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Sample records for legitimate anti-aging studies

  1. International New Venture Legitimation: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Romeo V. Turcan

    2013-11-01

    Full Text Available There is limited theoretical understanding and empirical evidence for how international new ventures legitimate. Drawing from legitimation theory, this study fills in this gap by exploring how international new ventures legitimate and strive for survival in the face of critical events during the process of their emergence. It is a longitudinal, multiple-case study research that employs critical incident technique for data collection, analysis, and interpretation. Following theory driven sampling, five international new ventures were selected that were operating in the software sector in the UK, and had internationalized and struggled for survival during the dotcom era. Grounded in data, this study corroborates a number of legitimation strategies yielded by prior research and refutes others. It further contributes to our understanding of international new venture legitimation by suggesting new types of legitimation strategies: technology, operating, and anchoring. Studying international new ventures through theoretical lenses of legitimation is a promising area of research that would contribute to the advancement of international entrepreneurship theory.

  2. An Ethnographic Study of New Venture and New Sector Legitimation

    DEFF Research Database (Denmark)

    Turcan, Romeo V.; Fraser, Norman

    2016-01-01

    This study explores the process of legitimation of international new ventures from an emerging economy and the effect such ventures have on the process of creation and legitimation of a new industry in that economy. It is a longitudinal ethnographic case study. Following an inductive theory...... not exist to a final condition in which it is institutionalized. The model addresses the case where the initial catalyst is the formation of an international new venture that is the seed for the birth of the industry. Since both the new venture and the new industry lack cognitive and socio...... building approach, data were collected over an eleven year period via in-depth interviews, participant observations, and unobtrusive data. The study puts forward a process model of new industry legitimation. The model theorizes the process of change from an initial condition in which an industry does...

  3. Empirical Studies on Legitimation Strategies: A Case for International Business Research Extension

    DEFF Research Database (Denmark)

    Turcan, Romeo V.; Marinova, Svetla Trifonova; Rana, Mohammad Bakhtiar

    2012-01-01

    The paper focuses on legitimation and legitimation strategies applied by companies. Following the process of systematic review, we analyze empirical studies exploring legitimation and legitimation strategies from different theoretical perspectives. Using the key findings by reconnoitering and com...... and comparing the theoretical background, approaches, methodologies, and findings of these empirical studies, we outline potential directions for research in the legitimation strategies of firms engaged in international business operations....

  4. Hormesis-based anti-aging products: a case study of a novel cosmetic

    DEFF Research Database (Denmark)

    Rattan, Suresh; Kryzch, Valerie; Schnebert, Sylvianne

    2013-01-01

    and cosmeceuticals. Here we present the example of a skin care cosmetic as one of the first successful product developments incorporating the ideas of hormesis. This was based on the studies to analyse the molecular effects of active ingredients extracted from the roots of the Chinese herb Sanchi (Panax notoginseng...... in reducing the age-related accumulation of molecular damage. For example, repeated heat stress-induced synthesis of heat shock proteins has been shown to have a variety of anti-aging effects on growth and other cellular and biochemical characteristics of normal human skin fibroblasts, keratinocytes...... and endothelial cells undergoing aging in vitro. Therefore, searching for potential hormetins – conditions and compounds eliciting SR-mediated hormesis – is drawing attention of not only the researchers but also the industry involved in developing healthcare products, including nutriceuticals, functional foods...

  5. Art and technology: A comparative study of policy legitimation

    NARCIS (Netherlands)

    N.M. Wijnberg (Nachoem)

    1994-01-01

    textabstractThe legitimation of technology policy is discussed from the point of view of the neoclassical and of the dynamic, Schumpeterian, approach. The results are presented, using the traditional categories of policy legitimation in welfare theory: public goods, externalities, and merit goods.

  6. Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study.

    Science.gov (United States)

    Garre, Aurora; Martinez-Masana, Gemma; Piquero-Casals, Jaime; Granger, Corinne

    2017-01-01

    Skin aging is accelerated by multiple extrinsic factors: ultraviolet radiation, smoking and pollution increase oxidative activity, damaging cellular and extracellular components such as DNA, proteins, and lipids. With age, collagen and hyaluronic acid levels decline, resulting in loss of elasticity and moisture of the skin. Over time this damage leads to characteristic signs that make the skin look older: altered facial contour, sagging skin, wrinkles, and an uneven complexion. This study evaluated the anti-aging effects of a new facial cream formulated with carnosine, Alteromonas ferment extract, crosspolymer hyaluronic acid, and a tripeptide. An open-label intra-individual study to assess the anti-aging efficacy of the investigational product in 33 women aged 45 to 65 years. The product was applied twice daily for 56 days. Facial contour and skin deformation, elasticity, hydration, and complexion were measured with specialized equipment at baseline and days 28 and 56. Additionally, subjects completed questionnaires at days 28 and 56 on the perceived efficacy and cosmetic characteristics of the product. After 56 days of use of the investigational product, a redefining effect was observed, with a significant decrease in sagging jawline (7%). Skin was significantly more hydrated (12%), firmer (29%), and more elastic (20%) ( P <0.001 for all). On complexion assessment, skin texture (a measure of skin smoothness) and spots (brown and red skin lesions) also improved significantly (12% and 6% decrease, respectively). In the subjective self-evaluation, the majority of subjects reported that the skin was visibly tightened and more elastic, flexible, and moisturized (91%, 88%, 91%, and 90%, respectively). The product was well tolerated with no adverse events reported during the study. This new cosmetic product demonstrated anti-aging effects after 56 days of use, most notably a redefined facial contour and improved complexion. It is a safe and effective anti-aging product.

  7. Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study

    Directory of Open Access Journals (Sweden)

    Garre A

    2017-11-01

    Full Text Available Aurora Garre,1 Gemma Martinez-Masana,1 Jaime Piquero-Casals,2 Corinne Granger1 1Innovation and Development, ISDIN S.A., Barcelona, Spain; 2Dermik Clinic, Barcelona, Spain Background: Skin aging is accelerated by multiple extrinsic factors: ultraviolet radiation, smoking and pollution increase oxidative activity, damaging cellular and extracellular components such as DNA, proteins, and lipids. With age, collagen and hyaluronic acid levels decline, resulting in loss of elasticity and moisture of the skin. Over time this damage leads to characteristic signs that make the skin look older: altered facial contour, sagging skin, wrinkles, and an uneven complexion. This study evaluated the anti-aging effects of a new facial cream formulated with carnosine, Alteromonas ferment extract, crosspolymer hyaluronic acid, and a tripeptide. Methods: An open-label intra-individual study to assess the anti-aging efficacy of the investigational product in 33 women aged 45 to 65 years. The product was applied twice daily for 56 days. Facial contour and skin deformation, elasticity, hydration, and complexion were measured with specialized equipment at baseline and days 28 and 56. Additionally, subjects completed questionnaires at days 28 and 56 on the perceived efficacy and cosmetic characteristics of the product. Results: After 56 days of use of the investigational product, a redefining effect was observed, with a significant decrease in sagging jawline (7%. Skin was significantly more hydrated (12%, firmer (29%, and more elastic (20% (P<0.001 for all. On complexion assessment, skin texture (a measure of skin smoothness and spots (brown and red skin lesions also improved significantly (12% and 6% decrease, respectively. In the subjective self-evaluation, the majority of subjects reported that the skin was visibly tightened and more elastic, flexible, and moisturized (91%, 88%, 91%, and 90%, respectively. The product was well tolerated with no adverse events reported

  8. [A preliminary study of anti-aging and wound healing of recombination cytoglobin].

    Science.gov (United States)

    Li, Zhao-Fa; Zhao, Xiao-Fang; Zhang, Ting-Ting

    2012-01-01

    In this paper, the preliminary study on antioxidant, enhancement of antioxidant enzymes activity, reducing the content of oxygen free radicals, delaying skin aging of the recombination cytoglobin (rCygb) purified by our lab were investigated through human keratinocyte cell line (HaCAT) H2O2 oxidative stress model, mouse skin aging model caused by continuous subcutaneous injection D-gal, rat acute liver injury model induced by CCl4 and rat skin wound healing model. The results showed that rCygb improved the activities of total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), reduced the activities of lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) as well as decreased the content of malondialdehyde (MDA). Skin biopsy showed that rCygb promoted angiogenesis, increased expression of collagen and improved the anti-inflammatory ability. All results displayed that rCygb improved the oxygen free radical scavenging ability, delayed skin aging and promoted wound healing.

  9. International New Venture Legitimation

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2013-01-01

    There is limited theoretical understanding and empirical evidence for how international new ventures legitimate. Drawing from legitimation theory, this study fills in this gap by exploring how international new ventures legitimate and strive for survival in the face of critical events during...... the process of their emergence. It is a longitudinal, multiple-case study research that employs critical incident technique for data collection, analysis and interpretation. Following theory driven sampling, five international new ventures were selected that were operating in the software sector in the UK...... types of legitimation strategies: technology, operating, and anchoring. Studying international new ventures through theoretical lenses of legitimation is a promising area of research that would contribute to the advancement of international entrepreneurship theory....

  10. UNIVERSITY, RELIGION AND THE COMPANIES: A STUDY OF RELIGIOUS LEGITIMATION LOGIC OF CAPITAL IN HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    Evandro Ricardo Guindani

    2014-06-01

    Full Text Available This work results from a study at the doctoral level who investigated how the university helps to legitimize the logic of capital, through research in religious studies. Seven dissertations produced in two Brazilian universities were analyzed. While focusing on the creation of this issue today, we have not lost sight of how, since the Middle Ages, theology was used by the nobility and the clergy, preceding or current way of announcing the appropriation of this knowledge by the hegemonic class. Detected in the current context or a resumption of the tightening relationship between religion and market mediation University, now no longer in the service of the nobility and the clergy, but of entrepreneurs.

  11. (LBP) extraction technology and its anti-aging effect

    African Journals Online (AJOL)

    The objective of the study was to optimise the LBP extraction technology and to study the anti-aging effect of LBP by establishing D-gal aging mouse model. Orthogonal design was used to study the extraction technology. The experimental aging mouse model was formed by continuous injection of D-gal, and the anti-aging ...

  12. [Anti-ageing therapies in Alzheimer's disease].

    Science.gov (United States)

    Alonso Abreu, Gara S; Brito Armas, José M; Castro Fuentes, Rafael

    Alzheimer's disease is the most common cause of dementia in the elderly population. Currently, there are no effective treatments to prevent or delay the natural course of the disease. Numerous studies have provided information about the molecular processes underlying biological ageing and, perhaps more importantly, potential interventions to slow ageing and promote healthy longevity in laboratory model systems. The main issue addressed in this review is whether an intervention that has anti-ageing properties can alter the appearance and/or progression of Alzheimer's disease, a disease in which age is the biggest risk factor. Different anti-ageing interventions have been shown to prevent (and in some cases possibly restore) several parameters recognised as central symptoms to the development of Alzheimer's disease. In addition, they are taking the first steps towards translating these laboratory discoveries into clinical applications. Copyright © 2017 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved.

  13. [Recent advances in anti-aging study of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside--a main component of Polygonum multiflorum].

    Science.gov (United States)

    Li, Yi-Han; Wang, Yue-Fei; Zhu, Yan

    2016-01-01

    Aging is an inevitable process of life caused by a combination of organs and tissues events which manifests as loss of structure and function. It is accompanied with organ hypofunction, decline in defense against stress and energy metabolism, and lots of age-related diseases. Therefore, it is critical to understand the mechanism of aging, as well as to discover new drugs to slow aging. Polygonum multiflorum has long been recognized in traditional Chinese medicine as anti-aging medicine. Interestingly, its extract has been shown to prolong lifespan in drosophila and elegans. Tetrahydroxystilbene glucoside (TSG), the main ingredient of P. multiflorum, shares a strong structural similarity with resveratrol, a well-known anti-aging natural product. This review summarized up-to-date literature reports and our laboratory findings on the mechanism of TSG anti-aging efficiency and function against age-related disease. It could provide reference for searching for anti-aging tradition Chinese medicine. Copyright© by the Chinese Pharmaceutical Association.

  14. Synthetic drugs with anti-ageing effects.

    Science.gov (United States)

    Kapoor, Vijay K; Dureja, Janhvi; Chadha, Renu

    2009-09-01

    Although ageing is a natural wear and tear phenomenon, it can at least be postponed or prevented by certain approaches. Some chemicals that are present in the diet or in dietary supplements have been documented to have anti-ageing effects. Recently, a number of synthetic drugs used for other therapeutic indications have been shown to have anti-ageing potential.

  15. The Road to Become a Legitimate Scholar: A Case Study of International PhD Students in Science and Engineering

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    Pia Bøgelund

    2015-11-01

    Full Text Available The purpose of the doctoral education process is to create and legitimize scholarly researchers. This transformation, from student to scholar, is widely discussed in the literature. However, recent rapid changes in university culture have resulted in less time for supervision, stricter completion deadlines, and a greater focus on efficiency and productivity. This has had an impact on this transition process, and this impact has not been widely studied. The aim of this article is to understand the consequences of the current trends for PhD students and the education of PhD students in general. The article is based on interviews with 14 international students from two different research programs at the Faculty of Engineering and Science at Aalborg University in Denmark. The case of international PhD students in a western setting is singled out as a challenging case for becoming a legitimate scholar, since they face the additional challenge of becoming socialised into their new foreign setting. Overall, the study concludes that the transition process of doctoral students is affected by the way different supervisors deal with current university trends and how PhD students fit or do not fit into their knowledge production practices. The study identifies matches or mismatches in a knowledge production perspective, quality of contact, and degree of independence of the PhD student as factors that influence whether a transition process can be marked as sound, troublesome, or lacking. Finally, the study identifies an overall risk of neglecting the more interdependent types of international PhD students. Suggestions are given as how to address this risk.

  16. What is an anti-aging treatment?

    Science.gov (United States)

    Gems, David

    2014-10-01

    Key objectives of biogerontology are to understand the biology of aging and to translate scientific insight into interventions that improve late-life health - or anti-aging treatments. In this context, when considering the problem of how to effect translational research, it is useful to have a clear, consensus view on what exactly constitutes an anti-aging treatment. This essay critically assesses the understanding of this concept common among biogerontologists, and proposes a new definition. A current conception of anti-aging treatment imagines a primary cause of aging that is causally upstream of, and the cause of, all age-related pathology. Intervening in this aging process thus protects against the totality of age-related diseases. However, this underlying aging process remains an abstraction. By contrast, what is demonstrable is that interventions in model organisms can improve late-life health and extend lifespan. Furthermore, a safe deduction is that treatments that extend lifespan do so by reducing age-related pathology, both florid and subtle. What is currently identifiable about aging (i.e. senescence) is that it is a very complex disease syndrome, likely involving a number of biological mechanisms. Treatments that substantially extend lifespan must suppress multiple pathologies that otherwise limit lifespan, but whether they suppress the entire aging process remains undemonstrated. A more pragmatic and realistic definition of anti-aging treatment is any preventative approach to reduce late-life pathology, based on the understanding that senescence is a disease syndrome. This definition would encompass preventative approaches aimed at both broad and narrow spectra of age-related pathologies. Its adoption would facilitate translation, since it would shift the emphasis to medical practice, particularly the introduction of preventative approaches. Narrow spectrum anti-aging treatments (e.g. the cardiovascular polypill) could establish a practice that

  17. Anti-Aging Drugs - Prospect of Longer Life?

    Science.gov (United States)

    Klimova, Blanka; Novotny, Michal; Kuca, Kamil

    2017-11-29

    Aging is a natural part of human life. However, recent discoveries indicate that pharmacological approaches used for the improvement and possibly, for the delay of the aging process, might shed a new light on this topic. This might obviously contribute to the extension of the active life of older people and maintenance of their quality of life, which could consequently reduce both social and economic burden of each country, especially the developed ones. The purpose of this study is to explore pharmacological discoveries which may help to the delay or improvement of the aging process. More specifically, the authors focus on three anti-aging drugs candidates: metformin, rapamycin and resveratrol and one anti-aging component NAD+ precursors whose randomized control trials on animals have appeared to provide some efficacy in this respect and they seem to be promising in the aging process of human beings. This was done by conducting a literature review of available sources describing the issue of aging process with special focus on those anti-aging drug candidates. The results of this study indicate that promising anti-aging candidates seem to be metformin, especially as far as cardiovascular or cancer mortality is concerned, and NAD+ precursors since they appear to promote better organ function, increased physical resistance, disease resistance and prolonged life expectancy. There is a call for more longitudinal clinical trials, which would prove the efficacy of the promising anti-aging drugs candidates in humans. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  18. Keys to the Community : A multiple case study into professional legitimation in community development practice

    NARCIS (Netherlands)

    Gradener, Jeroen

    2016-01-01

    This study examines how community development professionals obtain a sense of legitimacy in their work with local communities. In a comparative study derived from field research in Chelsea (USA), Amsterdam (The Netherlands ) and Doornkop (South Africa) the building blocks of their sense of

  19. A Case Study of Legitimate Literacies: Teens' "Small World" and the School Library

    Science.gov (United States)

    Comstock, Sharon L.

    2012-01-01

    This dissertation is a dual-site ethnographic case study of the lived information literacy experiences of students in their junior year of high school relative to their school library and librarians. What began as an investigation of an apparent gap in understanding between the views of teens and school librarians regarding "information…

  20. Visible, Legitimate, and Beautiful Justice: A Case Study of Music Education Formalization within a Haitian NGO

    Science.gov (United States)

    Shorner-Johnson, Kevin

    2017-01-01

    When music education is formalized within schools and non-governmental organizations, it often becomes aligned with justice-oriented aims of providing universal access to music education. This qualitative case study examines the formation of a marching band within a Haitian school in northeastern Haiti. Data sources collected and analyzed included…

  1. [Anti-aging medicine, a science-based, essential medicine].

    Science.gov (United States)

    Hertoghe, T; Lhermitte, M C; Poutet, B; Godefroit, C; Privé, D; Baneth, E; Everard, B; Hertoghe, T; Guery, G; Gadomski, A; Walraevens, A; Résimont, S; Wechoko, L; Seny, E; Vollon, K; Claeys, B

    2015-01-01

    Anti-aging medicine is booming. It enters more and more in the programs of universities. Its hormone and nutritional tests and therapies rely on numerous scientific studies, including double-blind placebo-controlled randomized studies. Its methods are often innovative to obtain more information or benefits with greater safety. The fundamental purpose of anti-aging medicine is to optimize health and the quality of life, and through this, make the physical appearance more youthful. Well-chosen and well-dosed these treatments should not increase the risk of age-related diseases such as cancer and cardiovascular diseases, but on the contrary decrease it by the preventive aspect of the treatments. Opponents to anti-aging medicine fail in collecting valid scientific arguments. Their insistence on maintaining a society of elderly people looking and feeling as elderly people rather than actively participating in searching for ways to attenuate aging is harmful to all who follow them, to themselves in the first place.

  2. Anti-Ageing Cultures, Biopolitics and Globalisation

    Directory of Open Access Journals (Sweden)

    Brett Neilson

    2011-11-01

    Full Text Available In March 2004, the author attended the Inaugural International Conference on Longevity at the Sydney Exhibition and Convention Centre in Darling Harbour. As a cultural researcher interested in the interactions between demographic shifts, capitalist globalisation and changing forms of political power, the prospect of a direct encounter with the debates and practices surrounding the burgeoning field of anti-ageing medicine promised a means to observe the complex cultural dynamics of population ageing at play. This article explores the discord the atuhor witnessed; a quarrel that, despite the march of technological advance, attests the ongoing conflict in the nexus where politics meets life.

  3. Physicochemical characterization of native glycyl-l-histidyl-l-lysine tripeptide for wound healing and anti-aging: a preformulation study for dermal delivery.

    Science.gov (United States)

    Badenhorst, Travis; Svirskis, Darren; Wu, Zimei

    2016-03-01

    This study investigates the physicochemical properties of glycyl-histidyl-lysine-copper (GHK-Cu) to support the development of a formulation for effective topical delivery. The solubility and distribution coefficients (log D) were investigated using conventional methods and GHK concentrations were quantified with a validated stability-indicating reversed phase high performance liquid chromatography (RP-HPLC) method. In addition, the stability of GHK-Cu under stressed conditions and the compatibility with some potential formulation components were assessed. The peptide was susceptible to hydrolytic cleavage under basic and oxidative stressors and to a lesser extent acidic stress with first-order degradation profiles. Surprisingly, the peptide was stable in water and in pH (4.5-7.4) buffers for at least two weeks at 60  °C. The HPLC in conjunction with mass spectrometry identified three key degradation products, one of which was the constituent amino acid histidine. The distribution coefficients in octanol-phosphate buffered saline indicated the highly hydrophilic nature of GHK-Cu with log D values between -2.38 and -2.49 at pH range of 4.5-7.4. Furthermore, GHK-Cu was compatible with Span 60 based niosomes but less stable in the presence of the negatively charged lipid dicetyl phosphate. In summary, the preformulation studies provided information useful to deliver the GHK-Cu complex by carrier.

  4. A nutrigenomics approach for the study of anti-aging interventions: olive oil phenols and the modulation of gene and microRNA expression profiles in mouse brain.

    Science.gov (United States)

    Luceri, Cristina; Bigagli, Elisabetta; Pitozzi, Vanessa; Giovannelli, Lisa

    2017-03-01

    Middle-aged C57Bl/6J mice fed for 6 months with extra-virgin olive oil rich in phenols (H-EVOO, phenol dose/day: 6 mg/kg) showed cognitive and motor improvement compared to controls fed the same olive oil deprived of phenolics (L-EVOO). The aim of the present study was to evaluate whether these behavioral modifications were associated with changes in gene and miRNA expression in the brain. Two brain areas involved in cognitive and motor processes were chosen: cortex and cerebellum. Gene and miRNA profiling were analyzed by microarray and correlated with performance in behavioral tests. After 6 months, most of the gene expression changes were restricted to the cerebral cortex. The genes modulated by aging were mainly down-regulated, and the treatment with H-EVOO was associated with a significant up-regulation of genes compared to L-EVOO. Among those, we found genes previously associated with synaptic plasticity and with motor and cognitive behavior, such as Notch1, BMPs, NGFR, GLP1R and CRTC3. The agrin pathway was also significantly modulated. miRNAs were mostly up-regulated in old L-EVOO animals compared to young. However, H-EVOO-fed mice cortex displayed miRNA expression profiles similar to those observed in young mice. Sixty-three miRNAs, out of 1203 analyzed, were significantly down-regulated compared to the L-EVOO group; among them, we found miRNAs whose predicted target genes were up-regulated by the treatment, such as mir-484, mir-27, mir-137, mir-30, mir-34 and mir-124. We are among the first to report that a dietary intervention starting from middle age with food rich in phenols can modulate at the central level the expression of genes and miRNAs involved in neuronal function and synaptic plasticity, along with cognitive, motor and emotional behavior.

  5. The Legitimation of Violence

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    Geraldo Miniuci

    2012-09-01

    Full Text Available This text is oriented by the following questions: What is terrorism? How does it differ from other legitimized violent acts committed during war or in the course of a revolution? In order to answer them, this article discusses, first, the legitimacy of violence and the moral judgment of it; second, it will address the distinction between terrorist acts, acts of war, common crimes and revolutionary action, on the one hand, and the concept of innocent victim and the legitimacy of the target, on the other. In short, a new classification for terrorism will be seen, which will appear as a tactic used by political groups, as well as by public authorities, in the course of a revolution or during a war.

  6. Legitimizing Blacks in Philosophy

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    Jameliah Shorter-Bourhanou

    2017-12-01

    Full Text Available In its efforts toward improving diversity, the discipline of philosophy has tended to focus on increasing the number of black philosophers. One crucial issue that has received less attention is the extent to which black philosophers are delegitimized in the discipline because their philosophical contributions challenge the status quo. A systematic problem that bars black philosophers from equal and full participation, this delegitimization precludes the emergence of genuine diversity and reveals the importance of interrogating broader attitudes toward black philosophical contributions. In this essay, I argue for radical systematic changes to disciplinary hallmarks of professionalization such as pedagogy, mentoring, publishing, and hiring practices with the aim of legitimizing black philosophers and their contributions.

  7. Chemical composition, antioxidant and anti-AGEs activities of a French poplar type propolis.

    Science.gov (United States)

    Boisard, Séverine; Le Ray, Anne-Marie; Gatto, Julia; Aumond, Marie-Christine; Blanchard, Patricia; Derbré, Séverine; Flurin, Catherine; Richomme, Pascal

    2014-02-12

    Accumulation in tissues and serum of advanced glycation end-products (AGEs) plays an important role in pathologies such as Alzheimer's disease or, in the event of complications of diabetes, atherosclerosis or renal failure. Therefore, there is a potential therapeutic interest in compounds able to lower intra and extracellular levels of AGEs. Among them, natural antioxidants (AO) with true anti-AGEs capabilities would represent good candidates for development. The purpose of this study was to evaluate the AO and anti-AGEs potential of a propolis batch and then to identify the main compounds responsible for these effects. In vivo, protein glycation and oxidative stress are closely related. Thus, AO and antiglycation activities were evaluated using both DPPH and ORAC assays, respectively, as well as a newly developed automated anti-AGEs test. Several propolis extracts exhibited very good AO and anti-AGEs activities, and a bioguided fractionation allowed us to identify pinobanksin-3-acetate as the most active component.

  8. Assessment of a Comprehensive Anti-Aging Neck Cream.

    Science.gov (United States)

    Saxena, Subhash J; Duque, Deysi; Schirripa, Michael J

    2015-09-01

    With many effective anti-aging solutions for the face, consumer focus is now turning to other parts of the body including the delicate skin on the neck. This study investigates the effect of a new neck cream on the appearance of texture, fine lines and wrinkles, laxity, and hydration. 85 adult females ages 35-65 with Fitzpatrick skin types I through IV applied the test neck cream twice daily for a 3-month study period. Screening was conducted at Baseline, 2, 30, 60, and 90 days via a virtual trial. Subjects rated satisfaction in each of 4 anti-aging categories including hydration, texture, appearance of wrinkles, and appearance of laxity as well as three product attributes including application, feel, and smell. Improvement was statistically significant for all measured categories (hydration, texture, appearance of wrinkles, and appearance of laxity) with 94% of study subjects noting improvement in one or more of the measured categories. Further, the quantity of "Satisfied" and "Highly Satisfied" assessments increased 8-fold from baseline with a 94x increase in the quantity of "Highly Satisfied" assessments. The results demonstrate the product's rapid and continuing ability to improve the self-perceived signs of aging in the neck area including improvement in skin texture on the neck and a reduction in the appearance of wrinkles and laxity along the jawline. Future studies are recommended to determine the primary action mechanisms and to assess the degree of improvement by blinded physician assessment.

  9. Legitimation in Discourse and Communication

    DEFF Research Database (Denmark)

    van Leeuwen, Theo

    2013-01-01

    , and of persons in whom institutional authority is vested, (2) moral evaluation, legitimation by reference to discourses of value, (3) rationalization, legitimation by reference to the goals and uses of institutionalized social action and to the social knowledges that endow them with cognitive validity, and (4...

  10. A study of the activity and effectiveness of recombinant fibroblast growth factor (Q40P/S47I/H93G rFGF-1) in anti-aging treatment.

    Science.gov (United States)

    Żerańska, Justyna; Pasikowska, Monika; Szczepanik, Barbara; Mlosek, Krzysztof; Malinowska, Sylwia; Dębowska, Renata M; Eris, Irena

    2016-02-01

    Fibroblast growth factor 1 (FGF-1) is a powerful mitogen involved in the stimulation of DNA synthesis and the proliferation of a wide variety of cell types. Fibroblast growth factor 1 was genetically modified to improve its thermal stability and resistance to protease degradation without losing its biological activity. To study the impact of Q40P/S47I/H93G rFGF-1 on skin cells, its penetration through the skin and the evaluation of the rFGF-1-cosmetic product properties. In vitro studies included the examination of primary fibroblast and keratinocyte viability after the incubation with rFGF-1. The penetration abilities of rFGF-1 in various formulations and carrier systems were examined ex vivo by the Raman spectroscopy. In vivo studies - HF Ultrasound and 3D Imaging System - were used to evaluate the anti-aging properties of creams containing rFGF-1. In vitro studies demonstrated that rFGF-1 strongly enhanced the viability of the treated cells. The Raman Spectroscopy analysis indicated that rFGF-1 encapsulated in lipid spheres penetrate through the stratum corneum to the depth of 60 µm, and added to the o/w formulation - could penetrate to a depth of 90 µm. The results obtained from Primos revealed the reduction of the volume and the depth of the wrinkles. Changes in the skin structure in the analyzed areas were evaluated by HF Ultrasonography. Recombinant FGF-1 strongly stimulated fibroblast and keratinocyte proliferation. However, the transition of this protein through the SC required an appropriate carrier system - lipid spheres. All tests - in vitro, ex vivo and in vivo - have proved that rFGF-1 is a substance with a potentially wide spectrum of use.

  11. A study of the activity and effectiveness of recombinant fibroblast growth factor (Q40P/S47I/H93G rFGF-1 in anti-aging treatment

    Directory of Open Access Journals (Sweden)

    Justyna Żerańska

    2016-02-01

    Full Text Available Introduction : Fibroblast growth factor 1 (FGF-1 is a powerful mitogen involved in the stimulation of DNA synthesis and the proliferation of a wide variety of cell types. Fibroblast growth factor 1 was genetically modified to improve its thermal stability and resistance to protease degradation without losing its biological activity. Aim : To study the impact of Q40P/S47I/H93G rFGF-1 on skin cells, its penetration through the skin and the evaluation of the rFGF-1-cosmetic product properties. Material and methods : In vitro studies included the examination of primary fibroblast and keratinocyte viability after the incubation with rFGF-1. The penetration abilities of rFGF-1 in various formulations and carrier systems were examined ex vivo by the Raman spectroscopy. In vivo studies – HF Ultrasound and 3D Imaging System – were used to evaluate the anti-aging properties of creams containing rFGF-1. Results : In vitro studies demonstrated that rFGF-1 strongly enhanced the viability of the treated cells. The Raman Spectroscopy analysis indicated that rFGF-1 encapsulated in lipid spheres penetrate through the stratum corneum to the depth of 60 μm, and added to the o/w formulation – could penetrate to a depth of 90 μm. The results obtained from Primos revealed the reduction of the volume and the depth of the wrinkles. Changes in the skin structure in the analyzed areas were evaluated by HF Ultrasonography. Conclusions : Recombinant FGF-1 strongly stimulated fibroblast and keratinocyte proliferation. However, the transition of this protein through the SC required an appropriate carrier system – lipid spheres. All tests – in vitro , ex vivo and in vivo – have proved that rFGF-1 is a substance with a potentially wide spectrum of use.

  12. (De)Legitimation at the WTO Dispute Settlement Mechanism

    DEFF Research Database (Denmark)

    Creamer, Cosette; Godzimirska, Zuzanna

    2016-01-01

    ) judicial bodies have relied largely on theoretical or normative priors about what makes these institutions legitimate. In contrast, this paper directly connects the study of courts' legitimating efforts with their effects by empirically mapping how the WTO Dispute Settlement Mechanism's (DSM) exercise......Similar to many types of legal institutions, international courts employ a wide variety of legitimation strategies in order to establish and maintain a sound basis of support among their constituents. Existing studies on the legitimacy or legitimating efforts of the World Trade Organization's (WTO...

  13. Emerging Roles of Ganoderma Lucidum in Anti-Aging

    Science.gov (United States)

    Wang, Jue; Cao, Bin; Zhao, Haiping; Feng, Juan

    2017-01-01

    Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from Ganoderma lucidum, such as Ethanol extract, aqueous extract, mycelia extract, water soluble extract of the culture medium of Ganoderma lucidum mycelia, Ganodermasides A, B, C, D, and some bioactive components of Ganoderma lucidum, including Reishi Polysaccharide Fraction 3, Ganoderma lucidum polysaccharides I, II, III, IV, Ganoderma lucidum peptide, Ganoderma polysaccharide peptide, total G. lucidum triterpenes and Ganoderic acid C1 could exert lifespan elongation or related activities. Although the use of Ganoderma lucidum as an elixir has been around for thousands of years, studies revealing its effect of lifespan extension are only the tip of the iceberg. Besides which, the kinds of extractions or components being comfrimed to be anti-aging are too few compared with the large amounts of Ganoderma lucidum extractions or constituients being discovered. This review aims to lay the ground for fully elucidating the potential mechanisms of Ganoderma lucidum underlying anti-aging effect and its clinical application. PMID:29344411

  14. Emerging Roles of Ganoderma Lucidum in Anti-Aging.

    Science.gov (United States)

    Wang, Jue; Cao, Bin; Zhao, Haiping; Feng, Juan

    2017-12-01

    Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from Ganoderma lucidum , such as Ethanol extract, aqueous extract, mycelia extract, water soluble extract of the culture medium of Ganoderma lucidum mycelia, Ganodermasides A, B, C, D, and some bioactive components of Ganoderma lucidum , including Reishi Polysaccharide Fraction 3, Ganoderma lucidum polysaccharides I, II, III, IV, Ganoderma lucidum peptide, Ganoderma polysaccharide peptide, total G. lucidum triterpenes and Ganoderic acid C1 could exert lifespan elongation or related activities. Although the use of Ganoderma lucidum as an elixir has been around for thousands of years, studies revealing its effect of lifespan extension are only the tip of the iceberg. Besides which, the kinds of extractions or components being comfrimed to be anti-aging are too few compared with the large amounts of Ganoderma lucidum extractions or constituients being discovered. This review aims to lay the ground for fully elucidating the potential mechanisms of Ganoderma lucidum underlying anti-aging effect and its clinical application.

  15. Rice Water: A Traditional Ingredient with Anti-Aging Efficacy

    Directory of Open Access Journals (Sweden)

    Joana Marto

    2018-04-01

    Full Text Available The skin healing benefits of rice have been known for centuries. Rice (Oryza sativa water is a food processing waste that can potentially be incorporated into cosmetic formulations. However, no scientific evidence supports their role in skincare products. The aim of this project is to design and develop a topical gel formulation containing rice water and to evaluate its biological properties, namely, the anti-aging and antioxidant rice water properties. Rice water was evaluated in terms of physico-chemical composition and in terms of in vitro biological antioxidant activity and elastase inhibitory effect. Rice water was incorporated into a hydrogel and the developed formulation was subjected to pharmacotechnical tests such as pH and viscosity. Biological and sensory effects were evaluated on a panel of 12 volunteers for 28 days. The safety evaluation study was performed on rice water gel, using the Human Repeat Insult Patch test protocol. Rice water presented in vitro biological antioxidant activity and elastase inhibitory effect. The gel formulation containing 96% rice water was biocompatible with the human skin and presented suitable cosmetic properties. Rice water should be thus considered as an anti-aging ingredient to be used as raw material for skincare applications.

  16. Legitimating Change in the Public Sector

    DEFF Research Database (Denmark)

    Hyndman, Noel; Liguori, Mariannunziata; Meyer, Renate E.

    2017-01-01

    This paper explores the deployment of rhetorical legitimation strategies during public-sector accounting reforms by investigating how organizational actors justify related changes in the central governments of the United Kingdom (UK), Italy and Austria. The study shows that changes are largely le...... in terms of rationalization and normalization. Italian and Austrian actors more frequently resort to authorization strategies to explain accounting change....

  17. [Screening of anti-aging active ingredients and mechanism analysis based on molecular docking technology].

    Science.gov (United States)

    Du, Ran-Feng; Zhang, Xiao-Hua; Ye, Xiao-Tong; Yu, Wen-Kang; Wang, Yun

    2016-07-01

    Dampness evil is the source of all diseases, which is easy to cause disease and promote aging, while aging could also promote the occurence and development of diseases. In this paper, the relationship between the dampness evil and aging would be discussed, to find the anti-aging active ingredients in traditional Chinese medicine (TCM), and analyze the anti-aging mechanism of dampness eliminating drug. Molecular docking technology was used, with aging-related mammalian target of rapamycin as the docking receptors, and chemical components of Fuling, Sangzhi, Mugua, Yiyiren and Houpo as the docking molecules, to preliminarily screen the anti-aging active ingredients in dampness eliminating drug. Through the comparison with active drugs already on the market (temsirolimus and everolimus), 12 kinds of potential anti-aging active ingredients were found, but their drug gability still needs further study. The docking results showed that various components in the dampness eliminating drug can play anti-aging activities by acting on mammalian target of rapamycin. This result provides a new thought and direction for the method of delaying aging by eliminating dampness. Copyright© by the Chinese Pharmaceutical Association.

  18. A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.

    Science.gov (United States)

    Ladiges, Warren; Snyder, Jessica M; Wilkinson, Erby; Imai, Denise M; Snider, Tim; Ge, Xuan; Ciol, Marcia; Pettan-Brewer, Christina; Pillai, Smitha P S; Morton, John; Quarles, Ellen; Rabinovitch, Peter; Niedernhofer, Laura; Liggitt, Denny

    2017-06-01

    Testing drugs for anti-aging effects has historically been conducted in mouse life-span studies, but are costly and time consuming, and more importantly, difficult to recapitulate in humans. In addition, life-span studies in mice are not well suited to testing drug combinations that target multiple factors involved in aging. Additional paradigms for testing therapeutics aimed at slowing aging are needed. A new paradigm, designated as the Geropathology Grading Platform (GGP), is based on a standardized set of guidelines developed to detect the presence or absence of low-impact histopathological lesions and to determine the level of severity of high-impact lesions in organs from aged mice. The GGP generates a numerical score for each age-related lesion in an organ, summed for total lesions, and averaged over multiple mice to obtain a composite lesion score (CLS). Preliminary studies show that the platform generates CLSs that increase with the age of mice in an organ-dependent manner. The CLSs are sensitive enough to detect changes elicited by interventions that extend mouse life span, and thus help validate the GGP as a novel tool to measure biological aging. While currently optimized for mice, the GGP could be adapted to any preclinical animal model. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  19. Legitimate Allocation of Public Healthcare

    DEFF Research Database (Denmark)

    Lippert-Rasmussen, Kasper; Lauridsen, Sigurd

    2009-01-01

    Citizens' consent to political decisions is often regarded as a necessary condition of political legitimacy. Consequently, legitimate allocation of healthcare has seemed almost unattainable in contemporary pluralistic societies. The problem is that citizens do not agree on any single principle...... governing priorities among groups of patients. The Accountability for Reasonableness (A4R) framework suggests an ingenious solution to this problem of moral disagreement. Rather than advocating any substantive distributive principle, its advocates propose a feasible set of conditions, which, if met...... by decision makers at the institutional level, provide, so it is promised, legitimate decisions. While we agree that A4R represents an important contribution to the priority-setting debate, we challenge the framework in two respects. First, we argue that A4R, and more specifically the relevance condition of A...

  20. Paradigmenwechsel in der Anti-Aging-Medizin: Hormesis, Target-of-Rapamycin-Komplex und erste Anti-Aging-Pillen // Paradigm Shift in Anti-Aging Medicine: Hormesis, Target of Rapamycin Complex and First Human Anti-Aging-Pills

    Directory of Open Access Journals (Sweden)

    Römmler A

    2016-01-01

    Full Text Available Studies in model organisms have shown that some drugs and lifestyle practices (calorie-restricted diets, regular exercise, e.g. can extend life and health span and protect against the onset of age-related chronic diseases by targeting physiological pathways.brA common mode of action was found via mTOR (mechanistic Target Of Rapamycin pathway signalling. This intracellular protein kinase complex plays a key role in stimulating anabolic and cell growth promoting processes, while inhibiting autophagy. On the other hand, downregulation results in antiproliferative, anticancer and intensive cell-repairing effects leading to life and health span extension and stress resistance. The mTOR complex regulates such basic cell activities and integrates signals from nutrition sensing, energy metabolism, insulin and growth factors, stress and hypoxia.brImportantly, mTOR can be inhibited by some molecules and their analogs (rapamycin, resveratrol, metformin, e.g., which are released naturally from plants, yeast or bacteria to protect against natural enemies. Its dosage resembles an adaptive hormetic response relationship, as high concentrations are toxic and mild doses are associated with anticancer and antiaging effects. This opens up new avenues for their use as „anti-aging pills“ in humans.brRecent human data suggest that metformin, rapamycin and other mTOR-inhibitors could delay heart disease, cancer, cognitive decline and improve survival time in people with diabetes mellitus. In addition, response to influenca vaccine was enhanced by rapamycin in adults with immunosenescence, indicating beneficial anti-aging effects in the elderly.br“Treat aging” is an actual call to recognize aging as an indication appropriate for clinical trials and treatments, as it was recently approved by the Federal Drug Administration (FDA USA. p bKurzfassung/b: Die ansteigende Morbidität und Invalidität in alternden Industrienationen stößt an die Grenzen der Ressourcen

  1. Evidence for Anti-Aging South Korean Cosmeceuticals.

    Science.gov (United States)

    Quay, Ellinor R; Chang, Yunyoung C; Graber, Emmy

    2017-04-01

    As the market for South Korean skin care products grows in the U.S. and worldwide, consumers will increasingly seek advice from dermatologists regarding their efficacy. In this paper, the evidence behind the anti-aging and skin whitening activity of ingredients in the most popular South Korean skin care products was reviewed and critically evaluated. Industry profit data from Euromonitor was obtained to identify the top cosmeceutical brands by retail value in South Korea. The top selling products and their ingredients were then identified from individual brand websites. A comprehensive literature search was conducted using Pubmed to identify and grade the anti-aging and whitening efficacy for nine popular ingredients: licorice, niacinamide, beta-glucan, snail mucus, ginkgo biloba, ginseng, green tea, pomegranate, and soy. Of the various ingredients reviewed, niacinamide, green tea, licorice, and soy have the most published data for anti-aging and whitening activity. Although the literature shows modest results, small sample sizes limit interpretation. High-level evidence to support the use of South Korean skin care products in anti-aging and skin whitening is lacking. J Drugs Dermatol. 2017;16(4):358-364..

  2. Linguistic Legitimation of Political Events in Newspaper Discourse

    Directory of Open Access Journals (Sweden)

    Marwah Kareem Ali

    2016-08-01

    Full Text Available This paper examines the discursive structures employed in legitimizing the event of U.S. forces withdrawal from Iraq and identifies them in relation to linguistic features. It attempts to describe the relation between language use and legitimation discursive structures in depicting political events. The paper focuses on the political event of U.S. forces’ withdrawal from Iraq in the English newspaper issued in Iraq. The study shows the way in which journalists express their values and attitudes concerning this critical event. Consequently, this requires a critical discourse analysis (henceforth, CDA to analyse news articles in the Iraqi English newspaper: The Kurdish Globe (henceforth, KG newspaper. Accordingly, the study presents a qualitative content analysis of newspaper articles to identify the legitimation discursive structures and their linguistic features. It is found that the main discursive structures of legitimation employed in the KG newspaper are: authorization, rationalization, and moral evaluation. Besides, there were five verb processes used to represent this legitimation, including material, verbal, relational, mental, and existential. Keywords: Critical discourse analysis, legitimation discursive structures, linguistic features, newspaper discourse, systemic functional linguistics

  3. Legitimate data in remote monitoring.

    Science.gov (United States)

    Schilling, J D

    2009-01-01

    An approach for ensuring legitimate data transfers of an individual within a remote healthcare solution. Biometric traits and networking are discussed for clarification of the approach. In this approach, a biometric solution is identified as a fingerprint scanner for use in a personal area network of the patient's home. Secure data exchange is acknowledged as a potential weakness in the transferring of patient data within this network. Some options are discussed to ensure security of data for the review by the caregiver. Example approaches regarding legitimacy are identified using a pulse oximeter [1], a blood pressure meter, and a weight scale as the remote patient devices in the remote healthcare solution.

  4. External legitimation in international new ventures

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2012-01-01

    building, the paper introduces the typology of captivity, and the four types that have emerged: captive industry supplier, captive dyadic partner, captive market leader, and free market leader. The effects of captivity types on the acquisition of external legitimacy and its survival, on reaching legitimacy......This paper explores within the framework of new venture legitimation how and why international new ventures acquire external legitimacy and strive for survival in the face of critical events. Following a longitudinal multiple-case study methodology that was adopted for the purpose of theory...

  5. Koschei the immortal and anti-aging drugs.

    Science.gov (United States)

    Blagosklonny, M V

    2014-12-04

    In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors.

  6. Selective anti-cancer agents as anti-aging drugs.

    Science.gov (United States)

    Blagosklonny, Mikhail V

    2013-12-01

    Recent groundbreaking discoveries have revealed that IGF-1, Ras, MEK, AMPK, TSC1/2, FOXO, PI3K, mTOR, S6K, and NFκB are involved in the aging process. This is remarkable because the same signaling molecules, oncoproteins and tumor suppressors, are well-known targets for cancer therapy. Furthermore, anti-cancer drugs aimed at some of these targets have been already developed. This arsenal could be potentially employed for anti-aging interventions (given that similar signaling molecules are involved in both cancer and aging). In cancer, intrinsic and acquired resistance, tumor heterogeneity, adaptation, and genetic instability of cancer cells all hinder cancer-directed therapy. But for anti-aging applications, these hurdles are irrelevant. For example, since anti-aging interventions should be aimed at normal postmitotic cells, no selection for resistance is expected. At low doses, certain agents may decelerate aging and age-related diseases. Importantly, deceleration of aging can in turn postpone cancer, which is an age-related disease.

  7. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    HR Division

    2001-01-01

    Members of the personnel and their families, holders of SWISS LEGITIMATION CARDS due to expire during the year 2001, need to change them. Those concerned should bring : a recent passport photo (with NAME and first name on the back) the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to Bureau des cartes, building 33/1-009/1-015. Members of the personnel will be notified by the Social and Statutary Conditions Group, HR Division as soon as the new cards are available. Be careful: If you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsibility in case of difficulties with the customs authorities or the police.

  8. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    HR DIVISION

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDSdue to expire during the year 2000, need to change them.Those concerned should bring:a recent passport photo (with NAME and first name on the back)the expired (or due to expire) card and a photocopy (for certified authentication)to: Bureau des cartes, building 33/1-025Members of personnel will be notified by HR Division as soon as the new cards are available.Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsibility in case of difficulties with the customs authorities or the police.Human Resources DivisionTel. 79494-74683

  9. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    HR Division

    2000-01-01

    Members of the personnel, holders ofSWISS LEGITIMATION CARDSdue to expire during the year 2000, need to change them.Those concerned should bring:a recent passport photo (with NAME and first name on the back)the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to:Bureau des cartes, Bât 33.1-009/1-011.HR Division will notify members of personnel as soon as the new cards are available.Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organisation will not take any responsibility in case of difficulties with the customs authorities or the police.Human Resources DivisionTel. 79494-74683

  10. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Division des Ressources Humaines

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDSdue to expire during the year 2000, need to change them.Those concerned should bring:-\ta recent passport photo (with NAME and first name on the back)-\tthe expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to:Bureau des cartes, bât 33.1-009/1-011.HR Division will notify members of personnel as soon as the new cards are available.Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organisation will not take any responsibility in case of difficulties with the customs authorities or the police.Human Resources DivisionTel. 79494-74683

  11. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Human Resources Division; Human Resources Division; Tel. 79494-74683

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDS due to expire during the year 2000, need to change them. Those concerned should bring: ­ a recent passport photo (with NAME and first name on the back) ­ the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to: Bureau des cartes, Bât 33.1-009/1-011 Members of the personnel will be notified by HR Division as soon as the new cards are available. Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsability in case of difficulties with the customs authorities or the police.

  12. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Division des Ressources Humaines; Human Resources Division; Tel. 79494-74683

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDS due to expire during the year 2000, need to change them. Those concerned should bring : a recent passport photo (with NAME and first name on the back) the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication)to: Bureau des cartes, Bât 33.1-009/1-011. Members of personnel will be notified by HR Division as soon as the new cards are available. Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsibility in case of difficulties with the customs authorities or the police.

  13. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Division des Ressources Humaines; Human Resources Division; Tel. 79494-74683

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDS due to expire during the year 2000, need to change them. Those concerned should bring : - a recent passport photo (with NAME and first name on the back) - the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to: Bureau des cartes, bât 33.1-009/1-011. HR Division will notify members of personnel as soon as the new cards are available. Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsibility in case of difficulties with the customs authorities or the police.

  14. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Division des Ressources Humaines; Human Resources Division; Tel. 79494-74683

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDS due to expire during the year 2000, need to change them. Those concerned should bring: - a recent passport photo (with NAME and first name on the back) - the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to: Bureau des cartes, bldg 33.1-009/1-011. HR Division will notify members of personnel as soon as the new cards are available.Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organisation will not take any responsibility in case of difficulties with the customs authorities or the police.

  15. [Comment on the misappropriation of bibliographical references in science. The example of anti-aging medicine].

    Science.gov (United States)

    Cogan, E

    2015-01-01

    This work constitutes a argued analysis of the publication of the article of Hertoghe et al. "Anti aging medicine, a science based, essential medicine " whose full and unreviewed publication was forced in the framework of the Belgian law on the right of reply to an earlier publication entitled " Anti-Aging Medicine: Science or Marketing? ". We confirm the absence of scientific evidence on the effectiveness of hormonal treatments used in this approach by highlighting the different techniques allowing doctors who promote this approach to make believe in their effectiveness. This is clearly to mix in one sentence established truths and unproven facts, use references inappropriately especially by misappropriation of studies on groups of patients with hormone deficiency in order to justify treatment in healthy subjects, to ignore recent references undermining ancient literature, to betray the authors' conclusions. Our critical analysis is also considering compliance with the guidelines for integrity in scientific publications.

  16. Patient interest in and familiarity with anti-aging therapies: A survey of the general dermatology clinic population.

    Science.gov (United States)

    Darland, Allison M; Chubb, Heather A; Sachs, Dana L; Helfrich, Yolanda R

    2017-08-03

    The appearance of aging skin is a common complaint among dermatology patients. There is an expanding market for anti-aging therapies, but little information is available regarding which patients utilize these treatments and patient preferences regarding treatment. To describe the patient population utilizing anti-aging therapies, assess patient familiarity with treatment options, and learn where treatment information is most often obtained. Three hundred patients were surveyed in the University of Michigan General Dermatology Clinic. Fifty-three percent of the general dermatology patient population has used an anti-aging treatment in the past; 66% reported interest in the future use. Interest is high among all genders, ages, and incomes. Most subjects obtained treatment information from magazines, but subjects were more likely to pursue treatment if information was obtained from a dermatologist. Demographics of anti-aging therapy are changing, and a wide variety of patients pursue treatment. Patients are largely unfamiliar with most treatment options and are more likely to pursue treatment after receiving treatment information from a dermatologist. The information presented in this study is helpful to both dermatologists and marketers of anti-aging products. © 2017 Wiley Periodicals, Inc.

  17. Entrepreneurship as a legitimate field of knowledge.

    Science.gov (United States)

    Sánchez, José C

    2011-08-01

    Entrepreneurship as a research topic has been approached from disciplines such as economics, sociology or psychology. After justifying its study, we define the domain of the field, highlighting what has currently become its dominant paradigm, the process of the discovery, assessment and exploitation of opportunities. We then describe the main perspectives and offer an integrated conceptual framework that will allow us to legitimize the study of entrepreneurship as a field of knowledge in its own right. We believe that this framework will help researchers to better recognize the relations among the many factors forming part of the study of entrepreneurship. Lastly, we conclude with some brief reflections on the potential value of the framework presented.

  18. LEGITIMIZATION OF OWNERSHIP IN THE CONDITIONS OF TRANSITION ECONOMY

    Directory of Open Access Journals (Sweden)

    V. Branovitskiy

    2015-03-01

    Full Text Available This article studies the problem of structural deformations of property in post-privatization period, via the lack of public awareness ofthe property legitimacy that constantly produces utopian political slogans and public dissatisfaction with the current redistribution of property. Two completely opposite instruments of legitimization of property by means of nationalization and constitutional reform are examined. Conclusions are focused on the implementation of economic constitutionalism policy as a way of legitimizing the owner in Ukraine and building democratic and legal state. Emphasis is put on the confidence improvement of authority agents and counteract of the crisis of neoliberal capitalism, when rich people grow rich thanks to the poor segment of population as an essential mechanisms for public perception of property legalization and providing them with status quo. Legitimization of owner is objectively necessary condition for society reconstruction on the way of entrenchment of fundamental dominants of markets and civil society.

  19. On new industry creation and legitimation

    DEFF Research Database (Denmark)

    Turcan, Romeo V.; Fraser, Norman

    an initial condition in which an industry does not exist to a final condition in which it is institutionalized. We ground our discussion in a typology of legitimation. Both authors bring to the discussion their ethnographic experience in creating and legitimating new industries and new ventures......The purpose of this paper is to discuss the process of creation and legitimation of new industries. Specifically, the question we address is how to cross the gulf between no industry and embryonic industry in order for a new industry to emerge. In this, our focus is on the process of change from...

  20. Benefits of Anti-Aging Actives in Sunscreens

    Directory of Open Access Journals (Sweden)

    Karl Lintner

    2017-01-01

    Full Text Available Sunscreens are functional, utilitarian, cosmetic products. The criteria of purchase are different from those for skin care and make-up. Companies are trying to add glamour and value to basic sunscreens by incorporating “active” ingredients (other than UV filters into these formulas and by communicating about the additional benefits, be they anti-aging, moisturizing, firming, anti-wrinkle, etc. While some of these ideas of additional ingredients make sense as supplementary skin protection, some others do not afford much benefit in view of the infrequent application and short period of usage. The present article reviews some of these ideas and presents a few active ingredients that might be of value in such a context, even if substantiation of such additional claims in sunscreens is often lacking.

  1. Two Chinese Medical Master’s Students Aspiring to Publish Internationally: A Longitudinal Study of Legitimate Peripheral Participation in Their Communities of Practice

    Directory of Open Access Journals (Sweden)

    Na Luo

    2015-04-01

    Full Text Available This paper explores how two Chinese medical Master’s students’ international publication success/failure and their academic English learning outcomes were related to their agency and the social context in which they were embedded by using the notions of legitimate peripheral participation (LPP and community of practice (CoP. While both students were highly motivated and similarly limited in English proficiency, their publication and academic English literacy learning outcomes vastly differed. Analysis via the lenses of LPP and CoP reveals that their differences in scholarly achievement in terms of international publication success and academic English learning outcomes can be convincingly explained by variation in the structure of the CoPs to which they belonged. Their respective CoPs determine their amount and quality of co-participation or mutual engagement with old-timers, particularly the master, which ultimately led to markedly different publication and academic English learning outcomes. Accordingly, I argue that institutions must consider the amount of mutual engagement senior researchers can afford to their research students when allocating advising responsibilities to professors.

  2. Repurposing FDA-approved drugs for anti-aging therapies.

    Science.gov (United States)

    Snell, Terry W; Johnston, Rachel K; Srinivasan, Bharath; Zhou, Hongyi; Gao, Mu; Skolnick, Jeffrey

    2016-11-01

    There is great interest in drugs that are capable of modulating multiple aging pathways, thereby delaying the onset and progression of aging. Effective strategies for drug development include the repurposing of existing drugs already approved by the FDA for human therapy. FDA approved drugs have known mechanisms of action and have been thoroughly screened for safety. Although there has been extensive scientific activity in repurposing drugs for disease therapy, there has been little testing of these drugs for their effects on aging. The pool of FDA approved drugs therefore represents a large reservoir of drug candidates with substantial potential for anti-aging therapy. In this paper we employ FINDSITE comb , a powerful ligand homology modeling program, to identify binding partners for proteins produced by temperature sensing genes that have been implicated in aging. This list of drugs with potential to modulate aging rates was then tested experimentally for lifespan and healthspan extension using a small invertebrate model. Three protein targets of the rotifer Brachionus manjavacas corresponding to products of the transient receptor potential gene 7, ribosomal protein S6 polypeptide 2 gene, or forkhead box C gene, were screened against a compound library consisting of DrugBank drugs including 1347 FDA approved, non-nutraceutical molecules. Twenty nine drugs ranked in the top 1 % for binding to each target were subsequently included in our experimental analysis. Continuous exposure of rotifers to 1 µM naproxen significantly extended rotifer mean lifespan by 14 %. We used three endpoints to estimate rotifer health: swimming speed (mobility proxy), reproduction (overall vitality), and mitochondria activity (cellular senescence proxy). The natural decline in swimming speed with aging was more gradual when rotifers were exposed to three drugs, so that on day 6, mean swimming speed of females was 1.19 mm/s for naproxen (P = 0.038), 1.20 for fludarabine (P = 0

  3. Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin.

    Science.gov (United States)

    Jung, Minyoung; Lee, Sanghoon; Park, Hwa-young; Youm, Jong-Kyung; Jeong, Sekyoo; Bae, Jonghwan; Kwon, Mi Jung; Park, Byeong Deog; Lee, Seung Hun; Choi, Eung Ho

    2011-04-01

    Recently, we reported on the anti-ageing effects of K6PC-5. This compound induced keratinocyte differentiation and fibroblast proliferation by increasing sphingosine-1 phosphate synthesis. We performed this study to confirm the anti-ageing effects of new synthetic products (the K6EAA series) derived from K6PC-5 through an amino group induction. Cellular responses such as differentiation, proliferation and calcium mobilization were investigated using cultured human keratinocytes and fibroblasts. Also, we measured the expressions of collagen mRNA and protein using real time RT-PCR and ELISA, respectively. The K6EAA-L12 product, selected by in vitro screening, was evaluated for anti-ageing effects on intrinsically and extrinsically (photo) aged models of hairless mice. In the intrinsically aged murine skin, K6EAA-L12 showed anti-ageing effects by activating collagen synthesis, eventually causing dermal thickening. Also, in the photo-aged skin, the dermal collagen density and dermal thickness were increased. In photo-aged murine skin, K6EAA-L12 increased stratum corneum integrity by increasing corneodesmosome density and improved the barrier recovery rate. However, there were no changes in the expressions of epidermal differentiation maker proteins. In conclusion, topical K6EAA-L12, a new synthetic K6PC-5 derivative, improves intrinsically and extrinsically (photo) aged skin by increasing the collagen density and improving the skin barrier function. © 2011 John Wiley & Sons A/S.

  4. Top 10 botanical ingredients in 2010 anti-aging creams.

    Science.gov (United States)

    Cronin, Hyland; Draelos, Zoe Diana

    2010-09-01

    New developments in the realm of skin rejuvenation such as phytotherapy are at an astounding increasing pace in the cosmeceutical market. Yet, many of these products that are classified as cosmeceuticals are tested less vigorously and do not have to be approved by the Food and Drug Administration to establish efficacy and safety. Thus, as clinicians, we must ask the question, "Is there science-based evidence to validate the mechanism of these new treatments?" We assessed the top anti-aging creams currently on the market specifically evaluating their botanical ingredients. Some of the most common botanicals that are hot off the market are: Rosmarinus officinalis, Vitis vinifera (grape seed extract), Citronellol, Limonene, Oenothera biennis (evening primrose), Glycyrrhiza glabra (licorice extract), Aframomum angustifolium seed extract, Diosgenin (wild yam), N6 furfuryladenine (kinetin), and Ergothioneine. Through researching each of these botanical ingredients, we have concluded that randomized controlled trials are still needed in this area, but there is promise in some of these ingredients and science to validate them. © 2010 Wiley Periodicals, Inc.

  5. Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

    Directory of Open Access Journals (Sweden)

    Saima Jadoon

    2015-01-01

    Full Text Available The exposure to ultraviolet radiations (UVR is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS, leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

  6. Professionalism as an Agent of Legitimation.

    Science.gov (United States)

    Tuchman, Gaye

    1978-01-01

    Criticizes Elihu Katz's understanding of professionalism in media journalism as used in his report to the British Broadcasting Corporation (on social research on broadcasting), on the grounds that reporting the news should not be the agent for legitimizing the event. (JMF)

  7. Legitimation as a particular mode of strategic communication in the public sector

    DEFF Research Database (Denmark)

    Aggerholm, Helle Kryger; Thomsen, Christa

    2016-01-01

    Within the theoretical frameworks of strategic communication and legitimation and through the use of a case study analysis, this article investigates the creation of managerial legitimation towards internal stakeholders in text and talk as a particular mode of strategic communication in a public...... sector organization. Following a theoretical discussion of the interconnectedness of strategic communication and managerial legitimation, we present a case study analysis of management talk at three interrelated management meetings dealing with the implementation of New Public Management-based (NPM...... talk happens at a microlevel and is used as a particular mode of strategic communication....

  8. Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells

    DEFF Research Database (Denmark)

    Rattan, Suresh I S; Eskildsen-Helmond, Yvonne E G; Beedholm, Rasmus

    2004-01-01

    at the levels of maintenance of stress protein profile; reduction in the accumulation of oxidatively and glycoxidatively damaged proteins; stimulation of the proteasomal activities for the degradation of abnormal proteins; improved cellular resistance to ethanol, hydrogenperoxide, and ultraviolet-B rays......In a series of experimental studies we have shown that repetitive mild heat stress has anti-aging hormetic effects on growth and various other cellular and biochemical characteristics of human skin fibroblasts undergoing aging in vitro. We have reported the hormetic effects of repeated challenge...... of cellular responsiveness to mild and severe heat stress. Furthermore, we are also undertaking comparative studies using non-aging immortal cell lines, such as SV40-transformed human fibroblasts, spontaneous osteosarcoma cells, and telomerase-immortalized human bone marrow cells for establishing differences...

  9. When is normative recruitment legitimate?

    Directory of Open Access Journals (Sweden)

    Lars Øystein Ursin

    2008-11-01

    Full Text Available Rosamond Rhodes and John Harris have both recently argued that we all have a general moral duty to participate in medical research. However, neither Rhodes' nor Harris' arguments in support of this obligation stand up to scrutiny, and severe and convincing criticism has been levelled against their case. Still, to refute their arguments is not to refute the conclusion. There seems to be some truth in the view that when people are asked to take part in medical research, their choice is not completely morally neutral. In this article, we argue that the proper question to ask is when, rather than if, a certain moral duty to volunteer for medical research can be appealed to. To answer this question, we need a denser description of relevant research projects and their context rather than just describing medical research in general. Drawing on our study of participants in the Norwegian HUNT biobank, we use the normative implications of the Norwegian concept «dugnad» as an analogy to discuss the requirement of providing neutral information to potential biobank participants in order to promote their free and informed decision as to whether or not to take part. We suggest that normative recruitment is not just a question of principles and ethics. It is also a question of research design and the creation of the common good in the community where the research takes place.http://dx.doi.org/10.5324/eip.v2i2.1697

  10. Botanical extracts as anti-aging preparations for the skin: a systematic review.

    Science.gov (United States)

    Hunt, Katherine J; Hung, Shao Kang; Ernst, Edzard

    2010-12-01

    Although topical creams and other anti-aging products purport to reduce the appearance of aging and skin wrinkling, there has been no critical analysis in the scientific literature of their effectiveness. This systematic review critically evaluates the evidence for the effectiveness or efficacy of botanical treatments in reducing skin aging and wrinkling. MEDLINE, Embase, CINAHL®, CENTRAL and AMED databases were searched from their inception until October 2009. Reference lists of retrieved articles were hand-searched. Manufacturers and professional associations were contacted in order to identify further non-published studies. No language restrictions were applied. Only randomized clinical trials or controlled clinical trials assessing the effectiveness of botanical extracts in reducing wrinkling and aging of the skin were included. Data were extracted by two independent reviewers and methodological quality was assessed using the Jadad score and key aspects of the Cochrane risk of bias tool. Of 36 potentially relevant studies, 11 trials of botanical extracts for reducing skin wrinkling and the appearance of aging met all the inclusion criteria. No trials were identified following contact with anti-aging and cosmetic organizations, companies and professional bodies. A significant reduction in skin wrinkling was noted for date kernel extract, cork extract, soy extract, Rosaceae and peony extract. No significant reduction was noted for green tea, Vitaphenol® (a combination of green and white teas, mangosteen and pomegranate extract) or maca root. All trials were of poor methodological quality. Adverse effects were frequently not reported. In summary, there is some weak evidence to suggest that several botanical extracts may be effective in reducing the appearance of skin aging but no evidence that this effect is enduring. Independent replications with larger, more diverse samples, longer treatment durations and more rigorous study designs are required to validate

  11. Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid

    Directory of Open Access Journals (Sweden)

    Anthony Arlia-Ciommo

    2014-09-01

    Full Text Available Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research.

  12. Anti-Aging Activity and Non-Toxic Dose of Phytooxyresveratrol from ...

    African Journals Online (AJOL)

    Erah

    , 4Division of Medical Molecular. Biology, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University,. Bangkok 10700, Thailand. Abstract. Purpose: To determine the anti-aging activity and toxicity doses ...

  13. Formulasi dan Evaluasi Sediaan Masker Sheet yang Mengandung Provitamin B5 Sebagai Anti-Aging

    OpenAIRE

    Calson

    2016-01-01

    Background: As people age, intrinsic and extrinsic factors can make our skin show signs of aging and lose its adolescence. For example, wrinkles, fine lines and etc. This condition can be also experienced by young people which is called premature aging. The common products on the market usually use vitamin B complex as anti-aging. Provitamin B5 is one of vitamin B complex constituents which is a natural humectants that can moisturize, restores skin elasticity and provides anti-aging effects. ...

  14. An "enigmatic" L-carnosine (β-alanyl-L-histidine)? Cell proliferative activity as a fundamental property of a natural dipeptide inherent to traditional antioxidant, anti-aging biological activities: balancing and a hormonally correct agent, novel patented oral therapy dosage formulation for mobility, skeletal muscle power and functional performance, hypothalamic-pituitary- brain relationship in health, aging and stress studies.

    Science.gov (United States)

    Babizhayev, Mark A; Yegorov, Yegor E

    2015-01-01

    Hypothalamic releasing and inhibiting hormones are major neuroendocrine regulators of human body metabolism being driven directly to the anterior pituitary gland via hypothalamic-hypophyseal portal veins. The alternative physiological or therapeutic interventions utilizing the pharmaco-nutritional boost of imidazole-containing dipeptides (non-hydrolized oral form of carnosine, carcinine, N-acetylcarnosine lubricant eye drops) can maintain health, enhance physical exercise performance and prevent ageing. Carnosine (β-alanyl-L-histidine) is synthesized in mammalian skeletal muscle. There is an evidence that the release of carnosine from the skeletal muscle sarcomeres moieties during physical exercise affects autonomic neurotransmission and physiological functions. Carnosine released from skeletal muscle during exercise acts as a powerful afferent physiological signaling stimulus for hypothalamus, may be transported into the hypothalamic tuberomammillary nucleus (TMN), specifically to TMN-histamine neurons and hydrolyzed herewith via activities of carnosine-degrading enzyme (carnosinase 2) localized in situ. Through the colocalized enzymatic activity of Histidine decarboxylase in the histaminergic neurons, the resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of carnosine on neurotransmission and physiological function. Carnosine and its imidazole-containing dipeptide derivatives are renowned for their anti-aging, antioxidant, membrane protective, metal ion chelating, buffering, anti-glycation/ transglycating activities used to prevent and treat a spectrum of age-related and metabolic diseases, such as neurodegenerative disease, sight threatening eye diseases, Diabetes mellitus and its complications, cancers and other disorders due to their wide spectrum biological activities. The precursor of carnosine (and related imidazole containing compounds) synthesis in skeletal muscles beta-alanine is used as the

  15. A Legitimate Freedom Approach to Sustainability

    DEFF Research Database (Denmark)

    Crabtree, Andrew

    2012-01-01

    an integrate sustainability into the Human Development Index would thus give the wrong policy message. Drawing on the works of Amartya Sen and Thomas Scanlon, this article argues that sustainable development can be seen as a process of increasing legitimate freedoms, the freedoms that others cannot reasonably...... reject. Thus, Sen's vision of development as freedom is amended to suggest limits to freedoms. Forms of development which are not sustainable can be reasonably rejected due, at least, to the harm and blighting entailed. Based on this, it is argued that at country level of comparison the Human Development...

  16. Public Relations and CSR as a Part of Corporate Legitimation

    Directory of Open Access Journals (Sweden)

    Irene Buhăniță

    2015-10-01

    Full Text Available This article provides a review of public relations literature in relation with CSR, through an analysis of academic research done in 1999-2014 period and published in three main scientific journals. The content of this literature shows that researchers looked for new perspectives along the years, broadening Clark’s approach (2000 of communication management to encompass management function and relationship management as well. The findings of the study suggest that the accent on processes may address ethics or legitimation topics in public relation as well as in CSR, because of the improved relationships they can establish between organizations, stakeholders and society.

  17. Legitimate workplace roles and activities for early learners.

    Science.gov (United States)

    Chen, H Carrie; Sheu, Leslie; O'Sullivan, Patricia; Ten Cate, Olle; Teherani, Arianne

    2014-02-01

    Given the calls for earlier student engagement in clinical experiences, educators are challenged to define roles for pre-clerkship students that enable legitimate participation in clinical practice. This study aimed to determine the student roles and activities, as well as the clinic characteristics, that allow early student engagement within a specific clinical experience. The authors conducted semi-structured interviews in December 2011 and January 2012 with a purposive sample of medical student and faculty volunteers at student-run clinics (SRCs). They were asked to discuss and compare student roles in SRCs with those in the core curriculum. An inductive approach and iterative process were used to analyse the interview transcripts. Themes identified from initial open coding were organised using the sensitising concepts of workplace learning and communities of practice and subsequently applied to code all transcripts. A total of 22 medical students and four faculty advisors were interviewed. Thematic analysis revealed pre-clerkship student roles in direct patient care (patient triage, history and physical examinations, patient education, laboratory and immunisation procedures) and in clinic management (patient follow-up, staff management, quality improvement). Students took ownership of patients and occupied central roles in the function of the clinic, with faculty staff serving as peripheral resources. Clinic-related features supporting this degree of legitimate participation included defined scopes of practice, limited presenting illnesses, focused student training, and clear protocols and operations manuals. Pre-clerkship students are capable of legitimately participating in patient care experiences to an extent not usually available to them. The SRC represents one example of how early clinical experiences in the core curriculum might be transformed through the provision of patient care activities of narrow scope. © 2014 John Wiley & Sons Ltd.

  18. Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum.

    Science.gov (United States)

    Lai, Cora Sau-Wan; Yu, Man-Shan; Yuen, Wai-Hung; So, Kwok-Fai; Zee, Sze-Yong; Chang, Raymond Chuen-Chung

    2008-01-23

    Ganoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi) is a medicinal fungus used clinically in many Asian countries to promote health and longevity. Synaptic degeneration is another key mode of neurodegeneration in Alzheimer's disease (AD). Recent studies have shown the loss of synaptic density proteins in each individual neuron during the progression of AD. It was recently reported that beta-amyloid (Abeta) could cause synaptic dysfunction and contribute to AD pathology. In this study, we reported that aqueous extract of G. lucidum significantly attenuated Abeta-induced synaptotoxicity by preserving the synaptic density protein, synaptophysin. In addition, G. lucidum aqueous extract antagonized Abeta-triggered DEVD cleavage activities in a dose-dependent manner. Further studies elucidated that phosphorylation of c-Jun N-terminal kinase, c-Jun, and p38 MAP kinase was attenuated by G. lucidum in Abeta-stressed neurons. Taken together, the results prove a hypothesis that anti-aging G. lucidum can prevent harmful effects of the exterminating toxin Abeta in AD.

  19. Validation of anti-aging drugs by treating age-related diseases.

    Science.gov (United States)

    Blagosklonny, Mikhail V

    2009-03-28

    Humans die from age-related diseases, which are deadly manifestations of the aging process. In order to extend life span, an anti-aging drug must delay age-related diseases. All together age-related diseases are the best biomarker of aging. Once a drug is used for treatment of any one chronic disease, its effect against other diseases (atherosclerosis, cancer, prostate enlargement, osteoporosis, insulin resistance, Alzheimer's and Parkinson's diseases, age-related macular degeneration) may be evaluated in the same group of patients. If the group is large, then the anti-aging effect could be validated in a couple of years. Startlingly, retrospective analysis of clinical and preclinical data reveals four potential anti-aging modalities.

  20. Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway.

    Science.gov (United States)

    Hsu, Shih-Che; Huang, Shih-Ming; Lin, Shih-Hua; Ka, Shuk-Man; Chen, Ann; Shih, Meng-Fu; Hsu, Yu-Juei

    2014-12-01

    Gender is known to be associated with longevity and oestrogen administration induced longevity-associated gene expression is one of the potential mechanisms underlying the benefits of oestrogen on lifespan, whereas the role of testosterone in the regulation of longevity-associated gene expressions remains largely unclear. The klotho gene, predominantly expressed in the kidney, has recently been discovered to be an aging suppressor gene. In the present study, we investigated the regulatory effects of testosterone on renal klotho gene expression in vivo and in vitro. In testosterone-administered mouse kidney and NRK-52E cells, increased klotho expression was accompanied by the up-regulation of the nuclear androgen receptor (AR). Overexpression of AR enhanced the expression of klotho mRNA and protein. Conversely, testosterone-induced klotho expression was attenuated in the presence of flutamide, an AR antagonist. A reporter assay and a chromatin immunoprecipitation (ChIP) assay demonstrated that AR directly binds to the klotho promoter via androgen response elements (AREs) which reconfirmed its importance for AR binding via the element mutation. In summary, our study demonstrates that testosterone up-regulates anti-aging klotho together with AR expression in the kidney in vivo and in vitro by recruiting AR on to the AREs of the klotho promoter.

  1. Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans.

    Science.gov (United States)

    Jeon, Hoon; Cha, Dong Seok

    2016-05-01

    The present study investigated the effects and underlying mechanism of ethylacetate fraction of Ribes fasciculatum (ERF) on the lifespan and stress tolerance using a Caenorhabditis elegans model. The longevity activity of ERF was determined by lifespan assay under normal culture condition. The survival rate of nematodes under various stress conditions was assessed to validate the effects of ERF on the stress tolerance. To determine the antioxidant potential of ERF, the superoxide dismutase (SOD) activities and intracellular reactive oxygen species (ROS) levels were investigated. The ERF-mediated change in SOD-3 expression was examined using GFP-expressing transgenic strain. The effects of ERF on the aging-related factors were investigated by reproduction assay and pharyngeal pumping assay. The intestinal lipofuscin levels of aged nematodes were also measured. The mechanistic studies were performed using selected mutant strains. Our results indicated that ERF showed potent lifespan extension effects on the wild-type nematode under both normal and various stress conditions. The ERF treatment also enhanced the activity and expression of superoxide dismutase (SOD) and attenuated the intracellular ROS levels. Moreover, ERF-fed nematodes showed decreased lipofuscin accumulation, indicating ERF might affect age-associated changes in C. elegans. The results of mechanistic studies indicated that there was no significant lifespan extension in ERF-treated daf-2, age-1, sir-2.1, and daf-16 null mutants, suggesting that they were involved in ERF-mediated lifespan regulation. In conclusion, R. fasciculatum confers increased longevity and stress resistance in C. elegans via SIR-2.1-mediated DAF-16 activation, dependent on the insulin/IGF signaling pathway. Copyright © 2016 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  2. Antioxidant and Anti-aging Activities of Silybum Marianum Protein Hydrolysate in Mice Treated with D-galactose.

    Science.gov (United States)

    Zhu, Shu Yun; Jiang, Ning; Tu, Jie; Yang, Jing; Zhou, Yue

    2017-09-01

    In the present study, we investigated the antioxidant and anti-aging effects of Silybum marianum protein hydrolysate (SMPH) in D-galactose-treated mice. D-galactose (500 mg/kg body weight) was intraperitoneally injected daily for 7 weeks to accelerate aging, and SMPH (400, 800, 1,200 mg/kg body weight, respectively) was simultaneously administered orally. The antioxidant and anti-aging effects of SMPH in the liver and brain were measured by biochemical assays. Transmission electron microscopy (TEM) was performed to study the ultrastructure of liver mitochondri. SMPH decreased triglyceride and cholesterol levels in the D-galactose-treated mice. It significantly elevated the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC), which were suppressed by D-galactose. Monoamine oxidase (MAO) and malondialdehyde (MDA) levels as well as the concentrations of caspase-3 and 8-OHdG in the liver and brain were significantly reduced by SMPH. Moreover, it increased Bcl-2 levels in the liver and brain. Furthermore, SMPH significantly attenuated D-galactose-induced liver mitochondrial dysfunction by improving the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase as well as mitochondrial membrane potential (ΔΨm) and fluidity. TEM showed that the degree of liver mitochondrial damage was significantly decreased by SMPH. The results indicated that SMPH protects against D-galactose-induced accelerated aging in mice through its antioxidant and anti-aging activities. Copyright © 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

  3. Apple Can Act as Anti-Aging on Yeast Cells

    Directory of Open Access Journals (Sweden)

    Vanessa Palermo

    2012-01-01

    Full Text Available In recent years, epidemiological and biochemical studies have shown that eating apples is associated with reduction of occurrence of cancer, degenerative, and cardiovascular diseases. This association is often attributed to the presence of antioxidants such as ascorbic acid (vitamin C and polyphenols. The substances that hinder the presence of free radicals are also able to protect cells from aging. In our laboratory we used yeast, a unicellular eukaryotic organism, to determine in vivo efficacy of entire apples and their components, such as flesh, skin and polyphenolic fraction, to influence aging and oxidative stress. Our results indicate that all the apple components increase lifespan, with the best result given by the whole fruit, indicating a cooperative role of all apple components.

  4. Preparation, Characterization, and Biological Activities of Topical Anti-Aging Ingredients in a Citrus junos Callus Extract

    Directory of Open Access Journals (Sweden)

    Deepak Adhikari

    2017-12-01

    Full Text Available In this study, we prepared and characterized a callus extract from Citrus junos and assessed its utility as a source of topical anti-aging ingredients. Callus extract was produced by aqueous extraction from Citrus junos grown on Murashige and Skoog medium with picloram as a growth regulator. After measuring the total phenolic and flavonoid contents, the major phenolic compound in calli was identified as p-hydroxycinnamoylmalic acid (1 by spectroscopic analysis. The total phenol content in the extract was determined to be 24.50 ± 0.43 mg/g of gallic acid equivalents; however, the total flavonoid content of the extract was not determined. The biological activities of the callus extract, in terms of skin anti-aging, were assessed by measuring the anti-tyrosinase activity in, and melanogenesis by, melanoma cells; and proliferation of, and procollagen synthesis by, human fibroblasts. The callus extract was incorporated into nanoliposomes (NLs to improve its percutaneous absorption. Addition of the callus extract resulted in a 1.85-fold decrease in the melanin content of melanocytes compared with that with arbutin. The extract (500 μg/mL significantly promoted the proliferation of, and procollagen synthesis by, fibroblasts (by 154% and 176%, respectively. In addition, the flux through the human epidermis of Citrus junos callus extract incorporated into NLs was 17.67-fold higher than that of the callus extract alone. These findings suggest that Citrus junos callus extract-loaded NLs have promise as an anti-aging cosmetic, as well as having a skin-lightening effect.

  5. The Effect in Topical Use of Lycogen(TM) via Sonophoresis for Anti-aging on Facial Skin.

    Science.gov (United States)

    Hsin-Ti, Lai; Wen-Sheng, Liu; Yi-Chia, Wu; Ya-Wei, Lai; Wen, Zhi-Hong; David, Wang Hui-Min; Su-Shin, Lee

    2015-01-01

    Anti-aging skin care is a growing popular topic in cosmetic and aesthetic fields, and skin care rather then makeup tips draw more attention nowadays. The phenomenon of skin aging includes thinning of skin losses of elasticity and moisture, pigmented spot formation, and wrinkle development. Along with growth in age, the decreased rates of epithelium renewal and cellular recovery as well as the reduced contents of elastin, collagen, and glycosaminoglycans all contribute to creases or folds of skin. Available strategies for wrinkle treatments include topical use of skin care products with anti-aging contents, dermabrasion, laser, Botox injection, fillers injection, and facelift. Though all of these above options can provide different degrees of improvement in facial wrinkles, the cost-effect, pain of intervention therapy, and necessity of repetitive treatment may impact on choices made. Topical use of anti-aging skin products is the most convenient and cheap way to achieve skin anti-aging effect. Lycogen(TM) is an antioxidant, which can prevent the downregulation of pro-collagen I, intracellular accumulation of malondialdehyde (MDA) and achieve the aim of skin rejuvenation. Twenty-six female patients were included in our study with ages between 30 and 45. They were randomly assigned to two groups: the vehicle control group and the experimental group. Patients in the control group applied a skin care product without Lycogen(TM)to the face via sonophoresis after facial cleanser use in the morning and at night. The experimental group applied a Lycogen(TM) -containing skin care product via sonophoresis in the same time schedule. We evaluated results, including pigmented spots, wrinkles, texture, pores, and red area by VISIA on weeks 0, 1, 2, 4, 6, 8, and 10 respectively. In the aspect of pigmented spots, the experimental group showed significant difference in comparison with the vehicle control group on weeks 2, 6, 8, and 10. For wrinkles, the experimental group had

  6. Anti-Aging Activity and Non-Toxic Dose of Phytooxyresveratrol from ...

    African Journals Online (AJOL)

    Purpose: To determine the anti-aging activity and toxicity doses of phytooxyresveratrol extracted from Artocarpus lakoocha Roxb. Methods: Artocarpus lakoocha 100 g was extracted with 2 ml of 95 % ethanol to obtain phytooxyresveratrol (POV). Total phenolic content, as well as free radical scavenging and anti-glycation ...

  7. Legitimation and the Party of Power in Kazakhstan

    NARCIS (Netherlands)

    Del Sordi, A.; Brusis, M.; Ahrens, J.; Schulze Wessel, M.

    2016-01-01

    This chapter surveys the legitimation strategies enacted by the political leadership of the contemporary post-Soviet republic. While showing that Kazakhstan bases its legitimation primarily on international recognition and the country’s economic performance, it also focuses on an institutional

  8. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.

    Science.gov (United States)

    Chiu, Pin-Chi; Chan, Chih-Chieh; Lin, Hui-Min; Chiu, Hsien-Ching

    2007-12-01

    Kinetin and niacinamide are used in the cosmetic industry as anti-aging agents. Neither the interactive/additive effects of these compounds nor the anti-aging efficacy on Asian skin has been studied. Objective To assess the clinical anti-aging effects and efficacy differences between kinetin plus niacinamide and niacinamide alone vs. vehicle placebo in an Asian cohort. Fifty-two Taiwanese subjects were enrolled in a randomized, double-blind, placebo-controlled, split-face comparative study. Group 1 subjects were treated with kinetin 0.03% plus niacinamide 4%, whereas group 2 subjects received niacinamide 4%. The treatment formulation was applied on one side of the face, whereas a placebo was applied on the other for a period of 12 weeks. We used noninvasive biometrological instruments to evaluate a variety of skin parameters at baseline and at weeks 4, 8, and 12. Persistent and significant reductions in spot, pore, wrinkle, and evenness counts were found at weeks 8 and 12 in group 1. A significant increase in corneal hydration status was also evident at week 12, whereas persistent decreases in erythema index were apparent at 8 and 12 weeks. In group 2, significant reductions in pore and evenness counts at week 8 and wrinkle counts at week 12 were noted. We found kinetin and niacinamide exert a synergistic anti-aging effect. Our data suggest that these compounds have multiactive, multifunctional, and pluripotent effects on skin. They are also both promising to be included in the cutaneous anti-aging cosmeceuticals in the future.

  9. Chitin-Hyaluronan Nanoparticles: A Multifunctional Carrier to Deliver Anti-Aging Active Ingredients through the Skin

    Directory of Open Access Journals (Sweden)

    Pierfrancesco Morganti

    2014-07-01

    Full Text Available The paper describes the process to produce Chitin Nanofibril-Hyaluronan nanoparticles (CN-HA, showing their ability to easily load active ingredients, facilitate penetration through the skin layers, and increase their effectiveness and safety as an anti-aging agent. Size and characterization of CN-HA nanoparticles were determined by Scanning Electron Microscopy (SEM and Zetasizer, while encapsulation efficiency and loading capacity of the entrapped ingredients were controlled by chromatographic and spectrophotometric methods. Safeness was evidenced on fibroblasts and keratinocytes culture viability by the MTT (Methylthiazol assay; anti-aging activity was evaluated in vitro measuring antioxidant capacity, anti-collagenase activity, and metalloproteinase and pro-inflammatory release; efficacy was shown in vivo by a double-blind vehicle-controlled study for 60 days on 60 women affected by photo-aging. In addition, the CN-HA nanoparticles have shown interesting possibility to be used as active ingredients, for designing and making advanced medication by the electrospinning technology, as well as to produce transparent films for food packaging, by the casting method, and can be used also in their dry form as tissues or films without adding preservatives. These unusual CN-HA nanoparticles obtained from the use of raw materials of waste origin may offer an unprecedented occasion for making innovative products, ameliorating the quality of life, reducing pollution and safeguarding the environment’s integrity.

  10. [Research of anti-aging mechanism of ginsenoside Rg1 on brain].

    Science.gov (United States)

    Li, Cheng-peng; Zhang, Meng-si; Liu, Jun; Geng, Shan; Li, Jing; Zhu, Jia-hong; Zhang, Yan-yan; Jia, Yan-yan; Wang, Lu; Wang, Shun-he; Wang, Ya-ping

    2014-11-01

    Neurodegenerative disease is common and frequently occurs in elderly patients. Previous studies have shown that ginsenoside Rg1 was able to inhibit senescent of brain, but the mechanism on the brain during the treatment remains elucidated. To study the mechanism of ginsenoside Rg1 in the process of anti-aging of brain, forty male SD rats were randomly divided into normal group, Rg1 normal group, brain aging model group and Rg1 brain aging model group, each group with 10 rats (brain aging model group: subcutaneous injection of D-galactose (120 mg kg(-1)), qd for 42 consecutive days; Rg1 brain aging model group: while copying the same test as that of brain aging model group, begin intraperitoneal injection of ginsenosides Rg1 (20 mg x kg(-1)) qd for 27 d from 16 d. Rg1 normal group: subcutaneous injection of the same amount of saline; begin intraperitoneal injection of ginsenosides Rg1 (20 mg x kg(-1)) qd for 27 d from 16 d. Normal: injected with an equal volume of saline within the same time. Perform the related experiment on the second day after finishing copying the model or the completion of the first two days of drug injections). Learning and memory abilities were measured by Morris water maze. The number of senescent cells was detected by SA-beta-Gal staining while the level of IL-1 and IL-6 proinflammatory cytokines in hippocampus were detected by ELISA. The activities of SOD, contents of GSH in hippo- campus were quantified by chromatometry. The change of telomerase activities and telomerase length were performed by TRAP-PCR and southern blotting assay, respectively. It is pointed that, in brain aging model group, the spatial learning and memory capacities were weaken, SA-beta-Gal positive granules increased in section of brain tissue, the activity of antioxidant enzyme SOD and the contents of GSH decreased in hippocampus, the level of IL-1 and IL-6 increased in hippocampus, while the length of telomere and the activity of telomerase decreased in hippocampus

  11. Anti-aging drugs reduce hypothalamic inflammation in a sex-specific manner.

    Science.gov (United States)

    Sadagurski, Marianna; Cady, Gillian; Miller, Richard A

    2017-08-01

    Aging leads to hypothalamic inflammation, but does so more slowly in mice whose lifespan has been extended by mutations that affect GH/IGF-1 signals. Early-life exposure to GH by injection, or to nutrient restriction in the first 3 weeks of life, also modulate both lifespan and the pace of hypothalamic inflammation. Three drugs extend lifespan of UM-HET3 mice in a sex-specific way: acarbose (ACA), 17-α-estradiol (17αE2), and nordihydroguaiaretic acid (NDGA), with more dramatic longevity increases in males in each case. In this study, we examined the effect of these anti-aging drugs on neuro-inflammation in hypothalamus and hippocampus. We found that age-associated hypothalamic inflammation is reduced in males but not in females at 12 months of age by ACA and 17αE2 and at 22 months of age in NDGA-treated mice. The three drugs blocked indices of hypothalamic reactive gliosis associated with aging, such as Iba-1-positive microglia and GFAP-positive astrocytes, as well as age-associated overproduction of TNF-α. This effect was not observed in drug-treated female mice or in the hippocampus of the drug-treated animals. On the other hand, caloric restriction (CR; an intervention that extends the lifespan in both sexes) significantly reduced hypothalamic microglia and TNF-α in both sexes at 12 months of age. Together, these results suggest that the extent of drug-induced changes in hypothalamic inflammatory processes is sexually dimorphic in a pattern that parallels the effects of these agents on mouse longevity and that mimics the changes seen, in both sexes, of long-lived nutrient restricted or mutant mice. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  12. Mitochondrial Protection and Anti-aging Activity of Astragalus Polysaccharides and Their Potential Mechanism

    Directory of Open Access Journals (Sweden)

    Xiao-Juan Xin

    2012-02-01

    Full Text Available The current study was performed to investigate mitochondrial protection and anti-aging activity of Astragalus polysaccharides (APS and the potential underlying mechanism. Lipid peroxidation of liver and brain mitochondria was induced by Fe2+–Vit C in vitro. Thiobarbituric acid (TBA colorimetry was used to measure the content of thiobarbituric acid reactive substances (TBARS. Mouse liver mitochondrial permeability transition (PT was induced by calcium overload in vitro and spectrophotometry was used to measure it. The scavenging activities of APS on superoxide anion (O2•- and hydroxyl radical (•OH, which were produced by reduced nicotinamide adenine dinucleotide (NADH—N-Methylphenazonium methyl sulfate (PMS and hydrogen peroxide (H2O2–Fe2+ system respectively, were measured by 4-nitrobluetetrazolium chloride (NBT reduction and Fenton reaction colorimetry respectively. The Na2S2O3 titration method was used to measure the scavenging activities of APS on H2O2. APS could inhibit TBARS production, protect mitochondria from PT, and scavenge O2•-, •OH and H2O2 significantly in a concentration-dependent manner respectively. The back of the neck of mice was injected subcutaneously with D-galactose to induce aging at a dose of 100 mg/kg/d for seven weeks. Moreover, the activities of catalase (CAT, surperoxide dismutase (SOD and glutathione peroxidase (GPx and anti-hydroxyl radical which were assayed by using commercial monitoring kits were increased significantly in vivo by APS. According to this research, APS protects mitochondria by scavenging reactive oxygen species (ROS, inhibiting mitochondrial PT and increasing the activities of antioxidases. Therefore, APS has the effect of promoting health.

  13. Representation, Legitimation, and Autoethnography: An Autoethnographic Writing Story

    Directory of Open Access Journals (Sweden)

    Nicholas L. Holt

    2003-03-01

    Full Text Available The purpose of this article is to critique representation and legitimation as they relate to the peer review process for an autoethnographic manuscript. Using a conversation derived from seven reviewers' comments pertaining to one autoethnographic manuscript, issues relating to (a the use of verification strategies in autoethnographic studies; and, (b the use of self as the only data source are discussed. As such, this paper can be considered as an autoethnographic writing story. The problematic nature of autoethnography, which is located at the boundaries of scientific research, is examined by linking the author's experiences of the review process with dominant research perspectives. Suggestions for investigators wishing to produce autoethnographic accounts are outlined along with a call for the development of appropriate evaluative criteria for such work.

  14. Formulasi Masker Wajah dari Minyak Biji Buah Anggur (Grape Seed Oil) sebagai Anti-Aging

    OpenAIRE

    Putra, Handy Pramana

    2016-01-01

    Background: Tropical climate may cause increased risk of skin damage or premature aging. This couldtriggering the formation of free radicals in the skin that cause wrinkles. Grape seed oil contains linoleic acid (Omega 6), oleic acid, stearic acid, palmitic acid and antioxidants such as vitamin E and OPC was beneficial to inhibit the free radicals. Objective: Formulation of grape seed oil in the preparation of face mask anti-aging and to determine the effect of different concentrations of ...

  15. Crisis of Youth or Youth in Crisis? Education, Employment and Legitimation Crisis

    Science.gov (United States)

    Simmons, Robin; Smyth, John

    2016-01-01

    This paper uses the Habermasian concept of legitimation crisis to critique the relationship between post-compulsory education and training and the chronic levels of youth unemployment and under-employment which now characterise post-industrial Western economies, such as the UK. It draws on data from an ethnographic study of the lives of young…

  16. Legitimate Permissions And Specifity Of Their Enforceability In Modern Russia

    Directory of Open Access Journals (Sweden)

    Vitaly Subochev

    2014-01-01

    Full Text Available Northern Caucasus Institute of Advanced Training (branch of Krasnodar University of Ministry of Internal Affairs of Russia, 123, Malbahova Street, Nalshik, 360016, Russia. Abstract: The article investigates the basic legal permissions in Russian law - legal rights, freedoms and legitimate interests. Potential of these means of legal regulation is examined as well as their common features and essential differences. Authors argue that the effectiveness of the mechanism of legal regulation largely depends on the proper use of legal permissions. Particular attention is paid to such kind of legal mean as a legitimate interest. The article draws attention to the fact that if a legal right or freedom are such kind of permissions which are guaranteed by the law in order to sustain certain demands of subjects of law, the legitimate interest is qualitatively different mean of regulation. The authors suggest considering a legitimate interest as reflected in the objective law legal possibility of subjects of law to enjoy certain social benefits and to seek protection from the state authorities in order to meet their interests which are not contradictory to provisions of law. Qualitative difference between legitimate interest and legal right and freedom is that the legitimate interest is an opportunity, guaranteed to a lesser extent than the permitted behavior within a legal right or freedom. Legitimate interest is a mere permission, admitted by the state and to some extent supported by it. But legal right and freedom - are those means of regulation, which are directly approved and sanctioned by the state which presuppose duty of a person to a particular behavior. The author's vision of the specifity of legal enforcement of legitimate admissions is presented.

  17. LEGITIMATE PERMISSIONS AND SPECIFITY OF THEIR ENFORCEABILITY IN MODERN RUSSIA

    Directory of Open Access Journals (Sweden)

    Vitaly Subochev

    2014-01-01

    Full Text Available Northern Caucasus Institute of Advanced Training (branch of Krasnodar University of Ministry of Internal Affairs of Russia, 123, Malbahova Street, Nalshik, 360016, Russia. Abstract: The article investigates the basic legal permissions in Russian law - legal rights, freedoms and legitimate interests. Potential of these means of legal regulation is examined as well as their common features and essential differences. Authors argue that the effectiveness of the mechanism of legal regulation largely depends on the proper use of legal permissions. Particular attention is paid to such kind of legal mean as a legitimate interest. The article draws attention to the fact that if a legal right or freedom are such kind of permissions which are guaranteed by the law in order to sustain certain demands of subjects of law, the legitimate interest is qualitatively different mean of regulation. The authors suggest considering a legitimate interest as reflected in the objective law legal possibility of subjects of law to enjoy certain social benefits and to seek protection from the state authorities in order to meet their interests which are not contradictory to provisions of law. Qualitative difference between legitimate interest and legal right and freedom is that the legitimate interest is an opportunity, guaranteed to a lesser extent than the permitted behavior within a legal right or freedom. Legitimate interest is a mere permission, admitted by the state and to some extent supported by it. But legal right and freedom - are those means of regulation, which are directly approved and sanctioned by the state which presuppose duty of a person to a particular behavior. The author's vision of the specifity of legal enforcement of legitimate admissions is presented.

  18. Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol.

    Science.gov (United States)

    Farris, Patricia; Zeichner, Joshua; Berson, Diane

    2016-07-01

    Consumers are increasingly interested in over-the-counter skin care products that can improve the appearance of photodamaged and aging skin. This 10-week, open-label, single- center study enrolled 25 subjects with mild to moderate hyperpigmentation and other clinical stigmata of cutaneous aging including fine lines, sallowness, lack of clarity, and wrinkling. Their mean age was 53.4±7.7 years. The test product contained retinol 0.5% in combination with niacinamide 4.4%, resveratrol 1%, and hexylresorcinol 1.1% in a moisturizing base. Subjects were provided a skin care regimen including a cleanser, hydrating serum, moisturizer, and an SPF 30 sunscreen for daily use. The test product was applied only at night. The use of this skin brightening/anti-aging cosmeceutical was found to provide statistically significant improvements in all efficacy endpoints by study end. Fine lines, radiance, and smoothness were significantly improved as early as week 2 (P<.001). By week 4, hyperpigmentation, overall skin clarity, evenness of skin tone, and wrinkles showed statistically significant improvement compared to baseline. Mild retinoid dermatitis including flaking and redness occurred early in the study as reflected by tolerability scores. By week 10, subjects reported no stinging, itching, dryness, or tingling. The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection. J Drugs Dermatol. 2016;15(7):863-868.

  19. Coercive and legitimate authority impact tax honesty: evidence from behavioral and ERP experiments.

    Science.gov (United States)

    Gangl, Katharina; Pfabigan, Daniela M; Lamm, Claus; Kirchler, Erich; Hofmann, Eva

    2017-07-01

    Cooperation in social systems such as tax honesty is of central importance in our modern societies. However, we know little about cognitive and neural processes driving decisions to evade or pay taxes. This study focuses on the impact of perceived tax authority and examines the mental chronometry mirrored in ERP data allowing a deeper understanding about why humans cooperate in tax systems. We experimentally manipulated coercive and legitimate authority and studied its impact on cooperation and underlying cognitive (experiment 1, 2) and neuronal (experiment 2) processes. Experiment 1 showed that in a condition of coercive authority, tax payments are lower, decisions are faster and participants report more rational reasoning and enforced compliance, however, less voluntary cooperation than in a condition of legitimate authority. Experiment 2 confirmed most results, but did not find a difference in payments or self-reported rational reasoning. Moreover, legitimate authority led to heightened cognitive control (expressed by increased MFN amplitudes) and disrupted attention processing (expressed by decreased P300 amplitudes) compared to coercive authority. To conclude, the neuronal data surprisingly revealed that legitimate authority may led to higher decision conflict and thus to higher cognitive demands in tax decisions than coercive authority. © The Author (2017). Published by Oxford University Press.

  20. Anti-aging effects of Piper cambodianum P. Fourn. extract on normal human dermal fibroblast cells and a wound-healing model in mice.

    Science.gov (United States)

    Lee, Hyunji; Hong, Youngeun; Kwon, So Hee; Park, Jongsun; Park, Jisoo

    2016-01-01

    Aging of skin is associated with environmental factors such as ultraviolet rays, air pollution, gravity, and genetic factors, all of which can lead to wrinkling of skin. Previous reports suggest that the wound repair is impaired by the aging process and strategies to manipulate the age-related wound healing are necessary in order to stimulate repair. Several traditional plant extracts are well-known for their properties of skin protection and care. Piper cambodianum P. Fourn. (PPF), a member of Piperacecae, is a plant found in Vietnam that might have therapeutic properties. Therefore, the effects of PPF stem and leaf extract on aging process were investigated in vitro and in vivo. PPF extract dissolved in methanol was investigated using Western blotting, real-time quantitative reverse transcription-polymerase chain reaction, flow cytometry, and cell wound-healing assays. We assessed the anti-aging effect of PPF in mouse using the wound-healing assay. The results were analyzed by Student's unpaired t-test; *Pwound-healing effects in mice. This study demonstrated the anti-aging and wound-healing effects of PPF extract. Therefore, PPF extract represents a promising new therapeutic agent for anti-aging and wound-healing treatments.

  1. [Psychological Distress and Acceptance of Violence Legitimizing Masculinity Norms among Adolescents].

    Science.gov (United States)

    Klein, Eva M; Wölfling, Klaus; Beutel, Manfred E; Dreier, Michael; Müller, Kai W

    2017-04-01

    The proportion of adolescent migrants in Germany aged 15-20 years has risen to about 29.5% in 2014 according to Federal census statistics. The purpose of the current study was to describe and to compare the psychological strains of adolescent 1 st and 2 nd generation migrants with non-migrants in a representative school survey. Acceptance of violence legitimizing masculinity norms was explored and its correlation with psychological strain was analyzed. Self-reported data of psychological strain (internalizing and externalizing problems) and acceptance of violence legitimizing masculinity were gathered among 8 518 pupils aged 12-19 years across different school types. Among the surveyed adolescents, 27.6% reported a migration background (5.8% 1 st generation migrants; 21.8% 2 nd generation migrants). Particularly 1 st generation migrants scored higher in internalizing and externalizing problems than 2 nd generation migrants or non-migrants. The differences, however, were small. Adolescents with migration background suffered from educational disadvantage, especially 1 st generation migrants. Male adolescents reported significantly higher acceptance of violence legitimizing masculinity norms than their female counterparts. Strong agreement with the measured concept of masculinity was found among pupils of lower secondary school and adolescents reported regularly tobacco and cannabis consumption. The acceptance of violence legitimizing masculinity norms was greater among migrants, particularly 1 st generation migrants, than non-migrants. Overall, high acceptance of violence legitimizing masculinity norms was related to externalizing problems, which can be understood as dysfunctional coping mechanisms of social disadvantage and a lack of prospects. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Anti-aging effects of Piper cambodianum P. Fourn. extract on normal human dermal fibroblast cells and a wound-healing model in mice

    Directory of Open Access Journals (Sweden)

    Lee H

    2016-07-01

    that PPF-treated cells displayed dose-dependent increase in messenger RNA expression levels of collagen, elastin, and hyaluronan synthase-2 and decreased expression levels of matrix metalloproteinase-1 aging gene. PPF treatment led to decreased production of reactive oxygen species in cells subjected to ultraviolet irradiation. Furthermore, PPF extract showed positive wound-healing effects in mice.Conclusion: This study demonstrated the anti-aging and wound-healing effects of PPF extract. Therefore, PPF extract represents a promising new therapeutic agent for anti-aging and wound-healing treatments. Keywords: PPF extract, anti-aging, wound healing, antioxidant, ROS, normal human dermal fibroblasts

  3. The Monopoly of Legitimate Force : Denationalization, or Business as Usual?

    OpenAIRE

    Jachtenfuchs, Markus

    2014-01-01

    As Max Weber and many others in his tradition have argued, the monopoly of the legitimate use of physical force is the core of the modern state. What counts here is not the frequency of the actual use of force but the fact that only the state has the legitimate right to use such force. The military and the police are the most concrete expressions of this monopoly. In recent decades, the use of the military and the police has been subject to external challenges – ‘globalization’ – and new idea...

  4. Strategic Spatial Planning's Role in Legitimizing Investments in Transport Infrastructure

    DEFF Research Database (Denmark)

    Olesen, Kristian

    how the recently proposed vision of a Loop City for the Danish/Swedish Øresund Region has played an important role in legitimizing and building political support for a light railway connecting the outer suburbs of Copenhagen. It is not unusual for large investments in new transport infrastructures...... railway and Loop City planning processes together with document analysis of background reports and analyses from the last 10-15 years, the paper investigates to what extent the vision of a Loop City has played an important role in legitimizing the need for a light railway in the outer suburbs...

  5. Anti-aging Friction of Carbonate Fault Mirror and its Microstructural Interpretation

    Science.gov (United States)

    Park, Y.; Ree, J. H.; Hirose, T.

    2017-12-01

    In our slide-hold-slide (SHS) friction tests on carbonate fault rocks, fault mirror (FM), light reflective mirror-like fault surface, shows almost zero or slightly negative aging rate of friction (`anti-aging' friction), whereas carbonate faults without FM exhibit a positive aging rate. We analyzed microstructures from three types of carbonate faults to explore the cause of the anti-aging friction of FM. The three types of fault rocks before SHS tests were made from Carrara marble; (i) FM, (ii) crushed gouge of former FM (CF), and (iii) gouge produced by pre-shearing of Carrara marble (PR). The fault zone of FM before SHS tests consists of sintered nanograin patches smeared into negative asperities of wall rocks (thickness up to 150 μm) and a sintered gouge layer between wall rocks (thickness up to 200 μm) that is composed of tightly-packed nanograins (50-500 nm in size) with triple junctions and angular-subangular fragments (a few-100 μm) of sintered nanograin aggregates. A straight and discrete Y-shear surface defines a boundary between the gouge layer and the nanograin patches or between the layer and wall rock. CF specimens before SHS tests are composed of patches of sintered nanograins as in FM specimens and a porous gouge layer with finer nanograins (a few-20 nm in size) and angular fragments of former FM. PR specimens before SHS tests are composed of damaged wall rocks and porous gouge with finer nanograins (a few-tens of μm). After SHS tests, sintered appearance of grains within the fault zones of CF and PR indicates the increase in interparticle bonding and also in contact area by grain aggregation. In contrast, the gouge layer of FM specimens after SHS tests consists mostly of angular fragments of sintered nanograin aggregates. The angular shape of the fragments indicates little increase in bonding and contact area between the fragments. Tightly sintered nanograins in FM specimens would have a lower chemical reactivity with their size coarser and

  6. A future for the doctrine of substantive legitimate expectation? The ...

    African Journals Online (AJOL)

    I consider the implications of the creative approach in KZN JLC for the development of the doctrine of substantive legitimate expectation under administrative law in future. Finally I discuss how the creation of a new legal mechanism to enforce publicly promulgated promises to pay was "subversive of PAJA and the scheme in ...

  7. Academic leadership in nursing: legitimating the discipline in contested spaces.

    Science.gov (United States)

    McNamara, Martin S

    2009-05-01

    To investigate the potential of recent conceptual developments in the sociology of education for conceptualising academic leadership in nursing. During an investigation into the current status and future trajectory of academic nursing in Ireland, academic leadership emerged as a major concern for respondents. The languages of legitimation of academic leaders were elicited in in-depth interviews and analysed as expressions of underlying legitimation principles. The concept of legitimation principles provides a way of thinking about how academic nursing is positioned in the health and higher education sectors, how its leaders construct its identity, practices and purposes, and clarifies the proper focus and goals of academic leadership in nursing. Academic leadership is concerned with legitimating the discipline of nursing as an autonomous, coherent and distinctive professional and academic endeavour. This legitimacy must be secured in academic, clinical and wider contexts in which academic nursing is viewed with ambivalence; leaders must take account of the impact of nursing history on the current status and future trajectory of the discipline. The analytic tools facilitate a better understanding of the internal and external conditions under which academic nursing will flourish, or wither, in contemporary higher education.

  8. British nuclear power: protest and legitimation 1945 - 1980

    International Nuclear Information System (INIS)

    Welsh, I.

    1988-02-01

    This thesis traces the development of British civil nuclear power policy between 1945 and 1982. Throughout particular attention is paid to the methods of legitimation which have been used to justify this policy in the public arena. By tracing this legitimation process, and public responses to it, the modern anti nuclear movement and crisis of public acceptability are placed within an historical context. It is argued that public concern and disquiet have always required the active legitimation of nuclear policy from the inception of the technology. The initial base of this legitimation was largely symbolic and associated nuclear power with the future of civilisation and a second of Elizabethan splendour for Britain. Symbolic legitimacy was underpinned by the twin pillars of expert hegemony and political authority. As these became increasingly prominent due to internal disputes within the industry secrecy was applied as a means of preserving legitimacy. Having tried conventional avenues of opposition the anti nuclear movement then embarked upon a campaign of direct action. The links between this campaign and the pervasive sense of public unease which had always existed are explored. It is argued here that the anti nuclear movement produces and sustains a cogent critique of nuclear power. Campaigning around this critique wins the movement increasing legitimacy as its arguments are increasingly accepted. (author)

  9. "Roda Boa", "Roda Boa": Legitimate Peripheral Participation in Diasporic "Capoeira"

    Science.gov (United States)

    Stephens, Neil; Delamont, Sara

    2010-01-01

    "Capoeira", the Brazilian dance and martial art, is taught across the world. Learners acquire vital knowledge and are socialised as "capoeiristas" through legitimate peripheral participation, in particular when watching games in the "roda". The "roda", the circle within which the "capoeira" game is played, is a classic place for learning by…

  10. The Legitimization of Dialectic: Socratic Strategy in the "Gorgias."

    Science.gov (United States)

    Palmerton, Patricia

    In the "Gorgias," Plato focuses attention upon the value of dialectic as opposed to rhetoric, as well as the status of orators as opposed to philosophers. Through his agent, Socrates, Plato confirms dialectic as a legitimate endeavor while calling into question the place of rhetoric. Socrates is portrayed as a director who enacts a…

  11. Building a Legitimate and Accountable State in South Sudan ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Building a Legitimate and Accountable State in South Sudan: Political Dimensions Beyond the Comprehensive Peace Accord. Policymakers and researchers believe that inclusive political settlements are vital to avoiding a relapse into violence in conflict-affected and fragile contexts. Despite numerous comparative ...

  12. Hegemony and Humanitarian Norms: The U.S. Legitimation of Toxic Violence

    Directory of Open Access Journals (Sweden)

    Eric Bonds

    2015-08-01

    Full Text Available Despite widespread beliefs that the United States has not used chemical weapons since the distant past of World War I, this study suggests a more complicated history by examining U.S. use of herbicides and incapacitating gases in the Vietnam War and its use of herbicides in the "War on Drugs." This article places such use of toxic violence within a context of U.S. hegemony, by which U.S. officials have used contested forms of violence to secure geopolitical goals, but have also been pressured to comply with humanitarian norms or-when there is a gap between norms and state policy-to do legitimating work in order to maintain domestic and international consent. Based on case study analysis of archival and secondary sources, this article identifies three main techniques U.S. officials use to legitimate contested forms of violence. These techniques are defensive categorization, humanitizing discourse, and surrogacy.

  13. Crisis of youth or youth in crisis? Education, employment and legitimation crisis

    OpenAIRE

    Simmons, Robin; Smyth, John

    2016-01-01

    This paper uses the Habermasian concept of legitimation crisis to critique the relationship between post-compulsory education and training and the chronic levels of youth unemployment and under-employment which now characterise post-industrial Western economies, such as the UK. It draws on data from an ethnographic study of the lives of young people classified as NEET (not in education, employment or training), or at risk of becoming so to challenge dominant discourses about youth unemploymen...

  14. Market Legitimacy: An Investigation into the Legitimation of Hispanic Cultural Markets

    OpenAIRE

    Ruvalcaba, Cecilia

    2015-01-01

    This study explores the processes involved in the evolution of cultural markets as legitimate institutional arrangements in the context of the U.S. Hispanic market. This research consists of a historical analysis of newspaper articles from 1984 to 2010 in the Wall Street Journal and USA Today in order to obtain a view of the processes involved in the evolution of the Hispanic market as a viable entity. The research uncovers the industry, marketing and societal processes which contribute to t...

  15. Effects of Aging and Anti-Aging Hormones on The Kidney, The Thyroid Functions and The Histology of The Testis of Male Albino Rats

    OpenAIRE

    Shadia Ali Radwan; Samia Mohamed Sakr; Mohamed Salah Al-Shinnawy and Enas Saleh Abdel-Bakey

    2011-01-01

    The present study was carried out to evaluate the effect of aging and anti-aging hormones on the kidney, the thyroid and the testis of aged male albino rats from the physiological and histological points of view. Material & Methods Thirty five male rats were used in the present study. They were allocated into five groups. The first group (5months old) served as control group and the other remaining groups are (18 months old). The second group 1 ml/kg b.w. corn oil intramuscular injection thro...

  16. Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction

    Energy Technology Data Exchange (ETDEWEB)

    Chiba, Takuya, E-mail: takuya@nagasaki-u.ac.jp [Department of Investigative Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan); Tsuchiya, Tomoshi [Division of Surgical Oncology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501 (Japan); Komatsu, Toshimitsu; Mori, Ryoichi; Hayashi, Hiroko [Department of Investigative Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan); Shimano, Hitoshi [Department of Internal Medicine (Endocrinology and Metabolism), Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba Ibaraki 305-8575 (Japan); Spindler, Stephen R. [Department of Biochemistry, Room 5478, Boyce Hall, University of California - Riverside, Riverside, CA 92521 (United States); Shimokawa, Isao [Department of Investigative Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan)

    2010-10-15

    Research highlights: {yields} We identified four sequence motifs lying upstream of putative pro-longevity genes. {yields} One of these motifs binds to HNF-4{alpha}. {yields} HNF-4{alpha}/PGC-1{alpha} could up-regulate the transcription of a reporter gene linked to this motif. {yields} The reporter system described here could be used to screen candidate anti-aging molecules. -- Abstract: Suppression of the growth hormone/insulin-like growth factor-I pathway in Ames dwarf (DF) mice, and caloric restriction (CR) in normal mice extends lifespan and delays the onset of age-related disorders. In combination, these interventions have an additive effect on lifespan in Ames DF mice. Therefore, common signaling pathways regulated by DF and CR could have additive effects on longevity. In this study, we tried to identity the signaling mechanism and develop a system to assess pro-longevity status in cells and mice. We previously identified genes up-regulated in the liver of DF and CR mice by DNA microarray analysis. Motif analysis of the upstream sequences of those genes revealed four major consensus sequence motifs, which have been named dwarfism and calorie restriction-responsive elements (DFCR-REs). One of the synthesized sequences bound to hepatocyte nuclear factor-4{alpha} (HNF-4{alpha}), an important transcription factor involved in liver metabolism. Furthermore, using this sequence information, we developed a highly sensitive bioassay to identify chemicals mimicking the anti-aging effects of CR. When the reporter construct, containing an element upstream of a secreted alkaline phosphatase (SEAP) gene, was co-transfected with HNF-4{alpha} and its regulator peroxisome proliferator-activated receptor (PPAR) {gamma} coactivator-1{alpha} (PGC-1{alpha}), SEAP activity was increased compared with untransfected controls. Moreover, transient transgenic mice established using this construct showed increased SEAP activity in CR mice compared with ad libitum-fed mice. These data

  17. The challenge of legitimizing spatially differentiated regulation

    DEFF Research Database (Denmark)

    Thorsøe, Martin Hvarregaard; Graversgaard, Morten; Noe, Egon

    2017-01-01

    to the legitimacy of agri-environmental regulation that occurs when the regulatory regime changes from general regulation to differentiated regulation. The analysis is based on a case study of the implementation of the Buffer zone act in Denmark – a regulation that prevents agricultural production in a 10 (later 9...

  18. Consumers as tutors – legitimate teachers?

    Directory of Open Access Journals (Sweden)

    Owen Cathy

    2004-09-01

    Full Text Available Abstract Background The aim of this study was to research the feasibility of training mental health consumers as tutors for 4th year medical students in psychiatry. Methods A partnership between a consumer network and an academic unit in Psychological Medicine was formed to jointly develop a training package for consumer tutors and a curriculum in interviewing skills for medical students. Student attitudes to mental health consumers were measured pre and post the program. All tutorial evaluation data was analysed using univariate statistics. Both tutors and students evaluated the teaching program using a 4 point rating scale. The mean scores for teaching and content for both students and tutors were compared using an independent samples t-test. Results Consumer tutors were successfully trained and accredited as tutors and able to sustain delivery of tutorials over a 4 year period. The study found that whilst the medical students started with positive attitudes towards consumers prior to the program, there was a general trend towards improved attitude across all measures. Other outcomes for tutors and students (both positive and negative are described. Conclusions Consumer tutors along with professional tutors have a place in the education of medical students, are an untapped resource and deliver largely positive outcomes for students and themselves. Further possible developments are described.

  19. Becoming Socialized into a New Professional Role: LPN to BN Student Nurses' Experiences with Legitimation

    Directory of Open Access Journals (Sweden)

    Sherri Melrose

    2012-01-01

    Full Text Available This paper presents findings from a qualitative descriptive study that explored the professional socialization experiences of Licensed Practical Nurses (LPNs who attended an online university to earn a Baccalaureate degree in nursing (BN, a prerequisite to writing the Canadian Registered Nurse (RN qualifying exam. The project was framed from a constructivist worldview and Haas and Shaffir’s theory of legitimation. Participants were 27 nurses in a Post-LPN to BN program who came from across Canada to complete required practicums. Data was collected from digital recordings of four focus groups held in different cities. Transcripts were analyzed for themes and confirmed with participants through member checking. Two overarching themes were identified and are presented to explain how these unique adult learners sought to legitimize their emerging identity as Registered Nurses (RNs. First, Post-LPN to BN students need little, if any, further legitimation to affirm their identities as “nurse.” Second, practicum interactions with instructors and new clinical experiences are key socializing agents.

  20. Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

    Science.gov (United States)

    Menendez, Javier A.; Joven, Jorge; Aragonès, Gerard; Barrajón-Catalán, Enrique; Beltrán-Debón, Raúl; Borrás-Linares, Isabel; Camps, Jordi; Corominas-Faja, Bruna; Cufí, Sílvia; Fernández-Arroyo, Salvador; Garcia-Heredia, Anabel; Hernández-Aguilera, Anna; Herranz-López, María; Jiménez-Sánchez, Cecilia; López-Bonet, Eugeni; Lozano-Sánchez, Jesús; Luciano-Mateo, Fedra; Martin-Castillo, Begoña; Martin-Paredero, Vicente; Pérez-Sánchez, Almudena; Oliveras-Ferraros, Cristina; Riera-Borrull, Marta; Rodríguez-Gallego, Esther; Quirantes-Piné, Rosa; Rull, Anna; Tomás-Menor, Laura; Vazquez-Martin, Alejandro; Alonso-Villaverde, Carlos; Micol, Vicente; Segura-Carretero, Antonio

    2013-01-01

    Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of the nutrient-sensing mTOR gerogene. mTOR-driven aging can be triggered or accelerated by a decline or loss of responsiveness to activation of the energy-sensing protein AMPK, a critical gerosuppressor of mTOR. The occurrence of age-related diseases, therefore, reflects the synergistic interaction between our evolutionary path to sedentarism, which chronically increases a number of mTOR activating gero-promoters (e.g., food, growth factors, cytokines and insulin) and the “defective design” of central metabolic integrators such as mTOR and AMPK. Our laboratories at the Bioactive Food Component Platform in Spain have initiated a systematic approach to molecularly elucidate and clinically explore whether the “xenohormesis hypothesis,” which states that stress-induced synthesis of plant polyphenols and many other phytochemicals provides an environmental chemical signature that upregulates stress-resistance pathways in plant consumers, can be explained in terms of the reactivity of the AMPK/mTOR-axis to so-called xenohormetins. Here, we explore the AMPK/mTOR-xenohormetic nature of complex polyphenols naturally present in extra virgin olive oil (EVOO), a pivotal component of the Mediterranean style diet that has been repeatedly associated with a reduction in age-related morbid conditions and longer life expectancy. Using crude EVOO phenolic extracts highly enriched in the secoiridoids oleuropein aglycon and decarboxymethyl oleuropein aglycon, we show for the first time that (1) the anticancer activity of EVOO secoiridoids is related to the activation of anti-aging/cellular stress-like gene signatures, including endoplasmic reticulum (ER) stress and the unfolded protein response, spermidine and polyamine metabolism, sirtuin-1 (SIRT1) and NRF2 signaling; (2) EVOO secoiridoids activate AMPK and suppress crucial genes involved in the Warburg effect and the self-renewal capacity of

  1. Science, consumerism and bureaucracy: the new legitimations of medical professionalism

    OpenAIRE

    Harrison, Stephen; Mcdonald, Ruth

    2003-01-01

    This paper argues that the means by which the profession of medicine has to legitimise itself in the context of state‐provided health services is changing in a way that may be summarised in Weberian terms as a shift from substantive to formal rationality. The traditional model for such legitimations, evident in the UK over the last 50 years, relied heavily on professional interpretation of emergent patient needs, on professional pragmatism as a means of coping with resource limitations, on un...

  2. Ways of explaining sexual harassment: motivating, enabling and legitimizing processes

    OpenAIRE

    Diehl, Charlotte

    2014-01-01

    This dissertation aims to contribute to a comprehensive explanation of sexual harassment by the investigation of three social-psychological processes, which seem to crucially contribute to the etiology of sexual harassment: motivation to sexually harass (e.g., power or sexuality), enabling processes (e.g., through diverse situational cues), and legitimization of sexually harassing behavior (e.g., by applying myths about sexual harassment). By consolidating these three processes into one multi...

  3. Legitimation, Kooptation und Repression in der Volksrepublik China

    OpenAIRE

    Goebel, Christian

    2012-01-01

    "This article examines the interaction of legitimation, cooptation, and repression in China's authoritarian consolidation. It shows that the totalitarian regime under Mao Zedong was characterized by a low degree of performance and cooptation and that it had to rely on extreme repression and ideological indoctrination to stay in power. After the death of Mao Zedong, the character of the regime changed markedly. The new elites made sparing use of repression and indoctrination but did not compen...

  4. Legitimizing ESS Big Science as a collaboration across boundaries

    CERN Document Server

    O'Dell, Tom

    2013-01-01

    Legitimizing ESS 'Big Science' is a broad epithet that can be associated with research projects as different as the Manhattan Project, the Hubble Telescope-construction, and the CERN-establishment in Geneva. While the science produced by these projects is vastly different, they have in common the fact that they all involve huge budgets, big facilities, complex instrumentation, years of planning, and large multidis...

  5. Legitimating New Forms of Organizing and New International Activities in the Eyes of Multiple Stakeholders

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    by its multiple stakeholders; and (2) what legitimation strategies it developed and adopted to legitimate itself in the eyes of its multiple stakeholders. Theoretically, the paper is grounded within legitimation theory. The empirical context is defined by a new, international NGO entering an established...

  6. Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants.

    Science.gov (United States)

    Ayaz, Muhammad; Sadiq, Abdul; Junaid, Muhammad; Ullah, Farhat; Subhan, Fazal; Ahmed, Jawad

    2017-01-01

    The use of essential oils (EOs) and their components is known since long in traditional medicine and aromatherapy for the management of various diseases, and is further increased in the recent times. The neuroprotective and anti-aging potentials of EOs and their possible mechanism of actions were evaluated by numerous researchers around the globe. Several clinically important EOs and their components from Nigella sativa , Acorus gramineus, Lavandula angustifolia, Eucalyptus globulus, Mentha piperita, Rosmarinus officinalis, Jasminum sambac, Piper nigrum and so many other plants are reported for neuroprotective effects. This review article was aimed to summarize the current finding on EOs tested against neurodegenerative disorders like Alzheimer disease (AD) and dementia. The effects of EOs on pathological targets of AD and dementia including amyloid deposition (Aβ), neurofibrillary tangles (NFTs), cholinergic hypofunction, oxidative stress and glutamatergic abnormalities were focused. Furthermore, effects of EOs on other neurological disorders including anxiety, depression, cognitive hypofunction epilepsy and convulsions were also evaluated in detail. In conclusion, EOs were effective on several pathological targets and have improved cognitive performance in animal models and human subjects. Thus, EOs can be developed as multi-potent agents against neurological disorders with better efficacy, safety and cost effectiveness.

  7. Anti-aging by means of physical education (on example of swimming

    Directory of Open Access Journals (Sweden)

    N.V. Fedyniak

    2016-12-01

    Full Text Available Purpose: to work out complex anti-aging program to find its influence on biological age and tem of elderly persons’ ageing. Material: in experiment 78 persons (44 men and 34 women with accelerated organism’s ageing participated. Two groups were formed. In both groups trainings were conducted three times a week. Each training took 55-80 minutes. Realization of the program was in three stages: preparatory-adaptive, training and supporting. Testing of the author’s program took ten months. For determination of biological (functional age and temp of organism’s ageing we used methodic by V.P. Voytenko. Results: we expanded ideas about slowing of involution changes in human organism without medication means. The main means of the program were special blocks of swimming. We determined the demand in formation of person’s desire for further physical development, for accumulation knowledge and skills in correct selection and fulfillment of physical exercises; for independent controlling own physical fitness. Conclusions: In preparatory part we recommend to use the following blocks: warming up, breathing, theoretical block. In main part the following blocks were used: exercises with objects, imitation exercises, facilitating mastering swimming; jumps and exercises on ground; distant swimming; hypoxic exercises. In final part game and breathing exercises were used. It is recommended to use principle of variability, which envisages planning of training process in compliance with age-gender specificities.

  8. Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants

    Directory of Open Access Journals (Sweden)

    Muhammad Ayaz

    2017-05-01

    Full Text Available The use of essential oils (EOs and their components is known since long in traditional medicine and aromatherapy for the management of various diseases, and is further increased in the recent times. The neuroprotective and anti-aging potentials of EOs and their possible mechanism of actions were evaluated by numerous researchers around the globe. Several clinically important EOs and their components from Nigella sativa, Acorus gramineus, Lavandula angustifolia, Eucalyptus globulus, Mentha piperita, Rosmarinus officinalis, Jasminum sambac, Piper nigrum and so many other plants are reported for neuroprotective effects. This review article was aimed to summarize the current finding on EOs tested against neurodegenerative disorders like Alzheimer disease (AD and dementia. The effects of EOs on pathological targets of AD and dementia including amyloid deposition (Aβ, neurofibrillary tangles (NFTs, cholinergic hypofunction, oxidative stress and glutamatergic abnormalities were focused. Furthermore, effects of EOs on other neurological disorders including anxiety, depression, cognitive hypofunction epilepsy and convulsions were also evaluated in detail. In conclusion, EOs were effective on several pathological targets and have improved cognitive performance in animal models and human subjects. Thus, EOs can be developed as multi-potent agents against neurological disorders with better efficacy, safety and cost effectiveness.

  9. Gut microbiota: A player in aging and a target for anti-aging intervention.

    Science.gov (United States)

    Vaiserman, Alexander M; Koliada, Alexander K; Marotta, Francesco

    2017-05-01

    Aging-associated alterations in composition, diversity and functional features of intestinal microbiota are well-described in the modern literature. They are suggested to be caused by an age-related decline in immune system functioning (immunosenescence) and a low-grade chronic inflammation (inflammaging), which accompany many aging-associated pathologies. The microbiota-targeted dietary and probiotic interventions have been shown to favorably affect the host health and aging by an enhancement of antioxidant activity, improving immune homeostasis, suppression of chronic inflammation, regulation of fat deposition and metabolism and prevention of insulin resistance. Recently, a high effectiveness and safety of novel therapeutic application such as fecal microbiota transplantation in the prevention and treatment of age-related pathological conditions including atherosclerosis, type 2 diabetes and Parkinson's disease has been demonstrated. In this review, recent research findings are summarized on the role of gut micribiota in aging processes with emphasis on therapeutic potential of microbiome-targeted interventions in anti-aging medicine. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Bodacious Berry, Potency Wood and the Aging Monster: Gender and Age Relations in Anti-Aging Ads

    Science.gov (United States)

    Calasanti, Toni

    2007-01-01

    This paper situates age discrimination within a broader system of age relations that intersects with other inequalities, and then uses that framework to analyze internet advertisements for the anti-aging industry. Such ads reinforce age and gender relations by positing old people as worthwhile only to the extent that they look and act like those…

  11. Age transcended: a semiotic and rhetorical analysis of the discourse of agelessness in North American anti-aging skin care advertisements.

    Science.gov (United States)

    Ellison, Kirsten L

    2014-04-01

    Drawing from a collection of over 160 North American print advertisements for anti-aging skin care products from January to December of 2009, this paper examines the discourse of agelessness, a vision of esthetic perfection and optimal health that is continually referred to by gerontologists, cultural theorists, and scientific researchers as a state of being to which humankind can aspire. Employing critical discourse analysis through the use of semiotics and visual rhetoric, this paper explores the means through which anti-aging skin care advertisements present to their viewers a particular object of desire, looking, more specifically, at how agelessness is presented as a way out and ultimate transcendence of age. Through the analytical tools of semiotics and visual rhetoric, four visions of agelessness are identified and explored in this paper: Agelessness as Scientific Purity, Agelessness as Genetic Impulse, Agelessness as Nature's Essence, and Agelessness as Myth. Whether found in the heights of scientific purity, the inner core of our genetic impulse, the depths of nature's essence, or whether agelessness itself has reached its own, untouchable, mythic status, the advertisements in this study represent one of the most pervasive vehicles through which our current vision(s) of ageless perfection are reflected, reinforced, and suspended in a drop of cream. Copyright © 2013 The Author. Published by Elsevier Inc. All rights reserved.

  12. Chlorella sp : Extraction of fatty acid by using avocado oil as solvent and its application as an anti-aging cream

    Science.gov (United States)

    Putri, T. W.; Raya, I.; Natsir, H.; Mayasari, E.

    2018-03-01

    The study aimed to analyze the fatty acid content of Chlorella sp crude extract by using avocado oil solvent and determining the effectiveness of fatty acids Chlorella sp as the anti-aging cream The extraction of fatty acids from Chlorella sp using avocado oil as a solvent with three ratios were 1:10, 1:20 and 1:25 w/V. The highest lipid content was obtained at 1:20 w/V (gram microalgae: mL avocado oil) yielding 52.73%. Crude extracted were analysis by GC-MS and FTIR, and skin condition was determined by skin analyzer. The effectiveness test of Chlorella sp cream was applicated on the face of the panelists aged 20-60 years. From 10 panelists, the applied of Chlorella sp cream was 90% increased on the facial skin yielded moisture and oil content, 70% repair the skin structure. The composition of fatty acids Chlorella sp extract was palmitic acid, linoleic, oleic and stearate. Fatty acids crude extract of Chlorella sp can improve the effectiveness of anti-aging cream. The cream from Chlorella sp was more effective than the cream without containing microalgae. This is very promising because it is alternative to organic solvents i.e. green chemistry.

  13. In Search for Anti-Aging Strategy: Can We Rejuvenate Our Aging Stem Cells?

    Directory of Open Access Journals (Sweden)

    Anna Meiliana

    2015-08-01

    Full Text Available BACKGROUND: Recent evidence suggested that we grow old partly because of our stem cells grow old as a result of mechanisms that suppress the development of cancer over a lifetime. We believe that a further, more precise mechanistic understanding of this process will be required before this knowledge can be translated into human anti-aging therapies. CONTENT: A diminished capacity to maintain tissue homeostasis is a central physiological characteristic of aging. As stem cells regulate tissue homeostasis, depletion of stem cell reserves and/or diminished stem cell function have been postulated to contribute to aging. It has further been suggested that accumulated DNA damage could be a principal mechanism underlying age-dependent stem cell decline. It is interesting that many of the rejuvenating interventions act on the stem cell compartments, perhaps reflecting shared genetic and biochemical pathways controlling stem cell function and longevity. Strategy to slow down the aging processes is based on caloric restriction refers to a dietary regimen low in calories but without undernutrition. Sirtuin (SIRT1 and 3, increases longevity by mimicking the beneficial effects of caloric restriction. SIRT3 regulates stress-responsive mitochondrial homeostasis, and more importantly, SIRT3 upregulation rejuvenates aged stem cells in tissues. Resveratrol (3,5,4’-trihydroxystilbene, a natural polyphenol found in grapes and wine, was the most powerful natural activator of SIRT1. In fact, resveratrol treatment has been demonstrated to rescue adult stem cell decline, slow down bodyweight loss, improve trabecular bone structure and mineral density, and significantly extend lifespan. SUMMARY: Tissue-specific stem cells persist throughout the entire lifespan to repair and maintain tissues, but their self-renewal and differentiation potential become dysregulated with aging. Given that adult stem cells are thought to be central to tissue maintenance and organismal

  14. Institutions and Legitimations in Finance for the Arts

    DEFF Research Database (Denmark)

    Lunde Jørgensen, Ida

    of art support in the New Carlsberg Foundation and the Danish Arts Foundation at critical points in time, drawing on and contributing to the literature on institutional logics and convention theory. Specifically, the thesis shows the importance of nine particular logics of legitimation underlying art...... support; the industrial, market, inspired, family, renown, civic, projective, emotional and temporal. Most central to the foundations’ operation are the professional (industrial), artistic (inspired) and civic logics. The thesis shows that the invocations of these logics are highly reflective upon wider...

  15. Crime and Subjectivity: Reflections on the Discourses and Practices of Legitimizing Discriminatory Exercise of Criminal Law

    Directory of Open Access Journals (Sweden)

    Farah de Sousa Malcher

    2016-12-01

    Full Text Available We defend the importance of studying the discriminatory treatment of criminal law from the analysis of discourses on the subjectivities, resulting in dichotomy citizen/enemy. Rationalisations about the category of enemy in so-called "law of risk", seem to justify the unequal exercise of power punitive and the neutralization of individuals labelled as harmful and abnormal behavior, even if this is at the expense of principles, fundamental rights and guarantees of the rule of law. Such discourses also favors the neoliberal environment, to the extent that translate the entire conflitividade on punishment and legitimized stigmatization processes, criminalization of poverty and criminal selectivity.

  16. Smart meter data: Balancing consumer privacy concerns with legitimate applications

    International Nuclear Information System (INIS)

    McKenna, Eoghan; Richardson, Ian; Thomson, Murray

    2012-01-01

    Smart meters are being rolled out in large numbers throughout the world, with proponents claiming they are a critical step in the transition to a low-carbon economy. Yet there are significant unresolved negative reactions to smart meters, principally based on the concern that smart meters might be used to infer the private activities that occur within a dwelling. Though smart meter data is classified as personal data, and as such protected under existing data protection frameworks in the EU, there are relevant exceptions, notably where the data is required for legitimate applications associated with the performance of 'regulated duties'. This paper contributes to this debate by examining the data requirements for some of the proposed applications of smart meter data within the electricity supply industry, and investigates whether the use of personal data can be minimized or even avoided. The discussion includes system balancing, demand reduction, demand response and distribution network operation and planning, and indicates that, for most of these applications, the requirements for personal data can indeed be minimized. 'Privacy friendly' alternatives are discussed. - Highlights: ▶ Current smart meter systems provide a strong indication of occupancy. ▶ This will have important implications for external and internal home privacy. ▶ Personal data requirements within legitimate applications are discussed. ▶ 'Privacy friendly' techniques are suggested that minimize the use of personal data. ▶ Distribution network operator has strongest claim for data from each household.

  17. The Legitimation of Novel Technologies: The Case of Nanotechnology

    Science.gov (United States)

    Thyroff, Anastasia E.

    Nanotechnology is the control, manipulation, and application of matter on an atomic and molecular level. The technology is complex and confusing to consumers, and its long-term safety and effect on the human body, as well as the environment, are unknown. However, for the past decade, nanotechnology has been used to develop consumer products and food with novel and attractive attributes. Since nanotechnology is still not well known, it is not legitimized; that is, it has not been deemed safe and accepted by society. However, the market for nanotechnology is in the legitimation process. It will take an entire network of key stakeholders playing a specific roles for nanotechnology to legitimize. Specifically, each key stakeholder will align with a certain cultural discourse to frame nanotechnology in a particular way that complements their values. In Essay 1, I follow previous market system dynamic's literature and combine Actor Network Theory (ANT), Foucault's Discourse on Power and Goffman's Frame analysis to theoretically explore what the actor network for nanotechnology looks like. Four dominate frames are identified: 1) Advancement (i.e., government), 2) Management (i.e., industry), 3) Development (i.e., academia/scientists), and 4) Informant (i.e., NGO). Essay 2 empirically explores each actor's perspective on the nanotechnology network through a total of 24 interviews. A hermeneutic approach is used to analyze the 208 page text and themes describing each actor's role from a self and other's perspective are discussed. Additionally, three overarching themes (i.e., contradiction, constance, and cutoff) emerge; these themes describe the degree of similarity in how actors view their role in the nanotechnology network compared to how other actor's view that actor's role. In Essay 3, I bring critical theory into market system's research to better contextualize market formation theories. Specifically, I discuss how critical theory can be used to supplement ANT. I

  18. Screening of proteins based on macro-algae from West Java coast in Indonesian marine as a potential anti-aging agent

    Science.gov (United States)

    Putri, Arlina Prima; Dewi, Rizna Triana; Handayani, Aniek Sri; Harjanto, Sri; Chalid, Mochamad

    2018-02-01

    Algae has been known as one of the potential marine bio-resources that have been used in many fields such as bio-energy, food, pharmaceutical and medical applications. Study of macro-algae or seaweed for medicine application, in particular, highlights to empower their ingredients as a promising antioxidant like anti-aging agent due to their diversity in biological activity. The tropical climate of Indonesia with the highest marine biodiversity puts this country an auspicious source of numerous alga species as a novel antioxidant source. A Sample of 29 species of macroalgae has been collected from Coast of Pari Island as a part of Seribu Islands, Indonesia. Screening and extracting of aqueous tropical marine alga protein as a potential source for an antioxidant agent has been done by using 2,2-diphenyl-1-picrylhydrazyl scavenging method, and protein contents have been determined by Lowry method. Sample number 26 of the phylum Rhodophyta have 9.00±0.03 % protein content, which is potential for nutritional food in form of nutraceutical. That sample demonstrated the maximum DPPH scavenging activity 79.27±1.81 %. Moreover, crude extract from another species from phylum Rhodophyta had the very lower IC50 (3.4333±0.29 mg/ml) followed by Chlorophyta species (7.1069±1.78 mg/ml). In general, this study found that algae from phylum Rhodophyta possess a high content of protein, high activity towards free radical. Nevertheless, algae acquire the lowest IC50 value not only dominated by Rhodophyta but also from phylum Chlorophyta. The conclusion of this study leads to empowering high antioxidant activity algae as an anti-aging agent, which can be used in pharmaceutical applications. Therefore, the next study should be concerned on the properties of the algae which has been known to be suitable for pharmaceutical fields.

  19. Chronic mentally ill women: emergence and legitimation of program issues.

    Science.gov (United States)

    Bachrach, L L

    1985-10-01

    Program development for chronic mentally ill women is emerging in a climate where more general concerns relating to women's health and mental health are increasingly being examined. Although in the past the special needs of chronic mentally ill women have received scant attention in the professional literature, there is evidence today of a growing commitment to serving this population. The author traces the emergence and legitimation of three specific issues--homelessness, skills training, and family planning--that reflect the complexity of program development for this population. As specific issues in service delivery to chronic mentally ill women come to the fore and move toward relevant solutions, we may anticipate a sharpening of planning concepts. Both male and female chronic mental patients stand to benefit from these developments.

  20. Human Trafficking: Fighting the Illicit Economy with the Legitimate Economy

    Directory of Open Access Journals (Sweden)

    Louise Shelley

    2015-02-01

    Full Text Available Since the beginning of research on human trafficking, there has been attention paid to the challenges surrounding the illicit economy. In creating new strategies and initiatives on combatting human trafficking, there needs to be more discussion surrounding the legitimate economy and how the business sector can make an impact in the fight against trafficking. Currently, there is a growing movement of businesses that are looking to address human trafficking through training, education, and leadership initiatives; codes of conduct; supply chain management; and financial analysis. This paper will examine the latest in these strategies and approaches by businesses in the global war against human trafficking, in addition to a discussion of a new initiative engaging the private sector co-led by Dr. Louise Shelley and Christina Bain through the World Economic Forum’s Global Agenda Council Network.

  1. Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine.

    Science.gov (United States)

    Musshoff, F

    2000-02-01

    The interpretation of methamphetamine and amphetamine positive test results in biological samples is a challenge to clinical and forensic toxicology for several reasons. The effects of pH and dilution of urine samples and the knowledge about legitimate and illicit sources have to be taken into account. Besides a potentially legal prescription of amphetamines, many substances metabolize to methamphetamine or amphetamine in the body: amphetaminil, benzphetamine, clobenzorex, deprenyl, dimethylamphetamine, ethylamphetamine, famprofazone, fencamine, fenethylline, fenproporex, furfenorex, mefenorex, mesocarb, and prenylamine. Especially the knowledge of potential origins of methamphetamine and amphetamine turns out to be very important to prevent a misinterpretation of the surrounding circumstances and to prove illegal drug abuse. In this review, potential precursor compounds are described, including their medical use and major clinical effects and their metabolic profiles, as well as some clues which help to identify the sources.

  2. National HIV treatment guidelines in Tanzania and Ethiopia: are they legitimate rationing tools?

    Science.gov (United States)

    Johansson, K A; Jerene, D; Norheim, O F

    2008-06-01

    To provide an ethical analysis of whether the Ethiopian and Tanzanian national HIV/AIDS treatment guidelines can be considered legitimate and fair rationing tools. Qualitative study and ethical analysis involving guideline documents and interviews with nine key members involved in the development of the guidelines. The analysis followed an editing organising style. The theoretical framework was a guideline-specific framework based on theories of just resource allocation in healthcare and conditions that ensure fair processes in guideline development. According to this framework, legitimate rationing requires reasons for patient selection to be explicit, public and relevant, and decisions must be open to question and revision. The only explicit rationing criteria that both guidelines recommended were clinical antiretroviral treatment indications. Explicit non-clinical rationing criteria were expressed in a separate Ethiopian implementation guideline. Neither of the guideline development processes fully satisfies minimal requirements of procedural fairness. There is a lack of transparency. The reasons for decisions are rarely given and are not publicly available. This reduces the opportunity for public questioning, debate and revisions. The guidelines were based on expert opinion and consensus. Recommendations from the WHO were copied without much discussion, disagreement or adjustment. The two national HIV treatment guidelines discussed are de facto mechanisms for rationing but were developed using methods that do not fully satisfy the requirements of fair processes.

  3. Justificatory Rhetoric and Institutional Legitimation: A Case Study.

    Science.gov (United States)

    Francesconi, Robert

    To widen the concept of justificatory rhetoric (which has previously been considered as a presidential rhetorical form delivered in a context of foreign policy emergency) and to show some of its inherent hazards, this paper analyzes a 1978 address by Governor James Hunt of North Carolina, in which he justified his decision not to pardon the…

  4. Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage.

    Science.gov (United States)

    Avadhani, Kiran S; Manikkath, Jyothsna; Tiwari, Mradul; Chandrasekhar, Misra; Godavarthi, Ashok; Vidya, Shimoga M; Hariharapura, Raghu C; Kalthur, Guruprasad; Udupa, Nayanabhirama; Mutalik, Srinivas

    2017-11-01

    The present work attempts to develop and statistically optimize transfersomes containing EGCG and hyaluronic acid to synergize the UV radiation-protective ability of both compounds, along with imparting antioxidant and anti-aging effects. Transfersomes were prepared by thin film hydration technique, using soy phosphatidylcholine and sodium cholate, combined with high-pressure homogenization. They were characterized with respect to size, polydispersity index, zeta potential, morphology, entrapment efficiency, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), in vitro antioxidant activity and ex vivo skin permeation studies. Cell viability, lipid peroxidation, intracellular ROS levels and expression of MMPs (2 and 9) were determined in human keratinocyte cell lines (HaCaT). The composition of the transfersomes was statistically optimized by Design of Experiments using Box-Behnken design with four factors at three levels. The optimized transfersome formulation showed vesicle size, polydispersity index and zeta potential of 101.2 ± 6.0 nm, 0.245 ± 0.069 and -44.8 ± 5.24 mV, respectively. FTIR and DSC showed no interaction between EGCG and the selected excipients. XRD results revealed no form conversion of EGCG in its transfersomal form. The optimized transfersomes were found to increase the cell viability and reduce the lipid peroxidation, intracellular ROS and expression of MMPs in HaCaT cells. The optimized transfersomal formulation of EGCG and HA exhibited considerably higher skin permeation and deposition of EGCG than that observed with plain EGCG. The results underline the potential application of the developed transfersomes in sunscreen cream/lotions for improvement of UV radiation-protection along with deriving antioxidant and anti-aging effects.

  5. Anti-aging effect of adipose-derived stem cells in a mouse model of skin aging induced by D-galactose.

    Directory of Open Access Journals (Sweden)

    Shengchang Zhang

    Full Text Available INTRODUCTION: Glycation products accumulate during aging of slowly renewing tissue, including skin, and are suggested as an important mechanism underlying the skin aging process. Adipose-derived cells are widely used in the clinic to treat ischemic diseases and enhance wound healing. Interestingly, adipose-derived stem cells (ASCs are also effective in anti-aging therapy, although the mechanism underlying their effects remains unknown. The purpose of the present study was to examine the anti-aging effect of ASCs in a D-galactose-induced aging animal model and to clarify the underlying mechanism. MATERIALS AND METHODS: Six-week-old nude mice were subcutaneously injected with D-gal daily for 8 weeks. Two weeks after completion of treatment, mice were randomized to receive subcutaneous injections of 106 green fluorescent protein (GFP-expressing ASCs, aminoguanidine (AG or phosphate-buffered saline (PBS. Control mice received no treatment. We examined tissue histology and determined the activity of senescence-associated molecular markers such as superoxide dismutase (SOD and malondialdehyde (MDA. RESULTS: Transplanted ASCs were detectable for 14 days and their GFP signal disappeared at day 28 after injection. ASCs inhibited advanced glycation end product (AGE levels in our animal model as well as increased the SOD level and decreased the MDA level, all of which act to reverse the aging phenotype in a similar way to AG, an inhibitor of AGE formation. Furthermore, ASCs released angiogenic factors in vivo such as vascular endothelial growth factor, suggesting a skin trophic effect. CONCLUSIONS: These results demonstrate that ASCs may contribute to the regeneration of skin during aging. In addition, the data shows that ASCs provide a functional benefit by glycation suppression, antioxidation, and trophic effects in a mouse model of aging.

  6. The principle of legitimate expectations in Dutch constitutional and administrative law

    NARCIS (Netherlands)

    Berge, Gio ten; Widdershoven, R.J.G.M.

    1998-01-01

    “An important function of the law is to provide certainty by making possible legitimate expectations”.1 “The law cannot be based on trust and expectations, however reasonable and fair they may be”.2 These are just two quotations from Dutch literature on the principle of legitimate

  7. When legitimate claims collide: communities, media and dialogue

    Directory of Open Access Journals (Sweden)

    Klas Grinell

    2015-04-01

    Full Text Available This paper discusses the exhibition Jerusalem at the Museum of World Culture (MoWC in Gothenburg, Sweden. The exhibition mixes photographs of LGBTQ (LesbianGayBiTransQueer persons in Jerusalem, with quotes from the three Abrahamitic Holy Scriptures condemning homosexual activities and behaviours. MoWC held dialogues with religious persons. Although no-one wanted to stop the exhibition, many were critical of the artist’s mixing of Holiness and Nudity/Sexuality. The Museum was criticized for bending to fundamentalist pressure, assuming that it had plans to stop the exhibition, and a media debate on censorship and freedom of speech followed. This paper analyzes the situatedness of MoWC, and its discursive belonging. How can a state governed institution deal with legitimate and opposing claims, and counter both heteronormativity and islamophobia? What discourses is the Museum institution inscribed in? What power relations follow from that? Is it, due to historic, bureaucratic, and cultural legacies, tied to certain positions and affiliations in the public space?

  8. Legitimizing Private Actors in Global Governance: From Performance to Performativity

    Directory of Open Access Journals (Sweden)

    Elke Krahmann

    2017-03-01

    Full Text Available Global governance is frequently criticised because of major legitimacy deficits, including lack of public accountability and democratic control. Within this context, questions about the legitimacy of non-state governance actors, such as non-governmental organizations, transnational corporations and private security companies, are neither an exception nor a surprise. Many actors have, therefore, turned to the measurement of performance, defined as publicly beneficial outcomes, in order to gain legitimacy. However, the rise of performance assessments as legitimizing practice is not without problems. Taking global security and health interventions as examples, this article contends that the immaterial, socially constructed and inherently contested nature of such public goods presents major obstacles for the assessment of performance in terms of observable, measurable and attributable outcomes. Performance is therefore frequently replaced by performativity, i.e. a focus on the repetitive enactment of specific forms of behaviour and capabilities, which are simply equated with the intended results. The implications for how global public goods are conceptualized and, ultimately, implemented are profound.

  9. LEGITIMATION DOCUMENTS ISSUED BY THE FRENCH MINISTRY OF FOREIGN AFFAIRS

    CERN Multimedia

    2003-01-01

    The French Ministry of Foreign Affairs (hereinafter referred to as "MAE") has sent a reminder of the following rules relating to legitimation documents (special cards, henceforth called "special residence permits" (titres de séjour spéciaux), and attestations de fonctions) that it issues. The Ministry has specified that compliance with these rules is essential to the proper functioning of any International Organization established in France. 1. Types of document and use a) Special CD, FI and AT residence permits They serve as residence permits for members of the personnel and the members of their families who are not of French nationality and who do not have the status of permanent resident (see N.B. below). Vis-à-vis the French authorities, they serve as proof that those holding these cards enjoy the privileges and immunities provided for by the Status Agreement between CERN and France (immunity from legal process in the discharge of their duties, entitlement to drive a vehicle registered in a special ...

  10. Legitimation documents issued by the French Ministry of Foreign Affairs

    CERN Multimedia

    2006-01-01

    New rules and reminder The French Ministry of Foreign Affairs (hereinafter referred to as 'MAE') has informed CERN of the following solution to a problem that has existed for over 30 years: from now on, members of the personnel residing in France and holding a full-time contract of between three and six months will be entitled to a special EM-type residence permit that does not confer any privileges (see Paragraph 2 below). Furthermore, the MAE has stated that it is willing to request the competent authorities to look favourably on applications for work permits by a member of the personnel's family members who reside in France and wish to take up gainful employment, although it is unable to guarantee the outcome (see Paragraph 7 below). The MAE also wishes to draw attention to the following rules concerning the legitimation documents it issues and to point out that compliance with these rules is essential for the proper operation of all international organisations established in France. This communicatio...

  11. Biofuels are (Not the Future! Legitimation Strategies of Sustainable Ventures in Complex Institutional Environments

    Directory of Open Access Journals (Sweden)

    Neil A. Thompson

    2018-04-01

    Full Text Available Sustainable ventures often lack legitimacy (perceived to be desirable and appropriate because various stakeholder groups use contradictory institutions (rules and norms to make their judgements, which leads to there being fewer resources available and higher failure rates. Using an institutional theory framework and a multi-case research design with 15 biofuel ventures operating in the Netherlands, this study asks how sustainable entrepreneurs attempt to gain legitimacy in these circumstances. Analysis reveals that the entrepreneurs use a combination of rhetorical, reconciliatory and institutional change strategies to obtain legitimacy from different stakeholder groups. These findings further our understanding of sustainable entrepreneurial behavior by revealing how and why different legitimation strategies are used in complex institutional environments.

  12. Remarks on the Legitimate Use of Force to Defend the Environment

    Directory of Open Access Journals (Sweden)

    Luciano Pereira de Souza

    2016-10-01

    Full Text Available This article evaluates whether the legitimate defense can be used in the protection of collective environmental rights. Some scholars are contrary to the legitimate defense of those rights in face of an unlawful assault not involving concomitant aggression to individual rights. Given the current risk scenario for the global ecological balance, revealed by the approach of planetary boundaries - and taking into account its fundamental principles of protection and defense of a right – this paper does not exclude legitimate defense as a lawful means of environmental protection, regardless its impact on public order and peace.

  13. Legitimate family violence as represented in the print media: textual analysis.

    Science.gov (United States)

    Redman, Susan; Taylor, Julie

    2006-10-01

    This paper reports a study of how issues around the use of smacking by parents are represented in the print media. Our purpose was not to state a case for or against the use of smacking. Rather, within the contemporary social context we sought to answer the question, 'Why is smacking considered to be a legitimate part of parenting in the United Kingdom?' Although a number of government proposals aiming to ban the use of smacking by parents have been presented in the United Kingdom parliament and Scottish Executive, current legislation allows parents to use this form of physical discipline as long as it does not result in physical injury to the child. For the purposes of this discussion, smacking is considered as a social phenomenon rather than an activity simply to be favoured or to be opposed. A sample of 244 articles from five different United Kingdom newspapers was examined during 2004. Schema analysis that drew upon semiotics was used to analyse these print media representations about the use of legitimate violence by parents towards children. Newspaper reportage about the parental use of physical discipline has increased over the past 20 years. Only one newspaper (The Independent) published on this topic prior to 1994. The discourse about the use of physical discipline by parents has changed over time from one that focuses on the effectiveness of smacking to one that about the human rights of the child. The main themes identified in the print media discourse were the rights of the child, the effectiveness of smacking, long-term effects and consequences, and the role of the state. Media texts can influence and reinforce social dimensions of the label. The beliefs and attitudes of healthcare professionals and parents about smacking may be influenced by such representations.

  14. Legitimering gjennom (selektiv felles fortid: russisk bruk av historie i Ukraina-konflikten

    Directory of Open Access Journals (Sweden)

    Minda Holm

    2016-12-01

    Full Text Available Abstract: Legitimation Through a (Selective Shared Past: Russia's Use of History in the Conflict in UkraineHow has Russia used history to justify its actions in the conflict in Ukraine? Through an analysis of official statements of the Ministry of Foreign Affairs, as well as speeches and remarks by Putin, this article argues that history has played an important but varying role in official rhetoric. With Crimea, the emphasis was on the ‘sanctity’ of the territory for Russian Orthodox identity, drawing on history dating back to the baptism of Prince Vladimir in 10th century AC. The shared past of the two states has not been as central in official Russian policy justification regarding Ukraine outside Crimea: the ‘brotherhood’ of the two nations has been noted repeatedly, but usually secondary to arguments pertaining to economic and political interests. The two world wars have been used as a cautionary tale, with Russia effectively seeking to delegitimize the new Ukrainian government by evoking carefully selected elements of its past. Finally, the author looks at the use of international precedence as a form of justification, turning the history of Western – US in particular – actions back on Russia’s critics. The official usage of history is placed within broader strategies of legitimation, as it is not enough to study propaganda and manipulation strategies as part of information warfare to explain how the Kremlin achieves support for its policies. The ‘thick’ historical narratives of Crimea play on elements linked to issues of national identity, making it difficult to dispute using the type of counter-propaganda and rebuttal of disinformation proposed by some.

  15. Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application.

    Science.gov (United States)

    Zhao, Pan; Sui, Bing-Dong; Liu, Nu; Lv, Ya-Jie; Zheng, Chen-Xi; Lu, Yong-Bo; Huang, Wen-Tao; Zhou, Cui-Hong; Chen, Ji; Pang, Dan-Lin; Fei, Dong-Dong; Xuan, Kun; Hu, Cheng-Hu; Jin, Yan

    2017-10-01

    Cutaneous wounds are among the most common soft tissue injuries and are particularly hard to heal in aging. Caloric restriction (CR) is well documented to extend longevity; pharmacologically, profound rejuvenative effects of CR mimetics have been uncovered, especially metformin (MET), resveratrol (RSV), and rapamycin (RAPA). However, locally applied impacts and functional differences of these agents on wound healing remain to be established. Here, we discovered that chronic topical administration of MET and RSV, but not RAPA, accelerated wound healing with improved epidermis, hair follicles, and collagen deposition in young rodents, and MET exerted more profound effects. Furthermore, locally applied MET and RSV improved vascularization of the wound beds, which were attributed to stimulation of adenosine monophosphate-activated protein kinase (AMPK) pathway, the key mediator of wound healing. Notably, in aged skin, AMPK pathway was inhibited, correlated with impaired vasculature and reduced healing ability. As therapeutic approaches, local treatments of MET and RSV prevented age-related AMPK suppression and angiogenic inhibition in wound beds. Moreover, in aged rats, rejuvenative effects of topically applied MET and RSV on cell viability of wound beds were confirmed, of which MET showed more prominent anti-aging effects. We further verified that only MET promoted wound healing and cutaneous integrity in aged skin. These findings clarified differential effects of CR-based anti-aging pharmacology in wound healing, identified critical angiogenic and rejuvenative mechanisms through AMPK pathway in both young and aged skin, and unraveled chronic local application of MET as the optimal and promising regenerative agent in treating cutaneous wound defects. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  16. Anti-Aging Effects of Hippophae rhamnoides Emulsion on Human Skin

    African Journals Online (AJOL)

    Purpose: This study aimed to evaluate the effects of topically applied water-in-oil (w/o) emulsion of Hippophae rhamnoides using standard R cutometer parameters. Methods: A w/o emulsion of 1 % hydro-alcoholic extract of H. rhamnoides (formulation) and placebo control (base) were used in the study. Eleven healthy male ...

  17. Anti-aging potential of a cream containing milk thistle extract ...

    African Journals Online (AJOL)

    The evaluation parameters consisted of colour, smell, type of emulsion, electrical conductivity, liquefaction and pH. The expected organoleptic stability of creams was acheived from 8 weeks in-vitro study period. The formulation and base were evaluated for effects on skin moisture and transepidermal water loss (TEWL).

  18. Anti-Aging Effect of Riboflavin Via Endogenous Antioxidant in Fruit fly Drosophila Melanogaster.

    Science.gov (United States)

    Zou, Y-X; Ruan, M-H; Luan, J; Feng, X; Chen, S; Chu, Z-Y

    2017-01-01

    This study investigated the effect of riboflavin on aging in Drosophila melanogaster (fruit fly). Experimental study. Naval Medical Research Institute. Fruit fly Drosophila melanogaster. After lifelong supplement of riboflavin, the lifespan and the reproduction of fruit flies were observed. Hydrogen peroxide (H2O2) was used to mimic oxidative stress damage to fruit flies and the survival time was recorded. The activity of copper-zinc-containing superoxide dismutase (SOD1), manganese containing SOD (SOD2) and catalase (CAT) and lipofuscin (LF) content were determined. Riboflavin significantly prolonged the lifespan (Log rank χ2=16.677, Priboflavin supplement. Riboflavin prolonged the lifespan and increased the reproduction of fruit flies through anti-oxidative stress pathway involving enhancing the activity of SOD1 and CAT and inhibiting LF accumulation. Riboflavin deserves more attention for slowing human aging.

  19. Health, physical exercise and fear of aging: anti-aging problematizations in amateur bodybuilders speeches

    OpenAIRE

    Teixeira, Fábio Luís Santos; Caminha, Iraquitan de Oliveira

    2017-01-01

    Scientific arguments in favour of applying physical exercise as an intervention on "aging" insists on relying on the biological concept of health. Considering the hegemony of this concept in physical education, the present study questions in what extent it must be accepted that the relationship between health/aging remains summarized in the mere search for maintaining physiological capabilities? The aim was to analyse the problematizations on the relationship between health and exercise in a ...

  20. Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery.

    Science.gov (United States)

    Shen, Chun-Yan; Jiang, Jian-Guo; Yang, Li; Wang, Da-Wei; Zhu, Wei

    2017-06-01

    Ageing, an unanswered question in the medical field, is a multifactorial process that results in a progressive functional decline in cells, tissues and organisms. Although it is impossible to prevent ageing, slowing down the rate of ageing is entirely possible to achieve. Traditional Chinese medicine (TCM) is characterized by the nourishing of life and its role in anti-ageing is getting more and more attention. This article summarizes the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades. The effective anti-ageing ingredients identified can be generally divided into flavonoids, saponins, polysaccharides, alkaloids and others. Astragaloside, Cistanche tubulosa acteoside, icariin, tetrahydrocurcumin, quercetin, butein, berberine, catechin, curcumin, epigallocatechin gallate, gastrodin, 6-Gingerol, glaucarubinone, ginsenoside Rg1, luteolin, icarisid II, naringenin, resveratrol, theaflavin, carnosic acid, catalpol, chrysophanol, cycloastragenol, emodin, galangin, echinacoside, ferulic acid, huperzine, honokiol, isoliensinine, phycocyanin, proanthocyanidins, rosmarinic acid, oxymatrine, piceid, puerarin and salvianolic acid B are specified in this review. Simultaneously, chemical structures of the monomers with anti-ageing activities are listed, and their source, model, efficacy and mechanism are also described. The TCMs with anti-ageing function are classified according to their action pathways, including the telomere and telomerase, the sirtuins, the mammalian target of rapamycin, AMP-activated kinase and insulin/insulin-like growth factor-1 signalling pathway, free radicals scavenging and the resistance to DNA damage. Finally, Chinese compound prescription and extracts related to anti-ageing are introduced, which provides the basis and the direction for the further development of novel and potential drugs. This article is part of a themed section on Principles of Pharmacological Research of

  1. Heptapeptide-loaded solid lipid nanoparticles for cosmetic anti-aging applications.

    Science.gov (United States)

    Suter, Franz; Schmid, Daniel; Wandrey, Franziska; Zülli, Fred

    2016-11-01

    The cosmetic industry requires more and more expensive actives and ingredients such as retinol, coenzyme Q10, proteins, peptides and biotechnologically produced molecules. In this study, we demonstrate the development of a cost effective formulation of a nanostructured lipid carrier (NLC) or solid lipid nanoparticles (SLN) improving peptide delivery into skin. NLC or SLN are very suitable vehicles for the delivery of active ingredients into skin. The SLN, produced by using hot high pressure homogenization method combine advantages such as physical stability, protection of incorporated labile actives and controlled release. By the used method we dispersed the amorphous heptapeptide DEETGEF in shea butter and homogenized this pre-dispersion at 60°C together with the water phase using a Microfluidizer at 1000bar. The analysis of the obtained SLN-P7 showed a particle size of 173nm, incorporated peptide of 0.014%, entrapment efficiency of 90.8%, melting peak (DSC) of the core lipid of 27°C and a zeta potential of -54mV. By an ex vivo study with skin explants we could stimulate NQO1 (NAD(P)H quinone oxidoreductase), HMOX1 (Heme oxygenase-1) and PRDX1 (Peroxiredoxin-1) genes all of which are cell protecting enzymes. In a multicellular protection against UV induced stress study with skin explants we detected the formation of sun burn cells and the number and morphology of Langerhans cells. The application of our SLN-P7 formulation on skin explants led to a significant and dose dependent protection against UV irradiation. In the clinical suction blister study, irradiation with UVA light for two hours after final product application led to a statistically significant increase of the 8-OhdG (8-hydroxy-2'-deoxyguanosine) concentration in the human epidermis. The skin treated with our verum formulation showed a statistically significant 20% decrease in DNA damage compared to placebo. In conclusion, it was demonstrated that SLN technology enabled peptide delivery into skin

  2. Health, physical exercise and fear of aging: anti-aging problematizations in amateur bodybuilders speeches

    Directory of Open Access Journals (Sweden)

    Fábio Luís Santos Teixeira

    2017-09-01

    Full Text Available Scientific arguments in favour of applying physical exercise as an intervention on "aging" insists on relying on the biological concept of health. Considering the hegemony of this concept in physical education, the present study questions in what extent it must be accepted that the relationship between health/aging remains summarized in the mere search for maintaining physiological capabilities? The aim was to analyse the problematizations on the relationship between health and exercise in a group of physically active women from the city of Recife, Pernambuco, Brazil, in the context of aging process. Forty-five amateur bodybuilders were selected utilizing the sample snowball technique. They answered an interview guide with pictures according to the photo elicitation technique, individually. It was utilized the speech analysis proposed by Foucault. The group understands the relationship health/aging as a way to build identities, overcoming the negative perception of old age as vital and negative process. The fear of aging denotes the presence of self-centred healthcare practices carried over the years. Physical exercise plays a role that transcends the mere control of biological variables, being a resource to strengthen the experience to look and feel younger.

  3. Combined anti-ages and antioxidant activities of different solvent extracts of Solanum elaeagnifolium Cav (Solanacea) fruits during ripening and related to their phytochemical compositions

    Science.gov (United States)

    Houda, Mejri; Derbré, Séverine; Jedy, Ahmed; Tlili, Nizar; Legault, Jean; Richomme, Pascal; Limam, Ferid; Saidani-Tounsi, Moufida

    2014-01-01

    Oxidative stress and advanced glycation end products (AGEs) are known as key factors for the development of diabetic complications such as retinopathy, cataract as well as atherosclerosis and neurodegenerative diseases, including Alzheimer’s diseases. In this context, natural products have been previously identified as promising sources for antioxidant and anti-glycation compounds. The current study focuses on the evaluation of antioxidant and glycation inhibitory activities of different solvent extracts of Solanum elaeagnifolium Cav (Solanaceae) fruits at different ripening stages. The results showed that antioxidant and anti-AGEs activities were significantly influenced by solvents polarities and ripening stages of S. elaeagnifolium Cav. With one exception, methanolic extract of overripe S. elaeagnifolium Cav fruit showed important protective effects against cellular oxidative stress. The aqueous extract showed the highest ABTS+ scavenging ability. Principal component analysis showed that total phenolic and flavonoid contents correlated well with observed antioxidants and anti-glycation activities. These results bring attention to the possible use of S. elaeagnifolium Cav as a valuable source of bioactive compounds exhibiting antioxidant effects and potentially alleviating diabetic complications. PMID:26417319

  4. A Novel Cassia fistula (L.-Based Emulsion Elicits Skin Anti-Aging Benefits in Humans

    Directory of Open Access Journals (Sweden)

    Barkat Ali Khan

    2015-11-01

    Full Text Available Cassia fistula, a flowering plant in the family of Caesalpinaceae (Fabaceae, is used in traditional medicine for several indications. Nevertheless, too little is known about its effects on skin conditions and skin aging. Therefore, in this pioneering study, the extracts of oil-in-water macro-emulsions containing 5% C. fistula (L. crude pods (i.e., phyto-active formulation were optimally developed and compared to the placebo (i.e., emulsions without the crude extract for assessment of their effects on human skin aging. Healthy adult male volunteers (n = 13 with a mean age of 31 ± 5.5 years (range: 24–47 years were enrolled after informed written consent. For 12 consecutive weeks, the subjects were directed to use a patch containing the active emulsion on one of their forearms as well as a patch containing the placebo on their other forearm. Biometrological measurements of skin hydration (SH and transepidermal water loss (TEWL were performed on both sides of their respective cheeks at time 0 (baseline values, 2, 4, 6, 8, 10 and 12th weeks. Surface evaluation of living skin (SELS was taken at time 0 (baseline values or after 1, 2 and 3 months. Topical application of C. fistula extracts showed a significant (p < 0.05 increase in stratum corneum hydration level, a significant enhancement in its water-holding function as well as in its barrier function. Further, significant (p < 0.005 ameliorations of skin aspects were observed (i.e., less roughness, less dryness, less wrinkles. Taken together, our results strongly suggest therapeutic and esthetic potential of C. fistula pod’s extracts to prevent or delay human skin aging.

  5. Does the Sole Description of a Tax Authority Affect Tax Evasion? - The Impact of Described Coercive and Legitimate Power

    Science.gov (United States)

    Hartl, Barbara; Hofmann, Eva; Gangl, Katharina; Hartner-Tiefenthaler, Martina; Kirchler, Erich

    2015-01-01

    Following the classic economic model of tax evasion, taxpayers base their tax decisions on economic determinants, like fine rate and audit probability. Empirical findings on the relationship between economic key determinants and tax evasion are inconsistent and suggest that taxpayers may rather rely on their beliefs about tax authority’s power. Descriptions of the tax authority’s power may affect taxpayers’ beliefs and as such tax evasion. Experiment 1 investigates the impact of fines and beliefs regarding tax authority’s power on tax evasion. Experiments 2-4 are conducted to examine the effect of varying descriptions about a tax authority’s power on participants’ beliefs and respective tax evasion. It is investigated whether tax evasion is influenced by the description of an authority wielding coercive power (Experiment 2), legitimate power (Experiment 3), and coercive and legitimate power combined (Experiment 4). Further, it is examined whether a contrast of the description of power (low to high power; high to low power) impacts tax evasion (Experiments 2-4). Results show that the amount of fine does not impact tax payments, whereas participants’ beliefs regarding tax authority’s power significantly shape compliance decisions. Descriptions of high coercive power as well as high legitimate power affect beliefs about tax authority’s power and positively impact tax honesty. This effect still holds if both qualities of power are applied simultaneously. The contrast of descriptions has little impact on tax evasion. The current study indicates that descriptions of the tax authority, e.g., in information brochures and media reports, have more influence on beliefs and tax payments than information on fine rates. Methodically, these considerations become particularly important when descriptions or vignettes are used besides objective information. PMID:25923770

  6. Does the sole description of a tax authority affect tax evasion?--the impact of described coercive and legitimate power.

    Science.gov (United States)

    Hartl, Barbara; Hofmann, Eva; Gangl, Katharina; Hartner-Tiefenthaler, Martina; Kirchler, Erich

    2015-01-01

    Following the classic economic model of tax evasion, taxpayers base their tax decisions on economic determinants, like fine rate and audit probability. Empirical findings on the relationship between economic key determinants and tax evasion are inconsistent and suggest that taxpayers may rather rely on their beliefs about tax authority's power. Descriptions of the tax authority's power may affect taxpayers' beliefs and as such tax evasion. Experiment 1 investigates the impact of fines and beliefs regarding tax authority's power on tax evasion. Experiments 2-4 are conducted to examine the effect of varying descriptions about a tax authority's power on participants' beliefs and respective tax evasion. It is investigated whether tax evasion is influenced by the description of an authority wielding coercive power (Experiment 2), legitimate power (Experiment 3), and coercive and legitimate power combined (Experiment 4). Further, it is examined whether a contrast of the description of power (low to high power; high to low power) impacts tax evasion (Experiments 2-4). Results show that the amount of fine does not impact tax payments, whereas participants' beliefs regarding tax authority's power significantly shape compliance decisions. Descriptions of high coercive power as well as high legitimate power affect beliefs about tax authority's power and positively impact tax honesty. This effect still holds if both qualities of power are applied simultaneously. The contrast of descriptions has little impact on tax evasion. The current study indicates that descriptions of the tax authority, e.g., in information brochures and media reports, have more influence on beliefs and tax payments than information on fine rates. Methodically, these considerations become particularly important when descriptions or vignettes are used besides objective information.

  7. [From the right to health to the responsibility for healthy aging: a new foundation for anti-aging medicine in Germany].

    Science.gov (United States)

    Spindler, M

    2010-03-01

    This paper explores the problem of dealing with normalisation in public health concepts, using the example of the relaunching of anti-aging-medicine in Germany. The analysis mainly draws upon qualitative analyses of publications of different anti-aging-medicine organisations. The German branch of anti-aging-medicine's new concepts of the nature, the morality and the self-design of aging are delineated. These are the concepts of aging as a medically controllable health risk (nature), the emphasis of the moral duty to responsible personal risk control (morality) and the self-design through individual risk profiles and prevention programmes. The analysis shows that the proposed bio-political programme cannot only be induced from biologically, societally or medically given facts, but that it is - as all public health concepts - a normative concept. It is argued that the normative aspects of public health concepts cannot be avoided but should be explicated and negotiated. This paper therefore concludes with an exploration of what there is to negotiate concerning the German anti-aging-physicians' surprisingly uncontroversial plea for a shift of emphasis from the collective right to health to a new individual duty for health maintenance in old age. Georg Thieme Verlag KG Stuttgart. New York.

  8. Anti-Oxidant, Anti-Aging, and Anti-Melanogenic Properties of the Essential Oils from Two Varieties of Alpinia zerumbet

    Directory of Open Access Journals (Sweden)

    Pham Thi Be Tu

    2015-09-01

    Full Text Available Here, we investigated the anti-oxidant and anti-aging effects of essential oils (EOs from the leaves of Alpinia zerumbet (tairin and shima in vitro and anti-melanogenic effects in B16F10 melanoma cells. The anti-oxidant activities were performed with 2,2-diphenyl-1-picrylhydrazyl (DPPH; 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid diammonium salt (ABTS; nitric oxide; singlet oxygen; hydroxyl radical scavenging; and xanthine oxidase. The inhibitory activities against collagenase, elastase, hyaluronidase, and tyrosinase were employed for anti-aging. The anti-melanogenic was assessed in B16F10 melanoma cells by melanin synthesis and intracellular tyrosinase inhibitory activity. The volatile chemical composition of the essential oil was analyzed with gas chromatography-mass spectrometry (GC/MS. The EO was a complex mixture mainly consisting of monoterpenes and sesquiterpenes. The results revealed that tairin and shima EOs showed strong anti-oxidant activities against DPPH and nitric oxide, hydroxyl radical scavenging activity, and xanthine oxidase inhibition. Compared to shima EO; tairin EO exhibited strong anti-aging activity by inhibiting collagenase, tyrosinase, hyaluronidase, and elastase (IC50 = 11 ± 0.1; 25 ± 1.2; 83 ± 1.6; and 213 ± 2 μg/mL, respectively. Both EOs inhibited intracellular tyrosinase activity; thus, reducing melanin synthesis. These results suggest that tairin EO has better anti-oxidant/anti-aging activity than shima EO, but both are equally anti-melanogenic.

  9. Learning to listen. Institutional change and legitimation in UK radioactive waste policy

    Energy Technology Data Exchange (ETDEWEB)

    Mackerron, G. [SPRU Science and Technology Policy Research, University of Sussex, Brighton (United Kingdom); Berkhout, F. [Institute for Environmental Studies IVM, VU University, Amsterdam (Netherlands)

    2009-04-15

    Over the course of 50 years, UK radioactive waste policy change has been coupled with institutional change, without much progress towards the ultimate goal of safe, long-term stewardship of wastes. We explain this history as a search for legitimacy against a shifting context of legitimation needs and deficits. Following Habermas, we argue that legitimation is derived from a process of justificatory discourse. In principle, there must be a reasonable exchange of arguments between diverse parties in society, based on common norms, for legitimacy to be achieved. We show that the work of legitimation in UK radioactive waste policy has moved from a focus on factual validity claims towards an increasing emphasis on deliberative processes. This reframing of legitimation needs explains institutional and policy changes in UK radioactive waste policy. The most recent phase of policy and institutional change, which placed public deliberation about long-term management and disposal options centre-stage, represents a new step towards bridging legitimation deficits. Plans to build new nuclear reactors in the UK based on a more closed 'streamlined' decision process risk reversing the legitimacy gains that have been achieved through growing openness on radioactive waste management.

  10. Legitimate Peripheral Participation as a Framework for Conversation Analytic Work in Second Language Learning

    Directory of Open Access Journals (Sweden)

    Gitte Rasmussen Hougaard

    2009-03-01

    Full Text Available Since its inception, Conversation Analysis (CA has become not only a framework and a set of methods for studying the generic machinery of talk-in-interaction but also a celebrated, qualitative method for studying a wealth of phenomena and exploring and testing concepts and hypotheses from numerous disciplines, including linguistics, psychology, anthropology and Second Language Acquisition (SLA. CA is often resorted to as the key to resolving knots and dead-ends in these neighboring disciplines. Despite the very interesting results that such work admittedly produces, it is too often not accompanied by focused considerations of how the specific concerns from one field match with the aims that CA procedures have been developed for and hence with the procedures themselves. This paper takes recent applications of CA to the study of SLA as a case in point. It discusses a whether CA can shed light on "learning" as commonly defined in SLA and b whether the resort to a particular model of learning (LAVE & WENGER, 1991, Legitimate Peripheral Participation (LPP helps overcoming some of the problems with which CA work in SLA is confronted. It is hoped that the specific discussions of problems involved in the project, CA-for-SLA, will contribute to the ongoing, general discussion of qualitative research methods and their prospects and problems. URN: urn:nbn:de:0114-fqs090247

  11. Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2.

    Science.gov (United States)

    Tang, Wen-Zhao; Wang, Ying-Ai; Gao, Tian-Yang; Wang, Xiao-Jing; Zhao, Yun-Xue

    2017-05-01

    The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C (1) and five known C-geranylated flavanones (2-6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH 2 Cl 2 extract of P. catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H 2 O 2 . Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C-geranylated flavonoids. Diplacone (3) and paucatalinone A (5) were the potent anti-aging agents in the premature senescent 2BS cells induced by H 2 O 2 and the C-geranyl substituent may be an important factor because of its lipophilic character. Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  12. Medical pluralism and medical marginality: bone doctors and the selective legitimation of therapeutic expertise in India.

    Science.gov (United States)

    Lambert, Helen

    2012-04-01

    Current health policy initiatives in India advocate medical pluralism and seek to address a lack of skilled human resources for health care provision. This qualitative study investigated a form of indigenous therapy that does not fit into officially recognised categories of 'Indian medicine' but is a popular source of informal medical care. Semi-structured interviews and ethnographic observations of 30 'bone doctor' (haad vaidya) practices were conducted in the capital city of Rajasthan, north India in 2009-2010 together with historical analysis of changes in state policies for the registration of Indian medicine practitioners. Contestations over legitimacy among individual practitioners and hierarchies of authority between different medical traditions are shown to rest on conceptions of what constitutes authentic 'expertise'. The findings demonstrate a progressive restriction over time in official definitions of medical expertise, towards a reliance exclusively on formal qualifications rather than experientially acquired and inherited skills to demarcate legitimate therapeutic knowledge. This case study contributes to our understanding of the nature of non-professional expertise and its implications for pluralistic health care policy and the human resourcing of Indian health systems. Copyright © 2012 Elsevier Ltd. All rights reserved.

  13. The mechanisms of constitutional reform in and the legitimation of the peace agreements

    Directory of Open Access Journals (Sweden)

    José Luis Sañudo Ospina

    2017-03-01

    Full Text Available The Colombian state is about to close one of the worst chapters in its history: the war against FARC (Revolutionary Armed Forces of Colombia that has lasted for more than five decades. After more than three years of discussions, the parties have settled on important agreements such as the de-escalation of the armed conflict and transitional justice mechanisms. It is thus time for the State to use constitutional and legal means to incorporate the agreements into the national legal system. President Juan Manuel Santos has called for a plebiscite as the means to legitimate the peace agreements. As a surprise to many, the plebiscite did not obtain the votes needed for its implementation, leaving it’s future in uncertainty. The government is now considering other alternatives, such as pass it through congress, call for an open council meeting and even call for a new plebiscite. The main aim of this article is to analyze the mechanisms of constitutional reform existing in the Colombian legal system to validate the Havana Talks. Some concepts, and constitutional and legal regulations will be studied and various mechanisms of citizen participation and constitutional reform will be contrasted that may help to achieve the government expectations with the peace process.

  14. Radioisotopes "economy of promises": on the limits of biomedicine in public legitimization of nuclear activities.

    Science.gov (United States)

    Boudia, Soraya

    2009-01-01

    This paper aims to examine the rise and the fall of biomedicine in the public legitimization of the development of nuclear energy. Until the late 1950s, biological and medical applications of radioisotopes were presented as the most important successes of the peaceful uses of atomic energy. I will argue that despite the major financial investment, the development of the uses of radioisotopes and their important impact on biology and clinical practices, the assessment of medical uses remained relatively limited. As consequence, the place of biomedicine in the public legitimization of financial investment and civilian uses of nuclear energy began to decline from the late 1950s.

  15. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target.

    Directory of Open Access Journals (Sweden)

    Yongsoon Kim

    Full Text Available In C. elegans, the highly conserved DAF-2/insulin/insulin-like growth factor 1 receptor signaling (IIS pathway regulates longevity, metabolism, reproduction and development. In mammals, acid sphingomyelinase (ASM is an enzyme that hydrolyzes sphingomyelin to produce ceramide. ASM has been implicated in CD95 death receptor signaling under certain stress conditions. However, the involvement of ASM in growth factor receptor signaling under physiological conditions is not known. Here, we report that in vivo ASM functions as a positive regulator of the DAF-2/IIS pathway in C. elegans. We have shown that inactivation of asm-3 extends animal lifespan and promotes dauer arrest, an alternative developmental process. A significant cooperative effect on lifespan is observed between asm-3 deficiency and loss-of-function alleles of the age-1/PI 3-kinase, with the asm-3; age-1 double mutant animals having a mean lifespan 259% greater than that of the wild-type animals. The lifespan extension phenotypes caused by the loss of asm-3 are dependent on the functions of daf-16/FOXO and daf-18/PTEN. We have demonstrated that inactivation of asm-3 causes nuclear translocation of DAF-16::GFP protein, up-regulates endogenous DAF-16 protein levels and activates the downstream targeting genes of DAF-16. Together, our findings reveal a novel role of asm-3 in regulation of lifespan and diapause by modulating IIS pathway. Importantly, we have found that two drugs known to inhibit mammalian ASM activities, desipramine and clomipramine, markedly extend the lifespan of wild-type animals, in a manner similar to that achieved by genetic inactivation of the asm genes. Our studies illustrate a novel strategy of anti-aging by targeting ASM, which may potentially be extended to mammals.

  16. ASM-3 Acid Sphingomyelinase Functions as a Positive Regulator of the DAF-2/AGE-1 Signaling Pathway and Serves as a Novel Anti-Aging Target

    Science.gov (United States)

    Kim, Yongsoon; Sun, Hong

    2012-01-01

    In C. elegans, the highly conserved DAF-2/insulin/insulin-like growth factor 1 receptor signaling (IIS) pathway regulates longevity, metabolism, reproduction and development. In mammals, acid sphingomyelinase (ASM) is an enzyme that hydrolyzes sphingomyelin to produce ceramide. ASM has been implicated in CD95 death receptor signaling under certain stress conditions. However, the involvement of ASM in growth factor receptor signaling under physiological conditions is not known. Here, we report that in vivo ASM functions as a positive regulator of the DAF-2/IIS pathway in C. elegans. We have shown that inactivation of asm-3 extends animal lifespan and promotes dauer arrest, an alternative developmental process. A significant cooperative effect on lifespan is observed between asm-3 deficiency and loss-of-function alleles of the age-1/PI 3-kinase, with the asm-3; age-1 double mutant animals having a mean lifespan 259% greater than that of the wild-type animals. The lifespan extension phenotypes caused by the loss of asm-3 are dependent on the functions of daf-16/FOXO and daf-18/PTEN. We have demonstrated that inactivation of asm-3 causes nuclear translocation of DAF-16::GFP protein, up-regulates endogenous DAF-16 protein levels and activates the downstream targeting genes of DAF-16. Together, our findings reveal a novel role of asm-3 in regulation of lifespan and diapause by modulating IIS pathway. Importantly, we have found that two drugs known to inhibit mammalian ASM activities, desipramine and clomipramine, markedly extend the lifespan of wild-type animals, in a manner similar to that achieved by genetic inactivation of the asm genes. Our studies illustrate a novel strategy of anti-aging by targeting ASM, which may potentially be extended to mammals. PMID:23049887

  17. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target.

    Science.gov (United States)

    Kim, Yongsoon; Sun, Hong

    2012-01-01

    In C. elegans, the highly conserved DAF-2/insulin/insulin-like growth factor 1 receptor signaling (IIS) pathway regulates longevity, metabolism, reproduction and development. In mammals, acid sphingomyelinase (ASM) is an enzyme that hydrolyzes sphingomyelin to produce ceramide. ASM has been implicated in CD95 death receptor signaling under certain stress conditions. However, the involvement of ASM in growth factor receptor signaling under physiological conditions is not known. Here, we report that in vivo ASM functions as a positive regulator of the DAF-2/IIS pathway in C. elegans. We have shown that inactivation of asm-3 extends animal lifespan and promotes dauer arrest, an alternative developmental process. A significant cooperative effect on lifespan is observed between asm-3 deficiency and loss-of-function alleles of the age-1/PI 3-kinase, with the asm-3; age-1 double mutant animals having a mean lifespan 259% greater than that of the wild-type animals. The lifespan extension phenotypes caused by the loss of asm-3 are dependent on the functions of daf-16/FOXO and daf-18/PTEN. We have demonstrated that inactivation of asm-3 causes nuclear translocation of DAF-16::GFP protein, up-regulates endogenous DAF-16 protein levels and activates the downstream targeting genes of DAF-16. Together, our findings reveal a novel role of asm-3 in regulation of lifespan and diapause by modulating IIS pathway. Importantly, we have found that two drugs known to inhibit mammalian ASM activities, desipramine and clomipramine, markedly extend the lifespan of wild-type animals, in a manner similar to that achieved by genetic inactivation of the asm genes. Our studies illustrate a novel strategy of anti-aging by targeting ASM, which may potentially be extended to mammals.

  18. Legalization, Expertise, and Participation: Strategies of Compensatory Legitimation in Educational Policy.

    Science.gov (United States)

    Weiler, Hans N.

    1983-01-01

    Shows how the concept of legitimacy and, in particular, the theoretical construct of compensatory legitimation as a determinant of policy strategies may be useful for the comparative analysis of educational policy in advanced capitalist societies. Uses examples of educational policy in the Federal Republic of Germany and the United States. (BRR)

  19. Central Practitioners' Developing Legitimate Peripheral Participation in a Community of Practice for Changing Schools

    Science.gov (United States)

    Woo, David James

    2015-01-01

    As new technologies continue to shape society, there has been a greater need for communities of practice to facilitate changing teaching and learning practices through technology in schools. Legitimate peripheral participation through these communities of practice has become an essential means to spread and support this technology integration…

  20. Institutional Tendencies of Legitimate Evaluation: A Comparison of Finnish and English Higher Education Evaluations

    Science.gov (United States)

    Vartiainen, Pirkko

    2005-01-01

    This article analyses institutional evaluations of higher education in England and Finland through the concept of legitimacy. The focus of the article is on the institutional tendencies of legitimacy. This author's hypothesis is that evaluation is legitimate when the evaluation process is of a good quality and accepted both morally and in practice…

  1. Kvalitet, faglighed og legitime videnformer i SSP-samarbejdet under transformation

    DEFF Research Database (Denmark)

    Tamborg, Andreas Lindenskov

    2016-01-01

    Quality, professionalism and legitimate knowledge in a changing SSP-collaboration. This article explores the inter professional collaboration in a crime preventive initiative called SSP, which is a collaboration between school, social work and police. By drawing on interviews of actors from...

  2. Health librarians: developing professional competence through a 'legitimate peripheral participation' model.

    Science.gov (United States)

    Clarke, Sara; Thomas, Zoe

    2011-12-01

    This feature considers the legitimate peripheral participation model in developing professional competencies in health librarianship. It is described how this model was used in the development of a framework for mapping and recognising the competencies gained by new health librarians at the Royal Free Hospital Medical Library. HS. © 2011 The authors. Health Information and Libraries Journal © 2011 Health Libraries Group.

  3. "I Don't Want to Hear That!": Legitimating Whiteness through Silence in Schools

    Science.gov (United States)

    Castagno, Angelina E.

    2008-01-01

    In this article, I examine the ways in which silences around race contribute to the maintenance and legitimation of Whiteness. Drawing on ethnographic data from two demographically different schools, I highlight patterns of racially coded language, teacher silence, silencing students' race talk, and the conflating of culture with race, equality…

  4. Stakeholder perspectives on a financial sector legitimation process: the case of NGOs and the Equator Principles

    NARCIS (Netherlands)

    O'Sullivan, N.; O'Dwyer, B.

    2009-01-01

    Purpose - The purpose of this paper is to present an in-depth, context rich, and stakeholder-focused perspective on the legitimation dynamics surrounding the initiation and evolution of one of the key financial sector environmental and social responsibility initiatives in recent years, the Equator

  5. The Evolution of the Quality Agenda in Higher Education: The Politics of Legitimation

    Science.gov (United States)

    Filippakou, Ourania

    2017-01-01

    Taking the evolution of the quality agenda in the UK as its centrepiece, this article analyses the politics of legitimation accompanying the emergence of quality assurance and the contribution of quality enhancement to the power play therein. This article argues that over the last 25 years the quality agenda has been used as a proxy--a state…

  6. Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study

    OpenAIRE

    Garre, Aurora; Martinez-Masana, Gemma; Piquero-Casals, Jaime; Granger, Corinne

    2017-01-01

    Aurora Garre,1 Gemma Martinez-Masana,1 Jaime Piquero-Casals,2 Corinne Granger1 1Innovation and Development, ISDIN S.A., Barcelona, Spain; 2Dermik Clinic, Barcelona, Spain Background: Skin aging is accelerated by multiple extrinsic factors: ultraviolet radiation, smoking and pollution increase oxidative activity, damaging cellular and extracellular components such as DNA, proteins, and lipids. With age, collagen and hyaluronic acid levels decline, resulting in loss of elasticity and moisture ...

  7. Legitimating Multilingual Teacher Identities in the Mainstream Classroom

    Science.gov (United States)

    Higgins, Christina; Ponte, Eva

    2017-01-01

    This article explores the identities of a group of elementary teachers who participated in a professional development (PD) project on multilingual language learners. We study how the participating teachers drew on different aspects of their identities to respond to encouragement to increase their attention to students' diverse multilingual…

  8. Legitimizing the invented Congolese space: The gaze from within in ...

    African Journals Online (AJOL)

    This mechanism of transformation is perceptible in Paul Lomami Tchibamba's novel Ngando (1948), the object of this study. Ngando's imagined colonial city stands out as a site of contrasts and contradictions. However, the duplicated model shows the “transformability” of the new space into “normalcy” by a subversive native

  9. Legitimate Textual Borrowing: Direct Quotation in L2 Student Writing

    Science.gov (United States)

    Petric, Bojana

    2012-01-01

    Using textual analysis and interviews with student writers, this study aims to provide an insight into second language students' use of direct quotations in their MA theses by comparing direct quotations in high-rated and low-rated Master's theses, and by exploring student writers' own motivations to quote directly from sources. The corpus…

  10. of discourse: Online legitimations on the outbreak of Ebola Virus ...

    African Journals Online (AJOL)

    Working within the tenets of Critical Discourse Analysis (CDA) and insights from Stanley Cohen's sociological concept of Moral Panic (MP), this study examined the motivations behind some of the online reactions to the Ebola outbreak in West Africa. News of the outbreak of the dreaded disease in some countries like ...

  11. Rural Communatcation: legitimizing digital inclusion in rural field

    Directory of Open Access Journals (Sweden)

    Juliana Correa Bernardes

    2016-03-01

    Full Text Available Through contemporary analysis, it was noted that the countryside of São Paulo experienced drastic transformation and demanded rural family farmers to adapt themselves to technological innovations, where the most striking is the use of the internet in search of information to the sustainable development of rural property.  The research adopted a methodological way of exploratory, through the case study, which analyzed the general objective the dissemination and usability of information and communication technologies in rural areas in the interior of forms-based applied to farmers in the family farms belonging to theAssociation of banana growers of Tupã. In seeking to achieve this goal, reflected on the use of internet in rural areas and measured-factors that enhance digital communication barriers in rural addressing the digital divide becomes a limiting factor to access. In this sense, the rural communication emerges as relational link mediating solutions and incorporating the diffusion of innovations in the pursuit of digital literacy of farmers contributing to the democratization of society in the information age.

  12. Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.

    Directory of Open Access Journals (Sweden)

    Svenja Illien-Junger

    Full Text Available Diabetes and low back pain are debilitating diseases and modern epidemics. Diabetes and obesity are also highly correlated with intervertebral disc (IVD degeneration and back pain. Advanced-glycation-end-products (AGEs increase reactive-oxygen-species (ROS and inflammation, and are one cause for early development of diabetes mellitus. We hypothesize that diabetes results in accumulation of AGEs in spines and associated spinal pathology via increased catabolism. We present a mouse model showing that: 1 diabetes induces pathological changes to structure and composition of IVDs and vertebrae; 2 diabetes is associated with accumulation of AGEs, TNFα, and increased catabolism spinal structures; and 3 oral-treatments with a combination of anti-inflammatory and anti-AGE drugs mitigate these diabetes-induced degenerative changes to the spine.Three age-matched groups of ROP-Os mice were compared: non-diabetic, diabetic (streptozotocin (STZ-induced, or diabetic mice treated with pentosan-polysulfate (anti-inflammatory and pyridoxamine (AGE-inhibitor. Mice were euthanized and vertebra-IVD segments were analyzed by μCT, histology and Immunohistochemistry.Diabetic mice exhibited several pathological changes including loss in IVD height, decreased vertebral bone mass, decreased glycosaminoglycan content and morphologically altered IVDs with focal deposition of tissues highly expressing TNFα, MMP-13 and ADAMTS-5. Accumulation of larger amounts of methylglyoxal suggested that AGE accumulation was associated with these diabetic degenerative changes. However, treatment prevented or reduced these pathological effects on vertebrae and IVD.This is the first study to demonstrate specific degenerative changes to nucleus pulposus (NP morphology and their association with AGE accumulation in a diabetic mouse model. Furthermore, this is the first study to demonstrate that oral-treatments can inhibit AGE-induced ROS and inflammation in spinal structures and provide a

  13. Tucum-do-Cerrado (Bactris setosa Mart.) May Promote Anti-Aging Effect by Upregulating SIRT1-Nrf2 Pathway and Attenuating Oxidative Stress and Inflammation.

    Science.gov (United States)

    da Cunha, Marcela de Sá Barreto; Arruda, Sandra Fernandes

    2017-11-14

    Aging may be related to oxidative damage accumulation and a low-grade inflammation, both responses are modulated by iron and phytochemicals. This study investigated the effect of tucum-do-cerrado ( Bactris setosa Mart.) consumption on the expression of sirtuins (SIRT 1 and 3) and senescence marker protein-30 (SMP30), and on the redox and inflammatory responses, in adult rats supplemented or not with dietary iron. Male Wistar rats were treated for 12 weeks with: control diet (CT); iron enriched-diet (+Fe); control diet + 15% tucum-do-cerrado (Tuc); or iron enriched-diet + 15% tucum-do-cerrado (Tuc + Fe). Iron supplementation (+Fe) increased liver, spleen and intestine iron levels, transferrin saturation, serum iron, serum TNF-α and IL-6 levels, hepatic carbonyl content and and superoxide dismutase (SOD) activity, hepatic Nrf2 protein and Nqo1 mRNA levels and decreased the renal Sirt1 mRNA levels in relation to CT group. Tucum-do-cerrado consumption (Tuc) increased hepatic SOD activity, Nrf2 and SIRT1 mRNA and protein contents, and Nqo1 mRNA levels, while it decreased the renal SOD activity compared with the CT diet. The consumption of tucum-do-cerrado associated with the iron-enriched diet (Tuc + Fe) increased the iron levels in tissues and serum transferrin saturation, compared to the CT diet, while promoting a decrease in hepatic carbonyl and renal malondialdehyde levels, marginally reducing serum IL-6 levels, and increasing hepatic SIRT1 protein content, renal Sirt1 and hepatic Nrf2 mRNA levels, compared to the +Fe group. None of the treatments altered Smp30 mRNA levels. The results suggest that tucum-do-cerrado consumption might promote an anti-aging effect by increasing SIRT1 expression, which may enhance Nrf2 mRNA and protein levels and its downstream pathway, which in turn decrease oxidative damage to proteins and the levels of inflammatory cytokines (IL-6 and TNF-α), induced by iron excess.

  14. Tucum-do-Cerrado (Bactris setosa Mart. May Promote Anti-Aging Effect by Upregulating SIRT1-Nrf2 Pathway and Attenuating Oxidative Stress and Inflammation

    Directory of Open Access Journals (Sweden)

    Marcela de Sá Barreto da Cunha

    2017-11-01

    Full Text Available Aging may be related to oxidative damage accumulation and a low-grade inflammation, both responses are modulated by iron and phytochemicals. This study investigated the effect of tucum-do-cerrado (Bactris setosa Mart. consumption on the expression of sirtuins (SIRT 1 and 3 and senescence marker protein-30 (SMP30, and on the redox and inflammatory responses, in adult rats supplemented or not with dietary iron. Male Wistar rats were treated for 12 weeks with: control diet (CT; iron enriched-diet (+Fe; control diet + 15% tucum-do-cerrado (Tuc; or iron enriched-diet + 15% tucum-do-cerrado (Tuc + Fe. Iron supplementation (+Fe increased liver, spleen and intestine iron levels, transferrin saturation, serum iron, serum TNF-α and IL-6 levels, hepatic carbonyl content and and superoxide dismutase (SOD activity, hepatic Nrf2 protein and Nqo1 mRNA levels and decreased the renal Sirt1 mRNA levels in relation to CT group. Tucum-do-cerrado consumption (Tuc increased hepatic SOD activity, Nrf2 and SIRT1 mRNA and protein contents, and Nqo1 mRNA levels, while it decreased the renal SOD activity compared with the CT diet. The consumption of tucum-do-cerrado associated with the iron-enriched diet (Tuc + Fe increased the iron levels in tissues and serum transferrin saturation, compared to the CT diet, while promoting a decrease in hepatic carbonyl and renal malondialdehyde levels, marginally reducing serum IL-6 levels, and increasing hepatic SIRT1 protein content, renal Sirt1 and hepatic Nrf2 mRNA levels, compared to the +Fe group. None of the treatments altered Smp30 mRNA levels. The results suggest that tucum-do-cerrado consumption might promote an anti-aging effect by increasing SIRT1 expression, which may enhance Nrf2 mRNA and protein levels and its downstream pathway, which in turn decrease oxidative damage to proteins and the levels of inflammatory cytokines (IL-6 and TNF-α, induced by iron excess.

  15. Communicating the right emotion makes violence seem less wrong : Power-congruent emotions lead outsiders to legitimize violence of powerless and powerful groups in intractable conflict

    NARCIS (Netherlands)

    Kamans, Elanor; van Zomeren, Martijn; Gordijn, Ernestine H.; Postmes, Tom

    In intractable intergroup conflicts, groups often try to frame intergroup violence as legitimate through the use of emotional appeals. Two experiments demonstrate that outsiders' perception of which emotion conflict parties communicate influences the extent to which they legitimize their violence.

  16. ISSUES OF LEGITIMIZING POLITICAL POWER IN THE FIRST HALF OF THE TWENTIETH CENTURY: MAX WEBER AND KARL JASPERS

    Directory of Open Access Journals (Sweden)

    Nicolae IUGA

    2012-12-01

    Full Text Available The issue of legitimizing political power has specific dimensions determined by the historical context. In the period following the First World War, democratic regimes dramatically collapsed due to ample protest movements against the political establishment from different countries, but also as a result of a serious political legitimation crisis, thus making way for the rise of totalitarian regimes of Fascism and Nazism. That time debates on the problem of legitimization political power are symptomatic. Due to the general perception regarding corruption in politics and to the political incapacity to deal with social problems, we can witness a decrease of trust in contemporary democratic regimes.In order to exemplify, in a brief expositive manner, my paper will present the topic of political legitimation approached by Max Weber and Karl Jaspers, in a selection of relevant texts issued by both authors during 1919-1931. The aim of this paper is to highlight the actuality, the validity of Weber’s and Jasper’s statements and also their capacity to give pertinent responses to questions such as: What role do the common values play in the legitimating of power in a democratic society? Are there any kinds of limits regarding the electoral legitimation? How can we make the difference between a legitimate appeal and an illegitimate one, between civism and terrorism?

  17. Legitimizing policies

    DEFF Research Database (Denmark)

    Jørgensen, Martin Bak

    2012-01-01

    , political and economic rights, of moral obligations, of sovereignty, and of equity, as well as of how to define target groups and legal and categorical statuses into the debates. Having a backdrop in the theoretical framework of Carol Bacchi, Anne Schneider and Helen Ingram and Giorgio Agamben, this article...

  18. Consumption and money: legitimate transactions, agreements and interpersonal conflicts in a microcredit program

    Directory of Open Access Journals (Sweden)

    Adrián Koberwein

    2011-12-01

    Full Text Available The objective of this paper is to analyze the production of legitimate transactions in a microcredit policy and to explore the creation of interpersonal agreements and conflicts related to these transactions. Based on an ethnographic approach, the paper focuses on the meanings that actors give to the allocation of money, emphasizing the creation as well as the expression of both ‘economic’ and ‘non-economic’ debts and obligations.

  19. Legitimizing the Educational Experience in the context of the Didactic Methodology

    OpenAIRE

    Marius-Costel ESI

    2010-01-01

    The didactic methodology reminds of the idea of an efficient functioning of the education process. In this way, the systemic perspective of the didactic methodology illustrates the way in which the educational experience transposed at the level of the teaching-learning-evaluating activity. Thus, the didactic courses of action initiated in the context of the educational reality emphasize an image that legitimizes the experience of learning itself in general. Therefore, from a pragmatic perspec...

  20. A Reciprocal Turn in Criminal Justice? Shifting Conceptions of Legitimate Authority

    Directory of Open Access Journals (Sweden)

    Ferry de Jong

    2013-01-01

    Full Text Available The past decade has seen the rise of a fierce, ongoing controversy concerning the authority of criminal courts and the legitimacy of the criminal justice system as such. This article aims to provide some much needed conceptual clarity regarding the primal subjects under discussion: To what do we actually refer when we are using the words 'authority' and 'legitimacy'? What is 'legitimate authority'? For an answer to this question, reference is made to a number of theoretical developments within (political philosophy. The article investigates how developments within the doctrines of the general part of substantive criminal law are related to shifting contemporary views on the general conditions for a legitimate exercise of practical authority. An account of a number of interlocking developments within the doctrinal system of Dutch substantive criminal law serves as a starting point for the subsequent inquiry. It is argued that these developments exemplify shifts in the way authority is distributed over various agents involved in criminal proceedings. It is further argued that these shifts in the distribution of authority parallel notable movements within the philosophical literature on the concept of legitimate authority, that is: a movement from a rationalistic and top-down approach toward a reciprocal, bottom-up approach.

  1. Potential predatory and legitimate biomedical journals: can you tell the difference? A cross-sectional comparison.

    Science.gov (United States)

    Shamseer, Larissa; Moher, David; Maduekwe, Onyi; Turner, Lucy; Barbour, Virginia; Burch, Rebecca; Clark, Jocalyn; Galipeau, James; Roberts, Jason; Shea, Beverley J

    2017-03-16

    The Internet has transformed scholarly publishing, most notably, by the introduction of open access publishing. Recently, there has been a rise of online journals characterized as 'predatory', which actively solicit manuscripts and charge publications fees without providing robust peer review and editorial services. We carried out a cross-sectional comparison of characteristics of potential predatory, legitimate open access, and legitimate subscription-based biomedical journals. On July 10, 2014, scholarly journals from each of the following groups were identified - potential predatory journals (source: Beall's List), presumed legitimate, fully open access journals (source: PubMed Central), and presumed legitimate subscription-based (including hybrid) journals (source: Abridged Index Medicus). MEDLINE journal inclusion criteria were used to screen and identify biomedical journals from within the potential predatory journals group. One hundred journals from each group were randomly selected. Journal characteristics (e.g., website integrity, look and feel, editors and staff, editorial/peer review process, instructions to authors, publication model, copyright and licensing, journal location, and contact) were collected by one assessor and verified by a second. Summary statistics were calculated. Ninety-three predatory journals, 99 open access, and 100 subscription-based journals were analyzed; exclusions were due to website unavailability. Many more predatory journals' homepages contained spelling errors (61/93, 66%) and distorted or potentially unauthorized images (59/93, 63%) compared to open access journals (6/99, 6% and 5/99, 5%, respectively) and subscription-based journals (3/100, 3% and 1/100, 1%, respectively). Thirty-one (33%) predatory journals promoted a bogus impact metric - the Index Copernicus Value - versus three (3%) open access journals and no subscription-based journals. Nearly three quarters (n = 66, 73%) of predatory journals had editors or

  2. Cultural Mediators Seduced by Mad Men::How cultural journalists legitimized a quality TV series in the Nordic Region

    OpenAIRE

    Kristensen, Nete Nørgaard; Hellman, Heikki; Riegert, Kristina

    2017-01-01

    Based on theories about the role of cultural mediators in cultural production and using the TV series Mad Men as a case, this article investigates how cultural journalists in the Nordic countries have contributed to legitimizing “quality TV series” as a worthy field of aesthetic consumption. Key analytical points are as follows: (1) cultural journalists legitimize Mad Men’s quality by addressing aspects internal (aesthetic markers) and aspects external (culture industry markers) to the series...

  3. The Institute of Legitimation of Possession in The New Pará Lands Law N ° 7289/2009

    Directory of Open Access Journals (Sweden)

    Flavio Ricardo Albuquerque Azevedo

    2016-10-01

    Full Text Available This article analyzes the Institute of Legitimation of Possession, as a form of public land acquisition in the State of Pará and investigates the applicable regulations, since the State Law of Para n. 7.289 / 2009 established the legitimacy as a mean of public land alienation, without expressly mentioning the State Decree no. 1054/1996, which declared the forfeiture of the possession of records made before the state land agencies, whose areas were not legitimized.

  4. The Institute of Legitimation of Possession in The New Pará Lands Law N ° 7289/2009

    OpenAIRE

    Azevedo, Flavio Ricardo Albuquerque; da Fonseca, Luciana Costa

    2016-01-01

    This article analyzes the Institute of Legitimation of Possession, as a form of public land acquisition in the State of Pará and investigates the applicable regulations, since the State Law of Para n. 7.289 / 2009 established the legitimacy as a mean of public land alienation, without expressly mentioning the State Decree no. 1054/1996, which declared the forfeiture of the possession of records made before the state land agencies, whose areas were not legitimized.

  5. From Subordination to Hegemony On the Epistemological Legitimation of Mathematics in Natural Philosophy of XVII Century

    Directory of Open Access Journals (Sweden)

    Felipe Ochoa

    2013-12-01

    Full Text Available This article analyzes the epistemological legitimation of mathematics in natural philosophy in the seventeenth century. In the Renaissance it was claimed that mathematics does not meet the Aristotelian criteria of scientificity, and that it did not explain the efficient and final causes. So, its critics, inspired by the Aristotelian tradition, rejected the first attempts to mathematize natural philosophy. The epistemological conditions involved in the debate are examined on the scientific nature of mathematics and its relevance to natural philosophy. A historiographical tour of the mathematization of nature is made to provide new weighing elements with respect to a historically and philosophically more conceptual characterization of the emergence of modern science.

  6. State , Citizenship and Participatory Democracy Between Managerial Reform and Legitimation of Social Power in Public Management

    Directory of Open Access Journals (Sweden)

    Marana Sotero De Sousa

    2016-06-01

    Full Text Available The present article tries to point out the importance of participatory democracy for continuous affirmation of Law Democratic State, shrouded at modifications about citizenship in his evolution between State models following as suffered reforms under Brazilian Public Administration. Through qualitative methodology, especially with historical and hermeneutic procedures and bibliographical sources, the objective is develop the discussion about Popular Participation As legitimation instrument in the decisions that are limited in the administrator space. At the end, show the popular participation and citizens are fundamentals for current democratic model of state.

  7. Counterfeit drug penetration into global legitimate medicine supply chains: a global assessment.

    Science.gov (United States)

    Mackey, Tim K; Liang, Bryan A; York, Peter; Kubic, Thomas

    2015-06-01

    Counterfeit medicines are a global public health risk. We assess counterfeit reports involving the legitimate supply chain using 2009-2011 data from the Pharmaceutical Security Institute Counterfeit Incident System (PSI CIS) database that uses both open and nonpublic data sources. Of the 1,510 identified CIS reports involving counterfeits, 27.6% reported China as the source country of the incident/detection. Further, 51.3% were reported as counterfeit but the specific counterfeit subcategory was not known or verifiable. The most prevalent therapeutic category was anti-infectives (21.1%) with most reports originating from health-related government agencies. Geographically, Asian and Latin American regions and, economically, middle-income markets were most represented. A total of 127 (64.8%) of a total of 196 countries had no legitimate supply chain CIS counterfeit reports. Improvements in surveillance, including detection of security breaches, data collection, analysis, and dissemination are urgently needed to address public health needs to combat the global counterfeit medicines trade. © The American Society of Tropical Medicine and Hygiene.

  8. A tainted trade? Moral ambivalence and legitimation work in the private security industry.

    Science.gov (United States)

    Thumala, Angélica; Goold, Benjamin; Loader, Ian

    2011-06-01

    The private security industry is often represented - and typically represents itself - as an expanding business, confident of its place in the world and sure of its ability to meet a rising demand for security. But closer inspection of the ways in which industry players talk about its past, present and future suggests that this self-promotion is accompanied by unease about the industry's condition and legitimacy. In this paper, we analyse the self-understandings of those who sell security - as revealed in interviews conducted with key industry players and in a range of trade materials - in order to highlight and dissect the constitutive elements of this ambivalence. This analysis begins by describing the reputational problems that are currently thought to beset the industry and the underlying fears about its status and worth that these difficulties disclose. We then examine how security players seek to legitimate the industry using various narratives of professionalization. Four such narratives are identified - regulation, education, association and borrowing - each of which seeks to justify private security and enhance the industry's social worth. What is striking about these legitimation claims is that they tend not to justify the selling of security in market terms. In conclusion we ask why this is the case and argue that market justifications are 'closed-off' by a moral ambivalence that attaches to an industry trading in products which cannot guarantee to deliver the condition that its consumers crave. © London School of Economics and Political Science 2011.

  9. Is Contact with Children Related to Legitimizing Beliefs Toward Sex with Children Among Men with Pedophilia?

    Science.gov (United States)

    Geradt, Max; Jahnke, Sara; Heinz, Julia; Hoyer, Jürgen

    2018-02-01

    Among pedophilic men, social contact with children has been discussed as creating a risk situation for sexual abuse. Also, pedophilic men searching for such contact are seen as harboring more beliefs legitimizing sexual contact with children. However, social contact may also decrease false beliefs. We tested these competing views in an anonymous Internet survey with a non-forensic, non-clinical sample of 104 self-classified pedophilic men. Results showed that both increased social and physical contact were significantly linked to fewer legitimizing beliefs toward sex with children, even when controlling for past psychotherapy, educational level, social desirability, and age. Controlling for previous conviction for child sexual offenses reduced the effect for physical contact, but not for social contact. Exploratory analyses showed that either type of contact had no significant effect on total self-perceived risk of offending. However, pedophilic men with physical contact with children perceived a higher risk of more direct (i.e., child abuse) than indirect offenses (i.e., child pornography offenses) compared to pedophilic men without physical contact. Despite limitations of the correlational design and the only small to moderate effects, the results challenge the assumption that complete avoidance of contact with children is necessary for persons with pedophilia to reduce the risk of abusive behavior.

  10. Discriminating Between Legitimate and Predatory Open Access Journals: Report from the International Federation for Emergency Medicine Research Committee

    Directory of Open Access Journals (Sweden)

    Bhakti Hansoti

    2016-09-01

    Full Text Available Introduction: Open access (OA medical publishing is growing rapidly. While subscription-based publishing does not charge the author, OA does. This opens the door for “predatory” publishers who take authors’ money but provide no substantial peer review or indexing to truly disseminate research findings. Discriminating between predatory and legitimate OA publishers is difficult. Methods: We searched a number of library indexing databases that were available to us through the University of California, Irvine Libraries for journals in the field of emergency medicine (EM. Using criteria from Jeffrey Beall, University of Colorado librarian and an expert on predatory publishing, and the Research Committee of the International Federation for EM, we categorized EM journals as legitimate or likely predatory. Results: We identified 150 journal titles related to EM from all sources, 55 of which met our criteria for OA (37%, the rest subscription based. Of these 55, 25 (45% were likely to be predatory. We present lists of clearly legitimate OA journals, and, conversely, likely predatory ones. We present criteria a researcher can use to discriminate between the two. We present the indexing profiles of legitimate EM OA journals, to inform the researcher about degree of dissemination of research findings by journal. Conclusion: OA journals are proliferating rapidly. About half in EM are legitimate. The rest take substantial money from unsuspecting, usually junior, researchers and provide no value for true dissemination of findings. Researchers should be educated and aware of scam journals.

  11. Do the disadvantaged legitimize the social system? A large-scale test of the status-legitimacy hypothesis.

    Science.gov (United States)

    Brandt, Mark J

    2013-05-01

    System justification theory (SJT) posits that members of low-status groups are more likely to see their social systems as legitimate than members of high-status groups because members of low-status groups experience a sense of dissonance between system motivations and self/group motivations (Jost, Pelham, Sheldon, & Sullivan, 2003). The author examined the status-legitimacy hypothesis using data from 3 representative sets of data from the United States (American National Election Studies and General Social Surveys) and throughout the world (World Values Survey; total N across studies = 151,794). Multilevel models revealed that the average effect across years in the United States and countries throughout the world was most often directly contrary to the status-legitimacy hypothesis or was practically zero. In short, the status-legitimacy effect is not a robust phenomenon. Two theoretically relevant moderator variables (inequality and civil liberties) were also tested, revealing weak evidence, null evidence, or contrary evidence to the dissonance-inspired status-legitimacy hypothesis. In sum, the status-legitimacy effect is not robust and is unlikely to be the result of dissonance. These results are used to discuss future directions for research, the current state of SJT, and the interpretation of theoretically relevant but contrary and null results. PsycINFO Database Record (c) 2013 APA, all rights reserved

  12. Compulsory licensing in Canada and Thailand: comparing regimes to ensure legitimate use of the WTO rules.

    Science.gov (United States)

    Lybecker, Kristina M; Fowler, Elisabeth

    2009-01-01

    This paper examines two recent examples of compulsory licensing legislation: one globally embraced regime and one internationally controversial regime operating under the same WTO rules. In particular, we consider Canadian legislation and the use of compulsory licensing for HIV/AIDS drugs destined for a developing country. This is then contrasted with the conditions under which Thai authorities are pursuing compulsory licenses, the outcomes of their compulsory licenses, as well as the likely impact of the Thai policy. Finally, we construct a rubric to evaluate characteristics of a successful regime. This is used to analyze the Canadian and Thai regimes and frame the expected implications of each national policy. It is hoped that the assessment will guide changes to compulsory licensing design to ensure that legitimate regimes are embraced while illegitimate ones are disallowed.

  13. The legitimating fact in the transcendental deduction of the categories: on Dieter Henrich's reading of Kant

    Directory of Open Access Journals (Sweden)

    Christian Klotz

    Full Text Available This article reconstructs the principal moments of Dieter Henrich's work on Immanuel Kant's theoretical philosophy. Henrich seeks to clarify and regain the fundaments of Kant's theory of knowledge - from which his followers, according to him, have distanced themselves - based on the analysis of the "transcendental deduction of the categories". Firstly, Henrich investigates the proof structure of deduction, comparing the first and the second edition of Critique of Pure Reason. Secondly, he investigates, in the Kantian argument, the relationship between the identity principle of self-consciousness and objectivity. Finally, extending the comparison to Critique of Practical Reason, Henrich elucidates the program and methodology in deduction, showing that the idea of a legitimating fact, borrowed from the juridical notion of a deduction, becomes the fundamental element. We analyse the problems raised by the conception of a philosophical argument based on fundamental "facts".

  14. "An object of vulgar curiosity": legitimizing medical hypnosis in Imperial Germany.

    Science.gov (United States)

    Wolffram, Heather

    2012-01-01

    During the late nineteenth and early twentieth centuries, German medical hypnotists sought to gain a therapeutic and epistemological monopoly over hypnosis. In order to do this, however, these physicians were required to engage in a complex multi-dimensional form of boundary-work, which was intended on the one hand to convince the medical community of the legitimacy and efficacy of hypnosis and on the other to demarcate their use of suggestion from that of stage hypnotists, magnetic healers, and occultists. While the epistemological, professional, and legal boundaries that medical hypnotists erected helped both exclude lay practitioners from this field and sanitize the medical use of hypnosis, the esoteric interests, and sensational public experiments of some of these researchers, which mimicked the theatricality and occult interests of their lay competitors, blurred the distinctions that these professionals were attempting to draw between their "legitimate" medical use of hypnosis and the "illegitimate" lay and occult use of it.

  15. Nationalism and legitimation for authoritarianism: A comparison of Nicholas I and Vladimir Putin

    Directory of Open Access Journals (Sweden)

    Sean Cannady

    2014-01-01

    Full Text Available This article draws parallels between Tsar Nicholas I and current Russian President Vladimir Putin with respect to their use of nationalism to justify statist policies and political authoritarianism. Building upon insights by Alexander Gerschenkron about the economic development of “backwards” states, it argues that both Nicholas and Putin have rhetorically used Western concepts such as nationalism and democracy to legitimize their rule but have modified them to give them more statist content. Under Nicholas, this was exemplified in the tripartite (Orthodoxy, Autocracy, and Nationality Official Nationality policy. Putin has emphasized patriotism, power, and statism to justify centralization of power and authoritarian policies. Putin's policies and rhetoric are strong analogs to those of Nicholas. Ultimately, the goal of this paper is to explain state-inspired Russian nationalism and how it has been aligned with authoritarian politics, as well as specifying similarities between present and past in Russia.

  16. Juridical-Criminal Paternalism, Autonomy and Vulnerability: Legitimation Criteria of Paternalistic Interventions on Individual Autonomy in Criminal Matters

    Directory of Open Access Journals (Sweden)

    Heráclito Mota Barreto Neto

    2015-12-01

    Full Text Available The following paper has as objective questioning the legitimacy of state's paternalistic interventions on individual autonomy by using institutional-criminal instruments. In this path, the paper aims to understand in which cases the State is allowed to interfere in private individual lives under the justification of being promoting a well or avoiding a harm and, as well, in which cases such interference is abusive of individuals self-determination. Into this analysis, the work will study the current concepts of paternalism, the theoretical classifications on paternalistic interventions which will be useful to demonstrate admissible and inadmissible species of paternalism and Joel Feinberg and Gerald Dworkin's anti- paternalistic theories. Following, this subject will be analyzed in association with the implications of juridical-criminal goods involved in conflicts between autonomy, human vulnerabilities and paternalism, specially regarding to the (unavailability of those goods. In the end, the work intends to define legitimation criteria for paternalistic interventions inserted in criminal laws, which superimpose themselves on the individual autonomy, in order to harmonize constitutional values of respect for autonomy, protection of vulnerable individuals and the Criminal Law functions of exclusive protection of juridical goods.

  17. “Greenwashing gas: Might a ‘transition fuel’ label legitimize carbon-intensive natural gas development?”

    International Nuclear Information System (INIS)

    Stephenson, Eleanor; Doukas, Alexander; Shaw, Karena

    2012-01-01

    Natural gas is widely considered to be the crucial “bridging fuel” in the transition to the low-carbon energy systems necessary to mitigate climate change. This paper develops a case study of the shale gas industry in British Columbia (BC), Canada to evaluate this assumption. We find that the transition fuel argument for gas development in BC is unsubstantiated by the best available evidence. Emissions factors for shale gas and LNG remain poorly characterized and contested in the academic literature, and context-specific factors have significant impacts on the lifecycle emissions of shale gas but have not been evaluated. Moreover, while the province has attempted to frame natural gas development within its ambitious climate change policy, this framing misrepresents substantive policy on gas production. The “transition fuel” and “climate solution” labels applied to development by the BC provincial government risk legitimizing carbon-intensive gas development. We argue that policy makers in BC and beyond should abandon the “transition fuel” characterization of natural gas. Instead, decision making about natural gas development should proceed through transparent engagement with the best available evidence to ensure that natural gas lives up to its best potential in supporting a transition to a low-carbon energy system. - Highlights: ► Transition fuel discourse may greenwash gas development. ► Gaps in research obscure emissions factors for LNG and shale gas. ► Climate solution label for shale gas and LNG development in BC is unsubstantiated.

  18. Towards a protocol on fair compensation in cases of legitimate land tenure changes : Input document for a participatory process

    NARCIS (Netherlands)

    Verstappen, Leonardus; Galgani, Pietro; de Adelhart Toorop, Reinier; de Groot Ruiz, Adrian; van Maanen, Eise

    2016-01-01

    The Organising Committee of the Dutch Land Governance Multi-Stakeholder Dialogue has commissioned an investigation into the need and possibility to develop a protocol on fair compensation in cases of legitimate land tenure changes, with a focus on expropriation. This is in line with the Ministry’s

  19. Collective resistance despite complicity : High identifiers rise above the legitimization of disadvantage by the in-group

    NARCIS (Netherlands)

    Jimenez-Moya, Gloria; Rodriguez-Bailon, Rosa; Spears, Russell; de Lemus, Soledad

    How do individuals deal with group disadvantage when their fellow in-group members conceive it as legitimate? Integrating research on the normative conflict model (Packer, 2008, Pers. Soc. Psychol. Rev., 12, 50) and collective action, we expect high identifiers to reject the in-group norm of

  20. 'and to the Herte She Hireselven Smot' : The Loveris Maladye and the Legitimate Suicides of Chaucer's and Gower's Exemplary Lovers

    NARCIS (Netherlands)

    Sobecki, Sebastian

    2004-01-01

    1. III * Middle English: Excluding Chaucer -- Brown et al., 10.1093 ... In '"And to the herte she hireselven smot": The Loveris Maladye and the Legitimate Suicides of Chaucer's and Gower's Exemplary Lovers' (Mediaevalia ... nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; nbsp; 2. Publications of the Medieval

  1. The Three Faces of Power: The U.S. Supreme Court's Legitimization of School Authority's Parental, Police, and Pedagogic Roles.

    Science.gov (United States)

    Ehrensal, Patricia A.

    2003-01-01

    Examines legal and ethical ramifications of three roles of school authorities (agents-of-state, custodial, tutelary) legitimated in two Supreme Court decisions: "New Jersey v. T.L.0." (search and seizure) and "Vernonia v. Action" (drug use testing). (Contains 34 references.)(PKP)

  2. Anti-Ageing Effects of Sonchus oleraceus L. (pūhā Leaf Extracts on H2O2-Induced Cell Senescence

    Directory of Open Access Journals (Sweden)

    Zong-Quan Ou

    2015-03-01

    Full Text Available Antioxidants protect against damage from free radicals and are believed to slow the ageing process. Previously, we have reported the high antioxidant activity of 70% methanolic Sonchus oleraceus L. (Asteraceae leaf extracts. We hypothesize that S. oleraceus extracts protect cells against H2O2-induced senescence by mediating oxidative stress. Premature senescence of young WI-38 cells was induced by application of H2O2. Cells were treated with S. oleraceus extracts before or after H2O2 stress. The senescence- associated β-galactosidase (SA-β-gal activity was used to indicate cell senescence. S. oleraceus extracts showed higher cellular antioxidant activity than chlorogenic acid in WI-38 cells. S. oleraceus extracts suppressed H2O2 stress-induced premature senescence in a concentration-dependent manner. At 5 and 20 mg/mL, S. oleraceus extracts showed better or equivalent effects of reducing stress-induced premature senescence than the corresponding ascorbic acid treatments. These findings indicate the potential of S. oleraceus extracts to be formulated as an anti-ageing agent.

  3. Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex.

    Science.gov (United States)

    Chen, Ci-Di; Zeldich, Ella; Li, Yuexuan; Yuste, Andrea; Abraham, Carmela R

    2018-02-01

    Multiple lines of evidence show that the anti-aging and cognition-enhancing protein Klotho fosters neuronal survival, increases the anti-oxidative stress defense, and promotes remyelination of demyelinated axons. Thus, upregulation of the Klotho gene can potentially alleviate the symptoms and/or prevent the progression of age-associated neurodegenerative diseases such as Alzheimer's disease and demyelinating diseases such as multiple sclerosis. Here we used a CRISPR-dCas9 complex to investigate single-guide RNA (sgRNA) targeting the Klotho promoter region for efficient transcriptional activation of the Klotho gene. We tested the sgRNAs within the - 1 to - 300 bp of the Klotho promoter region and identified two sgRNAs that can effectively enhance Klotho gene transcription. We examined the transcriptional activation of the Klotho gene using three different systems: a Firefly luciferase (FLuc) and NanoLuc luciferase (NLuc) coincidence reporter system, a NLuc knock-in in Klotho 3'-UTR using CRISPR genomic editing, and two human cell lines: neuronal SY5Y cells and kidney HK-2 cells that express Klotho endogenously. The two sgRNAs enhanced Klotho expression at both the gene and protein levels. Our results show the feasibility of gene therapy for targeting Klotho using CRISPR technology. Enhancing Klotho levels has a therapeutic potential for increasing cognition and treating age-associated neurodegenerative, demyelinating and other diseases, such as chronic kidney disease and cancer.

  4. Simultaneous determination of 30 hormones illegally added to anti-ageing functional foods using UPLC-MS/MS coupled with SPE clean-up.

    Science.gov (United States)

    He, Xiaoqin; Xi, Cunxian; Tang, Bobin; Wang, Guomin; Chen, Dongdong; Peng, Tao; Mu, Zhaode

    2014-01-01

    A novel analytical method employing solid-phase extraction (SPE) coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for the simultaneous determination of 30 hormones in anti-ageing functional foods (capsules, powders and tablets). The analytes were extracted with acetic acid-acetonitrile (1-99 v/v), methanol and acetone, respectively. The extract was purified using a combined column, followed by analyte detection with electrospray ionisation in positive- or negative-ion modes. The results indicated that the 30 compounds had good linear correlations in the range of 1-1000 μg kg⁻¹, and the correlation coefficients were above 0.99. The limits of detection (LOD) and limits of quantification (LOQ) were 0.03-2 and 0.1-5 μg kg⁻¹, respectively. The average recovery of 30 compounds at the three spiked levels varied from 74.7% to 124.1%, and the relative standard deviation (RSD) was 2.4-15.0%. This method was applied to the analysis of hormones in 14 real samples of which seven hormones (such as estrone, dienestrol) were detected in four samples, but the remainder of the hormones were not detected. The developed method is sensitive, efficient, reliable and applicable to real samples.

  5. Legitimizing Security in the Ivory Tower: Canadian University Corporate Security Services' Public Quest for Legitimacy.

    Science.gov (United States)

    Wilkinson, Blair

    2016-05-01

    This article examines how university corporate security (UCS) services engage in legitimation work in their attempts to make their university communities (i.e., faculty, staff, students) and political masters (i.e., university administrators, boards of governors, senators) believe that they are honest, trustworthy, and caring and have authority that should be deferred to. This is accomplished through the analysis of interview and observational data collected as part of a research project exploring UCS services at five Canadian universities and an examination of how UCS services at 14 Canadian universities communicate using the social media service Twitter. These UCS services were found to primarily use Twitter for the purposes of soliciting or requesting information and for networking. In communicating through Twitter, UCS services engage in public legitimation work in which they make claims about and attempt to demonstrate their expertise, authority, and accountability. This article argues that both UCS services' particular legitimacy problem (i.e., their possession of both private and public attributes) and the interactive nature of public legitimation work create tensions that may serve to disrupt UCS services' ability to attain legitimacy. Cet article examine la manière dont les services de sécurité d'entreprise à l'université (SEU) s'engagent à légitimer leurs tentatives de persuader leurs communautés universitaires (c'est-à-dire le corps professoral, le personnel et les étudiants) ainsi que la haute administration (c'est-à-dire les administrateurs de l'université, le conseil des gouverneurs et les sénateurs) qu'ils sont honnêtes, attentifs, dignes de confiance, et qu'ils possèdent un niveau d'autorité auquel quiconque devrait se référer. Ceci sera accompli en analysant un corpus d'entrevues et d'observations dans le cadre d'un projet de recherche examinant les services de type SEU dans cinq universités canadiennes, ainsi qu'une étude sur

  6. 40 CFR 260.43 - Legitimate recycling of hazardous secondary materials regulated under § 260.34, § 261.2(a)(2)(ii...

    Science.gov (United States)

    2010-07-01

    ... is discarded material and is a solid waste. In determining if their recycling is legitimate, persons....43 Section 260.43 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) HAZARDOUS WASTE MANAGEMENT SYSTEM: GENERAL Rulemaking Petitions § 260.43 Legitimate recycling of...

  7. From performance to performativity: The legitimization of US security contracting and its consequences.

    Science.gov (United States)

    Krahmann, Elke

    2017-12-01

    Discussions about the legitimacy of private security companies (PSCs) in multilateral military interventions abound. This article looks at how the United States has sought to legitimize the outsourcing of security services to PSCs through performance-based contracting and performance assessments. Both mechanisms aim to demonstrate the effective provision of publicly desirable outcomes. However, the immaterial and socially constructed nature of security presents major problems for performance assessments in terms of observable and measurable outcomes. Performance has therefore given way to performativity - that is, the repetitive enactment of particular forms of behaviour and capabilities that are simply equated with security as an outcome. The implications of this development for the ways in which security has been conceptualized, implemented and experienced within US interventions have been profound. Ironically, the concern with performance has not encouraged PSCs to pay increased attention to their impacts on security environments and civilian populations, but has fostered a preoccupation with activities and measurable capabilities that can be easily assessed by government auditors.

  8. The relation between the substantial law and procedural law in defending subjective rights and legitimate interests

    Directory of Open Access Journals (Sweden)

    Petronela-Adriana Cernat

    2007-12-01

    Full Text Available Taking into account that the Romanian Constitution mentions the "state of law" and "constitutional democracy", concomitantly specifying the essential values- human dignity, citizens' rights and freedoms, the free development of human personality, justice and political pluralism- defended by the domestic legal order, it seems of a real practical interest to notice the concrete means established in order to protect the above mentioned values. As it has been mentioned before, the contentious administrative represents one of the most efficient ways under which the values constitutionally affirmed are guaranteed and defended. The contentious administrative basically answers the old question: "Quis custodiet custodes?", question that comprises one of the most difficult obstacles against the state of law actualization: to find the most efficient procedural ways for the state bodies able to use, directly or indirectly, the coercion force in order to make the citizens observe the laws, to be in their turn under the situation to observe the same laws. As the contentious administrative represents the courts of law activity meant to settle the conflicts whereas at least one of the parties is a public authority, we will try, while evoking procedural aspects, procedural means available for someone prejudiced by a public authority, to stress the weight of the procedural rules in guarantying and defending effectively the citizens' rights and legitimate interests.

  9. Alternative Approaches in Evaluating the EU SME Policy: Answers to the Question of Impact and Legitimization

    Directory of Open Access Journals (Sweden)

    Robert K. GRUENWALD

    2014-08-01

    Findings:  OECD  and  EU  evaluations  do  not  determine  causal  relationships  between funding allocation and effects. The evaluations of the KfW and the German Ministry of Economics  use  an  empirical  quantitative  approach  and  determine  direct  causal relations. In  order to fulfil the requirements of legitimizing functions  for  the  SME  policy,  it  is  recommended  to  further  develop  the  EU  funding policy  and  evaluation  according  to  the  “German  model”  both  in  terms  of  the institutional  framework  and  in  terms  of  the  evaluation  of  impacts  through  funding policy measures. Definition  of  minimum  requirements  and  alternative possibilities  for  EU  SME  policy  evaluation  in  order  to  close  the  legitimisation  gap between the allocation of tax money and impact proof (cost-benefit ratio.

  10. Preparation of transparent fluorocarbon/TiO{sub 2}-SiO{sub 2} composite coating with improved self-cleaning performance and anti-aging property

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Jianping, E-mail: zf161162@163.com; Tan, Zhongyuan; Liu, Zhilei; Jing, Mengmeng; Liu, Wenjie; Fu, Wanli

    2017-02-28

    Graphical abstract: Semicrystalline colloidal particles of TiO{sub 2}-SiO{sub 2} composite oxide were prepared via a sol-gel approach and annealed by a microwave heating treatment. The fabricated fluorocarbon/TiO{sub 2}-SiO{sub 2} composite coatings are transparent, exhibit a highly stable and excellent hydrophilicity, an improved photocatalytic activity and outstanding self-cleaning performance. What’s more, the composite coatings display an excellent anti-aging performance toward UV irradiation. These findings indicate that the fluorocarbon/TiO{sub 2}-SiO{sub 2} composite coatings could be potentially used for outdoor applications. - Highlights: • Semicrystalline colloidal particles of TiO{sub 2}-SiO{sub 2} composite oxide presenting a particle size of 6–10 nm were prepared via a sol-gel approach and annealed by microwave heating method. • The fabricated transparent fluorocarbon/TiO{sub 2}-SiO{sub 2} composite coatings exhibited a superior hydrophilicity, an improved photocatalytic activity and excellent self-cleaning performance. • The fluorocarbon/TiO{sub 2}-SiO{sub 2} composite coatings exhibited an excellent anti-aging performance toward UV irradiation, rendering it quite suitable for outdoor applications. - Abstract: This work reports a facile method to fabricate transparent self-cleaning fluorocarbon coatings filled by semicrystalline colloidal particles of TiO{sub 2}-SiO{sub 2} composite oxide presenting a particle size ranging from 6 to 10 nm. Anatase-TiO{sub 2} crystallites were successfully obtained after microwave heating treatment of the TiO{sub 2}-SiO{sub 2} colloidal particles as confirmed by XRD, TEM and FTIR measurements. The fluorocarbon/TiO{sub 2}-SiO{sub 2} composite coatings exhibited a superior hydrophilicity and an improved photocatalytic activity in contrast to the TiO{sub 2}-filled coatings. In particular, a water contact angle (WCA) value of 4.5° and a decolorization ratio relative to methyl orange as high as 96.0% were

  11. Creating a virtual community of practice to investigate legitimate peripheral participation by African American middle school girls in science activities

    Science.gov (United States)

    Edwards, Leslie D.

    How do teenage girls develop an interest in science? What kinds of opportunities can science teachers present to female students that support their engagement with learning science? I studied one aspect of this issue by focusing on ways students could use science to enhance or gain identities that they (probably) already valued. To do that I created technology-rich activities and experiences for an after school class in science and technology for middle school girls who lived in a low socio-economic urban neighborhood. These activities and experiences were designed to create a virtual community of practice whose members used science in diverse ways. Student interest was made evident in their responses to the activities. Four conclusions emerged. (1) Opportunities to learn about the lives and work of admired African American business women interested students in learning by linking it to their middle-class aspirations and their interest in things that money and status can buy. (2) Opportunities to learn about the lives and work of African American women experts in science in a classroom context where students then practiced similar kinds of actual scientific tasks engaged students in relations of legitimate peripheral participation in a virtual and diverse community of practice focused on science which was created in the after-school classes. (3) Opportunities where students used science to show off for family, friends, and supporters of the after-school program, identities they valued, interested them enough that they engaged in long-term science and technology projects that required lots of revisions. (4) In response to the opportunities presented, new and enhanced identities developed around becoming a better student or becoming some kind of scientist.

  12. Legitimation, Higher Education, and the Post-Colonial State: A Comparative Study of India and Kenya.

    Science.gov (United States)

    Hughes, Rees

    1994-01-01

    Weak states such as India and Kenya may seek to maintain or enhance their legitimacy by expanding access to higher education regardless of manpower needs or scarcity of financial resources. Three common strategies are increasing higher education enrollments, maintaining low fees and high subsidies for postsecondary students, and supporting a…

  13. A system justification view of sexual violence: legitimizing gender inequality and reduced moral outrage are connected to greater rape myth acceptance.

    Science.gov (United States)

    Chapleau, Kristine M; Oswald, Debra L

    2014-01-01

    Rape is a pervasive social problem that causes serious physical and psychological repercussions. Rape victims' recovery is often complicated by the public's failure to believe the victim and restore justice. This study applied system justification theory to examine whether the justification of gender inequality is related to moral outrage (an emotional precursor to corrective action) and rape myth acceptance; we also examined whether rape myth acceptance is associated with moral outrage at injustice. Results showed that gender-specific system justification correlated with less moral outrage at human suffering as well as greater rape myth acceptance. The relationships between these variables were similar for men and for women, a finding that suggests that rape myths are system justifying for women. When we controlled for gender-specific system justification, rape myth acceptance correlated with less moral outrage. Results are discussed in the context of how legitimizing ideologies reduce moral outrage at injustice and perpetuate a system of sexual violence.

  14. The Influence of the Authoritarian Syndrome on the Process of Legitimation of Government Institutions in Today’s Russia

    Directory of Open Access Journals (Sweden)

    Елена Борисовна Григорьева

    2013-12-01

    Full Text Available The article examines the influence of the authoritarian syndrome on the process of legitimization of various bodies and institutions of government, in particular, to establish and maintain a personal type of legitimation. The author offers the analysis of prospects for the transformation of Russian political regime, namely the transfer from the personal type of legitimacy of the political system to the structural type. It shows the dynamics of components of the authoritarian syndrome is widely spread in the mass consciousness of Russians from 1992 to 2012. The article describes a new approach to the authoritarianism, along with cultural, neo-institutional, institutional explanation of the reasons supporting the communication, trust, and an uncritical attitude to the president, stands authoritarian syndrome.

  15. The proliferation of sexual health: Diverse social problems and the legitimation of sexuality.

    Science.gov (United States)

    Epstein, Steven; Mamo, Laura

    2017-09-01

    Especially since the 1990s, the term sexual health has flourished in professional, commercial, and lay domains. Yet the more the phrase has become visible, the greater the mutability in its meanings. These developments matter for an understanding of healthism-the idea that modern individuals are enjoined to recognize a moral obligation to maximize their health. Theorists of healthism have paid relatively little attention to sexuality and its frequent rendering as controversial, illegitimate, or stigmatizing. We argue that because pairing "sexual" with "health" serves to legitimize and sanitize sexuality, the framing of sexual issues as matters of sexual health is widely appealing across multiple social arenas, and this appeal helps to explain both the proliferation of the term and the diversification of its uses. Secondly, we argue that while the polysemy of sexual health might suggest that the phrase lacks a clear meaning, in another sense the term is quite meaningful: content analysis of journal articles, newspaper articles, and websites shows that the semantics of sexual health can be categorized into six social problem niches, within which sexuality and health are construed in distinctive ways. For each social problem framing, we identify the implied meanings of both sexuality and health, the "opposite" of sexual health, the institutional action plans, the individual injunctions, and the presumed ontologies of bodies and selves. By focusing on how the conjoining of "sexual" and "health" changes the meanings of both terms, our analysis adds nuance to discussions of healthism: it challenges a singular conception of healthism and points to the need for clearer consideration of its different forms. At the same time, we call attention to the significance of "sexual healthism" as a particular example of the "will to health" while also highlighting implications of characterizing sexual issues as matters of health. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Voluntary disclosures of intangible assets and legitimization: The production industry of olive oil Divulgación voluntaria de intangibles y legitimación: La industria productora de aceite de oliva Voluntary disclosures of intangible assets and legitimization: The production industry of olive oil

    Directory of Open Access Journals (Sweden)

    Francisca Castilla-Polo

    2012-12-01

    Full Text Available Purpose: The aim of this paper is to analyze whether the decision to disclose intangible assets could be explained by Institutional Theory. Our interest is to provide evidence of his interpretative capacity through an empirical study applied to the olive oil mill industry. Design/methodology/approach: We used a mixed methodological design that combines quantitative and qualitative methods. Findings: In an industry like olive oil mills, not use to providing additional information on intangible assets on a voluntary basis, social legitimization can be seen as a long-term objective because of the lack of urgency associated to it. Instead, a more pragmatic behavior concerned with economic legitimization has been observed, such as those that have been already found. Research limitations/implications: Greater efforts should be made to complete comparative results in a specific industry as well as we consider necessary to analyze longitudinally the evolution of the relationship legitimation-disclosure of intangibles. Originality/value: The results obtained help contribute to the literature coming from Institutional Theory in the sense that the legitimization of a new practice can vary between industries according to the state of the process of its institutionalization in each of them.Objeto: El objetivo de este trabajo es analizar si la decisión de divulgar información sobre intangibles puede ser explicada por la Teoría Institucional. Nuestro interés es proporcionar evidencia de su capacidad interpretativa a través del estudio de la industria productora de aceite de oliva. Diseño/metodología: Empleamos un diseño mixto que combina métodos cuantitativos y cualitativos. Aportaciones y resultados: En una industria como la del aceite de oliva, poco dada a proporcionar información adicional sobre intangibles de manera voluntaria, la legitimación social se considera un objetivo a largo plazo, no así la legitimación económica que sí se asocia al

  17. The legitimation of the power process: experiences of small entrepreneurs in the region of Passo Fundo/RS.

    Directory of Open Access Journals (Sweden)

    Daniel Frasson Lima

    2016-10-01

    Full Text Available The legitimation of power among small entrepreneurs toward the employees was analyzed in the region of Passo Fundo/RS; it’s a process in which these entrepreneurs consolidate working relationships to perform their functions with self-confidence. A descriptive qualitative research was done and used as method of data collection a semi-structured interview, with observation and documental analysis. Four directors of franchises in the field of language education in the northern of Rio Grande do Sul participated in the research. The collected data were submitted to an interpretative analysis that made use of the academic frame to rescue the conception of power, its role and its fountainsin the organizations. The results reinforced the difficulties in measuring the legitimation of power. The phenomenon was investigated from an array of angles and a series of related factors were identified, provokingan evolution on its understanding.It was realized that the strategies of legitimation of the power vary according to the history and leadership style of the directors creating similar results in short term, but not always attending to professionalization and expansion matters.

  18. Legality, legitimacy and formal and informal decision-making processes: when does a decision become legitimate?

    International Nuclear Information System (INIS)

    Zwetkoff, C.

    2004-01-01

    A few words on the purpose of this paper are given by way of introduction. A brief analysis will be made of the relationship between legality and legitimacy in relation to decision-making processes and within the context of the policies concerning the public management of technological risks. The aim is to raise questions and outline some reflections based on the theory of the state, from the perspective of the conditions of the institutionalization of power. I shall first clarify a few conceptual points. The notion of legality refers to the notion of compliance with legal standards, that is to say, with the law. Is the decision made by a person empowered by law so do to (legal competence)? Is it taken in compliance with legal procedure? And are the effects implicitly in keeping with the spirit of the law? The legitimacy of the power of those who govern, or the legitimacy of their decisions, is not determined solely by legal standards but rather, is a matter of individual and social representation or view. As Hobbes says, in essence, to govern is to convince: to convince people of the rightfulness of the source of the power of those who govern and of the action or public policies that they formulate. The paper is organised around three propositions: 1. The role of the legitimacy or social acceptability of public policies has always been an element of the way all political systems function. This role, however, occupies an increasingly important place on the political agenda in a societal decision-making context that has undergone irreversible changes. 2. Although the essence of the social legitimacy of public policies remains the same, the conditions, mechanisms and criteria evolve. 3. The critical centrality of social legitimacy, together with the evolution of the criteria for legitimate decision, today modify the decision-making mechanisms that were established in response to the requirements of classical democracy. We observe a political organisation i n the

  19. Searching for a legitimate television journalism: quality criteria in the critic work of Arthur da Távola in the 1970s

    Directory of Open Access Journals (Sweden)

    Fernanda Mauricio da Silva

    2014-07-01

    Full Text Available In the 1970s, the TV reviews published by Artur da Távola rose a new discursive place for TV journalism: instead of the approach with an impoverishing entertainment, a legitimate discourse through technology. This article discusses how Távola legitimated television journalism through a discourse of quality compared to other media, showing power struggles around the representation of reality, emotional speech and compared with everyday life.

  20. “Top-down” vs. “Bottom-up”: A Dichotomy of Paradigms for the Legitimation of Public Power in the EU

    Directory of Open Access Journals (Sweden)

    Dellavalle Sergio

    2017-11-01

    Full Text Available Public power has been justified by resorting to two different kinds of legitimation: one coming from above, the other emerging from the governed. While legitimation “from above” implies that those who are vested with executive power are qualified in their function because of their allegedly higher competences, “bottom-up” legitimacy always presupposes that only citizens can properly decide on their destiny. After giving a brief account of how both legitimation strategies have developed in the history of political ideas, attention is focused on the theories regarding the legitimacy of public power in the European Union. Indeed, both strands of legitimation of public power are represented here with original proposals, according to the specificity of the supranational condition. But even more interesting is that the research into the characteristics of supranational integration has been one of the most significant fields in which the legitimation “from above” has reappeared in Western thought after a rather long period of marginality, now taking the shape of a technocratic justification. In the main section of the article, the reasons in favour of a democratic “bottom-up” legitimation of the European public power are analyzed first, then those which recur to the so-called “output legitimacy” – in other words to technocratic arguments. The last section of the contribution is dedicated to an overall assessment of the different positions.

  1. REFLECTIONS ON THE ROLE OF WRITING AS A TOOL TO DIAGNOSTIC AND REINTEGRATION OF SUBJECTS WITH COGNITIVE PROBLEMS AND THE NEED OF LINGUISTIC TRAINNING OF PROFESSIONALS IN THE FIELD: TOWARDS A LEGITIMATE INCLUSION

    Directory of Open Access Journals (Sweden)

    Margareth de Souza Freitas Thomopoulos

    2014-12-01

    Full Text Available In this reflection, the role of writing in differential diagnosis of motor aphasias and oral apraxic disorders is discussed, as well as its use as a resource for preserving/rescuing the subjectivity of individuals with other cognitive problems. This study also showed reciprocal influences of orality and writing on cases of children with phonoarticulatory problems. Finally, the formation of elementary teachers and professionals working in the spheres of speech therapy and psycho-pedagogy is problematized in order to promote a legitimate social "inclusion" of subjects with cognitive problems.

  2. The European Court legitimates access of Italian couples to assisted reproductive techniques and to pre-implantation genetic diagnosis.

    Science.gov (United States)

    Turillazzi, Emanuela; Frati, Paola; Busardò, Francesco Paolo; Gulino, Matteo; Fineschi, Vittorio

    2015-07-01

    On 28 August 2012, the European Court of Human Rights (ECHR) issued a judgment regarding the requirements for the legitimate access of couples to assisted reproductive techniques (ART) and to pre-implantation genetic diagnosis (PGD). This judgment concerns the case of an Italian couple who found out after their first child was born with cystic fibrosis that they were healthy carriers of the disease. When the woman became pregnant again in 2010 and underwent fetal screening, it was found that the unborn child also had cystic fibrosis, whereupon she had the pregnancy terminated on medical grounds. In order to have the embryo genetically screened prior to implantation under the procedure of PGD, the couple sought to use in vitro fertilisation to have another child. Since article 1 of the Italian law strictly limits access to ART to sterile/infertile couples or those in which the man has a sexually transmissible disease, the couple appealed to the European court, raising the question of the violation of articles 8 and 14 of the European Convention on Human Rights. The applicants lodged a complaint that they were not allowed legitimate access to ART and to PGD to select an embryo not affected by the disease. The European Court affirmed that the prohibition imposed by Italian law violated article 8 of the European Convention on Human Rights. Focusing on important regulatory and legal differences among EU Nations in providing ART treatments and PGD, we derived some important similarities and differences. © The Author(s) 2014.

  3. Nejnovější účinné látky přírodního původu pro anti-aging kosmetiku

    OpenAIRE

    Fleková, Andrea

    2014-01-01

    Tato diplomová práce studuje problematiku vybraných moderních anti-aging látek v kosmetických prostředcích. V literární rešerši byly popsány základní vlastnosti kůže a faktory ovlivňující její stárnutí. Dále byly popsány základní fyzikální formy kosmetických prostředků, základní kosmetické suroviny a nejnovější trendy v použití anti-aging látek. V experimentální části byly připraveny celkem čtyři fyzikální formy kosmetických prostředků – tonika, séra, masky a krémy. V této práci byly testován...

  4. Information and manipulative techniques as a part of the process of legitimation of political power in Ukraine: an attempt to analyze

    Directory of Open Access Journals (Sweden)

    Havrylyuk Svitlana Ivanivna

    2016-12-01

    Full Text Available The author of the article attempts to analyse the impact of information and manipulative technologies in the process of legitimation of the political power in Ukraine. It is proved that implemented information-manipulative technologies are the key factors of political legitimation and influence the political behaviour of citizens. The article analyses relationship between the applied information and manipulative technologies and perception of political reality of citizens, their political behaviour, electoral results. The necessity of changing the paradigm of legitimacy achieve of political actors in Ukraine is substantiated because of the refusal of politicians, technologists, media (and their owners from destructive legitimation technologies based on the use of information and manipulation technologies. It revealed the importance of a joint search for the subjects of democratic policy instruments of political consolidation of the Ukrainian society.

  5. [Pressure or legitimization? Power and alternatives in the planning and adoption of health reforms in Costa Rica, 1988-1998].

    Science.gov (United States)

    Franzoni, Juliana Martínez

    2006-01-01

    Policies are made in response to the rationale of pressure and legitimization, which join forces in many different ways. This work analyzes the planning and adoption of the health reforms undertaken in Costa Rica between 1988 and 1998. It questions whether political parties, international financial institutions and the technical and bureaucratic elites in each sector can be taken as sufficiently explanatory of themselves. Empirical evidence would suggest that apart from investigating the individual interests of the agents involved, one must also consider the sector reforms that are actually available internationally. The paper draws this discussion into the larger scenario of policy making in Latin America and draws links between this and other stages in policy making and other moments in the construction of the State.

  6. Revealing smuggled nuclear material covered by a legitimate radioisotope shipment using CdTe-based gamma-ray spectrometry

    CERN Document Server

    Lakosi, L; Zsigrai, J; Safar, J

    2003-01-01

    Illicit trade of nuclear materials (NM) represents a serious challenge to radiation monitoring upon scenarios, when legitimate radioisotope shipments are used to obscure the weak radiation of NM. Planar and hemispherical Cd(Zn)Te detectors with a portable mini-multichannel analyzer were proven to be suitable, in measuring times of 10 min order, for revealing the presence of low-enriched or natural U-bearing reactor fuel pellets in amounts of kg order, placed beside transport containers of lead or depleted uranium, which contain high activity sup 6 sup 0 Co (10 GBq range) or sup 1 sup 9 sup 2 Ir (TBq range) radioisotope sources. Such a hand-held or portable device may help authorities combating illicit trafficking of nuclear materials.

  7. Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation.

    Science.gov (United States)

    Taub, Amy; Bucay, Vivian; Keller, Gregory; Williams, Jay; Mehregan, Darius

    2018-04-01

    Anti-aging strategies utilizing stem cells are in the forefront. Alpha and beta defensins are natural immune peptides that have been shown to activate an LGR6-positive stem cell locus in the hair follicle, identified as the source of most new epidermal cells during acute wound healing. We investigated the ability of biomimetic alpha and beta defensin molecules, supplemented with supportive cosmetic ingredients, formulated into three skin care products, at improving the structure and function of aging skin. A participant- and investigator -blinded, placebo-controlled, multi-center trial was performed in outpatient settings. Forty-four healthy female subjects, aged 41-71 years, skin types I-V, completed the study with 2/3 receiving full formula and 1/3 receiving the placebo formula. A skin care regimen of 3 products (serum, cream, and mask) containing alpha-defensin 5 and beta-defensin 3, and other cosmetic ingredients, was applied to the face, post-auricular, and neck skin two times per day for 12 weeks in those receiving full formula, whereas the placebo group received the identically packaged regimen without the active ingredients. Methods of evaluation included histopathology and immunohistochemistry (7 subjects), clinical evaluation of pores, superficial and deep wrinkles based on Griffiths scale, and high-resolution photography (all subjects). In addition, a subset of 15 patients were evaluated with the QuantifiCare system (3-dimensional imaging and skin care scores for evenness, pores, oiliness) and Cortex measurements (high-resolution skin ultrasound, TEWL, elasticity, color, and hydration). Data points for evaluation included baseline, 6 weeks, and 12 weeks. All patients used the same sunscreen and cleanser, which was provided to them. The full formula regimen caused a significantly (P equals 0.027) increased thickness of the epidermis as seen in histology, not seen in the placebo group, with no signs of inflammation. No excessive cell proliferation was

  8. Awareness-Raising, Legitimation or Backlash? Effects of the UN Convention on the Rights of Persons with Disabilities on Education Systems in Germany

    Science.gov (United States)

    Powell, Justin J. W.; Edelstein, Benjamin; Blanck, Jonna M.

    2016-01-01

    Global discourse about human rights, education for all, and inclusive education has altered social norms relating to dis/ability and schooling, especially through awareness-raising, by legitimating advocates' positions and by facilitating policy reforms. Affected by societal and educational change, special education systems and their participants…

  9. "Compensatory Legitimation" in Greek Educational Policy: An Explanation for the Abortive Educational Reforms in Greece in Comparison with Those in France.

    Science.gov (United States)

    Persianis, Panayiotis

    1998-01-01

    Examines the political dynamics of planning and implementing educational reforms in Greece, with comparisons to France. Argues that, as in France, the state's concern for "compensatory legitimation" provides a better tool than those advanced by sociologists or historians for explaining Greece's many failed educational reforms. Compares…

  10. Economic Education within the BME Research Community: Rejoinder to "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory"

    Science.gov (United States)

    Asarta, Carlos J.

    2016-01-01

    Carlos Asarta comments here that Arbaugh, Fornaciari, and Hwang (2016) are to be commended for their work ("Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory" "Journal of Management Education," Dec 2016, see EJ1118407). Asarta says that they make several…

  11. Rediscovering Paideia and the Meaning of a Scholarly Career: Rejoinder to "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory"

    Science.gov (United States)

    Antonacopoulou, Elena P.

    2016-01-01

    In "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory," authors J.B. Arbaugh, Charles J. Fornaciari, and Alvin Hwang ("Journal of Management Education," December 2016 vol. 40 no. 6 p654-691, see EJ1118407) used citation analysis to track the development of…

  12. Progress in the Legitimacy of Business and Management Education Research: Rejoinder to "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory"

    Science.gov (United States)

    Bacon, Donald R.

    2016-01-01

    In this rejoinder to "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory," published in the "Journal of Management Education," Dec 2016 (see EJ1118407), Donald R. Bacon discusses the similarities between Arbaugh et al.'s (2016) findings and the scholarship…

  13. Different actors, different factors: On the discretion in EU multi-level food safety governance to base food safety decisions on science and other legitimate factors

    NARCIS (Netherlands)

    Szajkowska, A.

    2011-01-01

    According to the principle of risk analysis established by Regulation 178/2002, food safety measures in the EU and Member States must be based on scientific risk assessment. Apart from science, however, decision makers should take into account other legitimate factors, such as societal, ethical or

  14. Evaluation of skin firmness by the DynaSKIN, a novel non-contact compression device, and its use in revealing the efficacy of a skincare regimen featuring a novel anti-ageing ingredient, acetyl aspartic acid.

    Science.gov (United States)

    Kearney, E M; Messaraa, C; Grennan, G; Koeller, G; Mavon, A; Merinville, E

    2017-05-01

    One of the key strategies for anti-ageing in the cosmetics industry today is to target the structural changes responsible for ptosis of the skin, given its impact on age perception. Several objective and non-invasive methods are available to characterise the biomechanical properties of the skin, which are operator-dependent, involving skin contact and providing single-dimensional numerical descriptions of skin behaviour. The research introduces the DynaSKIN, a device using non-contact mechanical pressure in combination with fringe projection to quantify and visualise the skin response in 3-dimensions. We examine the age correlation of the measurements, how they compare with the Cutometer ® , and measure skin dynamics following application of a skincare regimen containing established anti-ageing ingredients. DynaSKIN and Cutometer ® measurements were made on the cheek of 80 Caucasian women (18-64 years). DynaSKIN volume, mean depth and maximum depth parameters were correlated with age and 15 Cutometer ® parameters. Subsequently, the firming efficacy of a skincare regimen featuring acetyl aspartic acid (AAA) and a peptide complex was examined in a cohort of 41 volunteers. DynaSKIN volume, mean depth and maximum depth parameters correlate with age and the Cutometer ® parameters that are associated with the skin relaxation phase (R1, R2, R4, R5, R7 and F3). Furthermore, the DynaSKIN captured significant improvements in skin firmness delivered by the skincare regimen. The DynaSKIN is a novel device capable of capturing skin biomechanics at a high level of specificity and successfully detected the firming properties of a skincare regimen. Its independent measuring principle, consumer relevance and skin firmness 3D visualisation capabilities bring objectivity and novelty to product efficacy substantiation evaluation. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Social Stress, Legitimate Violence, and Gun Availability: Links to Weapon-Specific Homicides.

    Science.gov (United States)

    Linsky, Arnold S.; And Others

    In comparative studies of homicide, many theories compete. This study examined two established theories, stress theory and culture of violence theory, in terms of their ability to explain state-to-state differences in the rate of highly specific types of homicides. The separate and joint effects on homicide committed by handguns, shoulder guns,…

  16. Social Evaluations of Stereotypic Images in Video Games: Unfair, Legitimate, or "Just Entertainment"?

    Science.gov (United States)

    Brenick, Alaina; Henning, Alexandra; Killen, Melanie; O'Connor, Alexander; Collins, Michael

    2007-01-01

    The aim of this study is to assess late adolescents' evaluations of and reasoning about gender stereotypes in video games. Female (n = 46) and male (n = 41) students, predominantly European American, with a mean age 19 years, are interviewed about their knowledge of game usage, awareness and evaluation of stereotypes, beliefs about the influences…

  17. The Newest "Reality Show": The Importance of Legitimizing Experimental Learning with Community-Based Research

    Science.gov (United States)

    Johnson, Matthew D.

    2004-01-01

    The study describes how most current biological curricula fail to foster citizenry, how this failure is problematic for conservation, and offers one approach to address the problem. Local city planners and state Department of Fish and Game have proposed a marsh restoration project near the university to compare and contrast how wildlife would…

  18. Disrupt, Coerce, Legitimize, Attract: The Four Dimensions of Russian Smart Power

    Science.gov (United States)

    2017-03-31

    completes the application of Russian Smart Power. The reaction to the downing of Malaysia Airlines flight 17 on 17 July, 2014 by a Russian BUK SA...followed by a sharp decline in academic understanding.3 Investment in government-sponsored institutes for Russian studies should be increased in

  19. A sense of powerlessness fosters system justification: Implications for the legitimation of authority, hierarchy, and government

    NARCIS (Netherlands)

    van der Toorn, J.; Feinberg, M.; Jost, J. T.; Kay, A. C.; Tyler, T. R.; Willer, R.; Wilmuth, C.

    2015-01-01

    In an attempt to explain the stability of hierarchy, we focus on the perspective of the powerless and how a subjective sense of dependence leads them to imbue the system and its authorities with legitimacy. In Study 1, we found in a nationally representative sample of U.S. employees that financial

  20. Dis(en)abled: Legitimating Discriminatory Practice in the Name of Inclusion?

    Science.gov (United States)

    Atkins, Liz

    2016-01-01

    This article explores tensions between the policies and practice of inclusion and the lived experiences of disabled young people in education. Drawing on the narratives of two young men who participated in a small pilot study, it utilises theoretical concepts related to disability, structure and agency, and power and control, as it explores the…

  1. Television News and Presidential Campaigns: The Legitimization of Televised Political Advertising.

    Science.gov (United States)

    Garner, Jane; And Others

    This study investigated the way that network television covered televised political advertising in presidential campaigns from 1972 through 1988. The findings indicated a substantial increase in the coverage of spots on the network evening news in 1988. In addition, 1988 coverage tended to cover negative spots more than positive ones and was more…

  2. Agents of the Father's law in a society of brothers: A philosophic and psychoanalytic perspective on legitimate use of violence.

    Science.gov (United States)

    Even-Tzur, Efrat; Hadar, Uri

    This paper explores subjective processes of "Agents of Law" - individuals who the state grants the authority to use violence - and the dissonance stemming from the contradictory demands posed on them as legitimate users of violence despite the societal taboo against violence. A conceptual model will be offered based on two theoretical legs, Lacanian psychoanalysis and political theories of legitimacy. Specifically, psychoanalytic ideas would serve to examine unconscious processes, subject position and various identifications related to the question of "self-legitimacy" of Agents of Law. A central link between psychoanalysis and political thought is found in the image of the father and in the triad ruler-God-Father, which calls for an oedipal analysis. A psychoanalytic reading of two philosophical schools that elaborated on the question of legitimacy will be presented, and yield two analytic poles of a model for the understanding of possible subject positions of agents of Law: identification with a "Living Father" vs. identification with a "Dead Father". The psychoanalytic reading will shed light on the limitations of the philosophical perspectives in reflecting on the various (im)possible psychological positions of agents of Law. Finally, then, it will be shown how psychoanalysis helps finding words to characterize different nuances in the coping of agents of Law with the contradictory demands posed on them in an age in which God is dead, the father was murdered and the king was beheaded. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. PUBLIC-PRIVATE PARTNERSHIPS AS A LEGITIMATE FORMS OF TRANSFORMATION OF STATE AND COMPANIES COOPERATION

    Directory of Open Access Journals (Sweden)

    Liudmila V. Goryainova

    2014-01-01

    Full Text Available The article outlines the theoretical approaches to the study of the transformation of the forms of interaction between government and firms under the influence of the evolution of the productive forces and relations of production, depending on the mechanism for the coordination of economic activity, the level of competition and the dominant form of ownership. Substantiated, that partnerships between government and firms are a natural result of the transformation of these relations in the post-industrial economy.

  4. Social Evaluations of Stereotypic Images in Video Games: Unfair, Legitimate, or “Just Entertainment”?

    OpenAIRE

    Brenick, Alaina; Henning, Alexandra; Killen, Melanie; O'Connor, Alexander; Collins, Michael

    2007-01-01

    The aim of this study was to assess adolescents' evaluations of, and reasoning about, gender stereotypes in video games. Female (N = 46) and male (N = 41), predominantly European-American, mean age = 19 years, were interviewed about their knowledge of game usage, awareness and evaluation of stereotypes, beliefs about the influences of games on the players, and authority jurisdiction over 3 different types of games: games with negative male stereotypes, and games with negative female stereotyp...

  5. Water shortages raised a legitimate concern over the sustainable development of the drylands of northern China: Evidence from the water stress index.

    Science.gov (United States)

    Li, Jingwei; Liu, Zhifeng; He, Chunyang; Yue, Huanbi; Gou, Siyuan

    2017-07-15

    Developing a greater understanding of water stress dynamics is crucial for sustainable development in global drylands. The primary goal of this study was to examine the water stress dynamics throughout the drylands of northern China (DNC). We first calculated the water stress index (WSI) of all 474 catchments in the DNC in 2003 and 2014. Then, we investigated the water stress dynamics in the DNC between 2003 and 2014 at multiple scales, which included the entire DNC, the drainage basins, and the main cities. In 2014, we found water stress in DNC over an area of 2.05×10 6 km 2 , which accounted for 52.13% of the total area of the DNC. From 2003 to 2014, the water stress in the DNC increased primarily because of increases in the area of irrigated croplands and the population of urban areas, and the total increase in the water stress area reached 3.14×10 5 km 2 , which accounted for 7.98% of the total area of the DNC. We also found that water shortages raised a legitimate concern over the sustainable development of the DNC because the population and urban land area exposed to water stress in the DNC have rapidly increased by 2.61×10 7 persons and 1.25×10 4 km 2 over the past two decades, respectively. Thus, we argue that effective actions are required to address the water stress in the DNC. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Sentiments that Affect Sociopolitical Legitimation of TNCs in Bangladesh, India, and Pakistan

    DEFF Research Database (Denmark)

    Bakhtiar Rana, Mohammad; Sørensen, Olav Jull

    2014-01-01

    and patriotism,’ and ‘ecological balance’, and suggest that tensions stemming from these three sentiments can be managed and often turned into opportunities if appropriate strategies are applied. Eight types of strategies derived from the nine case studies are presented in order to mitigate, manage, and cash...... in on the REN-sentiments in South Asian markets. These strategies include collaboration strategy, local development strategy, strategy of alignment with socio-political actors, local name and staffing strategy, hibernation strategy, sentiment-focused strategy, isomorphism strategy, and openness strategy....

  7. Social science and nuclear waste management: building confidence, legitimizing decisions or increasing comprehension?

    International Nuclear Information System (INIS)

    Litmanen, T.

    2002-01-01

    The societal evaluation of the risks associated with nuclear technology has now continued for over fifty years. Different actors, such as anti-nuclear movements and the nuclear industry, have tried to establish a dominant position in the debate. However, despite the vast amount of research done in technical and natural sciences, debate over the issue continues, and there is not consensus in sight. For the opponents of nuclear technology, the risks are much too high to accept, and for the proponents the risks are controllable and thus at an acceptable level. For a sociologist, it is a challenging task to study this kind of a controversy where each party claims they are absolutely right and that they are the only ones who hold the truth about an issue. What does the disagreement indicate? Why have not the parties found a solution, or a reasonable compromise? Which of them holds the truth? Is there a truth in this issue? By focusing on these kinds of questions, the presentations discuss the role of social science in Finnish nuclear waste management system? It will give a short overview of the way social science was integrated to the process of developing and planning waste management and describe the issues, which have studied in public sector's research programme. It will be argued that in building confidence an important task is to increase overall comprehension of the parties through applied social science research but also through profound theoretical research. (author)

  8. Alternative Approaches in Evaluating the EU SME Policy: Answers to the Question of Impact and Legitimization

    OpenAIRE

    Robert K. GRUENWALD

    2014-01-01

    The objective of the paper is the determination and criticism of existing EU SME Policy evaluation standards and of existing alternatives enabling the discussion of improvements. The  paper  uses  a  comparison  of  different  evaluation methods  applied  by  the  OECD,  the  EU  and  Sweden  and  of  funding  programmes provided by KfW and the German Ministry of Economics; therefore, the paper is an explorative case study. Findings:  OECD  and  EU  evaluations  do  not  determine ...

  9. Social Evaluations of Stereotypic Images in Video Games: Unfair, Legitimate, or "Just Entertainment"?

    Science.gov (United States)

    Brenick, Alaina; Henning, Alexandra; Killen, Melanie; O'Connor, Alexander; Collins, Michael

    2007-06-01

    The aim of this study was to assess adolescents' evaluations of, and reasoning about, gender stereotypes in video games. Female ( N = 46) and male ( N = 41), predominantly European-American, mean age = 19 years, were interviewed about their knowledge of game usage, awareness and evaluation of stereotypes, beliefs about the influences of games on the players, and authority jurisdiction over 3 different types of games: games with negative male stereotypes, and games with negative female stereotypes, and gender-neutral games. Gender differences were found for how participants evaluated these games. Males were more likely than females to find stereotypes acceptable. Results are discussed in terms of social reasoning, video game playing, and gender differences.

  10. Social Evaluations of Stereotypic Images in Video Games: Unfair, Legitimate, or “Just Entertainment”?

    Science.gov (United States)

    Brenick, Alaina; Henning, Alexandra; Killen, Melanie; O'Connor, Alexander; Collins, Michael

    2015-01-01

    The aim of this study was to assess adolescents' evaluations of, and reasoning about, gender stereotypes in video games. Female (N = 46) and male (N = 41), predominantly European-American, mean age = 19 years, were interviewed about their knowledge of game usage, awareness and evaluation of stereotypes, beliefs about the influences of games on the players, and authority jurisdiction over 3 different types of games: games with negative male stereotypes, and games with negative female stereotypes, and gender-neutral games. Gender differences were found for how participants evaluated these games. Males were more likely than females to find stereotypes acceptable. Results are discussed in terms of social reasoning, video game playing, and gender differences. PMID:25722501

  11. Formulation and in Vivo Evaluation for Anti-Aging Effects of an Emulsion Containing Basil Extract Using non- Invasive Biophysical Techniques

    Directory of Open Access Journals (Sweden)

    N. Akhtar

    2011-12-01

    Full Text Available Background and the purpose of study: Skin aging is a complex process induced by constant exposure to ultraviolet (UV irradiation and damages human skin. UV generates reactive oxygen species leading to collagen deficiency and eventually skin wrinkling. Basil contains a number of phenolics and favonoids which possess antioxidant properties. The aim of this study was to formulate and investigate the antiaging potential of a cream containing Basil extract. Methods: A single blinded study was conducted using non-invasive methods. Formulation containing 3% of the concentrated extract of Basil was developed by entrapping in the inner aqueous phase of w/o emulsion and base contained no extract. Both creams were stored at different storage conditions of 8°C, 25°C, 40°C and 40°C+ 75% relative humidity to predict their stabilities. The formulation and base were evaluated for their effects on various skin parameters i.e., moisture and trans epidermal water loss (TEWL, volume, energy and surface evaluation of the living skin (SELS. Results: Significant effects (p≤0.05 were observed for both creams in the case of TEWL. The base showed insignificant (p≤0.05 while formulation showed significant effects on skin moisture. Volume, SELS SEr (skin roughness, SEsc (skin scaliness, SEsm (skin smoothness, SEw (skin wrinkles parameter showed significant decline while texture parameter of ‘Energy' showed significant increase. Conclusion: The results statistically indicated that the active formulation containg extract of Basil exert antiaging effects when applied topically.

  12. Ambient aging of rhenium filaments used in thermal ionization mass spectrometry: Growth of oxo-rhenium crystallites and anti-aging strategies

    Directory of Open Access Journals (Sweden)

    Joseph M. Mannion

    2017-01-01

    Full Text Available Degassing is a common preparation technique for rhenium filaments used for thermal ionization mass spectrometric analysis of actinides, including plutonium. Although optimization studies regarding degassing conditions have been reported, little work has been done to characterize filament aging after degassing. In this study, the effects of filament aging after degassing were explored to determine a “shelf-life” for degassed rhenium filaments, and methods to limit filament aging were investigated. Zone-refined rhenium filaments were degassed by resistance heating under high vacuum before exposure to ambient atmosphere for up to 2 months. After degassing the nucleation and preferential growth of oxo-rhenium crystallites on the surface of polycrystalline rhenium filaments was observed by atomic force microscopy and scanning electron microscopy (SEM. Compositional analysis of the crystallites was conducted using SEM-Raman spectroscopy and SEM energy dispersive X-ray spectroscopy, and grain orientation at the metal surface was investigated by electron back-scatter diffraction mapping. Spectra collected by SEM-Raman suggest crystallites are composed primarily of perrhenic acid. The relative extent of growth and crystallite morphology were found to be grain dependent and affected by the dissolution of carbon into filaments during annealing (often referred to as carbonization or carburization. Crystallites were observed to nucleate in region specific modes and grow over time through transfer of material from the surface. Factors most likely to affect the rates of crystallite growth include rhenium substrate properties such as grain size, orientation, levels of dissolved carbon, and relative abundance of defect sites; as well as environmental factors such as length of exposure to oxygen and relative humidity. Thin (∼180 nm hydrophobic films of poly(vinylbenzyl chloride were found to slow the growth of oxo-rhenium crystallites on the filament

  13. Low grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing achievement.

    Science.gov (United States)

    Candore, G; Caruso, C; Jirillo, E; Magrone, T; Vasto, S

    2010-01-01

    Nowadays, people are living much longer than they used to do, however they are not free from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and individuals, is a post-maturational process that, due to a diminished homeostasis and increased organism frailty, causes a reduction of the response to environmental stimuli and, in general, is associated to an increased predisposition to illness and death. However, the high incidence of death due to infectious, cardiovascular and cancer diseases underlies a common feature in these pathologies that is represented by dysregulation of both instructive and innate immunity. Several studies show that a low-grade systemic inflammation characterizes ageing and that inflammatory markers are significant predictors of mortality in old humans. This pro-inflammatory status of the elderly underlies biological mechanisms responsible for physical function decline and age-related diseases such as Alzheimer's disease and atherosclerosis are initiated or worsened by systemic inflammation. Understanding of the ageing process should have a prominent role in new strategies for extending the health old population. Accordingly, as extensively discussed in the review and in the accompanying related papers, investigating ageing pathophysiology, particularly disentangling age-related low grade inflammation, is likely to provide important clues about how to develop drugs that can slow or delay ageing.

  14. A rapid and sensitive screening system for human type I collagen with the aim of discovering potent anti-aging or anti-fibrotic compounds.

    Science.gov (United States)

    Hashem, Md Abul; Jun, Kyu-Yeon; Lee, Eunyoung; Lim, Soyun; Choo, Hea-Young Park; Kwon, Youngjoo

    2008-12-31

    This study was undertaken with the aim of developing an easy and quick means of analyzing the effect of various compounds on the synthesis and secretion of human type I collagen at the protein level. A modification of the ELISA method was used on HFF-1 cells. For the proof of concept, we used thirteen compounds most of which are known to be antioxidants. Each compound was tested at concentrations of 0, 10 and 100 microM on HFF-1 cells for 24 h. Thirteen sets of experiments for each compound were performed in ANOVA with three replicates. Duncan multiple range test (DMRT) was used to compare the mean values obtained from the treatment groups. From the results it was concluded that Vitamin C, undecylenic acid, conjugated linoleic acid, glycolic acid, and citric acid at 100 microM concentration could be used for anti-wrinkling or protection from premature aging, which requires enhancement of collagen synthesis. Lactic acid, EGCG, resveratrol, and retinol that can inhibit collagen synthesis effectively in a dose-dependent manner may be used for anti-fibrosis treatment purposes.

  15. EU Engagement in the Arctic: Do the Policy Responses from the Arctic States Recognise the EU as a Legitimate Stakeholder?

    Directory of Open Access Journals (Sweden)

    Kamrul Hossain

    2015-11-01

    Full Text Available The Arctic states are bound in an institutional relationship by means of their actions through the Arctic Council (AC—an organisation created by the eight Arctic states. Although a number of its European Union (EU states are both members and observers in the AC, the EU is not, despite its clear stake in the Arctic, for of a number of reasons. The AC twice postponed the application of the EU in 2013; however, it granted the EU the right to observe the AC meetings as an “observer in principle.” In addition to the significant resource and commercial interests of the EU in the Arctic, it assumes a stewardship role in the Arctic. As the leader in combating global climate change, for example, the EU is committed to assuming responsibility for protecting the Arctic environment given that climate change does have a devastating impact in the Arctic. Moreover, the EU is also concerned about its and continental Europe's only indigenous people, the Sámi, a significant proportion of whom live in its Arctic member states of Finland and Sweden. Thus, in recent years, the EU has endorsed a series of policy documents concerning the Arctic. Against the background of this development, this article examines whether the policy responses of the Arctic states with regard to the EU's increased ambition to engage in Arctic matters make it a legitimate actor or stakeholder. The article concludes that even though the Arctic states, as the primary actors, determine the region's governance approach, they see also a general partnership role for the EU with regard to the common goals of knowledge-based responsible governance and sustainable development of the Arctic.

  16. [Anti-aging creams. What really helps?].

    Science.gov (United States)

    Kerscher, M; Buntrock, H

    2011-08-01

    As youth and perception of beauty are considered to be of great importance, an increasing number of new cosmeceuticals have been developed in recent years. This article will describe new, evidence-based ingredients against skin-aging; in particular antioxidants (e.g. vitamin C, niacinamide, different polyphenols and flavonoids) and cell regulators (e.g. retinol, different peptides and growth factors. Important parameters for the quality of cosmetics and cosmeceuticals are evidence-based in-vivo and in-vitro efficacy as well as scientifically approved wanted and unwanted effects.

  17. A Future for the Doctrine of Substantive Legitimate Expectation? The Implications of Kwazulu-Natal Joint Liaison Committee v Mec for Education, Kwazulu Natal

    Directory of Open Access Journals (Sweden)

    Melanie Murcott

    2015-04-01

    Full Text Available In this paper I briefly discuss the development of the doctrine of legitimate expectation in South African law, which had left the way open for the Constitutional Court to develop a doctrine of substantive legitimate expectation in KwaZulu-Natal Joint Liaison Committee v MEC for Education, KwaZulu-Natal (KZN JLC. I then discuss the court's refusal to develop the doctrine in KZN JLC and analyse the approach adopted instead, which saw the court invoke rationality review to create a new legal mechanism for the enforcement of a unilateral, publicly promulgated promise by government to pay on broad public law grounds. I do so from the perspective of whether or not this creative approach amounted to the development of the doctrine by another name. I consider the implications of the creative approach in KZN JLC for the development of the doctrine of substantive legitimate expectation under administrative law in future. Finally I discuss how the creation of a new legal mechanism to enforce publicly promulgated promises to pay was "subversive of PAJA and the scheme in s 33 of the Constitution".

  18. Emperor Ashoka of India: What Makes a Ruler Legitimate? A Unit of Study for Grades 7-12.

    Science.gov (United States)

    Johnson, Jean Elliott; Johnson, Donald James

    During the age of agriculturally based empires, various conquerors from the western Mediterranean to East Asia brought large population areas under their own centralized authority. Gradually many of these conquerors came to realize that, although military might was necessary to gain control over an area, sheer force of arms was not sufficient to…

  19. Dreams of the Hmong Kingdom: The Quest for Legitimation in French Indochina, 1850- 1960, by Mai Na M. Lee. Madison, University of Wisconsin Press, 2015. 430 pages.

    Directory of Open Access Journals (Sweden)

    Nengher N. Vang

    2015-12-01

    Full Text Available This article provides a book review of Mai Na M. Lee’s Dreams of the Hmong Kingdom: The Quest for Legitimation in French Indochina, 1850-1960. Dreams of the Hmong Kingdom. It highlights the contribution of the book to the historiography of the Hmong and provides a critical assessment of the dichotomous analytical framework that Lee uses to analyze the rivalry between Hmong messianic leaders and Hmong political brokers and the competition between the Ly and Lo clans for paramountcy in French Indochina

  20. FRAMING AS LEGITIMATION OF CLIMATE POLICY. CLIMATE CHANGE FRAMES IN ARGENTINIAN AND BRAZILIAN PRESS DURING THE SUMMITS OF DOHA AND WARSAW

    Directory of Open Access Journals (Sweden)

    Luis González Alcaraz

    2014-06-01

    Full Text Available The article aims to describe and compare journalistic frames of climate change produced by two leading newspapers in South America: Clarin of Argentina and Folha de São Paulo of Brazil, in the context of the Doha (COP- 18 and Warsaw (COP -19 conferences. For this, it has used a definition of framing which recognizes its various dimensions: definition of the situation, reasoning about causes, moral evaluations and recommendations or prescriptions. The analysis was addressed by a qualitative process of coding and classification of journalistic texts. The empirical results indicate that the frames produced for the newspapers correspond to the political context to which they belong, that they coincide in pointing to climate change as a serious problem caused primarily by industrialized countries and what must be faced with a sense of urgency, so they tend to legitimate climate policy. In this regard, it is noted that journalistic frames not only guide the interpretation of social problems, but legitimate political action.

  1. Why does Retraction Watch continue to offer support to Jeffrey Beall, and legitimize his post-mortem “predatory” lists?

    Directory of Open Access Journals (Sweden)

    Jaime A. Teixeira da Silva

    2017-07-01

    Full Text Available Retraction Watch is a science watchdog that may give the impression of being both an anti-bad science and an anti-science blog. This blog has tried to legitimize its ethical stance by naming its parent organization The Center for Science Integrity Inc. (CSI, and by appointing a former Chair of the Committee on Publication Ethics (COPE, Elizabeth Wager, to the CSI board of directors. Jeffrey Beall, another science watchdog, often appears in public alongside Adam Marcus and Ivan Oransky, the CSI secretary and president, respectively, and participates in events with Wager. Beall became academically redundant on January 15, 2017. This is because his blog, which hosted a faulty, controversial and misleading list (and thus potentially libelous of “predatory” open access journals and publishers, suddenly went blank. Beall offered no apology or explanation to the public, but was offered intellectual asylum and protection by the University of Colorado, Denver, where he works as a librarian. After a grace period of almost two months, members of the global academic community have now largely lost respect for Beall because of his silence, which may be equated with irresponsibility and/or cowardice. Despite this near extinct academic status, Retraction Watch continues to laud Beall, refer to his now-defunct site and lists as valid, as many as 25 times, and even rely on the Beall blog and lists to support several of their journalistic claims. In the world of science publishing, the legitimization of a “fact” using a defunct or false (i.e., non-factual source, is equivalent to publishing misconduct, and feeds into the “false facts” and “alternative truths” epidemic in journalism that Retraction Watch is now impregnating into science publishing. Why then is Retraction Watch allowed to operate under an ethically superior platform, while expecting scientists and academics to respect basic rules of citing valid references, but while practicing

  2. "Hired Guns" and "Legitimate Voices": The Politics and Participants of Levy Campaigns in Five Ohio School Districts

    Science.gov (United States)

    Ingle, William Kyle; Johnson, Paul Andrew; Petroff, Ruth Ann

    2012-01-01

    Background: In Ohio, levy campaigns are a burdensome task for district administrators and stakeholders alike. To date, there is little research on the districts' role in crafting school budget referenda campaigns. Purpose: This study asked three research questions: How did the macropolitical contexts shape stakeholders' decision making in terms of…

  3. Social Exclusion/Inclusion: Foucault's Analytics of Exclusion, the Political Ecology of Social Inclusion and the Legitimation of Inclusive Education

    Science.gov (United States)

    Peters, Michael A.; Besley, Tina A. C.

    2014-01-01

    This article offers a broad philosophical and historical background to the dyad of social exclusion/inclusion by examining the analytics and politics of exclusion first by reference to Michel Foucault who studies the modern history of exclusion and makes it central to his approach in understanding the development of modern institutions of emerging…

  4. RATIONAL STRUCTURES OF POLITICS IN MONTESQUIEU’S THE SPIRIT OF THE LAWS. PART I: THE KEY ELEMENTS LEGITIMATING THE POWER AND ITS SOURCES

    Directory of Open Access Journals (Sweden)

    MARIUS DUMITRESCU

    2013-05-01

    Full Text Available In The Spirit of the Laws, Montesquieu tried not to discuss about laws, but in fact, about the type of power hiding behind them. Inspired by Plato and Aristotle, he built his own vision on the palingenesis of the political forms and of the principles governing them. Baron de La Brède started from ideas, from spiritual structures, that have the role to create certain social behaviors, and identified three types of government forms, each characterized by its own nature and principle: monarchy, democracy, and despotism. The French philosopher tried to understand, besides the principles ensuring the nature of each government, the key elements legitimating the power and also its sources. The monarchy is seen by Montesquieu as the most suitable regime, for his time, to rule free societies. The aristocracy helps to the maintenance of freedom in royalty by resisting to any attempt of the crown to exceed its constitutional prerogatives. The transition from one form of government to another is done because of the alteration of principles. Democracy is maybe the most exposed to alteration as its excess of freedom leads to the affirmation of the spirit of endless equality that makes everybody wanting to be the equals to the rulers. Montesquieu sees no other solution to replace the degraded forms of political organization than the confederative republic. Such a political organization would answer the need for permanent political flexibility.

  5. From dilemmatic struggle to legitimized indifference: Expatriates’ host country language learning and its impact on the expatriate-HCE relationship

    OpenAIRE

    Zhang, Ling Eleanor; Harzing, Anne-Wil

    2016-01-01

    We address the lack of knowledge concerning the role of host country languages in multinational corporations based on an inductive qualitative study involving 70 interviews with Nordic expatriates and host country employees (HCE) in China.\\ud \\ud Building on the strongly discrepant views of expatriates and HCEs, we demonstrate how expatriates’ willingness to learn and use the host country language lead to different types of expatriate-HCE relationships, ranging from harmonious to distant or s...

  6. Parsimonia cognitiva y legitimación de las injusticias sociales: la creencia en el mundo justo y el fatalismo latinoamericano Cognitive parsimony and legitimization of social injustice: the belief in a just world and latin american fatalism

    Directory of Open Access Journals (Sweden)

    Alicia Barreiro

    2011-12-01

    Full Text Available Este trabajo se ocupa de un tema propio de la psicología social: el conocimiento de sentido común. Particularmente, se analizan las distintas creencias que permiten a las personas pensar y sentir que controlan -o no- el medio en que viven centrándose en la creencia en el mundo justo y el fatalismo latinoamericano. Ambas creencias en su origen psicológico se basan en la necesidad de control del medio y en su contenido cumplen la función de legitimar el orden social y mantener el status quo. Se concluye que la complejidad de este tipo de objetos de estudio implica estudios interdisciplinarios que vinculen diferentes niveles de análisis para así poder dar cuenta de cómo se relacionan los mecanismos psicológicos con los procesos históricos-sociales conformando una visión de la realidad para los distintos grupos sociales.This paper deals with a topic which belongs to social psychology: common sense knowledge. In particular, it analyzes the different beliefs that enable people to think and feel in control -or not- to their environment. This paper makes focus on just world belief and the Latin-American fatalism. Both beliefs are psychological in origin, based on the need for environmental control and their contents serve the function of legitimating social order, supporting the status quo. It is concluded that the complexity of such phenomena involves interdisciplinary studies, which link different levels of analysis in order to explain how psychological mechanisms are related to social historical processes shaping the world views about reality that social groups hold.

  7. "That's What 'College Experience' is": Exploring Cultural Narratives and Descriptive Norms College Students Construct for Legitimizing Alcohol Use.

    Science.gov (United States)

    Russell, Laura D; Arthur, Tabytha

    2016-08-01

    Among the many health issues relevant to college students, overconsumption of alcohol remains a prevalent concern. Circumscribing the drinking habits occurring on campuses are innumerable social norms furthering popular beliefs that alcohol is an inherent part of college life. This case study examines how students encounter, interpret and express the social norms they conceive as constituting their campus culture. Through triangulating ethnographic practices with in-depth interviews, we utilize a narrative lens to explore how students construct meanings and values for alcohol's roles in campus life. Our findings demonstrate how students validate uses of alcohol by coupling its presence with stress, social enhancement, peer responsibility and identity. Moreover, interviewees expressed there being subcultural differences between younger and older students' discourse around alcohol use. We draw from these observations to offer suggestions for engaging students actively in campus interventions that give rise to voices excluded from commonly construed social norms.

  8. Scientific criticism of “Non traditional legitimation for criminal action”: Public Defender`s Office and the custody of rights by means of Criminal Law – one refuse

    Directory of Open Access Journals (Sweden)

    Patrick Cacicedo

    2017-03-01

    Full Text Available In “Non tradicional legitimation for criminal action – legal protection of goods from other public institutions”, Franklyn Roger Alves Silva examines the question of the legitimacy of criminal action in the case of crimes with undetermined taxable person and proposes the recognition of a supplementary legitimization of other Public institutions (such as the Public Defender's Office to promote the criminal action of such crimes when there is inertia of the Public Prosecutor's Office. The analysis carried out in this scientific critique reveals a concern with the direction of the Public Defender in the criminal sphere, which, by showing itself incapable of protecting legal assets through criminal law, can become another agent of the State's punitive power, consequent reproduction of social inequalities and violation of human life and dignity, precisely the reverse of the idea that motivated its constitution as a mechanism for defending the human rights of the vulnerable.

  9. Looking through the Vizão Feita por Xpo a el Rey Dom Affonso Henriques (1659 Franciscans in India and the legitimization of the Braganza monarchy

    Directory of Open Access Journals (Sweden)

    Barreto Xavier, Ângela

    2016-12-01

    Full Text Available Early modern Portuguese political providentialism has attracted significant scholarly interest in recent years. Whether in reference to the legitimization of imperialism in the fifteenth and sixteenth centuries, to the divine justification of royal power in the sixteenth and seventeenth centuries (especially after 1640, to Sebastianism, the Fifth Empire and other forms of millenarism, or to the uses of astrology, scholars have demonstrated that political providentialism was a familiar language to the Portuguese monarchy. Little is known, however, about the formulation and spread of political providentialism in the Asian part of the Portuguese Empire. In this paper I provide a more complex picture of the dissemination of this language in the Estado da Índia through an analysis of the treatise Vizão de Affonso Henriques, written in Goa by Friar António de S. Thiago, in the year 1659. How does this treatise relate to metropolitan political providentialism, namely in the context of the legitimization of the Braganza monarchy? How is Franciscanism crucial in the treatise’s structure? And can the treatise be located at the crossroads of Euro-Asiatic political culture?En los últimos años el estudio del providencialismo político en el Portugal Moderno ha despertado un significativo interés académico. Ya sea como referencia a la legitimación del imperialismo de los siglos XV y XVI, ya a la justificación divina del poder real en los siglos XVI y XVII (sobre todo después de 1640, como al Sebastianismo, al Quinto Imperio y demás formas de milenarismo o a los usos de la astrología, los especialistas han demostrado que el providencialismo era una lenguaje conocido en la monarquía portuguesa. Poco se sabe, sin embargo, de su formulación y propagación en la parte asiática del Imperio portugués. En este trabajo se propone una imagen más compleja de la difusión del providencialismo político en el Estado de la India a través de un an

  10. Coercive Concern or Legitimate Worries?

    DEFF Research Database (Denmark)

    Jordt Jørgensen, Nanna; Bregnbæk, Susanne

    knowledge about an important challenge facing day-care institutions across Europe. Drawing on empirical material from an ongoing ethnographic fieldwork, the paper examines the ways in which children from refugee families in four different daycare institutions are perceived and treated depending......This paper discusses the encounter between refugee families and day-care institutions in Denmark. By taking a dual perspective that explores both the experiences of refugee children and parents on one hand, and the point of view of pedagogues on the other, our research seeks to generate new...

  11. Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts.

    Science.gov (United States)

    Olson, Kristoff A; Beatty, Alexis L; Heidecker, Bettina; Regan, Mathilda C; Brody, Edward N; Foreman, Trudi; Kato, Shintaro; Mehler, Robert E; Singer, Britta S; Hveem, Kristian; Dalen, Havard; Sterling, David G; Lawn, Richard M; Schiller, Nelson B; Williams, Stephen A; Whooley, Mary A; Ganz, Peter

    2015-12-21

    Growth differentiation factor 11 and/or its homologue growth differentiation factor 8 (GDF11/8) reverses age-related cardiac hypertrophy and vascular ageing in mice. We investigated whether GDF11/8 associates with cardiovascular outcomes, left ventricular hypertrophy (LVH), or age in humans. We measured plasma GDF11/8 levels in 928 participants with stable ischaemic heart disease in the Heart and Soul study. We adjudicated heart failure hospitalization, stroke, myocardial infarction, death, and their composite endpoint. Left ventricular hypertrophy was evaluated by echocardiography. We used multivariable Cox proportional hazards models to compare rates of cardiovascular events and death across GDF11/8 quartiles and logistic regression models to evaluate the association between GDF11/8 and LVH. Four hundred and fifty participants (48.5%) experienced a cardiovascular event or death during 8.9 years of follow-up. The adjusted risk of the composite endpoint was lower in the highest compared with the lowest GDF11/8 quartile [hazard ratio (HR), 0.45; 95% confidence interval (CI), 0.33-0.60; P < 0.001]. We replicated this relationship of GDF11/8 to adverse events in 971 participants in the HUNT3 cohort (adjusted HR, 0.34; 95% CI, 0.23-0.51; P < 0.001). Left ventricular hypertrophy was present in 368 participants (39.7%) at baseline. Participants in the highest quartile of GDF11/8 were less likely to have LVH than those in the lowest quartile (adjusted OR, 0.55; 95% CI, 0.35-0.86; P = 0.009). GDF11/8 levels were lower in older individuals (P < 0.001). In patients with stable ischaemic heart disease, higher GDF11/8 levels are associated with lower risk of cardiovascular events and death. Our findings suggest that GDF11/8 has similar cardioprotective properties in humans to those demonstrated in mice. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

  12. Does aging need its own program, or is the program of development quite sufficient for it? Stationary cell cultures as a tool to search for anti-aging factors.

    Science.gov (United States)

    Khokhlov, Alexander N

    2013-02-01

    "Hayflick phenomenon" is used, we can't explain why we age. Nevertheless, many authors virtually put a sign of equality between aging in vitro and aging in vivo, which generates conclusions that are of quite doubtful accuracy. A classic illustration of this is the telomere concept of aging. Originally, the principle of shortening end-segments of DNA (telomeres) during each cell division was formulated at the beginning of seventies by the Russian scientist Aleksey Olovnikov and used by him to explain the limited "proliferative" lifespan in vitro of normal cells. Subsequently, the existence of this phenomenon was confirmed by the results of many research reports, the culmination of which was a publication in which the authors demonstrated the possibility of increasing the proliferative potential of normal cells by introducing the enzyme telomerase to them, thus restoring the lost telomere segments. At the moment it looks like the telomere shortening contributes to aging in vitro only, but not to aging in vivo because an organism never realizes the full proliferative potential of its cells. Besides, the most "responsive to aging" are the organs and tissues consisting of postmitotic cells, for which the concept of proliferative potential loses any meaning in practical terms. We developed another "correlative" model--a model for testing of geroprotectors and geropromoters--the "cell kinetics model." It is based on the well-known correlation between the "age" of cultured cells (age of their donor) and their saturation density. The model allowed us to perform preliminary testing of a lot of different compounds and factors that are interesting from a gerontological point of view, but it revealed no information about the real mechanisms of aging. However, the second model we use in our studies--the "stationary phase aging" model--obviously, is a "gist" model. It is based on the assumption that in the cells of stationary cultures various intracellular changes similar to those of an

  13. Thinking Relationally about Studying "Up"

    Science.gov (United States)

    Stich, Amy E.; Colyar, Julia E.

    2015-01-01

    In this paper, the authors argue that despite a resurgence of elite studies, the majority of existing scholarship works to reify and legitimize social inequality through its language and method. In particular, the authors utilize Pierre Bourdieu's concept of relational thinking to review and critique contemporary research on elite education and…

  14. Emerging Roles of Ganoderma Lucidum in Anti-Aging

    OpenAIRE

    Wang, Jue; Cao, Bin; Zhao, Haiping; Feng, Juan

    2017-01-01

    Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from Ganoderma lucidum, such as Ethanol extract, aqueous extract, mycelia extract, water soluble extract of the culture medium of Ganoderma lucidum mycelia, Ganodermasides A, B, C, D, and some bioactive components of Ganoderma lucidum, including Reishi Polysaccharide Fraction 3, Ganoderma lucidum polysaccharides I, II, II...

  15. A will to youth: the woman's anti-aging elixir.

    Science.gov (United States)

    Smirnova, Michelle Hannah

    2012-10-01

    The logic and cultural myths that buttress the cosmeceutical industry construct the older woman as a victim of old age, part of an "at-risk" population who must monitor, treat and prevent any markers of old age. A content and discourse analysis of 124 advertisements from the US More magazine between 1998 and 2008, revealed three major themes working together to produce this civic duty: (1) the inclusion of scientific and medical authorities in order to define the cosmeceutical as a 'drug' curing a disease, (2) descriptions of the similarities (and differences) between the abilities of cosmeceuticals and cosmetic surgery to restore one's youth, and (3) the logic equating youth with beauty, femininity and power and older age with the absence of these qualities. Together these intersecting logics produce the "will to youth"-the imperative of the aging woman to promote her youthful appearance by any and all available means. Further, by using images and references to fantasies and traditional fairytales, cosmeceutical advertisements both promise and normalize expectations of eternal youth of the aging woman. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Anti-Aging Medicine: Can Consumers Be Better Protected?

    Science.gov (United States)

    Mehlman, Maxwell J.; Binstock, Robert H.; Juengst, Eric T.; Ponsaran, Roselle S.; Whitehouse, Peter J.

    2004-01-01

    The use of interventions claiming to prevent, retard, or reverse aging is proliferating. Some of these interventions can seriously harm older persons and aging baby boomers who consume them. Others that are merely ineffective may divert patients from participating in beneficial regimens and also cause them economic harm. "Free market…

  17. Rejuvenating immunity: ?anti-aging drug today? eight years later

    OpenAIRE

    Blagosklonny, Mikhail V.

    2015-01-01

    The 2014 year ended with celebration: Everolimus, a rapamycin analog, was shown to improve immunity in old humans, heralding ?a turning point? in research and new era in human quest for immortality. Yet, this turning point was predicted a decade ago. But what will cause human death, when aging will be abolished?

  18. How to Create an Anti-Aging Skin Care Plan

    Science.gov (United States)

    ... Registration General information Housing & travel Education Exhibit hall Mobile app 2019 Annual Meeting Derm Exam Prep Course ... SkinPAC State societies Scope of practice Truth in advertising NP/PA laws Action center Public and patients ...

  19. How to Select Anti-Aging Skin Care Products

    Science.gov (United States)

    ... Advocacy priorities AADA Health System Reform Principles Drug pricing and availability CVS dermatologic formulary restrictions Access to ... the best results. Look for a product that targets your concern. There are two reasons for this: ...

  20. Construcción de una Escala Para Medir Creencias Legitimadoras de Violencia en la Población Infantil Elaboration of a Children's Scale That Measures Beliefs Which Legitimize Violence

    Directory of Open Access Journals (Sweden)

    Susan Galdames

    2007-05-01

    Full Text Available Este artículo presenta la construcción y validación preliminar de una escala diseñada para niños y niñas, cuyo objetivo es medir creencias que legitiman la violencia en las relaciones interpersonales. El proceso incluyó su aplicación a 608 niños de 12 colegios de Coquimbo y a 20 niños víctimas de violencia. El instrumento muestra adecuados niveles de confiabilidad y evidencia un constructo multidimensional, compuesto por distintas formas de legitimación de la violencia. Los resultados permiten vincular estas creencias a contextos relaciónales violentos y sugieren su asociación con las variables: cultura escolar y socialización de género. El instrumento se plantea como una herramienta para el estudio de los mecanismos que obstaculizan la erradicación de la violencia en nuestras comunidades.This article presents the development of a scale, designed for children, which measures beliefs that legitimate interpersonal violence. The scale shows adequate reliability and shows evidence of a multidimensional construct, constituted by different ways to legitimize violence. Results suggest an association of this beliefs system with violent relational contexts, school culture and gender socialization. The scale is proposed as a tool for investigation of underlying mechanisms that perpetuate violence in our communities.

  1. Invoking “The Family” to Legitimize Gender- and Sexuality-Based Public Policies in the United States: A Critical Discourse Analysis of the 2012 Democratic and Republican National Party Conventions

    Directory of Open Access Journals (Sweden)

    Andrew Pilecki

    2015-01-01

    Full Text Available Women and sexual minorities in the United States continue to experience subordinate status, and the policy gains they have made in areas such as reproductive rights and marriage equality continue to be challenged in political discourse. We conducted a critical discourse analysis of texts from the 2012 Democratic and Republican national conventions in order to examine the extent to which ideological representations of the family were employed to legitimize public policy positions related to gender (e.g., abortion and sexuality (e.g., same-sex marriage. We analyzed two forms of text (official party platform document, transcripts of speeches with distinct intended audiences (i.e., party members, general audience. Findings revealed that an ideological representation of the traditional family ideal—featuring a heterosexual couple, their children, and asymmetric gender relations—was present within speeches given by both parties, particularly by the spouses of the presidential candidates (Michelle Obama and Ann Romney. Although this ideological representation was subsequently used within the Republican Party platform to legitimize positions against same-sex marriage and abortion, the Democratic Party platform challenged this representation of the family to instead advocate for policy positions in favor of same-sex marriage and women’s reproductive rights. We discuss this ambivalence within Democratic texts in light of the different audiences that party convention texts seek. Implications for gender- and sexuality-based policies are discussed, as well as the importance of examining political discourse across diverse forms and settings.

  2. Construção, usos sociais e busca de legitimidade das tecnologias da geoinformação do INPE | Construction, social uses and legitimation of geioinformational technologies at INPE

    Directory of Open Access Journals (Sweden)

    Paulo Augusto Sobral Escada

    2012-04-01

    Full Text Available Resumo Este artigo analisa a experiência de um grupo de cientistas e especialistas do Instituto Nacional de Pesquisas Espaciais (INPE que buscou consolidar e legitimar, ao longo de duas décadas, um modo próprio de produção de conhecimento científico e tecnológico. Mudanças de paradigma da Política de C&T, nos anos 1990, retiraram o apoio governamental de seus desenvolvimentos, obrigando-os a mudar suas ações estratégicas para que permitisse manter e preservar o modelo endógeno e autônomo de produção do conhecimento. O artigo trabalha com a perspectiva de Pierre Bourdieu (2001, aplicada ao campo científico, e a noção de “translação” de Bruno Latour (2000. A abordagem sociológica contempla e naturaliza os jogos de interesses e disputas no interior do campo científico, bem como destaca o processo de legitimação científica e social do conhecimento. O artigo tem como objetivo principal oferecer uma contribuição aos processos de discussão do modelo das políticas de CTI, principalmente na definição dos conhecimentos a serem produzidos e absorvidos pelo processo de desenvolvimento econômico e social do país. O artigo destaca a necessidade de se ampliar e aprofundar mecanismos democráticos, adotando maior inclusão e transparência nas disputas do campo científico e das políticas de C&T, condições básicas para alcançar um consenso geral que permita emergir um desenvolvimento desejado e planejado por boa parte da sociedade. Palavras-chave Sociologia do Conhecimento, produção de conhecimento, legitimação, democracia e desenvolvimento Abstract This article analyzes the experience of a group of scientists and specialists from the National Institute of Space Research (INPE who aimed to consolidate and legitimize, throughout two decades, its own way of producing scientific and technological knowledge. Changes of paradigm in Science, Technology and Innovation (STI Politics, during the 90s, removed governmental

  3. Reflexões sobre o processo histórico-discursivo do uso da legítima defesa da honra no Brasil e a construção das mulheres Reflections on the historical-discursive process of the use of the legitimate defence of honour in Brazil and the construction of women

    Directory of Open Access Journals (Sweden)

    Margarita Danielle Ramos

    2012-04-01

    Full Text Available O presente artigo busca compreender, à luz da teoria de gênero, como, ainda hoje, nos julgamentos de assassinatos de mulheres a prerrogativa da legítima defesa da honra tem sido usada na defesa do réu como tentativa de reversão da pena de homicídio qualificado. Para tanto, fizemos um estudo dos códigos da legislação vigente no Brasil relacionados ao tema de nosso trabalho desde o período colonial até os dias de hoje. O trabalho procura mostrar como o assassinato das mulheres é o final de uma rede de violações contra elas que tem seu início na forma como as mulheres são produzidas pelo discurso.This work uses a gender perspective to analyse the discourse in six documents in the jurisprudence of Minas Gerais. The objective is to understand how lawyers appeal until the present date to the legitimate defence of honour in trials of men who have killed a woman in order to avoid punishment for their crime. The analysis is based on two sets of studies: the study of the legislation concerning the concept of honour since the colonial period in Brazil and the study of the struggle that the Brazilian feminist movement has undertaken to remove violence against women from the private sphere and turn it into gender violence. The work attempts to show that the murder of women is the final step in a chain of violations against women, which begins in the devalued way that women are produced in discourse.

  4. La legitimación de la realeza entre mayas del Preclásico Tardío. Los mascarones de El Tigre, Campeche Legitimizing royalty among Late Preclassic Maya. The masks from El Tigre-Campeche

    Directory of Open Access Journals (Sweden)

    Ernesto Vargas Pacheco

    2010-01-01

    Full Text Available En el arte monumental del periodo Clásico maya la imagen del señor ocupaba el sitio principal y todas las demás imágenes un lugar secundario. Con este trabajo se quiere demostrar que los soberanos mayas ya en el Preclásico Tardío, o desde antes, usaron la arquitectura para reproducir la topografía del universo y se sirvieron de los mascarones para transmitir la condición divina de sus antepasados, de sus dioses y la suya propia. En El Tigre, Campeche, se han explorado varios mascarones de estuco del Preclásico Tardío, que representan rostros humanos, los cuales bien podrían identificarse como ancestros: antepasados de gobernantes que pretenden divinizarlos para así legitimizar la realeza maya.The images of Maya dignitaries take the most important places in monumental art during Classic period, and all other representations occupy a secondary position in that context. This paper pretends to demonstrate that Maya kings tried to duplicate their conception of the Universe on civic architecture since Preclassic period, or even before; they used huge mask representations to transmit the sacred condition of their ancestors, their gods and their selves. At El Tigre site, in Campeche, have been explored several stucco masks of Late Preclassic date, showing human faces that may represent ancestors of the kings who tried to deify them in order to legitimate Maya royalty.

  5. The participative construction of the criminal decision in democratic states ruled by the law: the guaranty of participation of the parties, through confrontation, in the composition of a fair and legitimate decision

    Directory of Open Access Journals (Sweden)

    Flávio da Silva Andrade

    2017-10-01

    Full Text Available This article concerns a topic that is not new, but it remains current:  the participatory construction of the criminal decision in a democratic State ruled by law. Starting from the concepts of Rule of Law, of Guarantism and of Democracy, it seeks to renew the importance of the equal and dialectical participation of the parties, through the adversarial system, for the composition of a fair and legitimate criminal judicial decision. It is argued, from this perspective, that the parties should take the role of protagonists in the procedural scenario, since the decision should be built in a participatory way, i.e., based on the arguments and evidence presented, thus reducing the gaps that favor judicial discretion and decisionism. It is proposed, therefore, that the solution to the concrete case (acceptance or dismissal of the information or indictment, grant or rejection of a criminal precautionary measure, conviction or acquittal should be elaborated with support on the contribution of the litigants, from the contrast of their arguments and of the evidence produced, in adversarial proceedings, in the regular course of the process.

  6. The construction and legitimation of workplace bullying in the public sector: insight into power dynamics and organisational failures in health and social care.

    Science.gov (United States)

    Hutchinson, Marie; Jackson, Debra

    2015-03-01

    Health-care and public sector institutions are high-risk settings for workplace bullying. Despite growing acknowledgement of the scale and consequence of this pervasive problem, there has been little critical examination of the institutional power dynamics that enable bullying. In the aftermath of large-scale failures in care standards in public sector healthcare institutions, which were characterised by managerial bullying, attention to the nexus between bullying, power and institutional failures is warranted. In this study, employing Foucault's framework of power, we illuminate bullying as a feature of structures of power and knowledge in public sector institutions. Our analysis draws upon the experiences of a large sample (n = 3345) of workers in Australian public sector agencies - the type with which most nurses in the public setting will be familiar. In foregrounding these power dynamics, we provide further insight into how cultures that are antithetical to institutional missions can arise and seek to broaden the debate on the dynamics of care failures within public sector institutions. Understanding the practices of power in public sector institutions, particularly in the context of ongoing reform, has important implications for nursing. © 2014 John Wiley & Sons Ltd.

  7. How much participation makes a participatory process legitimate? Observations from participants in forestry policy-making and nuclear weapons complex management

    International Nuclear Information System (INIS)

    Tuler, S.

    1997-01-01

    Public participation has received increasing attention as a means for improving research, policy-making, and decision-making in a variety of contexts. Regulators have experimented with a variety of participatory approaches to improve the legitimacy of outcomes in the eyes of diverse publics. In this paper the authors will explore how participants (as opposed to planners) perceived legitimacy of both processes and outcomes in planning processes. Data from two case studies will be presented: (1) a forestry planning process in the northeastern US and (2) environmental health, waste management, and clean-up activities in the US nuclear weapons complex. The data reveal that judgments about the appropriateness of particular forms of participation and about the quality of participation can be a critical factor in perceived legitimacy of processes and outcomes, and that judgments of appropriateness and quality are grounded in the experiences of individual participants. In addition, linkages between judgments about the adequacy of participation and legitimacy can be mediated by historical interactions and judgments of trust. Implications for the design of participatory processes will be discussed

  8. Las nuevas tecnologías como instrumento de legitimación de la imagen institucional /The new technologies as a means of legitimizing the corporate image

    Directory of Open Access Journals (Sweden)

    Mercedes Cancelo Sanmartín

    2013-05-01

    ón de acciones de relaciones públicas basadas en la generación de una imagen transparente incide positivamente en la percepción de los ciudadanos sobre el organismo público.AbstractBecause of the importance of the Attorney General in the social structure, it is necessary to study their picture, therefore its legitimacy institucional.El object of this research is the federal program targeted transparency implemented by the institution, whether modified on citizens image created medially.The institutions can not be considered only for its instrumental function, but because they constitute the social nature of man, which is done as an individual to the extent that the community participates in (Sotelo, 2001:23. This is a fundamental pillar of the existence ofcorporate communications. This implies the need for the microcosm of the institutions is in contact with the macrocosm. Also it is not enough that the organization meets its objectives and activities, but also that their task is socially significant. An active recognition, in which society helps build the institution. Due to the legacy that lives on in each institution dumped a set of meanings to society and therefore each new generation that is developed in the same, which explains the identity and fate of societies.The methodology used in the study included surveys of citizens users. To do this we used different methodological tools such as questionnaires with closed questions and / or open. Overall Tamaulipas Mexican citizens regularly make use of its institutions, identified and accepted as part of society smoothly and are informed of the functions they perform and represent utility for users of the same. Also, in the case study, they show a certain image of the Agency, which matches the development and the facts specific to the institution. The results showed that the implementation of public relations based on the generation of a transparent image positively influences the perception of citizens about the

  9. Audiobooks: Legitimate "Reading" Material for Adolescents?

    Science.gov (United States)

    Moore, Jennifer; Cahill, Maria

    2016-01-01

    Several decades of research have established that time spent reading has a positive impact on the cognitive development and academic success of school-aged children and adolescents. Yet, reading among adolescents has been in decline in recent years while engagement with audiobooks has increased. Professionals in librarianship, children's…

  10. A Critical Disability Pedagogy: Legitimizing Dyslexia

    Science.gov (United States)

    Cosenza, Julie

    2017-01-01

    A common understanding is that dyslexia is the inability to spell words, the inability to recall symbols, the inability to recognize sight words, or the inability to decode. Dyslexia is often described in deficiency language--the inability to do something. Deficiency language is a product of special education and continues to dominate common…

  11. Integrative Geragogy: Part 2--Interventions and Legitimizations

    Science.gov (United States)

    Maderer, Peter; Skiba, Alexander

    2006-01-01

    In part 1 of this paper we presented the theory of an integrative geragogy. Integrative geragogy is a basic part of educational gerontology, dealing especially with the oldest of the old, mentally handicapped elderly people, and their potentials. In part 2 the context between theory and practice of an integrative geragogy shall be explained. We…

  12. Governing effective and legitimate smart grid developments

    OpenAIRE

    Langendahl, Per-Anders; Cook, Matthew; Potter, Stephen; Roby, Helen; Collins, Trevor

    2016-01-01

    Smart grids which use Information and Communication Technologies to augment energy network management have been developed in several locations including London and Stockholm. Common rationales for smart grids include: de-carbonising energy supply, maintaining security of supply and promoting affordability. However, beyond these general abstractions, smart grids seem to exhibit considerable diversity in terms of their characteristics and rationales for development. Thus, while the term smart g...

  13. Promoting Inclusive, Accountable, and Legitimate Political ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The 2011 World Development Report, Conflict, Security, and Development, underscored the far-reaching and devastating impact of violent conflict on a country's social fabric, economy, and governance. Some impacts are tangible, including deaths, injuries, displacement, refugee flows, infrastructure destruction, social ...

  14. Epilogue: Cajal's unique and legitimated School

    Directory of Open Access Journals (Sweden)

    Juan eLerma

    2014-07-01

    Full Text Available Santiago Ramón y Cajal is recognized as the founder of modern neuroscience, his discovery’s representing the fundamental pillars of our current understanding of the nervous system. As Cajal's career spanned a critical period in Spanish history, he witnessed strong social demands for progress in culture, education and science. Indeed, the life of Santiago Ramón y Cajal can be considered to reflect the gradual development of Spanish science from the last third of the 19th century. Cajal promoted a national movement that had important consequences for Spanish science, mainly triggered by the creation of the Junta para Ampliación de Estudios e Investigaciones Científicas, an instrument he established to enrich scientific research and that was later to bear such abundant fruit. The school generated by Cajal profited from this development, through which all Cajal’s disciples received fellowships to train in laboratories across Europe. Unfortunately, the Spanish Civil War disrupted this revitalization of Spanish science and provoked the diaspora of many Spanish scientists. However, a political impulse, mostly following this spirit, was resumed in Spain during the eighties that successfully led to a renaissance in Spanish science.

  15. Promoting Inclusive, Accountable, and Legitimate Political ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Public confidence in state security forces must be rebuilt to ensure success. This project will analyze the post-2007 electoral violence in Kenya and highlight how formal and informal security institutions' role, performance, and reforms were essential to avoiding a relapse into violence. Researchers will examine the lessons ...

  16. Plyometrics: A Legitimate Form of Power Training?

    Science.gov (United States)

    Duda, Marty

    1988-01-01

    Plyometric exercises or drills combine speed and strength to produce an explosive-reactive movement or increased power. Some world-class athletes have used plyometric-training in sports such as high-jumping, hurdles, football, baseball, and hockey. The method is still considered experimental. Sample exercises are described. (JL)

  17. Predikante opleiding: Roeping, keuring en legitimering

    Directory of Open Access Journals (Sweden)

    M. Nel

    2002-08-01

    Full Text Available Training of Pastors: Calling, Testing and Ordination The profession of being a pastor is under pressure. The challenge for churches and seminaries is to rediscover what it means to be called, and more specifically to be called for full time ministry in a local church. Such a calling needs to be secularised in order to be recovered. In this process the �job� of the called one needs to be determined, at least to a larger extent, by the congregation or parish. The point in question here is the fact that such �functions� as pastors are being given by God for equipping the body (Eph 4:7-16. When this is a reality, testing for such a call asks for a commitment to what the call, training for the profession and retaining status imply. Such testing leads to new freedom and the discovery of the complex nature of ministry on the one hand, and giftedness for specific ministries on the other. While further research is needed, the intermediate questions are whether there are seminaries that are willing to partner with churches to find an answer to the growing gap between professional training and church-based-training, and whether there are churches with the courage to take recruitment, testing, and ongoing training more serious.

  18. Pregorexia: A Legitimate Problem during Pregnancy?

    Science.gov (United States)

    ... pregnancy, some women do excessively worry about their weight gain and experience body image issues during pregnancy. The risk of pregorexia ... provider can help you determine an appropriate weight gain during ... your pre-pregnancy weight and body mass index. He or she can also explain ...

  19. BİRİNCİ DÜNYA SAVAŞI’NDA OSMANLI-ALMAN İTTİFAKINI MEŞRULAŞTIRMA ÇABALARI / OTTOMAN EFFORTS TO LEGITIMIZE GERMAN ALLIANCE WITH IN WORLD WAR I

    Directory of Open Access Journals (Sweden)

    Mehmet Ali KARAMAN

    2014-11-01

    Full Text Available Bu çalışma Osmanlı Devleti’nin Almanya ile ittifak yaparak Birinci Dünya Savaşı’na dahil olması üzerine yoğun tenkitlere maruz kalan Osmanlı hükûmetinin attığı adımı meşrulaştırmak amacıyla askeri basın ve yayın organlarında başlattığı propaganda çalışmalarını ayrıntılı olarak belgeleriyle incelemektedir. İngiltere ve Rusya’nın 19. yüzyılın sonlarına doğru Osmanlı karşıtı siyaset izlemeleri nedeniyle Osmanlı askeri yayınları Almanya ile ittifakı bir ehven-i şer olarak görmüş ve bu yüzden başında Almanya ile birlikte savaşa girmenin kaçınılmaz olduğu vurgulanmıştır. This article examines the Ottoman government propaganda in the Ottoman military publications to legitimize the Ottoman Empire’s entrance in World War I on the side of Germany after the government faced harsh criticism for its decision to side with Germany. Because the other major powers, G. Britain and Russia adopted an explicitly anti-Ottoman foreign policy in the late nineteenth century, the Ottoman military publications presented the alliance with Germany as the least bad option and stated it as an inevitable outcome.

  20. From Journalism Studies to Journalism Theory

    Directory of Open Access Journals (Sweden)

    Elias Machado

    2005-06-01

    Full Text Available This paper comprises three parts –- 1 recognition of professional practice as a legitimate object of research; 2 development of methodologies that are adjusted to the particularities of the area; and 3 funding of multidisciplinary experiments on applied research. My intention here is to build on the mapping of existing studies to discuss some assumptions and to consolidate journalism as a fi eld of knowledge, based on the distinction between journalism studies and journalism theories.

  1. A Study on the Impact of Teacher Attitude/Efficacy on the Use of Classroom Technology

    Science.gov (United States)

    Ott, Jeran Louis

    2017-01-01

    Increased access to technology has changed the current educational landscape and, will dramatically affect the future of education. These shifts are redefining the roles of educators and require that teachers have the attributes necessary to legitimately incorporate technology into the classroom. The purpose of this study is to examine existing…

  2. Ethnic Studies and Audiovisual Media: A Listing and Discussion. An Occasional Paper from ERIC at Stanford.

    Science.gov (United States)

    Layer, Harold A.

    Ethnic studies curricula may legitimately explore not only the historical, sociological, and cultural background of mixed ethnic groups, but may also examine alternative means of eliminating inequities and injustices--means by which the powerless can obtain power. This media list offers titles and sources of 16mm films, audiotapes, filmstrips,…

  3. An Empirical Approach to Salary Discrimination: With Case Study of Sex Discrimination in Education

    Science.gov (United States)

    Anderson, Julie A.; Murphy, Norman C.

    1977-01-01

    A statistical method to determine sex discrimination in salaries considered known differential variables which can legitimately be used to determine salary level apart from discrimination based on improper criteria, such as race, sex, religion, etc. This case study of a group of educators exemplifies salary discrimination based on sex. (Author/MV)

  4. The Hermeneutical Approach in Translation Studies

    Directory of Open Access Journals (Sweden)

    Bernd Stefanink

    2017-09-01

    Full Text Available Our aim is to convince the reader of the validity of the hermeneutical approach in translation studies. In a first part, we will show that this validity is based on the fact that the hermeneutical approach integrates factors like subjectivity, intuition, corporeality and creativity in its theoretical reflection, being thus close to the reality of the translation process. In a second part, we will situate this approach in the context of the development of modern translation studies since the 1950s, and show that this development was characterized by a dominating tendency that led from an atomistic to a more and more holistic view of the translation unit, legitimating the holistic approach, which is fundamental in translational hermeneutics. Our third part relates the history of philosophical hermeneutics as the legitimate foundation of translational hermeneutics. In a fourth part, devoted to the “outcoming perspectives”, we will try to reinforce the legitimacy of the hermeneutical approach by showing how it is supported by recent results of research in cognitive science. In order to foster further research in translational hermeneutics we also offer a methodology based on hermeneutic principles to study the translation process. Finally, we give an example of legitimation of a creative problemsolving based on a hermeneutical approach of a translation problem which finds its validation in the results of cognitive research.

  5. How Effective Are Working Memory Training Interventions at Improving Maths in Schools: A Study into the Efficacy of Working Memory Training in Children Aged 9 and 10 in a Junior School?

    Science.gov (United States)

    Cunningham, James; Sood, Krishan

    2018-01-01

    This study evaluates the validity of claims that Working Memory (WM) training is an effective and legitimate school-based maths intervention. By analysing the current developments in WM in the fields of neurology and cognitive psychology, this study seeks to analyse their relevance to the classroom. This study analyses memory profiles of children…

  6. Understanding National Trajectories of Regionalism Through Legitimate, Political and Administrative Capital:A Comparative Case Study of the Institutional Degrees of Regionalism and the Actors’ Abilities to Create Institutional Elements, Collaborate and Coordinate Policies in England, Poland And Denmark

    OpenAIRE

    Larsen, Peter Wilgaard; Ferry, Martin

    2015-01-01

    Regionalism is an ism referring to “political movements which demand greater control over the affairs of theregional territory by the people residing in that territory” (Keating, 1997:5). Despite the successful influence ofthis ideology on decision-makers from the European Commission to the national and regional levels (Salone,2010: 1213), not many attempts have been made in understanding the trajectories of Regionalism. In otherwords, what drives national, regional and local actors’ ability ...

  7. Going to the doctor with enhancement in mind – An ethnographic study of university students’ use of prescription stimulants and their moral ambivalence

    DEFF Research Database (Denmark)

    Petersen, Margit Anne; Nørgaard, Lotte Stig; Traulsen, Janine Marie

    2015-01-01

    these students use doctors as easy access to study drugs, and legitimize their use of stimulants because they were prescribed. The second theme, “A good cause”, shows that the purpose is what counts as a measure for whether stimulant use is considered morally acceptable or not. The third theme, “Being...

  8. Reading behaviour from adolescence to early adulthood: A panel study of the impact of family and education on reading fiction books

    NARCIS (Netherlands)

    Nagel, I.; Verboord, M.

    2012-01-01

    In this article we study how the frequency of book-reading - a form of legitimate culture - develops in the period from adolescence to young adulthood and how it is influenced by parents' education, parental reading socialization climate, school and their interactions. In disentangling parental and

  9. A legitimação moral dos direitos humanos: uma análise dos princípios de justiça de John Rawls / The moral legitimation of human rights: an analysis on John Rawls’ principles of justice

    Directory of Open Access Journals (Sweden)

    Ana Paula Barbosa-Fohrmann

    2011-12-01

    Full Text Available Resumo Este artigo analisará, em primeiro lugar, o significado kantiano de legitimação e a sua distinção em relação à legitimidade. Num segundo momento, tratará de aspectos centrais da teoria de John Rawls, o qual influenciado por Kant, Locke e Rousseau, construiu uma teoria universalista e procedimental baseada em princípios morais de justiça. Por fim, serão ainda apresentadas algumas críticas à teoria rawlsiana. Palavras-chave: legitimação; teoria da justiça; elementos estruturadores; princípios morais de justiça; críticas à teoria rawlsiana. Abstract This paper will examine, first, the Kantian notion of legitimation, and the distinction between legitimation and legitimacy. Secondly, it will address some key aspects of John Rawls’ theory, who influenced by Kant, Locke and Rousseau, built a universal and proceduralist theory grounded on the moral principles of justice. Finally, some critics on Rawlsian theory will be also presented. Keywords: legitimacy; a theory of justice; structuring elements; the moral principles of justice; critics on Rawlsian theory.  

  10. „Denn du gehst gleich ein in ewige Gärten.“ Zum Zusammenhang zwischen transzendenter Weltanschauung und Gewaltbegründung (“You Will Enter Eternal Gardens.“ On the Connection Between Transcendental Worldviews and Legitimizing Violence

    Directory of Open Access Journals (Sweden)

    Lucia Heisterkamp

    2017-12-01

    Full Text Available Discussions about Islamist violence can often be divided into two different trends: one that claims Islam to be essentialy violent per se and another one arguing that violence has nothing to do with Islam. Latter line of argument, particularly in academic discourses, frequently suggests that assailants use religion merely as an instrument to achieve their actually economic-rational interests. However, such argumentation tends to neglect an essential dimension of the whole phenomenon of religiously motivated violence: the spiritual or transcendental worldview which perpetrators use to legitimate their own violence. This article looks into the connection between a religiously based ideology and the representation of violence. To do so, six different documents will be analyzed: the “spiritual guidance“ of the perpetrators involved in the 9/11 attacks (Seidensticker, 2004, four contemporary texts of jihadist actors (mainly from jihadist internet platforms; Lohlker, 2009 and the charter of the terror organization Hamas. Based on these texts, it will be shown how the authors legitimize violence in regard to four fundamental metaphysical principles: the existence of god, the belief in an afterlife, the dichotomous separation of humanity into good and evil and the relevance of a spiritual mindset. The results of the analysis suggest that there is an interior logic of religiously motivated violence, based on premises differentiated from the liberal secularization paradigm and instead following a transcendent understanding of reality. Recognizing this paradigm as one important dimension of Islamist violence could help to better understand such phenomenon and to improve practical work in the field of deradicalization. Article in German

  11. In vitro determination of the anti-aging potential of four southern African medicinal plants

    CSIR Research Space (South Africa)

    Ndlovu, G

    2013-11-01

    Full Text Available Aging is an inevitable process for all living organisms. During this process reactive oxygen species generation is increased which leads to the activation of hyaluronidase, collagenase and elastase, which can further contribute to skin aging. Four...

  12. One size may not fit all: anti-aging therapies and sarcopenia.

    Science.gov (United States)

    Burks, Tyesha N; Cohn, Ronald D

    2011-12-01

    Sarcopenia refers to age-related loss of muscle mass and function. Several age-related changes occur in skeletal muscle including a decrease in myofiber size and number and a diminished ability of satellite cells to activate and proliferate upon injury leading to impaired muscle remodeling. Although the molecular mechanisms underlying sarcopenia are unknown, it is tempting to hypothesize that interplay between biological and environmental factors cooperate in a positive feedback cycle contributing to the progression of sarcopenia. Indeed many essential biological mechanisms such as apoptosis and autophagy and critical signaling pathways involved in skeletal muscle homeostasis are altered during aging and have been linked to loss of muscle mass. Moreover, the environmental effects of the sedentary lifestyle of older people further promote and contribute the loss of muscle mass. There are currently no widely accepted therapeutic strategies to halt or reverse the progression of sarcopenia. Caloric restriction has been shown to be beneficial as a sarcopenia and aging antagonist. Such results have made the search for caloric restriction mimetics (CRM) a priority. However given the mechanisms of action, some of the currently investigated CRMs may not combat sarcopenia. Thus, sarcopenia may represent a unique phenotypic feature of aging that requires specific and individually tailored therapeutic strategies.

  13. One size may not fit all: anti-aging therapies and sarcopenia

    OpenAIRE

    Burks, Tyesha N.; Cohn, Ronald D.

    2011-01-01

    Sarcopenia refers to age-related loss of muscle mass and function. Several age-related changes occur in skeletal muscle including a decrease in myofiber size and number and a diminished ability of satellite cells to activate and proliferate upon injury leading to impaired muscle remodeling. Although the molecular mechanisms underlying sarcopenia are unknown, it is tempting to hypothesize that interplay between biological and environmental factors cooperate in a positive feedback cycle contrib...

  14. Anti-aging activities of Pyrus pyrifolia var culta plant callus extract

    African Journals Online (AJOL)

    -aging, Callus extract, Skin lightening, Anti-tyrosinase activity, .... in pore size). One hundred microliters of 0.2 mM. DPPH in methanol were added to 100 µL of each sample solution (ascorbic acid or Pyrus pyrifolia var. culta callus aqueous ...

  15. Lifestyle and nutrition, caloric restriction, mitochondrial health and hormones: Scientific interventions for anti-aging

    Directory of Open Access Journals (Sweden)

    Luis Vitetta

    2008-01-01

    Full Text Available Luis Vitetta1, Bill Anton21Unit of Health Integration, School of Medicine, University of Queensland, Australia; 2Path Lab, Melbourne, AustraliaAbstract: Aging is a universal process to all life forms. The most current and widely accepted definition for aging in humans is that there is a progressive loss of function and energy production that is accompanied by decreasing fertility and increasing mortality with advancing age. The most obvious and commonly recognised consequence of aging and energy decline is a decrease in skeletal muscle function which affects every aspect of human life from the ability to play games, walk and run to chew, swallow and digest food. There is hence a recognised overall decline of an individuals’ fitness for the environment that they occupy. In Westernised countries this decline is gradual and the signs become mostly noticeable after the 5th decade of life and henceforth, where the individual slowly progresses to death over the next three to four decades. Given that the aging process is slow and gradual, it presents with opportunities and options that may ameliorate and improve the overall functional capacity of the organism. Small changes in function may be more amenable and likely to further slow down and possibly reverse some of the deleterious effects of aging, rather, than when the incremental changes are large. This overall effect may then translate into a significant compression of the deleterious aspects of human aging with a resultant increase in human life expectancy.Keywords: human aging, life expectancy, lifespan, energy

  16. Bio-Guided Targeting for Preservative and Anti-Ageing Cosmetic Ingredient Development

    Directory of Open Access Journals (Sweden)

    Emilie Destandau

    2014-01-01

    Full Text Available To develop a new antioxidant, antibacterial and natural cosmetic ingredient without cytotoxicity to skin cells, bioactive molecules contained in Kalanchoe pinnata leaf methanolic extract were targeted using semi-preparative HPLC fractionation linked to biological activity tests. Chromatographic effluent was collected at the column outlet into a 96 deep-well microplate, filling successively all the wells. After freeze-drying, the microplate was ready to use for different biological tests such as antimicrobial activity on microorganisms, skin cell viability and antioxidant activity on human keratinocyte cells. The injection of only 2.64 mg of crude extract into the HPLC system reveals a good correlation between the chromatographic peaks and the different biological activities. One fraction is mainly of interest since good antibacterial and antioxidant activities without cytotoxicity are observed. The analysis of this fraction using mass spectrometry allows the identification of glycoside derivatives of quercetin, isorhamnetin and kaempferol. Thus, a correlation between biological activity and the presence of these flavonoids is obtained. This screening method allows a rapid fractionation associated with a biological activity evaluation and a first molecular identification, saving time by limiting sample treatments and solvent consumption.

  17. Anti-aging activities of extracts from Tunisian medicinal halophytes and their aromatic constituents

    Science.gov (United States)

    Jdey, A.; Falleh, H.; Ben Jannet, S.; Mkadmini Hammi, K.; Dauvergne, X.; Magné, C.; Ksouri, R.

    2017-01-01

    Six medicinal halophytes widely represented in North Africa and commonly used in traditional medicine were screened for pharmacological properties to set out new promising sources of natural ingredients for cosmetic or nutraceutical applications. Thus, Citrullus colocynthis, Cleome arabica, Daemia cordata, Haloxylon articulatum, Pituranthos scoparius and Scorzonera undulata were examined for their in vitro antioxidant (DPPH scavenging and superoxide anion-scavenging, β-carotene bleaching inhibition and iron-reducing tests), antibacterial (microdilution method, against four human pathogenic bacteria) and anti-tyrosinase activities. Besides, their aromatic composition was determined by RP-HPLC. H. articulatum shoot extracts exhibited the strongest antioxidant activity and inhibited efficiently the growth of Salmonella enterica and Escherichia coli. P. scoparius and C. arabica inhibited slightly monophenolase, whereas H. articulatum was the most efficient inhibitor of diphenolase activity. Furthermore, H. articulatum exhibited the highest aromatic content (3.4 % DW), with dopamine as the major compound. These observations suggest that shoot extract of H. articulatum, and to a lesser extent of C. arabica, could be used as antioxidant, antibiotic as well as new natural skin lightening agents. Also, possible implication of aromatic compounds in anti-tyrosinase activity is discussed. PMID:28827992

  18. Circulating endothelial progenitor cells: a new approach to anti-aging medicine?

    Directory of Open Access Journals (Sweden)

    Patel Amit N

    2009-12-01

    Full Text Available Abstract Endothelial dysfunction is associated with major causes of morbidity and mortality, as well as numerous age-related conditions. The possibility of preserving or even rejuvenating endothelial function offers a potent means of preventing/treating some of the most fearful aspects of aging such as loss of mental, cardiovascular, and sexual function. Endothelial precursor cells (EPC provide a continual source of replenishment for damaged or senescent blood vessels. In this review we discuss the biological relevance of circulating EPC in a variety of pathologies in order to build the case that these cells act as an endogenous mechanism of regeneration. Factors controlling EPC mobilization, migration, and function, as well as therapeutic interventions based on mobilization of EPC will be reviewed. We conclude by discussing several clinically-relevant approaches to EPC mobilization and provide preliminary data on a food supplement, Stem-Kine, which enhanced EPC mobilization in human subjects.

  19. In vitro determination of the anti-aging potential of four southern Africa medicinal plants: Poster

    CSIR Research Space (South Africa)

    Ndlovu, G

    2013-09-01

    Full Text Available continent are exposed to the harsh sun and rarely use skin protective agents as they are expensive. It is for this reason that four southern African medicinal plants used indigenously as cosmetics agents and/or exhibited good antioxidant activity in previous...

  20. Coordination of improvement of higher education personnel: regulatory officer field of post-graduate studies in Brazil

    Directory of Open Access Journals (Sweden)

    Rogerio Junior Boratim

    2014-12-01

    Full Text Available This paper aims to present a sociological reflection on the role of the Coordination of Improvement of Higher Education Personnel (CAPES as the regulator that institutionalized the field of postgraduate studies in Brazil with public universities. The methodological and theoretical assumptions underpin the theory of the scientific field of Pierre Bourdieu and seek to demonstrate that the CAPES as a political entity linked to the federal government brokered and legitimized the involvement of the holders of teacher-researchers greater symbolic capital (scientific recognition among peers-competitors , giving them the prerogative to set rules for the evaluation and funding of post-graduate studies. Nevertheless, these legitimate borrowers (dominant in the field of post-graduate consolidated merit system amalgamated by one academic productivism, establishing universities within a performance culture that brings the trailer individualism, utilitarianism and the casualization of labor and relations in the university field.

  1. Hopes against Hobbes: On Authoritarianism, Regime Legitimation and Soft Power with a Review of Richard C. Bush’s Hong Kong in the Shadow of China: Living with the Leviathan (2016

    Directory of Open Access Journals (Sweden)

    Emile Kok-Kheng Yeoh

    2017-08-01

    Full Text Available Richard C. Bush’s Hong Kong in the shadow of China: Living with the Leviathan (2016 represents an important study on post-“Handover” Hong Kong focusing on the making of the 2014 Occupy Campaign and Umbrella Movement and the impact on the coming development in politics, governance and economy of Hong Kong, taking into consideration China’s Hong Kong policy and the response of the Hong Kong people as well as the perspectives of Taiwan and the United States. This article, while reviewing the book, also provides a detailed analysis of the wider implications of the issues the author of the book has raised as regards Hong Kong – as China’s policy approach towards Hong Kong and by extension Taiwan and the struggle of the Hong Kong people, as well as the Taiwan people, to protect the political freedom and democratic rights they aspire to maintain (in the case of Hong Kong and that they have fought hard to secure (in Taiwan have impacts that reach far beyond Hong Kong and Taiwan in the light of the PRC’s current relentless global projection, riding on the wave of her economic miracle, of her hard and so-called “soft” power in a through an intricate nexus of her domestic and foreign policies that not only serves to strengthen domestic governance and enhance international influence but also involves extraterritorial actions to maintain CCP’s one-party authoritarianism.

  2. AMOR Y AUTORIDAD. EJERCICIOS LEGÍTIMOS DEL PODER DE LAS POLICÍAS MUJERES EN SU TRABAJO/Love and authority. Legitimate power exercise of police women at work

    Directory of Open Access Journals (Sweden)

    Sabrina Calandron

    2012-11-01

    Full Text Available Pensar los modos de ejercicio de la autoridad por parte de las mujeres en la policía bonaerense lleva a reflexionar sobre la asociación entre las cualidades y relaciones personales y el poder formalizado puesto en escena en los espacios laborales. Los vínculos, sentimientos y experiencias afectivas introducen orientaciones particulares al devenir de la profesión policial de las personas, especialmente para las mujeres. Ese plus amoroso es vivido, algunas veces, como una obligación personal y, otras, como una estrategia que permite capitalizar las habilidades laborales. El análisis de esta asociación particular es un aporte al estudio de las significaciones y experiencias alrededor de los complejos procesos de ingreso y jerarquización de mujeres en las policías. Porque además de exigir enérgicas adaptaciones a las policías mujeres, provocó modificaciones en la forma de ejercer la profesión más allá del género. Este artículo no pierde de vista cómo se conjugan clivajes sociales diferentes en la dinámica de las relaciones de poder. Los datos analizados han sido construidos con trabajo de campo etnográfico en comisarías de la Policía de la Provincia de Buenos Aires.   Abstract   To think about the ways that women police officers from the Buenos Aires police force exercise authority leads to a reflection of the association between personal qualities and the relationships and institutionalized power taking place in workplaces. Ties, feelings and affective experiences introduce specific guidelines to the future of the police profession, especially for women. This extra love is experienced sometimes as a duty and others as a strategy to capitalize job skills. The analysis of this particular association contributes to the study of meanings and experiences around the complex process of entry of women into the police force; a process that, in addition to demanding energetic adaptations from women police officers, it also brought

  3. Locating Agency in Automated Behaviour and Legitimated Authority

    NARCIS (Netherlands)

    Roy, Surya

    2014-01-01

    Most theoretical concerns regarding capabilities centre on the relationship between structure and agency. While there has been a lot of concentration on how agency is constructed, there is little work on now how agency may be recovered or expressed. Trends in both critical social theory and

  4. Race and Rape: The Black Woman as Legitimate Victim.

    Science.gov (United States)

    Williams, Linda Meyer

    Scientific investigations of the relationship between race and rape have been flawed by the acceptance of official statistics and have been influenced by prevailing myths about rape and race. This paper proposes a theoretical framework for understanding rape and race. The thesis is presented that only the black victim of sexual assault is viewed…

  5. Transnational Governance Arrangements: Legitimate Alternatives to Regulating Nanotechnologies?

    NARCIS (Netherlands)

    Kica, Evisa; Bowman, D.M.

    2013-01-01

    In recent years, the development and the use of engineered nanomaterials have generated many debates on whether these materials should be part of the new or existing regulatory frameworks. The uncertainty, lack of scientific knowledge and rapid expansion of products containing nanomaterials have

  6. Children on hunger strike: child abuse or legitimate protest?

    Science.gov (United States)

    Mok, A.; Nelson, E. A.; Murphy, J.; Hampson, A.; Hendriks, J. H.

    1996-01-01

    The issue of children on hunger strike (voluntary total fasting) has not been reported before. The World Medical Association Declaration of Tokyo 1975 and the Declaration of Malta 1991 (revised 1992) provide clinicians with guidelines for the management of adult patients on hunger strike but do not mention children. We report the management of 14 Vietnamese children, aged 1 to 12 years, who took part in a hunger strike at a refugee detention centre in Hong Kong. PMID:8597690

  7. Nonviolent Civil Disobedience: Creating Legitimate Regime Change in Iran

    National Research Council Canada - National Science Library

    Selman, Jr, John T

    2007-01-01

    .... These transitions were hastened by nonviolent civil disobedience. Although nonviolent civil disobedience is a common form of political action throughout the world, many political observers do not understand its nature and often underestimate its effect...

  8. A future for the doctrine of substantive legitimate expectation? The ...

    African Journals Online (AJOL)

    Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 18, No 1 (2015) >. Log in or Register to get access to full text downloads.

  9. Children on hunger strike: child abuse or legitimate protest?

    OpenAIRE

    Mok, A.; Nelson, E. A.; Murphy, J.; Hampson, A.; Hendriks, J. H.

    1996-01-01

    The issue of children on hunger strike (voluntary total fasting) has not been reported before. The World Medical Association Declaration of Tokyo 1975 and the Declaration of Malta 1991 (revised 1992) provide clinicians with guidelines for the management of adult patients on hunger strike but do not mention children. We report the management of 14 Vietnamese children, aged 1 to 12 years, who took part in a hunger strike at a refugee detention centre in Hong Kong.

  10. The Economic Action Group: Transformation to a Legitimate Economy

    National Research Council Canada - National Science Library

    Bisenieks, Alan D

    2006-01-01

    .... Terrorism cannot be solved with military assets alone. The Global War on Terrorism (GWOT) has forced operational commanders to tackle a problem requiring extensive cooperation throughout government agencies...

  11. Legitimate lies : The relationship between omission, commission, and cheating

    NARCIS (Netherlands)

    Pittarello, Andrea; Rubaltelli, Enrico; Motro, Daphna

    Across four experiments, we show that when people can serve their self-interest, they are more likely to refrain from reporting the truth ( lie of omission) than actively lie ( lie of commission). We developed a novel online "Heads or Tails" task in which participants can lie to win a monetary

  12. Globalization and new colonialities legitimization. Eight essential issues for debate

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Rulli

    2016-04-01

    Full Text Available The weakness of liberalism, the mirage of development, the new imperial units for Latin America and the role of the left are part of a necessary reflection. The article proposes a signaling point of the core issues of social structure that left extractivism in our region. The weakness of liberalism, the mirage of development, the new imperial units for Latin America and the role of the left are part of a necessary reflection.

  13. Building a Legitimate and Accountable State in South Sudan ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    identify how levels of inclusivity affect the viability of the peace process in South Sudan;; examine the extent to which formal and informal political institutions that are part of the CPA process were inclusive in their creation and evolution;; examine the relationship between the inclusivity of formal and informal political ...

  14. Politisk brug af historien og legitimering af nutiden i Jugoslavien

    DEFF Research Database (Denmark)

    Humlebæk, Carsten

    2014-01-01

    Anmeldelse af: Tea Sindbæk: Usable History? Representations of Yugoslavia’s difϔicult past from 1945 to 2002, Aarhus University Press 2013.......Anmeldelse af: Tea Sindbæk: Usable History? Representations of Yugoslavia’s difϔicult past from 1945 to 2002, Aarhus University Press 2013....

  15. of Discourse: Online Legitimations on the Outbreak of Ebola Virus ...

    African Journals Online (AJOL)

    info

    We use the term “eboliticization” to describe the various ideologically mediated discourses constructed by individuals ..... out the name of God, this country has long had a history of utmost charity, giving money and charity to help others, even .... The only thing Dems really care about is. Gay rights, gay marriage and abortion.

  16. Investigative Journalism and the Legitimation of Moral Order.

    Science.gov (United States)

    Glasser, Theodore L.; Ettema, James S.

    Investigative journalists long have had an adversarial relationship with powerful institutions and those in public office, stemming from the "righteously indignant" reporters of the early nineteenth century penny presses who guarded the interests of the public. Currently, investigative journalists are in a difficult position if they have…

  17. D. Apter (ed.). The Legitimation of Violence | Wood | African ...

    African Journals Online (AJOL)

    African Sociological Review / Revue Africaine de Sociologie. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 4, No 1 (2000) >. Log in or Register to get access to full text downloads.

  18. Doing Machismo: Legitimating speech acts as a selection discourse

    NARCIS (Netherlands)

    Stobbe, J.M.

    2005-01-01

    This article explores the relationship between machismo and implicit power processes at a conceptual and empirical level. Implicit power processes are the taken-for-granted ways in which organizational members reproduce sexual divisions in their organizations. The empirical data are derived from the

  19. China in search of 'legitimate' great power intervention

    DEFF Research Database (Denmark)

    Sørensen, Camilla T. N.

    2016-01-01

    Thanks to Beijing’s expanding global role and interests, it is no longer possible for China to follow its traditional ‘lay low’ [tao guang yang hui] strategy and the traditionally rather strict interpretation of the principle of non-intervention. Consequently, among Chinese International Relations...

  20. Nonviolent Civil Disobedience: Creating Legitimate Regime Change in Iran

    Science.gov (United States)

    2007-07-02

    population in solidarity and indicated to General Pinochet that he could no longer rule through fear.24 Bell ringing visibly shaped solidarity for the...dictator Augusto Pinochet , have resorted to torture, incarceration, and mass murder but, they, nevertheless, were defeated by non-violent groups of...government’s brutality. General Pinochet of Chile was brutal, but toppled. Nonviolent leaders were assassinated in South Africa yet the nonviolent

  1. Legitimating Lived Curriculum: Towards a Curricular Landscape of Multiplicity.

    Science.gov (United States)

    Aoki, Ted T.

    1993-01-01

    Contrasts the instrumental character of traditional curriculum plans with the retextured curricular landscape inhabited by a hypothetical fifth-grade teacher struggling to help individual students learn. The idea is to teach science as a humanity, so that a privileged technoscientific mindset can be demystified and the multiplicity of human…

  2. Do we act on an ethically legitimate basis?

    International Nuclear Information System (INIS)

    Maier-Leibnitz, H.

    1987-01-01

    The question is discussed by several contributions by different authors put together for this issue of 'et', and the aspects under review range from public acceptance of technology in general to the role of scientists in making their view of technology, and nuclear technology in particular, understandable. The discussion elaborates the subject from the technical and political point of view and from the point of view of theology and ethics. (UA) [de

  3. Science as a Model for Rational, Legitimate Government

    Science.gov (United States)

    Branscomb, Lewis

    2009-05-01

    Before WWII science was largely dependent on support through teaching, and a few foundations. In the last half century, thanks to the contribution of applied science to winning the second world war, government became a deep-pockets source of support for science. While many academic scientists were deeply suspicious of government as a sponsor, the research universities saw an opportunity to build their institutions around government support. Government saw science as a means for sustaining its military primacy. Thus a marriage was consummated by partners -- science and politics -- who needed each other, but for quite different and to some degree conflicting motives. In the U.S. democracy, the relationship between science and politics has never been easy. The search for truth in science and for legitimacy in politics both require systems for generating public trust, but these systems are not the same, and indeed they are often incompatible. The most profound area of mismatch between science and politics is found not in conflicts over what kinds of research are deserving of public funding, but rather in conflicts over the advice government receives from scientific and technical experts. It is no accident that democratic America fostered progress in science and technology. Both American democracy and modern science are products of the Enlightenment, with its emphasis on reason and openness rather than on prejudice and traditional authority. American democracy has always benefited from a pragmatic willingness to learn from experience, very much as science relies on experiment. Progress in science is based transparency and accountability; these are also basic principles of democratic government. If science is corrupted by government, government itself is in danger of becoming corrupt. In recent years we seemed to be going down that path. It is no accident that President Obama and media commentators speak often of the ``new pragmatism,'' or that he appointed exceptionally well-qualified scientists to top posts in his government. Both democracy and science stand to benefit enormously when our political leaders understand that the ethos of science and ethics of democracy have common roots.

  4. discourse of knowledge versus discourse of self-legitimation

    African Journals Online (AJOL)

    DR. KAMALU

    2016-06-02

    Jun 2, 2016 ... as the author, publishers, printers, promoters, and distributors. Pamphlet publishing became a lucrative industry especially in the 1960s. The printing of the pamphlets which originally began in Onitsha later spread to several parts of the country like Aba, Port Harcourt, Enugu, and even parts of the defunct ...

  5. of Discourse: Online Legitimations on the Outbreak of Ebola Virus ...

    African Journals Online (AJOL)

    info

    responses to it motivated discourses that are political, religious and racist in orientation. Internet postings on the disease reveal real or imaginary activation of what Charteris-. Black calls “culturally based schema of what constitutes sources of fear and forms of social menace” (2005, p. 24). Thus the socio-political perception ...

  6. FLoc: Dependable Link Access for Legitimate Traffic in Flooding Attacks

    Science.gov (United States)

    2011-11-23

    IPD , Si,KRj ). The router writes the capability in the client’s connection request packet (e.g., TCP - SYN ) to the server. Thus, a router issues an...acknowledgement (e.g., TCP - SYN /ACK). In Fig. 1, the flow identifier fi at Rj is the capability Cj since Cj can only be authenticated by the Rj . These capabilities...access in flooding attacks. A. Token-Bucket Model Revisited We first review the standard TCP congestion-control mech- anism and the aggregate traffic

  7. Consumo y dinero: transacciones legítimas, acuerdos y conflictos interpersonales en un programa de microcréditos Consumo e dinheiro: transações legítimas, acordos e conflitos interpessoais em um programa de microcrédito Consumption and money: legitimate transactions, agreements and interpersonal conflicts in a microcredit program

    Directory of Open Access Journals (Sweden)

    Adrián Koberwein

    2011-12-01

    Full Text Available El objetivo del presente artículo es analizar la producción de transacciones legítimas en una política social de microcrédito e indagar en la generación de acuerdos y conflictos interpersonales relacionados con las transacciones. Adoptamos un enfoque eminentemente etnográfico y nos centramos en los sentidos que los actores le otorgan al uso y a la asignación de dinero, enfatizando en la creación y expresión de las deudas así como en las obligaciones tanto "económicas" como "no económicas".Este artigo pretende analisar a produção de transações legítimas em uma política social de microcrédito e abordar a criação de acordos e conflitos interpessoais relacionados a essas transacções. Adotando uma abordagem eminentemente etnográfica, nos centraremos nos sentidos que os atores atribuem ao uso e alocação de dinheiro enfatizando a análise dos modos em que as dívidas são criadas e expressas, como também as obrigações tanto "econômicas" como "não econômicas".The objective of this paper is to analyze the production of legitimate transactions in a microcredit policy and to explore the creation of interpersonal agreements and conflicts related to these transactions. Based on an ethnographic approach, the paper focuses on the meanings that actors give to the allocation of money, emphasizing the creation as well as the expression of both 'economic' and 'non-economic' debts and obligations.

  8. A educação na 'Constelação pós-nacional': o enfraquecimento da legitimação e do controle democrático, "expertocrático" e ético-profissional Education in the 'Postnational Constellation': the weakening of democratic, expertocratic and ethicoprofessional legitimation and control

    Directory of Open Access Journals (Sweden)

    Frank-Olaf Radtke

    2010-04-01

    organizations in educational issues marks a transition to a "postnational constellation" also in the education field insofar as the national educational sovereignty is being at least readjusted. The economization of education policy is however not restricted to bringing education closer to the needs of the economy and to turning its services into tradable goods. Rather, it also impinges on the operative level of education. A logics of production is being implemented in the self-description of the institutions of the education system, which are no longer bureaucratically administered establishments, but are rather conceived of as managerially conducted production business in which entrepreneurial action is needed. This new governance raises the problem of democratic legitimation of political decisions which ideally combines three elements: democratic, expertocratic, and ethico-professional. The article discusses the consequences of a shift in the balance of the three components with reference to Germany.

  9. Educational Films as Part of Study Materials for Vulnerable Target Groups

    Directory of Open Access Journals (Sweden)

    Petra Javrh

    2013-12-01

    Full Text Available The paper presents theoretical approaches to special, didactically augmented visual and audio study materials for adults. We also define the narrow sense of the concept of an educational film as a well-rounded visual material that is structured didactically and contains inherent educational goals both in its design and application. The use of the word “film” instead of “video” is legitimized by fulfilling the condition of being a semantically complete and well-rounded product. In the conclusion, we present the findings obtained in Slovenia through experience and practice in the education of vulnerable groups of adults by employing such didactic materials.

  10. Changing psychology: history and legacy of the Society for the Psychological Study of Ethnic Minority Issues.

    Science.gov (United States)

    Comas-Díaz, Lillian

    2009-10-01

    The history and legacy of the Society for the Psychological Study of Ethnic Minority Issues (American Psychological Association Division 45) for its first 20 years are reviewed. The legitimization of the ethnic minority scholarship within organized psychology is chronicled, highlighting the central role of advocacy and activism. Multiculturalism is presented as a paradigm for the globalization of the United States. It is concluded that ethnic minority psychology has changed the field and equips us for the challenges of the internationalization of the world. Copyright 2009 APA, all rights reserved.

  11. Anti-aging Effect of Transplanted Amniotic Membrane Mesenchymal Stem Cells in a Premature Aging Model of Bmi-1 Deficiency

    Science.gov (United States)

    Xie, Chunfeng; Jin, Jianliang; Lv, Xianhui; Tao, Jianguo; Wang, Rong; Miao, Dengshun

    2015-01-01

    To determine whether transplanted amniotic membrane mesenchymal stem cells (AMSCs) ameliorated the premature senescent phenotype of Bmi-1-deficient mice, postnatal 2-day-old Bmi-1−/− mice were injected intraperitoneally with the second-passage AMSCs from amniotic membranes of β-galactosidase (β-gal) transgenic mice or wild-type (WT) mice labeled with DiI. Three reinjections were given, once every seven days. Phenotypes of 5-week-old β-gal+ AMSC-transplanted or 6-week-old DiI+ AMSC-transplanted Bmi-1−/− mice were compared with vehicle-transplanted Bmi-1−/− and WT mice. Vehicle-transplanted Bmi-1−/− mice displayed growth retardation and premature aging with decreased cell proliferation and increased cell apoptosis; a decreased ratio and dysmaturity of lymphocytic series; premature osteoporosis with reduced osteogenesis and increased adipogenesis; redox imbalance and DNA damage in multiple organs. Transplanted AMSCs carried Bmi-1 migrated into multiple organs, proliferated and differentiated into multiple tissue cells, promoted growth and delayed senescence in Bmi-1−/− transplant recipients. The dysmaturity of lymphocytic series were ameliorated, premature osteoporosis were rescued by promoting osteogenesis and inhibiting adipogenesis, the oxidative stress and DNA damage in multiple organs were inhibited by the AMSC transplantation in Bmi-1−/− mice. These findings indicate that AMSC transplantation ameliorated the premature senescent phenotype of Bmi-1-deficient mice and could be a novel therapy to delay aging and prevent aging-associated degenerative diseases. PMID:26370922

  12. Protein Reporter Bioassay Systems for the Phenotypic Screening of Candidate Drugs: A Mouse Platform for Anti-Aging Drug Screening

    Directory of Open Access Journals (Sweden)

    Isao Shimokawa

    2012-02-01

    Full Text Available Recent drug discovery efforts have utilized high throughput screening (HTS of large chemical libraries to identify compounds that modify the activity of discrete molecular targets. The molecular target approach to drug screening is widely used in the pharmaceutical and biotechnology industries, because of the amount of knowledge now available regarding protein structure that has been obtained by computer simulation. The molecular target approach requires that the structure of target molecules, and an understanding of their physiological functions, is known. This approach to drug discovery may, however, limit the identification of novel drugs. As an alternative, the phenotypic- or pathway-screening approach to drug discovery is gaining popularity, particularly in the academic sector. This approach not only provides the opportunity to identify promising drug candidates, but also enables novel information regarding biological pathways to be unveiled. Reporter assays are a powerful tool for the phenotypic screening of compound libraries. Of the various reporter genes that can be used in such assays, those encoding secreted proteins enable the screening of hit molecules in both living cells and animals. Cell- and animal-based screens enable simultaneous evaluation of drug metabolism or toxicity with biological activity. Therefore, drug candidates identified in these screens may have increased biological efficacy and a lower risk of side effects in humans. In this article, we review the reporter bioassay systems available for phenotypic drug discovery.

  13. [Aging and homeostasis. Development of novel AdipoR-targeted drugs with exercise-mimicking and anti-aging properties.

    Science.gov (United States)

    Okada-Iwabu, Miki; Yamauchi, Toshimasa; Iwabu, Masato; Kadowaki, Takashi

    We have so far clarified that adiponectin, an adipocyte-secreted physiologically active substance, is decreased with the onset of obesity and that lifestyle-related diseases are primarily accounted for by the systemically decreased action of adiponectin/adiponectin receptors(AdipoRs). The activation of adiponectin/AdipoR has caloric restrictive and exercise-mimicking effects thus prolonging lifespan. We were the first in the world to succeed in identifying small-molecule compounds that serve as seed compounds for candidate AdipoR-activating drugs. Moreover, we have also reported the crystal structures of AdipoRs. It is hoped that these milestones will accelerate our efforts at AdipoR structure-based drug discovery leading to the development of novel AdipoR-targeted anti-diabetic drugs with promising life-prolonging properties.

  14. Formulasi dan Efektivitas Sebagai Anti-Aging dari Masker Wajah yang Mengandung Minyak Almond (Prunus amygdalus dulcis)

    OpenAIRE

    Stephanie

    2015-01-01

    The ultraviolet light, air pollution and factors that causes free radicals can lead to skin aging. The damage that caused from free radicals can cause skin tissue becomes tight and inflexible as the initial formation of wrinkles. Antioxidant that is found from Vitamin E, oleic acid and stearic acid from Henry Lamotte almond oil is believed can slower the effect of aging. Facial mask is chosen for this research because of its capability to repair skin cells and slower premature aging. The aim ...

  15. Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle.

    Science.gov (United States)

    Zullo, Alberto; Simone, Emanuela; Grimaldi, Maddalena; Musto, Vincenzina; Mancini, Francesco Paolo

    2018-03-21

    Fighting diseases and controlling the signs of ageing are the major goals of biomedicine. Sirtuins, enzymes with mainly deacetylating activity, could be pivotal targets of novel preventive and therapeutic strategies to reach such aims. Scientific proofs are accumulating in experimental models, but, to a minor extent, also in humans, that the ancient practice of calorie restriction could prove an effective way to prevent several degenerative diseases and to postpone the detrimental signs of ageing. In the present review, we summarize the evidence about the central role of sirtuins in mediating the beneficial effects of calorie restriction in skeletal and cardiac muscle since these tissues are greatly damaged by diseases and advancing years. Moreover, we entertain the possibility that the identification of sirtuin activators that mimic calorie restriction could provide the benefits without the inconvenience of this dietary style.

  16. Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries

    Science.gov (United States)

    2014-01-01

    Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality in modern societies, and advancing age is the major risk factor for CVD. Arterial dysfunction, characterized by large elastic artery stiffening and endothelial dysfunction, is the key event leading to age-associated CVD. Our work shows that regular aerobic exercise inhibits large elastic artery stiffening with aging (optimizes arterial compliance) and preserves endothelial function. Importantly, among previously sedentary late middle-aged and older adults, aerobic exercise improves arterial stiffness and enhances endothelial function in most groups and, therefore, also can be considered a treatment for age-associated arterial dysfunction. The mechanisms by which regular aerobic exercise destiffens large elastic arteries are incompletely understood, but existing evidence suggests that reductions in oxidative stress associated with decreases in both adventitial collagen (fibrosis) and advanced glycation end-products (structural protein cross-linking molecules), play a key role. Aerobic exercise preserves endothelial function with aging by maintaining nitric oxide bioavailability via suppression of excessive superoxide-associated oxidative stress, and by inhibiting the development of chronic low-grade vascular inflammation. Recent work from our laboratory supports the novel hypothesis that aerobic exercise may exert these beneficial effects by directly inducing protection to aging arteries against multiple adverse factors to which they are chronically exposed. Regular aerobic exercise should be viewed as a “first line” strategy for prevention and treatment of arterial aging and a vital component of a contemporary public health approach for reducing the projected increase in population CVD burden. PMID:24855137

  17. Using "anti-ageing" to market cosmetic surgery: just good business, or another wrinkle on the face of medical practice?

    Science.gov (United States)

    Ring, Anne L

    2002-06-17

    Potential consequences of the deregulation of advertising by doctors are examined using the example of practitioners who promote cosmetic procedures by exploiting body image concerns in a society that is both ageing and youth-oriented.

  18. Chitin-hyaluronan nanoparticles: a multifunctional carrier to deliver anti-aging active ingredients through the skin

    Czech Academy of Sciences Publication Activity Database

    Morganti, P.; Palombo, M.; Tishchenko, Galina; Yudin, V. E.; Guarneri, F.; Cardillo, M.; Del Ciotto, P.; Carezzi, F.; Morganti, G.; Fabrizi, G.

    2014-01-01

    Roč. 1, č. 3 (2014), s. 140-158 ISSN 2079-9284 EU Projects: European Commission(XE) 315233 - N-CHITOPACK Institutional support: RVO:61389013 Keywords : chitin nanofibrils * skin aging emulsions * innovative beauty masks Subject RIV: CD - Macromolecular Chemistry

  19. Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle

    Directory of Open Access Journals (Sweden)

    Alberto Zullo

    2018-03-01

    Full Text Available Fighting diseases and controlling the signs of ageing are the major goals of biomedicine. Sirtuins, enzymes with mainly deacetylating activity, could be pivotal targets of novel preventive and therapeutic strategies to reach such aims. Scientific proofs are accumulating in experimental models, but, to a minor extent, also in humans, that the ancient practice of calorie restriction could prove an effective way to prevent several degenerative diseases and to postpone the detrimental signs of ageing. In the present review, we summarize the evidence about the central role of sirtuins in mediating the beneficial effects of calorie restriction in skeletal and cardiac muscle since these tissues are greatly damaged by diseases and advancing years. Moreover, we entertain the possibility that the identification of sirtuin activators that mimic calorie restriction could provide the benefits without the inconvenience of this dietary style.

  20. Staff perceptions on patient motives for attending GP-led urgent care centres in London: a qualitative study.

    Science.gov (United States)

    Greenfield, Geva; Ignatowicz, Agnieszka; Gnani, Shamini; Bucktowonsing, Medhavi; Ladbrooke, Tim; Millington, Hugh; Car, Josip; Majeed, Azeem

    2016-01-14

    General practitioner (GP)-led urgent care centres were established to meet the growing demand for urgent care. Staff members working in such centres are central in influencing patients' choices about which services they use, but little is known about staff perceptions of patients' motives for attending urgent care. We hence aimed to explore their perceptions of patients' motives for attending such centres. A phenomenological, qualitative study, including semistructured interviews. The interviews were analysed using thematic content analysis. 2 GP-led urgent care centres in 2 academic hospitals in London. 15 staff members working at the centres including 8 GPs, 5 emergency nurse practitioners and 2 receptionists. We identified 4 main themes: 'Confusion about choices', 'As if increase of appetite had grown; By what it fed on', 'Overt reasons, covert motives' and 'A question of legitimacy'. The participants thought that the centres introduce convenient and fast access for patients. So convenient, that an increasing number of patients use them as a regular alternative to their community GP. The participants perceived that patients attend the centres because they are anxious about their symptoms and view them as serious, cannot get an appointment with their GP quickly and conveniently, are dissatisfied with the GP, or lack self-care skills. Staff members perceived some motives as legitimate (an acute health need and difficulties in getting an appointment), and others as less legitimate (convenience, minor illness, and seeking quicker access to hospital facilities). The participants perceived that patients attend urgent care centres because of the convenience of access relative to primary care, as well as sense of acuity and anxiety, lack self-care skills and other reasons. They perceived some motives as more legitimate than others. Attention to unmet needs in primary care can help in promoting balanced access to urgent care. Published by the BMJ Publishing Group Limited

  1. Comparative Study of Professional vs Mass Market Topical Products for Treatment of Facial Photodamage.

    Science.gov (United States)

    Reich, Hilary; Wallander, Irmina; Schulte, Lacie; Goodier, Molly; Zelickson, Brian

    2016-01-01

    Many over the counter topical products claim to reverse the signs of cutaneous photo-damage. To date, the two most studied ingredients for improving the texture, tone, and pigmentation of the skin are topical retinoids and hydroquinone. This split face study compares a mass market skincare regimen with a prescription skin care regimen for improvement in photo damaged skin. Twenty-seven subjects with moderate photo damaged facial skin were enrolled. Each subject was consented and assigned with the mass market anti-aging system (Treatment A) to one side of the face and the prescription anti-aging system (Treatment B or Treatment C) to the other side of the face. Treatment B contained 13 subjects whom did not use 0.025% Retinol cream. Treatment C contained 14 subjects who used a 0.025% Retinol Cream. Subjects had 4 visits over 12 weeks for digital photography and surveys. Photographs were evaluated by blinded physicians. Physician objective analysis showed all three systems to have a statistically significant clinical improvement in photoaged skin seen in as little as 4 weeks of use. Participant's surveys rated the mass market system higher than both of the professional systems for visible skin changes, ease of use, and likelihood to recommend to a friend. Twelve of twenty-seven subjects preferred the mass market system for overall improvement while twelve thought each system gave the same improvement. This study demonstrates that a mass marketed skin care system can give similar clinical improvements in photo-aged skin as a professionally dispensed prescription system and the majority of participants preferred the mass-marketed system.

  2. Public political thought: bridging the sociological-philosophical divide in the study of legitimacy.

    Science.gov (United States)

    Abulof, Uriel

    2016-06-01

    The study of political legitimacy is divided between prescriptive and descriptive approaches. Political philosophy regards legitimacy as principled justification, sociology regards legitimacy as public support. However, all people can, and occasionally do engage in morally reasoning their political life. This paper thus submits that in studying socio-political legitimation - the legitimacy-making process - the philosophical ought and the sociological is can be bridged. I call this construct 'public political thought' (PPT), signifying the public's principled moral reasoning of politics, which need not be democratic or liberal. The paper lays PPT's foundations and identifies its 'builders' and 'building blocks'. I propose that the edifice of PPT is built by moral agents constructing and construing socio-moral order (nomization). PPT's building blocks are justificatory common beliefs (doxa) and the deliberative language of legitimation. I illustrate the merits of this groundwork through two empirical puzzles: the end of apartheid and the emergence of Québécois identity. © London School of Economics and Political Science 2016.

  3. Optical coherence tomography applied to tests of skin care products in humans--a case study.

    Science.gov (United States)

    Vasquez-Pinto, L M C; Maldonado, E P; Raele, M P; Amaral, M M; de Freitas, A Z

    2015-02-01

    When evaluating skin care products for human skin, quantitative test methods need to be simple, precise and reliable. Optical coherence tomography (OCT), provides high-resolution sectional images of translucent materials to a depth of a few millimeters, a technique usually applied to medical measurements in ophthalmology and dermatology. This study aimed to demonstrate the application of OCT as the main technique for monitoring changes in skin topography during tests of a wrinkle-reduction product in humans. We used a commercial OCT apparatus to perform clinical examinations of skin roughness in treated and non-treated sites in the periorbital region of thirty human voluntaries who were using an anti-aging product commercially available: Natura Chronos® Flavonóides de Passiflora 45+ FPS15, from Natura Cosméticos, Brazil. Measurements were performed days 0, 7, 14 and 28 of treatment. Equipment and software allowed real-time recording of skin roughness parameters and wrinkle depths. The OCT measurements have allowed the monitoring of changes in skin roughness, which have shown reduction in treated sites around 10%. The obtained depth distributions also indicate reduction in the occurrence of wrinkles deeper than 170 μm. The verified results are consistent with those typically obtained after successful treatment with modern anti-aging products. By using the OCT technique, it was possible to quantify changes in skin roughness and in the distribution of depths of skin wrinkles, with adequate sensitivity. OCT imaging allows the direct visualization of the skin topography with resolution of micrometers, a reliable and interactive tool for clinical use. Therefore, for the first time, we demonstrated the use of OCT technique to verify the efficacy of cosmetic products in real time. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. How to study the history of European law?

    DEFF Research Database (Denmark)

    Rasmussen, Morten

    on how a general history of European law should be written and in particular how to avoid the pitfalls that characterises mainstream research on European law. In the first part it is argued that the ‘constitutionalisation’ of European law was promoted by a broad coalition beyond the Court of Justice...... constituted by the Commission’s legal service, transnationally organised pro-European jurists and the European Parliament. When the Court of Justice in the two key judgments, Van Gend en Loos (1963) and Costa V. ENEL (1964), took the decisive steps to transform European law into a semi-federal legal order...... the emerging academic field of European law was deeply involved in legitimating the jurisprudence of the Court of Justice in the 1960s. In the second part of the article, the starting point is to place mainstream legal and political science studies of European law in a historical perspective in order...

  5. Clinical significance of an elevated ankle-brachial index differs depending on the amount of appendicular muscle mass: the J-SHIPP and Nagahama studies.

    Science.gov (United States)

    Tabara, Yasuharu; Igase, Michiya; Setoh, Kazuya; Kawaguchi, Takahisa; Okada, Yoko; Ohara, Maya; Takahashi, Yoshimitsu; Kosugi, Shinji; Ohyagi, Yasumasa; Miki, Tetsuro; Nakayama, Takeo; Kohara, Katsuhiko; Matsuda, Fumihiko

    2018-02-28

    Clinical implication of a high ankle-brachial index (ABI) is not well known. Based on our previous study, we suspected that body composition may be a determinant of a high ABI and may consequently modulate the clinical significance of a high ABI. Datasets of two studies with independent cohorts, the anti-aging study cohort (n = 1765) and the Nagahama study cohort (n = 8,039), were analyzed in this study, in which appendicular muscle mass was measured by computed tomography and bioelectrical impedance analysis, respectively. Brachial and ankle blood pressures were measured using a cuff-oscillometric method. In the anti-aging study cohort, thigh muscle area (β = 0.387, p < 0.001), but not fat area, showed a strong positive association with the ABI independent of the body mass index (p = 0.662) and other possible covariates, including systolic brachial blood pressure (p = 0.054), carotid hypertrophy (p = 0.559), and arterial stiffness (β = 0.102, p = 0.001). This positive association was replicated in the Nagahama cohort. When the subjects were subdivided by the 75th percentiles of the ABI and appendicular muscle mass, multinomial logistic regression analysis identified insulin resistance as an independent determinant of an elevated ABI in subjects with normal muscle mass (coefficient = 0.134, p = 0.010), whereas insulin resistance was inversely associated with an elevated ABI in subjects with high muscle mass (coefficient = -0.268, p = 0.001). Appendicular muscle mass was a strong determinant of the ABI. The clinical background, particularly insulin resistance, of individuals with an elevated ABI may differ based on the amount of muscle mass.

  6. Social participation in young people with nonepileptic seizures (NES): A qualitative study of managing legitimacy in everyday life.

    Science.gov (United States)

    Karterud, Hilde Nordahl; Haavet, Ole Rikard; Risør, Mette Bech

    2016-04-01

    This qualitative study explored social participation in young people with nonepileptic seizures (NES), particularly how legitimacy of illness is managed in everyday life. Young people with NES, all female and aged between 14 and 24 years (N=11), were interviewed and followed up over a 14-month period. The transcripts were analyzed using thematic analysis. Four main themes were elaborated: 1) Delegitimizing experiences from families, schoolteachers, colleagues, and employers were part of everyday life. 2) Fear of being exposed to delegitimizing events resulted in the young people trying to conceal the diagnosis; for some, this resulted in isolation from all social arenas, apart from their closest relationships. 3) Support from close relationships was protective against delegitimization and contributed towards greater social participation. 4) Perceiving NES as a legitimate disorder contributed to increased social participation. We found a relationship between legitimacy of illness experienced by the participants and the extent to which they either participated or retreated socially. Those who had an illness perception that was personally meaningful experienced their condition as being more legitimate and participated more socially. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. National policy for integration of ICT: a comparative study between Brazil and Spain

    Directory of Open Access Journals (Sweden)

    José GOMES DA SILVA

    2018-01-01

    Full Text Available This article aims to present the results of a comparative study of national educative policies for integration of information and communication technologies (ICT used in basic education schools in Brazil and Spain. In general terms, this article intends to examine possible convergences and divergences in objectives presented by these policies. The time frame was between 1997 and 2010, when these policies and the launch of new transnational policies for ICT integration began. The research has a qualitative approach and a descriptive and documentary procedure, through the comparative study method. The sources were laws, resolutions, regulations, decrees, regulatory guidelines, official informs, official communications and technical reports. So, on the whole, we ascertained that these policies seek an educational quality, aligned by the market logic, with constitutive elements of the recommendations of international organisations, and they are directed to the technological development and economic growth, thus legitimizing the hegemonic discourse of globalization.

  8. Tea and Health: Studies in Humans

    Science.gov (United States)

    Khan, Naghma; Mukhtar, Hasan

    2014-01-01

    Tea, next to water is the cheapest beverage humans consume. Drinking the beverage tea has been considered a health-promoting habit since ancient times. The modern medicinal research is providing a scientific basis for this belief. The evidence supporting the health benefits of tea drinking grows stronger with each new study that is published in the scientific literature. Tea plant Camellia sinensis has been cultivated for thousands of years and its leaves have been used for medicinal purposes. Tea is used as a popular beverage worldwide and its ingredients are now finding medicinal benefits. Encouraging data showing cancer-preventive effects of green tea from cell-culture, animal and human studies have emerged. Evidence is accumulating that black tea may have similar beneficial effects. Tea consumption has also been shown to be useful for prevention of many debilitating human diseases that include maintenance of cardiovascular and metabolic health. Various studies suggest that polyphenolic compounds present in green and black tea are associated with beneficial effects in prevention of cardiovascular diseases, particularly of atherosclerosis and coronary heart disease. In addition, anti-aging, antidiabetic and many other health beneficial effects associated with tea consumption are described. Evidence is accumulating that catechins and theaflavins, which are the main polyphenolic compounds of green and black tea, respectively, are responsible for most of the physiological effects of tea. This article describes the evidences from clinical and epidemiological studies in the prevention of chronic diseases like cancer and cardiovascular diseases and general health promotion associated with tea consumption. PMID:23448443

  9. Scintigraphic disagreement in the study of thyroid nodules using technetium 99m and iodine 131

    International Nuclear Information System (INIS)

    Planchon, C.A.

    1977-01-01

    116 patients with thyroid nodules, iso or hyperfixing, heterogeneous or scintigraphically indistinct after administration of pertechnetate 99mTc, were systematically re-examined with iodine 131. The results of this study are as follows: 1) 99mTc, while its advantages justify its extensive application, is an imperfect tracer and cannot replace iodine 131 altogether. In fact in 12% of the cases the results were conflicting. 2) The technological conditions may sometimes be to blame but the hypothesis of a special metabolic behavior of the nodule examined seems plausible in certain cases of disagreement (blocking of hormone synthesis and escape of non-hormonal iodine). 3) These observations correspond to no particular anatomo-clinical factors. The legitimate conclusion therefore is that the exclusive use of 99mTc could result in failure to recognise a non-functional nodule (1 case in about 10), a possibility not to be neglected because of the risk of cancer [fr

  10. SECT STUDIES IN USSR: TERMINOLOGY AND APPROACHES

    Directory of Open Access Journals (Sweden)

    Roman Safronov

    2013-10-01

    Full Text Available The main theme of the article is sect studies in USSR. Soviet tradition in the fi eld did not appear from the thin air but was a «dialectic» — in the sense that simultaneously and legitimately can be estimated as continuation and rejection — sequel of pre-Soviet sect-study approach. Soviet tradition per se is based on ambiguous — according to Lenin’s position — understanding of sectarianism as an example of class combat (positive dimension but religiously specific (negative dimension. This negative attitude was expressed in specific ideological and political position towards sectarianism. Stating this position was a priority and that is why the establishing of proper Soviet scientifi c approach was problematic. It began to form only in the 1960-s. The term «sect» for both pre-Soviet and Soviet researches had negative connotation in dogmatic way for the former and in ideological way for the latter. Such a long history of negative understanding of the term makes it very hard to understand it as a neutral in contemporary Russia

  11. Finding God in Wellworth High School: More Legitimations of Story-Making as Research

    Science.gov (United States)

    Clough, Peter

    2009-01-01

    A curious piece of ironic, partially-dramatised auto/ethnography, this paper reflects an ongoing attempt to explore the vapid certainties of my own faith, some of the brittle discomforts of contemporary schooling, and the possibilities of a social science research methodology which can artfully assemble on the same stage belief, empirics and…

  12. Legitimate Use of Military Force Against State-Sponsored International Terrorism

    Science.gov (United States)

    1989-07-01

    RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18...embassy (which was occupied by arm-at militants) was burned and 39 persons died, including 32 of the 33 hostages. Only the Spanish ambassador survived...aviation accidents, when on 27 March 1977, two 747 jets collided at Tenerife Airport, Canary Islands. The two aircraft had been diverted from Las Palmas

  13. The thorny road to technology legitimation - Institutional work for potable water reuse in California

    NARCIS (Netherlands)

    Binz, Christian; Harris-Lovett, Sasha; Kiparsky, Michael; Sedlak, David L.; Truffer, Bernhard|info:eu-repo/dai/nl/6603148005

    2016-01-01

    Technological innovation that is incongruous with established social rules and practices is often confrontedwith strong skepticism and a lack of societal legitimacy. Yet, how the early actors in a new technological field create legitimacy for new products is not well researched. This paper addresses

  14. Self-plagiarism and textual recycling: legitimate forms of research misconduct.

    Science.gov (United States)

    Bruton, Samuel V

    2014-01-01

    The concept of self-plagiarism frequently elicits skepticism and generates confusion in the research ethics literature, and the ethical status of what is often called "textual recycling" is particularly controversial. I argue that, in general, self-plagiarism is unethical because it is deceptive and dishonest. I then distinguish several forms of it and argue against various common rationalizations for textual recycling. I conclude with a discussion of two instances of textual recycling, distinguishing them in terms of their ethical seriousness but concluding that both are ethically problematic.

  15. Beyond Legitimation: A Tribal Response to Maori Education in Aotearoa New Zealand

    Science.gov (United States)

    Jahnke, Huia Tomlins

    2012-01-01

    This article describes an intervention strategy, initiated under the New Zealand Government's tribal partnership scheme, which promotes a culture-based/place-based approach to education in mainstream schools and early childhood centres in one tribal region. Through place-based education children are immersed in local heritage, including language…

  16. A Political Theory of Hegemonic Sustainability: A Legitimate Grand Strategy for America

    Science.gov (United States)

    2013-06-01

    act on perceived interests says nothing important without connecting the kind of interest to the content of the behavior.55 Al Capone and Mother...Air Force Base,, AL 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S...asserting that change is 1 Carl von Clausewitz et al ., On War (Princeton, N.J

  17. Corruption or Guanxi? Differentiating Between the Legitimate, Unethical, and Corrupt Activities of Chinese Government Officials

    OpenAIRE

    Harding, Jacob

    2014-01-01

    China has a well-documented corruption problem that has continued for decades, evolving concurrently with China’s economy and various institutional structures.  In analyzing China’s corruption problem, the current definitions of corruption are inadequate to account for China’s guanxi culture, which requires gift giving in order to facilitate relationship building.  By some definitions, the behaviors that guanxi culture mandates for Chinese society are corrupt when government officials engage ...

  18. Understanding National Trajectories of Regionalism Through Legitimate, Political and Administrative Capital

    DEFF Research Database (Denmark)

    Larsen, Peter Wilgaard; Ferry, Martin

    2015-01-01

    ofunderstanding the dynamics of regionalism, cf. issue 2, is answered by analytically comparing the actors of thevarious regions’ abilities to create institutional elements, collaborating and coordinating policies according tolegitimate, political and administrative capital.Regionalism as a power struggle between...... institutional degrees of regionalism. Thecriteria of the fifth and last institutional degree of regionalism is analysed on regional level to assess whetherregionalism is fully institutionalised.Preliminary results of the analysesEngland merely managed to reach the institutional degree of institutionalisation...... before the RDAs was delegitimisedand replaced by the idea of Local Enterprise Partnerships. Hence, England never managed to reachfull institutionalisation of regionalism.Neither has Poland - due to competition between regional governments and RDAs - managed to reach fullinstitutionalisation...

  19. Human Rights Degradations Related to Natural Law: Philosophical-Juridic Self-Legitimation of Franquism

    Directory of Open Access Journals (Sweden)

    César López Rodríguez

    2017-11-01

    Full Text Available This essay identifies the problematic theoretical nature of human rights under Franco's regime, in the light of either a traditionalist or a totalitarian objective natural right's discursive hegemony. This contradictory theoretical alternative was already present in Ramiro de Maeztu's legal-political doctrine, which as the theoretical seed of the regime, led to those contradictions as embodied in two authors: F. Elías de Tejada and L. Legaz Lacambra. Drawing on a political critique of the text itself, the conclusion evinces the doctrinal state of human rights in the current Spanish constitutional system, exposing its contradictions as derived not from a traditionalist or a totalitarian objective natural right but from a subjective natural right.

  20. Delay In The Issuing Of D-Type Swiss Cartes De Legitimation

    CERN Multimedia

    DSU Department

    2007-01-01

    The Permanent Mission of Switzerland to the International Organisations in Geneva has informed CERN that, for technical reasons, the Federal Department of Foreign Affairs (Département fédéral des Affaires étrangères - DFAE) will be unable to issue D-type cartes de légitimation until after 15 December 2007. This is because, following the introduction of a new graphic design decided by the Swiss Federal Council, stocks of this type of card have run out. In the meantime, the Mission will issue E-type cards to the individuals concerned. These are valid for six months and will be gradually exchanged for D-type cards between December 2007 and February 2008. The Mission points out that the holding of an E-type card for a limited period will have no impact on the status of the officials in question, who will continue to benefit from immunity from jurisdiction in the discharge of their duties and be exempt from the payment of the annual tax on vehicles (a special note to this effect will be sent to the relevant...

  1. Education and Legitimation Crisis: Systemic Tendencies of Capitalism in the Work of Habermas

    Science.gov (United States)

    Crioni, Renato; Gomes, Luiz Roberto; Zuin, Antônio Álvaro Soares

    2015-01-01

    The extensive work of Habermas's intellectual legacy is comparable to the depth and complexity of his reflections. The debates among thinkers close to the conclusions of Adorno and Horkheimer and the mature positions of Habermas are also known. However, despite the marked differences, both of them seem to share a common interpretation: that…

  2. Breaking the wave. The contested legitimation of an alien organizational form

    NARCIS (Netherlands)

    Delmestri, G.; Wezel, F.C.

    2011-01-01

    Organizational forms imbued with values of modernity – that is, rationality, efficiency and equity – diffuse rapidly around the world. Nonetheless, when sustained by beliefs, norms and regulations contrasting with those prevalent in the receiving country, their adoption may be delayed, and

  3. Preconditions for Emergence of Lithuanian Clusters: from Informal Cooperation to Its Legitimation

    Directory of Open Access Journals (Sweden)

    Grumadaitė Kristina

    2017-06-01

    Full Text Available This paper reveals preconditions for the emergence of clusters as self-organisation based industrial systems in a context, in which cooperation traditions are insufficiently developed. These preconditions reflect the principles of the emergence of self-organising complex adaptive systems that are analysed in the complexity theory. Those principles are based on the initiation of non-equilibrium and its purposeful direction into the creation of a new order. This paper highlights the main external and internal tensions that influence informal or formal clustering of enterprises, while various change agents perform different roles making self-organising processes to occur.

  4. Reconsidering Rapport with Urban Teachers: Negotiating Shifting Boundaries and Legitimizing Support

    Science.gov (United States)

    Rinke, Carol R.; Mawhinney, Lynnette

    2014-01-01

    This paper addresses Lincoln's [2010. "'What a long, strange trip it's been …': Twenty-five years of qualitative and new paradigm research." "Qualitative Inquiry" 16, no. 1: 3-9] call for greater attention to the question of rapport in qualitative research through a reflexive examination of researcher-participant relationships…

  5. The regional governance of climate adaptation: a framework for developing legitimate, effective, and resilient governance arrangements

    NARCIS (Netherlands)

    Termeer, C.J.A.M.; Dewulf, A.; Rijswick, H.F.M.W.; Buuren, van A.; Huitema, D.; Meijerink, S.; Rayner, T.; Wiering, M.

    2011-01-01

    Adaptation to climate change raises important governance issues. Notwithstanding the increasing attention on climate adaptation at the global and European level, the variety of local conditions and climate impacts points towards a prime role for regional actors in climate change adaptation. They

  6. The regional governance of climate adaptation : A framework for developing legitimate, effective, and resilient governance arrangements

    NARCIS (Netherlands)

    Termeer, Catrien C. J. A. M.; Dewulf, Art; Van Rijswick, Helena; Van Buuren, Arwin; Huitema, Dave; Meijerink, Sander; Rayner, Tim; Wiering, Mark

    2011-01-01

    Adaptation to climate change raises important governance issues. Notwithstanding the increasing attention on climate adaptation at the global and European level, the variety of local conditions and climate impacts points towards a prime role for regional actors in climate change adaptation. They

  7. Legitimizing Vetoes : A Discourse Analysis of How Vetoes are Motivated in the United Nations Security Council

    OpenAIRE

    Wernersson, Hanna

    2016-01-01

    How is a veto justified? Within the discipline of International Relations, discourse analysis is gaining a higher status. However, there is a surprising lacuna in the literature as a discursive approach to the veto in the United Nations Security Council, is yet to be taken. This is unfortunate, given the Security Council’s prominence. The way in which the council members make meaning through their word choice has profound effects for politics in the international system. There is, nonetheless...

  8. To Win the Game, Know the Rules and Legitimize the Players: Disciplinary Literacy and Multilingual Learners

    Science.gov (United States)

    Hickey, Pamela J.; Lewis, Tarie

    2015-01-01

    Effective disciplinary literacy instruction is an essential element in the education of multilingual learners. In this article, we provide an overview of disciplinary literacy as well as instructional approaches that support meaningful pedagogy for these students. We recognize that multilingual learners are already skilled at negotiating language…

  9. The Legitimization of the Radical Tradition in France, 1789-1901.

    Science.gov (United States)

    Gough, Hugh

    1988-01-01

    Traces the development of radicalism from the 1789 French Revolution to the present. States that radical philosophy has its roots in rationalism and Enlightenment thought and was linked to positivism during the nineteenth century. Despite the failings of radicalism and the Radical Party, the radical tradition set precedents for current political…

  10. Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory

    Science.gov (United States)

    Arbaugh, J. B.; Fornaciari, Charles J.; Hwang, Alvin

    2016-01-01

    Although the volume of business and management education (BME) research has expanded substantially, concerns remain about the field's legitimacy and its ability to attract new and dedicated scholars. An obstacle that may impede field development is lack of knowledge about influential works and authors to frame topical areas of inquiry and future…

  11. Are ‘Agent’ Exclusion Clauses a Legitimate Application of the EU Database Directive?

    Directory of Open Access Journals (Sweden)

    Jimi Groom

    2004-03-01

    Full Text Available This article explores the implications of the implementation of the European Database Directive in the area of autonomous agents and the use of exclusion tools in the part of database owners to stop agents accessing their works.

  12. Are Agent Exclusion Clauses a Legitimate Application of the EU Database Directive?

    OpenAIRE

    Jimi Groom

    2004-01-01

    This article explores the implications of the implementation of the European Database Directive in the area of autonomous agents and the use of exclusion tools in the part of database owners to stop agents accessing their works.

  13. Legitimizing Technical Communication in English Departments: Carolyn Miller's "Humanistic Rationale for Technical Writing"

    Science.gov (United States)

    Moore, Patrick

    2006-01-01

    Carolyn Miller's oft-cited "Humanistic Rationale for Technical Writing," published in 1979, tries to give technical communication faculty more cultural capital in English departments controlled by literature professors. Miller replaces a positivistic emphasis in technical communication pedagogy with rhetoric. She shows how technical knowledge is…

  14. Legitimate Governance of Risk at the EU level? The Case of GMOs

    DEFF Research Database (Denmark)

    Borras, Susana

    2006-01-01

    In the past few years, the EU has been establishing a new regulatory framework for GMOs, a central issue in the governance of risk that came under fierce attack in the mid-1990s. The primary question addressed in this article is whether this new framework will be able to solve the legitimacy...... used in that process; and the forms of participation in the day-to-day governance of risk as envisaged in the new rules. Based on document analysis and a series of interviews with central stakeholders, the conclusions bring up two further theoretical matters regarding EU governance, namely...

  15. Bilingual Rapping in Yucatán, Mexico: Strategic Choices for Maya Language Legitimation and Revitalisation

    Science.gov (United States)

    Cru, Josep

    2017-01-01

    This paper explores the sociolinguistic practices of a group of young bilingual rappers in the Yucatán Peninsula of Mexico. Against the background of ongoing language shift to Spanish in the region, the language choices of a group of Maya youths involved in Hip Hop culture and their agency as policy-makers at the grassroots level is analysed.…

  16. Bizarre marriages: Weddings as a form of legitimization of intimate relations with non-human agents

    Directory of Open Access Journals (Sweden)

    Jan Stasieńko

    2015-10-01

    Full Text Available L’articolo presenta il caso di un matrimonio tra l’utente di una Nintendo DS, Sal9000, e un personaggio del videogame Love Plus, Nene Anegasaki, come esempio della più ampia pratica di far sposare oggetti materiali e immateriali che caratterizza la community Objectum Sexuals. Il testo analizza le forme di intimità e i codici di comunicazione che si creano tra umani e oggetti e presenta pratiche pseudo-legali di matrimonio come manifesti dell’apertura alla relazionità postumana.

  17. Crafting Legitimate Identities: Promotional Strategies in the Ontario Non-Elite Private School Sector

    Science.gov (United States)

    Milian, Roger Pizarro; Quirke, Linda

    2017-01-01

    Conventional wisdom within the sociology of education and organizations posits that schools achieve legitimacy by conforming to institutionalized norms and mimicking the actions of successful peers. Recent work on non-elite private schools (NEPS) shows that this institutional type may serve as an exception to this logic, generally adopting what…

  18. USING THE TUNNEL PENDING ISSUE OR RENEWAL OF SWISS AND/OR FRENCH LEGITIMATION DOCUMENTS

    CERN Multimedia

    Relations with the Host States Service

    2002-01-01

    Members of the CERN personnel, whose: Carte spéciale or Attestation de fonctions issued by the French Ministry of Foreign Affairs and/or Carte de légitimation or Attestation de fonctions issued by the Swiss Federal Department of Foreign Affairs are in the process of being issued or renewed, are authorized to use the Tunnel on condition that they are in possession of: their national identity card (if the Swiss and French regulations so permit) or national passport; their blue CERN card (access card); an attestation drawn up by the Cards Office certifying that the above-mentioned documents are in the process of being issued or in the case of renewal a certified photocopy of the documents, issued by the Users' Office (for Users) or the Cards Office (for all other members of the personnel). Relations with the Host States Service Tel. 72848

  19. A Reciprocal Turn in Criminal Justice? Shifting Conceptions of Legitimate Authority

    NARCIS (Netherlands)

    Jong, F. de

    2013-01-01

    The past decade has seen the rise of a fierce, ongoing controversy concerning the authority of criminal courts and the legitimacy of the criminal justice system as such. This article aims to provide some much needed conceptual clarity regarding the primal subjects under discussion: To what do we

  20. The Legitimation of OECD's Global Educational Governance: Examining PISA and AHELO Test Production

    Science.gov (United States)

    Morgan, Clara; Shahjahan, Riyad A.

    2014-01-01

    Although international student assessments and the role of international organisations (IOs) in governing education via an evidence-based educational policy discourse are of growing interest to educational researchers, few have explored the complex ways in which an IO, such as the OECD, gains considerable influence in governing education during…

  1. The United States, the United Nations, and the Legitimation of the Use of Force

    Science.gov (United States)

    1993-06-01

    rational creature, and not merely sentient . Wight quotes an empiricist, Locke, to justify his use of the word "Rationalist" to describe this tradition...international anarchy, they are fascinated by war. Man is an irrational, fighting animal ; war is a natural and inevitable part of human nature. The Realist...NATO troops, all under a U.N. command modeled on the well-defined and time- tested NATO system, using NATO staff and other resources [Ref. 491. As if on

  2. Il-legitimacy in the eyes of the il-legitimated

    DEFF Research Database (Denmark)

    Gerstroem, Anna

    2013-01-01

    these organizations. The purpose of this paper is to address this gap of knowledge by exploring how members of a bankrupted bank experience and handle attributions of organizational il-legitimacy: to investigate the phenomenon from an inside perspective - in the eyes of the people who undergo it. The paper has...

  3. Producing the Professional Doctorate: The Portfolio as a Legitimate Alternative to the Dissertation

    Science.gov (United States)

    Maxwell, T. W.; Kupczyk-Romanczuk, G.

    2009-01-01

    This paper outlines the potential of the portfolio as a product of doctoral work, especially in the Professional Doctorates. It compares the traditional mode of a single, lengthy but clearly focused doctoral dissertation with the portfolio as a collection of shorter research reports, held together by a linking paper articulating the thesis. We…

  4. Legitimate Peripheral Participation by Sandwich Year Interns in the National Health Service

    Science.gov (United States)

    Davies, Helen Maria; Sandiford, Peter John

    2014-01-01

    Student internships are widely seen as a valuable part of education provision and there is a growing body of research into internship programmes from student, employer and educator perspectives. This paper explores the experiences of a group of information technology interns employed in a small organisation involved in health care business…

  5. The Biome Project: Developing a Legitimate Parallel Curriculum for Physical Education and Life Sciences

    Science.gov (United States)

    Hastie, Peter Andrew

    2013-01-01

    The purpose of this article is to describe the outcomes of a parallel curriculum project between life sciences and physical education. Throughout a 6-week period, students in grades two through five became members of teams that represented different animal species and biomes, and concurrently participated in a season of gymnastics skills and…

  6. From legitimate consumers to public relations pawns: the tobacco industry and young Australians.

    Science.gov (United States)

    Carter, S M

    2003-12-01

    To document the Australian tobacco industry's activities regarding youth smoking to support tobacco control. 492 industry documents from primary and secondary websites were abstracted and analysed. Australian legislation and rhetoric on youth and tobacco has changed dramatically over the last 50 years, from an unproblematic association of teenagers and smoking in the 1960s, through the industry's aggressive attacks and denials in the 1980s, to the 1990s, when industry became newly compliant with "societal expectations" and youth became a dominant bargaining issue in the industry's public relations strategy. The industry's current policy is to simultaneously blame others for underage smoking, frame the industry as socially responsible via voluntary marketing codes, youth access programmes, and school education, and market actively to young adults. The arbitrary distinction between 17 and 18 year olds is, particularly in Australia's dark market, a liability for tobacco control and an opportunity for the industry, which is attempting to claim the high moral ground traditionally occupied by tobacco control on the youth issue. The current review of Australia's Tobacco Advertising Prohibition Act of 1992 should prohibit all forms of industry communication targeting young people, including retail access and schools programmes and below-the-line marketing. Tobacco control advocacy should highlight the industry's attempts to use the youth issue in its own favour while laying the blame elsewhere.

  7. Legitimizing knwoledge of the workplace? Exploring critical perspectives on learning partnerships between universities and corporate organizations

    NARCIS (Netherlands)

    Gustavs, J.; Clegg, S.R.

    2005-01-01

    As a result of changing conditions of funding, emanating in a sense of crisis about viability and the need to find new sources of revenue, many universities in Australia and elsewhere are moving into new areas of application in novel partnerships with corporate organizations, to deliver 'work-based

  8. Empowering communities : A method for the legitimate user-driven specification of network information systems

    NARCIS (Netherlands)

    de Moor, A.

    1999-01-01

    Collaborative work is increasingly being mediated by distributed information technologies such as the Internet. However, it is difficult to make the virtual professional communities, in which this collaboration takes place, operate successfully. One of the reasons is that users are not sufficiently

  9. The legitimate role of advocacy in environmental education: how does it differ from coercion?

    Directory of Open Access Journals (Sweden)

    Karen Cairns

    2002-11-01

    Full Text Available ABSTRACT: This paper examines the controversy in the field of environmental education over the role of advocacy versus presentation of scientific information. The former involves a view of education as process, while the latter perceives education solely as content. Environmental issues involve ethical concerns and value judgments. Scientific information cannot give us the answers to our environmental questions, as these questions have all the inherent complexity of any social issue. Advocacy differs from coercion, bias, and prejudice. Coercion, bias, and prejudice have no place in environmental education, while advocacy for ecological systems does.

  10. Plodnost z hlediska legitimity v regionálním pohledu

    Czech Academy of Sciences Publication Activity Database

    Šalamounová, Petra; Šamanová, Gabriela

    2005-01-01

    Roč. 7, č. 2 (2005), s. 6-9 ISSN 1212-995X R&D Projects: GA AV ČR(CZ) 1QS700280552 Institutional research plan: CEZ:AV0Z70280505 Keywords : fertility * region * marital status Subject RIV: AO - Sociology, Demography

  11. Good legal governance in authoritative public-private partnerships. Conceptualising legitimate partnerships with public authority

    NARCIS (Netherlands)

    Heldeweg, Michiel A.; Sanders, Maurits

    2013-01-01

    The discourse on Public Private Partnerships (PPP) is focused most on Procurement or on what we name ‘Market-PPP’. Placing PPP in the shift from government to governance calls for attention especially to those PPP, which are geared to exercise public legal powers. These ‘Authoritative PPP’ are most

  12. Unraveling High School English Literature Pedagogic Practices: A Legitimation Code Theory Analysis

    Science.gov (United States)

    Jackson, Fiona

    2016-01-01

    Mapping the knowledge formations of language teachers within their pedagogic practices is underresearched, particularly for subject English, a multi-faceted, elusively defined discipline. Deeper knowledge of the pedagogy of subject English teachers is critical, especially within South African education, given the socio-economic power of English in…

  13. The 'humanitarian dimension' of nuclear disarmament: a legitimate debate?

    International Nuclear Information System (INIS)

    Tertrais, Bruno

    2015-01-01

    Since 2010, a debate on the 'humanitarian dimension' of disarmament has been initiated by several governments and non-governmental organisations. It is not unreasonable to measure the potential impact of a major nuclear event on populations and on the biosphere. Yet the grounds for this debate are questionable, and its political conclusions even more so. (author)

  14. Cultures of Violence and Acts of Terror: Applying a Legitimation-Habituation Model to Terrorism

    Science.gov (United States)

    Mullins, Christopher W.; Young, Joseph K.

    2012-01-01

    Although uniquely positioned to provide insight into the nature and dynamics of terrorism, overall the field of criminology has seen few empirically focused analyses of this form of political violence. This article seeks to add to the understanding of terror through an exploration of how general levels of violence within a given society influence…

  15. The difficulties of making 'CPD verifiability' a legitimate measure of learning outcomes.

    Science.gov (United States)

    Kelleher, M

    2012-10-01

    This article offers further thoughts and raises wider issues in the continuing debate over the value of current CPD programmes and the way in which they are measured in terms of input rather than learning outcomes benefiting patients.

  16. PRINCIPIUL SECURITĂŢII JURIDICE ŞI AL ÎNCREDERII LEGITIME

    Directory of Open Access Journals (Sweden)

    Gina Livioara Goga

    2008-05-01

    Full Text Available Le principe de sécurité juridique, tant que le principe de confiance légitime, ont été reconnuspar la jurisprudence du Cour de Justice comme deux principes Fundamentals de l’ordre juridiquecommunautaire.Les motifs pour que ces principes sont tellement invoques dans la jurisprudence communautairepeuvent être justifies par les mêmes considérations pour lesquels les justices nationaux sont plus en plus sensibleaux exigences: l’augmentation des règles et la fréquence corrélatif des ses modifications, comme une preuve del’instabilité du droit.Ces deux principes, bien que différents, sont très relies, en ce sens que le principe de confiance légitimeeste un principe dérive. Le principe est défini par la Cour de Justice comme étant le principe de sécuritéjuridique, en vertu de qui la confiance légitime doit être respecte.

  17. Plea-Bargaining in International Criminal Tribunals: A Legitimate and Necessary Tool

    National Research Council Canada - National Science Library

    Duffin, Matthew

    1999-01-01

    ... 1996.2 The tribunal later tried him for war crimes. The charges facing Erdemovic were not unusual for his crimes, one count of a crime against humanity and an alternative count of a violation of the laws or customs of war...

  18. Legitimizing and Reclaiming Master's Training and Education in Counseling Psychology: An Urgent Concern

    Science.gov (United States)

    Palmer, Laura K.

    2013-01-01

    Jackson and Scheel aptly elucidate the relevance of master's level counselor training programs for counseling psychology doctoral training programs, highlighting key antecedents of the current critical period in our relationship. Counseling psychology has an essential role in the professional lineage of counseling master's programs. Master's…

  19. Rights Legitimate Expectations, Needs and Responsibilities: UNHCR and the New World Order

    OpenAIRE

    GILBERT, GEOFF

    2017-01-01

    This paper starts from the premise that despite the enlarged role that UNHCR has taken on, particularly since 1989, it is still governed by its original 1950 mandate to provide international protection to refugees, as defined. This extended work has led it to deal with non-refugees, even those who are not even internally displaced, and to carrying Out tasks beyond those originally envisaged. Furthermore, its legal personality in international law has increased with its functions, and it is po...

  20. [Health agencies and biomedicine: a new technocratic legitimity and a strategy to share power].

    Science.gov (United States)

    Byk, Christian

    2014-06-01

    The role of health agencies in the field of biomedicine does not appear today anymore as a question of systemic approach but much more as a question of implementing the bioethical principles acknowledged in the legislation and by the different stake-holders of the biomedical techniques.

  1. Rethinking the History of Inclusion of IKS in School Curricula: Endeavoring to Legitimate the Subject

    Science.gov (United States)

    Nhalevilo, Emilia Z. de F. Afonso

    2013-01-01

    Much has been said and written about indigenous knowledge systems (IKS) or, as it is also termed, traditional ecological knowledge. My paper does not intend to discuss how it should be termed, although this is also an important issue as the way we name it frames the possibilities we open for this kind of knowledge. The paper rather looks…

  2. The United States and Yemen: coin in the absence of a legitimate government

    OpenAIRE

    Gillam, Jarrod J. H.; Moran, James E.

    2011-01-01

    The problems Yemen faces today seem insurmountable. The geographic divisions widened by imperialism were cemented by Yemeni President Ali Abdullah Saleh. His heavy-handed suppression of the Houthi rebellion on the border with Saudi Arabia, the Southern secessionist movement, and the Arab Spring protesters delegitimized the regime in the eyes of the Yemeni people. With President Saleh at the helm, water and oil resources were squandered and mismanaged. Al Qaeda in the Arabian Peninsula (AQAP) ...

  3. Legitimating Leadership: The Rhetoric of Succession as a Genre of Presidential Discourse.

    Science.gov (United States)

    Stuckey, Mary

    1992-01-01

    Examines the "rhetoric of succession" as employed by four recent American presidents: Harry Truman, Lyndon Johnson, Gerald Ford, and George Bush. Breaks down their rhetorical strategies while in office into three phases: (1) the early transition (when continuity with previous president is important); (2) middle transition (when new…

  4. Towards a legitimate compromise?: An exploration of Integrated Reporting in the Netherlands

    NARCIS (Netherlands)

    van Bommel, K.

    2014-01-01

    Purpose – The purpose of this paper is to examine the multiplicity of views on integrated reporting and to consider the possibility of, and impediments to, reconciling these multiple rationales (“orders of worth”) and thus gain legitimacy through a compromise. This sheds light on the understanding

  5. [Legitimizing and responsibilities of public health reports: public health reports or social court reports?].

    Science.gov (United States)

    Borgers, D; Streich, W

    1996-11-01

    Since 1970 various initiatives have been taken to improve the information bases of health reporting. However, the efforts made up to now by the Länder, the Federal Government and its corporate bodies are characterised by a lack of experience and shortage of resources; moreover, they are viewed with a critical eye by the public and in the political area. In this contribution the authors describe various topics and delimitations of a health reporting system which go far beyond health statistics and health programmes altogether. The chances of a national health reporting system are based on the assumption that an objective judgement based on expert knowledge and science will be possible and that beyond all particularistic interests, expert knowledge can be organised in a democratic process. Public health reporting varies between two extremes: On the one hand, the current reporting in the media on health-related subjects which is characterised by disagreement among experts, particularistic interests and emotions, and on the other hand the national health reporting, which, on the platform of policy marketing and political image shaping, is suspected of degenerating to a kind of "royal court reporting". A health reporting system based on expert knowledge and characterised by topics with relevance to health policy, expert quality of its information and neutrality to particularistic interests, should go beyond these two extremes. Given the political conditions of budgeting and distribution conflicts, health reporting has to deal with two main aspects: effectiveness and efficiency of employed resources and with the problems of a fair distribution of these resources to provide equal chances in the health sector. What cannot be solved, by questions of procedure, however, is the problem of truth and objective knowledge as well as the problem of confidence. If the general public lacks confidence in national expert knowledge, a society discourse will not lead to political results. Additionally, the argument that medicine is of little importance for health is used to categorically reject a rational investigation of needs and thus to reduce the health system to the status of a modern religious doctrine. Proceeding on the assumption that due to systematic thinking and acting in the field of science, effective medicine symbolises one of the paradigms of progress, then health reporting system can be justified despite the precarious objective knowledge, provided such reporting generates the confidence it deserves thanks to its quality standards and seriousness.

  6. MULTILINGUAL PUBLICATION AS A LEGITIMATE TOOL TO INCREASE ACCESS TO SCIENCE (English translated version

    Directory of Open Access Journals (Sweden)

    Luis Fernando Aragón-Vargas

    2014-12-01

    Full Text Available Duplicate publication, including the submission or publication of the same manuscript in two or more languages, is considered scientific misconduct. Meanwhile, properly conducted multilingual publication has been an exception difficult to deal with, rather than part of the normal scientific publishing process. While publication of a manuscript in a second or third language should not receive the same credit as the original publication, it should not be punished. Provided the appropriate disclosures and preliminary steps are taken, it should be highly encouraged instead, as it will enhance scientific communication and may reduce the knowledge gap around the world. Different types of multilingual publications are summarized and some basic guidelines are offered for the sanctioned publication of the same paper in multiple languages. ALSO AVAILABLE IN SPANISH AND PORTUGUESE FROM THIS JOURNAL.

  7. Legitimizing liberal militarism: politics, law and war in the Arms Trade Treaty

    OpenAIRE

    Stavrianakis, Anna

    2016-01-01

    Post-Cold War efforts to knit together human rights and international humanitarian law in pursuit of tougher arms transfer control reached their apogee in the UN Arms Trade Treaty (ATT). In contrast to dominant accounts based on human security norms, I argue that a key effect of the ATT is to legitimise liberal forms of militarism. During negotiations, the US and UK governments justified their arms export practices in terms of morality, responsibility and legitimacy. And more broadly their ar...

  8. Non traditional legitimation for criminal action - legal protection of goods from other public institutions

    Directory of Open Access Journals (Sweden)

    Franklyn Roger Alves Silva

    2017-03-01

    Full Text Available This article examines the question regards the legitimacy of the prosecution in a supplementary manner from of other public institutions to promote when facing violation of criminal transindividual rights and inertia of the prosecution. When facing crimes with an indeterminate passive subject, there is lack of legal support to base a subsidiary criminal action. Over this perspective, it is investigated if there are other laws allowing an alternative legitimacy for criminal charges. At the same time, it is verified the Public Defender`s Office ability to exercise the supplementary legitimacy.

  9. A Broad Alliance of Civil Society Organizations on Climate Change Mitigation: Political Strength or Legitimizing Support?

    DEFF Research Database (Denmark)

    Nilsen, Heidi; Strømsnes, Kristin; Schmidt, Ulla

    2017-01-01

    Artiklen analyserer kampagnen "Klimavalg 2013", en kampagne i forbindelse med valget til det norske Storting i 2013, hvor mere end 100 civilsamfundsorganisationer gik sammen om seks politiske målsætninger knyttet til bekæmpelse af klimaændringer. Artiklen diskuterer hvordan en kampagne der fik ti...

  10. Farnesol-like endogenous sesquiterpenoids in vertebrates: the probable but overlooked functional "inbrome" anti-aging counterpart of juvenile hormone of insects?

    Directory of Open Access Journals (Sweden)

    Arnold eDe Loof

    2015-01-01

    Full Text Available Literature on the question whether the juvenile stage of vertebrates is hormonally regulated is scarce. It seems to be intuitively assumed that this stage of development is automated, and does not require any specific hormone(s. Such reasoning mimics the state of affairs in insects until it was shown that surgical removal of a tiny pair of glands in the head, the corpora allata, ended larval life and initiated metamorphosis. Decades later, the responsible hormone was found and named juvenile hormone (JH because when present, it makes a larva molt into another larval stage. JH is a simple ester of farnesol, a sesquiterpenoid present in all eukaryotes. Whereas vertebrates do not have an anatomical counterpart of the corpora allata, their tissues do contain farnesol-like sesquiterpenoids (FLS. Some display typical JH activity when tested in appropriate insect bioassays. Some FLS are intermediates in the biosynthetic pathway of cholesterol, a compound that insects and nematodes (= Ecdysozoa cannot synthesize by themselves. They ingest it as a vitamin. Until a recent (2014 reexamination of the basic principle underlying insect metamorphosis, it had been completely overlooked that the Ca2+-pump (SERCA blocker thapsigargin is a sesquiterpenoid that mimics the absence of JH in inducing apoptosis. In our opinion, being in the juvenile state is primarily controlled by endogenous FLS that participate in controlling the activity of Ca2+-ATPases in the sarco(endoplasmic reticulum (SERCAs, not only in insects but in all eukaryotes. Understanding the control mechanisms of being in the juvenile state may boost research not only in developmental biology in general, but also in diseases that develop after the juvenile stage, e.g. Alzheimer’s disease. It may also help to better understand some of the causes of obesity, a syndrome that holometabolous last larval insects severely suffer from, and for which they found a very drastic but efficient solution, namely metamorphosis.

  11. The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells.

    Science.gov (United States)

    Prud'homme, Gérald J; Glinka, Yelena; Kurt, Merve; Liu, Wenjuan; Wang, Qinghua

    2017-12-02

    Systemic gamma-aminobutyric acid (GABA) therapy prevents or ameliorates type 1 diabetes (T1D), by suppressing autoimmune responses and stimulating pancreatic beta cells. In beta cells, it increases insulin secretion, prevents apoptosis, and induces regeneration. It is unclear how GABA mediates these effects. We hypothesized that Klotho is involved. It is a multi-functional protein expressed in the kidneys, brain, pancreatic beta cells, other tissues, and is cell-bound or soluble. Klotho knockout mice display accelerated aging, and in humans Klotho circulating levels decline with age, renal disease and diabetes. Here, we report that GABA markedly increased circulating levels of Klotho in streptozotocin (STZ)-induced diabetes. GABA also increased Klotho in the islet of Langerhans of normal mice, as well as the islets and kidneys of STZ-treated mice. In vitro, GABA stimulated production and secretion of Klotho by human islet cells. Knockdown (KD) of Klotho with siRNA in INS-1E insulinoma cells abrogated the protective effects of GABA against STZ toxicity. Following KD, soluble Klotho reversed the effects of Klotho deficiency. In human islet cells soluble Klotho protected against cell death, and stimulated proliferation and insulin secretion. NF-κB activation triggers beta-cell apoptosis, and both GABA and Klotho suppress this pathway. We found Klotho KD augmented NF-κB p65 expression, and abrogated the ability of GABA to block NF-κB activation. This is the first report that GABAergic stimulation increases Klotho expression. Klotho protected and stimulated beta cells and lack of Klotho (KD) was reversed by soluble Klotho. These findings have important implications for the treatment of T1D. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  12. A novel flexible clinical multiphoton tomograph for early melanoma detection, skin analysis, testing of anti-age products, and in situ nanoparticle tracking

    Science.gov (United States)

    Weinigel, Martin; Breunig, Hans Georg; Gregory, Axel; Fischer, Peter; Kellner-Höfer, Marcel; Bückle, Rainer; König, Karsten

    2010-02-01

    High-resolution 3D microscopy based on multiphoton induced autofluorescence and second harmonic generation have been introduced in 1990. 13 years later, CE-marked clinical multiphoton systems for 3D imaging of human skin with subcellular resolution have first been launched by JenLab company with the tomography DermaInspect®. This year, the second generation of clinical multiphoton tomographs was introduced. The novel multiphoton tomograph MPTflex, equipped with a flexible articulated optical arm, provides an increased flexibility and accessibility especially for clinical and cosmetical examinations. Improved image quality and signal to noise ratio (SNR) are achieved by a very short source-drain spacing, by larger active areas of the detectors and by single photon counting (SPC) technology. Shorter image acquisition time due to improved image quality reduces artifacts and simplifies the operation of the system. The compact folded optical design and the light-weight structure of the optical head eases the handling. Dual channel detectors enable to distinguish between intratissue elastic fibers and collagenous structures simultaneously. Through the use of piezo-driven optics a stack of optical cross-sections (optical sectioning) can be acquired and 3D imaging can be performed. The multiphoton excitation of biomolecules like NAD(P)H, flavins, porphyrins, elastin, and melanin is done by picojoule femtosecond laser pulses from an tunable turn-key femtosescond near infrared laser system. The ability for rapid high-quality image acquisition, the user-friendly operation of the system and the compact and flexible design qualifies this system to be used for melanoma detection, diagnostics of dermatological disorders, cosmetic research and skin aging measurements as well as in situ drug monitoring and animal research.

  13. Anti-aging effects of Piper cambodianum P. Fourn. extract on normal human dermal fibroblast cells and a wound-healing model in mice

    OpenAIRE

    Lee H; Hong Y; Kwon SH; Park J; Park J

    2016-01-01

    Hyunji Lee,1 Youngeun Hong,1 So Hee Kwon,2 Jongsun Park,1 Jisoo Park1 1Department of Pharmacology and Medical Science, Metabolic Diseases and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, 2Department of Pharmacy, College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, South Korea Background: Aging of skin is associated with environmental factors such as ultraviolet rays, a...

  14. The duty to care in an influenza pandemic: a qualitative study of Canadian public perspectives.

    Science.gov (United States)

    Bensimon, Cécile M; Smith, Maxwell J; Pisartchik, Dmitri; Sahni, Sachin; Upshur, Ross E G

    2012-12-01

    Ever since the emergence of SARS, when we were reminded that the nature of health care practitioners' duty to care is greatly contested, it has remained a polarizing issue. Discussions on the nature and limits of health care practitioners' duty to care during disasters and public health emergencies abounds the literature, ripe with arguments seeking to ground its foundations. However, to date there has been little public engagement on this issue. This study involved three Townhall meetings held between February 2008 and May 2010 in three urban settings in Canada in order to probe lay citizens' views about ethical issues related to pandemic influenza, including issues surrounding the duty to care. Participants included Canadian residents aged 18 and over who were fluent in English. Data were collected through day-long facilitated group discussions using case scenarios and focus group guides. Participant's views were organized according to several themes, including the following main themes (and respective sub-themes): 1. Legitimate limits; a) competing obligations; and b) appeal to personal choice; and 2. Legitimate expectations; a) reciprocity; and b) enforcement and planning. Our findings show that participants moved away from categorical notions of the duty to care towards more equivocal and often normative views throughout deliberations. Our analysis contributes a better understanding of the constitutive nature of the duty to care, defined in part by taking account of public views. This broadened understanding can further inform the articulation of acceptable norms of duty to care and policy development efforts. What is more, it illustrates the urgent need for policy-makers and regulators to get clarity on obligations, responsibilities, and accountability in the execution of HCPs' duty to care during times of universal vulnerability. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Download this PDF file

    African Journals Online (AJOL)

    AJTCAM

    The objective of the study was to optimise the LBP extraction technology and to study the anti-aging effect of LBP by establishing D-gal aging mouse model. Orthogonal design was used to study the extraction technology. The experimental aging mouse model was formed by continuous injection of D-gal, and the anti-aging ...

  16. Studies on the anti-radiation activity of ashwagandha

    Energy Technology Data Exchange (ETDEWEB)

    Gandhi, R.; Kaul, B.L. (Regional Research Lab., Jammu (India))

    1984-12-14

    Experiments were carried out to see if root extracts of Withania somnifera (ashwagandha), a reputed anti-ageing drug of 'Ayurveda', gives protection against the simulated ageing effects of ionizing radiations. Strong radioprotective ability was shown by the drug when it was found to be associated with the presence of steroidal lactones in the extract.

  17. Studies on the anti-radiation activity of ashwagandha

    International Nuclear Information System (INIS)

    Gandhi, R.; Kaul, B.L.

    1984-01-01

    Experiments were carried out to see if root extracts of Withania somnifera (ashwagandha), a reputed anti-ageing drug of 'Ayurveda', gives protection against the simulated ageing effects of ionizing radiations. Strong radioprotective ability was shown by the drug when it was found to be associated with the presence of steroidal lactones in the extract. (author)

  18. The development of contemporary chiropractic education in Denmark: an exploratory study

    DEFF Research Database (Denmark)

    Myburgh, Corrie; Mouton, Johan

    2008-01-01

    a local education, to state-subsidized copayments. "Stakeholder behavior," "boundary work," and "countervailing powers" underscore this example of professionalization; and evidence for secondary legitimization appears evident in the third-party influences, peer association legitimacy, and disciplinary...

  19. Reconstruction of the lateral tibia plateau fracture with a third triangular support screw: A biomechanical study

    Directory of Open Access Journals (Sweden)

    Eduardo Moran

    2017-10-01

    Conclusion: Triangular support fixation enhanced interfragmentary stability at the ultimate stage of dynamic loading. However, the level of improvement seems to be limited and may not legitimate the intervention with an additional third screw.

  20. Evaluation of light-emitting diodes (LED) effect on skin biology (in vitro study).

    Science.gov (United States)

    Chabert, R; Fouque, L; Pinacolo, S; Garcia-Gimenez, N; Bonnans, M; Cucumel, K; Domloge, N

    2015-11-01

    Interest in anti-aging approaches has grown significantly in recent years. The most popular are the non invasive methods to decrease the signs of aging. One such method is LED-based therapy. This study investigated the potential of two different wavelengths, 590 nm and 630 nm, combined or not, in the photobiomodulation of proteins involved in the slowdown of the skin aging. These in vitro results on cell viability, cell shape, and mitochondrial function support and build on previous studies suggested that LED treatment is safe. Regarding its biological functions, our data indicated that the combination of two different wavelengths acted in synergy to enhance the impact of each irradiation alone. Combined, the LED wavelengths could improve in vitro the cell shape, the cell proliferation, and the level of major proteins involved in the healing process. These benefits may lead to reinforcement of the skin organization and structure. This hypothesis will be checked in future clinical studies. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Study of Alkylglycerol Containing Shark Liver Oil: a Physico Chemical Support for Biological Effect?

    Directory of Open Access Journals (Sweden)

    Jean-Claude Debouzy

    2008-01-01

    Full Text Available Shark liver oil (SLO, is used in natural medicine as immunity stimulant, cardiovascular protector and anti ageing reagent. These properties were related with the high amounts of alkylglycerols (22% obtained from Greenland shark liver. After a control of the mean SLO composition by NMR and MS, surface and membrane interactions and antioxidant properties were investigated using NMR, ESR and ST measurements and the in vitro consequences on erythrocytes and cells were studied. An estimation of the composition of this extract was performed. Moreover, SLO was found not haemolytic (A concentration inducing 50% haemolysis, HC50 could not be reached and superficial tension measurements revealed slight tension active properties. The 31P and 2H –NMR and ESR studies of phospholipid dispersions (dimyristoyl phosphatidyl cholin, DMPC in the presence of SLO showed a significant increase in membrane fluidity at low temperature (below phase transition temperature predominantly observed at the surface level. The anti oxidant activity was also confirmed, similar as that observed for vitamin E.

  2. Study of Alkylglycerol Containing Shark Liver Oil: a Physico Chemical Support for Biological Effect?

    Directory of Open Access Journals (Sweden)

    Jean-Claude Debouzy

    2008-05-01

    Full Text Available Shark liver oil (SLO, is used in natural medicine as immunity stimulant, cardiovascular protector and anti ageing reagent. These properties were related with the high amounts of alkylglycerols (22% obtained from Greenland shark liver. After a control of the mean SLO composition by NMR and MS, surface and membrane interactions and antioxidant properties were investigated using NMR, ESR and ST measurements and the in vitro consequences on erythrocytes and cells were studied. An estimation of the composition of this extract was performed. Moreover, SLO was found not haemolytic (A concentration inducing 50% haemolysis, HC50 could not be reached and superficial tension measurements revealed slight tension active properties. The 31P and 2H –NMR and ESR studies of phospholipid dispersions (dimyristoyl phosphatidyl cholin, DMPC in the presence of SLO showed a significant increase in membrane fluidity at low temperature (below phase transition temperature predominantly observed at the surface level. The anti oxidant activity was also confirmed, similar as that observed for vitamin E.

  3. Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect?

    Directory of Open Access Journals (Sweden)

    Jean-Claude Debouzy

    2008-01-01

    Full Text Available Shark liver oil (SLO, is used in natural medicine as immunity stimulant, cardiovascular protector and anti ageing reagent. These properties were related with the high amounts of alkylglycerols (22% obtained from Greenland shark liver. After a control of the mean SLO composition by NMR and MS, surface and membrane interactions and antioxidant properties were investigated using NMR, ESR and ST measurements and the in vitro consequences on erythrocytes and cells were studied. An estimation of the composition of this extract was performed. Moreover, SLO was found not haemolytic (A concentration inducing 50% haemolysis, HC 50 could not be reached and superficial tension measurements revealed slight tension active properties. The 31 P and 2 H-NMR and ESR studies of phospholipid dispersions (dimyristoyl phosphatidyl cholin, DMPC in the presence of SLO showed a significant increase in membrane fluidity at low temperature (below phase transition temperature predominantly observed at the surface level. The anti oxidant activity was also confirmed, similar as that observed for vitamin E.

  4. Postinjury malaria: a study of trauma victims in cambodia.

    Science.gov (United States)

    Husum, Hans; Heger, Tove; Sundet, Mads

    2002-02-01

    The pattern of host defense against plasmodium is comparable to the immune response to bacterial infection. Posttraumatic immunosuppression may therefore cause relapses of malaria secondary to trauma and trauma surgery in asymptomatic carriers of the parasites in endemic areas. To our knowledge this has not been validated in epidemiologic studies. Postinjury malaria was registered retrospectively in 342 land mine and war victims from malaria-endemic areas in Cambodia. The incidence rate was analyzed in terms of age, gender, preinjury endemicity, evacuation times, anatomic injury severity, systolic blood pressure at admission, blood transfusion, and duration of the first surgical intervention as independent variables. The rate of postinjury malaria in the study patients was 33.3% (95% CI, 28.3-38.3%). Injury Severity Score (ISS) and surgical operation time were risk factors (area under the curve in receiver operating characteristic plots were 0.73 and 0.79, respectively). The impact of the other risk factors was nonsignificant. Despite difficulties in diagnosing postoperative malaria in endemic areas, the study demonstrates that the rate of postinjury malaria is high. The results legitimate controlled trials of immediate postinjury chemoprophylaxis to severely injured in endemic areas. The authors recommend staged surgical operations with brief primary interventions in victims with severe injuries.

  5. Pilot study dismantlement of 20 lead-lined shipping casks

    International Nuclear Information System (INIS)

    Thurmond, S.M.

    1995-08-01

    This report describes a pilot study conducted at the INEL to dismantle lead-lined casks and shielding devices, separate the radiologically contaminated and hazardous materials, and recycle resultant scrap lead. The facility areas where the work was performed, dismantlement methods, and process equipment are described. Issues and results associated with recycling the lead as a free-released scrap metal are presented and discussed. Data and results from the pilot study are summarized and presented. The study concluded that cask dismantlement at the INEL can be performed as a legitimate recycling activity for scrap lead. Ninety-one percent of the lead recovered passed free-release criteria. The value of the 50,375 lb of recovered lead is approximately $0.45/lb. Resultant waste streams can be satisfactorily treated and disposed. Only very low levels of bulk radiological contamination (47 picocuries/gram of 137 Cs and 3.2 picocuries/gram of 6O Co) were detected in the lead rejected for free release

  6. Personal Values and Moral Disengagement Promote Aggressive and Rule-Breaking Behaviours in Adolescents With Disruptive Behaviour Disorders: A Pilot Study.

    Science.gov (United States)

    Paciello, Marinella; Muratori, Pietro; Ruglioni, Laura; Milone, Annarita; Buonanno, Carlo; Capo, Rosario; Lochman, John E; Barcaccia, Barbara

    2017-01-01

    The pilot study presented in this article investigated the role of moral-cognitive features in understanding aggressive and rule-breaking behaviours in adolescents with Disruptive Behaviour Disorder (DBD). We collected two samples. The community sample was composed of 85 adolescents, whereas the DBD sample was composed of 30 adolescents. Compared with a community sample, adolescents with DBD are more inclined to use moral disengagement (MD) to legitimize their aggressive and rule-breaking behaviours. Moreover, regression models showed that self-enhancement values and MD foster externalizing behaviours taking into account both gender and the group they belonged to, that is, either clinical or community sample. Instead, self-transcendence values could prevent externalizing problems by inhibiting MD. Implications of these findings for assessment and therapeutic interventions are discussed. © The Author(s) 2015.

  7. Use of quantitative methods in the study of cultural goods consumption in popular sectors within the city of Mexicali, B.C.

    Directory of Open Access Journals (Sweden)

    Luz María Ortega Villa

    2007-07-01

    Full Text Available In this work, a brief of the methodology used in the study of cultural goods consumption among popular sector of Mexicali is presented. It includes three phases: a survey (quantitative method, a typology established from a multivariate analysis (data mining, and interviews with selected type-cases (qualitative method all of which are analyzed from a multidimensional perspective whose categories retrieve marketing findings such as consumption visions (Phillips, Olson and Baumgartner, 1995 and conflict resolution strategies (Kwai-Choi and Collins, 2000 applied in the process of decision-making. It also draws from sociology (Thompson, 1990; Bourdieu, 1984 in order to identify reproductive aspects of consumption related to educative capital and social origin, and to deal with symbolic evaluation strategies of legitimate cultural goods.

  8. Relations of power in public schools: a case study

    Directory of Open Access Journals (Sweden)

    Maria Custódia Jorge Rocha

    2014-04-01

    Full Text Available In this paper, based on a few authors who see power as a substantive element – instituted power – and others who consider it as an action verb – instituting power (ROCHA, 2007 –, highlighting some types of power relevant in sociological and organizational research on schools, we present empirical data and institutional discourses, enabled by a case study of qualitative nature. Thus, we can say that relations of power in schools both allow the strengthening of hierarchical and asymmetrical relations of power that exist between institutional players and enable the creation of new “circles of power” that can be promptly activated or can be object of a modernization process held in a more or less generalized manner. This may be reinforced and introduced to players/students, our main target of study, as the most legitimate object, superseding all others but not canceling them. The key objective is to present school organization as a highly complex environment, especially when considered in the light of the multiple and cumulative relations of power that emerge and are materialized.

  9. Review of the study and application on nuclear forensic analysis

    International Nuclear Information System (INIS)

    Liu Cheng'an; Song Jiashu; Wu Jun

    2009-01-01

    For the interests of national security, many scientists who work in the field of nuclear forensic analysis have carried out extensive work in the past on the detection of radioactive material and attributions study, developed a series of scientific and technical means to trace and detect illicit circulation of nuclear materials used to weapons and other radioactive materials which impair public security. All these questions relate to physical, chemical, biological attribution of materials. The nuclear forensic analysis has already become a special, up-to-date sphere of learning. The goal of the study of nuclear forensics is to prevent terrorists from acquiring not only nuclear weapons but also mate- rials that can be used to make such weapons, including radioactive materials for nuclear power plants, and medical radioisotope to and provide us as many clues of environmental links as possible that could help us trace the smuggling path, to answer the following questions: What is the material? Where did it come from? How did it pass from legitimate to illicit use? How did it get to where it was interdicted? Who did it? This paper outlines the contents, analysis means and application of nuclear forensics. (authors)

  10. Race, ideology, and the tea party: a longitudinal study.

    Directory of Open Access Journals (Sweden)

    Eric D Knowles

    Full Text Available The Tea Party movement, which rose to prominence in the United States after the election of President Barack Obama, provides an ideal context in which to examine the roles of racial concerns and ideology in politics. A three-wave longitudinal study tracked changes in White Americans' self-identification with the Tea Party, racial concerns (prejudice and racial identification, and ideologies (libertarianism and social conservatism over nine months. Latent Growth Modeling (LGM was used to evaluate potential causal relationships between Tea Party identification and these factors. Across time points, racial prejudice was indirectly associated with movement identification through Whites' assertions of national decline. Although initial levels of White identity did not predict change in Tea Party identification, initial levels of Tea Party identification predicted increases in White identity over the study period. Across the three assessments, support for the Tea Party fell among libertarians, but rose among social conservatives. Results are discussed in terms of legitimation theories of prejudice, the "racializing" power of political judgments, and the ideological dynamics of the Tea Party.

  11. The Ponzi Scheme: An exploratory study of the victim.

    Directory of Open Access Journals (Sweden)

    Irene Parejo-Pizarro

    2017-02-01

    Full Text Available Objective: The general aim of this study was to explore the victimization process of the so-called “pyramid scheme fraud”. Specifically the causal agents of this fraud and the consequent damage were analyzed as well as the victims’ different responses. Method: The sample comprised 14 victims of the fraud (12 direct victims and 2 indirect victims aged 47-87 years old. Semi-structured interviews were conducted in depth, comprising a total of 36 questions. Results: The factors involved in the fraud appear simultaneously, these factors being economic and trust elements. Considering the reactions to this type of scam, the bipolar factor of earning vs. losing money seems to play a basic role in those victims who decide to invest. This way two different behaviors may emerge: on the one hand, the legitimation of this “business” and, on the other hand, the rejection of it. Conclusions: There were no significant differences between the factors that influence people to invest and maintain their investment in the pyramid scheme fraud. However, some differences have been observed with respect to the reactions against the scam. Future studies should be based on bigger samples, which could lead to the acquisition of a personality profile of the victims. In addition, two subgroups might be considered: Those who make money and those who lose money.

  12. Race, Ideology, and the Tea Party: A Longitudinal Study

    Science.gov (United States)

    Knowles, Eric D.; Lowery, Brian S.; Shulman, Elizabeth P.; Schaumberg, Rebecca L.

    2013-01-01

    The Tea Party movement, which rose to prominence in the United States after the election of President Barack Obama, provides an ideal context in which to examine the roles of racial concerns and ideology in politics. A three-wave longitudinal study tracked changes in White Americans’ self-identification with the Tea Party, racial concerns (prejudice and racial identification), and ideologies (libertarianism and social conservatism) over nine months. Latent Growth Modeling (LGM) was used to evaluate potential causal relationships between Tea Party identification and these factors. Across time points, racial prejudice was indirectly associated with movement identification through Whites’ assertions of national decline. Although initial levels of White identity did not predict change in Tea Party identification, initial levels of Tea Party identification predicted increases in White identity over the study period. Across the three assessments, support for the Tea Party fell among libertarians, but rose among social conservatives. Results are discussed in terms of legitimation theories of prejudice, the “racializing” power of political judgments, and the ideological dynamics of the Tea Party. PMID:23825630

  13. Risk Factors as Major Determinants of Resilience: A Replication Study.

    Science.gov (United States)

    Eshel, Yohanan; Kimhi, Shaul; Lahad, Mooli; Leykin, Dmitry; Goroshit, Marina

    2018-03-16

    The present study was conducted in the context of current concerns about replication in psychological research. It claims that risk factors should be regarded as an integral part of the definition of individual resilience, which should be defined in terms of the balance between individual strength or protective factors, and individual vulnerability or risk factors (IND-SVR). Five independent samples, including 3457 Israeli participants, were employed to determine the effects of resilience promoting and resilience suppressing variables on the IND-SVR index of resilience, and on its two components: recovery from adversity, and distress symptoms. Five path analyses were employed for determining the role of distress symptoms as a measure of psychological resilience, as compared to other indices of this resilience. Results indicated the major role of risk factors (distress symptoms) as an integral component of resilience. This role was generally replicated in the five investigated samples. Risk factors are legitimate, valid, and useful parts of the definition of psychological resilience. Resilience research has shifted away from studying individual risk factors to investigating the process through which individuals overcome the hardships they experience. The present data seem to suggest that this shift should be reexamined.

  14. Study of Active Ingredients in Black Soybean Sprouts and Their Safety in Cosmetic Use

    Directory of Open Access Journals (Sweden)

    Yinmao Dong

    2012-10-01

    Full Text Available Active ingredients in different lengths of black soybean sprouts were extracted with water. Concentrations of the main proteins and polysaccharides were determined by the Forint phenol assay and phenol-sulfuric acid assay, respectively. Anti-oxidizing capacities of the extracts were measured in vitro using the DPPH scavenging test and whitening capacity was measured in vitro using the tyrosinase inhibition test. The effects of the bean sprout extracts on human skin fibroblasts damnified by H2O2 were studied using an MTT colorimetric assay. The safety of the extracts was determined using the red blood cell (RBC test, chick chorioallantoic membrane (CAM assay and human patch test. Results show that DPPH radical scavenging rates at different shoot lengths were all greater than 95%, while the tyrosinase inhibition capacity of the extracts reached 98%. Hemolysis rate in all extracts were lower than 10%, below the 20% regulatory limit for the RBC test. No signs of allergic reactions were observed in the human patch tests. The optimum extract was obtained from bean sprouts grown to 0.5 cm. Extracts of black bean sprouts are safe and can be used as additives in anti-aging and whitening cosmetic products.

  15. Bioactivities in the tamarind seed extracts: A preliminary study

    Science.gov (United States)

    Garg, Sukant; Muangman, Thanchanok; Huifu, He; Ling, Li; Kaul, Sunil C.; Wadhwa, Renu

    2018-01-01

    Stress is a state that triggers change in normal physiology and recognized by human body and brain as an unfavorable event causing concern, worry or anxiety. It may vary from physical, metabolic, physiological or emotional often culminating into wide range of ailments that may range from common cold, decline in functional efficacy of body systems or even cancer. Skin is the largest tissue of the body and makes the first interface with the environment. Skin color and characteristics are highly influenced by environment stress. A variety of natural compounds have been used for anti-stress and disease preventive potentials in worldwide traditional home medicine systems. They have recently attracted attention in research laboratories to dissect their mode of action to promote safe and economic drug development. We have earlier identified anti-stress and anti-aging activities in Withania somnifera, Helicteres angustifolia and honeybee propolis using human cultured normal and cancer cells. In the present study, we explored the effect of tamarind seed extracts prepared in water or 95% ethanol. In cell-based assays, we found that the extracts were safe to use in viable cells (in the range of 0.01-1.0%, for at least 4 weeks). Consistently, molecular studies revealed no effect on the expression/activity of cancer promoting proteins. We recruited oxidative stress models, such as, hydrogen peroxide (H2O2), ultraviolet radiation (UV) and diacylglycerol 1-oleoyl-2-acetyl-sn-glycerol (OAG). Investigation on anti-stress potential of the extracts revealed that they do not offer remarkable protection against stress caused by either H2O2 or UV, however, significantly compromised OAG-induced melanogenesis. The preliminary data warrant further investigations on the active components and mechanism of action to develop useful natural compounds/extracts for manipulation of melanogenesis that plays important role in response of cells to UV and its consequences including DNA damage

  16. CIVIL MOVEMENT IN POLAND – ORIGINS, PROBLEMS, STUDIES

    Directory of Open Access Journals (Sweden)

    Tomasz Pirog

    2008-01-01

    Full Text Available In this paper we present the problem of increasing importance of the citizen and citizeninstitutions in the modern developed societies and different operative areas of the non--governmental organisations. The paper also presents the main Polish centres involved in the studies of the third sector. New issues such as: political-industrial changes (globalisation, social security crisis and the state of prosperity, increase in the individuals’ consciousness of their role in the formation of social order and the crisis of legitimating of democratic institutions led to a broader inclusion of the citizens in the decisive processes. The supported ideas are: subsidising, new public governance and social economy, all of which lead to the best use of the potential in the independent and cooperating subjects. In this movement the new citizen organisations appear and actively participate in the political areas previously led by governmental institutions (ecology, industry, social benefits. Viatheir creativity, and the ability to mobilise the capital embedded in the local communities they contribute to the increasing quality of life and strengthening of the social bonds. However, a strong non-governmental sector does not necessarily mean a strong citizen society, especially when it is governed by the superior regulations.

  17. An ethical framework for cardiac report cards: a qualitative study

    Directory of Open Access Journals (Sweden)

    Rawal Shail

    2005-03-01

    Full Text Available Abstract Background The recent proliferation of health care report cards, especially in cardiac care, has occurred in the absence of an ethical framework to guide in their development and implementation. An ethical framework is a consistent and comprehensive theoretical foundation in ethics, and is formed by integrating ethical theories, relevant literature, and other critical information (such as the views of stakeholders. An ethical framework in the context of cardiac care provides guidance for developing cardiac report cards (CRCs that are relevant and legitimate to all stakeholders. The purpose of this study is to develop an ethical framework for CRCs. Methods Delphi technique – 13 panelists: 2 administrators, 2 cardiac nurses, 5 cardiac patients, 2 cardiologists, 1 member of the media, and 1 outcomes researcher. Panelists' views regarding the ethics of CRCs were analyzed and organized into themes. Results We have organized panelists' views into ten principles that emerged from the data: 1 improving quality of care, 2 informed understanding, 3 public accountability, 4 transparency, 5 equity, 6 access to information 7 quality of information, 8 multi-stakeholder collaboration, 9 legitimacy, and 10 evaluation and continuous quality improvement. Conclusion We have developed a framework to guide the development and dissemination of CRCs. This ethical framework can provide necessary guidance for those generating CRCs and may help them avoid a number of difficult issues associated with existing ones.

  18. Boundary Spanning in Governance Networks: A study about the role of boundary spanners and their effects on democratic throughput legitimacy and performance of governance networks

    NARCIS (Netherlands)

    I.F. van Meerkerk (Ingmar)

    2014-01-01

    markdownabstract__Abstract__ The policy- and decision-making context has changed significantly in the last decades. In the contemporary age of late modernity, the classical modernistic institutions of policyand decision making are increasingly facing difficulties in realizing legitimate and

  19. Tenaga Kerja Indonesia di Malaysia (Studi Kasus TKW Asal Jawa Tengah dengan Pendekatan Fenomenologi

    Directory of Open Access Journals (Sweden)

    Tjipto Subadi

    2010-12-01

    Full Text Available This study aims to examine (1 the main cause of the female workers (FWs in Malaysia from Central Java, Indonesia tortured by their employers, (2 the responsibility of the BP3TKI as an agency sending FWs if there is a problem of the FWs, (3 the steps the Indonesian and Malaysian government take to cope with the case of the Indonesian Labors (ILs tortured by their employers, and (4 the model of cooperation for sending ILs to Malaysia professionally. The study used a phenomenology qualitative approach with a social paradigm definition of micro analysis. The subjects were the FWs in Malaysia tortured by their employers. The data gathering used an observation, documentation and interview method. The data analysis employed a method of first order understanding and second order understanding with an interactive model, including data reduction, data display and conclusion/verification. The findings show that (1 the main cause of torturing against the FWs is a miscommunication, low competency, cultural difference, feudalism behavior, bad institutional structure and difference in Act. (2 The responsibilities of the BP3TKI are legitimate and non-legitimate. (3 The steps the Indonesian government takes are (i providing a guarantee to employers who do not have any problem for employing the Indonesian workers, (ii establishing a Cooperation Agency for Problem Solving, (iii giving one-day or one-week furlough to the FWs, (iv if there is no furlough, an employer will give any compensation to them, (v all the problems of the FWs must be resolved by the Indonesian and Malaysian Cooperation Association, and (vi revising the Memo of Understanding (MoU of the Labor Force. (4 The model of cooperation for sending the WFs to Malaysia is revising and completing the MoU, containing, among others, high wage, furlough, passport holders by (LIs, task force establishment, Labor Force Act, equal-working appointment, a great priority of human values and anti

  20. Obesity, stigma, and responsibility in health care: A synthesis of qualitative studies

    Directory of Open Access Journals (Sweden)

    Kirsti Malterud

    2011-11-01

    Full Text Available Objective: To synthesize research findings on experiences and attitudes about obesity and stigma in health care. Methods: We compiled qualitative studies and applied Noblitt & Hare's meta ethnography to identify, translate, and summarize across studies. Thirteen qualitative studies on experiences and attitudes about obesity and stigma in health care settings were identified and included. Results: The study reveals how stigmatizing attitudes are enacted by health care providers and perceived by patients with obesity. Second-order analysis demonstrated that apparently appropriate advice can be perceived as patronizing by patients with obesity. Furthermore, health care providers indicate that abnormal bodies cannot be incorporated in the medical systems—exclusion of patients with obesity consequently happens. Finally, customary standards for interpersonal respect are legitimately surpassed, and patients with obesity experience contempt as if deserved. Third-order analysis revealed conflicting views between providers and patients with obesity on responsibility, whereas internalized stigma made patients vulnerable for accepting a negative attribution. A theoretical elaboration relates the issues of stigma with those of responsibility. Conclusion: Contradictory views on patients’ responsibility, efforts, knowledge, and motivation merge to internalization of stigma, thereby obstructing healthy coping and collaboration and creating negative contexts for empowerment, self-efficacy, and weight management. Professionals need to develop their awareness for potentially stigmatizing attitudes towards vulnerable patient populations.

  1. An Exploratory Study in Kwazulu-Natal Province

    African Journals Online (AJOL)

    macuser

    stereotypical views. 7. Finally, in an open and accountable democracy citizens are more likely to view the results of any policy reform as legitimate when their opinions have been sought out and when ..... the final helper was an inner-city doctor in Durban, who distributed the survey to Black nurses and nursing assistants.

  2. Determinants of Severity in Acute Pancreatitis: A Nation-wide Multicenter Prospective Cohort Study.

    Science.gov (United States)

    Sternby, Hanna; Bolado, Federico; Canaval-Zuleta, Héctor J; Marra-López, Carlos; Hernando-Alonso, Ana I; Del-Val-Antoñana, Adolfo; García-Rayado, Guillermo; Rivera-Irigoin, Robin; Grau-García, Francisco J; Oms, Lluís; Millastre-Bocos, Judith; Pascual-Moreno, Isabel; Martínez-Ares, David; Rodríguez-Oballe, Juan A; López-Serrano, Antonio; Ruiz-Rebollo, María L; Viejo-Almanzor, Alejandro; González-de-la-Higuera, Belén; Orive-Calzada, Aitor; Gómez-Anta, Ignacio; Pamies-Guilabert, José; Fernández-Gutiérrez-Del-Álamo, Fátima; Iranzo-González-Cruz, Isabel; Pérez-Muñante, Mónica E; Esteba, María D; Pardillos-Tomé, Ana; Zapater, Pedro; de-Madaria, Enrique

    2018-04-18

    The aim of this study was to compare and validate the different classifications of severity in acute pancreatitis (AP) and to investigate which characteristics of the disease are associated with worse outcomes. AP is a heterogeneous disease, ranging from uneventful cases to patients with considerable morbidity and high mortality rates. Severity classifications based on legitimate determinants of severity are important to correctly describe the course of disease. A prospective multicenter cohort study involving patients with AP from 23 hospitals in Spain. The Atlanta Classification (AC), Revised Atlanta Classification (RAC), and Determinant-based Classification (DBC) were compared. Binary logistic multivariate analysis was performed to investigate independent determinants of severity. A total of 1655 patients were included; 70 patients (4.2%) died. RAC and DBC were equally superior to AC for describing the clinical course of AP. Although any kind of organ failure was associated with increased morbidity and mortality, persistent organ failure (POF) was the most significant determinant of severity. All local complications were associated with worse outcomes. Infected pancreatic necrosis correlated with high morbidity, but in the presence of POF, it was not associated to higher mortality when compared with sterile necrotizing pancreatitis. Exacerbation of previous comorbidity was associated with increased morbidity and mortality. The RAC and DBC both signify an advance in the description and differentiation of AP patients. Herein, we describe the complications of the disease independently associated to morbidity and mortality. Our findings are valuable not only when designing future studies on AP but also for the improvement of current classifications.

  3. Educational reform and the public: Two case studies of Poland and Saskatchewan (Canada)

    Science.gov (United States)

    Kaproń, Danuta; Stephan, Werner

    1991-09-01

    The involvement of the public in educational reform processes in modern democratic societies primarily serves the purpose of politically legitimizing the reform agenda. This study examines the rationales implicitly or explicitly submitted to the public to explain why educational reforms in the two countries should be endorsed. Although differences in the political culture caution against a hasty comparison of the two case studies, a number of politico-economic similarities allow for a valid juxtaposition. In Poland the context of socio-political and economic renewal prompted the reformers to emphasize the human-capital model which heightened public awareness and participation in the debate surrounding the reform. Public involvement in Saskatchewan was negatively affected for mainly two reasons. First, the government evidently manipulated public input by various means and thereby appears to have predetermined the outcome. Second, the rationale for the reform, based on a free-market model, tightened the linkage between the needs of the labour market and the mandate of the schools. As a result, public interest and participation was greatly diminished.

  4. Teaching, the Legal Education and Carl Rogers Assumptions: A Case Study in a Private University

    Directory of Open Access Journals (Sweden)

    Leonardo José Peixoto Leal

    2015-12-01

    of examination lawyers and tenders, existing today a new vision called "legal education crisis" in Brazil. According to Carl Rogers (1972, the main role of the teacher is not only to teach but to help the student to learn. This idea has been legitimized internationally since the publication of the UNESCO Report (Delors, 1998, when it pointed out that "learning to know" constitutes one of the pillars of contemporary education. Rogers (1972, in the 1960s,  drew up a list of 10 assumptions implicit deeply rooted among teachers, paradigms that should be addressed by teachers The methodology used was literature and documents with a qualitative approach in the case like an argument from Case Study, considering the Master in Law and the experiences of the Monitoring and Group Study Program. It concludes that the critical evaluation is important in the formation of the legal profession, because the legal education needs to renew itself, from a teaching practice centered learning.

  5. Use of multi-criteria decision analysis in public bidding processes: a case study

    Directory of Open Access Journals (Sweden)

    André Andrade Longaray

    2014-02-01

    Full Text Available Institutions of Higher Education in Brazil (IFES play an important role in the country’s social and scientific development. Focused mainly on teaching, research and extension activities, the IFES are backed by support foundations aimed to the management of financial, human and material resources. Characterized as public bodies, the support foundations are governed by Law no 8.666/93 in what concerns the procurement of goods and services. Therefore, the present study is aimed to develop a model to assist the managers of such foundations in the selection of suppliers to participate in bidding processes that use invitation for bids. Therefore, we conducted a case study in one of the 55 foundations that support Brazilian federal universities. The intervention tool used was the Analytic Hierarchy Process (AHP. Firstly, we established the hierarchy of criteria for problem-solving. Then, a paired comparison was made between criteria for the same level. Subsequently, the consistency analysis of comparison matrices was verified. Finally, the relative priorities of each criterion were obtained and the objective function of the model was constructed. The model was tested through the assessment of the performance of three potential suppliers of IT equipment, and the result was legitimized by decision makers who found the instrument a valid tool to aid in making decisions on supplier selection for the foundation.

  6. A Study on Aging Characteristics of Silicone Oil in HV Oil-filled Cable Termination Based on Infrared Thermal Imaging Test

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    Chen Zhiyong

    2015-01-01

    Full Text Available In order to assess the aging characteristics of Silicone oil in the high voltage oil-filled cable termination after being operated 12 years, the silicone oil in service were studied using the infrared imaging detection, Fourier infrared spectrum analysis, and dielectric properties and micro water content test. The relationship between the infrared thermal imaging temperature and the physical and chemical properties was considered. The results indicate that, the operating temperature of silicone oil within the terminal based on the infrared thermal imaging testing can be characterization of silicone oil aging state. The aging characteristic peak of Silicone oil is P-H key stretching vibration peak, which is near 2360cm− 1, Si-CH3, -CH3 and Si-O-Si keys have no influence of before and after aging. In addition, the aging properties of silicone oil can be reviewed by the change of the dielectric properties, and the decline of the dielectric properties is caused by the aging and water content of materials. The results will be helpful for research of silicone oil aging and optimization design of anti-aging, serving as references for the manufacture, design, and operation.

  7. On the Relevancy of Using Vygotsky's Theoretical Framework to Legitimize Dialogic Teaching/Learning

    Science.gov (United States)

    Petrová, Zuzana

    2013-01-01

    This paper is a response to the growing acceptance that dialogic teaching/learning focusing on the role of intersubjectivity in developing knowledge and reasoning, particularly when this intersubjectivity is mediated and maintained by means of language is an appropriate reaction to the weaknesses of direct instruction within the Vygotskian…

  8. A common basis for facilitated legitimate exchange of biological materials proposed by the European Culture Collections' Organisation

    Directory of Open Access Journals (Sweden)

    Dagmar Fritze

    2009-12-01

    Full Text Available Being charged with the task of accessioning and supplying of living microbiological material, microbial culture collections are institutions that play a central role between the interests of a variety of user communities. On the one side are the providers of living microbiological material, such as individual scientists, institutions and countries of origin and on the other side are the various kinds of recipients/users of cultures of microorganisms from academia and industry. Thus, providing access to high quality biological material and scientific services while at the same time observing donor countries' rights, intellectual property rights, biosafety and biosecurity aspects poses demanding challenges. E.g. donor countries rights relate to Article 15 of the Convention on Biological Diversity: "Contracting parties …. recognize the sovereign rights of states over their natural resources …. shall facilitate access to resources … and not impose restrictions that run counter to the aims of the Convention. Access to natural resources shall be by mutually agreed terms and subject to prior informed consent ..." The use of a proposed standard contract by culture collections is discussed as a way of contractually safeguarding the existing research commons, while observing the new rights established in the Convention on Biological Diversity as well as other existing and new legislation impacting on the accessibility of living microbial material.

  9. Transcending the Myth of Law’s Stifling Technological Innovation : How Adaptive Drug Licensing Processes Are Maintaining Legitimate Regulatory Connections

    NARCIS (Netherlands)

    Dorbeck-Jung, Barbel R.; Brownsword, Roger; Scotford, Eloise; Yeung, Karen

    This chapter explores the lessons that can be drawn from how adaptive drug licensing processes cope with legitimacy issues of regulatory connections. The exploration assumes that a responsive approach to technology regulation offers opportunities to meet legitimacy requirements. Looking at existing

  10. Curriculum Usages as Ideological Discourse and Practice of Power Legitimization in Costa Rica: A Socio-Historical Reflection.

    OpenAIRE

    Campos Hernández, Rodrigo

    2013-01-01

    n this paper we review the sociohistorical role played by the curriculum in Costa Rican society during the nineteenth, twentieth and early decades of the present century, as an ideological tool to disseminate key, develop and consolidate a project exercise of power by the predominant route of consensus and legitimacy. Clearly, the curriculum is closely related to the role that hegemonic groups attribute to education in society, so they can raise the possibility of identifying and trying to cl...

  11. Legal and security requirements for the air transportation of cyanotoxins and toxigenic cyanobacterial cells for legitimate research and analytical purposes.

    Science.gov (United States)

    Metcalf, J S; Meriluoto, J A O; Codd, G A

    2006-05-25

    Cyanotoxins are now recognised by international and national health and environment agencies as significant health hazards. These toxins, and the cells which produce them, are also vulnerable to exploitation for illegitimate purposes. Cyanotoxins are increasingly being subjected to national and international guidelines and regulations governing their production, storage, packaging and transportation. In all of these respects, cyanotoxins are coming under the types of controls imposed on a wide range of chemicals and other biotoxins of microbial, plant and animal origin. These controls apply whether cyanotoxins are supplied on a commercial basis, or stored and transported in non-commercial research collaborations and programmes. Included are requirements concerning the transportation of these toxins as documented by the United Nations, the International Air Transport Association (IATA) and national government regulations. The transportation regulations for "dangerous goods", which by definition include cyanotoxins, cover air mail, air freight, and goods checked in and carried on flights. Substances include those of determined toxicity and others of suspected or undetermined toxicity, covering purified cyanotoxins, cyanotoxin-producing laboratory strains and environmental samples of cyanobacteria. Implications of the regulations for the packaging and air-transport of dangerous goods, as they apply to cyanotoxins and toxigenic cyanobacteria, are discussed.

  12. Krize legitimity Komunistické strany Číny a Chu Ťin-tchaova demokracie

    Czech Academy of Sciences Publication Activity Database

    Klimeš, Ondřej

    XXXIV, č. 3 (2010), s. 27-27 ISSN 0543-7962 Institutional research plan: CEZ:AV0Z90210515 Keywords : Chinese Communist Party * legitimacy crisis * Hu Jintao Subject RIV: AD - Politology ; Political Sciences

  13. What, Who, or Where? Rejoinder to "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory"

    Science.gov (United States)

    Harzing, Anne-Wil

    2016-01-01

    This brief commentary investigates whether article topic, author profile, or journal rank significantly influence an article's citation levels. Anne-Wil Harzing's regression analysis shows that, when all factors are taken into account at the same time, it is "what" is published (topic) and "who" has published it (author) that…

  14. Is regulatory capital a legitimate, comparable and objective global standard? Evidence from 51 institutions across 17 countries

    Directory of Open Access Journals (Sweden)

    Johann Jacobs

    2014-05-01

    Full Text Available Capital as an instrument for financial regulation has come under scrutiny since the financial crisis of 2007 to 2010 highlighted some deficiencies in the ability of capital to absorb unexpected losses and the procyclical nature of capital. This scrutiny arises mainly from the perspective that one of the principal objectives of capital requirements is to promote and contribute to financial stability. However, the literature on the topic is scarce almost to the point of non-existence regarding capital’s validity as tool to level the playing fields between financial institutions. The objective of this article is therefore to investigate financial regulations based on capital requirements from the perspective of its goal of providing equal competitive conditions for financial institutions, the attainment of which is based on the assumption that the cost of capital between institutions (and countries is the same, which might not necessarily be the case. The cost of capital for 51 financial institutions across 17 countries (three institutions per country is accordingly calculated in this article using original weighted average cost of capital and capital asset pricing models, as well as modified versions of these to include more country-specific factors. The objective of the article is sought firstly by determining whether the cost of capital is the same among countries and secondly, based on the results, ascertaining whether financial regulations based on capital requirements can therefore realistically achieve this objective of providing equal competitive conditions for financial institutions.

  15. What Limits of Legitimate Discourse? The Case of Elite Sport as "Thinkable" Official Knowledge in the Norwegian National Curriculum

    Science.gov (United States)

    Kårhus, Svein

    2016-01-01

    In 2006, elite sport was introduced into the Norwegian national curriculum as an elective subject in the pre-tertiary school. Grades achieved in this 5-hours-a-week subject count towards school-leavers' overall attainment grades. Prior to 2006, this subject was only offered as a specially adapted, alternative pedagogy in private schools. The paper…

  16. ON THE EDGE OF ARTIFICIAL LIFE AND EXISTENTIALISM: LEGITIMIZING ‘ROBO-CULTURE’ THROUGH ANARCHY, ORDER AND MANUFACTURE

    Directory of Open Access Journals (Sweden)

    Timuçin Buğra EDMAN

    2017-06-01

    Full Text Available Human beings desire immortality as well as they desire the role of God. Having power and using this power over weak people is one of the oldest behaviors of humankind. One of the most important psychological causes of slave trade, almost as old as human history, is undoubtedly the desire of the human to play the immortal God role. We can see this demand in The Epic of Gilgamesh, Beowulf and The Iliad, which are the earliest written works. We witness the search for the immortality and domination of heroes and anti-heroes in works such as Frankenstein or the Modern Prometheus, I, Robot and The Robots of Dawn in contemporary literary period. In many of these quests, the man's desire for absolute domination and for immortality cause him to confront God with the desire to produce (or create something. On the other hand, in contemporary films such as Batman vs Superman: Dawn of Justice, which is adapted to the motion picture screen, it seems that when the man tries to go beyond himself due to his limitless desire of mastership, he confronts a god, Superman. In the science fiction works of our era, the tendency of man to dominate has begun to turn into chaotic robot-human relationship from old slavery-master relationship like in Asimov’s works. The Terminator or The Matrix series are the best examples for this. Therefore, the article will try to establish the theory of confusion and chaos that people encounter while playing the role of God. In doing so, this theory will be tried to be supported by Asimov's I, Robot, The Robots of Dawn, and Robot Visions novels in the light of some quotations. This article, of course, will also examine the tendency to claim everything in what man thinks he can benefit, rather than simply centering Asimov's works. Are these robots equipped with advanced artificial intelligence going to revolt against the people who produce themselves as Cain rebels against God? Consequently, this work will discuss the point where the relentless search for power and immortality of human beings can reach in view of Asimov's selected novels and definitions.

  17. Brazil builds in Campinas: a symbolic tool of the strategy to legitimate the implementation of the urban-improvement plan

    Directory of Open Access Journals (Sweden)

    Silvia A. Palazzi Zakia

    2010-06-01

    Full Text Available Este artículo trae una reflexión sobre la exposición Brazil Builds que se presentó en Campinas en febrero de 1945. La ciudad era parte del circuito de la exposición que comenzó el 13 de enero de 1943 en el Museum of Modern Art de Nueva York (MoMA. El evento nos lleva a reflexionar sobre cómo se han concertado los distintos intereses involucrados en su realización en esa ciudad. Los esfuerzos del poder público y de sectores de la elite local evidencian una tela de intereses relacionados a la exposición de arquitectura. El objetivo principal es discutir las estructuras de poder locales que se han beneficiado de la dimensión simbólica del arte, usando la exposición como instrumento para legitimar la implantación de un plan de urbanismo para la ciudad (Plan de Mejorías Urbanas, que fue desarrollado por el urbanista Prestes Maia, contratado por la alcadía de la ciudad desde 1934. Ese plan era una parte de un gran proyecto para modernizar la ciudad.

  18. [Scope of the cause of justification of the legitimate exercise of a right in the area of genetic criminality].

    Science.gov (United States)

    Romeo Malanda, Sergio

    2009-01-01

    The Spanish penal Code of 1995 creates various crimes in relation to biotechnology, namely, the offence of genetic manipulation, the offence of cloning and the offence of fertilization of human eggs for purpose others than procreation. These new offences seek to protect new legal interests. But besides these interests, we must not forget that there also exist certain rights of the person that rely on reproductive and genetic technologies to be fully effective. That is why it is inevitable to bring to the discussion other interests of a different nature that may be in conflict with these new legal interests. This is the case in relation to the right to procreate and the right to scientific research. According to Article 20.7 of the Spanish penal Code, a person may justifiably engage in conduct that satisfies the elements of an offence if he has a right to do so. In this work the author analyses if certain conduct that could harm some legal interests, and therefore would be criminally punishable could be justified on the basis of the abovementioned rights to procreate and to undertake scientific research.

  19. [Tensions between the (il)legal and the (il)legitimate in professional health practices regarding women who seek abortion].

    Science.gov (United States)

    López Gómez, Alejandra

    2016-01-01

    The implementation of a pre- and post-abortion health care strategy, adopted in 2004 in Uruguay within a restrictive legal context prior to the decriminalization of abortion in 2012, opened a window of opportunity to link women facing unwanted pregnancies and abortion to health services in order to prevent unsafe abortion practices. This article looks into the tensions generated by the change of focus from maternal-child health to health and sexual and reproductive rights, and how those tensions operate. Using semi-structured interviews and focus groups, the practices and perception and assessment frameworks of professionals in their care of women facing unwanted pregnancy and abortion in the National Integrated Health System in Montevideo are analyzed. The results offer insights into some of the barriers and difficulties that can currently be observed in the implementation of the new law.

  20. Vietnamese Buddhist pagoda in France: “institution-place of memory”. Legitimate power to communicate the memory of exiles

    Directory of Open Access Journals (Sweden)

    Jérôme GIDOIN

    2012-01-01

    Full Text Available Vietnamese Buddhism took hold and developed in France partly because it was able to obtain a monopoly on funeral rites and mourning rites. Many exiled families see the interest of this and delegate their ancestor worship to the monks. By combining the spiritual, socio-cultural, eschatological and political domains, and despite whatever generation gaps may exist, the pagoda allows families to reconstruct a social and family ethic in a context of social acculturation. It provides a fitting answer to the question inherent to the migratory context: how to find new symbolic resources outside of Vietnam? And it can thus implement a communication strategy that officialises, in the land of exile, the inextricable link between the pagoda and the assumption of responsibility for the memory of exiled ancestors.