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Sample records for lejringsskader hos rygopererede

  1. Lejringsskader hos rygopererede patienter

    DEFF Research Database (Denmark)

    Sestoft, Bodil; Larsen, Birgit; Erlandsen, Mogens

    2009-01-01

    INTRODUCTION: The aim of this study was to answer the questions: Which kind of positioning injuries occurred in anaesthetized orthopaedic patients undergoing spine surgery who were prone-positioned for more than two hours? What was the incidence of positioning injuries? Which patients were at par...

  2. Måling af stress hos mink

    DEFF Research Database (Denmark)

    Malmkvist, Jens

    2010-01-01

    Sammendrag Stress indgår som et element ved vurdering af dyrevelfærd. Endvidere kan stress mål anvendes i undersøgelser, hvor forskellige typer af avl, burmiljø og pasning af mink sammenlignes. Men hvad er stress egentlig og hvordan måles det? Er unormal adfærd koblet til stress hos mink? På...... temadagen præsenteres nye resultater og metoder til at vurdere stress hos mink. I en metode måles koncentrationen af nedbrydningsprodukter af hormonet cortisol i gødning fra mink. Der er en række fordele ved denne metode, frem for blodprøvetagning. Forsøg viste, at hovedparten af cortisol udskilles i fæces...... (83 %) frem for i urin (17 %), samt at omsætningen af radioaktivt mærket cortisol ikke er forskellig mellem mink med hhv. lav og høj forekomst af stereotypi. Denne viden kan bruges til bedre at forstå koblingen f.eks. unormal adfærd og stress hos mink....

  3. Vitamin D fysiologi og forsyning hos malkekvæg

    DEFF Research Database (Denmark)

    Hymøller, Lone; Jensen, Søren Krogh

    2015-01-01

    Vitamin D, som tilhører gruppen af fedtopløselige vitaminer, har de seneste år været et af de mest omdiskuterede næringsstoffer i både dansk og udenlandsk presse. Dette skyldes, at vitamin D har vist sig at have indflydelse på mange forskellige fysiologiske processer i kroppen lige fra...... kalciumbalance og knoglestyrke til immunforsvarets funktion. Hos malkekvæg betyder dette, at vitamin D potentielt har stor indflydelse på bl.a. risikoen for kælvningsproblemer og mælkefeber hos køer samt dyrenes generelle holdbarhed og sundhed. Gennem de seneste 10 år har forskere på AU Foulum intenst studeret...... vitamin D-forsyningen og -fysiologien hos malkekvæg. Resultaterne af disse undersøgelser har vist, at sommersollys er en meget vigtig kilde til vitamin D hos malkekøer, og der er en lineært stigende effekt på køernes vitamin D-status i blodet, jo længere tid de dagligt opholder sig i sommersolen. Tilskud...

  4. Ivermektinfølsomhed hos danske Collies og Border Collies

    DEFF Research Database (Denmark)

    Treschow, Michaela E. C.; Fredholm, Merete

    2007-01-01

    Anvendelse af ivermektin i terapeutiske doser til hunde medfører i visse tilfælde neurologiske bivirkninger. Der er tale om en idiosynkrasi, der benævnes ivermektinfølsomhed, og som primært er beskrevet hos hyrdehunderacer, herunder især Collies......Anvendelse af ivermektin i terapeutiske doser til hunde medfører i visse tilfælde neurologiske bivirkninger. Der er tale om en idiosynkrasi, der benævnes ivermektinfølsomhed, og som primært er beskrevet hos hyrdehunderacer, herunder især Collies...

  5. Identifiable Data Files - Health Outcomes Survey (HOS)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medicare Health Outcomes Survey (HOS) identifiable data files are comprised of the entire national sample for a given 2-year cohort (including both respondents...

  6. Medieforbrug hos etniske minoriteter I Danmark

    DEFF Research Database (Denmark)

    Christiansen, Connie Carøe

    2005-01-01

    Bag spørgsmålet om etniske minoriteters medieforbrug ligger en forventning om et anderledes forbrug end den øvrige befolkning og det bekræftes af forskellige undersøgelser. Der er større spredning på medier hos disse dele af befolkningen, og især tyrkiske familier ser megen tv fra hjemlandet. Men...

  7. Strubelammelse hos hund

    DEFF Research Database (Denmark)

    Miles, James; Eriksen, Thomas

    2007-01-01

    Strubelammelse (larynxparese) er en dysfunktion af strubehovedet, der medfører en stærkt nedsat eller som oftest helt fraværende evne til at åbne stemmeridsen (rima glottidis) ved inspiration. De lammede stemmebånd står immobile i paramedian stilling, hvilket medfører begrænset og besværet...... og hoste. Strubelammelse er enten medfødt eller erhvervet. Den medfødte form udgør 20-30 procent af patienter, hvor symptomerne debuterer hos unge dyr med kraftig ophobning i racer som Bouvier de Flandre, Siberian husky, Dalmatiner og Bull terrier. Den erhvervede lammelse er den hyppigste form og ses...

  8. The Arabidopsis E3 Ubiquitin Ligase HOS1 Negatively Regulates CONSTANS Abundance in the Photoperiodic Control of Flowering[W

    Science.gov (United States)

    Lazaro, Ana; Valverde, Federico; Piñeiro, Manuel; Jarillo, Jose A.

    2012-01-01

    The Arabidopsis thaliana early in short days6 (esd6) mutant was isolated in a screen for mutations that accelerate flowering time. Among other developmental alterations, esd6 displays early flowering in both long- and short-day conditions. Fine mapping of the mutation showed that the esd6 phenotype is caused by a lesion in the HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 (HOS1) locus, which encodes a RING finger–containing E3 ubiquitin ligase. The esd6/hos1 mutation causes decreased FLOWERING LOCUS C expression and requires CONSTANS (CO) protein for its early flowering phenotype under long days. Moreover, CO and HOS1 physically interact in vitro and in planta, and HOS1 regulates CO abundance, particularly during the daylight period. Accordingly, hos1 causes a shift in the regular long-day pattern of expression of FLOWERING LOCUS T (FT) transcript, starting to rise 4 h after dawn in the mutant. In addition, HOS1 interacts synergistically with CONSTITUTIVE PHOTOMORPHOGENIC1, another regulator of CO protein stability, in the regulation of flowering time. Taken together, these results indicate that HOS1 is involved in the control of CO abundance, ensuring that CO activation of FT occurs only when the light period reaches a certain length and preventing precocious flowering in Arabidopsis. PMID:22408073

  9. Årsager til luftvejsinfektioner hos kalve

    DEFF Research Database (Denmark)

    Sloth, Karen Helle; Fisker, Irene; Larsen, Lars Erik

    2008-01-01

    Coronavirus gav anledning til flest antistofstigninger hos nyindsatte kalve i tre ud af fire slagtekalvebesætninger i en mindre undersøgelse gennemført i et Dansk Kvæg projekt. I en af besætningerne var der desuden tydelig reaktion mod andre infektioner. Der blev undersøgt for antistoffer mod cor...... coronavirus, BRSV, parainfluenzavirus (P1-2) og Salmonelle dublin....

  10. Eosinofil keratitis hos en dansk hest

    DEFF Research Database (Denmark)

    Olsen, Emil; Henriksen, Michala de Linde; Andersen, Pia Haubro

    2009-01-01

    Eosinofil keratitis (EK) er en relativt sjælden øjenlidelse hos hest, som især ses i tempererede områder. Klinisk er lidelsen karakteriseret ved én eller multiple corneaulcerationer dækket med hvidt eller gelatinøst proliferativt subepithelialt plaque. Denne casereport, som omhandler en 20-årig p...

  11. HosA, a MarR Family Transcriptional Regulator, Represses Nonoxidative Hydroxyarylic Acid Decarboxylase Operon and Is Modulated by 4-Hydroxybenzoic Acid.

    Science.gov (United States)

    Roy, Ajit; Ranjan, Akash

    2016-02-23

    Members of the Multiple antibiotic resistance Regulator (MarR) family of DNA binding proteins regulate transcription of a wide array of genes required for virulence and pathogenicity of bacteria. The present study reports the molecular characterization of HosA (Homologue of SlyA), a MarR protein, with respect to its target gene, DNA recognition motif, and nature of its ligand. Through a comparative genomics approach, we demonstrate that hosA is in synteny with nonoxidative hydroxyarylic acid decarboxylase (HAD) operon and is present exclusively within the mutS-rpoS polymorphic region in nine different genera of Enterobacteriaceae family. Using molecular biology and biochemical approach, we demonstrate that HosA binds to a palindromic sequence downstream to the transcription start site of divergently transcribed nonoxidative HAD operon and represses its expression. Furthermore, in silico analysis showed that the recognition motif for HosA is highly conserved in the upstream region of divergently transcribed operon in different genera of Enterobacteriaceae family. A systematic chemical search for the physiological ligand revealed that 4-hydroxybenzoic acid (4-HBA) interacts with HosA and derepresses HosA mediated repression of the nonoxidative HAD operon. Based on our study, we propose a model for molecular mechanism underlying the regulation of nonoxidative HAD operon by HosA in Enterobacteriaceae family.

  12. The Hos2 Histone Deacetylase Controls Ustilago maydis Virulence through Direct Regulation of Mating-Type Genes.

    Directory of Open Access Journals (Sweden)

    Alberto Elías-Villalobos

    2015-08-01

    Full Text Available Morphological changes are critical for host colonisation in plant pathogenic fungi. These changes occur at specific stages of their pathogenic cycle in response to environmental signals and are mediated by transcription factors, which act as master regulators. Histone deacetylases (HDACs play crucial roles in regulating gene expression, for example by locally modulating the accessibility of chromatin to transcriptional regulators. It has been reported that HDACs play important roles in the virulence of plant fungi. However, the specific environment-sensing pathways that control fungal virulence via HDACs remain poorly characterised. Here we address this question using the maize pathogen Ustilago maydis. We find that the HDAC Hos2 is required for the dimorphic switch and pathogenic development in U. maydis. The deletion of hos2 abolishes the cAMP-dependent expression of mating type genes. Moreover, ChIP experiments detect Hos2 binding to the gene bodies of mating-type genes, which increases in proportion to their expression level following cAMP addition. These observations suggest that Hos2 acts as a downstream component of the cAMP-PKA pathway to control the expression of mating-type genes. Interestingly, we found that Clr3, another HDAC present in U. maydis, also contributes to the cAMP-dependent regulation of mating-type gene expression, demonstrating that Hos2 is not the only HDAC involved in this control system. Overall, our results provide new insights into the role of HDACs in fungal phytopathogenesis.

  13. Nanotubo de carbono-chitosan en células HOS y THP-1 Carbon nanotubes-chitosan in HOS and THP-1 cells

    Directory of Open Access Journals (Sweden)

    John Jairo Castillo León

    2011-04-01

    Full Text Available Introducción: Los nanotubos de carbono (NTC son estructuras nanométricas utilizadas en el tratamiento de enfermedades, principalmente en la entrega de fármacos para terapias en cáncer. Objetivos: Estudiar la internalización de NTC acoplado a quitosan (NTC-Q en células de osteosarcoma humano (HOS y monocitos humanos de leucemia aguda (THP-1. Materiales y métodos: Los NTC solubilizados con quitosan 30% fueron caracterizados espectroscópicamente por UV-Vis, fluorescencia y Raman. Las células HOS y THP-1 fueron tratadas con NTC-Q y se evaluó la internalización por tinción de Giemsa en microscopio de luz y la citotóxicidad utilizando la prueba fluorométrica de Azul de Alamar. Resultados: Los espectros Raman y de fluorescencia mostraron la funcionalización de los NTC con quitosan. Los NTC fueron internalizados por las líneas celulares después de 24 h mostrando una ubicación citoplasmática sin presentar citotóxicidad en ninguna de las células evaluadas. Discusión: Las características presentadas por los NTC-Q les brinda la posibilidad de ser utilizados como transportadores de fármacos. Salud UIS 2011; 43(1: 21-26Introduction: Carbon nanotubes (CNT are nanometer-sized structures used in medicine in the treatment of diseases, mainly in drug delivery in therapies against cancer. Objectives: To Study the internalization of carbon nanotubes modified with chitosan (CNT-CH in human osteosarcom cells (HOS and human monocytes of acute leukemia (THP1. Materials and methods: The CNTs solubilized in chitosan 30% were characterized spectroscopically by UV-Vis, fluorescence and Raman. HOS cells and THP-1 were treated with CNT-CH, the internalization was evaluated by Giemsa staining with light microscopy, and cytotoxicity was determined using Alamar Blue assay. Results: Raman and fluorescence spectra showed the functionalization of the CNT with chitosan. After 24 h the NTC were internalized in the cell lines showing a cytoplasmic location and

  14. Functional characterization of Candida albicans Hos2 histone deacetylase [v3; ref status: indexed, http://f1000r.es/3xh

    Directory of Open Access Journals (Sweden)

    G Karthikeyan

    2014-07-01

    Full Text Available Candida albicans is a mucosal commensal organism capable of causing superficial (oral and vaginal thrush infections in immune normal hosts, but is a major pathogen causing systemic and mucosal infections in immunocompromised individuals. Azoles have been very effective anti-fungal agents and the mainstay in treating opportunistic mold and yeast infections. Azole resistant strains have emerged compromising the utility of this class of drugs. It has been shown that azole resistance can be reversed by the co-administration of a histone deacetylase (HDAC inhibitor, suggesting that resistance is mediated by epigenetic mechanisms possibly involving Hos2, a fungal deacetylase. We report here the cloning and functional characterization of HOS2 (HighOsmolarity Sensitive, a gene coding for fungal histone deacetylase from C. albicans. Inhibition studies showed that Hos2 is susceptible to pan inhibitors such as trichostatin A (TSA and suberoylanilide hydroxamic acid (SAHA, but is not inhibited by class I inhibitors such as MS-275. This in vitro enzymatic assay, which is amenable to high throughput could be used for screening potent fungal Hos2 inhibitors that could be a potential anti-fungal adjuvant. Purified Hos2 protein consistently deacetylated tubulins, rather than histones from TSA-treated cells. Hos2 has been reported to be a putative NAD+ dependent histone deacetylase, a feature of sirtuins. We assayed for sirtuin activation with resveratrol and purified Hos2 protein and did not find any sirtuin activity.

  15. Emerging countries’ multinational companies investing in developed countries: at odds with the HOS paradigm?

    Directory of Open Access Journals (Sweden)

    Andreff, Wladimir

    2013-04-01

    Full Text Available The paper analyses the new trend of outward foreign direct investment (FDI by multinational companies from emerging countries, in particular the BRICs, in developed countries to question the applicability of the traditional HOS theoretical framework to this trend. A literature review shows that labour costs do not play any significant role in the first attempts to provide an analytical explanation of this new trend. A HOS equation, amended in order to encompass FDI, is elaborated in order to explain outward FDI from developed to developing and emerging countries based on differences in labour endowment and therefore in wage rates. Step by step, the equation introduces the technological gap, institutions and government policies. Then it is shown that such equation when reversed to explain outward FDI from emerging to developed countries is at odds with the traditional HOS framework. Turning the HOS theory upside down does not help to explain reverse FDI outflows from emerging to developed countries. An alternative approach is called for, in which a labour cost advantage (a lower wage rate than abroad is a home market advantage for emerging countries to invest abroad. A final section provides some empirical examples that labour matters and a lower home wage rate is a decisive comparative advantage for Indian and Chinese multinationals investing in developed countries. Additional evidence shows that the technological gap and the home country’s institutions and government policy matter as well

  16. Tværprofessionelt samarbejde om udsathed hos børn og unge

    DEFF Research Database (Denmark)

    Villumsen, Anne Marie Anker; Jakobsen, Ida Skytte; Lund, Jens Hansen

    2015-01-01

    begreb og fænomen, som ikke lader sig indfange i en absolut og statisk definition. Potentialet for både praksis og uddannelser ligger derfor i en erkendelse heraf. Samtidig synes der at være potentiale i, at man i hver enkelt samarbejdskonstellation og kontekst operationaliserer og præciserer......, at tværprofessionelt samarbejde er meget udbredt indenfor socialt arbejde med udsathed hos børn og unge, og det er tydeligt, at der er mange måder, hvorpå man kan samarbejde tværprofessionelt. Samtidig er både tværprofessionelt samarbejde såvel som udsathed hos børn og unge begge vanskelige og upræcise begreber og...

  17. Drænbehandling af recidiverende otitis media hos børn

    DEFF Research Database (Denmark)

    Lous, Jørgen; Trankjær, Christina Ryborg; Thomsen, Janus Laust

    2010-01-01

    I et nyligt publiceret Cochrane-review om effekten af indsættelse af trommehindedræn hos børn med recidiverende akut otitis media (RAOM) fandt man kun to studier, som opfyldte inklusionskriterierne. De inkluderede studier påviste en absolut risikoreduktion for at få AOM på 0,34 på seks måneder. Ved...

  18. Standardiserat arbete i produktionssystemet hos Inission Munkfors AB

    OpenAIRE

    Jonas, Arnesson

    2014-01-01

    Sammanfattning Denna rapport behandlar införandet av standardiserat arbete i produktionssystemet hos företaget Inission Munkfors AB. Arbetet har utförts i kursen Examensarbete för högskoleingenjörsexamen i maskinteknik (MSGC17), som ges vid Fakulteten för hälsa, natur & teknikvetenskap på Karlstads universitet.Företaget Inission Munkfors AB har som mål att från år 2012 till år 2017 kunna fördubbla omsättningen och halvera ledtiden, med samma personalstyrka som år 2012 (75st anställda). De...

  19. Skadelig mutation nedsætter frughtbarheden hos de røde racer

    DEFF Research Database (Denmark)

    Sahana, Goutam; Pedersen, Louise Dybdahl

    2014-01-01

    Igennem flere årtier er mælkeydelsen steget støt hos de danske malkekvægracer, og det er én af årsagerne til, at frugtbarheden fortsat er lav, idet der er en ugunstig sammenhæng mellem mælkeydelse og frugtbarhed (fig. 1). Hidtil har man ment, at den ugunstige sammenhæng skyldtes en negativ energi...

  20. HOS cell adhesion on Ti6Al4V surfaces texturized by laser engraving

    Science.gov (United States)

    Sandoval Amador, A.; Carreño Garcia, H.; Escobar Rivero, P.; Peña Ballesteros, D. Y.; Estupiñán Duran, H. A.

    2016-02-01

    The cell adhesion of the implant is determinate by the chemical composition, topography, wettability, surface energy and biocompatibility of the biomaterial. In this work the interaction between human osteosarcoma HOS cells and textured Ti6Al4V surfaces were evaluated. Ti6Al4V surfaces were textured using a CO2 laser in order to obtain circular spots on the surfaces. Test surfaces were uncoated (C1) used as a control surface, and surfaces with points obtained by laser engraving, with 1mm spacing (C2) and 0.5mm (C3). The HOS cells were cultured in RPMI-1640 medium with 10% fetal bovine serum and 1% antibiotics. No cells toxicity after one month incubation time occurred. The increased cell adhesion and cell spreading was observed after 1, 3 and 5 days without significant differences between the sample surfaces (C2 and C3) and control (uncoated) at the end of the experiment.

  1. HOS cell adhesion on Ti6Al4V surfaces texturized by laser engraving

    International Nuclear Information System (INIS)

    Sandoval Amador, A; Carreño Garcia, H; Escobar Rivero, P; Peña Ballesteros, D Y; Estupiñán Duran, H A

    2016-01-01

    The cell adhesion of the implant is determinate by the chemical composition, topography, wettability, surface energy and biocompatibility of the biomaterial. In this work the interaction between human osteosarcoma HOS cells and textured Ti 6 Al 4 V surfaces were evaluated. Ti 6 Al 4 V surfaces were textured using a CO 2 laser in order to obtain circular spots on the surfaces. Test surfaces were uncoated (C1) used as a control surface, and surfaces with points obtained by laser engraving, with 1mm spacing (C2) and 0.5mm (C3). The HOS cells were cultured in RPMI-1640 medium with 10% fetal bovine serum and 1% antibiotics. No cells toxicity after one month incubation time occurred. The increased cell adhesion and cell spreading was observed after 1, 3 and 5 days without significant differences between the sample surfaces (C2 and C3) and control (uncoated) at the end of the experiment. (paper)

  2. HOS cell adhesion on Ti6Al4V ELI texturized by CO2 laser

    Science.gov (United States)

    Sandoval-Amador, A.; Bayona–Alvarez, Y. M.; Carreño Garcia, H.; Escobar-Rivero, P.; Y Peña-Ballesteros, D.

    2017-12-01

    In this work, the response of HOS cells on Ti6Al4V ELI textured surfaces by a CO2 laser was evaluated. The test surfaces were; smooth Ti6Al4V, used as the control, and four textured surfaces with linear geometry. These four surfaces had different separation distances between textured lines, D1 (1000 microns), D2 (750 microns), D3 (500 microns) and D4 (250 microns). Toxicity of textured surfaces was assessed by MTT and the cellular adhesion test was performed using HOS ATCC CRL 1543 line cells. This test was done after 5 days of culture in a RPMI 1640 medium supplemented with 10% fetal bovine serum and 1% antibiotics. The results showed that the linear textures present 23% toxicity after 30 days of incubation, nevertheless, the adhesion tests results are inconclusive in such conditions and therefore the effect of the line separation on the cell adhesion cannot be determined.

  3. Sæsontilpasninger i stofsikftet reducerer lyskravet hos ålegræs (Zostera marina)

    DEFF Research Database (Denmark)

    Stæhr, Peter A.; Borum, Jens

    temperaturer for respiration og fotosyntese hos sommertilpassede planter (5oC og 2o C højere, respektivt). Ved lave og høje temperaturer var metabolisme raterne dog nedsatte i fht vintertilpassede planter. Respirationen var generelt mere følsom end fotosyntesen over for stigende temperaturer, især...... stigende temperaturer, særligt udtalt for vintertilpassede planter. Modeller af EC som funktion af temperaturen for hele planter, blev sammenholdt med data for daglig lys tilgængelighed. Dette viste at de relativt beskedne sæsonbetingede tilpasninger i stofskiftet hos ålegræs var tilstrækkelige til...... beregnet under forskellige kombinationer af sommer temperaturer og lyssvækkelse i vandsøjlen, viste at en forventet temperaturstigning på 5oC har markant mindre betydning for den maksimale dybdeudbredelse af ålegræs end relativt små forringelser i planternes lystilgængelighed. Kombinationen af varmere...

  4. Mestring i morsrollen - En kvalitativ studie av mestringsopplevelser hos nybakte mødre

    OpenAIRE

    Grønlie, Birgitte Vigestad

    2015-01-01

    Master i sosialt arbeid Å bli forelder kan være en overveldende opplevelse. Forskning på̊ feltet viser at det er ulike faktorer som påvirker hvordan mødre i dag opplever barselperioden, og hva som fører til god eller dårlig psykisk helse hos kvinner i barsel. Denne mastergradsoppgaven omhandler hvordan fem nybakte mødre beskriver mestringsopplevelser...

  5. Anden-ordens false belief og sproglig rekursion hos børn med Autisme Spektrum Forstyrrelser

    DEFF Research Database (Denmark)

    Polyanskaya, Irina

    2017-01-01

    En tværfaglig forskningsgruppe fra Roskilde Universitet undersøger forbindelsen mellem udviklingen af sprog og udviklingen af socialkognitive evner hos børn med Autisme Spektrum Forstyrrelser. Projektet er støttet af VELUX FONDEN, og bag projektet står psykolog og ph.d.-studerende Irina Polyanskaya...

  6. 76 FR 37876 - Hours of Service (HOS) of Drivers; Renewal of American Pyrotechnics Association (APA) Exemption...

    Science.gov (United States)

    2011-06-28

    ...-28043] Hours of Service (HOS) of Drivers; Renewal of American Pyrotechnics Association (APA) Exemption... announces the renewal of the exemption of specified members of the American Pyrotechnics Association (APA... of this exemption in effect, designated APA-member motor carriers will maintain a level of safety...

  7. 76 FR 30232 - Hours of Service (HOS) of Drivers; Application of American Pyrotechnics Association (APA) for...

    Science.gov (United States)

    2011-05-24

    ...-28043] Hours of Service (HOS) of Drivers; Application of American Pyrotechnics Association (APA) for... American Pyrotechnics Association (APA) has applied for a limited exemption from FMCSA's regulation that... exemption would apply solely to the operation of CMVs by 9 designated APA-member motor carriers in...

  8. 77 FR 38378 - Hours of Service (HOS) of Drivers; Revision of Exemption; American Pyrotechnics Association (APA)

    Science.gov (United States)

    2012-06-27

    ...-28043] Hours of Service (HOS) of Drivers; Revision of Exemption; American Pyrotechnics Association (APA... Pyrotechnics Association (APA) that were granted an exemption from FMCSA's prohibition on driving commercial...-July 8, inclusive, in 2011 and 2012. The exemption covered renewal of 53 APA-member motor carriers and...

  9. 76 FR 37880 - Hours of Service (HOS) of Drivers; Granting of Exemption; American Pyrotechnics Association (APA)

    Science.gov (United States)

    2011-06-28

    ...-28043] Hours of Service (HOS) of Drivers; Granting of Exemption; American Pyrotechnics Association (APA... exemption from the American Pyrotechnics Association (APA) on behalf of 9 member motor carriers seeking... such exemption'' (49 U.S.C. 31315(b)(1)). The initial APA application for waiver or exemption relief...

  10. Frihet & struktur : en kvalitativ studie av skolelivskvalitet hos ungdom med Tourette syndrom

    OpenAIRE

    Siverts, Torstein

    2005-01-01

    Sammendrag. Tittel: Skolelivskvalitet hos ungdom med Tourette Syndrom Med bakgrunn i egen erfaring fra arbeid med elever med Tourette Syndrom i grunnskolen, og i studier i spesialpedagogisk teori og empiri, etterstrebes det i denne studien å utvikle økt forståelse for hva slags erfaringer fra og perspektiver på sitt skoleliv elever med denne funksjonshemmende lidelsen har. Med grunnlag i analyser av intervjuer med elever om deres erfaringer og perspektiver, har jeg prøvd å b...

  11. The RNA-binding protein HOS5 and serine/arginine-rich proteins RS40 and RS41 participate in miRNA biogenesis in Arabidopsis

    KAUST Repository

    Chen, Tao

    2015-07-30

    MicroRNAs are a class of small regulatory RNAs that are generated from primary miRNA (pri-miRNA) transcripts with a stem-loop structure. Accuracy of the processing of pri-miRNA into mature miRNA in plants can be enhanced by SERRATE (SE) and HYPONASTIC LEAVES 1 (HYL1). HYL1 activity is regulated by the FIERY2 (FRY2)/RNA polymerase II C-terminal domain phosphatase-like 1 (CPL1). Here, we discover that HIGH OSMOTIC STRESS GENE EXPRESSION 5 (HOS5) and two serine/arginine-rich splicing factors RS40 and RS41, previously shown to be involved in pre-mRNA splicing, affect the biogenesis of a subset of miRNA. These proteins are required for correct miRNA strand selection and the maintenance of miRNA levels. FRY2 dephosphorylates HOS5 whose phosphorylation status affects its subnuclear localization. HOS5 and the RS proteins bind both intronless and intron-containing pri-miRNAs. Importantly, all of these splicing-related factors directly interact with both HYL1 and SE in nuclear splicing speckles. Our results indicate that these splicing factors are directly involved in the biogenesis of a group of miRNA.

  12. Alkohol, medicin og narkotikaforekomst hos alvorligt tilskadekomne bilister

    DEFF Research Database (Denmark)

    Bernhoft, Inger Marie; Hels, Tove; Simonsen, Kirsten Wiese

    2012-01-01

    Abstrakt Denne artikel omhandler forekomsten af alkohol, narkotika og medicin hos danske bilister, som er blevet alvorligt skadet i færdselsuheld. Undersøgelsen er baseret på anonyme blodprøver fra 840 førere af person- og varebiler, der blev indbragt til hospitalerne i Odense, Kolding, Vejle...... for undersøgelsen blev der desuden indhentet oplysning om patientens alder og køn, typen af køretøj, uheldsstedet, typen af færdselsuheld, tidspunkt for færdselsuheldet og prøvetagningen samt eventuel medicin, der var blevet givet før udtagning af blodprøven. Alkohol alene eller alkohol sammen med andre stoffer var...... for cannabis (2,3 %) efterfulgt af amfetamin (1,1 %). I alt var 41,6 % af de tilskadekomne i eneuheld positive for stoffer, heraf 30 % for alkohol alene eller alkohol sammen med andre stoffer. For bilister i flerpartsuheld var i alt 19 % positive, heraf knap 9 % for alkohol alene eller alkohol sammen med andre...

  13. Dannelsen af en psykologisk og videnskabelig habitus hos psykologistuderende

    DEFF Research Database (Denmark)

    Feilberg, Casper

    Dannelsen af en psykologisk og videnskabelig habitus hos psykologistuderende, Casper Feilberg Afhandlingen er en empirisk undersøgelse af psykologistuderendes tilegnelse af træk ved en psykologisk og videnskabelig habitus ved psykologistudierne på Roskilde Universitet og Aalborg Universitet. Herved...... bidrager afhandlingen til den overordnede diskussion om, hvad målet med og kvalitet i en universitetsuddannelse skal forstås som. Som udgangspunkt for studiet af psykologistuderendes dannelsesprocesser indføres en analytisk distinktion mellem en psykologisk habitus (fænomen orienteret), og en videnskabelig...... habitus (teoretisk/metodisk). Herved tydeliggøres de studerendes dobbelte opgave der består i, at man må lære at trække på sin egen livsverden på en kvalificeret måde, når man skal forstå andre (psykologisk habitus), men at denne psykologiske sans for problemstillingen også må opkvalificeres via...

  14. Trofiske skift og fysiske faktorer i væksten hos Færøske torsk (Gadus morhua) undersøgt ved brug af stabile isotoper

    DEFF Research Database (Denmark)

    Munk-Nielsen, Jens; Christensen, Jens Tang; Grønkjær, P.

    Projektets formål er at forstå variationen i vækst hos torsk (Gadus Morhua) ved brug af otolither (øresten), og sammenhængen med fysiske faktorer, såsom havstrømme, hav temperatur, osv på den Færøske shelf. Dette undersøges ved hjælp af, 1) en otolith vækst kronologi som dækker mere end 60 år (1948...... en mindre amplitude i variationen af ringbredde end direkte vækst målinger. Over hele vækstkronologien ses en negativ udvikling i væksten hos torsk, dog afbrudt af kortere perioder med positiv vækst. De stabile isotop prøver udtages fra hele otolitter fra 5 år gamle torsk. Fra protein delen af...... omgivelser torsken har oplevet, især den omgivende temperatur. Karbon signalet fra den uorganiske del af otolitten vil blive sammenlignet med værdierne i protein delen. De stabile isotop-værdier, samt vækst data vil blive analyseret for at se sammenhængen mellem klimaet og væksten hos torsk. Både lokalt, med...

  15. Overexpression of an orchid (Dendrobium nobile SOC1/TM3-like ortholog, DnAGL19, in Arabidopsis regulates HOS1-FT expression

    Directory of Open Access Journals (Sweden)

    Xiao-ru eLiu

    2016-02-01

    Full Text Available Flowering in the appropriate season is critical for successful reproduction in angiosperms. The orchid species, Dendrobium nobile, requires vernalization to achieve flowering in the spring, but the underlying regulatory network has not been identified to date. The MADS-box transcription factor DnAGL19 was previously identified in a study of low-temperature treated D. nobile buds and was suggested to regulate vernalization-induced flowering. In this study, phylogenetic analysis of DnAGL9 and the MADS-box containing proteins showed that DnAGL19 is phylogenetically closely related to the SOC1-like protein from orchid Dendrobium Chao Parya Smile, DOSOC1. The orchid clade closed to but is not included into the SOC1-1/TM3 clades associated with either eudicots or monocots, suggesting that DnAGL19 is an SOC1-1/TM3-like ortholog. DnAGL19 was found to be highly expressed in pseudobulbs, leaves, roots and axillary buds but rarely in flowers, and to be substantially upregulated in axillary buds by prolonged low-temperature treatments. Overexpression of DnAGL19 in Arabidopsis thaliana resulted in a small but significantly reduced time to bolting, suggesting that flowering time was slightly accelerated under normal growth conditions. Consistent with this, the A. thaliana APETELA1 (AP1 gene was expressed at an earlier stage in transgenic lines than in wild type plants, while the FLOWERING LOCUS T (FT gene was suppressed, suggesting that altered regulations on these transcription factors caused the weak promotion of flowering. HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 (HOS1 was slightly activated under the same conditions, suggesting that the HOS1-FT module may be involved in the DnAGL19-related network. Under vernalization conditions, FT expression was significantly upregulated, whereas HOS1 expression in the transgenic A. thaliana has a level similar to that in wild type. Taken together, these results suggest that DnAGL19 controls the action of the

  16. Når alderen indhenter én. Kropslighed, aldring og profession hos gymnasiets idrætslærere. Ph.d. afhandling

    DEFF Research Database (Denmark)

    Christensen, Mette Krogh

    Når alderen indhenter én – om kropslighed, aldring og profession hos gymnasiets idrætslærere er en ph.d.-afhandling udarbejdet af Mette Krogh Christensen på Institut for Idræt (Afdeling for Historie og Samfundsvidenskab), Københavns Universitet. Afhandlingen handler om, på hvilken måde alder spil...

  17. Læring i praksis. Tilrettelegging for å fremme refleksjonskompetanse og læringsutbytte hos studenter i praksis. Erfaringer fra en pilotstudie.

    Directory of Open Access Journals (Sweden)

    Kari Høium

    2009-02-01

    Full Text Available Studien belyser erfaringer med en tilpasset veiledningsmodell i gruppe, for å styrke profesjonell kompetanse hos vernepleiestudenter i praksis. Intervensjonen er gjennomført i forhold til 32 bachelorstudenter fra tre ulike kull. Den tar utgangspunkt i en obligatorisk veiledningsgruppe som foregår inne på høgskolen, midtveis i en av deres praksisperioder. Hovedmålsettingen var å se i hvilken grad veiledningsmodellen bidro til utbytte og læringseffekt i forhold til målsetting for praksisperioden. Et annet mål med studien har vært å skaffe erfaringer med hvordan refleksjon og kritisk tenkning kan læres gjennom praktisk student veiledning. Resultater fra undersøkelsen viste at den tilpassede veiledningsmodellen som her ble benyttet, bidro til å fremme refleksjonskompetanse og læringsutbytte hos studentene. Dette gir grunnlag for videre optimisme med tanke på å styrke vernepleiestudentenes læring og profesjonelle kompetanse. Betydningen forsterkes ved at refleksjonskompetanse fremheves som en sentral kvalitetsvariabel, både fra myndighetene og fra fagfeltet. En videre utfordring vil være å raffinere modellen ytterligere med tanke på utprøving og tilpasset implementering gjennom ulike praksisperioder i studiet.

  18. 15-åringers opplevelser av overvekt hos jevnaldrende, en fenomenologisk-hermeneutisk studie

    Directory of Open Access Journals (Sweden)

    Reidun Rognsaa

    2011-06-01

    Full Text Available Hensikten med denne studien er å studere hvordan 15-åringer opplever overvekt hos jevnaldrende. Datamaterialet består av dybdeintervju med syv ungdommer. Det er benyttet fenomenologisk-hermeneutisk analyse. Ungdommene opplever å stå i en posisjon mellom makt og avmakt. I denne mellomposisjonen framkommer det at ungdommene distanserer seg ved hjelp av relasjonell makt, men samtidig setter de seg selv i en avmaktssituasjon i forhold til ungdomskulturens spilleregler. Ungdommene moraliserer ved å skape en situasjon hvor de underkjenner overvektige, samtidig mangler de ytterligere sanksjoneringsmuligheter. Rangordninger skapes gjennom at ungdommene degraderer overvektige, men de må selv også innordne seg i egen kultur. Ungdommene fratar overvektige sitt menneskeverd gjennom å redusere menneskelige egenskaper og gjør dem til objekt. Gjennom denne objektiviseringen setter de seg selv utenfor det å få tak i overvektiges refleksjons- og erfaringsgrunnlag.

  19. Generel populationsscreening af mentalt helbred hos småbørn

    DEFF Research Database (Denmark)

    Ammitzbøll, Janni; Skovgaard, Anne Mette; Kreiner, Svend

    Psykiske vanskeligheder rammer mere end 10 % af børnepopulationen, og udgør de hyppigste årsager til sociale og helbredsmæssige problemer hos børn og unge. De fleste former for psykiske forstyrrelser opstår tidligt i livet, og intervention i førskolealderen vil kunne begrænse udviklingen af...... autismetilstande, adfærdsforstyrrelser og ADHD. Resultater fra det danske forløbsstudie CCC2000 har vist at mentale helbredsproblemer kan opspores ved sundhedsplejerskernes hjemmebesøg. Forudsætningen er, at der foreligger valide screeningsmetoder, hvilket der ikke gør i dag. Der findes således ikke validerede...... hyppighed i normalbefolkningen. Undersøgelsen viser at validiteten er høj og at PUF er egnet til populationsscreening. Analyser af den prædiktive validitet af PUF er i gang, og der er planlagt udvikling af en interventionsmetode, der kan kobles til PUF screeningen. Såfremt tidlig intervention baseret på PUF...

  20. Hälsofrämjande fysisk aktivitet hos personer under adjuvant cancerbehandling relaterad till fatigue, livskvalitet samt self-efficacy

    OpenAIRE

    Zetterlund, Johanna

    2016-01-01

    Bakgrund Cancerdrabbade lider ofta av cancerrelaterad fatigue (CRF) och försämrad livskvalitet under och efter behandling. Hälsofrämjande fysisk aktivitet (HFA) kan minska risken för dessa negativa konsekvenser. HFA påverkas bl.a. av träningsrelaterad self-efficacy, dvs tilltron till egen förmåga att vara fysisk aktiv. Syfte Att undersöka HFA hos personer under adjuvant cancerbehandling vid diagnos och efter sex månader samt att undersöka om de med en stabil HFA hade lägre CRF, högre livskval...

  1. Omvårdnadsåtgärder för att minska rädsla, oro och ångest hos barn 0-18 år i samband med en röntgenundersökning : En litteraturstudie

    OpenAIRE

    Mohsen, Nadja; Imsirovic, Amela

    2016-01-01

    Bakgrund: Att besöka en röntgenavdelning kan vara något nytt och skrämmande för många barn. Den nya miljön kan orsaka rädsla, oro och ångest hos barn. Därför är det viktigt att röntgensjuksköterskan har kunskap om barnets behov för att upplevelsen på röntgenavdelningen ska vara så bra som möjligt. Syfte: Syftet med den här studien är att beskriva omvårdnadsåtgärder för att minska rädsla, oro och ångest hos barn 0-18 år i samband med röntgenundersökning. Metod: Detta arbete är en litteraturstu...

  2. KR’PTA. Samtidspoesin och Derrida : Spår och ärrbildningar hos Johannes Heldén, Ingrid Storholmen och Anna Hallberg

    OpenAIRE

    Schmidt, Lisa

    2006-01-01

    Lisa Schmidt, KR’PTA. Samtidspoesin och Derrida. Spår och ärrbildningar hos Johannes Hel­dén, Ingrid Storholmen och Anna Hallberg. (CR’PT. Contemporary Poetry and Derrida: Traces and Scarring in the Poetry of Johannes Heldén, Ingrid Storholmen and Anna Hallberg.) Through the analyses of three contemporary Nordic poets whose work challenges the boun­daries of literature and even the laws of grammar, I draw attention to the term linguistic materialism. I also sketch an historical line between t...

  3. NRDA-processed CTD data from the HOS Davis in the Gulf of Mexico, Cruise 3 Leg 1, collected from 2010-09-09 to 2010-09-27, associated with the Deepwater Horizon Oil Spill event (NCEI Accession 0130017)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Conductivity Temperature and Depth (CTD) measurements were collected aboard the R/V HOS Davis, Cruise 03, to determine physical oceanographic parameters of the water...

  4. NRDA-processed CTD data from the HOS Davis in the Gulf of Mexico, Cruise 1 Leg 1, collected from 2010-08-13 to 2010-08-22, associated with the Deepwater Horizon Oil Spill event (NCEI Accession 0128072)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Conductivity Temperature and Depth (CTD) measurements were collected aboard the R/V HOS Davis, Cruise 01, to determine physical oceanographic parameters of the water...

  5. NRDA-processed CTD data from the HOS Davis in the Gulf of Mexico, Cruise 4 Leg 1, collected from 2010-11-07 to 2010-11-14, associated with the Deepwater Horizon Oil Spill event (NCEI Accession 0130023)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Conductivity Temperature and Depth (CTD) measurements were collected aboard the R/V HOS Davis, Cruise 04, to determine physical oceanographic parameters of the water...

  6. NRDA-processed CTD data from the HOS Davis in the Gulf of Mexico, Cruise 2 Leg 1, collected from 2010-08-26 to 2010-09-02, associated with the Deepwater Horizon Oil Spill event (NCEI Accession 0128093)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Conductivity Temperature and Depth (CTD) measurements were collected aboard the R/V HOS Davis, Cruise 02, to determine physical oceanographic parameters of the water...

  7. Chemical and physical oceanographic profile data collected from CTD casts aboard the HOS Davis in the Gulf of Mexico from 2010-08-26 to 2010-09-03 in response to the Deepwater Horizon oil spill event (NODC Accession 0069070)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical and physical oceanographic profile data were collected aboard the HOS Davis in the Gulf of Mexico from 2010-08-26 to 2010-09-03 in response to the Deepwater...

  8. Chemical and physical oceanographic profile data collected from CTD casts aboard the HOS Davis in the Gulf of Mexico from 2010-09-09 to 2010-09-27 in response to the Deepwater Horizon oil spill event (NODC Accession 0069071)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical and physical oceanographic profile data were collected aboard the HOS Davis in the Gulf of Mexico from 2010-09-09 to 2010-09-27 in response to the Deepwater...

  9. Chemical and physical oceanographic profile data collected from CTD casts aboard the HOS Davis in the Gulf of Mexico from 2010-08-13 to 2010-08-22 in response to the Deepwater Horizon oil spill event (NODC Accession 0069069)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical and physical oceanographic profile data were collected aboard the HOS Davis in the Gulf of Mexico from 2010-08-13 to 2010-08-22 in response to the Deepwater...

  10. A HOS-based blind deconvolution algorithm for the improvement of time resolution of mixed phase low SNR seismic data

    International Nuclear Information System (INIS)

    Hani, Ahmad Fadzil M; Younis, M Shahzad; Halim, M Firdaus M

    2009-01-01

    A blind deconvolution technique using a modified higher order statistics (HOS)-based eigenvector algorithm (EVA) is presented in this paper. The main purpose of the technique is to enable the processing of low SNR short length seismograms. In our study, the seismogram is assumed to be the output of a mixed phase source wavelet (system) driven by a non-Gaussian input signal (due to earth) with additive Gaussian noise. Techniques based on second-order statistics are shown to fail when processing non-minimum phase seismic signals because they only rely on the autocorrelation function of the observed signal. In contrast, existing HOS-based blind deconvolution techniques are suitable in the processing of a non-minimum (mixed) phase system; however, most of them are unable to converge and show poor performance whenever noise dominates the actual signal, especially in the cases where the observed data are limited (few samples). The developed blind equalization technique is primarily based on the EVA for blind equalization, initially to deal with mixed phase non-Gaussian seismic signals. In order to deal with the dominant noise issue and small number of available samples, certain modifications are incorporated into the EVA. For determining the deconvolution filter, one of the modifications is to use more than one higher order cumulant slice in the EVA. This overcomes the possibility of non-convergence due to a low signal-to-noise ratio (SNR) of the observed signal. The other modification conditions the cumulant slice by increasing the power of eigenvalues of the cumulant slice, related to actual signal, and rejects the eigenvalues below the threshold representing the noise. This modification reduces the effect of the availability of a small number of samples and strong additive noise on the cumulant slices. These modifications are found to improve the overall deconvolution performance, with approximately a five-fold reduction in a mean square error (MSE) and a six

  11. Familjearbetaren hos en ensamförsörjare : en kvalitativ studie om ensamförsörjarens livssituation och hur familjearbetet påverkas

    OpenAIRE

    Sjöblom, Mikaela; Azimi, Diana

    2013-01-01

    Syftet med vårt lärdomsprov är att redogöra för familjearbetarnas åsikter om familjearbetet har specifika drag i utförandet av det hos familjer med en försörjare. I teoridelen tas det upp om familjepolitiken i Finland, familjearbete samt om hur en ensamförsörjares livssituation kan se ut. I undersökningen använde vi oss av kvalitativa forskningsintervjuer. Undersökningspersonerna bestod av åtta familjearbetare från fyra olika kommuner. Intervjuerna gjordes både i grupper och som individue...

  12. Hvordan kan utfordringer føre til økt læring og utvikling hos fremtidige elite fotballspillere og elitesoldater?: et komparativt casestudie mellom Forsvarets Spesialkommando og en fotballklubb i eliteserien

    OpenAIRE

    Nilsen, Kim-André

    2015-01-01

    Masteroppgave - Norges idrettshøgskole, 2015 I dette prosjektet ønsket jeg å finne ut hvordan motgang og utfordringer kan føre til økt læring og utvikling hos fremtidige elitesoldater og fotballspillere på elitenivå. Dette er en komparativ casestudie mellom en fotballklubb i eliteserien og Forsvarets Spesialkommando (FSK). I denne beskrivende casestudien ble semi-strukturerte intervjuer og dokumentasjonsundersøkelser benyttet i datainnsamlingen. I forbindelse med rekrutterin...

  13. Høyintensiv aerob intervalltrening utført som ekstrembolk fører ikke til endringer i VO2max hos elitesyklister og ??riatleter

    OpenAIRE

    Pedersen, Frank-Gøran

    2014-01-01

    HENSIKT: Studien hadde til hensikt å undersøke virkningen av høyintensiv aerob intervalltrening (HAIT) på maksimalt oksygenopptak (VO2max) og tid på Time trial (TT) hos elitesyklister og triatleter. METODE: 11 forsøkspersoner, n=7 HAIT (31±9) og n=4 kontroll (27±11), VO2max HAIT 62.6±6.4, VO2max 65.6±5.7 gjennomførte denne studien. HAIT gjennomførte 14 intervalløkter (4x4 løpeintervaller på tredemølle, 3-5%stigning, 90-95% av Hfmax, 3 minutter aktiv hvile på ca. 70% av Hfmax) over ti dager,et...

  14. Betydningen af Lawsonia og PCV2 virus for daglig tilvækst hos slagtesvin

    DEFF Research Database (Denmark)

    Johansen, Markku; Nielsen, Mai Britt Friis; Dahl, Jan

    Resultaterne af denne undersøgelse viser at: - Grise med store mængder Lawsonia i gødningen (≥106/gram gødning) har større risiko (OR=5,2) for at være en langsomt voksende gris. - Grise med synlige tarmforandringer har større risiko (OR=13,2) for at være en langsomt voksende gris. - Grise med...... diarré har større risiko (OR=10,1) for at være en langsomt voksende gris. Derimod kunne der ikke påvises nogen sammenhæng mellem mængden af PCV2 virus, antistoffer mod PCV2 virus eller påvisning af PCV2 virus ved immunhistokemi i tarmlymfeknude og tilvæksten hos grise. Undersøgelsen er gennemført i 5...... virus og Lawsonia på DTU-Veterinærinstitutet. For hver gris blev den maksimalt målte værdi af Lawsonia og PCV2 virus mængde i gødning og antistoffer mod de to sygdomme brugt som forklarende variabel. Sammenhængen til hurtigt/langsomt voksende grise for de maksimalt målte værdier blev undersøgt ved...

  15. Sambandet mellan Theory of Mind, språkliga förmågor och exekutiva funktioner hos barn i treårsåldern

    OpenAIRE

    Nilsson, Anna; Sirén, Ellen

    2015-01-01

    Barns fem första levnadsår präglas av en omfattande utveckling av språkliga förmågor och exekutiva funktioner, vilka är färdigheter som visat sig ha en stor påverkan på hur barn utvecklar förståelse för sina egna och andras tankar, det vill säga deras Theory of Mind. En central aspekt inom forskning har varit att undersöka hur förmågorna samvarierar vid olika åldrar. Syftet i föreliggande studie var att undersöka sambandet mellan Theory of Mind, språkliga förmågor och exekutiva funktioner hos...

  16. Dömda att leva i skuggan : En kvalitativ intervjustudie om hälsan hos personer med albinism i Rwanda, utifrån begreppen diskriminering, coping och socialt stöd

    OpenAIRE

    Niyonkuru, Elsie Diane

    2016-01-01

    Bakgrund: Oculocutaneous albinism (OCA) är en ärftlig sjukdom som fysiskt, psykiskt och socialt påverkar de drabbade individerna. Okunskap, fördomar och myter om albinism utgör de största orsakerna till den diskriminering som personer med albinism utsatts för särskilt i vissa länder i Afrika söder om Sahara. Syfte: Syftet är att beskriva hälsan hos personer med albinism i Rwanda, utifrån begreppen diskriminering, coping och socialt stöd. Metod: En kvalitativ metod med induktiv ansats ligger t...

  17. Identitetshantering på Facebook : En kvalitativ studie om förhållningssättet till den egna identiteten hos två olika åldersgrupper på vår tids mest offentliga scen

    OpenAIRE

    Kåge, Isabelle

    2010-01-01

    Title: Identity management on Facebook: a qualitative study in approaches to personal identity between two different age groups on the most public stage of our time (Identitetshantering på Facebook: En kvalitativ studie om förhållningssättet till den egna identiteten hos två olika åldersgrupper på vår tids mest offentliga scen). Number of pages: 43. Author: Isabelle Kåge. Tutor: Amelie Hössjer. Course: Media and Communication Studies C. Period: Fall Semester 2010. University: Division of Medi...

  18. Clarté des idées innées ?

    DEFF Research Database (Denmark)

    Schøsler, Jørn

    2013-01-01

    Der gives en analyse af begreberne 'evidens' og 'medfødte idéer' hos Descartes og Locke samt hos de franske oplysningsfilosoffer.......Der gives en analyse af begreberne 'evidens' og 'medfødte idéer' hos Descartes og Locke samt hos de franske oplysningsfilosoffer....

  19. Perceptions About the Present and Future of Surgical Simulation: A National Study of Mixed Qualitative and Quantitative Methodology.

    Science.gov (United States)

    Yiasemidou, Marina; Glassman, Daniel; Tomlinson, James; Song, David; Gough, Michael J

    Assess expert opinion on the current and future role of simulation in surgical education. Expert opinion was sought through an externally validated questionnaire that was disseminated electronically. Heads of Schools of Surgery (HoS) (and deputies) and Training Program Directors (TPD) (and deputies). Simulation was considered a good training tool (HoS: 15/15, TPD: 21/21). The concept that simulation is useful mostly to novices and for basic skills acquisition was rejected (HoS: 15/15, TPDs: 21/21; HoS: 13/15, TPDs: 18/21). Further, simulation is considered suitable for teaching nontechnical skills (HoS: 13/15, TPDs: 20/21) and re-enacting stressful situations (HoS: 14/15, TPDs: 15/21). Most respondents also felt that education centers should be formally accredited (HoS: 12/15, TPDs: 16/21) and that consultant mentors should be appointed by every trust (HoS: 12/15, TPDs: 19/21). In contrast, there were mixed views on its use for trainee assessment (HoS: 6/15, TPDs: 14/21) and whether it should be compulsory (HoS: 8/15, TPDs: 11/21). The use of simulation for the acquirement of both technical and nontechnical skills is strongly supported while views on other applications (e.g., assessment) are conflicting. Further, the need for center accreditation and supervised, consultant-led teaching is highlighted. Copyright © 2016 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  20. Potential use of hyperoxygenated solution as a treatment strategy for carbon monoxide poisoning.

    Directory of Open Access Journals (Sweden)

    Xingxing Sun

    Full Text Available AIM: Carbon monoxide (CO poisoning can cause permanent damage in tissues that are sensitive to hypoxia. We explored the feasibility and efficacy of using a hyperoxygenated solution (HOS to treat severe acute CO poisoning in an animal model. METHODS: Male Sprague-Dawley rats were subjected to CO poisoning. The HOS was administered into the femoral vein of these rats through a catheter (10 ml/kg. Carboxyhemoglobin (COHb and blood gases were used to assess the early damage caused by CO poisoning. S100β was measured to predict the development of late cognitive sequelae of CO. The Morris water maze test was performed to assess cognitive function, and Nissl staining was performed to observe histologic change. RESULTS: The COHb concentrations rapidly decreased at 5 min after the HOS administration; however, the PaO2 and SaO2 in rats treated with HOS increased significantly 5 min after the HOS administration. The S100β concentrations, which increased significantly after CO poisoning, increased at a much slower rate in the rats treated with HOS (HOS group compared with the rats treated with O2 inhalation (O2 group. The escape latency in the place navigation test was shortened after CO poisoning on days 11-15 and days 26-30, and the swimming time in quadrant 4 in the spatial probe test on days 15 and 30 after CO poisoning was prolonged in the rats treated with HOS injection compared with the rats treated with oxygen inhalation or normal saline injection. The neuronal degeneration in the HOS group was alleviated than that in the CO or O2 group. CONCLUSION: HOS efficiently alleviates the brain damage in acute CO-poisoned rats and thus may serve as a new way to treat human patients with CO poisoning in clinical practice.

  1. History of science content analysis of Chinese science textbooks from the perspective of acculturation

    Science.gov (United States)

    Ma, Yongjun; Wan, Yanlan

    2017-08-01

    Based on previous international studies, a content analysis scheme has been designed and used from the perspective of culture to study the history of science (HOS) in science textbooks. Nineteen sets of Chinese science textbooks have been analyzed. It has been found that there are noticeable changes in the quantity, content, layout, presentation, and writing intention of the HOS sections in textbooks from different time periods. What's more, the textbooks aim at presenting the scientific culture and aim to help students understand it better. However, the cultural associations of the HOS in textbooks is insufficient and significant differences exist among textbooks of different subjects. In order to explore the reasons why the presentation of HOS in various subjects is different, we made a specific comparison of curriculum standards of two subjects with great differences and interviewed the editors-in-chief of two textbooks. Results show that one of the most important reasons for the different writings of the HOS in textbooks is that different subject curriculum standards attach greater importance to the HOS. In addition, the attention to the HOS by editors-in-chief, the tradition of studying the HOS within the history of the discipline, and the reference textbooks in compiling textbooks are all important influence factors. Some suggestions for future textbooks compilation are given at the end.

  2. Ny Mycoplasma Hyosynoviae vaccine forebygger ikke halthed

    DEFF Research Database (Denmark)

    Nielsen, Elisabeth Okholm; Lauritsen, Klara Tølbøll; Jungersen, Gregers

    Vaccination af smågrise mod Mykoplasma-ledbetændelser viste sig ikke at kunne forebyggede halthed hos slagtesvin. Smitte med Mycoplasma hyosynoviae (M. hyosynoviae) er ofte årsag til ledbetændelse hos slagtesvin. Der er ingen kommerciel vaccine til grise, der beskytter mod mykoplasma-ledbetændels......Vaccination af smågrise mod Mykoplasma-ledbetændelser viste sig ikke at kunne forebyggede halthed hos slagtesvin. Smitte med Mycoplasma hyosynoviae (M. hyosynoviae) er ofte årsag til ledbetændelse hos slagtesvin. Der er ingen kommerciel vaccine til grise, der beskytter mod mykoplasma...

  3. Should We Add History of Science to Provide Nature of Science into Vietnamese Biology Textbook: A Case of Evolution and Genetics Teaching?

    Science.gov (United States)

    Diem, Huynh Thi Thuy; Yuenyong, Chokchai

    2018-01-01

    History of science (HOS) plays a substantial role in the enhancement of rooted understanding in science teaching and learning. HOS of evolution and genetics has not been included in Vietnamese biology textbooks. This study aims to investigate the necessity of introducing evolution and genetics HOS into Vietnamese textbooks. A case study approach…

  4. Hip Arthroscopy Outcomes With Respect to Patient Acceptable Symptomatic State and Minimal Clinically Important Difference.

    Science.gov (United States)

    Levy, David M; Kuhns, Benjamin D; Chahal, Jaskarndip; Philippon, Marc J; Kelly, Bryan T; Nho, Shane J

    2016-09-01

    To determine whether the hip arthroscopy literature to date has shown outcomes consistent with published patient acceptable symptomatic state (PASS) and minimal clinically important difference (MCID) estimates. All clinical investigations of hip arthroscopy using modified Harris Hip Score (mHHS) and/or Hip Outcome Score (HOS) outcomes with at least 1 year of follow-up were reviewed. Ninety-one studies (9,746 hips) were included for review. Eighty-one studies (9,317 hips) contained only primary hip arthroscopies and were the primary focus of this review. The remaining studies (429 hips) did not exclude patients with prior surgical history and were thus considered separately. Mean mHHS, HOS-ADL (Activities of Daily Living) and HOS-SS (Sports-Specific) scores were compared with previously published PASS and MCID values. After 31 ± 20 months, 5.8% of study populations required revision arthroscopy and 5.5% total hip arthroplasty. A total of 88%, 25%, and 30% of study populations met PASS for mHHS, HOS-ADL, and HOS-SS, respectively, and 97%, 90%, and 93% met MCID. On bivariate analysis, increasing age was associated with significantly worse postoperative mHHS (P arthroscopy, we have found that more than 90% of study populations meet MCID standards for the most commonly used patient-reported outcomes measures in hip arthroscopy literature, mHHS and HOS. Eighty-eight percent meet PASS standards for the mHHS, but PASS standards are far more difficult to achieve for HOS-ADL (25%) and HOS-SS (30%) subscales. Differences in psychometric properties of the mHHS and HOS likely account for the discrepancies in PASS. Level IV, systematic review of Level I to IV studies. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  5. Hospitalization is less in malnourished patients given intradialytic oral nutritional supplements

    Directory of Open Access Journals (Sweden)

    Eduardo Lacson Jr.

    2012-06-01

    Overall, HOS was lower in the ONS group (N= 7,264 at 2.5 vs. 2.7 episodes/pt‐year for controls (N= 13,853, p<0.001. The unadjusted time to 1st HOS hazard ratio for ONS was 0.92 (0.88, 0.95 and after adjustment for baseline case‐mix, HOS 30‐days prior to study entry, and 5 HD quality indicators was 0.93 (0.90, 0.96. Although limited by the observational design, these results indicate lower HOS associated with ONS use in malnourished chronic HD patients with albumin ≤3.5 g/dL.

  6. The Medicare Health Outcomes Survey program: Overview, context, and near-term prospects

    Directory of Open Access Journals (Sweden)

    Miller Nancy A

    2004-07-01

    Full Text Available Abstract In 1996, the Centers for Medicare & Medicaid Services (CMS initiated the development of the Medicare Health Outcomes Survey (HOS. It is the first national survey to measure the quality of life and functional health status of Medicare beneficiaries enrolled in managed care. The program seeks to gather valid and reliable health status data in Medicare managed care for use in quality improvement activities, public reporting, plan accountability and improving health outcomes based on competition. The context that led to the development of the HOS was formed by the convergence of the following factors: 1 a recognized need to monitor the performance of managed care plans, 2 technical expertise and advancement in the areas of quality measurement and health outcomes assessment, 3 the existence of a tested functional health status assessment tool (SF-36®1, which was valid for an elderly population, 4 CMS leadership, and 5 political interest in quality improvement. Since 1998, there have been six baseline surveys and four follow up surveys. CMS, working with its partners, performs the following tasks as part of the HOS program: 1 Supports the technical/scientific development of the HOS measure, 2 Certifies survey vendors, 3 Collects Health Plan Employer Data and Information Set(HEDIS®2 HOS data, 4 Cleans, scores, and disseminates annual rounds of HOS data, public use files and reports to CMS, Quality Improvement Organizations (QIOs, Medicare+Choice Organizations (M+COs, and other stakeholders, 5 Trains M+COs and QIOs in the use of functional status measures and best practices for improving care, 6 Provides technical assistance to CMS, QIOs, M+COs and other data users, and 7 Conducts analyses using HOS data to support CMS and HHS priorities. CMS has recently sponsored an evaluation of the HOS program, which will provide the information necessary to enhance the future administration of the program. Information collected to date reveals that the

  7. Psychometric Evaluation of the Lower Extremity Computerized Adaptive Test, the Modified Harris Hip Score, and the Hip Outcome Score.

    Science.gov (United States)

    Hung, Man; Hon, Shirley D; Cheng, Christine; Franklin, Jeremy D; Aoki, Stephen K; Anderson, Mike B; Kapron, Ashley L; Peters, Christopher L; Pelt, Christopher E

    2014-12-01

    The applicability and validity of many patient-reported outcome measures in the high-functioning population are not well understood. To compare the psychometric properties of the modified Harris Hip Score (mHHS), the Hip Outcome Score activities of daily living subscale (HOS-ADL) and sports (HOS-sports), and the Lower Extremity Computerized Adaptive Test (LE CAT). The hypotheses was that all instruments would perform well but that the LE CAT would show superiority psychometrically because a combination of CAT and a large item bank allows for a high degree of measurement precision. Cohort study (diagnosis); Level of evidence, 2. Data were collected from 472 advanced-age, active participants from the Huntsman World Senior Games in 2012. Validity evidences were examined through item fit, dimensionality, monotonicity, local independence, differential item functioning, person raw score to measure correlation, and instrument coverage (ie, ceiling and floor effects), and reliability evidences were examined through Cronbach alpha and person separation index. All instruments demonstrated good item fit, unidimensionality, monotonicity, local independence, and person raw score to measure correlations. The HOS-ADL had high ceiling effects of 36.02%, and the mHHS had ceiling effects of 27.54%. The LE CAT had ceiling effects of 8.47%, and the HOS-sports had no ceiling effects. None of the instruments had any floor effects. The mHHS had a very low Cronbach alpha of 0.41 and an extremely low person separation index of 0.08. Reliabilities for the LE CAT were excellent and for the HOS-ADL and HOS-sports were good. The LE CAT showed better psychometric properties overall than the HOS-ADL, HOS-sports, and mHHS for the senior population. The mHHS demonstrated pronounced ceiling effects and poor reliabilities that should be of concern. The high ceiling effects for the HOS-ADL were also of concern. The LE CAT was superior in all psychometric aspects examined in this study. Future

  8. Elaphostrongylus spp. from Scandinavian cervidae - a scanning electron microscope study (SEM

    Directory of Open Access Journals (Sweden)

    Margareta Stéen

    1990-08-01

    Full Text Available Nematodes of the genus Elaphostrongylus collected from moose (Alces alces L., reindeer (Rangifer tarandus tarandus L., and red deer (Cervus elaphus L., respectively, were studied by means of scanning electron microscopy. Morphological differences in the ribs of the genital bursa were demonstrated. The Elaphostrongylus species from reindeer and red deer differed from each other in four ribs of the genital bursa. These results agree with the morphological characters of E. cervi and E. rangiferi described by Cameron (1931 and Mitskevitch (1960. The genital bursa of Elaphostrongylus sp. from moose, in accordance with the description of E. alces by Steen et al. (1989 showed characteristics differing from those found in Elaphostrongylus spp. from reindeer and red deer respectively. These results support the hypothesis that there are three separate species of Elaphostrongylus present in Scandinavian Cervidae. Svep-elektroniska studier på Elaphostrongylus spp. hos skandinaviska hjortdjur.Abstract in Swedish / Sammandrag: Rundmaskar inom slaktet Elaphostrongylus funna hos alg (Alces alces L., ren (Rangifer tarandus tarandus L. och kronhjort(Cervus elaphus L. studerades med hjalp av svepelelektronmikroskop. De hanliga bursorna med sin a stodjeribbor uppvisade variationer i utseende, langd och placering mellan dessa rundmaskar. De arter av Elaphostrongylus funna hos ren och kronhjort skilde sig åt avseende fyra stodjeribbor på de hanliga bursorna. Dessa resultat stammer val overens med de karaktarer som tidigare ar beskrivna av Cameron(1931 och av Mitskevich (1960. Den hanliga bursan hos arten Elaphostrongylus funnen hos alg, vilken tidigare ar beskriven av Steen et al. (1989, visade upp ett utseende som skilde sig från bursorna hos de Elaphostrongylus-arter funna hos ren och kronhjort. Dessa resultat stoder hypotesen om tre skilda arter av Elaphostrongylus hos skandinaviska hjortdjur.

  9. Cerebral blood flow autoregulation in patients with acute bacterial meningitis

    DEFF Research Database (Denmark)

    Møller, Kirsten

    2001-01-01

    Ph.d. afhandlingen omhandler sammenhængen mellem hjernens blodtilførsel (CBF) og middelarterietrykket (MAP) hos patienter med akut bakteriel meningitis. Hos raske er CBF uafhængig af MAP, hvilket kaldes CBF autoregulation. Svækket autoregulation antages at øge risikoen for cerebral hypoperfusion og...... iskæmi under episoder med lavt MAP, og for cerebral hyperperfusion og vasogent ødem ved højt MAP. CBF autoregulationen undersøgtes hos tyve voksne patienter med akut bakteriel meningitis i den tidlige sygdomsfase (... meningitis, men retableres ved klinisk restitution. Autoregulationen kan endvidere delvis retableres ved akut hyperventilation. Fundene har potentiel betydning for valg af supportiv terapi hos patienter med meningitis....

  10. How Do We Measure Success in Homelessness Services? : Critically Assessing the Rise of the Homelessness Outcomes Star

    OpenAIRE

    Johnson, Guy; Pleace, Nicholas

    2016-01-01

    The Homelessness Outcomes Star (HOS) is probably the most widespread form of outcome measurement employed by homelessness service providers. Developed in the UK, the HOS is now being used by homelessness services in other European countries and Australia, while being promoted internationally as a validated set of key performance indicators. This paper examines the ideological framework that underpins the HOS, as well as the theoretical and methodological approaches that inform its operation. ...

  11. EFEKTIFITAS HARD DAN SOFT OCCLUSAL SPLINT PADA GANGGUAN SENDI TEMPOROMANDIBULA (Kajian klinis pada seri kasus berdasarkan keluhan nyeri sendi temporomandibula

    Directory of Open Access Journals (Sweden)

    R.A Donna Pratiwi

    2015-08-01

    Full Text Available Occlusal splint is commonly used for treatment of the temporomandibular joint disorder (TMD. It can be made of hard and soft material. Hard occlusal splint (HOS which was known earlier had been recognized more effective than soft occlusal splint (SOS which recently gained some popularity. This clinical study based on case series was to determined which type of occlusal splint was more effective for TMD. This study involved 20 subjects and they were divided into HOS and SOS group with 10 subjects in each group. HOS was processed with heat curing acrylic and SOS with vacuum former. Before and after 4 weeks of treatment, 5 TMD symptoms (impaired range of movement, impaired TMJ function, muscle pain, TMJ pain and pain on movement of mandible were measured using Helkimo diagnostic index. The results were analyzed with Kolmogorov-Smirnov Z's test. The findings showed statistically significant improvement in impaired range of movement and muscle pain in favor of HOS group (p<0.05. Although they were not statistically significant, HOS group showed better improvement than SOS group in TMJ pain and pain on movement of the mandible. In TMJ's function, no changes were found in both groups. IN general, HOS was more effective than SOS for treating TMD in relatively short period of time. Despite of the phenomena, the popularity of SOS was not followed with its effectiveness.

  12. What motivates young physicians? - a qualitative analysis of the learning climate in specialist medical training.

    Science.gov (United States)

    Iblher, Peter; Hofmann, Marzellus; Zupanic, Michaela; Breuer, Georg

    2015-10-15

    Not least the much-invoked shortage of physicians in the current and the next generation has resulted in a wide range of efforts to improve postgraduate medical training. This is also in the focus of the current healthcare policy debate. Furthermore, quality and scope of available postgraduate training are important locational advantages in the competition for medical doctors. This study investigates the preferences and concerns that German house officers (HOs) have about their current postgraduate training. It also highlights how HOs evaluate the quality of their current postgraduate training and the learning environment. HOs were asked to answer the question: "Which things are of capital importance to you personally in your medical training?", using a free text format. The survey was conducted web based (Lime survey) and all data was anonymized. Summarizing qualitative analyses were performed using the software tool MaxQDA. A total of 255 HOs participated in this study (female: n = 129/50.6 %; male: n = 126/49.4 %; age: 32 + 6 years) associated with 17 different German hospitals and from four medical specialties. Ten categories were generated from a total of 366 free text answers: 1. methodology of learning (n = 66), 2. supervision (n = 66), 3. learning structure (n = 61), 4. teaching competence (n = 37), 5. dedication (n = 34), 6. work climate (n = 29), 7. feedback/communication (n = 22), 8. challenge/patient safety (n = 21), 9. time/resources (n = 17), 10. personal security/safety (n = 13). HOs want a reliable and curriculum-guided learning structure. Different studying techniques should be used with sufficient (time) resources available in a trusting and communicative learning environment. Competent and dedicated instructors are expected to give individual and specific feedback to the HOs on individual strengths and deficits. Instructors should develop educational concepts in cooperation with the HOs and

  13. Självkänsla hos daghemsbarn : En kvalitativ undersökning om hur barnträdgårdslärare bekräftar och stärker barnets självkänsla på daghem

    OpenAIRE

    Fant, Sofia

    2017-01-01

    Syftet med detta examensarbete är att ta reda på hur en barnträdgårdslärare kan stärka och bekräfta barnets självkänsla på daghem. Vilken syn och uppfattning finns det om självkänslan på daghem och hur kan man stödja barnen på bästa sätt när det gäller självkänslan? I detta examensarbete har jag genom litteratur tagit fram vad självkänsla är, men även olika definitioner kring självkänslan och hur miljön runt om kan påverka självkänslan hos barnet. I intervjuerna som blev gjorda framkom ...

  14. Undervisertip: Giv tid!

    DEFF Research Database (Denmark)

    Jakobsen, Uffe Lindberg Wewer

    2017-01-01

    Blogindlæg på LinkedIn om fordelene ved at øge refleksionstiden hos studerende i klasserumsundervisning.......Blogindlæg på LinkedIn om fordelene ved at øge refleksionstiden hos studerende i klasserumsundervisning....

  15. Mammary remodelling and metabolic activity in dairy goats:role of parity, dry period and nutrient supply

    OpenAIRE

    Safayi, Sina

    2009-01-01

    Mælkeproduktionen er generelt lav, men det er set at laktation persistensen er højere hos primiparous (PP) end hos multiparous (MP) drøvtyggere. Dette kan være relateret til forskelle i udvikling og opretholdelse af mælkekirtlernes funktion i yveret, dog er de underliggende mekanismer for dette er ikke klarlagt. Endvidere er mælkeproduktionen hos MP drøvtyggere ikke kun bestemt af dyrets genetiske ydeevne, men også af management strategier for varigheden af goldperioden og perioden omkring ny...

  16. A KH-Domain RNA-Binding Protein Interacts with FIERY2/CTD Phosphatase-Like 1 and Splicing Factors and Is Important for Pre-mRNA Splicing in Arabidopsis

    KAUST Repository

    Chen, Tao; Cui, Peng; Chen, Hao; Ali, Shahjahan; Zhang, ShouDong; Xiong, Liming

    2013-01-01

    Eukaryotic genomes encode hundreds of RNA-binding proteins, yet the functions of most of these proteins are unknown. In a genetic study of stress signal transduction in Arabidopsis, we identified a K homology (KH)-domain RNA-binding protein, HOS5 (High Osmotic Stress Gene Expression 5), as required for stress gene regulation and stress tolerance. HOS5 was found to interact with FIERY2/RNA polymerase II (RNAP II) carboxyl terminal domain (CTD) phosphatase-like 1 (FRY2/CPL1) both in vitro and in vivo. This interaction is mediated by the first double-stranded RNA-binding domain of FRY2/CPL1 and the KH domains of HOS5. Interestingly, both HOS5 and FRY2/CPL1 also interact with two novel serine-arginine (SR)-rich splicing factors, RS40 and RS41, in nuclear speckles. Importantly, FRY2/CPL1 is required for the recruitment of HOS5. In fry2 mutants, HOS5 failed to be localized in nuclear speckles but was found mainly in the nucleoplasm. hos5 mutants were impaired in mRNA export and accumulated a significant amount of mRNA in the nuclei, particularly under salt stress conditions. Arabidopsis mutants of all these genes exhibit similar stress-sensitive phenotypes. RNA-seq analyses of these mutants detected significant intron retention in many stress-related genes under salt stress but not under normal conditions. Our study not only identified several novel regulators of pre-mRNA processing as important for plant stress response but also suggested that, in addition to RNAP II CTD that is a well-recognized platform for the recruitment of mRNA processing factors, FRY2/CPL1 may also recruit specific factors to regulate the co-transcriptional processing of certain transcripts to deal with environmental challenges. © 2013 Chen et al.

  17. A KH-Domain RNA-Binding Protein Interacts with FIERY2/CTD Phosphatase-Like 1 and Splicing Factors and Is Important for Pre-mRNA Splicing in Arabidopsis

    KAUST Repository

    Chen, Tao

    2013-10-17

    Eukaryotic genomes encode hundreds of RNA-binding proteins, yet the functions of most of these proteins are unknown. In a genetic study of stress signal transduction in Arabidopsis, we identified a K homology (KH)-domain RNA-binding protein, HOS5 (High Osmotic Stress Gene Expression 5), as required for stress gene regulation and stress tolerance. HOS5 was found to interact with FIERY2/RNA polymerase II (RNAP II) carboxyl terminal domain (CTD) phosphatase-like 1 (FRY2/CPL1) both in vitro and in vivo. This interaction is mediated by the first double-stranded RNA-binding domain of FRY2/CPL1 and the KH domains of HOS5. Interestingly, both HOS5 and FRY2/CPL1 also interact with two novel serine-arginine (SR)-rich splicing factors, RS40 and RS41, in nuclear speckles. Importantly, FRY2/CPL1 is required for the recruitment of HOS5. In fry2 mutants, HOS5 failed to be localized in nuclear speckles but was found mainly in the nucleoplasm. hos5 mutants were impaired in mRNA export and accumulated a significant amount of mRNA in the nuclei, particularly under salt stress conditions. Arabidopsis mutants of all these genes exhibit similar stress-sensitive phenotypes. RNA-seq analyses of these mutants detected significant intron retention in many stress-related genes under salt stress but not under normal conditions. Our study not only identified several novel regulators of pre-mRNA processing as important for plant stress response but also suggested that, in addition to RNAP II CTD that is a well-recognized platform for the recruitment of mRNA processing factors, FRY2/CPL1 may also recruit specific factors to regulate the co-transcriptional processing of certain transcripts to deal with environmental challenges. © 2013 Chen et al.

  18. Individuell variasjon i utskillelse av 6-sulfatoksymelatonin og døgnrytmetype analysert hos skiftarbeidere

    Directory of Open Access Journals (Sweden)

    Tore Tynes

    2009-10-01

    Full Text Available  SAMMENDRAGI denne studien har vi undersøkt om det finnes noen sammenheng mellom målte verdier av urinmetabolitten6-sulfatoxymelatonin (aMT6s tatt ut i porsjoner gjennom døgnet og selvrapportert døgnrytme hos engruppe norske skiftarbeidere. Studien omfatter 19 arbeidstakere ved to produksjonsenheter ved HydroPorsgrunn, magnesiumfabrikken og fullgjødselfabrikk 3. Etter å ha deltatt i en studie der urinprøver blesamlet inn, svarte de involverte senere på et spørreskjema om søvn og døgnrytme. Resultatene indikerer ategenrapporterte B-type mennesker har en tendens til høyere midlere timeutskillelse av aMT6s analysert pådøgnbasis første døgn med nattskift, og en signifikant høyere nattutskillelse (8 timer i et kontrolldøgnhjemme. I fremtidige studier av melatoninsekresjon og utskillelse av metabolitt i urin, kan det være avinteresse samtidig å samle inn spørreskjemabaserte opplysninger om døgnrytmetype og utfyllende opplysningerom søvn og søvnmønster i relasjon til eksponeringer som skiftarbeid og andre arbeidsmiljøfaktorersom kan ha effekt på hormonbalansen.Tynes T, Haugsdal B, Tønnessen A, Kleiven M. Individual variations in excretion of6-sulfatoxymelatonin in morning and evening type Norwegian shift workers.Nor J Epidemiol ENGLISH SUMMARYThe aim of this study was to evaluate whether there is an association between measured values of the urinemetabolite 6-sulfatoxymelatonin (aMT6s in samples collected at selected intervals and self-reported diurnalrhythm in a group of Norwegian shift workers. The study included 19 workers at two production unitsat Hydro Porsgrunn, the magnesium factory and fertiliser factory 3. After submitting the urine samplesused for the study, subjects filled in a questionnaire on sleep and diurnal rhythm at a later date. The resultsindicate that self-reported evening type subjects have a tendency towards a higher mean hourly aMT6ssecretionfirst day on night shift, and a significantly higher night

  19. Simultaneous ocular and muscle artifact removal from EEG data by exploiting diverse statistics.

    Science.gov (United States)

    Chen, Xun; Liu, Aiping; Chen, Qiang; Liu, Yu; Zou, Liang; McKeown, Martin J

    2017-09-01

    Electroencephalography (EEG) recordings are frequently contaminated by both ocular and muscle artifacts. These are normally dealt with separately, by employing blind source separation (BSS) techniques relying on either second-order or higher-order statistics (SOS & HOS respectively). When HOS-based methods are used, it is usually in the setting of assuming artifacts are statistically independent to the EEG. When SOS-based methods are used, it is assumed that artifacts have autocorrelation characteristics distinct from the EEG. In reality, ocular and muscle artifacts do not completely follow the assumptions of strict temporal independence to the EEG nor completely unique autocorrelation characteristics, suggesting that exploiting HOS or SOS alone may be insufficient to remove these artifacts. Here we employ a novel BSS technique, independent vector analysis (IVA), to jointly employ HOS and SOS simultaneously to remove ocular and muscle artifacts. Numerical simulations and application to real EEG recordings were used to explore the utility of the IVA approach. IVA was superior in isolating both ocular and muscle artifacts, especially for raw EEG data with low signal-to-noise ratio, and also integrated usually separate SOS and HOS steps into a single unified step. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Correlation between hypoosmotic swelling test and breeding soundness evaluation of adult Nelore bulls

    Directory of Open Access Journals (Sweden)

    Tamires Miranda Neto

    2011-07-01

    Full Text Available This study aimed at evaluating the relationship between physical and morphological semen features with the hypoosmotic swelling (HOS test in raw semen of adult Nelore bulls classified as sound and unsound for breeding. Two hundred and six Nelore bulls aging from 3-10 years old were subjected to breeding soundness examination. After physical and morphological semen examination, HOS test was done. After the breeding soundness examination, 94.2% of the bulls were classified as sound for breeding. There was no difference between the average scrotal circumference of bulls classified as sound and unsound for breeding (P>0.05, but there was difference between all semen physical and morphological aspects of bulls classified as sound and unsound for breeding (P>0.05, but there was no difference in the mean percentage of reactive spermatozoa to HOS test results both for sound (38.4±17.9 and unsound animals (39.5±16.4; P>0.05, with no Pearson correlation between the HOS test and variables. According to these results HOS test can not be used alone to predict the reproductive potential of adult Nelore bulls.

  1. Preparation of highly-oxidized starch using hydrogen peroxide and its application as a novel ligand for zirconium tanning of leather.

    Science.gov (United States)

    Yu, Yue; Wang, Ya-Nan; Ding, Wei; Zhou, Jianfei; Shi, Bi

    2017-10-15

    A series of highly-oxidized starch (HOS) were prepared using H 2 O 2 and a copper-iron catalyst as a desired ligand for zirconium tanning of leather. The effects of catalyst and H 2 O 2 dosages, and reaction temperature on the oxidation degree (OD, represented as the amount of carbonyl and carboxyl groups derived) of starch were investigated. The OD reached 76.2% when oxidation was conducted using 60% H 2 O 2 and 0.015% catalyst at 98°C for 2h. 13 C NMR and FT-IR illustrated carbonyl and carboxyl groups were formed in HOS after oxidation. GPC and laser particle size analyses indicated the decrease of HOS molecular size with increasing H 2 O 2 dosage and OD. HOS with moderate OD and molecular weight was able to coordinate with zirconium and remarkably improve tanning process. Leather tanned by Zr complexes using HOS-60 (60% H 2 O 2 , Mn 3516g/mol) as ligand presented considerably better physical and organoleptic properties than those of traditional Zr-tanned leather. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Holt Oram syndrome : a registry-based study in Europe

    NARCIS (Netherlands)

    Barisic, Ingeborg; Boban, Ljubica; Greenlees, Ruth; Garne, Ester; Wellesley, Diana; Calzolari, Elisa; Addor, Marie-Claude; Arriola, Larraitz; Bergman, Jorieke E. H.; Braz, Paula; Budd, Judith L. S.; Gatt, Miriam; Haeusler, Martin; Khoshnood, Babak; Klungsoyr, Kari; McDonnell, Bob; Nelen, Vera; Pierini, Anna; Queisser-Wahrendorf, Annette; Rankin, Judith; Rissmann, Anke; Rounding, Catherine; Tucker, David; Verellen-Dumoulin, Christine; Dolk, Helen

    2014-01-01

    Background: Holt-Oram syndrome (HOS) is an autosomal dominant disorder characterised by upper limb anomalies and congenital heart defects. We present epidemiological and clinical aspects of HOS patients using data from EUROCAT (European Surveillance of Congenital Anomalies) registries. Methods: The

  3. Ludwig Wittgenstein

    DEFF Research Database (Denmark)

    Munch, Anders V.

    2006-01-01

    Filosoffen Wittgenstein var involveret i et byggeri sammen med arkitekten Paul Engelmann, elev af Adolf Loos. De filosofiske overvejelser om begrebet livsform kan belyse ideerne om den moderne arkitektur hos Loos, mens Loos' stilbegreb omvendt kan belyse sprogfilosofien hos Wittgenstein....

  4. Experimental study of APE1 RNA interference enhancing the sensitivity of neutron radiation in osteosarcoma

    International Nuclear Information System (INIS)

    Wang Dong; Qing Yi; Zhong Zhaoyang; Li Zengpeng; Zhang Xinhong; Yang Yuxin

    2007-01-01

    Objective: To knock down APE1 gene expression in HOS cells, and explore its antitumor effects in combination with 252 Cf neutron radiotherapy. Methods: pSilence APE1 siBNA plasmid was transfected into HOS cells by SuperFect Transfection liposome. The transfected HOS cells were irradiated by 252 Cf neutron, then MTY assay, clone formation assay and alkaline comet assay were used to detect the radiobiological reaction, and cell apoptosis was detected with flow cytometry. Results: The D 37 value was 3.02 vs. 2.42 in the control and transfected HOS cells respectively after irradiation with 252 Cf neutron, the DMF value is 1.43. The tail moments and cell apoptosis rate at 200, 500 and 1000 cGy showed significant difference between the two groups (P 252 Cf neutron radiotherapy may be a promising approach to therapy of human osteosarcoma in the future. (authors)

  5. Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines

    Directory of Open Access Journals (Sweden)

    Ismail Noorliza M

    2010-09-01

    Full Text Available Abstract Background The treatment of oral squamous cell carcinomas (OSCC and human osteosarcoma (HOS includes surgery and/or radiotherapy which often lead to reduced quality of life. This study was aimed to study the antiproliferative activity of local honey (Tualang on OSCC and HOS cell lines. Methods Several concentrations of Tualang honey (1% - 20% were applied on OSCC and HOS cell lines for 3, 6, 12, 24, 48 and 72 hours. Morphological characteristics were observed under light and fluorescent microscope. Cell viability was assessed using MTT assay and the optical density for absorbance values in each experiment was measured at 570 nm by an ELISA reader. Detection of cellular apoptosis was done using the Annexin V-FITC Apoptosis Detection Kit. Results Morphological appearance showed apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation and fragmented nucleus on OSCC and HOS cell lines. Cell viability assay showed a time and dose-dependent inhibitory effect of honey on both cell lines. The 50% inhibitory concentration (IC50 for OSCC and HOS cell lines was found to be 4% and 3.5% respectively. The maximum inhibition of cell growth of ≥80% was obtained at 15% for both cell lines. Early apoptosis was evident by flow cytometry where percentage of early apoptotic cells increased in dose and time dependent manner. Conclusion Tualang honey showed antiproliferative effect on OSCC and HOS cell lines by inducing early apoptosis.

  6. OCD og orofaciale dyskinesier forårsaget af sjælden basalganglielidelse

    DEFF Research Database (Denmark)

    Elmgreen, Søren Bruno; Danielsen, Erik Hvid

    2014-01-01

    Bevægeforstyrrelser hos psykiatriske patienter skyldes sædvanligvis ekstrapyramidale bivirkninger til antipsykotisk medicin. Her beskrives en sjælden årsag til orofaciale dyskinesier, tungedystoni og koreiforme bevægelser hos en 31-årig mand i behandling for obsessiv-kompulsiv lidelse (OCD)....

  7. A practical approach to the management of high-output stoma

    Science.gov (United States)

    Mountford, Christopher G; Manas, Derek M; Thompson, Nicholas P

    2014-01-01

    The development of a high-output stoma (HOS) is associated with water, electrolyte and nutritional complications. Prompt, careful assessment and management is required to avoid rapid clinical deterioration in this patient population. A multidisciplinary approach to management ensures the best possible outcome and quality of life for patients who experience HOS. This article outlines the important considerations in the identification and pathophysiology of HOS. A systematic approach to the management of the condition is outlined, considering fluid and electrolyte requirements, nutrient deficiencies and manipulation of gastrointestinal absorption, motility and secretions using medical and surgical therapies. PMID:28839771

  8. Novel mutations in the TBX5 gene in patients with Holt-Oram Syndrome

    Directory of Open Access Journals (Sweden)

    Marianna P.R. Porto

    2010-01-01

    Full Text Available The Holt-Oram syndrome (HOS is an autosomal dominant condition characterized by upper limb and cardiac malformations. Mutations in the TBX5 gene cause HOS and have also been associated with isolated heart and arm defects. Interactions between the TBX5, GATA4 and NKX2.5 proteins have been reported in humans. We screened the TBX5, GATA4, and NKX2.5 genes for mutations, by direct sequencing, in 32 unrelated patients presenting classical (8 or atypical HOS (1, isolated congenital heart defects (16 or isolated upper-limb malformations (7. Pathogenic mutations in the TBX5 gene were found in four HOS patients, including two new mutations (c.374delG; c.678G > T in typical patients, and the hotspot mutation c.835C > T in two patients, one of them with an atypical HOS phenotype involving lower-limb malformations. Two new mutations in the GATA4 gene were found in association with isolated upper-limb malformations, but their clinical significance remains to be established. A previously described possibly pathogenic mutation in the NKX2.5 gene (c.73C > 7 was detected in a patient with isolated heart malformations and also in his clinically normal father.

  9. Assessment of higher order structure comparability in therapeutic proteins using nuclear magnetic resonance spectroscopy.

    Science.gov (United States)

    Amezcua, Carlos A; Szabo, Christina M

    2013-06-01

    In this work, we applied nuclear magnetic resonance (NMR) spectroscopy to rapidly assess higher order structure (HOS) comparability in protein samples. Using a variation of the NMR fingerprinting approach described by Panjwani et al. [2010. J Pharm Sci 99(8):3334-3342], three nonglycosylated proteins spanning a molecular weight range of 6.5-67 kDa were analyzed. A simple statistical method termed easy comparability of HOS by NMR (ECHOS-NMR) was developed. In this method, HOS similarity between two samples is measured via the correlation coefficient derived from linear regression analysis of binned NMR spectra. Applications of this method include HOS comparability assessment during new product development, manufacturing process changes, supplier changes, next-generation products, and the development of biosimilars to name just a few. We foresee ECHOS-NMR becoming a routine technique applied to comparability exercises used to complement data from other analytical techniques. Copyright © 2013 Wiley Periodicals, Inc.

  10. Spectrum analysis of radiotracer residence time distribution for industrial and environmental applications

    International Nuclear Information System (INIS)

    Kasban, H.; Ashraf Hamid

    2014-01-01

    Radiotracer signal analysis and recognition still represents challenges in industrial and environmental applications specially in residence time distribution (RTD) measurement. This paper presents a development for the RTD signal recognition method that is based on power density spectrum (PDS). In this development, the features are extracted from the signals and/or from their higher-orders statistics (HOS) (Bispectrum and Trispectrum) instead of PDS. The HOS are estimated using direct, indirect and parametric estimations. The recognition results are analyzed and compared for different HOS estimation in order to select the best HOS estimation method for the purpose of RTD signal recognition. The artificial neural networks are used for training and testing of the proposed method. The proposed method is tested using RTD signals obtained from the measurements carried out using radiotracer technique. The simulation results show that the parametric estimation of the Trispectrum gives the higher recognition rate and is the most reliable for the RTD signal recognition. (author)

  11. Changes in the structural and biochemical composition of the arterial wall in type 2 diabetes patients

    DEFF Research Database (Denmark)

    Rørdam Preil, Simone

    Arteriel stivhed er et normalt aldersbetinget fænomen. Hos patienter med type 2 diabetes synes udviklingen af arteriel stivhed accelereret, hvilket kunne være årsagen til den forøgede incidens af kardiovaskulære sygdomme hos disse patienter. Ophobningen af kollagen og/eller nedbrydningen af elastin...... ikke-atherosclerotisk arterievæv fra patienter med og uden type 2 diabetes. Arteriesnittene fra mammaria arterierne blev farvet for makrofager, elastin, kollagen og α smooth muscle actin, hvorefter vi målte området for kollagen og elastin og antallet af celler, der farves for α smooth muscle actin, ved...... laget signifikant lavere hos patienter med diabetes, og kollagen farvningen viste et større farvet område i intima og media lagene hos type 2 diabetes patienter end for patienterne uden diabetes. Ydermere forholder det sig således, at størstedelen af patienter med type 2 diabetes bliver behandlet med...

  12. Kognition, evolution og Bibel

    DEFF Research Database (Denmark)

    Jensen, Hans Jørgen Lundager

    2012-01-01

    En opfordring til, at Bibelvidneskaberne oprienterer sig i retning af aktuelle teorier om bio-kulturel evolution (Merlin Donald, aksetids-teori hos fx Robert Bellah)......En opfordring til, at Bibelvidneskaberne oprienterer sig i retning af aktuelle teorier om bio-kulturel evolution (Merlin Donald, aksetids-teori hos fx Robert Bellah)...

  13. Nordic Branding Podcast 1

    DEFF Research Database (Denmark)

    2017-01-01

    Hvilke værdier er 'Nordiske'? Vi starter hos Brandbase i Odense og ser på WODENs Skandinaviske sneakers og Jim Lyngvilds vilde branding.......Hvilke værdier er 'Nordiske'? Vi starter hos Brandbase i Odense og ser på WODENs Skandinaviske sneakers og Jim Lyngvilds vilde branding....

  14. Validation of the Spanish version of the Hip Outcome Score: a multicenter study.

    Science.gov (United States)

    Seijas, Roberto; Sallent, Andrea; Ruiz-Ibán, Miguel Angel; Ares, Oscar; Marín-Peña, Oliver; Cuéllar, Ricardo; Muriel, Alfonso

    2014-05-13

    The Hip Outcome Score (HOS) is a self-reported questionnaire evaluating the outcomes of treatment interventions for hip pathologies, divided in 19 items of activities of daily life (ADL) and 9 sports' items. The aim of the present study is to translate and validate HOS into Spanish. A prospective and multicenter study with 100 patients undergoing hip arthroscopy was performed between June 2012 and January 2013. Crosscultural adaptation was used to translate HOS into Spanish. Patients completed the questionnaire before and after surgery. Feasibility, reliability, internal consistency, construct validity (correlation with Western Ontario and McMaster Universities Osteoarthritis Index), ceiling and floor effects and sensitivity to change were assessed for the present study. Mean age was 45.05 years old. 36 women and 64 men were included. Feasibility: 13% had at least one missing item within the ADL subscale and 17% within the sport subscale. Reliability: the translated version of HOS was highly reproducible with intraclass correlation coefficient of 0.95 for ADL and 0.94 for the sports subscale. Internal consistency was confirmed with Cronbach's alpha >0.90 in both subscales. Construct validity showed statistically significant correlation with WOMAC. Ceiling effect was observed in 6% and 12% for ADL and sports subscale, respectively. Floor effect was found in 3% and 37% ADL and sports subscale, respectively. Large sensitivity to change was shown in both subscales. The translated version of HOS into Spanish has shown to be feasible, reliable and sensible to changes for patients undergoing hip arthroscopy. This validated translation of HOS allows for comparisons between studies involving either Spanish- or English-speaking patients. Prognostic study, Level I.

  15. New-onset atrial fibrillation after acute myocardial infarction in patients with left ventricular systolic dysfunction recorded by an Implantable Cardiac Monitor - Incidence, prediction and prognosis

    DEFF Research Database (Denmark)

    Jøns, Christian

    2010-01-01

    BAGGRUND OG FORMÅL Forekomsten af atrieflimren (AF) er øget hos patienter med akut myokardieinfarkt og venstre ventrikel dysfunction (defineret som LVEF ≤ 40%), men langtidsforekomst og prognose for nyopstået AF hos denne population er ukendt. Formålet med denne afhandling er, at undersøge foreko...

  16. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions about Using History of Science to Teach NOS

    Science.gov (United States)

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-01-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing…

  17. Numerical Simulation of a Seaway with Breaking

    Science.gov (United States)

    Dommermuth, Douglas; O'Shea, Thomas; Brucker, Kyle; Wyatt, Donald

    2012-11-01

    The focus of this presentation is to describe the recent efforts to simulate a fully non-linear seaway with breaking by using a high-order spectral (HOS) solution of the free-surface boundary value problem to drive a three-dimensional Volume of Fluid (VOF) solution. Historically, the two main types of simulations to simulate free-surface flows are the boundary integral equations method (BIEM) and high-order spectral (HOS) methods. BIEM calculations fail at the point at which the surface impacts upon itself, if not sooner, and HOS methods can only simulate a single valued free-surface. Both also employ a single-phase approximation in which the effects of the air on the water are neglected. Due to these limitations they are unable to simulate breaking waves and air entrainment. The Volume of Fluid (VOF) method on the other hand is suitable for modeling breaking waves and air entrainment. However it is computationally intractable to generate a realistic non-linear sea-state. Here, we use the HOS solution to quickly drive, or nudge, the VOF solution into a non-linear state. The computational strategies, mathematical formulation, and numerical implementation will be discussed. The results of the VOF simulation of a seaway with breaking will also be presented, and compared to the single phase, single valued HOS results.

  18. The Use of Help Options in Multimedia Listening Environments to Aid Language Learning: A Review

    Science.gov (United States)

    Mohsen, Mohammed Ali

    2016-01-01

    This paper provides a comprehensive review on the use of help options (HOs) in the multimedia listening context to aid listening comprehension (LC) and improve incidental vocabulary learning. The paper also aims to synthesize the research findings obtained from the use of HOs in Computer-Assisted Language Learning (CALL) literature and reveals the…

  19. Signal transduction and downregulation of C-MET in HGF stimulated low and highly metastatic human osteosarcoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Husmann, Knut, E-mail: khusmann@research.balgrist.ch [Laboratory for Orthopedic Research, Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich (Switzerland); Ducommun, Pascal [Laboratory for Orthopedic Research, Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich (Switzerland); Division of Plastic Surgery and Hand Surgery, Department of Surgery, University Hospital Zurich, Zurich (Switzerland); Sabile, Adam A.; Pedersen, Else-Marie; Born, Walter; Fuchs, Bruno [Laboratory for Orthopedic Research, Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich (Switzerland)

    2015-09-04

    The poor outcome of osteosarcoma (OS), particularly in patients with metastatic disease and a five-year survival rate of only 20%, asks for more effective therapeutic strategies targeting malignancy-promoting mechanisms. Dysregulation of C-MET, its ligand hepatocyte growth factor (HGF) and the fusion oncogene product TPR-MET, first identified in human MNNG-HOS OS cells, have been described as cancer-causing factors in human cancers. Here, the expression of these molecules at the mRNA and the protein level and of HGF-stimulated signaling and downregulation of C-MET was compared in the parental low metastatic HOS and MG63 cell lines and the respective highly metastatic MNNG-HOS and 143B and the MG63-M6 and MG63-M8 sublines. Interestingly, expression of TPR-MET was only observed in MNNG-HOS cells. HGF stimulated the phosphorylation of Akt and Erk1/2 in all cell lines investigated, but phospho-Stat3 remained at basal levels. Downregulation of HGF-stimulated Akt and Erk1/2 phosphorylation was much faster in the HGF expressing MG63-M8 cells than in HOS cells. Degradation of HGF-activated C-MET occurred predominantly through the proteasomal and to a lesser extent the lysosomal pathway in the cell lines investigated. Thus, HGF-stimulated Akt and Erk1/2 signaling as well as proteasomal degradation of HGF activated C-MET are potential therapeutic targets in OS. - Highlights: • Expression of TPR-MET was only observed in MNNG-HOS cells. • HGF stimulated the phosphorylation of Akt and Erk1/2 but not of Stat3 in osteosarcoma cell lines. • Degradation of HGF-activated C-MET occurred predominantly through the proteasomal pathway.

  20. Undersøgelse for Mycoplasma bovis i praksislaboratoriet

    DEFF Research Database (Denmark)

    Krogh, Kaspar; Kokotovic, Branko; Voss, Heidi

    2012-01-01

    Mycoplasma anses for at være en medvirkende årsag til en lang række sygdomsforløb hos kvæg og andre dyrearter.......Mycoplasma anses for at være en medvirkende årsag til en lang række sygdomsforløb hos kvæg og andre dyrearter....

  1. Over-expression of NAD kinase in Corynebacterium crenatum and ...

    African Journals Online (AJOL)

    in Corynebacterium crenatum SYPA5-5 and to study its impact in presence of high (HOS) ... Results: In HOS condition, NAD+ kinase activity increased by 116 %, while ... (NADPH), an important co-enzyme during ... Polymerase, TaKaRa) using C. crenatum .... were washed with cold 100 mM PBS (pH 7.5) ..... Catalase and.

  2. Prevalencia y carga parasitaria de helmintos gastrointestinales en gallinas de traspatio (Gallus Gallus Domesticus), en el municipio de El Sauce, departamento de León, Nicaragua

    DEFF Research Database (Denmark)

    Olivares, L. Luna; Kyvsgaard, Niels Chr.; Rimbaud, E.

    2006-01-01

    Prævalens og parasitbyrde af gastrointestinale helminter hos fritgående høns (Gallus gallus domesticus) i El Sauce kommune, León departementet, Nicaragua......Prævalens og parasitbyrde af gastrointestinale helminter hos fritgående høns (Gallus gallus domesticus) i El Sauce kommune, León departementet, Nicaragua...

  3. El monstruo en cine y literatura

    DEFF Research Database (Denmark)

    Cifuentes-Aldunate, Claudio

    2012-01-01

    Det drejer sig om 4 artikler af forskellige forfatter, som reflekter om monsterets figuren i en konkret film (El espíritu de la colmena) og hos flere fiktionsforfatter som Mario Vargas Llosa, Ernesto Sábato, José Bianco, Jorge Luis Borges,etc. MIn egen artikel centrere sig i monsteret hos José Do...

  4. On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods.

    Science.gov (United States)

    Poppe, Leszek; Jordan, John B; Rogers, Gary; Schnier, Paul D

    2015-06-02

    An important aspect in the analytical characterization of protein therapeutics is the comprehensive characterization of higher order structure (HOS). Nuclear magnetic resonance (NMR) is arguably the most sensitive method for fingerprinting HOS of a protein in solution. Traditionally, (1)H-(15)N or (1)H-(13)C correlation spectra are used as a "structural fingerprint" of HOS. Here, we demonstrate that protein fingerprint by line shape enhancement (PROFILE), a 1D (1)H NMR spectroscopy fingerprinting approach, is superior to traditional two-dimensional methods using monoclonal antibody samples and a heavily glycosylated protein therapeutic (Epoetin Alfa). PROFILE generates a high resolution structural fingerprint of a therapeutic protein in a fraction of the time required for a 2D NMR experiment. The cross-correlation analysis of PROFILE spectra allows one to distinguish contributions from HOS vs protein heterogeneity, which is difficult to accomplish by 2D NMR. We demonstrate that the major analytical limitation of two-dimensional methods is poor selectivity, which renders these approaches problematic for the purpose of fingerprinting large biological macromolecules.

  5. Skal domstole være demokratisk tilgængelige?

    DEFF Research Database (Denmark)

    Schaumburg-Müller, Sten

    2009-01-01

    Domstolenes rolle i forhold til den demokratiske tilgængelighed stilles til debat. Spørgsmålet er uklart både i teorien (såvel hos Montesquieu om magtens tredeling som hos Habermas om den borgerlige offentlighed), i loven og i den retlige praksis. Det foreslås at alle, herunder politikere som...

  6. Ny vaccine mod ledbetændelse er ikke effektiv

    DEFF Research Database (Denmark)

    Nielsen, Elisabeth Okholm; Lauritsen, Klara Tølbøll

    2013-01-01

    En ny mulighed for at vaccinere mod mykoplasma-ledbetændelse er undersøgt hos en slagtesvineproducent. Vaccinen kunne desværre ikke forebygge halthed eff ektivt.......En ny mulighed for at vaccinere mod mykoplasma-ledbetændelse er undersøgt hos en slagtesvineproducent. Vaccinen kunne desværre ikke forebygge halthed eff ektivt....

  7. Technology and Learning

    DEFF Research Database (Denmark)

    Guttorm Andersen, Pia; Hansen, Ole

    Teknologier giver adgang til viden - og med viden forøges handlemulighederne. Teknologier nedbryder traditionelle barrierer som tid og sted. Teknologier øger kompetencerne hos den enkelte borger......Teknologier giver adgang til viden - og med viden forøges handlemulighederne. Teknologier nedbryder traditionelle barrierer som tid og sted. Teknologier øger kompetencerne hos den enkelte borger...

  8. How In-Service Science Teachers Integrate History and Nature of Science in Elementary Science Courses

    Science.gov (United States)

    Hacieminoglu, Esme

    2014-01-01

    The purpose of this study is to investigate how the in-service science teachers' (IST) perceptions and practices about curriculum and integration of the history of science (HOS) and the nature of science (NOS) affect their science courses. For this aim, how ISTs integrated the NOS and HOS in their elementary science courses for understanding of…

  9. Zoonoser er andet og mere end fødevarebårne sygdomme

    DEFF Research Database (Denmark)

    Guardabassi, Luca; Bisgaard, Magne

    2007-01-01

    Ingen af de bedst kendte zoonoser i historien er fødevarebårne - reelt har det vist sig, at mange nye infektionssygdomme hos mennesker stammer fra dyr.......Ingen af de bedst kendte zoonoser i historien er fødevarebårne - reelt har det vist sig, at mange nye infektionssygdomme hos mennesker stammer fra dyr....

  10. Demens: ikke farmakologiske interventioner - en kommenteret udenlandsk medicinsk teknologivurdering

    DEFF Research Database (Denmark)

    Sørensen, Lisbeth Villemoes

    Fysisk træning som gang, styrketræning og yoga kan hæmme udvikling af demens hos raske ældre og forbedre fysisk funktion hos personer med demens. Det peger en undersøgelse fra Sundhedsstyrelsen på. Undersøgelsen belyser effekten af ikke-medicinske indsatser til personer med og uden demens. Der er...

  11. Demens: ikke farmakologiske interventioner - en kommenteret udenlandsk medicinsk teknologivurdering

    DEFF Research Database (Denmark)

    Sørensen, Lisbeth Villemoes

    2010-01-01

    Fysisk træning som gang, styrketræning og yoga kan hæmme udvikling af demens hos raske ældre og forbedre fysisk funktion hos personer med demens. Det peger en undersøgelse fra Sundhedsstyrelsen på. Undersøgelsen belyser effekten af ikke-medicinske indsatser til personer med og uden demens. Der er...

  12. Humor er en alvorlig sag

    DEFF Research Database (Denmark)

    Søltoft, Pia

    2016-01-01

    I modsætning til ironi er humor for Kierkegaard fællesskabsgivende – ironikeren hævder sig selv, men humoristen har sympati med den, man ler med. Humor er hos Kierkegaard udtryk for, at humoristen forliger sig med tilværelsen og dens luner, og dermed grænser humoren hos Kierkegaard op til det...

  13. Genetic profiling of two phenotypically distinct outbred rats derived from a colony of the Zucker fatty rats maintained at Tokyo Medical University

    Science.gov (United States)

    Nakanishi, Satoshi; Kuramoto, Takashi; Kashiwazaki, Naomi; Yokoi, Norihide

    2016-01-01

    The Zucker fatty (ZF) rat is an outbred rat and a well-known model of obesity without diabetes, harboring a missense mutation (fatty, abbreviated as fa) in the leptin receptor gene (Lepr). Slc:Zucker (Slc:ZF) outbred rats exhibit obesity while Hos:ZFDM-Leprfa (Hos:ZFDM) outbred rats exhibit obesity and type 2 diabetes. Both outbred rats have been derived from an outbred ZF rat colony maintained at Tokyo Medical University. So far, genetic profiles of these outbred rats remain unknown. Here, we applied a simple genotyping method using Ampdirect reagents and FTA cards (Amp-FTA) in combination with simple sequence length polymorphisms (SSLP) markers to determine genetic profiles of Slc:ZF and Hos:ZFDM rats. Among 27 SSLP marker loci, 24 loci (89%) were fixed for specific allele at each locus in Slc:ZF rats and 26 loci (96%) were fixed in Hos:ZFDM rats, respectively. This indicates the low genetic heterogeneity in both colonies of outbred rats. Nine loci (33%) showed different alleles between the two outbred rats, suggesting considerably different genetic profiles between the two outbred rats in spite of the same origin. Additional analysis using 72 SSLP markers further supported these results and clarified the profiles in detail. This study revealed that genetic profiles of the Slc:ZF and Hos:ZFDM outbred rats are different for about 30% of the SSLP marker loci, which is the underlying basis for the phenotypic difference between the two outbred rats. PMID:27795491

  14. Peter in the Gospel of Mark and in Early Christianity in Rome

    DEFF Research Database (Denmark)

    Willert, Niels

    1997-01-01

    Artiklen gennemgår Markusevangeliets portræt af apostlen Peter og drøfter spørgsmålet, hvorfor Peter er så negativt skildret hos Markus. Litterære og pædagogiske (indirekte formaning til datidens kristne) intentioner forklarer først og fremmest dette træk hos Markus. Men også historiske spørgsmål...

  15. Linguatula serrata in Swedish reindeer (Rangifer tarandus L

    Directory of Open Access Journals (Sweden)

    Claes Rehbinder

    1982-05-01

    Full Text Available A high prevalence (24,2% of the tongue-worm Lingutula serrata was found in reindeer yearlings. Apparently the high incidence found in this material indicates that the parasite is well adapted to reindeer; the reaction of the nasal mucosa is very mild. The abscence of clinical manifestations and the hidden localization in sinuses which are rarely inspected at slaughter or autopsy is most probably the reason why L. serrata is seldom observed.Tungmask (Linguatula serrata hos svensk skogsren.Abstract in Swedish / Sammandrag: En hög frekvens(24,2% av tungmask (Linguatula serrata påvisades hos årskalv av skogsren. Den ringa våvnadsreaktion som forelag antyder att L serrata troligen ar val anpassad till ren. Att endast ett fåtal rapporter om forekomst av L serrata hos ren foreligger torde bero på att parasiten inte ger några kliniska symptom samt dess i huvudsak gomda lokalisation i overkåkshåligheterna vilka sållan inspekteras vid slakt eller obduktion. L serrata år dårfor sannolikt vanligare hos svenska renar ån man tidigare antagit.

  16. Patient-Reported Outcome questionnaires for hip arthroscopy: a systematic review of the psychometric evidence

    Science.gov (United States)

    2011-01-01

    Background Hip arthroscopies are often used in the treatment of intra-articular hip injuries. Patient-reported outcomes (PRO) are an important parameter in evaluating treatment. It is unclear which PRO questionnaires are specifically available for hip arthroscopy patients. The aim of this systematic review was to investigate which PRO questionnaires are valid and reliable in the evaluation of patients undergoing hip arthroscopy. Methods A search was conducted in Pubmed, Medline, CINAHL, the Cochrane Library, Pedro, EMBASE and Web of Science from 1931 to October 2010. Studies assessing the quality of PRO questionnaires in the evaluation of patients undergoing hip arthroscopy were included. The quality of the questionnaires was evaluated by the psychometric properties of the outcome measures. The quality of the articles investigating the questionnaires was assessed by the COSMIN list. Results Five articles identified three questionnaires; the Modified Harris Hip Score (MHHS), the Nonarthritic Hip Score (NAHS) and the Hip Outcome Score (HOS). The NAHS scored best on the content validity, whereas the HOS scored best on agreement, internal consistency, reliability and responsiveness. The quality of the articles describing the HOS scored highest. The NAHS is the best quality questionnaire. The articles describing the HOS are the best quality articles. Conclusions This systematic review shows that there is no conclusive evidence for the use of a single patient-reported outcome questionnaire in the evaluation of patients undergoing hip arthroscopy. Based on available psychometric evidence we recommend using a combination of the NAHS and the HOS for patients undergoing hip arthroscopy. PMID:21619610

  17. Molecular cloning and expression analysis of KIN10 and cold-acclimation related genes in wild banana 'Huanxi' (Musa itinerans).

    Science.gov (United States)

    Liu, Weihua; Cheng, Chunzhen; Lai, Gongti; Lin, Yuling; Lai, Zhongxiong

    2015-01-01

    Banana cultivars may experience chilling or freezing injury in some of their cultivated regions, where wild banana can still grow very well. The clarification of the cold-resistant mechanism of wild banana is vital for cold-resistant banana breeding. In this study, the central stress integrator gene KIN10 and some cold-acclimation related genes (HOS1 and ICE1s) from the cold-resistant wild banana 'Huanxi' (Musa itinerans) were cloned and their expression patterns under different temperature treatments were analyzed. Thirteen full-length cDNA transcripts including 6 KIN10s, 1 HOS1 and 6 ICE1s were successfully cloned. Quantitative real-time PCR (qRT-PCR) results showed that all these genes had the highest expression levels at the critical temperature of banana (13 °C). Under chilling temperature (4 °C), the expression level of KIN10 reduced significantly but the expression of HOS1 was still higher than that at the optimal temperature (28 °C, control). Both KIN10 and HOS1 showed the lowest expression levels at 0 °C, the expression level of ICE1, however, was higher than control. As sucrose plays role in plant cold-acclimation and in regulation of KIN10 and HOS1 bioactivities, the sucrose contents of wild banana under different temperatures were detected. Results showed that the sucrose content increased as temperature lowered. Our result suggested that KIN10 may participate in cold stress response via regulating sucrose biosynthesis, which is helpful in regulating cold acclimation pathway in wild banana.

  18. Foderstater för ökad konsumtion av vallfoder

    DEFF Research Database (Denmark)

    Hetta, M.; Lund, Peter; Tahir, M.N.

    2011-01-01

    nedbrytningen från våmmen till tunntarmen. Nedbrytning av stärkelse i tunntarmen leder till högre energieffektivitet i ämnesomsättningen. Stärkelse hos korn (Hordeum Vulgare, L) anses i litteraturen ha en snabb omsättning i våmmen och stärkelse hos majs (Zea Mays, L) anses ha en långsam nedbrytning (Mills et al...

  19. Forsegling af okklusal dentincaries i permanente molarer

    DEFF Research Database (Denmark)

    Qvist, Vibeke; Borum, Mette Kit; Dynes Møller, Kirsten

    2017-01-01

    Der findes ingen eksakte tal for forekomsten af fødevareallergi i den danske befolkning. Den kumulerede forekomst af fødevareallergi hos børn i de første tre leveår skønnes at være på 7-8 %, hvoraf hovedparten vokser sig fra det. Punktprævalensen af diagnosticeret fødevareallergi hos voksne er 3 ...

  20. Wall Street som kreationistisk forkynder

    DEFF Research Database (Denmark)

    Ekman, Susanne

    2016-01-01

    Artiklen gennemgår Karen Hos etnografi om Wall Street: "Liquidated: An ethnography of Wall Street" set i lyset af den offentlige debat vedrørende Goldman Sachs opkøb af Dong......Artiklen gennemgår Karen Hos etnografi om Wall Street: "Liquidated: An ethnography of Wall Street" set i lyset af den offentlige debat vedrørende Goldman Sachs opkøb af Dong...

  1. Unges motivation i udskolingen

    DEFF Research Database (Denmark)

    Pless, Mette; Katznelson, Noemi; Hjort-Madsen, Peder

    Om hvordan de unge i udskolingen skaber lyst og motivation for læring. Med afsnit om hvad motivation er, hvordan den fremmes hos unge og kombineres med et liv udenfor skolen......Om hvordan de unge i udskolingen skaber lyst og motivation for læring. Med afsnit om hvad motivation er, hvordan den fremmes hos unge og kombineres med et liv udenfor skolen...

  2. Statens diagram

    DEFF Research Database (Denmark)

    Thyssen, Ole

    2016-01-01

    Når vi skal følge statens legender, må vi træffe et valg. Hvilket ord skal vi bruge, og var der stater før ordet "stat" kom til verden? Ordet blev brugt i 1500-tallet hos Machiavelli og før det hos Thomas Aquinas, hvor status ikke blot betød "stand", men også et samfunds "tilstand" eller forfatning...

  3. Vaccine mod halthed testes i besætning

    DEFF Research Database (Denmark)

    Lauritsen, Klara Tølbøll

    2012-01-01

    Ny vaccine mod ledbetændelse forårsaget af Mycoplasma hyosynoviae testes nu hos 200 svin i en problembesætning. Håbet er færre halte svin og en nedbringelse af antibiotikaforbruget.......Ny vaccine mod ledbetændelse forårsaget af Mycoplasma hyosynoviae testes nu hos 200 svin i en problembesætning. Håbet er færre halte svin og en nedbringelse af antibiotikaforbruget....

  4. Herbert Marcuse

    DEFF Research Database (Denmark)

    Dupont, Søren

    2009-01-01

    Artiklen placerer Herbert Marcuse som en kritisk tværvidenskabelig tænker med linier til både Karl Marx og Sigmund Freud. Den utopiske dimension hos Herbert Marcuse præsenteres og diskuteres.......Artiklen placerer Herbert Marcuse som en kritisk tværvidenskabelig tænker med linier til både Karl Marx og Sigmund Freud. Den utopiske dimension hos Herbert Marcuse præsenteres og diskuteres....

  5. Correlation of RAD51 and radiosensitization of methotrexate

    International Nuclear Information System (INIS)

    Du Liqing; Bai Jianqiang; Liu Qiang; Wang Yan; Zhao Peng; Chen Fenghua; Wang Hong; Fan Feiyue

    2012-01-01

    Objective: To evaluate the correlation between homologous recombination repair protein RAD51 and methotrexate-enhanced radiosensitivity. Methods: Western blot and RT-PCR assays were used to detect RAD51 expression in HOS osteosarcoma cells exposed to γ-ray irradiation alone and in combination with methotrexate. Colony formation assay was used to test the survival fraction of HOS cells exposed to γ-rays and methotrexate. Results: Methotrexate inhibited both protein and RNA expressions of RAD51, and the combination of radiation and methotrexate enhanced the inhibition of RAD51 expression. Moreover, transfection of cells with RAD51 gene decreased cellular sensitivity to methotrexate and γ-rays. The sensitizer enhancement ratios after irradiation in combination with methotrexate were 1.51 and 0.99, respectively. Methotrexate was a preferred radiosensitizer to HOS cell. Conclusions: RAD51 might be involved in the methotrexate-enhanced radiosensitivity. (authors)

  6. Shared Oral Care

    DEFF Research Database (Denmark)

    Hede, Børge; Elmelund Poulsen,, Johan; Christophersen, Rasmus

    2014-01-01

    Shared Oral Care - Forebyggelse af orale sygdomme på plejecentre Introduktion og formål: Mangelfuld mundhygiejne hos plejekrævende ældre er et alment og veldokumenteret sundhedsproblem, der kan føre til massiv udvikling af tandsygdomme, og som yderligere kan være medvirkende årsag til alvorlige...... ressourceanvendelse er muligt at skabe en betydeligt forbedret mundhygiejne hos plejekrævende ældre Key words: Geriatric dentistry, nursing home, community health services, prevention, situated learning...

  7. History and Nature of Science enriched Problem-Based Learning on the origins of biodiversity and of continents and oceans

    OpenAIRE

    Sousa, Cristina

    2014-01-01

    [EN] The episode of the History of Science (HOS) on the theory of continental drift proposed by Alfred Wegener has been considered an excellent example for teaching students aspects of Nature of Science (NOS) and the relation of Science with social and tecnological contexts. We implemented a NOS and HOS-enriched Problem-Based Learning environment at the middle (year 7 of the Portuguese National Curriculum) and secondary level (year 10) for teaching the origins of biodiversity and of continent...

  8. Estimation of Seismic Wavelets Based on the Multivariate Scale Mixture of Gaussians Model

    Directory of Open Access Journals (Sweden)

    Jing-Huai Gao

    2009-12-01

    Full Text Available This paper proposes a new method for estimating seismic wavelets. Suppose a seismic wavelet can be modeled by a formula with three free parameters (scale, frequency and phase. We can transform the estimation of the wavelet into determining these three parameters. The phase of the wavelet is estimated by constant-phase rotation to the seismic signal, while the other two parameters are obtained by the Higher-order Statistics (HOS (fourth-order cumulant matching method. In order to derive the estimator of the Higher-order Statistics (HOS, the multivariate scale mixture of Gaussians (MSMG model is applied to formulating the multivariate joint probability density function (PDF of the seismic signal. By this way, we can represent HOS as a polynomial function of second-order statistics to improve the anti-noise performance and accuracy. In addition, the proposed method can work well for short time series.

  9. [gammadelta T cells stimulated by zoledronate kill osteosarcoma cells].

    Science.gov (United States)

    Jiang, Hui; Xu, Qiang; Yang, Chao; Cao, Zhen-Guo; Li, Zhao-Xu; Ye, Zhao-Ming

    2010-12-01

    To investigate the cytotoxicity of human γδT cells from PBMCs stimulated by zoledronate against osteosarcoma cell line HOS in vitro and in vivo and evaluate the relavent pathways. The peripheral blood mononuclear cells (PBMCs)of healthy donors were stimulated by single dose zoledronate and cultured in the present of IL-2 for two weeks, analysising the percentage of γδT cells on a FACSCalibur cytometer.Study the cytotoxicity of γδT cells against the osteosarcoma line HOS using LDH release assay kit. Pre-treatment of γδT cells with anti-human γδTCR antibody, anti-human NKG2D antibody and concanamycin A to bolck the relavent pathways for evaluating the mechenisms of its cytotoxicity. In vivo, BALB/c mice were inoculated subcutaneously osteosarcoma cell HOS for developing hypodermal tumors. And they were randomized into two groups: unteated group, γδT cell therapy group. Tumor volume and weight of the two groups were compared. After two weeks of culture, γδT cells from zoledronate-stimulated PBMCs could reach (95±3)%. When the E:T as 6:1, 12:1, 25:1, 50:1, the percentage of osteosarcoma cell HOS killed by γδT cells was 26.8%, 31.5%, 37.8%, 40.9%, respectively.When anti-huma γδTCR antibody, anti-human NKG2D antibody and concanamycin A blocked the relavent pathways, the percentage was 32.3%, 4.7%, 16.7% ( E:T as 25:1), respectively. In vivo, the tumor inhibition rate of the group of γδT cell therapy was 42.78%. γδT cells derived from PBMCs stimulated by zoledronate can acquired pure γδT cells. And they show strong cytoxicity against osteosarcoma cell line HOS in vitro and in vivo.

  10. Proposed performance standards for the Agricultural Hazardous Occupations Order certification training program.

    Science.gov (United States)

    French, B F; Field, W E; Tormoehlen, R

    2007-07-01

    The performance standards that accompany Gearing Up for Safety, the agricultural production safety training curriculum for youth, were designed to meet the certification testing requirements of the Agricultural Hazardous Occupations Order (AgHOs) certification training program. The AgHOs requires that certain youth who are older than 13 and younger than 16 years of age complete a prescribed training program before being eligible for employment on farms to perform certain tasks considered hazardous. These training resources will be available for implementation and can be accessed by contacting the second author. To our knowledge, up until this time, few, if any, standardized testing procedures or instruments have had the necessary psychometric evidence to support use of the resulting scores to assess the readiness of youth to meet the basic certification requirements contained in the AgHOs. This article describes the rationale, methods, and key findings from a standard-setting session held to establish minimum passing scores for a proposed testing process. The test will be used as a component of the Gearing Up for Safety certification process for youth workers seeking employment to perform job functions as specified under the AgHOs. Readers may be able to apply this standardized testing process, or similarly accepted processes, to other or future testing and certification projects involving agricultural safety and health.

  11. Increased risk of nonalcoholic fatty liver disease with occupational stress in Chinese policemen: A 4-year cohort study.

    Science.gov (United States)

    Li, Chen; Xing, Jing-Jing; Shan, An-Qi; Leng, Ling; Liu, Jin-Chuan; Yue, Song; Yu, Hao; Chen, Xi; Tian, Feng-Shi; Tang, Nai-Jun

    2016-11-01

    Nonalcoholic fatty liver disease (NAFLD) and occupational stress have been recognized as major public health concerns. We aimed to explore whether occupational stress was associated with NAFLD in a police population.A total of 6559 male police officers were recruited for this prospective study in April 2007. Among them, 2367 eligible subjects participated in follow-up from 2008 to 2011. NAFLD was diagnosed based on standard criteria. Occupational stress was evaluated by Occupational Stress Inventory-Revised scores.The incidence of NAFLD was 31.2% in the entire police. After adjusting for traditional risk factors, moderate occupational stress (MOS), high occupational stress (HOS), and high personal strain (HPS) were risk factors (MOS: hazard ratio [HR] = 1.237, 95% confidence interval [CI] = 1.049-1.460; HOS: HR = 1.727, 95% CI = 1.405-2.124; HPS: HR = 3.602, 95% CI = 1.912-6.787); and low occupational stress (LOS) and low personal strain (LPS) were protective factors (LOS: HR = 0.366, 95% CI = 0.173-0.776; LPS: HR = 0.490, 95% CI = 0.262-0.919) for NAFLD in the entire police cohort. HOS and HPS remained robust among traffic police.HOS and HPS were independent predictors for the development of NAFLD in a Chinese police population. Additional future prospective investigations are warranted to validate our findings.

  12. Barnehagelærere og stamming: Erfaringer og oppfatninger.

    OpenAIRE

    Vernang, Daniel

    2016-01-01

    Bacheloroppgave, barnehagelærerutdanning, 2016. Norsk: I denne bacheloroppgaven tar jeg opp temaet stamming i barnehagen. Erfaringene og oppfatningene til barnehagelærere er det som blir lagt fokus på, i lys av stamming hos barnehagebarn. Problemstillingen er hvordan erfarer og oppfatter barnehagelærere stamming hos barnehagebarn. For å få svar på dette, har tre barnehagelærere blitt intervjuet. På bakgrunn av intervjuet, består analysen av følgene temaer: Kunnskap om stamming, samarbei...

  13. EFEKTIFITAS HARD DAN SOFT OCCLUSAL SPLINT PADA GANGGUAN SENDI TEMPOROMANDIBULA (Kajian klinis pada seri kasus berdasarkan keluhan nyeri sendi temporomandibula)

    OpenAIRE

    R.A Donna Pratiwi; Laura Susanti Himawan; Roselani W. Odang; Djaja Soeminta

    2015-01-01

    Occlusal splint is commonly used for treatment of the temporomandibular joint disorder (TMD). It can be made of hard and soft material. Hard occlusal splint (HOS) which was known earlier had been recognized more effective than soft occlusal splint (SOS) which recently gained some popularity. This clinical study based on case series was to determined which type of occlusal splint was more effective for TMD. This study involved 20 subjects and they were divided into HOS and SOS group with 10 su...

  14. Psyken er en grænseflade

    DEFF Research Database (Denmark)

    Hoffmeyer, Jesper

    2011-01-01

    En computer er i sig selv blot et stykke mekanik. Det afgørende sker i mødet mellem maskinen, mennesker og fællesskaber: på grænsefladen. Præcis som hos levende væsner......En computer er i sig selv blot et stykke mekanik. Det afgørende sker i mødet mellem maskinen, mennesker og fællesskaber: på grænsefladen. Præcis som hos levende væsner...

  15. Identifying depression among adolescents using three key questions

    DEFF Research Database (Denmark)

    Haugen, Wenche; Haavet, Ole Rikard; Sirpal, Manjit Kaur

    2016-01-01

    Depression rammer mange voksne mennesker. Dette studie, som er omtalt i BMJ, viser, at et spørgeskema med blot tre spørgsmål ret præcist kan identificere voksne med depression. Undersøgelsen viser også, at de samme spørgsmål med fordel kan stilles verbalt ved diagnosticering af depression hos unge...... mennesker. Studiet ledsages af en redaktionel kommentar, der understreger betydningen af diagnosticering af depression hos mennesker. Mange unge har kun sjældent kontakt med deres praktiserende læge. Derfor kan mange gå i lang tid med depression, uden at det bliver opdaget og behandlet. De tre enkle...... spørgsmål, der kredser om interesse (eller mangel på interesse) for daglige aktiviteter og følelser som nedtrykthed eller håbløshed, kan være et godt pejlemærke for evt. depression hos unge, som ellers let kan blive overset....

  16. Barn og diabetes type 1

    OpenAIRE

    Ramstad, Marte Elise; Sagbakken, Sina Bekkelund

    2017-01-01

    Bacheloroppgave sykepleie, 2017 Bakgrunn: Vi har valgt denne problemstillingen fordi diabetes type 1 er svært utbredt hos barn i Norge. Videre har vi lite erfaringer med barn og ønsket å lære mer om denne pasientgruppen. Vi ønsket videre å se på hvordan vi kan undervise og veilede for å gi god og hensiktsmessig sykepleie til barn og deres familier. Hensikt: Finne ut hvordan sykepleier kan fremme egenomsorg hos barn med diabetes gjennom veiledning og undervisning. Dette er noe som sykepl...

  17. A genetic Assay of Three Patients in the Same Family with Holt-Oram Syndrome; a Case Report

    Directory of Open Access Journals (Sweden)

    Reza Ebrahimzadeh-Vesal

    2013-10-01

    Full Text Available Holt-Oram syndrome (HOS is a developmental disorder inherited in an autosomal-dominant pattern. Affected organs are the heart and forelimbs with upper extremity skeletal defects and congenital heart malformation. In this study we present three cases of HOS in the same family. In one of these three individuals we detected a transition of C to T (CTG-GTT, V205V in exon 7 of the TBX5 gene. This nucleotide change causes no amino acid change and potential pathologic effects remain unknown.

  18. Når sproget gør modstand

    DEFF Research Database (Denmark)

    Sundahl Olsen, Lone

    2010-01-01

    For de fleste danske børn går udviklingen af sprog og generelle kommunikative færdigheder let. Hos nogle børn forløber den sproglige udvikling dog langsomt, eller tilegnelsen af vigtige sproglige færdigheder udebliver helt.......For de fleste danske børn går udviklingen af sprog og generelle kommunikative færdigheder let. Hos nogle børn forløber den sproglige udvikling dog langsomt, eller tilegnelsen af vigtige sproglige færdigheder udebliver helt....

  19. Du er god nok! Litteraturstudie om tilrettelegging av mestring for elever med dysleksi.

    OpenAIRE

    Loktu, Thea Amanda Hansen

    2017-01-01

    Bacheloroppgave, grunnskolelærerutdanning, 2017. Norsk: Temaet for oppgaven er mestring og dysleksi og omhandler hvorfor og til dels hvordan en særlig skal legge til rette for mestring hos elever med dysleksi. Oppgaven er fundert i både et samfunnsmessigperspektiv og et individperspektiv. Bacheloren søker å finne de momentene som påvirker læring for denne gruppen, med fokus på det helhetlige mennesket. Problemstillingen lyder slik: Hvorfor legge særlig til rette for mestring hos elever ...

  20. Multicenter Analysis of Midterm Clinical Outcomes of Arthroscopic Labral Repair in the Hip: Minimum 5-Year Follow-up.

    Science.gov (United States)

    Hevesi, Mario; Krych, Aaron J; Johnson, Nick R; Redmond, John M; Hartigan, David E; Levy, Bruce A; Domb, Benjamin G

    2018-02-01

    The technique of hip arthroscopic surgery is advancing and becoming more commonly performed. However, most current reported results are limited to short-term follow-up, and therefore, the durability of the procedure is largely unknown. To perform a multicenter analysis of mid-term clinical outcomes of arthroscopic hip labral repair and determine the risk factors for patient outcomes. Cohort study; Level of evidence, 3. Prospectively collected data of primary hip arthroscopic labral repair performed at 4 high-volume centers between 2008 and 2011 were reviewed retrospectively. Patients were assessed preoperatively and postoperatively with the visual analog scale (VAS), modified Harris Hip Score (mHHS), and Hip Outcome Score-Sports-Specific Subscale (HOS-SSS) at a minimum of 5 years' follow-up. Factors including age, body mass index (BMI), Tönnis grade, and cartilage grade were analyzed in relation to outcome scores, and revision rates were determined. Failure was defined as subsequent ipsilateral hip surgery, including revision arthroscopic surgery and open hip surgery. A total of 303 patients (101 male, 202 female) with a mean age of 32.0 years (range, 10.7-58.9 years) were followed for a mean of 5.7 years (range, 5.0-7.9 years). Patients achieved mean improvements in VAS of 3.5 points, mHHS of 20.1 points, and HOS-SSS of 29.3 points. Thirty-seven patients (12.2%) underwent revision arthroscopic surgery, and 12 (4.0%) underwent periacetabular osteotomy, resurfacing, or total hip arthroplasty during the study period. Patients with a BMI >30 kg/m 2 had a mean mHHS score 9.5 points lower and a mean HOS-SSS score 15.9 points lower than those with a BMI ≤30 kg/m 2 ( P 35 years at surgery had a mean mHHS score 4.5 points lower and a HOS-SSS score 6.7 points lower than those aged ≤35 years ( P = .03). Patients with Tönnis grade 2 radiographs demonstrated a 12.5-point worse mHHS score ( P = .02) and a 23.0-point worse HOS-SSS score ( P SSS scores after arthroscopic

  1. Health observatories in iran.

    Science.gov (United States)

    Rashidian, A; Damari, B; Larijani, B; Vosoogh Moghadda, A; Alikhani, S; Shadpour, K; Khosravi, A

    2013-01-01

    The Islamic Republic of Iran, in her 20 year vision by the year 2025, is a developed country with the first economic, scientific and technological status in the region, with revolutionary and Islamic identity, inspiring Islamic world, as well as effective and constructive interaction in international relations. Enjoying health, welfare, food security, social security, equal opportunities, fair income distribution, strong family structure; to be away from poverty, corruption, and discrimination; and benefiting desirable living environment are also considered out of characteristics of Iranian society in that year. Strategic leadership towards perceived vision in each setting requires restrictive, complete and timely information. According to constitution of National Institute for Health Researches, law of the Fifth Development Plan of the country and characteristics of health policy making, necessity of designing a Health Observatory System (HOS) was felt. Some Principles for designing such system were formulated by taking following steps: reviewing experience in other countries, having local history of the HOS in mind, superior documents, analysis of current production and management of health information, taking the possibilities to run a HOS into account. Based on these principles, the protocol of HOS was outlined in 3 different stages of opinion poll of informed experts responsible for production on management of information, by using questionnaires and Focus Group Discussions. The protocol includes executive regulations, the list of health indicators, vocabulary and a calendar for periodic studies of the community health situation.

  2. High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F2α concentrations relative to a control high-oleic acid meal: a randomized controlled trial.

    Science.gov (United States)

    Purcell, Robert; Latham, Sally H; Botham, Kathleen M; Hall, Wendy L; Wheeler-Jones, Caroline P D

    2014-10-01

    Eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplementation has beneficial cardiovascular effects, but postprandial influences of these individual fatty acids are unclear. The primary objective was to determine the vascular effects of EPA + DHA compared with DHA only during postprandial lipemia relative to control high-oleic acid meals; the secondary objective was to characterize the effects of linoleic acid-enriched high-fat meals relative to the control meal. We conducted a randomized, controlled, double-blind crossover trial of 4 high-fat (75-g) meals containing 1) high-oleic acid sunflower oil (HOS; control), 2) HOS + fish oil (FO; 5 g EPA and DHA), 3) HOS + algal oil (AO; 5 g DHA), and 4) high-linoleic acid sunflower oil (HLS) in 16 healthy men (aged 35-70 y) with higher than optimal fasting triacylglycerol concentrations (mean ± SD triacylglycerol, 1.9 ± 0.5 mmol/L). Elevations in triacylglycerol concentration relative to baseline were slightly reduced after FO and HLS compared with the HOS control (P acids after a mixed meal was inhibited after AO (Δ 0-3 h, P DHA-rich fish oil compared with DHA-rich AO, but these differences were not associated with consistent effects on postprandial vascular function or lipemia. More detailed analyses of polyunsaturated fatty acid-derived lipid mediators are required to determine possible divergent functional effects of single meals rich in either DHA or EPA. This trial was registered at clinicaltrials.gov as NCT01618071.

  3. Different People in Different Places - Secondary School Students' Knowledge About History of Science

    Science.gov (United States)

    Gandolfi, Haira Emanuela

    2018-05-01

    This article presents the results of an exploratory study of students' knowledge about scientists and countries' contributions to science, aiming at answering two research questions: "In which ways are students aware of the history of scientific development carried out by different people in different places of the world? What can be influencing and shaping their awareness?" Thus, this study aimed at depicting students' knowledge about History of Science (HOS), focusing on what they know about science being done by people and communities from different parts of the world and on how this knowledge is constructed through their engagement with school science. An exploratory research was carried out at two multicultural state secondary schools in London, UK, involving 200 students aged 12-15 (58.5% girls, 41.5% boys) and five science teachers. The method involved an initial exploration of students' knowledge about HOS through an open-ended survey, followed by classroom-based observations and semi-structured interviews with the participants. Results showed a disconnection between remembering scientists and knowing about their work and background, hinting at an emphasis on illustrative and decontextualised approaches towards HOS. Additionally, there was a lack of diversity in these students' answers in terms of gender and ethnicity when talking about scientists and countries in science. These findings were further analysed in relation to their implications for school science and for the fields of HOS, science education and public perception of science.

  4. Case report - curved femoral osteotomy for management of medial patellar luxation

    DEFF Research Database (Denmark)

    Allpass, Maja; Miles, James Edward

    2015-01-01

    Medial patellaluxation kan forårsages af femoral varus hos hund. Førhen har patienter med excessiv femoralvarus været korrigeret ved en lateralt placeret femoral kile-ostektomi. Her præsenteres en case, hvor en buet osteotomi blev anvendt til behandling af medial patellaluxation.......Medial patellaluxation kan forårsages af femoral varus hos hund. Førhen har patienter med excessiv femoralvarus været korrigeret ved en lateralt placeret femoral kile-ostektomi. Her præsenteres en case, hvor en buet osteotomi blev anvendt til behandling af medial patellaluxation....

  5. Kommunikationssvårigheter inom autismspektrumtillstånd : En fallstudie om användningen av det alternativa kommunikationsverktyget PECS

    OpenAIRE

    Larsson, Beatrice

    2014-01-01

    Syftet med denna studie är att undersöka användningen av det alternativa kommunikationsverktyget PECS (Picture Exchange Communication System), som är vanligt förekommande hos personer inom autismspektrumtillstånd (ASD). Hos människor inom ASD är det vanligt med kommunikationssvårigheter samt utpräglade beteendeproblem. Genom intervjuer med skola, habilitering och boende har PECS studerats utifrån olika aspekter. Hur går inlärningen till? Hur används verktyget i det dagliga livet? Vilka för- o...

  6. Læring og refleksion

    DEFF Research Database (Denmark)

    Wahlgren, B.; Rattleff, Pernille; Høyrup, S.

    State of the art inden for forskning om læring på arbejdspladsen samt gennemgang af læringsteori og refleksionsbegrebet hos Dewey, Dreyfus, Schön, Argyris, Kolb, Jarvis, Mezirow og Brookfield. Afsluttes med diskussion af syntetiseret model for læring på arbejdspladsen.......State of the art inden for forskning om læring på arbejdspladsen samt gennemgang af læringsteori og refleksionsbegrebet hos Dewey, Dreyfus, Schön, Argyris, Kolb, Jarvis, Mezirow og Brookfield. Afsluttes med diskussion af syntetiseret model for læring på arbejdspladsen....

  7. La communication animale selon Ğāḥiz, à travers son œuvre Kitāb al-Ḥayawān

    DEFF Research Database (Denmark)

    Aarab, Ahmed; Provencal, Philippe

    2016-01-01

    En præsentation af en af de tidligste analyser af kommunikation mellem individerne hos forskellige dyrearter. Denne analyse findes i værket fra det 9. århundrede Kitāb al-Ḥayawān skrevet af al-Ğāḥiz.......En præsentation af en af de tidligste analyser af kommunikation mellem individerne hos forskellige dyrearter. Denne analyse findes i værket fra det 9. århundrede Kitāb al-Ḥayawān skrevet af al-Ğāḥiz....

  8. Menneskets dannelse

    DEFF Research Database (Denmark)

    Eriksson, Birgit

    2007-01-01

    "Menneskets dannelse - mellem kunst og natur" handler om, hvordan opfattelsen af menneskets identitet og dannelse ændrede sig i sidste del af oplysningstiden. Birgit Eriksson undersøger her, hvordan ændringerne kom til udtryk hos Goethe, som i sit alsidige forfatterskab konfronterede mange af...... tidens vigtigste udfordringer inden for filosofi, videnskab og kunst. Influeret af erfaringerne fra sine naturstudier fremstillede han i romanen Wilhelm Meisters Læreår mennesket som modsætningsfyldt, foranderligt og påvirkeligt. Hos Goethe var mennesket ikke et stærkt og autonomt centrum, men dybt...

  9. Degraded iota-carrageenan can induce apoptosis in human osteosarcoma cells via the Wnt/β-catenin signaling pathway.

    Science.gov (United States)

    Jin, Zhe; Han, Ya-Xin; Han, Xiao-Rui

    2013-01-01

    Osteosarcoma (OS) is a high-grade malignant bone tumor. Therefore, using both in vitro and in vivo assays, the effects of degraded iota-Carrageenan (ι-CGN) on a human osteosarcoma cell line, HOS, were examined. Degraded ι-CGN was observed to induce apoptosis and G(1) phase arrest in HOS cells. Moreover, degraded ι-CGN suppressed tumor growth in established xenograft tumor models. Accordingly, the survival rate of these mice was significantly higher than that of mice bearing tumors treated with native ι-CGN or PBS. In addition, the formation of intratumoral microvessels was inhibited following treatment with degraded ι-CGN. In Western blot assays, degraded ι-CGN was found to inhibit the Wnt/β-catenin signaling pathway. Overall, these studies demonstrate the antitumor activity of degraded ι-CGN toward the OS cell line, HOS. Moreover, valuable insight into the mechanisms mediated by degraded ι-CGN was obtained, potentially leading to the identification of novel treatments for OS. However, additional studies are needed to confirm these results in other cell types, particularly in human umbilical vein endothelial cells.

  10. Direct-access to abdominal ultrasonic investigation from general practice-the role in earlier cancer diagnosis

    DEFF Research Database (Denmark)

    Ingeman, Mads Lind; Ormstrup, Tina E; Vedsted, Peter

    2015-01-01

    at diagnosticere kræft i bughulen, fordi de første tegn tit er uspecifikke og svage. Formålet med dette studie var at beskrive de praktiserende læges brug af muligheden for direkte adgang til ultralydsscanning af bughulen og at undersøge udbredelsen af kræft hos de henviste patienter. De deltagende læger havde...... mulighed for enten at henvise patienterne direkte til ultralydsskanning eller via en normal venteliste. Knap 60 % af patienterne blev henvist via den direkte adgang, og 2,7 % af alle henviste patienter fik konstateret kræft i løbet af de første seks måneder efter skanningen. Skanningen gav direkte mistanke...... om kræft hos 57,9 % af kræftpatienterne, og 90 % af disse cancere blev fundet hos patienter, som blev henvist via den direkte adgang. Resultaterne var ikke signifikante, men de tyder dog på, at de praktiserende læger generelt vælger at henvise patienter med en større kræftrisiko til den direkte...

  11. Association of GPs' risk attitudes, level of empathy, and burnout status with PSA testing in primary care

    DEFF Research Database (Denmark)

    Pedersen, Anette F; Carlsen, Anders H; Vedsted, Peter

    2015-01-01

    Denne artikel undersøger, om variationen i raten af PSA-tests mellem alment praktiserende læger kan forklares af psykologiske faktorer som f.eks. lægens risikovillighed. Resultaterne viser, at lægens risikovillighed influerer på raten af PSA-tests. Forfatterne finder blandt andet, at patienter, som...... er registreret hos en læge med mange bekymringer for fejlbehandlinger, har større sandsynlighed for at få taget en PSA-test. Patienter, som er registreret hos en læge, som har en høj tolerance for flertydighed i lægearbejdet, har derimod mindre sandsynlighed for at få foretaget en PSA-test. Patienter......, som er registreret hos en læge med høj tolerance for flertydighed eller en tilbøjelighed til risikobetonet adfærd, har en mindre sandsynlighed for at få gentaget en tidligere normal PSA-test. Undersøgelsen bygger på spørgeskemabesvarelser fra 129 alment solo-praktiserende læger i Region Midtjylland...

  12. Harepest hos jaeger

    DEFF Research Database (Denmark)

    Edfors, Robert; Smith, Birgitte; Lillebaek, Troels

    2010-01-01

    "Rabbit fever" (Francisella Tularensis) is a rare infection in Denmark. It was first described in Denmark in 1987. It is most likely to affect people who come into close contact with infected animals or ticks, such as hunters, butchers and veterinarians. The diagnosis should be suspected in such ......"Rabbit fever" (Francisella Tularensis) is a rare infection in Denmark. It was first described in Denmark in 1987. It is most likely to affect people who come into close contact with infected animals or ticks, such as hunters, butchers and veterinarians. The diagnosis should be suspected...

  13. Syfilis hos gravide

    DEFF Research Database (Denmark)

    Vestergaard, Tine; Ibsen, Hans Henning Windeløv

    2012-01-01

    The incidence of syphilis in Denmark is rising. In 2010, 377 new cases of syphilis were reported, 36 of these cases in women. Since January 1st 2010 all pregnant women are offered an antenatal syphilis test. This resulted in the finding of seven cases of syphilis among pregnant women in 2010....... This article summarises the clinical and serological findings in syphilis and describes the treatment of the disease, with focus on pregnancy and congenital infection....

  14. Hypertension hos gravide

    DEFF Research Database (Denmark)

    Mathiesen, Elisabeth R; Johansen, Marianne; Kamper, Anne Lise

    2009-01-01

    There are four major hypertensive disorders in pregnancy: chronic hypertension, gestational hypertension, preeclampsia and chronic hypertension with superimposed preeclampsia. The indications and efficacy of antihypertensive treatment of the different hypertensive disorders are assessed. Advantages...

  15. Histone deacetylases: revealing the molecular base of dimorphism in pathogenic fungi

    Directory of Open Access Journals (Sweden)

    Alberto Elías-Villalobos

    2015-11-01

    Full Text Available Fungi, as every living organism, interact with the external world and have to adapt to its fluctuations. For pathogenic fungi, such interaction involves adapting to the hostile environment of their host. Survival depends on the capacity of fungi to detect and respond to external stimuli, which is achieved through a tight and efficient genetic control. Chromatin modifications represent a well-known layer of regulation that controls gene expression in response to environmental signals. However, less is known about the chromatin modifications that are involved in fungal virulence and the specific cues and signalling pathways that target chromatin modifications to specific genes. In a recently published study, our research group identified one such regulatory pathway. We demonstrated that the histone deacetylase (HDAC Hos2 is involved in yeast-to-hyphal transition (dimorphism and it is associated with the virulence of the maize pathogen Ustilago maydis, the causative agent of smut disease in corn. Hos2 activates mating-type genes by directly binding to their gene bodies. Furthermore, Hos2 acts downstream of the nutrient-sensing cyclic AMP-Protein Kinase A pathway. We also found that another HDAC, Clr3, contributes to this regulation, possibly in cooperation with Hos2. As a whole, our data suggest that there is a direct link between changes in the environment and acetylation of nucleosomes within certain genes. We propose that histone acetylation is critical to the proper timing and induction of transcription of the genes encoding factors that coordinate changes in morphology with pathogenesis.

  16. Fremtidens produktion - på mikro og nano niveau

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    Der tales seriøst om nanoteknologi som et nyt segment hos produktionsvirksomhederne, og alle kan se, at chip-topologien når nano-dimensioner i løbet af 2003 - 2005. Det er en stor udfordring at skabe det operationelle grundlag for en industriel produktion af mikro-teknologiske produkter. Efterhån......Der tales seriøst om nanoteknologi som et nyt segment hos produktionsvirksomhederne, og alle kan se, at chip-topologien når nano-dimensioner i løbet af 2003 - 2005. Det er en stor udfordring at skabe det operationelle grundlag for en industriel produktion af mikro-teknologiske produkter...

  17. Hvordan håndterer kvinder med reumatoid artrit sygdom, moderskab og arbejdsliv?

    DEFF Research Database (Denmark)

    Feddersen, Helle

    2017-01-01

    . I Studie 2B blev der fortaget deltagerobservationer og efterfølgende interviews i forbindelse med 10 af kvindernes fremmøde i planlagte ambulante sygeplejekonsultationer. Goffmans begrebsapparat vedrørende sociale roller, identitet, stigma, front- og backstage blev anvendt i en abduktiv fortolkning......Baggrund Reumatoid artrit (RA) er en kronisk, inflammatorisk sygdom, der forekommer 3 gange hyppigere hos kvinder end hos mænd. Sygdommen kan medføre hævede, stive og smertende led samt begrænsninger i forhold til fysisk udfoldelse, deltagelse i det sociale liv og nedsat psykisk velvære. Kvinder...

  18. Vold, svensk uro og Henning Mankell

    DEFF Research Database (Denmark)

    Hansen, Kim Toft

    Paperet undersøger den fiktionelle repræsentation af vold hos Henning Mankell med fokus på Innan frosten fra 2002 og filmatiseringen heraf fra 2005, men med fyldige udblik til såvel andre af Mankells fortællinger og ikke mindst sociologiske og filosofiske diskussioner af volden, voldens forstyrre......Paperet undersøger den fiktionelle repræsentation af vold hos Henning Mankell med fokus på Innan frosten fra 2002 og filmatiseringen heraf fra 2005, men med fyldige udblik til såvel andre af Mankells fortællinger og ikke mindst sociologiske og filosofiske diskussioner af volden, voldens...

  19. Effect of testosterone on antler growth in yearling male reindeer

    Directory of Open Access Journals (Sweden)

    Morten Ryg

    1983-05-01

    Full Text Available 1. The effect of exogenous testosterone on ander growth in yearling male reindeer (Rangifer tarandus tarandus was tested. 2. Testosterone (33 mg/kg inhibited antler growth, and in one animal induced cleaning and subsequent casting of the antlers. This animal grew a new set of antlers, which were cleaned at the normal time. 3. During treatment, there was an inverse relationship between peak testosterone levels and antler growth rate. 4. There was no effect of treatment on body weight or food intake. 5. It is concluded that the effects of testosterone on antler growth are qualitatively the same in reindeer as in other deer. However, because high testosterone doses were necessary to produce effects, it is questionable whether this hormone normally is responsible for the cessation of antler growth in reindeer.Virkningen av testosteron på gevirvekst hos ettårige reinbukker.Abstract in Norwegian / Sammendrag: 1. Virkningen av testosteron på gevirvekst hos ett-årige reinbukker (Rangifer tarandus tarandus ble undersøkt. 2. Testosteron (33 mg/kg hemmet gevirveksten, og hos ett dyr førte behandlingen til at geviret ble feiet og deretter felt. Deretter vokste det ut ett nytt gevir, som ble feiet til vanlig tid. 3. Det var en negativ korrelasjon mellom maksimale testosteronnivåer og gevirvekst under behandlingen. 4. Det var ingen effekt på forinntak eller vektutvikling. 5. Det blir konkludert med at virkningen av testosteron på gevirvekst er kvalitativt den samme hos rein som hos andre hjortedyr. Det er likevel tvilsomt om testosteron normalt er ansvarlig for avslutningen av gevirvekst hos rein, fordi store testosterondoser måtte til for å få noen virkning.Testosteronin vaikutus vuodenikåisten urosporojen sarvien kasvuun.Abstract in Finnish / Tiivistelmä: 1. Tutkimuksessa seurattiin ruiskeena annetun testosteronin vaikutusta vuodenikåisten urosporojen (Rangifer tarandus tarandus sarvien kasvuun. 2. Testosteron! (33 mg/kg hidasti sarvien

  20. Heme and non-heme iron transporters in non-polarized and polarized cells

    Directory of Open Access Journals (Sweden)

    Yasui Yumiko

    2010-06-01

    Full Text Available Abstract Background Heme and non-heme iron from diet, and recycled iron from hemoglobin are important products of the synthesis of iron-containing molecules. In excess, iron is potentially toxic because it can produce reactive oxygen species through the Fenton reaction. Humans can absorb, transport, store, and recycle iron without an excretory system to remove excess iron. Two candidate heme transporters and two iron transporters have been reported thus far. Heme incorporated into cells is degraded by heme oxygenases (HOs, and the iron product is reutilized by the body. To specify the processes of heme uptake and degradation, and the reutilization of iron, we determined the subcellular localizations of these transporters and HOs. Results In this study, we analyzed the subcellular localizations of 2 isoenzymes of HOs, 4 isoforms of divalent metal transporter 1 (DMT1, and 2 candidate heme transporters--heme carrier protein 1 (HCP1 and heme responsive gene-1 (HRG-1--in non-polarized and polarized cells. In non-polarized cells, HCP1, HRG-1, and DMT1A-I are located in the plasma membrane. In polarized cells, they show distinct localizations: HCP1 and DMT1A-I are located in the apical membrane, whereas HRG-1 is located in the basolateral membrane and lysosome. 16Leu at DMT1A-I N-terminal cytosolic domain was found to be crucial for plasma membrane localization. HOs are located in smooth endoplasmic reticulum and colocalize with NADPH-cytochrome P450 reductase. Conclusions HCP1 and DMT1A-I are localized to the apical membrane, and HRG-1 to the basolateral membrane and lysosome. These findings suggest that HCP1 and DMT1A-I have functions in the uptake of dietary heme and non-heme iron. HRG-1 can transport endocytosed heme from the lysosome into the cytosol. These localization studies support a model in which cytosolic heme can be degraded by HOs, and the resulting iron is exported into tissue fluids via the iron transporter ferroportin 1, which is

  1. Psychosocial Stress Related to the Loss of a Close Relative the Year Before or During Pregnancy and Risk of Preeclampsia

    DEFF Research Database (Denmark)

    László, Krisztina D; Qin, Liu Xiao; Svensson, Tobias

    2013-01-01

    Mange studier peger på, at stress hos den gravide kan påvirke udfaldet af graviditeten. Dette studie undersøger, om sorg hos den gravide øger risikoen for dødfødsel. Studiet er baseret på en landsdækkende svensk undersøgelse, som inkluderer data fra knap 3 millioner fødsler i perioden 1973......-2006. Demografiske, helbredsmæssige og graviditetsrelaterede oplysninger såvel som information om dødsfald i den gravides nærmeste familie blev trukket fra landsdækkende registre og koblet via cpr-numre. I alt 11.071 dødfødsler (svarende til 3,8 dødfødsler for 1000 fødsler) blev registreret i kohorten. Resultaterne...... tab hos moderen og dødfødsel. Der synes heller ikke at være forskel på, om dødsfaldet var ventet eller uventet. Tab af et nært familiemedlem er en af de alvorligste kilder til stress, og fremtidige studier bør undersøge, om mindre alvorlige og mere udbredte typer af stress også kan medvirke til at øge...

  2. On the computation of the higher-order statistics of the channel capacity over generalized fading channels

    KAUST Repository

    Yilmaz, Ferkan

    2012-12-01

    The higher-order statistics (HOS) of the channel capacity μn=E[logn (1+γ end)], where n ∈ N denotes the order of the statistics, has received relatively little attention in the literature, due in part to the intractability of its analysis. In this letter, we propose a novel and unified analysis, which is based on the moment generating function (MGF) technique, to exactly compute the HOS of the channel capacity. More precisely, our mathematical formalism can be readily applied to maximal-ratio-combining (MRC) receivers operating in generalized fading environments. The mathematical formalism is illustrated by some numerical examples focusing on the correlated generalized fading environments. © 2012 IEEE.

  3. Nyt koncept forebygger sundhedsproblemer i mælkeproduktionen

    DEFF Research Database (Denmark)

    Rothmann Holm, Janne

    2017-01-01

    Overvågning: Ved brug af HACCP konceptet kan landmænd opdage og løse sundhedsproblemer hos køer på et tidligt tidspunkt. I EU projektet GplusE arbejder man på at tilpasse HACCP konceptet til brug for overvågning af sundheden i mælkeproduktionen.......Overvågning: Ved brug af HACCP konceptet kan landmænd opdage og løse sundhedsproblemer hos køer på et tidligt tidspunkt. I EU projektet GplusE arbejder man på at tilpasse HACCP konceptet til brug for overvågning af sundheden i mælkeproduktionen....

  4. VISUALISERINGSTAVLA : Visualisering av Kanban boards

    OpenAIRE

    Y. F. Sam, Adam

    2013-01-01

    Hos många företag används whiteboards för att visualisera arbetsprocessen. En vanlig metodik för detta är så kallade Kanban boards, ett system av tabeller och lappar för att indikera olika avvikelser eller moment i projekt med datum och annan relevant information. Företag kan även välja att använda en mjukvara som simulerar samma metodik, ett exempel på detta är så kallade Elektroniska kanban boards. I detta arbete har båda dessa metoder (whiteboard samt en digital lösning) observerats hos tr...

  5. On the computation of the higher-order statistics of the channel capacity over generalized fading channels

    KAUST Repository

    Yilmaz, Ferkan; Alouini, Mohamed-Slim

    2012-01-01

    The higher-order statistics (HOS) of the channel capacity μn=E[logn (1+γ end)], where n ∈ N denotes the order of the statistics, has received relatively little attention in the literature, due in part to the intractability of its analysis. In this letter, we propose a novel and unified analysis, which is based on the moment generating function (MGF) technique, to exactly compute the HOS of the channel capacity. More precisely, our mathematical formalism can be readily applied to maximal-ratio-combining (MRC) receivers operating in generalized fading environments. The mathematical formalism is illustrated by some numerical examples focusing on the correlated generalized fading environments. © 2012 IEEE.

  6. Kan adoption hjælpe de glemte børn?

    DEFF Research Database (Denmark)

    Christoffersen, Mogens

    2008-01-01

    Er adoption bedre end opvækst på en moderne døgninstitution eller hos en plejefamilie? I et velfærdssamfund som det danske med lang tradition for fokus på, hvordan det går de anbragte børn, er dette et centralt spørgsmål.......Er adoption bedre end opvækst på en moderne døgninstitution eller hos en plejefamilie? I et velfærdssamfund som det danske med lang tradition for fokus på, hvordan det går de anbragte børn, er dette et centralt spørgsmål....

  7. Reproducibility, validity, and responsiveness of the hip outcome score in patients with end-stage hip osteoarthritis.

    Science.gov (United States)

    Naal, Florian D; Impellizzeri, Franco M; von Eisenhart-Rothe, Rüdiger; Mannion, Anne F; Leunig, Michael

    2012-11-01

    To evaluate reproducibility, validity, and responsiveness of the Hip Outcome Score (HOS) in patients with end-stage hip osteoarthritis. In a cohort of 157 consecutive patients (mean age 66 years; 79 women) undergoing total hip replacement, the HOS was tested for the following measurement properties: feasibility (percentage of evaluable questionnaires), reproducibility (intraclass correlation coefficient [ICC] and standard error of measurement [SEM]), construct validity (correlation with the Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC], Oxford Hip Score [OHS], Short Form 12 health survey, and University of California, Los Angeles activity scale), internal consistency (Cronbach's alpha), factorial validity (factor analysis), floor and ceiling effects, and internal and external responsiveness at 6 months after surgery (standardized response mean and change score correlations). Missing items occurred frequently. Five percent to 6% of the HOS activities of daily living (ADL) subscales and 20-32% of the sport subscales could not be scored. ICCs were 0.92 for both subscales. SEMs were 1.8 points (ADL subscale) and 2.3 points (sport subscale). Highest correlations were found with the OHS (r = 0.81 for ADL subscale and r = 0.58 for sport subscale) and the WOMAC physical function subscale (r = 0.83 for ADL subscale and r = 0.56 for sport subscale). Cronbach's alpha was 0.93 and 0.88 for the ADL and sport subscales, respectively. Neither unidimensionality of the subscales nor the 2-factor structure was supported by factor analysis. Both subscales showed good internal and external responsiveness. The HOS is reproducible and responsive when assessing patients with end-stage hip osteoarthritis in whom the items are relevant. However, based on the large proportion of missing data and the findings of the factor analysis, we cannot recommend this questionnaire for routine use in this target group. Copyright © 2012 by the American College of Rheumatology.

  8. On the computation of the higher order statistics of the channel capacity for amplify-and-forward multihop transmission

    KAUST Repository

    Yilmaz, Ferkan; Tabassum, Hina; Alouini, Mohamed-Slim

    2014-01-01

    Higher order statistics (HOS) of the channel capacity provide useful information regarding the level of reliability of signal transmission at a particular rate. In this paper, we propose a novel and unified analysis, which is based on the moment-generating function (MGF) approach, to efficiently and accurately compute the HOS of the channel capacity for amplify-and-forward (AF) multihop transmission over generalized fading channels. More precisely, our easy-to-use and tractable mathematical formalism requires only the reciprocal MGFs of the transmission hop signal-to-noise ratio (SNR). Numerical and simulation results, which are performed to exemplify the usefulness of the proposed MGF-based analysis, are shown to be in perfect agreement. © 2013 IEEE.

  9. Robust functional statistics applied to Probability Density Function shape screening of sEMG data.

    Science.gov (United States)

    Boudaoud, S; Rix, H; Al Harrach, M; Marin, F

    2014-01-01

    Recent studies pointed out possible shape modifications of the Probability Density Function (PDF) of surface electromyographical (sEMG) data according to several contexts like fatigue and muscle force increase. Following this idea, criteria have been proposed to monitor these shape modifications mainly using High Order Statistics (HOS) parameters like skewness and kurtosis. In experimental conditions, these parameters are confronted with small sample size in the estimation process. This small sample size induces errors in the estimated HOS parameters restraining real-time and precise sEMG PDF shape monitoring. Recently, a functional formalism, the Core Shape Model (CSM), has been used to analyse shape modifications of PDF curves. In this work, taking inspiration from CSM method, robust functional statistics are proposed to emulate both skewness and kurtosis behaviors. These functional statistics combine both kernel density estimation and PDF shape distances to evaluate shape modifications even in presence of small sample size. Then, the proposed statistics are tested, using Monte Carlo simulations, on both normal and Log-normal PDFs that mimic observed sEMG PDF shape behavior during muscle contraction. According to the obtained results, the functional statistics seem to be more robust than HOS parameters to small sample size effect and more accurate in sEMG PDF shape screening applications.

  10. Prada postulaat = Prada Postulate / Martin Melioranski

    Index Scriptorium Estoniae

    Melioranski, Martin

    2002-01-01

    Hollandi arhitektide Rem Koolhaasi ja Ole Scheereni (Office for Metropolitan Architecture) projekteeritud Prada kauplusest SoHos New Yorgis. Infotehnoloogia: R. Koolhaas ja Markus Schaefer (AMO-Information technology). 13 ill.

  11. Nogle argumentationsgange hos Habermas

    DEFF Research Database (Denmark)

    Dupont, Søren

    1985-01-01

    Artiklen forholder sig til væsentlige begreber fra Habermas' teori om den kommunikative handlen.......Artiklen forholder sig til væsentlige begreber fra Habermas' teori om den kommunikative handlen....

  12. Urogenital tuberkulose hos danskere

    DEFF Research Database (Denmark)

    Almasi, Charlotte Elberling; Holm, Mette; Meyhoff, Hans-Henrik

    2002-01-01

    Extrapulmonary tuberculosis is rare in natives of Denmark, who are not exposed to risk factors, such as homelessness and drug or alcohol abuse. Two patients diagnosed with advanced urogenital tuberculosis are reported.......Extrapulmonary tuberculosis is rare in natives of Denmark, who are not exposed to risk factors, such as homelessness and drug or alcohol abuse. Two patients diagnosed with advanced urogenital tuberculosis are reported....

  13. Executive Summary

    DEFF Research Database (Denmark)

    Elf, Nikolaj Frydensbjerg

    2017-01-01

    Rekvireret forskningsrapport for Undervisningsministeriet (UVM) som afrapporterer forundersøgelsesfasen for danskfagets vedkommende i projekt Kvalitet i dansk og matematik. Har været til gennemsyn inden udgivelse hos UVM....

  14. Tv-nyheder fra hjemlandet – integration eller ghettoisering? Om transnationalisme og nyhedsforbrug

    Directory of Open Access Journals (Sweden)

    Connie Carøe Christiansen

    2001-09-01

    Full Text Available Hvilken rolle spiller medierne i hverdagslivet blandt etniske minoriteter i Danmark? Lidt firkantet kan man spørge: er mennesker af anden etnisk oprindelse mere integrerede, når de foretrækker dansk produceret fjern- syn, end når de foretrækker oprindelseslandets tv? Kultursociologen Connie Carøe Christiansen har i denne artikel trukket nogle af pointerne op fra en undersøgelse, som Danmarks Radio bestilte hos Socialforsk- ningsinstituttet om netop nogle af ovenstående spørgsmål. Carøe, en af rapportens hovedforfattere, analyserer medieforbruget hos etniske mino- riteter i Danmark i lyset af diskussioner om multikulturalisme og social integration. Artiklen er således inspireret af diskussioner om transnationa- lisme og diaspora-identiteter.

  15. Rapport for Center for Vildtsundhed 1. halvår 2012

    DEFF Research Database (Denmark)

    Chriél, Mariann; Enemark, Heidi L.; Therkildsen, Ole Roland

    for vurderingen af parasitbelastningen hos raske ederfugle. Redemateriale til undersøgelse af Pasteurella multocida, der forårsager udbrud af fjerkrækolera, fortsættes i et specialestudie af de dyrkbare bakterier. Med henblik på kortlægning af rævens dværgbændelorm (Echinococcus multilocularis) hos mårhund og ræv...... Danmark siden 2000, og det er første gang bændelormen er påvist i jyske ræve. Echinococcus multilocularis kan smitte til mennesker, hvor de i larvestadiet angriber leveren, hvilket kan have fatale følger, så det er vigtigt, at folk er opmærksomme på risikoen og tager deres forbehold. Mennesker smittes...

  16. Composite materials for aircraft structures

    National Research Council Canada - National Science Library

    Baker, A. A; Dutton, Stuart; Kelly, Donald

    2004-01-01

    ... materials for aircraft structures / Alan Baker, Stuart Dutton, and Donald Kelly- 2nd ed. p. cm. - (Education series) Rev. ed. of: Composite materials for aircraft structures / edited by B. C. Hos...

  17. Rituals to free the spirit – or what the cremation pyre told

    DEFF Research Database (Denmark)

    Nielsen, Karen Høilund

    2009-01-01

    Sammenligning og diskussion af begravelsesriterne på gravpladsen Lindholm Høje (400-800 e.kr.) og skriftlige overleveringer om brandbegravelser og ledsagende ritualer, herunder hos Ibn Fadlan og i Beowulf-kvadet....

  18. Using Expert Panel Data to Guide Youth Agricultural Safety and Health Training Resources in the US

    Directory of Open Access Journals (Sweden)

    Andrew J. Mann

    2017-01-01

    Full Text Available The US Department of Labor (US DOL oversees the Agricultural Hazardous Occupations Orders (AgHOs, which identifies specific tasks that youth are prohibited from performing for hire on American farms and ranches. An educational exemption from this public policy is currently in place that allows youth, 14–15 years old, to complete a certification program prior to engaging in agricultural work involving tractors and machinery. However, limited guidance is provided in the legislation regarding the format or content of the tractor and machinery certification exemption. Four AgHOs (tractor and machinery studies were identified and included in this meta-analysis publication. The research goals of this analysis were to determine basic trends of learning outcomes, and identify educational content to be delivered as a result of these studies. Within each of the four studies, expert panels were used to identify educational learning outcomes. The analysis revealed that 48.0% (n = 184 of all learning outcome items fell within the Tractor-based (Tractor learning outcome category, 29.8% (n = 114 within General Safety and Health (General, and 22.2% (n = 85 of items in the Machinery-based (Machinery category. Ultimately, sound educational methods and understanding of fundamental student competence are essential components for any training program, including youth who complete AgHOs tractor and machinery certification programs.

  19. Functional analysis of the novel TBX5 c.1333delC mutation resulting in an extended TBX5 protein

    Directory of Open Access Journals (Sweden)

    Ekman-Joelsson Britt-Marie

    2008-10-01

    Full Text Available Abstract Background Autosomal dominant Holt-Oram syndrome (HOS is caused by mutations in the TBX5 gene and is characterized by congenital heart and preaxial radial ray upper limb defects. Most of the TBX5 mutations found in patients with HOS cause premature truncation of the primary TBX5 transcript. TBX5 missense mutations alter the three-dimensional structure of the protein and result in failed nuclear localization or reduced binding to target DNA. In this study we present our functional analyses of the novel and unusual c.1333delC mutation found in a patient with classical HOS. Methods The functional impact of this novel mutation was assessed by investigating the intracellular localization of the resulting TBX5 protein and its ability to activate the expression of its downstream target ANF. Results The deletion of the cytosine is the first TBX5 frameshift mutation predicted to result in an elongated TBX5 protein with 74 miscoding amino acids and 62 supernumerary C-terminal amino acids. The c.1333delC mutation affects neither the nuclear localization, nor its colocalization with SALL4, but severely affects the activation of the ANF promoter. Conclusion The mutation c.1333delC does not locate within functional domains, but impairs the activation of the downstream target. This suggests that misfolding of the protein prevents its biological function.

  20. Arthroscopic release using F and C method versus conventional open release method in the treatment of gluteal muscle contracture: a comparative study.

    Science.gov (United States)

    Rai, Saroj; Jin, Shengyang; Meng, Chunqing; Chaudhary, Nabin; Tamang, Nira; Wang, Xiaohong; Liu, Xianzhe; Wang, Hong; Yang, Shuhua

    2017-03-16

    Gluteal muscle contracture (GMC), a debilitating disease, usually starts in early childhood after variable dose of injections around the buttock, if left untreated it worsens gradually and persists throughout the life. Because the disease mostly affects adolescents and adults, there is always an aesthetic concerns. Purposeof the study was to introduce the arthroscopic F and C method of GMC release, and to compare its clinical efficiency with conventional open surgery in terms of clinical outcome, rate of complications, patient's satisfactions, and recurrence. Between Jan 2013 and July 2015, 75 patients received an arthroscopic release with F and C release method and 71 patients received conventional open release of GMC. Primary surgeries in 16 years or older patients were included in the study. Two groups were compared clinically using Hip Outcome Scores - Activities of Daily Living Subscale (HOS-ADL), Hip Outcome Scores - Sports Subscale (HOS-Sports), Visual Analogue Scale (VAS), and Ye et al. evaluation criteria. No statistically significant differences were observed in Hip Outcome Scores - Activities of Daily Living Subscale (HOS-ADL) (P = 0.078), Hip Outcome Scores - Sports Subscale (HOS-Sports) (P = 0.340), and Visual Analogue Scale (VAS) (P = 0.524) between the two groups. 74 (98.7%) patients in the arthroscopic surgery group had good to excellent results, whereas 69 (97.1%) patients in the conventional open surgery group had good to excellent results (P = 0.727). No statistically significant difference was observed in recurrence rate (P = 0.612). Statistically significant differences were observed in incision length, use of post-operative analgesia, post-operative off-bed activity, and hospital stay. Complications were significantly higher in the conventional open surgery group (n = 21) than in the arthroscopic surgery group (n = 10) (P = 0.016). More importantly, cosmetic satisfaction was 100% in arthroscopic release group

  1. Outcomes of Revision Hip Arthroscopy: 2-Year Clinical Follow-up.

    Science.gov (United States)

    Gupta, Asheesh; Redmond, John M; Stake, Christine E; Dunne, Kevin F; Hammarstedt, Jon E; Domb, Benjamin G

    2016-05-01

    To evaluate clinical outcomes, pain, and patient satisfaction following revision hip arthroscopy with a minimum 2-year follow-up. From April 2008 to October 2011, data were prospectively collected on all patients undergoing revision hip arthroscopy. All patients were assessed pre- and postoperatively with 4 patient-reported outcome (PRO) measures: the modified Harris hip score (mHHS), nonarthritic hip score (NAHS), hip outcome score-activities of daily living (HOS-ADL), and hip outcome score-sport-specific subscales (HOS-SSS). Pain was estimated on the visual analog scale (VAS). Patient satisfaction was measured on a scale from 0 to 10. The number of patients who underwent subsequent revision arthroscopy or total hip arthroplasty during the study period is also reported. Eighty-seven patients underwent revision hip arthroscopy during the study period. Seventy (80.5%) patients were included in our study. Average follow-up time was 28 months (range, 20 to 47.4 months). In terms of residual femoroacetabular impingement morphology, 45.7% of patients had preoperative alpha angles ≥ 55°, and 7.14% of patients had a lateral center-edge angle ≥ 40°. The score improvement from preoperative to 2-year follow-up was 57.84 to 73.65 for mHHS, 62.79 to 83.04 for HOS-ADL, 37.33 to 54.93 for HOS-SSS, and 55.65 to 70.79 for NAHS. VAS decreased from 6.72 to 4.08. All scores demonstrated statistically significant improvement (P arthroscopy during the study period. We found an overall minor complication rate of 10%. Revision hip arthroscopy for all procedures performed on aggregate has improved clinical outcomes for all PROs, high survivorship, and high patient satisfaction scores at short-term follow-up. Patients should be counseled regarding the potential progression of degenerative change leading to arthroplasty and the potential for revision surgery. Level IV retrospective case series. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc

  2. Evaluation of Apoptosis and Autophagy Inducing Potential of Berberis aristata, Azadirachta indica, and Their Synergistic Combinations in Parental and Resistant Human Osteosarcoma Cells

    Science.gov (United States)

    Sengupta, Pracheta; Raman, Sukanya; Chowdhury, Rajdeep; Lohitesh, K.; Saini, Heena; Mukherjee, Sudeshna; Paul, Atish

    2017-01-01

    Cancer is a multifactorial disease and hence can be effectively overcome by a multi-constituently therapeutic strategy. Medicinal plant extracts represent a perfect example of such stratagem. However, minimal studies have been done till date that portray the effect of extraction techniques on the phyto-constituent profile of plant extracts and its impact on anticancer activity. In the present study, we have evaluated the anticancer potential of methanolic extracts of Berberis aristata root and Azadirachta indica seeds prepared by various extraction techniques in human osteosarcoma (HOS) cells. Soxhlation extract of B. aristata (BAM-SX) and sonication extract of A. indica (AIM-SO) were most effective in inducing apoptosis in parental drug sensitive, as well as resistant cell type developed by repeated drug exposure. Generation of reactive oxygen species and cell cycle arrest preceded caspase-mediated apoptosis in HOS cells. Interestingly, inhibition of autophagy enhanced cell death suggesting the cytoprotective role of autophagy. Combination studies of different methanolic extracts of BAM and AIM were performed, among which, the combination of BAM-SO and AIM-SO (BAAISO) was found to show synergism (IC50 10.27 µg/ml) followed by combination of BAM-MC and AIM-MC (BAAIMC) with respect to other combinations in the ratio of 1:1. BAAISO also showed synergism when it was added to cisplatin-resistant HOS cells (HCR). Chromatographic profiling of BAM-SX and AIM-SO by high performance thin layer chromatography resulted in identification of berberine (Rf 0.55), palmitine (Rf 0.50) in BAM-SX and azadirachtin A (Rf 0.36), azadirachtin B (Rf 0.56), nimbin (Rf 0.80), and nimbolide (Rf 0.43) in AIM-SO. The cytotoxic sensitivity obtained can be attributed to the above compounds. Our results highlight the importance of extraction technique and subsequent mechanism of action of multi-constituential B. aristata and A. indica against both sensitive and drug refractory HOS cells. PMID

  3. Evaluation of Apoptosis and Autophagy Inducing Potential of Berberis aristata, Azadirachta indica, and Their Synergistic Combinations in Parental and Resistant Human Osteosarcoma Cells

    Directory of Open Access Journals (Sweden)

    Pracheta Sengupta

    2017-12-01

    Full Text Available Cancer is a multifactorial disease and hence can be effectively overcome by a multi-constituently therapeutic strategy. Medicinal plant extracts represent a perfect example of such stratagem. However, minimal studies have been done till date that portray the effect of extraction techniques on the phyto-constituent profile of plant extracts and its impact on anticancer activity. In the present study, we have evaluated the anticancer potential of methanolic extracts of Berberis aristata root and Azadirachta indica seeds prepared by various extraction techniques in human osteosarcoma (HOS cells. Soxhlation extract of B. aristata (BAM-SX and sonication extract of A. indica (AIM-SO were most effective in inducing apoptosis in parental drug sensitive, as well as resistant cell type developed by repeated drug exposure. Generation of reactive oxygen species and cell cycle arrest preceded caspase-mediated apoptosis in HOS cells. Interestingly, inhibition of autophagy enhanced cell death suggesting the cytoprotective role of autophagy. Combination studies of different methanolic extracts of BAM and AIM were performed, among which, the combination of BAM-SO and AIM-SO (BAAISO was found to show synergism (IC50 10.27 µg/ml followed by combination of BAM-MC and AIM-MC (BAAIMC with respect to other combinations in the ratio of 1:1. BAAISO also showed synergism when it was added to cisplatin-resistant HOS cells (HCR. Chromatographic profiling of BAM-SX and AIM-SO by high performance thin layer chromatography resulted in identification of berberine (Rf 0.55, palmitine (Rf 0.50 in BAM-SX and azadirachtin A (Rf 0.36, azadirachtin B (Rf 0.56, nimbin (Rf 0.80, and nimbolide (Rf 0.43 in AIM-SO. The cytotoxic sensitivity obtained can be attributed to the above compounds. Our results highlight the importance of extraction technique and subsequent mechanism of action of multi-constituential B. aristata and A. indica against both sensitive and drug refractory HOS

  4. Business information literacy: informasjonskompetanse ved Handelshøyskolen BI

    Directory of Open Access Journals (Sweden)

    Sigrid Gimse

    2010-07-01

    Full Text Available For å bli en informasjonskompetent student innenfor en internasjonal akademisk handelshøgskole, er det spesielle ferdigheter man må opparbeide seg. Det er ikke de samme kravene til hva en må kunne ved Odontologisk fakultet som ved BI, så heller ikke i bibliotekets sfære. De ferdighetene vi er på jakt etter å utvikle hos våre studenter er generiske for handelshøyskoler verden over, men allikevel er begrepet ”Business Information Literacy” et ganske nytt begrep, og som så mye annet hentet fra USA. Vi synes det er et spennende begrep, all den tid det definerer hva som er kravene, utover den enkelte handelshøyskoles sfære. Vi tror at det kommer til å etableres en standard for denne kompetansen i USA snart, men før dette er klart har vi sett på hva begrepet betyr for oss. Det har nemlig ledet oss mot en særegen undervisnings- og bibliotekpedagogikk. Tilføyelsen ”Business” til begrepet informasjonskompetanse kommer selvsagt på toppen av den generelle definisjonen, som vi også ”bekjenner” oss til og prøver å utvikle hos våre studenter og faglige. Begrepet springer ut av BIs fagområder der kravene til ”Business Information Literacy” kan innebære: • Kunne innhente emnespesifikk fag- og forskningslitteratur i relevante bibliografiske kilder • Kunne innhente makroøkonomiske data nasjonalt og internasjonalt • Kunne innhente forbrukerdemografiske data • Kunne innhente data typiske for markedsanalyse • Kunne innhente data innen bedrifts- industri- og bransjeanalyse • Kunne innhente finansielle data • Kunne bruke juridiske kilder • Kunne inkorporere funn i egne oppgaver etter akademisk standard Hva gjør vi for å utvikle disse ferdighetene hos våre studenter? Hvilke tiltak setter vi verk? Hva gjør handelshøyskoler verden over? Mange bibliotek utvikler i dag elæringsmateriale for å kunne nå det store antall studenter. Dette er også underveis hos oss.

  5. Von Fouqué über Oehlenschläger bis Andersen

    DEFF Research Database (Denmark)

    de Mylius, Johan

    2010-01-01

    Centralromantisk myte i dens udformning hos Friedrich de la Motte Fouqué (1811), i Oehlenschlägers forkortede bearbejdelse og oversættelse (Eventyr af forskjellige Digtere, 1816) og HCAs "Den lille Havfrue" (1837)....

  6. Health Outcomes Survey - Limited Data Set

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medicare Health Outcomes Survey (HOS) limited data sets (LDS) are comprised of the entire national sample for a given 2-year cohort (including both respondents...

  7. Characterization of tissue plasminogen activator binding proteins isolated from endothelial cells and other cell types

    International Nuclear Information System (INIS)

    Beebe, D.P.; Wood, L.L.; Moos, M.

    1990-01-01

    Human tissue plasminogen activator (t-PA) was shown to bind specifically to human osteosarcoma cells (HOS), and human epidermoid carcinoma cells (A-431 cells). Crosslinking studies with DTSSP demonstrated high molecular weight complexes (130,000) between 125 I-t-PA and cell membrane protein on human umbilical vein endothelial cells (HUVEC), HOS, and A-431 cells. A 48-65,000 molecular weight complex was demonstrated after crosslinking t-PA peptide (res. 7-20) to cells. Ligand blotting of cell lysates which had been passed over a t-PA affinity column revealed binding of t-PA to 54,000 and 95,000 molecular weight proteins. Several t-PA binding proteins were identified in immunopurified cell lysates, including tubulin beta chain, plasminogen activator inhibitor type 1 and single chain urokinase

  8. A unique TBX5 microdeletion with microinsertion detected in patient with Holt-Oram syndrome.

    Science.gov (United States)

    Morine, Mikio; Kohmoto, Tomohiro; Masuda, Kiyoshi; Inagaki, Hidehito; Watanabe, Miki; Naruto, Takuya; Kurahashi, Hiroki; Maeda, Kazuhisa; Imoto, Issei

    2015-12-01

    Holt-Oram syndrome (HOS) is an autosomal dominant condition characterized by upper limb and congenital heart defects and caused by numerous germline mutations of TBX5 producing preterminal stop codons. Here, we report on a novel and unusual heterozygous TBX5 microdeletion with microinsertion (microindel) mutation (c.627delinsGTGACTCAGGAAACGCTTTCCTGA), which is predicted to synthesize a truncated TBX5 protein, detected in a sporadic patient with clinical features of HOS prenatally diagnosed by ultrasonography. This uncommon and relatively large inserted sequence contains sequences derived from nearby but not adjacent templates on both sense and antisense strands, suggesting two possible models, which require no repeat sequences, causing this complex microindel through the bypass of large DNA adducts via an error-prone DNA polymerase-mediated translesion synthesis. © 2015 Wiley Periodicals, Inc.

  9. Increased utilisation of primary healthcare in persons exposed to severe stress in prenatal life

    DEFF Research Database (Denmark)

    Li, Jiong; Yang, Hu; Guldin, Mai-Britt

    2015-01-01

    Meget tyder på, at stress i graviditeten kan skade det ufødte barn. Dette studie viser, at sorg hos moderen under graviditeten kan betyde, at barnet senere i livet søger læge mere hyppigt sammenlignet med børn, hvor moderen ikke har været i sorg under graviditeten. Det er især, hvis moderen under...... menneskes liv, og at det kan påvirke det ufødte barn, når moderen bliver stresset under graviditeten. Vi ved dog ikke helt, om den øgede lægesøgning hos børnene kun skyldes stress i graviditeten, eller om de også påvirkes af, om moderen fx har mistet sin ægtefælle, og den betydning det kan have for barnets...

  10. Parasit er forklædt som vært

    DEFF Research Database (Denmark)

    Buchmann, Kurt

    2008-01-01

    Parasitter kan koble værtens egne molekyler til overfladen hvorved værtens eget immunforsvar ikke kan genkende snylteren. Det er bl.a. vist hos voksmøllet og dets nematodparasit Udgivelsesdato: 6. juni...

  11. 3D facial expression recognition based on histograms of surface differential quantities

    KAUST Repository

    Li, Huibin; Morvan, Jean-Marie; Chen, Liming

    2011-01-01

    . To characterize shape information of the local neighborhood of facial landmarks, we calculate the weighted statistical distributions of surface differential quantities, including histogram of mesh gradient (HoG) and histogram of shape index (HoS). Normal cycle

  12. Higher-Order Statistics for the Detection of Small Objects in a Noisy Background Application on Sonar Imaging

    Directory of Open Access Journals (Sweden)

    M. Amate

    2007-01-01

    Full Text Available An original algorithm for the detection of small objects in a noisy background is proposed. Its application to underwater objects detection by sonar imaging is addressed. This new method is based on the use of higher-order statistics (HOS that are locally estimated on the images. The proposed algorithm is divided into two steps. In a first step, HOS (skewness and kurtosis are estimated locally using a square sliding computation window. Small deterministic objects have different statistical properties from the background they are thus highlighted. The influence of the signal-to-noise ratio (SNR on the results is studied in the case of Gaussian noise. Mathematical expressions of the estimators and of the expected performances are derived and are experimentally confirmed. In a second step, the results are focused by a matched filter using a theoretical model. This enables the precise localization of the regions of interest. The proposed method generalizes to other statistical distributions and we derive the theoretical expressions of the HOS estimators in the case of a Weibull distribution (both when only noise is present or when a small deterministic object is present within the filtering window. This enables the application of the proposed technique to the processing of synthetic aperture sonar data containing underwater mines whose echoes have to be detected and located. Results on real data sets are presented and quantitatively evaluated using receiver operating characteristic (ROC curves.

  13. Hip Arthroscopy for Femoral-Acetabular Impingement: Do Active Claims Affect Outcomes?

    Science.gov (United States)

    Gigi, Roy; Rath, Ehud; Sharfman, Zachary T; Shimonovich, Shachar; Ronen, Itai; Amar, Eyal

    2016-04-01

    To compare outcomes of 3 patient groups undergoing hip arthroscopy. This study included 138 consecutive hip arthroscopies (106 analyzed) for femoral-acetabular impingement (FAI) with or without labral tear in patients with a minimum 1-year follow-up. Inclusion criteria included patients older than 18 with clinical or radiologic manifestation of FAI with or without labral tear. Exclusion criteria included previous hip surgery and various hip pathologies. Patients were classified into 3 study groups. Group 1 included work-related injuries with active claims ACs (n = 33); mean age, 32 (range, 19 to 63); group 2 included sports injuries with no ACs (n = 35); mean age, 32 (range, 18 to 69); and group 3 included non-sports-related injuries without pending ACs (NAS; n = 38); mean age, 45 (range, 20 to 68). Outcomes were assessed using modified Harris hip scores (mHHS) and hip outcome scores (HOS) preoperatively and during the final evaluation. Baseline score for all groups did not significantly differ (P = .210 for mHHS, P = .176 for HOS). All groups significantly improved from preoperative to final evaluation (group 1: mHHS P = .42, HOS P = .001; group 2: mHHS P arthroscopy. Hip arthroscopy as an intervention in patients with ACs provided positive outcomes, corroborating that an AC is not a contraindication for this procedure. Level III, retrospective comparative study. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  14. Enhanced biological properties of biomimetic apatite fabricated polycaprolactone/chitosan nanofibrous bio-composite for tendon and ligament regeneration.

    Science.gov (United States)

    Wu, Geng; Deng, Xuefeng; Song, Jinqi; Chen, Feiqiang

    2018-01-01

    The development of tailored nanofibrous scaffolds for tendon and ligament tissue engineering has been a goal of clinical research for current researchers. Here, we establish a formation of novel nanofibrous matrix with significant mechanical and biological properties by electro-spinning process. The fine fibrous morphology of the nanostructured hydroxyapatite (HAp) dispersed in the polycaprolactone/chitosan (HAp-PCL/CS) nanofibrous matrix was exhibited by microscopic (SEM and TEM) techniques. The favorable mechanical properties (load and modulus) were achieved. The load and modulus of the HAp-PCL/CS composite fibers was 250.1N and 215.5MPa, which is very similar to that of standard value of the human tendon and ligament tissues. The cellular responses and biocompatibility of HAp-PCL/CS nanofibrous scaffolds were investigated with human osteoblast (HOS) cells for tendon regeneration and examined the primary osteoblast mechanism by in vitro method. The morphological (FE-SEM and fluorescence) microscopic images clearly exhibited that HOS cells are well attached and flatted on the nanofibrous composites. The HAp dispersed PCL/CS nanofibrous scaffolds promoted higher adhesion and proliferation of HOS cells comparable to the nanofibrous scaffolds without HAp nanoparticles. The physic-chemical and biological properties of the synthesized nanofibrous scaffold were very close to that of normal ligament and tendon in human body. Over all, these studied results confirmed that the prepared nanofibrous scaffolds will be effective biomaterial of tendon ligament regeneration applications. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. The influence of differential processing of procathepsin H on its aminopeptidase activity, secretion and subcellular localization in human cell lines.

    Science.gov (United States)

    Rojnik, Matija; Jevnikar, Zala R; Doljak, Bojan; Turk, Samo; Zidar, Nace; Kos, Janko

    2012-10-01

    Cathepsin H is a unique member of the cysteine cathepsins that acts primarily as an aminopeptidase. Like other cysteine cathepsins, it is synthesized as an inactive precursor and activated by proteolytic removal of its propeptide. Here we demonstrate that, in human cells, the processing of the propeptide is an autocatalytic, multistep process proceeding from an inactive 41kDa pro-form, through a 30kDa intermediate form, to the 28kDa mature form. Tyr87P and Gly90P were identified as the two major endopeptidase cleavage sites, converting the 30kDa form into the mature 28kDa form. The level of processing differs significantly in different human cell lines. In monocyte-derived macrophages U937 and prostate cancer cells PC-3, the 28kDa form is predominant, whereas in osteoblasts HOS the processing from the 30kDa form to the 28kDa form is significantly lower. The aminopeptidase activity of the enzyme and its subcellular localization are independent of the product, however the 30kDa form was not secreted in HOS cells. The activity of the resulting cathepsin H in U937 cells was significantly lower than that in HOS cells, presumably due to the high levels of endogenous cysteine protease inhibitor cystatin F present specifically in this cell line. These results provide an insight into the dependence of human cathepsin H processing and regulation on cell type. Copyright © 2012 Elsevier GmbH. All rights reserved.

  16. Vi kan ikke afskaffe det ubærlige ved lov

    DEFF Research Database (Denmark)

    Post, Bettina

    2012-01-01

    Man bliver ikke rask af beskæftigelsesindsats. Heller ikke når man har en psykisk sygdom. Alligevel er det langt hen ad vejen forestillingen hos de politikere, som beslutter reglerne omkring fleksjob og førtidspension....

  17. Attitudes of truck drivers and carriers on the use of electronic logging devices and driver harassment.

    Science.gov (United States)

    2014-11-01

    The research contained herein is an examination of managerial harassment experienced by drivers, and whether harassment is associated with the method used to log hours of service (HOS). Similar information was gathered from a sample of carriers. : Tr...

  18. Bevægende arkitektur

    DEFF Research Database (Denmark)

    Kural, René

    2008-01-01

    Om Fuji børnehaven i Tachikawa, hvor arkitekturen er et levende bevis på, at den kan fremme fysisk aktivitet hos mindre børn. Institutionen bygger på pædagogik af den italienske professor Marie Montesori....

  19. Association between Risk Factors and Overnight Albumin/Creatinine Ratio - even in its Normal Range

    DEFF Research Database (Denmark)

    Olivarius, Niels de Fine; Andreasen, A.H.; Mogensen, C.E.

    1994-01-01

    I denne lille artikel påvises det, at selv en ganske let forøget udskillelse af albumin i urinen forekommer hyppigere hos aldersdiabetikere med (andre) risikofaktorer såsom hypertension, hyperlipidæmi, hyperglykæmi etc. Udgivelsesdato: 1994...

  20. Exploring super-gaussianity towards robust information-theoretical time delay estimation

    DEFF Research Database (Denmark)

    Petsatodis, Theodoros; Talantzis, Fotios; Boukis, Christos

    2013-01-01

    the effect upon TDE when modeling the source signal with different speech-based distributions. An information theoretical TDE method indirectly encapsulating higher order statistics (HOS) formed the basis of this work. The underlying assumption of Gaussian distributed source has been replaced...

  1. First report of Pandora neoaphidis resting spore formation in vivo in aphid hosts under field conditions

    Science.gov (United States)

    The entomopathogenic fungus PANDORA NEOAPHIDIS is a recognized pathogen of aphids, causing natural epizootics in aphid populations, and interacts favorably with aphid predators and parasitoids. Survival of entomophthoralean fungi in periods of unsuitable weather conditions or lack of appropriate hos...

  2. Sundhedspleje fremmer integration

    DEFF Research Database (Denmark)

    Hansen, Lisbet Vestergaard; Hedegaard, Rie

    2002-01-01

    Etniske minoritetsfamilier har ofte en helt anden opfattelse af børns kompetencer og behov end danske familier. Det kan gøre det svært for sundhedsplejersken at opnå forståelse for sine synspunkter hos familierne...

  3. Bæredygtighed hos SMV'er

    DEFF Research Database (Denmark)

    2016-01-01

    Valg af materiale/medie/form: YouTube Valg af arbejdsform: Videoerne kan bruges som caseundervisning Begrundelse for valg af materiale/medie/form/arbejdsform: Caseundervisning er velegnet til at lære om praksis......Valg af materiale/medie/form: YouTube Valg af arbejdsform: Videoerne kan bruges som caseundervisning Begrundelse for valg af materiale/medie/form/arbejdsform: Caseundervisning er velegnet til at lære om praksis...

  4. Delirium hos kritisk syge patienter

    DEFF Research Database (Denmark)

    Strøm, Thomas; Pande-Rolfsen, Guri; Hagen, Christine

    2009-01-01

    Interest in and the quantity of publications on delirium in critically ill patients have grown increasingly over the last decade. Critically ill patients have traditionally been sedated to facilitate mechanical ventilation. This practice impeded the recognition of delirium in the critically ill p...

  5. Konstruktionsforberedelse hos Kværner

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Radmer, Jim

    1997-01-01

    Konstruktionsforberedelse kan parallelt til produktionsforberedelse opfattes som opbygning af beredskab og "iscenesættelse" før det egentlige konstruktionsarbejde gennemføres. Der eksisterer allerede i praksis mange måder til opnåelse af større konstruktionsforberedelsesgrad. Toyota anvender...

  6. Kognitiv profil hos eldre ledere

    OpenAIRE

    Holth, Torill

    2006-01-01

    Når lederen beveger seg inn i senyrkesfasen ser det ut til at svært mange velger å tre ut av lederstillingen sin. Dette har både personlige og organisasjonsmessige konsekvenser. En liten gruppe ledere over 55 år er studert med hensyn til deres kognitive profil som består av kognitiv kompleksitet, feltuavhengighet, visdom og læringshistorie. De eldste lederne hadde flere av disse egenskapene. Ett felles trekk for samtlige deltakere viste seg å være deres subjektive mestringsforventning. ...

  7. Botulisme hos spaedbørn

    DEFF Research Database (Denmark)

    Hoffmann, Thomas; Mølbak, Kåre; Paerregaard, Anders

    2010-01-01

    of voluntary muscles. Presenting symptoms include constipation, lethargy, mydriasis and ptosis. The diagnosis is made on the basis of clinical examination and confirmed by isolating the toxin in serum or stools. Treatment consists of supportive intensive care and treatment with antitoxins....

  8. Botulisme hos spaedbørn

    DEFF Research Database (Denmark)

    Hoffmann, Thomas; Mølbak, Kåre; Paerregaard, Anders

    2010-01-01

    Infant botulism is a rare disease that affects infants below the age of 12 months following absorption of neurotoxins produced by ingested Clostridium botulinum spores. The clinical manifestations are caused by symmetrical cranial nerve palsies followed by descending, symmetric flaccid paralysis...

  9. Demenslidelser hos aeldre tyrkiske indvandrere

    DEFF Research Database (Denmark)

    Rosenbaum, Bent; Kristensen, Majken; Schmidt, John

    2008-01-01

    The health condition in a population of elderly Turkish immigrants is investigated with special focus on dementia conditions. The possibility to use the screening test Mini Mental State Examination (MMSE) in relation to the investigated population is evaluated as well as their future need...

  10. Diagrammer hos Pierce og Deleuze

    DEFF Research Database (Denmark)

    Busk, Malene

    2006-01-01

    Artiklen omhandler to forskellige begreber om diagrammet, nemlig Pierces og Deleuzes. De definerer udfra to meget forskellige udgangspukter begge diagrammet som kreativt redskab......Artiklen omhandler to forskellige begreber om diagrammet, nemlig Pierces og Deleuzes. De definerer udfra to meget forskellige udgangspukter begge diagrammet som kreativt redskab...

  11. PTSD hos ældre efterladte

    DEFF Research Database (Denmark)

    O'Connor, Maja

    2009-01-01

    Intro: Tab af ægtefælle i alderdommen kan være en traumatisk begivenhed med reaktioner og symptomer på linje med dem, man nogle gange ser efter overfald, ulykker og naturkatastrofer. Det slår en ny undersøgelse fast. Udgivelsesdato: Maj 2009...

  12. Astma hos børn

    DEFF Research Database (Denmark)

    Bønnelykke, Klaus; Pedersen, Søren; Rubak, Sune Leisgaard Mørck

    2013-01-01

    These clinical guidelines were developed by the Danish Pediatric Asthma Center in collaboration with the Danish Paediatric Society. Key messages in the guidelines are: 1) Inhaled steroids are the most effective preventive medication and are first choice in children with persistent symptoms. 2) Th...

  13. Behandling af astma hos gravide

    DEFF Research Database (Denmark)

    Akram, Iram; Ulrik, Charlotte Suppli; Johnsen, Claus Rikard

    2016-01-01

    Asthma is one of the most frequent chronic diseases which complicate pregnancy. Well-controlled asthma during pregnancy reduces the risk of for exacerbations and, consequently, the risk of adverse pregnancy outcome. Pharmacological therapy for pregnant women with asthma is a challenge, not least ...

  14. Ulnarisneuropati hos fjerkræslagteriarbejder

    DEFF Research Database (Denmark)

    Svendsen, Susanne Wulff; Juhl, Anne

    2008-01-01

    Three months after he was employed as a poultry worker, a 48-year-old man developed involuntary jerks of his right first, fourth, and fifth fingers, paraesthesiae, weakness, and eventually wasting of the first dorsal interosseous muscle. His job entailed repetitive lifting of boxes weighing 10-25...

  15. Hopi Indian Witchcraft and Healing

    DEFF Research Database (Denmark)

    Geertz, Armin W.

    2011-01-01

    Artiklen undersøger hekseri, sygdom og helbredelse hos hopi-indianerne dels på baggrund af egne indsamlede interviews og af litteraturen. Hekseri anskues delvis som narrativ strategi således at sladder fungerer som en omvendt etisk redskab. Desuden inddrages kognitive teorier....

  16. Neuromuscular function in patients with Subacromial Impingement Syndrome and clinical assessment of scapular kinematics

    DEFF Research Database (Denmark)

    Larsen, Camilla Marie

    muskeldele.I det andet studie blev evnen til selektiv aktivering af de individuelle skapulære muskeldele undersøgt hos 15patienter med SIS under en session med og uden visuel biofeedback, sammenlignet med denne evne hos 15raske kontroller. Med udgangspunkt i præ-definerede kriterier for selektiv aktivering...... kontrolpersonerne opnåede selektiv aktiveringaf individuelle skapulære muskeldele, når de ikke modtog visuel biofeedback af muskelaktiviteten af deenkelte muskeldele.I det tredje studie blev der udarbejdet et systematisk review af alle tilgængelige kliniske målemetoder tilvurdering af skapulas position og bevægelse...... den neuromuskulære aktivitet blandt SIS patienter ograske kontrolpersoner ikke fundet. Derimod viste undersøgelsen af den neuromuskulære funktion med og udenbrug af visuel biofeedback, at uden brug af biofeedback havde kontrolgruppen en bedre kontrol af deskapulære muskler. Dog præsterede SIS...

  17. Opposite Effects of Soluble Factors Secreted by Adipose Tissue on Proliferating and Quiescent Osteosarcoma Cells.

    Science.gov (United States)

    Avril, Pierre; Duteille, Franck; Ridel, Perrine; Heymann, Marie-Françoise; De Pinieux, Gonzague; Rédini, Françoise; Blanchard, Frédéric; Heymann, Dominique; Trichet, Valérie; Perrot, Pierre

    2016-03-01

    Autologous adipose tissue transfer may be performed for aesthetic needs following resection of osteosarcoma, the most frequent primary malignant tumor of bone, excluding myeloma. The safety of autologous adipose tissue transfer regarding the potential risk of cancer recurrence must be addressed. Adipose tissue injection was tested in a human osteosarcoma preclinical model induced by MNNG-HOS cells. Culture media without growth factors from fetal bovine serum were conditioned with adipose tissue samples and added to two osteosarcoma cell lines (MNNG-HOS and MG-63) that were cultured in monolayer or maintained in nonadherent spheres, favoring a proliferation or quiescent stage, respectively. Proliferation and cell cycle were analyzed. Adipose tissue injection increased local growth of osteosarcoma in mice but was not associated with aggravation of lung metastasis or osteolysis. Adipose tissue-derived soluble factors increased the in vitro proliferation of osteosarcoma cells up to 180 percent. Interleukin-6 and leptin were measured in higher concentrations in adipose tissue-conditioned medium than in osteosarcoma cell-conditioned medium, but the authors' results indicated that they were not implicated alone. Furthermore, adipose tissue-derived soluble factors did not favor a G0-to-G1 phase transition of MNNG-HOS cells in nonadherent oncospheres. This study indicates that adipose tissue-soluble factors activate osteosarcoma cell cycle from G1 to mitosis phases, but do not promote the transition from quiescent G0 to G1 phases. Autologous adipose tissue transfer may not be involved in the activation of dormant tumor cells or cancer stem cells.

  18. History and Nature of Science enriched Problem-Based Learning on the origins of biodiversity and of continents and oceans

    Directory of Open Access Journals (Sweden)

    Cristina Sousa

    2014-09-01

    Full Text Available The episode of the History of Science (HOS on the theory of continental drift proposed by Alfred Wegener has been considered an excellent example for teaching students aspects of Nature of Science (NOS and the relation of Science with social and tecnological contexts. We implemented a NOS and HOS-enriched Problem-Based Learning environment at the middle (year 7 of the Portuguese National Curriculum and secondary level (year 10 for teaching the origins of biodiversity and of continents and oceans (mobilism.  The goal of providing detailed implementation practices is to adress the lack of how to in Problem-based learning (PBL implementation in classrooms for 12 to 16 year old students and is the first practical example of implementation using this episode of HOS for teaching geological mobilism integrated with evolution. Therefore, in this study, we provide specific suggestions for supporting teachers’ classroom efforts in implementing PBL, such as scaffolding. The ill-problem presented to students, without a single correct answer, was based on the phylogeny of extant and extinct ratite birds, described by Charles Darwin and the present geographical distribution. The evaluation of the students was focused on the chain of reasoning employed, and we performed a comparisation analysis of the problem’s solution presented by the students of both classes regarding the explanation of the phylogeny of ratites based on geological mobilism. We observed an overall improvement (25-77% of the percentages of students pre- and post-instruction adequate answers; therefore our PBL strategy was efficient.

  19. Biological performance of titania containing phosphate-based glasses for bone tissue engineering applications

    International Nuclear Information System (INIS)

    Abou Neel, Ensanya Ali; Chrzanowski, Wojciech; Knowles, Jonathan Campbell

    2014-01-01

    The interplay between glass chemistry, structure, degradation kinetics, and biological activity provides flexibility for the development of scaffolds with highly specific cellular response. The aim of this study was therefore to investigate the role of titania inclusion into the phosphate-based glass on its ability to stimulate osteoblast-like human osteosarcoma (HOS) cells to adhere, proliferate and differentiate. In depth morphological and biochemical characterisation was performed on HOS cells cultured on the surface of glass discs. Cell proliferation was also studied in the presence of the glass extract. Cell differentiation, through osteoblast phenotype genes, alkaline phosphatase (ALP) activity and osteocalcin production, was carried out using normal or osteogenic media. Both Thermanox® and titania free glass were used as controls. The data demonstrated that titania inclusion provides desired cytocompatible surface that supported initial cell attachment, sustained viability, and increased cell proliferation similar or significantly higher than Thermanox®. The modified glasses regulated osteoblastic cell differentiation as detected by osteoblast phenotype gene transcription and upregulated ALP and osteocalcin expression. Using osteogenic media had no significant effect on ALP activity and osteocalcin expression. Therefore, titania modified phosphate glasses may have future use as bone tissue engineering scaffolds. - Highlights: • This study investigated the role of titania on the biological response of phosphate glasses. • Incorporation of titania improved HOS cell attachment, viability and proliferation. • Titania modified glasses regulated osteoblastic cell differentiation. • Using osteogenic media had no significant effect on cell differentiation. • Titania modified glasses may have future use as bone tissue engineering scaffolds

  20. Application of OMICS technologies in occupational and environmental health research; current status and projections.

    NARCIS (Netherlands)

    Vlaanderen, J.J.; Moore, L.E.; Smith, M.T.; Lan, Q.; Zhang, L.; Skibola, C.F.; Rothman, N.; Vermeulen, R.

    2010-01-01

    OMICS technologies are relatively new biomarker discovery tools that can be applied to study large sets of biological molecules. Their application in human observational studies (HOS) has become feasible in recent years due to a spectacular increase in the sensitivity, resolution and throughput of

  1. 77 FR 25181 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2012-04-27

    ... outcomes measures, the HOS is used to collect the Management of Urinary Incontinence in Older Adults, Physical Activity in Older Adults, Fall Risk Management, and Osteoporosis Testing in Older Women HEDIS... collections please reference the document identifier or OMB control number. To be assured consideration...

  2. 75 FR 31790 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2010-06-04

    ... the Management of Urinary Incontinence in Older Adults, Physical Activity in Older Adults, Fall Risk Management, and Osteoporosis Testing in Older Women HEDIS[supreg] measures. The collection of Medicare HOS is... document identifier or OMB control number. To be assured consideration, comments and recommendations must...

  3. Bulldog-paradokset

    DEFF Research Database (Denmark)

    Sandøe, Peter

    2017-01-01

    Hidtil har det været en udbredt opfattelse, at problemer med usunde racehunde alene skyldes kyniske avlere. Resultater fra en dansk undersøgelse peger dog på, at ansvaret for problemet også ligger hos dem, der efterspørger de usunde recahunde....

  4. Epilepsi og orale manifestationer

    DEFF Research Database (Denmark)

    Jacobsen, Pernille Endrup; Haubek, Dorte; Østergaard, John Rosendahl

    2016-01-01

    Risiko for sygdom I mundhulen hos patienter med epilepsy Epilepsi er en kronisk neurologisk lidelse, der ofte vil kræve medicinsk behandling for at holde patienterne fri for anfald. Lidelsen kan have betydning for patientens psykosociale og kognitive udvikling, der indirekte kan have betydning...

  5. Context as a drug

    DEFF Research Database (Denmark)

    Lucassen, P; Olesen, F

    2016-01-01

    Denne oversigtsartikel viser, at hele konteksten omkring konsultationen hos lægen har en stærk indvirkning på patientens opfattelse af symptomer. På baggrund af forskning i placebo-nocebo inden for smertebehandling i den vestlige verden diskuterer forfatterne af artiklen, hvordan forskellige elem...

  6. Den skrøbelige sandhed

    DEFF Research Database (Denmark)

    Pedersen, Peter Ole

    2010-01-01

    Artiklen retter fokus mod de seneste års udvikling af den aktivistiske dokumentarfilm. Med analytiske punktnedslag hos instruktørerne Michael Moore, Morgan Spurlock, Dylan Avery, Robert Greenwald og Mauro Andrizzi undersøges de forbindelser der eksisterer mellem udtrykket i de populære spillefilm...

  7. 78 FR 64265 - Hours of Service of Drivers: U.S. Department of Defense (DOD); Application for Exemption

    Science.gov (United States)

    2013-10-28

    ... break provision of the Agency's hours-of-service (HOS) regulations for commercial motor vehicle (CMV... requirements in Sec. 395.3(a)(3)(ii). SDDC states that it requires continuous attendance and surveillance of... surveillance. Inspecting carrier facilities and corporate headquarters for compliance with DOD and DOT...

  8. Seminational surveillance of fungemia in Denmark: Notably high rates of fungemia and numbers of isolates with reduced azole susceptibility

    DEFF Research Database (Denmark)

    Arendrup, M.C.; Fuursted, K.; Gahrn-Hansen, B.

    2005-01-01

    The aim of this study was to present the first set of comprehensive data on fungemia in Denmark including the distribution of species and range of susceptibility to major antifungal compounds based on a seminational surveillance study initiated in 2003. The catchment area of the participating hos...

  9. Brugerinvolvering i design af læreprocesser – refleksioner over et større forsknings- og udviklingsprojekt

    DEFF Research Database (Denmark)

    Helms, Niels Henrik; Heilesen, Simon

    2012-01-01

    quadruple helix model. Begrebet "didaktisk design" problematiseres ud fra betragtningen, at der i design-aktiviteter er behov for at medtænke og involvere forskellige tilgange samt forskellige kompetencer hos aktørerne. "Design thinking" inddrages for at pointere, at design er en eksplorativ, dialogisk og...

  10. Brugerinvolvering i design af læreprocesser

    DEFF Research Database (Denmark)

    Heilesen, Simon; Helms, Niels Henrik

    2012-01-01

    quadruple helix model. Begrebet "didaktisk design" problematiseres ud fra betragtningen, at der i design-aktiviteter er behov for at medtænke og involvere forskellige tilgange samt forskellige kompetencer hos aktørerne. "Design thinking" inddrages for at pointere, at design er en eksplorativ, dialogisk og...

  11. Brugerdreven innovation

    DEFF Research Database (Denmark)

    Dinesen, Birthe; Huniche, Lotte; Madsen, Jacob

    Formålet med denne publikation er at beskrive kreative teknikker til, hvordan du kan spotte nye behov for brug af velfærdsteknologi hos mennesker med kroniske lidelser til at mestre egen sygdom. I forsknings- og innovationsprojektet TELEKAT – Telehomecare, kroniske patienter og det samarbejdende ...

  12. Når troen bliver til sang

    DEFF Research Database (Denmark)

    Nielsen, Kirsten

    2009-01-01

    I anmeldelsen fremhæver jeg, at Selander i denne artikelsamling både beskæftiger sig med salmeteksterne og med melodierne. Denne dobbeltkompetence er usædvanlig hos en litteraturforsker. Artiklerne giver et fint indblik i svensk salmetradition samt i komponisternes arbejde med melodierne. Selande...

  13. An Analysis of the Model and Enacted Curricula for a History of Science Course in a Nationwide Teacher Education Program

    Science.gov (United States)

    Nouri, Noushin

    2017-01-01

    The UTeach program, a national model for undergraduate teacher preparation, includes "Perspectives on Science and Mathematics," a class designed to share content about the History of Science (HOS) with preservice teachers. UTeach provides a model curriculum as a sample for instructors teaching "Perspectives." The purpose of…

  14. Djævelen som Guds advokat - Nietzsche, filosofien og Paulus

    DEFF Research Database (Denmark)

    Pallesen, Carsten

    2012-01-01

    Artiklen tegner et dobbeltportræt af Paulus og Nietzsche ud fra en række nyere diskussioner om Nietzsches syn på Paulus hos aktuelle Nietzscheforskere, men også med udblik til den Paulus-renæssance, som har fundet sted i filosofien. Med det sidste tænkes navnlig på den franske filosof Alain Badious...... tese om Paulus som universalismens tænker. Artiklen fremhæver, hvordan hermeneutiske, kommunikationsteoretiske og semiotiske tilgange i den nyere tyske forskning navnlig hos Werner Stegmaier har ændret synet på forholdet mellem Nietzsches ’tegn’ (Dionysos, Zarathustra, ’anti-krist’) over for Nietzsches...... retfærdiggørelse ved troen. Nietzsches forhold til kristendommen er ikke kun bestemt af negative vurderinger, men tillige af en ambivalent taknemmelighed, som når han i den sene fase af forfatterskabet på en gang identificerer sig med Dionysos og ’den korsfæstede’....

  15. Attendance of routine childcare visits in primary care for children of mothers with depression

    DEFF Research Database (Denmark)

    Lyngsøe, Bente Kjær; Vestergaard, Claus Høstrup; Rytter, Dorte

    2018-01-01

    Børn af mødre med depression kommer sjældnere til børneundersøgelser og bliver sjældnere vaccineret end mange andre børn. Dette studie viser, at risikoen for at udeblive fra mindst 50 pct. af alle forebyggende børneundersøgelser var 16 pct. højere for børn af mødre med depression sammenlignet med...... børn af mødre uden depression. Forskerne fandt, at depression hos moderen øger risikoen for, at barnet ikke deltager i børneundersøgelser og vaccinationer hos den praktiserende læge. Denne sammenhæng ses i flere år, selv når moderen ikke længere kategoriseres som deprimeret. Konsultationer ifm. børne...... kæmpet ─ med depression kræver særlig opmærksomhed, hvis velfærden skal nå alle....

  16. Associations between sedation, delirium and post-traumatic stress disorder and their impact on quality of life and memories following discharge from an intensive care unit

    DEFF Research Database (Denmark)

    Svenningsen, Helle

    2013-01-01

    . Sammenhængen mellem sedation, delirium og PTSD er ikke tidligere belyst. Formålet med dette ph.d.-studie var 1) at undersøge hvordan sedation påvirker udviklingen af delirium mens patienten er på intensivafdeling 2) at undersøge hvilken betydning delirium har for udviklingen af PTSD, angst og depression 2 og 6...... % havde PTSD; 6 % vs. 4 % havde angst og depression sås hos 10 %. Delirium havde ingen indflydelse på den efterfølgende psykometri. Erindringerne om vrangforestillinger og følelser hvad derimod statistisk signifikant betydning, modsat faktuelle erindringer. Livskvalitetsmålingerne viste kun differencer...... hos patienter med PTSD, angst og/eller depression, og var således ikke påvirket af evt. delirium eller hvilke erindringer patienterne havde fra intensivopholdet. Konklusionerne bliver således at fluktuationer i sederingsniveau øger forekomsten af delirium, men at det ikke direkte øger risikoen...

  17. Depressive Symptoms and Risk of New Cardiovascular Events or Death in Patients with Myocardial Infarction: A Population-Based Longitudinal Study Examining Health Behaviors and Health Care Interventions

    DEFF Research Database (Denmark)

    Larsen, Karen Kjær; Christensen, Bo; Søndergaard, Jens

    2013-01-01

    Mange mennesker rammes af depression efter en blodprop i hjertet (AMI), og denne kombination er forbundet med en dårligere prognose. Dette studie er det første, der viser, at depression udgør en selv-stændig risikofaktor for tidlig død hos patienter med blodprop i hjertet. Undersøgelsen tyder dog...... bruges til at skærpe opmærksomheden over for denne patientgruppe hos de praktiserende læger, hvor op mod 90 % af alle patienter med depression bliver diagnosticeret og behandlet. Background: Depressive symptoms is associated with adverse cardiovascular outcomes in patients with myocardial infarction (MI......), but the underlying mechanisms are unclear and it remains unknown whether subgroups of patients are at a particularly high relative risk of adverse outcomes. We examined the risk of new cardiovascular events and/or death in patients with depressive symptoms following first-time MI taking into account other secondary...

  18. Abstract: SMAG PÅ SKOLEMAD

    DEFF Research Database (Denmark)

    Mithril, Charlotte Elisabeth; Kamuk, Anette

    En sund kost er vigtig for at sikre optimal vækst, udvikling og sundhed hos børn og unge. Der er derfor stor fokus på strategier, der kan fremme sundere kostvaner hos børn og unge, og her er skolemaden blevet et centralt omdrejningspunkt. Men hvad skal der til for, at eleverne spiser (og elsker...... velsmagende skolemad. Vi fandt, at hvis skolemadsordninger skal tilbyde velsmagende og sunde måltider skal det samtidig være et velfungerende aktiv for skolerne, hvor eleverne inddrages og bruger deres smag bevidst. Det anbefales at: 1) skolens ledelse samtænker skolemadsordninger og pædagogiske aktiviteter......) den sunde skolemad? Her spiller smagen en vigtig rolle. Hovedformålet har været at belyse praksis knyttet til arbejdet med smag i skolemadsordninger. Målet er at bidrage til, hvordan denne praksis kan understøttes og udvikles, således at smag som ressource og motivationsfaktor kan blive en drivkraft...

  19. Ambivalente fiktioner

    DEFF Research Database (Denmark)

    Hansen, Kim Toft

    2010-01-01

    repræsentation af vold hos Henning Mankell med fokus på Innan frosten fra 2002 og filmatiseringen heraf fra 2005, men med et fyldigt udblik til Mankells novelle ”Sprickan”, og ikke mindst diskussioner af voldens forstyrrelse af demokrati og velfærdsstat hos Mankell. Således er Mankells krimifortællinger i dette...... tilfælde ligeså vel et springpunkt ind i mere sociologiske diskussioner af det kriminelle, volden og konstitutionen af et demokrati. Artiklen her er derfor såvel en analyse af som en tænkning med primært Mankells Innan frosten. I denne fortælling er det sociale fodfæste og overfladeidyllen nemlig...... kuldkastet af udemokratiske mekanismer i en fundamentalistisk religiøs trosretning. I overvejelsen af denne intrige vender jeg blikket mod ambivalensen inkluderet i både Mankells gennemgående efterforsker Wallander og de demokratiske strukturer, som Mankell diskuterer flere steder....

  20. Svangerskapskomplikasjoner og risikoen for astma blant nordmenn født 1967-1993

    Directory of Open Access Journals (Sweden)

    Per Nafstad

    2009-10-01

    Full Text Available Bakgrunn  Metode  Resultater  Konklusjon  Background  : Fetal life events may affect the development of the immune and/or respiratory system and increase the risk of asthma and allergic diseases. The objective of this study was to test the hypothesis that pregnancy complications are associated with the risk of developing asthma in the offspring.Methods  : The study population comprised Norwegian live births 1967-1993 (n = 1 548 429 linking the Medical Birth Registry of Norway (MBRN (exposure variables and the National Insurance Administration Register (NIAR (outcome variables, which covers all Norwegians. The MBRN variables included pregnancy complications, pregnancy outcomes and diseases of the mother. The NIAR provided data on all Norwegians who had received cash benefit for treatment of asthma from 1967 to 1996 (n = 5938, 3.9/1000 persons.Results  : In multiple logistic regression analysis, pregnancy complications (International Classification of Diseases (ICD-8 codes: 630-34 were associated with the risk of asthma (odds ratio 1.82, 95% confidence interval: 1.67–1.98. This was also the case if analyses were performed in different strata according to year of birth, plurality, maternal atopy, geographical district of birth, and maternal education.Conclusions  : Pregnancy complications may represent risk factors for the development of asthma in the offspring or express early signs of increased risk for developing the disease.: Svangerskapskomplikasjoner hos mor kan gi økt risiko for utvikling av astma hos barnet eller utrykke tidlige tegn på økt risiko for å utvikle sykdommen: Multipell logistisk regresjonsanalyse viste at svangerskapskomplikasjoner (International Classification of Diseases (ICD-8 kode 630-34 var assosiert med risikoen for å ha fått grunn- og/eller hjelpestønad for astma (odds ratio 1,82, 95% konfidensintervall: 1,67–1,98. Dette var også tilfelle hvis analysene ble utført i forskjellige strata av f

  1. A meta-heuristic cuckoo search and eigen permutation approach for ...

    Indian Academy of Sciences (India)

    Akhilesh Kumar Gupta

    2018-04-17

    Apr 17, 2018 ... system (HOS) into a simplified lower order model of rea- sonable accuracy by ..... dom walk whose flight step length is dependent on a power law formula often ..... In: IEEE International Conference on Electric. Power and Energy ... hybrid cuckoo search and genetic algorithm for reliability– redundancy ...

  2. The effects of real-time telemedicine video consultations between nurses and patients with severe Chronic Obstructive Pulmonary Disease (COPD)

    DEFF Research Database (Denmark)

    Sorknæs, Anne Dichmann

    Formålet med ph.d. studiet var at undersøge effekten af telekonsultationer som supplement til konventionel behandling sammenlignet med konventionel behandling hos udskrevne patienter med KOL med fokus på genindlæggelser, dødelighed, sundhedsøkonomi, sygeplejerskers og patienters oplevelse af tele...

  3. The Association between Perceived Stress and Mortality among People with Multimorbidity

    DEFF Research Database (Denmark)

    Prior, Anders; Fenger-Grøn, Morten; Larsen, Karen Kjær

    2016-01-01

    Multimorbiditet er udbredt i den danske befolkning og forbindes med dårligt mentalt helbred og høj mortalitet. Dette studie undersøger betydningen af psykisk velbefindende for prognosen hos personer med flere samtidige kroniske lidelser. Resultaterne viser, at personer med et højt selvrapporteret...

  4. Food as Social Markers: A Copenhagen Hospital 1800

    DEFF Research Database (Denmark)

    Hyldtoft, Ole

    2008-01-01

    Artiklen handler om de tydelige sociale markeringer ved valget af mad og drikke hos de enkelte samfundsgrupper i København omkring 1800. Hovedgrundlaget består af bevarede spisereglementer for ammer, jordemoderelever og fire typer af patienter på Den kgl. Fødsels- og Plejestiftelse i København i...

  5. Physical Activity Patterns in Patients with Alcohol Use Disorder

    DEFF Research Database (Denmark)

    Sari, Sengül; Bilberg, Randi Marie; Nielsen, Anette Søgaard

    2017-01-01

    Tværsnitsundersøgelsen beskriver de deltagende alkoholpatienters fysiske aktivitetsniveau ved behandlingsstart. Med denne undersøgelse havde vi til formål at opnå viden om sundhedsadfærden hos behandlingssøgende mennesker med et alkoholmisbrug. Hertil blev det internationale spørgeskema om fysisk...

  6. Louisiana Coastal Area, Louisiana. Freshwater Diversion to Barataria and Breton Sound Basins. Feasibility Study. Volume 1. Draft Main Report. Draft Environmental Impact Statement.

    Science.gov (United States)

    1984-09-01

    and fresh marshes. 5.2.8.3. The study arca saipports r ich popula tions of phytoplankton, zooplankton, bent hos, macroinvertebrates , and numerous small...Foundation and consists primarily of saline marsh with a net-work of bayous, ditches, and lagoons . Rabbit hunting is considered excellent in the area

  7. Kommentarer til arbejdsdokument ENV/04/27. Dokument fra "Antibiotic resistance marker genes working group"

    DEFF Research Database (Denmark)

    Kjellsson, Gøsta

    2012-01-01

    "DMU har modtaget og vurderet det fremsendte dokument ENV/04/27 og bilag (mail fra Skov- og Naturstyrelsen d. 14-10-2004) om anvendelsen af antibiotikaresistensmarkører (ARM) hos GMO. Vi har tidligere flere gange kommenteret anvendelsen af antibiotikaresistens (se f.eks. brev til Skov- og Naturst...

  8. ~haeochronnocytonna

    African Journals Online (AJOL)

    ~rominent symptoms in 9 patients; postural dizziness occurred ... by hypotension and pulmonary. ~edema, before operation. ... Departments of Medicine and Surgery, Baragwanath Hos-. P~tal and the ... E. PLANT, F.F.A.RA.G.S. ..... 16. Ingram RH, Braunwald E. Pulmonary oedema. In: Braunwald E, ed. Heart. Disease: A ...

  9. Netværksanbringelser

    DEFF Research Database (Denmark)

    Bonfils, Inge Storgaard; Mehlbye, Jill; Raft Andersen, Karen

    Socialt udsatte børn og unge kan have stor gavn af at blive anbragt i pleje hos nær familie eller venner. Men plejeforældrene skal uddannes og støttes mere, end de bliver i dag. Danmark kan lære af Norge og Sverie....

  10. Symptoms as the main problem

    DEFF Research Database (Denmark)

    Rosendal, Marianne; Carlsen, Anders Helles; Rask, Mette Troellund

    2016-01-01

    Dette studie undersøger tilfredsheden hos patienter, der blev afsluttet i almen praksis uden specifik diagnose, dvs. hvor lægen efter afsluttet konsultation kun kunne anføre "symptom" eller "problem" som slutdiagnose. Det drejer sig om ca. 1/3 af alle helbredsrelaterede konsultationer i almen...

  11. Panik i rummet

    DEFF Research Database (Denmark)

    Pedersen, Peter Ole

    2017-01-01

    Artikel om overvågning og film med fokus på den særlige Home invasion-genre, der er udbredt både i Hollywood-blockbusters, horrorfilm og moderne klassikere. Det psykologiske, statusmæssige og politiske aspekt hos husejeren diskuteres gennem David Finchers 2002-thriller Panic Room....

  12. Depression og placebo

    DEFF Research Database (Denmark)

    Christensen, Kaj Sparle

    2016-01-01

    Metaanalyser har længe dokumenteret, at effekten af behandling med antidepressive lægemidler er begrænset sammenlignet med effekten af placebobehandling. Antidepressive lægemidler er kun sikkert virksomme hos svært deprimerede personer. Psykoterapi og antidepressive lægemidler er lige effektive h...

  13. Survival and prognostic factors at time of diagnosis in high-grade appendicular osteosarcoma

    DEFF Research Database (Denmark)

    Colding-Rasmussen, Thomas; Thorn, Andrea Pohly; Horstmann, Peter

    2018-01-01

    BACKGROUND: Survival of patients with high-grade osteosarcoma (HOS), the most common primary bone cancer, has not improved significantly the last 30 years and the disease remains a major challenge. The purpose of this study is to evaluate survival in relation to prognostic factors at time of diag...

  14. Der kosmologische Gottesbeweis, die Kritik Kants und die Interpretation Løgstrups

    DEFF Research Database (Denmark)

    Andersen, Svend

    2012-01-01

    Det kosmologiske gudsbevis hos Thomas Aquinas og den danske rationalist Jens Kraft præsenteres. Elementer i Kants kritik omtales. Derefter gøres rede for K.E. Løgstrups karakteristik af Kants kritik som "kosmologisk religionsfilosofi" i modsætning til hans egen "fænomenologiske religionsfilosofi...

  15. Vores indtryks udtryk

    DEFF Research Database (Denmark)

    Hermann, Jesper

    2008-01-01

    William James' Principles of Psychology er mit udgangspunkt for at se sammenhængende på vore psykologiske funktioner som vores mentale forankring i verden. Hvordan kan vi, med støtte hos sprogforskeren Otto Jespersen, dernæst undersøge 'vores indtryks udtryk' (sprogpsykologiens genstand) som...

  16. Mulighedsrum

    DEFF Research Database (Denmark)

    Folkmann, Mads Nygaard

    2007-01-01

    proces af internalisering, der bl.a. skal ses på baggrund af Kants filosofi og den tyske idealisme og på baggrund af ideologien om bevidsthedens produktive imagination, som den f.eks. kommer til udtryk hos Coleridge i Biographia Literaria (1817). Kapitel 3 beskriver teorien bag de romantiske teksters...

  17. Recension Undervisa tillgängligt

    Directory of Open Access Journals (Sweden)

    Caroline Olsson

    2013-04-01

    Full Text Available Caroline Olsson recenserar:Undervisa tillgängligt! Pedagogiska strategier för att funktionsnedsättning hos studenter inte skall vara ett hinder för att genomföra studierna (2012, reviderad upplaga, av Ann-Sofie Henriksson, Uppsala universitet, 116 s. 

  18. Ave Maria

    DEFF Research Database (Denmark)

    Imer, Lisbeth

    2012-01-01

    På nationalmuseerne i Grønland og i Danmark ligger en guldgrube af indskrifter, som giver os en enestående mulighed for at beskrive skriftkulturen hos landbefolkningen i middelalderen. Fra nordbotidens Grønland (ca. 985-1450) stammer omkring 150 genstande med runer og latinske bogstaver, som vise...

  19. Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line

    International Nuclear Information System (INIS)

    Martins-Neves, Sara R; Lopes, Áurio O; Carmo, Anália do; Paiva, Artur A; Simões, Paulo C; Abrunhosa, Antero J; Gomes, Célia MF

    2012-01-01

    Osteosarcoma is a bone-forming tumor of mesenchymal origin that presents a clinical pattern that is consistent with the cancer stem cell model. Cells with stem-like properties (CSCs) have been identified in several tumors and hypothesized as the responsible for the relative resistance to therapy and tumor relapses. In this study, we aimed to identify and characterize CSCs populations in a human osteosarcoma cell line and to explore their role in the responsiveness to conventional therapies. CSCs were isolated from the human MNNG/HOS cell line using the sphere formation assay and characterized in terms of self-renewal, mesenchymal stem cell properties, expression of pluripotency markers and ABC transporters, metabolic activity and tumorigenicity. Cell's sensitivity to conventional chemotherapeutic agents and to irradiation was analyzed and related with cell cycle-induced alterations and apoptosis. The isolated CSCs were found to possess self-renewal and multipotential differentiation capabilities, express markers of pluripotent embryonic stem cells Oct4 and Nanog and the ABC transporters P-glycoprotein and BCRP, exhibit low metabolic activity and induce tumors in athymic mice. Compared with parental MNNG/HOS cells, CSCs were relatively more resistant to both chemotherapy and irradiation. None of the treatments have induced significant cell-cycle alterations and apoptosis in CSCs. MNNG/HOS osteosarcoma cells contain a stem-like cell population relatively resistant to conventional chemotherapeutic agents and irradiation. This resistant phenotype appears to be related with some stem features, namely the high expression of the drug efflux transporters P-glycoprotein and BCRP and their quiescent nature, which may provide a biological basis for resistance to therapy and recurrence commonly observed in osteosarcoma

  20. Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line

    Directory of Open Access Journals (Sweden)

    Martins-Neves Sara R

    2012-04-01

    Full Text Available Abstract Background Osteosarcoma is a bone-forming tumor of mesenchymal origin that presents a clinical pattern that is consistent with the cancer stem cell model. Cells with stem-like properties (CSCs have been identified in several tumors and hypothesized as the responsible for the relative resistance to therapy and tumor relapses. In this study, we aimed to identify and characterize CSCs populations in a human osteosarcoma cell line and to explore their role in the responsiveness to conventional therapies. Methods CSCs were isolated from the human MNNG/HOS cell line using the sphere formation assay and characterized in terms of self-renewal, mesenchymal stem cell properties, expression of pluripotency markers and ABC transporters, metabolic activity and tumorigenicity. Cell's sensitivity to conventional chemotherapeutic agents and to irradiation was analyzed and related with cell cycle-induced alterations and apoptosis. Results The isolated CSCs were found to possess self-renewal and multipotential differentiation capabilities, express markers of pluripotent embryonic stem cells Oct4 and Nanog and the ABC transporters P-glycoprotein and BCRP, exhibit low metabolic activity and induce tumors in athymic mice. Compared with parental MNNG/HOS cells, CSCs were relatively more resistant to both chemotherapy and irradiation. None of the treatments have induced significant cell-cycle alterations and apoptosis in CSCs. Conclusions MNNG/HOS osteosarcoma cells contain a stem-like cell population relatively resistant to conventional chemotherapeutic agents and irradiation. This resistant phenotype appears to be related with some stem features, namely the high expression of the drug efflux transporters P-glycoprotein and BCRP and their quiescent nature, which may provide a biological basis for resistance to therapy and recurrence commonly observed in osteosarcoma.

  1. Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Modulates Purinoceptor-Coupled Calcium Signaling and Murine Nociceptive Behavior.

    Science.gov (United States)

    Liu, Pei-Shan; Chueh, Sheau-Huei; Chen, Chin-Chu; Lee, Li-Ya; Shiu, Li-Yen

    2017-01-01

    Hericium erinaceus is well known for the neurotrophic effect it confers by promoting nerve growth factor biosynthesis. We discovered a novel bioactivity of H. erinaceus in its ability to suppress adenosine triphosphate (ATP)-induced calcium signaling in neuronal PC12 cells. ATP, known primarily as a neurotransmitter, also acts on purinoceptors (P2 purinergic receptor [P2R]) to generate the cellular calcium signaling and secretion that mediate P2R physiological manifestations, including pain. Chronic pain reduces quality of life. However, constant analgesic administration can cause liver and kidney injury, as well as loss of the analgesic effect because of desensitization. In this study we investigated the analgesic potential of H. erinaceus through measurements of ATP-induced Ca2+ signaling in cell lines and observation of pain behaviors in mice. In P2R-coupled Ca2+ signaling measurements, extracts of H. erinaceus mycelia (HEEs) blocked ATP-induced Ca2+ signaling in both rat PC12 cells and human HOS cells. HEEs completely blocked ATP-induced Ca2+ signaling in human HOS cells, suggesting that this effect of HEEs is exerted through the P2R subtypes present in HOS cells, which include the P2X4, P2X7, P2Y2, and P2Y4 subtypes. In observations of animal behavior during pain, HEEs significantly reduced heat-induced pain, including postponing both the tail-flick response to heat stimulation and the paw-lifting response to a hot plate. This study demonstrates novel characteristics of H. erinaceus in reducing nociceptive behavior and blocking the functional activity of P2R. Further studies are required to verify this linkage and its molecular mechanisms.

  2. Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines

    Science.gov (United States)

    Rojnik, Matija; Jevnikar, Zala; Mirkovic, Bojana; Janes, Damjan; Zidar, Nace; Kikelj, Danijel; Kos, Janko

    2011-01-01

    Background Cathepsin H is a cysteine protease considered to play a major role in tumor progression, however, its precise function in tumorigenesis is unclear. Cathepsin H was recently proposed to be involved in processing of bone morphogenetic protein 4 (BMP-4) in mice. In order to clarify whether cathepsin H also regulates BMP-4 in humans, its impact on BMP-4 expression, processing and degradation was investigated in prostate cancer (PC-3), osteosarcoma (HOS) and pro-monocytic (U937) human cell lines. Materials and methods BMP-4 expression was founded to be regulated by cathepsin H using PCR array technology and confirmed by real time PCR. Immunoassays including Western blot and confocal microscopy were used to evaluate the influence of cathepsin H on BMP-4 processing. Results In contrast to HOS, the expression of BMP-4 mRNA in U937 and PC3 cells was significantly decreased by cathepsin H. The different regulation of BMP-4 synthesis could be associated with the absence of the mature 28 kDa cathepsin H form in HOS cells, where only the intermediate 30 kDa form was observed. No co-localization of BMP-4 and cathepsin H was observed in human cell lines and the multistep processing of BMP-4 was not altered in the presence of specific cathepsin H inhibitor. Isolated cathepsin H does not cleave mature recombinant BMP-4, neither with its amino- nor its endopeptidase activity. Conclusions Our results exclude direct proteolytic processing of BMP-4 by cathepsin H, however, they provide support for its involvement in the regulation of BMP-4 expression. PMID:22933963

  3. Digitalisering af det historiske jernbanenetværk

    DEFF Research Database (Denmark)

    Fertner, Christian

    2012-01-01

    Centret for Strategisk Byforskning startede i marts 2012 et nyt forskningsprojekt, der omhandler udfordringer hos og fremtiden for danske stationsbyer. Som datagrundlag digitaliserede vi bl.a. det danske jernbane netværk, normal- og smalspor, siden 1847 i grove træk. Denne opgørelse vil vi i det ...

  4. Forskning i musikterapi - Retspsykiatri

    DEFF Research Database (Denmark)

    Frederiksen, Britta Vinkler; Ridder, Hanne Mette Ochsner; Pedersen, Liselotte

    2015-01-01

    Et stigende antal undersøgelser peger på en positiv effekt af musikterapi på stemning, tanker og indsigt, sociale kompetencer og udvikling af mestringsstrategier samt regulering af arousal og følelser hos retspsykiatriske patienter. Dog mangler der på nuværende tidpunkt tilstrækkeligt med...

  5. Quantitative evaluation of spasticity

    DEFF Research Database (Denmark)

    Lorentzen, Jakob

    opsummerer resultaterne fra fire studier, som havde til formål at kvantificere 1) en spinal mekanisme med relation til spasticitet Post Activation Depression (PAD) som er relevant for udviklingen af hyperrefleksi hos personer med spasticitet 2) forskelle i refleksaktivitet målt klinisk og med en kombineret...

  6. Unbiased estimates of number and size of rat dorsal root ganglion cells in studies of structure and cell survival

    DEFF Research Database (Denmark)

    Lamm, Trine Tandrup

    Neurodegenerative sygdomme er karakteriseret ved tab af nervefibre og nervecellelegemer. Tilstande med fysiske eller toksikologiske beskadigelser af de primære sensoriske nerveceller hos rotten har ofte været anvendt som model for forståelse af de processer, der fører til celledød eller -overleve...

  7. Fagdidaktik i teater og drama

    DEFF Research Database (Denmark)

    Krøgholt, Ida; Kirk, Hanne; Guldhammer, Astrid

    produkter med gennemslagskraft. ”Attack your competitors with innovation” lyder IKEAs salgsslogan, og hos IKEA bliver kunstfagenes kompetencer derfor brugt som en hård konkurrenceparameter. På den anden side er kunstfagene mere truet end nogensinde før, da deres plads på skoleskemaet løbende er blevet...

  8. Man er mere fri

    DEFF Research Database (Denmark)

    Berliner, Peter; Larsen, Line Natascha

    2010-01-01

    Artiklen belyser community psykologisk praksis gennem en præsentation af det community psykologiske perspektiv i psyko-sociale programmer, der iværksættes for at fremme mental og social trivsel hos individer,i familier og i lokalsamfund og netværk. Der gives en beskrivelse og analyse af projektet...

  9. 78 FR 48927 - Hours of Service of Drivers: U.S. Department of Defense (DOD); Application for Exemption

    Science.gov (United States)

    2013-08-12

    ... the minimum 30-minute rest break provision of the Agency's hours-of-service (HOS) regulations for... rest break requirements, provided they do not perform any other work during the break. FMCSA requests... reasons for denying or granting the application and, if granted, the name of the person or class of...

  10. Konglomerater i agro- og fødevareindustrien - et overstået kapitel?

    DEFF Research Database (Denmark)

    Hansen, Henning Otte

    2015-01-01

    det seneste har også DLG ændret kurs bort fra konglomerat-tankegangen. Konglomerater har indbyggede styrker og svagheder, så det er nødvendigt med en individuel vurdering i hvert enkelt tilfælde. Generelt er konglomerater dog lavt prissat, og deres afkast er mindre end afkastet hos sammenlignelige...

  11. An International Business Blunder: Fennia 1913-1916

    DEFF Research Database (Denmark)

    Pedersen, Kurt; Strandskov, Jesper; Sørensen, Peter

    2008-01-01

    En fremstilling af Otto Mønsted A/S finske datterselskab, født 1913 og afgået ved en kompliceret død tre år senere. Dertil en analyse på basis af begreber hentet hos Michael Porter samt Bartlett, Ghoshal og Nohria af ledelsesmæssige fejldispositioner....

  12. CrossTalk. The Journal of Defense Software Engineering. Volume 25, Number 1, Jan/Feb 2012

    Science.gov (United States)

    2012-01-01

    reap its full value. CrossTalk—January/February 2012 25 HIGH MATURITY - THE PAYOFF expanded target audience of producers, buyers, and users of...Grocery lists are longer than macaroni & cheese, diet Pepsi and Ho-Hos. • You have read this list, and realized that several items apply to you. And

  13. DUB-Projekt Morsø Kommune

    DEFF Research Database (Denmark)

    Nørgaard, Britta

    Formålet med evalueringen er at dokumentere ændringer, som projektdeltagelsen har medført hos projektdeltagerne, lige som der skal udvikles anbefalinger i forhold til udvikling af god praksis for arbejdet med udsatte børn. De overordnede evalueringsspørgsmål, der bliver styrende for evalueringen,...

  14. HIV-Sero- prevalence trend among blood donors in North East ...

    African Journals Online (AJOL)

    2017-09-03

    Sep 3, 2017 ... On the other hand, significantly declining fashion of. HIV seroprevalence were observed in the studies done in blood banks of Jimma University Specialized Hos- pital and Gonder University hospital7,8 and NorthWest. Ethiopia.9 The Federal Ministry of Health reported the. National HIV prevalence as 3.5% ...

  15. Exercise Training in Stable Heart Transplant recipients

    DEFF Research Database (Denmark)

    Dall, Christian Have

    Afhandlingen består af to forsøg, et randomiseret crossover forsøg der undersøger effekten af træning på hjertetransplanterede, samt et klinisk forsøg der undersøger akut blodtryksstigning ved styrketræning hos hjertetransplanterede, hjertesvigtspatienter, og patienter med iskæmisk hjertesygdom. ...

  16. Peter Nansen og Aalborg

    DEFF Research Database (Denmark)

    Bang, Karin

    2005-01-01

    Om Peter nansens tilknytning til Limfjordsegnen. Peter Nansen betragtede hele livet Aalborg som sin "hjemby" - det var her, han havde sin rod. Han kom til Aalborg som et-årig i april 1862, da hans far F.P.N. Nansen blev kapellan ved Budolfi Kirke. Mange af barndomsferierne tilbragte han hos sin...

  17. Den filosofiske krimi. Med særligt fokus på Henning Mortensens Sondrup-trilogi

    DEFF Research Database (Denmark)

    Hansen, Kim Toft

    2008-01-01

    Når man starter en roman med et citat af filosoffen Ludwig Wittgenstein, er tonen allerede slået an. Lader man dernæst en mand finde dolket, bliver det hurtigt tydeligt, hvor vi befinder os: kriminalromanens sprossede skygge. Men hos den danske forfatter Henning Mortensen falder skyggerne på en...

  18. May I come to visit you at work?

    DEFF Research Database (Denmark)

    Klausen, Bodil

    2016-01-01

    Artiklen beskriver faglige oplevelser fra et længerevarende studiebesøg, hvor en lektor har fulgt en praktiker - "shadowing". I dette tilfælde en irsk pædagog, der arbejder hos YAPS: Youth Action Project Sligo, der er et samarbejde mellem politiet og sociale myndigheder i forhold til unge mellem ...

  19. Introducing a patient-controlled analgesia-based acute pain ...

    African Journals Online (AJOL)

    say: 'The treatment of pain after surgery in British hos- pitals has been ... Senior registrars are assigned to share the service load. This enables .... The physiotherapists are active supporrers ofthe. APRS. ... of the registrars fall ill or take leave. Consultant .... raises the importance ofpain prevention in the minds of all clinical ...

  20. Skrivehandlinger som redskab til klar faglig formidling på PharmaSchool

    DEFF Research Database (Denmark)

    Laursen, Katja Årosin

    2016-01-01

    Denne artikel beskriver et pilotprojekt fra 2013, som havde til formål at øge opmærksomheden på klar skriftlig faglig formidling hos undervisere og studerende i kurset Dynamisk Biokemi på PharmaSchool ved Københavns Universitet (KU). På baggrund af en grundig behovsafdækning udviklede en akademisk...

  1. Gyrodactylus salaris

    DEFF Research Database (Denmark)

    Heinecke, Rasmus Demuth; Jørgensen, Louise von Gersdorff; Bresciani, José

    2006-01-01

    Gyrodactylus salaris er en lille snylter, der angriber laksefiskenes hud og finner, hvilket kan medføre betydelig sygdom og dødelighed hos angrebne fisk. En særlig aggressiv type af denne snylter-art har decimeret bestanden af vildlaks i 45 norske elve siden 1970'erne. Snylteren forekommer også i...

  2. Fatal Klippel-Trenaunay syndrome in a child with pulmonary embolism

    DEFF Research Database (Denmark)

    Pedersen, Rie Skovgaard; Hedelund, Lene; Poulsen, Lone H

    2013-01-01

    Klippel-Trénaunays syndrom (KTS) er en sjælden, medfødt sygdom, der er kendetegnet ved venøse malformationer (VM), kutane kapillære malformationer og overvækst af bløddele og/eller knogler [1]. Forekomst af hyperkoagulabilitet, trombosering og lungeemboli er tidligere beskrevet hos patienter med ...

  3. Freire and Danish social pedagogy

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal

    2015-01-01

    Kapitlet viser Freires betydning for dansk socialpædagogik - både i snævrere forstand (anderledes pædagogik på døgninstitutioner og fællesskaber) og i bredere forstand (voksenoplysning). Her knyttes an til reformpædagogikken, som den udfoldedes efter 2. verdenskrig, og grundtankerne hos Freire un...

  4. Musikterapi med kontakt- og kommunikationssvage børn

    DEFF Research Database (Denmark)

    Frederiksen, Britta Vinkler

    2009-01-01

    I artiklen beskrives, hvordan musikterapi er med til at støtte en målrettet udviklingsproces hos børn, med diagnoser som Asperger syndrom, autisme, opmærksomhedsforstyrrelser, ADHD o.lign. Musikkens kvaliteter beskrives og illustreres gennem vignetter fra terapiforløb, der alle er foregået i Klinik...

  5. Forskning i musikterapi - børn med en Autisme Spektrum Forstyrrelse

    DEFF Research Database (Denmark)

    Holck, Ulla

    2011-01-01

    Der er forskningsmæssig evidens for, at musikterapi med børn med en autisme spektrum forstyrrelse (ASF) har en signifikant effekt. Cochrane reviews påviser, at musikterapi fremmer verbal og navnlig nonverbal kommunikation hos børn med ASF. En RCT-undersøgelse viser endvidere en signifikant effekt...

  6. Grasping the Existential Experience of Living with Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Larsen, Janni Lisander

    Dette projekt havde til formål at undersøge eksistentielle vilkår hos kvinder med sygdommen, systemisk lupus erythematosus, herunder hvordan disse vilkår blev erfaret gennem et langvarigt sygdomsforløb. Data blev konstrueret gennem 3 konsekutive, personlige interview sessions på dag 0, efter 6 og...

  7. A study of young Parisian speech

    DEFF Research Database (Denmark)

    Hansen, Anita Berit

    2012-01-01

    Fransk talt i Paris har gennem århundrede udgjort en model for den øvrige franske befolkning. Udtalen er dog på ingen måde fri for variation eller forandring. Artiklen behandler udtalen hos 9 unge parisere (såvel studerende som personer med kort teknisk uddannelse), der tydeligvis deltager i flere...

  8. Physical Exercise and Multiple Sclerosis

    DEFF Research Database (Denmark)

    Dalgas, Ulrik

    Baggrund: Kun få ikke-kontrollerede studier har undersøgt effekten af progressive styrketræning hos patienter med multipel sklerose (MS).  Formål: Undersøgelsens formål var at teste om progressiv styrketræning (PRT) af benene forbedrer muskelstyrke, muskelmorfologi, funktionel kapacitet, træthed,...

  9. Computer Aided Design i England

    DEFF Research Database (Denmark)

    Sigrist, F.; Agger, K.; Barfoed, P.

    Meddelelsen redegør for en række besøg hos engelske systemleverandører og brugere. Seks forskellige CAD-systemer vurderes på baggrund af deres brug i praksis, og valget af to systemer til afprøvning i Danmark begrundes. Desuden bringes generelle konklusioner om CAD-systemernes aktuelle udviklings...

  10. Tracking of physical activity, physical fitness and body mass index from childhood to adolescence

    DEFF Research Database (Denmark)

    Kristensen, Peter Lund

    2007-01-01

    Kardiovaskulære sygdomme er blandt de væsentligste dødsårsager i det moderne vestlige samfund. Sygdommene observeres almindeligvis kun hos voksne, men den almene sundhedstilstand og sundhedsadfærd i barndommen anses for at spille en væsentlig rolle i udviklingen af disse sygdomme. Tidligere studi...

  11. Rehabilitering og 'motion på recept'

    DEFF Research Database (Denmark)

    Larsen, Niels Sandholm; Larsen, Kristian

    2008-01-01

    af disse forskningsarbejder er etablering af fænomenet 'motion på recept'. Konceptet om 'motion på recept' stammer oprindelig fra Sverige, hvor praktiserende læger i en periode har haft mulighed for at henvise visse typer af patienter til fysisk træning hos praktiserende fysioterapeuter. Ribe Amt...... 2007)....

  12. Midler til lindring af mundtørhed og stimulation af spytsekretion

    DEFF Research Database (Denmark)

    Dynesen, Anja Weirsøe; Pedersen, Anne Marie Lynge; Jensen, Allan Bardow

    2013-01-01

    effekt. I relation til risikoen for at udvikle caries, der er forhøjet hos den mundtørre patient, er det dog væsentligt at anbefale produkter uden sukker. Ligesom produktets indhold af syre og dermed det erosive potentiale er af betydning i forhold til udviklingen af dentale erosioner. Systemisk...

  13. CrossTalk: The Journal of Defense Software Engineering. Volume 25, Number 1, January/February 2012

    Science.gov (United States)

    2012-02-01

    February 2012 25 HIGH MATURITY - THE PAYOFF expanded target audience of producers, buyers, and users of software products and systems bring with it...diet Pepsi and Ho-Hos. • You have read this list, and realized that several items apply to you. And it got less and less funny as you kept

  14. Pharmacogenetic investigations with special reference to forensic medicine

    DEFF Research Database (Denmark)

    Buchard, Anders

    Dansk Resumé Mennesker reagerer forskelligt på lægemidler. Den samme dosis af et givent lægemiddel vil hos nogle individer resultere i bivirkninger, mens andre vil opleve ringe eller ingen effekt. Der kan være mange årsager til dette, bl.a. genetiske forskelle mellem individer. Farmakogenetik kan...

  15. Inkluderende specialpædagogik

    DEFF Research Database (Denmark)

    Hedegaard-Sørensen, Lotte

    Bogen præsenterer en pædagogisk og didaktisk tilgang til inklusion, der inddrager specialpædagogisk viden, der tidligere hørte specialpædagogiske institutioner til. Der er ikke tale om specialpædagogiske teorier og modeller, der kompenserer for mangler hos fx diagnostiserede børn, men om en...

  16. Ventrikulaere takyarytmier hos patienter med kardiomyopati

    DEFF Research Database (Denmark)

    Henningsen, Kristoffer; Christensen, Alex Hørby; Svendsen, Jesper Hastrup

    2008-01-01

    by disease, gender, age, previous cardiac arrest and treatment with implantable cardioverter-defibrillator (ICD). RESULTS: 993 patients were screened and 128 patients with cardiomyopathy were identified, corresponding to 13% of the screened patients. 58 (45%) of the patients had dilated cardiomyopathy (DCM......), 57 (45%) patients had arrhythmogenic right ventricular cardiomyopathy (ARVC) and 13 (10%) had hypertrophic cardiomyopathy (HCM). The average age was 44 years for HCM, 41 years for ARVC and 58 years for DCM. The majority of the patients were male. ICD treatment was used in 95% of the patients...... with ARVC, 70% of the patients with HCM and 59% of the patients with DCM. Only 5 patients had previous cardiac arrest without reversible cause. CONCLUSION: The study shows that cardiomyopathies are relatively frequent causes of ventricular tachyarrhythmias in patients discharged from a specialised...

  17. Nekrotiserende fasciitis hos børn

    DEFF Research Database (Denmark)

    Jensen, Karsten Gjessing; Kristensen, Kim

    2009-01-01

    Necrotizing fasciitis (NF) is a serious condition with infection of the muscular fascia causing rapidly spreading necrosis. NF rarely affects children, and we here report two paediatric cases of NF. The first developed NF after a joint puncture, the other after surgical extirpation of a lymph node...

  18. Diffus lungesygdom hos børn

    DEFF Research Database (Denmark)

    Buchvald, Frederik; Nielsen, Kim G

    2014-01-01

    Diffuse lung disease in children represents a heterogeneous group of respiratory disorders with high morbidity and mortality. Typical features include tachypnoea, failure to thrive, diffuse radiological and histopathological abnormalities. Advances in genetics and pathophysiology, combined...

  19. Fritids- og sportsaktiviteter hos yngre pacemakerpatienter

    DEFF Research Database (Denmark)

    Mickley, H; Petersen, J

    1989-01-01

    : Badminton (3), bicycle-riding (6), firefighting (1), fishing (3), golf (2), gymnastics (3), handball (1), hunting (4), riding (1), running/jogging (4), sailing (5), shooting (2), skiing (3), soccer (5), swimming (1), theatre (1), chorus (1), and tennis (2). No significant changes in the levels of activity...

  20. SWAY Bæredygtighed hos SMV'er

    DEFF Research Database (Denmark)

    2016-01-01

    Valg af materiale/medie/form: SWAY der indeholder forskelligt materiale Valg af arbejdsform: Kan anvendes som et element i undervisning eller indlæg Begrundelse for valg af materiale/medie/form/arbejdsform: Forskelligt materiale kan samlet heri og det kan tilgås af alle via linket...

  1. Demens hos personer med Downs syndrom

    DEFF Research Database (Denmark)

    Salem, Lise Cronberg; Jørgensen, Kasper

    2014-01-01

    In developed countries the population of elderly people with Down syndrome expands resulting in an increasing incidence of age-related diseases, including dementia. The assessment of dementia in individuals with intellectual disability is often complicated due to large intra-individual variability...

  2. Spiritualitet som coping hos tibetanske torturoverlevere

    DEFF Research Database (Denmark)

    Elsass, Peter; Carlsson, Jessica; Husum, Kristian

    2010-01-01

    INTRODUCTION: There is solid documentation for the positive relationship between spirituality and health, but few examples of how this link may be used in projects of rehabilitation after war, civil conflicts and natural disasters. One such example is the Danida funded Tibetan Torture Program...... in India. This study aims to provide evidence of the Tibetan torture survivors' degree of traumatisation and their use of spirituality to overcome their difficult situation. MATERIAL AND METHODS: The study consists of an assessment and a rehabilitation part. A total of 102 Tibetan torture survivors were...

  3. Læringsmodstand hos børn

    DEFF Research Database (Denmark)

    Broström, Stig

    2017-01-01

    I dette kapitel beskrives dimensioner ved børns læring og med særligt fokus på Illeris’ begreb læringsmodstand. Det tages udgangspunkt i den kulturhistoriske skoles læringsteori med reference til bl.a. Vygotsky og Leontjev. Børn i såvel dagtilbud som skolen vil løbende vise modstand mod læring. D...

  4. Demens hos personer med Downs syndrom

    DEFF Research Database (Denmark)

    Salem, Lise Cronberg; Jørgensen, Kasper

    2014-01-01

    In developed countries the population of elderly people with Down syndrome expands resulting in an increasing incidence of age-related diseases, including dementia. The assessment of dementia in individuals with intellectual disability is often complicated due to large intra-individual variability...... in cognitive functioning prior to dementia and to lack of standardised measures to detect dementia. Structured observations of symptoms of dementia and assessment techniques tailored for people with intellectual disability are increasingly needed....

  5. Lungeinfektioner er hyppige hos ældre

    DEFF Research Database (Denmark)

    Laut, Kamilla; Benfield, Thomas

    2013-01-01

    There are over 20,000 hospital admissions for pneumonia annually in Denmark. The incidence of pneumonia increases with age, functional impairment and co-morbidity. In fact, 60% of admissions occur among persons 65 years or older. The public health burden is expected to increase because this popul......, smoking cessation, mobilization and oral hygiene....

  6. Naturligt forekommende oseltamivirresistens hos influenza A

    DEFF Research Database (Denmark)

    Madsen, Laura; Nielsen, Alex; Lundgren, Jens

    2010-01-01

    in the development of resistance. The best prevention strategy remains vaccination of the general population to avoid immunity. Future antiviral treatment calls for knowledge about resistance to existing types of influenza and the availability of all three types of antiviral medication.......During the last two influenza seasons, one of the predominant influenza A types (H1N1) has developed complete resistance to oseltamivir, the primary treatment option. The virus does, however, remain sensitive to zanamavir and amantadine. There is no unequivocal explanation for this slide...

  7. Eosinofil cystitis hos børn

    DEFF Research Database (Denmark)

    Kvist, K; Cortes, D; Visfeldt, J

    1999-01-01

    Eosinophilic cystitis is an inflammatory disorder of the urinary bladder, characterised by irritative voiding symptoms, negative urine cultures, and eosinophilic infiltration of the bladder wall. Since 1960 only about 20 cases have been described in the English scientific reports, making it a rat......Eosinophilic cystitis is an inflammatory disorder of the urinary bladder, characterised by irritative voiding symptoms, negative urine cultures, and eosinophilic infiltration of the bladder wall. Since 1960 only about 20 cases have been described in the English scientific reports, making...... it a rather rare entity. In children the disease appears to be shortlived and self-limited, requiring no specific treatment. We present a case with a 7.5-year-old boy, who experienced spontaneous remission of all symptoms, following an acute attack of eosinophilic cystitis....

  8. Akut svimmelhed hos den neurologiske patient

    DEFF Research Database (Denmark)

    Bruun, Marie; Højgaard, Joan L. Sunnleyg; Kondziella, Daniel

    2013-01-01

    Acute vertigo of neurological origin may be caused by haemorrhages and tumours in the posterior fossa and, most frequently, by ischaemic infarction in the vertebrobasilar circulation. Urgent diagnosis is necessary to avoid further ischaemic episodes, herniation due to cerebellar oedema and/or fatal...... brainstem infarction. The history should focus on accompanying neurological symptoms. However, vertigo with cerebellar lesions may be monosymptomatic and then bedside evaluation of oculomotor function is the key to correct diagnosis. This paper discusses the pathophysiology, symptomatology and clinical...... evaluation of acute vertigo of neurological origin....

  9. Jyske banker til kaffe hos Lizette

    DEFF Research Database (Denmark)

    Ørholst, Henrik

    2018-01-01

    En fusion mellem Sydbank, Jyske Bank og Spar Nord vil kunne skabe et stærkt alternativ til Danske Bank og Nordea, men det er næppe realistisk. Her kunne bankerne lære noget af LO og FTF.......En fusion mellem Sydbank, Jyske Bank og Spar Nord vil kunne skabe et stærkt alternativ til Danske Bank og Nordea, men det er næppe realistisk. Her kunne bankerne lære noget af LO og FTF....

  10. Demenslidelser hos ældre tyrkiske indvandrere

    DEFF Research Database (Denmark)

    Rosenbaum, B.; Kristensen, M.; Schmidt, J.

    2008-01-01

    INTRODUCTION: The health condition in a population of elderly Turkish immigrants is investigated with special focus on dementia conditions. The possibility to use the screening test Mini Mental State Examination (MMSE) in relation to the investigated population is evaluated as well as their future...

  11. MBHI hos patienter med kroniske rygsmerter

    DEFF Research Database (Denmark)

    Simonsen, Erik; Kastberg, S.; Jensen, Hans Henrik

    1991-01-01

    Studied the predictive validity of the MBHI (T. Millon et al, 1982) and analyzed the differences in personality and attitudes between patients with chronic lower-back pain and patients with acute pain. Human Ss: 26 male and female adults (aged 28–60 yrs) (chronic lower-back pain); 24 male and fem...... of treatment to determine the extent of the success of the therapy. The actual success of the therapy was compared with the predictions for success based on the MBHI results. (English abstract) (PsycINFO Database Record (c) 2012 APA, all rights reserved)...

  12. Kirurgisk behandling af urininkontinens hos kvinder

    DEFF Research Database (Denmark)

    Ammendrup, A.C.; Sørensen, Helle Christina; Sander, Pia

    2010-01-01

    : In total, 94 operating gynaecologists and urologists were identified, 63 responded (71%) of whom 49 (78%) performed UI surgery. UI surgeons were gynaecologists 43 (88%) of these 24 (49%) were urogynecologists (working more than 50% with urogynecology) and five (10%) urologists. Tension-free Vaginal Tape......INTRODUCTION: During the last decade, minimal invasive procedures have been introduced for treatment of urinary incontinence (UI) in women leading to shorter hospitalisation and fewer complications. The aim of this study was to outline clinical practice and attitudes among Danish UI surgeons....... MATERIAL AND METHODS: Surgeons performing UI procedures were identified and mailed a questionnaire in 2007 concerning 2006. Questions included specialisation, number of procedures, type of surgery, complications and attitude towards learning surgery and maintaining a sufficient level of routine. RESULTS...

  13. Staphylococcal scalded skin syndrome hos voksne

    DEFF Research Database (Denmark)

    Mikkelsen, Carsten Sauer; Mikkelsen, Dorthe Bisgaard; Jensen, Thøger Gorm

    2010-01-01

    parts of her body. The bullae ruptured easily and left a erythematous base. The histopathological changes were characteristic for adult SSSS. The patient was well-treated with intravenous dicloxacillin, topical antibiotic and antiseptic treatment. The patient had marked thrombocytosis, but no interest...

  14. Immunmedieret perikarditis hos patient med meningokokmeningitis

    DEFF Research Database (Denmark)

    Fuglsang Hansen, Janne; Johansen, Isik Somuncu

    2014-01-01

    Extrameningial manifestations in patients with meningococcal meningitis are rare. One of these manifestations is immune-mediated or purulent pericarditis. We present a case where a patient with meningococcal meningitis developed pericarditis on the 11th day after admission. A pericardial puncture...

  15. Spiritualitet som coping hos tibetanske torturoverlevere

    DEFF Research Database (Denmark)

    Elsass, Peter; Carlsson, Jessica; Husum, Kristian

    2010-01-01

    INTRODUCTION: There is solid documentation for the positive relationship between spirituality and health, but few examples of how this link may be used in projects of rehabilitation after war, civil conflicts and natural disasters. One such example is the Danida funded Tibetan Torture Program...

  16. Identitetskonstruktion hos unge poly-linguale sprogere

    DEFF Research Database (Denmark)

    Stæhr, Andreas

    2010-01-01

    I denne artikel belyser jeg, hvordan henholdsvis fler- og mindretals unge konstruerer, tilskriver og forhandler identiteter i interaktionen med hinanden. Karakteristisk, for de unge jeg fokuserer på, er, at de i deres identitetsarbejde ikke kun positionerer sig i lokalt i forhold til hinanden, men...... også positionerer sig i forhold til andre aktører eller grupper i samfundet. Eksempelvis viser jeg, hvordan de unges viden om stereotype forestillinger om minoritetsgrupper i det danske samfund kommer til at spille en afgørende rolle for deres identitetsarbejde. Ligeledes viser jeg, hvordan...

  17. Sprogbrug og identitetsarbejde hos senmoderne storbypiger

    DEFF Research Database (Denmark)

    Ag, Astrid

    , afgrænselige størrelser, men derimod sproglige træk. Undersøgelsen viser også, at pigerne kender til de sociokulturelt baserede grænser mellem såkaldte nationalsprog, men at det ikke nødvendigvis betyder, at de tager dem alvorligt. Gennem analyser af pigernes interaktionelle konstruktioner af identiteter og...... forhandlinger af sociale relationer viser undersøgelsen, at pigerne, både hvad angår kønsaspekter og etnicitetsaspekter i deres identitetskonstruktioner, trækker på en bredere vifte af ressourcer, end hvad stereotype beskrivelser normalt indikerer. Pigerne bryder, udnytter og navigerer således mellem...... forskellige stereotype konstruktioner i deres identitetsarbejde. Det samme gør de, når de anvender træk tilskrevet senmoderne urban ungdomsstil, og når de taler det, de selv refererer til som ”integreret”. Bogen konkluderer, at de tre senmoderne storbypiger har en bred vifte af sproglige ressourcer til...

  18. Kirurgisk behandling af urininkontinens hos kvinder

    DEFF Research Database (Denmark)

    Ammendrup, Astrid Cecilie; Sørensen, Helle Christina; Sander, Pia

    2010-01-01

    (TVT) was the preferred sling in 2006. A total of 20 (47%) UI surgeons used only TVT, seven (17%) only transobturator slings (TOS) and 15 (36%) both TVT and TOS. Only 11 (24%) performed > 25 TVT per year and 11 (27%) performed > 25 TOS per year. In all, UI surgeons had experience with ten different...

  19. Naturligt forekommende oseltamivirresistens hos influenza A

    DEFF Research Database (Denmark)

    Madsen, Laura; Nielsen, Alex; Lundgren, Jens

    2010-01-01

    During the last two influenza seasons, one of the predominant influenza A types (H1N1) has developed complete resistance to oseltamivir, the primary treatment option. The virus does, however, remain sensitive to zanamavir and amantadine. There is no unequivocal explanation for this slide...... in the development of resistance. The best prevention strategy remains vaccination of the general population to avoid immunity. Future antiviral treatment calls for knowledge about resistance to existing types of influenza and the availability of all three types of antiviral medication....

  20. Sundhedsloven og sundhedsydelser hos udokumenterede migranter

    DEFF Research Database (Denmark)

    Aabenhus, Rune Munck; Hallas, Peter

    2012-01-01

    Health-care workers may experience uncertainty regarding legal matters when attending to medical needs of undocumented migrants. This paper applies a pragmatic focus when addressing the legal aspects involved in providing health-care services to undocumented migrants with examples from the Danish...

  1. Hepatitis B hos børn

    DEFF Research Database (Denmark)

    Christensen, Vibeke Brix; Nordly, Sannie Brit; Kjær, Mette

    2014-01-01

    Chronic hepatitis B (HBV) infection is seen in 400 million persons worldwide. HBV is transmitted vertically or horizontally by infected blood and body fluids. An effective vaccine exists. Most children develop a chronic HBV infection if infected early in life. They are often in an immune-tolerant......Chronic hepatitis B (HBV) infection is seen in 400 million persons worldwide. HBV is transmitted vertically or horizontally by infected blood and body fluids. An effective vaccine exists. Most children develop a chronic HBV infection if infected early in life. They are often in an immune...

  2. Obstetriske komplikationer hos kvinder med endometriose

    DEFF Research Database (Denmark)

    Berlac, Janne Foss; Hartwell, Dorthe; Langhoff-Roos, Jens

    2014-01-01

    Approximately 5-10% of the women in the reproductive age are afflicted with endometriosis and many become pregnant after fertility treatment. Women with endometriosis seem to have an increased risk of placental complications, bleeding in pregnancy and during labour as well as possible increased...... risk of pre-eclampsia, preterm birth and low birthweight. Large epidemiological studies are needed to clarify the magnitude of these risks in order to define the appropriate level of proactive management of pregnant women with endometriosis....

  3. Obstetriske komplikationer hos kvinder med endometriose

    DEFF Research Database (Denmark)

    Berlac, Janne Foss; Hartwell, Dorthe; Langhoff-Roos, Jens

    2014-01-01

    Approximately 5-10% of the women in the reproductive age are afflicted with endometriosis and many become pregnant after fertility treatment. Women with endometriosis seem to have an increased risk of placental complications, bleeding in pregnancy and during labour as well as possible increased r...

  4. Intervertebral diskitis hos børn

    DEFF Research Database (Denmark)

    Benhassen, Leila Louise; Balslev, Thomas; Gammelgaard, Lise

    2016-01-01

    but infectious, and inflammatory aetiologies have been suggested. Diagnostic golden standard is magnetic resonance imaging. The treatment is immobilization, anti-inflammatory drugs and often antibiotics. Early treatment is important to reduce the risk of complications such as nerve damage and spine fusion....

  5. Hepatitis C hos børn

    DEFF Research Database (Denmark)

    Christensen, Vibeke Brix; Nordly, Sannie Brit; Fischler, Bjørn

    2014-01-01

    Chronic hepatitis C (HCV) infection has a prevalence of 2-3% worldwide. The vertical transmission rate is approximately 5%. There is no evidence to recommend abstinence from breastfeeding or elective C-section to prevent transmission. In children, the natural history of HCV infection is typically...

  6. In vitro evaluation of biomimetic chitosan–calcium phosphate scaffolds with potential application in bone tissue engineering

    International Nuclear Information System (INIS)

    Tanase, C E; Popa, M I; Sartoris, A; Unger, R E; Kirkpatrick, C J; Verestiuc, L

    2013-01-01

    This work reports on the physicochemical properties and in vitro cytotoxicity assessment of chitosan–calcium phosphate (Cs–CP) scaffolds for bone tissue engineering, which were synthesized by a novel biomimetic co-precipitation method. X-ray diffraction (XRD) along with scanning electron microscopy (SEM) analysis confirmed the porous morphology of the scaffolds and the amorphous nature of the inorganic phase with different crystallite sizes and the formation of various forms of calcium phosphate. Compressive mechanical testing revealed that the Young's modulus of the biomaterials is in the range of human trabecular bone. In vitro tests were performed on the biomaterials for up to 14 days to study the behavior of the osteoblast-like human cell line (MG63), primary human osteoblasts (HOS) and human dermal microvascular endothelial cells (HDMEC). The cytotoxicity was evaluated by the MTS assay for cell metabolism and the detection of membrane integrity (lactate dehydrogenase-LDH release). An expression of the vascular endothelial growth factor (VEGF) in the cell supernatants was quantified by ELISA. Cell viability gave values close to untreated controls for MG63 and HOS, while in the case of HDMEC the viability after 2 weeks in the cell culture was between 80–90%. The cytotoxicity induced by the Cs–CP scaffolds on MG63, HOS and HDMEC in vitro was evaluated by the amount of LDH released, which is a sensitive and accurate marker for cellular toxicity. The increased levels of VEGF obtained in the osteoblast culture highlights its important role in the regulation of vascularization and bone remodeling. The biological responses of the Cs–CP scaffolds demonstrate a similar proliferation and differentiation characteristics of the cells comparable to the controls. These results reveal that biomimetic Cs–CP composite scaffolds are promising biomaterials for bone tissue engineering; their in vivo response remains to be tested. (paper)

  7. Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma.

    Science.gov (United States)

    Daft, Paul G; Yuan, Kaiyu; Warram, Jason M; Klein, Michael J; Siegal, Gene P; Zayzafoon, Majd

    2013-04-01

    Osteosarcoma is among the most frequently occurring primary bone tumors, primarily affecting adolescents and young adults. Despite improvements in osteosarcoma treatment, more specific molecular targets are needed as potential therapeutic options. One target of interest is α-Ca(2+)/calmodulin-dependent protein kinase II (α-CaMKII), a ubiquitous mediator of Ca(2+)-linked signaling, which has been shown to regulate tumor cell proliferation and differentiation. Here, we investigate the role of α-CaMKII in the growth and tumorigenicity of human osteosarcoma. We show that α-CaMKII is highly expressed in primary osteosarcoma tissue derived from 114 patients, and is expressed in varying levels in different human osteosarcoma (OS) cell lines [MG-63, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)/HOS, and 143B). To examine whether α-CaMKII regulates osteosarcoma tumorigenic properties, we genetically inhibited α-CaMKII in two osteosarcoma cell lines using two different α-CaMKII shRNAs delivered by lentiviral vectors and overexpressed α-CaMKII by retrovirus. The genetic deletion of α-CaMKII by short hairpin RNA (shRNA) in MG-63 and 143B cells resulted in decreased proliferation (50% and 41%), migration (22% and 25%), and invasion (95% and 90%), respectively. The overexpression of α-CaMKII in HOS cells resulted in increased proliferation (240%), migration (640%), and invasion (10,000%). Furthermore, α-CaMKII deletion in MG-63 cells significantly reduced tumor burden in vivo (65%), whereas α-CaMKII overexpression resulted in tumor formation in a previously nontumor forming osteosarcoma cell line (HOS). Our results suggest that α-CaMKII plays a critical role in determining the aggressive phenotype of osteosarcoma, and its inhibition could be an attractive therapeutic target to combat this devastating adolescent disease. ©2013 AACR.

  8. Zoledronic acid at subtoxic dose extends osteoblastic stage span of primary human osteoblasts.

    Science.gov (United States)

    Zara, Susi; De Colli, Marianna; di Giacomo, Viviana; Zizzari, Vincenzo Luca; Di Nisio, Chiara; Di Tore, Umberto; Salini, Vincenzo; Gallorini, Marialucia; Tetè, Stefano; Cataldi, Amelia

    2015-04-01

    This study aimed to check the effect of zoledronic acid (ZA) at subtoxic dose on human osteoblasts (HOs) in terms of cell viability, apoptosis occurrence, and differentiation induction. ZA belongs to the family of bisphosphonates (BPs), largely used in the clinical practice for the treatment of bone diseases, often associated with jaw osteonecrosis onset. Their pharmacological action consists in the direct block of the osteoclast-mediated bone resorption along with indirect action on osteoblasts. HOs were treated choosing the highest limit concentration (10(-5) M) which does not induce toxic effects. Live/dead staining, flow cytometry, mitochondrial membrane potential assay, osteocalcin western blotting, gp38 RT-PCR, collagen type I, PGE2, and IL-6 ELISA assays were performed. Similar viability level between control and ZA-treated samples is found along with no significant increase of apoptotic and necrotic cells in ZA-treated sample. To establish if an early apoptotic pathway was triggered, Bax expression and mitochondrial membrane potential were evaluated finding a higher protein expression in control sample and a good integrity of mitochondrial membrane in both experimental points. Type I collagen secretion and alkaline phosphatase (ALP) activity appear increased in ZA-treated sample, osteocalcin expression level is reduced in ZA-treated cells, whereas no modifications of gp38 mRNA level are evidenced. No statistical differences are identified in PGE2 secretion level whereas IL-6 secretion is lower in ZA-treated HOs with respect to control ones. These results highlight that ZA, delaying the osteoblastic differentiation process versus the osteocytic lineage, strengthens its pharmacological activity enhancing bone density. The knowledge of ZA effects on osteoblasts at subtoxic dose allows to improve therapeutic protocols in order to strengthen drug pharmacological activity through a combined action on both osteoclastic and osteoblastic cells.

  9. Bliv klogere på Mycoplasma bovis - Beslægtethed blandt de danske stammer: Afsløret

    DEFF Research Database (Denmark)

    Kokotovic, Branko

    Baggrund Bakterier tilhørende slægten Mycoplasma er årsag til forskellige sygdomme hos husdyr. De påvirker dyrenes velfærd samt fører til øgede produktionsomkostninger og betydelige økonomiske tab. I kvægbruget er en af de mest betydningsfulde mykoplasma på verdensplan Mycoplasma bovis, (M...

  10. Dada som spontaneitetens Gesamtkunstwerk

    DEFF Research Database (Denmark)

    Munch, Anders V.

    2008-01-01

    dadaseancerne var at skabe en ny umiddelbar sammehæng i kunsten eller ligefrem en spontan forening af kunstarterne. Artiklen undersøger det spørgsmål i en sammenligning med kunstsynet hos Richard Wagner og Friedrich W. Nietzsche. Den er et afsnit fra den endnu upublicerede afhandling, Fra Bayreuth til Bauhaus...

  11. Symposium on Command and Control Research (1988) Held in Monterey, California on Jun 7-9, 1988

    Science.gov (United States)

    1988-09-30

    ELa -1cl~ca aya Display: Show-Icon Show-Overlay-icons Erase-icon Eras e.Overlay-icons Highlight: Highlight-Icon Highlight-Overlay-icons Dehighlight...poanrtiso duty hosirs, for the esastesov 5: ’Referencescomptia. Peacetinme diary hos; are trin lsoors a day’,r days ank.Note that thiscanoles os6sio4- to heo

  12. History of Science Content Analysis of Chinese Science Textbooks from the Perspective of Acculturation

    Science.gov (United States)

    Ma, Yongjun; Wan, Yanlan

    2017-01-01

    Based on previous international studies, a content analysis scheme has been designed and used from the perspective of culture to study the history of science (HOS) in science textbooks. Nineteen sets of Chinese science textbooks have been analyzed. It has been found that there are noticeable changes in the quantity, content, layout, presentation,…

  13. Stress i gymnasiet

    DEFF Research Database (Denmark)

    Nielsen, Anne Maj; Lagermann, Laila Colding

    Denne undersøgelse af stress hos gymnasieelever i Aalborg viser, hvordan stress giver sig udslag i gymnasiet, hvad der stresser eleverne, hvad der adskiller de stressramte elever fra andre elever, hvordan et stressreduktionskurset Åben og Rolig for Unge virker for de unge i gymnasiet, og hvad der...... kan modvirke stress i gymnasiet....

  14. Zur Vor- und Entwicklungsgeschichte des Konzepts 'Ökosozialismus'

    DEFF Research Database (Denmark)

    Czeskleba-Dupont, Rolf; Tjaden, Karl Hermann

    2013-01-01

    Ordet 'økosocialisme' bruges først i anden halvdel af det 20.århundrede, men konceptet har en for- og udviklingshistorie igennem de moderne samfundsteorier. Det opstår, når rene socialutopier forlades og, som det sker hos Karl Marx og Friedrich Engels, der indgår en dybere dimension af...

  15. Strammere retningslinjer om transfer pricing

    DEFF Research Database (Denmark)

    Rossing, Christian Plesner

    2015-01-01

    Transfer pricing vedrører prisfastsættelsen på transaktioner, der foregår mellem koncernforbundne selskaber og er fortsat et tema, der nyder stort fokus hos både multinationale koncerner og skattemyndigheder. For den multinationale koncern er transfer pricing i høj grad en aktivitet, der består i...

  16. Tuberkulose forårsaget af Mycobacterium africanum

    DEFF Research Database (Denmark)

    Bek, Dorte; Kjeldsen, Marianne Kirstine; Hansen, Nikolaj Friis

    2010-01-01

    Tuberkulose (TB) forårsages af patogene arter fra Mycobacterium tuberculosis komplekset (MTBC) og har en incidens på cirka 7/100.000 i Danmark. På mistanke om TB hos en akut indlagt 40 årig afrikansk mand initieredes anti-TB behandling. Efter 13 timers indlæggelse afgik patienten ved døden. Fra...

  17. Dette er ikke for enhver fisk

    DEFF Research Database (Denmark)

    Opstrup, Kasper

    2018-01-01

    Omhandler fremkomsten af moderne okkultisme hos 1800-tallets utopiske socialister der ønskede at skabe en ny religion som grundstenen for en ny religion og denne tankes udvikling fra Eliphas Lévi til Fin-de-Siécle symbolisterne som f.eks. Josephin Péladan, der så kunsten som værende denne religio...

  18. Introduktion om samfundsvidenskabelig sygdomsforskning

    DEFF Research Database (Denmark)

    Gannik, Dorte Effersøe

    1996-01-01

    praktikker, der skaber den menneskelige krop og dermed også former udviklingen og oplevelsen af sygdom hos den enkelte. Sundhedsvæsenet udgør en del af dette perspektiv, og NSS arbejder derfor også for at fremme forskning i sundhedsvæsenets funktion og samfundsmæssige betydning. Praktiserende læger indbydes...

  19. Ånd over ånder

    DEFF Research Database (Denmark)

    Bach-Nielsen, Carsten

    2014-01-01

    Er de døde til stede hos de levende som ånder? Principielt er den kristne lære afvisende over for denne tanke, men i den folkelige tro er det mere den umiddelbare tilstedeværelse af de døde, der er vigtigere end det lange perspektiv: kødets opstandelse....

  20. En bid af ældres hverdagsliv

    DEFF Research Database (Denmark)

    Bundgaard, Karen Marie; Top Christensen, Boye

    2000-01-01

    Undersøgelsen har udforsket hjemmeboende ældres egen forståelse og oplevelse af måltiddsaktiviteters betydning, og hvilke behov aktiviteterne dækker hos de ældre. Aktiviteterne har betydninger der knytter sig til maden men aktiviteterne har også betydninger i sig selv. Undersøgelsen er en af fler...

  1. Er du klar på pizza og spil i aften?

    DEFF Research Database (Denmark)

    Nielsen, Ditte Lundsgaard

    2017-01-01

    I denne artikel kigger vi lidt nærmere på, hvilke erfaringer, der er opstået hos lærerne og pædagogerne. vi tager udgangspunkt i tre forskellige visuelle formidlingsmetoder: tegneserie, infographics og grafisk facilitering. Kunne denne legen med ord og billeder i sproget i børne- og ungekulturen ...

  2. Lektoranmodning for Karen Løth Sass, DMJX

    DEFF Research Database (Denmark)

    Sass, Karen

    2018-01-01

    Det gennemgående tema i min anmodning er forholdet og balancen mellem den induktive/deduktive tilgang i praksislæringen. Titlen på lektoranmodningen er min egen kække sloganisering over den tilgang jeg kan iagttage hos mig selv og medundervisere, når vi næsten undskyldende lover de studerende, at...

  3. Quality Control of traffic models

    DEFF Research Database (Denmark)

    Nielsen, Otto Anker; Hansen, Christian Overgaard

    Kvalitetssikring af trafikmodeller er i de senere år kommet mere og mere i fokus hos både tekni-kere, fagfolk og politikere. Dette har bl.a. givet sig udslag i diskussioner ved faglige arrangemen-ter og i fagtidsskrifter. Der savnes imidlertid i dag et bud på et arbejds-redskab til kvalitets-sikr...

  4. Evaluering af tre projekter i Socialstyrelsens Forældreprogram - Resultatresumé

    DEFF Research Database (Denmark)

    Andersen, Luna Kragh; Scavenius Sonne-Schmidt, Christoffer

    2018-01-01

    ADHD og ADHD-lignende udfordringer er nogle af de mest udbredte former for psykiske proble-mer hos børn og unge (Dick & Ferguson, 2015). Forskning finder, at diagnosen kan stilles hos mindst 5 pct. af en børneårgang, hvilket svarer til 1-2 børn i hver skoleklasse (Polanczyk m.fl., 2007, 2014......; Thomas m.fl., 2015; Willcutt, 2012). Samtidig er ADHD og ADHD-lignende udfordrin-ger forbundet med negative konsekvenser, som har både en personlig pris og en samfundsmæs-sig pris, som fx behov for ekstra støtte i skolen eller særlige skoletilbud, forøget brug af sundhedsydelser og sociale ydelser og...... arbejdsmarkedet, et problempræget forhold til egne børn samt angst, depression og tidlig død (Loeber & Burke, 2011; Skogen & Torvik, 2013). I dag betragtes ADHD som en langvarig eller kronisk sygdom, men mestringsfremmende indsatser kan hjælpe forældre, børn og unge til bedre at håndtere symptomer på ADHD samt...

  5. Positiv Psykiatri

    DEFF Research Database (Denmark)

    Timmerby, Nina; Austin, Stephen F.; Bech, Per

    2016-01-01

    Positiv psykiatri (PP) kan beskrives som en gren inden for psykiatrien, hvor man i særlig grad interesserer sig for at fremme livskvalitet hos mennesker, der allerede har eller er i høj risiko for at få psykisk eller fysisk sygdom [1]. Denne artikel har til formål at give en introduktion til dette...... relativt nye begreb. PP er et forsøg på at udvide den gængse opfattelse af psykiatriens genstandsfelt fra primært at fokusere på bl.a. diagnostik og behandling af symptomer til også at have som mål aktivt at fremme livskvalitet hos målgruppen. Man kan sige, at man inden for PP generelt interesserer sig...... for områder af behandlingen, der kan genoprette patientens livskvalitet, men uden at selve sygdommen nødvendigvis udryddes. Hovedfokus for PP ligger dermed i naturlig forlængelse af WHO’s definition af mental sundhed, hvor sundhed ikke alene er afgjort ved fravær af sygdom, men også ved tilstedeværelsen af...

  6. An investigation of the initial attachment and orientation of osteoblast-like cells on laser grooved Ti-6Al-4V surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Chen, J., E-mail: jianboc@Princeton.EDU [Princeton Institute of Science and Technology of Materials, Princeton University, Princeton, NJ 08544 (United States); Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544 (United States); Ulerich, J.P. [Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544 (United States); Abelev, E. [Department of Chemistry, Princeton University, Princeton, NJ 08544 (United States); Fasasi, A. [Princeton Institute of Science and Technology of Materials, Princeton University, Princeton, NJ 08544 (United States); Center for Energy Research, Obafemi Awolowo University, Ile-Ife (Nigeria); Arnold, C.B.; Soboyejo, W.O. [Princeton Institute of Science and Technology of Materials, Princeton University, Princeton, NJ 08544 (United States); Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544 (United States)

    2009-05-05

    This paper presents the results of an experimental study of the initial cell spreading and adhesion on longitudinally- and transversally-oriented micro-grooves produced by the laser irradiation of laser grooved Ti-6Al-4V surfaces. The initial spreading and orientations of human osteosarcoma (HOS) cells were observed and quantified after 15-min, 1-hour, 4-hour and 24-hour cell culture periods. Immuno-fluorescence staining of adhesion proteins (actin and vinculin) was then used to study the spreading and adhesion of HOS cells in 1 hour and 4 hour culture experiments. The initial cell adhesion was also quantified using enzymatic detachment tests. The results showed that cell spreading and adhesion were enhanced by longitudinally- and transversally-oriented micro-grooves. The effects, which increase with time, were not remarkable after 1 hour, but obvious after 4 hours. Contact guidance was found to promote cell adhesion due to the increase in interactions between the focal adhesions and the patterned extra-cellular matrix (ECM) proteins on the laser micro-grooved surfaces.

  7. An investigation of the initial attachment and orientation of osteoblast-like cells on laser grooved Ti-6Al-4V surfaces

    International Nuclear Information System (INIS)

    Chen, J.; Ulerich, J.P.; Abelev, E.; Fasasi, A.; Arnold, C.B.; Soboyejo, W.O.

    2009-01-01

    This paper presents the results of an experimental study of the initial cell spreading and adhesion on longitudinally- and transversally-oriented micro-grooves produced by the laser irradiation of laser grooved Ti-6Al-4V surfaces. The initial spreading and orientations of human osteosarcoma (HOS) cells were observed and quantified after 15-min, 1-hour, 4-hour and 24-hour cell culture periods. Immuno-fluorescence staining of adhesion proteins (actin and vinculin) was then used to study the spreading and adhesion of HOS cells in 1 hour and 4 hour culture experiments. The initial cell adhesion was also quantified using enzymatic detachment tests. The results showed that cell spreading and adhesion were enhanced by longitudinally- and transversally-oriented micro-grooves. The effects, which increase with time, were not remarkable after 1 hour, but obvious after 4 hours. Contact guidance was found to promote cell adhesion due to the increase in interactions between the focal adhesions and the patterned extra-cellular matrix (ECM) proteins on the laser micro-grooved surfaces.

  8. Om Hegels opfattelse af Gorgias, set på baggrund af tidligere filosofihistorikeres fremstilling

    DEFF Research Database (Denmark)

    Huggler, Jørgen

    2010-01-01

    En undersøgelse af Hegels tolkning af sofisten Gorgias giver anledning til at se på receptionen af sofisterne hos notable filosofihistorikere i det 18. århundrede. En sådan undersøgelse viser, at Hegel har en original og velvillig tolkning af sofisterne koncentreret omkring begrebet Bildung og det...... at give grunde for noget. Hegels udlægning af Gorgias bygger på hans tolkning af eleaterne, især af Zenon. Når Hegel har en særlig tolkning af eleaterne, skyldes det hans egne mangeårige filosofiske bestræbelser, og en identificering af en særlig, immanent objektiv dialektik hos Zenon, som han finder......, at Gorgias fører videre. Hegels filosofiske forståelse er tilstrækkelig udviklet til at kunne knytte positive kommentarer til alle dele af diskussionen i Gorgias' ræsonnement Om det ikkeværende, eller Om naturen. Det lykkes dog bedst i forhold til de to første af Gorgias' tre underteser. I hegelsk perspektiv...

  9. Flight Test of the F/A-18 Active Aeroelastic Wing Airplane

    Science.gov (United States)

    Voracek, David

    2007-01-01

    A viewgraph presentation of flight tests performed on the F/A active aeroelastic wing airplane is shown. The topics include: 1) F/A-18 AAW Airplane; 2) F/A-18 AAW Control Surfaces; 3) Flight Test Background; 4) Roll Control Effectiveness Regions; 5) AAW Design Test Points; 6) AAW Phase I Test Maneuvers; 7) OBES Pitch Doublets; 8) OBES Roll Doublets; 9) AAW Aileron Flexibility; 10) Phase I - Lessons Learned; 11) Control Law Development and Verification & Validation Testing; 12) AAW Phase II RFCS Envelopes; 13) AAW 1-g Phase II Flight Test; 14) Region I - Subsonic 1-g Rolls; 15) Region I - Subsonic 1-g 360 Roll; 16) Region II - Supersonic 1-g Rolls; 17) Region II - Supersonic 1-g 360 Roll; 18) Region III - Subsonic 1-g Rolls; 19) Roll Axis HOS/LOS Comparison Region II - Supersonic (open-loop); 20) Roll Axis HOS/LOS Comparison Region II - Supersonic (closed-loop); 21) AAW Phase II Elevated-g Flight Test; 22) Region I - Subsonic 4-g RPO; and 23) Phase II - Lessons Learned

  10. Når almenpædagogikken bliver den bedste forbyggelse af angst

    DEFF Research Database (Denmark)

    Hviid, Pernille; Esbjørn, Barbara Hoff; Villadsen, Jakob Waag

    2018-01-01

    Formålet med artiklen er at invitere til dialog mellem børneklinisk, almen udviklingspsykologisk og almen pædagogisk praksis med henblik på forebyggelse af angst hos børn. Artiklen forsøger at begrebsliggøre og videreudvikle kvaliteter ved den almene pædagogiske praksis i relation til børneklinis...

  11. Resten i Vesten

    DEFF Research Database (Denmark)

    Moberg, Bergur Rønne

    kontekst med kraftlinjer mellem kontinentale romanklassikere af Thomas Mann og Albert Camus og Atlanterhavserfaringer hos fire færøske romanforfattere: William Heinesen, Jørgen-Frantz Jacobsen, Jens Pauli Heinesen og Gunnar Hoydal. Vægten er lagt på færøsk litteratur, der har skabt en række værker af...

  12. Multiple perspectives on symptom interpretation in primary care research

    DEFF Research Database (Denmark)

    Rosendal, Marianne; Jarbøl, Dorte Ejg; Pedersen, Anette Fischer

    2013-01-01

    Vurdering af symptomer er en af de vigtigste opgaver i den primære sundhedssektor. Symptomer beskrives ofte som noget absolut, men hos både læge og patient er symptomer resultatet af en fortolkningsproces, som påvirkes af en række forhold. Denne artikel ser nærmere på, hvordan symptomer fortolkes...

  13. Muskel-skeletbesvær i tandplejen: Prævalens, forebyggelse og rehabilitering

    DEFF Research Database (Denmark)

    Fredslund, Gitte Hansen; Sjøgaard, Gisela

    2017-01-01

    Introduktion: Prævalensen af muskel-skeletbesvær (MSB) i lænd, nakke, skuldre og underarme/hænder er meget høj hos tandlæger, klinikassistenter og tandplejere. Dette kan skyldes ensidigt gentaget arbejde og meget fastlåste arbejdsstillinger. Formål: At give et indblik i hvilke jobsituationer der ...

  14. Cancer Mortality in People Treated with Antidepressants before Cancer Diagnosis

    DEFF Research Database (Denmark)

    Sun, Yuelian; Vedsted, Peter; Fenger-Grøn, Morten

    2015-01-01

    Depression forekommer ofte efter en kræftdiagnose og forbindes med øget mortalitet. Det er dog uvist, om depression i perioden før en kræftdiagnose også påvirker mortaliteten. Dette studie undersøger mortaliteten hos patienter, som blev behandlet med antidepressiv medicin før en kræftdiagnose...

  15. Brasilien bygger sit eget internet

    DEFF Research Database (Denmark)

    Hansen, Kenneth; Føhns, Henrik

    2014-01-01

    Den brasilianske præsident Dilma Rousseff har sat blus under landets planer om at lave et internet, der ikke løber gennem USA, og hvor brasilianske borgeres data bliver på servere i Brasilien – også selvom de ligger hos Google eller Facebook. Hun vil også have det nationale postvæsen til at tilbyde...

  16. Veterinær paternalisme

    DEFF Research Database (Denmark)

    Sandøe, Peter

    2016-01-01

    Respekt for klientens selvbestemmelse står højt i kurs hos den veterinære profession i USA og England. I kontrast hertil synes mange danske dyrlæger at lægge vægt på at vise omsorg over for svage klienter. Hermed er der lagt op til en etisk diskussion....

  17. Velkommen til Merkolland

    DEFF Research Database (Denmark)

    Just, Sine Nørholm

    2012-01-01

    Francois Hollandes første officielle handling som Frankrigs præsident var at tage på besøg hos den tyske kansler Angela Merkel. Dermed signalerede Hollande klart, at selvom han i den franske valgkamp slog til lyd for en genforhandling af EU’s finanspagt, så ved han godt, at vejen til EU...

  18. Fra Jersore til Kina

    DEFF Research Database (Denmark)

    Littrup, Leif

    2009-01-01

    Kronik om Maren Kirstine Rasmussen (1893-1937), der var opvokset i Jersore og senere udvandret til USA. Fra 1923 til sin død var hun missionær i Sydkina, udsendt af Aggregation of God (Pinsebevægelsen). Om den Stambog og andet materiale, der er efterladt hos familien i Danmark. [I alt ca. 8...

  19. Mikrobiologer ser bakterier i kortene

    DEFF Research Database (Denmark)

    Harmsen, Morten; Sternberg, Claus; Haagensen, Janus Anders Juul

    2008-01-01

    at klumpe sig sammen i slimede biofilm, som især er et stort problem på hospitalerne og hos patienter med kroniske infektioner. For at kunne bekæmpe biofi lm må forskerne vide mere om, hvorfor og hvordan filmen dannes. Ny viden inden for mikrobiologien og udviklingen af nanoteknologiske mikroskoper hjælper...

  20. The implications of a "decontextualised" and a "contextualised" view of learning how to practice nursing

    DEFF Research Database (Denmark)

    Glinsvad, Birte

    Eksempel på hvordan to forskellige forståelser af læring, - læring som betinget af undervisning og læring som værende en del af et praksisfællesskab, - sætter sig igennem hos henholdsvis Bjerknes m.fl. (1988) i deres anbefalinger for tilrettelæggelse af praktikuddannelse for sygeplejestuderende, ...

  1. Projekt READ - sammen om læsning

    DEFF Research Database (Denmark)

    Christensen, Mette Vedsgaard; Østerbye, Torkil

    2015-01-01

    Projekt READ er et et-årigt projekt gennemført i et samarbejde mellem TrygFondens Børneforskningscenter, Aarhus Universitet, Aarhus Kommune og VIA University College. Projektet undersøger, om læse- og skrivefærdigheder hos elever i 2. og 3. klasse kan løftes gennem en intervention, hvor forældre...

  2. Implementering af accountability - en udfordring for den pædagogiske profession

    DEFF Research Database (Denmark)

    Mørk, Brian

    2014-01-01

    dagtilbudområdet på. En styring, der kan identificeres som en accountability-politik, hvor det pædagogiske personale ansvarliggøres og stilles til regnskab for deres præstationer i arbejdet med udsatte børn. Fokus rettes blandt andet på de vanskeligheder og konsekvenser, der opstår hos ”gulvpædagoger” i...

  3. Reformationens tøvende omfortolkning af kætterbegrebet

    DEFF Research Database (Denmark)

    Holm, Bo Kristian; Thomsen, Søren Feldtfos

    2012-01-01

    Denne artikel undersøger påstanden om en omfortolkning af kætterbegrebet i den lutherske reformation. Der argumenteres for, at det giver god mening at tale om nytænkning af kætterbegrebet hos den unge Luther i form af en internalisering af kætteriet, hvor den enkeltes eget syndige selv udpeges som...

  4. Forvandling, fortælling og handling med mening

    DEFF Research Database (Denmark)

    Dupont, Søren

    2015-01-01

    Artiklen fokuserer på en række begreber og udviklinger hos Jerome Bruner og diskuterer de forskellige grundlag, som Jerome Bruner gennem tiderne har haft fokus på uden at noget grundlag på noget tidspunkt entydigt har været bestemmende. Jerome Bruner har bevæget sig fra at være orienteret mod...

  5. Midlertidighedens paradokser og rationaler

    DEFF Research Database (Denmark)

    Kiib, Hans

    2016-01-01

    metoder, der har til formål at fremme en social bevidsthed om at tingene kunne være anderledes og styrke et lokalt beredskab i forhold at kunne handle herpå. I dag oplever vi, at disse metoder i stadig stigende omfang operationaliseres og implementeres i planlægningen i kommuner og hos private investorer...

  6. Calmettevaccinen tages i brug igen

    DEFF Research Database (Denmark)

    Thybo Pihl, Gitte; Stensballe, Lone Graff; Ammentorp, Jette

    2013-01-01

    Conflict Scale” og bygger bl.a. på spørgeskemainterview. Historier om enkelte uheldige tilfælde og symptomer, som kædes sammen med en vaccination, kan meget let give usikkerhed og bekymring hos dem, der skal tage stilling til, om deres barn skal vaccineres. Det er derfor vigtigt at undersøge, hvad der...

  7. Fiberarmerede, cementbaserede kompositmaterialers levetid

    DEFF Research Database (Denmark)

    Stoklund Larsen, E.

    I denne SBI-rapport gennemgås en række forhold af betydning for fiberarmerede, cementbundne kompositmaterialers levetid, og der vises resultater fra en række langtidsforsøg gennemført hos SBI. - Endelig gennemgås den væsentligste inden- og udenlandske litteratur på området, og der afsluttes med e...

  8. Om den sociale og symbolske funktion af uddannelsesevalueringer

    DEFF Research Database (Denmark)

    Nørholm, Morten

    Afhandlingens teoretiske udgangspunkt er hos Émile Durkheim, Pierre Bourdieu, Ulf P. Lund­gren, Staf Callewaert, det konkrete er en række evalueringer af uddannelser til (semi)professioner inden for sundhedssektoren.                I afhandlingen konstrueres den sociale og symbolske funktion af...

  9. En klassiker - død eller levende?

    DEFF Research Database (Denmark)

    Bruun, Hans Henrik

    2003-01-01

    række centrale begreber og teser hos Max Weber fører til den konklusion, at de i dag i betydeligt omfang har tabt deres relevans. Men Weber forbliver central også for den moderne sociologi, fordi hans tilgang konsekvent reflekterer den grundlæggende spænding mellem vilje og nødvendighed, og fordi den...

  10. Regninput til regnvandsdisponering i Aarhus Vands forsyningsområde

    DEFF Research Database (Denmark)

    Thorndahl, Søren Liedtke

    Dette tekniske memorandum er udarbejdet at Søren Thorndahl, Aalborg Universitet til brug i den Regnvandsdisponeringsplanlægning som pågår hos Aarhus Vand i efteråret 2017. Arbejdet er udført som en del af udviklingsprojektet KLIMAKS - Klimafremskrivning af målt nedbør til afløbsteknisk anvendelse...

  11. Achenbachs child behavior checklist CBCL og relaterede instrumenter

    DEFF Research Database (Denmark)

    Nissen, Poul Erik

    Achenbachs empiribaserede assessmentsystem (ASEBA) består af en række spørgeskemaer, som er udviklede med henblik på vurdering af et bredt spektrum af problemfelter og kompetencer hos børn, unge og voksne lige fra 1½ års alderen til 90+.Det er et såkaldt multiinformant system, hvor hovedparten af...

  12. The effects of food and maternal conditions in fetal growth and size in wild reindeer

    Directory of Open Access Journals (Sweden)

    Terje Skogland

    1984-05-01

    Full Text Available Fetal growth rates and birth weights were studied in four wild reindeer areas in Southern Norway (Hardangervidda, Hallingskarvet, Knutshø, Forelhogna, representing high and low density populations, with a 5-fold difference in mean lichen winter-food availability. Fetal growth was depressed by 42% in the high-densitv Hardangervidda population, and mean birth weights were 3.7 vs. 6.2 kg, with a 10 days difference in mean birth dates. Fetal size was better correlated with maternal weight, than age. Maternal weights increased until 5 yrs. of age and then decreased in the high-density Hardangervidda population (but not so in the low density Knutshø-Forclhogna populations. 55% of the offspring died before weaning in the Hardangervidda herd, but no significant calf losses were found amont the large-sized does in the food-abundant areas.Effekter av ernæring og simlas kondisjon på vekst og størrelse av foster hos villrein.Abstract in Norwegian / Sammendrag: Fostervekst og fødselsvekter ble undersøkt i fire villreinområder i Sør-Norge (Hardangervidda, Hallingskarvet, Knutshø og Forelhogna som representerer høg- og lågtetthetsstammer, med en 5-foldig forskjell i gjennomsnittlig lavbeite-tilgang om vinteren. Fosterveksten ble nedsatt med 42% i høgtetthetsstammen på Hardangervidda og fødselsvektene var i gjennomsnitt 3,7 kg, mot 6,2 kg i det beste området, og med en 10 dagers forsinkelse i midlere fødselsdato. Fosterets størrelse var korrelert med morens vekt, som igjen var avhengig av hennes alder. Hos de minste simlene i det dårligste området økte vektene til 5-års alder, for deretter å avta for hvert gjenlevende år. Hos simlene i det beste området økte vektene til 10-års alder, og var da dobbelt så tunge som fra det dårligste området. 55% av avkommet døde før de var avvent med diing hos Hardangervidda-simlene, mens det ikke var noen statistisk målbar dødelighet hos kalvene i Knutshø-Forelhogna.Ravinnon vaikutus ja

  13. Mangler - ressourcer - erfaring

    DEFF Research Database (Denmark)

    Pedersen, Michael Svendsen

    2008-01-01

    Stort frafald og lavt niveau hos etniske minoritetselever i erhvervsuddannelserne er problemer som forsøges løst gennem en lang række pædagogiske udviklingsprojekter. Der udvises både kreativitet og engagement i bestræbelserne på at finde "værktøjer" der kan hjælpe eleverne til at forblive i og g...

  14. Hvordan føles det at tabe i OECD?

    DEFF Research Database (Denmark)

    Staunæs, Dorthe; Pors, Justine Grønbæk

    2011-01-01

    Når OEDC rapporter sammenligner skolesystemer på tværs af nationale grænser, aktiveres følelsesregisteret hos såvel politikere som forskere. I Danmark og en række andre Europæiske lande er det særligt bekymringer og følelser som skuffelse, frygt for den Østasiatiske tiger og skam på nationens vegne...

  15. Kun 2 måneder tilbage – fondes krav mod SKAT for manglende fradrag for uddelinger til modtagere i udlandet skal rejses inden 1. januar 2018

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2017-01-01

    En fond kan have penge til gode hos SKAT, når en fond i fortiden, helt tilbage til indkomståret 2004, ikke har fået fradrag til uddelinger til almindelige (ikke-almennyttige) modtager med bopæl i udlandet. Men kravet skal rejses over for SKAT inden den 1. januar 2018. Kravet er den skat, som fonden...

  16. Fusa arium branch h bligh Arg ht on h gentin highbu na sh blu ...

    African Journals Online (AJOL)

    SAM

    2008-12-07

    Dec 7, 2008 ... C. maxima D max (L.) Mer. Pinus elliottii and P. Laws orded as hos. Huespe et a ntry near veg usceptible to this new ho. In addition, een reported carrots ... Amaranthu ss.) Hanelt l., Cucurbita. Lam. subsp m distichon L nus ponderosa s taeda L. are cuminatum in s blueberry is al and oil crop um as cited in.

  17. A comparative study of two fast nonlinear free-surface water wave models

    DEFF Research Database (Denmark)

    Ducrozet, Guillaume; Bingham, Harry B.; Engsig-Karup, Allan Peter

    2012-01-01

    simply directly solves the three-dimensional problem. Both models have been well validated on standard test cases and shown to exhibit attractive convergence properties and an optimal scaling of the computational effort with increasing problem size. These two models are compared for solution of a typical...... used in OceanWave3D, the closer the results come to the HOS model....

  18. Retfærdiggørelse, ideologi, kritik

    DEFF Research Database (Denmark)

    Albertsen, Niels

    2008-01-01

    Denne artikel har tre formål. For det første er det hensigten at udrede forbindelserne mellem begreberne retfærdiggørelse, ideologi og kritik, som de foreligger hos Luc Boltanski og Ève Chiapello i Le nouvel esprit du capitalisme  (1999) (NEC i det følgende) og denne bogs forudsætninger. For det...

  19. The significance of comorbid physical conditions on the excess mortality of persons with severe mental illness

    DEFF Research Database (Denmark)

    Ribe, Anette Riisgaard

    Diabetes, brystkræft og infektion kan medvirke til, at personer med svære psykiatriske lidelser i gennemsnit dør 15-20 år før andre. Det er konklusionen i en ny ph.d.-afhandling fra Aarhus Universitet. Overdødeligheden hos mennesker med svære psykiatriske lidelser kan være forbundet med en højere...

  20. Familiepleje i Danmark

    DEFF Research Database (Denmark)

    Bryderup, Inge; Engen, Mie; Kring, Sune

    Familiepleje i Danmark handler om den danske familiepleje – om de familier, som vælger at blive familieplejere, og om de børn og unge, der er anbragt hos dem. Siden slutningen af 1980’erne har familiepleje været den mest anvendte anbringelsesform, når det gælder socialt udsatte børn og unge. Vi v...

  1. Fire måder at håndtere åndenød på i dagliglivet: et grounded theory studie

    DEFF Research Database (Denmark)

    Bastrup, Lene; Dahl, Ronald; Pedersen, Preben Ulrich

    2013-01-01

    , primært håndterer deres åndenød i dagligdagen. Vi valgte et multimodalt "grounded theory"-design, der gør det muligt at kombinere kvalitative og kvantitative data med henblik på at indfange og forklare den flerdimensionelle håndteringsadfærd hos mennesker med KOL. I håndtering af åndenøden var patienterne...

  2. De internationale markeder for dansk svinekød

    DEFF Research Database (Denmark)

    Nielsen, Niels Asger

    2005-01-01

    En af de parametre, som har størst betydning for, om efterspørgselen efter dansk svinekød kan opretholdes eller øges i de kommende år er, hvordan ønsker og behov hos de endelige forbrugere udvikler sig i fremtiden. Det kan vi af gode grunde ikke vide præcist, men vi kan med udgangspunkt i blandt ...

  3. Fremtidens Biodiesel: Kom fedtaffald i tanken!

    DEFF Research Database (Denmark)

    Madsen, Anders Theilgaard; Taarning, Esben; Christensen, Claus Hviid

    2009-01-01

    Mange tror måske, at det er svært for menigmand at lave biobrændstof. Det er faktisk forkert, fordi biodiesel nemt kan laves af kemikalier, der er ret almindelige i laboratorier og hos købmanden og materialisten. Det kræver blot en såkaldt om-estring af planteolie eller fedt med methanol, samt...

  4. Retfærdiggørelse, ideologi, kritik

    DEFF Research Database (Denmark)

    Albertsen, Niels

    2008-01-01

    Denne artikel har tre formål. For det første er det hensigten at udrede forbindelserne mellem begreberne retfærdiggørelse, ideologi og kritik, som de foreligger hos Luc Boltanski og Ève Chiapello i Le nouvel esprit du capitalisme  (1999) (NEC i det følgende) og denne bogs forudsætninger. For det ...

  5. Ih, hvor jeg dog savner dig...!

    DEFF Research Database (Denmark)

    Nielsen, Anne Maj

    2008-01-01

    Artiklen debatterer forholdet mellem børns behov for kontakt med forældre og forældres behov for bekræftelse af ders identitet som forældre og kontrol med deres børn, når de ikke er hjemme men fx på koloni eller hos 'den anden' forælder, når disse er skilt....

  6. GRO modellen

    DEFF Research Database (Denmark)

    Otto, Lars

    Working Paperet indeholder overvejelser om en stokastisk model g dens brug til at beskrive økonomiske konsekvenser af forskellige behanslings- og kontrolstrategier ved mave-tarm og luftvejslidelser hos fravænnede grise og slagtesvin. Der er en beskrivelse af modellens struktur, data og brug. Mode....... Modellen er udarbejdet som led i CEPROS' forskningsprojekt "Decision support systemfor animal healt and economics within pig production"....

  7. Er der sammenhæng mellem foderudnyttelse, aktivitet og sundhed?

    DEFF Research Database (Denmark)

    Damgaard, Birthe Marie; Hansen, Steffen W

    2010-01-01

    Gennem de senere år er minken blevet tungere år efter år, og undersøgelser har vist, at det er muligt at øge foderudnyttelsen gennem avl. Formålet med denne undersøgelse var at belyse aktivitet, kropsvægt og immunstatus hos mink med høj og lav residual foderindtag (RFI) ved restriktiv og ad libit...

  8. Assessment of the structure of pegylated-recombinant protein therapeutics by the NMR fingerprint assay.

    Science.gov (United States)

    Hodgson, Derek J; Aubin, Yves

    2017-05-10

    A number of recombinant protein therapeutic products, such as filgrastim (methionyl granulocyte colony stimulating factor [Met-GCSF] used to boost the immune system in chemotherapy treated cancer patients), and interferon alpha-2 (used for the treatment of various viral infections), have been chemically modified with the addition of a polyethylene glycol (PEG) chain. This modification prolongs residency of the drug in the body and reduces metabolic degradation, which allows less frequent administration of the products. Here we show how NMR spectroscopy methods can assess the higher order structure (HOS) of pegylated-filgrastim (Neulasta®), pegylated interferon-α2a (Pegasys®) pegylated interferon-α2b (PEG-Intron®) purchased from the marketplace. The addition of the PEG moiety effectively doubles the molecular weight of the three products. This presents a significant challenge for the application of NMR techniques. Nevertheless, the results showed that high-resolution spectra could be recorded for two of the three products. Comparison of the spectra of the pegylated protein and the non-pegylated protein shows that the chemical modification did not alter the HOS of these proteins. Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.

  9. On the quality of Svalbard reindeer pasture in the summer and autumn

    Directory of Open Access Journals (Sweden)

    Hans Staaland

    1984-05-01

    Full Text Available Late summer and autumn reindeer pasture plants from Adventdalen, Svalbard were analyzed for contents of fatty acids, energy content, protein, fibre, ether extract as well as content of macro minerals. Food intake of grazing reindeer in Adventdalen was estimated from fecal production. Large intake of high quality food seems to account for the growth and fattening of Svalbard reindeer during summer.Om kvaliteten på reinbeite av reinbeite på Svalbard sommer og høst.Abstract in Norwegian / Sammendrag: Innholdet av fettsyrer, energi, protein, fiber, eterekstrakt og makromineraler ble analysert i reinbeiteplanter fra Adventdalen på Svalbard. Plantene ble samlet på ettersommeren. Forinntaket hos beitende rein i Adventdalen ble estimert ut fra fecesproduksjonen. Et stort inntak av for med høy kvalitet synes å kunne forklare vekst og fettlagring hos Svalbard-reinen om sommeren.Huippuvuorten poronlaidunten laadusta kesalla ja syksylla.Abstract in Finnish / Yhteenveto: Rasvahappojen, energian, fiiberin, eetteriuutteen ja makromineraalien sisaltoa analysoitiin poronlaidunkasveissa Huippuvuorten Adventtilaaksosta. Kasvit kerattiin loppukesalla. Adventtilaaksossa laiduntavien porojen rehun kulunki arvioitiin lannan maarasta. Korkealaatuisen rehun suuri kulutus nayttaa vovan selittaa Huippuvuorten porojen kasvun ja rasvakerrostuman kesalla.

  10. Growth rates and morphological measurements of Porcupine caribou calves

    Directory of Open Access Journals (Sweden)

    Katherine L. Parker

    1989-06-01

    Full Text Available Body weights, leg lengths, and surface area were monitored for bottle-raised barren-ground caribou calves (Rangifer tarandus granti from the Porcupine herd up to 1 year of age. Body weights were compared with maternally-raised calves from the same cohort in the wild and from the Delta herd. A successful feeding regime for bottle-raising caribou calves is presented.Veksthastigheter og morfologiske mål hos Porcupine karibu-kalver.Abstract in Norwegian / Sammendrag: Kroppsvekter, visse knokkel-lengder og kropps-overflate areal ble målt hos flaske-oppfødde kalver av barren-ground karibu (Rangifer tarandus granti fra Porcupine-stammen opp til 1 års alder. Kroppsvekter ble sammelignet med normalt oppfødde kalver av samme type i det fri og fra Delta-stam-men. Det presenteres et vellykket system for flaske-oppforing av karibu-kalver.Porcupine-lauman karibuvasojen kasvunopeus ja morfologiset mitat.Abstract in Finnish / Yhteenveto: Porcupine -lauman pulloruokinnalla olleiden tundrakaribuvasojen ruumiinpainot, jalanpituu-det ja ruumiin pinta-alat mitattiin 1 vuoden ikäään saakka. Ruumiinpainoja verrattiin vastaaviin luonnon-oloissa kasvaneisiin saman lauman ja Delta -lauman vasoihin. Tutkimus kuvaa toimivan vasojen pulloruo-kintamenetelmän.

  11. Collective bargaining on wages in Denmark

    DEFF Research Database (Denmark)

    Andersen, Søren Kaj; Navrbjerg, Steen Erik

    2008-01-01

    17 kapitler kommer på forskellig vis rundt om disse hovedstrømninger, men indeholder naturligvis også mange andre informationer om lønfastsættelse på det europæiske arbejdsmarked. Bogen kan købes hos ETUI i Bruxelles bl.a. via deres hjemmeside: http://www.etui-rehs.org/research/activities/Workers-representation/Books/Wages-and-wage-bargaining-in-Europe...

  12. Shared care in prostate cancer

    DEFF Research Database (Denmark)

    Lund, Anette Svarre; Lund, Lars; Jønler, Morten

    2016-01-01

    Cirka 20 % af de patienter, der går til kontrol i urologiske ambulatorier efter afsluttet behandling for prostatakræft, ønsker at bliver fulgt hos egen læge. Men følger patienterne så planen? Og er kvaliteten af opfølgningen i orden − eller falder de mellem de berømte to stole? Dette studie følge...

  13. Long-term risk of atrial fibrillation after the death of a partner

    DEFF Research Database (Denmark)

    Graff, Simon; Fenger-Grøn, Morten; Christensen, Bo

    2016-01-01

    Dette studie viser, at mennesker, som for nylig har mistet deres partner, har en øget risiko for at udvikle uregelmæssig hjerterytme i op til ét år efter tabet. Den øgede risiko forekommer i op til et år efter tabet, og den største risiko ses hos efterladte på under 60 år og ved uventede dødsfald...

  14. Fra synd til skyld

    DEFF Research Database (Denmark)

    Hansen, Kim Toft

    2009-01-01

    Det er velkendt at sætte skellet hos Edgar Allan Poe, når de første detektivfortællinger skal lokaliseres. Poes tre fortællinger om C. Auguste Dupin fra 1841 til 1844 introducerer den rationelle detektiv for første gang i den vestlige litteratur. Spørgsmålet er bare, om det så derfor betyder, at ...

  15. Relative growth rate of rich fen bryophytes

    DEFF Research Database (Denmark)

    Andersen, Dagmar Kappel; Ejrnæs, Rasmus; Riis, Tenna

    Rigkær er blandt den nordlige halvkugles mest artsrige naturtyper, og en lang række sjældne og truede plantearter er knyttet til netop disse områder. I dette forsøg undersøges den relative vækstrate hos to almindelige og to sjældne rigkærsmosser i relation til forskellige niveauer af næringsstoff...

  16. Predicting effects and risk of relapse into depression: The Danish ECT/MRI project

    DEFF Research Database (Denmark)

    Gbyl, Krzysztof; Rosenberg, Raben; Larsson, Henrik Bo Wiberg

    Formål: Vi ønsker at undersøge hjernen hos patienter med svær depression før og efter elektrokonvulsiv terapi (ECT), samt ved en kontrol efter 6 måneder med det formål at: 1. undersøge hjernevævet så en evt. skadelig effekt af ECT-behandling kan udelukkes 2. belyse mekanismerne bag ECT for at fin...

  17. Administration

    DEFF Research Database (Denmark)

    Bogen handler om den praksis, vi kalder administration. Vi er i den offentlige sektor i Danmark hos kontorfolkene med deres sagsmapper, computere, telefoner,, lovsamlinger,, retningslinier og regneark. I bogen udfoldes en mangfoldighed af konkrete historier om det administrative arbejde fra...... forskellige områder i den offentlige sektor. Hensigten er at forstå den praksis og faglighed der knytter sig til det administrative arbejde...

  18. Risikonavigation i fremdriftsstormen

    DEFF Research Database (Denmark)

    Sarauw, Laura Louise; Madsen, Simon Ryberg

    2017-01-01

    I artiklen bruger vi myten om følgerne af Odysseus’ besøg hos vindenes konge som billede på den med fremdriftsreformen (2014) følgende forestilling om, at det er muligt at sætte en på forhånd fastlagt kurs, hvor blot én vind (et økonomisk rationale) driver de studerende med ét bestemt outcome til...

  19. Use of the smartphone application "Pregnant with Diabetes"

    DEFF Research Database (Denmark)

    Nørgaard, Sidse Kjærhus; Nichum, Vibeke Ladefoged; Barfred, Charlotte

    2017-01-01

    INTRODUCTION: The aim of this article was to evaluate the awareness and use of the smartphone application (app) "Pregnant with Diabetes" locally, nationally and internationally. METHODS: In 2013, a patient initiated collaboration with the staff at Centre for Pregnant Women with Diabetes, Rigs-hos...... by Novo Nordisk, Bayer A/S, Diabetes Care, Abbott, MSD Denmark, A.D.I.P.S and Rigshospitalet. TRIAL REGISTRATION: not relevant....

  20. Cancer cervicis uteri i Århus Amt efter indførelse af screening

    DEFF Research Database (Denmark)

    Nieman, Isa; Lidang, Marianne; Baandrup, Ulrik

    2006-01-01

    diagnosticeret i stadium IA eller IB, og langt hovedparten af disse var under 60 år. De højere stadier (II-IV) sås hyppigst hos kvinder over 60 år. 42 % af ccu-tilfældene blev påvist ved screening. 95 % af kvinderne over 60 år og 46 % af dem under 60 år blev diagnosticeret pga. symptomer. Det hyppigste symptom...

  1. Lourdes

    DEFF Research Database (Denmark)

    Baunvig, Katrine Frøkjær

    2017-01-01

    Denne artikel skitserer fremvæksten af Lourdes som helligsted fra midten til slutningen af 1800-tallet. Denne skitse tegner blandt andet konturerne af processionspraksissers betydning for helligtstedets etablering. Men artiklens egentlige tyngdepunkt er undersøgelsen af processionsskildringerne i...... overraskende slægtskab med den formative religionsvidenskabs interesse for ‘religiøse kræfter’ som den formuleres fx hos Émile Durkheim....

  2. Primær kutan kryptokokkose hos dueavler

    DEFF Research Database (Denmark)

    Andersen, Kjeld; Ravn, Pernille; Bangsborg, Jette Marie

    2011-01-01

    A Danish 73 year-old male patient with polymyalgia rheumatica and in prednisone treatment presented with a cutaneous ulcer on the hand caused by a scratch from a pigeon. Initial treatment with antibiotics was unsuccessful. Biopsy revealed Cryptococcus neoformans and the patient recovered on antif......A Danish 73 year-old male patient with polymyalgia rheumatica and in prednisone treatment presented with a cutaneous ulcer on the hand caused by a scratch from a pigeon. Initial treatment with antibiotics was unsuccessful. Biopsy revealed Cryptococcus neoformans and the patient recovered...

  3. Fod- og ankeltraume hos patient med diabetes

    DEFF Research Database (Denmark)

    Falborg, Bettina; Ebskov, Lars

    2009-01-01

    treatment of sprains and fractures with immobilisation and a non-weight bearing period is significantly prolonged, frequently doubled, in diabetic patients. Follow-up includes frequent ambulatory controls including X-rays. If the neuroarthropathy progresses, the period of treatment is adjusted accordingly.......If confronted with a neuropathic patient with an acute foot-ankle trauma, including fracture, this patient is by definition Eichenholtz stage 0. This is of major importance for the treatment. Whereas the surgical handling of fractures does not differ from ordinary fracture treatment, the subsequent...

  4. Dermatologiske reaktioner hos patienter i antineoplastisk behandling

    DEFF Research Database (Denmark)

    Prasad, Sumangali Chandra; Vestergaard, Hanne; Bygum, Anette

    2014-01-01

    Every year more than 33,000 Danish patients are treated with traditional chemotherapy or targeted therapy against cancer. Cutaneous side effects to these therapies are common and may contribute significantly to the morbidity, but rarely to the mortality of the patients undergoing these treatments....... We present the most classical types of drug rashes associated with antineoplastic therapy. Haematologists, oncologists and dermatologists should be aware of these reactions and early recognition and management is important for providing optimal care....

  5. Melkersson-Rosenthals syndrom hos en ung mand

    DEFF Research Database (Denmark)

    Lauritzen, Elisabeth; Jørkov, Andreas P Schjellerup

    2017-01-01

    A 24-year-old man presented with orofacial swelling, peripheral facial palsy and fissured tongue. Apart from a previous episode of peripheral palsy, he had no history of illness. Biopsy of the lip, blood tests, magnetic resonance imaging of the head and lumbar puncture showed no pathology. He rec...

  6. Syskonplaceringens relation till personligheten hos vuxna personer

    OpenAIRE

    Lindberg, Charlotta

    2015-01-01

    Individers placering i syskonskaran och dess relation till beteenden har varit i fokus för otaliga studier. Det finns dock relativt lite forskning kring syskonplaceringens relation till personlighet i Sverige. Syftet med denna studie var att undersöka syskonplaceringens relation till personligheten enligt Big Five-Inventory (Zakrisson, 2010). Studien inkluderade vuxna personer (N=1070) som var relaterade till Stockholms universitets databas och svarade elektroniskt på enkäten (BFI). Fyra grup...

  7. Periacetabulaer osteotomi og hoftedysplasi hos yngre voksne

    DEFF Research Database (Denmark)

    Troelsen, Anders; Søballe, Kjeld

    2009-01-01

    The periacetabular osteotomy is recognized as the surgical treatment of choice in young adults with symptomatic hip dysplasia. The procedure is performed to delay or prevent the development of osteoarthritis. The procedure has the ability to improve function and preserve hip joints in > 80...

  8. Insekticidresistens hos væggelus i Danmark

    DEFF Research Database (Denmark)

    Kilpinen, Ole; Jensen, Karl-Martin Vagn; Kristensen, Michael

    . Organophosfaten chlorpyrifos, var der derimod kun let nedsat følsomhed for og denne viste sig fuldt effektiv når væggelusene blev eksponeret på overflader behandlet med de kommercielle produkter. Da chlorpyrifos næppe bliver gen-registreret, står man tilbage med pyrethroiderne, som ikke længere kan anbefales til...

  9. HIV hos ældre kvinder efter udlandsrejse

    DEFF Research Database (Denmark)

    Jespersen, Sanne; Thorsteinsson, Kristina; David, Kim Peter

    2016-01-01

    We report two cases of HIV infection among female travellers of older age. A Danish woman in her eighties was diagnosed with acute HIV infection after travelling to West Africa. A sexual history was not recorded before her third hospital visit. A West African woman in her seventies who had been...... living in Denmark for 40 years was diagnosed with advanced HIV after having been to West Africa for family visits. We want to emphasize that women of older age also have sex that may put them at risk of HIV, that febrile returning travellers should be tested for HIV, and that presence of HIV indicator...

  10. Fod- og ankeltraume hos patient med diabetes

    DEFF Research Database (Denmark)

    Falborg, Bettina; Ebskov, Lars

    2009-01-01

    If confronted with a neuropathic patient with an acute foot-ankle trauma, including fracture, this patient is by definition Eichenholtz stage 0. This is of major importance for the treatment. Whereas the surgical handling of fractures does not differ from ordinary fracture treatment, the subsequent...... treatment of sprains and fractures with immobilisation and a non-weight bearing period is significantly prolonged, frequently doubled, in diabetic patients. Follow-up includes frequent ambulatory controls including X-rays. If the neuroarthropathy progresses, the period of treatment is adjusted accordingly...

  11. Fod- og ankeltraume hos patient med diabetes

    DEFF Research Database (Denmark)

    Falborg, Bettina; Ebskov, Lars

    2009-01-01

    If confronted with a neuropathic patient with an acute foot-ankle trauma, including fracture, this patient is by definition Eichenholtz stage 0. This is of major importance for the treatment. Whereas the surgical handling of fractures does not differ from ordinary fracture treatment, the subsequent...... treatment of sprains and fractures with immobilisation and a non-weight bearing period is significantly prolonged, frequently doubled, in diabetic patients. Follow-up includes frequent ambulatory controls including X-rays. If the neuroarthropathy progresses, the period of treatment is adjusted accordingly....

  12. Periacetabulaer osteotomi og hoftedysplasi hos yngre voksne

    DEFF Research Database (Denmark)

    Troelsen, Anders; Søballe, Kjeld

    2009-01-01

    % of cases for more than ten years following surgery. A new minimally invasive technique is safe and reduces blood loss, transfusion requirements and duration of surgery. Overall, the results support the use of periacetabular osteotomy, though further documentation of long-term effects is warranted.......The periacetabular osteotomy is recognized as the surgical treatment of choice in young adults with symptomatic hip dysplasia. The procedure is performed to delay or prevent the development of osteoarthritis. The procedure has the ability to improve function and preserve hip joints in > 80...

  13. Laparoskopisk splenektomi for hereditaer sfaerocytose hos born

    DEFF Research Database (Denmark)

    Petersen, C.R.; Bulut, O.; Jess, P.

    2008-01-01

    Based on the positive international experience with laparoscopic splenectomy on a large number of patients since 1991, we treated two teenagers with symptomatic hereditary spherocytosis and moderate splenomegaly. Both operations and postoperative courses were uneventful, and the children had...

  14. Alvorlige bivirkninger ved P-pillebrug hos teenagere

    DEFF Research Database (Denmark)

    Nylander, Malin Chatarina; Clausen, Helle V

    2014-01-01

    PubMed-search found studies investigating adverse effects of combined oral contraceptive pills (COC) among teenagers. Four studies found a small negative impact of COC on acquisition of bone mineral density. COC is associated with elevated risk of venous thrombotic events (VTE), especially during...

  15. Alvorlige bivirkninger ved p-pillebrug hos teenagere

    DEFF Research Database (Denmark)

    Nylander, Malin Chatarina; Clausen, Helle V

    2014-01-01

    PubMed-search found studies investigating adverse effects of combined oral contraceptive pills (COC) among teenagers. Four studies found a small negative impact of COC on acquisition of bone mineral density. COC is associated with elevated risk of venous thrombotic events (VTE), especially during...

  16. Steatocystoma multiplex hos 39-årig kvinde

    DEFF Research Database (Denmark)

    Duffy, Jonas Raymond; Siersen, Hans Erik; Bonde, Christian T

    2011-01-01

    -coloured cystic lesions on the chest, abdomen, axillae and back. The patient's clinical presentations and history were compatible with steatocystoma multiplex. Various treatment options for steatocystoma multiplex and steatocystoma multiplex suppurativum have been published and include oral antibiotics...

  17. Arbejdsbetinget Systemisk Sklerodermi hos mænd

    DEFF Research Database (Denmark)

    Zachariae, Hugh; Bjerring, Peter; Søndergaard, Klaus

    1997-01-01

    An analysis of the history of 28 men suffering from systemic sclerosis, diagnosed at our department during the last 25 years, showed that 21 (75%) had been subject to exposures previously suggested to be of importance in occupational scleroderma. The exposures were revealed by patient files......, reports to health authorities, interviews and/or answers to questionnaires. Organic solvents being the most frequent exposure. This was found in thirteen of the patients (46%). A significant difference was found between scleroderma patients and control patients not suffering from connective tissue...

  18. Atypisk femurfraktur hos en patient uden bisfosfonatbehandling

    DEFF Research Database (Denmark)

    Hansen, Henrik Michael; Jensen, Jens-Erik Beck; Hyldstrup, Lars

    2012-01-01

    The present case describes an atypical femur fracture in a patient, who had not previously been treated with bisphosphonate. The patient fulfilled the specific characteristics for an atypical fracture that have recently been suggested by an international expert group. For 15 years after her...... menopause the patient had been treated with oestrogen. Prospective studies to determine the frequency and pathogenesis of these fractures in patients treated with bisphosphonate and in bisphosphonate naïve patients are suggested....

  19. Svaer hyperkaliaemi ved gastroenteritis hos kolektomeret patient

    DEFF Research Database (Denmark)

    Hansen, Lasse Bremholm; Winkel, Rasmus; Hansen, Erik Feldager

    2010-01-01

    Severe hyperkalemia is a life-threatening condition that causes primarily cardiac and muscular dysfunction with potentially fatal consequences. This case report describes a case of severe hyperkalemia (9,1 mmol/l) caused by acute prerenal failure due to dehydration. The severe dehydration was cau...... was caused by a combination of reduced fluid intake due to gastroenteritis and a hampered capacity for intestinal fluid absorption, due to previous colectomy. The patient developed classic signs of hyperkalemia with electrocardiogram changes and muscular dysfunction....

  20. Durability of shrink joints; Bestaendighet hos krympskarvar

    Energy Technology Data Exchange (ETDEWEB)

    Forsaeus Nilsson, Stefan; Saellberg, Sven-Erik

    2007-07-01

    About one third of all joint failures are caused by shrink seals losing adhesion, according to statistics from the Swedish District Heating Association. The present project was initiated upon request from the Authorisation Board of the Swedish District Heating Association in order to investigate the potential to enhance the quality of shrink joints. The purpose has been to provide a screening of the key properties of the joint systems currently available on the market. The aim has been to facilitate the choice of right materials and constructions to achieve the best functionality and cost effectiveness. The project has comprised a compilation of the views from industry representatives from manufacturers of shrink and sealing materials, pipe producers, joint contractors and district heating companies, and an experimental study where a number of joints were evaluated with respect to tightness and strength. The following joint systems took part in the investigation: Logstor SX; Canusa SuperCase; Raychem RayJoint; Powerpipe DTK with external seal Nitto NeoCover 1150 in one end and Raychem TPSM in the other; Logstor B2S med external seal Canusa KLD in one end and Raychem TPSM in the other. The joints were installed on pipes of diameters 160 mm and 450 mm. The installation was done under cold and dirty conditions, to simulate a field like worst-case scenario. After the installation, the joints were tested with respect to tightness. Peel strength and shear strength were evaluated before and after thermal ageing in +50 deg C for 70 days. Mechanical tests and ageing followed standardised procedure in EN 12068. A study of the shrink force relaxation in crosslinked and non-crosslinked polyethylene shrink sleeves was undertaken, by shrinking them onto aluminium cylinders and storing them in room temperature for about 2000 hours. The results show that it is clearly possible to install excellent shrink joints also under difficult conditions. In addition, thermal ageing does not automatically lead to any dramatic changes in material properties. Of the tested variants, all but one was completely tight and the mechanical strength levels were in line with what the manufacturers state in their data sheets for most of the joints. The measured shrink forces show that relaxation is not a big problem. The material in the joint sleeve will continue to strive towards it non-expanded state of equilibrium, and for the non-crosslinked samples, this actually resulted in an increase in shrink force over time. Since the materials and constructions do work, one may indirectly conclude that the problems are mainly caused by the installation, which, in turn, is likely to a large extent a consequence of difficult working conditions and demanding installation procedures. According to experience, the sealing materials are decisive for the ease of installation. From the fitter's point of view, the sealing material should be soft (more forgiving) and fibre reinforced (easier to handle) and it should come in wide strips (easier to apply). When it comes to sleeves, the shrinking work is faster with crosslinked material (PEX). An important observation is also that sleeves with built-in sealant and/or adhesive are harder to keep clean at the work site. Hence, the most important thing is that the installation is done in a proper manner and that appropriate conditions for the fitter to achieve this is provided at the work site. It is hard to single out the best or the worst joint system, but some recommendations may be given: Remember to depressurise the joint during shrinking to avoid unnecessary pressure loads on the seal. Use a sleeve of crosslinked polyethylene if a fast installation is important. If non-crosslinked sleeves are used, choose a double expanded variant. Use a sealing material with easy handling and forgiving characteristics, e.g., the type used for Nitto NeoCover or Raychem TPSM. If extra strength is needed, use a stronger sealant, such as, e.g., a mastic/hotmelt mix such as that used in Canusa KLD. Please note, though, that high strength does not automatically imply good tightness

  1. Intrahepatisk galdesten hos en patient med alkaptonuri

    DEFF Research Database (Denmark)

    Bülow, Charlotte; Rosenberg, Jacob

    2009-01-01

    Alkaptonuria is a rare inherited disease with enzyme deficiency in the protein metabolism. The patients accumulate homogentisic acid which leads to symptoms from various body tissues. We describe a patient with recurrent intrahepatic gallstones probably due to such accumulation, and the successful...

  2. Mundhulens mikroflora hos patienter med marginal parodontitis

    DEFF Research Database (Denmark)

    Larsen, Tove; Fiehn, Nils-Erik

    2011-01-01

    Viden om marginal parodontitis’ mikrobiologi tog for alvor fart for ca. 40 år siden. Den tidlige viden var baseret på mikroskopiske og dyrkningsmæssige undersøgelser af den subgingivale plak. Anvendelsen af de nyere molekylærbiologiske metoder har betydet, at vor viden om de ætiologiske faktorer ...

  3. Hovedpine hos børn og unge

    DEFF Research Database (Denmark)

    Gren, Caroline; Vogler, Kristoffer; Miranda, Maria Jose

    2018-01-01

    Headache is an increasingly common symptom among children and adolescents with a prevalence of 58.4%, and it may have profound impact on everyday life. A poorer prognosis is seen for children, who are not referred to specialist care, and long-term follow-up is shown to indicate a better outcome. ...

  4. Psykiske problemer hos 5-7 årige

    DEFF Research Database (Denmark)

    Skovgaard, Anne Mette; Elberling, Hanne

    2017-01-01

    Resultater fra fødselskohorten CCC2000 viser, at en gruppe børn har betydelige problemer i tiden omkring skolestart, som indikerer, at disse børn vil få vanskeligheder i skoletilværelsen. Dette gælder først og fremmest børn med ASD og ADHD problemstillinger, hvis kognitive vanskeligheder kompromi......Resultater fra fødselskohorten CCC2000 viser, at en gruppe børn har betydelige problemer i tiden omkring skolestart, som indikerer, at disse børn vil få vanskeligheder i skoletilværelsen. Dette gælder først og fremmest børn med ASD og ADHD problemstillinger, hvis kognitive vanskeligheder...... et tidspunkt hvor intervention må forventes at kunne bremse en del af sygdomsudviklingen....

  5. Erhvervsbetinget eksem hos fynske gartnere og gartnerimedhjaelpere

    DEFF Research Database (Denmark)

    Paulsen, E; Søgaard, J; Andersen, Klaus Ejner

    1998-01-01

    The aims of the study were to assess the prevalence of and association between occupational dermatitis and possible risk factors in gardeners and greenhouse workers living on Funen, describe the distribution of different types of eczema and detect the allergens most commonly involved. A cross-sec...

  6. Svaer metabolisk acidose hos en kronisk alkoholiker

    DEFF Research Database (Denmark)

    Sonne, Morten Egede; Rudolph, Søren Finnemann; Pott, Frank Christian

    2008-01-01

    Severe metabolic acidosis is associated with poor prognosis. We present a patient with profound alcohol and starvation-related combined lactic and keto acidosis (lactate = 29 mM; pH = 6.83) who made a good recovery following 18 hours of intensive care therapy. A brief summary of the proposed mech...

  7. Primaer cerebral vaskulitis hos børn

    DEFF Research Database (Denmark)

    Pradsgaard, Dan Østergaard; Stausbøl-Grøn, Brian; Østergaard, John Rosendahl

    2010-01-01

    , in the absence of other known diseases with these findings. MATERIAL AND METHODS: We performed a retrospective review of children below 15 years submitted with CNS vasculitis to the department between 1999 and 2008. RESULTS: Six (two boys, four girls) of ten children with clinical and vascular imaging findings...... detected by magnetic resonance were diagnosed with primary CNS vasculitis. Age at onset was three to 12 years. Acutely acquired hemiparesis was seen in five children, two had facial palsy. Among other symptoms were headache, ataxia, dysarthria, loss of consciousness and seizures. Only modest changes...

  8. Trosbegrebet hos Slavoj Žižek

    DEFF Research Database (Denmark)

    Karlsen, Mads Peter

    2016-01-01

    Hensigten med denne artikel er at give en systematisk fremstilling af Slavoj Žižeks overvejelser over tro for herved at tematisere hans religionsfilosofiske relevans. Der indledes med en kort introduktion til Žižeks grundlæggende filosofiske anliggende og en teologisk kontekstualisering af hans t...

  9. Persisterende pulmonal hypertension hos nyfødte

    DEFF Research Database (Denmark)

    Pedersen, C M; Hansen, T G; Henneberg, Steen Winther

    1997-01-01

    and extracorporal membrane oxygenation. Particular emphasis is placed on the treatment of the condition with inhaled nitric oxide. Nitric oxide is a selective pulmonary vasodilator and able to improve ventilation/ perfusion mismatching in cases where there is an affection of the pulmonary parenchyma. Data from...

  10. Persisterende pulmonal hypertension hos nyfødte

    DEFF Research Database (Denmark)

    Pedersen, C M; Hansen, T G; Henneberg, Steen Winther

    1997-01-01

    On the basis of a review of the literature, a survey is presented concerning persistent pulmonary hypertension of the newborn. In this article the authors focus on the pathophysiology, diagnostic criteria and treatment, including mechanical ventilation, pharmacological vasodilation...

  11. Diagnostisk udfordring hos patienter med infiltrerende tarmendometriose

    DEFF Research Database (Denmark)

    Sloth, Sigurd Beier; Seyer-Hansen, Mikkel

    2014-01-01

    A considerable proportion of women with endometriosis have intestinal involvement of the endometriosis. Intestinal endometriosis (IE) often results in abdominal pain and thus mimics the symptoms of other bowel diseases, including colon cancer. As a consequence, some women with IE are initially...

  12. Persisterende pulmonal hypertension hos nyfødte

    DEFF Research Database (Denmark)

    Pedersen, C M; Hansen, T G; Henneberg, S W

    1997-01-01

    On the basis of a review of the literature, a survey is presented concerning persistent pulmonary hypertension of the newborn. In this article the authors focus on the pathophysiology, diagnostic criteria and treatment, including mechanical ventilation, pharmacological vasodilation and extracorpo......On the basis of a review of the literature, a survey is presented concerning persistent pulmonary hypertension of the newborn. In this article the authors focus on the pathophysiology, diagnostic criteria and treatment, including mechanical ventilation, pharmacological vasodilation...

  13. Forekomst af parodontitis og FORL hos perserkatte

    DEFF Research Database (Denmark)

    Flørnæs, Maria L. Topholm; Lund, Mette; Kortegaard, Hanne Ellen

    2007-01-01

    I dette studie er omfanget af tandrelaterede sygdomme heriblandt parodontitis og feline odontoklastiske resorptions læsioner (FORL) blandt 19 perserkatte (heraf 2 exotics) på 3 til 9 år undersøgt både klinisk og radiografisk. Ingen af kattene havde tidligere fået renset tænder i anæstesi. Alle ka...

  14. Three-dimensional instability of standing waves

    Science.gov (United States)

    Zhu, Qiang; Liu, Yuming; Yue, Dick K. P.

    2003-12-01

    We investigate the three-dimensional instability of finite-amplitude standing surface waves under the influence of gravity. The analysis employs the transition matrix (TM) approach and uses a new high-order spectral element (HOSE) method for computation of the nonlinear wave dynamics. HOSE is an extension of the original high-order spectral method (HOS) wherein nonlinear wave wave and wave body interactions are retained up to high order in wave steepness. Instead of global basis functions in HOS, however, HOSE employs spectral elements to allow for complex free-surface geometries and surface-piercing bodies. Exponential convergence of HOS with respect to the total number of spectral modes (for a fixed number of elements) and interaction order is retained in HOSE. In this study, we use TM-HOSE to obtain the stability of general three-dimensional perturbations (on a two-dimensional surface) on two classes of standing waves: plane standing waves in a rectangular tank; and radial/azimuthal standing waves in a circular basin. For plane standing waves, we confirm the known result of two-dimensional side-bandlike instability. In addition, we find a novel three-dimensional instability for base flow of any amplitude. The dominant component of the unstable disturbance is an oblique (standing) wave oriented at an arbitrary angle whose frequency is close to the (nonlinear) frequency of the original standing wave. This finding is confirmed by direct long-time simulations using HOSE which show that the nonlinear evolution leads to classical Fermi Pasta Ulam recurrence. For the circular basin, we find that, beyond a threshold wave steepness, a standing wave (of nonlinear frequency Omega) is unstable to three-dimensional perturbations. The unstable perturbation contains two dominant (standing-wave) components, the sum of whose frequencies is close to 2Omega. From the cases we consider, the critical wave steepness is found to generally decrease/increase with increasing radial

  15. Automated oral cancer identification using histopathological images: a hybrid feature extraction paradigm.

    Science.gov (United States)

    Krishnan, M Muthu Rama; Venkatraghavan, Vikram; Acharya, U Rajendra; Pal, Mousumi; Paul, Ranjan Rashmi; Min, Lim Choo; Ray, Ajoy Kumar; Chatterjee, Jyotirmoy; Chakraborty, Chandan

    2012-02-01

    Oral cancer (OC) is the sixth most common cancer in the world. In India it is the most common malignant neoplasm. Histopathological images have widely been used in the differential diagnosis of normal, oral precancerous (oral sub-mucous fibrosis (OSF)) and cancer lesions. However, this technique is limited by subjective interpretations and less accurate diagnosis. The objective of this work is to improve the classification accuracy based on textural features in the development of a computer assisted screening of OSF. The approach introduced here is to grade the histopathological tissue sections into normal, OSF without Dysplasia (OSFWD) and OSF with Dysplasia (OSFD), which would help the oral onco-pathologists to screen the subjects rapidly. The biopsy sections are stained with H&E. The optical density of the pixels in the light microscopic images is recorded and represented as matrix quantized as integers from 0 to 255 for each fundamental color (Red, Green, Blue), resulting in a M×N×3 matrix of integers. Depending on either normal or OSF condition, the image has various granular structures which are self similar patterns at different scales termed "texture". We have extracted these textural changes using Higher Order Spectra (HOS), Local Binary Pattern (LBP), and Laws Texture Energy (LTE) from the histopathological images (normal, OSFWD and OSFD). These feature vectors were fed to five different classifiers: Decision Tree (DT), Sugeno Fuzzy, Gaussian Mixture Model (GMM), K-Nearest Neighbor (K-NN), Radial Basis Probabilistic Neural Network (RBPNN) to select the best classifier. Our results show that combination of texture and HOS features coupled with Fuzzy classifier resulted in 95.7% accuracy, sensitivity and specificity of 94.5% and 98.8% respectively. Finally, we have proposed a novel integrated index called Oral Malignancy Index (OMI) using the HOS, LBP, LTE features, to diagnose benign or malignant tissues using just one number. We hope that this OMI can

  16. Aerobic fitness testing in 6- to 9-year-old children: reliability and validity of a modified Yo–Yo IR1 test and the Andersen test

    DEFF Research Database (Denmark)

    Ahler, Thomas

    2011-01-01

    Målet med dette studie var at undersøge to indirekte VO2max tests (Yo–Yo IR1 og Andersen test) hos en gruppe 0 og 2. klasses børn mht. reproducerbarhed og mht. validitet i relation til en direkte målt VO2max. 35 skolelever i alderen 6-9 år blev inkluderet i studiet (18 fra 0., og 17 fra 2. klasse...

  17. Tilbagebetaling af sociale ydelser

    DEFF Research Database (Denmark)

    Hielmcrone, Nina Elisabeth von

    konstateres, at der foreligger fejl og forsømmelser hos både modtager og myndighed. Dermed stilles der også spørgsmålstegn ved de såkaldt "objektive" tilbagebetalingsbestemmelser som f.x. i boligstøttelovens § 47 stk. 1 og 2.       Bogen behandler desuden de mange og vanskelige fortolkningsproblemer, der...... knytter sig til anvendelsen af tilbagebetalingsbestemmelserne i de sociale love....

  18. Negative cancer beliefs, recognition of cancer symptoms and anticipated time to help-seeking

    DEFF Research Database (Denmark)

    Pedersen, Anette Fischer; Forbes, Lindsay; Brain, Kate

    2018-01-01

    Tidlig diagnostik af kræftsygdomme kræver, at vi ved, hvad der kan anspore eller stå i vejen for lægesøgning hos personer med symptomer på mulig kræft. Denne undersøgelse viser, at personer med godt kendskab til kræftsymptomer og/eller få negative holdninger til kræft angiver, at de ville søge læ...

  19. Selen og vitamin E til søer og pattegrise

    DEFF Research Database (Denmark)

    Nielsen, H. E.; Danielsen, V.; Simesen, M. G.

    1977-01-01

    Formålet med dette forsøg var at undersøge virkningen af foderets selen- og vitamin E indhold på søernes frugtbarhed og pattegrisenes levedygtighed og vækst. Endvidere at undersøge koncentrationen af selen (Se) og vitamin E i råmælk, somælk og blod i relation til foderet. Der forekom enkelte...... dødsfald blandt grisene, som kunne sættes i forbindelse med enten lavt Se-indhold eller lavt vitamin E indhold i foderet. Der blev desuden konstateret flere brunst- og drægtighedsproblemer hos søer, derfik foder med det lave indhold af vitamin E end hos søer i de andre grupper. En forøgelse af Se......-indholdet fra 30 til 60 µg pr. kg foder gav en fordobling af indholdet i råmælk og i somælk. En forøgelse af vitamin E indholdet i foderet fra ca. 20 mg til ca. 45 mg pr. kg foder gav 4 gange forøgelse i råmælk og somælk. Der blev konstateret tilsvarende virkninger af Se og vitamin E i foderet på indholdet i...

  20. Physical Therapy Protocol After Hip Arthroscopy: Clinical Guidelines Supported by 2-Year Outcomes.

    Science.gov (United States)

    Domb, Benjamin G; Sgroi, Terrance A; VanDevender, Jeremy C

    2016-07-01

    Femoroacetabular impingement (FAI) was first described by Ganz in 2003 and is a significant cause of decreased function and mobility. Femoroacetabular impingement must be treated in an individualized, goal-oriented, stepwise fashion. This protocol was developed with biomechanical considerations of soft tissue and bony structures surrounding the hip joint. The PubMed database was searched for scientific and review articles from the years 2000 to 2015 utilizing the search terms: hip rehabilitation, femoroacetabular impingement, and arthroscopy. Clinical review. Level 5. Five hundred ninety-five of 738 patients were available for follow-up showing improvement from preoperative to 2-year follow-up of 61.29 to 82.02 for modified Harris Hip Score (mHHS), 62.79 to 83.04 for Hip Outcome Score-Activities of Daily Living (HOS-ADL), 40.96 to 70.07 for Hip Outcome Score-Sport-Specific Subscale (HOS-SSS), and 57.97 to 80.41 for Non-Arthritic Hip Score (NAHS); visual analog scale (VAS) scores decreased from 5.86 preoperatively to 2.94 postoperatively. Following a structured, criteria-based program, appropriate patients undergoing hip arthroscopy may achieve excellent outcomes and return to full independent activities of daily living as well as sport. © 2016 The Author(s).

  1. Motivation og handlingskapacitet

    DEFF Research Database (Denmark)

    Andersen, Lotte Bøgh; Kristensen, Nicolai; Pedersen, Lene Holm

    2012-01-01

    Der har i flere år være en interesse for at undersøge motivationen hos producenterne af offentlige ydelser, mens der i mindre grad findes empiriske analyser af brugernes handlingskapacitet. Artiklen råder bod på dette ved at analysere forskelle i motivation og handlingskapacitet på fire serviceom......Der har i flere år være en interesse for at undersøge motivationen hos producenterne af offentlige ydelser, mens der i mindre grad findes empiriske analyser af brugernes handlingskapacitet. Artiklen råder bod på dette ved at analysere forskelle i motivation og handlingskapacitet på fire...... serviceområder (skoler, dagpasning, hospitaler og videregående uddannelser). Der anvendes henholdsvis et veletableret mål for public service motivation (n=377 producenter) og et nyudviklet mål for handlingskapacitet (n=1056 brugere). Resultaterne viser, at der er relativt højest handlingskapacitet og public...... service motivation på daginstitutionsområdet efterfulgt af skoleområdet, mens de videregående uddannelser placerer sig relativt lavest på begge variable. Hospitalsbrugerne har næsten lige så lav handlingskapacitet som brugerne af de videregående uddannelser, mens de hospitalsansattes public service...

  2. Vehicle Speed Estimation and Forecasting Methods Based on Cellular Floating Vehicle Data

    Directory of Open Access Journals (Sweden)

    Wei-Kuang Lai

    2016-02-01

    Full Text Available Traffic information estimation and forecasting methods based on cellular floating vehicle data (CFVD are proposed to analyze the signals (e.g., handovers (HOs, call arrivals (CAs, normal location updates (NLUs and periodic location updates (PLUs from cellular networks. For traffic information estimation, analytic models are proposed to estimate the traffic flow in accordance with the amounts of HOs and NLUs and to estimate the traffic density in accordance with the amounts of CAs and PLUs. Then, the vehicle speeds can be estimated in accordance with the estimated traffic flows and estimated traffic densities. For vehicle speed forecasting, a back-propagation neural network algorithm is considered to predict the future vehicle speed in accordance with the current traffic information (i.e., the estimated vehicle speeds from CFVD. In the experimental environment, this study adopted the practical traffic information (i.e., traffic flow and vehicle speed from Taiwan Area National Freeway Bureau as the input characteristics of the traffic simulation program and referred to the mobile station (MS communication behaviors from Chunghwa Telecom to simulate the traffic information and communication records. The experimental results illustrated that the average accuracy of the vehicle speed forecasting method is 95.72%. Therefore, the proposed methods based on CFVD are suitable for an intelligent transportation system.

  3. Automated characterization of diabetic foot using nonlinear features extracted from thermograms

    Science.gov (United States)

    Adam, Muhammad; Ng, Eddie Y. K.; Oh, Shu Lih; Heng, Marabelle L.; Hagiwara, Yuki; Tan, Jen Hong; Tong, Jasper W. K.; Acharya, U. Rajendra

    2018-03-01

    Diabetic foot is a major complication of diabetes mellitus (DM). The blood circulation to the foot decreases due to DM and hence, the temperature reduces in the plantar foot. Thermography is a non-invasive imaging method employed to view the thermal patterns using infrared (IR) camera. It allows qualitative and visual documentation of temperature fluctuation in vascular tissues. But it is difficult to diagnose these temperature changes manually. Thus, computer assisted diagnosis (CAD) system may help to accurately detect diabetic foot to prevent traumatic outcomes such as ulcerations and lower extremity amputation. In this study, plantar foot thermograms of 33 healthy persons and 33 individuals with type 2 diabetes are taken. These foot images are decomposed using discrete wavelet transform (DWT) and higher order spectra (HOS) techniques. Various texture and entropy features are extracted from the decomposed images. These combined (DWT + HOS) features are ranked using t-values and classified using support vector machine (SVM) classifier. Our proposed methodology achieved maximum accuracy of 89.39%, sensitivity of 81.81% and specificity of 96.97% using only five features. The performance of the proposed thermography-based CAD system can help the clinicians to take second opinion on their diagnosis of diabetic foot.

  4. Intergenerational care in the Danish welfare society

    DEFF Research Database (Denmark)

    Singla, Rashmi

    2015-01-01

    individualisme og solidaritet i den danske velfærdsstat. Gennem analyser af disse data udforskes aktuelle idealer og praktikker i hverdagens omsorgsrelationer hos såvel etniske minoriteter som majoriteter. Resultaterne udfordrer kulturelle stereotyper og hverdagsforståelser, som får os til at tro, at etniske...... individuel livsorientering ikke udelukker intergenerationel solidaritet i den danske velfærdsstat. Keywords: intergenerational care, individualisation, communality/ interconnectedness, social network analysis, ideals, everyday practices, social psychology....

  5. Gennemgang af den danske samfundsregulering

    DEFF Research Database (Denmark)

    Falch, Morten

    investeringer hos en bred række af markedsaktører’1. Midlet til at opnå dette mål har været at skabe et regelsæt der gør det lettere for nye virksomheder at komme ind på det nye telemarked, og konkurrere på lige fod med TDC. Herudover, har man hjulpet de nye operatører på vej gennem en såkaldt asymmetrisk...

  6. Rapportering af diagnostiske undersøgelser af faldvildt 2014

    DEFF Research Database (Denmark)

    Chriél, Mariann; Hansen, Mette Sif; Larsen, Gitte

    . Udbruddet startede i april i Sverige og sluttede i efteråret i Holland. Der var under udbruddet ingen tegn på smitte til gråsæler. Den zoonotiske parasit Echinococcus multilocularis er igen i år påvist i ræve og for første gang er parasitten påvist hos 2 mårhunde. Der mærkes en stor interesse fra borgere og...

  7. Cutting og anden form for selvskade

    DEFF Research Database (Denmark)

    Møhl, Bo; Møhl Schack, Malthe

    2013-01-01

    Selvskade, en metode til nedregulering eller dæmpning af svære følelser, er desværre et hyppigt fænomen. Aktiviteten er forbundet med skam og vækker også mange følelser hos behandleren, der let kommer til at føle både vrede og magtesløshed. Bliv klogere på, hvad adfærden dækker over, hvordan den ...

  8. Prescribing quality for older people in Norwegian nursing homes and home nursing services using multidose dispensed drugs

    OpenAIRE

    Halvorsen, Kjell H.; Granås, Anne Gerd; Engeland, Anders; Ruths, Sabine

    2012-01-01

    Tverrsnittstudie, undersøker og sammenligner forskrivningskvaliteten hos eldre som bor i sykehjem og hjemme. Purpose: to examine and compare the quality of drug prescribing for older patients in nursing homes and home nursing services. Methods: Cross-sectional study comprising 11 254 patients aged ≥65 years in nursing homes (n = 2986) and home nursing services (n = 8268). Potentially inappropriate medications were identified by using the Norwegian General Practice criteria and drug–drug in...

  9. CUTANEOUS MANIFESTATIONS OF CHRONIC RENAL FAILURE AND RENAL TRANSPLANTATION

    OpenAIRE

    R. Suganya Gnanadeepam; S. Kayalvizhi Money

    2017-01-01

    BACKGROUND The kidney and the skin are the two large networks of the body with abundant blood supply associated with various cutaneous manifestations. This study aims to detect the various cutaneous manifestations and its incidence in patients with chronic renal failure and renal transplantation. MATERIALS AND METHODS This study was done for a period of 1 year from January 2016 to December 2016 at Nephrology OPD ward and Medicine wards, Government KAPV Medical College Hos...

  10. Det protestantiske selv

    DEFF Research Database (Denmark)

    Dalsgaard, Matias Møl

    tænkere som Charles Taylor og Max Weber har gennemført. Men undersøgelsens fokus er i højere grad på selvets liv end på moralitet og økonomi som det er tilfældet hos Taylor og Weber. Primært gennem en læsning af Søren Kierkegaard og sekundært gennem en analyse af nyere æstetiske produktioner forsøger...

  11. Forbrugerinteresse i at spise insekter

    DEFF Research Database (Denmark)

    Videbæk, Pernille Nørgaard; Grunert, Klaus G

    2017-01-01

    Potentielle entomofager. Dette sidste segment udgør 28% i undersøgelsen og har en overvægt af højtuddannede mænd. Der er også flere i dette segment der har prøvet at smage insekter før. Undersøgelsen viser også at sociale normer spiller en større rolle end forventet hos forbrugerne, og det vil være nødvendigt...

  12. Simulation of breaking waves using the high-order spectral method with laboratory experiments: Wave-breaking onset

    Science.gov (United States)

    Seiffert, Betsy R.; Ducrozet, Guillaume; Bonnefoy, Félicien

    2017-11-01

    This study investigates a wave-breaking onset criteria to be implemented in the non-linear potential flow solver HOS-NWT. The model is a computationally efficient, open source code, which solves for the free surface in a numerical wave tank using the High-Order Spectral (HOS) method. The goal of this study is to determine the best method to identify the onset of random single and multiple breaking waves over a large domain at the exact time they occur. To identify breaking waves, a breaking onset criteria based on the ratio of local energy flux velocity to the local crest velocity, introduced by Barthelemy et al. (2017) is selected. The breaking parameter is uniquely applied in the numerical model in that calculations of the breaking onset criteria ratio are not made only at the location of the wave crest, but at every point in the domain and at every time step. This allows the model to calculate the onset of a breaking wave the moment it happens, and without knowing anything about the wave a priori. The application of the breaking criteria at every point in the domain and at every time step requires the phase velocity to be calculated instantaneously everywhere in the domain and at every time step. This is achieved by calculating the instantaneous phase velocity using the Hilbert transform and dispersion relation. A comparison between more traditional crest-tracking techniques shows the calculation of phase velocity using Hilbert transform at the location of the breaking wave crest provides a good approximation of crest velocity. The ability of the selected wave breaking criteria to predict single and multiple breaking events in two dimensions is validated by a series of large-scale experiments. Breaking waves are generated by energy focusing and modulational instability methods, with a wide range of primary frequencies. Steep irregular waves which lead to breaking waves, and irregular waves with an energy focusing wave superimposed are also generated. This set of

  13. Case01: BIM hos mindre arkitektrådgiver

    DEFF Research Database (Denmark)

    Vestergaard, Flemming; Karlshøj, Jan; Hauch, Peter

    Casen beskriver et IKT-koncept, hvor en hovedrådgiver, en mindre arkitektvirksomhed specialiseret i renovering og ombygning af mindre boligprojekter, anvender en modelbaseret arbejdsmetode i tre hovedleverancer for tegnestuen: et dispositionsplanforslag, et forprojekt/myndighedsprojekt og et ho-v...

  14. Inventarium: Medier og maskiner hos Henrich von Kleist

    OpenAIRE

    Jacobsen, Yngve Sandhei

    2002-01-01

    Litteraturen fra begynnelsen av 1800-tallet har ofte blitt lest som en ganske enkel flukt fra det moderne livets kompleksitet i retning av den skjønne kunsten, naturen og sjelen. Gjennom besjelingen av en ytre natur og fordypingen i egen inderlighet forsøker den romantiske dikteren visstnok å gjenreise en enhet som er i ferd med å gå tapt. Tegnene på den industrielle revolusjon kommer dermed til uttrykk i et slags negativformat: Ikke gjennom hva hvert enkelt diktverk sier, men gjennom hva det...

  15. Forekomst af Chlamydia trachomatis hos værnepligtige

    DEFF Research Database (Denmark)

    Søgaard, P; Møller, B R; Thorsen, Poul

    1996-01-01

    among Chlamydia positive men was 6. The frequency of earlier VD was 7.5% and 10% among men and women, respectively. Treatment with tetracycline was effective, which makes control of eradication unnecessary. We conclude that genital chlamydial infection among young asymptomatic people is common...

  16. Kirurgisk behandling af fedme hos børn

    DEFF Research Database (Denmark)

    Hansen, Ann Berit; Gögenur, Ismail; Støckel, Mikael

    2014-01-01

    Morbid obesity in teenagers has become an increasing problem. Conventional diet has not yet shown effective long-term weight loss. Alternatively, bariatric surgery on adolescents has resulted in substantial weight loss, recovery from diabetes, improvement of cardiovascular risk factors and improv......Morbid obesity in teenagers has become an increasing problem. Conventional diet has not yet shown effective long-term weight loss. Alternatively, bariatric surgery on adolescents has resulted in substantial weight loss, recovery from diabetes, improvement of cardiovascular risk factors...... and improvement in psychosocial status. Still, surgery performed on adolescents provides ethical challenges such as the unknown long-term prognosis after surgery. Despite these challenges, in cases of severe intractable obesity or development of life-threatening complications due to obesity, surgery should...

  17. Selvadministreret ventrikelsondeernaering hos et barn med infantil autisme

    DEFF Research Database (Denmark)

    Dyrborg, J

    1991-01-01

    An example of self-administered gastric tube nutrition in a boy aged 15 years with infantile autism is presented. The boy would neither eat nor drink in the normal manner since the age of eight years and has gradually administered tube-feeding himself. This patient does not fulfill the internatio......An example of self-administered gastric tube nutrition in a boy aged 15 years with infantile autism is presented. The boy would neither eat nor drink in the normal manner since the age of eight years and has gradually administered tube-feeding himself. This patient does not fulfill...... the international criteria for the diagnosis of anorexia nervosa. A possible etiological factor and the education/psychological attitudes to the compulsive symptom are discussed. Udgivelsesdato: 1991-Oct-14...

  18. Laktatacidose hos en yngre kvinde med status asthmaticus

    DEFF Research Database (Denmark)

    Ramazan-Yousif, Lana; Albertsen, Signe; Bergmann, Troels K

    2017-01-01

    A 24-year-old woman with asthma presented with symptoms of upper airway infection and tachypnoea and wheezes. She had a history of admissions to intensive care units (ICU) due to respiratory insufficiency. The initial lactate concentration was 2.1 mmol/l. The treatment consisted of inhaled...... and intravenous β ² agonists. Hereafter, the lactate concentration rose to 9.8 mmol/l, and the patient was admitted to the ICU due to severe asthma exacerbation. The elevation of lactate concentration cleared after discontinuation of β ² agonist therapy. Although lactic acidosis is a rare side effect to β...

  19. Bisfosfonatassocieret osteonekrose i kaeberne hos patienter med myelomatose

    DEFF Research Database (Denmark)

    Lund, Thomas; Gregersen, Henrik; Vangsted, Annette

    2009-01-01

    of bisphosphonate therapy and with the potency of the used bisphosphonate. BON usually develops after tooth extraction or other oral surgery, and has proven difficult to treat. Optimal dental hygiene should be ensured prior to treatment initiation where possible, and once bisphosphonate treatment is instituted......, oral surgery should be avoided if possible. Udgivelsesdato: 2009-Jan-5...

  20. Forekomst af alkohol, narkotika og medicin hos bilister

    DEFF Research Database (Denmark)

    Bernhoft, Inger Marie

    2011-01-01

    Inden for rammerne af det fælles-europæiske forskningsprojekt DRUID (DRiving Under the Influence of Drugs, alcohol and medicines) er forekomsten af alkohol og/eller andre stoffer blevet undersøgt i et stort antal europæiske lande, bl.a. i Danmark.......Inden for rammerne af det fælles-europæiske forskningsprojekt DRUID (DRiving Under the Influence of Drugs, alcohol and medicines) er forekomsten af alkohol og/eller andre stoffer blevet undersøgt i et stort antal europæiske lande, bl.a. i Danmark....

  1. Emosjonsregulering og motivasjon hos barn med AD/HD

    DEFF Research Database (Denmark)

    Høvik, Marie Farstad; Plessen, Kerstin J

    2010-01-01

    Impaired cognitive control functions have long been regarded as the main problem in the development of Attention-Deficit/Hyperactivity Disorder (ADHD). A more recent model emphasizes the importance of emotional and motivational problems. We have reviewed the evidence for this model, which may have...

  2. Akut underernæring hos børn

    DEFF Research Database (Denmark)

    Rytter, Maren Johanne Heilskov; Michaelsen, Kim F.; Friis, Henrik

    2017-01-01

    The prevalence of malnutrition has declined significantly over the last 30 years. Despite this, malnutrition remains a major cause of illness and death among children worldwide, particularly in low- and medium-income countries. Marasmus and kwashiorkor are the most life-threatening forms...... of malnutrition. Treatment protocols enable effective treatment, but only a minority of malnourished children have access to treatment. Furthermore, treating children with complicated malnutrition requiring hospitalization remains a clinical challenge....

  3. Medicinsk behandling af osteoporose hos mænd

    DEFF Research Database (Denmark)

    Eiken, Pia A; Vestergaard, Peter

    2016-01-01

    One in five men over the age of 50 years will suffer an osteoporotic fracture during their lifetime, and men who sustain fractures have an increased mortality risk compared to women. Three bisphosphonates (alendronate, risedronate and zolendronic acid), denosumab, strontium ranelate...

  4. Medicinsk behandling af osteoporose hos mænd

    DEFF Research Database (Denmark)

    Eiken, Pia A; Vestergaard, Peter

    2015-01-01

    One in five men over the age of 50 years will suffer an osteoporotic fracture during their lifetime, and men who sustain fractures have an increased mortality risk compared to women. Three bisphosphonates (alendronate, risedronate and zolendronic acid), denosumab, strontium ranelate...

  5. 1 Stress hos tamrein 2 Arbeidsgruppe om forskning

    Directory of Open Access Journals (Sweden)

    Sven Skjenneberg (ed.

    1985-05-01

    Full Text Available 1 NOR har adoptert et opprinnelig svensk prosjekt for å klarlegge i hvilken grad moderne reindriftsteknologi kan tenkes å påvirke reinen slik at det utvikles symptomer på stress. Det er særlig to forhold som har gjort NOR interessert i et slikt prosjekt, nemlig stressforandringers innvirkning på kjøttkvalitet samt i hvilken grad stresspåvirkninger kan medføre langtidseffekter som har innvirkning på dyrenes overlevelsesevne under vanskelige vinterforhold, altså på reintapenes størrelse. Begge disse to momenter har direkte innvirkning på reinnæringens økonomi.2 Forskning, veiledning og utdanning i reindriften i Norge.Den arbeidsgruppe som det norske Landbruksdepartementet den 30. august 1983 oppnevnte for å utrede ovennevnte tema, avga 14. mai 1985 sin betenkning. Denne skisserer gruppens forslag til langtidsplan.

  6. strong>Recirkulering af fosfor hos malkekøerstrong>

    DEFF Research Database (Denmark)

    Puggaard, Liselotte; Kristensen, Niels Bastian; Sehested, Jakob

    2010-01-01

    . Fosforindtag og udskillelse med gødning var lavere ved LP, og den tilsyneladende fordøjelighed (foder-fæces forskel) faldt derfor også. Endelig faldt fosforbalancen til 0 på LP. Plasma og vomkoncentrationen var lavere ved LP, men der var ingen forskel på vom pH, ammonium- eller VFA koncentration. Der var ingen...

  7. Stresshyperglykaemi hos et barn med svaer akut gastroenteritis

    DEFF Research Database (Denmark)

    Bjerre, Jesper V.

    2002-01-01

    A case of a two years and ten months old girl with severe acute gastroenteritis, dehydration, and hyperglycaemia is described. Transient hyperglycaemia is a common clinical finding in children under stress. We discuss the distinction between hyperglycaemia as a prediabetic state and that as a phy......A case of a two years and ten months old girl with severe acute gastroenteritis, dehydration, and hyperglycaemia is described. Transient hyperglycaemia is a common clinical finding in children under stress. We discuss the distinction between hyperglycaemia as a prediabetic state...

  8. Parvovirus B19-akut hepatitis hos immunkompetent patient

    DEFF Research Database (Denmark)

    Larsen, Lykke

    2011-01-01

    This article describes a case of acute hepatitis in an adult person without subsequent complications caused by parvovirus B19 (PVB19). The diagnosis was made by detection of PVB19 IgM and IgG antibody in the blood using ELISA. There was not made any affirmative polymerase chain reaction for DNA...

  9. Udredning af knude på halsen hos voksne

    DEFF Research Database (Denmark)

    Larsen, Christian Grønhøj; Channir, Hani Ibrahim; Kiss, Katalin

    2015-01-01

    Doctors are frequently presented to patients with a neck mass, and the condition might cause diagnostic challenges. In younger adults, a neck mass can typically be explained by congenital, inflammatory or infectious causes. The highest probability of neoplasms is found in patients above 40 years ...

  10. Ustabil rygfraktur hos en patient med paranoid skizofreni

    DEFF Research Database (Denmark)

    Ydemann, Mogens

    2012-01-01

    The misdiagnosis of somatic illness in the psychiatric population can have grave consequences. Somatic symptoms are easily overseen or misinterpreted and a careful history and examination is essential when approaching this group of patients. We report a case of a patient with a history of paranoid...

  11. Collum femoris-fraktur hos en patient med osteopetrose

    DEFF Research Database (Denmark)

    Ghasemi, Habib; Nielsen, Frank Arne Farsø; Lamm, Martin

    2015-01-01

    Osteopetrosis is a rare hereditary bone disease characterized by increased bone density. Patients with adult osteopetrosis are often diagnosed incidentally by Xray or on the presence of recurrent fractures. Internal fixations of fractures in patients with osteopetrosis are challenging due to the ...

  12. Venøse tromboser hos børn

    DEFF Research Database (Denmark)

    Tuckuviene, Ruta; Johnsen, Søren Paaske; Helgestad, Jon

    2008-01-01

    Venous thromboembolism is a rare condition in children, but the incidence appears to be increasing. Newborns and teenagers are at the highest risk of thrombosis, which is often triggered by a combination of risk factors, in particular: infection, central venous line or chemotherapy. The impact...... of thrombophilia is uncertain. International guidelines recommend screening for thrombophilia as part of the diagnostic set-up in children with thrombosis. Treatment of paediatric thrombosis with low-molecular-weight heparin appears safe, but the effectiveness remains to be established. Udgivelsesdato: 2008-Oct-20...

  13. Traumatisk distal humerus-epifysiolyse hos nyfødt

    DEFF Research Database (Denmark)

    Al-Aubaidi, Zaid; Nielsen, Keld Daubjerg

    2010-01-01

    Traumatic distal humerus epiphysiolysis (TDHE) is a rare injury in infants with an incidence of about 1:35,000 births. It is primarily a birth injury, but it is also seen in cases of battered child syndrome. Because of its rare occurrence and the diagnostic difficulties, the lesion may be overloo......Traumatic distal humerus epiphysiolysis (TDHE) is a rare injury in infants with an incidence of about 1:35,000 births. It is primarily a birth injury, but it is also seen in cases of battered child syndrome. Because of its rare occurrence and the diagnostic difficulties, the lesion may...

  14. Risikofaktorer for selvmord hos patienter med dissemineret sklerose

    DEFF Research Database (Denmark)

    Stenager, E N; Koch-Henriksen, N J; Stenager, E

    1997-01-01

    with respect to risk factors comparisons were made for male and female suicides, and for various groups of MS suicides according to disability status. The male suicides were characterized by a tendency to commit suicide in the age interval 40-49 years, the use of a violent method, previous suicidal behaviour......The purpose of the present study was to describe risk factors for suicide in patients with multiple sclerosis (MS). The study is based on available information about MS-patients identified in the Danish MS Registry with onset of disease in the period 1950-1985. In order to characterize MS suicides......, previous mental disorder, recent deterioration of MS, and moderate disability. For women the characteristics were less distinct. Patients with a severe course of MS had been subjected to more risk factors before the suicide. Careful counselling and good information to MS-patients are advocated....

  15. Kronisk tarmiskæmi hos en yngre patient

    DEFF Research Database (Denmark)

    Hansen, Lars Koch; Kammerlander, Heidi; Cecere, Stefano

    2012-01-01

    A 46 year-old woman presented with classic symptoms. Computed tomography-angiography and duplex ultrasonography showed stenosis of the aa. mesenteria superior et inferior. The patient was moved to a university hospital and a percutaneous transluminal angioplasty with insertion of stents was perfo......A 46 year-old woman presented with classic symptoms. Computed tomography-angiography and duplex ultrasonography showed stenosis of the aa. mesenteria superior et inferior. The patient was moved to a university hospital and a percutaneous transluminal angioplasty with insertion of stents...... was performed. She was discharged shortly after feeling well....

  16. Water retention properties of ashes; Vattenretentionsegenskaper hos aska

    Energy Technology Data Exchange (ETDEWEB)

    Hemstroem, Kristian; Ezziyani, Samir; Bendz, David

    2009-05-15

    The water holding properties of a material can be described with a water retention curve (also called pF curve or characteristic curve). The importance of this material property has until now been neglected in waste and rest products contexts. There is an eminent need for knowledge of the water holding properties of ash and rest products in order to improve the possibility to perform i) assessment of leaching from rest product used in constructions, ii) dimensioning of covers built with rest products and iii) assessment of long term properties of land fill waste concerning leaching, especially for stabilized ash with a monolithic characteristics. The aim of this project was to increase the knowledge of the water holding properties of ashes by determining water retention curves with laboratory methods on four ash materials with the potential to be used in constructions. In the project, four ashes has been studied; one MSWI bottom ash from SYSAV, one aged MSWI bottom ash from Gaerstadverket and two fly ashes from incineration of biofuels; one from SCA Ortviken and one from Jaemtkraft AB. For comparison, data from a silt soil studied in another SGI project is presented. When determining a water retention curve for a specific material water from the examined, beforehand water saturated, sample is eliminated under controlled circumstances in a pressure plate extractor. The sample is exposed to a pressure, with increasing degree, squeezing excess water out of the material. The excess water is measured for each increased pressure step and the remaining volumetric water content in the material can be calculated. The results from such measurements are presented in water retention curves, in which the volumetric water content is plotted as a function of the capillary pressure. The water retention curves shows how various materials differ in water content at the same pressure. The results from the study showed that ashes have great water holding capacity. The study also showed that particle size distribution is an inadequate indicator of what water holding properties that can be expected from bottom ashes; the studied MSWI bottom ashes' water holding properties were much greater than natural materials with comparable particle size distribution. This is probably due to the fact that the ash particles have a porous structure, and a special composition, which is of great importance for the water holding properties. The water retention properties of ashes could be determined with a pressure plate extractor in a satisfactory way. In order to improve the determination of the water holding properties of bottom ashes it would be of importance to develop the test procedure further in order to make it possible to test particle fractions larger than 2 mm, which was the upper limit in the test procedure used in this study

  17. Bisfosfonatassocieret osteonekrose i kaeberne hos patienter med myelomatose

    DEFF Research Database (Denmark)

    Lund, Thomas; Gregersen, Henrik; Vangsted, Annette

    2009-01-01

    of bisphosphonate therapy and with the potency of the used bisphosphonate. BON usually develops after tooth extraction or other oral surgery, and has proven difficult to treat. Optimal dental hygiene should be ensured prior to treatment initiation where possible, and once bisphosphonate treatment is instituted...

  18. Medicinsk behandling af vandladningsproblemer hos mænd

    DEFF Research Database (Denmark)

    Andersen, Jens Thorup; Nordling, Jørgen; Walter, Steen

    2007-01-01

    and antimuscarinic agents is reviewed with suggestions for follow-up. The increasing use of alpha-blockers, 5-alpha-reductase inhibitors, or both for symptomatic BPH has led to a significant decrease in the number of operations for BPH in the last decade. Bothersome nocturia due to nocturnal polyuria may be resolved...

  19. Residualurin hos patienter på en geriatrisk afdeling

    DEFF Research Database (Denmark)

    Pedersen, Hanne; Nielsen, Jeanne; Juncher, Annie Elena

    2010-01-01

    Post Void Residual Volume (PVRV) is a known risk factor for urinary infection, incontinence and renal insufficiency. Disposing for the condition is high age, immobility, constipation, neurological and metabolic disease. The objectives of this study were to determine the prevalence and to examine...... risk factors for high PVRV among geriatric patients....

  20. Brugen af personas hos danske virksomheder - 2012/13

    DEFF Research Database (Denmark)

    Nielsen, Lene; Nielsen, Kira Storgaard

    2013-01-01

    Denne rapport er skrevet på baggrund af et projekt initieret og finansieret af InfinIT – Innovationsnetværket for IT. Formålet med projektet er at undersøge hvorledes personas i dag etableres, kommunikeres, anvendes og vedligeholdes i forskellige typer af virksomheder samt etablere et opdateret sæt...... af anbefalinger for deres anvendelse. Virksomheders erfaringer med personas vil blive adresseret fra to forskellige vinkler:. Fokus vil bl.a. være på hvordan personas udvikles og vedligeholdes, om og hvordan de bruges, og hvad de bruges til. Personas er beskrivelser af fiktive brugere og bruges i...... designprocesser. Beskrivelserne er skabt på baggrund af data indsamlet om slutbrugerne. En samling af personas, som regel mellem 2 og 6 beskrivelser, vil i denne rapport benævnes et personasæt. Når personabeskrivelserne indgår i designprocessen bruges de til at få ideer til og beskrive, hvordan brugerne vil...

  1. Hvordan diagnosticerer man astma hos børn?

    DEFF Research Database (Denmark)

    Hermann, Christian

    1997-01-01

    Astma og astmatisk bronkit har ens symptomatologi og behandling og kan med vore dages effektive og bivirkningssvage medicin selv i de lettere grader behandles. Symptomerne kender vi i praksis fra op mod 1/3 af småbørnene, kunsten består i at stille behandlingsindikationen. Der opridses overvejende...... udfra kliniske kriterier enkle retningslinier, der nyder konsensus blandt danske almenmedicinere og pædiatere til hjælp i den daglige håndtering af sådanne symptomer i almen praksis. Til slut understreges, at opsporing af astma og astmatisk bronkitis naturligt hører hjemme i almen praksis, og...

  2. Kirurgisk behandling af levertumorer hos børn

    DEFF Research Database (Denmark)

    Rasmussen, Allan; Kvist, Nina; Kirkegaard, Preben

    2008-01-01

    INTRODUCTION: In this paper we review the results of surgical treatment of children with hepatic tumours. MATERIALS AND METHODS: The study comprises 33 children who have undergone lever resection or liver transplantation since 1990. 26 patients had hepatoblastoma, 3 had hepatocellular carcinoma, 2...... had rhabdomyosarcoma, 1 had a mesenchymal tumour, and 1 had a giant haemangioma. RESULTS: Because of the number of patients, we only analyzed the results of the treatment in the hepatoblastoma group. The survival was the same after resection (77.3%) and liver transplantation (75...

  3. Dysfunktionel vejrtrækning hos patienter med astma

    DEFF Research Database (Denmark)

    Andreasson, Karen Hjerrild; Skou, Søren T; Porsbjerg, Celeste

    2017-01-01

    Dysfunctional breathing (DB) is a common comorbidity in adults with incomplete asthma control. The few available large-scale, randomized studies suggest efficacy of physiotherapy on symptom burden. In this article we discuss the current evidence including the need for systematic description...

  4. Emosjonsregulering og motivasjon hos barn med AD/HD

    DEFF Research Database (Denmark)

    Høvik, Marie Farstad; Plessen, Kerstin J

    2010-01-01

    Impaired cognitive control functions have long been regarded as the main problem in the development of Attention-Deficit/Hyperactivity Disorder (ADHD). A more recent model emphasizes the importance of emotional and motivational problems. We have reviewed the evidence for this model, which may have...... important implications for clinical practice....

  5. Peritoneal tuberkulose hos patient med formodet dissemineret ovariecancer

    DEFF Research Database (Denmark)

    Madsen, Lone Wulff; Neumann, Gudrun; Pedersen, Court

    2012-01-01

    imaging) supported this suspicion. Peritoneal biopsy from laparoscopy showed granulomas with central necrosis. Microscopy, culture and polymerase chain reaction from biopsy samples were negative for Mycobacterium tuberculosis. Follow-up with a CT scan after six months of full tuberculosis treatment showed...... normal conditions. Peritoneal tuberculosis is a diagnostic challenge, but should be considered in case of immigrants from high-risk areas....

  6. Lean hos masskundanpassande producenter : Att masskundanpassa produkter effektivt

    OpenAIRE

    Makdisi, Jacob; Suddek, Nawras

    2016-01-01

    Massproduktion har varit viktigt för producerande företag genom många decennier. Massproduktionär förmågan att kunna producera och erbjuda stora volymer till låga priser. Utvecklingenav kunders efterfrågan har däremot den senaste tiden gått mot kundanpassade produkter. Priset förväntas ligga på samma nivå som massproducerade produkter. Utmaningen förföretagen är att kunna massproducera samtidigt som kunders varierande behov tillgodoses. Kundanpassning innebär att produkter utformas och produc...

  7. Forbedret overlevelse hos børn med neuroblastom

    DEFF Research Database (Denmark)

    Schrøder, Henrik; Wacher, Jeanette; Larsson, Heidi

    2010-01-01

    children below 15 years of age with neuroblastoma or ganglioneuroblastoma who were diagnosed in Denmark between 1981 and 2005. RESULTS: The incidence was 8.68 per million children below 15 years of age (world standard 9.6) and 43.5 per million children below 12 months of age and these incidences have...... three years from diagnosis occurred in only 2% of patients. The median time from relapse to death was three months. CONCLUSION: The survival of children with neuroblastoma in Denmark has increased significantly over the last 25 years. Udgivelsesdato: 2010-Oct-4...

  8. Progressiv multifokal leukoencefalopati hos en patient med myelomatose

    DEFF Research Database (Denmark)

    Willert, Cecilie Balslev; Engsig, Frederik Neess; Eskildsen, Helle Wulf

    2015-01-01

    Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease in the central nervous system. It is caused by reactivation of John Cunningham-virus and has a grave prognosis. PML occurs most frequently in HIV-patients, but can also be seen in patients with iatrogenic...

  9. Pyomyositis uden feber hos 12-årig pige

    DEFF Research Database (Denmark)

    Maagaard, Mathilde; Hindsø, Klaus; Wislander, Steen Bo

    2009-01-01

    resonance imaging (MRI) revealed infection in the left m. ileopsoas. Previous ultrasound, computerised tomography, x-ray and bone-scintigraphy were normal. After 11 days of intravenous antibiotic therapy and clinical remission, secondary bone affection was detected by a new MRI. Long-term antibiotic...... treatment is required in such cases because of the risk of secondary bone affection. This patient was treated for 11 days with intravenous antibiotic therapy and for the subsequent three months with tablets. Udgivelsesdato: 2009-Mar-2...

  10. Infektionsrisikoen hos internationale adoptivbørn er reel

    DEFF Research Database (Denmark)

    Pedersen, Tine Marie; Poulsen, Anja; Pedersen, Freddy Karup

    2013-01-01

    -27% have gastrointestinal parasites and 1-7% have tuberculosis, but 3-21% have a positive Mantoux test. The studies found none with HIV or HCV and only a few with syphilis. The vaccination status was often deficient and the serology results did not match the vaccination records. All studies conclude...

  11. Cirkulatorisk kollaps hos bodybuilder i forbindelse med anaestesi

    DEFF Research Database (Denmark)

    Ravn, Toke; Afshari, Arash; Nielsen, Jeppe Sylvest

    2010-01-01

    The use of anabolic steroids is a growing problem in Denmark. The effects and side effects caused by anabolic steroids in relation to anaesthesia are poorly described. This article describes a case of circulatory collapse in a young bodybuilder during anaesthesia. The primary cause of the collapse...

  12. Behandling af kroniske sygdomme hos patienter med demens

    DEFF Research Database (Denmark)

    Pedersen, Hanne; Klinkby, Kristian Skikkild; Waldorff, Frans Borch

    2017-01-01

    , polypharmacy and chronic pain. Ongoing goal setting is important, and advance care planning is recommended. In general, comorbidity must be carefully and holistic assessed and managed according to each patient's general status of health and stage of dementia. As the dementia develops, focus should primarily...

  13. Ornitoserisiko hos ansatte i Københavns Zoologiske Have

    DEFF Research Database (Denmark)

    Christensen, A L; Jarløv, J O; Ingeberg, S

    1990-01-01

    Because a keeper in Copenhagen ZOO had developed ornithosis, clinical and serological examination of the staff of the ZOO was instituted. The object was to demonstrate any possible threatening epidemic and also to demonstrate if the staff of the ZOO were particularly exposed to the risk of ornith...... of ornithosis. Neither of these could be confirmed....

  14. Does Seeing the Doctor More Often Keep You Out of the Hospital?

    OpenAIRE

    Robert Kaestner; Anthony T. Lo Sasso

    2012-01-01

    By exploiting a unique health insurance benefit design, we provide novel evidence on the causal association between outpatient and inpatient care. Our results indicate that greater outpatient spending was associated with more hospital admissions: a $100 increase in outpatient spending was associated with a 2.7% increase in the probability of having an inpatient event and a 4.6% increase in inpatient spending among enrollees in our sample. Moreover, we present evidence that the increase in hos...

  15. Den Gode Historie

    DEFF Research Database (Denmark)

    Mogensen, T.E.

    den nysgerrige læser af trilogien. Den kan beses og bestilles på: www.universitypress.dk/DK/detail.php?token=73278292116&R=8778387078&N=nej ELLER KØB DEN DIREKTE HOS MIG: SLAGTILBUD 100 kr. (inkl. porto og forsendelse)!                            Henvendelse pr. e-mail til tine.engel@gmail.com...

  16. Incidence and seasonality of falls amongst old people receiving home help services in a municipality in northern Sweden

    OpenAIRE

    Vikman, Irene; Nordlund, Anders; Näslund, Annika; Nyberg, Lars

    2011-01-01

    Artikkelen omhandler en studie hvor hensikten var å undersøke forekomst, inkludert variasjoner ad sesonger, omstendigheter og skader relatert til fall hos eldre som bor hjemme og mottar hjemmesykepleie, samt undersøke om det er en sammenheng mellom fall og type/omfang hjelp fra hjemmesykepleien. Objectives: falls among old people is a well-documented phenomenon; however, falls among people living in the community and receiving home help services have been under-researched. The aim of this ...

  17. Health care workers indicate ill preparedness for Ebola Virus Disease outbreak in Ashanti Region of Ghana

    OpenAIRE

    Augustina Angelina Annan; Denis Dekugmen Yar; Michael Owusu; Eno Akua Biney; Paa Kobina Forson; Portia Boakye Okyere; Akosua Adumea Gyimah; Ellis Owusu-Dabo

    2017-01-01

    Abstract Background The recent Ebola Virus Disease (EVD) epidemic that hit some countries in West Africa underscores the need to train front line high-risk health workers on disease prevention skills. Although Ghana did not record (and is yet to) any case, and several health workers have received numerous training schemes, there is no record of any study that assessed preparedness of healthcare workers (HCWS) regarding EVD and any emergency prone disease in Ghana. We therefore conducted a hos...

  18. Etikk i anvendt idrettspsykologi: en kvalitativ studie av idrettspsykologiske rådgiveres etiske utfordringer i anvendt idrettspsykologi, og håndtering av disse

    OpenAIRE

    Ulltang, Espen

    2015-01-01

    Masteroppgave - Norges idrettshøgskole, 2015 Idrettspsykologi er et fag som arbeider for å utvikle mentale ferdigheter hos utøvere og trenere. De som arbeider med anvendt idrettspsykologi møter en rekke etiske utfordringer i sin praksis, men kunnskap om dette synes mangelfullt i Norge. Internasjonalt er det publisert en rekke essays, artikler, og bøker om etiske utfordringer i anvendelsen av faget, men ingen studier viser hvordan norske idrettspsykologiske rådgivere opplever sl...

  19. Hvordan kan fosterbarns indre arbeidsmodeller positivt påvirkes i relasjon med nære omsorgspersoner? Knyttet opp mot SIP-modellen (Sosial informasjonsprosesserings-modell)

    OpenAIRE

    Sunde, Gunn Karin

    2014-01-01

    Master's thesis in Special education Sammendrag Det er stadig flere barn som har behov for å bli omplassert i fosterhjem (Aleris, 2012), grunnet bl.a. omsorgssvikt og utrygg tilknytning (Anke, 2007). Det vil ha innflytelse på fosterbarns indre arbeidsmodeller, som er integrerte mønster hos barnet basert på erfaringer fra samspillet med tilknytningspersonene (Bowlby, 1994). SIP-modellen gir kunnskap om barns mentale prosesser og sosiale tilpasning, og viser mulighet for modifisering av f...

  20. Barns opplevelse av postoperativ smerte og smertebehandling

    OpenAIRE

    Næss, Torgun

    2016-01-01

    Master i intensivsykepleie Bakgrunn: Postoperativ smerte hos barn er underbehandlet til tross for mye smerteforskning. Ulike studier har vist at barn opplever moderat til sterk smerte postoperativt. Ubehandlet smerte kan skape unødvendig lidelse for barn og øker risiko for komplikasjoner. Hensikt: Det finnes ingen forskning på norske barns opplevelse av postoperativ smerte og smertebehandling. Studiens hensikt er å få en større forståelse for hvordan barn opplever postoperativ smerte og sm...