens detector in low-voltage scanning electron microscopy (LV-SEM), we have evaluated SE signals of an in-lens and an out-lens detector in LV-SEM. From the energy distribution spectra of SEs with various boosting voltages of the immersion lens system, we revealed that the electrostatic field of the immersion lens mainly collects electrons with energy lower than 40eV, acting as a low-pass filter. This effect is also observed as a contrast change in LV-SEM images taken by in-lens and out-lens detectors.

  8. Acanthamoeba keratitis and contact lens wear.

    Science.gov (United States)

    Lindsay, Richard G; Watters, Grant; Johnson, Richard; Ormonde, Susan E; Snibson, Grant R

    2007-09-01

    Acanthamoeba keratitis is a rare but serious complication of contact lens wear that may cause severe visual loss. The clinical picture is usually characterised by severe pain, sometimes disproportionate to the signs, with an early superficial keratitis that is often misdiagnosed as herpes simplex virus (HSV) keratitis. Advanced stages of the infection are usually characterised by central corneal epithelial loss and marked stromal opacification with subsequent loss of vision. In this paper, six cases of contact lens-related Acanthamoeba keratitis that occurred in Australia and New Zealand over a three-year period are described. Three of the patients were disposable soft lens wearers, two were hybrid lens wearers and one was a rigid gas permeable lens wearer. For all six cases, the risk factors for Acanthamoeba keratitis were contact lens wear with inappropriate or ineffective lens maintenance and exposure of the contact lenses to tap or other sources of water. All six patients responded well to medical therapy that involved topical use of appropriate therapeutic agents, most commonly polyhexamethylene biguanide and propamidine isethionate, although two of the patients also subsequently underwent deep lamellar keratoplasty due to residual corneal surface irregularity and stromal scarring. Despite the significant advances that have been made in the medical therapy of Acanthamoeba keratitis over the past 10 years, prevention remains the best treatment and patients who wear contact lenses must be thoroughly educated about the proper use and care of the lenses. In particular, exposure of the contact lenses to tap water or other sources of water should be avoided.

  9. CRITICAL CURVES AND CAUSTICS OF TRIPLE-LENS MODELS

    International Nuclear Information System (INIS)

    Daněk, Kamil; Heyrovský, David

    2015-01-01

    Among the 25 planetary systems detected up to now by gravitational microlensing, there are two cases of a star with two planets, and two cases of a binary star with a planet. Other, yet undetected types of triple lenses include triple stars or stars with a planet with a moon. The analysis and interpretation of such events is hindered by the lack of understanding of essential characteristics of triple lenses, such as their critical curves and caustics. We present here analytical and numerical methods for mapping the critical-curve topology and caustic cusp number in the parameter space of n-point-mass lenses. We apply the methods to the analysis of four symmetric triple-lens models, and obtain altogether 9 different critical-curve topologies and 32 caustic structures. While these results include various generic types, they represent just a subset of all possible triple-lens critical curves and caustics. Using the analyzed models, we demonstrate interesting features of triple lenses that do not occur in two-point-mass lenses. We show an example of a lens that cannot be described by the Chang–Refsdal model in the wide limit. In the close limit we demonstrate unusual structures of primary and secondary caustic loops, and explain the conditions for their occurrence. In the planetary limit we find that the presence of a planet may lead to a whole sequence of additional caustic metamorphoses. We show that a pair of planets may change the structure of the primary caustic even when placed far from their resonant position at the Einstein radius

  10. Properties of the cathode lens combined with a focusing magnetic/immersion-magnetic lens

    International Nuclear Information System (INIS)

    Konvalina, I.; Muellerova, I.

    2011-01-01

    The cathode lens is an electron optical element in an emission electron microscope accelerating electrons from the sample, which serves as a source for a beam of electrons. Special application consists in using the cathode lens first for retardation of an illuminating electron beam and then for acceleration of reflected as well as secondary electrons, made in the directly imaging low energy electron microscope or in its scanning version discussed here. In order to form a real image, the cathode lens has to be combined with a focusing magnetic lens or a focusing immersion-magnetic lens, as used for objective lenses of some commercial scanning electron microscopes. These two alternatives are compared with regards to their optical properties, in particular with respect to predicted aberration coefficients and the spot size, as well as the optimum angular aperture of the primary beam. The important role of the final aperture size on the image resolution is also presented.

  11. Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN.

    Science.gov (United States)

    Anand, Arvind; LeDoyt, Morgan; Karanian, Carson; Luthra, Amit; Koszelak-Rosenblum, Mary; Malkowski, Michael G; Puthenveetil, Robbins; Vinogradova, Olga; Radolf, Justin D

    2015-05-08

    We previously identified Treponema pallidum repeat proteins TprC/D, TprF, and TprI as candidate outer membrane proteins (OMPs) and subsequently demonstrated that TprC is not only a rare OMP but also forms trimers and has porin activity. We also reported that TprC contains N- and C-terminal domains (TprC(N) and TprC(C)) orthologous to regions in the major outer sheath protein (MOSP(N) and MOSP(C)) of Treponema denticola and that TprC(C) is solely responsible for β-barrel formation, trimerization, and porin function by the full-length protein. Herein, we show that TprI also possesses bipartite architecture, trimeric structure, and porin function and that the MOSP(C)-like domains of native TprC and TprI are surface-exposed in T. pallidum, whereas their MOSP(N)-like domains are tethered within the periplasm. TprF, which does not contain a MOSP(C)-like domain, lacks amphiphilicity and porin activity, adopts an extended inflexible structure, and, in T. pallidum, is tightly bound to the protoplasmic cylinder. By thermal denaturation, the MOSP(N) and MOSP(C)-like domains of TprC and TprI are highly thermostable, endowing the full-length proteins with impressive conformational stability. When expressed in Escherichia coli with PelB signal sequences, TprC and TprI localize to the outer membrane, adopting bipartite topologies, whereas TprF is periplasmic. We propose that the MOSP(N)-like domains enhance the structural integrity of the cell envelope by anchoring the β-barrels within the periplasm. In addition to being bona fide T. pallidum rare outer membrane proteins, TprC/D and TprI represent a new class of dual function, bipartite bacterial OMP. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. Qualification of barrel pixel detector modules for the Phase 1 Upgrade of the CMS vertex detector

    CERN Document Server

    Kudella, Simon

    2016-01-01

    To withstand the higher particle rates of LHC Runs 2 and 3, with expected luminosities of up to $2\\times 10^{34}\\,\\mathrm{cm^{-2}s^{-1}}$, the current CMS pixel detector at the LHC will be replaced as part of the CMS Phase I Upgrade during the extended winter shutdown in 2016/17. The new pixel detector features a new geometry with one additional detector layer in the barrel region~(BPIX) and one pair of additional disks in the forward region~(FPIX), new digital readout chips as well as a new CO$_{2}$-based cooling system for both the barrel and forward region. The BPIX detector module production is summarized, with special focus on the different stages of quality assurance. The quality tests as well as the calibrations which all produced modules undergo in a temperature and humidity controlled environment are described. Exemplarily, the KIT/Aachen production line and its subprocesses are presented together with its quality and yields.

  13. A New Data Concentrator for the CMS Muon Barrel Track Finder

    CERN Document Server

    Triossi, Andrea

    2014-01-01

    The CMS muon trigger will undergo considerable enhancements in preparation for the LHC \\mbox{run-2}. In order to improve rate reduction and efficiency the full muon trigger chain will be completely redesigned: the plan is to move from a redundant scheme, where the three subdetectors (CSC, DT, RPC) have a separate track finder, to three geographical track finders (barrel, endcap and overlap) that combine trigger primitives of each sub-detector. In particular, the muon barrel track finder (MBTF) will host a new algorithm, that aggregating DT and RPC trigger data, will be able to improve the fake rejection and the muon momentum measurement.This report will focus on the adaptive layer of the MBTF called TwinMux. Its primary role will be to merge, arrange and fan-out the slow optical links from the chambers in faster links (10 Gbps). It will realize a full connectivity matrix between the on-detector electronics and the MBTF allowing for different processing schemes. The TwinMux will be implemented in $\\mu$TCA for...

  14. Upgrade of the ATLAS Muon Barrel Trigger for HL-LHC.

    CERN Document Server

    Biondi, Silvia; The ATLAS collaboration

    2015-01-01

    The present ATLAS muon trigger in the barrel region (|η | < 1.05) is based on three layers of RPC chambers. It was designed to run for 10 years at the LHC luminosity of 1034cm−2s−1 and operated successfully and with high selectivity during the first run of the LHC. In order to ensure a stable performance of the RPCs until 2035 at the higher rates and at luminosities of 5−7x1034cm−2s−1 provided by HL-LHC, the chambers will have to be operated with reduced gas gain to respect the original design limits on currents and integrated charge. The ATLAS muon collaboration proposes an upgrade of the system by installing an inner layer of new generation RPCs during the LHC shutdown expected for the year 2023. This new layer will increase the system redundancy and therefore allow operation with high efficiency and high selectivity during the HL-LHC phase. The insertion of this new layer will also increase the geometrical acceptance in the barrel region from 75% to 95%. Moreover, the additional measurements ...

  15. Chloride Transport through Supramolecular Barrel-Rosette Ion Channels: Lipophilic Control and Apoptosis-Inducing Activity.

    Science.gov (United States)

    Saha, Tanmoy; Gautam, Amitosh; Mukherjee, Arnab; Lahiri, Mayurika; Talukdar, Pinaki

    2016-12-21

    Despite the great interest in artificial ion channel design, only a small number of channel-forming molecules are currently available for addressing challenging problems, particularly in the biological systems. Recent advances in chloride-mediated cell death, aided by synthetic ion carriers, encouraged us to develop chloride selective supramolecular ion channels. The present work describes vicinal diols, tethered to a rigid 1,3-diethynylbenzene core, as pivotal moieties for the barrel-rosette ion channel formation, and the activity of such channels was tuned by controlling the lipophilicity of designed monomers. Selective transport of chloride ions via an antiport mechanism and channel formation in the lipid bilayer membranes were confirmed for the most active molecule. A theoretical model of the supramolecular barrel-rosette, favored by a network of intermolecular hydrogen bonding, has been proposed. The artificial ion-channel-mediated transport of chloride into cells and subsequent disruption of cellular ionic homeostasis were evident. Perturbation of chloride homeostasis in cells instigates cell death by inducing the caspase-mediated intrinsic pathway of apoptosis.

  16. Gamma ray scanner systems for nondestructive assay of heterogeneous waste barrels

    International Nuclear Information System (INIS)

    Martz, H.E.; Decman, B.J.; Roberson, G.P.; Levai, F.

    1997-01-01

    Traditional gamma safeguards measurements have usually been performed using a segmented gamma scanning (SGS) system. The accuracy of this technique relies on the assumption that the sample matrix and the activity are both uniform for a segment. Waste barrels are often highly heterogeneous, span a wide range of composition and matrix type. The primary sources of error are all directly or indirectly related to a non-uniform measurement response associated with unknown radioactive source spatial distribution and heterogeneity of the matrix. These errors can be significantly reduced by some imaging techniques that measure exact spatial locations of sources and attenuation maps. In this paper we describe a joint R ampersand D effort between the Lawrence Livermore National Laboratory (LLNL) and the Institute of Nuclear Techniques (INT) of the Technical University, Budapest, to compare results obtained by two different gamma-ray nondestructive assay (NDA) systems used for imaging waste barrels. The basic principles are the same, but the approaches are different. Key factors to judge the adequacy of a method are the detection limit and the accuracy. Test drums representing waste to be measured are used to determine basic parameters of these techniques

  17. Insertion of the first half-barrel of the ATLAS electromagnetic calorimeter into its cryostat

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The first cylinder of the ATLAS electromagnetic calorimeter barrel and the presampler have been inserted in the cryostat.The ATLAS electromagnetic calorimeter is intended to detect electrons, positrons and photons by measuring the energy they deposit on being absorbed. The cylinder of the calorimeter is in two halves, that will be sunk in a liquid-argon bath cooled to 90 kelvin (-180°C). Each half-barrel is 3.2 metres long, 53 cm thick and formed by assembling 16 modules. Each module is made up of alternate lead absorbers and electrodes pressed into 64 layers folded accordion-fashion. The presampler, set up inside the cylinder, is an integral part of the calorimeter system: It measures the energy lost by a particle before it reaches the calorimeter. To ensure an ultra-clean environment, a tent (visible here) was erected round the calorimeter and entry point to the cryostat. The detector and presampler, fitted together, could then be slid gradually into the cryostat like a drawer. To do so, the insertion team...

  18. Insertion of the first half-barrel of the ATLAS electromagnetic calorimeter into its cryostat

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The first cylinder of the ATLAS electromagnetic calorimeter barrel and the presampler have been inserted in the cryostat. The ATLAS electromagnetic calorimeter is intended to detect electrons, positrons and photons by measuring the energy they deposit on being absorbed. The cylinder of the calorimeter is in two halves, that will be sunk in a liquid-argon bath cooled to 90 kelvin (-180°C). Each half-barrel is 3.2 metres long, 53 cm thick and formed by assembling 16 modules. Each module is made up of alternate lead absorbers and electrodes pressed into 64 layers folded accordion-fashion. The presampler, set up inside the cylinder, is an integral part of the calorimeter system: It measures the energy lost by a particle before it reaches the calorimeter. To ensure an ultra-clean environment, a tent was erected round the calorimeter and entry point to the cryostat. The detector and presampler, fitted together, could then be slid gradually into the cryostat like a drawer. To do so, the insertion team had to fine-t...

  19. The Muon Spectrometer Barrel Level-1 Trigger of the ATLAS Experiment at LHC

    CERN Document Server

    Aloisio, A; Conventi, F; De Asmundis, R; Izzo, V; Migliaccio, A; Ciapetti, G; Di Mattia, A; Luci, C; Luminari, L; Nisati, A; Pastore, F; Petrolo, E; Vari, R; Veneziano, Stefano; Salamon, A

    2006-01-01

    The proton-proton beam crossing at the LHC accelerator at CERN will have a rate of 40 MHz at the project luminosity. The ATLAS Trigger System has been designed in three levels in order to select only interesting physics events reducing from that rate of 40 MHz to the foreseen storage rate of about 200 Hz. The First Level reduces the output rate to about 100 kHz. The ATLAS Muon Spectrometer has been designed to perform stand-alone triggering and measurement of muon transverse momentum up to 1 TeV/c with good resolution (from 3% at 10 GeV/c up to 10% at 1 TeV/c). In the Barrel region of the Muon Spectrometer the Level-1 trigger is given by means of three layers of Resistive Plate Chamber detectors (RPC): a gaseous detector working in avalanche mode composed by two plates of high-resistivity bakelite and two orthogonal planes of read-out strips. The logic of the Level-1 barrel muon trigger is based on the search of patterns of RPC hits in the three layers consistent with a high transverse momentum muon track ori...

  20. Shifts in coding properties and maintenance of information transmission during adaptation in barrel cortex.

    Directory of Open Access Journals (Sweden)

    Miguel Maravall

    2007-02-01

    Full Text Available Neuronal responses to ongoing stimulation in many systems change over time, or "adapt." Despite the ubiquity of adaptation, its effects on the stimulus information carried by neurons are often unknown. Here we examine how adaptation affects sensory coding in barrel cortex. We used spike-triggered covariance analysis of single-neuron responses to continuous, rapidly varying vibrissa motion stimuli, recorded in anesthetized rats. Changes in stimulus statistics induced spike rate adaptation over hundreds of milliseconds. Vibrissa motion encoding changed with adaptation as follows. In every neuron that showed rate adaptation, the input-output tuning function scaled with the changes in stimulus distribution, allowing the neurons to maintain the quantity of information conveyed about stimulus features. A single neuron that did not show rate adaptation also lacked input-output rescaling and did not maintain information across changes in stimulus statistics. Therefore, in barrel cortex, rate adaptation occurs on a slow timescale relative to the features driving spikes and is associated with gain rescaling matched to the stimulus distribution. Our results suggest that adaptation enhances tactile representations in primary somatosensory cortex, where they could directly influence perceptual decisions.

  1. First Test of the Performance of CMS Muon Chambers inside the Barrel Yoke

    CERN Document Server

    Jacobi, Emanuel

    2008-01-01

    The Compact Muon Solenoid (CMS) is a multi purpose experimental particle detector at the Large Hadron Collider (LHC). The goal of this experiment is to do fundamental research in particle physics and in particular to prove the validity of the Higgs model. The CMS muon barrel system provides a precise measurement of the position and the momentum of high energy muons. It consists of 250 drift tube chambers, with rectangular drift cells filled with a gas mixture of 85% Ar and 15%CO$_{2}$. Each chamber is equipped with on-chamber readout and trigger electronics. The chambers for the innermost station have been produced at the Physics Institute IIIA at the RWTH University. After installing the chambers at their final position inside the barrel return yoke for the CMS solenoid magnet, cosmic muons have been recorded individually for all chambers and used to evaluate the detector performance, as this is the last chance to easily access the chambers for hardware interventions. These data also provide a good opportuni...

  2. The common cryogenic test facility for the ATLAS barrel and end-cap toroid magnets

    CERN Document Server

    Delruelle, N; Junker, S; Passardi, Giorgio; Pengo, R; Pirotte, O

    2004-01-01

    The large ATLAS toroidal superconducting magnet made of the Barrel and two End-Caps needs extensive testing at the surface of the individual components prior to their final assembly into the underground cavern of LHC. A cryogenic test facility specifically designed for cooling sequentially the eight coils making the Barrel Toroid (BT) has been fully commissioned and is now ready for final acceptance of these magnets. This facility, originally designed for testing individually the 46 tons BT coils, will be upgraded to allow the acceptance tests of the two End-Caps, each of them having 160 tons cold mass. The integrated system mainly comprises a 1.2 kW@4.5 K refrigerator, a 10 kW liquid-nitrogen precooler, two cryostats housing liquid helium centrifugal pumps of respectively 80 g/s and 600 g/s nominal flow and specific instrumentation to measure the thermal performances of the magnets. This paper describes the overall facility with particular emphasis to the cryogenic features adopted to match the specific requ...

  3. The Common Cryogenic Test Facility for the Atlas Barrel and End-Cap Toroid Magnet

    CERN Document Server

    Delruelle, N; Junker, S; Passardi, Giorgio; Pengo, R; Pirotte, O

    2004-01-01

    The large ATLAS toroidal superconducting magnet made of the Barrel and two End-Caps needs extensive testing at the surface of the individual components prior to their final assembly into the underground cavern of LHC. A cryogenic test facility specifically designed for cooling sequentially the eight coils making the Barrel Toroid (BT) has been fully commissioned and is now ready for final acceptance of these magnets. This facility, originally designed for testing individually the 46 tons BT coils, will be upgraded to allow the acceptance tests of the two End-Caps, each of them having a 160 tons cold mass. The integrated system mainly comprises a 1.2 kW@4.5 K refrigerator, a 10 kW liquid-nitrogen precooler, two cryostats housing liquid helium centrifugal pumps of respectively 80 g/s and 600 g/s nominal flow and specific instrumentation to measure the thermal performances of the magnets. This paper describes the overall facility with particular emphasis to the cryogenic features adopted to match the specific re...

  4. Installation of the Liquid Argon Calorimater Barrel in the ATLAS Experimental Cavern

    CERN Multimedia

    Vandoni, G.

    On the 27th of October, the Liquid Argon Barrel cryostat was transported from Building 180 to point 1. The next day, the Barrel was lowered into the cavern, and was placed on jacks close to its final position inside the completed lower half of the Tile calorimeter. After a day of precise adjustment, it was resting within a few millimetres of its nominal final position, waiting for the upper half of the Tile calorimeter to be installed. Tight requests had been issued by the Liquid Argon collaboration for the whole transport. It was foreseen that the cryostat should not see any acceleration larger than 0.15g along its axis, 0.08g transversally and 0.3g in the vertical direction. In addition, no acceleration higher than 0.03g (or even 0.003g for permanent oscillation) would be allowed at 20Hz, to avoid the risk of damaging the absorbers at this spontaneous vibration frequency. The difficulty would arise when coping these demands with the tortuous route, its slopes and curbs, vibration transmission from the engi...

  5. The CMS Barrel Calorimeter Response to Particle Beams from 2 to 350 GeV/c

    CERN Document Server

    Abdullin, Salavat; Acharya, Bannaje Sripathi; Adam, Nadia; Adams, Mark Raymond; Adzic, Petar; Akchurin, Nural; Akgun, Ugur; Albayrak, Elif Asli; Alemany-Fernandez, Reyes; Almeida, Nuno; Anagnostou, Georgios; Andelin, Daniel; Anderson, E Walter; Anfreville, Marc; Anicin, Ivan; Antchev, Georgy; Antunovic, Zeljko; Arcidiacono, Roberta; Arenton, Michael Wayne; Auffray, Etiennette; Argiro, Stefano; Askew, Andrew; Atramentov, Oleksiy; Ayan, S; Arcidy, M; Aydin, Sezgin; Aziz, Tariq; Baarmand, Marc M; Babich, Kanstantsin; Baccaro, Stefania; Baden, Drew; Baffioni, Stephanie; Bakirci, Mustafa Numan; Balazs, Michael; Banerjee, Sunanda; Banerjee, Sudeshna; Bard, Robert; Barge, Derek; Barnes, Virgil E; Barney, David; Barone, Luciano; Bartoloni, Alessandro; Baty, Clement; Bawa, Harinder Singh; Baiatian, G; Bandurin, Dmitry; Beauceron, Stephanie; Bell, Ken W; Bencze, Gyorgy; Benetta, Robert; Bercher, Michel; Beri, Suman Bala; Bernet, Colin; Berntzon, Lisa; Berthon, Ursula; Besançon, Marc; Betev, Botjo; Beuselinck, Raymond; Bhatnagar, Vipin; Bhatti, Anwar; Biino, Cristina; Blaha, Jan; Bloch, Philippe; Blyth, Simon; Bodek, Arie; Bornheim, Adolf; Bose, Suvadeep; Bose, Tulika; Bourotte, Jean; Brett, Angela Mary; Brown, Robert M; Britton, David; Budd, Howard; Bühler, M; Burchesky, Kyle; Busson, Philippe; Camanzi, Barbara; Camporesi, Tiziano; Cankocak, Kerem; Carrell, Kenneth Wayne; Carrera, E; Cartiglia, Nicolo; Cavallari, Francesca; Cerci, Salim; Cerutti, cM; Chang, Paoti; Chang, You-Hao; Charlot, Claude; Chen, E Augustine; Chen, Wan-Ting; Chen, Zheng-Yu; Chendvankar, Sanjay; Chipaux, Rémi; Choudhary, Brajesh C; Choudhury, Rajani Kant; Chung, Yeon Sei; Clarida, Warren; Cockerill, David J A; Combaret, Christophe; Conetti, Sergio; Cossutti, Fabio; Cox, Bradley; Cremaldi, Lucien Marcus; Cushman, Priscilla; Cussans, David; Dafinei, Ioan; Damgov, Jordan; Da Silva Di Calafiori, Diogo Raphael; Daskalakis, Georgios; Davatz, Giovanna; David, A; De Barbaro, Pawel; Debbins, Paul; Deiters, Konrad; Dejardin, Marc; Djordjevic, Milos; Deliomeroglu, Mehmet; Della Negra, Rodolphe; Della Ricca, Giuseppe; Del Re, Daniele; Demianov, A; De Min, Alberto; Denegri, Daniel; Depasse, Pierre; de Visser, Theo; Descamps, Julien; Deshpande, Pandurang Vishnu; Díaz, Jonathan; Diemoz, Marcella; Di Marco, Emanuele; Dimitrov, Lubomir; Dissertori, Günther; Dittmar, Michael; Djambazov, Lubomir; Dobrzynski, Ludwik; Drndarevic, Snezana; Duboscq, Jean Etienne; Dugad, Shashikant; Dumanoglu, Isa; Duru, Firdevs; Dutta, Dipanwita; Dzelalija, Mile; Efthymiopoulos, I; Elias, John E; Peisert, A; El-Mamouni, H; Elvira, D; Emeliantchik, Igor; Eno, Sarah Catherine; Ershov, Alexander; Erturk, Sefa; Esen, Selda; Eskut, Eda; Evangelou, Ioannis; Evans, David; Fabbro, Bernard; Faure, Jean-Louis; Fay, Jean; Fenyvesi, Andras; Ferri, Federico; Fisher, Wade Cameron; Flower, Paul S; Franci, Daniele; Franzoni, Giovanni; Freeman, Jim; Freudenreich, Klaus; Funk, Wolfgang; Ganjour, Serguei; Gargiulo, Corrado; Gascon, Susan; Gataullin, Marat; Gaultney, Vanessa; Gamsizkan, Halil; Gavrilov, Vladimir; Geerebaert, Yannick; Genchev, Vladimir; Gentit, François-Xavier; Gerbaudo, Davide; Gershtein, Yuri; Ghezzi, Alessio; Ghodgaonkar, Manohar; Gilly, Jean; Givernaud, Alain; Gleyzer, Sergei V; Gninenko, Sergei; Go, Apollo; Gobbo, Benigno; Godinovic, Nikola; Golubev, Nikolai; Golutvin, Igor; Goncharov, Petr; Gong, Datao; Govoni, Pietro; Grant, Nicholas; Gras, Philippe; Grassi, Tullio; Green, Dan; Greenhalgh, R J S; Gribushin, Andrey; Grinev, B; Guevara Riveros, Luz; Guillaud, Jean-Paul; Gurtu, Atul; Murat Guler, A; Gülmez, Erhan; Gümüs, K; Haelen, T; Hagopian, Sharon; Hagopian, Vasken; Haguenauer, Maurice; Halyo, Valerie; Hamel de Monchenault, Gautier; Hansen, Sten; Hashemi, Majid; Hauptman, John M; Hazen, Eric; Heath, Helen F; Heering, Arjan Hendrix; Heister, Arno; Heltsley, Brian; Hill, Jack; Hintz, Wieland; Hirosky, Robert; Hobson, Peter R; Honma, Alan; Hou, George Wei-Shu; Hsiung, Yee; Hunt, Adam; Husejko, Michal; Ille, Bernard; Ilyina, N; Imlay, Richard; Ingram, D; Ingram, Quentin; Isiksal, Engin; Jarry, Patrick; Jarvis, Chad; Jeong, Chiyoung; Jessop, Colin; Johnson, Kurtis F; Jones, John; Jovanovic, Dragoslav; Kaadze, Ketino; Kachanov, Vassili; Kaftanova, V; Kailas, Swaminathan; Kalagin, Vladimir; Kalinin, Alexey; Kalmani, Suresh Devendrappa; Karmgard, Daniel John; Kataria, Sushil Kumar; Kaur, Manjit; Kaya, Mithat; Kaya, Ozlem; Kayis-Topaksu, A; Kellogg, Richard G; Kennedy, Bruce W; Khmelnikov, Alexander; Kim, Heejong; Kisselevich, I; Kloukinas, Kostas; Kodolova, Olga; Kohli, Jatinder Mohan; Kokkas, Panagiotis; Kolberg, Ted; Kolossov, V; Korablev, Andrey; Korneev, Yury; Kosarev, Ivan; Kramer, Laird; Krasnikov, Nikolai; Krinitsyn, Alexander; Krokhotin, Andrey; Krpic, Dragomir; Kryshkin, V; Kubota, Yuichi; Kubrik, A; Kuleshov, Sergey; Kumar, Arun; Kumar, P; Kunori, Shuichi; Kuo, Chen-Cheng; Kurt, Pelin; Kyberd, Paul; Kyriakis, Aristotelis; Laasanen, Alvin T; Ladygin, Vladimir; Laird, Edward; Landsberg, Greg; Laszlo, Andras; Lawlor, C; Lazic, Dragoslav; Lebeau, Michel; Lecomte, Pierre; Lecoq, Paul; Ledovskoy, Alexander; Lee, Sang Joon; Leshev, Georgi; Lethuillier, Morgan; Levchuk, Leonid; Lin, Sheng-Wen; Lin, Willis; Linn, Stephan; Lintern, A L; Litvine, Vladimir; Litvintsev, Dmitri; Litov, Leander; Lobolo, L; Locci, Elizabeth; Lodge, Anthony B; Longo, Egidio; Loukas, Demetrios; Los, Serguei; Lubinsky, V; Luckey, Paul David; Lukanin, Vladimir; Lustermann, Werner; Lynch, Clare; Ma, Yousi; Machado, Emanuel; Mahlke-Krüger, H; Maity, Manas; Majumder, Gobinda; Malberti, Martina; Malclès, Julie; Maletic, Dimitrije; Mandjavidze, Irakli; Mans, Jeremy; Manthos, Nikolaos; Maravin, Yurii; Marchica, Carmelo; Marinelli, Nancy; Markou, Athanasios; Markou, Christos; Marlow, Daniel; Markowitz, Pete; Marone, Matteo; Martínez, German; Mathez, Hervé; Matveev, Viktor; Mavrommatis, Charalampos; Maurelli, Georges; Mazumdar, Kajari; Meridiani, Paolo; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mescheryakov, G; Mestvirishvili, Alexi; Mikhailin, V; Milenovic, Predrag; Miller, Michael; Milleret, Gérard; Miné, Philippe; Möller, A; Mohammadi-Najafabadi, M; Mohanty, Ajit Kumar; Moissenz, P; Mondal, Naba Kumar; Moortgat, Filip; Mossolov, Vladimir; Mur, Michel; Musella, Pasquale; Musienko, Yuri; Nagaraj, P; Nardulli, Alessandro; Nash, Jordan; Nédélec, Patrick; Negri, Pietro; Newman, Harvey B; Nikitenko, Alexander; Norbeck, Edwin; Nessi-Tedaldi, Francesca; Obertino, Maria Margherita; Olson, Jonathan; Onel, Yasar; Onengüt, G; Organtini, Giovanni; Orimoto, Toyoko; Ozkan, Cigdem; Ozkurt, Halil; Ozkorucuklu, Suat; Ozok, Ferhat; Paganoni, Marco; Paganini, Pascal; Paktinat, S; Pal, Andras; Palma, Alessandro; Panev, Bozhidar; Pant, Lalit Mohan; Papadakis, Antonakis; Papadakis, Ioannis; Papadopoulos, Ioannis; Paramatti, Riccardo; Parracho, P; Pastrone, Nadia; Patil, Mandakini Ravindra; Patterson, Juliet Ritchie; Pauss, Felicitas; Penzo, Aldo; Petrakou, Eleni; Petrushanko, Sergey; Petrosian, A; Phillips II, David; Pikalov, Vladimir; Piperov, Stefan; Piroué, Pierre; Podrasky, V; Polatoz, A; Pompos, Arnold; Popescu, Sorina; Posch, C; Pozdnyakov, Andrey; Ptochos, Fotios; Puljak, Ivica; Pullia, Antonino; Punz, Thomas; Puzovic, Jovan; Qian, Weiming; Ragazzi, Stefano; Rahatlou, Shahram; Ralich, Robert; Rande, J; Razis, Panos A; Redaelli, Nicola; Reddy, L; Reidy, Jim; Renker, Dieter; Reucroft, Steve; Reymond, Jean-Marc; Ribeiro, Pedro Quinaz; Röser, Ulf; Rogalev, Evgueni; Rogan, Christopher; Roh, Youn; Rohlf, James; Romanteau, Thierry; Rondeaux, Françoise; Ronquest, Michael; Ronzhin, Anatoly; Rosowsky, André; Rovelli, Chiara; Ruchti, Randy; Rumerio, Paolo; Rusack, Roger; Rusakov, Sergey V; Ryan, Matthew John; Ryazanov, Anton; Safronov, Grigory; Sala, Leonardo; Salerno, Roberto; Sanders, David A; Santanastasio, Francesco; Sanzeni, Christopher; Sarycheva, Ludmila; Satyanarayana, B; Schinzel, Dietrich; Schmidt, Ianos; Seez, Christopher; Sekmen, Sezen; Semenov, Sergey; Senchishin, V; Sergeyev, S; Serin, Meltem; Sever, Ramazan; Sharp, Peter; Shepherd-Themistocleous, Claire; Siamitros, Christos; Sillou, Daniel; Singh, Jas Bir; Singovsky, Alexander; Sirois, Yves; Sirunyan, Albert M; Silva, J; Silva, Pedro; Skuja, Andris; Sharma, Seema; Sherwood, Brian; Shiu, Jing-Ge; Shivpuri, Ram Krishen; Shukla, Prashant; Shumeiko, Nikolai; Smirnov, Vitaly; Smith, Brian; Smith, Vincent J; Sogut, Kenan; Sonmez, Nasuf; Sorokin, Pavel; Spezziga, Mario; Sproston, Martin; Stefanovich, R; Stockli, F; Stolin, Viatcheslav; Sudhakar, Katta; Sulak, Lawrence; Suter, Henry; Suzuki, Ichiro; Swain, John; Tabarellide Fatis, T; Talov, Vladimir; Takahashi, Maiko; Tcheremoukhine, Alexandre; Teller, Olivier; Teplov, Konstantin; Theofilatos, Konstantinos; Thiebaux, Christophe; Thomas, Ray; Timciuc, Vladlen; Timlin, Claire; Titov, Maksym; Tobias, A; Tonwar, Suresh C; Topakli, Huseyin; Topkar, Anita; Triantis, Frixos A; Troshin, Sergey; Tully, Christopher; Turchanovich, L; Tyurin, Nikolay; Ueno, Koji; Ulyanov, A; Uzunian, Andrey; Vanini, A; Vankov, Ivan; Vardanyan, Irina; Varela, F; Varela, Joao; Vasil ev, A; Velasco, Mayda; Vergili, Mehmet; Verma, Piyush; Verrecchia, Patrice; Vesztergombi, Gyorgy; Veverka, Jan; Vichoudis, Paschalis; Vidal, Richard; Virdee, Tejinder; Vishnevskiy, Alexander; Vlassov, E; Vodopiyanov, Igor; Volobouev, Igor; Volkov, Alexey; Volodko, Anton; Von Gunten, Hans Peter; Wang, Lei; Wang, Minzu; Wardrope, David; Weber, Markus; Weng, Joanna; Werner, Jeremy Scott; Wetstein, Matthew; Winn, Dave; Wigmans, Richard; Williams, Jennifer C; Whitmore, Juliana; Won, Steven; Wu, Shouxiang; Yang, Yong; Yaselli, Ignacio; Yazgan, Efe; Yetkin, Taylan; Yohay, Rachel; Zabi, Alexandre; Zálán, Peter; Zamiatin, Nikolai; Zarubin, Anatoli; Zelepoukine, Serguei; Zeyrek, Mehmet; Zhang, Jia-Wen; Zhang, Lin; Zhu, Kejun; Zhu, Ren-Yuan

    2008-01-01

    The response of the CMS barrel calorimeter (electromagnetic plus hadronic) to hadrons, electrons and muons over a wide momentum range from 2 to 350 GeV/c has been measured. To our knowledge, this is the widest range of momenta in which any calorimeter system has been studied. These tests, carried out at the H2 beam-line at CERN, provide a wealth of information, especially at low energies. The analysis of the differences in calorimeter response to charged pions, kaons, protons and antiprotons and a detailed discussion of the underlying phenomena are presented. We also show techniques that apply corrections to the signals from the considerably different electromagnetic (EB) and hadronic (HB) barrel calorimeters in reconstructing the energies of hadrons. Above 5 GeV/c, these corrections improve the energy resolution of the combined system where the stochastic term equals 84.7$\\pm$1.6$\\%$ and the constant term is 7.4$\\pm$0.8$\\%$. The corrected mean response remains constant within 1.3$\\%$ rms.

  6. Lens exposure during brain scans using multidetector row CT scanners: methods for estimation of lens dose.

    Science.gov (United States)

    Suzuki, S; Furui, S; Ishitake, T; Abe, T; Machida, H; Takei, R; Ibukuro, K; Watanabe, A; Kidouchi, T; Nakano, Y

    2010-05-01

    Some recent studies on radiation lens injuries have indicated much lower dose thresholds than specified by the current radiation protection guidelines. The purpose of this research was to measure the lens dose during brain CT scans with multidetector row CT and to assess methods for estimating the lens dose. With 8 types of multidetector row CT scanners, both axial and helical scans were obtained for the head part of a human-shaped phantom by using normal clinical settings with the orbitomeatal line as the baseline. We measured the doses on both eyelids by using an RPLGD during whole-brain scans including the orbit with the starting point at the level of the inferior orbital rim. To assess the effect of the starting points on the lens doses, we measured the lens doses by using 2 other starting points for scanning (the orbitomeatal line and the superior orbital rim). The CTDIvols and the lens doses during whole-brain CT including the orbit were 50.9-113.3 mGy and 42.6-103.5 mGy, respectively. The ratios of lens dose to CTDIvol were 80.6%-103.4%. The lens doses decreased as the starting points were set more superiorly. The lens doses during scans from the superior orbital rim were 11.8%-20.9% of the doses during the scans from the inferior orbital rim. CTDIvol can be used to estimate the lens dose during whole-brain CT when the orbit is included in the scanning range.

  7. Deep convolutional neural networks as strong gravitational lens detectors

    Science.gov (United States)

    Schaefer, C.; Geiger, M.; Kuntzer, T.; Kneib, J.-P.

    2018-03-01

    realistic lens simulations with more lens-like structures (spiral galaxies or ring galaxies) are needed to compare the performance of deeper and shallower networks.

  8. LENS repair and modification of metal NW components:materials and applications guide.

    Energy Technology Data Exchange (ETDEWEB)

    Smugeresky, John E. (Sandia National Laboratories, Livermore, CA); Gill, David Dennis; Oberhaus, Jason (BWXT Y-12); Adams, Thad (Savannah River National Laboratory); VanCamp, Chad (Kansas City Plant)

    2006-11-01

    welded metal. Tool wear is slightly higher in LENS material than in wrought material, but not so much that one would be concerned with increased tooling cost. The LENS process achieved process qualification for the AY1E0125 D-Bottle Bracket from the W80-3 LEP program, and in the effort, also underwent testing in weapons environments. These tests included structural dynamic response testing and drop testing. The LENS deposited parts were compared in these tests with conventionally machined parts and showed equivalency to such an extent that the parts were accepted for use in parallel path subsystem-level weapon environment testing. The evaluation of LENS has shown that the process can be a viable option when either complete metal parts are needed or existing metal parts require modification or repair. The LENS Qualification Technology Investment team successfully investigated new applications for the LENS process and showed that it has great applicability across the Nuclear Weapons Complex as well as in other high rigor applications.

  9. Sam37 is crucial for formation of the mitochondrial TOM-SAM supercomplex, thereby promoting β-barrel biogenesis.

    Science.gov (United States)

    Wenz, Lena-Sophie; Ellenrieder, Lars; Qiu, Jian; Bohnert, Maria; Zufall, Nicole; van der Laan, Martin; Pfanner, Nikolaus; Wiedemann, Nils; Becker, Thomas

    2015-09-28

    Biogenesis of mitochondrial β-barrel proteins requires two preprotein translocases, the general translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM). TOM and SAM form a supercomplex that promotes transfer of β-barrel precursors. The SAM core complex contains the channel protein Sam50, which cooperates with Sam35 in precursor recognition, and the peripheral membrane protein Sam37. The molecular function of Sam37 has been unknown. We report that Sam37 is crucial for formation of the TOM-SAM supercomplex. Sam37 interacts with the receptor domain of Tom22 on the cytosolic side of the mitochondrial outer membrane and links TOM and SAM complexes. Sam37 thus promotes efficient transfer of β-barrel precursors to the SAM complex. We conclude that Sam37 functions as a coupling factor of the translocase supercomplex of the mitochondrial outer membrane. © 2015 Wenz et al.

  10. Development of Powerhouse Using Fresnel lens

    Directory of Open Access Journals (Sweden)

    Al-Dohani Nawar Saif

    2018-01-01

    Full Text Available Solar energy is an alternative source of renewable energy. Sultanate of Oman government showed initiation on utilization of solar energy for domestic and industrial applications. Fresnel lens is one of the methods to collect maximum energy by gathering heat of the sun in the concentrated form (using solar collectors. Earlier research work discloses that Fresnel lens gave better result in terms of power output and produces lower heat loss as compared to linear –parabolic solar collectors. In this work, development of a proto Fresnel lens power house was made to generate electricity. The focused heat from Fresnel lens was used to heat the molten salt in a heat exchanger to produce the steam. The generated steam was used to rotate the steam engine coupled to a generator. In the current work, a maximum power of 30 W was produced. In addition, comparative study was carried out regarding solar salts and heat exchanger materials to understand the Fresnel powerhouse performance. Overall the present study gave valuable information regarding usage of Fresnel lens for electricity generation in Oman.

  11. Non-compliance in contact lens wear.

    Science.gov (United States)

    Claydon, B E; Efron, N

    1994-10-01

    Non-compliance is emerging as a critical issue in the contact lens field. This problem has been studied at depth in general health care situations and is seen as the responsibility of both practitioner and patient (client) working in a health care partnership. The contact lens practitioner and patient present a specific case for the study of non-compliance in areas such as hygiene, solution use, appointment attendance and wearing times. From 40 to 91% of contact lens patients have been reported as non-complaint in the use of recommended care and maintenance regimens and many of these are confused or ignorant about their behaviour. In order to arrive at a general set of conclusions from the studies published to date, it is important to understand the methodology of each study, it purpose, the definition of non-compliance used and the way the results were analysed and described. This review summarizes the research into non-compliance in the contact lens field to data. A set of general conclusions is drawn and a model for compliance in the context of contact lens practice is proposed.

  12. Spherical aberration in contact lens wear.

    Science.gov (United States)

    Lindskoog Pettersson, A; Jarkö, C; Alvin, A; Unsbo, P; Brautaset, R

    2008-08-01

    The aim of the present studies was to investigate the effect on spherical aberration of different non custom-made contact lenses, both with and without aberration control. A wavefront analyser (Zywave, Bausch & Lomb) was used to measure the aberrations in each subject's right eye uncorrected and with the different contact lenses. The first study evaluated residual spherical aberration with a standard lens (Focus Dailies Disposable, Ciba Vision) and with an aberration controlled contact lens (ACCL) (Definition AC, Optical Connection Inc.). The second study evaluated the residual spherical aberrations with a monthly disposable silicone hydrogel lens with aberration reduction (PureVision, Bausch & Lomb). Uncorrected spherical aberration was positive for all pupil sizes in both studies. In the first study, residual spherical aberration was close to zero with the standard lens for all pupil sizes whereas the ACCL over-corrected spherical aberration. The results of the second study showed that the monthly disposable lens also over-corrected the aberration making it negative. The changes in aberration were statistically significant (plenses. Since the amount of aberration varies individually we suggest that aberrations should be measured with lenses on the eye if the aim is to change spherical aberration in a certain direction.

  13. TESS Lens-Bezel Assembly Modal Testing

    Science.gov (United States)

    Dilworth, Brandon J.; Karlicek, Alexandra

    2017-01-01

    The Transiting Exoplanet Survey Satellite (TESS) program, led by the Kavli Institute for Astrophysics and Space Research at the Massachusetts Institute of Technology (MIT) will be the first-ever spaceborne all-sky transit survey. MIT Lincoln Laboratory is responsible for the cameras, including the lens assemblies, detector assemblies, lens hoods, and camera mounts. TESS is scheduled to be launched in August of 2017 with the primary goal to detect small planets with bright host starts in the solar neighborhood, so that detailed characterizations of the planets and their atmospheres can be performed. The TESS payload consists of four identical cameras and a data handling unit. Each camera consists of a lens assembly with seven optical elements and a detector assembly with four charge-coupled devices (CCDs) including their associated electronics. The optical prescription requires that several of the lenses are in close proximity to a neighboring element. A finite element model (FEM) was developed to estimate the relative deflections between each lens-bezel assembly under launch loads to predict that there are adequate clearances preventing the lenses from making contact. Modal tests using non-contact response measurements were conducted to experimentally estimate the modal parameters of the lens-bezel assembly, and used to validate the initial FEM assumptions. Key Words Non-contact measurements, modal analysis, model validation

  14. The Effects of CO2 Injection and Barrel Temperatures on the Physiochemical and Antioxidant Properties of Extruded Cereals.

    Science.gov (United States)

    Thin, Thazin; Myat, Lin; Ryu, Gi-Hyung

    2016-09-01

    The effects of CO 2 injection and barrel temperatures on the physiochemical and antioxidant properties of extruded cereals (sorghum, barley, oats, and millet) were studied. Extrusion was carried out using a twin-screw extruder at different barrel temperatures (80, 110, and 140°C), CO 2 injection (0 and 500 mL/min), screw speed of 200 rpm, and moisture content of 25%. Extrusion significantly increased the total flavonoid content (TFC) of extruded oats, and β-glucan and protein digestibility (PD) of extruded barley and oats. In contrast, there were significant reductions in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, PD of extruded sorghum and millet, as well as resistant starch (RS) of extruded sorghum and barley, and total phenolic content (TPC) of all extrudates, except extruded millet. At a barrel temperature of 140°C, TPC in extruded barley was significantly increased, and there was also an increase in DPPH and PD in extruded millet with or without CO 2 injection. In contrast, at a barrel temperature of 140°C, the TPC of extruded sorghum decreased, TFC of extruded oats decreased, and at a barrel temperature of 110°C, PD of extruded sorghum without CO 2 decreased. Some physical properties [expansion ratio (ER), specific length, piece density, color, and water absorption index] of the extrudates were significantly affected by the increase in barrel temperature. The CO 2 injection significantly affected some physical properties (ER, specific length, piece density, water solubility index, and water absorption index), TPC, DPPH, β-glucan, and PD. In conclusion, extruded barley and millet had higher potential for making value added cereal-based foods than the other cereals.

  15. Performance and Mechanical Tolerances Achieved with a Full Size Prototype of a CMS Barrel Muon Drift Tubes Chamber

    CERN Document Server

    Bethke, Siegfried; Benettoni, Massimo; Benvenuti, Alberto; Berdugo, Javier; Cerrada, Marcos; Colino, Nicanor; Conti, Enrico; Dallavalle, Gaetano-Marco; Daniel, Manuel; De Giorgi, Marco; De Min, Alberto; Dosselli, Umberto; Fanin, Claudio; Fouz-Iglesias, M C; Gasparini, Fabrizio; Gasparini, Ugo; Giantin, R; Grandi, Claudio; Guaita, Paola; Guerzoni, Marco; Ladrón de Guevara, Pedro; Lippi, Ivano; Marcellini, Stefano; Martinelli, Roberto; Meneguzzo, Anna Teresa; Mocholí-Mocholí, J; Montanari, Alessandro; Montanari, Christian; Navarria, Francesco; Odorici, Fabrizio; Reithler, Hans; Romero, Luciano; Rossi, Antonio; Rovelli, Tiziano; Schwarthoff, Hubert; Sondermann, Volker; Tano, Valeria; Teykal, Helmut; Tutas, Joerg; Van den Hirtz, J; Wagner, H; Wegner, Martin; Willmott, Carlos

    1998-01-01

    The barrel muon chambers of the CMS experiment are made assembling 3 independent modules ( SuperLayers) which together measure the impact point and the angles theta and phi. Each SuperLayer consists of four layers of rectangular Drift Tubes. MB96 is a full size prototype of the smallest CMS Barrel Muon Chamber ( MB1) built in early 1997 at the Legnaro INFN laboratory and tested in summer 1997 at the CERN CMS test beam facility. The performance of the prototype and the mechanical tolerances achieved in the construction are presented.

  16. Acanthamoeba, bacterial, and fungal contamination of contact lens storage cases.

    Science.gov (United States)

    Gray, T B; Cursons, R T; Sherwan, J F; Rose, P R

    1995-01-01

    BACKGROUND--Microbial corneal infection is the most serious complication of contact lens wear. Contact lens cases are a recognised potential source of pathogens associated with corneal ulcers. METHODS--This survey established the incidence of protozoal, bacterial, and fungal contact lens case contamination in 101 asymptomatic daily wear cosmetic contact lens wearers from a domiciliary contact lens practice. RESULTS--Eighty two (81%) contact lens cases were found to be contaminated, with 19 (19%) sterile. Of all contact lens cases, 78 (77%) grew bacteria, 24 (24%) fungi, and 20 (20%) protozoa. Acanthamoeba spp were isolated from eight (8%) contact lens cases. Fifty six (55%) contact lens cases yielded mixed bacterial contamination. This is the first contact lens case survey in which hydrogen peroxide disinfection was the major method of contact lens disinfection (75% of subjects) and no home made saline was used. All the contaminating organisms were shown to possess the enzyme catalase that breaks down hydrogen peroxide to oxygen and water. The polymicrobial nature of the biofilms found in many contact lens cases is illustrated electron micrographically. CONCLUSION--Based on data from this and previous studies, the authors conclude with recommendations for contact lens wearers: (1) regular scrubbing of contact lens case interior to disrupt biofilms; (2) exposure of contact lens case to very hot water (> or = 70 degrees C) will kill Acanthamoeba contaminants; (3) allow contact lens case to air dry between uses; (4) if hydrogen peroxide disinfection is preferred, use a two step system; (5) replace contact lens case regularly. Images PMID:7626578

  17. Characterization of lens based photoacoustic imaging system

    Directory of Open Access Journals (Sweden)

    Kalloor Joseph Francis

    2017-12-01

    Full Text Available Some of the challenges in translating photoacoustic (PA imaging to clinical applications includes limited view of the target tissue, low signal to noise ratio and the high cost of developing real-time systems. Acoustic lens based PA imaging systems, also known as PA cameras are a potential alternative to conventional imaging systems in these scenarios. The 3D focusing action of lens enables real-time C-scan imaging with a 2D transducer array. In this paper, we model the underlying physics in a PA camera in the mathematical framework of an imaging system and derive a closed form expression for the point spread function (PSF. Experimental verification follows including the details on how to design and fabricate the lens inexpensively. The system PSF is evaluated over a 3D volume that can be imaged by this PA camera. Its utility is demonstrated by imaging phantom and an ex vivo human prostate tissue sample.

  18. Freeform micromachining of an infrared Alvarez lens

    Science.gov (United States)

    Smilie, Paul J.; Dutterer, Brian S.; Lineberger, Jennifer L.; Davies, Matthew A.; Suleski, Thomas J.

    2011-02-01

    In 1967, Luis Alvarez introduced a novel concept for a focusing lens whereby two transmitting elements with cubic polynomial surfaces yield a composite lens of variable focal length with small lateral shifts. Computer simulations have demonstrated the behavior of these devices, but fabricating the refractive cubic surfaces of the types needed with adequate precision and depth modulation has proven to be challenging using standard methods, and, to the authors' knowledge, Alvarez lens elements have not been previously machined in infrared materials. Recent developments in freeform diamond machining capability have enabled the fabrication of such devices. In this paper, we discuss the fabrication of freeform refractive Alvarez elements in germanium using diamond micro-milling on a five-axis Moore Nanotech® 350FG Freeform Generator. Machining approaches are discussed, and measurements of surface figure and finish are presented. Initial experimental tests of optical performance are also discussed.

  19. Invited review article: the electrostatic plasma lens.

    Science.gov (United States)

    Goncharov, Alexey

    2013-02-01

    The fundamental principles, experimental results, and potential applications of the electrostatic plasma lens for focusing and manipulating high-current, energetic, heavy ion beams are reviewed. First described almost 50 years ago, this optical beam device provides space charge neutralization of the ion beam within the lens volume, and thus provides an effective and unique tool for focusing high current beams where a high degree of neutralization is essential to prevent beam blow-up. Short and long lenses have been explored, and a lens in which the magnetic field is provided by rare-earth permanent magnets has been demonstrated. Applications include the use of this kind of optical tool for laboratory ion beam manipulation, high dose ion implantation, heavy ion accelerator injection, in heavy ion fusion, and other high technology.

  20. 3D printed helical antenna with lens

    KAUST Repository

    Farooqui, Muhammad Fahad

    2016-12-19

    The gain of an antenna can be enhanced through the integration of a lens, however this technique has traditionally been restricted to planar antennas due to fabrication limitations of standard manufacturing processes. Here, with a unique combination of 3D and 2D inkjet printing of dielectric and metallic inks respectively, we demonstrate a Fresnel lens that has been monolithically integrated to a non-planar antenna (helix) for the first time. Antenna measurements show that the integration of a Fresnel lens enhances the gain of a 2-turn helix by around 4.6 dB giving a peak gain of about 12.9 dBi at 8.8 GHz.

  1. An "ESA-affordable" Laue-lens

    DEFF Research Database (Denmark)

    Lund, Niels

    2005-01-01

    With ESA's INTEGRAL mission gamma-ray astronomy has advanced to the point where major scientific advances must be expected from detailed studies of the many new point sources. The interest in developing focusing telescopes operating in the soft gamma-ray regime up to 1 MeV is therefore mounting r...... constraints of a specific medium size launch vehicle. The introduction of the lens mass as a primary design driver has some surprising effects for the choice of material for the crystals and new tradeoff considerations are introduced....... rapidly. Telescopes based on Laue diffraction of gamma-rays from crystals appear as one promising route, although the practical difficulties of realizing a large scale Laue lens are certainly not small. In this paper I have attempted to develop an optimized lens design considering the size and mass...

  2. Modeling of a Variable Focal Length Flat Lens Using Left Handed Metamaterials

    Science.gov (United States)

    Reinert, Jason

    2004-01-01

    Left Handed Metamaterials (LHM) were originally purposed by Victor Veselago in1968. These substances would allow a flat structure to focus electromagnetic (EM) waves because they have a negative index of refraction. A similar structure made from conventional materials, those with a positive index of refraction, would disperse the waves. But until recently, these structures have been purely theoretical because substances with both a negative permittivity and negative permeability, material properties necessary for a negative index of refraction, do not naturally exist, Recent developments have produced a structure composed of an array of thin wires and split ring resonators that shows a negative index of refraction. area smaller than a square wavelength. How small the area is can be determined by how perfectly the lens is polished and how pure the substance is that composes the lens. These lenses must also be curved for focusing to occur. The focal length is determined by the curvature of the lens and the material. On the other hand, a flat structure made from LHM would focus light because of the effect of a negative index of refraction in Snell s law. The focal length could also be varied by simply adjusting the distance of the lens from the source of radiation. This could create many devices that are adjustable to different situations in fields such as biomedical imaging and communication. the software package XFDTD which solves Maxwell s equations in the frequency domain as well as the time domain. The program used Drude models of materials to simulate the effect of negative permittivity and negative permeability. Because of this, a LHM can be simulated as a solid block of material instead of an array of wires and split ring resonators. After a flat lens is formed, I am to examine the focusing effect of the lens and determine if a higher resolution flat lens can be developed. Traditional lenses made from conventional materials cannot focus an EM wave onto an My

  3. The effectiveness of soft contact lens disinfection systems against Acanthamoeba on the lens surface.

    Science.gov (United States)

    Liedel, K K; Begley, C G

    1996-03-01

    This investigation compared the efficacy of three widely used contact lens disinfection systems against an ocular isolate of Acanthamoeba polyphaga. Twenty-seven worn Ciba NewVues lenses were quartered, heat sterilized and inoculated with Acanthamoeba. Lens quarters were then randomly assigned to three experimental groups, with Group A lenses exposed to cleaner and saline rinse only, Group B to disinfection only, and Group C to both cleaner and disinfection. One quarter of each lens served as a control and the other three quarters were experimental. Quantification of viable Acanthamoeba remaining on the lens was performed after each step of the disinfection process. Group A lenses showed no significant difference between the treatments, or the treatments and the control. Group B lenses demonstrated a significant difference (p = 0.0001) between the treatments and the control. In Group C (cleaning and disinfection), the control lens quarters were significantly different (p = 0.037) from the experimental group, but there was no significant difference between the treatments. All three disinfection regimens were very effective in reducing the number of viable Acanthamoeba on the contact lens surface. In the absence of proper cleaning (Group B), AOSept was the most effective of the three. These results also show the importance of thoroughly rubbing the contact lens surface to decrease the number of Acanthamoeba.

  4. Non-compliance with lens care and maintenance in diabetic contact lens wearers.

    Science.gov (United States)

    O'Donnell, Clare; Efron, Nathan

    2004-11-01

    We hypothesize that diabetic contact lens wearers may represent a special group displaying higher levels of compliance with their lens care regimens as a result of learned behaviour relating to maintenance of their diabetic condition. To test this hypothesis, a prospective, single centre, controlled, masked study was performed whereby 29 diabetic contact lens patients and 29 non-diabetic control subjects were issued with disposable hydrogel contact lenses and a multipurpose lens care regimen. All participants were given identical instruction on lens care and maintenance. Compliance levels were assessed at a 12-month aftercare appointment by demonstration and questionnaire. Twenty-four different aspects of compliance were scored, 12 by observation and 12 by questionnaire report, of which only two showed a significant difference between the diabetic and control groups. Although the combined population of contact lens wearers was generally compliant, there were examples of non-compliance in both groups. Neither the duration of diabetes nor the degree of metabolic control appeared to have a significant effect on compliance. The results suggest that eye care practitioners cannot assume that diabetic patients will be more compliant with contact lens care and maintenance than non-diabetic patients.

  5. Analytic models of plausible gravitational lens potentials

    International Nuclear Information System (INIS)

    Baltz, Edward A.; Marshall, Phil; Oguri, Masamune

    2009-01-01

    Gravitational lenses on galaxy scales are plausibly modelled as having ellipsoidal symmetry and a universal dark matter density profile, with a Sérsic profile to describe the distribution of baryonic matter. Predicting all lensing effects requires knowledge of the total lens potential: in this work we give analytic forms for that of the above hybrid model. Emphasising that complex lens potentials can be constructed from simpler components in linear combination, we provide a recipe for attaining elliptical symmetry in either projected mass or lens potential. We also provide analytic formulae for the lens potentials of Sérsic profiles for integer and half-integer index. We then present formulae describing the gravitational lensing effects due to smoothly-truncated universal density profiles in cold dark matter model. For our isolated haloes the density profile falls off as radius to the minus fifth or seventh power beyond the tidal radius, functional forms that allow all orders of lens potential derivatives to be calculated analytically, while ensuring a non-divergent total mass. We show how the observables predicted by this profile differ from that of the original infinite-mass NFW profile. Expressions for the gravitational flexion are highlighted. We show how decreasing the tidal radius allows stripped haloes to be modelled, providing a framework for a fuller investigation of dark matter substructure in galaxies and clusters. Finally we remark on the need for finite mass halo profiles when doing cosmological ray-tracing simulations, and the need for readily-calculable higher order derivatives of the lens potential when studying catastrophes in strong lenses

  6. The corneal stroma during contact lens wear.

    Science.gov (United States)

    Jalbert, Isabelle; Stapleton, Fiona

    2005-03-01

    Recent technological advances have lead to novel descriptions of the microanatomy of the corneal stroma. In the first section of this review, these findings and the role they play in the maintenance of vital properties such as corneal transparency, mechanical strength, homeostasis, wound-healing response and metabolism are described. In the second part, contact lens induced stromal alterations such as acidosis, oedema, striae, thinning and opacities are reviewed as well as the more recently described phenomenon of microdot deposits and keratocyte loss with an emphasis on how lens wearing stromal effects can be minimised.

  7. Sterilization potential of contact lens solutions

    Directory of Open Access Journals (Sweden)

    Dada Vijay

    1988-01-01

    Full Text Available In a dynamic field of Contact Lens Solutions maintenance of high standards of anti-microbial activity is a must Resterilization Activity Time′ is a universally accepted yardstick for such an evaluation. In this study eight brands of indigenous popular solutions alongwith two FDA approved solutions were tested for their sterilization efficacy: Standardized suspensions of Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Aspergillus fumigatus were used for the purpose. It was observed that the contact lens solutions available ir, the domestic market were not upto the mark Suggestions for improvement have also been made.

  8. Rotman lens for mm-wavelengths

    Science.gov (United States)

    Hall, Leonard T.; Hansen, Hedley J.; Abbott, Derek

    2002-11-01

    The 77 GHz band has been reserved for intelligent cruise control in luxury cars and some public transport services in America and the United Kingdom. The Rotman lens offers a cheap and compact means to extend the single beam systems generally used, to fully functional beam staring arrangements. Rotman lenses have been built for microwave frequencies with limited success. The flexibility of microstrip transmission lines and the advent of fast accurate simulation packages allow practical Rotman lenses to be designed at mm-wavelengths. This paper discusses the limitations of the conventional design approach and predicts the performance of a new Rotman lens designed at 77 GHz.

  9. Pulse transformer for the AA lithium lens

    CERN Document Server

    CERN PhotoLab

    1980-01-01

    The antiprotons emanating from the target were initially focused by a magnetic horn. Later on, a Li-lens was used during operation for the SPS collider, until 1992. A Li-rod (130 mm long, 34 mm in diameter) constituted the secondary of a 1:23 pulse-transformer. The half-sine pulse rose to 1000 kA in 900 microsec. The angular acceptance was 95 mrad. In operation after 1992, for LEAR only, a more modest Li-lens was used (155 mm long, diameter 20 mm, 480 kA, risetime 240 microsec, angular acceptance 75 mrad).

  10. Laminar-specific encoding of texture elements in rat barrel cortex.

    Science.gov (United States)

    Allitt, Benjamin J; Alwis, Dasuni S; Rajan, Ramesh

    2017-12-01

    For rats texture discrimination is signalled by the large face whiskers by stick-slip events. Neural encoding of repetitive stick-slip events will be influenced by intrinsic properties of adaptation. We show that texture coding in the barrel cortex is laminar specific and follows a power function. Our results also show layer 2 codes for novel feature elements via robust firing rates and temporal fidelity. We conclude that texture coding relies on a subtle neural ensemble to provide important object information. Texture discrimination by rats is exquisitely guided by fine-grain mechanical stick-slip motions of the face whiskers as they encounter, stick to and slip past successive texture-defining surface features such as bumps and grooves. Neural encoding of successive stick-slip texture events will be shaped by adaptation, common to all sensory systems, whereby receptor and neural responses to a stimulus are affected by responses to preceding stimuli, allowing resetting to signal novel information. Additionally, when a whisker is actively moved to contact and brush over surfaces, that motion itself generates neural responses that could cause adaptation of responses to subsequent stick-slip events. Nothing is known about encoding in the rat whisker system of stick-slip events defining textures of different grain or the influence of adaptation from whisker protraction or successive texture-defining stick-slip events. Here we recorded responses from halothane-anaesthetized rats in response to texture-defining stimuli applied to passive whiskers. We demonstrate that: across the columnar network of the whisker-recipient barrel cortex, adaptation in response to repetitive stick-slip events is strongest in uppermost layers and equally lower thereafter; neither whisker protraction speed nor stick-slip frequency impede encoding of stick-slip events at rates up to 34.08 Hz; and layer 2 normalizes responses to whisker protraction to resist effects on texture signalling. Thus

  11. Immunochemical analyses of soluble lens proteins in some marine fishes

    Digital Repository Service at National Institute of Oceanography (India)

    Menezes, M.R.

    Soluble eye lens proteins of 10 fishes, belonging to the families Clupeidae, Hemirhamphidae, Lactaridae, Scombridae, Stromatidae, Psettodidae, Bothidae and Soleidae were studied by immunoelectrophoresis using the lens antiserum of Sardinella...

  12. IOL Implants: Lens Replacement and Cataract Surgery (Intraocular Lenses)

    Science.gov (United States)

    ... Cataract Surgery vs. Laser-Assisted Cataract Surgery Cataract Vision Simulator Cataract Pictures and Videos: What Do ... Mar. 27, 2018 An intraocular lens (or IOL) is a tiny, artificial lens for the eye. It replaces the eye's ...

  13. Compositional Dependence Of Hardness Of Ge-Sb-Se Glass For Molded Lens Applications

    Directory of Open Access Journals (Sweden)

    Park J.K.

    2015-06-01

    Full Text Available Chalcogenide glass in the ternary Ge-Sb-Se system is inherently moldable, thus being considered as a strong candidate material for use in infrared-transmitting lens applications from the viewpoint of thermal and mechanical stability. In an effort to experimentally determine compositional region suitable for the molded lens applications, we evaluate its compositional dependence of hardness. Among the constituent atoms, Ge content turns out to exert a most conspicuous correlation with hardness. This phenomenological behavior is then explained in connection with the structural evolution that Ge brings about.

  14. Component and prototype panel testing of the mini-dome Fresnel lens photovoltaic concentrator array

    Science.gov (United States)

    Piszczor, Michael F.; Swartz, Clifford K.; O'Neill, Mark J.

    1990-01-01

    The mini-dome Fresnel lens concentrator array, a high-efficiency, lightweight space photovoltaic array concept, is described. The three critical elements of the array concept are the Fresnel lens concentrator, the prismatic cell power cover, and the photovoltaic cell. Prototype concentrator lenses have been fabricated and tested, with optical efficiencies reaching 90 percent. Work is progressing on the design and fabrication of the panel structure. The impact of recent advances in 30 percent-efficient multijunction photovoltaic cells on array performance is also discussed. Near-term performance goals of 300 w/sq m and 100 w/kg are now feasible.

  15. Correlations between refractive error and biometric parameters in human eyes using the LenStar 900.

    Science.gov (United States)

    O'Donnell, Clare; Hartwig, Andreas; Radhakrishnan, Hema

    2011-02-01

    To investigate the relationship between refractive error and ocular biometry in healthy subjects using a new optical low coherence reflectometry device. Biometric measurements were obtained with a LenStar LS 900 (Haag Streit, Switzerland) on one eye of 70 phakic subjects (mean ± SD age; 29 ± 9 years). Forty myopes and 30 non-myopes (best sphere range -9.63 D to +0.63 D) were included. Outcome measures were compared for the two groups using one way between groups ANOVA. These included; keratometry, central corneal thickness, iris width, anterior chamber depth, pupil diameter, lens thickness, axial length and retinal thickness. No mydriatic or cycloplegic agents were used. There were significant differences between groups for keratometry readings (p = 0.021 and p = 0.038 for steep and flat k readings respectively), anterior chamber depth (p = 0.001), lens thickness (p = 0.026) and axial length (pbiometric parameters assessed and provides information about the relationships between these biometric parameters and age. The results, coupled with a unique ability to image and analyse the ocular structures non-invasively make the LenStar a promising new instrument for ocular evaluation in research and clinical practice. Copyright © 2010 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

  16. Workplace Educators' Interpretations of Their Assessment Practices: A View through a Critical Practice Lens

    Science.gov (United States)

    Trede, Franziska; Smith, Megan

    2014-01-01

    In this paper, we examine workplace educators' interpretations of their assessment practices. We draw on a critical practice lens to conceptualise assessment practice as a social, relational and situated practice that becomes critical through critique and emancipation. We conducted semi-structured interviews followed by roundtable discussions with…

  17. Lens autofluorescence is not increased at high altitude

    DEFF Research Database (Denmark)

    Kessel, Line; Kofoed, Peter Kristian; Zubieta-Calleja, Gustavo

    2010-01-01

    PURPOSE: To study the relation between ambient environmental ultraviolet radiation exposure and lens fluorescence. METHODS: Non-invasive lens fluorometry measurements were compared in healthy Bolivian and Danish subjects. Background ultraviolet radiation was 4.5 times higher in Bolivia than in De...... living at sea level at 55 degrees northern latitude. These results suggest that lens ageing, as assessed by lens autofluorometry, is independent of exposure to ultraviolet radiation....

  18. TMB-Hunt: An amino acid composition based method to screen proteomes for beta-barrel transmembrane proteins

    Directory of Open Access Journals (Sweden)

    Agnew Alison

    2005-03-01

    Full Text Available Abstract Background Beta-barrel transmembrane (bbtm proteins are a functionally important and diverse group of proteins expressed in the outer membranes of bacteria (both gram negative and acid fast gram positive, mitochondria and chloroplasts. Despite recent publications describing reasonable levels of accuracy for discriminating between bbtm proteins and other proteins, screening of entire genomes remains troublesome as these molecules only constitute a small fraction of the sequences screened. Therefore, novel methods are still required capable of detecting new families of bbtm protein in diverse genomes. Results We present TMB-Hunt, a program that uses a k-Nearest Neighbour (k-NN algorithm to discriminate between bbtm and non-bbtm proteins on the basis of their amino acid composition. By including differentially weighted amino acids, evolutionary information and by calibrating the scoring, an accuracy of 92.5% was achieved, with 91% sensitivity and 93.8% positive predictive value (PPV, using a rigorous cross-validation procedure. A major advantage of this approach is that because it does not rely on beta-strand detection, it does not require resolved structures and thus larger, more representative, training sets could be used. It is therefore believed that this approach will be invaluable in complementing other, physicochemical and homology based methods. This was demonstrated by the correct reassignment of a number of proteins which other predictors failed to classify. We have used the algorithm to screen several genomes and have discussed our findings. Conclusion TMB-Hunt achieves a prediction accuracy level better than other approaches published to date. Results were significantly enhanced by use of evolutionary information and a system for calibrating k-NN scoring. Because the program uses a distinct approach to that of other discriminators and thus suffers different liabilities, we believe it will make a significant contribution to the

  19. Surface modification of fluorosilicone acrylate RGP contact lens via low-temperature argon plasma

    International Nuclear Information System (INIS)

    Yin Shiheng; Wang Yingjun; Ren Li; Zhao Lianna; Kuang Tongchun; Chen Hao; Qu Jia

    2008-01-01

    A fluorosilicone acrylate rigid gas permeable (RGP) contact lens was modified via argon plasma to improve surface hydrophilicity and resistance to protein deposition. The influence of plasma treatment on surface chemical structure, hydrophilicity and morphology of RGP lens was investigated by X-ray photoelectron spectrometer (XPS), contact angle measurements and scanning electron microscope (SEM), respectively. The contact angle results showed that the hydrophilicity of the contact lens was improved after plasma treatment. XPS results indicated that the incorporation of oxygen-containing groups on surface and the transformation of silicone into hydrophilic silicate after plasma treatment are the main reasons for the surface hydrophilicity improvement. SEM results showed that argon plasma with higher power could lead to surface etching

  20. A mutant with bilateral whisker to barrel inputs unveils somatosensory mapping rules in the cerebral cortex.

    Science.gov (United States)

    Renier, Nicolas; Dominici, Chloé; Erzurumlu, Reha S; Kratochwil, Claudius F; Rijli, Filippo M; Gaspar, Patricia; Chédotal, Alain

    2017-03-28

    In mammals, tactile information is mapped topographically onto the contralateral side of the brain in the primary somatosensory cortex (S1). In this study, we describe Robo3 mouse mutants in which a sizeable fraction of the trigemino-thalamic inputs project ipsilaterally rather than contralaterally. The resulting mixture of crossed and uncrossed sensory inputs creates bilateral whisker maps in the thalamus and cortex. Surprisingly, these maps are segregated resulting in duplication of whisker representations and doubling of the number of barrels without changes in the size of S1. Sensory deprivation shows competitive interactions between the ipsi/contralateral whisker maps. This study reveals that the somatosensory system can form a somatotopic map to integrate bilateral sensory inputs, but organizes the maps in a different way from that in the visual or auditory systems. Therefore, while molecular pre-patterning constrains their orientation and position, preservation of the continuity of inputs defines the layout of the somatosensory maps.