On the Elastic Vibration Model for High Length-Diameter Ratio Rocket with Attitude Control System
朱伯立; 杨树兴
2003-01-01
An elastic vibration model for high length-diameter ratio spinning rocket with attitude control system which can be used for trajectory simulation is established. The basic theory of elastic dynamics and vibration dynamics were both used to set up the elastic vibration model of rocket body. In order to study the problem more conveniently, the rocket's body was simplified to be an even beam with two free ends. The model was validated by simulation results and the test data.
Mechanical model of the recovery reaction from stumbling: effect of step length on trunk control
Forner-Cordero, A.; Koopman, H.F.J.M.; Helm, van der F.C.T.
2014-01-01
Falling after a gait perturbation is a major problem for elderly people. The goal of this paper is to model some mechanical limitations of the recovery strategies performed after a trip or stumble, such as elevating or lowering strategies. A biomechanical model of the recovery was used to interpret
Dither Cavity Length Controller with Iodine Locking
Lawson Marty
2016-01-01
Full Text Available A cavity length controller for a seeded Q-switched frequency doubled Nd:YAG laser is constructed. The cavity length controller uses a piezo-mirror dither voltage to find the optimum length for the seeded cavity. The piezo-mirror dither also dithers the optical frequency of the output pulse. [1]. This dither in optical frequency is then used to lock to an Iodine absorption line.
Controlling the s-wave scattering length with non-resonant light: Predictions of an asymptotic model
Crubellier, Anne; Koch, Christiane P; Luc-Koenig, Eliane
2016-01-01
A pair of atoms interacts with non-resonant light via its anisotropic polarizability. This effect can be used to tune the scattering properties of the atoms. Although the light-atom interaction varies with interatomic separation as $1/R^{3}$, the effective s-wave potential decreases more rapidly, as $1/R^{4}$ such that the field-dressed scattering length can be determined without any formal difficulty. The scattering dynamics are essentially governed by the long-range part of the interatomic interaction and can thus be accurately described by an asymptotic model [Crubellier et al., New J. Phys. 17, 045020 (2015)]. Here we use the asymptotic model to determine the field-dressed scattering length from the s-wave radial component of a particular threshold wave function. Applying our theory to the scattering of two strontium isotopes, we calculate the variation of the scattering length with the intensity of the non-resonant light. Moreover, we predict the intensities at which the scattering length becomes infinit...
Polyketide chain length control by chain length factor.
Tang, Yi; Tsai, Shiou-Chuan; Khosla, Chaitan
2003-10-22
Bacterial aromatic polyketides are pharmacologically important natural products. A critical parameter that dictates product structure is the carbon chain length of the polyketide backbone. Systematic manipulation of polyketide chain length represents a major unmet challenge in natural product biosynthesis. Polyketide chain elongation is catalyzed by a heterodimeric ketosynthase. In contrast to homodimeric ketosynthases found in fatty acid synthases, the active site cysteine is absent from the one subunit of this heterodimer. The precise role of this catalytically silent subunit has been debated over the past decade. We demonstrate here that this subunit is the primary determinant of polyketide chain length, thereby validating its designation as chain length factor. Using structure-based mutagenesis, we identified key residues in the chain length factor that could be manipulated to convert an octaketide synthase into a decaketide synthase and vice versa. These results should lead to novel strategies for the engineered biosynthesis of hitherto unidentified polyketide scaffolds.
Cellular Mechanisms of Ciliary Length Control
Jacob Keeling
2016-01-01
Full Text Available Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development, cell mobility, and tissue homeostasis. Defects in ciliary structure or function are associated with multiple human disorders called ciliopathies. These diseases affect diverse tissues, including, but not limited to the eyes, kidneys, brain, and lungs. Many processes must be coordinated simultaneously in order to initiate ciliogenesis. These include cell cycle, vesicular trafficking, and axonemal extension. Centrioles play a central role in both cell cycle progression and ciliogenesis, making the transition between basal bodies and mitotic spindle organizers integral to both processes. The maturation of centrioles involves a functional shift from cell division toward cilium nucleation which takes place concurrently with its migration and fusion to the plasma membrane. Several proteinaceous structures of the distal appendages in mother centrioles are required for this docking process. Ciliary assembly and maintenance requires a precise balance between two indispensable processes; so called assembly and disassembly. The interplay between them determines the length of the resulting cilia. These processes require a highly conserved transport system to provide the necessary substances at the tips of the cilia and to recycle ciliary turnover products to the base using a based microtubule intraflagellar transport (IFT system. In this review; we discuss the stages of ciliogenesis as well as mechanisms controlling the lengths of assembled cilia.
Monteiro, Felipe R.
2016-01-01
The extensive use of digital controllers demands a growing effort to prevent design errors that appear due to finite-word length (FWL) effects. However, there is still a gap, regarding verification tools and methodologies to check implementation aspects of control systems. Thus, the present paper describes an approach, which employs bounded model checking (BMC) techniques, to verify fixed-point digital controllers represented by state-space equations. The experimental results demonstrate the ...
Delayed feedback model of axonal length sensing.
Karamched, Bhargav R; Bressloff, Paul C
2015-05-05
A fundamental question in cell biology is how the sizes of cells and organelles are regulated at various stages of development. Size homeostasis is particularly challenging for neurons, whose axons can extend from hundreds of microns to meters (in humans). Recently, a molecular-motor-based mechanism for axonal length sensing has been proposed, in which axonal length is encoded by the frequency of an oscillating retrograde signal. In this article, we develop a mathematical model of this length-sensing mechanism in which advection-diffusion equations for bidirectional motor transport are coupled to a chemical signaling network. We show that chemical oscillations emerge due to delayed negative feedback via a Hopf bifurcation, resulting in a frequency that is a monotonically decreasing function of axonal length. Knockdown of either kinesin or dynein causes an increase in the oscillation frequency, suggesting that the length-sensing mechanism would produce longer axons, which is consistent with experimental findings. One major prediction of the model is that fluctuations in the transport of molecular motors lead to a reduction in the reliability of the frequency-encoding mechanism for long axons. Copyright © 2015 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Minimum Description Length Shape and Appearance Models
Thodberg, Hans Henrik
2003-01-01
The Minimum Description Length (MDL) approach to shape modelling is reviewed. It solves the point correspondence problem of selecting points on shapes defined as curves so that the points correspond across a data set. An efficient numerical implementation is presented and made available as open s...... source Matlab code. The problems with the early MDL approaches are discussed. Finally the MDL approach is extended to an MDL Appearance Model, which is proposed as a means to perform unsupervised image segmentation....
Filament-length-controlled elasticity in 3D fiber networks.
Broedersz, C P; Sheinman, M; Mackintosh, F C
2012-02-17
We present a model for disordered 3D fiber networks to study their linear and nonlinear elasticity. In contrast to previous 2D models, these 3D networks with binary crosslinks are underconstrained with respect to fiber stretching elasticity, suggesting that bending may dominate their response. We find that such networks exhibit a bending-dominated elastic regime controlled by fiber length, as well as a crossover to a stretch-dominated regime for long fibers. Finally, by extending the model to the nonlinear regime, we show that these networks become intrinsically nonlinear with a vanishing linear response regime in the limit of flexible or long filaments.
Cycle length maximization in PWRs using empirical core models
Okafor, K.C.; Aldemir, T.
1987-01-01
The problem of maximizing cycle length in nuclear reactors through optimal fuel and poison management has been addressed by many investigators. An often-used neutronic modeling technique is to find correlations between the state and control variables to describe the response of the core to changes in the control variables. In this study, a set of linear correlations, generated by two-dimensional diffusion-depletion calculations, is used to find the enrichment distribution that maximizes cycle length for the initial core of a pressurized water reactor (PWR). These correlations (a) incorporate the effect of composition changes in all the control zones on a given fuel assembly and (b) are valid for a given range of control variables. The advantage of using such correlations is that the cycle length maximization problem can be reduced to a linear programming problem.
Oppel, M.; Paramonov, G. K.
1998-06-01
Selective excitation of the vibrational bound and the continuum states, controlled by subpicosecond infrared (IR) laser pulses, is simulated within the Schrödinger wave function formalism for a two-dimensional model of the HONO 2 molecule in the ground electronic state. State-selective excitation of the OH bond is achieved by single optimal laser pulses, with the probability being 97% for the bound states and more than 91% for the resonances. Stable, long-living continuum states are prepared with more than 96% probability by two optimal laser pulses, with the expectation energy of the molecule being well above the dissociation threshold of the ON single bond, and its life-time being at least 100 ps. The length of the ON single bond can be controlled selectively: stretching and contraction by about 45% of its equilibrium length are demonstrated. Laser separation of spatial conformers of HONO 2 in inhomogeneous conditions occurring on an anisotropic surface or created by a direct current (DC) electric field is analysed. The relative yields of target conformers may be very high, ranging from 10 to 10 8, and the absolute yields of up to 40% and more are calculated.
Antenna mechanism of length control of actin cables
Mohapatra, Lishibanya; Kondev, Jane
2014-01-01
Actin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells. In a yeast cell undergoing budding, cables are in constant dynamic turnover yet some cables grow from the bud neck toward the back of the mother cell until their length roughly equals the diameter of the mother cell. This raises the question: how is the length of these cables controlled? Here we describe a novel molecular mechanism for cable length control inspired by recent experimental observations in cells. This antenna mechanism involves three key proteins: formins, which polymerize actin, Smy1 proteins, which bind formins and inhibit actin polymerization, and myosin motors, which deliver Smy1 to formins, leading to a length-dependent actin polymerization rate. We compute the probability distribution of cable lengths as a function of several experimentally tuneable parameters such as the formin-binding affinity of Smy1 and the concentra...
Feedback Linearization Based Arc Length Control for Gas Metal Arc Welding
Thomsen, Jesper Sandberg
2005-01-01
In this paper a feedback linearization based arc length controller for gas metal arc welding (GMAW) is described. A nonlinear model describing the dynamic arc length is transformed into a system where nonlinearities can be cancelled by a nonlinear state feedback control part, and thus, leaving only...
Traffic jam at adjustable tollgates controlled by line length
Nagatani, Takashi
2016-01-01
We present the stochastic model for the jam formation at the tollgates of which the number is adjusted by synchronizing with the jam's length. We study the jam formation and its fluctuation in front of the adjustable tollgates on a highway. Controlling the number of tollgates has an important effect on the jam formation. The jams are classified into three kinds: (a) localized jam, (b) synchronized jam, and (c) growing jam. The jamming transitions from the localized jam, through the synchronized jam, to the growing jam occur with increasing inflow probability. At an intermediate inflow, the jam fluctuates largely by synchronizing with the number of tollgates. When the inflow probability is higher than the sum of outflow probabilities at tollgates, the jam continues to grow and diverge with time. The dependence of the fluctuating jam on the inflow probability is clarified.
Antenna Mechanism of Length Control of Actin Cables.
Lishibanya Mohapatra
2015-06-01
Full Text Available Actin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells. In a yeast cell undergoing budding, cables are in constant dynamic turnover yet some cables grow from the bud neck toward the back of the mother cell until their length roughly equals the diameter of the mother cell. This raises the question: how is the length of these cables controlled? Here we describe a novel molecular mechanism for cable length control inspired by recent experimental observations in cells. This "antenna mechanism" involves three key proteins: formins, which polymerize actin, Smy1 proteins, which bind formins and inhibit actin polymerization, and myosin motors, which deliver Smy1 to formins, leading to a length-dependent actin polymerization rate. We compute the probability distribution of cable lengths as a function of several experimentally tuneable parameters such as the formin-binding affinity of Smy1 and the concentration of myosin motors delivering Smy1. These results provide testable predictions of the antenna mechanism of actin-cable length control.
Test Bed For Control Of Optical-Path Lengths
O'Neal, Michael C.; Eldred, Daniel D.; Liu, Dankai; Redding, David C.
1994-01-01
Truss structure and ancillary equipment constitute test bed for experiments in methods of controlling lengths of optical paths under conditions of structural vibration and deformation. Accommodates both passive and active methods of control. Experimental control system reduces millimeter-level disturbances in optical path length to nanometers. Developed for control, alignment, and aiming of distributed optical systems on large flexible structures. Test bed includes tower 2.5 meters high with two horizontal arms extending at right angles from its top. Rigidly mounted on massive steel block providing measure of isolation from ground vibrations. Optical motion-compensation system similar to one described previously in NASA Tech Briefs enclosed in flexure-mounted frame, called "trolley," at end of longer horizontal arm.
Gestation length in red deer: genetically determined or environmentally controlled?
Asher, G W
2007-01-01
The red deer (Cervus elaphus) of European origin (e.g. subspecies scoticus, hispanicus, hippelaphus) is a medium sized (100-150kg mature hind weight) ruminant that exhibits highly seasonally patterns of autumn conceptions and summer births. Historic data indicate average (+/- s.d.) gestation length of 233-234 (+/- 2-4) days. Recently, however, there has been growing awareness that there is considerably greater variation in gestation length than earlier indicated and that there is a significant element of environmental, and possibly even social, control over the duration of pregnancy in this species. Imposition of variable levels of nutrition over late pregnancy of red deer hinds has been observed to influence fetal growth trajectory and gestation length, with no apparent effect on birth weight. This supports a hypothesis that under conditions of modest feed imbalance, variation in gestation length compensates for variation in fetal growth trajectory to ensure optimisation of birth weight. More recent studies on primiparous (24 month old) red deer hinds have identified surprisingly large variation in gestation length (193-263 days) compared with adult hinds (228-243 days), with earlier conceiving individuals within the primiparous cohort expressing significantly longer gestation than the later conceiving hinds, resulting in a higher level of calving synchrony than expected from known conception dates. This introduces an intriguing hypothesis of social indicative effects on parturition timing to promote within-cohort birth synchrony. Collectively, these data debunk the commonly held notion that gestation length of red deer is genetically fixed within strict limits. A review of the literature points to this as possibly a common phenomenon across a range of non-domesticated ruminant species but this conclusion is not supported by numerous conflicting studies on domestic sheep and cattle.
Control of vocal-tract length in speech
Riordan, C.J.
1977-10-01
Essential for the correct production of vowels is the accurate control of vocal-tract length. Perkell (Psychology of Speech Production (MIT, Cambridge, MA, 1969)) has suggested that two important determinants of vocal-tract length are vertical larynx position and lip spreading/protrusion, often acting together. The present study was designed to determine whether constraining lip spreading/protrusion induces compensatory vertical larynx displacements, particularly on rounded vowels. Upper lip and larynx movement were monitored photoelectrically while French and Mandarin native speakers produced the vowels /i,y,u/ first under normal-speech conditions and then with lip activity constrained. Significant differences were found in upper-lip protrusion and larynx position depending on the vowel uttered. Moreover, the generally low-larynx position of rounded vowels became even lower when lip protrusion was constrained. These results imply that compensatory articulations contribute to a contrast-preserving strategy in speech production.
Adaptive fuzzy sliding mode control for gantry crane as varying rope length
TRINH LUONG MIEN
2016-08-01
Full Text Available Gantry crane is used quite commonly in hazardous areas, which increasingly requires strict conrol of the gantry crane operation process to improve efficiency and ensure safe gantry crane opeartion. Automated the gantry crane operating process is being applied pupular currently. Gantry crane is often affected by large noise, having the varying- model parameters, so that proposed a apdaptive fuzzy combining sliding mode controller for the gantry crane in this article. This control method derived from combining the sliding surfaces of three subsystem of the gantry crane (trolley position, rope length, anti-swing to draw out two system sliding surfaces: the trolley positon with the anti-swing and the rope length and the anti-swing. On the based of the sliding mode control principle,drawn out the equivalent controller and the switching controller for gantry crane. But due to the uncertain parameters - nonlinear model of gantry crane with the bound disturbances, combining the fuzzy approximate method, defined the fuzzy controller (used to minic the equivalent controller and the compensation controller for the difference between the equivalent controller and the fuzzy controller (used as the switching controller for two system control inputs: trolley position and rope length The adaptive control laws for these controllers were deduced from Lyapunov’s stable criteria to asymptotically stabilize the sliding surfaces. Simulation results demonstrated the feasibility of the suggested method through grantry crane in the hazard areas.
A two-scale damage model with material length
Dascalu, Cristian
2009-09-01
The Note presents the formulation of a class of two-scale damage models involving a micro-structural length. A homogenization method based on asymptotic developments is employed to deduce the macroscopic damage equations. The damage model completely results from energy-based micro-crack propagation laws, without supplementary phenomenological assumptions. We show that the resulting two-scale model has the property of capturing micro-structural lengths. When damage evolves, the micro-structural length is given by the ratio of the surface density of energy dissipated during the micro-crack growth and the macroscopic damage energy release rate per unit volume of the material. The use of fracture criteria based on resistance curves or power laws for sub-critical growth of micro-cracks leads to quasi-brittle and, respectively, time-dependent damage models. To cite this article: C. Dascalu, C. R. Mecanique 337 (2009).
Implementation Of Path Length Control For RLG Using FPGA
Prasanthi.Pasula
2012-02-01
Full Text Available Ring Laser Gyro(RLG is used to sense angular information accurately and precisely.In a RLG,an optical ring is formed,and two laser beams are directed around the ring in opposite directions.When the beams are combined ,rotation of the ring appears as an interference shift in the combined beams.The amplitude of modulation of the light intensity is less .When RLG is operating at its peak, in comparison to when it is operating with pathlength which is either under or over the peak path length.It is difficult to detect,modulations at peak.The analog components are used to form a phase comparator.The voltage produced by a photo detector actuated by a small sample of light which is picked off by the laser beam.If two signals are in phase ,then the voltage to the PZT is increased,if it is out of phase ,it is decreased.The analog phase comparator and voltage feedback device suffers from the drawbacks of analog devices radiation softness bulk,weight, lack of tolerence.To overcome the above problem, path length control using FPGA is implemented.
Temporal coherence length of light in semiclassical field theory models
Jagielski, Borys; Vistnes, Arnt Inge
2010-01-01
The following work is motivated by the conceptual problems associated with the wave-particle duality and the notion of the photon. Two simple classical models for radiation from individual emitters are compared, one based on sines with random phasejumps, another based on pulse trains. The sum signal is calculated for a varying number of emitters. The focus lies on the final signal's statistical features quantified by means of the temporal coherence function and the temporal coherence length. We show how these features might be used to experimentally differentiate between the models. We also point to ambiguities in the definition of the temporal coherence length.
Cheung, S.-K.; Berg, H. van den; Boucherie, R.J.
2005-01-01
We obtain a decomposition result for the steady state queue length distribution in egalitarian processor-sharing (PS) models. In particular, for multi-class egalitarian PS queues, we show that the marginal queue length distribution for each class equals the queue length distribution of an equivalent
Modified pendulum model for mean step length estimation.
González, Rafael C; Alvarez, Diego; López, Antonio M; Alvarez, Juan C
2007-01-01
Step length estimation is an important issue in areas such as gait analysis, sport training or pedestrian localization. It has been shown that the mean step length can be computed by means of a triaxial accelerometer placed near the center of gravity of the human body. Estimations based on the inverted pendulum model are prone to underestimate the step length, and must be corrected by calibration. In this paper we present a modified pendulum model in which all the parameters correspond to anthropometric data of the individual. The method has been tested with a set of volunteers, both males and females. Experimental results show that this method provides an unbiased estimation of the actual displacement with a standard deviation lower than 2.1%.
Adding Curvature to Minimum Description Length Shape Models
Thodberg, Hans Henrik; Ólafsdóttir, Hildur
2003-01-01
The Minimum Description Length (MDL) approach to shape modelling seeks a compact description of a set of shapes in terms of the coordinates of marks on the shapes. It has been shown that the mark positions resulting from this optimisation to a large extent solve the so-called point correspondence...
Optically controlled thermal management on the nanometer length scale
Garwe, F [Institute of Photonic Technology (IPHT) Jena, PO Box 100239, D-07745 Jena (Germany); Bauerschaefer, U [GmBU, Erich-Neuss-Weg 5, D-06120 Halle/S (Germany); Csaki, A [Institute of Photonic Technology (IPHT) Jena, PO Box 100239, D-07745 Jena (Germany); Steinbrueck, A [Institute of Photonic Technology (IPHT) Jena, PO Box 100239, D-07745 Jena (Germany); Ritter, K [Technical University Ilmenau, D-98693 Ilmenau (Germany); Bochmann, A [Institute of Photonic Technology (IPHT) Jena, PO Box 100239, D-07745 Jena (Germany); Bergmann, J [Institute of Photonic Technology (IPHT) Jena, PO Box 100239, D-07745 Jena (Germany); Weise, A [Friedrich Schiller University Jena, Institute of Human Genetics and Anthropology, D-07702 Jena (Germany); Akimov, D [Friedrich Schiller University Jena, Institute of Physical Chemistry, D-07743 Jena (Germany); Maubach, G [Institute of Photonic Technology (IPHT) Jena, PO Box 100239, D-07745 Jena (Germany); Koenig, K [Fraunhofer Institut St Ingbert, D-07702 St Ingbert (Germany); Huettmann, G [Medical Laser Center Luebeck, D-23552 Luebeck (Germany); Paa, W [Institute of Photonic Technology (IPHT) Jena, PO Box 100239, D-07745 Jena (Germany); Popp, J [Institute of Photonic Technology (IPHT) Jena, PO Box 100239, D-07745 Jena (Germany); Fritzsche, W [Institute of Photonic Technology (IPHT) Jena, PO Box 100239, D-07745 Jena (Germany)
2008-02-06
The manipulation of polymers and biological molecules or the control of chemical reactions on a nanometer scale by means of laser pulses shows great promise for applications in modern nanotechnology, biotechnology, molecular medicine or chemistry. A controllable, parallel, highly efficient and very local heat conversion of the incident laser light into metal nanoparticles without ablation or fragmentation provides the means for a tool like a 'nanoreactor', a 'nanowelder', a 'nanocrystallizer' or a 'nanodesorber'. In this paper we explain theoretically and show experimentally the interaction of laser radiation with gold nanoparticles on a polymethylmethacrylate (PMMA) layer (one-photon excitation) by means of different laser pulse lengths, wavelengths and pulse repetition rates. To the best of our knowledge this is the first report showing the possibility of highly local (in a 40 nm range) regulated heat insertion into the nanoparticle and its surroundings without ablation of the gold nanoparticles. In an earlier paper we showed that near-infrared femtosecond irradiation can cut labeled DNA sequences in metaphase chromosomes below the diffraction-limited spot size. Now, we use gold as well as silver-enhanced gold nanoparticles on DNA (also within chromosomes) as energy coupling objects for femtosecond laser irradiation with single-and two-photon excitation. We show the results of highly localized destruction effects on DNA that occur only nearby the nanoparticles.
Modelling length of hospital stay in motor victims
Mercedes Ayuso-Gutiérrez
2015-03-01
Full Text Available Objective. To analyze which socio-demographic and other factors related to motor injuries affect the length of hospital recovery stay. Materials and methods. In the study a sample of 17 932 motor accidents was used. All the crashes occurred in Spain between 2000 and 2007. Different regression models were fitted to data to identify and measure the impact of a set of explanatory regressors. Results. Time of hospital stay for men is on average 41% larger than for women. When the victim has a fracture as a consequence of the accident, the mean time of hospital stay is multiplied by five. Injuries located in lower extremities, the head and abdomen are associated with greater hospitalization lengths. Conclusions. Gender, age and type of victim, as well as the location and nature of injuries, are found to be factors that have significant impact on the expected length of hospital stay.
A Model for Geometry-Dependent Errors in Length Artifacts.
Sawyer, Daniel; Parry, Brian; Phillips, Steven; Blackburn, Chris; Muralikrishnan, Bala
2012-01-01
We present a detailed model of dimensional changes in long length artifacts, such as step gauges and ball bars, due to bending under gravity. The comprehensive model is based on evaluation of the gauge points relative to the neutral bending surface. It yields the errors observed when the gauge points are located off the neutral bending surface of a bar or rod but also reveals the significant error associated with out-of-straightness of a bar or rod even if the gauge points are located in the neutral bending surface. For example, one experimental result shows a length change of greater than 1.5 µm on a 1 m ball bar with an out-of-straightness of 0.4 mm. This and other results are in agreement with the model presented in this paper.
A simple physical model predicts small exon length variations.
2006-04-01
Full Text Available One of the most common splice variations are small exon length variations caused by the use of alternative donor or acceptor splice sites that are in very close proximity on the pre-mRNA. Among these, three-nucleotide variations at so-called NAGNAG tandem acceptor sites have recently attracted considerable attention, and it has been suggested that these variations are regulated and serve to fine-tune protein forms by the addition or removal of a single amino acid. In this paper we first show that in-frame exon length variations are generally overrepresented and that this overrepresentation can be quantitatively explained by the effect of nonsense-mediated decay. Our analysis allows us to estimate that about 50% of frame-shifted coding transcripts are targeted by nonsense-mediated decay. Second, we show that a simple physical model that assumes that the splicing machinery stochastically binds to nearby splice sites in proportion to the affinities of the sites correctly predicts the relative abundances of different small length variations at both boundaries. Finally, using the same simple physical model, we show that for NAGNAG sites, the difference in affinities of the neighboring sites for the splicing machinery accurately predicts whether splicing will occur only at the first site, splicing will occur only at the second site, or three-nucleotide splice variants are likely to occur. Our analysis thus suggests that small exon length variations are the result of stochastic binding of the spliceosome at neighboring splice sites. Small exon length variations occur when there are nearby alternative splice sites that have similar affinity for the splicing machinery.
Autonomous and FliK-dependent length control of the flagellar rod in Salmonella enterica.
Takahashi, Noriko; Mizuno, Shino; Hirano, Takanori; Chevance, Fabienne F V; Hughes, Kelly T; Aizawa, Shin-Ichi
2009-10-01
Salmonella flgG point mutations produce filamentous rod structures whose lengths are determined by FliK. FliK length variants produce rods with lengths proportional to the corresponding FliK molecular size, suggesting that FliK controls the length of not only the hook but also the rod by the same molecular mechanism.
Autonomous and FliK-Dependent Length Control of the Flagellar Rod in Salmonella enterica▿
Takahashi, Noriko; Mizuno, Shino; Hirano, Takanori; Chevance, Fabienne F. V.; Hughes, Kelly T.; Aizawa, Shin-Ichi
2009-01-01
Salmonella flgG point mutations produce filamentous rod structures whose lengths are determined by FliK. FliK length variants produce rods with lengths proportional to the corresponding FliK molecular size, suggesting that FliK controls the length of not only the hook but also the rod by the same molecular mechanism. PMID:19666714
Hannah S Bender
Full Text Available Telomeres, specialised structures that protect chromosome ends, play a critical role in preserving chromosome integrity. Telomere dynamics in the Tasmanian devil (Sarcophilus harrisii are of particular interest in light of the emergence of devil facial tumour disease (DFTD, a transmissible malignancy that causes rapid mortality and threatens the species with extinction. We used fluorescent in situ hybridisation to investigate telomere length in DFTD cells, in healthy Tasmanian devils and in four closely related marsupial species. Here we report that animals in the Order Dasyuromorphia have chromosomes characterised by striking telomere length dimorphism between homologues. Findings in sex chromosomes suggest that telomere length dimorphism may be regulated by events in the parental germlines. Long telomeres on the Y chromosome imply that telomere lengthening occurs during spermatogenesis, whereas telomere diminution occurs during oogenesis. Although found in several somatic cell tissue types, telomere length dimorphism was not found in DFTD cancer cells, which are characterised by uniformly short telomeres. This is, to our knowledge, the first report of naturally occurring telomere length dimorphism in any species and suggests a novel strategy of telomere length control. Comparative studies in five distantly related marsupials and a monotreme indicate that telomere dimorphism evolved at least 50 million years ago.
A new algebraic transition model based on stress length function
Xiao, Meng-Juan; She, Zhen-Su
2016-11-01
Transition, as one of the two biggest challenges in turbulence research, is of critical importance for engineering application. For decades, the fundamental research seems to be unable to capture the quantitative details in real transition process. On the other hand, numerous empirical parameters in engineering transition models provide no unified description of the transition under varying physical conditions. Recently, we proposed a symmetry-based approach to canonical wall turbulence based on stress length function, which is here extended to describe the transition via a new algebraic transition model. With a multi-layer analytic form of the stress length function in both the streamwise and wall normal directions, the new model gives rise to accurate description of the mean field and friction coefficient, comparing with both the experimental and DNS results at different inlet conditions. Different types of transition process, such as the transition with varying incoming turbulence intensities or that with blow and suck disturbance, are described by only two or three model parameters, each of which has their own specific physical interpretation. Thus, the model enables one to extract physical information from both experimental and DNS data to reproduce the transition process, which may prelude to a new class of generalized transition model for engineering applications.
Mathematical model of alternative mechanism of telomere length maintenance
Kollár, Richard; Nosek, Jozef; Tomaska, Lubomir
2014-01-01
Biopolymer length regulation is a complex process that involves a large number of subprocesses acting simultaneously across multiple spatial and temporal scales. An illustrative example important for genomic stability is the length regulation of telomeres---nucleo-protein structures at the ends of linear chromosomes. Maintenance of telomeres is often facilitated by the enzyme telomerase but, particularly in telomerase-free systems, the maintenance of chromosomal termini depends on alternative lengthening of telomeres (ALT) mechanisms mediated by recombination. Various linear and circular DNA structures were identified to participate in ALT, however, dynamics of the whole process is still poorly understood. We propose a chemical kinetics model of ALT with kinetic rates systematically derived from the biophysics of DNA diffusion and looping. The reaction system is reduced to a coagulation-fragmentation system by quasi-steady state approximation. The detailed treatment of kinetic rates yields explicit formulae f...
Three-dimensional suction flow control and suction jet length optimization of NACA 0012 wing
Yousefi, Kianoosh; Saleh, Reza
2015-01-01
A three-dimensional suction flow control study was performed to investigate the aerodynamic characteristics of a rectangular wing with a NACA 0012 airfoil section. In addition, the optimum suction jet length was determined. In this study, the Reynolds-averaged Navier–Stokes equations were employed in conjunction with a k–ω SST turbulent model. Perpendicular suction was applied at the leading edge of the wing's upper surface, with two different types of slot distributions: i.e., center suction...
A polarised population of dynamic microtubules mediates homeostatic length control in animal cells.
Remigio Picone
Full Text Available Because physical form and function are intimately linked, mechanisms that maintain cell shape and size within strict limits are likely to be important for a wide variety of biological processes. However, while intrinsic controls have been found to contribute to the relatively well-defined shape of bacteria and yeast cells, the extent to which individual cells from a multicellular animal control their plastic form remains unclear. Here, using micropatterned lines to limit cell extension to one dimension, we show that cells spread to a characteristic steady-state length that is independent of cell size, pattern width, and cortical actin. Instead, homeostatic length control on lines depends on a population of dynamic microtubules that lead during cell extension, and that are aligned along the long cell axis as the result of interactions of microtubule plus ends with the lateral cell cortex. Similarly, during the development of the zebrafish neural tube, elongated neuroepithelial cells maintain a relatively well-defined length that is independent of cell size but dependent upon oriented microtubules. A simple, quantitative model of cellular extension driven by microtubules recapitulates cell elongation on lines, the steady-state distribution of microtubules, and cell length homeostasis, and predicts the effects of microtubule inhibitors on cell length. Together this experimental and theoretical analysis suggests that microtubule dynamics impose unexpected limits on cell geometry that enable cells to regulate their length. Since cells are the building blocks and architects of tissue morphogenesis, such intrinsically defined limits may be important for development and homeostasis in multicellular organisms.
Mask roughness induced LER: geometric model at long correlation lengths
McClinton, Brittany M.; Naulleau, Patrick P.
2011-02-11
Collective understanding of how both the resist and line-edge roughness (LER) on the mask affect the final printed LER has made significant advances. What is poorly understood, however, is the extent to which mask surface roughness couples to image plane LER as a function of illumination conditions, NA, and defocus. Recently, progress has been made in formulating a simplified solution for mask roughness induced LER. Here, we investigate the LER behavior at long correlation lengths of surface roughness on the mask. We find that for correlation lengths greater than 3/NA in wafer dimensions and CDs greater than approximately 0.75/NA, the previously described simplified model, which remains based on physical optics, converges to a 'geometric regime' which is based on ray optics and is independent of partial coherence. In this 'geometric regime', the LER is proportional to the mask slope error as it propagates through focus, and provides a faster alternative to calculating LER in contrast to either full 2D aerial image simulation modeling or the newly proposed physical optics model. Data is presented for both an NA = 0.32 and an NA = 0.5 imaging system for CDs of 22-nm and 50-nm horizontal-line-dense structures.
Density Functional Theory and Materials Modeling at Atomistic Length Scales
Swapan K. Ghosh
2002-04-01
Full Text Available Abstract: We discuss the basic concepts of density functional theory (DFT as applied to materials modeling in the microscopic, mesoscopic and macroscopic length scales. The picture that emerges is that of a single unified framework for the study of both quantum and classical systems. While for quantum DFT, the central equation is a one-particle Schrodinger-like Kohn-Sham equation, the classical DFT consists of Boltzmann type distributions, both corresponding to a system of noninteracting particles in the field of a density-dependent effective potential, the exact functional form of which is unknown. One therefore approximates the exchange-correlation potential for quantum systems and the excess free energy density functional or the direct correlation functions for classical systems. Illustrative applications of quantum DFT to microscopic modeling of molecular interaction and that of classical DFT to a mesoscopic modeling of soft condensed matter systems are highlighted.
Solvable Models on Noncommutative Spaces with Minimal Length Uncertainty Relations
Dey, Sanjib
2014-01-01
Our main focus is to explore different models in noncommutative spaces in higher dimensions. We provide a procedure to relate a three dimensional q-deformed oscillator algebra to the corresponding algebra satisfied by canonical variables describing non-commutative spaces. The representations for the corresponding operators obey algebras whose uncertainty relations lead to minimal length, areas and volumes in phase space, which are in principle natural candidates of many different approaches of quantum gravity. We study some explicit models on these types of noncommutative spaces, first by utilising the perturbation theory, later in an exact manner. In many cases the operators are not Hermitian, therefore we use PT -symmetry and pseudo-Hermiticity property, wherever applicable, to make them self-consistent. Apart from building mathematical models, we focus on the physical implications of noncommutative theories too. We construct Klauder coherent states for the perturbative and nonperturbative noncommutative ha...
Accurate length control of supramolecular oligomerization: Vernier assemblies.
Hunter, Christopher A; Tomas, Salvador
2006-07-12
Linear oligomeric supramolecular assemblies of defined length have been generated using the Vernier principle. Two molecules, containing a different number (n and m) of mutually complementary binding sites, separated by the same distance, interact with each other to form an assembly of length (n x m). The assembly grows in the same way as simple supramolecular polymers, but at a molecular stop signal, when the binding sites come into register, the assembly terminates giving an oligomer of defined length. This strategy has been realized using tin and zinc porphyrin oligomers as the molecular building blocks. In the presence of isonicotinic acid, a zinc porphyrin trimer and a tin porphyrin dimer form a 3:4 triple stranded Vernier assembly six porphyrins long. The triple strand Vernier architecture introduced here adds an additional level of cooperativity, yielding a stability and selectivity that cannot be achieved via a simple Vernier approach. The assembly properties of the system were characterized using fluorescence titrations and size-exclusion chromatography (SEC). Assembly of the Vernier complex is efficient at micromolar concentrations in nonpolar solvents, and under more competitive conditions, a variety of fragmentation assemblies can be detected, allowing determination of the stability constants for this system and detailed speciation profiles to be constructed.
Controlling the Focal Length and the Spot Size in Flying Optics by Dual-deformable-mirror-systems
ZHAO Quanzhong; CHENG Zhaogu; GAO Haijun; CHAI Xiongliang; LUO Hongxin
2002-01-01
The models of several dual-deformable-mirror-systems,which can control focal the length and the spot size in flying optics,were introduced and their operating principle and adjusting characteristics were analyzed.The simulation results indicate that dual-deformable-mirror-systems can control the focal length and the spot size.This research is a good guidance to engineering application of dual-deformable-mirror-systems.
Wind adaptive modeling of transmission lines using minimum description length
Jaw, Yoonseok; Sohn, Gunho
2017-03-01
The transmission lines are moving objects, which positions are dynamically affected by wind-induced conductor motion while they are acquired by airborne laser scanners. This wind effect results in a noisy distribution of laser points, which often hinders accurate representation of transmission lines and thus, leads to various types of modeling errors. This paper presents a new method for complete 3D transmission line model reconstruction in the framework of inner and across span analysis. The highlighted fact is that the proposed method is capable of indirectly estimating noise scales, which corrupts the quality of laser observations affected by different wind speeds through a linear regression analysis. In the inner span analysis, individual transmission line models of each span are evaluated based on the Minimum Description Length theory and erroneous transmission line segments are subsequently replaced by precise transmission line models with wind-adaptive noise scale estimated. In the subsequent step of across span analysis, detecting the precise start and end positions of the transmission line models, known as the Point of Attachment, is the key issue for correcting partial modeling errors, as well as refining transmission line models. Finally, the geometric and topological completion of transmission line models are achieved over the entire network. A performance evaluation was conducted over 138.5 km long corridor data. In a modest wind condition, the results demonstrates that the proposed method can improve the accuracy of non-wind-adaptive initial models on an average of 48% success rate to produce complete transmission line models in the range between 85% and 99.5% with the positional accuracy of 9.55 cm transmission line models and 28 cm Point of Attachment in the root-mean-square error.
[Case-control study on methods of limb length control in hip arthroplasty].
Zhang, Yang-yang; Zuo, Jian-lin; Gao, Zhong-li
2016-02-01
To introduce a new measuring tool for measuring postoperative limb length exactly, and to provide a convenient and effective method to control limb length after total hip replacement. From January 2013 to September 2014, 102 patients undergoing primary unilateral hip replacement were divided into two groups: experimental group and control group. There were 51 patients in the experimental group, including 25 males and 26 females, ranging in age from 37 to 92 years old, with an average of 60.41 years old. The patients in experimental group were treated with new method to control limb length. Other 51 patients in the control group, including 27 males and 24 females, ranging in age from 35 to 87 years old, with an average of 61.00 years old. The patients in the control group were treated with normal methods such as shuck test or limb touching. All the patients were operated by the same experienced surgeon. In the experimental group,total hip arthroplasties (THA) were performed on 35 patients with avascular necrosis of the femoral head or femoral neck fracture, and 16 patients were treated with hemiarthroplasty (HA). In the control group, 38 patients received THA and 13 patients received HA. On the anterior-posterior X-ray radiograph, several indexes were measured as follows: the distance of bilateral femoral offset (a), the height from tip of great trochanter to the rotation center of the femoral head (b) and the vertical distance between the top of the minor trochanter and the two tear drops line (c). The leg length discrepancy can be assessed with three parameters as follows: d1, the absolute value of the difference between the bilateral a values; d2, the difference between the bilateral b values; d3, the difference between the bilateral c values. The SPSS 21.0 was applied for the statistical analysis. In the experimental and control groups, d1 were 4.49 mm and 7.32 mm (P = 0.013); d2 were 2.37 mm and 4.32 mm (P = 0.033); d3 were 3.32 mm and 6.08 mm (P = 0.031). The
QTL mapping and candidate gene analysis of telomere length control factors in maize (Zea mays L.)
Telomere length is under genetic control and important for essential telomere functions. Failure to regulate telomere length homeostasis contributes to cancers and aging-related diseases in animals, but the effects of telomere length defects in plants remains poorly understood. To learn more about t...
Modelling Time and Length Scales of Scour Around a Pipeline
Smith, H. D.; Foster, D. L.
2002-12-01
The scour and burial of submarine objects is an area of interest for engineers, oceanographers and military personnel. Given the limited availability of field observations, there exists a need to accurately describe the hydrodynamics and sediment response around an obstacle using numerical models. In this presentation, we will compare observations of submarine pipeline scour with model predictions. The research presented here uses the computational fluid dynamics (CFD) model FLOW-3D. FLOW-3D, developed by Flow Science in Santa Fe, NM, is a 3-dimensional finite-difference model that solves the Navier-Stokes and continuity equations. Using the Volume of Fluid (VOF) technique, FLOW-3D is able to resolve fluid-fluid and fluid-air interfaces. The FAVOR technique allows for complex geometry to be resolved with rectangular grids. FLOW-3D uses a bulk transport method to describe sediment transport and feedback to the hydrodynamic solver is accomplished by morphology evolution and fluid viscosity due to sediment suspension. Previous investigations by the authors have shown FLOW-3D to well-predict the hydrodynamics around five static scoured bed profiles and a stationary pipeline (``Modelling of Flow Around a Cylinder Over a Scoured Bed,'' submit to Journal of Waterway, Port, Coastal, and Ocean Engineering). Following experiments performed by Mao (1986, Dissertation, Technical University of Denmark), we will be performing model-data comparisons of length and time scales for scour around a pipeline. Preliminary investigations with LES and k-ɛ closure schemes have shown that the model predicts shorter time scales in scour hole development than that observed by Mao. Predicted time and length scales of scour hole development are shown to be a function of turbulence closure scheme, grain size, and hydrodynamic forcing. Subsequent investigations consider variable wave-current flow regimes and object burial. This investigation will allow us to identify different regimes for the
Mathematical model of alternative mechanism of telomere length maintenance
Kollár, Richard; Bod'ová, Katarína; Nosek, Jozef; Tomáška, L'ubomír
2014-03-01
Biopolymer length regulation is a complex process that involves a large number of biological, chemical, and physical subprocesses acting simultaneously across multiple spatial and temporal scales. An illustrative example important for genomic stability is the length regulation of telomeres—nucleoprotein structures at the ends of linear chromosomes consisting of tandemly repeated DNA sequences and a specialized set of proteins. Maintenance of telomeres is often facilitated by the enzyme telomerase but, particularly in telomerase-free systems, the maintenance of chromosomal termini depends on alternative lengthening of telomeres (ALT) mechanisms mediated by recombination. Various linear and circular DNA structures were identified to participate in ALT, however, dynamics of the whole process is still poorly understood. We propose a chemical kinetics model of ALT with kinetic rates systematically derived from the biophysics of DNA diffusion and looping. The reaction system is reduced to a coagulation-fragmentation system by quasi-steady-state approximation. The detailed treatment of kinetic rates yields explicit formulas for expected size distributions of telomeres that demonstrate the key role played by the J factor, a quantitative measure of bending of polymers. The results are in agreement with experimental data and point out interesting phenomena: an appearance of very long telomeric circles if the total telomere density exceeds a critical value (excess mass) and a nonlinear response of the telomere size distributions to the amount of telomeric DNA in the system. The results can be of general importance for understanding dynamics of telomeres in telomerase-independent systems as this mode of telomere maintenance is similar to the situation in tumor cells lacking telomerase activity. Furthermore, due to its universality, the model may also serve as a prototype of an interaction between linear and circular DNA structures in various settings.
First Exon Length Controls Active Chromatin Signatures and Transcription
Nicole I. Bieberstein
2012-07-01
Full Text Available Here, we explore the role of splicing in transcription, employing both genome-wide analysis of human ChIP-seq data and experimental manipulation of exon-intron organization in transgenic cell lines. We show that the activating histone modifications H3K4me3 and H3K9ac map specifically to first exon-intron boundaries. This is surprising, because these marks help recruit general transcription factors (GTFs to promoters. In genes with long first exons, promoter-proximal levels of H3K4me3 and H3K9ac are greatly reduced; consequently, GTFs and RNA polymerase II are low at transcription start sites (TSSs and exhibit a second, promoter-distal peak from which transcription also initiates. In contrast, short first exons lead to increased H3K4me3 and H3K9ac at promoters, higher expression levels, accuracy in TSS usage, and a lower frequency of antisense transcription. Therefore, first exon length is predictive for gene activity. Finally, splicing inhibition and intron deletion reduce H3K4me3 levels and transcriptional output. Thus, gene architecture and splicing determines transcription quantity and quality as well as chromatin signatures.
MacPherson, Megan K.; Smith, Anne
2013-01-01
Purpose: To investigate the potential effects of increased sentence length and syntactic complexity on the speech motor control of children who stutter (CWS). Method: Participants repeated sentences of varied length and syntactic complexity. Kinematic measures of articulatory coordination variability and movement duration during perceptually…
MacPherson, Megan K.; Smith, Anne
2013-01-01
Purpose: To investigate the potential effects of increased sentence length and syntactic complexity on the speech motor control of children who stutter (CWS). Method: Participants repeated sentences of varied length and syntactic complexity. Kinematic measures of articulatory coordination variability and movement duration during perceptually…
Harari, Yaniv; Romano, Gal-Hagit; Ungar, Lior; Kupiec, Martin
2013-11-15
Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic chromosomes, thus protecting their stability and integrity. They play important roles in DNA replication and repair and are central to our understanding of aging and cancer development. In rapidly dividing cells, telomere length is maintained by the activity of telomerase. About 400 TLM (telomere length maintenance) genes have been identified in yeast, as participants of an intricate homeostasis network that keeps telomere length constant. Two papers have recently shown that despite this extremely complex control, telomere length can be manipulated by external stimuli. These results have profound implications for our understanding of cellular homeostatic systems in general and of telomere length maintenance in particular. In addition, they point to the possibility of developing aging and cancer therapies based on telomere length manipulation.
Raul Garcia-Segura
2017-09-01
Full Text Available Electric arc furnaces (EAFs contribute to almost one third of the global steel production. Arc furnaces use a large amount of electrical energy to process scrap or reduced iron and are relevant to study because small improvements in their efficiency account for significant energy savings. Optimal controllers need to be designed and proposed to enhance both process performance and energy consumption. Due to the random and chaotic nature of the electric arcs, neural networks and other soft computing techniques have been used for modeling EAFs. This study proposes a methodology for modeling EAFs that considers the time varying arc length as a relevant input parameter to the arc furnace model. Based on actual voltages and current measurements taken from an arc furnace, it was possible to estimate an arc length suitable for modeling the arc furnace using neural networks. The obtained results show that the model reproduces not only the stable arc conditions but also the unstable arc conditions, which are difficult to identify in a real heat process. The presented model can be applied for the development and testing of control systems to improve furnace energy efficiency and productivity.
Controlled reattachment in separated flows: a variational approach to recirculation length reduction
Boujo, E
2014-01-01
A variational technique is used to derive analytical expressions for the sensitivity of recirculation length to steady forcing in separated flows. Linear sensitivity analysis is applied to the two-dimensional steady flow past a circular cylinder for Reynolds numbers $40 \\leq Re \\leq 120$, both in the subcritical and supercritical regimes. Regions which are the most sensitive to volume forcing and wall blowing/suction are identified. Control configurations which reduce the recirculation length are designed based on the sensitivity information, in particular small cylinders used as control devices in the wake of the main cylinder, and fluid suction at the cylinder wall. Validation against full non-linear Navier-Stokes calculations shows excellent agreement for small-amplitude control. The linear stability properties of the controlled flow are systematically investigated. At moderate Reynolds numbers, we observe that regions where control reduces the recirculation length correspond to regions where it has a stab...
孙振国; 陈念; 陈强
2003-01-01
Methods of arc length control and visual image based weld detection for precision pulse TIG welding were investigated. With a particular all-hardware circuit, arc voltage during peak current stage is sampled and integrated to indicate arc length, deviation of arc length and adjusting parameters are calculated and output to drive a step motor directly. According to the features of welding image grabbed with CCD camera, a special algorithm was developed to detect the central line of weld fast and accurately. Then an application system were established, whose static arc length error is ±0.1 mm with 20 A average current and 1 mm given arc length, static detection precision of weld is 0.01 mm, processing time of each image is less than 120 ms. Precision pulse TIG welding of some given thin stainless steel components with complicated curved surface was successfully realized.
Does an inter-flaw length control the accuracy of rupture forecasting in geological materials?
Vasseur, Jérémie; Wadsworth, Fabian B.; Heap, Michael J.; Main, Ian G.; Lavallée, Yan; Dingwell, Donald B.
2017-10-01
Multi-scale failure of porous materials is an important phenomenon in nature and in material physics - from controlled laboratory tests to rockbursts, landslides, volcanic eruptions and earthquakes. A key unsolved research question is how to accurately forecast the time of system-sized catastrophic failure, based on observations of precursory events such as acoustic emissions (AE) in laboratory samples, or, on a larger scale, small earthquakes. Until now, the length scale associated with precursory events has not been well quantified, resulting in forecasting tools that are often unreliable. Here we test the hypothesis that the accuracy of the forecast failure time depends on the inter-flaw distance in the starting material. We use new experimental datasets for the deformation of porous materials to infer the critical crack length at failure from a static damage mechanics model. The style of acceleration of AE rate prior to failure, and the accuracy of forecast failure time, both depend on whether the cracks can span the inter-flaw length or not. A smooth inverse power-law acceleration of AE rate to failure, and an accurate forecast, occurs when the cracks are sufficiently long to bridge pore spaces. When this is not the case, the predicted failure time is much less accurate and failure is preceded by an exponential AE rate trend. Finally, we provide a quantitative and pragmatic correction for the systematic error in the forecast failure time, valid for structurally isotropic porous materials, which could be tested against larger-scale natural failure events, with suitable scaling for the relevant inter-flaw distances.
Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.
Alex S Nord
Full Text Available BACKGROUND: High-throughput mutagenesis of the mammalian genome is a powerful means to facilitate analysis of gene function. Gene trapping in embryonic stem cells (ESCs is the most widely used form of insertional mutagenesis in mammals. However, the rules governing its efficiency are not fully understood, and the effects of vector design on the likelihood of gene-trapping events have not been tested on a genome-wide scale. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we used public gene-trap data to model gene-trap likelihood. Using the association of gene length and gene expression with gene-trap likelihood, we constructed spline-based regression models that characterize which genes are susceptible and which genes are resistant to gene-trapping techniques. We report results for three classes of gene-trap vectors, showing that both length and expression are significant determinants of trap likelihood for all vectors. Using our models, we also quantitatively identified hotspots of gene-trap activity, which represent loci where the high likelihood of vector insertion is controlled by factors other than length and expression. These formalized statistical models describe a high proportion of the variance in the likelihood of a gene being trapped by expression-dependent vectors and a lower, but still significant, proportion of the variance for vectors that are predicted to be independent of endogenous gene expression. CONCLUSIONS/SIGNIFICANCE: The findings of significant expression and length effects reported here further the understanding of the determinants of vector insertion. Results from this analysis can be applied to help identify other important determinants of this important biological phenomenon and could assist planning of large-scale mutagenesis efforts.
Surface roughness length dynamic over several different surfaces and its effects on modeling fluxes
2006-01-01
<正>Roughness length and zero-plane displacement over three typical surfaces were calculated iteratively by least-square method, which are Yucheng Experimental Station for agriculture surfaces, Qianyanzhou Experimental Station for complex and undulant surfaces, and Changbai Mountains Experimental Station for forest surfaces. On the basis of roughness length dynamic, the effects of roughness length dynamic on fluxes were analyzed with SEBS model. The results indicate that, aerodynamic roughness length changes with vegetation conditions (such as vegetation height, LAI), wind speed, friction velocity and some other factors. In Yucheng and Changbai Mountains Experimental Station, aerodynamic roughness length over the fetch of flux tower changes with vegetation height and LAI obviously, that is, with the increase of LAI, roughness length increases to the peak value firstly, and then decreases. In Qianyanzhou Experimental Station, LAI changes slightly, so the relationship between roughness length and LAI is not obvious. The aerodynamic roughness length of Yucheng and Changbai Mountains Experimental Station changes slightly with wind direction, while aerodynamic roughness length of Qianyanzhou Experimental Station changes obviously with wind direction. The reason for that is the terrain in Yucheng and Changbai Mountains Experimental Station is relatively flat, while in Qianyanzhou Experimental Station the terrain is very undulant and heterogeneous. With the increase of wind speed, aerodynamic roughness length of Yucheng Experimental Station changes slightly, while it decreases obviously in Qianyanzhou Experimental Station and Changbai Mountains Experimental Station. Roughness length dynamic takes great effects on fluxes calculation, and the effects are analyzed by SEBS model. By comparing 1 day averaged roughness length in Yucheng Experimental Station and 5 day averaged roughness length of Qianyanzhou and Changbai Mountains Experimental Station with roughness length
Trajectory tracking control of variable length pendulum by partial energy shaping
Xin, Xin; Liu, Yannian
2014-05-01
This paper concerns a trajectory tracking control problem for a pendulum with variable length, which is an underactuated mechanical system of two degrees-of-freedom with a single input of adjusting the length of the pendulum. We aim to study whether it is possible to design a time-invariant control law to pump appropriate energy into the variable length pendulum for achieving a desired swing motion (trajectory) with given desired energy and length of the pendulum. First, we show that it is difficult to avoid singular points in the controller designed by using the conventional energy-based control approach in which the total mechanical energy of the pendulum is controlled. Second, we present a tracking controller free of singular points by using only the kinetic energy of rotation and the potential energy of the pendulum and not using the kinetic energy of the motion along the rod. Third, we analyze globally the motion of the pendulum and clarify the stability issue of two closed-loop equilibrium points; and we also provide some conditions on control parameters for achieving the tracking objective. Finally, we show numerical simulation results to validate the presented theoretical results.
Multivalent nanofibers of a controlled length: regulation of bacterial cell agglutination.
Lee, Dong-Woo; Kim, Taehoon; Park, Il-Soo; Huang, Zhegang; Lee, Myongsoo
2012-09-12
Control of the size and shape of molecular assemblies on the nanometer scale in aqueous solutions is very important for the regulation of biological functions. Among the well-defined supramolecular structures of organic amphiphiles, one-dimensional nanofibers have attracted much attention because of their potential applications in biocompatible materials. Although much progress has been made in the field of self-assembled nanofibers, the ability to control the fiber length remains limited. The approach for control of the fiber length presented herein overcomes this limitation through the coassembly of amphiphilic rod-coil molecules in which the crystallinity of the aromatic segment can be regulated by π-π stacking interactions. The introduction of carbohydrate segments into the fiber exterior endows the nanofibers with the ability to adhere to bacterial cells. Notably, the fiber length systematically regulates the agglutination and proliferation of bacterial cells exposed to these fibers.
Molecular Control of Flowering in Response to Day Length in Rice (F)
Vittoria Brambilla; Fabio Fornara
2013-01-01
Flowering at the most appropriate times of the year requires careful monitoring of environmental conditions and correct integration of such information with an endogenous molecular network.Rice (Oryza sativa) is a facultative short day plant,and flowers quickly under short day lengths,as opposed to Arabidopsis thaliana whose flowering is accelerated by longer days.Despite these physiological differences,several genes controlling flowering in response to day length (or photoperiod) are conserved between rice and Arabidopsis,and the molecular mechanisms involved are similar.Inductive day lengths trigger expression of florigenic proteins in leaves that can move to the shoot apical meristem to induce reproductive development.As compared to Arabidopsis,rice also possesses unique factors that regulate expression of florigenic genes.Here,we discuss recent advances in understanding the molecular mechanisms involved in day length perception,production of florigenic signals,and molecular responses of the shoot apical meristem to florigenic proteins.
Auto-Regressive Models of Non-Stationary Time Series with Finite Length
FEI Wanchun; BAI Lun
2005-01-01
To analyze and simulate non-stationary time series with finite length, the statistical characteristics and auto-regressive (AR) models of non-stationary time series with finite length are discussed and studied. A new AR model called the time varying parameter AR model is proposed for solution of non-stationary time series with finite length. The auto-covariances of time series simulated by means of several AR models are analyzed. The result shows that the new AR model can be used to simulate and generate a new time series with the auto-covariance same as the original time series. The size curves of cocoon filaments regarded as non-stationary time series with finite length are experimentally simulated. The simulation results are significantly better than those obtained so far, and illustrate the availability of the time varying parameter AR model. The results are useful for analyzing and simulating non-stationary time series with finite length.
On the use of the Prandtl mixing length model in the cutting torch modeling
Mancinelli, B [Grupo de Descargas Electricas, Departamento Ing. Electromecanica, Universidad Tecnologica Nacional, Regional Venado Tuerto, Laprida 651, Venado Tuerto (2600), Santa Fe (Argentina); Minotti, F O; Kelly, H, E-mail: bmancinelli@arnet.com.ar [Instituto de Fisica del Plasma (CONICET), Departamento de Fisica, Facultad de Ciencias Exactas y Naturales (UBA) Ciudad Universitaria Pab. I, 1428 Buenos Aires (Argentina)
2011-05-01
The Prandtl mixing length model has been used to take into account the turbulent effects in a 30 A high-energy density cutting torch model. In particular, the model requires the introduction of only one adjustable coefficient c corresponding to the length of action of the turbulence. It is shown that the c value has little effect on the plasma temperature profiles outside the nozzle (the differences being less than 10 %), but severely affects the plasma velocity distribution, with differences reaching about 100% at the middle of the nozzle-anode gap. Within the experimental uncertainties it was also found that the value c = 0.08 allows to reproduce both, the experimental data of velocity and temperature
Multilayer Numerical Modeling of Flows through Vegetation Using a Mixing-Length Turbulence Model
Hector Barrios-Piña
2014-07-01
Full Text Available This work focuses on the effects of vegetation on a fluid flow pattern. In this numerical research, we verify the applicability of a simpler turbulence model than the commonly used k-" model to predict the mean flow through vegetation. The novel characteristic of this turbulence model is that the horizontal mixing-length is explicitly calculated and coupled with a multi-layer approach for the vertical mixing-length, within a general three-dimensional eddy-viscosity formulation. This mixing-length turbulence model has been validated in previous works for different kinds of non-vegetated flows. The hydrodynamic numerical model used for simulations is based on the Reynolds-averaged Navier–Stokes equations for shallow water flows, where a vegetation shear stress term is considered to reproduce the effects of drag forces on flow. A second-order approximation is used for spatial discretization and a semi-implicit Lagrangian–Eulerian scheme is used for time discretization. In order to validate the numerical results, we compare them against experimental data reported in the literature. The comparisons are carried out for two cases of study: submerged vegetation and submerged and emergent vegetation, both within an open channel flow.
Arnold, A S; Blemker, S S; Delp, S L
2001-03-01
The hamstrings and psoas muscles are often lengthened surgically in an attempt to correct crouch gait in persons with cerebral palsy. The purpose of this study was to determine if, and under what conditions, medial hamstrings and psoas lengths estimated with a "deformable" musculoskeletal model accurately characterize the lengths of the muscles during walking in individuals with crouch gait. Computer models of four subjects with crouch gait were developed from magnetic resonance (MR) images. These models were used in conjunction with the subjects' measured gait kinematics to calculate the muscle-tendon lengths at the body positions corresponding to walking. The lengths calculated with the MR-based models were normalized and were compared to the lengths estimated using a deformable generic model. The deformable model was either left undeformed and unscaled, or was deformed or scaled to more closely approximate the femoral geometry or bone dimensions of each subject. In most cases, differences between the normalized lengths of the medial hamstrings computed with the deformable and MR-based models were less than 5 mm. Differences in the psoas lengths computed with the deformable and MR-based models were also small (psoas lengths in persons with neuromuscular disorders.
Two body scattering length of Yukawa model on a lattice
De Soto, F; Roiesnel, C; Boucaud, P; Leroy, J P; Pène, O; Boucaud, Ph.
2007-01-01
The extraction of scattering parameters from Euclidean simulations of a Yukawa model in a finite volume with periodic boundary conditions is analyzed both in non relativistic quantum mechanics and in quantum field theory.
Roughness controlled superhydrophobicity on single nanometer length scale with metal nanoparticles
ten Brink, Gert H.; Foley, Nolan; Zwaan, Darin; Kooi, Bart J.; Palasantzas, Georgios
2015-01-01
Here we demonstrate high water pinning nanostructures and trapping of water droplets onto surfaces via control of roughness on a single nanometer length-scale generated by deposition of preformed gas phase distinct copper nanoparticles on hydrophilic and hydrophobic surfaces. It was found that the c
Roughness controlled superhydrophobicity on single nanometer length scale with metal nanoparticles
ten Brink, Gert H.; Foley, Nolan; Zwaan, Darin; Kooi, Bart J.; Palasantzas, Georgios
2015-01-01
Here we demonstrate high water pinning nanostructures and trapping of water droplets onto surfaces via control of roughness on a single nanometer length-scale generated by deposition of preformed gas phase distinct copper nanoparticles on hydrophilic and hydrophobic surfaces. It was found that the
Filter length scale for continuum modeling of subgrid physics
Simeonov, Julian; Calantoni, Joseph
2014-11-01
Modeling the wide range of scales of geophysical processes with direct numerical simulations (DNS) is currently not feasible. It is therefore typical to explicitly resolve only the large energy-containing scales and to parameterize the unresolved small scales. One approach to separate the scales is by means of spatial filters and here we discuss practical considerations regarding the choice of a volume averaging scale L. We use a macroscopically homogeneous scalar field and quantify the smoothness of the filtered field using a noise metric, ν, defined by the standard deviation of the filtered field normalized by the domain-averaged value of the field. For illustration, we consider the continuum modeling of the particle phase in discrete element method (DEM) simulations and the salt fingers in DNS of double-diffusive convection. We find that ν2 follows an inverse power law dependence on L with an exponent and coefficients proportional to the domain-averaged field value. The empirical power law relation can aid in the development of continuum models from fully resolved simulations while also providing uncertainty estimates of the modeled continuum fields.
Leung, K M; Elashoff, R M; Rees, K S; Hasan, M M; Legorreta, A P
1998-03-01
The purpose of this study was to identify factors related to pregnancy and childbirth that might be predictive of a patient's length of stay after delivery and to model variations in length of stay. California hospital discharge data on maternity patients (n = 499,912) were analyzed. Hierarchical linear modeling was used to adjust for patient case mix and hospital characteristics and to account for the dependence of outcome variables within hospitals. Substantial variation in length of stay among patients was observed. The variation was mainly attributed to delivery type (vaginal or cesarean section), the patient's clinical risk factors, and severity of complications (if any). Furthermore, hospitals differed significantly in maternity lengths of stay even after adjustment for patient case mix. Developing risk-adjusted models for length of stay is a complex process but is essential for understanding variation. The hierarchical linear model approach described here represents a more efficient and appropriate way of studying interhospital variations than the traditional regression approach.
Stosic, Jelena; Finni Juutinen, Taija
2011-01-01
The present study investigated the effects of tendon curvature on measurements of tendon length using 3D-kinematic analysis. Curved and straight tendon models were employed for assessing medial gastrocnemius tendon length and strain during hopping (N = 8). Tendon curvature was identified using small reflective markers placed on the skin surface along the length of the tendon and a sum of vectors between the markers from the calcaneous up to the marker at the origin of tendon was calculated. T...
Stosic, Jelena; Finni Juutinen, Taija
2011-01-01
The present study investigated the effects of tendon curvature on measurements of tendon length using 3D-kinematic analysis. Curved and straight tendon models were employed for assessing medial gastrocnemius tendon length and strain during hopping (N = 8). Tendon curvature was identified using small reflective markers placed on the skin surface along the length of the tendon and a sum of vectors between the markers from the calcaneous up to the marker at the origin of tendon was calculated. T...
Increasing LIGO sensitivity by feedforward subtraction of auxiliary length control noise
Meadors, Grant David; Riles, Keith
2013-01-01
LIGO, the Laser Interferometer Gravitational-wave Observatory, has been designed and constructed to measure gravitational wave strain via differential arm length. The LIGO 4-km Michelson arms with Fabry-Perot cavities have auxiliary length control servos for suppressing Michelson motion of the beam-splitter and arm cavity input mirrors, which degrades interferometer sensitivity. We demonstrate how a post-facto pipeline called AMPS improves a data sample from LIGO Science Run~6 with feedforward subtraction. Dividing data into 1024-second windows, AMPS numerically fits filter functions representing the frequency-domain transfer functions from Michelson length channels into the gravitational-wave strain data channel for each window, then subtracts the filtered Michelson channel noise (witness) from the strain channel (target). In this paper we describe the algorithm, assess achievable improvements in sensitivity to astrophysical sources, and consider relevance to future interferometry.
Nominal model predictive control
Grüne, Lars
2013-01-01
5 p., to appear in Encyclopedia of Systems and Control, Tariq Samad, John Baillieul (eds.); International audience; Model Predictive Control is a controller design method which synthesizes a sampled data feedback controller from the iterative solution of open loop optimal control problems.We describe the basic functionality of MPC controllers, their properties regarding feasibility, stability and performance and the assumptions needed in order to rigorously ensure these properties in a nomina...
Nominal Model Predictive Control
Grüne, Lars
2014-01-01
5 p., to appear in Encyclopedia of Systems and Control, Tariq Samad, John Baillieul (eds.); International audience; Model Predictive Control is a controller design method which synthesizes a sampled data feedback controller from the iterative solution of open loop optimal control problems.We describe the basic functionality of MPC controllers, their properties regarding feasibility, stability and performance and the assumptions needed in order to rigorously ensure these properties in a nomina...
Reilly, Kevin J; Spencer, Kristie A
2013-01-01
The current study investigated the processes responsible for selection of sounds and syllables during production of speech sequences in 10 adults with hypokinetic dysarthria from Parkinson's disease, five adults with ataxic dysarthria, and 14 healthy control speakers. Speech production data from a choice reaction time task were analyzed to evaluate the effects of sequence length and practice on speech sound sequencing. Speakers produced sequences that were between one and five syllables in length over five experimental runs of 60 trials each. In contrast to the healthy speakers, speakers with hypokinetic dysarthria demonstrated exaggerated sequence length effects for both inter-syllable intervals (ISIs) and speech error rates. Conversely, speakers with ataxic dysarthria failed to demonstrate a sequence length effect on ISIs and were also the only group that did not exhibit practice-related changes in ISIs and speech error rates over the five experimental runs. The exaggerated sequence length effects in the hypokinetic speakers with Parkinson's disease are consistent with an impairment of action selection during speech sequence production. The absent length effects observed in the speakers with ataxic dysarthria is consistent with previous findings that indicate a limited capacity to buffer speech sequences in advance of their execution. In addition, the lack of practice effects in these speakers suggests that learning-related improvements in the production rate and accuracy of speech sequences involves processing by structures of the cerebellum. Together, the current findings inform models of serial control for speech in healthy speakers and support the notion that sequencing deficits contribute to speech symptoms in speakers with hypokinetic or ataxic dysarthria. In addition, these findings indicate that speech sequencing is differentially impaired in hypokinetic and ataxic dysarthria.
Kevin J Reilly
2013-10-01
Full Text Available The current study investigated the processes responsible for selection of sounds and syllables during production of speech sequences in 10 adults with hypokinetic dysarthria from Parkinson’s disease, 5 adults with ataxic dysarthria, and 14 healthy control speakers. Speech production data from a choice reaction time task were analyzed to evaluate the effects of sequence length and practice on speech sound sequencing. Speakers produced sequences that were between one and five syllables in length over five experimental runs of 60 trials each. In contrast to the healthy speakers, speakers with hypokinetic dysarthria demonstrated exaggerated sequence length effects for both inter-syllable intervals (ISIs and speech error rates. Conversely, speakers with ataxic dysarthria failed to demonstrate a sequence length effect on ISIs and were also the only group that did not exhibit practice-related changes in ISIs and speech error rates over the five experimental runs. The exaggerated sequence length effects in the hypokinetic speakers with Parkinson’s disease are consistent with an impairment of action selection during speech sequence production. The absent length effects observed in the speakers with ataxic dysarthria is consistent with previous findings that indicate a limited capacity to buffer speech sequences in advance of their execution. In addition, the lack of practice effects in these speakers suggests that learning-related improvements in the production rate and accuracy of speech sequences involves processing by structures of the cerebellum. Together, the current findings inform models of serial control for speech in healthy speakers and support the notion that sequencing deficits contribute to speech symptoms in speakers with hypokinetic or ataxic dysarthria. In addition, these findings indicate that speech sequencing is differentially impaired in hypokinetic and ataxic dysarthria.
吴俊; 胡协和; 陈生; 褚健
2003-01-01
The closed-loop stability issue of finite-precision realizations was investigated for digital control-lers implemented in block-floating-point format. The controller coefficient perturbation was analyzed resultingfrom using finite word length (FWL) block-floating-point representation scheme. A block-floating-point FWL closed-loop stability measure was derived which considers both the dynamic range and precision. To facilitate the design of optimal finite-precision controller realizations, a computationally tractable block-floating-point FWL closed-loop stability measure was then introduced and the method of computing the value of this measure for a given controller realization was developed. The optimal controller realization is defined as the solution that maximizes the corresponding measure, and a numerical optimization approach was adopted to solve the resulting optimal realization problem. A numerical example was used to illustrate the design procedure and to compare the optimal controller realization with the initial realization.
Phonon surface scattering controlled length dependence of thermal conductivity of silicon nanowires.
Xie, Guofeng; Guo, Yuan; Li, Baohua; Yang, Liwen; Zhang, Kaiwang; Tang, Minghua; Zhang, Gang
2013-09-21
We present a kinetic model to investigate the anomalous thermal conductivity in silicon nanowires (SiNWs) by focusing on the mechanism of phonon-boundary scattering. Our theoretical model takes into account the anharmonic phonon-phonon scattering and the angle-dependent phonon scattering from the SiNWs surface. For SiNWs with diameter of 27.2 nm, it is found that in the case of specular reflection at lateral boundaries, the thermal conductivity increases as the length increases, even when the length is up to 10 μm, which is considerably longer than the phonon mean free path (MFP). Thus the phonon-phonon scattering alone is not sufficient for obtaining a normal diffusion in nanowires. However, in the case of purely diffuse reflection at lateral boundaries, the phonons diffuse normally and the thermal conductivity converges to a constant when the length of the nanowire is greater than 100 nm. Our model demonstrates that for observing the length dependence of thermal conductivity experimentally, nanowires with smooth and non-contaminated surfaces, and measuring at low temperature, are preferred.
James S. Han; Theodore. Mianowski; Yi-yu. Lin
1999-01-01
The efficacy of fiber length measurement techniques such as digitizing, the Kajaani procedure, and NIH Image are compared in order to determine the optimal tool. Kenaf bast fibers, aspen, and red pine fibers were collected from different anatomical parts, and the fiber lengths were compared using various analytical tools. A statistical analysis on the validity of the...
吴俊; 胡协和; 陈生; 褚健
2003-01-01
The closed-loop stability issue of finite-precision realizations was investigated for digital controllers implemented in block-floating-point format. The controller coefficient perturbation was analyzed resulting from using finite word length (FWL) block-floating-point representation scheme. A block-floating-point FWL closed-loop stability measure was derived which considers both the dynamic range and precision. To facilitate the design of optimal finite-precision controller realizations, a computationally tractable block-floating-point FWL closed-loop stability measure was then introduced and the method of computing the value of this measure for a given controller realization was developed. The optimal controller realization is defined as the solution that maximizes the corresponding measure, and a numerical optimization approach was adopted to solve the resulting optimal realization problem. A numerical example was used to illustrate the design procedure and to compare the optimal controller realization with the initial realization.
A precise length etalon generator controlled by femtosecond mode-locked laser
Šmid, Radek; Čip, Ondřej; Lazar, Josef
2007-09-01
The progress in the field of optical frequency standards is oriented to femtosecond mode-locked lasers stabilized by technique of the optical frequency synthesis. Such a laser produces a supercontinuum light, which is composed of a cluster of coherent frequency components in certain interval of wavelengths. A value of the repetition rate of femtosecond pulses determines (in the frequency domain) spacing of these coherent components. If we control the mode-locked laser by means of i.e. atomic clocks we ensure frequency of these components very stable. With respect to definition of SI unit "one meter" on basis of speed of light the stabilized mode-locked laser can be used for implementation of this definition by non-traditional way. In the work we present our proposal of a system, which converts excellent frequency stability of components generated by the mode-locked laser to a net of discrete absolute lengths represented by a distance of two mirrors of an optical resonator. On basis of theory, the optical resonator with a cavity length has a periodic frequency spectrum Similarly the frequency of i-th comb component could be written as: f i = f ceo + i f rep, where f ceo is the comb offset frequency and f rep is the repetition rate. For the simplicity we presume the offset frequency f ceo equals to zero. If the supercontinuum beam of the mode-locked laser illuminates the resonator and at the same time the cavity length L is adjusted to length L p = c / (2 p f rep ) then both spectra fit. The symbol 'p' is an integer value. It produces intensity maximum in the output of the cavity, which is detected by a photodetector and locked in the servo-loop. For absolute discrete values of cavity lengths L p that well satisfy the condition above we obtain precise etalons of length.
Wang, Peng; Ying, Shuxuan
2015-01-01
We compute the black hole horizon entanglement entropy for a massless scalar field in the brick wall model by incorporating the minimal length. Taking the minimal length effects on the occupation number $n(\\omega,l)$ and the Hawking temperature into consideration, we obtain the leading UV divergent term and the subleading logarithmic term in the entropy. The leading divergent term scales with the horizon area. The subleading logarithmic term is the same as that in the usual brick wall model without the minimal length.
Thermal control of rod outer segment length and shedding in a fish, Fundulus zebrinus.
Allen, D M
1995-08-01
The effects of temperature on rod outer segment (ROS) length and membrane shedding were studied in a cyprinodont fish, Fundulus zebrinus. After 30 days in 14L/10D cyclic light and 17 degrees C, ROS length averaged 41.2 microns. Fish were then exposed to 7, 17 or 27 degrees C for 10 and 25 days before being sampled 5 hr before and 1-4 hr after light onset. In 7 degrees C ROS shortened to 83.5% of initial controls within 10 days, then only 4.1% further, to 79.4% by day 25 (34.4, 32.7 microns). ROS length did not change significantly in fish remaining at 17 degrees C (39.7 and 40.7 microns at day 10 and 25) or in fish moved to 27 degrees C (41.7 and 41.6 microns). Phagosomes were most numerous in 7 degrees C and least numerous in 17 degrees C, but varied in overall size among the largest phagosomes being more common after light onset. After light onset at day 25, the estimated volume per phagosome was 1.14, 4.73 and 5.75 microns 3 in 7, 17 and 27 degrees C. Total phagosome volume per 100 microns RPE at 27 degrees C was generally double that at 17 degrees C. Apparently, in F. zebrinus, the number of disks shed from ROS is adjusted during thermal acclimation to stabilize ROS length.
Heinen, M.
2014-01-01
A three-dimensional root length density distribution function is introduced that made it possible to compare two empirical uptake models with a more mechanistic uptake model. Adding a compensation component to the more empirical model resulted in predictions of root water uptake distributions
Henry, Bryan R.; Gough, Kathleen M.
1983-01-01
The theoretical basis for the local mode model is reviewed. The model is applied to gas phase overtone spectra of aromatic molecules to investigate both substituent induced CH bond length changes and conformationally inequivalent hydrogens. The dynamic implications of the local mode model are discussed.
Ngoi, Kuan Hoon; Chia, Chin-Hua, E-mail: chia@ukm.edu.my; Zakaria, Sarani [School of Applied Physics, Faculty Science and Technology, University Kebangsaan Malaysia 43600 UKM Bangi, Selangor (Malaysia); Chiu, Wee Siong [Low Dimensional Materials Research Centre, Department of Physics, Faculty of Science, University of Malaya, 50603 Lembah Pantai, Kuala Lumpur (Malaysia)
2015-09-25
We report on the effect of using reducing agents with different chain-length on the synthesis of iron oxide nanoparticles by thermal decomposition of iron (III) acetylacetonate in 1-octadecene. This modification allows us to control the shape of nanoparticles into spherical and cubic iron oxide nanoparticles. The highly monodisperse 14 nm spherical nanoparticles are obtained under 1,2-dodecanediol and average 14 nm edge-length cubic iron oxide nanoparticles are obtained under 1,2-tetradecanediol. The structural characterization such as transmission electron microscope (TEM) and X-ray diffraction (XRD) shows similar properties between two particles with different shapes. The vibrating sample magnetometer (VSM) shows no significant difference between spherical and cubic nanoparticles, which are 36 emu/g and 37 emu/g respectively and superparamagnetic in nature.
Telomere length in prospective and retrospective cancer case-control studies
Pooley, Karen A.; Sandhu, Manjinder S.; Tyrer, Jonathan; Shah, Mitul; Driver, Kristy E.; Luben, Robert N.; Bingham, Sheila A.; Ponder, Bruce A.J.; Pharoah, Paul D.P.; Khaw, Kay-Tee; Easton, Douglas F.; Dunning, Alison M.
2010-01-01
Previous studies have reported that shorter mean telomere length in lymphocytes is associated with increased susceptibility to common diseases of aging, and may be predictive of cancer risk. However, most analyses have examined retrospectively-collected case-control studies. Mean telomere length was measured using high-throughput quantitative Real Time PCR. Blood for DNA extraction was collected after cancer diagnosis in the East Anglian SEARCH Breast (2243 cases, 2181 controls) and SEARCH Colorectal (2249 cases, 2161 controls) studies. Prospective case-control studies were conducted for breast cancer (199 cases) and colorectal cancer (185 cases), nested within the EPIC-Norfolk cohort. Blood has been collected at least 6 months prior to diagnosis, and was matched to DNA from two cancer-free controls per case. In the retrospective, SEARCH studies, the age-adjusted Odds Ratios for shortest (Q4) vs. longest (Q1) quartile of mean telomere length was 15.5 (95%CI 11.6–20.8), p-het=5.7×10−75; with a ‘per quartile’ p-trend=2.1×10−80 for breast cancer, and 2.14 (95%CI 1.77–2.59), p-het=7.3×10−15; with a ‘per quartile’ p-trend=1.8×10−13 for colorectal cancer. In the prospective, EPIC study, the comparable Odds Ratios [Q4 vs. Q1] were 1.58 (95%CI 0.75–3.31), p-het=0.23 for breast cancer, and 1.13 (95%CI 0.54–2.36), p-het=0.75 for colorectal cancer risk. Mean telomere length was shorter in retrospectively-collected cases than in controls but the equivalent association was markedly weaker in the prospective studies. This suggests that telomere shortening largely occurs after diagnosis, and may not, therefore, be of value in cancer prediction. PMID:20395204
Exact Solution of Mutator Model with Linear Fitness and Finite Genome Length
Saakian, David B.
2017-08-01
We considered the infinite population version of the mutator phenomenon in evolutionary dynamics, looking at the uni-directional mutations in the mutator-specific genes and linear selection. We solved exactly the model for the finite genome length case, looking at the quasispecies version of the phenomenon. We calculated the mutator probability both in the statics and dynamics. The exact solution is important for us because the mutator probability depends on the genome length in a highly non-trivial way.
Tranvåg, Eirik Joakim; Ali, Merima; Norheim, Ole Frithjof
2013-07-11
Most studies on health inequalities use average measures, but describing the distribution of health can also provide valuable knowledge. In this paper, we estimate and compare within-group and between-group inequalities in length of life for population groups in Ethiopia in 2000 and 2011. We used data from the 2011 and 2000 Ethiopia Demographic and Health Survey and the Global Burden of Disease study 2010, and the MODMATCH modified logit life table system developed by the World Health Organization to model mortality rates, life expectancy, and length of life for Ethiopian population groups stratified by wealth quintiles, gender and residence. We then estimated and compared within-group and between-group inequality in length of life using the Gini index and absolute length of life inequality. Length of life inequality has decreased and life expectancy has increased for all population groups between 2000 and 2011. Length of life inequality within wealth quintiles is about three times larger than the between-group inequality of 9 years. Total length of life inequality in Ethiopia was 27.6 years in 2011. Longevity has increased and the distribution of health in Ethiopia is more equal in 2011 than 2000, with length of life inequality reduced for all population groups. Still there is considerable potential for further improvement. In the Ethiopian context with a poor and highly rural population, inequality in length of life within wealth quintiles is considerably larger than between them. This suggests that other factors than wealth substantially contribute to total health inequality in Ethiopia and that identification and quantification of these factors will be important for identifying proper measures to further reduce length of life inequality.
ON EVALUATING THE RUN LENGTH PROPERTIES OF X CHARTS WITH ESTIMATED CONTROL LIMITS
LI Guoying; YANG Chunyan; Siu-Keung TSE
2002-01-01
(X)charts with estimated control limits are commonly used in practice andtreated as if the in-control process parameters were known. However, the former canbehave quite differently from the latter. To understand the differences, it is necessary tostudy the run length distribution (RLD), its mean (ARL) and standard deviation (SDRL)of the (X)charts when the control limits are estimated. However, ARL and SDRL areintegrals over an infinite region with a boundless integrand, the finiteness has not beenproved in literature. In this paper, we show the finiteness and uniform integrability ofARL and SDRL. Furthermore, we numerically evaluate the ARL, SDRL and the RLDusing number theory method. A numerical study is conducted to assess the performanceof the proposed method and the results are compared with those given by Quesenberryand Chen.
Moon, Young Kyun; Lee, Jaebeom; Lee, Jae Keun; Kim, Tae Kyu; Kim, Soo H
2009-02-03
A one-step method combining spray pyrolysis and thermal chemical vapor deposition (CVD) processes was developed to grow hybrid carbon nanotube (CNT)-bimetallic composite particles. Nickel, aluminum, and acetylene were used as the catalytic site, noncatalytic matrix, and hydrocarbon source, respectively. The bimetallic particles (i.e., Al-Ni) were spray pyrolized and subsequently passed through thermal CVD. During the thermal CVD, the catalytic decomposition of acetylene occurred on the free-floating bimetallic particles so that sea urchin-like CNTs were radially grown. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses revealed the CNTs to have a uniform diameter of approximately 10 +/- 2 nm. The length of the CNTs was controlled by varying the residence time of the bimetallic nanoparticles with a length of 200-1000 nm. After nitric acid treatment, the CNTs were released by melting the bimetallic particles. The resulting CNTs were then dispersed in an aqueous solution to examine the effect of the length of CNTs on their dispersion stability, which is a critical issue for the stability and repeatability of the heat transfer performance in nanofluids. Ultraviolet-visible (UV-vis) spectrometer analysis showed that shorter CNTs were less stable than the longer CNTs due to the higher mobility-induced agglomeration of the shorter CNTs.
Czepielewski, Leticia Sanguinetti; Massuda, Raffael; Panizzutti, Bruna; da Rosa, Eduarda Dias; de Lucena, David; Macêdo, Danielle; Grun, Lucas Kich; Barbé-Tuana, Florencia María; Gama, Clarissa Severino
2016-07-01
Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n=36), unaffected siblings (SB, n=36) and healthy controls (HC, n=47). SZ had shorter TL compared to HC, but no difference was found in SB comparing to SZ. These findings indicate that a pathological accelerated aging profile could be present in the course of SZ and further studies are needed to confirm TL as potential endophenotype, especially in at risk populations.
Stochastic modeling of length-dependent telomere shortening in Corvus monedula
Grasman, J.; Salomons, H. M.; Verhulst, S.
2011-01-01
It was recently shown that, within individuals, longer telomeres shorten at a higher rate. This explorative study deals with a mathematical model of this process. It is a nonlinear differential equation describing length-dependent decrease that can be linked to a Poisson process. The model also take
Stochastic modelling of length-dependent telomere shortening in Corvus monedula
Grasman, J.; Salomons, H.M.; Verhulst, S.
2011-01-01
It was recently shown that, within individuals, longer telomeres shorten at a higher rate. This explorative study deals with a mathematical model of this process. It is a nonlinear differential equation describing length-dependent decrease that can be linked to a Poisson process. The model also take
Stochastic Control - External Models
Poulsen, Niels Kjølstad
2005-01-01
This note is devoted to control of stochastic systems described in discrete time. We are concerned with external descriptions or transfer function model, where we have a dynamic model for the input output relation only (i.e.. no direct internal information). The methods are based on LTI systems...
Aeroservoelasticity modeling and control
Tewari, Ashish
2015-01-01
This monograph presents the state of the art in aeroservoelastic (ASE) modeling and analysis and develops a systematic theoretical and computational framework for use by researchers and practicing engineers. It is the first book to focus on the mathematical modeling of structural dynamics, unsteady aerodynamics, and control systems to evolve a generic procedure to be applied for ASE synthesis. Existing robust, nonlinear, and adaptive control methodology is applied and extended to some interesting ASE problems, such as transonic flutter and buffet, post-stall buffet and maneuvers, and flapping flexible wing. The author derives a general aeroservoelastic plant via the finite-element structural dynamic model, unsteady aerodynamic models for various regimes in the frequency domain, and the associated state-space model by rational function approximations. For more advanced models, the full-potential, Euler, and Navier-Stokes methods for treating transonic and separated flows are also briefly addressed. Essential A...
Elisha Townshend
2015-09-01
Full Text Available Effective planning to optimize the forest value chain requires accurate and detailed information about the resource; however, estimates of the distribution of fibre properties on the landscape are largely unavailable prior to harvest. Our objective was to fit a model of the tree-level average fibre length related to ecosite classification and other forest inventory variables depicted at the landscape scale. A series of black spruce increment cores were collected at breast height from trees in nine different ecosite groups within the boreal forest of northeastern Ontario, and processed using standard techniques for maceration and fibre length measurement. Regression tree analysis and random forests were used to fit hierarchical classification models and find the most important predictor variables for the response variable area-weighted mean stem-level fibre length. Ecosite group was the best predictor in the regression tree. Longer mean fibre-length was associated with more productive ecosites that supported faster growth. The explanatory power of the model of fitted data was good; however, random forests simulations indicated poor generalizability. These results suggest the potential to develop localized models linking wood fibre length in black spruce to landscape-level attributes, and improve the sustainability of forest management by identifying ideal locations to harvest wood that has desirable fibre characteristics.
Distribution of branch lengths and phylogenetic diversity under homogeneous speciation models
Stadler, Tanja
2011-01-01
The constant rate birth--death process is a popular null model for speciation and extinction. If one removes extinct and non-sampled lineages, this process induces `reconstructed trees' which describe the relationship between extant lineages. We derive the probability density of the length of a randomly chosen pendant edge in a reconstructed tree. For the special case of a pure-birth process with complete sampling, we also provide the probability density of the length of an interior edge, of the length of an edge descending from the root, and of the diversity (which is the sum of all edge lengths). We show that the results depend on whether the reconstructed trees are conditioned on the number of leaves, the age, or both.
Organ Length Control by an ADAMTS Extracellular Protease in Caenorhabditis elegans
Shibata, Yukimasa; Kawakado, Yuri; Hori, Noriyoshi; Tanaka, Kota; Inoue, Ryo; Takano, Tomomi; Kubota, Yukihiko; Nishiwaki, Kiyoji
2016-01-01
MIG-17, a secreted protease of the ADAMTS family, acts in the directed migration of gonadal distal tip cells (DTCs) through regulation of the gonadal basement membrane in Caenorhabditis elegans. Here, we show that MIG-17 is also required for the control of pharynx elongation during animal growth. We found that the pharynx was elongated in mig-17 mutants compared with wild type. MIG-17 localized to the pharyngeal basement membrane as well as to the gonadal basement membrane. The number of nuclei in the pharynx, and the pumping rate of the pharynx, were not affected in mig-17 mutants, suggesting that cells constituting the pharynx are elongated, although the pharynx functions normally in these mutants. In contrast to the control of DTC migration, MIG-18, a secreted cofactor of MIG-17, was not essential for pharynx length regulation. In addition, the downstream pathways of MIG-17 involving LET-2/type IV collagen, FBL-1/fibulin-1, and NID-1/nidogen, partly diverged from those in gonad development. These results indicate that basement membrane remodeling is important for organ length regulation, and suggest that MIG-17/ADAMTS functions in similar but distinct molecular machineries in pharyngeal and gonadal basement membranes. PMID:26994289
Gräf, Christian; Vahlbruch, Henning; Danzmann, Karsten; Schnabel, Roman
2012-01-01
The techniques of power recycling and signal recycling have proven as key concepts to increase the sensitivity of large-scale gravitational wave detectors by independent resonant enhancement of light power and signal sidebands within the interferometer. Developing the latter concept further, twin signal recycling was proposed as an alternative to conventional detuned signal recycling. Twin signal recycling features the narrow-band sensitivity gain of conventional detuned signal recycling but furthermore facilitates the injection of squeezed states of light, increases the detector sensitivity over a wide frequency band and requires a less complex detection scheme for optimal signal readout. These benefits come at the expense of an additional recycling mirror, thus increasing the number of degrees of freedom in the interferometer which need to be controlled. In this article we describe the development of a length sensing and control scheme and its successful application to a tabletop-scale power recycled Michel...
Schofield, Matthew R; Barker, Richard J; Taylor, Peter
2013-12-01
We use Bayesian methods to explore fitting the von Bertalanffy length model to tag-recapture data. We consider two popular parameterizations of the von Bertalanffy model. The first models the data relative to age at first capture; the second models in terms of length at first capture. Using data from a rainbow trout Oncorhynchus mykiss study we explore the relationship between the assumptions and resulting inference using posterior predictive checking, cross validation and a simulation study. We find that untestable hierarchical assumptions placed on the nuisance parameters in each model can influence the resulting inference about parameters of interest. Researchers should carefully consider these assumptions when modeling growth from tag-recapture data. © 2013, The International Biometric Society.
Fliess, Michel; Join, Cédric
2013-12-01
'Model-free control'and the corresponding 'intelligent' PID controllers (iPIDs), which already had many successful concrete applications, are presented here for the first time in an unified manner, where the new advances are taken into account. The basics of model-free control is now employing some old functional analysis and some elementary differential algebra. The estimation techniques become quite straightforward via a recent online parameter identification approach. The importance of iPIs and especially of iPs is deduced from the presence of friction. The strange industrial ubiquity of classic PIDs and the great difficulty for tuning them in complex situations is deduced, via an elementary sampling, from their connections with iPIDs. Several numerical simulations are presented which include some infinite-dimensional systems. They demonstrate not only the power of our intelligent controllers but also the great simplicity for tuning them.
Naqshband, Suleyman; McElroy, Brandon; Mahon, Robert C.
2017-05-01
The mechanics of sediment transport are of fundamental importance for fluvio-deltaic morphodynamics. The present study focuses on quantifying particle motions and trajectories across a wide range of flow conditions. In particular, a continuous model is presented that predicts particle travel distances for saltation and suspension based on Rouse number and relative grain roughness. By utilizing a series of eight video cameras in a plexiglass flume direct measurements of the distributions of particle travel distances (excursion lengths) were obtained. To this end, experiments were carried out in dark under black lights with fluorescent painted plastic and quartz sand particles. For relatively high Rouse numbers indicating bed load dominant transport regime (P≥2.5), particle motion is governed by the effect of gravitational forces (settling velocities) and measured excursion lengths closely follow a Gaussian distribution. For P=2.5, particle motion is equally subjected to both gravitational and turbulent forces. Consequently, measured excursion lengths exhibit a bimodal distribution with two distinct peaks. As turbulent fluctuations increase and dominate particle motion over gravity (P(P=1.8-8.9). Furthermore, measured excursion lengths are observed to fit within the predicted range of excursion lengths with no significant difference between measured excursion lengths of plastic and quartz sand particles.
Parente, Lorena Arruda; Levin, Martin D; Vivan, Rodrigo Ricci; Bernardes, Ricardo Affonso; Duarte, Marco Antonio Hungaro; Vasconcelos, Bruno Carvalho de
2015-10-01
The present study evaluated the efficacy of electronic foramen locators (EFLs) to control root canal working length during rotary instrumentation and to assess possible reliability variations of different working lengths. Forty-eight human mandibular bicuspids were randomly divided in 2 groups according to the used device, Root ZX II (RZX) and Propex II (PRO). They were further subdivided in 2 subgroups according to the root canal preparation level (0.0 and -1.0). Preparation was performed with the Protaper rotary system using a crown-down technique. RZX was employed on its automatic auto-reverse mode (AAR) and PRO was used with the MPAS-10R contra-angle to monitor the preparation. The last used file (F3) was fixed, and the apical portion of the teeth was worn buccolingually, allowing to measure the extent between the file tip and the apical foramen (AF). The precision values of 0.0 mm and -1.0 mm were 100% and 0.0% for RZX, and 100% and 66.7% for PRO, respectively, with a range of ±0.5 mm. Statistical analysis showed no differences between the groups at 0.0 mm. However, at -1.0 mm, RZX showed the poorest results (0.96±0.11 mm), followed by PRO (0.43±0.23 mm). The difference between RZX and PRO was statistically significant. The EFLs were precise in maintaining the working length during rotary preparation when reaching the AF, but when their penetration was limited, both devices showed decreased precision; the RZX AAR failed in all instances.
Troynikov, V S; Gorfine, H K; Ložys, L; Pūtys, Z; Jakubavičiūtė, E; Day, R W
2011-12-01
Three stochastic versions of the Gompertz growth model were used to parameterize total length (L(T) )-at-age data for perch Perca fluviatilis, an important target species for commercial and recreational fishers and a food species for predatory fishes and aquatic birds. Each model addresses growth heterogeneity by incorporating random parameters from a specific positive distribution: Weibull, gamma or log-normal. The modelling outputs for each version of the model provide L(T) distributions for selected ages and percentiles of L(T) at age for both males and females. The results highlight the importance of using a stochastic approach and the logistic-like growth pattern for analysing growth data for P. fluviatilis in Curonian Lagoon (Lithuania). Outputs from this modelling can be extended to a stochastic analysis of fish cohort dynamics, incorporating all length-based biological relationships, and the selectivity-related interactions between fish cohorts and fishing gear.
Earth Data Analysis Center, University of New Mexico — Flame length was modeled using FlamMap, an interagency fire behavior mapping and analysis program that computes potential fire behavior characteristics. The tool...
Effect of calibration data length on performance and optimal parameters of hydrological model
Chuan-Zhe LI
2010-12-01
Full Text Available In order to assess the effects of calibration data length on the performance and optimal parameter values of hydrological model in ungauged or data limited catchments (actually, data are non-continuous and fragmental in some catchments, we choose to use non-continuous calibration periods to have more independent streamflow data for SIMHYD model calibration. Nash-Sutcliffe efficiency (NSE and percentage water balance error (WBE are used as performance measures. The Particle Swarm Optimization (PSO method is used to calibrate the rainfall-runoff models. Different length of data range from 1 year to 10 years randomly sampled used for study on impact of calibration data length. 55 relatively unimpaired catchments all over Australia with daily precipitation, potential evapotranspiration (PET, and streamflow data are tested to obtain more general conclusions. The results show that, longer calibration data does not necessarily result in better model performance. In general, 8 years data are sufficient to obtain steady estimates of model performance and parameters for SIMHYD model. It is also show that most humid catchments require fewer calibration data to get good performance and stable parameter values. The model performs better in humid and semi-humid catchments than arid catchments. Our results may have useful and interesting implications in the efficiency of limited observation data used for hydrological model calibration in different climatic catchments.
Aniek van der Vaart
2015-12-01
Full Text Available Cilia are sensory organelles present on almost all vertebrate cells. Cilium length is constant, but varies between cell types, indicating that cilium length is regulated. How this is achieved is unclear, but protein transport in cilia (intraflagellar transport, IFT plays an important role. Several studies indicate that cilium length and function can be modulated by environmental cues. As a model, we study a C. elegans mutant that carries a dominant active G protein α subunit (gpa-3QL, resulting in altered IFT and short cilia. In a screen for suppressors of the gpa-3QL short cilium phenotype, we identified uev-3, which encodes an E2 ubiquitin-conjugating enzyme variant that acts in a MAP kinase pathway. Mutation of two other components of this pathway, dual leucine zipper-bearing MAPKKK DLK-1 and p38 MAPK PMK-3, also suppress the gpa-3QL short cilium phenotype. However, this suppression seems not to be caused by changes in IFT. The DLK-1/p38 pathway regulates several processes, including microtubule stability and endocytosis. We found that reducing endocytosis by mutating rabx-5 or rme-6, RAB-5 GEFs, or the clathrin heavy chain, suppresses gpa-3QL. In addition, gpa-3QL animals showed reduced levels of two GFP-tagged proteins involved in endocytosis, RAB-5 and DPY-23, whereas pmk-3 mutant animals showed accumulation of GFP-tagged RAB-5. Together our results reveal a new role for the DLK-1/p38 MAPK pathway in control of cilium length by regulating RAB-5 mediated endocytosis.
van der Vaart, Aniek; Rademakers, Suzanne; Jansen, Gert
2015-12-01
Cilia are sensory organelles present on almost all vertebrate cells. Cilium length is constant, but varies between cell types, indicating that cilium length is regulated. How this is achieved is unclear, but protein transport in cilia (intraflagellar transport, IFT) plays an important role. Several studies indicate that cilium length and function can be modulated by environmental cues. As a model, we study a C. elegans mutant that carries a dominant active G protein α subunit (gpa-3QL), resulting in altered IFT and short cilia. In a screen for suppressors of the gpa-3QL short cilium phenotype, we identified uev-3, which encodes an E2 ubiquitin-conjugating enzyme variant that acts in a MAP kinase pathway. Mutation of two other components of this pathway, dual leucine zipper-bearing MAPKKK DLK-1 and p38 MAPK PMK-3, also suppress the gpa-3QL short cilium phenotype. However, this suppression seems not to be caused by changes in IFT. The DLK-1/p38 pathway regulates several processes, including microtubule stability and endocytosis. We found that reducing endocytosis by mutating rabx-5 or rme-6, RAB-5 GEFs, or the clathrin heavy chain, suppresses gpa-3QL. In addition, gpa-3QL animals showed reduced levels of two GFP-tagged proteins involved in endocytosis, RAB-5 and DPY-23, whereas pmk-3 mutant animals showed accumulation of GFP-tagged RAB-5. Together our results reveal a new role for the DLK-1/p38 MAPK pathway in control of cilium length by regulating RAB-5 mediated endocytosis.
Kalaitzaki, Eleftheria; White, Ian R; Khadjesari, Zarnie; Murray, Elizabeth; Linke, Stuart; Thompson, Simon G; Godfrey, Christine; Wallace, Paul
2011-01-01
Background There has been limited study of factors influencing response rates and attrition in online research. Online experiments were nested within the pilot (study 1, n = 3780) and main trial (study 2, n = 2667) phases of an evaluation of a Web-based intervention for hazardous drinkers: the Down Your Drink randomized controlled trial (DYD-RCT). Objectives The objective was to determine whether differences in the length and relevance of questionnaires can impact upon loss to follow-up in online trials. Methods A randomized controlled trial design was used. All participants who consented to enter DYD-RCT and completed the primary outcome questionnaires were randomized to complete one of four secondary outcome questionnaires at baseline and at follow-up. These questionnaires varied in length (additional 23 or 34 versus 10 items) and relevance (alcohol problems versus mental health). The outcome measure was the proportion of participants who completed follow-up at each of two follow-up intervals: study 1 after 1 and 3 months and study 2 after 3 and 12 months. Results At all four follow-up intervals there were no significant effects of additional questionnaire length on follow-up. Randomization to the less relevant questionnaire resulted in significantly lower rates of follow-up in two of the four assessments made (absolute difference of 4%, 95% confidence interval [CI] 0%-8%, in both study 1 after 1 month and in study 2 after 12 months). A post hoc pooled analysis across all four follow-up intervals found this effect of marginal statistical significance (unadjusted difference, 3%, range 1%-5%, P = .01; difference adjusted for prespecified covariates, 3%, range 0%-5%, P = .05). Conclusions Apparently minor differences in study design decisions may have a measurable impact on attrition in trials. Further investigation is warranted of the impact of the relevance of outcome measures on follow-up rates and, more broadly, of the consequences of what we ask participants to
Interferometric length metrology for the dimensional control of ultra-stable Ring Laser Gyroscopes
Belfi, J; Cuccato, D; Di Virgilio, A; Maccioni, E; Ortolan, A; Santagata, R
2014-01-01
We present the experimental test of a method for controlling the absolute length of the diagonals of square ring laser gyroscopes. The purpose is to actively stabilize the ring cavity geometry and to enhance the rotation sensor stability in order to reach the requirements for the detection of the relativistic Lense-Thirring effect with a ground-based array of optical gyroscopes. The test apparatus consists of two optical cavities 1.32 m in length, reproducing the features of the ring cavity diagonal resonators of large frame He-Ne ring laser gyroscopes. The proposed measurement technique is based on the use of a single diode laser, injection locked to a frequency stabilized He-Ne/Iodine frequency standard, and a single electro-optic modulator. The laser is modulated with a combination of three frequencies allowing to lock the two cavities to the same resonance frequency and, at the same time, to determine the cavity Free Spectral Range (FSR). We obtain a stable lock of the two cavities to the same optical fre...
CFD modeling using PDF approach for investigating the flame length in rotary kilns
Elattar, H. F.; Specht, E.; Fouda, A.; Bin-Mahfouz, Abdullah S.
2016-12-01
Numerical simulations using computational fluid dynamics (CFD) are performed to investigate the flame length characteristics in rotary kilns using probability density function (PDF) approach. A commercial CFD package (ANSYS-Fluent) is employed for this objective. A 2-D axisymmetric model is applied to study the effect of both operating and geometric parameters of rotary kiln on the characteristics of the flame length. Three types of gaseous fuel are used in the present work; methane (CH4), carbon monoxide (CO) and biogas (50 % CH4 + 50 % CO2). Preliminary comparison study of 2-D modeling outputs of free jet flames with available experimental data is carried out to choose and validate the proper turbulence model for the present numerical simulations. The results showed that the excess air number, diameter of kiln air entrance, radiation modeling consideration and fuel type have remarkable effects on the flame length characteristics. Numerical correlations for the rotary kiln flame length are presented in terms of the studied kiln operating and geometric parameters within acceptable error.
Comparing mixing-length models of the diabatic wind profile over homogeneous terrain
Pena Diaz, Alfredo; Gryning, Sven-Erik; Hasager, Charlotte Bay
2010-01-01
Models of the diabatic wind profile over homogeneous terrain for the entire atmospheric boundary layer are developed using mixing-length theory and are compared to wind speed observations up to 300 m at the National Test Station for Wind Turbines at Høvsøre, Denmark. The measurements are performed...
CFD modeling using PDF approach for investigating the flame length in rotary kilns
Elattar, H. F.; Specht, E.; Fouda, A.; Bin-Mahfouz, Abdullah S.
2016-02-01
Numerical simulations using computational fluid dynamics (CFD) are performed to investigate the flame length characteristics in rotary kilns using probability density function (PDF) approach. A commercial CFD package (ANSYS-Fluent) is employed for this objective. A 2-D axisymmetric model is applied to study the effect of both operating and geometric parameters of rotary kiln on the characteristics of the flame length. Three types of gaseous fuel are used in the present work; methane (CH4), carbon monoxide (CO) and biogas (50 % CH4 + 50 % CO2). Preliminary comparison study of 2-D modeling outputs of free jet flames with available experimental data is carried out to choose and validate the proper turbulence model for the present numerical simulations. The results showed that the excess air number, diameter of kiln air entrance, radiation modeling consideration and fuel type have remarkable effects on the flame length characteristics. Numerical correlations for the rotary kiln flame length are presented in terms of the studied kiln operating and geometric parameters within acceptable error.
A Short Introduction to Model Selection, Kolmogorov Complexity and Minimum Description Length (MDL)
Nannen, Volker
2010-01-01
The concept of overtting in model selection is explained and demon- strated. After providing some background information on information theory and Kolmogorov complexity, we provide a short explanation of Minimum Description Length and error minimization. We conclude with a discussion of the typical
Charnock's Roughness Length Model and Non-dimensional Wind Profiles Over the Sea
Pena Diaz, Alfredo; Gryning, Sven-Erik
2008-01-01
An analysis tool for the study of wind speed profiles over the water has been developed. The profiles are analysed using a modified dimensionless wind speed and dimensionless height, assuming that the sea surface roughness can be predicted by Charnock's roughness length model. In this form, the r...
Modeling the Effects of Argument Length and Validity on Inductive and Deductive Reasoning
Rotello, Caren M.; Heit, Evan
2009-01-01
In an effort to assess models of inductive reasoning and deductive reasoning, the authors, in 3 experiments, examined the effects of argument length and logical validity on evaluation of arguments. In Experiments 1a and 1b, participants were given either induction or deduction instructions for a common set of stimuli. Two distinct effects were…
Kranenburg, C.
1999-01-01
The Prandtl mixing-length model of turbulent exchange of mass and momentum is applied to calculate the entrainment of overlying water into a layer of suspended fine sediment at a horizontal bed. In the field the flow and turbulence in such a concentrated benthic suspension (CBS) are driven by a
MODEL PREDICTIVE CONTROL FUNDAMENTALS
2012-07-02
Jul 2, 2012 ... paper, we will present an introduction to the theory and application of MPC with Matlab codes written to ... model predictive control, linear systems, discrete-time systems, ... and then compute very rapidly for this open-loop con-.
Olsen Morten
2012-09-01
Full Text Available Abstract Background Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent critique for being too error-prone and yielding unreliable results. This critique coincides with an increasing awareness of the potentials and limitations of the qPCR technique in general and the proposal of a general set of guidelines (MIQE for standardization of experimental, analytical, and reporting steps of qPCR. In order to evaluate the utility of the qPCR method for telomere length estimation in non-model species, we carried out four different qPCR assays directed at humpback whale telomeres, and subsequently performed a rigorous quality control to evaluate the performance of each assay. Results Performance differed substantially among assays and only one assay was found useful for telomere length estimation in humpback whales. The most notable factors causing these inter-assay differences were primer design and choice of using singleplex or multiplex assays. Inferred amplification efficiencies differed by up to 40% depending on assay and quantification method, however this variation only affected telomere length estimates in the worst performing assays. Conclusion Our results suggest that seemingly well performing qPCR assays may contain biases that will only be detected by extensive quality control. Moreover, we show that the qPCR method for telomere length estimation can be highly precise and accurate, and thus suitable for telomere measurement in non-model species, if effort is devoted to optimization at all experimental and analytical steps. We conclude by highlighting a set of quality controls which may serve for further standardization of the qPCR method for telomere length estimation, and discuss some of the factors that may cause
Rac1 controls epithelial tube length through the apical secretion and polarity pathways
Kévin Sollier
2016-01-01
Full Text Available The morphometric parameters of epithelial tubes are critical to the physiology and homeostasis of most organs. In addition, many human diseases are associated with tube-size defects. Here, we show that Rac1 limits epithelial tube elongation in the developing fly trachea by promoting Rab5-dependent endocytosis of the apical determinant Crumbs. Rac1 is also involved in a positive feedback loop with the septate junction protein Coracle. Thereby, Rac1 precludes paracellular diffusion and contributes to the septate junction-dependent secretion of the chitin-modifying enzymes Vermiform and Serpentine, which restrict epithelial tube length independently of Crumbs. Thus, Rac1 is a critical component of two important pathways controlling epithelial tube morphogenesis.
Rac1 controls epithelial tube length through the apical secretion and polarity pathways
Sollier, Kévin; Gaudé, Helori-Mael; Chartier, François J.-M.; Laprise, Patrick
2016-01-01
ABSTRACT The morphometric parameters of epithelial tubes are critical to the physiology and homeostasis of most organs. In addition, many human diseases are associated with tube-size defects. Here, we show that Rac1 limits epithelial tube elongation in the developing fly trachea by promoting Rab5-dependent endocytosis of the apical determinant Crumbs. Rac1 is also involved in a positive feedback loop with the septate junction protein Coracle. Thereby, Rac1 precludes paracellular diffusion and contributes to the septate junction-dependent secretion of the chitin-modifying enzymes Vermiform and Serpentine, which restrict epithelial tube length independently of Crumbs. Thus, Rac1 is a critical component of two important pathways controlling epithelial tube morphogenesis. PMID:26700724
Masai, Hiroshi; Terao, Jun; Fujihara, Tetsuaki; Tsuji, Yasushi
2016-05-01
We describe a new concept for rotaxane synthesis through intramolecular slippage using π-conjugated molecules as rigid axles linked with organic soluble and flexible permethylated α-cyclodextrins (PM α-CDs) as macrocycles. Through hydrophilic-hydrophobic interactions and flipping of PM α-CDs, successful quantitative conversion into rotaxanes was achieved without covalent bond formation. The rotaxanes had high activation barrier for their de-threading, so that they were kinetically isolated and derivatized even under conditions unfavorable for maintaining the rotaxane structures. (1) H NMR spectroscopy experiments clearly revealed that the restricted motion of the linked macrocycle with the rigid axle made it possible to control the kinetic stability by adjusting the length of the rigid axle in the precursor structure rather than the steric bulkiness of the stopper unit.
Modelling, controlling, predicting blackouts
Wang, Chengwei; Baptista, Murilo S
2016-01-01
The electric power system is one of the cornerstones of modern society. One of its most serious malfunctions is the blackout, a catastrophic event that may disrupt a substantial portion of the system, playing havoc to human life and causing great economic losses. Thus, understanding the mechanisms leading to blackouts and creating a reliable and resilient power grid has been a major issue, attracting the attention of scientists, engineers and stakeholders. In this paper, we study the blackout problem in power grids by considering a practical phase-oscillator model. This model allows one to simultaneously consider different types of power sources (e.g., traditional AC power plants and renewable power sources connected by DC/AC inverters) and different types of loads (e.g., consumers connected to distribution networks and consumers directly connected to power plants). We propose two new control strategies based on our model, one for traditional power grids, and another one for smart grids. The control strategie...
A Generic Length-scale Equation For Second-order Turbulence Models of Oceanic Boundary Layers
Umlauf, L.; Burchard, H.
A generic transport equation for a generalized length-scale in second-order turbulence closure models for geophysical boundary layers is suggested. This variable consists of the products of powers of the turbulent kinetic energy, k, and the integral length-scale, l. The new approach generalizes traditional second-order models used in geophysical boundary layer modelling, e.g. the Mellor-Yamada model and the k- model, which, however, can be recovered as special cases. It is demonstrated how this new model can be calibrated with measurements in some typical geophysical boundary layer flows. As an example, the generic model is applied to the uppermost oceanic boundary layer directly influenced by the effects of breaking surface waves. Recent measurements show that in this layer the classical law of the wall is invalid, since there turbulence is dominated by turbulent transport of TKE from above, and not by shear-production. A widely accepted approach to describe the wave-affected layer with a one-equation turbulence model was suggested by Craig and Banner (1994). Here, some deficien- cies of their solutions are pointed out and a generalization of their ideas for the case of two-equation models is suggested. Direct comparison with very recently obtained measurements of the dissipation rate, , in the wave-affected boundary layer with com- puted results clearly demonstrate that only the generic two-equation model yields cor- rect predictions for the profiles of and the turbulent length scale, l. Also, the pre- dicted velocity profiles in the wave-affected layer, important e.g. for the interpretation of surface drifter experiments, are reproduced correctly only by the generic model. Implementation and computational costs of the generic model are comparable with traditonal two-equation models.
Haasenritter, Jörg; Eisenschink, Anna Maria; Kirchner, Elisabeth; Bauder-Missbach, Heidi; Brach, Michael; Veith, Jessica; Sander, Silvia; Panfil, Eva-Maria
2009-02-01
A medial incision is a common surgical technique to obtain access to the abdomen. Thereby, the muscles involved in movement are manipulated, leading to post-operative restrictions in mobility and pain determined by movement. The aim of this pilot study was to assess the impact of a pre-operative training session using the Viv-Arte model, which is based on kinesthetic mobilisation principles. The parameters to be measured were mobility, pain, and length of hospital stay for patients, who were undergoing elective medial laparotomy. In addition, the study tested the research design and to identify possible effect sizes. The method chosen was a prospective, randomised, controlled, and unblinded design. Twenty-seven patients were involved (median=63 years, 19 of the patients were male) who were to have a medial incision for cystectomy. The intervention involved pre-operative training of post-operative mobility techniques. Mobility was tested using the "Mobilitätstest für Patienten im Akutkrankenhaus (MOTPA) (Mobility test for patients in hospital)"; pain intensity was assessed using the visual analogue scale. The intervention and control groups were comparable for all variables. There were no significant differences in the two groups related to the objectives. It is possible that the study groups or the operationalisation were not appropriate for testing the effects of the intervention. It seems important to continue to develop instruments that are appropriate for measuring the effect of mobility-related interventions.
Infrared length scale and extrapolations for the no-core shell model
Wendt, K A; Papenbrock, T; Sääf, D
2015-01-01
We precisely determine the infrared (IR) length scale of the no-core shell model (NCSM). In the NCSM, the $A$-body Hilbert space is truncated by the total energy, and the IR length can be determined by equating the intrinsic kinetic energy of $A$ nucleons in the NCSM space to that of $A$ nucleons in a $3(A-1)$-dimensional hyper-radial well with a Dirichlet boundary condition for the hyper radius. We demonstrate that this procedure indeed yields a very precise IR length by performing large-scale NCSM calculations for $^{6}$Li. We apply our result and perform accurate IR extrapolations for bound states of $^{4}$He, $^{6}$He, $^{6}$Li, $^{7}$Li. We also attempt to extrapolate NCSM results for $^{10}$B and $^{16}$O with bare interactions from chiral effective field theory over tens of MeV.
Mohammed Ashraf; Franck Chollet; Murukeshan Matham; Chun Yang
2009-08-01
Thermal reﬂow of polymer to generate spherical proﬁle has been used to fabricate microlenses in this paper. A simple model based on the volume conservation (before and after reﬂow) and geometrical consideration of lens proﬁle, shows that the focal length of the microlens produced by reﬂow technique is a function of the initial geometry of microcylinders, i.e. diameter and thickness. This relationship of focal length with diameter and thickness is used as a basis to control focal length. A simple spin coating technique on dual surface is used to achieve differential thickness, to control the focal length of microlenses produced on the same substrate. A biomedical application of such combination of microlenses is endoscopy where the lenses of varying diameter and equal focal length are needed on top of optical ﬁbre bundles to provide independent function of illumination and imaging. This paper incorporates the differential thickness technique to show a micro fabrication process to produce the polymer reﬂowed microlenses, with a control of focal length based on thickness. The design also helps to integrate these microlenses on top an optical ﬁbre with accurate alignment.
Srivastava, Priyaka; Kraus, Jeff; Murawski, Robert; Golden, Bertsel, Jr.
2015-01-01
NASAs Space Communications and Navigation (SCaN) program manages three active networks: the Near Earth Network, the Space Network, and the Deep Space Network. These networks simultaneously support NASA missions and provide communications services to customers worldwide. To efficiently manage these resources and their capabilities, a team of student interns at the NASA Glenn Research Center is developing a distributed system to model the SCaN networks. Once complete, the system shall provide a platform that enables users to perform capacity modeling of current and prospective missions with finer-grained control of information between several simulation and modeling tools. This will enable the SCaN program to access a holistic view of its networks and simulate the effects of modifications in order to provide NASA with decisional information. The development of this capacity modeling system is managed by NASAs Strategic Center for Education, Networking, Integration, and Communication (SCENIC). Three primary third-party software tools offer their unique abilities in different stages of the simulation process. MagicDraw provides UMLSysML modeling, AGIs Systems Tool Kit simulates the physical transmission parameters and de-conflicts scheduled communication, and Riverbed Modeler (formerly OPNET) simulates communication protocols and packet-based networking. SCENIC developers are building custom software extensions to integrate these components in an end-to-end space communications modeling platform. A central control module acts as the hub for report-based messaging between client wrappers. Backend databases provide information related to mission parameters and ground station configurations, while the end user defines scenario-specific attributes for the model. The eight SCENIC interns are working under the direction of their mentors to complete an initial version of this capacity modeling system during the summer of 2015. The intern team is composed of four students in
Zou, Jing; Xu, Xingxiang; Wang, Daxin; Xu, Jin; Gu, Wenju
2015-05-01
To explore the impacts of the multidisciplinary team model on the average length of stay and hospital expenses of patients with lung cancer. After the multidisciplinary team discussion, 97 patients with lung cancer were selected as the lung cancer group according to the enrollment and elimination criteria the control group was 97 patients with lung cancer managed without team discussion during the same period. All the patients were firstly diagnosed to have lung cancer from December 2011 to December 2013 in Subei People's Hospital. The length of stay, hospital expenses, stages of tumor, types of tumor, Zubrod-ECOG-WHO score, the form of payment, smoking history, sex and age of all the patients were collected. The difference in the average length of stay and hospital expenses between the 2 groups and the associated factors were analyzed by using χ² test, t test and multi-factor stepwise regression analysis. There were 68 males and 29 females with a mean age of (61 ± 9) years in the lung cancer group, while there were 73 males and 24 females with a mean age of (63 ± 10) years in the control group. There were no differences between the 2 groups in tumor staging, tumor types, Zubrod-ECOG-WHO score, the form of payment, smoking history, sex and age (χ² = 4.854, P = 0.563, χ² = 4.248, P = 0.097; χ² = 0.395, P = 0.821; χ² = 1.191, P = 0.554; χ² = 0.108, P = 0.977; χ² = 1.011, P = 0.389; χ² = 0.649, P = 0.519; P = 0.474, P = 0.845, respectively). The average hospital expenses (13 303 vs 16 553, Yuan) were lower and the length of stay (10.33 vs 12.49, days) was shorter in the lung cancer group as compared to the control group (t = 2.616, P = 0.010; t = 2.730, P = 0.007), especially so for the first clinical hospitalization (15 953 vs 19 485 yuan, t = 2.315, P = 0.022; 12.71 vs 14.75 days, t = 1.979, P = 0.049). The average length of stay and the tumor stages were the main factors associated with the average hospital expenses. Except for patients with the
Half-length model of a Siberian Snake magnet for RHIC
Okamura, M; Kawaguchi, T; Katayama, T; Jain, A; Muratore, J; Morgan, G; Willen, E
2000-01-01
For the Relativistic Heavy Ion Collider (RHIC) Spin Project, super-conducting helical dipole magnets are being constructed. These magnets will be used in 'Siberian Snakes' and 'Spin Rotators', which manipulate spin direction of proton beams in RHIC. The dipole field in these magnets rotates 360 deg. and is required to reach a magnetic field strength of more than 4.0 T. The bore radius of the coils and the magnetic length of the magnets are 50 and 2400 mm, respectively. To ascertain the performance of these magnets, which are built using a new 'coil in a slot' technique, a half-length model has been fabricated and tested. The quench performance, field uniformity and rotation angle have been investigated. The measured values in the model magnet agreed well with field calculations. These results demonstrate the adequacy of the fabrication method adopted in the model magnet. (authors)
Jamshidian, M., E-mail: mostafa.jamshidian@gmail.com [Department of Mechanical Engineering, Isfahan University of Technology, Isfahan (Iran, Islamic Republic of); Institute of Structural Mechanics, Bauhaus-University Weimar, Marienstrasse 15, 99423 Weimar (Germany); Rabczuk, T., E-mail: timon.rabczuk@uni-weimar.de [Institute of Structural Mechanics, Bauhaus-University Weimar, Marienstrasse 15, 99423 Weimar (Germany); School of Civil, Environmental and Architectural Engineering, Korea University, Seoul (Korea, Republic of)
2014-03-15
We establish the correlation between the diffuse interface and sharp interface descriptions for stressed grain boundary migration by presenting analytical solutions for stressed migration of a circular grain boundary in a bicrystalline phase field domain. The validity and accuracy of the phase field model is investigated by comparing the phase field simulation results against analytical solutions. The phase field model can reproduce precise boundary kinetics and stress evolution provided that a thermodynamically consistent theory and proper expressions for model parameters in terms of physical material properties are employed. Quantitative phase field simulations are then employed to investigate the effect of microstructural length scale on microstructure and texture evolution by stressed grain growth in an elastically deformed polycrystalline aggregate. The simulation results reveal a transitional behaviour from normal to abnormal grain growth by increasing the microstructural length scale.
Application of nonlocal models to nano beams. Part I: Axial length scale effect.
Kim, Jun-Sik
2014-10-01
Applicability of nonlocal models to nano-beams is discussed in terms of physical implications via the similarity between a nonlocal Euler-Bernoulli (EB) beam theory and a classical Rankine-Timoshenko (RT) beam theory. The nonlocal EB beam model, Eringen's model, is briefly reviewed and the classical RT beam theory is recast by the primary variables of the EB model. A careful comparison of these two models reveals that the scale parameter used to the Eringen's model has a strike resemblance to the shear flexibility in the RT model. This implies that the nonlocal model employed in literature consider the axial length scale effect only. In addition, the paradox for a cantilevered nano-beam subjected to tip shear force is clearly explained by finding appropriate displacement prescribed boundary conditions.
Olsen, Morten Tange; Berube, Martine; Robbins, Jooke
2012-01-01
BACKGROUND:Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent...... critique for being too error-prone and yielding unreliable results. This critique coincides with an increasing awareness of the potentials and limitations of the qPCR technique in general and the proposal of a general set of guidelines (MIQE) for standardization of experimental, analytical, and reporting...... steps of qPCR. In order to evaluate the utility of the qPCR method for telomere length estimation in non-model species, we carried out four different qPCR assays directed at humpback whale telomeres, and subsequently performed a rigorous quality control to evaluate the performance of each assay. RESULTS...
Gräf, Christian; Thüring, André; Vahlbruch, Henning; Danzmann, Karsten; Schnabel, Roman
2013-03-11
The techniques of power recycling and signal recycling have proven as key concepts to increase the sensitivity of large-scale gravitational wave detectors by independent resonant enhancement of light power and signal sidebands within the interferometer. Developing the latter concept further, twin signal recycling was proposed as an alternative to conventional detuned signal recycling. Twin signal recycling features the narrow-band sensitivity gain of conventional detuned signal recycling but furthermore facilitates the injection of squeezed states of light, increases the detector sensitivity over a wide frequency band and requires a less complex detection scheme for optimal signal readout. These benefits come at the expense of an additional recycling mirror, thus increasing the number of degrees of freedom in the interferometer which need to be controlled.In this article we describe the development of a length sensing and control scheme and its successful application to a tabletop-scale power recycled Michelson interferometer with twin signal recycling. We were able to lock the interferometer in all relevant longitudinal degrees of freedom and thus laid the foundation for further investigations of this interferometer configuration to evaluate its viability for the application in gravitational wave detectors.
A new model predicting locomotor cost from limb length via force production.
Pontzer, Herman
2005-04-01
Notably absent from the existing literature is an explicit biomechanical model linking limb design to the energy cost of locomotion, COL. Here, I present a simple model that predicts the rate of force production necessary to support the body and swing the limb during walking and running as a function of speed, limb length, limb proportion, excursion angle and stride frequency. The estimated rate of force production is then used to predict COL via this model following previous studies that have linked COL to force production. To test this model, oxygen consumption and kinematics were measured in nine human subjects while walking and running on a treadmill at range of speeds. Following the model, limb length, speed, excursion angle and stride frequency were used to predict the rate of force production both to support the body's center of mass and to swing the limb. Model-predicted COL was significantly correlated with observed COL, performing as well or better than contact time and Froude number as a predictor of COL for running and walking, respectively. Furthermore, the model presented here predicts relationships between COL, kinematic variables and body size that are supported by published reduced-gravity experiments and scaling studies. Results suggest the model is useful for predicting COL from anatomical and kinematic variables, and may be useful in intra- and inter-specific studies of locomotor anatomy and performance.
Modeling the average shortest-path length in growth of word-adjacency networks
Kulig, Andrzej; DroŻdŻ, Stanisław; Kwapień, Jarosław; OświÈ©cimka, Paweł
2015-03-01
We investigate properties of evolving linguistic networks defined by the word-adjacency relation. Such networks belong to the category of networks with accelerated growth but their shortest-path length appears to reveal the network size dependence of different functional form than the ones known so far. We thus compare the networks created from literary texts with their artificial substitutes based on different variants of the Dorogovtsev-Mendes model and observe that none of them is able to properly simulate the novel asymptotics of the shortest-path length. Then, we identify the local chainlike linear growth induced by grammar and style as a missing element in this model and extend it by incorporating such effects. It is in this way that a satisfactory agreement with the empirical result is obtained.
Application Delay Modelling for Variable Length Packets in Single Cell IEEE 802.11 WLANs
Sunny, Albert; Aggarwal, Saurabh
2010-01-01
In this paper, we consider the problem of modelling the average delay experienced by an application packets of variable length in a single cell IEEE 802.11 DCF wireless local area network. The packet arrival process at each node i is assumed to be a stationary and independent increment random process with mean ai and second moment a(2) i . The packet lengths at node i are assumed to be i.i.d random variables Pi with finite mean and second moment. A closed form expression has been derived for the same. We assume the input arrival process across queues to be uncorrelated Poison processes. As the nodes share a single channel, they have to contend with one another for a successful transmission. The mean delay for a packet has been approximated by modelling the system as a 1-limited Random Polling system with zero switchover times. Extensive simulations are conducted to verify the analytical results.
Elmore, A.J.; Guinn, S.M.; Minsley, B.J.; Richardson, A.D.
2012-01-01
The timing of spring leaf development, trajectories of summer leaf area, and the timing of autumn senescence have profound impacts to the water, carbon, and energy balance of ecosystems, and are likely influenced by global climate change. Limited field-based and remote-sensing observations have suggested complex spatial patterns related to geographic features that influence climate. However, much of this variability occurs at spatial scales that inhibit a detailed understanding of even the dominant drivers. Recognizing these limitations, we used nonlinear inverse modeling of medium-resolution remote sensing data, organized by day of year, to explore the influence of climate-related landscape factors on the timing of spring and autumn leaf-area trajectories in mid-Atlantic, USA forests. We also examined the extent to which declining summer greenness (greendown) degrades the precision and accuracy of observations of autumn offset of greenness. Of the dominant drivers of landscape phenology, elevation was the strongest, explaining up to 70% of the spatial variation in the onset of greenness. Urban land cover was second in importance, influencing spring onset and autumn offset to a distance of 32 km from large cities. Distance to tidal water also influenced phenological timing, but only within ~5 km of shorelines. Additionally, we observed that (i) growing season length unexpectedly increases with increasing elevation at elevations below 275 m; (ii) along gradients in urban land cover, timing of autumn offset has a stronger effect on growing season length than does timing of spring onset; and (iii) summer greendown introduces bias and uncertainty into observations of the autumn offset of greenness. These results demonstrate the power of medium grain analyses of landscape-scale phenology for understanding environmental controls on growing season length, and predicting how these might be affected by climate change.
Bereczkei, Tamas; Mesko, Norbert
2007-01-01
Multiple Fitness Model states that attractiveness varies across multiple dimensions, with each feature representing a different aspect of mate value. In the present study, male raters judged the attractiveness of young females with neotenous and mature facial features, with various hair lengths. Results revealed that the physical appearance of long-haired women was rated high, regardless of their facial attractiveness being valued high or low. Women rated as most attractive were those whose f...
Simulation Evidence for Nonlocal Interface Models: Two Correlation Lengths Describe Complete Wetting
Pang, Lijun; Landau, D. P.; Binder, K.
2011-06-01
Monte Carlo simulations of (fluctuating) interfaces in Ising models confined between competing walls at temperatures above the wetting transition are presented and various correlation functions probing the interfacial fluctuation are computed. Evidence for the nonlocal interface Hamiltonian approach of A. O. Parry et al. [Phys. Rev. Lett. 93, 086104 (2004)PRLTAO0031-900710.1103/PhysRevLett.93.086104] is given. In particular, we show that two correlation lengths exist with different dependence on the distance D between the walls.
Pang, Lijun; Landau, D P; Binder, K
2011-06-10
Monte Carlo simulations of (fluctuating) interfaces in Ising models confined between competing walls at temperatures above the wetting transition are presented and various correlation functions probing the interfacial fluctuation are computed. Evidence for the nonlocal interface Hamiltonian approach of A. O. Parry et al. [Phys. Rev. Lett. 93, 086104 (2004)] is given. In particular, we show that two correlation lengths exist with different dependence on the distance D between the walls.
The Reactive-Diffusive Length of OH and Ozone in Model Organic Aerosols.
Lee, Lance; Wilson, Kevin
2016-09-01
A key step in the heterogeneous oxidation of atmospheric aerosols is the reaction of ozone (O3) and hydroxyl radicals (OH) at the gas-particle interface. The formation of reaction products and free radical intermediates and their spatial distribution inside the particle is a sensitive function of the length over which these oxidants diffuse prior to reaction. The reactive-diffusive length of OH and ozone at organic aerosol interfaces is determined by observing the change in the effective uptake coefficient for size-selected model aerosols comprising a reactive core and a thin nanometer-sized (0-12 nm) organic shell. The core and shell materials are selected so that they are immiscible and adopt an assumed core-shell configuration. The results indicate a reactive-diffusive length of 1.4 nm for hydroxyl (OH) radicals in squalane and 1.0 nm for ozone in squalene. Measurements for a purely diffusive system allow for an estimate for diffusion constant (1.6 × 10(-6) cm(2)/s) of ozone in squalane to be determined. The reactive-diffusive length offers a simple first order estimate of how shielding of aerosols by immiscible layers can alter estimates of oxidative lifetimes of aerosols in the atmosphere.
Thermomagnetic correlation lengths of strongly interacting matter in the Nambu-Jona-Lasinio model
Ayala, Alejandro; Hernández, L. A.; Loewe, M.; Raya, Alfredo; Rojas, J. C.; Zamora, R.
2017-08-01
We study the correlation length between test quarks with the same electric and color charges in the Nambu-Jona-Lasinio model, considering thermal and magnetic effects. We extract the correlation length from the quark correlation function. The latter is constructed from the probability amplitude to bring a given quark into the plasma once a previous one with the same quantum numbers is placed at a given distance apart. For temperatures below the transition temperature, the correlation length starts growing as the field strength increases to then decrease for large magnetic fields. For temperatures above the pseudocritical temperature, the correlation length continues increasing as the field strength increases. We found that such behavior can be understood as a competition between the tightening induced by the classical magnetic force versus the random thermal motion. For large enough temperatures, the increase of the occupation number contributes to the screening of the interaction between the test particles. The growth of the correlation distance with the magnetic field can be understood as due to the closer proximity between one of the test quarks and the ones popped up from the vacuum, which in turn appear due to the increase of the occupation number with the temperature.
An actuator line model simulation with optimal body force projection length scales
Martinez-Tossas, Luis; Churchfield, Matthew J.; Meneveau, Charles
2016-11-01
In recent work (Martínez-Tossas et al. "Optimal smoothing length scale for actuator line models of wind turbine blades", preprint), an optimal body force projection length-scale for an actuator line model has been obtained. This optimization is based on 2-D aerodynamics and is done by comparing an analytical solution of inviscid linearized flow over a Gaussian body force to the potential flow solution of flow over a Joukowski airfoil. The optimization provides a non-dimensional optimal scale ɛ / c for different Joukowski airfoils, where ɛ is the width of the Gaussian kernel and c is the chord. A Gaussian kernel with different widths in the chord and thickness directions can further reduce the error. The 2-D theory developed is extended by simulating a full scale rotor using the optimal body force projection length scales. Using these values, the tip losses are captured by the LES and thus, no additional explicit tip-loss correction is needed for the actuator line model. The simulation with the optimal values provides excellent agreement with Blade Element Momentum Theory. This research is supported by the National Science Foundation (Grant OISE-1243482, the WINDINSPIRE project).
Ancestry inference in complex admixtures via variable-length Markov chain linkage models.
Rodriguez, Jesse M; Bercovici, Sivan; Elmore, Megan; Batzoglou, Serafim
2013-03-01
Inferring the ancestral origin of chromosomal segments in admixed individuals is key for genetic applications, ranging from analyzing population demographics and history, to mapping disease genes. Previous methods addressed ancestry inference by using either weak models of linkage disequilibrium, or large models that make explicit use of ancestral haplotypes. In this paper we introduce ALLOY, an efficient method that incorporates generalized, but highly expressive, linkage disequilibrium models. ALLOY applies a factorial hidden Markov model to capture the parallel process producing the maternal and paternal admixed haplotypes, and models the background linkage disequilibrium in the ancestral populations via an inhomogeneous variable-length Markov chain. We test ALLOY in a broad range of scenarios ranging from recent to ancient admixtures with up to four ancestral populations. We show that ALLOY outperforms the previous state of the art, and is robust to uncertainties in model parameters.
A mass-length scaling law for modeling muscle strength in the lower limb.
Correa, Tomas A; Pandy, Marcus G
2011-11-10
Musculoskeletal computer models are often used to study muscle function in children with and without impaired mobility. Calculations of muscle forces depend in part on the assumed strength of each muscle, represented by the peak isometric force parameter, which is usually based on measurements obtained from cadavers of adult donors. The aim of the present study was twofold: first, to develop a method for scaling lower-limb peak isometric muscle forces in typically-developing children; and second, to determine the effect of this scaling method on model calculations of muscle forces obtained for normal gait. Muscle volumes were determined from magnetic resonance (MR) images obtained from ten children aged from 7 to 13yr. A new mass-length scaling law was developed based on the assumption that muscle volume and body mass are linearly related, which was confirmed by the obtained volume and body mass data. Two musculoskeletal models were developed for each subject: one in which peak isometric muscle forces were estimated using the mass-length scaling law; and another in which these parameters were determined directly from the MR-derived muscle volumes. Musculoskeletal modeling and quantitative gait analysis were then used to calculate lower-limb muscle forces in normal walking. The patterns of muscle forces predicted by the model with scaled peak isometric force values were similar to those predicted by the MR-based model, implying that assessments of muscle function obtained from these two methods are practically equivalent. These results support the use of mass-length scaling in the development of subject-specific musculoskeletal models of children.
Comparison of model predictions for coherence length to in-flight measurements at cruise conditions
Haxter, Stefan; Spehr, Carsten
2017-03-01
In this paper, we will focus on coherence lengths of pressure fluctuations underneath a turbulent boundary layer on an actual aircraft measured during a flight test. Coherence lengths of pressure fluctuations have already been measured in the past and various models have been set up in order to predict the values. However, most of the underlying data were measured at Mach numbers and pressures different from our region of interest and it is not known if the models are applicable. In some of the investigations also unknown alignment procedures between array and flow were used and it will be shown that this can have a considerable influence on the result. We have performed flight tests at cruising speed and altitude in which we took due account of this alignment by means of an array processing technique which is capable of determining the flow direction for each frequency bin under consideration. In this paper one of the data points will be evaluated and compared to the prediction models. From the differences and subsequently from the adopted run conditions for the measurement of the data of the models, several conclusions are drawn concerning scaling effects and importance of alignment. Also, two of the prediction models are adjusted to our measurements.
TRANSIENT SOLUTION FOR QUEUE-LENGTH DISTRIBUTION OF Geometry/G/1 QUEUEING MODEL
Luo Chuanyi; Tang Yinghui; Liu Renbin
2007-01-01
In this paper, the Geometry/G/1 queueing model with inter-arrival times generated by a geometric(parameter p) distribution according to a late arrival system with delayed access and service times independently distributed with distribution {gj}, j ≥ 1 is studied. By a simple method (techniques of probability decomposition, renewal process theory) that is different from the techniques used by Hunter(1983), the transient property of the queue with initial state i(i ≥ 0) is discussed. The recursion expression for u -transform of transient queue-length distribution at any time point n+ is obtained, and the recursion expression of the limiting queue length distribution is also obtained.
Stewart, David R.; Long, James M.; Shoup, Daniel E.
2016-01-01
Management of Blue Catfish Ictalurus furcatus and Channel Catfish I. punctatus for trophy production has recently become more common. Typically, trophy management is attempted with length-based regulations that allow for the moderate harvest of small fish but restrict the harvest of larger fish. However, the specific regulations used vary considerably across populations, and no modeling efforts have evaluated their effectiveness. We used simulation modeling to compare total yield, trophy biomass (Btrophy), and sustainability (spawning potential ratio [SPR] > 0.30) of Blue Catfish and Channel Catfish populations under three scenarios: (1) current regulation (typically a length-based trophy regulation), (2) the best-performing minimum length regulation (MLRbest), and (3) the best-performing length-based trophy catfish regulation (LTRbest; “best performing” was defined as the regulation that maximized yield, Btrophy, and sustainability). The Btrophy produced did not differ among the three scenarios. For each fishery, the MLRbest and LTRbest produced greater yield (>22% more) than the current regulation and maintained sustainability at higher finite exploitation rates (>0.30) than the current regulation. The MLRbest and LTRbest produced similar yields and SPRs for Channel Catfish and similar yields for Blue Catfish; however, the MLRbest for Blue Catfish produced more resilient fisheries (higher SPR) than the LTRbest. Overall, the variation in yield, Btrophy, and SPR among populations was greater than the variation among regulations applied to any given population, suggesting that population-specific regulations may be preferable to regulations applied to geographic regions. We conclude that LTRs are useful for improving catfish yield and maintaining sustainability without overly restricting harvest but are not effective at increasing the Btrophy of catfish.
Sanchez-Espiridion, Beatriz; Chen, Meng; Chang, Joe Y; Lu, Charles; Chang, David W; Roth, Jack A; Wu, Xifeng; Gu, Jian
2014-05-01
Telomere dysfunction is a crucial event in malignant transformation and tumorigenesis. Telomere length in peripheral blood leukocytes has been associated with lung cancer risk, but the relationship has remained controversial. In this study, we investigated whether the association might be confounded by study of different histological subtypes of lung cancer. We measured relative telomere lengths in patients in a large case-control study of lung cancer and performed stratified analyses according to the two major histologic subtypes [adenocarcinoma and squamous cell carcinoma (SCC)]. Notably, patients with adenocarcinoma had longer telomeres than controls, whereas patients with SCC had shorter telomeres compared with controls. Long telomeres were associated with increased risk of adenocarcinoma, with the highest risk associated with female sex, younger age (telomeres were protective against SCC, particularly in male patients. Our results extend the concept that telomere length affects risk of lung cancer in a manner that differs with histologic subtype.
Modeling and control of thermostatically controlled loads
2011-01-01
As the penetration of intermittent energy sources grows substantially, loads will be required to play an increasingly important role in compensating the fast time-scale fluctuations in generated power. Recent numerical modeling of thermostatically controlled loads (TCLs) has demonstrated that such load following is feasible, but analytical models that satisfactorily quantify the aggregate power consumption of a group of TCLs are desired to enable controller design. We develop such a model for...
Infant bone age estimation based on fibular shaft length: model development and clinical validation
Tsai, Andy; Stamoulis, Catherine; Bixby, Sarah D.; Breen, Micheal A.; Connolly, Susan A.; Kleinman, Paul K. [Boston Children' s Hospital, Harvard Medical School, Department of Radiology, Boston, MA (United States)
2016-03-15
Bone age in infants (<1 year old) is generally estimated using hand/wrist or knee radiographs, or by counting ossification centers. The accuracy and reproducibility of these techniques are largely unknown. To develop and validate an infant bone age estimation technique using fibular shaft length and compare it to conventional methods. We retrospectively reviewed negative skeletal surveys of 247 term-born low-risk-of-abuse infants (no persistent child protection team concerns) from July 2005 to February 2013, and randomized them into two datasets: (1) model development (n = 123) and (2) model testing (n = 124). Three pediatric radiologists measured all fibular shaft lengths. An ordinary linear regression model was fitted to dataset 1, and the model was evaluated using dataset 2. Readers also estimated infant bone ages in dataset 2 using (1) the hemiskeleton method of Sontag, (2) the hemiskeleton method of Elgenmark, (3) the hand/wrist atlas of Greulich and Pyle, and (4) the knee atlas of Pyle and Hoerr. For validation, we selected lower-extremity radiographs of 114 normal infants with no suspicion of abuse. Readers measured the fibulas and also estimated bone ages using the knee atlas. Bone age estimates from the proposed method were compared to the other methods. The proposed method outperformed all other methods in accuracy and reproducibility. Its accuracy was similar for the testing and validating datasets, with root-mean-square error of 36 days and 37 days; mean absolute error of 28 days and 31 days; and error variability of 22 days and 20 days, respectively. This study provides strong support for an infant bone age estimation technique based on fibular shaft length as a more accurate alternative to conventional methods. (orig.)
Sequence Length Limits for Controlling False Positives in Discovering Nucleotide Sequence Motifs
CHEN Lei; QiAN Zi-liang
2008-01-01
In the study of motif discovery, especially the transcription factor DNA binding sites discovery, a too long input sequence would return non-informative motifs rather than those biological functional motifs. This paper gave theoretical analyses and computational experiments to suggest the length limits of the input sequence. When the sequence length exceeds a certain critical point, the probability of discovering the motif decreases sharply. The work not only gave an explanation on the unsatisfying results of the existed motif discovery problems that the input sequence length might be too long and exceed the point, but also provided an estimation of input sequence length we should accept to get more meaningful and reliable results in motif discovery.
Mendoza-Torres, F.; Diaz-Viera, M. A.
2015-12-01
In many natural fractured porous media, such as aquifers, soils, oil and geothermal reservoirs, fractures play a crucial role in their flow and transport properties. An approach that has recently gained popularity for modeling fracture systems is the Discrete Fracture Network (DFN) model. This approach consists in applying a stochastic boolean simulation method, also known as object simulation method, where fractures are represented as simplified geometric objects (line segments in 2D and polygons in 3D). One of the shortcomings of this approach is that it usually does not consider the dependency relationships that may exist between the geometric properties of fractures (direction, length, aperture, etc), that is, each property is simulated independently. In this work a method for modeling such dependencies by copula theory is introduced. In particular, a nonparametric model using Bernstein copulas for direction-length fracture dependency in 2D is presented. The application of this method is illustrated in a case study for a fractured rock sample from a carbonate reservoir outcrop.
Liu Tong; Liao Xiaoping; Wang Debo
2011-01-01
A Fourier equivalent model is introduced to research the thermal transfer behavior of a terminatingtype MEMS microwave power sensor.The fabrication of this MEMS microwave power sensor is compatible with the GaAs MMIC process.Based on the Fourier equivalent model,the relationship between the sensitivity of a MEMS microwave power sensor and the length of thermopile is studied in particular.The power sensor is measured with an input power from 1 to 100 mW at 10 GHz,and the measurement results show that the power sensor has good input match characteristics and high linearity.The sensitivity calculated from a Fourier equivalent model is about 0.12,0.20 and 0.29 mV/mW with the length at 40,70 and 100 μm,respectively,while the sensitivity of the measurement results is about 0.10,0.22 and 0.30 mV/mW,respectively,and the differences are below 0.02 mV/mW.The sensitivity expression based on the Fourier equivalent model is verified by the measurement results.
Omar, M.S., E-mail: dr_m_s_omar@yahoo.com [Department of Physics, College of Science, University of Salahaddin-Erbil, Arbil, Kurdistan (Iraq)
2012-11-15
Graphical abstract: Three models are derived to explain the nanoparticles size dependence of mean bonding length, melting temperature and lattice thermal expansion applied on Sn, Si and Au. The following figures are shown as an example for Sn nanoparticles indicates hilly applicable models for nanoparticles radius larger than 3 nm. Highlights: ► A model for a size dependent mean bonding length is derived. ► The size dependent melting point of nanoparticles is modified. ► The bulk model for lattice thermal expansion is successfully used on nanoparticles. -- Abstract: A model, based on the ratio number of surface atoms to that of its internal, is derived to calculate the size dependence of lattice volume of nanoscaled materials. The model is applied to Si, Sn and Au nanoparticles. For Si, that the lattice volume is increases from 20 Å{sup 3} for bulk to 57 Å{sup 3} for a 2 nm size nanocrystals. A model, for calculating melting point of nanoscaled materials, is modified by considering the effect of lattice volume. A good approach of calculating size-dependent melting point begins from the bulk state down to about 2 nm diameter nanoparticle. Both values of lattice volume and melting point obtained for nanosized materials are used to calculate lattice thermal expansion by using a formula applicable for tetrahedral semiconductors. Results for Si, change from 3.7 × 10{sup −6} K{sup −1} for a bulk crystal down to a minimum value of 0.1 × 10{sup −6} K{sup −1} for a 6 nm diameter nanoparticle.
Active control: Wind turbine model
Bindner, Henrik
1999-07-01
This report is a part of the reporting of the work done in the project `Active Control of Wind Turbines`. This project aim is to develop a simulation model for design of control systems for turbines with pitch control and to use that model to design controllers. This report describes the model developed for controller design and analysis. Emphasis has been put on establishment of simple models describing the dynamic behavior of the wind turbine in adequate details for controller design. This has been done with extensive use of measurements as the basis for selection of model complexity and model validation as well as parameter estimation. The model includes a simple model of the structure of the turbine including tower and flapwise blade bending, a detailed model of the gear box and induction generator, a linearized aerodynamic model including modelling of induction lag and actuator and sensor models. The models are all formulated as linear differential equations. The models are validated through comparisons with measurements performed on a Vestas WD 34 400 kW wind turbine. It is shown from a control point of view simple linear models can be used to describe the dynamic behavior of a pitch controlled wind turbine. The model and the measurements corresponds well in the relevant frequency range. The developed model is therefore applicable for controller design. (au) EFP-91. 18 ills., 22 refs.
Active control: Wind turbine model
Bindner, H.
1999-01-01
This report is a part of the reporting of the work done in the project 'Active Control of Wind Turbines'. This project aim is to develop a simulation model for design of control systems for turbines with pitch control and to use that model to designcontrollers. This report describes the model...... developed for controller design and analysis. Emphasis has been put on establishment of simple models describing the dynamic behavior of the wind turbine in adequate details for controller design. This hasbeen done with extensive use of measurements as the basis for selection of model complexity and model...... validation as well as parameter estimation. The model includes a simple model of the structure of the turbine including tower and flapwise blade bending,a detailed model of the gear box and induction generator, a linearized aerodynamic model including modelling of induction lag and actuator and sensor models...
闫洪; 王高潮; 夏巨谌; 李志刚
2004-01-01
Based on the finite element simulation of profile extrusion process, the effect of local extrusion ratio, die bearing area and the distance between extrusion cylindrical center and local die orfice center on mental flow velocity was investigated. The laws of deformed metalflow on profile extrusion process were obtained. The smaller the local extrusion ratio, the faster the metal flow velocity; the smaller the area of die bearing, the faster the metal flow velocity; the smaller the distance of position of local die orifice(the closer the distance of position of local die orifice from extrusion cylindrical axis), the faster the metal flow velocity. The effect of main parameters of die structure on metal flow velocity was integrated and the mathematical model of determination of die bearing length in design of aluminum profile extrusion die was proposed. The calculated results with proposed model were well compared with the experimental results. The proposed model can be applied to determine die bearing length in design of aluminum profile extrusion die.
Implementation of a Mixing Length Turbulence Formulation Into the Dynamic Wake Meandering Model
Keck, Rolf-Erik; Veldkamp, Dick; Aagaard Madsen, Helge
2012-01-01
The work presented in this paper focuses on improving the description of wake evolution due to turbulent mixing in the dynamic wake meandering (DWM) model. From wake investigations performed with high-fidelity actuator line simulations carried out in ELLIPSYS3D, it is seen that the current DWM...... description, where the eddy viscosity is assumed to be constant in each cross-section of the wake, is insufficient. Instead, a two-dimensional eddy viscosity formulation is proposed to model the shear layer generated turbulence in the wake, based on the classical mixing length model. The performance...... from 3 to 12 diameters behind the rotor, is reduced by 27% by using the new eddy viscosity formulation. ©2012 American Society of Mechanical Engineers...
Lower Length Scale Model Development for Embrittlement of Reactor Presure Vessel Steel
Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States); Schwen, Daniel [Idaho National Lab. (INL), Idaho Falls, ID (United States); Chakraborty, Pritam [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bai, Xianming [Idaho National Lab. (INL), Idaho Falls, ID (United States)
2016-09-01
This report summarizes the lower-length-scale effort during FY 2016 in developing mesoscale capabilities for microstructure evolution, plasticity and fracture in reactor pressure vessel steels. During operation, reactor pressure vessels are subject to hardening and embrittlement caused by irradiation induced defect accumulation and irradiation enhanced solute precipitation. Both defect production and solute precipitation start from the atomic scale, and manifest their eventual effects as degradation in engineering scale properties. To predict the property degradation, multiscale modeling and simulation are needed to deal with the microstructure evolution, and to link the microstructure feature to material properties. In this report, the development of mesoscale capabilities for defect accumulation and solute precipitation are summarized. A crystal plasticity model to capture defect-dislocation interaction and a damage model for cleavage micro-crack propagation is also provided.
Comparing mixing-length models of the diabatic wind profile over homogeneous terrain
Peña, Alfredo; Gryning, Sven-Erik; Hasager, Charlotte Bay
2010-05-01
Models of the diabatic wind profile over homogeneous terrain for the entire atmospheric boundary layer are developed using mixing-length theory and are compared to wind speed observations up to 300 m at the National Test Station for Wind Turbines at Høvsøre, Denmark. The measurements are performed within a wide range of atmospheric stability conditions, which allows a comparison of the models with the average wind profile computed in seven stability classes, showing a better agreement than compared to the traditional surface-layer wind profile. The wind profile is measured by combining cup anemometer and lidar observations, showing good agreement at the overlapping heights. The height of the boundary layer, a parameter required for the wind profile models, is estimated under neutral and stable conditions using surface-layer turbulence measurements, and under unstable conditions based on the aerosol backscatter profile from ceilometer observations.
Jassby, D; Xiao, Y; Schuler, A J
2014-01-01
Settling of the biomass produced during biological treatment of wastewater is a critical and often problematic process. Filamentous bacteria content is the best-known factor affecting biomass settleability in activated sludge wastewater treatment systems, and varying biomass density has recently been shown to play an important role as well. The objective of this study was to systematically determine how filament content and biomass density combine to affect microbial biomass settling, with a focus on density variations over the range found in full-scale systems. A laboratory-scale bioreactor system was operated to produce biomass with a range of filamentous bacterium contents. Biomass density was systematically varied in samples from this system by addition of synthetic microspheres to allow separation of filament content and density effects on settleability. Fluorescent in-situ hybridization indicated that the culture was dominated by Sphaerotilus natans, a common contributor to poor settling in full-scale systems. A simple, image-based metric of filament content (filament length per floc area) was linearly correlated with the more commonly used filament length per dry biomass measurement. A non-linear, semi-empirical model of settleability as a function of filament content and density was developed and evaluated, providing a better understanding of how these two parameters combine to affect settleability. Filament content (length per dry biomass weight) was nearly linearly related to sludge volume index (SVI) values, with a slightly decreasing differential, and biomass density exhibited an asymptotic relationship with SVI. The filament content associated with bulking was shown to be a function of biomass density. The marginal effect of filament content on settleability increased with decreasing biomass density (low density biomass was more sensitive to changes in filament content than was high density biomass), indicating a synergistic relationship between these
Lee, Deukhwan; Misztal, Ignacy; Bertrand, J Keith; Rekaya, Romdhane
2002-01-01
Data included 393,097 calving ease, 129,520 gestation length, and 412,484 birth weight records on 412,484 Gelbvieh cattle. Additionally, pedigrees were available on 72,123 animals. Included in the models were effects of sex and age of dam, treated as fixed, as well as direct, maternal genetic and permanent environmental effects and effects of contemporary group (herd-year-season), treated as random. In all analyses, birth weight and gestation length were treated as continuous traits. Calving ease (CE) was treated either as a continuous trait in a mixed linear model (LM), or as a categorical trait in linear-threshold models (LTM). Solutions in TM obtained by empirical Bayes (TMEB) and Monte Carlo (TMMC) methodologies were compared with those by LM. Due to the computational cost, only 10,000 samples were obtained for TMMC. For calving ease, correlations between LM and TMEB were 0.86 and 0.78 for direct and maternal genetic effects, respectively. The same correlations but between TMEB and TMMC were 1.00 and 0.98, respectively. The correlations between LM and TMMC were 0.85 and 0.75, respectively. The correlations for the linear traits were above.97 between LM and TMEB but as low as 0.91 between LM and TMMC, suggesting insufficient convergence of TMMC. Computing time required was about 2 hrs, 5 hrs, and 6 days for LM, TMEB and TMMC, respectively, and memory requirements were 169, 171, and 445 megabytes, respectively. Bayesian implementation of threshold model is simple, can be extended to multiple categorical traits, and allows easy calculation of accuracies; however, computing time is prohibitively long for large models.
Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length
Hamilton, Nicola B; Clarke, Laura E; Arancibia-Carcamo, I Lorena;
2016-01-01
Adjusting the thickness and internodal length of the myelin sheath is a mechanism for tuning the conduction velocity of axons to match computational needs. Interactions between oligodendrocyte precursor cells (OPCs) and developing axons regulate the formation of myelin around axons. We now show, ...
Length of efficacy for control of curly top in sugar beet with seed foliar insecticides
Curly top in sugar beet caused by Beet curly top virus (BCTV) is an important yield limiting disease that can be reduced via neonicotinoid and pyrethroid insecticides. However the length of efficacy of these insecticides is poorly understood, so a series of field experiments was conducted with the ...
Sepsis Alert - a triage model that reduces time to antibiotics and length of hospital stay.
Rosenqvist, Mari; Fagerstrand, Emma; Lanbeck, Peter; Melander, Olle; Åkesson, Per
2017-07-01
To study if a modified triage system at an Emergency Department (ED) combined with educational efforts resulted in reduced time to antibiotics and decreased length of hospital stay (LOS) for patients with severe infection. A retrospective, observational study comparing patients before and after the start of a new triage model at the ED of a University Hospital. After the implementation of the model, patients with fever and abnormal vital signs were triaged into a designated sepsis line (Sepsis Alert) for rapid evaluation by the attending physician supported by a infectious diseases (IDs) specialist. Also, all ED staff participated in a designated sepsis education before Sepsis Alert was introduced. Medical records were evaluated for patients during a 3-month period after the triage system was started in 2012, and also during the corresponding months in 2010 and 2014. A total of 1837 patients presented with abnormal vital signs. Of these, 221 patients presented with fever and thus at risk of having severe sepsis. Among patients triaged according to the new model, median time to antibiotics was 58.5 at startup and 24.5 minutes at follow-up two years later. This was significantly less than for patients treated before the new model, 190 minutes. Also, median LOS was significantly decreased after introduction of the new triage model, from nine to seven days. A triage model at the ED with special attention to severe sepsis patients, led to sustained improvements of time to antibiotic treatment and LOS.
Disrattakit, P.; Chanphana, R.; Chatraphorn, P.
2016-11-01
Conventionally, the universality class of a discrete growth model is identified via the scaling of interface width. This method requires large-scale simulations to minimize finite-size effects on the results. The multiple hit noise reduction techniques (m > 1 NRT) and the long surface diffusion length noise reduction techniques (ℓ > 1 NRT) have been used to promote the asymptotic behaviors of the growth models. Lately, an alternative method involving comparison of roughness distribution in the steady state has been proposed. In this work, the roughness distribution of the (2 +1)-dimensional Das Sarma-Tamborenea (DT), Wolf-Villain (WV), and Larger Curvature (LC) models, with and without NRTs, are calculated in order to investigate effects of the NRTs on the roughness distribution. Additionally, effective growth exponents of the noise reduced (2 +1)-dimensional DT, WV and LC models are also calculated. Our results indicate that the NRTs affect the interface width both in the growth and the saturation regimes. In the steady state, the NRTs do not seem to have any impact on the roughness distribution of the DT model, but it significantly changes the roughness distribution of the WV and LC models to the normal distribution curves.
Simon Abson
2015-03-01
Full Text Available Arthroplasty is increasingly performed within Australia, with a 2.7% rate increase of total knee arthroplasty (TKR over the last year. With an increasing burden on the public health system and increasing waiting lists, all efforts are being made to decrease length of stay and improve the post operative rehabilitation process. There is currently insufficient evidence to make a conclusive statement about visual aids and improved goal attainment post TKR. The purpose of this study is to evaluate one such visual aid clinical photographs of patients knee range of motion (ROM pre- and post-operatively and their effect on length of stay. Photographs of knee range of motion were obtained pre and post-operatively while the patient was anesthetized. In this study, a randomized, single blinded design allocated patients to either be shown or not shown their photographs on day 1 post operatively. Primary outcome measures were the number of days the patient remained in hospital. Secondary measures were Western Ontario and McMaster Universities Arthritis Index scores, Oxford Knee Scores, American Society of Anesthesiologists Score and knee ROM. Thirty-two patients (3 exclusions were randomized to the photo group and 27 patients (4 exclusions were randomized to the no photo group. The median length of stay between groups was not significantly different. Currently there is not enough evidence to conclude that visual aids effect length of stay or rehabilitation pathways. Further assessment with larger cohort groups is needed. Preoperative targeting and rehabilitation for patients with lower functional status may shorten post operative length of patient stay in our institution.
Modeling and control of thermostatically controlled loads
Backhaus, Scott N [Los Alamos National Laboratory; Sinitsyn, Nikolai [Los Alamos National Laboratory; Kundu, S. [UNIV OF MICHIGAN; Hiskens, I. [UNIV OF MICHIGAN
2011-01-04
As the penetration of intermittent energy sources grows substantially, loads will be required to play an increasingly important role in compensating the fast time-scale fluctuations in generated power. Recent numerical modeling of thermostatically controlled loads (TCLs) has demonstrated that such load following is feasible, but analytical models that satisfactorily quantify the aggregate power consumption of a group of TCLs are desired to enable controller design. We develop such a model for the aggregate power response of a homogeneous population of TCLs to uniform variation of all TCL setpoints. A linearized model of the response is derived, and a linear quadratic regulator (LQR) has been designed. Using the TCL setpoint as the control input, the LQR enables aggregate power to track reference signals that exhibit step, ramp and sinusoidal variations. Although much of the work assumes a homogeneous population of TCLs with deterministic dynamics, we also propose a method for probing the dynamics of systems where load characteristics are not well known.
Model of a fluid at small and large length scales and the hydrophobic effect
tenWolde, Pieter Rein; Sun, Sean X.; Chandler, David
2001-01-01
We present a statistical field theory to describe large length scale effects induced by solutes in a cold and otherwise placid liquid. The theory divides space into a cubic grid of cells. The side length of each cell is of the order of the bulk correlation length of the bulk liquid. Large length scale states of the cells are specified with an Ising variable. Finer length scale effects are described with a Gaussian field, with mean and variance affected by both the large length scale field and...
Evaluating the accuracy of finite element models at reduced length scales
Kemp, Connor
Finite element models are used frequently in both engineering and scientific research. While they can provide useful information as to the performance of materials, as length scales are decreased more sophisticated model descriptions are required. It is also important to develop methods by which existing models may be verified against experimental findings. The present study evaluates the ability of various finite element models to predict materials behaviour at length scales ranging from several microns to tens of nanometers. Considering this motivation, this thesis is provided in manuscript form with the bulk of material coming from two case studies. Following an overview of relevant literature in Chapter 2, Chapter 3 considers the nucleation of delta-zirconium hydrides in a Zircaloy-2 matrix. Zirconium hydrides are an important topic in the nuclear industry as they form a brittle phase which leads to delayed hydride cracking during reactor start-up and shut-down. Several FE models are used to compare present results with literature findings and illustrate the weaknesses of standard FE approaches. It is shown that standard continuum techniques do not sufficiently capture the interfacial effects of an inclusion-matrix system. By using nano-scale material descriptions, nucleation lattice strains are obtained which are in good agreement with previous experimental studies. The motivation for Chapter 4 stems from a recognized need to develop a method for modeling corrosion behaviour of materials. Corrosion is also an issue for reactor design and an ability to predict failure points is needed. Finite element models could be used for this purpose, provided model accuracy is verified first. In Chapter 4 a technique is developed which facilitates the extraction of sub-micron resolution strain data from correlation images obtained during in-situ tensile deformation. By comparing image correlation results with a crystal plasticity finite element code it is found that good
Systematic review of risk adjustment models of hospital length of stay (LOS).
Lu, Mingshan; Sajobi, Tolulope; Lucyk, Kelsey; Lorenzetti, Diane; Quan, Hude
2015-04-01
Policy decisions in health care, such as hospital performance evaluation and performance-based budgeting, require an accurate prediction of hospital length of stay (LOS). This paper provides a systematic review of risk adjustment models for hospital LOS, and focuses primarily on studies that use administrative data. MEDLINE, EMBASE, Cochrane, PubMed, and EconLit were searched for studies that tested the performance of risk adjustment models in predicting hospital LOS. We included studies that tested models developed for the general inpatient population, and excluded those that analyzed risk factors only correlated with LOS, impact analyses, or those that used disease-specific scales and indexes to predict LOS. Our search yielded 3973 abstracts, of which 37 were included. These studies used various disease groupers and severity/morbidity indexes to predict LOS. Few models were developed specifically for explaining hospital LOS; most focused primarily on explaining resource spending and the costs associated with hospital LOS, and applied these models to hospital LOS. We found a large variation in predictive power across different LOS predictive models. The best model performance for most studies fell in the range of 0.30-0.60, approximately. The current risk adjustment methodologies for predicting LOS are still limited in terms of models, predictors, and predictive power. One possible approach to improving the performance of LOS risk adjustment models is to include more disease-specific variables, such as disease-specific or condition-specific measures, and functional measures. For this approach, however, more comprehensive and standardized data are urgently needed. In addition, statistical methods and evaluation tools more appropriate to LOS should be tested and adopted.
Brunelli, Nicholas A; Didas, Stephanie A; Venkatasubbaiah, Krishnan; Jones, Christopher W
2012-08-29
Cooperative interactions between aminoalkylsilanes and silanols on a silica surface can be controlled by varying the length of the alkyl linker attaching the amine to the silica surface from C1 (methyl) to C5 (pentyl). The linker length strongly affects the catalytic cooperativity of amines and silanols in aldol condensations as well as the adsorptive cooperativity for CO(2) capture. The catalytic cooperativity increases with the linker length up to propyl (C3), with longer, more flexible linkers (up to C5) providing no additional benefit or hindrance. Short linkers (C1 and C2) limit the beneficial amine-silanol cooperativity in aldol condensations, resulting in lower catalytic rates than with the C3+ linkers. For the same materials, the adsorptive cooperativity exhibits similar trends for CO(2) capture efficiency.
Controlling Modelling Artifacts
Smith, Michael James Andrew; Nielson, Flemming; Nielson, Hanne Riis
2011-01-01
the possible configurations of the system (for example, by counting the number of components in a certain state). We motivate our methodology with a case study of the LMAC protocol for wireless sensor networks. In particular, we investigate the accuracy of a recently proposed high-level model of LMAC......When analysing the performance of a complex system, we typically build abstract models that are small enough to analyse, but still capture the relevant details of the system. But it is difficult to know whether the model accurately describes the real system, or if its behaviour is due to modelling...... artifacts that were inadvertently introduced. In this paper, we propose a novel methodology to reason about modelling artifacts, given a detailed model and a highlevel (more abstract) model of the same system. By a series of automated abstraction steps, we lift the detailed model to the same state space...
Hill, Jon; Piggott, M. D.; Ham, David A.; Popova, E. E.; Srokosz, M. A.
2012-10-01
Research into the use of unstructured mesh methods for ocean modelling has been growing steadily in the last few years. One advantage of using unstructured meshes is that one can concentrate resolution where it is needed. In addition, dynamic adaptive mesh optimisation (DAMO) strategies allow resolution to be concentrated when this is required. Despite the advantage that DAMO gives in terms of improving the spatial resolution where and when required, small-scale turbulence in the oceans still requires parameterisation. A two-equation, generic length scale (GLS) turbulence model (one equation for turbulent kinetic energy and another for a generic turbulence length-scale quantity) adds this parameterisation and can be used in conjunction with adaptive mesh techniques. In this paper, an implementation of the GLS turbulence parameterisation is detailed in a non-hydrostatic, finite-element, unstructured mesh ocean model, Fluidity-ICOM. The implementation is validated by comparing to both a laboratory-scale experiment and real-world observations, on both fixed and adaptive meshes. The model performs well, matching laboratory and observed data, with resolution being adjusted as necessary by DAMO. Flexibility in the prognostic fields used to construct the error metric used in DAMO is required to ensure best performance. Moreover, the adaptive mesh models perform as well as fixed mesh models in terms of root mean square error to observation or theoretical mixed layer depths, but uses fewer elements and hence has a reduced computational cost.
Modelling and controlling hydropower plants
Munoz-Hernandez, German Ardul; Jones, Dewi Ieuan
2013-01-01
Hydroelectric power stations are a major source of electricity around the world; understanding their dynamics is crucial to achieving good performance. Modelling and Controlling Hydropower Plants discusses practical and well-documented cases of modelling and controlling hydropower station modelling and control, focussing on a pumped storage scheme based in Dinorwig, North Wales. Single-input-single-output and multiple-input-multiple-output models, which cover the linear and nonlinear characteristics of pump-storage hydroelectric power stations, are reviewed. The most important dynamic features are discussed, and the verification of these models by hardware in the loop simulation is described. To show how the performance of a pump-storage hydroelectric power station can be improved, classical and modern controllers are applied to simulated models of the Dinorwig power plant. These include PID, fuzzy approximation, feed-forward and model-based predictive control with linear and hybrid prediction models. Mod...
Prediction model for the diffusion length in silicon-based solar cells
Cheknane A; Benouaz T
2009-01-01
d to predict the diffusion length in mono-crystalline silicon solar cells. Furthermore, the computation of the diffusion length and the comparison with measurement data, using the infrared injection method, are presented and discussed.
Seed Length Controlled by Same Locus in Four Different AA Genome Species of Genus Oryza
ZHANG Yu; LI Jing; ZHOU Jia-wu; XU Peng; DENG Xian-neng; YANG Fei; DENG Wei; HU Feng-yi; TAO Da-yun
2014-01-01
To broaden the genetic basis and overcome the yield plateau in Asian cultivated rice, the exploitation and utilization of favorable alleles from rice species with the AA genome has become important and urgent in modern breeding programs. Four different interspecific populations were used to detect quantitative trait locus (QTL) for seed length, including a BC4F2 population derived from Oryza glumaepatula crossed with Dianjingyou 1 (a japonica cultivar), a BC4F2 population derived from O. nivara crossed with Dianjingyou 1, a BC7F1 population derived from a cross between O. longistaminata and RD23 (an indica cultivar), and a BC8F1 population derived from a cross between O. glaberrima and Dianjingyou 1. The QTLs for seed length in four different populations were termed as SL-3a, SL-3b, SL-3c and SL-3d, respectively. They had good collinearity and accounted for 49% to 60% of the phenotypic variations. Sequencing data indicated that four QTLs were different alleles of GS3 which were responsible for the seed length variation between O. sativa and its four AA genome relatives. These results will be valuable for confirming the evolution of GS3 and also be helpful for rice breeding.
Controlling Modelling Artifacts
Smith, Michael James Andrew; Nielson, Flemming; Nielson, Hanne Riis
2011-01-01
as the high-level model, so that they can be directly compared. There are two key ideas in our approach — a temporal abstraction, where we only look at the state of the system at certain observable points in time, and a spatial abstraction, where we project onto a smaller state space that summarises...... artifacts that were inadvertently introduced. In this paper, we propose a novel methodology to reason about modelling artifacts, given a detailed model and a highlevel (more abstract) model of the same system. By a series of automated abstraction steps, we lift the detailed model to the same state space...
Engine Modelling for Control Applications
Hendricks, Elbert
1997-01-01
In earlier work published by the author and co-authors, a dynamic engine model called a Mean Value Engine Model (MVEM) was developed. This model is physically based and is intended mainly for control applications. In its newer form, it is easy to fit to many different engines and requires little...... engine data for this purpose. It is especially well suited to embedded model applications in engine controllers, such as nonlinear observer based air/fuel ratio and advanced idle speed control. After a brief review of this model, it will be compared with other similar models which can be found...
Sharma, A.S.; Limebeer, D.J.N.; Jaimoukha, I.M.; Lister, J.B
2001-11-01
A new approach to the modelling and control of tokamak fusion reactors is presented. A nonlinear model is derived using the classical arguments of Hamiltonian mechanics and a low-order linear model is derived from it. The modelling process used here addresses flux and energy conservation issues explicitly and self-consistently. The model is of particular value, because it shows the relationship between the initial modelling assumptions and the resulting predictions. The mechanisms behind the creation of uncontrollable modes in tokamak models are discussed. A normalised coprime factorisation controller is developed for the TCV tokamak using the verified linear model. Recent theory is applied to reduce the controller order significantly whilst guaranteeing a priori bounds on the robust stability and performance. The controller is shown to track successfully reference signals that dictate the plasma's shape, position and current. The tests used to verify this were carried out on linear and nonlinear models. (author)
Modeling and Control for Microgrids
Steenis, Joel
Traditional approaches to modeling microgrids include the behavior of each inverter operating in a particular network configuration and at a particular operating point. Such models quickly become computationally intensive for large systems. Similarly, traditional approaches to control do not use advanced methodologies and suffer from poor performance and limited operating range. In this document a linear model is derived for an inverter connected to the Thevenin equivalent of a microgrid. This model is then compared to a nonlinear simulation model and analyzed using the open and closed loop systems in both the time and frequency domains. The modeling error is quantified with emphasis on its use for controller design purposes. Control design examples are given using a Glover McFarlane controller, gain scheduled Glover McFarlane controller, and bumpless transfer controller which are compared to the standard droop control approach. These examples serve as a guide to illustrate the use of multi-variable modeling techniques in the context of robust controller design and show that gain scheduled MIMO control techniques can extend the operating range of a microgrid. A hardware implementation is used to compare constant gain droop controllers with Glover McFarlane controllers and shows a clear advantage of the Glover McFarlane approach.
Chi Wu; Zuo-wei Xie; Guang-zhao Zhang; Guo-fu Zi
2001-01-01
It had very long been a dream in polymer science to synthesize long multi-block polymer chains with an ordered chain sequence and controllable block lengths. Using ionic or living free radical polymerization or furnishing each end of polymer blocks with a reactive functional group, one can only prepare heteropolymer chains with few long blocks, such as diblock and triblock copolymers. The most plausible result so far was a pentablock copolymer. Recently, using a combination of polymer physics and synthetic chemistry, we have invented self-assembly assisted polycondensation (SAAP). This communication reports the results of using this novel method to connect 10-100 triblock polymer chains together to form long multi-block heteropolymer chains with an ordered sequence and controllable block lengths.``
OsGRF4 controls grain shape, panicle length and seed shattering in rice.
Sun, Pingyong; Zhang, Wuhan; Wang, Yihua; He, Qiang; Shu, Fu; Liu, Hai; Wang, Jie; Wang, Jianmin; Yuan, Longping; Deng, Huafeng
2016-10-01
Traits such as grain shape, panicle length and seed shattering, play important roles in grain yield and harvest. In this study, the cloning and functional analysis of PANICLE TRAITS 2 (PT2), a novel gene from the Indica rice Chuandali (CDL), is reported. PT2 is synonymous with Growth-Regulating Factor 4 (OsGRF4), which encodes a growth-regulating factor that positively regulates grain shape and panicle length and negatively regulates seed shattering. Higher expression of OsGRF4 is correlated with larger grain, longer panicle and lower seed shattering. A unique OsGRF4 mutation, which occurs at the OsmiRNA396 target site of OsGRF4, seems to be associated with high levels of OsGRF4 expression, and results in phenotypic difference. Further research showed that OsGRF4 regulated two cytokinin dehydrogenase precursor genes (CKX5 and CKX1) resulting in increased cytokinin levels, which might affect the panicle traits. High storage capacity and moderate seed shattering of OsGRF4 may be useful in high-yield breeding and mechanized harvesting of rice. Our findings provide additional insight into the molecular basis of panicle growth. © 2016 The Authors. Journal of Integrative Plant Biology Published by John Wiley & Sons Australia, Ltd on behalf of Institute of Botany, Chinese Academy of Sciences.
Li, Cheng; Wu, Alex Chi; Go, Rob Marc; Malouf, Jacob; Turner, Mark S; Malde, Alpeshkumar K; Mark, Alan E; Gilbert, Robert G
2015-01-01
Starch is a complex branched glucose polymer whose branch molecular weight distribution (the chain-length distribution, CLD) influences nutritionally important properties such as digestion rate. Chain-stopping in starch biosynthesis is by starch branching enzyme (SBE). Site-directed mutagenesis was used to modify SBEIIa from Zea mays (mSBEIIa) to produce mutants, each differing in a single conserved amino-acid residue. Products at different times from in vitro branching were debranched and the time evolution of the CLD measured by size-exclusion chromatography. The results confirm that Tyr352, Glu513, and Ser349 are important for mSBEIIa activity while Arg456 is important for determining the position at which the linear glucan is cut. The mutant mSBEIIa enzymes have different activities and suggest the length of the transferred chain can be varied by mutation. The work shows analysis of the molecular weight distribution can yield information regarding the enzyme branching sites useful for development of plants yielding starch with improved functionality.
Increasing LIGO sensitivity by feedforward subtraction of auxiliary length control noise
Meadors, Grant; Kawabe, Keita; Riles, Keith
2013-04-01
LIGO, the Laser Interferometer Gravitational-wave Observatory [Hanford, Washington and Livingston, Louisiana] measures the differential length of 4-km Michelson arms with Fabry-Perot cavities. Length changes could indicate strain caused by astrophysical sources of gravitational waves. Fundamentally limited by seismic noise, thermal suspension noise, and laser shot noise in different frequency bands, a LIGO interferometer's sensitivity can also be degraded by additional relative motion of the inner arm cavity mirrors due to imperfectly-servoed Michelson motion. In this project we seek to subtract the effects of this residual motion by feedforward correction of the gravitational-wave data channel. We divide data from LIGO's sixth science run into 1024-second time windows and numerically fit a filter representing the frequency-domain transfer function from Michelson servo noise to gravitational wave channel for each window. Finally, the Michelson servo channel is processed through the filter and is subtracted from the gravitational-wave signal channel. The algorithm used in this procedure will be described with a preliminary assessment of the achievable sensitivity improvement.
OsGRF4 controls grain shape, panicle length and seed shattering in rice
Pingyong Sun; Huafeng Deng; Wuhan Zhang; Yihua Wang; Qiang He; Fu Shu; Hai Liu; Jie Wang; Jianmin Wang; Longping Yuan
2016-01-01
Traits such as grain shape, panicle length and seed shattering, play important roles in grain yield and harvest. In this study, the cloning and functional analysis of PANICLE TRAITS 2 (PT2), a novel gene from the Indica rice Chuandali (CDL), is reported. PT2 is synonymous with Growth-Regulating Factor 4 (OsGRF4), which encodes a growth-regulating factor that positively regulates grain shape and panicle length and negatively regulates seed shattering. Higher expression of OsGRF4 is correlated with larger grain, longer panicle and lower seed shattering. A unique OsGRF4 mutation, which occurs at the OsmiRNA396 target site of OsGRF4, seems to be associated with high levels of OsGRF4 expression, and results in phenotypic difference. Further research showed that OsGRF4 regulated two cytokinin dehydrogenase precursor genes (CKX5 and CKX1) resulting in increased cytokinin levels, which might affect the panicle traits. High storage capacity and moderate seed shattering of OsGRF4 may be useful in high-yield breeding and mechanized harvesting of rice. Our findings provide additional insight into the molecular basis of panicle growth.
Kennedy Hugh
2008-10-01
Full Text Available Abstract Background Telomeres are DNA repeat sequences necessary for DNA replication which shorten at cell division at a rate directly related to levels of oxidative stress. Critical telomere shortening predisposes to cell senescence and to epithelial malignancies. Type 2 diabetes is characterised by increased oxidative DNA damage, telomere attrition, and an increased risk of colonic malignancy. We hypothesised that the colonic mucosa in Type 2 diabetes would be characterised by increased DNA damage and telomere shortening. Methods We examined telomere length (by flow fluorescent in situ hybridization and oxidative DNA damage (flow cytometry of 8 – oxoguanosine in the colonic mucosal cells of subjects with type 2 diabetes (n = 10; mean age 62.2 years, mean HbA1c 6.9% and 22 matched control subjects. No colonic pathology was apparent in these subjects at routine gastrointestinal investigations. Results Mean colonic epithelial telomere length in the diabetes group was not significantly different from controls (10.6 [3.6] vs. 12.1 [3.4] Molecular Equivalent of Soluble Fluorochrome Units [MESF]; P = 0.5. Levels of oxidative DNA damage were similar in both T2DM and control groups (2.6 [0.6] vs. 2.5 [0.6] Mean Fluorescent Intensity [MFI]; P = 0.7. There was no significant relationship between oxidative DNA damage and telomere length in either group (both p > 0.1. Conclusion Colonic epithelium in Type 2 diabetes does not differ significantly from control colonic epithelium in oxidative DNA damage or telomere length. There is no evidence in this study for increased oxidative DNA damage or significant telomere attrition in colonic mucosa as a carcinogenic mechanism.
Rota, Viviana; Perucca, Laura; Simone, Anna; Tesio, Luigi
2011-01-01
In healthy adults, the step length/cadence ratio [walk ratio (WR) in mm/(steps/min) and normalized for height] is known to be constant around 6.5 mm/(step/min). It is a speed-independent index of the overall neuromotor gait control, in as much as it reflects energy expenditure, balance, between-step variability, and attentional demand. The speed…
Mikko Niilo-Rämä
2014-06-01
Full Text Available A novel estimator for estimating the mean length of fibres is proposed for censored data observed in square shaped windows. Instead of observing the fibre lengths, we observe the ratio between the intensity estimates of minus-sampling and plus-sampling. It is well-known that both intensity estimators are biased. In the current work, we derive the ratio of these biases as a function of the mean length assuming a Boolean line segment model with exponentially distributed lengths and uniformly distributed directions. Having the observed ratio of the intensity estimators, the inverse of the derived function is suggested as a new estimator for the mean length. For this estimator, an approximation of its variance is derived. The accuracies of the approximations are evaluated by means of simulation experiments. The novel method is compared to other methods and applied to real-world industrial data from nanocellulose crystalline.
Materials for intraocular lenses enabling photo-controlled tuning of focal length in vivo
Träger, Jens; Heinzer, Jasmin; Kim, Hee-Cheol; Hampp, Norbert
2007-07-01
Typical postoperative complications in cataract surgery are that refractive power and curvature of the implanted intraocular lens (IOL) do not have optimum values, requiring the patient to wear viewing aids. This is mainly because biometric data relevant for calculation of the IOL's shape cannot be determined with the required precision. Hence, there is a need for methods to tune the focal length postoperatively in a non-invasive manner. We have developed polymers where we can induce a change in refractive index by linking or cleaving bonds between a su.ciently large number of side groups of the polymer main chain in a photoinduced cycloaddition or cycloreversion reaction, respectively. These photoreactions lead to a change in refractive index great enough to be interesting for the concept of in vivo tunable IOL's. The photochemical reaction can be triggered by a two-photon process (TPA) using a pulsed laser system, i.e. the energy required for bond breaking is provided by two photons in the visible range. This is important because light in the UV cannot induce undesired changes of the refractive index owing to the strong UV-absorption of the cornea. Undesired changes due to light in the visible range of the spectrum are unlikely to happen because photon density of sun light is much too low for TPA. Due to the excellent spatial resolution that can be achieved with two-photon processes one cannot only modify the refractive index of the entire lens but also selectively in well defined areas enabling to correct for aberrations such as astigmatism. Here, we present new polymers that do not only exhibit a photo induced change of refractive index great enough to induce a change of focal length of more than two diopters in a standard IOL. These new polymers have also significantly improved material properties with respect to the fabrication of the IOL and the TPA-sensitivities and the light energy required to induce the refractive index change.
Frantziskonis, George N.; Gur, Sourav
2017-06-01
Thermally induced phase transformation in NiTi shape memory alloys (SMAs) shows strong size and shape, collectively termed length scale effects, at the nano to micrometer scales, and that has important implications for the design and use of devices and structures at such scales. This paper, based on a recently developed multiscale model that utilizes molecular dynamics (MDs) simulations at small scales and MD-verified phase field (PhF) simulations at larger scales, reports results on specific length scale effects, i.e. length scale effects in martensite phase fraction (MPF) evolution, transformation temperatures (martensite and austenite start and finish) and in the thermally cyclic transformation between austenitic and martensitic phase. The multiscale study identifies saturation points for length scale effects and studies, for the first time, the length scale effect on the kinetics (i.e. developed internal strains) in the B19‧ phase during phase transformation. The major part of the work addresses small scale single crystals in specific orientations. However, the multiscale method is used in a unique and novel way to indirectly study length scale and grain size effects on evolution kinetics in polycrystalline NiTi, and to compare the simulation results to experiments. The interplay of the grain size and the length scale effect on the thermally induced MPF evolution is also shown in this present study. Finally, the multiscale coupling results are employed to improve phenomenological material models for NiTi SMA.
Li, X Y; Yang, G W; Zheng, D S; Guo, W S; Hung, W N N
2015-01-01
Genetic regulatory networks are the key to understanding biochemical systems. One condition of the genetic regulatory network under different living environments can be modeled as a synchronous Boolean network. The attractors of these Boolean networks will help biologists to identify determinant and stable factors. Existing methods identify attractors based on a random initial state or the entire state simultaneously. They cannot identify the fixed length attractors directly. The complexity of including time increases exponentially with respect to the attractor number and length of attractors. This study used the bounded model checking to quickly locate fixed length attractors. Based on the SAT solver, we propose a new algorithm for efficiently computing the fixed length attractors, which is more suitable for large Boolean networks and numerous attractors' networks. After comparison using the tool BooleNet, empirical experiments involving biochemical systems demonstrated the feasibility and efficiency of our approach.
Modeling of a Variable Focal Length Flat Lens Using Left Handed Metamaterials
Reinert, Jason
2004-01-01
Left Handed Metamaterials (LHM) were originally purposed by Victor Veselago in1968. These substances would allow a flat structure to focus electromagnetic (EM) waves because they have a negative index of refraction. A similar structure made from conventional materials, those with a positive index of refraction, would disperse the waves. But until recently, these structures have been purely theoretical because substances with both a negative permittivity and negative permeability, material properties necessary for a negative index of refraction, do not naturally exist, Recent developments have produced a structure composed of an array of thin wires and split ring resonators that shows a negative index of refraction. area smaller than a square wavelength. How small the area is can be determined by how perfectly the lens is polished and how pure the substance is that composes the lens. These lenses must also be curved for focusing to occur. The focal length is determined by the curvature of the lens and the material. On the other hand, a flat structure made from LHM would focus light because of the effect of a negative index of refraction in Snell s law. The focal length could also be varied by simply adjusting the distance of the lens from the source of radiation. This could create many devices that are adjustable to different situations in fields such as biomedical imaging and communication. the software package XFDTD which solves Maxwell s equations in the frequency domain as well as the time domain. The program used Drude models of materials to simulate the effect of negative permittivity and negative permeability. Because of this, a LHM can be simulated as a solid block of material instead of an array of wires and split ring resonators. After a flat lens is formed, I am to examine the focusing effect of the lens and determine if a higher resolution flat lens can be developed. Traditional lenses made from conventional materials cannot focus an EM wave onto an My
Combustion Process Modelling and Control
Vladimír Maduda
2007-10-01
Full Text Available This paper deals with realization of combustion control system on programmable logic controllers. Control system design is based on analysis of the current state of combustion control systems in technological device of raw material processing area. Control system design is composed of two subsystems. First subsystem is represented by software system for measured data processing and for data processing from simulation of the combustion mathematical model. Outputs are parameters for setting of controller algorithms. Second subsystem consists from programme modules. The programme module is presented by specific control algorithm, for example proportional regulation, programmed proportional regulation, proportional regulation with correction on the oxygen in waste gas, and so on. According to the specific combustion control requirements it is possible built-up concrete control system by programme modules. The programme modules were programmed by Automation studio that is used for development, debugging and testing software for B&R controllers.
Wind Farms: Modeling and Control
Soleimanzadeh, Maryam
2012-01-01
provides the state space form of the dynamic wind farm model. The model provides an approximation of the behavior of the flow in wind farms, and obtains the wind speed in the vicinity of each wind turbine. The control algorithms in this work are mostly on the basis of the developed wind farm model......The primary purpose of this work is to develop control algorithms for wind farms to optimize the power production and augment the lifetime of wind turbines in wind farms. In this regard, a dynamical model for wind farms was required to be the basis of the controller design. In the first stage......, a dynamical model has been developed for the wind flow in wind farms. The model is based on the spatial discretization of the linearized Navier-Stokes equation combined with the vortex cylinder theory. The spatial discretization of the model is performed using the Finite Difference Method (FDM), which...
Seed-Mediated Growth of Gold Nanorods: Limits of Length to Diameter Ratio Control
Christopher J. Ward
2014-01-01
Full Text Available The effects of the seed reaction conditions on the two-step seed-mediated growth of gold nanorods and the effect of gold and reducing agent content in the growth solution were evaluated. Results indicate that the reaction conditions used to produce the seeds have a significant impact on the aspect ratio of the gold nanorods produced. Increasing the concentration of gold or the reaction temperature in the seed production step results in lower length to diameter (aspect ratio gold rods. In addition, the amount of prepared seed added to the growth solution impacts the rod aspect ratio, with increasing amounts of seed reducing the aspect ratio. The effects of reducing agent, ascorbic acid (AA, and gold content of the growth solution on the aspect ratio of the produced rods are strongly interrelated. There exists a minimum ascorbic acid to gold concentration below which rods will not form; however, increasing the ratio above this minimum results in shorter rods being formed. Characterization of nanorod growth is performed by UV-vis-NIR spectrophotometry and transmission electron microscopy (TEM.
McGuinness, Kenneth; Khan, I John; Nanda, Vikas
2014-12-23
Synthetic collagen mimetic peptides are used to probe the role of hydrophobic forces in mediating protein self-assembly. Higher order association is an integral property of natural collagens, which assemble into fibers and meshes that comprise the extracellular matrix of connective tissues. The unique triple-helix fold fully exposes two-thirds of positions in the protein to solvent, providing ample opportunities for engineering interaction sites. Inclusion of just a few hydrophobic groups in a minimal peptide promotes a rich variety of self-assembly behaviors, resulting in hundred-nanometer to micron size nanodiscs and nanofibers. Morphology depends primarily on the length of hydrophobic domains. Peptide discs contain lipophilic domains capable of sequestering small hydrophobic dyes. Combining multiple peptide types result in composite structures of discs and fibers ranging from stars to plates-on-a-string. These systems provide valuable tools to shed insight into the fundamental principles underlying hydrophobicity-driven higher order protein association that will facilitate the design of self-assembling systems in biomaterials and nanomedical applications.
Han, Sang Eon
2016-02-08
Nanostructured metals have been intensively studied for optical applications over the past few decades. However, the intrinsic loss of metals has limited the optical performance of the metal nanostructures in diverse applications. In particular, light concentration in metals by surface plasmons or other resonances causes substantial absorption in metals. Here, we avoid plasmonic excitations for low loss and investigate methods to further suppress loss in nanostructured metals. We demonstrate that parasitic absorption in metal nanostructures can be significantly reduced over a broad band by increasing the Faraday inductance and the electron path length. For an example structure, the loss is reduced in comparison to flat films by more than an order of magnitude over most of the very broad spectrum between short and long wavelength infrared. For a photodetector structure, the fraction of absorption in the photoactive material increases by two orders of magnitude and the photoresponsivity increases by 15 times because of the selective suppression of metal absorption. These findings could benefit many metal-based applications that require low loss such as photovoltaics, photoconductive detectors, solar selective surfaces, infrared-transparent defrosting windows, and other metamaterials.
ZHONG Yi-feng; WANG Rui; YING Xue-gang; CHEN Huai
2006-01-01
In this paper, we established a finite element (FEM) model to analyze the dynamic characteristics of arch bridges. In this model, the effects of adjustment to the length of a suspender on its geometry stiffness matrix are stressed. The FEM equations of mechanics characteristics, natural frequency and main mode are set up based on the first order matrix perturbation theory. Applicantion of the proposed model to analyze a real arch bridge proved the improvement in the simulation precision of dynamical characteristics of the arch bridge by considering the effects of suspender length variation.
Optimal smoothing length scale for actuator line models of lifting surfaces
Martinez-Tossas, Luis A
2015-01-01
The actuator line model (ALM) is a commonly used method to represent lifting surfaces such as wind turbine blades within Large-Eddy Simulations (LES). In ALM the lift and drag forces are replaced by an imposed body force which is typically smoothed over several grid points using a Gaussian kernel with some prescribed smoothing width $\\epsilon$. To date, the choice of $\\epsilon$ has most often been based on numerical considerations mostly related to the grid spacing used in LES. However, especially for finely resolved LES with grid spacings on the order or smaller than the chord-length of the blade, the best choice of $\\epsilon$ is not known. Focusing first on the lift force, here we find $\\epsilon$ and the force center location that minimize the square difference between the velocity fields obtained from solving 2D potential flow over Joukowski airfoils and solving the Euler equations including the imposed body force. The latter solution is found for the linearized problem, and is valid for small angles of at...
Multiple Model Approaches to Modelling and Control,
Why Multiple Models?This book presents a variety of approaches which produce complex models or controllers by piecing together a number of simpler subsystems. Thisdivide-and-conquer strategy is a long-standing and general way of copingwith complexity in engineering systems, nature and human probl...
Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.
Phang, Juanita M; Harrop, Stephen J; Duff, Anthony P; Sokolova, Anna V; Crossett, Ben; Walsh, James C; Beckham, Simone A; Nguyen, Cuong D; Davies, Roberta B; Glöckner, Carina; Bromley, Elizabeth H C; Wilk, Krystyna E; Curmi, Paul M G
2016-09-15
Ezrin is a member of the ERM (ezrin-radixin-moesin) family of proteins that have been conserved through metazoan evolution. These proteins have dormant and active forms, where the latter links the actin cytoskeleton to membranes. ERM proteins have three domains: an N-terminal FERM [band Four-point-one (4.1) ERM] domain comprising three subdomains (F1, F2, and F3); a helical domain; and a C-terminal actin-binding domain. In the dormant form, FERM and C-terminal domains form a stable complex. We have determined crystal structures of the active FERM domain and the dormant FERM:C-terminal domain complex of human ezrin. We observe a bistable array of phenylalanine residues in the core of subdomain F3 that is mobile in the active form and locked in the dormant form. As subdomain F3 is pivotal in binding membrane proteins and phospholipids, these transitions may facilitate activation and signaling. Full-length ezrin forms stable monomers and dimers. We used small-angle X-ray scattering to determine the solution structures of these species. As expected, the monomer shows a globular domain with a protruding helical coiled coil. The dimer shows an elongated dumbbell structure that is twice as long as the monomer. By aligning ERM sequences spanning metazoan evolution, we show that the central helical region is conserved, preserving the heptad repeat. Using this, we have built a dimer model where each monomer forms half of an elongated antiparallel coiled coil with domain-swapped FERM:C-terminal domain complexes at each end. The model suggests that ERM dimers may bind to actin in a parallel fashion.
Khajueenejad, F.; Ghanbari, J.
2015-10-01
The internal length parameter of the modified couple stress theory for single walled carbon nanotubes (CNTs) is determined in this paper. Buckling of CNTs have been studied using Timoshenko beam model and modified couple stress theory. The governing equations for three different end conditions, simple-simple, clamped-clamped and clamped-free, are solved using variational methods and an exact solution is provided for the buckling load. The effects of the internal length parameter on the buckling load of various CNT length and diameters are studied. It is observed that the internal length parameter has larger influence on the higher modes of buckling and for shorter nanotubes. A method presented to obtain the internal length parameter of higher order theories. By correlating the obtained results with the more accurate molecular dynamics simulations, the internal length parameter has been calculated for zigzag and armchair nanotubes. It is observed that the internal length parameter has slight dependency on the size of the CNTs and an average value is provided.
Synchronization in a Random Length Ring Network for SDN-Controlled Optical TDM Switching
Kamchevska, Valerija; Cristofori, Valentina; Da Ros, Francesco;
2016-01-01
. In addition, we propose a novel synchronization algorithm that enables automatic synchronization of software defined networking controlled all-optical TDM switching nodes connected in a ring network. Besides providing synchronization, the algorithm also can facilitate dynamic slot size change and failure...... multiplexing transmission and switching of data bursts when using the proposed algorithm to provide synchronization....
Probabilistic Models for Estimation of Random and Pseudo—Random Test Length
向东; 魏道政; 等
1992-01-01
A new probabilistic testability measure is presented to ease test length analyses of random testing and pseudorandom testing.The testability measure given in this paper is oriented to signal conflict of reconvergent fanouts.Test length analyses in this paper are based on a hard fault set,calculations of which are practicable and simple.Experimental results have been obtained to show the accuracy of this test length analyser in comparison with that of Savir[6],Chin and McClusker[8],and Wunderlich[4] by using a pseudorandom est generator combined with exhaustive fault simulation.
Magic, Zazralt; Asplund, Martin
2014-01-01
We investigate the relation between 1D atmosphere models that rely on the mixing length theory and models based on full 3D radiative hydrodynamic (RHD) calculations to describe convection in the envelopes of late-type stars. The adiabatic entropy value of the deep convection zone, s_bot, and the entropy jump, {\\Delta}s, determined from the 3D RHD models, are matched with the mixing length parameter, {\\alpha}_MLT, from 1D hydrostatic atmosphere models with identical microphysics (opacities and equation-of-state). We also derive the mass mixing length, {\\alpha}_m, and the vertical correlation length of the vertical velocity, C[v_z,v_z], directly from the 3D hydrodynamical simulations of stellar subsurface convection. The calibrated mixing length parameter for the Sun is {\\alpha}_MLT (s_bot) = 1.98. For different stellar parameters, {\\alpha}_MLT varies systematically in the range of 1.7 - 2.4. In particular, {\\alpha}_MLT decreases towards higher effective temperature, lower surface gravity and higher metallicity...
Surendra Singh; A K Poswal; S K Ghosh; Saibal Basu
2008-11-01
We report the density depth profile of an as-deposited Ni film and density profile for the same film after controlled electrochemical corrosion by chloride ions, measured by unpolarized neutron reflectometry. The neutron reflectometry measurement of the film after corrosion shows density degradation along the thickness of the film. The density profile as a function of depth, maps the growth of pitting and void networks due to corrosion. The profile after corrosion shows an interesting peaking nature.
Sergey V. Buldyrev; Pradeep Kumar; Pablo G. Debenedetti; Peter J. Rossky; H. Eugene Stanley
2007-01-01
We examine by molecular dynamics simulation the solubility of small apolar solutes in a solvent whose particles interact via the Jagla potential, a spherically symmetric ramp potential with two characteristic lengths...
Magic, Z.; Weiss, A.; Asplund, M.
2015-01-01
Aims: We investigate the relation between 1D atmosphere models that rely on the mixing length theory and models based on full 3D radiative hydrodynamic (RHD) calculations to describe convection in the envelopes of late-type stars. Methods: The adiabatic entropy value of the deep convection zone, sbot, and the entropy jump, Δs, determined from the 3D RHD models, were matched with the mixing length parameter, αMLT, from 1D hydrostatic atmosphere models with identical microphysics (opacities and equation-of-state). We also derived the mass mixing length parameter, αm, and the vertical correlation length of the vertical velocity, C[vz,vz], directly from the 3D hydrodynamical simulations of stellar subsurface convection. Results: The calibrated mixing length parameter for the Sun is α๏MLT (Sbot) = 1.98. . For different stellar parameters, αMLT varies systematically in the range of 1.7 - 2.4. In particular, αMLT decreases towards higher effective temperature, lower surface gravity and higher metallicity. We find equivalent results for α๏MLT (ΔS). In addition, we find a tight correlation between the mixing length parameter and the inverse entropy jump. We derive an analytical expression from the hydrodynamic mean-field equations that motivates the relation to the mass mixing length parameter, αm, and find that it qualitatively shows a similar variation with stellar parameter (between 1.6 and 2.4) with the solar value of α๏m = 1.83.. The vertical correlation length scaled with the pressure scale height yields 1.71 for the Sun, but only displays a small systematic variation with stellar parameters, the correlation length slightly increases with Teff. Conclusions: We derive mixing length parameters for various stellar parameters that can be used to replace a constant value. Within any convective envelope, αm and related quantities vary strongly. Our results will help to replace a constant αMLT. Appendices are available in electronic form at http
Kim, Hyungdae; Ahn, Ho Seon; Kwak, Ho Jae; Kim, Moo Hwan; Kim, Dong Eok
2016-12-01
A boiling crisis, or critical heat flux (CHF), is a condition that determines the upper bound on removable thermal energy at a boiling surface. In such situations, the liquid cannot wet the surface because a vapor film completely covers it. CHF is enhanced on micro-structured surfaces when under boiling conditions. CHF values were measured for surfaces with rectangular microchannel geometries of various channel widths, (10-30 μm) and generally increased in value as channel widths decreased. However, the CHF value for the 5-μm channel-width surface was found to be lower than the wider channel-width surfaces. This observation contradicts models based on vapor recoil and classical instability mechanisms. Hence, we present a fluid-dynamics model that considers capillary pumping and viscous friction. With a focus on the spatial distribution of the liquid penetration region and the local dry spot under a large vapor bubble, this model can accurately predict the CHF variation associated with different channel widths.
Multiple Model Approaches to Modelling and Control,
on the ease with which prior knowledge can be incorporated. It is interesting to note that researchers in Control Theory, Neural Networks,Statistics, Artificial Intelligence and Fuzzy Logic have more or less independently developed very similar modelling methods, calling them Local ModelNetworks, Operating...... of introduction of existing knowledge, as well as the ease of model interpretation. This book attempts to outlinemuch of the common ground between the various approaches, encouraging the transfer of ideas.Recent progress in algorithms and analysis is presented, with constructive algorithms for automated model...
KONG Fuquan; ZHAO Kui; ZHAN Yong; CAO Tianguang; NI Meinan; SUI Li; CAI Minghui; ZHUO Yizhong
2005-01-01
Deoxyribonucleic acid (DNA) is an important bio-macromolecule. DNA double strand breaks (DSBs) are considered to be the most important initial damage responsible for all biological effects induced by ionizing radiation. In this paper the length distribution of DNA fragments induced by 7Li ionizing radiation is fitted with the random breakage model. In this model, the parameter u is the average number of DSBs on every DNA molecule induced by ionizing radiation. The fitting result shows that the random breakage model cannot describe the distribution of DNA fragments in lower doses, while the random breakage model is in better accordance with the experimental data in higher doses. It is shown that the length distribution of DNA fragments has random statistical feature in higher doses. In this situation, the random breakage model looks like a model without any parameter since the u has specific physical meaning and can directly be obtained from experimental data.
Jenkins, Bruce G; Andreassen, Ole A; Dedeoglu, Alpaslan; Leavitt, Blair; Hayden, Michael; Borchelt, David; Ross, Christopher A; Ferrante, Robert J; Beal, M Flint
2005-10-01
Huntington's disease is a neurodegenerative illness caused by expansion of CAG repeats at the N-terminal end of the protein huntingtin. We examined longitudinal changes in brain metabolite levels using in vivo magnetic resonance spectroscopy in five different mouse models. There was a large (>50%) exponential decrease in N-acetyl aspartate (NAA) with time in both striatum and cortex in mice with 150 CAG repeats (R6/2 strain). There was a linear decrease restricted to striatum in N171-82Q mice with 82 CAG repeats. Both the exponential and linear decreases of NAA were paralleled in time by decreases in neuronal area measured histologically. Yeast artificial chromosome transgenic mice with 72 CAG repeats, but low expression levels, had less striatal NAA loss than the N171-82Q mice (15% vs. 43%). We evaluated the effect of gene context in mice with an approximate 146 CAG repeat on the hypoxanthine phosphoribosyltransferase gene (HPRT). HPRT mice developed an obese phenotype in contrast to weight loss in the R6/2 and N171-82Q mice. These mice showed a small striatal NAA loss (21%), and a possible increase in brain lipids detectable by magnetic resonance (MR) spectroscopy and decreased brain water T1. Our results indicate profound metabolic defects that are strongly affected by CAG repeat length, as well as gene expression levels and protein context.
Nonlinear Control of Heartbeat Models
Witt Thanom
2011-02-01
Full Text Available This paper presents a novel application of nonlinear control theory to heartbeat models. Existing heartbeat models are investigated and modified by incorporating the control input as a pacemaker to provide the control channel. A nonlinear feedback linearization technique is applied to force the output of the systems to generate artificial electrocardiogram (ECG signal using discrete data as the reference inputs. The synthetic ECG may serve as a flexible signal source to assess the effectiveness of a diagnostic ECG signal-processing device.
Gill, Wonpyong [Pusan National University, Busan (Korea, Republic of)
2010-08-15
The dependence of the crossing time on the sequence length in the coupled and the decoupled continuous-time mutation-selection models in an asymmetric sharply-peaked landscape with a positive asymmetric parameter, r, was examined for a fixed extension parameter, E, which is defined as the average Hamming distance from the optimal allele of the initial quasispecies divided by the sequence length. Two versions of the coupled mutation-selection model, the continuous-time version and discrete-time version, were found to have the same boundary between the deterministic and the stochastic regions, which is different from the boundary between the deterministic and the stochastic regions in the decoupled continuous-time mutation-selection model. The maximum sequence length for a finite population that can evolve through the fitness barrier, e.g., within 10{sup 6} generations in the decoupled continuous-time mutation-selection model, increased by approximately eight sequence elements with increasing population size by a factor of a thousand when E = 0.1 and r = 0.1. The crossing time for a finite population in the decoupled model in the stochastic region was shorter than the crossing time for a finite population in the coupled model, and the maximum evolvable sequence length for a finite population in the decoupled model was longer than the maximum evolvable sequence length for a finite population in the coupled model. This suggests that a mutation allowed at any time during the life cycle might be more effective than a mutation allowed only at reproduction events when a finite population transits to a higher fitness peak through the fitness barrier in an asymmetric sharply-peaked landscape.
Olsen, Morten Tange; Bérubé, Martine; Robbins, Jooke
2012-01-01
BACKGROUND:Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent cri...
Olsen, Morten Tange; Berube, Martine; Robbins, Jooke; Palsboll, Per J.
2012-01-01
Background: Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent criti
Olsen, Morten Tange; Berube, Martine; Robbins, Jooke; Palsboll, Per J.
2012-01-01
Background: Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent criti
Global nuclear material control model
Dreicer, J.S.; Rutherford, D.A.
1996-05-01
The nuclear danger can be reduced by a system for global management, protection, control, and accounting as part of a disposition program for special nuclear materials. The development of an international fissile material management and control regime requires conceptual research supported by an analytical and modeling tool that treats the nuclear fuel cycle as a complete system. Such a tool must represent the fundamental data, information, and capabilities of the fuel cycle including an assessment of the global distribution of military and civilian fissile material inventories, a representation of the proliferation pertinent physical processes, and a framework supportive of national or international perspective. They have developed a prototype global nuclear material management and control systems analysis capability, the Global Nuclear Material Control (GNMC) model. The GNMC model establishes the framework for evaluating the global production, disposition, and safeguards and security requirements for fissile nuclear material.
Modeling the Radar Return of Powerlines Using an Incremental Length Diffraction Coefficient Approach
Macdonald, Douglas
DIRSIG consistently underestimated the scattered return, especially away from specular observation angles. This underestimation was particularly pronounced for the dihedral targets which have a low acceptance angle in elevation, probably caused by the lack of a physical optics capability in DIRSIG. Powerlines were not apparent in the simulated data. For modeling powerlines outside of DIRSIG using a standalone approach, an Incremental Length Diffraction Coefficient (ILDC) method was used. Traditionally, this method is used to model the scattered radiation from the edge of a wedge, for example the edges on the wings of a stealth aircraft. The Physical Theory of Diffraction provides the 2D diffraction coefficient and the ILDC method performs an integral along the edge to extend this solution to three dimensions. This research takes the ILDC approach but instead of using the wedge diffraction coefficient, the exact far-field diffraction coefficient for scattering from a finite length cylinder is used. Wavenumber-diameter products are limited to less than or about 10. For typical powerline diameters, this translates to X-band frequencies and lower. The advantage of this method is it allows exact 2D solutions to be extended to powerline geometries where sag is present and it is shown to be more accurate than a pure physical optics approach for frequencies lower than millimeter wave. The Radar Cross Sections produced by this method were accurate to within the experimental uncertainty of measured RF anechoic chamber data for both X and C-band frequencies across an 80 degree arc for 5 different target types and diameters. For the X-band data, the mean error was 6.0% for data with 9.5% measurement uncertainty. For the C-band data, the mean error was 11.8% for data with 14.3% measurement uncertainty. The best results were obtained for X-band data in the HH polarization channel within a 20 degree arc about normal incidence. For this configuration, a mean error of 3.0% for data with
The impact of voluntary exercise on relative telomere length in a rat model of developmental stress
Botha Martmari
2012-12-01
Full Text Available Abstract Background Exposure to early adverse events can result in the development of later psychopathology, and is often associated with cognitive impairment. This may be due to accelerated cell aging, which can be catalogued by attritioned telomeres. Exercise enhances neurogenesis and has been proposed to buffer the effect of psychological stress on telomere length. This study aimed to investigate the impact of early developmental stress and voluntary exercise on telomere length in the ventral hippocampus (VH and prefrontal cortex (PFC of the rat. Forty-five male Sprague–Dawley rats were categorised into four groups: maternally separated runners (MSR, maternally separated non-runners (MSnR, non-maternally separated runners (nMSR and non-maternally separated non-runners (nMSnR. Behavioural analyses were conducted to assess anxiety-like behaviour and memory performance in the rats, after which relative telomere length was measured using qPCR. Results Maternally separated (MS rats exhibited no significant differences in either anxiety levels or memory performance on the elevated-plus maze and the open field compared to non-maternally separated rats at 49 days of age. Exercised rats displayed increased levels of anxiety on the day that they were removed from the cages with attached running wheels, as well as improved spatial learning and temporal recognition memory compared to non-exercised rats. Exploratory post-hoc analyses revealed that maternally separated non-exercised rats exhibited significantly longer telomere length in the VH compared to those who were not maternally separated; however, exercise appeared to cancel this effect since there was no difference in VH telomere length between maternally separated and non-maternally separated runners. Conclusions The increased telomere length in the VH of maternally separated non-exercised rats may be indicative of reduced cellular proliferation, which could, in turn, indicate hippocampal
Modelling on fuzzy control systems
LI; Hongxing(李洪兴); WANG; Jiayin(王加银); MIAO; Zhihong(苗志宏)
2002-01-01
A kind of modelling method for fuzzy control systems is first proposed here, which is calledmodelling method based on fuzzy inference (MMFI). It should be regarded as the third modelling method thatis different from two well-known modelling methods, that is, the first modelling method, mechanism modellingmethod (MMM), and the second modelling method, system identification modelling method (SlMM). Thismethod can, based on the interpolation mechanism on fuzzy logic system, transfer a group of fuzzy inferencerules describing a practice system into a kind of nonlinear differential equation with variable coefficients, calledHX equations, so that the mathematical model of the system can be obtained. This means that we solve thedifficult problem of how to get a model represented as differential equations on a complicated or fuzzy controlsystem.
Noda, Yuta; Hayakawa, Tomokatsu
2016-10-01
Triangular gold (Au) nanoprisms of various sizes were synthesized in a controlled way using a modified three-step seed-mediated method with different volumes of starting seed solution and subsequent first step's growth solution. The structures and optical properties of the triangular Au nanoprisms were investigated using transmission electron microscopy (TEM), atomic force microscopy, and UV-Vis-NIR spectrophotometry. The Au nanoprisms synthesized also varied in optical response frequency of localized surface plasmon resonance (LSPR) owing to electric dipole polarizations of the Au nanoprisms. This variation depended nonlinearly on the volume of the seed solution. From optical extinction spectra and careful TEM observations, the dipole LSPR peak frequency was found to be linearly proportional to the edge length of the Au nanoprisms. Consequently, it was experimentally shown that the LSPR optical response frequency of their colloidal solutions could be controlled in the near-infrared region (700-1200 nm), corresponding to an edge length of 40-180 nm of the Au nanoprisms. It was also demonstrated that the tip sharpness of triangular Au nanoprisms was improved by using fine Au seeds instead of coarse Au seeds, and the resulting Au nanoprisms were smaller and thinner. A formation mechanism of triangular Au nanoprisms shall also be discussed with a prospect of synthesizing very tiny Au nanoprisms.
Hu, Huiqing; Zhou, Qing; Li, Ziyin
2015-12-18
The evolutionarily conserved centriole/basal body protein SAS-4 regulates centriole duplication in metazoa and basal body duplication in flagellated and ciliated organisms. Here, we report that the SAS-4 homolog in the flagellated protozoan Trypanosoma brucei, TbSAS-4, plays an unusual role in controlling life cycle transitions by regulating the length of the flagellum attachment zone (FAZ) filament, a specialized cytoskeletal structure required for flagellum adhesion and cell morphogenesis. TbSAS-4 is concentrated at the distal tip of the FAZ filament, and depletion of TbSAS-4 in the trypomastigote form disrupts the elongation of the new FAZ filament, generating cells with a shorter FAZ associated with a longer unattached flagellum and repositioned kinetoplast and basal body, reminiscent of epimastigote-like morphology. Further, we show that TbSAS-4 associates with six additional FAZ tip proteins, and depletion of TbSAS-4 disrupts the enrichment of these FAZ tip proteins at the new FAZ tip, suggesting a role of TbSAS-4 in maintaining the integrity of this FAZ tip protein complex. Together, these results uncover a novel function of TbSAS-4 in regulating the length of the FAZ filament to control basal body positioning and life cycle transitions in T. brucei.
Sujatha Kabilan
2012-01-01
Full Text Available Controlled drug delivery technology represents one of the most rapidly advancing areas of science. They offer numerous advantages compared to conventional dosage forms including improved efficacy, reduced toxicity, improved patient compliance and convenience. Over the past several decades, many delivery tools or methods were developed such as viral vector, liposome-based delivery system, polymer-based delivery system, and intelligent delivery system. Recently, nonviral vectors, especially those based on biodegradable polymers, have been widely investigated as vectors. Unlike the other polymers tested, polyhydroxyalkanoates (PHAs have been intensively investigated as a family of biodegradable and biocompatible materials for in vivo applications as implantable tissue engineering material as well as release vectors for various drugs. On the other hand, the direct use of these polyesters has been hampered by their hydrophobic character and some physical shortcomings, while its random copolymers fulfilled the expectation of biomedical researchers by exhibiting significant mechanical and thermal properties. This paper reviews the strategies adapted to make functional polymer to be utilized as delivery system.
Novel constant linear velocity control method for the multilevel run-length limited read-only disc
Yan, Mingming; Pei, Jing; Pan, Longfa; Wang, Hequn
2009-08-01
A novel constant linear velocity (CLV) control method employing sync pattern detection has been developed for the multi-level run-length limited read-only disc. In the proposed method, the sync pattern is special designed and inserted in the RF signal to detect the velocity error of the spindle. The differentiation method is adopted to detect the sync pattern from the RF signal and is more easy and accurate than using the threshold level slicer. By using the proposed CLV method, the spindle works robust in the CLV mode and the velocity error of the spindle can be suppressed less than 0.3%. The experimental result shows the novel CLV control method for the ML-RLL read-only disc is practicability.
Ramli, Nazirah; Mutalib, Siti Musleha Ab; Mohamad, Daud
2017-08-01
Fuzzy time series forecasting model has been proposed since 1993 to cater for data in linguistic values. Many improvement and modification have been made to the model such as enhancement on the length of interval and types of fuzzy logical relation. However, most of the improvement models represent the linguistic term in the form of discrete fuzzy sets. In this paper, fuzzy time series model with data in the form of trapezoidal fuzzy numbers and natural partitioning length approach is introduced for predicting the unemployment rate. Two types of fuzzy relations are used in this study which are first order and second order fuzzy relation. This proposed model can produce the forecasted values under different degree of confidence.
Definition of the persistence length in the coarse-grained models of DNA elasticity
Fathizadeh, A.; Eslami-Mossallam, B.; Ejtehadi, M. R.
2012-11-01
By considering the detailed structure of DNA in the base pair level, two possible definitions of the persistence length are compared. One definition is related to the orientation of the terminal base pairs, and the other is based on the vectors which connect two adjacent base pairs at each end of the molecule. It is shown that although these definitions approach each other for long DNA molecules, they are dramatically different on short length scales. We show analytically that the difference mostly comes from the shear flexibility of the molecule and can be used to measure the shear modulus of DNA.
Hot Strip Laminar Cooling Control Model
WANG Jun; WANG Guo-dong; LIU Xiang-hua
2004-01-01
The control model of laminar cooling system for hot strip, including air-cooling model, water-cooling model, temperature distribution model along thickness direction, feedforward control model, feedback control model and self-learning model, was introduced. PID arithmetic and Smith predictor controller were applied to feedback control. The sample of model parameter classification was given. The calculation process was shown by flow chart. The model has been proved to be simple, effective and of high precision.
Yucesoy, Can A.; Koopman, Bart H.F.J.M.; Grootenboer, Henk J.; Huijing, Peter A.
2007-01-01
Finite element modeling of aponeurotomized rat extensor digitorium longus muscle was performed to investigate the acute effects of proximal aponeurotomy. The specific goal was to assess the changes in lengths of sarcomeres within aponeurotomized muscle and to explain how the intervention leads to al
Zheng, D.; Velde, van der R.; Su, Z.; Booij, M.J.; Hoekstra, A.Y.; Wen, J.
2014-01-01
Current land surface models still have difficulties with producing reliable surface heat fluxes and skin temperature (Tsfc) estimates for high-altitude regions, which may be addressed via adequate parameterization of the roughness lengths for momentum (z0m) and heat (z0h) transfer. In this study, th
Yucesoy, C.A.; Koopman, Hubertus F.J.M.; Grootenboer, H.J.; Huijing, P.A.J.B.M.
2007-01-01
Finite element modeling of aponeurotomized rat extensor digitorium longus muscle was performed to investigate the acute effects of proximal aponeurotomy. The specific goal was to assess the changes in lengths of sarcomeres within aponeurotomized muscle and to explain how the intervention leads to
Du, Jiangbo; Xue, Wenjie; Ji, Yong; Zhu, Xun; Gu, Yayun; Zhu, Meng; Wang, Cheng; Gao, Yong; Dai, Juncheng; Ma, Hongxia; Jiang, Yue; Chen, Jiaping; Hu, Zhibin; Jin, Guangfu; Shen, Hongbing
2015-12-01
Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma (ESCC) was still uncertain. Several telomere length-related single nucleotide polymorphisms (TLSNPs) in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study (1045 ESCC cases and 1433 controls) to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length (RTL) (median: 1.34) than controls (median: 1.50, P telomeres may be risk factors for ESCC in the Chinese population.
Influence of Point Count Length and Repeated Visits on Habitat Model Performance
Randy Dettmers; David A. Buehler; John G. Bartlett; Nathan A. Klaus
1999-01-01
Point counts are commonly used to monitor bird populations, and a substantial amount of research has investigated how conducting counts for different lengths of time affects the accuracy of these counts and the subsequent ability to monitor changes in population trends. However, little work has been done io assess how changes in count duration affect bird-habitat...
Haver, Vincent G.; Mateo Leach, Irene; Kjekshus, John; Fox, Jayne C.; Wedel, Hans; Wikstrand, John; de Boer, Rudolf A.; van Gilst, Wiek H.; McMurray, John J. V.; van Veldhuisen, Dirk J.; van der Harst, Pim
2015-01-01
AIMS: Leucocyte telomere length is considered a marker of biological ageing and has been suggested to be shorter in patients with CAD and heart failure compared with healthy controls. The aim of this study was to determine whether telomere length is associated with clinical outcomes in patients with
Kreugel, Gillian; Keers, Joost C.; Kerstens, Michiel N.; Wolffenbuttel, Bruce H. R.
2011-01-01
Objective: This study determined the influence of needle length for insulin administration on metabolic control and patient preference in obese patients with diabetes mellitus. Methods: In this multicenter, open-label crossover study, insulin pen needles of two different lengths (5 mm and 8 mm) were
Neergaard, Jesper; Schieber, Jay D.
1999-01-01
A self-consistent reptation model that includes chain stretching, chain-length fluctuations, segment connectivity and constraint release is used to predict transient and steady flows. Quantitative comparisons are made with entangledsolution data. The model is able to capture quantitatively all fe...... for differentmolecular weight, the transient and steady-state behavior of the extinction angle, and the stress relaxation in cessation of steady shear flow....
MacKinnon, D.J.; Clow, G.D.; Tigges, R.K.; Reynolds, R.L.; Chavez, P.S.
2004-01-01
The vulnerability of dryland surfaces to wind erosion depends importantly on the absence or the presence and character of surface roughness elements, such as plants, clasts, and topographic irregularities that diminish wind speed near the surface. A model for the friction velocity ratio has been developed to account for wind sheltering by many different types of co-existing roughness elements. Such conditions typify a monitored area in the central Mojave Desert, California, that experiences frequent sand movement and dust emission. Two additional models are used to convert the friction velocity ratio to the surface roughness length (zo) for momentum. To calculate roughness lengths from these models, measurements were made at 11 sites within the monitored area to characterize the surface roughness element. Measurements included (1) the number of roughness species (e.g., plants, small-scale topography, clasts), and their associated heights and widths, (2) spacing among species, and (3) vegetation porosity (a measurement of the spatial distribution of woody elements of a plant). Documented or estimated values of drag coefficients for different species were included in the modeling. At these sites, wind-speed profiles were measured during periods of neutral atmospheric stability using three 9-m towers with three or four calibrated anemometers on each. Modeled roughness lengths show a close correspondence (correlation coefficient, 0.84-0.86) to the aerodynamically determined values at the field sites. The geometric properties of the roughness elements in the model are amenable to measurement at much higher temporal and spatial resolutions using remote-sensing techniques than can be accomplished through laborious ground-based methods. A remote-sensing approach to acquire values of the modeled roughness length is particularly important for the development of linked surface/atmosphere wind-erosion models sensitive to climate variability and land-use changes in areas such
Thevis, Mario; Thomas, Andreas; Geyer, Hans; Schänzer, Wilhelm
2014-12-01
Since Goldspink and colleagues identified the expression of the mRNA of an insulin-like growth factor 1 (IGF-1) isoform in response to mechanical stress in 1996, substantial research into the so-called mechano growth factor and its modus operandi followed until today. Promising preclinical results were obtained by using the synthetic, 24-amino acid residues spanning peptide translated from the exons 4-6 of IGF-1Ec (which was later referred to as the mechano growth factor (MGF) peptide), particularly with regard to increased muscle myoblast proliferation. Consequently, the MGF peptide represented a promising drug candidate for the treatment of neuromuscular disorders; however, its misuse potential in sport was also identified shortly thereafter, and the substance (or class of substances) has been considered prohibited according to the regulations of the World Anti-Doping Agency (WADA) since 2005. While various MGF peptide versions have been known to sports drug testing authorities, the occurrence of a 'full-length MGF' as offered via illicit channels to athletes or athletes' managers was reported in 2014, arguably being undetectable in doping controls. An aliquot of the product was obtained and the content characterized by state-of-the-art analytical approaches including gel electrophoretic and mass spectrometric (top-down and bottom-up) sequencing approaches. Upon full characterization, its implementation into modified routine doping controls using ultrafiltration, immunoaffinity-based isolation, and nanoliquid chromatography-high resolution/high accuracy mass spectrometry was established. A protein with a monoisotopic molecular mass of 12264.9 Da and a sequence closely related to IGF-1Ec (lacking the signal- and propeptide moiety) was identified. The C-terminus was found to be modified by the elimination of the terminal lysine and a R109H substitution. With the knowledge of the compound's composition, existing doping control assays targeting peptide hormones such
Lubna Nasir
2001-01-01
Full Text Available Studies on telomere and telomerase biology are fundamental to the understanding of aging and age-related diseases such as cancer. However, human studies have been hindered by differences in telomere biology between humans and the classical murine animal model system. In this paper, we describe basic studies of telomere length and telomerase activity in canine normal and neoplastic tissues and propose the dog as an alternative model system. Briefly, telomere lengths were measured in normal canine peripheral blood mononuclear cells (PBMCs, a range of normal canine tissues, and in a panel of naturally occurring soft tissue tumours by terminal restriction fragment (TRF analysis. Further, telomerase activity was measured in canine cell lines and multiple canine tissues using a combined polymerase chain reaction/enzyme-linked immunosorbent assay method. TRF analysis in canine PBMCs and tissues demonstrated mean TRF lengths to range between 12 and 23 kbp with heterogeneity in telomere lengths being observed in a range of normal somatic tissues. In soft tissue sarcomas, two subgroups were identified with mean TRFs of 22.2 and 18.2 kbp. Telomerase activity in canine tissue was present in tumour tissue and testis with little or no activity in normal somatic tissues. These results suggest that the dog telomere biology is similar to that in humans and may represent an alternative model system for studying telomere biology and telomerase-targeted anticancer therapies.
Numerical evaluation of the phase-field model for brittle fracture with emphasis on the length scale
Zhang, Xue; Vignes, Chet; Sloan, Scott W.; Sheng, Daichao
2017-05-01
The phase-field model has been attracting considerable attention due to its capability of capturing complex crack propagations without mesh dependence. However, its validation studies have primarily focused on the ability to predict reasonable, sharply defined crack paths. Very limited works have so far been contributed to estimate its accuracy in predicting force responses, which is majorly attributed to the difficulty in the determination of the length scale. Indeed, accurate crack path simulation can be achieved by setting the length scale to be sufficiently small, whereas a very small length scale may lead to unrealistic force-displacement responses and overestimate critical structural loads. This paper aims to provide a critical numerical investigation of the accuracy of phase-field modelling of brittle fracture with special emphasis on a possible formula for the length scale estimation. Phase-field simulations of a number of classical fracture experiments for brittle fracture in concretes are performed with simulated results compared with experimental data qualitatively and quantitatively to achieve this goal. Furthermore, discussions are conducted with the aim to provide guidelines for the application of the phase-field model.
David E Vrech
Full Text Available There is strong evidence that polyandrous taxa have evolved relatively larger testes than monogamous relatives. Sperm size may either increase or decrease across species with the risk or intensity of sperm competition. Scorpions represent an ancient direct mode with spermatophore-mediated sperm transfer and are particularly well suited for studies in sperm competition. This work aims to analyze for the first time the variables affecting testes mass, ejaculate volume and sperm length, according with their levels of polyandry, in species belonging to the Neotropical family Bothriuridae. Variables influencing testes mass and sperm length were obtained by model selection analysis using corrected Akaike Information Criterion. Testes mass varied greatly among the seven species analyzed, ranging from 1.6 ± 1.1 mg in Timogenes dorbignyi to 16.3 ± 4.5 mg in Brachistosternus pentheri with an average of 8.4 ± 5.0 mg in all the species. The relationship between testes mass and body mass was not significant. Body allocation in testes mass, taken as Gonadosomatic Index, was high in Bothriurus cordubensis and Brachistosternus ferrugineus and low in Timogenes species. The best-fitting model for testes mass considered only polyandry as predictor with a positive influence. Model selection showed that body mass influenced sperm length negatively but after correcting for body mass, none of the variables analyzed explained sperm length. Both body mass and testes mass influenced spermatophore volume positively. There was a strong phylogenetic effect on the model containing testes mass. As predicted by the sperm competition theory and according to what happens in other arthropods, testes mass increased in species with higher levels of sperm competition, and influenced positively spermatophore volume, but data was not conclusive for sperm length.
Vrech, David E; Olivero, Paola A; Mattoni, Camilo I; Peretti, Alfredo V
2014-01-01
There is strong evidence that polyandrous taxa have evolved relatively larger testes than monogamous relatives. Sperm size may either increase or decrease across species with the risk or intensity of sperm competition. Scorpions represent an ancient direct mode with spermatophore-mediated sperm transfer and are particularly well suited for studies in sperm competition. This work aims to analyze for the first time the variables affecting testes mass, ejaculate volume and sperm length, according with their levels of polyandry, in species belonging to the Neotropical family Bothriuridae. Variables influencing testes mass and sperm length were obtained by model selection analysis using corrected Akaike Information Criterion. Testes mass varied greatly among the seven species analyzed, ranging from 1.6 ± 1.1 mg in Timogenes dorbignyi to 16.3 ± 4.5 mg in Brachistosternus pentheri with an average of 8.4 ± 5.0 mg in all the species. The relationship between testes mass and body mass was not significant. Body allocation in testes mass, taken as Gonadosomatic Index, was high in Bothriurus cordubensis and Brachistosternus ferrugineus and low in Timogenes species. The best-fitting model for testes mass considered only polyandry as predictor with a positive influence. Model selection showed that body mass influenced sperm length negatively but after correcting for body mass, none of the variables analyzed explained sperm length. Both body mass and testes mass influenced spermatophore volume positively. There was a strong phylogenetic effect on the model containing testes mass. As predicted by the sperm competition theory and according to what happens in other arthropods, testes mass increased in species with higher levels of sperm competition, and influenced positively spermatophore volume, but data was not conclusive for sperm length.
Johanson, J M; Berger, P J; Tsuruta, S; Misztal, I
2011-01-01
The objective of this research was to estimate genetic parameters for a multiple-trait evaluation of dystocia (DYS), perinatal mortality (PM), birth weight (BWT), and gestation length (GL) in Holsteins. The data included 5,712 calving records collected between 1968 and 2005 from the Iowa State University dairy breeding herd in Ankeny. The incidence of PM was 8.8% and that of DYS 28.8%; mean BWT was 40.5 kg, and GL was 279 d. A threshold-linear animal model included the effects of year, season, sex of calf, parity, sire group, direct genetic, maternal genetic, and maternal permanent environment. Direct heritabilities for DYS, PM, BWT, and GL were 0.11 (0.04), 0.13 (0.05), 0.26 (0.04), and 0.51 (0.05), respectively. Maternal heritabilities were 0.14 (0.04), 0.15 (0.03), 0.08 (0.01), and 0.08 (0.02), for DYS, PM, BWT, and GL, respectively. The heritabilities are the posterior means of the Gibbs samples with their standard deviations in parentheses. The direct genetic correlation between PM and DYS was estimated at 0.67 (0.19), whereas the maternal genetic correlation was 0.45 (0.16). Direct and maternal PM and DYS are partially controlled by the same genes. Selection on only calving ease is not sufficient to control PM. With moderate genetic correlations between all 4 traits, BWT and GL should be included with DYS and PM in an evaluation of calving performance.
Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model
Nikolajsen, Gitte; Jensen, Morten Skovgaard; West, Mark J.
2011-01-01
Modern stereological techniques have been used to show that the total length of the cholinergic fibers in the cerebral cortex of the APPswe/PS1deltaE9 mouse is reduced by almost 300 meters at 18 months of age and has a nonlinear relationship to the amount of transgenetically-induced amyloidosis. ....... These data provide rigorous quantitative morphological evidence that Alzheimer's-like amyloidosis affects the axons of the cholinergic enervation of the cerebral cortex....
Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model
Nikolajsen, Gitte; Jensen, Morten Skovgaard; West, Mark J.
2011-01-01
Modern stereological techniques have been used to show that the total length of the cholinergic fibers in the cerebral cortex of the APPswe/PS1deltaE9 mouse is reduced by almost 300 meters at 18 months of age and has a nonlinear relationship to the amount of transgenetically-induced amyloidosis. ....... These data provide rigorous quantitative morphological evidence that Alzheimer's-like amyloidosis affects the axons of the cholinergic enervation of the cerebral cortex....
The Control System Modeling Language
Zagar, K; Sekoranja, M; Tkacik, G; Vodovnik, A; Zagar, Klemen; Plesko, Mark; Sekoranja, Matej; Tkacik, Gasper; Vodovnik, Anze
2001-01-01
The well-known Unified Modeling Language (UML) describes software entities, such as interfaces, classes, operations and attributes, as well as relationships among them, e.g. inheritance, containment and dependency. The power of UML lies in Computer Aided Software Engineering (CASE) tools such as Rational Rose, which are also capable of generating software structures from visual object definitions and relations. UML also allows add-ons that define specific structures and patterns in order to steer and automate the design process. We have developed an add-on called Control System Modeling Language (CSML). It introduces entities and relationships that we know from control systems, such as "property" representing a single controllable point/channel, or an "event" specifying that a device is capable of notifying its clients through events. Entities can also possess CSML-specific characteristics, such as physical units and valid ranges for input parameters. CSML is independent of any specific language or technology...
Evaluation of a Two-Length Scale Turbulence Model with Experiments on Shock-Driven Turbulent Mixing
Carter, John; Gore, Rob; Ranjan, Devesh
2015-11-01
A new second moment turbulence model which uses separate transport and decay length scales is used to model the shock-driven instability. The ability of the model to capture the evolution of turbulence statistics and mixing is discussed. Evaluation is based on comparison to the Georgia Tech shock tube experiments. In the experiments a membraneless light-over-heavy interface is created. There is a long-wavelength perturbation which exists due to inclination of the entire shock tube. By limiting calculations to one dimension, there is not a geometric description of the incline, and the ability of the transport length scale alone to capture the effect of the long-wavelength perturbation is tested.
Mechanics and model-based control of advanced engineering systems
Irschik, Hans; Krommer, Michael
2014-01-01
Mechanics and Model-Based Control of Advanced Engineering Systems collects 32 contributions presented at the International Workshop on Advanced Dynamics and Model Based Control of Structures and Machines, which took place in St. Petersburg, Russia in July 2012. The workshop continued a series of international workshops, which started with a Japan-Austria Joint Workshop on Mechanics and Model Based Control of Smart Materials and Structures and a Russia-Austria Joint Workshop on Advanced Dynamics and Model Based Control of Structures and Machines. In the present volume, 10 full-length papers based on presentations from Russia, 9 from Austria, 8 from Japan, 3 from Italy, one from Germany and one from Taiwan are included, which represent the state of the art in the field of mechanics and model based control, with particular emphasis on the application of advanced structures and machines.
HU Jin-peng; YU Yu-xiu; ZHU Liang-sheng
2006-01-01
Comprehensive 3D model tests and numerical simulation were performed to study the effects of wave obliquity and multidirectionality on the wave forces acting on vertical breakwaters.The variation of wave forces acting on the unit length of a breakwater was analyzed, and the results were compared with Goda's formula.A numerical model based on a short-crest wave system was used to model regular wave forces for practical use, which showed good results for those waves with small incident angles.
Modeling and Controlling Interstate Conflict
Marwala, Tshilidzi
2007-01-01
Bayesian neural networks were used to model the relationship between input parameters, Democracy, Allies, Contingency, Distance, Capability, Dependency and Major Power, and the output parameter which is either peace or conflict. The automatic relevance determination was used to rank the importance of input variables. Control theory approach was used to identify input variables that would give a peaceful outcome. It was found that using all four controllable variables Democracy, Allies, Capability and Dependency; or using only Dependency or only Capabilities avoids all the predicted conflicts.
Rajesh Singh
2016-06-01
Full Text Available In this paper, the failure intensity has been characterized by one parameter length biased exponential class Software Reliability Growth Model (SRGM considering the Poisson process of occurrence of software failures. This proposed length biased exponential class model is a function of parameters namely; total number of failures θ0 and scale parameter θ1. It is assumed that very little or no information is available about both these parameters. The Bayes estimators for parameters θ0 and θ1 have been obtained using non-informative priors for each parameter under square error loss function. The Monte Carlo simulation technique is used to study the performance of proposed Bayes estimators against their corresponding maximum likelihood estimators on the basis of risk efficiencies. It is concluded that both the proposed Bayes estimators of total number of failures and scale parameter perform well for proper choice of execution time.
Koda, Tomonori; Hyodo, Yosuke; Momoi, Yuichi; Kwak, Musun; Kang, Dongwoo; Choi, Youngseok; Nishioka, Akihiro; Haba, Osamu; Yonetake, Koichiro
2016-02-01
In this article, we describe the effects of an anisotropic substrate on the alignment of a nematic liquid crystal. We examine how the substrate affects the alignment of a nematic liquid crystal by Monte Carlo simulation. The liquid crystal on a substrate was described by the phase separation of liquid crystal molecules and substrate molecules, both of which were modeled by hard particles. We used hard rods to represent both the liquid crystal and the substrate. The length of the hard rods representing the substrate was adjusted to represent the degree of substrate anisotropy. The results show that the nematic alignment could either be reinforced or weakened, depending on the length of the substrate rods. Mean field theory is used to analyze the simulation results. We confirmed that the distance over which the substrate affects the bulk liquid crystal is about 3 nm for the present hard-rod-based model.
Udassin, R; Eimerl, D; Schiffman, J; Haskel, Y
1995-05-01
An inverse correlation between postischemic gastrointestinal motility and the length of intestinal ischemia was found in an animal model. Intestinal ischemia was caused without concurrent laparotomy and for a predetermined time period (ischemia time) by pulling on an external nylon thread that was threaded through a double-lumen catheter. This catheter was passed into the abdominal cavity to encircle the superior mesenteric artery. Gastrointestinal motility was determined by the introduction of a color-marked meal into the animal's stomach and the measurement of the proportionate length of the small bowel filled with it (transit index). This simple and reliable animal model can also be used for the evaluation of techniques and pharmacological manipulations aimed at modulation of the effects of intestinal ischemia on intestinal motility and its consequences.
The integrated environmental control model
Rubin, E.S.; Berkenpas, M.B.; Kalagnanam, J.R. [Carnegie Mellon Univ., Pittsburgh, PA (United States)
1995-11-01
The capability to estimate the performance and cost of emission control systems is critical to a variety of planning and analysis requirements faced by utilities, regulators, researchers and analysts in the public and private sectors. The computer model described in this paper has been developed for DOe to provide an up-to-date capability for analyzing a variety of pre-combustion, combustion, and post-combustion options in an integrated framework. A unique capability allows performance and costs to be modeled probabilistically, which allows explicit characterization of uncertainties and risks.
瓶颈链路队列长度的网络认知模型%Network Cognitive Model of Bottleneck Link Queue Length
赵淼; 王辉
2012-01-01
为解决传统传输控制协议(TCP)在异构网络中效率较低的问题,给出网络状态认知的定义,建立以瓶颈链路队列长度为目标量的网络认知模型,采用TCP-L传输控制协议进行仿真.实验结果证明,该模型能准确估计瓶颈链路队列长度的动态变化趋势.TCP-L协议能在不同负荷的背景流条件下稳定发送窗口、往返传输时延和队列长度,减少拥塞发生,提高吞吐量和传输效率.%In view bf the traditional Transmission Control Protocol(TCP) control protocol efficiency in heterogeneous network, this paper gives the definition of the cognition of the network status, proposes and constructs a network cognitive model which makes the length of bottleneck link queue as the target parameter. This model uses TCP-L transmission control protocol to finish simulation experiments. Experimental result shows that this model can more accurately estimate the dynamic change trend of bottleneck link queue's length, and its estimate can be more accurately located in the gathering area of true values. Under different background flow conditions, the TCP-L protocol can stabilize sending window, round trip transmission delay and queue length, reduce congestion and improve throughput and transmission efficiency.
Autonomous Traffic Signal Control Model with Neural Network Analogy
Ohira, T
1997-01-01
We propose here an autonomous traffic signal control model based on analogy with neural networks. In this model, the length of cycle time period of traffic lights at each signal is autonomously adapted. We find a self-organizing collective behavior of such a model through simulation on a one-dimensional lattice model road: traffic congestion is greatly diffused when traffic signals have such autonomous adaptability with suitably tuned parameters. We also find that effectiveness of the system emerges through interactions between units and shows a threshold transition as a function of proportion of adaptive signals in the model.
Bin Du; Jiayun Zhang; Tuping Zhou; Qifeng Shu
2003-01-01
The upward bubble velocity and the pierce length distributions in a sectional water model of the copper convener in Guixi Smelter in Jiangxi, China, were measured using a two-contact electro-resistivity probe. In the case of using a single tuyere, the bubble velocity distribution along longitudinal direction was similar to that derived from Guassian function. Beyond the center of the longitudinal range, the bubble pierce length exhibited a sudden increase. The upward bubble velocity at a specified location could go up to meters per second. Its probability at a fixed location obeys a lognormal function; the bubble pierce length there varies bellow a few centimeters. In the case of using multi-tuyeres, the upward bubble velocity was roughly uniform right above the tuyeres and showed a slow decrease beyond this region. The bubble pierce length within both of these two regions was roughly uniform. Its average value in the former region, however, was found to be somewhat lower than that in the later.
LIANG Bing-chen; LI Hua-jun; LEE Dong-yong
2006-01-01
The effects of waves on Surface Drag Coefficient (SDC) and surface mixing length were analyzed and discussed by carrying out three-dimensional current modeling for the Bohai Sea in the present work. A three- dimensional coupled hydrodynamical-ecological model for regional and shelf seas (COHERENS) incorporating the influences of wave-current interactions was coupled with the third-generation wave model swan taking into account time-varying currents. The effects of waves on currents were included in the SDC, surface mixing length and bottom drag coefficient. Firstly, the formulations in Donelan were incorporated into the COHERENS to account for wave-dependent SDC. In order to compare simulation results for the wave-dependent SDC, the simulation for wind-dependent SDC was also carried out. Second, Wave-Induced Surface Mixing Length (described as WISML sometimes in this paper) was incorporated into the COHERENS. Four numerical experiments were conducted to discuss the effects of two kinds of wave processes. Generally, the values of time series of current velocity and water surface elevation given by the simulation with all of the three wave processes have a good agreement with observed data. The existence of WISML changes obviously current vertical profiles and the existence of the wave dependent SDC modifies the current field of both top and bottom layers with the wind-dependent SDC.
Ferromagnetic/superconducting bilayer structure: A model system for spin diffusion length estimation
Soltan, S; Habermeier, H U
2004-01-01
We report detailed studies on ferromagnet--superconductor bilayer structures. Epitaxial bilayer structures of half metal--colossal magnetoresistive La$_{\\mathrm{2/3}}$Ca$_{\\mathrm{1/3}}$MnO$_{\\mathrm{3}}$ (HM--CMR) and high--$T_{\\mathrm{c}}$ superconducting YBa$_{\\mathrm{2}}$Cu$_{\\mathrm{3}}$O$_{\\mathrm{7-\\delta}}$(HTSC) are grown on SrTiO$_3$ (100) single--crystalline substrates using pulsed laser deposition. Magnetization $M$(T) measurements show the coexistence of ferromagnetism and superconductivity in these structures at low temperatures. Using the HM--CMR layer as an electrode for spin polarized electrons, we discuss the role of spin polarized self injection into the HTSC layer. The experimental results are in good agreement with a presented theoretical estimation, where the spin diffusion length $\\xi_{\\mathrm {FM}}$ is found to be in the range of $\\xi_{\\mathrm{FM}} \\approx$ 10 nm.
Exponential Decay of Loop Lengths in the Loop O( n) Model with Large n
Duminil-Copin, Hugo; Peled, Ron; Samotij, Wojciech; Spinka, Yinon
2017-02-01
The loop O( n) model is a model for a random collection of non-intersecting loops on the hexagonal lattice, which is believed to be in the same universality class as the spin O( n) model. It has been conjectured that both the spin and the loop O( n) models exhibit exponential decay of correlations when n > 2. We verify this for the loop O( n) model with large parameter n, showing that long loops are exponentially unlikely to occur, uniformly in the edge weight x. Our proof provides further detail on the structure of typical configurations in this regime. Putting appropriate boundary conditions, when nx 6 is sufficiently small, the model is in a dilute, disordered phase in which each vertex is unlikely to be surrounded by any loops, whereas when nx 6 is sufficiently large, the model is in a dense, ordered phase which is a small perturbation of one of the three ground states.
Effect of length of the observed dataset on the calibration of a distributed hydrological model
Cui, X.; Sun, W.; Teng, J.; Song, H.; Yao, X.
2015-05-01
Calibration of hydrological models in ungauged basins is now a hot research topic in the field of hydrology. In addition to the traditional method of parameter regionalization, using discontinuous flow observations to calibrate hydrological models has gradually become popular in recent years. In this study, the possibility of using a limited number of river discharge data to calibrate a distributed hydrological model, the Soil and Water Assessment Tool (SWAT), was explored. The influence of the quantity of discharge measurements on model calibration in the upper Heihe Basin was analysed. Calibration using only one year of daily discharge measurements was compared with calibration using three years of discharge data. The results showed that the parameter values derived from calibration using one year's data could achieve similar model performance with calibration using three years' data, indicating that there is a possibility of using limited numbers of discharge data to calibrate the SWAT model effectively in poorly gauged basins.
An efficient model for predicting mixing lengths in serial pumping of petroleum products
Baptista, Renan Martins [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil). Centro de Pesquisas. Div. de Explotacao]. E-mail: renan@cenpes.petrobras.com.br; Rachid, Felipe Bastos de Freitas [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Engenharia Mecanica]. E-mail: rachid@mec.uff.br; Araujo, Jose Henrique Carneiro de [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Ciencia da Computacao]. E-mail: jhca@dcc.ic.uff.br
2000-07-01
This paper presents a new model for estimating mixing volumes which arises in batching transfers in multi product pipelines. The novel features of the model are the incorporation of the flow rate variation with time and the use of a more precise effective dispersion coefficient, which is considered to depend on the concentration. The governing equation of the model forms a non linear initial value problem that is solved by using a predictor corrector finite difference method. A comparison among the theoretical predictions of the proposed model, a field test and other classical procedures show that it exhibits the best estimate over the whole range of admissible concentrations investigated. (author)
Yatracos, Yannis G.
2013-01-01
The inherent bias pathology of the maximum likelihood (ML) estimation method is confirmed for models with unknown parameters $\\theta$ and $\\psi$ when MLE $\\hat \\psi$ is function of MLE $\\hat \\theta.$ To reduce $\\hat \\psi$'s bias the likelihood equation to be solved for $\\psi$ is updated using the model for the data $Y$ in it. Model updated (MU) MLE, $\\hat \\psi_{MU},$ often reduces either totally or partially $\\hat \\psi$'s bias when estimating shape parameter $\\psi.$ For the Pareto model $\\hat...
A semi-analytical model for the acoustic impedance of finite length circular holes with mean flow
Yang, Dong; Morgans, Aimee S.
2016-12-01
The acoustic response of a circular hole with mean flow passing through it is highly relevant to Helmholtz resonators, fuel injectors, perforated plates, screens, liners and many other engineering applications. A widely used analytical model [M.S. Howe. "Onthe theory of unsteady high Reynolds number flow through a circular aperture", Proc. of the Royal Soc. A. 366, 1725 (1979), 205-223] which assumes an infinitesimally short hole was recently shown to be insufficient for predicting the impedance of holes with a finite length. In the present work, an analytical model based on Green's function method is developed to take the hole length into consideration for "short" holes. The importance of capturing the modified vortex noise accurately is shown. The vortices shed at the hole inlet edge are convected to the hole outlet and further downstream to form a vortex sheet. This couples with the acoustic waves and this coupling has the potential to generate as well as absorb acoustic energy in the low frequency region. The impedance predicted by this model shows the importance of capturing the path of the shed vortex. When the vortex path is captured accurately, the impedance predictions agree well with previous experimental and CFD results, for example predicting the potential for generation of acoustic energy at higher frequencies. For "long" holes, a simplified model which combines Howe's model with plane acoustic waves within the hole is developed. It is shown that the most important effect in this case is the acoustic non-compactness of the hole.
Granato, Enzo
2012-02-01
Phase coherence and vortex order in the fully frustrated XY model on a two-dimensional honeycomb lattice are studied by extensive Monte Carlo simulations using the parallel tempering method and finite-size scaling. No evidence is found for an equilibrium order-disorder or a spin/vortex-glass transition, suggested in previous simulation works. Instead, the scaling analysis of correlations of phase and vortex variables in the full equilibrated system is consistent with a phase transition where the critical temperature vanishes and the correlation lengths diverge as a power law with decreasing temperatures and corresponding critical exponents νph and νv. This behavior and the near agreement of the critical exponents suggest a zero-temperature transition scenario where phase and vortex variables remain coupled on large length scales.
Mullett, J. D.; Dodd, R.; Williams, C. J.; Triantos, G.; Dearden, G.; Shenton, A. T.; Watkins, K. G.; Carroll, S. D.; Scarisbrick, A. D.; Keen, S.
2007-08-01
This work involves a study on laser ignition (LI) in an internal combustion (IC) engine and investigates the effects on control of engine combustion performance and stability of varying specific laser parameters (beam energy, beam quality, minimum beam waist size, focal point volume and focal length). A Q-switched Nd : YAG laser operating at the fundamental wavelength 1064 nm was successfully used to ignite homogeneous stoichiometric gasoline and air mixtures in one cylinder of a 1.6 litre IC test engine, where the remaining three cylinders used conventional electrical spark ignition (SI). A direct comparison between LI and conventional SI is presented in terms of changes in coefficient of variability in indicated mean effective pressure (COVIMEP) and the variance in the peak cylinder pressure position (VarPPP). The laser was individually operated in three different modes by changing the diameter of the cavity aperture, where the results show that for specific parameters, LI performed better than SI in terms of combustion performance and stability. Minimum ignition energies for misfire free combustion ranging from 4 to 28 mJ were obtained for various optical and laser configurations and were compared with the equivalent minimum optical breakdown energies in air.
Mathematical model of fructan biosynthesis and polymer length distribution in plants
Rasmussen, Gitte Susanne; Thornley, John H. M.; Parsons, Anthony J.;
2013-01-01
Background and Aims There are many unresolved issues concerning the biochemistry of fructan biosynthesis. The aim of this paper is to address some of these by means of modelling mathematically the biochemical processes.Methods A model has been constructed for the step-by-step synthesis of fructan...
Kranenburg, C.
1998-01-01
Adopting a 1DV numerical model including the standard k-eps turbulence model, Winterwerp et al. (1999) calculated a saturation concentration for an initially uniform distribution of fine sediment concentration in steady flow. At concentrations exceeding the saturation concentration the concentration
Possible damping model of the 6 year oscillation signal in length of day
Duan, Pengshuo; Liu, Genyou; Hu, Xiaogang; Sun, Yafei; Li, Honglei
2017-04-01
A significant 6 year oscillation signal exists in the observed length-of-day (LOD) series. We recently used normal Morlet wavelet transform method to recover this oscillation signal. The result indicates that the amplitude of this oscillation has been decreasing for the over past 50 years. Using the simulation analysis, this study further demonstrates that the above result is reliable. However, the geophysical mechanism responsible for this decrease is less clear. Here, we develop a temporal-decaying function to characterize the secular attenuation of the oscillation signal. Using the least squared method, we obtain the corresponding quality factor Q value (51.6 ± 0.4) and the damping relaxation time τ (99.2 ± 0.8 years). We find the attenuation of the 6 year oscillation signal and its Q value can be explained by previous theoretical prediction, providing constraints on the related physical parameters of the lowermost mantle. The dissipative effect of electromagnetic coupling at the core-mantle boundary is likely to be a primary factor to cause the decaying of the 6 year oscillation signal.
Application of nonlocal models to nano beams. Part II: Thickness length scale effect.
Kim, Jun-Sik
2014-10-01
Applicability of nonlocal models to nano-beams is discussed in terms of the Eringen's nonlocal Euler-Bernoulli (EB) beam model. In literature, most work has taken the axial coordinate derivative in the Laplacian operator presented in nonlocal elasticity. This causes that the non-locality always makes the beam soften as compared to the local counterpart. In this paper, the thickness scale effect is solely considered to investigate if the nonlocal model can simulate stiffening effect. Taking the thickness derivative in the Laplacian operator leads to the presence of a surface stress state. The governing equation derived is compared to that of the EB model with the surface stress. The results obtained reveal that the nonlocality tends to decrease the bending moment stiffness whereas to increase the bending rigidity in the governing equation. This tendency also depends on the surface conditions.
A Directed Continuous Time Random Walk Model with Jump Length Depending on Waiting Time
Long Shi
2014-01-01
Full Text Available In continuum one-dimensional space, a coupled directed continuous time random walk model is proposed, where the random walker jumps toward one direction and the waiting time between jumps affects the subsequent jump. In the proposed model, the Laplace-Laplace transform of the probability density function P(x,t of finding the walker at position x at time t is completely determined by the Laplace transform of the probability density function φ(t of the waiting time. In terms of the probability density function of the waiting time in the Laplace domain, the limit distribution of the random process and the corresponding evolving equations are derived.
Impact of time-domain IP pulse length on measured data and inverted models
Olsson, P. I.; Fiandaca, G.; Dahlin, T.;
2015-01-01
The duration of time domain (TD) induced polarization (IP) current injections has significant impact on the acquired IP data as well as on the inversion models, if the standard evaluation procedure is followed. However, it is still possible to retrieve similar inversion models if the waveform...... of the injected current and the IP response waveform are included in the inversion. The on-time also generally affects the signal-tonoise ratio (SNR) where an increased on-time gives higher SNR for the IP data....
Ali Zare
2011-10-01
Full Text Available Survival analysis is a set of methods used for analysis of the data which exist until the occurrence of an event. This study aimed to compare the results of the use of the semi-parametric Cox model with parametric models to determine the factors influencing the length of stay of patients in the inpatient units of Women Hospital in Tehran, Iran. In this historical cohort study all 3421 charts of the patients admitted to Obstetrics, Surgery and Oncology units in 2008 were reviewed and the required patient data such as medical insurance coverage types, admission months, days and times, inpatient units, final diagnoses, the number of diagnostic tests, admission types were collected. The patient length of stay in hospitals leading to recoverys was considered as a survival variable. To compare the semi-parametric Cox model and parametric (including exponential, Weibull, Gompertz, log-normal, log-logistic and gamma models and find the best model fitted to studied data, Akaike's Information Criterion (AIC and Cox-Snell residual were used. P<0.05 was considered as statistically significant. AIC and Cox-Snell residual graph showed that the gamma model had the lowest AIC (4288.598 and the closest graph to the bisector. The results of the gamma model showed that factors affecting the patient length of stay were admission day, inpatient unit, related physician specialty, emergent admission, final diagnosis and the number of laboratory tests, radiographies and sonographies (P<0.05. The results showed that the gamma model provided a better fit to the studied data than the Cox proportional hazards model. Therefore, it is better for researchers of healthcare field to consider this model in their researches about the patient length of stay (LOS if the assumption of proportional hazards is not fulfilled.
A New European Slope Length and Steepness Factor (LS-Factor for Modeling Soil Erosion by Water
Panos Panagos
2015-04-01
Full Text Available The Universal Soil Loss Equation (USLE model is the most frequently used model for soil erosion risk estimation. Among the six input layers, the combined slope length and slope angle (LS-factor has the greatest influence on soil loss at the European scale. The S-factor measures the effect of slope steepness, and the L-factor defines the impact of slope length. The combined LS-factor describes the effect of topography on soil erosion. The European Soil Data Centre (ESDAC developed a new pan-European high-resolution soil erosion assessment to achieve a better understanding of the spatial and temporal patterns of soil erosion in Europe. The LS-calculation was performed using the original equation proposed by Desmet and Govers (1996 and implemented using the System for Automated Geoscientific Analyses (SAGA, which incorporates a multiple flow algorithm and contributes to a precise estimation of flow accumulation. The LS-factor dataset was calculated using a high-resolution (25 m Digital Elevation Model (DEM for the whole European Union, resulting in an improved delineation of areas at risk of soil erosion as compared to lower-resolution datasets. This combined approach of using GIS software tools with high-resolution DEMs has been successfully applied in regional assessments in the past, and is now being applied for first time at the European scale.
Langbehn, D R; Brinkman, R R; Falush, D; Paulsen, J S; Hayden, M R
2004-04-01
Huntington's disease (HD) is a neurodegenerative disorder caused by an unstable CAG repeat. For patients at risk, participating in predictive testing and learning of having CAG expansion, a major unanswered question shifts from "Will I get HD?" to "When will it manifest?" Using the largest cohort of HD patients analyzed to date (2913 individuals from 40 centers worldwide), we developed a parametric survival model based on CAG repeat length to predict the probability of neurological disease onset (based on motor neurological symptoms rather than psychiatric onset) at different ages for individual patients. We provide estimated probabilities of onset associated with CAG repeats between 36 and 56 for individuals of any age with narrow confidence intervals. For example, our model predicts a 91% chance that a 40-year-old individual with 42 repeats will have onset by the age of 65, with a 95% confidence interval from 90 to 93%. This model also defines the variability in HD onset that is not attributable to CAG length and provides information concerning CAG-related penetrance rates.
Licquia, Timothy C.; Newman, Jeffrey A.
2016-11-01
The exponential scale length (L d ) of the Milky Way’s (MW’s) disk is a critical parameter for describing the global physical size of our Galaxy, important both for interpreting other Galactic measurements and helping us to understand how our Galaxy fits into extragalactic contexts. Unfortunately, current estimates span a wide range of values and are often statistically incompatible with one another. Here, we perform a Bayesian meta-analysis to determine an improved, aggregate estimate for L d , utilizing a mixture-model approach to account for the possibility that any one measurement has not properly accounted for all statistical or systematic errors. Within this machinery, we explore a variety of ways of modeling the nature of problematic measurements, and then employ a Bayesian model averaging technique to derive net posterior distributions that incorporate any model-selection uncertainty. Our meta-analysis combines 29 different (15 visible and 14 infrared) photometric measurements of L d available in the literature; these involve a broad assortment of observational data sets, MW models and assumptions, and methodologies, all tabulated herein. Analyzing the visible and infrared measurements separately yields estimates for L d of {2.71}-0.20+0.22 kpc and {2.51}-0.13+0.15 kpc, respectively, whereas considering them all combined yields 2.64 ± 0.13 kpc. The ratio between the visible and infrared scale lengths determined here is very similar to that measured in external spiral galaxies. We use these results to update the model of the Galactic disk from our previous work, constraining its stellar mass to be {4.8}-1.1+1.5× {10}10 M ⊙, and the MW’s total stellar mass to be {5.7}-1.1+1.5× {10}10 M ⊙.
Optical modeling of plasma-deposited ZnO films: Electron scattering at different length scales
Knoops, Harm C. M., E-mail: H.C.M.Knoops@tue.nl; Loo, Bas W. H. van de; Smit, Sjoerd; Ponomarev, Mikhail V.; Weber, Jan-Willem; Sharma, Kashish [Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (Netherlands); Kessels, Wilhelmus M. M.; Creatore, Mariadriana, E-mail: M.Creatore@tue.nl [Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands and Solliance, High Tech Campus 5, 5656 AE Eindhoven (Netherlands)
2015-03-15
In this work, an optical modeling study on electron scattering mechanisms in plasma-deposited ZnO layers is presented. Because various applications of ZnO films pose a limit on the electron carrier density due to its effect on the film transmittance, higher electron mobility values are generally preferred instead. Hence, insights into the electron scattering contributions affecting the carrier mobility are required. In optical models, the Drude oscillator is adopted to represent the free-electron contribution and the obtained optical mobility can be then correlated with the macroscopic material properties. However, the influence of scattering phenomena on the optical mobility depends on the considered range of photon energy. For example, the grain-boundary scattering is generally not probed by means of optical measurements and the ionized-impurity scattering contribution decreases toward higher photon energies. To understand this frequency dependence and quantify contributions from different scattering phenomena to the mobility, several case studies were analyzed in this work by means of spectroscopic ellipsometry and Fourier transform infrared (IR) spectroscopy. The obtained electrical parameters were compared to the results inferred by Hall measurements. For intrinsic ZnO (i-ZnO), the in-grain mobility was obtained by fitting reflection data with a normal Drude model in the IR range. For Al-doped ZnO (Al:ZnO), besides a normal Drude fit in the IR range, an Extended Drude fit in the UV-vis range could be used to obtain the in-grain mobility. Scattering mechanisms for a thickness series of Al:ZnO films were discerned using the more intuitive parameter “scattering frequency” instead of the parameter “mobility”. The interaction distance concept was introduced to give a physical interpretation to the frequency dependence of the scattering frequency. This physical interpretation furthermore allows the prediction of which Drude models can be used in a specific
A combined computational and structural model of the full-length human prolactin receptor
Bugge, Katrine Østergaard; Papaleo, Elena; Haxholm, Gitte Wolfsberg
2016-01-01
-angle X-ray scattering, native mass spectrometry and NMR spectroscopy. Along with previously published data, these are integrated by molecular modelling to generate a full receptor structure. The result provides the first full view of a class I cytokine receptor, exemplifying the architecture of more than...... 40 different receptor chains, and reveals that the extracellular domain is merely the tip of a molecular iceberg....
赵瑞曼; 潘冠华; 方建勇
2014-01-01
The classical software reliability model of Cheung based on architecture analysis is imperfect when applied to soft-ware which has non-uniqueness terminal node because of ideal assumptions. In order to handle this problem, an improved model is established through two improvement as follows:first, probability matrix of control transfer from start node to other inner nodes in a given software is computed independently of control transfer within inner nodes on the assumptions that the start node is inaccessible to control transfer from any inner nodes;and then, probability matrixes of control transfer within in-ner nodes are reconfigured by weaken the difference between inner nodes and ending nodes. In order to measure the reliability of software with VLMC control transfer flow, the variable length Markov control sequence chain is converted to simple Markov chain by node expansion and conditional transfer probability redistribution. By using deductive inference, a formal proof for the new model is given in this essay. In the end, effectiveness and simplicity of the proposed method is verified by a software example.%针对现有软件可靠性模型普遍不适用于实际软件的问题，分析了软件内部模块间控制转移机理，通过分离入口模块，提取一阶控制转移概率矩阵；弱化内部模块与出口模块间差异，重构二阶以上转移概率矩阵，在改进Cheung模型的基础上建立一个更符合软件实际的可靠性度量模型。针对变阶依赖（ VLMC）控制转移导致的可靠性度量难问题，通过对导致复杂依赖的多入多出模块进行节点扩展，将VLMC控制流转化为Markov链，利用所建立的软件可靠性模型对VLMC控制流软件进行可靠性度量。研究利用演绎推理对所建立模型进行了正确性形式化证明。最后给出了方法的实例验证。
Path modeling and process control
Høskuldsson, Agnar; Rodionova, O.; Pomerantsev, A.
2007-01-01
and having three or more stages. The methods are applied to a process control of a multi-stage production process having 25 variables and one output variable. When moving along the process, variables change their roles. It is shown how the methods of path modeling can be applied to estimate variables...... of the next stage with the purpose of obtaining optimal or almost optimal quality of the output variable. An important aspect of the methods presented is the possibility of extensive graphic analysis of data that can provide the engineer with a detailed view of the multi-variate variation in data.......Many production processes are carried out in stages. At the end of each stage, the production engineer can analyze the intermediate results and correct process parameters (variables) of the next stage. Both analysis of the process and correction to process parameters at next stage should...
Doughty, Alice M.; Mackintosh, Andrew N.; Anderson, Brian M.; Dadic, Ruzica; Putnam, Aaron E.; Barrell, David J. A.; Denton, George H.; Chinn, Trevor J. H.; Schaefer, Joerg M.
2017-07-01
Recent model studies suggest that interannual climatic variability could be confounding the interpretation of glacier fluctuations as climate signals. Paleoclimate interpretations of moraine positions and associated cosmogenic exposure ages may have large uncertainties if the glacier in question was sensitive to interannual variability. Here we address the potential for interannual temperature and precipitation variability to cause large shifts in glacier length during the Holocene. Using a coupled ice-flow and mass-balance model, we simulate the response of Cameron Glacier, a small mountain glacier in New Zealand's Southern Alps, to two types of climate forcing: equilibrium climate and variable climate. Our equilibrium results suggest a net warming trend from the Early Holocene (10.69 ± 0.41 ka; 2.7 °C cooler than present) to the Late Holocene (CE 1864; 1.3 °C cooler than present). Interannual climatic variability cannot account for the Holocene glacier fluctuations in this valley. Future studies should consider local environmental characteristics, such as a glacier's climatic setting and topography, to determine the magnitude of glacier length changes caused by interannual variability.
A combined computational and structural model of the full-length human prolactin receptor
Bugge, Katrine Østergaard; Papaleo, Elena; Haxholm, Gitte Wolfsberg;
2016-01-01
The prolactin receptor is an archetype member of the class I cytokine receptor family, comprising receptors with fundamental functions in biology as well as key drug targets. Structurally, each of these receptors represent an intriguing diversity, providing an exceptionally challenging target...... for structural biology. Here, we access the molecular architecture of the monomeric human prolactin receptor by combining experimental and computational efforts. We solve the NMR structure of its transmembrane domain in micelles and collect structural data on overlapping fragments of the receptor with small......-angle X-ray scattering, native mass spectrometry and NMR spectroscopy. Along with previously published data, these are integrated by molecular modelling to generate a full receptor structure. The result provides the first full view of a class I cytokine receptor, exemplifying the architecture of more than...
A combined computational and structural model of the full-length human prolactin receptor
Bugge, Katrine; Papaleo, Elena; Haxholm, Gitte W.; Hopper, Jonathan T. S.; Robinson, Carol V.; Olsen, Johan G.; Lindorff-Larsen, Kresten; Kragelund, Birthe B.
2016-05-01
The prolactin receptor is an archetype member of the class I cytokine receptor family, comprising receptors with fundamental functions in biology as well as key drug targets. Structurally, each of these receptors represent an intriguing diversity, providing an exceptionally challenging target for structural biology. Here, we access the molecular architecture of the monomeric human prolactin receptor by combining experimental and computational efforts. We solve the NMR structure of its transmembrane domain in micelles and collect structural data on overlapping fragments of the receptor with small-angle X-ray scattering, native mass spectrometry and NMR spectroscopy. Along with previously published data, these are integrated by molecular modelling to generate a full receptor structure. The result provides the first full view of a class I cytokine receptor, exemplifying the architecture of more than 40 different receptor chains, and reveals that the extracellular domain is merely the tip of a molecular iceberg.
Modeling the effect of probe force on length measurements on polymer parts
Mohammadi, Ali; Sonne, Mads Rostgaard; Dalla Costa, Giuseppe
2016-01-01
Measurement uncertainty at micrometer level is in the future going to be very common in dimensional measurements on polymer parts. Accurate dimensional measurement of polymer parts is becoming a key and common practice in the industry, especially when micrometer tolerances are required. When...... conducting measurements with a contact probe there is always a force applied to the part. This force (0.3N – 3.3N) leads to deformations that an influence the final result. The unknown deformation of the part under the measurement conditions can produce significant errors in the measurement. In the present...... work, Hertzian contact theory was applied to find the deformation analytically, where the measuring force was imposed to the part. Material properties of the polymer and radius of the probe tip were known parameters. The finite element software ABAQUS was then used to model the contact problem...
Modelling solar cycle length based on Poincaré maps for Lorenz-type equations
H. Lundstedt
2010-04-01
Full Text Available Two systems of Lorenz-type equations modelling solar magnetic activity are studied: Firstly a low order dynamic system in which the toroidal and poloidal fields are represented by x- and y-coordinates respectively, and the hydrodynamical information is given by the z coordinate. Secondly a complex generalization of the three ordinary differential equations studied by Lorenz. By studying the Poincaré map we give numerical evidence that the flow has an attractor with fractal structure. The period is defined as the time needed for a point on a hyperplane to return to the hyperplane again. The periods are distributed in an interval. For large values of the Dynamo number there is a long tail toward long periods and other interesting comet-like features. These general relations found for periods can further be physically interpreted with improved helioseismic estimates of the parameters used by the dynamical systems. Solar Dynamic Observatory is expected to offer such improved measurements.
Ahmadi, Seyed Hamid; Sepaskhah, A R; Andersen, Mathias Neumann
2014-01-01
Root length density (RLD) is a highly wanted parameter for use in crop growth modeling but difficult to measure under field conditions. Therefore, artificial neural networks (ANNs) were implemented to predict the RLD of field grown potatoes that were subject to three irrigation strategies and three......) of the eight input variables: soil layer intervals (D), percentages of sand (Sa), silt (Si), and clay (Cl), bulk density of soil layers (Bd), weighted soil moisture deficit during the irrigation strategies period (SMD), geometric mean particle size diameter (dg), and geometric standard deviation (σg...... under a range of soil physical conditions with a high degree of accuracy and may be used in crop growth modeling....
A MODEL AND CONTROLLER REDUCTION METHOD FOR ROBUST CONTROL DESIGN.
YUE,M.; SCHLUETER,R.
2003-10-20
A bifurcation subsystem based model and controller reduction approach is presented. Using this approach a robust {micro}-synthesis SVC control is designed for interarea oscillation and voltage control based on a small reduced order bifurcation subsystem model of the full system. The control synthesis problem is posed by structured uncertainty modeling and control configuration formulation using the bifurcation subsystem knowledge of the nature of the interarea oscillation caused by a specific uncertainty parameter. Bifurcation subsystem method plays a key role in this paper because it provides (1) a bifurcation parameter for uncertainty modeling; (2) a criterion to reduce the order of the resulting MSVC control; and (3) a low order model for a bifurcation subsystem based SVC (BMSVC) design. The use of the model of the bifurcation subsystem to produce a low order controller simplifies the control design and reduces the computation efforts so significantly that the robust {micro}-synthesis control can be applied to large system where the computation makes robust control design impractical. The RGA analysis and time simulation show that the reduced BMSVC control design captures the center manifold dynamics and uncertainty structure of the full system model and is capable of stabilizing the full system and achieving satisfactory control performance.
Multiplicity Control in Structural Equation Modeling
Cribbie, Robert A.
2007-01-01
Researchers conducting structural equation modeling analyses rarely, if ever, control for the inflated probability of Type I errors when evaluating the statistical significance of multiple parameters in a model. In this study, the Type I error control, power and true model rates of famsilywise and false discovery rate controlling procedures were…
g4c2c: A Model for Citizen Engagement at Arms’ Length from Government
Axel Bruns
2011-03-01
Full Text Available Normal 0 false false false EN-AU X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The recognition that Web 2.0 applications and social media sites will strengthen and improve interaction between governments and citizens has resulted in a global push into new e-democracy or Government 2.0 spaces. These typically follow government-to-citizen (g2c or citizen-to-citizen (c2c models, but both these approaches are problematic: g2c is often concerned more with service delivery to citizens as clients, or exists to make a show of ‘listening to the public’ rather than to genuinely source citizen ideas for government policy, while c2c often takes place without direct government participation and therefore cannot ensure that the outcomes of citizen deliberations are accepted into the government policy-making process. Building on recent examples of Australian Government 2.0 initiatives, we suggest a new approach based on government support for citizen-to-citizen engagement, or g4c2c, as a workable compromise, and suggest that public service broadcasters should play a key role in facilitating this model of citizen engagement.
Adams, E. W.; Johnston, J. P.
1983-01-01
A mixing-length model is developed for the prediction of turbulent boundary layers with convex streamwise curvature. For large layer thickness ratio, delta/R greater than 0.05, the model scales mixing length on the wall radius of curvature, R. For small delta/R, ordinary flat wall modeling is used for the mixing-length profile with curvature corrections, following the recommendations of Eide and Johnston (1976). Effects of streamwise change of curvature are considered; a strong lag from equilibrium is required when R increases downstream. Fifteen separate data sets were compared, including both hydrodynamic and heat transfer results. Six of these computations are presented and compared to experiment.
Dhasarathy, Deepak
2010-01-01
The vertical load on a moving tire was estimated by using accelerometers attached to the inner liner of a tire. The acceleration signal was processed to obtain the contact patch length created by the tire on the road surface. Then an appropriate equation relating the patch length to the vertical load is used to calculate the load. In order to obtain the needed data, tests were performed on a flat-track test machine at the Goodyear Innovation Center in Akron, Ohio; tests were also conducted on...
Rrp6p controls mRNA poly(a) tail length and its decoration with poly(a) binding proteins
Schmid, Manfred; Poulsen, Mathias Bach; Olszewski, Pawel;
2012-01-01
Poly(A) (pA) tail binding proteins (PABPs) control mRNA polyadenylation, stability, and translation. In a purified system, S. cerevisiae PABPs, Pab1p and Nab2p, are individually sufficient to provide normal pA tail length. However, it is unknown how this occurs in more complex environments. Here ...
Flagg, Thomas P; Cazorla, Olivier; Remedi, Maria S; Haim, Todd E; Tones, Michael A; Bahinski, Anthony; Numann, Randal E; Kovacs, Attila; Schaffer, Jean E; Nichols, Colin G; Nerbonne, Jeanne M
2009-01-02
Previous studies demonstrated increased fatty acid uptake and metabolism in MHC-FATP transgenic mice that overexpress fatty acid transport protein (FATP)1 in the heart under the control of the alpha-myosin heavy chain (alpha-MHC) promoter. Doppler tissue imaging and hemodynamic measurements revealed diastolic dysfunction, in the absence of changes in systolic function. The experiments here directly test the hypothesis that the diastolic dysfunction in MHC-FATP mice reflects impaired ventricular myocyte contractile function. In vitro imaging of isolated adult MHC-FATP ventricular myocytes revealed that mean diastolic sarcomere length is significantly (P<0.01) shorter than in wild-type (WT) cells (1.79+/-0.01 versus 1.84+/-0.01 microm). In addition, the relaxation rate (dL/dt) is significantly (P<0.05) slower in MHC-FATP than WT myocytes (1.58+/-0.09 versus 1.92+/-0.13 microm/s), whereas both fractional shortening and contraction rates are not different. Application of 40 mmol/L 2,3-butadionemonoxime (a nonspecific ATPase inhibitor that relaxes actin-myosin interactions) increased diastolic sarcomere length in both WT and MHC-FATP myocytes to the same length, suggesting that MHC-FATP myocytes are partially activated at rest. Direct measurements of intracellular Ca(2+) revealed that diastolic [Ca(2+)](i) is unchanged in MHC-FATP myocytes and the rate of calcium removal is unexpectedly faster in MHC-FATP than WT myocytes. Moreover, diastolic sarcomere length in MHC-FATP and WT myocytes was unaffected by removal of extracellular Ca(2+) or by buffering of intracellular Ca(2+) with the Ca(2+) chelator BAPTA (100 micromol/L), indicating that elevated intracellular Ca(2+) does not underlie impaired diastolic function in MHC-FATP ventricular myocytes. Functional assessment of skinned myocytes, however, revealed that myofilament Ca(2+) sensitivity is markedly increased in MHC-FATP, compared with WT, ventricular cells. In addition, biochemical experiments demonstrated
A pinned polymer model of posture control
Chow, C C; Chow, Carson C; Collins, J J
1995-01-01
A phenomenological model of human posture control is posited. The dynamics are modelled as an elastically pinned polymer under the influence of noise. The model accurately reproduces the two-point correlation functions of experimental posture data and makes predictions for the response function of the postural control system. The physiological and clinical significance of the model is discussed.
CONTROL SYSTEM IDENTIFICATION THROUGH MODEL MODULATION METHODS
identification has been achieved by using model modulation techniques to drive dynamic models into correspondence with operating control systems. The system ... identification then proceeded from examination of the model and the adaptive loop. The model modulation techniques applied to adaptive control
Modeling and robust control of wind turbine
Gilev, Bogdan
2016-12-01
In this paper a model of a wind turbine is evaluated, consisting of: wind speed model, mechanical and electrical model of generator and tower oscillation model. This model is linearized around of a nominal point. By using the linear model with uncertainties is synthesized a uncertain model. By using the uncertain model and robust control theory is developed a robust controller, which provide mode of stabilizing the rotor frequency and damping the tower oscillations. Finally is simulated work of nonlinear system and robust controller
Model predictive control for a thermostatic controlled system
Shafiei, Seyed Ehsan; Rasmussen, Henrik; Stoustrup, Jakob
2013-01-01
This paper proposes a model predictive control scheme to provide temperature set-points to thermostatic controlled cooling units in refrigeration systems. The control problem is formulated as a convex programming problem to minimize the overall operating cost of the system. The foodstuff temperat......This paper proposes a model predictive control scheme to provide temperature set-points to thermostatic controlled cooling units in refrigeration systems. The control problem is formulated as a convex programming problem to minimize the overall operating cost of the system. The foodstuff...
Research on cubic polynomial acceleration and deceleration control model for high speed NC machining
Hong-bin LENG; Yi-jie WU; Xiao-hong PAN
2008-01-01
To satisfy the need of high speed NC (numerical control) machining, an acceleration and deceleration (aec/dec) control model is proposed, and the speed curve is also constructed by the cubic polynomial. The proposed control model provides continuity of acceleration, which avoids the intense vibration in high speed NC machining. Based on the discrete characteristic of the data sampling interpolation, the acc/dec control discrete mathematical model is also set up and the discrete expression of the theoretical deceleration length is obtained furthermore. Aiming at the question of hardly predetermining the deceleration point in acc/dec control before interpolation, the adaptive acc/dec control algorithm is deduced from the expressions of the theoretical deceleration length. The experimental result proves that the acc/dec control model has the characteristic of easy implementation, stable movement and low impact. The model has been applied in multi-axes high speed micro fabrication machining successfully.
Context Modeling Based on Description Length%基于描述长度的Context建模算法
陈建华; 王勇; 张鸿
2016-01-01
在基于Context建模的熵编码系统中,为了达到预期的压缩性能,需要通过Context量化来缓解由高阶Context模型所引入的"Context稀释"问题.为此,该文提出一种通过最小化描述长度来实现Context量化(Minimum Description Length Context Quantization,MDLCQ)的算法.该算法使用描述长度作为评价准则,通过动态规划算法来实现单条件的最优Context量化,然后通过循环迭代来实现多条件的Context量化.该算法不仅可以得到多值信源的优化Context量化器,而且可以自适应地确定各个条件的重要性从而确定模型的最佳阶数.实验结果表明:由MDLCQ算法所得到的Context量化器,可以明显改善熵编码系统的压缩性能.%In entropy coding systems based on the context modeling, the "context dilution" problem introduced by high-order context models needs to be alleviated by the context quantization to achieve the desired compression gain.Therefore, an algorithm is proposed to implement the Context Quantization by the Minimizing Description Length (MDLCQ) in this paper. With the description length as the evaluation criterion, the Context Quantization Of Single-Condition (CQOSC) is attained by the dynamic programming algorithm. Then the context quantizer of multi-conditions can be designed by the iterated application of CQOSC. This algorithm can not only design the optimized context quantizer for multi-valued sources, but also determine adaptively the importance of every condition so as to design the best order of the model. The experimental results show that the context quantizer designed by the MDLCQ algorithm can apparently improve the compression performance of the entropy coding system.
Stochastic models, estimation, and control
Maybeck, Peter S
1982-01-01
This volume builds upon the foundations set in Volumes 1 and 2. Chapter 13 introduces the basic concepts of stochastic control and dynamic programming as the fundamental means of synthesizing optimal stochastic control laws.
Derivation of Simplified Models of Plan View Pattern Control Function for Plate Mill
JIAO Zhi-jie; HU Xian-lei; ZHAO Zhong; LIU Xiang-hua; WANG Guo-dong
2007-01-01
The plan view pattern control theoretical models were simplified. Under the condition of constant volume for the plan view pattern compensation, the relation between the thickness and the length can be simplified to the linearity in the segment for the plan view pattern control function. The compensation volume can be dispersed for easy calculation. By comparing the model calculation result with the actual result, it was concluded that the simplified model can be used for the online control process.
Garrido, Nephtali
2012-01-01
We put to the test an effective three-dimensional electrostatic potential, obtained effectively by considering an electrostatic source inside a (5+$p$)-dimensional braneworld scenario with $p$ compact and one infinite spacial extra dimensions in the RS II-$p$ model, for $p=1$ and $p=2$. This potential is regular at the source and matches the standard Coulomb potential outside a neighborhood. We use variational and perturbative approximation methods to calculate corrections to the ground energy of the Helium atom modified by this potential, by making use of a 6 and 39-parameter trial wave function of Hylleraas type for the ground state. These corrections to the ground-state energy are compared with experimental data for Helium atom in order to set bounds for the extra dimensions length scale. We find that these bounds are less restrictive than the ones obtained by Morales et. al. through a calculation using the Lamb shift in Hydrogen.
Muñoz-Jaramillo, Andrés; Martens, Petrus C H
2010-01-01
The turbulent magnetic diffusivity in the solar convection zone is one of the most poorly constrained ingredients of mean-field dynamo models. This lack of constraint has previously led to controversy regarding the most appropriate set of parameters, as different assumptions on the value of turbulent diffusivity lead to radically different solar cycle predictions. Typically, the dynamo community uses double step diffusivity profiles characterized by low values of diffusivity in the bulk of the convection zone. However, these low diffusivity values are not consistent with theoretical estimates based on mixing-length theory -- which suggest much higher values for turbulent diffusivity. To make matters worse, kinematic dynamo simulations cannot yield sustainable magnetic cycles using these theoretical estimates. In this work we show that magnetic cycles become viable if we combine the theoretically estimated diffusivity profile with magnetic quenching of the diffusivity. Furthermore, we find that the main featur...
Urriza I
2010-01-01
Full Text Available Abstract This paper presents a word length selection method for the implementation of digital controllers in both fixed-point and floating-point hardware on FPGAs. This method uses the new types defined in the VHDL-2008 fixed-point and floating-point packages. These packages allow customizing the word length of fixed and floating point representations and shorten the design cycle simplifying the design of arithmetic operations. The method performs bit-true simulations in order to determine the word length to represent the constant coefficients and the internal signals of the digital controller while maintaining the control system specifications. A mixed-signal simulation tool is used to simulate the closed loop system as a whole in order to analyze the impact of the quantization effects and loop delays on the control system performance. The method is applied to implement a digital controller for a switching power converter. The digital circuit is implemented on an FPGA, and the simulations are experimentally verified.
Hansen, Heinz Johs. Max; Carey, E.M.; Dils, R.
1970-01-01
- 1. Gas-liquid and paper chromatography have been used to determine the chain-lengths of fatty acids synthesised by purified rat liver fatty acid synthetase from [1-14C]acetyl-CoA, [1,3-14C2]malonyl-CoA and from [1-14C]acetyl-CoA plus partially purified rat liver acetyl-CoA carboxylase. - 2. A w...
Modelling and Control of a Mobile Robot
Christensen, Georg Kronborg
1998-01-01
In order to control a mobile robot, kinematic odels as well as dynamic models are required. This parer describes these basic models for an experimental mobile robot under construction at the Department of Control and Engineering Design. A description of a set of trajectory control rules is given...
Basic Research on Adaptive Model Algorithmic Control
1985-12-01
Control Conference. Richalet, J., A. Rault, J.L. Testud and J. Papon (1978). Model predictive heuristic control: applications to industrial...pp.977-982. Richalet, J., A. Rault, J. L. Testud and J. Papon (1978). Model predictive heuristic control: applications to industrial processes
Modeling and position control of tethered octocopters
de Castro Davi Ferreira
2016-01-01
Full Text Available This work presents the modeling and control of a multirotor aerial vehicle with tethered configuration. It is considered an octocopter with a saturated proportional-plus-derivative position control. A viscoelastic model is considered for the tether, which has a tension control. Numerical simulations are carried out to compare the performance of the tethred configuration with the vehicle in free flight.
Managing Delegation in Access Control Models
Ghorbel-Talbi, Meriam Ben; Cuppens-Boulahia, Nora; Bouhoula, Adel; 10.1109/ADCOM.2007.105
2010-01-01
In the field of access control, delegation is an important aspect that is considered as a part of the administration mechanism. Thus, a complete access control must provide a flexible administration model to manage delegation. Unfortunately, to our best knowledge, there is no complete model for describing all delegation requirements for role-based access control. Therefore, proposed models are often extended to consider new delegation characteristics, which is a complex task to manage and necessitate the redefinition of these models. In this paper we describe a new delegation approach for extended role-based access control models. We show that our approach is flexible and is sufficient to manage all delegation requirements.
Gesner Pereira Lopes
2013-12-01
Full Text Available Introduction In this study, we investigated radiological changes in the sigmoid colon in chagasic patients by comparing their colon lengths and caliber with those of non-chagasic living in the same region and non-chagasic living at high altitudes. Methods A total of 317 individuals were evaluated using clinical, serological and radiological methods and divided into three groups: 1 one hundred and nine non-chagasic individuals from Uberaba, Brazil; 2 sixty-one non-chagasic from Puno, Peru; 3 one hundred forty-seven chagasics examined in Uberaba, being 62 without megacolon (3A, 72 with megacolon (3B and 13 with doubtful diagnosis of megacolon (3C. Results In group 2, the sigmoid colon had a significantly larger caliber (p=0.001 and the rectosigmoid colon was longer (p<0.001 than group 1. In subgroup 3A, the sigmoid colon (p<0.001 and rectum (p<0.001 had a significantly larger caliber and the rectosigmoid was longer (p<0.001 than that of the non-chagasic individuals. In subgroup 3B, the rectosigmoid was longer in all patients, and the caliber of the sigmoid was significantly larger than that of subjects in subgroups 3A and 3C (p<0.001. Conclusions Morphometric analysis confirms that Chagas disease may increase the caliber and length of the rectosigmoid. Our results suggest that altitude, ethnicity and diet may have influenced the size and length of the rectosigmoid of andean patients.
盛强
2011-01-01
Aiming at the weak points of traditional steel pipe's fixed-length cutting control method on flying-saw machine,a control strategy based on the fuzzy self-adaptive PID method was proposed. The inputs required by the control model are fixed-length cutting error and the error change rate,and the model gives the correct additional setpoint for the three parameters of PID control individually. Thus the on-line automatic adjustment of the PID parameters was achieved. The fuzzy self-adaptive PID control was compared with traditional PID by simulation through Matlab. The results indicate that the steel pipe's fixed-length cutting dynamic control performs much better by using the fuzzy self-adaptive PID control strategy.%针对钢管定尺飞锯传统定长切割控制策略存在的问题,提出了采用模糊自适应PID的控制策略.控制器输入取钢管的定长切割偏差e和偏差变化率ec,输出取PID控制器3个参数的修正量,从而实现了PID参数的在线自整定.采用Matlab语言,进行了常规PID控制与模糊自适应PID控制动态性能的仿真比较.研究结果表明,采用模糊自适应PID控制可明显提高定尺飞锯定长切割控制系统的动态性能.
Modelling onchocerciasis transmission and control
A.P. Plaisier (Anton)
1996-01-01
textabstractIn 1990 the World Health Organization (WHO) coordinated Onchocerciasis Control Programme in West Africa (OCP) used this slogan for evaluating fifteen years of control of the parasitic disease onchocerciasis and for expressing its optimism about the future. Based on the obvious success of
Mouse gestation length is genetically determined.
Stephen A Murray
Full Text Available BACKGROUND: Preterm birth is an enormous public health problem, affecting over 12% of live births and costing over $26 billion in the United States alone. The causes are complex, but twin studies support the role of genetics in determining gestation length. Despite widespread use of the mouse in studies of the genetics of preterm birth, there have been few studies that actually address the precise natural gestation length of the mouse, and to what degree the timing of labor and birth is genetically determined. METHODOLOGY/PRINCIPAL FINDINGS: To further develop the mouse as a genetic model of preterm birth, we developed a high-throughput monitoring system and measured the gestation length in 15 inbred strains. Our results show an unexpectedly wide variation in overall gestation length between strains that approaches two full days, while intra-strain variation is quite low. Although litter size shows a strong inverse correlation with gestation length, genetic difference alone accounts for a significant portion of the variation. In addition, ovarian transplant experiments support a primary role of maternal genetics in the determination of gestation length. Preliminary analysis of gestation length in the C57BL/6J-Chr#(A/J/NaJ chromosome substitution strain (B.A CSS panel suggests complex genetic control of gestation length. CONCLUSIONS/SIGNIFICANCE: Together, these data support the role of genetics in regulating gestation length and present the mouse as an important tool for the discovery of genes governing preterm birth.
Modeling Control Situations in Power System Operations
Saleem, Arshad; Lind, Morten; Singh, Sri Niwas
2010-01-01
Increased interconnection and loading of the power system along with deregulation has brought new challenges for electric power system operation, control and automation. Traditional power system models used in intelligent operation and control are highly dependent on the task purpose. Thus, a model...... for intelligent operation and control must represent system features, so that information from measurements can be related to possible system states and to control actions. These general modeling requirements are well understood, but it is, in general, difficult to translate them into a model because of the lack...... of explicit principles for model construction. This paper presents a work on using explicit means-ends model based reasoning about complex control situations which results in maintaining consistent perspectives and selecting appropriate control action for goal driven agents. An example of power system...
Modeling Control Situations in Power System Operations
Saleem, Arshad; Lind, Morten; Singh, Sri Niwas
2010-01-01
Increased interconnection and loading of the power system along with deregulation has brought new challenges for electric power system operation, control and automation. Traditional power system models used in intelligent operation and control are highly dependent on the task purpose. Thus, a model...... for intelligent operation and control must represent system features, so that information from measurements can be related to possible system states and to control actions. These general modeling requirements are well understood, but it is, in general, difficult to translate them into a model because of the lack...... of explicit principles for model construction. This paper presents a work on using explicit means-ends model based reasoning about complex control situations which results in maintaining consistent perspectives and selecting appropriate control action for goal driven agents. An example of power system...
Seki Motoaki
2008-11-01
Full Text Available Abstract Background Thellungiella halophila (also known as Thellungiella salsuginea is a model halophyte with a small plant size, short life cycle, and small genome. It easily undergoes genetic transformation by the floral dipping method used with its close relative, Arabidopsis thaliana. Thellungiella genes exhibit high sequence identity (approximately 90% at the cDNA level with Arabidopsis genes. Furthermore, Thellungiella not only shows tolerance to extreme salinity stress, but also to chilling, freezing, and ozone stress, supporting the use of Thellungiella as a good genomic resource in studies of abiotic stress tolerance. Results We constructed a full-length enriched Thellungiella (Shan Dong ecotype cDNA library from various tissues and whole plants subjected to environmental stresses, including high salinity, chilling, freezing, and abscisic acid treatment. We randomly selected about 20 000 clones and sequenced them from both ends to obtain a total of 35 171 sequences. CAP3 software was used to assemble the sequences and cluster them into 9569 nonredundant cDNA groups. We named these cDNAs "RTFL" (RIKEN Thellungiella Full-Length cDNAs. Information on functional domains and Gene Ontology (GO terms for the RTFL cDNAs were obtained using InterPro. The 8289 genes assigned to InterPro IDs were classified according to the GO terms using Plant GO Slim. Categorical comparison between the whole Arabidopsis genome and Thellungiella genes showing low identity to Arabidopsis genes revealed that the population of Thellungiella transport genes is approximately 1.5 times the size of the corresponding Arabidopsis genes. This suggests that these genes regulate a unique ion transportation system in Thellungiella. Conclusion As the number of Thellungiella halophila (Thellungiella salsuginea expressed sequence tags (ESTs was 9388 in July 2008, the number of ESTs has increased to approximately four times the original value as a result of this effort. Our
Modeling and control of greenhouse crop growth
Rodríguez, Francisco; Guzmán, José Luis; Ramírez-Arias, Armando
2015-01-01
A discussion of challenges related to the modeling and control of greenhouse crop growth, this book presents state-of-the-art answers to those challenges. The authors model the subsystems involved in successful greenhouse control using different techniques and show how the models obtained can be exploited for simulation or control design; they suggest ideas for the development of physical and/or black-box models for this purpose. Strategies for the control of climate- and irrigation-related variables are brought forward. The uses of PID control and feedforward compensators, both widely used in commercial tools, are summarized. The benefits of advanced control techniques—event-based, robust, and predictive control, for example—are used to improve on the performance of those basic methods. A hierarchical control architecture is developed governed by a high-level multiobjective optimization approach rather than traditional constrained optimization and artificial intelligence techniques. Reference trajector...
Optimal Control Design with Limited Model Information
Farokhi, F; Johansson, K H
2011-01-01
We introduce the family of limited model information control design methods, which construct controllers by accessing the plant's model in a constrained way, according to a given design graph. We investigate the achievable closed-loop performance of discrete-time linear time-invariant plants under a separable quadratic cost performance measure with structured static state-feedback controllers. We find the optimal control design strategy (in terms of the competitive ratio and domination metrics) when the control designer has access to the local model information and the global interconnection structure of the plant-to-be-controlled. At last, we study the trade-off between the amount of model information exploited by a control design method and the best closed-loop performance (in terms of the competitive ratio) of controllers it can produce.
Tsou, Wei-Ling; Qiblawi, Sultan H.; Hosking, Ryan R.; Gomez, Christopher M.
2016-01-01
ABSTRACT Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that results from abnormal expansion of a polyglutamine (polyQ) repeat. SCA6 is caused by CAG triplet repeat expansion in the gene CACNA1A, resulting in a polyQ tract of 19-33 in patients. CACNA1A, a bicistronic gene, encodes the α1A calcium channel subunit and the transcription factor, α1ACT. PolyQ expansion in α1ACT causes degeneration in mice. We recently described the first Drosophila models of SCA6 that express α1ACT with a normal (11Q) or hyper-expanded (70Q) polyQ. Here, we report additional α1ACT transgenic flies, which express full-length α1ACT with a 33Q repeat. We show that α1ACT33Q is toxic in Drosophila, but less so than the 70Q version. When expressed everywhere, α1ACT33Q-expressing adults die earlier than flies expressing the normal allele. α1ACT33Q causes retinal degeneration and leads to aggregated species in an age-dependent manner, but at a slower pace than the 70Q counterpart. According to western blots, α1ACT33Q localizes less readily in the nucleus than α1ACT70Q, providing clues into the importance of polyQ tract length on α1ACT localization and its site of toxicity. We expect that these new lines will be highly valuable for future work on SCA6. PMID:27979829
Nonlinear control of the Salnikov model reaction
Recke, Bodil; Jørgensen, Sten Bay
1999-01-01
This paper explores different nonlinear control schemes, applied to a simple model reaction. The model is the Salnikov model, consisting of two ordinary differential equations. The control strategies investigated are I/O-linearisation, Exact linearisation, exact linearisation combined with LQR...... and Control Lyapunov Functions (CLF's). The results show that based on the lowest possible cost function and shortest settling time, the exact linearisation performs marginally better than the other methods....
Fractional Order Models of Industrial Pneumatic Controllers
Abolhassan Razminia
2014-01-01
Full Text Available This paper addresses a new approach for modeling of versatile controllers in industrial automation and process control systems such as pneumatic controllers. Some fractional order dynamical models are developed for pressure and pneumatic systems with bellows-nozzle-flapper configuration. In the light of fractional calculus, a fractional order derivative-derivative (FrDD controller and integral-derivative (FrID are remodeled. Numerical simulations illustrate the application of the obtained theoretical results in simple examples.
Xu, Jinglei; Li, Meng; Zhang, Yang; Chen, Longfei
2016-12-01
The von Karman length scale is able to reflect the size of the local turbulence structure. However, it is not suitable for the near wall region of wall-bounded flows, for its value is almost infinite there. In the present study, a simple and novel length scale combining the wall distance and the von Karman length scale is proposed by introducing a structural function. The new length scale becomes the von Karman length scale once local unsteady structures are detected. The proposed method is adopted in a series of turbulent channel flows at different Reynolds numbers. The results show that the proposed length scale with the structural function can precisely simulate turbulence at high Reynolds numbers, even with a coarse grid resolution.
Application of Model Predictive Control to BESS for Microgrid Control
Thai-Thanh Nguyen
2015-08-01
Full Text Available Battery energy storage systems (BESSs have been widely used for microgrid control. Generally, BESS control systems are based on proportional-integral (PI control techniques with the outer and inner control loops based on PI regulators. Recently, model predictive control (MPC has attracted attention for application to future energy processing and control systems because it can easily deal with multivariable cases, system constraints, and nonlinearities. This study considers the application of MPC-based BESSs to microgrid control. Two types of MPC are presented in this study: MPC based on predictive power control (PPC and MPC based on PI control in the outer and predictive current control (PCC in the inner control loops. In particular, the effective application of MPC for microgrids with multiple BESSs should be considered because of the differences in their control performance. In this study, microgrids with two BESSs based on two MPC techniques are considered as an example. The control performance of the MPC used for the control microgrid is compared to that of the PI control. The proposed control strategy is investigated through simulations using MATLAB/Simulink software. The simulation results show that the response time, power and voltage ripples, and frequency spectrum could be improved significantly by using MPC.
Janůšová, Barbora; Zbytovská, Jarmila; Lorenc, Petr; Vavrysová, Helena; Palát, Karel; Hrabálek, Alexandr; Vávrová, Kateřina
2011-03-01
Stratum corneum ceramides play an essential role in the barrier properties of skin. However, their structure-activity relationships are poorly understood. We investigated the effects of acyl chain length in the non-hydroxy acyl sphingosine type (NS) ceramides on the skin permeability and their thermotropic phase behavior. Neither the long- to medium-chain ceramides (8-24 C) nor free sphingosine produced any changes of the skin barrier function. In contrast, the short-chain ceramides decreased skin electrical impedance and increased skin permeability for two marker drugs, theophylline and indomethacin, with maxima in the 4-6C acyl ceramides. The thermotropic phase behavior of pure ceramides and model stratum corneum lipid membranes composed of ceramide/lignoceric acid/cholesterol/cholesterol sulfate was studied by differential scanning calorimetry and infrared spectroscopy. Differences in thermotropic phase behavior of these lipids were found: those ceramides that had the greatest impact on the skin barrier properties displayed the lowest phase transitions and formed the least dense model stratum corneum lipid membranes at 32°C. In conclusion, the long hydrophobic chains in the NS-type ceramides are essential for maintaining the skin barrier function. However, this ability is not shared by their short-chain counterparts despite their having the same polar head structure and hydrogen bonding ability. Copyright © 2010 Elsevier B.V. All rights reserved.
Full-length model of the human galectin-4 and insights into dynamics of inter-domain communication
Rustiguel, Joane K.; Soares, Ricardo O. S.; Meisburger, Steve P.; Davis, Katherine M.; Malzbender, Kristina L.; Ando, Nozomi; Dias-Baruffi, Marcelo; Nonato, Maria Cristina
2016-09-01
Galectins are proteins involved in diverse cellular contexts due to their capacity to decipher and respond to the information encoded by β-galactoside sugars. In particular, human galectin-4, normally expressed in the healthy gastrointestinal tract, displays differential expression in cancerous tissues and is considered a potential drug target for liver and lung cancer. Galectin-4 is a tandem-repeat galectin characterized by two carbohydrate recognition domains connected by a linker-peptide. Despite their relevance to cell function and pathogenesis, structural characterization of full-length tandem-repeat galectins has remained elusive. Here, we investigate galectin-4 using X-ray crystallography, small- and wide-angle X-ray scattering, molecular modelling, molecular dynamics simulations, and differential scanning fluorimetry assays and describe for the first time a structural model for human galectin-4. Our results provide insight into the structural role of the linker-peptide and shed light on the dynamic characteristics of the mechanism of carbohydrate recognition among tandem-repeat galectins.
Coevoet, Vincent; Fresson, Jeanne; Vieux, Rachel; Jay, Nicolas
2013-06-01
Socioeconomic deprivation is not easily measurable in hospital information systems. However, its identification is essential, as it is associated with morbidity and hospital length of stay (LOS). We aimed at studying the feasibility of using routinely recorded individual and area-based socioeconomic indicators, and assessing their relation with LOS. In a cross-sectional study we collected area-based socioeconomic deprivation indicators from French census databases and individual ones from the 2009 medical and administrative databases of a French referral maternity hospital. The principal outcome was the LOS for delivery. Individual level socioeconomic deprivation indicators included preferential insurance scheme (health insurance allocated to poor persons). Nine area-based socioeconomic deprivation indicators were aggregated at the census tract and commune levels. The relation between socioeconomic deprivation and LOS was studied using multilevel models. The well-documented relation between socioeconomic deprivation and preterm delivery was firstly studied in these models as a validation step. The linkage between aggregated and individual data was possible for the 3471 women included. The median LOS was 5 days. In multivariable analysis adjusted for age (P=0.02), twinning (P=0.0001), delivery mode (Punemployment rate (P=0.002) were associated with an increased LOS. Identifying deprived patients in hospital databases using routinely collected area-based indicators is feasible. The relation of these latter with LOS is consistent with previous studies. Further multicenter investigations are needed to confirm the interest of using such indicators for cost and morbidity predictions.
Modelling command and control teams
Broek, J. van den; Essens, P.J.M.D.; Post, W.M.
2001-01-01
This paper describes a computational approach to modelling and simulating C2-team behaviour. Within this approach team models may be used to develop, test, and compare different C2-architectures, that is different structures and processes, without the need for real teams. The advantage of this metho
无
2010-01-01
In a mountainous region, the glacier area and length extracted form the satellite imagery data is the projected area and length of the land surface, which can’t be representative of the reality; there are always some errors. In this paper, the methods of calculating glacier area and length calculation were put forward based on satellite imagery data and a digital elevation model (DEM). The pure pixels and the mixed pixels were extracted based on the linear spectral un-mixing approach, the slop of the pixels was calculated based on the DEM, then the area calculation method was presented. The projection length was obtained from the satellite imagery data, and the elevation differences was calculated from the DEM. The length calculation method was presented based on the Pythagorean theorem. For a glacier in the study area of western Qilian Mountain, northwestern China, the projected area and length were 140.93 km2 and 30.82 km, respectively. This compares with the results calculated by the methods in this paper, which were 155.16 km2 and 32.11 km respectively, a relative error of the projected area and length extracted from the LandSat Thematic Mapper (TM) image directly reach to -9.2 percent and -4.0 percent, respectively. The calculation method is more in accord with the practicality and can provide reference for some other object’s area and length monitoring in a mountainous region.
Modeling and biological control of mosquitoes.
Lord, Cynthia C
2007-01-01
Models can be useful at many different levels when considering complex issues such as biological control of mosquitoes. At an early stage, exploratory models are valuable in exploring the characteristics of an ideal biological control agent and for guidance in data collection. When more data are available, models can be used to explore alternative control strategies and the likelihood of success. There are few modeling studies that explicitly consider biological control in mosquitoes; however, there have been many theoretical studies of biological control in other insect systems and of mosquitoes and mosquito-borne diseases in general. Examples are used here to illustrate important aspects of designing, using and interpreting models. The stability properties of a model are valuable in assessing the potential of a biological control agent, but may not be relevant to a mosquito population with frequent environmental perturbations. The time scale and goal of proposed control strategies are important considerations when analyzing a model. The underlying biology of the mosquito host and the biological control agent must be carefully considered when deciding what to include in a model. Factors such as density dependent population growth in the host, the searching efficiency and aggregation of a natural enemy, and the resource base of both have been shown to influence the stability and dynamics of the interaction. Including existing mosquito control practices into a model is useful if biological control is proposed for locations with current insecticidal control. The development of Integrated Pest Management (IPM) strategies can be enhanced using modeling techniques, as a wide variety of options can be simulated and examined. Models can also be valuable in comparing alternate routes of disease transmission and to investigate the level of control needed to reduce transmission.
Priyakshi Bezbaruah
2012-01-01
Full Text Available Background: Early mobilization is an important component of physiotherapy used to prevent and decrease pulmonary and immobilization complications, which are the major goals of physiotherapy in the intensive care unit (ICU. Prolonged bed rest and hospitalization leads to deconditioning and weakness which can further increase the length of the ICU stay. This study was conducted to find an answer to whether early mobilization is as effective as or better than routine physiotherapy in reducing the length of ICU stay in mechanically ventilated patients. Study Design: Randomized controlled study. Study Setting: Medical ICU, Father Muller Medical College Hospital. Mangalore, Karnataka, India. Aim: To detect the effectiveness of graded early mobilization and routine physiotherapy and to compare these techniques with respect to the length of ICU stay in mechanically ventilated patients. Materials and Methods: Fifteen subjects of both gender who were on mechanical ventilators fulfilling the inclusion criteria were randomly assigned to two groups, group 1 (graded early mobilization, n = 8 and Group 2 (routine physiotherapy, n = 7 by using the randomization plan from the website www.randomization.com. All the vitals of the subjects were noted as they were made to perform particular maneuvers depending on the group they belonged to. Participants recruited into the early mobilization group were mobilized as soon as their vitals were stable and were able to participate in the therapy. The patients who underwent routine physiotherapy were mobilized once they were extubated. At the time of discharge from the ICU, days of weaning, days first out of bed, and length of ICU stay were noted. Results: A significant difference was observed between early mobilization and routine physiotherapy groups with respect to the length of ICU stay. Conclusion: Early mobilization showed better outcome compared to routine physiotherapy in reducing the length of ICU stay in
Andrieu, Guillaume; Quaranta, Muriel; Leprince, Corinne; Hatzoglou, Anastassia
2012-12-01
Within the Ras superfamily, Gem is a small GTP-binding protein that plays a role in regulating Ca(2+) channels and cytoskeletal remodeling in interphase cells. Here, we report for the first time that Gem is a spindle-associated protein and is required for proper mitotic progression. Functionally, loss of Gem leads to misaligned chromosomes and prometaphase delay. On the basis of different experimental approaches, we demonstrate that loss of Gem by RNA interference induces spindle elongation, while its enforced expression results in spindle shortening. The spindle length phenotype is generated through deregulation of spindle dynamics on Gem depletion and requires the expression of its downstream effector, the kinesin Kif9. Loss of Kif9 induces spindle abnormalities similar to those observed when Gem expression is repressed by siRNA. We further identify Kif9 as a new regulator of spindle dynamics. Kif9 depletion increases the steady-state levels of spindle α-tubulin by increasing the rate of microtubule polymerization. Overall, this study demonstrates a novel mechanism by which Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9.
Modeling, Control and Coordination of Helicopter Systems
Ren, Beibei; Chen, Chang; Fua, Cheng-Heng; Lee, Tong Heng
2012-01-01
Modeling, Control and Coordination of Helicopter Systems provides a comprehensive treatment of helicopter systems, ranging from related nonlinear flight dynamic modeling and stability analysis to advanced control design for single helicopter systems, and also covers issues related to the coordination and formation control of multiple helicopter systems to achieve high performance tasks. Ensuring stability in helicopter flight is a challenging problem for nonlinear control design and development. This book is a valuable reference on modeling, control and coordination of helicopter systems,providing readers with practical solutions for the problems that still plague helicopter system design and implementation. Readers will gain a complete picture of helicopters at the systems level, as well as a better understanding of the technical intricacies involved. This book also: Presents a complete picture of modeling, control and coordination for helicopter systems Provides a modeling platform for a general class of ro...
THE INTERNAL CONTROL MODELS IN ROMANIA
2015-01-01
Internal control is indissolubly linked to business and accounting. Throughout history, domestic and international trade has grown exponentially, which has led to an increasing complexity of internal control, to new methods and techniques to control the business. The literature has presented the first models of internal control in the Sumerian period (3600 - 3200 BC), and the emergence and development of internal control in Egypt, Persia, Greek and Roman Empire, in the Middle Ages...
THE INTERNAL CONTROL MODELS IN ROMANIA
TEODORESCU CRISTIAN DRAGOS
2015-01-01
Internal control is indissolubly linked to business and accounting. Throughout history, domestic and international trade has grown exponentially, which has led to an increasing complexity of internal control, to new methods and techniques to control the business. The literature has presented the first models of internal control in the Sumerian period (3600 - 3200 BC), and the emergence and development of internal control in Egypt, Persia, Greek and Roman Empire, in the Middle Ages till modern...
Model-Based Power Plant Master Control
Boman, Katarina; Thomas, Jean; Funkquist, Jonas
2010-08-15
The main goal of the project has been to evaluate the potential of a coordinated master control for a solid fuel power plant in terms of tracking capability, stability and robustness. The control strategy has been model-based predictive control (MPC) and the plant used in the case study has been the Vattenfall power plant Idbaecken in Nykoeping. A dynamic plant model based on nonlinear physical models was used to imitate the true plant in MATLAB/SIMULINK simulations. The basis for this model was already developed in previous Vattenfall internal projects, along with a simulation model of the existing control implementation with traditional PID controllers. The existing PID control is used as a reference performance, and it has been thoroughly studied and tuned in these previous Vattenfall internal projects. A turbine model was developed with characteristics based on the results of steady-state simulations of the plant using the software EBSILON. Using the derived model as a representative for the actual process, an MPC control strategy was developed using linearization and gain-scheduling. The control signal constraints (rate of change) and constraints on outputs were implemented to comply with plant constraints. After tuning the MPC control parameters, a number of simulation scenarios were performed to compare the MPC strategy with the existing PID control structure. The simulation scenarios also included cases highlighting the robustness properties of the MPC strategy. From the study, the main conclusions are: - The proposed Master MPC controller shows excellent set-point tracking performance even though the plant has strong interactions and non-linearity, and the controls and their rate of change are bounded. - The proposed Master MPC controller is robust, stable in the presence of disturbances and parameter variations. Even though the current study only considered a very small number of the possible disturbances and modelling errors, the considered cases are
THE INTERNAL CONTROL MODELS IN ROMANIA
TEODORESCU CRISTIAN DRAGOȘ
2015-06-01
Full Text Available Internal control is indissolubly linked to business and accounting. Throughout history, domestic and international trade has grown exponentially, which has led to an increasing complexity of internal control, to new methods and techniques to control the business. The literature has presented the first models of internal control in the Sumerian period (3600 - 3200 BC, and the emergence and development of internal control in Egypt, Persia, Greek and Roman Empire, in the Middle Ages till modern times. The purpose of this article is to present the models of internal control in Romania, starting from the principles of the classical model of internal control (COSO model. For a better understanding of the implication of internal control in terms of public and private sector, I have structured the article in the following parts: (a the definition of internal control in the literature; (b the presentation of the COSO model; (c internal control and internal audit in public institutions; (d internal control issues in accounting regulations on the individual and consolidated annual financial statements; (e internal / managerial control; (f conclusions.
Larsen, Christian; Turkensteen, Marcel
2014-01-01
We consider a vendor that supplies a set of geographically dispersed retailers and that can monitor the inventory levels at the retailers. Such an arrangement is often called Vendor Managed Inventory (VMI). The dispatch of a vehicle is made to a fixed group of retailers. Normally, the inventory...... levels at the vendor’s warehouse and at the retailers are established by modeling the problem as a Joint Replenishment Problem (JRP). This fixed set-up cost ignores the differences in distances, number of retailers visited and vehicle load that may occur, in particular when these retailers are served...
ROBUST INTERNAL MODEL CONTROL STRATEGY BASED PID CONTROLLER FOR BLDCM
A.PURNA CHANDRA RAO
2010-11-01
Full Text Available All the closed loop control system requires the controller for improvement of transient response of the error signal. Though the tuning of PID controller in real time is bit difficult and moreover it lacks the disturbance rejection capability. This paper presents a tuning of PID parameters based on internal model strategy. The advantageous of the proposed control strategy is well described in the paper. To test the validity of the proposed control, it is implemented in brushless dc motor drive. The mathematical model of brushless dc motor (BLDC is presented for control design. In addition the robustness of the control strategy is discussed. The proposed control strategy possesses good transient responses and good load disturbance response. In addition, the proposed control strategy possesses good tracking ability. To test the effectiveness of the proposed strategy, the BLDC is represented in transfer function model and later implemented in test system. The results are presented to validate the proposed control strategy for BLDC drive.
Fault Tolerant Control Using Gaussian Processes and Model Predictive Control
Yang Xiaoke
2015-03-01
Full Text Available Essential ingredients for fault-tolerant control are the ability to represent system behaviour following the occurrence of a fault, and the ability to exploit this representation for deciding control actions. Gaussian processes seem to be very promising candidates for the first of these, and model predictive control has a proven capability for the second. We therefore propose to use the two together to obtain fault-tolerant control functionality. Our proposal is illustrated by several reasonably realistic examples drawn from flight control.
Cummings, Damian M; Alaghband, Yasaman; Hickey, Miriam A; Joshi, Prasad R; Hong, S Candice; Zhu, Chunni; Ando, Timothy K; André, Véronique M; Cepeda, Carlos; Watson, Joseph B; Levine, Michael S
2012-01-01
The R6/2 mouse is the most frequently used model for experimental and preclinical drug trials in Huntington's disease (HD). When the R6/2 mouse was first developed, it carried exon 1 of the huntingtin gene with ~150 cytosine-adenine-guanine (CAG) repeats. The model presented with a rapid and aggressive phenotype that shared many features with the human condition and was particularly similar to juvenile HD. However, instability in the CAG repeat length due to different breeding practices has led to both decreases and increases in average CAG repeat lengths among colonies. Given the inverse relationship in human HD between CAG repeat length and age at onset and to a degree, the direct relationship with severity of disease, we have investigated the effect of altered CAG repeat length. Four lines, carrying ~110, ~160, ~210, and ~310 CAG repeats, were examined using a battery of tests designed to assess the basic R6/2 phenotype. These included electrophysiological properties of striatal medium-sized spiny neurons, motor activity, inclusion formation, and protein expression. The results showed an unpredicted, inverted "U-shaped" relationship between CAG repeat length and phenotype; increasing the CAG repeat length from 110 to 160 exacerbated the R6/2 phenotype, whereas further increases to 210 and 310 CAG repeats greatly ameliorated the phenotype. These findings demonstrate that the expected relationship between CAG repeat length and disease severity observed in humans is lost in the R6/2 mouse model and highlight the importance of CAG repeat-length determination in preclinical drug trials that use this model.
2011-05-10
...; Door 1 Extendable Length Escape Slide AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... extendable length escape slide. The applicable airworthiness regulations do not contain adequate or... unusual design features: The 747-8 design offers seating capacity on two separate decks, the main...
Ground Wood Fiber Length Distributions
Lauri Ilmari Salminen
2014-01-01
Full Text Available This study considers ground wood fiber length distributions arising from pilot grindings. The empirical fiber length distributions appear to be independent of wood fiber length as well as feeding velocity. In terms of mathematics the fiber fragment distributions of ground wood pulp combine an exponential distribution for high-length fragments and a power-law distribution for smaller lengths. This implies that the fiber length distribution is influenced by the stone surface. A fragmentation-based model is presented that allows reproduction of the empirical results.
Model predictive control of MSMPR crystallizers
Moldoványi, Nóra; Lakatos, Béla G.; Szeifert, Ferenc
2005-02-01
A multi-input-multi-output (MIMO) control problem of isothermal continuous crystallizers is addressed in order to create an adequate model-based control system. The moment equation model of mixed suspension, mixed product removal (MSMPR) crystallizers that forms a dynamical system is used, the state of which is represented by the vector of six variables: the first four leading moments of the crystal size, solute concentration and solvent concentration. Hence, the time evolution of the system occurs in a bounded region of the six-dimensional phase space. The controlled variables are the mean size of the grain; the crystal size-distribution and the manipulated variables are the input concentration of the solute and the flow rate. The controllability and observability as well as the coupling between the inputs and the outputs was analyzed by simulation using the linearized model. It is shown that the crystallizer is a nonlinear MIMO system with strong coupling between the state variables. Considering the possibilities of the model reduction, a third-order model was found quite adequate for the model estimation in model predictive control (MPC). The mean crystal size and the variance of the size distribution can be nearly separately controlled by the residence time and the inlet solute concentration, respectively. By seeding, the controllability of the crystallizer increases significantly, and the overshoots and the oscillations become smaller. The results of the controlling study have shown that the linear MPC is an adaptable and feasible controller of continuous crystallizers.
Flexible AC transmission systems modelling and control
Zhang, Xiao-Ping; Pal, Bikash
2012-01-01
The extended and revised second edition of this successful monograph presents advanced modeling, analysis and control techniques of Flexible AC Transmission Systems (FACTS). The book covers comprehensively a range of power-system control problems: from steady-state voltage and power flow control, to voltage and reactive power control, to voltage stability control, to small signal stability control using FACTS controllers. In the six years since the first edition of the book has been published research on the FACTS has continued to flourish while renewable energy has developed into a mature and
Model predictive control for cooperative control of space robots
Kannan, Somasundar; Alamdari, Seyed Amin Sajadi; Dentler, Jan; Olivares-Mendez, Miguel A.; Voos, Holger
2017-01-01
The problem of Orbital Manipulation of Passive body is discussed here. Two scenarios including passive object rigidly attached to robotic servicers and passive body attached to servicers through manipulators are discussed. The Model Predictive Control (MPC) technique is briefly presented and successfully tested through simulations on two cases of position control of passive body in the orbit.
Cavity length below chute aerators
2008-01-01
It is proved that air entrainment is one of the efficient measures dealing with cavi-tation control for the release works of hydropower projects. There are many factors to be considered in designing a chute aerator. One of the most important factors concerns the cavity length below the aerator,which has outstanding effects on air entrainment against cavitation damage. It is crucial to determine reasonable emergence angle for the calculation of the cavity length. In the present paper the overall effects of structural and hydraulic parameters on the emergence angle of the flow from the aerator were analyzed. Four improved expressions of the emer-gence angle with weight coefficient were investigated through experimental data of 68 points observed from 12 aerators of 6 hydropower projects,of both model and prototype,on the basis of error theory. A method to calculate the cavity length be-low aerators was suggested,which considers overall effects of the above men-tioned parameters. Comparison between the method in this paper and the other five methods of calculating the cavity length showed that the present method is much more reliable than the existing methods while the mean error of the method is less than others.
Cavity length below chute aerators
WU JianHua; RUAN ShiPing
2008-01-01
It is proved that air entrainment is one of the efficient measures dealing with cavitation control for the release works of hydropower projects. There are many factors to be considered in designing a chute aerator. One of the most important factors concerns the cavity length below the aerator, which has outstanding effects on air entrainment against cavitation damage. It is crucial to determine reasonable emergence angle for the calculation of the cavity length. In the present paper the overall effects of structural and hydraulic parameters on the emergence angle of the flow from the aerator were analyzed. Four improved expressions of the emergence angle with weight coefficient were investigated through experimental data of 68 points observed from 12 aerators of 6 hydropower projects, of both model and prototype, on the basis of error theory. A method to calculate the cavity length below aerators was suggested, which considers overall effects of the above mentioned parameters. Comparison between the method in this paper and the other five methods of calculating the cavity length showed that the present method is much more reliable than the existing methods while the mean error of the method is less than others.
Rona-Voros, Krisztina; Eschbach, Judith; Vernay, Aurélia; Wiesner, Diana; Schwalenstocker, Birgit; Geniquet, Pauline; Mousson De Camaret, Bénédicte; Echaniz-Laguna, Andoni; Loeffler, Jean-Philippe; Ludolph, Albert C; Weydt, Patrick; Dupuis, Luc
2013-12-20
Increased mitochondrial mass, commonly termed mitochondrial proliferation, is frequently observed in many human diseases directly or indirectly involving mitochondrial dysfunction. Mitochondrial proliferation is thought to counterbalance a compromised energy metabolism, yet it might also be detrimental through alterations of mitochondrial regulatory functions such as apoptosis, calcium metabolism or oxidative stress. Here, we show that prominent mitochondrial proliferation occurs in Cramping mice, a model of hereditary neuropathy caused by a mutation in the dynein heavy chain gene Dync1h1. The mitochondrial proliferation correlates with post-prandial induction of full-length (FL) and N-terminal truncated (NT) isoforms of the transcriptional co-activator PGC-1α. The selective knock-out of FL-PGC-1α isoform, preserving expression and function of NT-PGC-1α, led to a complete reversal of mitochondrial proliferation. Moreover, FL-PGC-1α ablation potently exacerbated the mitochondrial dysfunction and led to severe weight loss. Finally, FL-PGC-1α ablation triggered pronounced locomotor dysfunction, tremors and inability to rear in Cramping mice. In summary, endogenous FL-PGC-1α activates mitochondrial proliferation and salvages neurological and metabolic health upon disease. NT-PGC-1α cannot fulfil this protective action. Activation of this endogenous salvage pathway might thus be a valuable therapeutic target for diseases involving mitochondrial dysfunction.
Model based development of engine control algorithms
Dekker, H.J.; Sturm, W.L.
1996-01-01
Model based development of engine control systems has several advantages. The development time and costs are strongly reduced because much of the development and optimization work is carried out by simulating both engine and control system. After optimizing the control algorithm it can be executed b
Model Predictive Control of Sewer Networks
Pedersen, Einar B.; Herbertsson, Hannes R.; Niemann, Henrik; Poulsen, Niels K.; Falk, Anne K. V.
2017-01-01
The developments in solutions for management of urban drainage are of vital importance, as the amount of sewer water from urban areas continues to increase due to the increase of the world’s population and the change in the climate conditions. How a sewer network is structured, monitored and controlled have thus become essential factors for effcient performance of waste water treatment plants. This paper examines methods for simplified modelling and controlling a sewer network. A practical approach to the problem is used by analysing simplified design model, which is based on the Barcelona benchmark model. Due to the inherent constraints the applied approach is based on Model Predictive Control.
Giulia Morra
2009-03-01
Full Text Available Hsp90 is a molecular chaperone essential for protein folding and activation in normal homeostasis and stress response. ATP binding and hydrolysis facilitate Hsp90 conformational changes required for client activation. Hsp90 plays an important role in disease states, particularly in cancer, where chaperoning of the mutated and overexpressed oncoproteins is important for function. Recent studies have illuminated mechanisms related to the chaperone function. However, an atomic resolution view of Hsp90 conformational dynamics, determined by the presence of different binding partners, is critical to define communication pathways between remote residues in different domains intimately affecting the chaperone cycle. Here, we present a computational analysis of signal propagation and long-range communication pathways in Hsp90. We carried out molecular dynamics simulations of the full-length Hsp90 dimer, combined with essential dynamics, correlation analysis, and a signal propagation model. All-atom MD simulations with timescales of 70 ns have been performed for complexes with the natural substrates ATP and ADP and for the unliganded dimer. We elucidate the mechanisms of signal propagation and determine "hot spots" involved in interdomain communication pathways from the nucleotide-binding site to the C-terminal domain interface. A comprehensive computational analysis of the Hsp90 communication pathways and dynamics at atomic resolution has revealed the role of the nucleotide in effecting conformational changes, elucidating the mechanisms of signal propagation. Functionally important residues and secondary structure elements emerge as effective mediators of communication between the nucleotide-binding site and the C-terminal interface. Furthermore, we show that specific interdomain signal propagation pathways may be activated as a function of the ligand. Our results support a "conformational selection model" of the Hsp90 mechanism, whereby the protein may
Gwenn Le Mée
Full Text Available Evidence for an RNA gain-of-function toxicity has now been provided for an increasing number of human pathologies. Myotonic dystrophies (DM belong to a class of RNA-dominant diseases that result from RNA repeat expansion toxicity. Specifically, DM of type 1 (DM1, is caused by an expansion of CUG repeats in the 3'UTR of the DMPK protein kinase mRNA, while DM of type 2 (DM2 is linked to an expansion of CCUG repeats in an intron of the ZNF9 transcript (ZNF9 encodes a zinc finger protein. In both pathologies the mutant RNA forms nuclear foci. The mechanisms that underlie the RNA pathogenicity seem to be rather complex and not yet completely understood. Here, we describe Drosophila models that might help unravelling the molecular mechanisms of DM1-associated CUG expansion toxicity. We generated transgenic flies that express inducible repeats of different type (CUG or CAG and length (16, 240, 480 repeats and then analyzed transgene localization, RNA expression and toxicity as assessed by induced lethality and eye neurodegeneration. The only line that expressed a toxic RNA has a (CTG(240 insertion. Moreover our analysis shows that its level of expression cannot account for its toxicity. In this line, (CTG(240.4, the expansion inserted in the first intron of CG9650, a zinc finger protein encoding gene. Interestingly, CG9650 and (CUG(240.4 expansion RNAs were found in the same nuclear foci. In conclusion, we suggest that the insertion context is the primary determinant for expansion toxicity in Drosophila models. This finding should contribute to the still open debate on the role of the expansions per se in Drosophila and in human pathogenesis of RNA-dominant diseases.
Kamchevska, Valerija; Cristofori, Valentina; Da Ros, Francesco
2016-01-01
We propose and demonstrate an algorithm that allows for automatic synchronization of SDN-controlled all-optical TDM switching nodes connected in a ring network. We experimentally show successful WDM-SDM transmission of data bursts between all ring nodes.......We propose and demonstrate an algorithm that allows for automatic synchronization of SDN-controlled all-optical TDM switching nodes connected in a ring network. We experimentally show successful WDM-SDM transmission of data bursts between all ring nodes....
Coelho, Luís; Cardoso, Hugo F V
2013-12-10
Timing of blunt force trauma in human bone is a critical forensic issue, but there is limited knowledge on how different environmental conditions, the duration of postmortem interval (PMI), different bone types and different animal models influence fracture morphology. This study aims at evaluating the influence of the type of postmortem environment and the duration of the postmortem period on fracture morphology, for distinguishing perimortem from postmortem fractures on different types of long bones from different species. Fresh limb segments from pig and goat were sequentially left to decompose, under 3 different environmental circumstances (surface, buried and submerged), resulting in sets with different PMI lengths (0, 28, 56, 84, 112, 140, 168 and 196 days), which were then fractured. Fractured bones (total=325; pig tibia=110; pig fibula=110; goat metatarsals=105) were classified according to the Fracture Freshness Index (FFI). Climatic data for the experiment location was collected. Statistical analysis included descriptive statistics, correlation analysis between FFI and PMI, Mann-Whitney U tests comparing FFI medians for different PMI's and linear regression analysis using PMI, pluviosity and temperature as predictors for FFI. Surface samples presented increases in FFI with increasing PMI, with positive correlations for all bone types. The same results were observed in submerged samples, except for pig tibia. Median FFI values for surface samples could distinguish bones with PMI=0 days from PMI≥56 days. Buried samples presented no significant correlation between FFI and PMI, and nonsignificant regression models. Regression analysis of surface and submerged samples suggested differences in FFI variation with PMI between bone types, although without statistical significance. Adding climatic data to surface regression models resulted in PMI no longer predicting FFI. When comparing different animal models, linear regressions suggested greater increases in
Multiple models adaptive feedforward decoupling controller
Wang Xin; Li Shaoyuan; Wang Zhongjie
2005-01-01
When the parameters of the system change abruptly, a new multivariable adaptive feedforward decoupling controller using multiple models is presented to improve the transient response. The system models are composed of multiple fixed models, one free-running adaptive model and one re-initialized adaptive model. The fixed models are used to provide initial control to the process. The re-initialized adaptive model can be reinitialized as the selected model to improve the adaptation speed. The free-running adaptive controller is added to guarantee the overall system stability. At each instant, the best system model is selected according to the switching index and the corresponding controller is designed. During the controller design, the interaction is viewed as the measurable disturbance and eliminated by the choice of the weighting polynomial matrix. It not only eliminates the steady-state error but also decouples the system dynamically. The global convergence is obtained and several simulation examples are presented to illustrate the effectiveness of the proposed controller.
Lefebre, Matthew D; Galán, Jorge E
2014-01-14
Type III secretion machines are essential for the biology of many bacteria that are pathogenic or symbiotic for animals, plants, or insects. They exert their function by delivering bacterial effector proteins into target eukaryotic cells. The core component of these machines is the needle complex, a multiprotein structure that spans the bacterial envelope and serves as a conduit for proteins that transit this secretion pathway. The needle complex is composed of a multiring base embedded in the bacterial envelope and a filament-like structure, the needle, that projects from the bacterial surface and is linked to the base by the inner rod. Assembly of the needle complex proceeds in a step-wise fashion that is initiated by the assembly of the base and is followed by the export of the building subunits for the needle and inner rod substructures. Once assembled, the needle complex reprograms its specificity and becomes competent for the secretion of effector proteins. Here through genetic, biochemical, and electron microscopy analyses of the Salmonella inner rod protein subunit PrgJ we present evidence that the assembly of the inner rod dictates the timing of substrate switching and needle length. Furthermore, the identification of mutations in PrgJ that specifically alter the hierarchy of protein secretion provides additional support for a complex role of the inner rod substructure in type III secretion.
Ishizawa, Atsushi; Goto, Takahiro; Kou, Rai; Tsuchizawa, Tai; Matsuda, Nobuyuki; Hitachi, Kenichi; Nishikawa, Tadashi; Yamada, Koji; Sogawa, Tetsuomi; Gotoh, Hideki
2017-07-01
We demonstrate on-chip octave-spanning supercontinuum (SC) generation with a Si-wire waveguide (SWG). We precisely controlled the SWG width so that the group velocity becomes flat over a wide wavelength range. By adjusting the SWG length, we could reduce the optical losses due to two-photon absorption and pulse propagation. In addition, for efficient coupling between the laser pulse and waveguide, we fabricated a two-step inverse taper at both ends of the SWG. Using a 600-nm-wide SWG, we were able to generate a broadband SC spectrum at wavelengths from 1060 to 2200 nm at a -40 dB level with only 50-pJ laser energy from an Er-doped fiber laser oscillator. We found that we can generate an on-chip broadband SC spectrum with an SWG with a length even as small as 1.7 mm.
Modeling, Estimation, and Control of Helicopter Slung Load System
Bisgaard, Morten
This thesis treats the subject of autonomous helicopter slung load flight and presents the reader with a methodology describing the development path from modeling and system analysis over sensor fusion and state estimation to controller synthesis. The focus is directed along two different....... To enable slung load flight capabilities for general cargo transport, an integrated estimation and control system is developed for use on already autonomous helicopters. The estimator uses vision based updates only and needs little prior knowledge of the slung load system as it estimates the length...... of the suspension system together with the system states. The controller uses a combined feedforward and feedback approach to simultaneously prevent exciting swing and to actively dampen swing in the slung load. For the mine detection application an estimator is developed that provides full system state information...
Model predictive control classical, robust and stochastic
Kouvaritakis, Basil
2016-01-01
For the first time, a textbook that brings together classical predictive control with treatment of up-to-date robust and stochastic techniques. Model Predictive Control describes the development of tractable algorithms for uncertain, stochastic, constrained systems. The starting point is classical predictive control and the appropriate formulation of performance objectives and constraints to provide guarantees of closed-loop stability and performance. Moving on to robust predictive control, the text explains how similar guarantees may be obtained for cases in which the model describing the system dynamics is subject to additive disturbances and parametric uncertainties. Open- and closed-loop optimization are considered and the state of the art in computationally tractable methods based on uncertainty tubes presented for systems with additive model uncertainty. Finally, the tube framework is also applied to model predictive control problems involving hard or probabilistic constraints for the cases of multiplic...
Weiland, J., E-mail: elfjw@chalmers.se [Chalmers University of Technology and EURATOM-VR Association (Sweden)
2016-05-15
Basic aspects of turbulent transport in toroidal magnetized plasmas are discussed. In particular the fluid closure has strong effects on zonal flows which are needed to create an absorbing boundary for long wave lengths and also to obtain the Dimits nonlinear upshift. The fluid resonance in the energy equation is found to be instrumental for generating the L–H transition, the spin-up of poloidal rotation in internal transport barriers, as well as the nonlinear Dimits upshift. The difference between the linearly fastest growing mode number and the corresponding longer nonlinear correlation length is also addressed. It is found that the Kadomtsev mixing length result is consistent with the non-Markovian diagonal limit of the transport at the nonlinearly obtained correlation length.
Remote control missile model test
Allen, Jerry M.; Shaw, David S.; Sawyer, Wallace C.
1989-01-01
An extremely large, systematic, axisymmetric body/tail fin data base was gathered through tests of an innovative missile model design which is described herein. These data were originally obtained for incorporation into a missile aerodynamics code based on engineering methods (Program MISSILE3), but can also be used as diagnostic test cases for developing computational methods because of the individual-fin data included in the data base. Detailed analysis of four sample cases from these data are presented to illustrate interesting individual-fin force and moment trends. These samples quantitatively show how bow shock, fin orientation, fin deflection, and body vortices can produce strong, unusual, and computationally challenging effects on individual fin loads. Comparisons between these data and calculations from the SWINT Euler code are also presented.
Langhans, Christoph; Engels, Lien; Tegenbos, Lize; Govers, Gerard; Diels, Jan
2010-05-01
Rainfall simulation on small field plots is an invaluable method to derive effective field parameters for infiltration models such as Green-Ampt. Plot scales of ca. 1m² integrate much of the micro-scale variability and processes, which ring-infiltrometers or soil core measurements cannot capture. However, these parameters have to be used with caution on larger scales, because processes such as run-on infiltration can be considerable. The Green-Ampt parameters suction across the wetting front (psi) and effective hydraulic conductivity (Ke) were estimated from rainfall simulations on two ridged fields in Togo, West Africa. Additionally, rainfall events were recorded, and on plots of 1m width and lengths of 1, 4 and 16m, total runoff volume and sediment concentration were measured. The storm runoff hydrographs of the plots were modelled with Chu's Green-Ampt variable rainfall intensity infiltration model, using the field-average parameters derived from the simulations. Potential effects of runoff lag time were assumed negligible. Calculated total runoff volumes were compared to measured runoff volumes. For the 1m plots, runoff was underestimated, as patches of seal in the furrows produced runoff already at rainfall intensities much lower than the average infiltration capacity. For the longer plots, no run-on infiltration or other scale dependent processes were assumed, so the relative error due to scale effects was proportional to the average difference or runoff depth. In contrast to the 1m plots, runoff was overestimated by a factor of 1.2 and 2 for the 4m and 16m plots, respectively. It appears that the application of the Green-Ampt effective hydraulic conductivity derived from rainfall simulations faces two main problems, which are their dependence on one single rainfall intensity and scale-effects by run-on infiltration. Errors necessarily propagate into the scale dependency of erosion and sediment transport, as these processes are directly dependent on runoff
Information modeling system for blast furnace control
Spirin, N. A.; Gileva, L. Y.; Lavrov, V. V.
2016-09-01
Modern Iron & Steel Works as a rule are equipped with powerful distributed control systems (DCS) and databases. Implementation of DSC system solves the problem of storage, control, protection, entry, editing and retrieving of information as well as generation of required reporting data. The most advanced and promising approach is to use decision support information technologies based on a complex of mathematical models. The model decision support system for control of blast furnace smelting is designed and operated. The basis of the model system is a complex of mathematical models created using the principle of natural mathematical modeling. This principle provides for construction of mathematical models of two levels. The first level model is a basic state model which makes it possible to assess the vector of system parameters using field data and blast furnace operation results. It is also used to calculate the adjustment (adaptation) coefficients of the predictive block of the system. The second-level model is a predictive model designed to assess the design parameters of the blast furnace process when there are changes in melting conditions relative to its current state. Tasks for which software is developed are described. Characteristics of the main subsystems of the blast furnace process as an object of modeling and control - thermal state of the furnace, blast, gas dynamic and slag conditions of blast furnace smelting - are presented.
Wind farm models and control strategies
Soerensen, Poul; Hansen, Anca D.; Iov, F.; Blaabjerg, F.; Donovan, M.H.
2005-08-01
This report describes models and control strategies for 3 different concepts of wind farms. Initially, the potential in improvement of grid integration, structural loads and energy production is investigated in a survey of opportunities. Then simulation models are described, including wind turbine models for a fixed speed wind turbine with active stall control and a variable speed wind turbine with doubly-fed induction generator. After that, the 3 wind farm concepts and control strategies are described. The 3 concepts are AC connected doubly fed turbines, AC connected active stall turbines and DC connected active stall turbines. Finally, some simulation examples and conclusions are presented. (au)
Development and Integration of Control System Models
Kim, Young K.
1998-01-01
The computer simulation tool, TREETOPS, has been upgraded and used at NASA/MSFC to model various complicated mechanical systems and to perform their dynamics and control analysis with pointing control systems. A TREETOPS model of Advanced X-ray Astrophysics Facility - Imaging (AXAF-1) dynamics and control system was developed to evaluate the AXAF-I pointing performance for Normal Pointing Mode. An optical model of Shooting Star Experiment (SSE) was also developed and its optical performance analysis was done using the MACOS software.
Modeling, Optimization & Control of Hydraulic Networks
Tahavori, Maryamsadat
2014-01-01
to check if the network is controllable. Afterward the pressure control problem in water supply systems is formulated as an optimal control problem. The goal is to minimize the power consumption in pumps and also to regulate the pressure drop at the end-users to a desired value. The formulated optimal...... in water network is pressure management. By reducing the pressure in the water network, the leakage can be reduced significantly. Also it reduces the amount of energy consumption in water networks. The primary purpose of this work is to develop control algorithms for pressure control in water supply...... systems. To have better understanding of water leakage, to control pressure and leakage effectively and for optimal design of water supply system, suitable modeling is an important prerequisite. Therefore a model with the main objective of pressure control and consequently leakage reduction is presented...
Modelling supervisory controller for hybrid power systems
Pereira, A.; Bindner, H.; Lundsager, P. [Risoe National Lab., Roskilde (Denmark); Jannerup, O. [Technical Univ. of Denmark, Dept. of Automation, Lyngby (Denmark)
1999-03-01
Supervisory controllers are important to achieve optimal operation of hybrid power systems. The performance and economics of such systems depend mainly on the control strategy for switching on/off components. The modular concept described in this paper is an attempt to design standard supervisory controllers that could be used in different applications, such as village power and telecommunication applications. This paper presents some basic aspects of modelling and design of modular supervisory controllers using the object-oriented modelling technique. The functional abstraction hierarchy technique is used to formulate the control requirements and identify the functions of the control system. The modular algorithm is generic and flexible enough to be used with any system configuration and several goals (different applications). The modularity includes accepting modification of system configuration and goals during operation with minor or no changes in the supervisory controller. (au)
Robust control of an aircraft model
Werner, H. [Bochum Univ. (Germany). Fakultaet fuer Elektrotechnik
1999-12-01
A new multimodel approach to robust controller design is illustrated by a practical application: for a laboratory aircraft model, a robust controller is designed simultaneously for normal operating conditions and for propeller failure. Based on a linear model for each operating mode, an LMI formulation of the problem and convex programming are used to search for a state feedback controller which achieves the objective. This state feedback design is then realized simultaneously in both operating modes by a controller which is based on fast output sampling. Robust performance is demonstrated by experimental results. (orig.)
Robust control of an aircraft model
Werner, H. (Bochum Univ. (Germany). Fakultaet fuer Elektrotechnik)
1999-01-01
A new multimodel approach to robust controller design is illustrated by a practical application: for a laboratory aircraft model, a robust controller is designed simultaneously for normal operating conditions and for propeller failure. Based on a linear model for each operating mode, an LMI formulation of the problem and convex programming are used to search for a state feedback controller which achieves the objective. This state feedback design is then realized simultaneously in both operating modes by a controller which is based on fast output sampling. Robust performance is demonstrated by experimental results. (orig.)
Callahan, Joshua W; Abercrombie, Elizabeth D
2011-01-01
Huntington's disease (HD) is characterized by numerous alterations within the corticostriatal circuitry. The striatum is innervated by a dense array of dopaminergic (DA) terminals and these DA synapses are critical to the proper execution of motor functions. As motor disturbances are prevalent in HD we examined DA neurotransmission in the striatum in transgenic (tg) murine models of HD. We used in vivo microdialysis to compare extracellular concentrations of striatal DA in both a fragment (R6/2) model, which displays a rapid and severe phenotype, and a full-length (YAC128) model that expresses a more progressive phenotype. Extracellular striatal DA concentrations were significantly reduced in R6/2 mice and decreased concomitantly with age-dependent increasing motor impairments on the rotarod task (7, 9, and 11 weeks). In a sample of 11-week-old R6/2 mice, we also measured tissue concentrations of striatal DA and found that total levels of DA were significantly depleted. However, the loss of total DA content (<50%) was insufficient to account for the full extent of DA depletion in the extracellular fluid (ECF; ∼75%). We also observed a significant reduction in extracellular DA concentrations in the striatum of 7-month-old YAC128 mice. In a separate set of experiments, we applied d-amphetamine (AMPH; 10 μm) locally into the striatum to stimulate the release of intracellular DA into the ECF. The AMPH-induced increase in extracellular DA levels was significantly blunted in 9-week-old R6/2 mice. There also was a decrease in AMPH-stimulated DA efflux in 7-month-old YAC128 mice in comparison to WT controls, although the effect was milder. In the same cohort of 7-month-old YAC128 mice we observed a significant reduction in the total locomotor activity in response to systemic AMPH (2 mg/kg). Our data demonstrate that extracellular DA release is attenuated in both a fragment and full-length tg mouse model of HD and support the concept of DA involvement in aspects of
Contrast Gain Control Model Fits Masking Data
Watson, Andrew B.; Solomon, Joshua A.; Null, Cynthia H. (Technical Monitor)
1994-01-01
We studied the fit of a contrast gain control model to data of Foley (JOSA 1994), consisting of thresholds for a Gabor patch masked by gratings of various orientations, or by compounds of two orientations. Our general model includes models of Foley and Teo & Heeger (IEEE 1994). Our specific model used a bank of Gabor filters with octave bandwidths at 8 orientations. Excitatory and inhibitory nonlinearities were power functions with exponents of 2.4 and 2. Inhibitory pooling was broad in orientation, but narrow in spatial frequency and space. Minkowski pooling used an exponent of 4. All of the data for observer KMF were well fit by the model. We have developed a contrast gain control model that fits masking data. Unlike Foley's, our model accepts images as inputs. Unlike Teo & Heeger's, our model did not require multiple channels for different dynamic ranges.
An Efficient Implementation of Partial Condensing for Nonlinear Model Predictive Control
Frison, Gianluca; Kouzoupis, Dimitris; Jørgensen, John Bagterp
2016-01-01
Partial (or block) condensing is a recently proposed technique to reformulate a Model Predictive Control (MPC) problem into a form more suitable for structure-exploiting Quadratic Programming (QP) solvers. It trades off horizon length for input vector size, and this degree of freedom can be emplo......Partial (or block) condensing is a recently proposed technique to reformulate a Model Predictive Control (MPC) problem into a form more suitable for structure-exploiting Quadratic Programming (QP) solvers. It trades off horizon length for input vector size, and this degree of freedom can...
Panaite, P.A.; Kuntzer, T; Gourdon, G; Barakat-Walter, I.
2013-01-01
Myotonic dystrophy (DM1) is a multisystemic disease caused by an expansion of CTG repeats in the region of DMPK, the gene encoding DM protein kinase. The severity of muscle disability in DM1 correlates with the size of CTG expansion. As respiratory failure is one of the main causes of death in DM1, we investigated the correlation between respiratory impairment and size of the (CTG)n repeat in DM1 animal models. Using pressure plethysmography the respiratory function was assessed in control an...
Gill, Wonpyong
2016-08-01
In a previous study, the crossing time for the overdominant case in an infinite population was found to be saturated at a long sequence length in the diploid, coupled, discrete-time, mutation-selection model. The present study focused on the effect of a finite population size on the crossing time for the overdominant case. The dependence of the crossing time on the sequence length was simulated for a range of dominance parameters and selective advantages by switching on a diploid, asymmetric, bridged landscape from an initial state, a steady state in a diploid, bridged landscape. The boundary between the deterministic and the stochastic regions in the diploid, coupled, discrete-time, mutation-selection model was characterized using the same formula as that in the haploid, coupled, discrete-time, mutation-selection model. The crossing time in a finite population with various population sizes, dominance parameters and selective advantages began to deviate from the crossing time for an infinite population at a critical sequence length. The crossing time for a finite population in the stochastic region was found to be an exponentially increasing function of the sequence length, whose rate was unchanged, regardless of changes in the population size, dominance parameter and selective advantage with a fixed extension parameter. Therefore, the saturation of the crossing time at a long sequence length, which was observed for the overdominant case in an infinite population, could not be realized for a finite population.
Wind turbine control and model predictive control for uncertain systems
Thomsen, Sven Creutz
as disturbance models for controller design. The theoretical study deals with Model Predictive Control (MPC). MPC is an optimal control method which is characterized by the use of a receding prediction horizon. MPC has risen in popularity due to its inherent ability to systematically account for time......-domain constraints on signals. During the last decades several theoretical advances have been made, so that it can handle a wide variety of system structures. In this thesis, the focus is on handling uncertain linear system description. To this end the so-called Youla parameterizations have been used. Two methods...... are proposed: The first method exploits the modularity of the parameterizations so that the uncertainty can be identified and the MPC controller can be reconfigured in a modular setting. The second method is a robust MPC method in which the Youla parameters are used as an integral part of the online...
Ashby, R D; Solaiman, D K; Foglia, T A; Liu, C K
2001-01-01
Glucose-triacylglycerol (TAG) mixed substrates were used to modulate the physical and mechanical properties of medium-chain-length poly(hydroxyalkanoates) (mcl-PHAs). Pseudomonas resinovorans NRRL B-2649 grew and produced mcl-PHAs on glucose and TAGs (coconut oil, C; soybean oil, S) after 24 h in a shake flask culture. However, with the exception of coconut oil, maximum cell productivity was not reached in any of the cultures until 72 h post-inoculation. Here, 50:50 mixtures of glucose and coconut oil (glc/C) or glucose and soybean oil (glc/S) resulted in intermediate cell productivities with a maximum of 57% and 48% of the CDW at 72 h, respectively. In addition, mixed substrates resulted in mcl-PHAs with compositions that varied slightly over time. PHA-glc/C and PHA-glc/S were composed of 7 mol % and 8 mol % 3-hydroxydodecenoic acid (C(12:1)), respectively at 72 h. These concentrations were intermediate to the C(12:1) concentration of PHA-glc and respective PHA-TAG. Also, significant amounts of 3-hydroxytetradecanoic acid (C(14:0)), 3-hydroxytetradecenoic acid (C(14:1)), and 3-hydroxytetradecadienoic acid (C(14:2)) were present in PHA-glc/C and PHA-glc/S, which were derived from the respective TAG, as glucose resulted in almost no C(14:)(X) monomers. The molar masses of each of the polymers remained relatively constant between 24 and 96 h. At 72 h, the number-average molar masses (M(n)) of PHA-glc/C and PHA-glc/S were 178,000 and 163,000 g/mol, respectively, which were also intermediate to the M(n) of PHA-glc (225,000 g/mol) and the respective PHA-TAG (PHA-C = 153,000 g/mol; PHA-S = 75,000 g/mol). These physical differences caused variations in the mechanical properties of mcl-PHA films, thus providing a new and effective method of modifying their properties.
Hoffecker, Brett M; Raffield, Laura M; Kamen, Diane L; Nowling, Tamara K
2013-01-01
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that disproportionately affects African American females. The causes of SLE are unknown but postulated to be a combination of genetic predisposition and environmental triggers. Vitamin D deficiency is one of the possible environmental triggers. In this study we evaluated relationships between vitamin D status, cellular aging (telomere length) and anti-telomere antibodies among African American Gullah women with SLE. The study population included African American female SLE patients and unaffected controls from the Sea Island region of South Carolina. Serum 25-hydroxyvitamin D levels were measured using a nonchromatographic radioimmunoassay. Telomere length was measured in genomic DNA of peripheral blood mononuclear cells (PBMCs) by monochrome multiplex quantitative PCR. Anti-telomere antibody levels were measured by enzyme-linked immunosorbent assay (ELISA). Patients with SLE had significantly shorter telomeres and higher anti-telomere antibody titers compared to age- and gender-matched unaffected controls. There was a positive correlation between anti-telomere antibody levels and disease activity among patients and a significant correlation of shorter telomeres with lower 25-hydroxyvitamin D levels in both patients and controls. In follow-up examination of a subset of the patients, the patients who remained vitamin D deficient tended to have shorter telomeres than those patients whose 25-hydroxyvitamin D levels were repleted. Increasing 25-hydroxyvitamin D levels in African American patients with SLE may be beneficial in maintaining telomere length and preventing cellular aging. Moreover, anti-telomere antibody levels may be a promising biomarker of SLE status and disease activity.
Brett M Hoffecker
Full Text Available Systemic lupus erythematosus (SLE is a chronic systemic autoimmune disease that disproportionately affects African American females. The causes of SLE are unknown but postulated to be a combination of genetic predisposition and environmental triggers. Vitamin D deficiency is one of the possible environmental triggers. In this study we evaluated relationships between vitamin D status, cellular aging (telomere length and anti-telomere antibodies among African American Gullah women with SLE. The study population included African American female SLE patients and unaffected controls from the Sea Island region of South Carolina. Serum 25-hydroxyvitamin D levels were measured using a nonchromatographic radioimmunoassay. Telomere length was measured in genomic DNA of peripheral blood mononuclear cells (PBMCs by monochrome multiplex quantitative PCR. Anti-telomere antibody levels were measured by enzyme-linked immunosorbent assay (ELISA. Patients with SLE had significantly shorter telomeres and higher anti-telomere antibody titers compared to age- and gender-matched unaffected controls. There was a positive correlation between anti-telomere antibody levels and disease activity among patients and a significant correlation of shorter telomeres with lower 25-hydroxyvitamin D levels in both patients and controls. In follow-up examination of a subset of the patients, the patients who remained vitamin D deficient tended to have shorter telomeres than those patients whose 25-hydroxyvitamin D levels were repleted. Increasing 25-hydroxyvitamin D levels in African American patients with SLE may be beneficial in maintaining telomere length and preventing cellular aging. Moreover, anti-telomere antibody levels may be a promising biomarker of SLE status and disease activity.
Aprile, Carmela; Corma, Avelino; Garcia, Hermenegildo
2008-02-14
This review summarizes the physical approaches towards enhancement of the photocatalytic activity of titanium dioxide by controlling this semiconductor in a certain length scale from subnanometric to submillimetric distances and provides examples in which the photocatalytic activity of TiO2 is not promoted by doping or changes in the chemical composition, but rather by application of physical concepts and spatial structuring of the semiconductor. Thus, encapsulation inside the micropores and cavities of zeolites (about 1 nm) renders small titanium oxide clusters with harnessed photocatalytic activity. On the other hand, nanometric titanium particles can be ordered forming structured periodic mesoporous materials with high specific surface area and well defined porosity. Titiania nanotubes of micrometric length, either independent or forming a membrane, also exhibit unique photocatalytic activity as consequence of the long diffusion length of charge carriers along the nanotube axis. Finally, photonic crystals with an inverse opal structure and the even more powerful concept of photonic sponges can serve to slow down visible light photons inside the material, increasing the effective optical path in such a way that light absorption near the absorption onset of the material is enhanced considerably. All these physical-based approaches have shown their potential in enhancing the photocatalytic activity of titania, paving the way for a new generation of novel structured photocatalysts in which physical and chemical concepts are combined.
Aspects of modelling and control of bioprocesses
Zhang, Xiachang
1995-12-31
The modelling and control of bioprocesses are the main subjects in this thesis. Different modelling approaches are proposed for different purposes in various bioprocesses. A conventional global model was constructed for a very complex mammalian cell culture process. A new concept of functional state and a multiple model (local models) approach were used for modelling the fed-batch baker`s yeast process for monitoring and control purposes. Finally, a combination of conventional electrical and biological models was used to simulate and to control a microbial fuel cell process. In the thesis, a yeast growth process was taken as an example to demonstrate the usefulness of the functional state concept and local models. The functional states were first defined according to the yeast metabolism. The process was then described by a set of simple local models. In different functional states, different local models were used. On the other hand, the on-line estimation of functional state and biomass of the process was discussed for process control purpose. As a consequence, both the functional state concept and the multiple model approach were applied for fuzzy logic control of yeast growth process. A fuzzy factor was calculated on the basis of a knowledge-based expert system and fuzzy logic rules. The factor was used to correct an ideal substrate feed rate. In the last part of the thesis, microbial fuel cell processes were studied. A microbial fuel cell is a device for direct conversion of chemical energy to electrical energy by using micro-organisms as catalysts. A combined model including conventional electrical and biological models was constructed for the process based on the biological and electrochemical phenomena
Quantum Internal Model Principle: Decoherence Control
Ganesan, Narayan; 10.1109/CDC.2007.4434706
2010-01-01
In this article, we study the problem of Decoherence Control for quantum systems by employing a novel construction termed "the bait" and with techniques from geometric control theory, in order to successfully and completely decouple an open quantum system from its environment. We re-formulate the problem of Decoherence Control as a disturbance rejection scheme which also leads us to the idea of Internal Model Principle for quantum control systems which is first of its kind in the literature. Classical internal model principle provides the guidelines for designing linear controllers for perfect tracking in the presence of external disturbances, with the help of the internal model of the disturbance generator. The theory of Disturbance Decoupling of the output from external noises is another problem that is well studied for classical systems. The two problems focus on different aspects viz. perfect output tracking and complete decoupling of output in the presence of the noise respectively. However for quantum s...
Mob control models of threshold collective behavior
Breer, Vladimir V; Rogatkin, Andrey D
2017-01-01
This book presents mathematical models of mob control with threshold (conformity) collective decision-making of the agents. Based on the results of analysis of the interconnection between the micro- and macromodels of active network structures, it considers the static (deterministic, stochastic and game-theoretic) and dynamic (discrete- and continuous-time) models of mob control, and highlights models of informational confrontation. Many of the results are applicable not only to mob control problems, but also to control problems arising in social groups, online social networks, etc. Aimed at researchers and practitioners, it is also a valuable resource for undergraduate and postgraduate students as well as doctoral candidates specializing in the field of collective behavior modeling.
A Course in... Model Predictive Control.
Arkun, Yaman; And Others
1988-01-01
Describes a graduate engineering course which specializes in model predictive control. Lists course outline and scope. Discusses some specific topics and teaching methods. Suggests final projects for the students. (MVL)
Hierarchical Model Predictive Control for Resource Distribution
Bendtsen, Jan Dimon; Trangbæk, K; Stoustrup, Jakob
2010-01-01
This paper deals with hierarchichal model predictive control (MPC) of distributed systems. A three level hierachical approach is proposed, consisting of a high level MPC controller, a second level of so-called aggregators, controlled by an online MPC-like algorithm, and a lower level of autonomous...... facilitates plug-and-play addition of subsystems without redesign of any controllers. The method is supported by a number of simulations featuring a three-level smart-grid power control system for a small isolated power grid....
Model Based Adaptive Piecewise Linear Controller for Complicated Control Systems
Tain-Sou Tsay
2014-01-01
Full Text Available A model based adaptive piecewise linear control scheme for industry processes with specifications on peak overshoots and rise times is proposed. It is a gain stabilized control technique. Large gain is used for large tracking error to get fast response. Small gain is used between large and small tracking error for good performance. Large gain is used again for small tracking error to cope with large disturbance. Parameters of the three-segment piecewise linear controller are found by an automatic regulating time series which is function of output characteristics of the plant and reference model. The time series will be converged to steady values after the time response of the considered system matching that of the reference model. The proposed control scheme is applied to four numerical examples which have been compensated by PID controllers. Parameters of PID controllers are found by optimization method. It gives an almost command independent response and gives significant improvements for response time and performance.
Model-based control of networked systems
Garcia, Eloy; Montestruque, Luis A
2014-01-01
This monograph introduces a class of networked control systems (NCS) called model-based networked control systems (MB-NCS) and presents various architectures and control strategies designed to improve the performance of NCS. The overall performance of NCS considers the appropriate use of network resources, particularly network bandwidth, in conjunction with the desired response of the system being controlled. The book begins with a detailed description of the basic MB-NCS architecture that provides stability conditions in terms of state feedback updates . It also covers typical problems in NCS such as network delays, network scheduling, and data quantization, as well as more general control problems such as output feedback control, nonlinear systems stabilization, and tracking control. Key features and topics include: Time-triggered and event-triggered feedback updates Stabilization of uncertain systems subject to time delays, quantization, and extended absence of feedback Optimal control analysis and ...
Chatterjee, Debmita; Bhattacharjee, Pritha; Sau, Tanmoy J; Das, Jayanta K; Sarma, Nilendu; Bandyopadhyay, Apurba K; Roy, Sib Sankar; Giri, Ashok K
2015-09-01
Arsenic (As) induces pre-malignant and malignant dermatological lesions, non-dermatological health effects and cancers in humans. Senescence involves telomere length changes and acquisition of senescence-associated secretory phenotype (SASP), which promotes carcinogenesis. Though in vitro studies have shown that As induces senescence, population based studies are lacking. We investigated the arsenic-induced senescence, telomere length alteration and its contribution towards development of As-induced skin cancer. The study participants included 60 each of As-exposed individuals with skin lesion (WSL), without skin lesions (WOSL) and 60 unexposed controls. Exposure assessment of drinking water and urine was done. SA β-gal activity, ELISA, and quantification of senescence proteins, alternative lengthening of telomere (ALT) associated proteins and telomerase activity were performed. Relative telomere length (RTL) was determined by qPCR. A significantly higher number of senescent cells, over-expression of p53 and p21 were observed in the As-exposed individuals when compared to unexposed. SASP markers, MMP-1/MMP-3 were significantly higher in the WSL but not IL-6/IL-8. A significant increase of RTL was observed in the WSL group, which was telomerase-independent but exhibited an over-expression of ALT associated proteins TRF-1 and TRF-2 with higher increase in TRF-2. An increased risk for developing As-induced skin lesions was found for individuals having RTL greater than 0.827 (odds ratio, 13.75; 95% CI: 5.66-33.41; P telomere length might be useful for predicting the risk of development of As-induced skin lesions.
Modelling and control of a flotation process
Ding, L.; Gustafsson, T. [Control Engineering Group, Lulea Univ. of Technology, Lulea (Sweden)
1999-07-01
A general description of a flotation process is given. The dynamic model of a MIMO nonlinear subprocess in flotation, i. e. the pulp levels in five compartments in series is developed and the model is verified with real data from a production plant. In order to reject constant disturbances five extra states are introduced and the model is modified. An exact linearization has been made for the non-linear model and a linear quadratic gaussian controller is proposed based on the linearized model. The simulation result shows an improved performance of the pulp level control when the set points are changed or a disturbance occur. In future the controller will be tested in production. (author)
Modeling and (adaptive) control of greenhouse climates
Udink ten Cate, A.J.
1983-01-01
The material presented in this thesis can be grouped around four themes, system concepts, modeling, control and adaptive control. In this summary these themes will be treated separately.
System concepts
In Chapters 1 and 2 an overview of the problem formulation
Modelling and (adaptive) control of greenhouse climates
Udink ten Cate, A.J.
1983-01-01
The material presented in this thesis can be grouped around four themes, system concepts, modeling, control and adaptive control. In this summary these themes will be treated separately.System conceptsIn Chapters 1 and 2 an overview of the problem formulation is presented. It is suggested that there
Martínez-Tossas, L. A. [Department of Mechanical Engineering, Johns Hopkins University, Baltimore 21218 MD USA; Churchfield, M. J. [National Renewable Energy Laboratory, Golden 80401 CO USA; Meneveau, C. [Department of Mechanical Engineering, Johns Hopkins University, Baltimore 21218 MD USA
2017-01-20
The actuator line model (ALM) is a commonly used method to represent lifting surfaces such as wind turbine blades within large-eddy simulations (LES). In the ALM, the lift and drag forces are replaced by an imposed body force that is typically smoothed over several grid points using a Gaussian kernel with some prescribed smoothing width e. To date, the choice of e has most often been based on numerical considerations related to the grid spacing used in LES. However, especially for finely resolved LES with grid spacings on the order of or smaller than the chord length of the blade, the best choice of e is not known. In this work, a theoretical approach is followed to determine the most suitable value of e, based on an analytical solution to the linearized inviscid flow response to a Gaussian force. We find that the optimal smoothing width eopt is on the order of 14%-25% of the chord length of the blade, and the center of force is located at about 13%-26% downstream of the leading edge of the blade for the cases considered. These optimal values do not depend on angle of attack and depend only weakly on the type of lifting surface. It is then shown that an even more realistic velocity field can be induced by a 2-D elliptical Gaussian lift-force kernel. Some results are also provided regarding drag force representation.
Model-Free Adaptive Heating Process Control
Ivana LUKÁČOVÁ; Piteľ, Ján
2009-01-01
The aim of this paper is to analyze the dynamic behaviour of a Model-Free Adaptive (MFA) heating process control. The MFA controller is designed as three layer neural network with proportional element. The method of backward propagation of errors was used for neural network training. Visualization and training of the artificial neural network was executed by Netlab in Matlab environment. Simulation of the MFA heating process control with outdoor temperature compensation has proved better resu...
Controllability, Observability, and Stability of Mathematical Models
Iggidr, Abderrahman
2004-01-01
International audience; This article presents an overview of three fundamental concepts in Mathematical System Theory: controllability, stability and observability. These properties play a prominent role in the study of mathematical models and in the understanding of their behavior. They constitute the main research subject in Control Theory. Historically the tools and techniques of Automatic Control have been developed for artificial engineering systems but nowadays they are more and more ap...
Development of Control Models and a Robust Multivariable Controller for Surface Shape Control
Winters, Scott Eric [Univ. of California, Davis, CA (United States)
2003-06-18
Surface shape control techniques are applied to many diverse disciplines, such as adaptive optics, noise control, aircraft flutter control and satellites, with an objective to achieve a desirable shape for an elastic body by the application of distributed control forces. Achieving the desirable shape is influenced by many factors, such as, actuator locations, sensor locations, surface precision and controller performance. Building prototypes to complete design optimizations or controller development can be costly or impractical. This shortfall, puts significant value in developing accurate modeling and control simulation approaches. This thesis focuses on the field of adaptive optics, although these developments have the potential for application in many other fields. A static finite element model is developed and validated using a large aperture interferometer system. This model is then integrated into a control model using a linear least squares algorithm and Shack-Hartmann sensor. The model is successfully exercised showing functionality for various wavefront aberrations. Utilizing a verified model shows significant value in simulating static surface shape control problems with quantifiable uncertainties. A new dynamic model for a seven actuator deformable mirror is presented and its accuracy is proven through experiment. Bond graph techniques are used to generate the state space model of the multi-actuator deformable mirror including piezo-electric actuator dynamics. Using this verified model, a robust multi-input multi-output (MIMO) H_{∞} controller is designed and implemented. This controller proved superior performance as compared to a standard proportional-integral controller (PI) design.
Jensen, Grethe Vestergaard; Shi, Qing; Deen, G. Roshan
2012-01-01
Structures of poly(ethylene propylene)–poly(ethylene oxide) (PEP–PEO) block copolymer micelles were determined from small-angle X-ray scattering and static light scattering and compared to predictions from a thermodynamic model. Both the corona block length and the solvent water–ethanol ratio were...
Wind farm models and control strategies
Sørensen, Poul Ejnar; Hansen, Anca Daniela; Iov, F.;
2005-01-01
models for a fixed speed wind turbine with active stall control and a variable speed wind turbine with doubly-fed induction generator. After that, the 3 wind farm concepts and control strategies are described.The 3 concepts are AC connected doubly fed turbines, AC connected active stall turbines and DC......This report describes models and control strategies for 3 different concepts of wind farms. Initially, the potential in improvement of grid integration, structural loads and energy production is investigated in a survey of opportunities. Then simulationmodels are described, including wind turbine...
Qi, Jin F; Jia, Cai H; Shin, Jung A; Woo, Jeong M; Wang, Xiang Y; Park, Jong T; Hong, Soon T; Lee, K-T
2016-02-01
In this study, a pH-stat digestion model and a simulated in vitro digestion model were employed to evaluate the digestion degree of lipids depending on different acylglycerols and acyl chain length (that is, diacylglycerol [DAG] compared with soybean oil representing long-chain triacylglycerol compared with medium-chain triacylglycerol [MCT]). In the pH-stat digestion model, differences were observed among the digestion degrees of 3 oils using digestion rate (k), digestion half-time (t1/2 ), and digestion extent (Φmax). The results showed the digestion rate order was MCT > soybean oil > DAG. Accordingly, the order of digestion half-times was MCT digestion model, digestion rates (k') and digestion half-times (t'1/2 ) were also obtained and the results showed a digestion rate order of MCT (k' = 0.068 min(-1) ) > soybean oil (k' = 0.037 min(-1) ) > DAG (k' = 0.024 min(-1) ). Consequently, the order of digestion half-times was MCT (t'1/2 = 10.20 min) digested faster than soybean oil, and that soybean oil was digested faster than DAG.
Switching Control System Based on Robust Model Reference Adaptive Control
HU Qiong; FEI Qing; MA Hongbin; WU Qinghe; GENG Qingbo
2016-01-01
For conventional adaptive control,time-varying parametric uncertainty and unmodeled dynamics are ticklish problems,which will lead to undesirable performance or even instability and nonrobust behavior,respectively.In this study,a class of discrete-time switched systems with unmodeled dynamics is taken into consideration.Moreover,nonlinear systems are here supposed to be approximated with the class of switched systems considered in this paper,and thereby switching control design is investigated for both switched systems and nonlinear systems to assure stability and performance.For robustness against unmodeled dynamics and uncertainty,robust model reference aclaptive control (RMRAC) law is developed as the basis of controller design for each individual subsystem in the switched systems or nonlinear systems.Meanwhile,two different switching laws are presented for switched systems and nonlinear systems,respectively.Thereby,the authors incorporate the corresponding switching law into the RMRAC law to construct two schemes of switching control respectively for the two kinds of controlled systems.Both closed-loop analyses and simulation examples are provided to illustrate the validity of the two proposed switching control schemes.Furthermore,as to the proposed scheme for nonlinear systems,its potential for practical application is demonstrated through simulations of longitudinal control for F-16 aircraft.
Fackler James C
2011-09-01
Full Text Available Abstract Background Children with viral respiratory infections who undergo general anesthesia are at increased risk of respiratory complications. We investigated the impact of RSV and influenza infection on perioperative outcomes in children undergoing general anesthesia. Methods We performed a retrospective case-control study. All patients under the age of 18 years who underwent general anesthesia at our institution with confirmed RSV or influenza infection diagnosed within 24 hours following induction between October 2002 and September 2008 were identified. Controls were randomly selected and were matched by surgical procedure, age, and time of year in a ratio of three controls per case. The primary outcome was postoperative length of stay (LOS. Results Twenty-four patients with laboratory-confirmed RSV or influenza who underwent general anesthesia prior to diagnosis of viral infection were identified and matched to 72 controls. Thirteen cases had RSV and 11 had influenza. The median postoperative LOS was three days (intra-quartile range 1 to 8 days for cases and two days (intra-quartile range 1 to 5 days for controls. Patients with influenza had a longer postoperative LOS (p Conclusions Our results suggest that children with evidence of influenza infection undergoing general anesthesia, even in the absence of symptoms previously thought to be associated with a high risk of complications, may have a longer postoperative hospital LOS when compared to matched controls. RSV and influenza infection was associated with an increased risk of unplanned PICU admission.
Distributed model predictive control made easy
Negenborn, Rudy
2014-01-01
The rapid evolution of computer science, communication, and information technology has enabled the application of control techniques to systems beyond the possibilities of control theory just a decade ago. Critical infrastructures such as electricity, water, traffic and intermodal transport networks are now in the scope of control engineers. The sheer size of such large-scale systems requires the adoption of advanced distributed control approaches. Distributed model predictive control (MPC) is one of the promising control methodologies for control of such systems. This book provides a state-of-the-art overview of distributed MPC approaches, while at the same time making clear directions of research that deserve more attention. The core and rationale of 35 approaches are carefully explained. Moreover, detailed step-by-step algorithmic descriptions of each approach are provided. These features make the book a comprehensive guide both for those seeking an introduction to distributed MPC as well as for those ...
Bayesian modeling of flexible cognitive control.
Jiang, Jiefeng; Heller, Katherine; Egner, Tobias
2014-10-01
"Cognitive control" describes endogenous guidance of behavior in situations where routine stimulus-response associations are suboptimal for achieving a desired goal. The computational and neural mechanisms underlying this capacity remain poorly understood. We examine recent advances stemming from the application of a Bayesian learner perspective that provides optimal prediction for control processes. In reviewing the application of Bayesian models to cognitive control, we note that an important limitation in current models is a lack of a plausible mechanism for the flexible adjustment of control over conflict levels changing at varying temporal scales. We then show that flexible cognitive control can be achieved by a Bayesian model with a volatility-driven learning mechanism that modulates dynamically the relative dependence on recent and remote experiences in its prediction of future control demand. We conclude that the emergent Bayesian perspective on computational mechanisms of cognitive control holds considerable promise, especially if future studies can identify neural substrates of the variables encoded by these models, and determine the nature (Bayesian or otherwise) of their neural implementation.
Intelligent Mechatronic Systems Modeling, Control and Diagnosis
Merzouki, Rochdi; Pathak, Pushparaj Mani; Ould Bouamama, Belkacem
2013-01-01
Acting as a support resource for practitioners and professionals looking to advance their understanding of complex mechatronic systems, Intelligent Mechatronic Systems explains their design and recent developments from first principles to practical applications. Detailed descriptions of the mathematical models of complex mechatronic systems, developed from fundamental physical relationships, are built on to develop innovative solutions with particular emphasis on physical model-based control strategies. Following a concurrent engineering approach, supported by industrial case studies, and drawing on the practical experience of the authors, Intelligent Mechatronic Systems covers range of topic and includes: • An explanation of a common graphical tool for integrated design and its uses from modeling and simulation to the control synthesis • Introductions to key concepts such as different means of achieving fault tolerance, robust overwhelming control and force and impedance control • Dedicated chapters ...
A Simple HCCI Engine Model for Control
Killingsworth, N; Aceves, S; Flowers, D; Krstic, M
2006-06-29
The homogeneous charge compression ignition (HCCI) engine is an attractive technology because of its high efficiency and low emissions. However, HCCI lacks a direct combustion trigger making control of combustion timing challenging, especially during transients. To aid in HCCI engine control we present a simple model of the HCCI combustion process valid over a range of intake pressures, intake temperatures, equivalence ratios, and engine speeds. The model provides an estimate of the combustion timing on a cycle-by-cycle basis. An ignition threshold, which is a function of the in-cylinder motored temperature and pressure is used to predict start of combustion. This model allows the synthesis of nonlinear control laws, which can be utilized for control of an HCCI engine during transients.
A comparison of model view controller and model view presenter
Qureshi, M. Rizwan Jameel; Sabir, Fatima
2014-01-01
Web application frameworks are managed by using different design strategies. Design strategies are applied by using different design processes. In each design process, requirement specifications are changed in to different design model that describe the detail of different data structure, system architecture, interface and components. Web application frame work is implemented by using Model View Controller (MVC) and Model View Presenter (MVP). These web application models are used to provide ...
Stochastic Control Model on Rent Seeking
无
2008-01-01
A continuous-time stochastic model is constructed to analyze how to control rent seeking behaviors. Using the stochastic optimization methods based on the modern risky theory, a unique positive solution to the dynamic model is derived. The effects of preference-related parameters on the optimal control level of rent seeking are discussed, and some policy measures are given. The results show that there exists a unique solution to the stochastic dynamic model under some macroeconomic assumptions, and that raising public expenditure may have reverse effects on rent seeking in an underdeveloped or developed economic environment.
NONLINEAR MODEL PREDICTIVE CONTROL OF CHEMICAL PROCESSES
R. G. SILVA
1999-03-01
Full Text Available A new algorithm for model predictive control is presented. The algorithm utilizes a simultaneous solution and optimization strategy to solve the model's differential equations. The equations are discretized by equidistant collocation, and along with the algebraic model equations are included as constraints in a nonlinear programming (NLP problem. This algorithm is compared with the algorithm that uses orthogonal collocation on finite elements. The equidistant collocation algorithm results in simpler equations, providing a decrease in computation time for the control moves. Simulation results are presented and show a satisfactory performance of this algorithm.
Control model for reconfigurable assembly systems
Yu Jianfeng; Yin Yuehong; Chen Zhaoneng
2005-01-01
This paper proposes knowledge based object-oriented timed colored Petri net, a modeling method for reconfigurable assembly systems. Combining knowledge and object-oriented method into timed colored Petri net, a comprehensive and powerful representation model for control of RAS is obtained. With object-oriented method the whole system can be decomposed into concrete objects explicitly, and their relationships are constructed according to the system assembly requirements. Finally, a simple assembly system modeled by the KTCOPN is presented.
Chaos control in traffic flow models
Shahverdiev, E M; Shahverdiev, Elman Mohammed; Tadaki, Shin-ichi
1998-01-01
Chaos control in some of the one- and two-dimensional traffic flow dynamical models in the mean field theory is studied.One dimensional model is investigated taking into account the effect of random delay. Two dimensional model takes into account the effects of overpasses, symmetric distribution of cars and blockages of cars moving in the same direction. Chaos synchronization is performed within both replica and nonreplica approaches, and using parameter perturbation method.
Zhou, Chao; Dhalle, Marc M.J.; ten Kate, Herman H.J.; Nijhuis, Arend
2014-01-01
The current transfer length of multi-filamentary superconducting NbTi and Nb3Sn strands was measured and analyzed. The aim is to understand and quantify the current distribution process between matrix and superconducting filaments occurring at current injection joints or shunting localized
Modeling Robot Flexibility for Endpoint Force Control.
1988-05-01
SIDM 19. KE9Y WORDS fCntknu. OnPVOO&O 0401 It 00041000111O ed 0000#uF 6P 1111411 amA.w) robot force control * robot control / robot dynamics flexible...no. 3, pp. 62-75. [2] Eppinger, S.D. and Seering, W.P. On Dynamic Models of Robot Force Control . In Proceedings of International Conference on...W.P. Understanding Bandwidth Limitations in Robot Force Control . In Proceedings of International Conference on Robotics and Automation. IEEE, April 1987
Explicit model predictive control accuracy analysis
Knyazev, Andrew; Zhu, Peizhen; Di Cairano, Stefano
2015-01-01
Model Predictive Control (MPC) can efficiently control constrained systems in real-time applications. MPC feedback law for a linear system with linear inequality constraints can be explicitly computed off-line, which results in an off-line partition of the state space into non-overlapped convex regions, with affine control laws associated to each region of the partition. An actual implementation of this explicit MPC in low cost micro-controllers requires the data to be "quantized", i.e. repre...
Modelling and simulations of controlled release fertilizer
Irfan, Sayed Ameenuddin; Razali, Radzuan; Shaari, Ku Zilati Ku; Mansor, Nurlidia
2016-11-01
The recent advancement in controlled release fertilizer has provided an alternative solution to the conventional urea, controlled release fertilizer has a good plant nutrient uptake they are environment friendly. To have an optimum plant intake of nutrients from controlled release fertilizer it is very essential to understand the release characteristics. A mathematical model is developed to predict the release characteristics from polymer coated granule. Numerical simulations are performed by varying the parameters radius of granule, soil water content and soil porosity to study their effect on fertilizer release. Understanding these parameters helps in the better design and improve the efficiency of controlled release fertilizer.
Panaite, Petrica-Adrian; Kuntzer, Thierry; Gourdon, Geneviève; Barakat-Walter, Ibtissam
2013-10-01
Myotonic dystrophy (DM1) is a multisystemic disease caused by an expansion of CTG repeats in the region of DMPK, the gene encoding DM protein kinase. The severity of muscle disability in DM1 correlates with the size of CTG expansion. As respiratory failure is one of the main causes of death in DM1, we investigated the correlation between respiratory impairment and size of the (CTG)n repeat in DM1 animal models. Using pressure plethysmography the respiratory function was assessed in control and transgenic mice carrying either 600 (DM600) or >1300 CTG repeats (DMSXL). The statistical analysis of respiratory parameters revealed that both DM1 transgenic mice sub-lines show respiratory impairment compared to control mice. In addition, there is no significant difference in breathing functions between the DM600 and DMSXL mice. In conclusion, these results indicate that respiratory impairment is present in both transgenic mice sub-lines, but the severity of respiratory failure is not related to the size of the (CTG)n expansion.
Control Rod Driveline Reactivity Feedback Model for Liquid Metal Reactors
Kwon, Young-Min; Jeong, Hae-Yong; Chang, Won-Pyo; Cho, Chung-Ho; Lee, Yong-Bum
2008-01-15
The thermal expansion of the control rod drivelines (CRDL) is one important passive mitigator under all unprotected accident conditions in the metal and oxide cores. When the CRDL are washed by hot sodium in the coolant outlet plenum, the CRDL thermally expands and causes the control rods to be inserted further down into the active core region, providing a negative reactivity feedback. Since the control rods are attached to the top of the vessel head and the core attaches to the bottom of the reactor vessel (RV), the expansion of the vessel wall as it heats will either lower the core or raise the control rods supports. This contrary thermal expansion of the reactor vessel wall pulls the control rods out of the core somewhat, providing a positive reactivity feedback. However this is not a safety factor early in a transient because its time constant is relatively large. The total elongated length is calculated by subtracting the vessel expansion from the CRDL expansion to determine the net control rod expansion into the core. The system-wide safety analysis code SSC-K includes the CRDL/RV reactivity feedback model in which control rod and vessel expansions are calculated using single-nod temperatures for the vessel and CRDL masses. The KALIMER design has the upper internal structures (UIS) in which the CRDLs are positioned outside the structure where they are exposed to the mixed sodium temperature exiting the core. A new method to determine the CRDL expansion is suggested. Two dimensional hot pool thermal hydraulic model (HP2D) originally developed for the analysis of the stratification phenomena in the hot pool is utilized for a detailed heat transfer between the CRDL mass and the hot pool coolant. However, the reactor vessel wall temperature is still calculated by a simple lumped model.
Bayesian modeling of flexible cognitive control
Jiang, Jiefeng; Heller, Katherine; Egner, Tobias
2014-01-01
“Cognitive control” describes endogenous guidance of behavior in situations where routine stimulus-response associations are suboptimal for achieving a desired goal. The computational and neural mechanisms underlying this capacity remain poorly understood. We examine recent advances stemming from the application of a Bayesian learner perspective that provides optimal prediction for control processes. In reviewing the application of Bayesian models to cognitive control, we note that an important limitation in current models is a lack of a plausible mechanism for the flexible adjustment of control over conflict levels changing at varying temporal scales. We then show that flexible cognitive control can be achieved by a Bayesian model with a volatility-driven learning mechanism that modulates dynamically the relative dependence on recent and remote experiences in its prediction of future control demand. We conclude that the emergent Bayesian perspective on computational mechanisms of cognitive control holds considerable promise, especially if future studies can identify neural substrates of the variables encoded by these models, and determine the nature (Bayesian or otherwise) of their neural implementation. PMID:24929218
Model Predictive Control based on Finite Impulse Response Models
Prasath, Guru; Jørgensen, John Bagterp
2008-01-01
We develop a regularized l2 finite impulse response (FIR) predictive controller with input and input-rate constraints. Feedback is based on a simple constant output disturbance filter. The performance of the predictive controller in the face of plant-model mismatch is investigated by simulations...
Model Predictive Control of Wind Turbines
Henriksen, Lars Christian
the need for maintenance of the wind turbine. Either way, better total-cost-of-ownership for wind turbine operators can be achieved by improved control of the wind turbines. Wind turbine control can be improved in two ways, by improving the model on which the controller bases its design or by improving......Wind turbines play a major role in the transformation from a fossil fuel based energy production to a more sustainable production of energy. Total-cost-of-ownership is an important parameter when investors decide in which energy technology they should place their capital. Modern wind turbines...... are controlled by pitching the blades and by controlling the electro-magnetic torque of the generator, thus slowing the rotation of the blades. Improved control of wind turbines, leading to reduced fatigue loads, can be exploited by using less materials in the construction of the wind turbine or by reducing...
Kasai, Chika; Sugimoto, Kazushi; Moritani, Isao; Tanaka, Junichiro; Oya, Yumi; Inoue, Hidekazu; Tameda, Masahiko; Shiraki, Katsuya; Ito, Masaaki; Takei, Yoshiyuki; Takase, Kojiro
2016-01-01
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in Japan. The etiology of CRC has been linked to numerous factors including genetic mutation, diet, life style, inflammation, and recently, the gut microbiota. However, CRC-associated gut microbiota is still largely unexamined. This study used terminal restriction fragment length polymorphism (T-RFLP) and next-generation sequencing (NGS) to analyze and compare gut microbiota of Japanese control subjects and Japanese patients with carcinoma in adenoma. Stool samples were collected from 49 control subjects, 50 patients with colon adenoma, and 9 patients with colorectal cancer (3/9 with invasive cancer and 6/9 with carcinoma in adenoma) immediately before colonoscopy; DNA was extracted from each stool sample. Based on T-RFLP analysis, 12 subjects (six control and six carcinoma in adenoma subjects) were selected; their samples were used for NGS and species-level analysis. T-RFLP analysis showed no significant differences in bacterial population between control, adenoma and cancer groups. However, NGS revealed that i), control and carcinoma in adenoma subjects had different gut microbiota compositions, ii), one bacterial genus (Slackia) was significantly associated with the control group and four bacterial genera (Actinomyces, Atopobium, Fusobacterium, and Haemophilus) were significantly associated with the carcinoma-in-adenoma group, and iii), several bacterial species were significantly associated with each type (control: Eubacterium coprostanoligens; carcinoma in adenoma: Actinomyces odontolyticus, Bacteroides fragiles, Clostridium nexile, Fusobacterium varium, Haemophilus parainfluenzae, Prevotella stercorea, Streptococcus gordonii, and Veillonella dispar). Gut microbial properties differ between control subjects and carcinoma-in-adenoma patients in this Japanese population, suggesting that gut microbiota is related to CRC prevention and development.
Thanassekos, Stéphane; Robert, Dominique; Fortier, Louis
2012-05-01
A bioenergetics individual based model (IBM) of early growth is used to investigate the relative importance of length-dependent and growth-dependent mortality during the early life (0-45 d) of Arctic cod in the Northeast Water (NEW) in 1993 and the North Water (NOW) in 1998. In the model, individual growth is forced by the observed temperature and prey concentration histories as prescribed by the hatch date of a larva. The IBM reproduced well the observed length-at-age and revealed large ontogenetic and interregional fluctuations in instantaneous growth. Four mortality scenarios were compared for each population: (1) constant mortality (estimated from catch-at-age data); (2) length-dependent mortality; (3) growth-dependent mortality; and (4) combined length- and growth-dependent mortality. Scenarios 2, 3, and 4 were parameterized to achieve the final survival produced by the constant mortality rates estimated from observations (scenario 1). Scenario 2 accounted well for declining mortality with size but not for the large variations in growth-dependent mortality. Scenario 3 failed to capture the decreasing vulnerability of surviving larvae to predation. Only scenario 4 accounted for both the large fluctuations in growth-dependent mortality and the progressive shift in dominance from length-dependent to growth-dependent mortality as the survivors increased in size. Sub-sampling the model output to reproduce the limited temporal resolution of sampling at sea improved the fit between observed and modeled frequencies-at-age, and pointed to the under-sampling of the smallest larvae as a major sampling bias.
Optimal control application to an Ebola model
Ebenezer Bonyah; Kingsley Badu; Samuel Kwesi Asiedu-Addo
2016-01-01
Ebola virus is a severe,frequently fatal illness,with a case fatality rate up to 90%.The outbreak of the disease has been acknowledged by World Health Organization as Public Health Emergency of International Concern.The threat of Ebola in West Africa is still a major setback to the socioeconomic development.Optimal control theory is applied to a system of ordinary differential equations which is modeling Ebola infection through three different routes including contact between humans and a dead body.In an attempt to reduce infection in susceptible population,a preventive control is put in the form of education and campaign and two treatment controls are applied to infected and late-stage infected(super) human population.The Pontryagins maximum principle is employed to characterize optimality control,which is then solved numerically.It is observed that time optimal control is existed in the model.The activation of each control showed a positive reduction of infection.The overall effect of activation of all the controls simultaneously reduced the effort required for the reduction of the infection quickly.The obtained results present a good framework for planning and designing cost-effective strategies for good interventions in dealing with Ebola disease.It is established that in order to reduce Ebola threat all the three controls must be taken into consideration concurrently.
The Very Best of the Millennium: Longitudinal Research and the Demand-Control-(Support) Model
Lange, A.H.de; Taris, T.W.; Kompier, M.A.J.; Houtman, I.L.D.; Bongers, P.M.
2003-01-01
This study addressed the methodological quality of longitudinal research examining R. Karasek and T. Theorell's (1990) demand-control-(support) model and reviewed the results of the best of this research. Five criteria for evaluating methodological quality were used: type of design, length of time l
El-Gezawy, Hani; Rettig, Wolfgang
2006-09-01
The photophysical behaviour of a series of donor-acceptor-polyenes of different length: 4-dimethylamino-4'-cyanostilbene (DCS), 4-dimethylamino-4'-cyano-1,4-diphenylbutadiene (DCB) and 4-dimethylamino-4'-cyano-1,4-diphenylhexatriene (DCH) has been studied by means of steady state and time resolved fluorescence and low temperature measurements. Quantum chemical calculations were performed for comparison. For all three dyes, the fluorescence quantum yields show a maximum in the most polar solvents. A pronounced solvatochromic behaviour is only observed for the emission spectra whereas the absorption spectra remain nearly unaffected. The nonradiative decay decreases in the order DCS > DCB > DCH. Similarly, the radiative rate constant decreases in this order, contrary to the usual behaviour for a lengthening of the π-system. The chain-length dependence of the dipole moments of the relaxed excited state μe is better described by the Onsager radius derived from molecular length rather than from the density approach. Both calculations and experiments support the conclusion that the emissive state is not a TICT state.
Botteaux, Anne; Sani, Musa; Kayath, Christian A.; Boekema, Egbert J.; Allaoui, Abdelmounaaim; Allaoui, Abdelmounaaïm
2008-01-01
The effectors of enterocyte invasion by Shigella are dependent on a type III secretion system that contains a needle whose length average does not exceed 50 nm. Previously, we reported that Spa32 is required for needle length control as well as to switch substrate specificity from MxiH to Ipa
Mathematical modelling of leprosy and its control.
Blok, David J; de Vlas, Sake J; Fischer, Egil A J; Richardus, Jan Hendrik
2015-03-01
Leprosy or Hansen's disease is an infectious disease caused by the bacterium Mycobacterium leprae. The annual number of new leprosy cases registered worldwide has remained stable over the past years at over 200,000. Early case finding and multidrug therapy have not been able interrupt transmission completely. Elimination requires innovation in control and sustained commitment. Mathematical models can be used to predict the course of leprosy incidence and the effect of intervention strategies. Two compartmental models and one individual-based model have been described in the literature. Both compartmental models investigate the course of leprosy in populations and the long-term impact of control strategies. The individual-based model focusses on transmission within households and the impact of case finding among contacts of new leprosy patients. Major improvement of these models should result from a better understanding of individual differences in exposure to infection and developing leprosy after exposure. Most relevant are contact heterogeneity, heterogeneity in susceptibility and spatial heterogeneity. Furthermore, the existing models have only been applied to a limited number of countries. Parameterization of the models for other areas, in particular those with high incidence, is essential to support current initiatives for the global elimination of leprosy. Many challenges remain in understanding and dealing with leprosy. The support of mathematical models for understanding leprosy epidemiology and supporting policy decision making remains vital.
Modeling and Control of Large Flexible Structures.
1984-07-31
systems with hybrid (lumped and distributed) structure. * -3.Development of stabilizing control strategies for nonlinear distributed models, including...process, but much more needs to be done. el .It ;,, "..- ,. ,-,,o’,, .4. : ") Part I: :i: ’i" ’" Wierner-Hopf Methods for Design of Stabilizing ... Control Systems :: Z’" ..-- -~ . . . . .. . . . . . . ... . . . . .......- ~ .. . . S 5 * * .5 .. ** .*% - * 5*55 * . . . . % % ’ * . ’ % , . :.:. -A
Plant Modeling for Human Supervisory Control
Lind, Morten
1999-01-01
This paper provides an overview of multilevel flow modelling (MFM) and its application for design of displays for the supervisory control of industrial plant. The problem of designing the inforrrzatian content of sacpervisory displays is discussed and plant representations like MFM using levels...... is also provided by an analysis of the relations between levels of abstraction. It is also described how MFM supparts reazsonin about control actions by defining levels of intervention and by modal distinctions between function enablement and initiation....
Modelling Driver Assitance Systems by Optimal Control
Wang, M.; Daamen, W.; Hoogendoorn, S.P.; Van Arem, B.
2012-01-01
Driver assistance systems support drivers in operating vehicles in a safe, comfortable and efficient way, and thus may induce changes in traffic flow characteristics. This paper put forward a receding horizon control framework to model driver assistance systems. The accelerations of automated vehicles are determined to optimise a cost function, assuming other vehicles driving at stationary conditions over a prediction horizon. The flexibility of the framework is demonstrated with controller d...
Insecticide control in a Dengue epidemics model
Rodrigues, Helena Sofia; Torres, Delfim F M
2010-01-01
A model for the transmission of dengue disease is presented. It consists of eight mutually-exclusive compartments representing the human and vector dynamics. It also includes a control parameter (insecticide) in order to fight the mosquitoes. The main goal of this work is to investigate the best way to apply the control in order to effectively reduce the number of infected humans and mosquitoes. A case study, using data of the outbreak that occurred in 2009 in Cape Verde, is presented.
Abdul Wahid
2016-02-01
Full Text Available Distillation columns are widely used in chemical industry as unit operation and required advance process control because it has multi input multi output (MIMO or multi-variable system, which is hard to be controlled. Model predictive control (MPC is one of alternative controller developed for MIMO system due to loops interaction to be controlled. This study aimed to obtain dynamic model of process control on a distillation column using MPC, and to get the optimum performance of MPC controller. Process control in distillation columns performed by simulating the dynamic models of distillation columns by UNISIM R390.1 software. The optimization process was carried out by tuning the MPC controller parameters such as sampling time (Ts = 1 – 240 s, prediction horizon (P = 1-400, and the control horizon (M=1-400. The comparison between the performance of MPC and PI controller is presented and Integral Absolut Error (IAE was used as comparison parameter. The results indicate that the performance of MPC was better than PI controller for set point change 0.95 to 0.94 on distillate product composition using a modified model 1 with IAE 0.0584 for MPC controller and 0.0782 for PI controller.
Modelling and control of dynamic systems using gaussian process models
Kocijan, Juš
2016-01-01
This monograph opens up new horizons for engineers and researchers in academia and in industry dealing with or interested in new developments in the field of system identification and control. It emphasizes guidelines for working solutions and practical advice for their implementation rather than the theoretical background of Gaussian process (GP) models. The book demonstrates the potential of this recent development in probabilistic machine-learning methods and gives the reader an intuitive understanding of the topic. The current state of the art is treated along with possible future directions for research. Systems control design relies on mathematical models and these may be developed from measurement data. This process of system identification, when based on GP models, can play an integral part of control design in data-based control and its description as such is an essential aspect of the text. The background of GP regression is introduced first with system identification and incorporation of prior know...
Model Predictive Control of Sewer Networks
Pedersen, Einar B.; Herbertsson, Hannes R.; Niemann, Henrik;
2016-01-01
The developments in solutions for management of urban drainage are of vital importance, as the amount of sewer water from urban areas continues to increase due to the increase of the world’s population and the change in the climate conditions. How a sewer network is structured, monitored...... and controlled have thus become essential factors for efficient performance of waste water treatment plants. This paper examines methods for simplified modelling and controlling a sewer network. A practical approach to the problem is used by analysing simplified design model, which is based on the Barcelona...
Stochastic Optimal Control Models for Online Stores
Bradonjić, Milan
2011-01-01
We present a model for the optimal design of an online auction/store by a seller. The framework we use is a stochastic optimal control problem. In our setting, the seller wishes to maximize her average wealth level, where she can control her price per unit via her reputation level. The corresponding Hamilton-Jacobi-Bellmann equation is analyzed for an introductory case. We then turn to an empirically justified model, and present introductory analysis. In both cases, {\\em pulsing} advertising strategies are recovered for resource allocation. Further numerical and functional analysis will appear shortly.
Model Based Control of Reefer Container Systems
Sørensen, Kresten Kjær
This thesis is concerned with the development of model based control for the Star Cool refrigerated container (reefer) with the objective of reducing energy consumption. This project has been carried out under the Danish Industrial PhD programme and has been financed by Lodam together with the Da......This thesis is concerned with the development of model based control for the Star Cool refrigerated container (reefer) with the objective of reducing energy consumption. This project has been carried out under the Danish Industrial PhD programme and has been financed by Lodam together...
You, Weilong; Pei, Binbin; Sun, Ke; Zhang, Lei; Yang, Heng; Li, Xinxin
2017-10-01
This paper presents an oven controlled N++ [1 0 0] length-extensional mode silicon resonator, with a lookup-table based control algorithm. The temperature coefficient of resonant frequency (TCF) of the N++ doped resonator is nonlinear, and there is a turnover temperature point at which the TCF is equal to zero. The resonator is maintained at the turnover point by Joule heating; this temperature is a little higher than the upper limit of the industrial temperature range. It is demonstrated that the control algorithm based on the thermoresistor on the substrate and the lookup table for heating voltage versus chip temperature is sufficiently accurate to achieve a frequency stability of ±0.5 ppm over the industrial temperature range. Because only two leads are required for electrical heating and piezoresistive sensing, the power required for heating of this resonator can be potentially lower than that of the oscillators with closed-loop oven control algorithm. It is also shown that the phase noise can be suppressed at the turnover temperature because of the very low value of the TCF, which justifies the usage of the heating voltage as the excitation voltage of the Wheatstone half-bridge.
V. Balaji
2016-12-01
Full Text Available pH control plays a important role in any chemical plant and process industries. For the past four decades the classical PID controller has been occupied by the industries. Due to the faster computing technology in the industry demands a tighter advanced control strategy. To fulfill the needs and requirements Model Predictive Control (MPC is the best among all the advanced control algorithms available in the present scenario. The study and analysis has been done for First Order plus Delay Time (FOPDT model controlled by Proportional Integral Derivative (PID and MPC using the Matlab software. This paper explores the capability of the MPC strategy, analyze and compare the control effects with conventional control strategy in pH control. A comparison results between the PID and MPC is plotted using the software. The results clearly show that MPC provide better performance than the classical controller.
Baer-Riedhart, Jennifer L.; Landy, Robert J.
1987-01-01
The highly integrated digital electronic control (HIDEC) program at NASA Ames Research Center, Dryden Flight Research Facility is a multiphase flight research program to quantify the benefits of promising integrated control systems. McDonnell Aircraft Company is the prime contractor, with United Technologies Pratt and Whitney Aircraft, and Lear Siegler Incorporated as major subcontractors. The NASA F-15A testbed aircraft was modified by the HIDEC program by installing a digital electronic flight control system (DEFCS) and replacing the standard F100 (Arab 3) engines with F100 engine model derivative (EMD) engines equipped with digital electronic engine controls (DEEC), and integrating the DEEC's and DEFCS. The modified aircraft provides the capability for testing many integrated control modes involving the flight controls, engine controls, and inlet controls. This paper focuses on the first two phases of the HIDEC program, which are the digital flight control system/aircraft model identification (DEFCS/AMI) phase and the adaptive engine control system (ADECS) phase.
Cong, Haoxi; Li, Qingmin; Xing, Jinyuan; Li, Jinsong; Chen, Qiang
2015-06-01
The prompt extinction of the secondary arc is critical to the single-phase reclosing of AC transmission lines, including half-wavelength power transmission lines. In this paper, a low-voltage physical experimental platform was established and the motion process of the secondary arc was recorded by a high-speed camera. It was found that the arcing time of the secondary arc rendered a close relationship with its arc length. Through the input and output power energy analysis of the secondary arc, a new critical length criterion for the arcing time was proposed. The arc chain model was then adopted to calculate the arcing time with both the traditional and the proposed critical length criteria, and the simulation results were compared with the experimental data. The study showed that the arcing time calculated from the new critical length criterion gave more accurate results, which can provide a reliable criterion in term of arcing time for modeling and simulation of the secondary arc related with power transmission lines. supported by National Natural Science Foundation of China (Nos. 51277061 and 51420105011)
Atom-Role-Based Access Control Model
Cai, Weihong; Huang, Richeng; Hou, Xiaoli; Wei, Gang; Xiao, Shui; Chen, Yindong
Role-based access control (RBAC) model has been widely recognized as an efficient access control model and becomes a hot research topic of information security at present. However, in the large-scale enterprise application environments, the traditional RBAC model based on the role hierarchy has the following deficiencies: Firstly, it is unable to reflect the role relationships in complicated cases effectively, which does not accord with practical applications. Secondly, the senior role unconditionally inherits all permissions of the junior role, thus if a user is under the supervisor role, he may accumulate all permissions, and this easily causes the abuse of permission and violates the least privilege principle, which is one of the main security principles. To deal with these problems, we, after analyzing permission types and role relationships, proposed the concept of atom role and built an atom-role-based access control model, called ATRBAC, by dividing the permission set of each regular role based on inheritance path relationships. Through the application-specific analysis, this model can well meet the access control requirements.
Modelling and Control of the Wavestar Prototype
Hansen, Rico Hjerm; Kramer, Morten M.
2011-01-01
In the field of wave energy it is well known that control of point absorbers is essential in order to increase energy capture from waves. Correspondingly, advanced control is an integrated part of the Wavestar design. This paper presents the control method, referred to as the Wave Power Extraction...... Algorithm (WPEA), applied to the full-scale Wavestar Prototype for maximizing energy extraction. The WPEA is optimized based on simulations of the point absorbers in different sea states. Hence, a presentation of a hydrodynamic model of the Wavestar is included in the paper. A simplified Power Take-Off (PTO...
Model based control of refrigeration systems
Sloth Larsen, L.F.
2005-11-15
The subject for this Ph.D. thesis is model based control of refrigeration systems. Model based control covers a variety of different types of controls, that incorporates mathematical models. In this thesis the main subject therefore has been restricted to deal with system optimizing control. The optimizing control is divided into two layers, where the system oriented top layers deals with set-point optimizing control and the lower layer deals with dynamical optimizing control in the subsystems. The thesis has two main contributions, i.e. a novel approach for set-point optimization and a novel approach for desynchronization based on dynamical optimization. The focus in the development of the proposed set-point optimizing control has been on deriving a simple and general method, that with ease can be applied on various compositions of the same class of systems, such as refrigeration systems. The method is based on a set of parameter depended static equations describing the considered process. By adapting the parameters to the given process, predict the steady state and computing a steady state gradient of the cost function, the process can be driven continuously towards zero gradient, i.e. the optimum (if the cost function is convex). The method furthermore deals with system constrains by introducing barrier functions, hereby the best possible performance taking the given constrains in to account can be obtained, e.g. under extreme operational conditions. The proposed method has been applied on a test refrigeration system, placed at Aalborg University, for minimization of the energy consumption. Here it was proved that by using general static parameter depended system equations it was possible drive the set-points close to the optimum and thus reduce the power consumption with up to 20%. In the dynamical optimizing layer the idea is to optimize the operation of the subsystem or the groupings of subsystems, that limits the obtainable system performance. In systems
Herrera Antonio
2010-06-01
Full Text Available Abstract Background Primary stability of the graft is essential in anterior cruciate ligament surgery. An optimal method of fixation should be easy to insert and provide great resistance against pull-out forces. A controlled laboratory study was designed to test the primary stability of ACL tendinous grafts in the tibial tunnel. The correlation between resistance to traction forces and the cross-section and length of the screw was studied. Methods The tibial phase of ACL reconstruction was performed in forty porcine tibias using digital flexor tendons of the same animal. An 8 mm tunnel was drilled in each specimen and two looped tendons placed as graft. Specimens were divided in five groups according to the diameter and length of the screw used for fixation. Wedge interference screws were used. Longitudinal traction was applied to the graft with a Servohydraulic Fatigue System. Load and displacement were controlled and analyzed. Results The mean loads to failure for each group were 295,44 N (Group 1; 9 × 23 screw, 564,05 N (Group 2; 9 × 28, 614,95 N (Group 3; 9 × 35, 651,14 N (Group 4; 10 × 28 and 664,99 (Group 5; 10 × 35. No slippage of the graft was observed in groups 3, 4 and 5. There were significant differences in the load to failure among groups (ANOVA/P Conclusions Longer and wider interference screws provide better fixation in tibial ACL graft fixation. Short screws (23 mm do not achieve optimal fixation and should be implanted only with special requirements.
Modelling and control of growing slugs in horizontal multiphase pipe flows
Steinar M. Elgsæter
2006-07-01
Full Text Available In this paper, the use of active control to restrict the length of growing slugs in horizontal pipelines is investigated. Specifically, the paper attempts to determine if such control can be attained with realistic measurements and actuators. Simulations in OLGA2000 show that a feedback controller can use measurements or estimates of slug length to control the growth of a slug in a horizontal pipeline by partially closing inlet or outlet chokes. A control-volume approach is used to develop a low-order model of inlet choke-slug growth dynamics based on mass- and impulse balances. The resulting model is a system of nonlinear differential-algebraic equations, which is suitable for observer-design. The tuned model is found to be in good agreement with experiments and OLGA2000-simulations. Linearizations of the model are found to be observable around realistic trajectories when rates and pressures at the inlet and outlet are measured. An extended Luenberger-observer is shown to give good estimates of slug length and -position in simulations even under model uncertainty.
Standard controlled vocabulary for climate models
Moine, Marie-Pierre; Pascoe, Charlotte; Guilyardi, Eric; Ford, Rupert
2010-05-01
The scope of climate modeling has grown tremendously in the last 10 years, resulting in a large variety of climate models, increasing complexity with more physical or chemical components and huge volumes of data sets (simulation outputs). While significant efforts to standardise the associated metadata (i.e. data describing data and models) have already been made in recent projects (e.g. CF standard names for CMIP3), detailed standards documentation of the models and experiments that created this data is still lacking. The EU METAFOR Project (http://metaforclimate.eu) is specifically addressing this issue by creating new metadata schemas in cooperation with existing standards in Earth System Modeling (Curator, GridSpec, CF convention, NumSim, etc.). Descriptions of climate simulations, of the data they produce, and of the numerical models used to perform these simulations are all within the scope of METAFOR and these descriptions are assembled in a common information model (the CIM). Of particular note is the metadata for numerical models that is found in the CIM. This paper presents the controlled vocabulary (CV) that has been collected by METAFOR to describe (in a common manner) the components of the numerical models developed by the different modeling centres. This vocabulary is used in the model part of the web-based questionnaire that METAFOR has developed in support of the upcoming IPCC exercise (the CMIP5 questionnaire). The methods to (1) establish standards for this vocabulary via interactions with climate scientists, (2) utilise the vocabulary in the web-based questionnaire and (3) process the vocabulary for ingestion in the Earth System Grid (ESG) portal, are described. Governance aspects of this new controlled vocabulary are also addressed.
Unreachable Setpoints in Model Predictive Control
Rawlings, James B.; Bonné, Dennis; Jørgensen, John Bagterp
2008-01-01
steady state is established for terminal constraint model predictive control (MPC). The region of attraction is the steerable set. Existing analysis methods for closed-loop properties of MPC are not applicable to this new formulation, and a new analysis method is developed. It is shown how to extend...
Bicycle Rider Control: Observations, Modeling & Experiments
Kooijman, J.D.G.
2012-01-01
Bicycle designers traditionally develop bicycles based on experience and trial and error. Adopting modern engineering tools to model bicycle and rider dynamics and control is another method for developing bicycles. This method has the potential to evaluate the complete design space, and thereby dev
Modeling and control of antennas and telescopes
Gawronski, Wodek
2008-01-01
The book shows, step-by-step, the design, implementation, and testing of the antenna/telescope control system, from the design stage (analytical model) to fine tuning of the RF beam pointing (monopulse and conscan). It includes wide use of Matlab and Simulink..
Power system stability modelling, analysis and control
Sallam, Abdelhay A
2015-01-01
This book provides a comprehensive treatment of the subject from both a physical and mathematical perspective and covers a range of topics including modelling, computation of load flow in the transmission grid, stability analysis under both steady-state and disturbed conditions, and appropriate controls to enhance stability.
Distributed Model Predictive Control via Dual Decomposition
Biegel, Benjamin; Stoustrup, Jakob; Andersen, Palle
2014-01-01
This chapter presents dual decomposition as a means to coordinate a number of subsystems coupled by state and input constraints. Each subsystem is equipped with a local model predictive controller while a centralized entity manages the subsystems via prices associated with the coupling constraints...
Control Architecture Modeling for Future Power Systems
Heussen, Kai
and operation structures; and finally the application to some concrete study cases, including a present system balancing, and proposed control structures such as Microgrids and Cells. In the second part, the main contributions are the outline of a formation strategy, integrating the design and model...
Modeling the Aneuploidy Control of Cancer
Wang Zhong
2010-07-01
Full Text Available Abstract Background Aneuploidy has long been recognized to be associated with cancer. A growing body of evidence suggests that tumorigenesis, the formation of new tumors, can be attributed to some extent to errors occurring at the mitotic checkpoint, a major cell cycle control mechanism that acts to prevent chromosome missegregation. However, so far no statistical model has been available quantify the role aneuploidy plays in determining cancer. Methods We develop a statistical model for testing the association between aneuploidy loci and cancer risk in a genome-wide association study. The model incorporates quantitative genetic principles into a mixture-model framework in which various genetic effects, including additive, dominant, imprinting, and their interactions, are estimated by implementing the EM algorithm. Results Under the new model, a series of hypotheses tests are formulated to explain the pattern of the genetic control of cancer through aneuploid loci. Simulation studies were performed to investigate the statistical behavior of the model. Conclusions The model will provide a tool for estimating the effects of genetic loci on aneuploidy abnormality in genome-wide studies of cancer cells.
Nonlinear model predictive control theory and algorithms
Grüne, Lars
2017-01-01
This book offers readers a thorough and rigorous introduction to nonlinear model predictive control (NMPC) for discrete-time and sampled-data systems. NMPC schemes with and without stabilizing terminal constraints are detailed, and intuitive examples illustrate the performance of different NMPC variants. NMPC is interpreted as an approximation of infinite-horizon optimal control so that important properties like closed-loop stability, inverse optimality and suboptimality can be derived in a uniform manner. These results are complemented by discussions of feasibility and robustness. An introduction to nonlinear optimal control algorithms yields essential insights into how the nonlinear optimization routine—the core of any nonlinear model predictive controller—works. Accompanying software in MATLAB® and C++ (downloadable from extras.springer.com/), together with an explanatory appendix in the book itself, enables readers to perform computer experiments exploring the possibilities and limitations of NMPC. T...
Computer Modelling and Simulation for Inventory Control
G.K. Adegoke
2012-07-01
Full Text Available This study concerns the role of computer simulation as a device for conducting scientific experiments on inventory control. The stores function utilizes a bulk of physical assets and engages a bulk of financial resources in a manufacturing outfit therefore there is a need for an efficient inventory control. The reason being that inventory control reduces cost of production and thereby facilitates the effective and efficient accomplishment of production objectives of an organization. Some mathematical and statistical models were used to compute the Economic Order Quantity (EOQ. Test data were gotten from a manufacturing company and same were simulated. The results generated were used to predict a real life situation and have been presented and discussed. The language of implementation for the three models is Turbo Pascal due to its capability, generality and flexibility as a scientific programming language.
Hybrid adaptive control of a dragonfly model
Couceiro, Micael S.; Ferreira, Nuno M. F.; Machado, J. A. Tenreiro
2012-02-01
Dragonflies show unique and superior flight performances than most of other insect species and birds. They are equipped with two pairs of independently controlled wings granting an unmatchable flying performance and robustness. In this paper, it is presented an adaptive scheme controlling a nonlinear model inspired in a dragonfly-like robot. It is proposed a hybrid adaptive ( HA) law for adjusting the parameters analyzing the tracking error. At the current stage of the project it is considered essential the development of computational simulation models based in the dynamics to test whether strategies or algorithms of control, parts of the system (such as different wing configurations, tail) as well as the complete system. The performance analysis proves the superiority of the HA law over the direct adaptive ( DA) method in terms of faster and improved tracking and parameter convergence.
Nonsmooth mechanics models, dynamics and control
Brogliato, Bernard
2016-01-01
Now in its third edition, this standard reference is a comprehensive treatment of nonsmooth mechanical systems refocused to give more prominence to control and modelling. It covers Lagrangian and Newton–Euler systems, detailing mathematical tools such as convex analysis and complementarity theory. The ways in which nonsmooth mechanics influence and are influenced by well-posedness analysis, numerical analysis and simulation, modelling and control are explained. Contact/impact laws, stability theory and trajectory-tracking control are given in-depth exposition connected by a framework formed from complementarity systems and measure-differential inclusions. Links are established with electrical circuits with set-valued nonsmooth elements and with other nonsmooth dynamical systems like impulsive and piecewise linear systems. Nonsmooth Mechanics (third edition) has been substantially rewritten, edited and updated to account for the significant body of results that have emerged in the twenty-first century—incl...
Modelling and Control of the Wavestar Prototype
Hansen, Rico Hjerm; Kramer, Morten M.
2011-01-01
Algorithm (WPEA), applied to the full-scale Wavestar Prototype for maximizing energy extraction. The WPEA is optimized based on simulations of the point absorbers in different sea states. Hence, a presentation of a hydrodynamic model of the Wavestar is included in the paper. A simplified Power Take-Off (PTO......In the field of wave energy it is well known that control of point absorbers is essential in order to increase energy capture from waves. Correspondingly, advanced control is an integrated part of the Wavestar design. This paper presents the control method, referred to as the Wave Power Extraction......) is also added to the model, enabling the optimization of the WPEA to take into account the PTO constraints of PTO bandwidth and force limitations. The predicted results of the optimized WPEA are compared to real measurements from theWavestar Prototype, showing good compliance....
Hua Wong
Full Text Available In the nucleus of eukaryotic cells, histone proteins organize the linear genome into a functional and hierarchical architecture. In this paper, we use the crystal structures of the nucleosome core particle, B-DNA and the globular domain of H5 linker histone to build the first all-atom model of compact chromatin fibers. In this 3D jigsaw puzzle, DNA bending is achieved by solving an inverse kinematics problem. Our model is based on recent electron microscopy measurements of reconstituted fiber dimensions. Strikingly, we find that the chromatin fiber containing linker histones is a polymorphic structure. We show that different fiber conformations are obtained by tuning the linker histone orientation at the nucleosomes entry/exit according to the nucleosomal repeat length. We propose that the observed in vivo quantization of nucleosomal repeat length could reflect nature's ability to use the DNA molecule's helical geometry in order to give chromatin versatile topological and mechanical properties.
Mathematical modeling of Chikungunya fever control
Hincapié-Palacio, Doracelly; Ospina, Juan
2015-05-01
Chikungunya fever is a global concern due to the occurrence of large outbreaks, the presence of persistent arthropathy and its rapid expansion throughout various continents. Globalization and climate change have contributed to the expansion of the geographical areas where mosquitoes Aedes aegypti and Aedes albopictus (Stegomyia) remain. It is necessary to improve the techniques of vector control in the presence of large outbreaks in The American Region. We derive measures of disease control, using a mathematical model of mosquito-human interaction, by means of three scenarios: a) a single vector b) two vectors, c) two vectors and human and non-human reservoirs. The basic reproductive number and critical control measures were deduced by using computer algebra with Maple (Maplesoft Inc, Ontario Canada). Control measures were simulated with parameter values obtained from published data. According to the number of households in high risk areas, the goals of effective vector control to reduce the likelihood of mosquito-human transmission would be established. Besides the two vectors, if presence of other non-human reservoirs were reported, the monthly target of effective elimination of the vector would be approximately double compared to the presence of a single vector. The model shows the need to periodically evaluate the effectiveness of vector control measures.
无
2001-01-01
The genome length is a fundamental feature of a species. This note outlined the general concept and estimation method of the physical and genetic length. Some formulae for estimating the genetic length were derived in detail. As examples, the genome genetic length of Pinus pinaster Ait. and the genetic length of chromosome Ⅵ of Oryza sativa L. were estimated from partial linkage data.
Parametric uncertainty modeling for robust control
Rasmussen, K.H.; Jørgensen, Sten Bay
1999-01-01
The dynamic behaviour of a non-linear process can often be approximated with a time-varying linear model. In the presented methodology the dynamics is modeled non-conservatively as parametric uncertainty in linear lime invariant models. The obtained uncertainty description makes it possible...... method can be utilized in identification of a nominal model with uncertainty description. The method is demonstrated on a binary distillation column operating in the LV configuration. The dynamics of the column is approximated by a second order linear model, wherein the parameters vary as the operating...... to perform robustness analysis on a control system using the structured singular value. The idea behind the proposed method is to fit a rational function to the parameter variation. The parameter variation can then be expressed as a linear fractional transformation (LFT), It is discussed how the proposed...
Catalyst Deactivation: Control Relevance of Model Assumptions
Bernt Lie
2000-10-01
Full Text Available Two principles for describing catalyst deactivation are discussed, one based on the deactivation mechanism, the other based on the activity and catalyst age distribution. When the model is based upon activity decay, it is common to use a mean activity developed from the steady-state residence time distribution. We compare control-relevant properties of such an approach with those of a model based upon the deactivation mechanism. Using a continuous stirred tank reactor as an example, we show that the mechanistic approach and the population balance approach lead to identical models. However, common additional assumptions used for activity-based models lead to model properties that may deviate considerably from the correct one.
Nadimi, Esmaeil Sharak; Bak, Thomas; Izadi-Zamanabadi, Roozbeh
2006-01-01
The main objective of this paper is to investigate the erformance and applicability of two GPC (generalized predictive control) based control methods on a complete benchmark model of the Stewart platform made in MATLAB V6.5. The first method involves an LQG controller (Linear Quadratic Gaussian...
2013-03-01
polymer matrix composite materials display quite complex deformation and failure behavior under ballistic/blast impact loading conditions. This complexity is generally attributed to a number of factors such as (a) hierarchical/multi-length scale architecture of the material microstructure; (b) nonlinear, rate-dependent and often pressure-sensitive mechanical response; and (c) the interplay of various intrinsic phenomena and processes such as fiber twisting, interfiber friction/sliding, etc. Material models currently employed in the computational engineering
Microprocessor-controlled colonic peristalsis: dynamic parametric modeling in dogs.
Rashev, Peter Z; Amaris, Manuel; Bowes, Kenneth L; Mintchev, Martin P
2002-05-01
The study aimed at completing a model of functional colonic electric stimulation and testing it for artificial recreation of peristalsis in dogs. Dynamic measurements of invoked single contractions obtained from two unconscious dogs as well as previously reported static contraction properties were utilized to suggest the optimal stimulation parameters of: (1) length of the stimulating electrodes, (2) separation between the successive electrode sets, (3) duration, and (4) phase lag between the stimuli sequentially applied to the electrode sets. The derived electrode configuration and stimulation pattern were adjusted for different anatomical dimensions and tested in distended colon full of viscous content. Forward and backward propagating peristaltic waves were invoked in two other unconscious dogs, indicating that the recreation of colonic peristalsis under microprocessor control is feasible.
Optimal feedback scheduling of model predictive controllers
Pingfang ZHOU; Jianying XIE; Xiaolong DENG
2006-01-01
Model predictive control (MPC) could not be reliably applied to real-time control systems because its computation time is not well defined. Implemented as anytime algorithm, MPC task allows computation time to be traded for control performance, thus obtaining the predictability in time. Optimal feedback scheduling (FS-CBS) of a set of MPC tasks is presented to maximize the global control performance subject to limited processor time. Each MPC task is assigned with a constant bandwidth server (CBS), whose reserved processor time is adjusted dynamically. The constraints in the FSCBS guarantee scheduler of the total task set and stability of each component. The FS-CBS is shown robust against the variation of execution time of MPC tasks at runtime. Simulation results illustrate its effectiveness.
Exploring active flow control for efficient control of separation on an Ahmed model
McNally, Jonathan; Alvi, Farrukh
2016-11-01
Active flow control is applied to an Ahmed model with a rear slant angle of 25°, where a typical flow field consists of a three-dimensional separation region on the rear slant of the bluff body. Linear arrays of discrete microjets, previously proven to effectively control this separation, are investigated further. A principal aim of this experimental study is to examine the sensitivity of control as the actuator location is shifted with respect to the separation location. Aerodynamic force and surface pressure measurements, combined with the velocity field obtained using particle image velocimetry, provide a measure of control efficacy and insight into the interaction of jet arrays with the local flow field, including the separating shear layer. An energy balance is conducted to characterize control efficiency for multiple positions over a range of microjet array blowing conditions. Results show that moving the actuator array further into the separation region requires higher microjet momentum to obtain a desired aerodynamic benefit. An empirical relationship is also developed for determining the required jet velocity as a function of position by relating the jet penetration distance to local flow features and length scales. Partial support by FCAAP and NSF.
Youhua Chen
2016-09-01
Full Text Available In this report, a maximum likelihood model is developed to incorporate data uncertainty in response and explanatory variables when fitting power-law bivariate relationships in ecology and evolution. This simple likelihood model is applied to an empirical data set related to the allometric relationship between body mass and length of Sciuridae species worldwide. The results show that the values of parameters estimated by the proposed likelihood model are substantially different from those fitted by the nonlinear least-of-square (NLOS method. Accordingly, the power-law models fitted by both methods have different curvilinear shapes. These discrepancies are caused by the integration of measurement errors in the proposed likelihood model, in which NLOS method fails to do. Because the current likelihood model and the NLOS method can show different results, the inclusion of measurement errors may offer new insights into the interpretation of scaling or power laws in ecology and evolution.
2013-01-01
When a DNA molecule is stretched, the zero-force correlation length for its bending fluctuations – the persistence length A – bifurcates into two different correlation lengths - the shorter “longitudinal” correlation length ξ‖(f) and the longer “transverse” correlation length ξ⊥(f). In the high-force limit, ξ‖(f)=ξ⊥(f)/2=kBTA/f/2. When DNA-bending proteins bind to the DNA molecule, there is an effective interaction between the protein-generated bends mediated by DNA elasticity and bending fluctuations. Surprisingly, the range of this interaction is not the longest correlation length associated with transverse fluctuations of the tangent vector along the polymer, but instead is the second longest longitudinal correlation length ξ‖ (f, μ). The effect arises from the protein-bend contribution to the Hamiltonian having an axial rotational symmetry which eliminates its coupling to the transverse fluctuations. PMID:23368394
Modeling and Control of Underwater Robotic Systems
Schjoelberg, I:
1996-12-31
This doctoral thesis describes modeling and control of underwater vehicle-manipulator systems. The thesis also presents a model and a control scheme for a system consisting of a surface vessel connected to an underwater robotic system by means of a slender marine structure. The equations of motion of the underwater vehicle and manipulator are described and the system kinematics and properties presented. Feedback linearization technique is applied to the system and evaluated through a simulation study. Passivity-based controllers for vehicle and manipulator control are presented. Stability of the closed loop system is proved and simulation results are given. The equation of motion for lateral motion of a cable/riser system connected to a surface vessel at the top end and to a thruster at the bottom end is described and stability analysis and simulations are presented. The equations of motion in 3 degrees of freedom of the cable/riser, surface vessel and robotic system are given. Stability analysis of the total system with PD-controllers is presented. 47 refs., 32 figs., 7 tabs.
Han, Miaomiao; Guo, Zhirong; Liu, Haifeng; Li, Qinghua
2017-07-01
This paper studies the influence of different path length computation models and iterative reconstruction algorithms on the quality of transmission reconstruction in Tomographic Gamma Scanning. The research purpose is to quantify and to localize heterogeneous matrices while investigating the recovery of linear attenuation coefficients (LACs) maps in 200 liter drums. Two different path length computation models so called ;point to point (PP); model and ;point to detector (PD); model are coupled with two different transmission reconstruction algorithms - Algebraic Reconstruction Technique (ART) with non-negativity constraint, and Maximum Likelihood Expectation Maximization (MLEM), respectively. Thus 4 modes are formed: ART-PP, ART-PD, MLEM-PP, MLEM-PD. The inter-comparison of transmission reconstruction qualities of these 4 modes is taken into account for heterogeneous matrices in the radioactive waste drums. Results illustrate that transmission-reconstructed qualities of MLEM algorithm are better than ART algorithm to get the most accurate LACs maps in good agreement with the reference data simulated by Monte Carlo. Moreover, PD model can be used to assay higher density waste drum and has a greater scope of application than PP model in TGS.
Timo Vepsäläinen
2014-01-01
Full Text Available The scope and responsibilities of control applications are increasing due to, for example, the emergence of industrial internet. To meet the challenge, model-driven development techniques have been in active research in the application domain. Simulations that have been traditionally used in the domain, however, have not yet been sufficiently integrated to model-driven control application development. In this paper, a model-driven development process that includes support for design-time simulations is complemented with support for simulating sequential control functions. The approach is implemented with open source tools and demonstrated by creating and simulating a control system model in closed-loop with a large and complex model of a paper industry process.
Models, controls, and levels of semiotic autonomy
Joslyn, C.
1998-12-01
In this paper the authors consider forms of autonomy, forms of semiotic systems, and any necessary relations among them. Levels of autonomy are identified as levels of system identity, from adiabatic closure to disintegration. Forms of autonomy or closure in systems are also recognized, including physical, dynamical, functional, and semiotic. Models and controls are canonical linear and circular (closed) semiotic relations respectively. They conclude that only at higher levels of autonomy do semiotic properties become necessary. In particular, all control systems display at least a minimal degree of semiotic autonomy; and all systems with sufficiently interesting functional autonomy are semiotically related to their environments.
A Modified Model Predictive Control Scheme
Xiao-Bing Hu; Wen-Hua Chen
2005-01-01
In implementations of MPC (Model Predictive Control) schemes, two issues need to be addressed. One is how to enlarge the stability region as much as possible. The other is how to guarantee stability when a computational time limitation exists. In this paper, a modified MPC scheme for constrained linear systems is described. An offline LMI-based iteration process is introduced to expand the stability region. At the same time, a database of feasible control sequences is generated offline so that stability can still be guaranteed in the case of computational time limitations. Simulation results illustrate the effectiveness of this new approach.
Cano-Torres, Edgar A; Simental-Mendía, Luis E; Morales-Garza, Luis A; Ramos-Delgado, José M; Reyes-Gonzalez, Mirthala M; Sánchez-Nava, Victor M; Barragán-Berlanga, Abel de J; Rangel-Rodríguez, Ignacio; Guerrero-Romero, Fernando
2017-01-01
The objective of this study was to evaluate the impact of a nutritional intervention on hospital stay and mortality among hospitalized patients with malnutrition. Hospitalized patients with a diagnosis of malnutrition were enrolled and randomly allocated to either an intervention or control group. Participants in the intervention group received an individualized nutrition plan according to energy and protein (1.0-1.5 g/kg) intake requirements as well as dietary advice based on face-to-face interviews with patients and their caregivers or family members. Individuals in the control group received standard nutritional management according to the Hospital Nutrition Department. Nutritional status and disease severity were assessed using nutritional risk screening. Length of hospital stay was defined by the number of days of hospitalization from hospital admission to medical discharge. Reference to another service or death were criteria for study withdrawal. To evaluate mortality, individuals were followed up for 6 months after hospital discharge. Hospital stay and mortality were the intention-to-treat analysis. A total of 55 patients with an average age of 57.1 ± 20.7 years were included into intervention (n = 28) and control (n = 27) groups, respectively. At basal condition, nutritional status, measured by nutritional risk screening score, was similar between the study groups (4.1 ± 0.8 vs 4.2 ± 1.2, p = 0.6). The average hospital stay was lower in the intervention group compared to the control group (6.4 ± 3.0 vs 8.4 ± 4.0 days, p = 0.03). Finally, the mortality rate at 6 months of follow-up was similar in both groups (hazard ratio [HR] = 0.85; 95% confidence interval [CI], 0.17-4.21). Results of this study suggest that, in hospitalized patients with malnutrition, nutritional intervention and dietary advice decrease hospital stay but not mortality.
Zang, Xizhe; Liu, Yixiang; Heng, Shuai; Lin, Zhenkun; Zhao, Jie
2017-01-01
High-performance position control of pneumatic artificial muscles is limited by their inherent nonlinearity and hysteresis. This study aims to model the length/pressure hysteresis of a single pneumatic artificial muscle and to realize its accurate position tracking control with forward hysteresis compensation. The classical Prandtl-Ishlinskii model is widely used in hysteresis modelling and compensation. But it is only effective for symmetric hysteresis. Therefore, a modified Prandtl-Ishlinskii model is built to characterize the asymmetric length/pressure hysteresis of a single pneumatic artificial muscle, by replacing the classical play operators with two more flexible elementary operators to independently describe the ascending branch and descending branch of hysteresis loops. On the basis, a position tracking controller, which is composed of cascade forward hysteresis compensation and simple proportional pressure controller, is designed for the pneumatic artificial muscle. Experiment results show that the MPI model can reproduce the length/pressure hysteresis of the pneumatic artificial muscle, and the proposed controller for the pneumatic artificial muscle can track the reference position signals with high accuracy. By modelling the length/pressure hysteresis with the modified Prandtl-Ishlinskii model and using its inversion for compensation, precise position control of a single pneumatic artificial muscle is achieved.
Nonconvex Model Predictive Control for Commercial Refrigeration
Hovgaard, Tobias Gybel; Larsen, Lars F.S.; Jørgensen, John Bagterp
2013-01-01
is to minimize the total energy cost, using real-time electricity prices, while obeying temperature constraints on the zones. We propose a variation on model predictive control to achieve this goal. When the right variables are used, the dynamics of the system are linear, and the constraints are convex. The cost...... the iterations, which is more than fast enough to run in real-time. We demonstrate our method on a realistic model, with a full year simulation and 15 minute time periods, using historical electricity prices and weather data, as well as random variations in thermal load. These simulations show substantial cost...
Modeling and Control for Magnetostrictive Hysteresis
MAO Jian-qin; MA Yan-hua
2006-01-01
To deal with the rate-dependent hysteresis presented in a magnetostrictive actuator, a new method of modeling and control is proposed. The relationship between inputs and outputs of the actuator is approximately described by a dynamic differential equation with two rate-dependent coefficients, each expressed as a polynomial of frequency. For a given frequency, the coefficients will be able to be estimated by approximating the experimental data of the outputs of the magnetostrictive actuator. Based on this model, a quasi-PID controller is designed. In the space of the coefficients and frequency, the stable domain of closed loop system with hysteresis is analyzed. The numerical simulation and experiments have born witness to the feasibility of the proposed new method.
Snake Robots Modelling, Mechatronics, and Control
Liljebäck, Pål; Stavdahl, Øyvind; Gravdahl, Jan Tommy
2013-01-01
Snake Robots is a novel treatment of theoretical and practical topics related to snake robots: robotic mechanisms designed to move like biological snakes and able to operate in challenging environments in which human presence is either undesirable or impossible. Future applications of such robots include search and rescue, inspection and maintenance, and subsea operations. Locomotion in unstructured environments is a focus for this book. The text targets the disparate muddle of approaches to modelling, development and control of snake robots in current literature, giving a unified presentation of recent research results on snake robot locomotion to increase the reader’s basic understanding of these mechanisms and their motion dynamics and clarify the state of the art in the field. The book is a complete treatment of snake robotics, with topics ranging from mathematical modelling techniques, through mechatronic design and implementation, to control design strategies. The development of two snake robots is de...
CFD Modeling for Mercury Control Technology
Madsen, J.I.
2006-12-01
Compliance with the Clean Air Mercury Rule will require implementation of dedicated mercury control solutions at a significant portion of the U.S. coal-fired utility fleet. Activated Carbon Injection (ACI) upstream of a particulate control device (ESP or baghouse) remains one of the most promising near-term mercury control technologies. The DOE/NETL field testing program has advanced the understanding of mercury control by ACI, but a persistent need remains to develop predictive models that may improve the understanding and practical implementation of this technology. This presentation describes the development of an advanced model of in-flight mercury capture based on Computational Fluid Dynamics (CFD). The model makes detailed predictions of the induct spatial distribution and residence time of sorbent, as well as predictions of mercury capture efficiency for particular sorbent flow rates and injection grid configurations. Hence, CFD enables cost efficient optimization of sorbent injection systems for mercury control to a degree that would otherwise be impractical both for new and existing plants. In this way, modeling tools may directly address the main cost component of operating an ACI system – the sorbent expense. A typical 300 MW system is expected to require between $1 and $2 million of sorbent per year, and so even modest reductions (say 10-20%) in necessary sorbent feed injection rates will quickly make any optimization effort very worthwhile. There are few existing models of mercury capture, and these typically make gross assumptions of plug gas flow, zero velocity slip between particle and gas phase, and uniform sorbent dispersion. All of these assumptions are overcome with the current model, which is based on first principles and includes mass transfer processes occurring at multiple scales, ranging from the large-scale transport in the duct to transport within the porous structure of a sorbent particle. In principle any single one of these processes
Internal Model Based Active Disturbance Rejection Control
Pan, Jinwen; Wang, Yong
2016-01-01
The basic active disturbance rejection control (BADRC) algorithm with only one order higher extended state observer (ESO) proves to be robust to both internal and external disturbances. An advantage of BADRC is that in many applications it can achieve high disturbance attenuation level without requiring a detailed model of the plant or disturbance. However, this can be regarded as a disadvantage when the disturbance characteristic is known since the BADRC algorithm cannot exploit such informa...
Validation of Air Traffic Controller Workload Models
1979-09-01
SAR) tapes dtirinq the data reduc- tion phase of the project. Kentron International Limited provided the software support for the oroject. This included... ETABS ) or to revised traffic control procedures. The models also can be used to verify productivity benefits after new configurations have been...col- lected and processed manually. A preliminary compari- son has been made between standard NAS Stage A and ETABS operations at Miami. 1.2
Woochul Nam
Full Text Available Kinesins are molecular motors which walk along microtubules by moving their heads to different binding sites. The motion of kinesin is realized by a conformational change in the structure of the kinesin molecule and by a diffusion of one of its two heads. In this study, a novel model is developed to account for the 2D diffusion of kinesin heads to several neighboring binding sites (near the surface of microtubules. To determine the direction of the next step of a kinesin molecule, this model considers the extension in the neck linkers of kinesin and the dynamic behavior of the coiled-coil structure of the kinesin neck. Also, the mechanical interference between kinesins and obstacles anchored on the microtubules is characterized. The model predicts that both the kinesin velocity and run length (i.e., the walking distance before detaching from the microtubule are reduced by static obstacles. The run length is decreased more significantly by static obstacles than the velocity. Moreover, our model is able to predict the motion of kinesin when other (several motors also move along the same microtubule. Furthermore, it suggests that the effect of mechanical interaction/interference between motors is much weaker than the effect of static obstacles. Our newly developed model can be used to address unanswered questions regarding degraded transport caused by the presence of excessive tau proteins on microtubules.
Model Based Control of Refrigeration Systems
Larsen, Lars Finn Sloth
of the supermarket refrigeration systems therefore greatly relies on a human operator to detect and accommodate failures, and to optimize system performance under varying operational condition. Today these functions are maintained by monitoring centres located all over the world. Initiated by the growing need...... for automation of these procedures, that is to incorporate some "intelligence" in the control system, this project was started up. The main emphasis of this work has been on model based methods for system optimizing control in supermarket refrigeration systems. The idea of implementing a system optimizing.......e. by degrading the performance. The method has been successfully applied on a test frigeration system for minimization of the power consumption; the hereby gained experimental results will be presented. The present control structure in a supermarket refrigeration system is distributed, which means...
P. R. Parthasarathy
2001-01-01
Full Text Available The transient solution is obtained analytically using continued fractions for a state-dependent birth-death queue in which potential customers are discouraged by the queue length. This queueing system is then compared with the well-known infinite server queueing system which has the same steady state solution as the model under consideration, whereas their transient solutions are different. A natural measure of speed of convergence of the mean number in the system to its stationarity is also computed.
Stéphane Thanassekos
Full Text Available Antarctic krill (Euphausia superba; herein krill is monitored as part of an on-going fisheries observer program that collects length-frequency data. A krill feedback management programme is currently being developed, and as part of this development, the utility of data-derived indices describing population level processes is being assessed. To date, however, little work has been carried out on the selection of optimum recruitment indices and it has not been possible to assess the performance of length-based recruitment indices across a range of recruitment variability. Neither has there been an assessment of uncertainty in the relationship between an index and the actual level of recruitment. Thus, until now, it has not been possible to take into account recruitment index uncertainty in krill stock management or when investigating relationships between recruitment and environmental drivers. Using length-frequency samples from a simulated population - where recruitment is known - the performance of six potential length-based recruitment indices is assessed, by exploring the index-to-recruitment relationship under increasing levels of recruitment variability (from ±10% to ±100% around a mean annual recruitment. The annual minimum of the proportion of individuals smaller than 40 mm (F40 min, % was selected because it had the most robust index-to-recruitment relationship across differing levels of recruitment variability. The relationship was curvilinear and best described by a power law. Model uncertainty was described using the 95% prediction intervals, which were used to calculate coverage probabilities and assess model performance. Despite being the optimum recruitment index, the performance of F40 min degraded under high (>50% recruitment variability. Due to the persistence of cohorts in the population over several years, the inclusion of F40 min values from preceding years in the relationship used to estimate recruitment in a given year
Thanassekos, Stéphane; Cox, Martin J; Reid, Keith
2014-01-01
Antarctic krill (Euphausia superba; herein krill) is monitored as part of an on-going fisheries observer program that collects length-frequency data. A krill feedback management programme is currently being developed, and as part of this development, the utility of data-derived indices describing population level processes is being assessed. To date, however, little work has been carried out on the selection of optimum recruitment indices and it has not been possible to assess the performance of length-based recruitment indices across a range of recruitment variability. Neither has there been an assessment of uncertainty in the relationship between an index and the actual level of recruitment. Thus, until now, it has not been possible to take into account recruitment index uncertainty in krill stock management or when investigating relationships between recruitment and environmental drivers. Using length-frequency samples from a simulated population - where recruitment is known - the performance of six potential length-based recruitment indices is assessed, by exploring the index-to-recruitment relationship under increasing levels of recruitment variability (from ±10% to ±100% around a mean annual recruitment). The annual minimum of the proportion of individuals smaller than 40 mm (F40 min, %) was selected because it had the most robust index-to-recruitment relationship across differing levels of recruitment variability. The relationship was curvilinear and best described by a power law. Model uncertainty was described using the 95% prediction intervals, which were used to calculate coverage probabilities and assess model performance. Despite being the optimum recruitment index, the performance of F40 min degraded under high (>50%) recruitment variability. Due to the persistence of cohorts in the population over several years, the inclusion of F40 min values from preceding years in the relationship used to estimate recruitment in a given year improved its
Kristen D. Alexander
2012-01-01
Full Text Available We have employed capillary force deposition on ion beam patterned substrates to fabricate chains of 60 nm gold nanospheres ranging in length from 1 to 9 nanoparticles. Measurements of the surface-averaged SERS enhancement factor strength for these chains were then compared to the numerical predictions. The SERS enhancement conformed to theoretical predictions in the case of only a few chains, with the vast majority of chains tested not matching such behavior. Although all of the nanoparticle chains appear identical under electron microscope observation, the extreme sensitivity of the SERS enhancement to nanoscale morphology renders current nanofabrication methods insufficient for consistent production of coupled nanoparticle chains. Notwithstanding this fact, the aggregate data also confirmed that nanoparticle dimers offer a large improvement over the monomer enhancement while conclusively showing that, within the limitations imposed by current state-of-the-art nanofabrication techniques, chains comprising more than two nanoparticles provide only a marginal signal boost over the already considerable dimer enhancement.
He, Christine; Gállego, Isaac; Laughlin, Brandon; Grover, Martha A.; Hud, Nicholas V.
2017-04-01
Many hypotheses concerning the nature of early life assume that genetic information was once transferred through the template-directed synthesis of RNA, before the emergence of coded enzymes. However, attempts to demonstrate enzyme-free, template-directed synthesis of nucleic acids have been limited by 'strand inhibition', whereby transferring information from a template strand in the presence of its complementary strand is inhibited by the stability of the template duplex. Here, we use solvent viscosity to circumvent strand inhibition, demonstrating information transfer from a gene-length template (>300 nt) within a longer (545 bp or 3 kb) duplex. These results suggest that viscous environments on the prebiotic Earth, generated periodically by water evaporation, could have facilitated nucleic acid replication—particularly of long, structured sequences such as ribozymes. Our approach works with DNA and RNA, suggesting that viscosity-mediated replication is possible for a range of genetic polymers, perhaps even for informational polymers that may have preceded RNA.
Dowton, Mark; Austin, Andrew D
2002-02-01
Comprehensive phylogenetic analyses utilize data from distinct sources, including nuclear, mitochondrial, and plastid molecular sequences and morphology. Such heterogeneous datasets are likely to require distinct models of analysis, given the different histories of mutational biases operating on these characters. The incongruence length difference (ILD) test is increasingly being used to arbitrate between competing models of phylogenetic analysis in cases where multiple data partitions have been collected. Our work suggests that the ILD test is unlikely to be an effective measure of congruence when two datasets differ markedly in size. We show that models that increase the contribution of one data partition over another are likely to increase congruence, as measured by this test. More alarmingly, for many bipartition comparisons, character congruence increases bimodally - either increasing or decreasing the contribution of one data partition will increase congruence - making it impossible to arrive at a single optimally congruent model of analysis.
Knaapila, M.; Stepanyan, R.; Torkkeli, M.; Garamus, V. M.; Galbrecht, F.; Nehls, B. S.; Preis, E.; Scherf, U.; Monkman, A. P.
2008-05-01
We present guidelines on how the solution structure of π -conjugated hairy-rod polyfluorenes is controlled by the side-chain length and branching. First, the semiquantitative mean-field theory is formulated to predict the phase behavior of the system as a function of side-chain beads (N) . The phase transition at N=N∗ separates a lyotropic phase with solvent coexistence (NN∗) . The membrane phase transforms into the isotropic phase of dissolved rodlike polymers at the temperature Tmem∗(N) , which decreases both with N and with the degree of side-chain branching. This picture is complemented by polymer demixing with the transition temperature TIN∗(N) , which decreases with N . For NN∗ , stable membranes are predicted for TIN∗N∗ . Tmem∗(N) decreases from 340 K to 280 K for N≥8 . For copolymers, the membrane phase is found when the fraction of F8 units is at least 90%, Tmem∗ decreasing with this fraction. The membrane phase contains three material types: loose sheets of two polymer layers, a better packed β phase, and dissolved polymer. For N≥7 and T
Garrick Dorian J
2010-06-01
Full Text Available Abstract Background The distribution of residual effects in linear mixed models in animal breeding applications is typically assumed normal, which makes inferences vulnerable to outlier observations. In order to mute the impact of outliers, one option is to fit models with residuals having a heavy-tailed distribution. Here, a Student's-t model was considered for the distribution of the residuals with the degrees of freedom treated as unknown. Bayesian inference was used to investigate a bivariate Student's-t (BSt model using Markov chain Monte Carlo methods in a simulation study and analysing field data for gestation length and birth weight permitted to study the practical implications of fitting heavy-tailed distributions for residuals in linear mixed models. Methods In the simulation study, bivariate residuals were generated using Student's-t distribution with 4 or 12 degrees of freedom, or a normal distribution. Sire models with bivariate Student's-t or normal residuals were fitted to each simulated dataset using a hierarchical Bayesian approach. For the field data, consisting of gestation length and birth weight records on 7,883 Italian Piemontese cattle, a sire-maternal grandsire model including fixed effects of sex-age of dam and uncorrelated random herd-year-season effects were fitted using a hierarchical Bayesian approach. Residuals were defined to follow bivariate normal or Student's-t distributions with unknown degrees of freedom. Results Posterior mean estimates of degrees of freedom parameters seemed to be accurate and unbiased in the simulation study. Estimates of sire and herd variances were similar, if not identical, across fitted models. In the field data, there was strong support based on predictive log-likelihood values for the Student's-t error model. Most of the posterior density for degrees of freedom was below 4. Posterior means of direct and maternal heritabilities for birth weight were smaller in the Student's-t model
Yamaguchi, Fumiko; Watanabe, Shin-Ichi; Harada, Fusae; Miyake, Miyuki; Yoshida, Masaki; Okano, Tomomichi
2014-01-01
We investigated the effect of the alkyl-chain length of anionic surfactants on the skin using an in vitro model. The evaluated anionic surfactants were sodium alkyl sulfate (AS) and sodium fatty acid methyl ester sulfonate (MES), which had different alkyl-chain lengths (C8-C14). Skin tissue damage and permeability were examined using a reconstructed human epidermal model, LabCyte EPI-MODEL24. Skin tissue damage was examined by measuring cytotoxicity with an MTT assay. Liquid chromatography/tandem mass spectrometry (LC/MS-MS) and liquid chromatography/mass spectrometry (LC/MS) were used to detect surfactants that permeated into the assay medium through an epidermal model. To assess the permeation mechanism and cell damage caused by the surfactants through the epidermis, we evaluated the structural changes of Bovine Serum Albumin (BSA), used as a simple model protein, and the fluidity of 1,2-dipalmitoyl-sn-glycero-3-phosphpcholine (DPPC) liposome, which serves as one of the most abundant phospholipid models of living cell membranes in the epidermis. The effects of the surfactants on the proteins were measured using Circular Dichroism (CD) spectroscopy, while the effects on membrane fluidity were investigated by electron spin resonance (ESR) spectroscopy. ET50 (the 50% median effective time) increased as follows: C10 C12 > C14, for both AS and MES. For both AS and MES, the order parameter, which is the criteria for the microscopic viscosity of lipid bilayers, increased as follows: C10 C12 > C14. It was determined that the difference in skin tissue damage in the LabCyte EPI-MODEL24 with C10 to C14 AS and MES was caused by the difference in permeation and cell membrane fluidity through the lipid bilayer path in the epidermis.
Nitrogen Controls on Climate Model Evapotranspiration.
Dickinson, Robert E.; Berry, Joseph A.; Bonan, Gordon B.; Collatz, G. James; Field, Christopher B.; Fung, Inez Y.; Goulden, Michael; Hoffmann, William A.; Jackson, Robert B.; Myneni, Ranga; Sellers, Piers J.; Shaikh, Muhammad
2002-02-01
Most evapotranspiration over land occurs through vegetation. The fraction of net radiation balanced by evapotranspiration depends on stomatal controls. Stomates transpire water for the leaf to assimilate carbon, depending on the canopy carbon demand, and on root uptake, if it is limiting. Canopy carbon demand in turn depends on the balancing between visible photon-driven and enzyme-driven steps in the leaf carbon physiology. The enzyme-driven component is here represented by a Rubisco-related nitrogen reservoir that interacts with plant-soil nitrogen cycling and other components of a climate model. Previous canopy carbon models included in GCMs have assumed either fixed leaf nitrogen, that is, prescribed photosynthetic capacities, or an optimization between leaf nitrogen and light levels so that in either case stomatal conductance varied only with light levels and temperature.A nitrogen model is coupled to a previously derived but here modified carbon model and includes, besides the enzyme reservoir, additional plant stores for leaf structure and roots. It also includes organic and mineral reservoirs in the soil; the latter are generated, exchanged, and lost by biological fixation, deposition and fertilization, mineralization, nitrification, root uptake, denitrification, and leaching. The root nutrient uptake model is a novel and simple, but rigorous, treatment of soil transport and root physiological uptake. The other soil components are largely derived from previously published parameterizations and global budget constraints.The feasibility of applying the derived biogeochemical cycling model to climate model calculations of evapotranspiration is demonstrated through its incorporation in the Biosphere-Atmosphere Transfer Scheme land model and a 17-yr Atmospheric Model Inter comparison Project II integration with the NCAR CCM3 GCM. The derived global budgets show land net primary production (NPP), fine root carbon, and various aspects of the nitrogen cycling are
周杰; 潘成海; 黎燕; 王元宁
2014-01-01
Based on the precision roll forging of one coupler yoke ,the key problems of controlling the length of precision roll forgings were researched firstly with response surface method (RSM ) and fi-nite element method (FEM ) .First of all ,in order to meet the appropriate length of roll forgings and reduce the maximum torque of roller ,the second-order analysis model combined RSM and FEM was established in FORGE3 program ,and the influences of roller clearance ,friction factor ,roller speed and billet temperature on the length of roll forgings and the maximum torque of roller were studied . Secondly ,the roll forging was simulated with optimized process parameters ,the principle of debug-ging the length of roll forgings was firstly presented ,the roll forging dies were redesigned using the principle and point anti-tracking technology ,and the lengths of designed ,simulated and produced roll forgings and the power dissipation and distribution in one roll process were analyzed .The contrastive results of optimized simulation and products indicate that using RSM and FEM can accurately and ef-fectively grasp the technology of controlling the length of precision roll forgings .%以某钩尾框精密辊锻工艺为研究对象，首次应用响应面法（RSM ）和有限元数值模拟法（FEM ）对精密辊锻件的长度控制问题进行了研究。首先以满足辊锻件长度和降低轧辊最大扭矩为目标，采用FORGE3有限元软件建立了RSM与FEM相结合的二阶分析模型，研究了轧辊间隙、摩擦因子、轧辊转速和坯料温度对辊锻件的长度和轧辊最大扭矩的显著性和影响规律；其次采用优化后的工艺参数对该辊锻工艺进行了再模拟，提出了辊锻件长度的调试原则，利用该原则和点的反追踪技术对辊锻模具进行了再设计，同时分析了设计、模拟和生产辊锻件的长度和辊锻过程的功率耗散和分布。研究结果表明：应用RSM和FEM 可准确有效地
Krammer, Ramona; Heinzerling, Lucie
2014-01-01
New melanoma therapies, like e.g. ipilimumab, improve survival. However, only a small subset of patients benefits while 60% encounter side effects. Furthermore, these marginal benefits come at a very high price of €110'000 per treatment. This study examines attitudes towards melanoma therapy options of physicians, healthy individuals and patients, their willingness to pay and preference of quality versus length of life. Based on findings from a focus group questionnaires were developed and pretested. After obtaining ethical approval and informed consent surveys were conducted in a total of 90 participants (n = 30 for each group). Statistical analyses were conducted using R. Attitudes vastly differed between healthy participants, physicians and melanoma patients. Whereas melanoma patients show a high willingness to endure side effects despite very small survival gains (down to 1 extra week) or even only hope with no survival benefit, healthy controls are more critical, while physicians are the most therapy adverse. Consequently, if given €100'000 and the free decision what to spend the money on the willingness to pay for therapy was much higher in the patient group (68%) compared to 28% of healthy controls and only 43% of the physicians, respectively. When lowering the amount of cash that could be received instead of ipilimumab to €50'000 or €10'000 to test price sensitivity 69% (+1%) and 76% (+8%) of melanoma patients, respectively, preferred ipilimumab over cash. When judging on societal spending even melanoma patients opted for spending on ipilimumab in only 21%. The judgment about the benefits of new treatment options largely differs between groups, physicians being the most critical against therapy. Price elasticity was low.
Salgado Yepez, Estuardo; Bovera, Maria M; Rosenthal, Victor D; González Flores, Hugo A; Pazmiño, Leonardo; Valencia, Francisco; Alquinga, Nelly; Ramirez, Vanessa; Jara, Edgar; Lascano, Miguel; Delgado, Veronica; Cevallos, Cristian; Santacruz, Gasdali; Pelaéz, Cristian; Zaruma, Celso; Barahona Pinto, Diego
2017-01-01
AIM To report the results of the International Nosocomial Infection Control Consortium (INICC) study conducted in Quito, Ecuador. METHODS A device-associated healthcare-acquired infection (DA-HAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units (ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network (CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection (CLABSI) rate was 6.5 per 1000 central line (CL)-days, the ventilator-associated pneumonia (VAP) rate was 44.3 per 1000 mechanical ventilator (MV)-days, and the catheter-associated urinary tract infection (CAUTI) rate was 5.7 per 1000 urinary catheter (UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9 (CLABSI) and 5.3 (CAUTI)] and higher than NHSN rates [0.8 (CLABSI) and 1.3 (CAUTI)] - although device use ratios for CL and UC were higher than INICC and CDC/NSHN’s ratios. By contrast, despite the VAP rate was higher than INICC (16.5) and NHSN’s rates (1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. PMID:28289522
Johnson, Erik A.; Elhaddad, Wael M.; Wojtkiewicz, Steven F.
2016-04-01
A variety of strategies have been developed over the past few decades to determine controllable damping device forces to mitigate the response of structures and mechanical systems to natural hazards and other excitations. These "smart" damping devices produce forces through passive means but have properties that can be controlled in real time, based on sensor measurements of response across the structure, to dramatically reduce structural motion by exploiting more than the local "information" that is available to purely passive devices. A common strategy is to design optimal damping forces using active control approaches and then try to reproduce those forces with the smart damper. However, these design forces, for some structures and performance objectives, may achieve high performance by selectively adding energy, which cannot be replicated by a controllable damping device, causing the smart damper performance to fall far short of what an active system would provide. The authors have recently demonstrated that a model predictive control strategy using hybrid system models, which utilize both continuous and binary states (the latter to capture the switching behavior between dissipative and non-dissipative forces), can provide reductions in structural response on the order of 50% relative to the conventional clipped-optimal design strategy. This paper explores the robustness of this newly proposed control strategy through evaluating controllable damper performance when the structure model differs from the nominal one used to design the damping strategy. Results from the application to a two-degree-of-freedom structure model confirms the robustness of the proposed strategy.