Three-flavoured neutrino oscillations and the Leggett-Garg inequality

Energy Technology Data Exchange (ETDEWEB)

Gangopadhyay, Debashis; Roy, Animesh Sinha [Ramakrishna Mission Vivekananda University, Department of Physics, Howrah, West Bengal (India)

2017-04-15

Three-flavoured neutrino oscillations are investigated in the light of the Leggett-Garg inequality (LGI). The results obtained are: (a) The maximum violation of the LGI is 2.17036 for neutrino path length L{sub 1} = 140.15 km and ΔL = 1255.7 km. (b) The presence of the mixing angle θ{sub 13} enhances the maximum violation of LGI by 4.6%. (c) The currently known mass hierarchy parameter α = 0.0305 increases the maximum violation of LGI by 3.7%. (d) The presence of a CP-violating phase parameter enhances the maximum violation of LGI by 0.24%, thus providing an alternative indicator of CP violation in three-flavoured neutrino oscillations. The outline of an experimental proposal is suggested whereby the findings of this investigation may be verified. (orig.)

Regional and interspecific variation in Sr, Ca, and Sr/Ca ratios in avian eggshells from the USA.

Science.gov (United States)

Mora, Miguel A; Brattin, Bryan; Baxter, Catherine; Rivers, James W

2011-08-01

To examine regional variation in strontium (Sr), which at high concentrations may reduce eggshell quality, increase egg breakage and reproductive failure, we analyzed Sr, and calcium (Ca) concentrations and Sr/Ca ratios in eggshells from 20 avian species from California, Texas, Idaho, Kansas, and Michigan. In addition, we included data previously reported from Arizona to expand the regional comparisons and to better establish patterns of Sr, and Sr/Ca ratios in bird species across the United States. We found Sr concentrations varied significantly among regions, among species, and among foraging guilds; this variability is strongly influenced by the Sr/Ca ratios in surface water from locations close to the region where the eggshells were collected. Sr concentrations and Sr/Ca ratios were significantly higher in bird eggshells from the Volta wildlife region in the San Joaquin Valley, California and in various locales from Arizona. Sr concentrations and Sr/Ca ratios in bird eggshells from other locations in the USA were lower than those detected in these two regions. Among foraging guilds, invertivores had the highest Sr concentrations and Sr/Ca ratios and carnivores had the lowest. In general, the Sr/Ca ratio increased strongly with increasing Sr concentrations (R(2) = 0.99, P eggshells suggesting that these values could be determined from Sr/Ca ratios in water. Eggshell thickness was poorly correlated with Sr (R(2) = 0.03) but had a significant and positive correlation with Ca and was more properly correlated by a quadratic equation (R(2) = 0.50, Thickness = 2.13 - 0.02Ca - 3.07 * 10(-5)Ca(2)). Our study provides further evidence that Sr accumulates significantly in the avian eggshell, in some regions at concentrations which could be of concern for potential negative effects on reproduction. We suggest that when assessing the effects of metals on avian reproduction in regions with high Sr deposits in rock and soil, Sr concentrations in the eggshell also should be

Can the use of the Leggett-Garg inequality enhance security of the BB84 protocol?

Science.gov (United States)

Shenoy H., Akshata; Aravinda, S.; Srikanth, R.; Home, Dipankar

2017-08-01

Prima facie, there are good reasons to answer in the negative the question posed in the title: the Bennett-Brassard 1984 (BB84) protocol is provably secure subject to the assumption of trusted devices, while the Leggett-Garg-type inequality (LGI) does not seem to be readily adaptable to the device independent (DI) or semi-DI scenario. Nevertheless, interestingly, here we identify a specific device attack, which has been shown to render the standard BB84 protocol completely insecure, but against which our formulated LGI-assisted BB84 protocol (based on an appropriate form of LGI) is secure.

Fulltext PDF

Indian Academy of Sciences (India)

Alexei A Abrikosov, Argonne National Laboratory, Argonne, Illinois, USA,. Vitaly L Ginzburg, P N Lebedev Physical Institute, Moscow, Russia, and. Anthony J Leggett, University of Illinois, Urbana, Illinois, USA. Chemistry - "for discoveries concerning channels in cell membranes" to. Peter Agre, Johns Hopkins University ...

The remarkable occurrence of large rainfall-induced debris flows at two different locations on July 12, 2008, Southern Sierra Nevada, CA, USA

Science.gov (United States)

DeGraff, J.V.; Wagner, D.L.; Gallegos, A.J.; DeRose, M.; Shannon, C.; Ellsworth, T.

2011-01-01

On July 12, 2008, two convective cells about 155 km apart produced a brief period of intense rainfall triggering large debris flows in the southern Sierra Nevada. The northernmost cell was centered over Oak Creek Canyon, an east-flowing drainage, and its tributaries near Independence, CA, USA. About 5:00 P.M., debris flows passed down the South Fork and North Fork of Oak Creek to merge into a large single feature whose passage affected the historic Mt. Whitney Fish hatchery and blocked California State Highway 395. At about the same time, the southernmost cell was largely centered over Erskine Creek, a main tributary of the west-flowing Kern River. Debris flows issued from several branches to coalesce into a large debris flow that passed along Erskine Creek, through the town of Lake Isabella, CA, USA and into the Kern River. It was observed reaching Lake Isabella about 6:30 P.M. Both debris flows caused significant disruption and damage to local communities. ?? 2011 Springer-Verlag.

Selenium Speciation in the Fountain Creek Watershed (Colorado, USA Correlates with Water Hardness, Ca and Mg Levels

Directory of Open Access Journals (Sweden)

James S. Carsella

2017-04-01

Full Text Available The environmental levels of selenium (Se are regulated and strictly enforced by the Environmental Protection Agency (EPA because of the toxicity that Se can exert at high levels. However, speciation plays an important role in the overall toxicity of Se, and only when speciation analysis has been conducted will a detailed understanding of the system be possible. In the following, we carried out the speciation analysis of the creek waters in three of the main tributaries—Upper Fountain Creek, Monument Creek and Lower Fountain Creek—located in the Fountain Creek Watershed (Colorado, USA. There are statistically significant differences between the Se, Ca and Mg, levels in each of the tributaries and seasonal swings in Se, Ca and Mg levels have been observed. There are also statistically significant differences between the Se levels when grouped by Pierre Shale type. These factors are considered when determining the forms of Se present and analyzing their chemistry using the reported thermodynamic relationships considering Ca2+, Mg2+, SeO42−, SeO32− and carbonates. This analysis demonstrated that the correlation between Se and water hardness can be explained in terms of formation of soluble CaSeO4. The speciation analysis demonstrated that for the Fountain Creek waters, the Ca2+ ion may be mainly responsible for the observed correlation with the Se level. Considering that the Mg2+ level is also correlating linearly with the Se levels it is important to recognize that without Mg2+ the Ca2+ would be significantly reduced. The major role of Mg2+ is thus to raise the Ca2+ levels despite the equilibria with carbonate and other anions that would otherwise decrease Ca2+ levels.

Genomic and transcriptomic differences in community acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains.

Science.gov (United States)

Jones, Marcus B; Montgomery, Christopher P; Boyle-Vavra, Susan; Shatzkes, Kenneth; Maybank, Rosslyn; Frank, Bryan C; Peterson, Scott N; Daum, Robert S

2014-12-19

Staphylococcus aureus is a human pathogen responsible for substantial morbidity and mortality through its ability to cause a number of human infections including bacteremia, pneumonia and soft tissue infections. Of great concern is the emergence and dissemination of methicillin-resistant Staphylococcus aureus strains (MRSA) that are resistant to nearly all β-lactams. The emergence of the USA300 MRSA genetic background among community associated S. aureus infections (CA-MRSA) in the USA was followed by the disappearance of USA400 CA-MRSA isolates. To gain a greater understanding of the potential fitness advantages and virulence capacity of S. aureus USA300 clones, we performed whole genome sequencing of 15 USA300 and 4 USA400 clinical isolates. A comparison of representative genomes of the USA300 and USA400 pulsotypes indicates a number of differences in mobile genome elements. We examined the in vitro gene expression profiles by microarray hybridization and the in vivo transcriptomes during lung infection in mice of a USA300 and a USA400 MRSA strain by performing complete genome qRT-PCR analysis. The unique presence and increased expression of 6 exotoxins in USA300 (12- to 600-fold) compared to USA400 may contribute to the increased virulence of USA300 clones. Importantly, we also observed the up-regulation of prophage genes in USA300 (compared with USA400) during mouse lung infection (including genes encoded by both prophages ΦSa2usa and ΦSa3usa), suggesting that these prophages may play an important role in vivo by contributing to the elevated virulence characteristic of the USA300 clone. We observed differences in the genetic content of USA300 and USA400 strains, as well as significant differences of in vitro and in vivo gene expression of mobile elements in a lung pneumonia model. This is the first study to document the global transcription differences between USA300 and USA400 strains during both in vitro and in vivo growth.

Rare-earth metal prices in the USA ca. 1960 to 1994

Science.gov (United States)

Hedrick, James B.

1997-01-01

Rare-earth metal prices were compiled from the late 1950s and early 1960s through 1994. Although commercial demand for rare-earth metals began in 1908, as the alloy mischmetal, commercial quantities of a wide range of individual rare-earth metals were not available until the late 1950s. The discovery of a large, high-grade rare-earth deposit at Mountain Pass. CA, USA, in 1949, was significant because it led to the production of commercial quantities or rare-earth elements that reduced prices and encouraged wider application of the materials. The availability of ore from Mountain Pass, and other large rare-earth deposits, especially those in Australia and China, has provided the world with abundant resources for rare-earth metal production. This availability, coupled with improved technology from Government and private-sector metallurgical research, has resulted in substantial decreases in rare-earth metal prices since the late 1950s and early 1960s. Price series for the individual rare-earth metals (except promethium) are quoted on a kilogram basis from the late 1950s and early 1960s through 1994. Prices are given in US dollars on an actual and constant dollar basis. Industrial and economic factors affecting prices during this time period are examined.

Correction: Ryan, J., et al. Application of the Hyperspectral Imager for the Coastal Ocean to Phytoplankton Ecology Studies in Monterey Bay, CA, USA. Remote Sens. 2014, 6, 1007–1025

Directory of Open Access Journals (Sweden)

Marcos J. Montes

2015-10-01

Full Text Available Studies of phytoplankton ecology in Monterey Bay, CA, USA, using the Hyperspectral Imager for the Coastal Ocean (HICO and other satellite remote sensing and in-situ observations, were presented in [1]. [...

ORIGINAL ARTICLES

African Journals Online (AJOL)

addiction to oxygen, frequent power failures, increasing .... Weitzenblum E. Observance of long-term oxygen therapy at home. Chest 1996; 109: 1135-1136. 3. CaIverly PMA, Leggett Rj, McElderly l, et at Cigarette smoking and secondary.

Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA), USA300 Sequence Type 8 Lineage in Latin-America

Science.gov (United States)

Reyes, Jinnethe; Rincón, Sandra; Díaz, Lorena; Panesso, Diana; Contreras, Germán A.; Zurita, Jeannete; Carrillo, Carlos; Rizzi, Adele; Guzmán, Manuel; Adachi, Javier; Chowdhury, Shahreen; Murray, Barbara E.; Arias, Cesar A.

2009-01-01

Background Methicillin-resistant Staphylococus aureus (MRSA) is an important nosocomial and community-associated (CA) pathogen. Recently, a variant of the MRSA USA300 clone emerged and disseminated in South-America causing important clinical problems. Methods S. aureus isolates were prospectively collected (2006 to 2008) from 32 tertiary hospitals in Colombia, Ecuador, Peru, and Venezuela. MRSA isolates were subjected to antimicrobial susceptibility testing, pulsed field gel electrophoresis (PFGE), and categorized as healthcare-associated (HA)-like or CA-like clones based on genotypic characteristics and detection of genes encoding the Panton-Valentine leukocidin (PVL) and staphylococcal cassette mec (SCCmec) IV. Additionally, MLST of representative isolates of each major CA-MRSA pulsotype, and detection of USA300-associated toxins and the arcA gene were performed in all isolates categorized as CA-MRSA. Results A total of 1570 S. aureus were included; 651 were MRSA (41%), with the highest rates of MRSA isolation in Peru (62%), and lowest in Venezuela (26%) and 71%, 27%, and 2% were classified as HA-like, CA-like, and non-CA/HA-like clones, respectively. Only 9 MRSA isolates were confirmed to have reduced susceptibility to glycopeptides (GISA phenotype). The most common pulsotype (designated ComA) amongst the CA-like MRSA strains was found in 96% of isolates with the majority (81%) having ≤6 bands difference with the USA300-0114 strain. Representative isolates of this clone were ST8 but, unlike the USA300-0114 strain, they harbored a different SCCmec IV subtype and lacked arcA (an indicator of the arginine catabolic mobile element (ACME)). Conclusion A variant CA-MRSA USA300 clone has now become established in South America and, in some countries, is endemic in hospital settings. PMID:19911971

Soil bacterial communities of a calcium-supplemented and a reference watershed at the Hubbard Brook Experimental Forest (HBEF), New Hampshire, USA

Science.gov (United States)

Ganapathi Sridevi; Rakesh Minocha; Swathi A. Turlapati; Katherine C. Goldfarb; Eoin L. Brodie; Louis S. Tisa; Subhash C. Minocha

2012-01-01

Soil Ca depletion because of acidic deposition-related soil chemistry changes has led to the decline of forest productivity and carbon sequestration in the northeastern USA. In 1999, acidic watershed (WS) 1 at the Hubbard Brook Experimental Forest (HBEF), NH, USA was amended with Ca silicate to restore soil Ca pools. In 2006, soil samples were collected from the Ca-...

78 FR 31593 - Notice of Determinations Regarding Eligibility to Apply for Worker Adjustment Assistance

Science.gov (United States)

2013-05-24

... Technologies Rockland, MA........ April 3, 2012 Division. 82,657 Midwest Electric Products, Inc., Mankato, MN........... 82,442 Deluxe Laboratories, Inc., Deluxe Hollywood, CA....... Entertainment Services Group, Inc.. 82,446 Ohio Gravure Technologies, Inc..... Miamisburg, OH...... 82,613 Nestaway LLC, Leggett and Platt...

Comparing conditions for macrorealism: Leggett-Garg inequalities versus no-signaling in time

Science.gov (United States)

Halliwell, J. J.

2017-07-01

We consider two different types of conditions which were proposed to test macrorealism in the context of a system described by a single dichotomic variable Q . This is the view that a macroscopic system evolving in time possesses definite properties which can be determined without disturbing the future or past state. The Leggett-Garg (LG) inequalities, the most commonly studied test, are only necessary conditions for macrorealism, but, building on earlier work J. J. Halliwell, Phys. Rev. A 93, 022123 (2016), 10.1103/PhysRevA.93.022123, it is shown that when the four three-time LG inequalities are augmented with a certain set of two-time inequalities also of the LG form, Fine's theorem applies and these augmented conditions are then both necessary and sufficient. A comparison is carried out with a very different set of necessary and sufficient conditions for macrorealism, namely the no-signaling in time (NSIT) conditions proposed by J. Kofler and C. Brukner, Phys. Rev. A 87, 052115 (2013), 10.1103/PhysRevA.87.052115 and L. Clemente and J. Kofler, Phys. Rev. A 91, 062103 (2015), 10.1103/PhysRevA.91.062103, which ensure that all probabilities for Q at one and two times are independent of whether earlier or intermediate measurements are made in a given run, and do not require (but imply) the LG inequalities. We argue that tests based on the LG inequalities have the form of very weak classicality conditions and can be satisfied in the face of moderate interference effects, but those based on NSIT conditions have the form of much stronger coherence witness conditions, satisfied only for zero interference. The two tests differ in their implementation of noninvasive measurability and so are testing different notions of macrorealism: the augmented LG tests are indirect, entailing a combination of the results of different experiments with only compatible quantities measured in each experimental run, in close analogy with Bell tests, and are primarily tests for macrorealism

Hourly mass and snow energy balance measurements from Mammoth Mountain, CA USA, 2011-2017

Science.gov (United States)

Bair, Edward H.; Davis, Robert E.; Dozier, Jeff

2018-03-01

The mass and energy balance of the snowpack govern its evolution. Direct measurement of these fluxes is essential for modeling the snowpack, yet there are few sites where all the relevant measurements are taken. Mammoth Mountain, CA USA, is home to the Cold Regions Research and Engineering Laboratory and University of California - Santa Barbara Energy Site (CUES), one of five energy balance monitoring sites in the western US. There is a ski patrol study site on Mammoth Mountain, called the Sesame Street Snow Study Plot, with automated snow and meteorological instruments where new snow is hand-weighed to measure its water content. There is also a site at Mammoth Pass with automated precipitation instruments. For this dataset, we present a clean and continuous hourly record of selected measurements from the three sites covering the 2011-2017 water years. Then, we model the snow mass balance at CUES and compare model runs to snow pillow measurements. The 2011-2017 period was marked by exceptional variability in precipitation, even for an area that has high year-to-year variability. The driest year on record, and one of the wettest years, occurred during this time period, making it ideal for studying climatic extremes. This dataset complements a previously published dataset from CUES containing a smaller subset of daily measurements. In addition to the hand-weighed SWE, novel measurements include hourly broadband snow albedo corrected for terrain and other measurement biases. This dataset is available with a digital object identifier: https://doi.org/10.21424/R4159Q.

A population-based study examining the emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 in New York City

Directory of Open Access Journals (Sweden)

Panwar Monica

2006-11-01

Full Text Available Abstract Background Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA is a serious pathogen in several regions in the United States. It is unclear which populations are at high risk for the emergence of these strains. Methods All unique patient isolates of S. aureus were collected from hospitals in Brooklyn, NY over a three-month period. Isolates of MRSA that were susceptible to clindamycin underwent SCCmec typing. Isolates with the SCCmec type IV (characteristic of CA-MRSA strains underwent ribotyping. Demographic information involving the neighborhoods of Brooklyn was also gathered and correlated with the prevalence of CA-MRSA strains. Results Of 1316 isolates collected during the surveillance, 217 were MRSA susceptible to clindamycin. A total of 125 isolates possessed SCCmec type IV; 72 belonged to the USA300 strain and five belonged to the USA400 strain. Hospitals in the eastern part of the city had the highest prevalence of USA300 strain. Individuals in the eastern region, when compared to the western region, were more likely to be Black, Hispanic, female, and Conclusion The USA300 strain of CA-MRSA is emerging in New York City. In this population-based study, urban regions of lower socioeconomic status and with evidence of overcrowding appear to be at higher risk for the emergence of this pathogen.

Application of the Hyperspectral Imager for the Coastal Ocean to Phytoplankton Ecology Studies in Monterey Bay, CA, USA

Directory of Open Access Journals (Sweden)

John P. Ryan

2014-01-01

Full Text Available As a demonstrator for technologies for the next generation of ocean color sensors, the Hyperspectral Imager for the Coastal Ocean (HICO provides enhanced spatial and spectral resolution that is required to understand optically complex aquatic environments. In this study we apply HICO, along with satellite remote sensing and in situ observations, to studies of phytoplankton ecology in a dynamic coastal upwelling environment—Monterey Bay, CA, USA. From a spring 2011 study, we examine HICO-detected spatial patterns in phytoplankton optical properties along an environmental gradient defined by upwelling flow patterns and along a temporal gradient of upwelling intensification. From a fall 2011 study, we use HICO’s enhanced spatial and spectral resolution to distinguish a small-scale “red tide” bloom, and we examine bloom expansion and its supporting processes using other remote sensing and in situ data. From a spectacular HICO image of the Monterey Bay region acquired during fall of 2012, we present a suite of algorithm results for characterization of phytoplankton, and we examine the strengths, limitations, and distinctions of each algorithm in the context of the enhanced spatial and spectral resolution.

Self-excited current oscillations in a resonant tunneling diode described by a model based on the Caldeira–Leggett Hamiltonian

International Nuclear Information System (INIS)

Sakurai, Atsunori; Tanimura, Yoshitaka

2014-01-01

The quantum dissipative dynamics of a tunneling process through double barrier structures is investigated on the basis of non-perturbative and non-Markovian treatment. We employ a Caldeira–Leggett Hamiltonian with an effective potential calculated self-consistently, accounting for the electron distribution. With this Hamiltonian, we use the reduced hierarchy equations of motion in the Wigner space representation to study non-Markovian and non-perturbative thermal effects at finite temperature in a rigorous manner. We study current variation in time and the current–voltage (I–V ) relation of the resonant tunneling diode for several widths of the contact region, which consists of doped GaAs. Hysteresis and both single and double plateau-like behavior are observed in the negative differential resistance (NDR) region. While all of the current oscillations decay in time in the NDR region in the case of a strong system–bath coupling, there exist self-excited high-frequency current oscillations in some parts of the plateau in the NDR region in the case of weak coupling. We find that the effective potential in the oscillating case possesses a basin-like form on the emitter side (emitter basin) and that the current oscillation results from tunneling between the emitter basin and the quantum well in the barriers. We find two distinct types of current oscillations, with large and small oscillation amplitudes, respectively. These two types of oscillation appear differently in the Wigner space, with one exhibiting tornado-like motion and the other exhibiting a two piston engine-like motion. (paper)

Spectral Irradiance Calibration in the Infrared. XVI. Improved Accuracy in the Infrared Spectra of the Secondary and Tertiary Standard Calibration Stars

Science.gov (United States)

2006-10-01

resolution ( AlA ). -, 400) spectroscopy obtained on infrared standard stars by the Short Wavelength Spectrometer on the Infrared Space Observatory with high...1995): 2.1-2.4 pm Strecker et al. (1979): 1.22-2.4 pm 6 See http://vizier.hia.nrc.ca/viz-bin/VizieR. REFERENCES Alonso, A., Salaris, M., Arribas , S...Haddock, D. J., Arribas , S., Leggett, S. K., & Mountain, C. M. 1988, A&AS, 74, 127

Nitrogen, phosphorus, potassium, calcium, magnesium, and zinc in southeastern USA harvested flax

Science.gov (United States)

Flax (Linum usitatissimum L.) is a winter crop in the Southeast USA that has potential in double cropping systems. This research was conducted to provide estimates of nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg), and zinc (Zn) removal in the harvested portions of the cro...

Elevation dependent sensitivity of northern hardwoods to Ca addition at Hubbard Brook Experimental Forest, NH USA

Science.gov (United States)

Rakesh Minocha; Stephanie Long; Palaniswamy Thangavel; Subhash C. Minocha; Christopher Eagar; Charles T. Driscoll

2010-01-01

Acidic deposition has caused a depletion of calcium (Ca) in the northeastern forest soils. Wollastonite (Ca silicate) was added to watershed 1 (WS1) at the Hubbard Brook Experimental Forest (HBEF) in 1999 to evaluate its effects on various functions of the HBEF ecosystem. The effects of Ca addition on foliar soluble (extractable in 5% HClO4) ions...

Reservoir Changes Derived from Seismic Observations at The Geysers Geothermal Field, CA, USA

Science.gov (United States)

Gritto, R.; Jarpre, S.

2012-04-01

Induced seismicity associated with the exploitation of geothermal fields is used as a tool to characterize and delineate changes associated with injection and production of fluids from the reservoir. At the same time public concern of felt seismicity has led to objections against the operation of geothermal reservoirs in close proximity to population centers. Production at the EGS sites in Basel (Switzerland) was stopped after renewed seismicity caused concern and objection from the public in the city. Operations in other geothermal reservoirs had to be scaled back or interrupted due to an unexpected increase in seismicity (Soultz-sous-forêt, France, Berlín, El Salvador). As a consequence of these concerns and in order to optimize the use of induced seismicity for reservoir engineering purposes, it becomes imperative to understand the relationship between seismic events and stress changes in the reservoir. We will address seismicity trends at The Geysers Geothermal Reservoir, CA USA, to understand the role of historical seismicity associated with past injection of water and/or production of steam. Our analysis makes use of a comprehensive database of earthquakes and associated phase arrivals from 2004 to 2011. A high-precision sub-set of the earthquake data was selected to analyze temporal changes in seismic velocities and Vp/Vs-ratio throughout the whole reservoir. We find relatively low Vp/Vs values in 2004 suggestive of a vapor dominated reservoir. With passing time, however, the observed temporal increase in Vp/Vs, coupled with a decrease in P- and S-wave velocities suggests the presence of fluid-filled fractured rock. Considering the start of a continuous water injection project in 2004, it can be concluded that the fluid saturation of the reservoir has successfully recovered. Preliminary results of 3-D velocity inversions of seismic data appear to corroborate earlier findings that the lowest Vp/Vs estimates are observed in the center of the reservoir

Parallel Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus USA300 Infection in North and South America.

Science.gov (United States)

Planet, Paul J; Diaz, Lorena; Kolokotronis, Sergios-Orestis; Narechania, Apurva; Reyes, Jinnethe; Xing, Galen; Rincon, Sandra; Smith, Hannah; Panesso, Diana; Ryan, Chanelle; Smith, Dylan P; Guzman, Manuel; Zurita, Jeannete; Sebra, Robert; Deikus, Gintaras; Nolan, Rathel L; Tenover, Fred C; Weinstock, George M; Robinson, D Ashley; Arias, Cesar A

2015-12-15

The community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) epidemic in the United States is attributed to the spread of the USA300 clone. An epidemic of CA-MRSA closely related to USA300 has occurred in northern South America (USA300 Latin-American variant, USA300-LV). Using phylogenomic analysis, we aimed to understand the relationships between these 2 epidemics. We sequenced the genomes of 51 MRSA clinical isolates collected between 1999 and 2012 from the United States, Colombia, Venezuela, and Ecuador. Phylogenetic analysis was used to infer the relationships and times since the divergence of the major clades. Phylogenetic analyses revealed 2 dominant clades that segregated by geographical region, had a putative common ancestor in 1975, and originated in 1989, in North America, and in 1985, in South America. Emergence of these parallel epidemics coincides with the independent acquisition of the arginine catabolic mobile element (ACME) in North American isolates and a novel copper and mercury resistance (COMER) mobile element in South American isolates. Our results reveal the existence of 2 parallel USA300 epidemics that shared a recent common ancestor. The simultaneous rapid dissemination of these 2 epidemic clades suggests the presence of shared, potentially convergent adaptations that enhance fitness and ability to spread. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Faithful test of nonlocal realism with entangled coherent states

International Nuclear Information System (INIS)

Lee, Chang-Woo; Jeong, Hyunseok; Paternostro, Mauro

2011-01-01

We investigate the violation of Leggett's inequality for nonlocal realism using entangled coherent states and various types of local measurements. We prove mathematically the relation between the violation of the Clauser-Horne-Shimony-Holt form of Bell's inequality and Leggett's one when tested by the same resources. For Leggett inequalities, we generalize the nonlocal realistic bound to systems in Hilbert spaces larger than bidimensional ones and introduce an optimization technique that allows one to achieve larger degrees of violation by adjusting the local measurement settings. Our work describes the steps that should be performed to produce a self-consistent generalization of Leggett's original arguments to continuous-variable states.

USA

DEFF Research Database (Denmark)

Nedergaard, Peter

http://www.systime.dk/ungdomsuddannelser/almen-studieforberedelse/usa-en-grundbog-i-politik-og-okonomi.html......http://www.systime.dk/ungdomsuddannelser/almen-studieforberedelse/usa-en-grundbog-i-politik-og-okonomi.html...

The Mayak Worker Dosimetry System (MWDS-2013): a comparison of intakes based on urine versus autopsy data from Mayak workers using the Leggett systemic model for plutonium

International Nuclear Information System (INIS)

Birchall, A.; Dorrian, M.-D.; Suslova, K. G.; Sokolova, A. B.

2017-01-01

The Mayak Worker Dosimetry System-2013 (MWDS-2013) uses a model developed by Leggett and colleagues to represent the biokinetic behaviour of plutonium after uptake to blood. Of particular importance, with regard to estimating intakes (and doses), is the distribution of activity between urine and body organs (particularly liver and skeleton). In this study, measurement data (urine and autopsy) from around 500 Mayak workers have been used to validate use of this model. A robust method has been developed and used to estimate intakes from both urine and autopsy data separately, and the ratio of these estimates has been calculated for each worker. The geometric mean ratio has been shown to lie within a range of 0.92-1.14, depending on assumptions made. Since this range includes 1, the hypothesis that the model is unbiased with regard to estimating intakes either with urine or autopsy data cannot be rejected on the basis of these data. This lends weight to the argument for increasing the MWDS-2013 cohort to include an additional 500 workers for whom only autopsy data are available, and who have previously been excluded from the cohort. Future directions in which this work could be extended are also suggested. (authors)

Asia prostate cancer study (A-CaP Study launch symposium

Directory of Open Access Journals (Sweden)

Hideyuki Akaza

2016-09-01

Full Text Available The Asian Prostate Cancer (A-CaP Study is an Asia-wide initiative that has been developed over the course of 2 years. The A-CaP Study is scheduled to begin in 2016, when each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognosis investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea. The inaugural Board Meeting of A-CaP was held on December 11, 2015 at the Research Center for Advanced Science and Technology, The University of Tokyo, attended by representatives of all participating countries and regions, who signed a memorandum of understanding concerning registration for A-CaP. Following the Board Meeting an A-CaP Launch Symposium was held. The symposium was attended by representatives of countries and regions participating in A-CaP, who gave presentations. Presentations and a keynote address were also delivered by representatives of the University of California San Francisco, USA, and the Peter MacCallum Cancer Centre, Australia, who provided insight and experience on similar databases compiled in their respective countries.

Sedimentary organic biomarkers suggest detrimental effects of PAHs on estuarine microbial biomass during the 20th century in San Francisco Bay, CA, USA

Science.gov (United States)

Nilsen, Elena B.; Rosenbauer, Robert J.; Fuller, Christopher C.; Jaffe, Bruce E.

2014-01-01

Hydrocarbon contaminants are ubiquitous in urban aquatic ecosystems, and the ability of some microbial strains to degrade certain polycyclic aromatic hydrocarbons (PAHs) is well established. However, detrimental effects of petroleum hydrocarbon contamination on nondegrader microbial populations and photosynthetic organisms have not often been considered. In the current study, fatty acid methyl ester (FAME) biomarkers in the sediment record were used to assess historical impacts of petroleum contamination on microbial and/or algal biomass in South San Francisco Bay, CA, USA. Profiles of saturated, branched, and monounsaturated fatty acids had similar concentrations and patterns downcore. Total PAHs in a sediment core were on average greater than 20× higher above ∼200 cm than below, which corresponds roughly to the year 1900. Isomer ratios were consistent with a predominant petroleum combustion source for PAHs. Several individual PAHs exceeded sediment quality screening values. Negative correlations between petroleum contaminants and microbial and algal biomarkers – along with high trans/cis ratios of unsaturated FA, and principle component analysis of the PAH and fatty acid records – suggest a negative impacts of petroleum contamination, appearing early in the 20th century, on microbial and/or algal ecology at the site.

Tšarterkool USA-s / Johannes Kiersch

Index Scriptorium Estoniae

Kiersch, Johannes

2001-01-01

24.-27. mainì 01 toimub Tallinnas EFFE 2001 (European Forum of Freedom in Education) konverents "Haridus tänases kodanikuühiskonnas." Konverentsil esineb ka Witteni Waldorf-pedagoogika Instituudi õppejõud Johannes Kiersch. Lähemalt tema artiklist USA-s populaarsust võitvate tsharterkoolide kohta, mis on riigi- ja erakooli vahevorm

77 FR 18848 - Accreditation and Approval of Intertek USA, Inc., as a Commercial Gauger and Laboratory

Science.gov (United States)

2012-03-28

... Intertek USA, Inc., as a Commercial Gauger and Laboratory AGENCY: U.S. Customs and Border Protection... commercial gauger and laboratory. SUMMARY: Notice is hereby given that, pursuant to 19 CFR 151.12 and 19 CFR 151.13, Intertek Caleb Brett, 6050 Egret Court, Benicia, CA 94510, has been approved to gauge and...

Strontium-90 migration in Hanford sediments, USA

International Nuclear Information System (INIS)

Steefel, C.I.; Yang, L.; Carroll, S.A.; Roberts, S.; Zachara, J.M.; Yabusaki, S.B.

2005-01-01

Full text of publication follows: Strontium-90 is an important risk-driving contaminant at the Hanford site in eastern Washington, USA. Disposal operations at the Hanford 100-N area released millions of liters of reactor cooling water containing high concentrations of strontium-90 into the vadose zone immediately adjacent to the Columbia River. The effectiveness of pump-and-treat methods for remediation have been questioned, largely because the strontium is strongly sorbed on subsurface sediments via ion exchange reactions and co-precipitation in carbonates. In addition, groundwater monitoring wells show a fluctuating seasonal behavior in which high strontium-90 concentrations correlate with high Columbia River stage, even while average concentrations remain approximately constant. A series of fully saturated reactive transport column experiments have been conducted to investigate the important controls on strontium migration in Hanford groundwater [1]. The experiments were designed to investigate the multicomponent cation exchange behavior of strontium in competition with the cations Na + , Ca +2 , and Mg +2 , the concentration of which differs between river water and groundwater. Reactive transport modeling of the experiments indicates that the Sr +2 selectivity coefficient becomes larger with increasing NaNO 3 concentration, a behavior also shown by the divalent cations Ca +2 and Mg +2 . A new set of column experiments investigates the effect of wetting and drying cycles on strontium- 90 sorption and migration by considering episodic flow in Hanford sediments. In addition, the effect of fluctuating aquifer chemistry as a result of changes in the Columbia River stage on Sr +2 sorption is addressed. Modeling of multicomponent reactive transport under variably saturated conditions is used to interpret the results of the episodic flow/chemistry experiments. [1] Experimental and modeling studies of the migration behavior of strontium in Hanford sediments, USA. C

Effects of inhaled anesthetic isoflurane on long-term potentiation of CA3 pyramidal cell afferents in vivo

Directory of Open Access Journals (Sweden)

Ballesteros KA

2012-11-01

Full Text Available Kristen A Ballesteros,1 Angela Sikorski,2 James E Orfila,3 Joe L Martinez Jr41Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA; 2Texas A&M University Texarkana, Texarkana, TX, USA; 3University of Colorado in Denver, Denver, CO, USA; 4University of Illinois in Chicago, Chicago, IL, USAAbstract: Isoflurane is a preferred anesthetic, due to its properties that allow a precise concentration to be delivered continually during in vivo experimentation. The major mechanism of action of isoflurane is modulation of the γ-amino butyric acid (GABAA receptor-chloride channel, mediating inhibitory synaptic transmission. Animal studies have shown that isoflurane does not cause cell death, but it does inhibit cell growth and causes long-term hippocampal learning deficits. As there are no studies characterizing the effects of isoflurane on electrophysiological aspects of long-term potentiation (LTP in the hippocampus, it is important to determine whether isoflurane alters the characteristic responses of hippocampal afferents to cornu ammonis region 3 (CA3. We investigated the effects of isoflurane on adult male rats during in vivo induction of LTP, using the mossy fiber pathway, the lateral perforant pathway, the medial perforant pathway, and the commissural CA3 (cCA3 to CA3, with intracranial administration of Ringer’s solution, naloxone, RS-aminoindan-1, 5-dicarboxylic acid (AIDA, or 3-[(R-2-carboxypiperazin-4-yl]-propo-2-enyl-1-phosphonic acid (CPP. Then, we compared these responses to published electrophysiological data, using sodium pentobarbital as an anesthetic, under similar experimental conditions. Our results showed that LTP was exhibited in animals anesthetized with isoflurane under vehicle conditions. With the exception of AIDA in the lateral perforant pathway, the defining characteristics of the four pathways appeared to remain intact, except for the observation that LTP was markedly reduced in animals

Signatures of cytoplasmic proteins in the exoproteome distinguish community- and hospital-associated methicillin-resistant Staphylococcus aureus USA300 lineages

DEFF Research Database (Denmark)

Mekonnen, Solomon A.; Palma Medina, Laura M.; Glasner, Corinna

2017-01-01

Methicillin-resistant Staphylococcus aureus (MRSA) is the common name for a heterogeneous group of highly drug-resistant staphylococci. Two major MRSA classes are distinguished based on epidemiology, namely community-associated (CA) and hospital-associated (HA) MRSA. Notably, the distinction of CA......- and HA-MRSA based on molecular traits remains difficult due to the high genomic plasticity of S. aureus. Here we sought to pinpoint global distinguishing features of CA- and HA-MRSA through a comparative genome and proteome analysis of the notorious MRSA lineage USA300. We show for the first time that CA......- and HA-MRSA isolates can be distinguished by 2 distinct extracellular protein abundance clusters that are predictive not only for epidemiologic behavior, but also for their growth and survival within epithelial cells. This ‘exoproteome profiling’ also groups more distantly related HA-MRSA isolates...

Recognizing loss of open forest ecosystems by tree densification and land use intensification in the Midwestern USA

Science.gov (United States)

Brice B. Hanberry; Marc D. Abrams

2018-01-01

Forests and grasslands have changed during the past 200 years in the eastern USA, and it is now possible to quantify loss and conversion of vegetation cover at regional scales. We quantified historical (ca. 1786-1908) and current land cover and determined long-term ecosystem change to either land use or closed forests in eight states of the Great Lakes and Midwest....

LHV soovib USA-s kohtuvälist kokkulepet / Toivo Tänavsuu

Index Scriptorium Estoniae

Tänavsuu, Toivo

2005-01-01

Kohtuväline kokkulepe LHV ja USA väärtpaberituru järelevalveasutuse SEC vahel tähendaks külmutatud väärtpaberikontode avamist, ent tõenäoliselt ka seda, et LHV peab maksma trahvi. Kohtuistungil USA-s esindavad LHV töötajaid Kristjan Lepikut ja Oliver Peeki advokaadid. Lisa: Teisedki on "sundpuhkusel"

Euroopa teadis USA salavanglaist / Tõnis Erilaid

Index Scriptorium Estoniae

Erilaid, Tõnis, 1943-

2005-01-01

USA endise välisministri Colin Powelli sõnul pole see tema sõpradele Euroopas uudiseks, et USA on viinud vange riikidesse, kus tema seadused ei kehti. USA praeguse välisministri Condoleezza Rice'i sõnul on USA vange üle kuulanud väljaspool USA-d. USA Today kirjeldab Stare Kiejkuty küla Poolas, kus arvatavasti on olnud salavangla

Guantanamo rikub USA seadusi / Krister Paris

Index Scriptorium Estoniae

Paris, Krister, 1977-

2003-01-01

Kaks USA tsiviilkohut leiavad oma otsuses, et USA valitsus rikub USA-s ja Guantanamo sõjaväebaasis kinnipeetavate nn. vaenlasvõitlejate õigusi. Inimõigusorganisatsioonid avaldavad heameelt kohtute otsuste üle

Multi-species coral Sr/Ca-based sea-surface temperature reconstruction using Orbicella faveolata and Siderastrea siderea from the Florida Straits

Science.gov (United States)

Flannery, Jennifer A.; Richey, Julie N.; Thirumalai, Kaustubh; Poore, Richard Z.; DeLong, Kristine L.

2017-01-01

We present new, monthly-resolved Sr/Ca-based sea-surface temperature (SST) records from two species of massive coral, Orbicella faveolata and Siderastrea siderea, from the Dry Tortugas National Park, FL, USA (DTNP). We combine these new records with published data from three additional S. siderea coral colonies to generate a 278-year long multi-species stacked Sr/Ca-SST record from DTNP. The composite record of mean annual Sr/Ca-SST at DTNP shows pronounced decadal-scale variability with a range of 1 to 2°C. Notable cool intervals in the Sr/Ca-derived SST lasting about a decade centered at ~1845, ~1935, and ~1965 are associated with reduced summer Sr/Ca-SST (monthly maxima < 29°C), and imply a reduction in the spatial extent of the Atlantic Warm Pool (AWP). There is significant coherence between the composite DTNP Sr/Ca-SST record and the Atlantic Multidecadal Oscillation (AMO) index, with the AMO lagging Sr/Ca-SST at DTNP by 9 years. Low frequency variability in the Gulf Stream surface transport, which originates near DTNP, may provide a link for the lagged relationship between multidecadal variability at DTNP and the AMO.

A Devil in the Details: Matrix-Dependent 40Ca42Ca++/42Ca+ and Its Effects on Estimates of the Initial 41Ca/40Ca in the Solar System

Science.gov (United States)

McKeegan, K. D.; Liu, M.-C.

2015-07-01

Ian Hutcheon established that the molecular ion interference 40Ca42Ca++/42Ca+ on 41K+ is strongly dependent on the mineral analyzed. Correction for this "matrix effect" led to a downward revision of the initial 41Ca/40Ca of the solar system.

USA pelgab Hiina tehnoloogialuuret / Tõnis Arnover

Index Scriptorium Estoniae

Arnover, Tõnis, 1952-

2005-01-01

Hiina Ameerika-vastasest majandusluurest. USA luureameti andmetel on USA-s loodud üle kolme tuhande Hiina firma, kelle ülesandeks on tööstusliku või sõjalise tehnoloogia hankimine. Vt. samas: Hiina firmad ostavad üha suuremaid USA ettevõtteid

Hydrolysis of molten CaCl2-CaF2 with additions of CaO

Directory of Open Access Journals (Sweden)

Espen Olsen

2017-10-01

Full Text Available Calcium halide based molten salts have recently attracted interest for a number of applications such as direct reduction of oxides for metal production and as liquefying agent in cyclic sorption processes for CO2 by CaO from dilute flue gases (Ca-looping. A fundamental aspect of these melts is the possible hydrolysis reaction upon exposure to gaseous H2O forming corrosive and poisonous hydrogen halides. In this work experiments have been performed investigating the formation of HCl and HF from a molten salt consisting of a 13.8 wt% CaF2 in CaCl2 eutectic exposed to a flowing gas consisting of 10 vol% H2O in N2. Hydrolysis has been investigated as function of content of CaO and temperature. HCl and HF are shown to be formed at elevated temperatures; HCl forms to a substantially larger extent than HF. Addition of CaO has a marked, limiting effect on the hydrolysis. Thermodynamic modeling of the reaction indicates activity coefficients for CaO above unity in the system. For cyclic CO2-capture based on thermal swing, it is advisable to keep the temperature in the carbonation (absorption reactor well below 850 ℃ while maintaining a high CaO content if molten CaCl2 is employed. Similar conclusions can be drawn with regards to CaF2.

EPICS controlled sample mounting robots at the GM/CA CAT

Energy Technology Data Exchange (ETDEWEB)

Makarov, O.A. [GM/CA-CAT, Biosciences Division, Argonne National Laboratory, 9700 South Cass Avenue, Bldg. 436D, Argonne, IL 60439-4861 (United States)], E-mail: makarov@anl.gov; Benn, R.; Corcoran, S.; Devarapalli, S.; Fischetti, R.; Hilgart, M.; Smith, W.W.; Stepanov, S.; Xu, S. [GM/CA-CAT, Biosciences Division, Argonne National Laboratory, 9700 South Cass Avenue, Bldg. 436D, Argonne, IL 60439-4861 (United States)

2007-11-11

GM/CA CAT at Sector 23 of the advanced photon source (APS) is an NIH funded facility for crystallographic structure determination of biological macromolecules by X-ray diffraction [R.F. Fischetti, et al., GM/CA canted undulator beamlines for protein crystallography, Acta Crystallogr. A 61 (2005) C139]. The facility consists of three beamlines; two based on canted undulators and one on a bending magnet. The scientific and technical goals of the CAT emphasize streamlined, efficient throughput for a variety of sample types, sizes and qualities, representing the cutting edge of structural biology research. For this purpose all three beamlines are equipped with the ALS-style robots [C.W.Cork, et al. Status of the BCSB automated sample mounting and alignment system for macromolecular crystallography at the Advanced Light Source, SRI-2003, San-Francisco, CA, USA, August 25-29, 2003] for an automated mounting of cryo-protected macromolecular crystals. This report summarizes software and technical solutions implemented with the first of the three operational robots at beamline 23-ID-B. The automounter's Dewar can hold up to 72 or 96 samples residing in six Rigaku ACTOR magazines or ALS-style pucks, respectively. Mounting of a crystal takes approximately 2 s, during which time the temperature of the crystal is maintained near that of liquid nitrogen.

USA toetus Eestile

Index Scriptorium Estoniae

2007-01-01

Ameerika Ühendriikide riigisekretär Condoleezza Rice kinnitas 3. mail 2007 telefonikõnes president Toomas Hendrik Ilvesele USA toetust Eestile ning tõsist muret Venemaa käitumise üle oma naaberriigi suhtes. Ilmunud ka: Meie Kodu 9. mai 2007, lk. 2, pealk.: USA riigisekretär Vabariigi Presidendile: Ühendriigid toetavad Eestit

Sacramento County, CA, USA

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

77 FR 6587 - Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA; Amended Certification...

Science.gov (United States)

2012-02-08

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-75,089; TA-W-75,089A] Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA; Amended Certification Regarding Eligibility... for Worker Adjustment Assistance on January 26, 2011, applicable to workers of StarTek USA, Inc...

Comparative study of BCS-BEC crossover theories above Tc: The nature of the pseudogap in ultracold atomic Fermi gases

International Nuclear Information System (INIS)

Chien, C.-C.; Guo Hao; He Yan; Levin, K.

2010-01-01

This article presents a comparison of two finite-temperature BCS-Bose-Einstein condensation (BEC) crossover theories above the transition temperature: Nozieres-Schmitt-Rink (NSR) theory and finite-T extended BCS-Leggett theory. The comparison is cast in the form of numerical studies of the behavior of the fermionic spectral function both theoretically and as constrained by (primarily) radio frequency (rf) experiments. Both theories include pair fluctuations and exhibit pseudogap effects, although the nature of this pseudogap is very different. The pseudogap in finite-T extended BCS-Leggett theory is found to follow a BCS-like dispersion which, in turn, is associated with a broadened BCS-like self-energy, rather more similar to what is observed in high-temperature superconductors (albeit, for a d-wave case). The fermionic quasiparticle dispersion is different in NSR theory and the damping is considerably larger. We argue that the two theories are appropriate in different temperature regimes with the BCS-Leggett approach being more suitable nearer to condensation. There should, in effect, be little difference at higher T as the pseudogap becomes weaker and where the simplifying approximations used in the BCS-Leggett approach break down. On the basis of momentum-integrated rf studies of unpolarized gases, it would be difficult to distinguish which theory is the better one. A full comparison for polarized gases is not possible since it is claimed that there are inconsistencies in the NSR approach (not found in the BCS-Leggett scheme). Future experiments along the lines of momentum-resolved experiments look to be very promising in distinguishing the two theories.

Value of Combined Detection of Serum CEA, CA72-4, CA19-9, CA15-3 and CA12-5 in the Diagnosis of Gastric Cancer.

Science.gov (United States)

Chen, Changguo; Chen, Qiuyuan; Zhao, Qiangyuan; Liu, Min; Guo, Jianwei

2017-05-01

To examine whether the combined detection of serum tumor markers (CEA, CA72-4, CA19-9, CA15-3 and CA12-5) improves the sensitivity and accuracy in the diagnosis of gastric cancer (GC). An automatic chemiluminescence immune analyzer with matched kits was used to determine the levels of serum CEA, CA72-4, CA19-9, CA15-3, and CA12-5 in 87 patients with gastric cancer (GC group), 60 patients with gastric benign diseases (GBD group) who were hospitalized during the same period, and 40 healthy subjects undergoing a physical examination. The values of these 5 tumor markers in the diagnosis of gastric cancer were analyzed. The levels of serum CEA, CA72-4, CA19-9, and CA12-5 were higher in the GC group than in the GBD group and healthy subjects, and these differences were significant ( P 0.05). The combined detection of CEA, CA72-4, CA19-9, and CA12-5 had a higher diagnostic value for gastric cancer than did single detection, and the positive detection rate of the combined detection of the four tumor markers was 60.9%. The diagnostic power when using the combined detection of CA72-4, CEA, CA19-9, and CA12-5 was the best. The combined detection of serum CA72-4, CEA, CA19-9 and CA12-5 increases the sensitivity and accuracy in the diagnosis of GC and can thus be considered an important tool for early diagnosis. © 2017 by the Association of Clinical Scientists, Inc.

Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.

Science.gov (United States)

Kim, Eun Young; Rumpf, Christine H; Van Petegem, Filip; Arant, Ryan J; Findeisen, Felix; Cooley, Elizabeth S; Isacoff, Ehud Y; Minor, Daniel L

2010-12-01

Interactions between voltage-gated calcium channels (Ca(V)s) and calmodulin (CaM) modulate Ca(V) function. In this study, we report the structure of a Ca(2+)/CaM Ca(V)1.2 C-terminal tail complex that contains two PreIQ helices bridged by two Ca(2+)/CaMs and two Ca(2+)/CaM-IQ domain complexes. Sedimentation equilibrium experiments establish that the complex has a 2:1 Ca(2+)/CaM:C-terminal tail stoichiometry and does not form higher order assemblies. Moreover, subunit-counting experiments demonstrate that in live cell membranes Ca(V)1.2s are monomers. Thus, contrary to previous proposals, the crystallographic dimer lacks physiological relevance. Isothermal titration calorimetry and biochemical experiments show that the two Ca(2+)/CaMs in the complex have different properties. Ca(2+)/CaM bound to the PreIQ C-region is labile, whereas Ca(2+)/CaM bound to the IQ domain is not. Furthermore, neither of lobes of apo-CaM interacts strongly with the PreIQ domain. Electrophysiological studies indicate that the PreIQ C-region has a role in calcium-dependent facilitation. Together, the data show that two Ca(2+)/CaMs can bind the Ca(V)1.2 tail simultaneously and indicate a functional role for Ca(2+)/CaM at the C-region site.

The site of net absorption of Ca from the intestinal tract of growing pigs and effect of phytic acid, Ca level and Ca source on Ca digestibility.

Science.gov (United States)

González-Vega, J Caroline; Walk, Carrie L; Liu, Yanhong; Stein, Hans H

2014-01-01

An experiment was conducted to test the hypothesis that the standardised digestibility of Ca in calcium carbonate and Lithothamnium calcareum Ca is not different regardless of the level of dietary Ca, and that phytic acid affects the digestibility of Ca in these two ingredients to the same degree. The objectives were to determine where in the intestinal tract Ca absorption takes place and if there are measurable quantities of basal endogenous Ca fluxes in the stomach, small intestine or large intestine. Diets contained calcium carbonate or L. calcareum Ca as the sole source of Ca, 0% or 1% phytic acid and 0.4% or 0.8% Ca. A Ca-free diet was also formulated and used to measure endogenous fluxes and losses of Ca. Nine growing pigs (initial body weight 23.8 ± 1.3 kg) were cannulated in the duodenum and in the distal ileum, and faecal, ileal and duodenal samples were collected. Duodenal endogenous fluxes of Ca were greater (p calcareum Ca diets, but that was not the case if calcium carbonate was the source of Ca (interaction, p calcareum Ca was greater (p calcareum Ca. In conclusion, under the conditions of this experiment, standardised digestibility of Ca is not affected by the level of phytic acid, but may be affected by dietary Ca level depending on the Ca source. Calcium from calcium carbonate is mostly absorbed before the duodenum, but Ca from L. calcareum Ca is mostly absorbed in the jejunum and ileum.

Contrasting chemical response to artificial acidification of three acid-sensitive streams in Maine, USA

International Nuclear Information System (INIS)

Goss, Heather V.; Norton, Stephen A.

2008-01-01

We experimentally acidified three low alkalinity first-order streams in forested catchments in Maine, USA. We evaluated water samples from a reference site above the point of hydrochloric acid addition and from two or three sites located 16 to 94 m downstream. Neutralization included protonation of weak acids, adsorption of sulfate, and ion exchange of base cations and aluminum (Al) for protons (H + ). Protonation of bicarbonate was significant in the relatively high pH Hadlock Brook. Protonation of weak organic acids dominated in the high dissolved organic carbon (DOC) Mud Pond Inlet. The response in low DOC, low pH East Bear Brook was dominated by stream substrate release of cations. East Bear Brook had the strongest acid neutralization response per unit catchment area. In all streams, exchangeable calcium (Ca) and magnesium (Mg) were mobilized, with Ca > Mg. Al was also mobilized. During initial stages of acidification, Ca desorbed preferentially, whereas Al mobilization dominated later. Early in the recovery, adsorption of Ca to the streambed sediments was kinetically favored over adsorption of Al. Though pH increased downstream of acid addition, the streams remained undersaturated with respect to amorphous Al(OH) 3 , so Al did not precipitate. In East Bear Brook, however, Al left solution further downstream through adsorption. This process was likely kinetically controlled, because it occurred in East Bear Brook (3-4 L/s) but did not occur in Hadlock Brook (ca. 40 L/s) or Mud Pond Inlet (ca. 60 L/s). During experimental acidification, the initial Al:Ca ratio of a stream's response may indicate the acidification status of the catchment. Short-term stream acidification experiments illuminate processes characteristic of episodic stream acidification and of long-term catchment acidification. East Bear Brook and Hadlock Brook catchments are in early to intermediate stages of acidification. The Mud Pond Inlet catchment (high Al:Ca ratio) is in a later stage of

Ca2+/cation antiporters (CaCA: Identification, characterization and expression profiling in bread wheat (Triticum aestivum L.

Directory of Open Access Journals (Sweden)

Mehak Taneja

2016-11-01

Full Text Available The Ca2+/cation antiporters (CaCA superfamily proteins play vital function in Ca2+ ion homeostasis, which is an important event during development and defense response. Molecular characterization of these proteins has been performed in certain plants, but they are still not characterized in Triticum aestivum (bread wheat. Herein, we identified thirty four TaCaCA superfamily proteins, which were classified into TaCAX, TaCCX, TaNCL and TaMHX protein families based on their structural organization and evolutionary relation with earlier reported proteins. Since the T. aestivum comprises an allohexaploid genome, TaCaCA genes were derived from each A, B and D subgenome and homeologous chromosome (HC, except chromosome-group 1. Majority of genes were derived from more than one HCs in each family that were considered as homeologous genes (HGs due to their high similarity with each other. These HGs showed comparable gene and protein structures in terms of exon/intron organization and domain architecture. Majority of TaCaCA proteins comprised two Na_Ca_ex domains. However, TaNCLs consisted of an additional EF-hand domain with calcium binding motifs. Each TaCaCA protein family consisted of about ten transmembrane and two α-repeat regions with specifically conserved signature motifs except TaNCL, which had single α-repeat. Variable expression of most of the TaCaCA genes during various developmental stages suggested their specified role in development. However, constitutively high expression of a few genes like TaCAX1-A and TaNCL1-B indicated their role throughout the plant growth and development. The modulated expression of certain genes during biotic (fungal infections and abiotic stresses (heat, drought, salt suggested their role in stress response. Majority of TaCCX and TaNCL family genes were found highly affected during various abiotic stresses. However the role of individual gene needs to be established. The present study unfolded the opportunity

Ca2+/Cation Antiporters (CaCA): Identification, Characterization and Expression Profiling in Bread Wheat (Triticum aestivum L.).

Science.gov (United States)

Taneja, Mehak; Tyagi, Shivi; Sharma, Shailesh; Upadhyay, Santosh Kumar

2016-01-01

The Ca 2+ /cation antiporters (CaCA) superfamily proteins play vital function in Ca 2+ ion homeostasis, which is an important event during development and defense response. Molecular characterization of these proteins has been performed in certain plants, but they are still not characterized in Triticum aestivum (bread wheat). Herein, we identified 34 TaCaCA superfamily proteins, which were classified into TaCAX, TaCCX, TaNCL, and TaMHX protein families based on their structural organization and evolutionary relation with earlier reported proteins. Since the T. aestivum comprises an allohexaploid genome, TaCaCA genes were derived from each A, B, and D subgenome and homeologous chromosome (HC), except chromosome-group 1. Majority of genes were derived from more than one HCs in each family that were considered as homeologous genes (HGs) due to their high similarity with each other. These HGs showed comparable gene and protein structures in terms of exon/intron organization and domain architecture. Majority of TaCaCA proteins comprised two Na_Ca_ex domains. However, TaNCLs consisted of an additional EF-hand domain with calcium binding motifs. Each TaCaCA protein family consisted of about 10 transmembrane and two α-repeat regions with specifically conserved signature motifs except TaNCL, which had single α-repeat. Variable expression of most of the TaCaCA genes during various developmental stages suggested their specified role in development. However, constitutively high expression of a few genes like TaCAX1-A and TaNCL1-B indicated their role throughout the plant growth and development. The modulated expression of certain genes during biotic (fungal infections) and abiotic stresses (heat, drought, salt) suggested their role in stress response. Majority of TaCCX and TaNCL family genes were found highly affected during various abiotic stresses. However, the role of individual gene needs to be established. The present study unfolded the opportunity for detail

USA võtab hoogu maha / Tarvo Vaarmets

Index Scriptorium Estoniae

Vaarmets, Tarvo

2010-01-01

Pärast riiklike soodustuste lõppu koduostjatele on USA-s vähenenud kinnisvara soetamine, jaemüüjate käive langes juunis võrreldes maiga 0,5%. USA keskpanga presidendi Ben Bernanke hinnangul on USA majandus ebatavaliselt ebamäärane

USA suursaadikuga Tallinna lahel / Katrin Kruss

Index Scriptorium Estoniae

Kruss, Katrin

2007-01-01

USA suursaadik Stanley Davis Phillips oma haridusteest, perekonnast, armastusest mere vastu, panusest isa Earl Phillipsi mööbliäri laiendamisse, golfiharrastusest, suursaadikute ettevalmistusest USA-s, suursaadiku residentsist Pirital ning uue saatkonnahoone otsingutest Tallinnas. Lisa: Stanley Davis Phillips

Radiocarbon constraints on fossil thinolite tufa formation in the Mono Basin, CA, USA

Science.gov (United States)

Leroy, S. L.; Zimmerman, S. R.; Hemming, S. R.; Stine, S.; Guilderson, T. P.

2009-12-01

Mono Lake is a terminal lake located at the western edge of the Great Basin, and is famous for its tufa towers. Thinolite, which is thought to be a CaCO3 pseudomorph of ikaite, is found around the Mono Basin in many fossil tufa towers, particularly at elevations above 2000 meters. The subaqueous parent mineral ikaite forms at low temperatures (34 kyr) to as young as 15.5 14C kyr BP. In general there is a consistent stratigraphic trend of ages within the mound, but the thinolite ages are anomalously young and one thinolite sample shows a large age reversal. The best estimate of the age of the precipitation of this tufa mound is given by the non-thinolite textures. More work is needed to determine the best sampling and sample preparation strategies in order to get a reliable age model for this mound.

Water Content in the SW USA Mantle Lithosphere: FTIR Analysis of Dish Hill and Kilbourne Hole Pyroxenites

Science.gov (United States)

Gibler, Robert; Peslier, Anne H.; Schaffer, Lillian Aurora; Brandon, Alan D.

2014-01-01

Kilbourne Hole (NM, USA) and Dish Hill (CA, USA) mantle xenoliths sample continental mantle in two different tectonic settings. Kilbourne Hole (KH) is located in the Rio Grande rift. Dish Hill (DH) is located in the southern Mojave province, an area potentially affected by subduction of the Farallon plate beneath North America. FTIR analyses were obtained on well characterized pyroxenite, dunite and wehrlite xenoliths, thought to represent crystallized melts at mantle depths. PUM normalized REE patterns of the KH bulk-rocks are slightly LREE enriched and consistent with those of liquids generated by 6% melting of a spinel peridotite source. Pyroxenite pyroxenes have no detectable water but one DH wehrlite, which bulk-rock is LREE enriched, has 4 ppm H2O in orthopyroxene and 2 Ga. The Farallon subduction appears to have enriched in water the southwestern United States lithospheric mantle further east than DH, beneath the Colorado plateau.

Control of ciliary motility by Ca2+: Integration of Ca2+-dependent functions and targets for Ca2+ action

International Nuclear Information System (INIS)

Evans, T.C.

1988-01-01

To identify functions that regulate Ca 2+ -induced ciliary reversal in Paramecium, mutants defective in terminating depolarization-induced backward swimming were selected. Six independent recessive mutations (k-shy) comprising two complementation groups, k-shyA and k-shyB, were identified. All mutants exhibited prolonged backward swimming in depolarizing solutions. Voltage clamp studies revealed that mutant Ca 2+ current amplitudes were reduced, but could be restored to wild type levels by EGTA injection. The recovery of the mutant Ca 2+ current from Ca 2+ -dependent inactivation, and the decay of the Ca 2+ -dependent K + and Ca 2+ -dependent Na + currents after depolarization were slow in k-shy compared to wild type. To identify protein targets of Ca 2+ action, ciliary proteins that interact with calmodulin (CaM) were characterized. With a 125 I-CaM blot assay, several CaM-binding proteins were identified including axonemal, soluble, and membrane-bound polypeptides. Competitive displacement studies with unlabeled Paramecium CaM, bovine CaM, and troponinC suggested that both protein types bind CaM with high affinity and specificity. To examine the presence of CaM-binding sites in intact axonemes, a filtration binding assay was developed

Quebec-USA electricity export contracts

International Nuclear Information System (INIS)

Labbe, J.-F.

1993-06-01

Electricity exports from Hydro-Quebec to utilities in the USA significantly affects the economy and environment of Quebec. These exports may be arranged under interconnection agreements to sell excess capacity and production during off-peak periods or under firm sales contracts. Hydro-Quebec exports could also replace power plants that would otherwise be needed in the USA. The economic environment for Hydro-Quebec exports to the USA is reviewed along with the regulatory environment applicable to international trade (General Agreement on Tariffs and Trade, Canada-USA Free Trade Agreement, North American Free Trade Agreement), Quebec (Canadian federal and provincial law), and the USA (federal and state law). A jurisdictional analysis of power export contracts is then presented, citing examples of contracts already signed by Hydro-Quebec with utilities in New York and New England. Contract law and contract provisions are discussed, including common clauses and particular clauses. Suggestions are made for new clauses that would improve the electricity trade. 215 refs., 13 figs., 3 tabs

An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis.

Directory of Open Access Journals (Sweden)

Wei Xiong

Full Text Available AIM: Neurotransmitter release is elicited by an elevation of intracellular Ca(2+ concentration ([Ca(2+](i. The action potential triggers Ca(2+ influx through Ca(2+ channels which causes local changes of [Ca(2+](i for vesicle release. However, any direct role of extracellular Ca(2+ (besides Ca(2+ influx on Ca(2+-dependent exocytosis remains elusive. Here we set out to investigate this possibility on rat dorsal root ganglion (DRG neurons and chromaffin cells, widely used models for studying vesicle exocytosis. RESULTS: Using photolysis of caged Ca(2+ and caffeine-induced release of stored Ca(2+, we found that extracellular Ca(2+ inhibited exocytosis following moderate [Ca(2+](i rises (2-3 µM. The IC(50 for extracellular Ca(2+ inhibition of exocytosis (ECIE was 1.38 mM and a physiological reduction (∼30% of extracellular Ca(2+ concentration ([Ca(2+](o significantly increased the evoked exocytosis. At the single vesicle level, quantal size and release frequency were also altered by physiological [Ca(2+](o. The calcimimetics Mg(2+, Cd(2+, G418, and neomycin all inhibited exocytosis. The extracellular Ca(2+-sensing receptor (CaSR was not involved because specific drugs and knockdown of CaSR in DRG neurons did not affect ECIE. CONCLUSION/SIGNIFICANCE: As an extension of the classic Ca(2+ hypothesis of synaptic release, physiological levels of extracellular Ca(2+ play dual roles in evoked exocytosis by providing a source of Ca(2+ influx, and by directly regulating quantal size and release probability in neuronal cells.

Nordkorea kan endelig ramme USA

DEFF Research Database (Denmark)

Jakobsen, Peter Viggo

2017-01-01

Nordkoreas evne til at nå USA baner vej for en forhandlet løsning, fordi præsident Trump ikke har andre alternativer. Krig vil koste over en million døde, og Kina er imod effektive sanktioner. Det nødvendige pres for at få USA til forhandlingsbordet er nu på plads.......Nordkoreas evne til at nå USA baner vej for en forhandlet løsning, fordi præsident Trump ikke har andre alternativer. Krig vil koste over en million døde, og Kina er imod effektive sanktioner. Det nødvendige pres for at få USA til forhandlingsbordet er nu på plads....

Pepeljajev eesti näitlejatega USA-s

Index Scriptorium Estoniae

2008-01-01

Sasha Pepeljajevi tantsulavastust "Uksed" etendati USA rahvusvahelisel teatrifestivalil "Arts & Ideas". Vene-Eesti trupi Apparatus lavastus on pühendatud Daniil Harmsi 100. sünniaastapäevale ning põhineb tema töödel

The strategic interests of the USA, Russia and Сhina in the central Asia at the present stage

Directory of Open Access Journals (Sweden)

Tofan A.V.

2016-12-01

Full Text Available this article is devoted to develop and analyze the strategic concerns of key geopolitical actors in the Central Asian region. The author comes to the conclusion that the specialty of the Central Asia is a beneficial geopolitical location and great amount of nature resources that makes the region an object of world powers’ geopolitical interests. The main actors in the CA are the USA, China and Russia, which have influence on political processes inside the region, realizing their own strategies.

Glemmer USA Afghanistan nu?

DEFF Research Database (Denmark)

Jakobsen, Peter Viggo

2015-01-01

Hvis Obamas efterfølger kan skrue den rigtige strategiske fortælling sammen så vil USA ikke forlade Afghanistan med udgangen af 2016.......Hvis Obamas efterfølger kan skrue den rigtige strategiske fortælling sammen så vil USA ikke forlade Afghanistan med udgangen af 2016....

Reduced endogenous Ca2+ buffering speeds active zone Ca2+ signaling.

Science.gov (United States)

Delvendahl, Igor; Jablonski, Lukasz; Baade, Carolin; Matveev, Victor; Neher, Erwin; Hallermann, Stefan

2015-06-09

Fast synchronous neurotransmitter release at the presynaptic active zone is triggered by local Ca(2+) signals, which are confined in their spatiotemporal extent by endogenous Ca(2+) buffers. However, it remains elusive how rapid and reliable Ca(2+) signaling can be sustained during repetitive release. Here, we established quantitative two-photon Ca(2+) imaging in cerebellar mossy fiber boutons, which fire at exceptionally high rates. We show that endogenous fixed buffers have a surprisingly low Ca(2+)-binding ratio (∼ 15) and low affinity, whereas mobile buffers have high affinity. Experimentally constrained modeling revealed that the low endogenous buffering promotes fast clearance of Ca(2+) from the active zone during repetitive firing. Measuring Ca(2+) signals at different distances from active zones with ultra-high-resolution confirmed our model predictions. Our results lead to the concept that reduced Ca(2+) buffering enables fast active zone Ca(2+) signaling, suggesting that the strength of endogenous Ca(2+) buffering limits the rate of synchronous synaptic transmission.

Sõda, mille USA on juba kaotanud / Mart Helme

Index Scriptorium Estoniae

Helme, Mart, 1949-

2003-01-01

USA pole suutnud Iraagi-vastase sõja vajalikkust põhjendada, arvavad paljud USA poliitikavaatlejad. Rängaks diplomaatiliseks eksimuseks peetakse USA kaitseministri Donald Rumsfeldi avaldust, et USA ei vaja kellegi abi sõjas

TTÜ ja TÜ osalevad USA armee miljoniprojektides

Index Scriptorium Estoniae

2016-01-01

TTÜ ja TÜ liitusid USA-s tegutseva meditsiinitehnoloogia ettevõtete konsortsiumiga. Nii jõuavad juhtivate Eesti kõrgkoolide teadmised USA armeesse, kes konsortsiumi kaudu innovaatilisi tooteid ja teenuseid sisse ostab

Photoemission study of Ca-intercalated graphite superconductor CaC6

International Nuclear Information System (INIS)

Okazaki, Hiroyuki; Yoshida, Rikiya; Iwai, Keisuke; Noami, Kengo; Muro, Takayuki; Nakamura, Tetsuya; Wakita, Takanori; Muraoka, Yuji; Hirai, Masaaki; Tomioka, Fumiaki; Takano, Yoshihiko; Takenaka, Asami; Toyoda, Masahiro; Oguchi, Tamio; Yokoya, Takayoshi

2010-01-01

In this work, we have performed resonant photoemission studies of Ca-intercalated graphite superconductor CaC 6 . Using photon energy of the Ca 2p-3d threshold, the photoemission intensity of the peak at Fermi energy (E F ) is resonantly enhanced. This result provides spectroscopic evidence for the existence of Ca 3d states at E F , and strongly supports that Ca 3d state plays a crucial role for the superconductivity of this material with relatively high T c .

Det sorte USA

DEFF Research Database (Denmark)

Brøndal, Jørn

Bogen gennemgår det sorte USAs historie fra 1776 til 2016, idet grundtemaet er spændingsforholdet mellem USAs grundlæggelsesidealer og den racemæssige praksis, et spændingsforhold som Gunnar Myrdal kaldte "det amerikanske dilemma." Bogen, der er opbygget som politisk, social og racemæssig histori......, er opdelt i 13 kapitler og består af fire dele: Første del: Slaveriet; anden del: Jim Crow; tredje del. King-årene; fjerde del: Frem mod Obama....

Solubility of calcium in CaO-CaCl2

International Nuclear Information System (INIS)

Perry, G.S.; Shaw, S.J.

1991-06-01

The Direct Oxide Reduction (DOR) process is well established as a process to produce plutonium metal from plutonium dioxide by reaction with calcium. Calcium chloride is added to dissolve the calcium oxide produced, allowing the metal to coalesce into a button. Since calcium metal melts at 840 0 C and DOR can take place successfully below this temperature, it is likely calcium dissolved in calcium chloride reacts with the plutonium dioxide. The solubility of calcium in calcium chloride is reasonably well established but the effect of the CaO formed during the DOR process on the solubility of calcium has not been previously determined. For this reason the solubility of calcium in CaCl 2 -CaO melts at 800 o C has been studied. The solubility decreases from 2.7 mol % in CaCl 2 to 0.4 mol % in 9 mol % CaO-CaCl 2 . (author)

USA suursaadik : hirmud on alistanud lootuse / Toomas Sildam

Index Scriptorium Estoniae

Sildam, Toomas, 1961-

2004-01-01

Eestist lahkuv USA suursaadik Joseph de Thomas andis USA iseseisvuspäeva kõnes hinnangu Eesti toetusele Iraagis ja USA Iraagi-poliitikale. Parlamendiliige Eiki Berg USA suursaadiku kõnest. Vt. ka: Suursaadiku sõnum lk. 10

USA tankid jõudsid Tapale

Index Scriptorium Estoniae

2017-01-01

Tapale saabus poolsada USA sõjamasinat, nende seas neli tanki Abrams M1A2 ja 15 jalaväe lahingumasinat Bradley. Tehnikat hakkab kasutama USA maaväe 4. jalaväediviisi 68. soomusrügemendi esimese pataljoni C-kompanii

USA NCAP - a glance at harmonization

Energy Technology Data Exchange (ETDEWEB)

Morgan, R.M.; Park, B.T.; Beuse, N.M.; Lowrie, J.C. [National Highway Traffic Safety Administration, Washington, DC (United States); Swanson, J.L.; Rockwell, T.E. [ACE Systems Technologies, Inc. (United States)

2001-07-01

This paper is separated roughly into four parts. First, the authors discuss the frontal tests of the USA New Car Assessment Program (NCAP) and then consider similarities and differences in the two different types of frontal tests worldwide. Second, the focus is placed on the side crash of the USA NCAP and comparisons are made between the results of the two different types of lateral tests worldwide. Third, the paper explains the Congressional requirements to establish a child safety rating system (in the USA) by model year 2003 and looks at the approach taken by NCAPs worldwide. Finally, the growth in requests for consumer information (in the USA) is measured. (orig.)

USA tahab Iraagilt täispuutumatust / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2008-01-01

USA ja Iraagi läbirääkimised USA vägede staatuse üle venivad, USA soovib oma sõduritele täielikku immuniteeti. Iraak olevat nõus nende USA üksuste immuniteediga, kes on sõjalistes rajatistes või missioonil, milles on varem kokku lepitud

Comparative kinetics of 47Ca, 85Sr and 226Ra in the freshwater turtle, Trachemys scripta

International Nuclear Information System (INIS)

Hinton, T.G.; Whicker, F.W.; Ibrahim, S.A.; Pinder, J.E. III

1992-01-01

The kinetics of 47 Ca, 85 Sr and 226 Ra were compared in the yellow-bellied slider, a common freshwater turtle of the southeastern USA. The absorption and elimination processes were examined as a function of stable dietary Ca, season, age and sex of the animals. Turtles were gavaged with radionuclides and serial whole-body analyses were performed on the live animals for up to 480 days. Only in the juvenile age class did reduced dietary Ca cause a significant increase in 85 Sr absorption. The absorption of 85 Sr and 226 Ra in the adult male, adult female and hatchling groups was unaffected by dietary Ca. Mean absorption was greater than that which has been reported for other organisms and significantly differed among isotopes. The high absorption values were not restricted to immatures, but continued into maturity. Elimination rates were not affected by the dietary treatment, nor were isotopic differences in elimination observed. Annual mean elimination rate constants pooled among animal groups, were 0.22 ± 0.07 for 85 Sr and 0.26 ± 0.18 for 226 Ra. Retention was strongly affected by season with the greatest elimination occurring in the summer and declining to levels that were not distinguishable from zero in the winter. Elimination rate constants for hatchlings were greater than for the other age groups. (author)

USA andis Gruusiale vastakaid signaale / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2008-01-01

USA välisministri Condoleezza Riceþi saabumisest Thbilisisse, et avaldada Gruusiale toetust. USA poolt antud soovitustest Gruusia president Mihhail Saakashvilile mitte jõudu kasutada ega alluda Venemaa provokatsioonidele ning hoiatustest sõjalise konflikti tagajärgede eest. USA analüütikute arvamusi

Lahingustress ajab USA sõdurid jooma / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2007-01-01

Ilmunud ka: Postimees : na russkom jazõke, 15. märts 2007, lk. 10. USA kaitseministeeriumi siseuurimuse kohaselt kasvas alkoholi kuritarvitamine tegevteenistuses olevate USA sõjaväelaste seas aastatel 2002-2005 enam kui 30%. Alkoholi ja uimastite tarvitamisest Iraagis ja Afganistanis teenivate USA sõdurite hulgas. Vt. samas: USA relvajõududes puhkes uus homoskandaal

The energy situation in the Usa

International Nuclear Information System (INIS)

2006-01-01

This analyses discusses the energy supplying security, the natural gas demand increase and its consequences, the climatic change in the long-dated, the long dated perspectives of the Usa energy policy, the law on the energy and the consequences for the nuclear activity, the financial incentives in favor of the construction of new nuclear power plants in the Usa and the good nuclear energy industry situation in the Usa. (A.L.B.)

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak

Science.gov (United States)

Sankaranarayanan, Rajiv; Li, Yatong; Greensmith, David J.; Eisner, David A.

2016-01-01

Key points Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca transient and slows its rate of decay.In the presence of β‐adrenergic stimulation, RyR‐mediated Ca leak produces a biphasic decay of the Ca transient with a fast early phase and a slow late phase.Two forms of Ca leak have been studied, Ca‐sensitising (induced by caffeine) and non‐sensitising (induced by ryanodine) and both induce biphasic decay of the Ca transient.Only Ca‐sensitising leak can be reversed by traditional RyR inhibitors such as tetracaine.Ca leak can also induce Ca waves. At low levels of leak, waves occur. As leak is increased, first biphasic decay and then slowed monophasic decay is seen. The level of leak has major effects on the shape of the Ca transient. Abstract In heart failure, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of the SR Ca ATPase (SERCA). We have characterised the effects of two forms of Ca leak (Ca‐sensitising and non‐sensitising) on calcium cycling and compared with those of SERCA inhibition. We measured [Ca2+]i with fluo‐3 in voltage‐clamped rat ventricular myocytes. Increasing SR leak with either caffeine (to sensitise the RyR to Ca activation) or ryanodine (non‐sensitising) had similar effects to SERCA inhibition: decreased systolic [Ca2+]i, increased diastolic [Ca2+]i and slowed decay. However, in the presence of isoproterenol, leak produced a biphasic decay of the Ca transient in the majority of cells while SERCA inhibition produced monophasic decay. Tetracaine reversed the effects of caffeine but not of ryanodine. When caffeine (1 mmol l−1) was added to a cell which displayed Ca waves, the wave frequency initially increased before waves disappeared and biphasic decay developed. Eventually (at higher caffeine concentrations), the

crdi.ca

International Development Research Centre (IDRC) Digital Library (Canada)

et des enfants d'Afrique. INITIATIVE CONCERTÉE. Innovation pour la santé des mères et des enfants d'Afrique. Centre de recherches pour le développement international. CP Box 8500 Ottawa ON Canada K1G 3H9. Téléphone : +1 613 236 6163 • Télécopieur : +1 613 657 7749 ismea@crdi.ca | www.crdi.ca/ismea crdi.ca.

Characterization of Bacillus subtilis YfkE (ChaA): a calcium-specific Ca2+/H+ antiporter of the CaCA family.

Science.gov (United States)

Fujisawa, Makoto; Wada, Yuko; Tsuchiya, Takahiro; Ito, Masahiro

2009-08-01

YfkE, a protein from Bacillus subtilis, exhibits homology to the Ca(2+):Cation Antiporter (CaCA) Family. In a fluorescence-based assay of everted membrane vesicles prepared from Na(+)(Ca(2+))/H(+) antiporter-defective mutant Escherichia coli KNabc, YfkE exhibited robust Ca(2+)/H(+) antiport activity, with a K (m) for Ca(2+) estimated at 12.5 muM at pH 8.5 and 113 muM at pH 7.5. Neither Na(+) nor K(+) served as a substrate. Mg(2+) also did not serve as a substrate, but inhibited the Ca(2+)/H(+) antiporter activity. The Ca(2+) transport capability of YfkE was also observed directly by transport assays in everted membrane vesicles using radiolabeled (45)Ca(2+). Transcriptional analysis from the putative yfkED operon using beta-garactosidase activity as a reporter revealed that both of the yfkE and yfkD genes are regulated by forespore-specific sigma factor, SigG, and the general stress response regulator, SigB. These results suggest that YfkE may be needed for Ca(2+) signaling in the sporulation or germination process in B. subtilis. ChaA is proposed as the designation for YfkE of B. subtilis.

PREFACE: Polycrystal Modelling with Experimental Integration: A Symposium Honoring Carlos Tomé (San Diego, CA, USA, February 27-March 3 2011) Polycrystal Modelling with Experimental Integration: A Symposium Honoring Carlos Tomé (San Diego, CA, USA, February 27-March 3 2011)

Science.gov (United States)

Lebensohn, Ricardo A.

2012-03-01

This special issue contains selected contributions from invited speakers to the 'Polycrystal Modelling with Experimental Integration: A Symposium Honoring Carlos Tomé', held as part of the 2011 TMS Annual Meeting and Exhibition, that took place on February 27-March 3, 2011 in San Diego, CA, USA. This symposium honored the remarkable contributions of Dr Carlos N Tomé to the field of mechanical behavior of polycrystalline materials, on the occasion of his 60th birthday. Throughout his career, Dr Tomé has pioneered the theoretical and numerical development of models of polycrystal mechanical behavior, with emphasis on the role played by texture and microstructure on the anisotropic behavior of engineering materials. His many contributions have been critical in establishing a strong connection between models and experiments, and in bridging different scales in the pursuit of robust multiscale models with experimental integration. Among his achievements, the numerical codes that Dr Tomé and co-workers have developed are extensively used in the materials science and engineering community as predictive tools for parameter identification, interpretation of experiments, and multiscale calculations in academia, national laboratories and industry. The symposium brought together materials scientists and engineers to address current theoretical, computational and experimental issues related to microstructure-property relationships in polycrystalline materials deforming in different regimes, including the effects of single crystal anisotropy, texture and microstructure evolution. Synergetic studies, involving different crystal plasticity-based models, including multiscale implementations of the latter, and measurements of global and local textures, internal strains, dislocation structures, twinning, phase distribution, etc, were discussed in more than 90 presentations. The papers in this issue are representative of the different length-scales, materials, and experimental and

Comparative study of anisotropic superconductivity in CaAlSi and CaGaSi

International Nuclear Information System (INIS)

Tamegai, T.; Uozato, K.; Kasahara, S.; Nakagawa, T.; Tokunaga, M.

2005-01-01

In order to get some insight into the origin of the anomalous angular dependence of H c2 in a layered intermetallic compound CaAlSi, electronic, superconducting, and structural properties are compared between CaAlSi and CaGaSi. The angular dependence of H c2 in CaGaSi is well described by the anisotropic GL model. Parallel to this finding, the pronounced lattice modulation accompanying the superstructure along the c-axis in CaAlSi is absent in CaGaSi. A relatively large specific heat jump at the superconducting transition in CaAlSi compared with CaGaSi indicates the presence of strong electron-phonon coupling in CaAlSi, which may cause the superstructure and the anomalous angular dependence of H c2

Mass yield distributions for the reactions Ca+Ca, Nb+Nb and Ca+Ca at E/A=800 MeV in the molecular-dynamical model

International Nuclear Information System (INIS)

Kiselev, S.M.

1987-01-01

Mass yield distributions obtained on the basis of the molecular-dynamical model are presented for the Ca+Ca, Nb+Nb reactions at E/A=400 MeV and Ca+Ca reaction at E/A=800 MeV. For the fragments with masses upto quarter of the mass of initial nucleus the model predicts a power law for mass spectra with almost the same value of the exponent. Such the behaviour is roughly a result of the superposition of the fireball breakup and the disintegration of spectator regions rather than the evidence of a liquid-gas-like phase transition in hot nuclear matter

Eesti ja USA sõlmisid kokkuleppe

Index Scriptorium Estoniae

2017-01-01

Kaitseminister Margus Tsahkna ja Ameerika Ühendriikide suursaadik Eestis James Melville allkirjastasid Eesti ja USA kaitsekoostöö kokkuleppe, mis hakkab reguleerima Eestis viibivate USA relvajõudude liikmete, nende pereliikmete ja lepinglaste õiguslikku staatust

USA otsib Iraanist aktiivselt tuumainfot / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2005-01-01

Iraan avaldas protesti USA luurelendude üle Iraani kohal. USA endine kaitseminister James Baker peab Iraani ja Põhja-Koreaga nende tuumaprogrammide hävitamiseks sõja alustamist suurimaks veaks. Kuigi Bushi meeskond rõhutab vajadust lahendada küsimus rahumeelselt, toovad Dick Cheney' ja Condoleezza Rice'i avaldused mitme USA kommentaatori arvates meelde Iraagi sõja eelse taktika

USA-reis nõuab biomeetrilist passi / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2004-01-01

USA-s pikendati viisavabastusprogrammi biomeetrilise passi tähtaega 2005. aasta 26. oktoobrini. USA Eesti-saatkonna töötaja Christopher Smithi sõnul ei kehti viisavabadusprogrammi raames reisimise puhul passid, mida ei saa masinaga lugeda

Ventral tegmental area disruption selectively affects CA1/CA2 but not CA3 place fields during a differential reward working memory task.

Science.gov (United States)

Martig, Adria K; Mizumori, Sheri J Y

2011-02-01

Hippocampus (HPC) receives dopaminergic (DA) projections from the ventral tegmental area (VTA) and substantia nigra. These inputs appear to provide a modulatory signal that influences HPC dependent behaviors and place fields. We examined how efferent projections from VTA to HPC influence spatial working memory and place fields when the reward context changes. CA1 and CA3 process environmental context changes differently and VTA preferentially innervates CA1. Given these anatomical data and electrophysiological evidence that implicate DA in reward processing, we predicted that CA1 place fields would respond more strongly to both VTA disruption and changes in the reward context than CA3 place fields. Rats (N = 9) were implanted with infusion cannula targeting VTA and recording tetrodes aimed at HPC. Then they were tested on a differential reward, win-shift working memory task. One recording session consisted of 5 baseline and 5 manipulation trials during which place cells in CA1/CA2 (N = 167) and CA3 (N = 94) were recorded. Prior to manipulation trials rats were infused with either baclofen or saline and then subjected to control or reward conditions during which the learned locations of large and small reward quantities were reversed. VTA disruption resulted in an increase in errors, and in CA1/CA2 place field reorganization. There were no changes in any measures of CA3 place field stability during VTA disruption. Reward manipulations did not affect performance or place field stability in CA1/CA2 or CA3; however, changes in the reward locations "rescued" performance and place field stability in CA1/CA2 when VTA activity was compromised, perhaps by trigging compensatory mechanisms. These data support the hypothesis that VTA contributes to spatial working memory performance perhaps by maintaining place field stability selectively in CA1/CA2. Copyright © 2009 Wiley-Liss, Inc.

USA allveelaev uputas kalalaeva / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2001-01-01

Hawaii lähistel õppustel kiiret pinnaletõusu harjutanud USA allveelaev USS Greeneville põrkas kokku Jaapani õppelaevaga Ehime Maru, õnnetuse tagajärjel hukkus tõenäoliselt 9 jaapanlast. Skeem: Õnnetused USA allveelaevadega

Eesti on USA uus lemmik / Argo Ideon

Index Scriptorium Estoniae

Ideon, Argo, 1966-

2007-01-01

President Toomas Hendrik Ilvese visiidist Washingtoni, kohtumistest USA presidendi George W. Bushi, asepresident Dick Cheney, asevälisminister John Negroponte, kaitseminister Robert M. Gates'i, USA Kongressi esindajatekoja spiikri Nancy Pelosi ja kongresmenidega. Eestil õnnestus korraldada USA pealinnas kohtumised, mille järjekorras ootab hulk palju suuremaid riike. Vabariigi President töövisiidil Ameerika Ühendriikides 25.-26.06.2007

Extremely Elevated CA 125 and CA 19-9 in Endometrioma; A Case Series

Directory of Open Access Journals (Sweden)

Vugar Bayramov

2010-03-01

Full Text Available Although endometriosis is a benign condition, increased levels of the tumor markers CA 125 and CA 19-9 may be seen. However, these tumor markers reach to very high levels, rarely. In this report, 4 patients between 20 and 43 year-old with extremely elevated CA 125, CA 19-9 and CA 15-3 levels are discussed. In endometriosis extremely increased tumor markers are determined in the case of ruptured endometrioma cyst. There are two mechanisms to clarify extremely elevated levels of CA 125 in endometriosis. First, the peritoneal irritation of CA 125 molecule after the rupture of endometioma cyst and CA 125 secretion from the periton. And the second is penetration of the CA 125 moecule easily to the circulation through the peritoneal endothelial surface after the cyst rupture. In conclusion, the diagnosis of ruptured endometrioma cyst should be kept in mind especially in young patients with extremely elevated serum CA 125 levels with regard to the history and ultrasonographical signs and invasive procedures should be avoided.

Ca isotopes in refractory inclusions

International Nuclear Information System (INIS)

Niederer, F.R.; Papanastassiou, D.A.

1984-01-01

We report measurements of the absolute isotope abundance of Ca in Ca-Al-rich inclusions from the Allende and Leoville meteorites. Improved high precision measurements are reported also for 46 Ca. We find that nonlinear isotope effects in Ca are extremely rare in these inclusions. The absence of nonlinear effects in Ca, except for the effects in FUN inclusions, is in sharp contrast to the endemic effects in Ti. One fine-grained inclusion shows an excess of 46 Ca of (7 +- 1) per mille, which is consistent with addition of only 46 Ca or of an exotic (*) component with 46 Ca* approx. 48 Ca*. FUN inclusion EK-1-4-1 shows a small 46 Ca excess of (3.3 +- 1.0) per mille; this confirms that the exotic Ca components in EK-1-4-1 were even more deficient in 46 Ca relative to 48 Ca than is the case for normal Ca. The Ca in the Ca-Al-rich inclusions shows mass dependent isotope fractionation effects which have a range from -3.8 to +6.7 per mille per mass unit difference. This range is a factor of 20 wider than the range previously established for bulk meteorites and for terrestrial and lunar samples. Ca and Mg isotope fractionation effects in the Ca-Al-rich inclusions are common and attributed to kinetic isotope effects. (author)

Clinical evaluation of CEA, CA19-9, CA72-4 and CA125 in gastric cancer patients with neoadjuvant chemotherapy.

Science.gov (United States)

Sun, Zhipeng; Zhang, Nengwei

2014-12-29

In the clinical practice of neoadjuvant chemotherapy, response markers are very important. We aimed o investigate whether tumor markers CEA(carcino-embryonic antigen), CA19-9(carbohydrate antigen 19-9), CA72-4(carbohydrate antigen 72-4), and CA125(carbohydrate antigen 125) can be used to evaluate the response to neoadjuvant chemotherapy, and to evaluate the diagnosis and prognosis value of four tumor markers in the patients of gastric cancer. A retrospective review was performed of 184 gastric cancer patients who underwent a 5-Fu, leucovorin, and oxaliplatin (FOLFOX) neoadjuvant chemotherapy regimen, followed by surgical treatment. Blood samples for CEA, CA19-9, CA72-4, and CA125 levels were taken from patients upon admission to the hospital and after neoadjuvant chemotherapy. Statistical analysis was performed to identify the clinical value of these tumor markers in predicting the survival and the response to neoadjuvant chemotherapy. Median overall survival times of pretreatment CA19-9-positive and CA72-4-positive patients (14.0 +/-2.8 months and 14.8 +/-4.0 months, respectively) were significantly less than negative patients (32.5 +/-8.9 months and 34.0 +/-10.1 months, respectively) (P = 0.000 and P = 0.002, respectively). Pretreatment status of CA19-9 and CA72-4 were independent prognostic factors in gastric cancer patients (P = 0.029 and P = 0.008, respectively). Pretreatment CEA >50 ng/ml had a positive prediction value for clinical disease progression after neoadjuvant chemotherapy according to the ROC curve (AUC: 0.694, 95% CI: 0.517 to 0.871, P = 0.017). The decrease of tumor markers CEA, CA72-4, and CA125 was significant after neoadjuvant chemotherapy (P = 0.030, P = 0.010, and P = 0.009, respectively), especially in patients with disease control (including complete, partial clinical response, and stable disease) (P = 0.012, P = 0.020, and P = 0.025, respectively). A decrease in CA72-4 by more than 70% had

Quo vadis, USA dollar? : finantsturgude viimastest arengutest / Robert Liljequist

Index Scriptorium Estoniae

Liljequist, Robert

2013-01-01

Swedbank AB Soome strateegiajuht vastab küsimustele, mis puudutavad USA majandust alanud aastal, dollari n.-ö turvalise valuuta staatuse kaotamise ohtu, võlakirjade ostmise vähendamist ja selle mõju USA dollarile, Euroopa Keskpanga poliitika mõju euro ja USA dollari suhtele. Swebanki prognoos USA dollari kohta

The climate protection policy of the USA under president Obama; Die Klimaschutzpolitik der USA unter Praesident Obama

Energy Technology Data Exchange (ETDEWEB)

Fischer, Wolfgang; Schenk, Olga [Forschungszentrum Juelich (Germany). Inst. fuer Energieforschung - Systemforschung und Technologische Entwicklung; Holtrup-Mostert, Petra [Transatlantic Networks - Foreign Policy Analysis, Koenigswinter (Germany)

2009-01-15

Barack Obama's slogan 'Are you ready for a Change?' may become the motto fo the future climate protection policy of the USA. While the USA is slowly beginning to play a more active role in this area, there are many political and institutional obstacles to overcome before the USA can become one of the big global players here. The authors analyse the status quo of the US climate protection policy in an attempt to indicate national and international perspectives of climate protection. (orig.)

Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer.

Science.gov (United States)

Gao, Yanfeng; Wang, Jinping; Zhou, Yue; Sheng, Sen; Qian, Steven Y; Huo, Xiongwei

2018-02-09

Blood-based protein biomarkers have recently shown as simpler diagnostic modalities for colorectal cancer, while their association with clinical pathological characteristics is largely unknown. In this study, we not only examined the sensitivity and reliability of single/multiple serum markers for diagnosis, but also assessed their connection with pathological parameters from a total of 279 colorectal cancer patients. Our study shown that glycoprotein carcinoembryonic antigen (CEA) owns the highest sensitivity among single marker in the order of CEA > cancer antigen 72-4 (CA72-4) > cancer antigen 19-9 9 (CA19-9) > ferritin > cancer antigen 125 (CA125), while the most sensitive combined-markers for two to five were: CEA + CA72-4; CEA + CA72-4 + CA125; CEA + CA19-9 + CA72-4 + CA125; and CEA + CA19-9 + CA72-4 + CA125 + ferritin, respectively. We also demonstrated that patients who had positive preoperative serum CEA, CA19-9, or CA72-4 were more likely with lymph node invasion, positive CA125 were prone to have vascular invasion, and positive CEA or CA125 were correlated with perineural invasion. In addition, positive CA19-9, CA72-4, or CA125 was associated with poorly differentiated tumor, while CEA, CA19-9, CA72-4, CA125 levels were positively correlated with pathological tumor-node-metastasis stages. We here conclude that combined serum markers can be used to not only diagnose colorectal cancer, but also appraise the tumor status for guiding treatment, evaluation of curative effect, and prognosis of patients.

Tšehhid protestisid USA raketikilbi vastu / Igor Taro

Index Scriptorium Estoniae

Taro, Igor

2007-01-01

USA soovib rajada oma ballistiliste rakettide eest kaitsva süsteemi rajatisi Poola ja Tšehhi territooriumile, mille vastu on protestinud ka Venemaa. Tšehhi Trokaveci küla elanike korraldatud referendumist ja Prahas toimunud meeleavaldustest USA raketikilbi radarijaama vastu. Lisa: USA raketikilp

Partial response to proton pump inhibitor therapy for GERD: observational study of patient characteristics, burden of disease, and costs in the USA

OpenAIRE

St?lhammar, Nils-Olov; Spiegel, Brennan M; Granstedt L?fman, Helena; Karlsson, Maria; Wahlqvist, Peter; N?sdal, J?rgen; Nelson, M Todd; Despi?gel, Nicolas

2012-01-01

Nils-Olov Stålhammar,1 Brennan M Spiegel,2,3 Helena Granstedt Löfman,1 Maria Karlsson,1 Peter Wahlqvist,1 Jørgen Næsdal,4 M Todd Nelson,5 Nicolas Despiégel61Payer Evidence, AstraZeneca R&D, Mölndal, Sweden; 2Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 3David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 4Medical Department, AstraZeneca R&D, Mölndal, Sweden; 5Late Phase...

USA's litterære superstjerne

DEFF Research Database (Denmark)

Bjerre, Thomas Ærvold

2010-01-01

Jonathan Franzen er den mest omtalte forfatter i USA lige nu og ombejlet af alle fra Time Magazine til Oprah Winfrey. Hvad er det, han kan, manden bag ”Freedom”?......Jonathan Franzen er den mest omtalte forfatter i USA lige nu og ombejlet af alle fra Time Magazine til Oprah Winfrey. Hvad er det, han kan, manden bag ”Freedom”?...

Targeting Androgen Receptor in Breast Cancer: Enzalutamide as a Novel Breast Cancer Therapeutic

Science.gov (United States)

2014-09-01

Acad Sci U S A 2011; 108: 11878-83. 5. Kabos P, Finlay-Schultz J, Li C, Kline E, Finlayson C, Wisell J, Manuel CA, Edgerton SM, Harrell JC, Elias A...Dakocytomation, Carpinteria, CA, USA), cleaved caspase 3 (Cell Signaling Technology, Danvers, MA, USA), Ki67 (sc-15402; Santa Cruz , Dallas, TX, USA) and...San Francisco, CA USA), glyceraldehyde 3-phosphate dehydrogenase (1:20,000 dilution; Sigma, St. Louis, MO USA), Topo 1 (C-21, 1:100 dilution; Santa Cruz

Ca(2+-dependent regulation of the Ca(2+ concentration in the myometrium mitochondria. II. Ca(2+ effects on mitochondria membranes polarization and [Ca(2+](m

Directory of Open Access Journals (Sweden)

L. G. Babich

2017-06-01

Full Text Available It is known that Ca2+ accumulation in the mitochondria undergoes complex regulation by Ca2+ itself. But the mechanisms of such regulation are still discussed. In this paper we have shown that Ca ions directly or indirectly regulate the level of myometrium mitochondria membranes polarization. The additions of 100 µM Ca2+ were accompanied by depolarization of the mitochondria membranes. The following experiments were designed to study the impact of Ca2+ on the myometrium mitochondria [Ca2+]m. Isolated myometrium mitochondria were preincubated without or with 10 μM Са2+ followed by 100 μM Са2+ addition. Experiments were conducted in three mediums: without ATP and Mg2+ (0-medium, in the presence of 3 mM Mg2+ (Mg-medium and 3 mM Mg2+ + 3 mM ATP (Mg,ATP-medium. It was shown that the effects of 10 μM Са2+ addition were different in different mediums, namely in 0- and Mg-medium the [Ca2+]m values increased, whereas in Mg,ATP-medium statistically reliable changes were not registered. Preincubation of mitochondria with 10 μM Са2+ did not affect the [Ca2+]m value after the addition of 100 μM Са2+. The [Ca2+]m values after 100 μM Са2+ addition were the same in 0- and Mg,ATP-mediums and somewhat lower in Mg-medium. Preliminary incubation of mitochondria with 10 μM Са2+ in 0- and Mg-mediums reduced changes of Fluo 4 normalized fluorescence values that were induced by 100 μM Са2+ additions, but in Mg,ATP-medium such differences were not recorded. It is concluded that Са2+ exchange in myometrium mitochondria is regulated by the concentration of Ca ions as in the external medium, so in the matrix of mitochondria. The medium composition had a significant impact on the [Са2+]m values in the absence of exogenous cation. It is suggested that light increase of [Са2+]m before the addition of 100 μM Са2+ may have a positive effect on the functional activity of the mitochondria.

Study of 40Ca-40Ca elastic scattering at intermediate energy

International Nuclear Information System (INIS)

Kumar, Ashok; Srivastava, B.B.

1980-01-01

The differential cross sections for 40 Ca- 40 Ca elastic scattering have been calculated at laboratory incident energy of 240 MeV using a sharp cut off of the partial waves below a critical angular momentum, 1sub(c)' to account for absorption. The effective 40 Ca- 40 Ca potential is taken to be the sum of a real nuclear potential and the Coulomb potential. The calculated differential cross sections which are in fair agreement with the experimental data are presented and discussed. (author)

INTRACELLULAR Ca2+ HOMEOSTASIS

Directory of Open Access Journals (Sweden)

Shahdevi Nandar Kurniawan

2015-01-01

Full Text Available Ca2+ signaling functions to regulate many cellular processes. Dynamics of Ca2+ signaling or homeostasis is regulated by the interaction between ON and OFF reactions that control Ca2+ flux in both the plasma membrane and internal organelles such as the endoplasmic reticulum (ER and mitochondria. External stimuli activate the ON reactions, which include Ca2+ into the cytoplasm either through channels in the plasma membrane or from internal storage like in ER. Most of the cells utilize both channels/sources, butthere area few cells using an external or internal source to control certain processes. Most of the Ca2+ entering the cytoplasm adsorbed to the buffer, while a smaller part activate effect or to stimulate cellular processes. Reaction OFF is pumping of cytoplasmic Ca2+ using a combination mechanism of mitochondrial and others. Changes in Ca2+ signal has been detected in various tissues isolated from animals induced into diabetes as well as patients with diabetes. Ca2+ signal interference is also found in sensory neurons of experimental animals with diabetes. Ca2+ signaling is one of the main signaling systems in the cell.

Etteheide: USA okupeerib Haitit / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2010-01-01

Prantsusmaa ja Brasiilia on esitanud protesti, sest USA sõjalennukitele on antud eelisõigus Haiti pealinna Port-au-Prince'i lennujaama kasutamisel. Paljude kommentaatorite hinnangul on Prantsusmaa püüdnud haarata prominentset rolli Haiti abistamisel, kuid USA on tegutsenud kiiremini ja jõulisemalt. Kaart

F-actin-based Ca signaling-a critical comparison with the current concept of Ca signaling.

Science.gov (United States)

Lange, Klaus; Gartzke, Joachim

2006-11-01

A short comparative survey on the current idea of Ca signaling and the alternative concept of F-actin-based Ca signaling is given. The two hypotheses differ in one central aspect, the mechanism of Ca storage. The current theory rests on the assumption of Ca-accumulating endoplasmic/sarcoplasmic reticulum-derived vesicles equipped with an ATP-dependent Ca pump and IP3- or ryanodine-sensitive channel-receptors for Ca-release. The alternative hypothesis proceeds from the idea of Ca storage at the high-affinity binding sites of actin filaments. Cellular sites of F-actin-based Ca storage are microvilli and the submembrane cytoskeleton. Several specific features of Ca signaling such as store-channel coupling, quantal Ca release, spiking and oscillations, biphasic and "phasic" uptake kinetics, and Ca-induced Ca release (CICR), which are not adequately described by the current concept, are inherent properties of the F-actin system and its dynamic state of treadmilling. Copyright 2006 Wiley-Liss, Inc.

MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ

International Nuclear Information System (INIS)

Cha, Min-Ji; Jang, Jin-Kyung; Ham, Onju; Song, Byeong-Wook; Lee, Se-Yeon; Lee, Chang Yeon; Park, Jun-Hee; Lee, Jiyun; Seo, Hyang-Hee; Choi, Eunhyun; Jeon, Woo-min; Hwang, Hye Jin; Shin, Hyun-Taek

2013-01-01

Highlights: •CaMKIIδ mediates H 2 O 2 -induced Ca 2+ overload in cardiomyocytes. •miR-145 can inhibit Ca 2+ overload. •A luciferase assay confirms that miR-145 functions as a CaMKIIδ-targeting miRNA. •Overexpression of miR-145 regulates CaMKIIδ-related genes and ameliorates apoptosis. -- Abstract: A change in intracellular free calcium (Ca 2+ ) is a common signaling mechanism of reperfusion-induced cardiomyocyte death. Calcium/calmodulin dependent protein kinase II (CaMKII) is a critical regulator of Ca 2+ signaling and mediates signaling pathways responsible for functions in the heart including hypertrophy, apoptosis, arrhythmia, and heart disease. MicroRNAs (miRNA) are involved in the regulation of cell response, including survival, proliferation, apoptosis, and development. However, the roles of miRNAs in Ca 2+ -mediated apoptosis of cardiomyocytes are uncertain. Here, we determined the potential role of miRNA in the regulation of CaMKII dependent apoptosis and explored its underlying mechanism. To determine the potential roles of miRNAs in H 2 O 2 -mediated Ca 2+ overload, we selected and tested 6 putative miRNAs that targeted CaMKIIδ, and showed that miR-145 represses CaMKIIδ protein expression and Ca 2+ overload. We confirmed CaMKIIδ as a direct downstream target of miR-145. Furthermore, miR-145 regulates Ca 2+ -related signals and ameliorates apoptosis. This study demonstrates that miR-145 regulates reactive oxygen species (ROS)-induced Ca 2+ overload in cardiomyocytes. Thus, miR-145 affects ROS-mediated gene regulation and cellular injury responses

Ideaalne torm USA majanduses / Ken Goldstein ; interv. Neeme Raud

Index Scriptorium Estoniae

Goldstein, Ken

2008-01-01

USA majandusuuringute organisatsiooni The Conference Board analüütik USA majanduse olukorrast, mõjust maailmamajandusele, arenguvõimalustest ning uue presidendi vajalikest sammudest majanduses. Lisa: Enamuse arvates on USA valel teel

Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-α and TSGF after cryosurgery in pancreatic cancer patients.

Science.gov (United States)

Zhou, Gang; Niu, Lizhi; Chiu, David; He, Lihua; Xu, Kecheng

2012-07-01

The presence of serum tumor markers, carbohydrate antigen 242 (CA242), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), tumor-supplied group of factors (TSGF) and tumor necrosis factor-α (TNF-α), is closely associated with invasion and metastasis of many malignancies. The expression of these markers were measured in serum taken from 37 pancreatic cancer patients prior to treatment. Levels of CA242, CA199, CA125, CEA and TNF-α expression correlated with tumor size, clinical stage, tumor differentiation, lymph node and liver metastasis (P markers were significantly reduced compared with levels prior to cryosurgery (P 0.05). Thus, cryosurgery is more effective than chemotherapy for decreasing CA242, CA199, CA125, CEA, TSGF and TNF-α serum levels in these patients.

Regulated release of Ca2+ from respiring mitochondria by Ca2+/2H+ antiport.

Science.gov (United States)

Fiskum, G; Lehninger, A L

1979-07-25

Simultaneous measurements of oxygen consumption and transmembrane transport of Ca2+, H+, and phosphate show that the efflux of Ca2+ from respiring tightly coupled rat liver mitochondria takes place by an electroneutral Ca2+/2H+ antiport process that is ruthenium red-insensitive and that is regulated by the oxidation-reduction state of the mitochondrial pyridine nucleotides. When mitochondrial pyridine nucleotides are kept in a reduced steady state, the efflux of Ca2+ is inhibited; when they are in an oxidized state, Ca2+ efflux is activated. These processes were demonstrated by allowing phosphate-depleted mitochondria respiring on succinate in the presence of rotenone to take up Ca2+ from the medium. Upon subsequent addition of ruthenium red to block Ca2+ transport via the electrophoretic influx pathway, and acetoacetate, to bring mitochondrial pyridine nucleotides into the oxidized state, Ca2+ efflux and H+ influx ensued. The observed H+ influx/Ca2+ efflux ratio was close to the value 2.0 predicted for the operation of an electrically neutral Ca2+/2H+ antiport process.

The role of Ca(2+) mediated signaling pathways on the effect of taurine against Streptococcus uberis infection.

Science.gov (United States)

Dai, Bin; Zhang, Jinqiu; Liu, Ming; Lu, Jinye; Zhang, Yuanshu; Xu, Yuanyuan; Miao, Jinfeng; Yin, Yulong

2016-08-30

To provide insight into the mechanisms of taurine attenuation of pro-inflammatory response in mouse mammary epithelial cell line (EpH4-Ev, purchased by ATCC, USA) after Streptococcus uberis (S. uberis, 0140J) challenge, we infected MECs with S. uberis (2.5×10(7)cfumL(-1), MOI=10) for 3h and quantified changes in TLR-2 and calcium (Ca(2+)) mediated signaling pathways. The results indicate that S. uberis infection significantly increases the expression of TLR-2, intracellular Ca(2+) levels, PLC-γ1 and PKC-α, the activities of transcription factors NF-κB and NFAT, and related cytokines (TNF-α, IL-1β, IL-6, G-CSF, IL-2, KC, IL-15, FasL, MCP-1, and LIX) in culture supernatants. Taurine administration downregulated all these indices, the activities of NF-κB and NFAT. Cytokine secretions were similar using special PKC inhibitor Go 6983 and NFAT inhibitor VIVIT. Our data indicate that S. uberis infection induces pro-inflammatory response of MECs through a TLR-2 mediated signaling pathway. In addition, taurine can prevent MEC damage by affecting both PLC-γ1-Ca(2+)-PKC-α-NF-κB and PLC-γ1-Ca(2+)-NFATs signaling pathways. This is the first report to demonstrate the mechanisms of taurine attenuated pro-inflammatory response in MECs after S. uberis challenge. Copyright © 2016 Elsevier B.V. All rights reserved.

Applicative Value of Serum CA19-9, CEA, CA125 and CA242 in Diagnosis and Prognosis for Patients with Pancreatic Cancer Treated by Concurrent Chemoradiotherapy.

Science.gov (United States)

Gu, Yu-Lei; Lan, Chao; Pei, Hui; Yang, Shuang-Ning; Liu, Yan-Fen; Xiao, Li-Li

2015-01-01

To evaluate the application value of serum CA19-9, CEA, CA125 and CA242 in diagnosis and prognosis of pancreatic cancer cases treated with concurrent chemotherapy. 52 patients with pancreatic cancer, 40 with benign pancreatic diseases and 40 healthy people were selected. The electrochemiluminescence immunoassay method was used for detecting levels of CA19-9, CEA and CA125, and a CanAg CA242 enzyme linked immunoassay kit for assessing the level of CA242. The Kaplan-Meier method was used for analyzing the prognostic factors of patients with pancreatic cancer. The Cox proportional hazard model was applied for analyzing the hazard ratio (HR) and 95% confidential interval (CI) for survival time of patients with pancreatic cancer. The levels of serum CA19-9, CEA, CA125 and CA242 in patients with pancreatic cancer were significantly higher than those in patients with benign pancreatic diseases and healthy people (PCEA. The specificity of CA242 is the highest, followed by CA125, CEA and CA19-9. The sensitivity and specificity of joint detection of serum CA19-9, CEA, CA125and CA242 were 90.4% and 93.8%, obviously higher than single detection of those markers in diagnosis of pancreatic cancer. The median survival time of 52 patients with pancreatic cancer was 10 months (95% CI7.389~12.611).. Patients with the increasing level of serum CA19-9, CEA, CA125, CA242 had shorter survival times (P=0.047. 0.043, 0.0041, 0.029). COX regression analysis showed that CA19-9 was an independent prognostic factor for patients with pancreatic cancer (P=0.001, 95%CI 2.591~38.243). The detection of serum tumor markers (CA19.9, CEA, CA125 and CA242) is conducive to the early diagnosis of pancreatic cancer and joint detection of tumor markers helps improve the diagnostic efficiency. Moreover, CA19-9 is an independent prognostic factor for patients with pancreatic cancer.

Ilves kritiseeris USA juhtidega Venemaad / Dagne Hanschmidt

Index Scriptorium Estoniae

Hanschmidt, Dagne

2008-01-01

Ilmunud ka: Postimees : na russkom jazõke 21. apr. lk. 4. President Toomas Hendrik Ilves kohtus töövisiidil Ameerika Ühendriikidesse USA asepresidendi Dick Cheney ja riigisekretär Condoleezza Rice'iga. Arutusel olid Euroopa Liidu suhted Venemaaga, Venemaa käitumine Gruusiaga, NATO viimase tippkohtumise tulemused. USA välisminister C. Rice avaldas Eesti presidendile tänu Eesti silmapaistva panuse eest Afganistanis. Kohtumisi kommenteerivad Riigikogu Euroopa Liidu asjade komisjoni esimees Marko Mihkelson ja Riigikogu väliskomisjoni esimees Sven Mikser. Vt. samas: Euroliit andis USA viisavabadusele rohelise tee. Euroopa Liidu sise- ja justiitsministrite kohtumisel kiideti heaks otsused, mis võimaldavad Eestil liituda USA viisavabadusprogrammiga. Vabariigi President töövisiidil Ameerika Ühendriikides 17.-23.04.2008

77 FR 27082 - StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc., 1250 H Street, Greeley, CO...

Science.gov (United States)

2012-05-08

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,850; TA-W-74,850A] StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc., 1250 H Street, Greeley, CO; Amended... workers and former workers of StarTek USA, Inc., Greeley, Colorado. The Department's notice of...

Võidurelvastumise tagasitulek : USA kiiluvees Venemaa ja Hiina / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2007-01-01

USA eelarvekavas on ette nähtud kaitsekulutuste jätkuv suurenemine, suureneda võib ka relvajõudude isikkoosseis. Relvajõududele kulub USA-s ligi 4% SKT-st. Globaalselt liidetuna tõusid kõikide riikide kulutused relvajõududele 1990. aasta tasemele. Hiina ja Venemaa kaitsekulutustest. Lisad: Aasia riigid kasvatavad sõjalisi kulutusi; 25 riigil pole oma sõjaväge. Graafik: USA sõjalised kulutused

USA National Phenology Network observational data documentation

Science.gov (United States)

Rosemartin, Alyssa H.; Denny, Ellen G.; Gerst, Katharine L.; Marsh, R. Lee; Posthumus, Erin E.; Crimmins, Theresa M.; Weltzin, Jake F.

2018-04-25

The goals of the USA National Phenology Network (USA-NPN, www.usanpn.org) are to advance science, inform decisions, and communicate and connect with the public regarding phenology and species’ responses to environmental variation and climate change. The USA-NPN seeks to advance the science of phenology and facilitate ecosystem stewardship by providing phenological information freely and openly. To accomplish these goals, the USA-NPN National Coordinating Office (NCO) delivers observational data on plant and animal phenology in several formats, including minimally processed status and intensity datasets and derived phenometrics for individual plants, sites, and regions. This document describes the suite of observational data products delivered by the USA National Phenology Network, covering the period 2009–present for the United States and accessible via the Phenology Observation Portal (http://dx.doi.org/10.5066/F78S4N1V) and via an Application Programming Interface. The data described here have been used in diverse research and management applications, including over 30 publications in fields such as remote sensing, plant evolution, and resource management.

Comparative kinetics of sup 47 Ca, sup 85 Sr and sup 226 Ra in the freshwater turtle, Trachemys scripta

Energy Technology Data Exchange (ETDEWEB)

Hinton, T.G. (Savannah River Ecology Lab., Aiken, SC (United States) Colorado State Univ., Fort Collins, CO (United States)); Whicker, F.W.; Ibrahim, S.A. (Colorado State Univ., Fort Collins, CO (United States)); Pinder, J.E. III (Savannah River Ecology Lab., Aiken, SC (United States))

1992-01-01

The kinetics of {sup 47}Ca, {sup 85}Sr and {sup 226}Ra were compared in the yellow-bellied slider, a common freshwater turtle of the southeastern USA. The absorption and elimination processes were examined as a function of stable dietary Ca, season, age and sex of the animals. Turtles were gavaged with radionuclides and serial whole-body analyses were performed on the live animals for up to 480 days. Only in the juvenile age class did reduced dietary Ca cause a significant increase in {sup 85}Sr absorption. The absorption of {sup 85}Sr and {sup 226}Ra in the adult male, adult female and hatchling groups was unaffected by dietary Ca. Mean absorption was greater than that which has been reported for other organisms and significantly differed among isotopes. The high absorption values were not restricted to immatures, but continued into maturity. Elimination rates were not affected by the dietary treatment, nor were isotopic differences in elimination observed. Annual mean elimination rate constants pooled among animal groups, were 0.22 {+-} 0.07 for {sup 85}Sr and 0.26 {+-} 0.18 for {sup 226}Ra. Retention was strongly affected by season with the greatest elimination occurring in the summer and declining to levels that were not distinguishable from zero in the winter. Elimination rate constants for hatchlings were greater than for the other age groups. (author).

USA kunstidessant Venemaale

Index Scriptorium Estoniae

2007-01-01

USA kunstnike näitus "Kolm sajandit ameerika kunsti" Moskvas Pushkini muuseumis. Eksponeeritakse Mark Rothko, Jean-Michel Basguiat', Roy Lichtensteini, Robert Rauschenbergi, Georgia O'Keefe'i, Willem de Kooningi töid

Testing the fidelity of the Sr/Ca proxy in recording ocean temperature in a western Atlantic coral

Science.gov (United States)

Kuffner, I. B.; Roberts, K.; Flannery, J. A.; Richey, J. N.; Morrison, J. M.

2017-12-01

Massive corals provide a useful archive of environmental variability, but careful testing of geochemical proxies in corals is necessary to validate the relationship between each proxy and environmental parameter throughout the full range of conditions experienced by the recording organisms. Here we use samples from a field-based coral-growth study to test the hypothesis that Sr/Ca in the coral Siderastrea siderea accurately records sea-surface temperature (SST) in the subtropics (Florida, USA) along 350 km of reef tract. We test calcification rate, measured via buoyant weight, and linear extension (LE) rate, estimated with Alizarin Red-S staining, as predictors of variance in the Sr/Ca records of 39 individual S. siderea corals grown at four outer-reef locations next to in-situ temperature loggers during two, year-long periods. We found that corals with calcification rates less than 1.7 mg cm-2 d-1 or LE rates less than 1.7 mm yr-1 returned spuriously high Sr/Ca values, leading to a cold bias in Sr/Ca-based SST estimates. The threshold-type response curves suggest that LE rate can be used as a quality-control indicator during sample and microdrill-path selection when using long cores for SST paleoreconstruction. For our corals that passed this quality control step, the Sr/Ca-SST proxy performed well in estimating mean annual SST across three sites spanning 350 km of the Florida reef tract. However, there was some evidence that extreme temperature stress in 2010 (cold snap) and 2011 (SST above coral-bleaching threshold) may have caused the corals not to record the temperature extremes. Known stress events could be avoided during modern calibrations of paleoproxies.

The CaV2.3 R-type voltage-gated Ca2+ channel in mouse sleep architecture.

Science.gov (United States)

Siwek, Magdalena Elisabeth; Müller, Ralf; Henseler, Christina; Broich, Karl; Papazoglou, Anna; Weiergräber, Marco

2014-05-01

Voltage-gated Ca(2+) channels (VGCCs) are key elements in mediating thalamocortical rhythmicity. Low-voltage activated (LVA) CaV 3 T-type Ca(2+) channels have been related to thalamic rebound burst firing and to generation of non-rapid eye movement (NREM) sleep. High-voltage activated (HVA) CaV 1 L-type Ca(2+) channels, on the opposite, favor the tonic mode of action associated with higher levels of vigilance. However, the role of the HVA Non-L-type CaV2.3 Ca(2+) channels, which are predominantly expressed in the reticular thalamic nucleus (RTN), still remains unclear. Recently, CaV2.3(-/-) mice were reported to exhibit altered spike-wave discharge (SWD)/absence seizure susceptibility supported by the observation that CaV2.3 mediated Ca(2+) influx into RTN neurons can trigger small-conductance Ca(2+)-activated K(+)-channel type 2 (SK2) currents capable of maintaining thalamic burst activity. Based on these studies we investigated the role of CaV2.3 R-type Ca(2+) channels in rodent sleep. The role of CaV2.3 Ca(2+) channels was analyzed in CaV2.3(-/-) mice and controls in both spontaneous and artificial urethane-induced sleep, using implantable video-EEG radiotelemetry. Data were analyzed for alterations in sleep architecture using sleep staging software and time-frequency analysis. CaV2.3 deficient mice exhibited reduced wake duration and increased slow-wave sleep (SWS). Whereas mean sleep stage durations remained unchanged, the total number of SWS epochs was increased in CaV2.3(-/-) mice. Additional changes were observed for sleep stage transitions and EEG amplitudes. Furthermore, urethane-induced SWS mimicked spontaneous sleep results obtained from CaV2.3 deficient mice. Quantitative Real-time PCR did not reveal changes in thalamic CaV3 T-type Ca(2+) channel expression. The detailed mechanisms of SWS increase in CaV2.3(-/-) mice remain to be determined. Low-voltage activated CaV2.3 R-type Ca(2+) channels in the thalamocortical loop and extra

Krossil on probleeme USA viisaga? / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2011-01-01

Eesti Päevaleht esitas USA Eesti-saatkonnale järelepärimise seoses sellega, et Eerik-Niiles Krossi USA-viisa on tühistatud. Saatkonna pressi- ja kultuuriatašee James Landi vastusest. Eerik-Niiles Krossi kommentaare

Rates for some reactions involving 42Ca and 44Ca

International Nuclear Information System (INIS)

Cheng, C.W.; King, J.D.

1980-01-01

Ground-state reaction rates have been deduced from recent cross section measurements for the 42 CA(α, n) 45 Ti, 42 Ca(p, γ) 43 Sc, and 44 Ca(p, n) 44 Sc reactions. Comparison of these rates with those calculated from a statistical model of nuclear reactions. (Woosley et al) shows good agreement for the first two, but the 44 Ca(p, n) rate is more than a factor of 2 less than the theoretical prediction. Stellar reaction rates have been derived from the ground-state rates by multiplying the ground-state rates by the ratio of stellar to ground-state rates given by the statistical model. Both ground-state and stellar rates have been represented by analytic functions of the temperature. The role of these reactions in the approach to quasi-equilibrium during explosive silicon burning is discussed

Mg-Ca Alloys Produced by Reduction of CaO: Understanding of ECO-Mg Alloy Production

Science.gov (United States)

Jung, In-Ho; Lee, Jin Kyu; Kim, Shae K.

2017-04-01

There have been long debates about the environment conscious (ECO) Mg technology which utilizes CaO to produce Ca-containing Mg alloys. Two key process technologies of the ECO-Mg process are the chemical reduction of CaO by liquid Mg and the maintenance of melt cleanliness during the alloying of Ca. Thermodynamic calculations using FactSage software were performed to explain these two key issues. In addition, an experimental study was performed to compare the melt cleanliness of the Ca-containing Mg alloys produced by the conventional route with metallic Ca and the ECO-Mg route with CaO.

Poola ootab USA maaväelasi

Index Scriptorium Estoniae

2014-01-01

Poola kaitseministri Tomasz Siemoniaki sõnul saadab USA Poolasse maavägesid, et laeindada NATO kohalolekut ajal, mil pingeline olukord Ukrainas kestab, kirjutas Washington Post. Siemoniak ütles lehele, et sõjalised planeerijad juba töötavad vastava kava üksikasjade kallal. Ta lisas, et tõenäoliselt saadetakse USA sõdureid ka Baltimaadesse

The study of skeletal calcium metabolism with 41Ca and 45Ca

Science.gov (United States)

Freeman, Stewart P. H. T.; Beck, Belinda; Bierman, June M.; Caffee, Marc W.; Heaney, Robert P.; Holloway, Leah; Marcus, Robert; Southon, John R.; Vogel, John S.

2000-10-01

The living skeleton can be labeled for life by the administration of radiologically trivial amounts of 41Ca tracer. After initial elimination of tracer from the readily exchangeable calcium pools subsequent skeletal calcium turnover maintains and modulates the urine 41Ca content. Uniquely, bone calcium metabolism may then be studied with tracer in near equilibrium with the body's calcium and resorbing calcium directly measured by accelerator mass spectrometry (AMS) of excreta. Our experiments with 25 41Ca labeled subjects demonstrate excellent diurnal stability and remarkable response to intervention of the urine signal. Thus the tracer method may prove a competitive means of measuring the effects of antiresorptive osteoporosis treatments, for therapy development or even clinical monitoring. Novel studies of long-term skeletal evolution are also possible. We realize that routinely administered short-lived calcium radiotracers contain 41Ca impurities and that thousands of experimental participants have been historically inadvertently 41Ca labeled. The 41Ca urine index might now rapidly further be characterized by contemporary measurements of these one-time subjects, and with their by now thoroughly skeleton-equilibrated tracer they might be ideal participants in other new experiments. We are also investigating 45Ca AMS. It may prove preferable to label the skeleton with this radiotracer already familiar to bioscientists, but new to AMS.

USA relvastab araabia maid miljardite dollaritega / Kunnar Kukk

Index Scriptorium Estoniae

Kukk, Kunnar

2007-01-01

USA välisminister Condoleezza Rice ja kaitseminister Robert Gates tegid visiidi Saudi-Araabiasse. Arvatakse, et nad on pehmendamas katastroofi, mis järgneks USA vägede järk-järgulisele taandumisele Iraagist. USA kavatseb anda Pärsia riikidele sõjalist abi, et tuua Iraan kolmepoolsetele läbirääkimistele. Lisa: Kodusõda võib olla vältimatu

USA tunnistab valge fosfori relvana kasutamist Iraagis / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2005-01-01

Kui varem USA eitas valge fosfori kasutamist Iraagis Falluja linnas, siis nüüd on ta eitamisest loobunud. USA välisministeeriumi pressiteate kohaselt ei kasutatud fosforit keemiarelvana. Sütitavate relvade kasutamine tsiviilisikute vastu on keelatud. Vt. samas: Ahto Lobjakas. Europarlamendis USA hukkamõist

Blair üritab muuta USA Euroopa-meelsemaks / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2004-01-01

USA presidendi George W. Bushi ja Suurbritannia peaministri Tony Blairi kohtumine Valges Majas. Blairi parteikaaslase Helen Jacksoni kriitika Blairi USA-poliitika kohta. Suurbritannia endise välisministri Robin Cooki sõnul on USA ja Euroopa poliitilised väärtushinnangud pigem lahknemas kui ühtimas

USA raport hoiatab tuumaterroristide eest / Karin Volmer

Index Scriptorium Estoniae

Volmer, Karin

2007-01-01

USA-s tegutseva tuumaterrori vastase organisatsiooni Nuclear Threat Initiative (NTI) raport kinnitab maailma edusamme tuumamaterjali turvalisuses, kuid on ka palju ohuallikaid. Analüütikud kahtlevad Venemaa ja Pakistani armee usaldusväärsuses tuumamaterjali hoidmisel. Lisa: Tuumaterrori raport

MicroRNA-145 suppresses ROS-induced Ca{sup 2+} overload of cardiomyocytes by targeting CaMKIIδ

Energy Technology Data Exchange (ETDEWEB)

Cha, Min-Ji [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Jang, Jin-Kyung [College of Pharmacy, Sookmyung Women’s University, 52 HyoChangWon-Gil, Yongsan-ku, Seoul 140-742 (Korea, Republic of); Ham, Onju; Song, Byeong-Wook; Lee, Se-Yeon [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Lee, Chang Yeon; Park, Jun-Hee [Department of Integrated Omics for Biomedical Sciences, Graduate School, Yonsei University, 50 Yonsei-ro, Seodamun-gu, Seoul 120-759 (Korea, Republic of); Lee, Jiyun; Seo, Hyang-Hee [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Choi, Eunhyun [Severance Integrative Research Institute for Cerebral and Cardiovascular Disease, Yonsei University Health System, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Jeon, Woo-min [Department of Animal Resource, Sahmyook University, Seoul 139-742 (Korea, Republic of); Hwang, Hye Jin [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Shin, Hyun-Taek [College of Pharmacy, Sookmyung Women’s University, 52 HyoChangWon-Gil, Yongsan-ku, Seoul 140-742 (Korea, Republic of); and others

2013-06-14

Highlights: •CaMKIIδ mediates H{sub 2}O{sub 2}-induced Ca{sup 2+} overload in cardiomyocytes. •miR-145 can inhibit Ca{sup 2+} overload. •A luciferase assay confirms that miR-145 functions as a CaMKIIδ-targeting miRNA. •Overexpression of miR-145 regulates CaMKIIδ-related genes and ameliorates apoptosis. -- Abstract: A change in intracellular free calcium (Ca{sup 2+}) is a common signaling mechanism of reperfusion-induced cardiomyocyte death. Calcium/calmodulin dependent protein kinase II (CaMKII) is a critical regulator of Ca{sup 2+} signaling and mediates signaling pathways responsible for functions in the heart including hypertrophy, apoptosis, arrhythmia, and heart disease. MicroRNAs (miRNA) are involved in the regulation of cell response, including survival, proliferation, apoptosis, and development. However, the roles of miRNAs in Ca{sup 2+}-mediated apoptosis of cardiomyocytes are uncertain. Here, we determined the potential role of miRNA in the regulation of CaMKII dependent apoptosis and explored its underlying mechanism. To determine the potential roles of miRNAs in H{sub 2}O{sub 2}-mediated Ca{sup 2+} overload, we selected and tested 6 putative miRNAs that targeted CaMKIIδ, and showed that miR-145 represses CaMKIIδ protein expression and Ca{sup 2+} overload. We confirmed CaMKIIδ as a direct downstream target of miR-145. Furthermore, miR-145 regulates Ca{sup 2+}-related signals and ameliorates apoptosis. This study demonstrates that miR-145 regulates reactive oxygen species (ROS)-induced Ca{sup 2+} overload in cardiomyocytes. Thus, miR-145 affects ROS-mediated gene regulation and cellular injury responses.

Structural, electronic, elastic, and thermodynamic properties of CaSi, Ca2Si, and CaSi2 phases from first-principles calculations

Science.gov (United States)

Li, X. D.; Li, K.; Wei, C. H.; Han, W. D.; Zhou, N. G.

2018-06-01

The structural, electronic, elastic, and thermodynamic properties of CaSi, Ca2Si, and CaSi2 are systematically investigated by using first-principles calculations method based on density functional theory (DFT). The calculated formation enthalpies and cohesive energies show that CaSi2 possesses the greatest structural stability and CaSi has the strongest alloying ability. The structural stability of the three phases is compared according to electronic structures. Further analysis on electronic structures indicates that the bonding of these phases exhibits the combinations of metallic, covalent, and ionic bonds. The elastic constants are calculated, and the bulk modulus, shear modulus, Young's modulus, Poisson's ratio, and anisotropy factor of polycrystalline materials are deduced. Additionally, the thermodynamic properties were theoretically predicted and discussed.

Accessing the nuclear symmetry energy in Ca+Ca collisions

Directory of Open Access Journals (Sweden)

Chbihi A.

2012-07-01

Full Text Available The status of the analysis of the INDRA-VAMOS experiement performed at GANIL, using the reactions 40,48Ca+40,48Ca reactions at 35AMeV, are presented. Isotopic distributions of fragments produced in multifragmentation events provide information on the importance of the surface term contribution in the symmetry energy by comparison to AMD predictions.

USA ja EL vähendavad kaubandustõkkeid / Kertu Ruus

Index Scriptorium Estoniae

Ruus, Kertu, 1977-

2005-01-01

Tippkohtumisel Washingtonis arutasid Euroopa Komisjoni president Jose Manuel Barroso ja USA president George W. Bush, kuidas EL-i ja USA majandussuhteid vabamaks muuta. Diagramm: EL-i kaubavahetus USA-ga

First report in South America of companion animal colonization by the USA1100 clone of community-acquired meticillin-resistant Staphylococcus aureus (ST30) and by the European clone of methicillin-resistant Staphylococcus pseudintermedius (ST71).

Science.gov (United States)

Quitoco, Isidório Mebinda Zuco; Ramundo, Mariana Severo; Silva-Carvalho, Maria Cícera; Souza, Raquel Rodrigues; Beltrame, Cristiana Ossaille; de Oliveira, Táya Figueiredo; Araújo, Rodrigo; Del Peloso, Pedro Fernandez; Coelho, Leonardo Rocchetto; Figueiredo, Agnes Marie Sá

2013-08-27

Methicillin-resistant staphylococci can colonize and cause diseases in companion animals. Unfortunately, few molecular studies have been carried out in Brazil and other countries with the aim of characterizing these isolates. Consequently, little is known about the potential role of companion animals in transmitting these resistant bacteria to humans. In this work we searched for mecA gene among Staphylococcus isolates obtained from nasal microbiota of 130 healthy dogs and cats attended in a veterinary clinic located in the west region of Rio de Janeiro. The isolates recovered were identified to the species level and characterized using molecular tools. A community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolate related to USA1100 (Southwest Pacific clone) and susceptible to all non-β-lactams was detected in a cat (1.7%, 1/60). Another coagulase-positive isolate harboring mecA was recovered from a dog (1.4%, 1/70) and identified as Staphylococcus pseudintermedius (MRSP) related to the European clone (ST71). The two isolates of Staphylococcus conhii subsp. urealyticus (1.4%, 1/70 dogs and 1.7%, 1/60 cats), similarly to the MRSP isolate, also presented high-level multiresistance. The majority of the methicillin-resistant coagulase-negative staphylococci recovered were Staphylococcus saprophyticus (5.7%, 4/70 dogs and 6.7%, 4/60 cats) and all clustered into the same PFGE type. This work demonstrates that mecA-harboring Staphylococcus isolates are common members of the nasal microbiota of the healthy companion animals studied (9.2%, 12/130 animals), including some high-level multiresistant isolates of S. pseudintermedius and S. conhii subsp. urealyticus. The detection, for the first time in South America, of USA1100-related CA-MRSA and of ST71 MRSP (European clone), colonizing companion animals, is of concern. Both S. pseudintermedius and S. aureus are important agents of infections for animals. The USA1100 CA-MRSA is a causative of severe and

Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis.

Directory of Open Access Journals (Sweden)

Xiao-Chen Li

Full Text Available Heart tissues from hibernating mammals, such as ground squirrels, are able to endure hypothermia, hypoxia and other extreme insulting factors that are fatal for human and nonhibernating mammals. This study was designed to understand adaptive mechanisms involved in intracellular Ca(2+ homeostasis in cardiomyocytes from the mammalian hibernator, ground squirrel, compared to rat. Electrophysiological and confocal imaging experiments showed that the voltage-dependence of L-type Ca(2+ current (I(Ca was shifted to higher potentials in ventricular myocytes from ground squirrels vs. rats. The elevated threshold of I(Ca did not compromise the Ca(2+-induced Ca(2+ release, because a higher depolarization rate and a longer duration of action potential compensated the voltage shift of I(Ca. Both the caffeine-sensitive and caffeine-resistant components of cytosolic Ca(2+ removal were more rapid in ground squirrels. Ca(2+ sparks in ground squirrels exhibited larger amplitude/size and much lower frequency than in rats. Due to the high I(Ca threshold, low SR Ca(2+ leak and rapid cytosolic Ca(2+ clearance, heart cells from ground squirrels exhibited better capability in maintaining intracellular Ca(2+ homeostasis than those from rats and other nonhibernating mammals. These findings not only reveal adaptive mechanisms of hibernation, but also provide novel strategies against Ca(2+ overload-related heart diseases.

76 FR 35715 - Establishment of the SelectUSA Initiative

Science.gov (United States)

2011-06-20

... Establishment of the SelectUSA Initiative By the authority vested in me as President by the Constitution and the... unnecessary obstacles to investment. Sec. 2. SelectUSA Initiative. (a) Establishment. There is established the SelectUSA Initiative (Initiative), a Government-wide initiative to attract and retain investment in the...

The environment as an unrecognized reservoir for community-associated methicillin resistant Staphylococcus aureus USA300: a case-control study.

Directory of Open Access Journals (Sweden)

Anne-Catrin Uhlemann

Full Text Available BACKGROUND: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA infections are spreading, but the source of infections in non-epidemic settings remains poorly defined. METHODS: We carried out a community-based, case-control study investigating socio-demographic risk factors and infectious reservoirs associated with MRSA infections. Case patients presented with CA-MRSA infections to a New York hospital. Age-matched controls without infections were randomly selected from the hospital's Dental Clinic patient population. During a home visit, case and control subjects completed a questionnaire, nasal swabs were collected from index respondents and household members and standardized environmental surfaces were swabbed. Genotyping was performed on S. aureus isolates. RESULTS: We enrolled 95 case and 95 control subjects. Cases more frequently reported diabetes mellitus and a higher number of skin infections among household members. Among case households, 53 (56% were environmentally contaminated with S. aureus, compared to 36 (38% control households (p = .02. MRSA was detected on fomites in 30 (32% case households and 5 (5%; p<.001 control households. More case patients, 20 (21% were nasally colonized with MRSA than were control indexes, 2 (2%; p<.001. In a subgroup analysis, the clinical isolate (predominantly USA300, was more commonly detected on environmental surfaces in case households with recurrent MRSA infections (16/36, 44% than those without (14/58, 24%, p = .04. CONCLUSIONS: The higher frequency of environmental contamination of case households with S. aureus in general and MRSA in particular implicates this as a potential reservoir for recolonization and increased risk of infection. Environmental colonization may contribute to the community spread of epidemic strains such as USA300.

Riskiäri USA kõrbes / Tarmo Vahter, Sulev Vedler

Index Scriptorium Estoniae

Vahter, Tarmo, 1970-

2011-01-01

Eesti Energia ostis USA kõrbes mahajäetud kaevanduse koos põlevkivivaruga, millest Brasiilia naftagigant Petrobras ja Jaapani suurfirma Mitsui ja Co loobusid. Eesti Energia põlevkiviprojektist USA-s

Mg and Ca isotope fractionation during CaCO3 biomineralisation

International Nuclear Information System (INIS)

Chang, Veronica T.-C.; Williams, R.J.P.; Makishima, Akio; Belshawl, Nick S.; O'Nions, R. Keith

2004-01-01

The natural variation of Mg and Ca stable isotopes of carbonates has been determined in carbonate skeletons of perforate foraminifera and reef coral together with Mg/Ca ratios to assess the influence of biomineralisation processes. The results for coral aragonite suggest its formation, in terms of stable isotope behaviour, approximates to inorganic precipitation from a seawater reservoir. In contrast, results for foraminifera calcite suggest a marked biological control on Mg isotope ratios presumably related to its low Mg content compared with seawater. The bearing of these observations on the use of Mg and Ca isotopes as proxies in paleoceanography is considered

Effects of Ca on microstructure, mechanical and corrosion properties and biocompatibility of Mg-Zn-Ca alloys.

Science.gov (United States)

Yin, Ping; Li, Nian Feng; Lei, Ting; Liu, Lin; Ouyang, Chun

2013-06-01

Zn and Ca were selected as alloying elements to develop an Mg-Zn-Ca alloy system for biomedical application due to their good biocompatibility. The effects of Ca on the microstructure, mechanical and corrosion properties as well as the biocompatibility of the as-cast Mg-Zn-Ca alloys were studied. Results indicate that the microstructure of Mg-Zn-Ca alloys typically consists of primary α-Mg matrix and Ca₂Mg₆Zn₃/Mg₂Ca intermetallic phase mainly distributed along grain boundary. The yield strength of Mg-Zn-Ca alloy increased slightly with the increase of Ca content, whilst its tensile strength increased at first and then decreased. Corrosion tests in the simulated body fluid revealed that the addition of Ca is detrimental to corrosion resistance due to the micro-galvanic corrosion acceleration. In vitro hemolysis and cytotoxicity assessment disclose that Mg-5Zn-1.0Ca alloy has suitable biocompatibility.

The diagnostic value of serum tumor markers CEA, CA19-9, CA125, CA15-3, and TPS in metastatic breast cancer.

Science.gov (United States)

Wang, Weigang; Xu, Xiaoqin; Tian, Baoguo; Wang, Yan; Du, Lili; Sun, Ting; Shi, Yanchun; Zhao, Xianwen; Jing, Jiexian

2017-07-01

This study aims to understand the diagnostic value of serum tumor markers carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9), cancer antigen 125 (CA125), cancer antigen 15-3 (CA15-3), and tissue polypeptide-specific antigen (TPS) in metastatic breast cancer (MBC). A total of 164 metastatic breast cancer patients in Shanxi Cancer Hospital were recruited between February 2016 and July 2016. 200 breast cancer patients without metastasis in the same period were randomly selected as the control group. The general characteristics, immunohistochemical, and pathological results were investigated between the two groups, and tumor markers were determined. There were statistical differences in the concentration and the positive rates of CEA, CA19-9, CA125, CA15-3, and TPS between the MBC and control group (Ptumor marker at 56.7% and 97.0%, respectively. In addition, two tumor markers were used for the diagnosis of MBC and the CEA and TPS combination had the highest diagnostic sensitivity with 78.7%, while the CA15-3 and CA125 combination had the highest specificity of 91.5%. Analysis of tumor markers of 164 MBC found that there were statistical differences in the positive rates of CEA and CA15-3 between bone metastases and other metastases (χ 2 =6.00, P=0.014; χ 2 =7.32, P=0.007, respectively). The sensitivity and specificity values of the CEA and CA15-3 combination in the diagnosis of bone metastases were 77.1% and 45.8%, respectively. The positive rate of TPS in the lung metastases group was lower than in other metastases (χ 2 =8.06, P=0.005).There were significant differences in the positive rates of CA15-3 and TPS between liver metastases and other metastases (χ 2 =15.42, Ptumor markers have varying diagnostic value. Copyright © 2017 Elsevier B.V. All rights reserved.

New limits on 2β processes in 40Ca and 46Ca by using low radioactive CaF2(Eu) crystal scintillators

International Nuclear Information System (INIS)

Belli, P.; Bernabei, R.; Dai, C.J.

2001-01-01

The development of highly radiopure CaF 2 (Eu) crystal scintillators has been performed aiming at a substantial sensitivity enhancement of the 2β decay investigation and of the search for dark matter particles with spin-dependent (SD) interaction. The results of CaF 2 (Eu) background measurements and simulation are presented. New and highly improved T 1/2 limits on the 2β decay of 46 Ca and the double electron capture of 40 Ca are obtained

Impact of seawater [Ca

NARCIS (Netherlands)

Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G.J.; de Nooijer, L.J.; Bijma, J.

2015-01-01

Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

Bulgaaria valitsus tahab USA raketikilpi / Mihkel Niglas

Index Scriptorium Estoniae

Niglas, Mihkel

2007-01-01

Bulgaarias küsiti USA presidendilt George W. Bushilt, miks Poolasse ja Tšehhi kavandatav raketikilp ei hakka katma Bulgaariat. USA paigutab septembris Bulgaaria sõjabaasi üle 3000 sõduri. George W. Bush toetab Bulgaaria nõudmist Liibüale vabastada Bulgaaria meditsiiniõed

CaV 3.1 and CaV 3.3 account for T-type Ca2+ current in GH3 cells

Directory of Open Access Journals (Sweden)

M.A. Mudado

2004-06-01

Full Text Available T-type Ca2+ channels are important for cell signaling by a variety of cells. We report here the electrophysiological and molecular characteristics of the whole-cell Ca2+ current in GH3 clonal pituitary cells. The current inactivation at 0 mV was described by a single exponential function with a time constant of 18.32 ± 1.87 ms (N = 16. The I-V relationship measured with Ca2+ as a charge carrier was shifted to the left when we applied a conditioning pre-pulse of up to -120 mV, indicating that a low voltage-activated current may be present in GH3 cells. Transient currents were first activated at -50 mV and peaked around -20 mV. The half-maximal voltage activation and the slope factors for the two conditions are -35.02 ± 2.4 and 6.7 ± 0.3 mV (pre-pulse of -120 mV, N = 15, and -27.0 ± 0.97 and 7.5 ± 0.7 mV (pre-pulse of -40 mV, N = 9. The 8-mV shift in the activation mid-point was statistically significant (P < 0.05. The tail currents decayed bi-exponentially suggesting two different T-type Ca2+ channel populations. RT-PCR revealed the presence of a1G (CaV3.1 and a1I (CaV3.3 T-type Ca2+ channel mRNA transcripts.

Nature of uranium contamination in the agricultural drainage water evaporation ponds of the San Joaquin Valley, California, USA

International Nuclear Information System (INIS)

Duff, M.C.; Amrhein, C.; Bradford, G.

1997-01-01

Evaporation ponds used for agricultural subsurface drainage water disposal in the Tulare Lake Bed (TLB) of the San Joaquin Valley, California, USA have elevated levels of U. Waterfowl which inhabit and forage the ponds and surrounding areas are threatened by exposure to U. The ponds, which receive irrigation drainage waters and seasonal rain, are subject to wetting and drying periods. The periods result in the accumulation of decaying algae and other organic material in surface sediments. Sediment and waters in the ponds were sampled to determine what factors control U solubility and sediment U concentrations. Data from a 1990 study conducted by Chilcott et al. in 1989 on the TLB ponds were used to help identify what factors may control U solubility. Pond sediment U concentrations decreased abruptly with depth and surface sediment U concentrations were related to dissolved Ca:HCO 3 ratios. Pond algal U bioaccumulation was favored in waters with high Ca:HCO 3 ratios, which had lower pH values and carbonate alkalinities than waters with low CA:HCO 3 ratios. Ponds with high salinities and high carbonate alkalinities contained the highest aqueous U concentrations relative to other TLB ponds. Sediment total organic carbon (TOC) was correlated with sediment U concentrations, suggesting that U is bound to organic matter. The source of TOC is most likely from algae deposition. (author)

USA suursaadik : toetame Eestit / Stanley Davis Phillips ; interv. Erkki Bahovski

Index Scriptorium Estoniae

Phillips, Stanley Davis

2007-01-01

USA suursaadik Eestis Stanley Davis Phillips vastab küsimustele, mis puudutavad USA positsiooni Tõnismäe pronkssõduri suhtes, Eesti saatkonna piiramist Moskvas, USA ja Venemaa suhteid ning koostööd, sõda terrorismiga, USA kava paigutada Tšehhi ja Poolasse raketitõrjebaasid, Eesti presidendi Toomas Hendrik Ilvese visiiti USAsse. Lisa: Stanley Davis Phillips. Ilmunud ka: Postimees : na russkom jazõke 16. mai lk. 5

Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling.

Science.gov (United States)

Swietach, Pawel; Youm, Jae-Boum; Saegusa, Noriko; Leem, Chae-Hun; Spitzer, Kenneth W; Vaughan-Jones, Richard D

2013-05-28

Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to complex spatial Ca(2+)/H(+) coupling. This was studied by fluorescence imaging of cardiac myocytes. An increase in [H(+)]i, produced by superfusion of acetate (salt of membrane-permeant weak acid), evoked a [Ca(2+)]i rise, independent of sarcolemmal Ca(2+) influx or release from mitochondria, sarcoplasmic reticulum, or acidic stores. Photolytic H(+) uncaging from 2-nitrobenzaldehyde also raised [Ca(2+)]i, and the yield was reduced following inhibition of glycolysis or mitochondrial respiration. H(+) uncaging into buffer mixtures in vitro demonstrated that Ca(2+) unloading from proteins, histidyl dipeptides (HDPs; e.g., carnosine), and ATP can underlie the H(+)-evoked [Ca(2+)]i rise. Raising [H(+)]i tonically at one end of a myocyte evoked a local [Ca(2+)]i rise in the acidic microdomain, which did not dissipate. The result is consistent with uphill Ca(2+) transport into the acidic zone via Ca(2+)/H(+) exchange on diffusible HDPs and ATP molecules, energized by the [H(+)]i gradient. Ca(2+) recruitment to a localized acid microdomain was greatly reduced during intracellular Mg(2+) overload or by ATP depletion, maneuvers that reduce the Ca(2+)-carrying capacity of HDPs. Cytoplasmic HDPs and ATP underlie spatial Ca(2+)/H(+) coupling in the cardiac myocyte by providing ion exchange and transport on common buffer sites. Given the abundance of cellular HDPs and ATP, spatial Ca(2+)/H(+) coupling is likely to be of general importance in cell signaling.

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Indian Academy of Sciences (India)

Barbara, CA, USA. H. David Politzer, California Institute of Technology, Pasadena, CA, USA. Frank Wilczek, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. Chemistry - ''for the discovery of ubiquitin-mediated protein degradation" to. Aaron Ciechanover, Technion - Israel Institute of Technology, Haifa, ...

Polyamines mediate abnormal Ca2+ transport and Ca2+-induced cardiac cell injury in the calcium paradox

International Nuclear Information System (INIS)

Trout, J.J.; Koenig, H.; Goldstone, A.D.; Lu, C.Y.; Fan, C.C.

1986-01-01

Ca 2+ -free perfusion renders heart cells Ca 2+ -sensitive so that readmission of Ca 2+ causes a sudden massive cellular injury attributed to abnormal entry of Ca 2+ into cells (Ca paradox). Hormonal stimulation of Ca 2+ fluxes was earlier shown to be mediated by polyamines (PA). 5 min perfusion of rat heart with Ca 2+ -free medium induce a prompt 40-50% decline in levels of the PA putrescine (PUT), spermidine and spermine and their rate-regulatory synthetic enzyme ornithine decarboxylase (ODC), and readmission of Ca 2+ -containing medium abruptly ( 2+ reperfusion-induced increases in ODC and PA and also prevented increased 45 Ca 2+ uptake and heart injury, manifested by loss of contractility, release of enzymes (CPK, LDH), myoglobin and protein, and E.M. lesions (contracture bands, mitochondrial changes). 1 mM PUT negated DFMO inhibition, repleted heart PA and restored Ca 2+ reperfusion-induced 45 Ca 2+ influx and cell injury. These data indicate that the Ca 2+ -directed depletion-repletion cycle of ODC and PA triggers excessive transsarcolemmal Ca 2+ transport leading to the calcium paradox

Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA.

Directory of Open Access Journals (Sweden)

Sen Li

Full Text Available Intracellular pH (pHi and Ca(2+ regulate essentially all aspects of cellular activities. Their inter-relationship has not been mechanistically explored. In this study, we used bases and acetic acid to manipulate the pHi. We found that transient pHi rise induced by both organic and inorganic bases, but not acidification induced by acid, produced elevation of cytosolic Ca(2+. The sources of the Ca(2+ increase are from the endoplasmic reticulum (ER Ca(2+ pools as well as from Ca(2+ influx. The store-mobilization component of the Ca(2+ increase induced by the pHi rise was not sensitive to antagonists for either IP(3-receptors or ryanodine receptors, but was due to inhibition of the sarco/endoplasmic reticulum Ca(2+-ATPase (SERCA, leading to depletion of the ER Ca(2+ store. We further showed that the physiological consequence of depletion of the ER Ca(2+ store by pHi rise is the activation of store-operated channels (SOCs of Orai1 and Stim1, leading to increased Ca(2+ influx. Taken together, our results indicate that intracellular alkalinization inhibits SERCA activity, similar to thapsigargin, thereby resulting in Ca(2+ leak from ER pools followed by Ca(2+ influx via SOCs.

Edward C. Little Water Recycling Plant, El Segundo, CA: CA0063401

Science.gov (United States)

Joint EPA and Los Angeles Regional Water Quality Control Board NPDES Permit and Waiver from Secondary Treatment for the West Basin Municipal Water District Edward C. Little Water Recycling Plant, El Segundo, CA: CA0063401

Large conductance Ca2+-activated K+ (BK channel: Activation by Ca2+ and voltage

Directory of Open Access Journals (Sweden)

RAMÓN LATORRE

2006-01-01

Full Text Available Large conductance Ca2+-activated K+ (BK channels belong to the S4 superfamily of K+ channels that include voltage-dependent K+ (Kv channels characterized by having six (S1-S6 transmembrane domains and a positively charged S4 domain. As Kv channels, BK channels contain a S4 domain, but they have an extra (S0 transmembrane domain that leads to an external NH2-terminus. The BK channel is activated by internal Ca2+, and using chimeric channels and mutagenesis, three distinct Ca2+-dependent regulatory mechanisms with different divalent cation selectivity have been identified in its large COOH-terminus. Two of these putative Ca2+-binding domains activate the BK channel when cytoplasmic Ca2+ reaches micromolar concentrations, and a low Ca2+ affinity mechanism may be involved in the physiological regulation by Mg2+. The presence in the BK channel of multiple Ca2+-binding sites explains the huge Ca2+ concentration range (0.1 μM-100 μM in which the divalent cation influences channel gating. BK channels are also voltage-dependent, and all the experimental evidence points toward the S4 domain as the domain in charge of sensing the voltage. Calcium can open BK channels when all the voltage sensors are in their resting configuration, and voltage is able to activate channels in the complete absence of Ca2+. Therefore, Ca2+ and voltage act independently to enhance channel opening, and this behavior can be explained using a two-tiered allosteric gating mechanism.

Viisavabadus USA-ga läheneb vaidlustes / Ahto Lobjakas

Index Scriptorium Estoniae

Lobjakas, Ahto, 1970-

2008-01-01

USA soovib Eesti kodanike viisanõudest vabastamiseks kõrgendatud turvameetmeid. Viisavabadust taotlev Tšehhi sõlmis USA-ga vastastikuse mõistmise memorandumi, EL-i nn. vanad liikmesriigid ja Euroopa Komisjon süüdistavad USA-ga kahepoolsete lepingute sõlmijaid Euroopa ühtsuse lõhestamises. Lisa: Eesti sõlmib lepingu ilmselt märtsi keskel

Influence of ER leak on resting cytoplasmic Ca2+ and receptor-mediated Ca2+ signalling in human macrophage.

Science.gov (United States)

Layhadi, Janice A; Fountain, Samuel J

2017-06-03

Mechanisms controlling endoplasmic reticulum (ER) Ca 2+ homeostasis are important regulators of resting cytoplasmic Ca 2+ concentration ([Ca 2+ ] cyto ) and receptor-mediated Ca 2+ signalling. Here we investigate channels responsible for ER Ca 2+ leak in THP-1 macrophage and human primary macrophage. In the absence of extracellular Ca 2+ we employ ionomycin action at the plasma membrane to stimulate ER Ca 2+ leak. Under these conditions ionomycin elevates [Ca 2+ ] cyto revealing a Ca 2+ leak response which is abolished by thapsigargin. IP 3 receptors (Xestospongin C, 2-APB), ryanodine receptors (dantrolene), and translocon (anisomycin) inhibition facilitated ER Ca 2+ leak in model macrophage, with translocon inhibition also reducing resting [Ca 2+ ] cyto . In primary macrophage, translocon inhibition blocks Ca 2+ leak but does not influence resting [Ca 2+ ] cyto . We identify a role for translocon-mediated ER Ca 2+ leak in receptor-mediated Ca 2+ signalling in both model and primary human macrophage, whereby the Ca 2+ response to ADP (P2Y receptor agonist) is augmented following anisomycin treatment. In conclusion, we demonstrate a role of ER Ca 2+ leak via the translocon in controlling resting cytoplasmic Ca 2+ in model macrophage and receptor-mediated Ca 2+ signalling in model macrophage and primary macrophage. Copyright © 2017 Elsevier Inc. All rights reserved.

Combined Evaluation of AFP, CA15-3, CA125, CA19-9, and CEA Tumor Markers in Patients with Hepatitis B and C.

Science.gov (United States)

Assmar, Mehdi; Yeganeh, Sara; Mansourghanaei, Fariborz; Amirmozafari, Nour

2016-12-01

This study aimed to determine the role of tumor markers AFP, CA15-3, CA125, CA19-9 and CEA in patients with hepatitis B and C. This descriptive cross-sectional study was performed from Oct 2012 to Oct 2014. Serum samples of 129 patients with hepatitis B and C referred to Guilan Liver and Digestive Disease Research Center in Rasht, Iran were collected and checked for the existence of the listed tumor markers by ELISA. No increase in serum levels of tumor marker CA19-9, CEA and CA15-3 were seen in patients with hepatitis ( P >0.05). In patients with hepatitis B, increase in CA125 were observed ( P =0.03). In hepatitis C patients, there was an increase in AFP levels ( P =0.03). The levels of AFP and CA125 markers were high in hepatitis C and hepatitis B, respectively. However, the increased levels were not seen is malignancy. Due to the small sample size, further study is necessary to find the reasons of the increase.

Läbikatsumine USA lennujaamades riivab siin tehtavast vähem / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2010-01-01

USA sisejulgeoleku ministeeriumi privaatsuse ja andmekaitse juht Mary Ellen Callahan kinnitab, et USA-sse reisivate inimeste krediitkaardiandmeid kasutatakse vaid elektroonilise reisi autoriseerimise süsteemi jaoks ning andmeid säilitab USA rahandusministeerium. Ta on arvamusel, et USA-s on kehaskannerite kasutamisel reisija privaatsuse kaitse parem kui Euroopas

The situation of nuclear energy in the USA

International Nuclear Information System (INIS)

Barthelt, K.

1984-01-01

Owing to the fact that peaceful utilization of nuclear energy receives much coverage in the mass media, at party congresses and lately even in respectable journals in a way characterized by much emotional commitment and little factual knowledge, there is a danger of transferring the situation in the USA too easily to the Federal Republic of Germany along with all those well-known arguments. In the article, the author points out the differences between the continent USA and the comparatively small country Federal Republic of Germany reading the conclusion that any sweeping comparison of both countries is misleading so, too, in energy supply. In detail, there is a brief overview on the historical development of nuclear power utilization in the USA, a discussion of the reasons for cancelling/shutting-down nuclear power plants in the USA, an analysis of the effects of modified demand predictions on power station construction and of funding problems as well as an investigation into the profitability of nuclear energy in the USA. (orig./UA) [de

Integration of GCAM-USA into GLIMPSE: Update and ...

Science.gov (United States)

The purpose of this presentation is to (i) discuss changes made to the GCAM-USA model to more fully support long-term, coordinated environmental-climate-energy planning within the U.S., and (ii) demonstrate the graphical user interface that has been constructed to construct modeling scenarios, execute GCAM-USA, and visualize and compare model outputs. GLIMPSE is intended to provide insights into linkages and synergies among the goals of air quality management, climate change mitigation, and long-range energy planning. We have expanded GLIMPSE to also incorporate the open-source Global Change Assessment Model-USA (GCAM-USA), which has state-level representation of the U.S. energy system. With GCAM-USA, GLIMPSE can consider more aspects of the economy, linkages to the water and climate systems, and interactions with other regions of the world. A user-friendly graphical interface allows the system to be applied by analysts to explore a range of policies, such emission taxes or caps, efficiency standards, and renewable portfolio standards. We expect GLIMPSE to be used within research and planning activities, both within the EPA and beyond.

Photosynthetic and growth response of sugar maple (Acer saccharum Marsh.) mature trees and seedlings to calcium, magnesium, and nitrogen additions in the Catskill Mountains, NY, USA

Science.gov (United States)

Momen, Bahram; Behling, Shawna J; Lawrence, Gregory B.; Sullivan, Joseph H

2015-01-01

Decline of sugar maple in North American forests has been attributed to changes in soil calcium (Ca) and nitrogen (N) by acidic precipitation. Although N is an essential and usually a limiting factor in forests, atmospheric N deposition may cause N-saturation leading to loss of soil Ca. Such changes can affect carbon gain and growth of sugar maple trees and seedlings. We applied a 22 factorial arrangement of N and dolomitic limestone containing Ca and Magnesium (Mg) to 12 forest plots in the Catskill Mountain region of NY, USA. To quantify the short-term effects, we measured photosynthetic-light responses of sugar maple mature trees and seedlings two or three times during two summers. We estimated maximum net photosynthesis (An-max) and its related light intensity (PAR at An-max), apparent quantum efficiency (Aqe), and light compensation point (LCP). To quantify the long-term effects, we measured basal area of living mature trees before and 4 and 8 years after treatment applications. Soil and foliar chemistry variables were also measured. Dolomitic limestone increased Ca, Mg, and pH in the soil Oe horizon. Mg was increased in the B horizon when comparing the plots receiving N with those receiving CaMg. In mature trees, foliar Ca and Mg concentrations were higher in the CaMg and N+CaMg plots than in the reference or N plots; foliar Ca concentration was higher in the N+CaMg plots compared with the CaMg plots, foliar Mg was higher in the CaMg plots than the N+CaMg plots; An-max was maximized due to N+CaMg treatment; Aqe decreased by N addition; and PAR at An-max increased by N or CaMg treatments alone, but the increase was maximized by their combination. No treatment effect was detected on basal areas of living mature trees four or eight years after treatment applications. In seedlings, An-max was increased by N+CaMg addition. The reference plots had an open herbaceous layer, but the plots receiving N had a dense monoculture of common woodfern in the

Photosynthetic and Growth Response of Sugar Maple (Acer saccharum Marsh.) Mature Trees and Seedlings to Calcium, Magnesium, and Nitrogen Additions in the Catskill Mountains, NY, USA.

Science.gov (United States)

Momen, Bahram; Behling, Shawna J; Lawrence, Greg B; Sullivan, Joseph H

2015-01-01

Decline of sugar maple in North American forests has been attributed to changes in soil calcium (Ca) and nitrogen (N) by acidic precipitation. Although N is an essential and usually a limiting factor in forests, atmospheric N deposition may cause N-saturation leading to loss of soil Ca. Such changes can affect carbon gain and growth of sugar maple trees and seedlings. We applied a 22 factorial arrangement of N and dolomitic limestone containing Ca and Magnesium (Mg) to 12 forest plots in the Catskill Mountain region of NY, USA. To quantify the short-term effects, we measured photosynthetic-light responses of sugar maple mature trees and seedlings two or three times during two summers. We estimated maximum net photosynthesis (An-max) and its related light intensity (PAR at An-max), apparent quantum efficiency (Aqe), and light compensation point (LCP). To quantify the long-term effects, we measured basal area of living mature trees before and 4 and 8 years after treatment applications. Soil and foliar chemistry variables were also measured. Dolomitic limestone increased Ca, Mg, and pH in the soil Oe horizon. Mg was increased in the B horizon when comparing the plots receiving N with those receiving CaMg. In mature trees, foliar Ca and Mg concentrations were higher in the CaMg and N+CaMg plots than in the reference or N plots; foliar Ca concentration was higher in the N+CaMg plots compared with the CaMg plots, foliar Mg was higher in the CaMg plots than the N+CaMg plots; An-max was maximized due to N+CaMg treatment; Aqe decreased by N addition; and PAR at An-max increased by N or CaMg treatments alone, but the increase was maximized by their combination. No treatment effect was detected on basal areas of living mature trees four or eight years after treatment applications. In seedlings, An-max was increased by N+CaMg addition. The reference plots had an open herbaceous layer, but the plots receiving N had a dense monoculture of common woodfern in the forest floor

Ruslands betændte forhold til USA

DEFF Research Database (Denmark)

Skak, Mette

2015-01-01

Rusland udgør en anden stormagtsudfordring for USA. Rusland er en stormagt i forfald, som imidlertid har genopfundet sin gamle sovjetiske 'Manifest Destiny'.......Rusland udgør en anden stormagtsudfordring for USA. Rusland er en stormagt i forfald, som imidlertid har genopfundet sin gamle sovjetiske 'Manifest Destiny'....

Valitsus vaeb USA viisavabadusenõudeid / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2008-01-01

USA viisavabaduse aluseks oleva vastastikuse mõistmise memorandumi projekt on täna valitsuse istungi päevakorras. Tšehhi ja USA on juba sõlminud kahepoolse memorandumi, mõnedel hinnangutel on Tšehhi järele andnud kogu ameeriklaste nõudmiste paketile. Lisa: Andmekaitsjad pole viimase seisuga kursis

Echinococcus granulosus in gray wolves and ungulates in Idaho and Montana, USA.

Science.gov (United States)

Foreyt, William J; Drew, Mark L; Atkinson, Mark; McCauley, Deborah

2009-10-01

We evaluated the small intestines of 123 gray wolves (Canis lupus) that were collected from Idaho, USA (n=63), and Montana, USA (n=60), between 2006 and 2008 for the tapeworm Echinococcus granulosus. The tapeworm was detected in 39 of 63 wolves (62%) in Idaho, USA, and 38 of 60 wolves (63%) in Montana, USA. The detection of thousands of tapeworms per wolf was a common finding. In Idaho, USA, hydatid cysts, the intermediate form of E. granulosus, were detected in elk (Cervus elaphus), mule deer (Odocoileus hemionus), and a mountain goat (Oreamnos americanus). In Montana, USA, hydatid cysts were detected in elk. To our knowledge, this is the first report of adult E. granulosus in Idaho, USA, or Montana, USA. It is unknown whether the parasite was introduced into Idaho, USA, and southwestern Montana, USA, with the importation of wolves from Alberta, Canada, or British Columbia, Canada, into Yellowstone National Park, Wyoming, USA, and central Idaho, USA, in 1995 and 1996, or whether the parasite has always been present in other carnivore hosts, and wolves became a new definitive host. Based on our results, the parasite is now well established in wolves in these states and is documented in elk, mule deer, and a mountain goat as intermediate hosts.

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

Directory of Open Access Journals (Sweden)

Peter Rellos

2010-07-01

Full Text Available Long-term potentiation (LTP, a long-lasting enhancement in communication between neurons, is considered to be the major cellular mechanism underlying learning and memory. LTP triggers high-frequency calcium pulses that result in the activation of Calcium/Calmodulin (CaM-dependent kinase II (CaMKII. CaMKII acts as a molecular switch because it remains active for a long time after the return to basal calcium levels, which is a unique property required for CaMKII function. Here we describe the crystal structure of the human CaMKIIdelta/Ca2+/CaM complex, structures of all four human CaMKII catalytic domains in their autoinhibited states, as well as structures of human CaMKII oligomerization domains in their tetradecameric and physiological dodecameric states. All four autoinhibited human CaMKIIs were monomeric in the determined crystal structures but associated weakly in solution. In the CaMKIIdelta/Ca2+/CaM complex, the inhibitory region adopted an extended conformation and interacted with an adjacent catalytic domain positioning T287 into the active site of the interacting protomer. Comparisons with autoinhibited CaMKII structures showed that binding of calmodulin leads to the rearrangement of residues in the active site to a conformation suitable for ATP binding and to the closure of the binding groove for the autoinhibitory helix by helix alphaD. The structural data, together with biophysical interaction studies, reveals the mechanism of CaMKII activation by calmodulin and explains many of the unique regulatory properties of these two essential signaling molecules.This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3-D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the Web plugin are available in Text S1.

Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

Science.gov (United States)

Wang, Wei; Chen, Xiao-Long; Zhao, Shen-Yu; Xu, Yu-Hui; Zhang, Wei-Han; Liu, Kai; Chen, Xin-Zu; Yang, Kun; Zhang, Bo; Chen, Zhi-Xin; Chen, Jia-Ping; Zhou, Zong-Guang; Hu, Jian-Kun

2016-01-01

The prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma (GC) has been widely reported and is still under debate. Here, we evaluated the prognostic significance of preoperative serum CA125, CA19-9 and CEA in patients with GC. 1692 patients with GC who underwent gastrectomy were divided into the training (from January 2005 to December 2011, n = 1024) and the validation (from January 2012 to December 2013, n = 668) cohorts. Positive groups of CA125 (> 13.72 U/ml), CA19-9 (> 23.36 U/ml) and CEA (> 4.28 ng/ml) were significantly associated with more advanced clinicopathological traits and worse outcomes than that of negative groups (all P tumor size (P tumor markers (NPTM) were more accurate in prognostic prediction than TNM stage alone. Our findings suggested that elevated preoperative serum CA125, CA19-9 and CEA were associated with more advanced clinicopathological traits and less favorable outcomes. In addition, CA125 as an independent prognostic factor should be further investigated. Nomogram based on NPTM could accurately predict the prognosis of GC patients. PMID:27097114

Impact parameter determination for 40Ca + 40Ca reactions using a neural network

International Nuclear Information System (INIS)

Haddad, F.; Hagel, K.; Li, J.; Mdeiwayeh, N.; Natowitz, J.B.; Wada, R.; Xiao, B.; David, C.; Freslier, M.; Aichelin, J.

1995-01-01

A neural network is used for the impact parameter determination in 40 Ca + 40 Ca reactions at energies between 35 and 70 AMeV. A special attention is devoted to the effect of experimental constraints such as the detection efficiency. An overall improvement of the impact parameter determination of 25% is obtained with the neural network. The neural network technique is then used in the analysis of the Ca+Ca data at 35 AMeV and allows separation of three different class of events among the selected 'complete' events. (authors). 8 refs., 5 figs

PGC-1α accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes

International Nuclear Information System (INIS)

Chen, Min; Wang, Yanru; Qu, Aijuan

2010-01-01

Energy metabolism and Ca 2+ handling serve critical roles in cardiac physiology and pathophysiology. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a multi-functional coactivator that is involved in the regulation of cardiac mitochondrial functional capacity and cellular energy metabolism. However, the regulation of PGC-1α in cardiac Ca 2+ signaling has not been fully elucidated. To address this issue, we combined confocal line-scan imaging with off-line imaging processing to characterize calcium signaling in cultured adult rat ventricular myocytes expressing PGC-1α via adenoviral transduction. Our data shows that overexpressing PGC-1α improved myocyte contractility without increasing the amplitude of Ca 2+ transients, suggesting that myofilament sensitivity to Ca 2+ increased. Interestingly, the decay kinetics of global Ca 2+ transients and Ca 2+ waves accelerated in PGC-1α-expressing cells, but the decay rate of caffeine-elicited Ca 2+ transients showed no significant change. This suggests that sarcoplasmic reticulum (SR) Ca 2+ -ATPase (SERCA2a), but not Na + /Ca 2+ exchange (NCX) contribute to PGC-1α-induced cytosolic Ca 2+ clearance. Furthermore, PGC-1α induced the expression of SERCA2a in cultured cardiac myocytes. Importantly, overexpressing PGC-1α did not disturb cardiac Ca 2+ homeostasis, because SR Ca 2+ load and the propensity for Ca 2+ waves remained unchanged. These data suggest that PGC-1α can ameliorate cardiac Ca 2+ cycling and improve cardiac work output in response to physiological stress. Unraveling the PGC-1α-calcium handing pathway sheds new light on the role of PGC-1α in the therapy of cardiac diseases.

Optically stimulated luminescence age controls on late Pleistocene and Holocene coastal lithosomes, North Carolina, USA

Science.gov (United States)

Mallinson, D.; Burdette, K.; Mahan, S.; Brook, G.

2008-01-01

Luminescence ages from a variety of coastal features on the North Carolina Coastal Plain provide age control for shoreline formation and relative sea-level position during the late Pleistocene. A series of paleoshoreline ridges, dating to Marine Isotope Stage (MIS) 5a and MIS 3 have been defined. The Kitty Hawk beach ridges, on the modern Outer Banks, yield ages of 3 to 2??ka. Oxygen-isotope data are used to place these deposits in the context of global climate and sea-level change. The occurrence of MIS 5a and MIS 3 shorelines suggests that glacio-isostatic adjustment (GIA) of the study area is large (ca. 22 to 26??m), as suggested and modeled by other workers, and/or MIS 3 sea level was briefly higher than suggested by some coral reef studies. Correcting the shoreline elevations for GIA brings their elevation in line with other sea-level indicators. The age of the Kitty Hawk beach ridges places the Holocene shoreline well west of its present location at ca. 3 to 2??ka. The age of shoreline progradation is consistent with the ages of other beach ridge complexes in the southeast USA, suggesting some regionally contemporaneous forcing mechanism. ?? 2007 University of Washington.

Comparison of phosgene, chlorine, and hydrogen chloride as reagents for converting molten CaO.CaCl2 to CaCl2

International Nuclear Information System (INIS)

Fife, K.W.

1985-01-01

One method at Los Alamos for preparing impure plutonium metal from the impure oxide is by batch reduction with calcium metal at 850 0 C in a CaCl 2 solvent. The solvent salt from this reduction is currently discarded as low-level radioactivity waste only because it is saturated with the CaO byproduct. We have demonstrated a pyrochemical technique for converting the CaO to CaCl 2 thereby incorporating solvent recycling into the batch reduction process. We will discuss the effectiveness of HCl, Cl 2 , and COCl 2 as chlorinating agents and recycling actual spent process solvent salts. 6 refs., 8 figs

Collective versus single-particle motion in quantum many-body systems from the perspective of an integrable model

Energy Technology Data Exchange (ETDEWEB)

Haemmerling, Jens; Gutkin, Boris; Guhr, Thomas, E-mail: jens.haemmerling@uni-due.d [Universitaet Duisburg-Essen, Lotharstrasse 1, 47048 Duisburg (Germany)

2010-07-02

We study the emergence of collective dynamics in the integrable Hamiltonian system of two finite ensembles of coupled harmonic oscillators. After identification of a collective degree of freedom, the Hamiltonian is mapped onto a model of Caldeira-Leggett type, where the collective coordinate is coupled to an internal bath of phonons. In contrast to the usual Caldeira-Leggett model, the bath in the present case is part of the system. We derive an equation of motion for the collective coordinate which takes the form of a damped harmonic oscillator. We show that the distribution of quantum transition strengths induced by the collective mode is determined by its classical dynamics.

Collective versus single-particle motion in quantum many-body systems from the perspective of an integrable model

International Nuclear Information System (INIS)

Haemmerling, Jens; Gutkin, Boris; Guhr, Thomas

2010-01-01

We study the emergence of collective dynamics in the integrable Hamiltonian system of two finite ensembles of coupled harmonic oscillators. After identification of a collective degree of freedom, the Hamiltonian is mapped onto a model of Caldeira-Leggett type, where the collective coordinate is coupled to an internal bath of phonons. In contrast to the usual Caldeira-Leggett model, the bath in the present case is part of the system. We derive an equation of motion for the collective coordinate which takes the form of a damped harmonic oscillator. We show that the distribution of quantum transition strengths induced by the collective mode is determined by its classical dynamics.

77 FR 47671 - TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA-W-81,520G, T-Mobile USA, Inc...

Science.gov (United States)

2012-08-09

... DEPARTMENT OF LABOR Employment and Training Administration TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA- W-81,520G, T-Mobile USA, Inc., Headquarters Office, Bellevue, WA; Amended... of T-Mobile USA, Inc., Call Center, Allentown, Pennsylvania (TA-W-81,520), Fort Lauderdale, Florida...

The center-to-limb behavior of CaI lambda 6573 and [Ca II] lambda 7324

International Nuclear Information System (INIS)

Ayres, T.R.; Testerman, L.

1978-01-01

Center-to-limb measurements of the Ca I lambda 6573 intercombination line and the Ca II lambda 7324 forbidden line are compared with synthetic profiles based on a simple representation of the non-LTE Ca-Ca + ionization equilibrium. The effects of photoionization from low lying excited states of neutral calcium are found to reduce the sensitivity of the lambda 6573 center-to-limb behavior as a thermal structure diagnostic. The synthetic center-to-limb behavior is also sensitive to uncertainties in the nonthermal broadening. Nevertheless, the measured center-to-limb behavior of lambda 6573 favors a 'cool' photospheric model similar to the Vernazza, Avrett, and Loeser model M over hotter models based on the Ca II K wings. The non-LTE calcium abundance obtained from the disk center equivalent widths of lambda 6573 and lambda 7324 using the best fit model is Asub(Ca)approximately=2.1+-0.2x10 -6 (by number relative to hydrogen). Applications of these lines as diagnostics of the Ca-Ca + ionization equilibrium in other stars are briefly discussed. (Auth.)

USA välisminister kaitses CIA salaaktsioone vangidega / Aadu Hiietamm

Index Scriptorium Estoniae

Hiietamm, Aadu, 1954-

2005-01-01

USA välisminister Condoleezza Rice kaitses Berliinis USA Luure Keskagentuuri (CIA) salaaktsioone. Välisminister teatas, et USA ei piina vange ning kinnipeetavate välisriikidesse toimetamise eesmärk on vältida terrorirünnakuid ja päästa inimelusid

Tšehhi võimud tahavad endale USA raketikilpi / Krister Paris

Index Scriptorium Estoniae

Paris, Krister, 1977-

2006-01-01

USA rajab 2011. aastaks raketirünnakute tõrje süsteemi. Raketikilbi Euroopa-keskuse asukohale kandideerivad Tšehhi ja Poola, samas on suur osa tshehhe USA baasi rajamise vastu. Skeem: USA tähesõdade programm. Lisa: Peaminister vaid nime poolest

Nanosilica supported CaO: A regenerable and mechanically hard CO2 sorbent at Ca-looping conditions

International Nuclear Information System (INIS)

Sanchez-Jimenez, P.E.; Perez-Maqueda, L.A.; Valverde, J.M.

2014-01-01

Highlights: • A synthetic CO 2 sorbent is prepared by impregnation of calcium nitrate on a nanosilica matrix. • Sintering of the nascent CaO in the calcination stage of carbonation/calcination cycles is hindered. • CaO conversion reaches a stable value well above the residual conversion of natural limestone. • Particle fragmentation as caused by ultrasonic irradiation in a liquid dispersion is hindered. - Abstract: This work presents a CO 2 sorbent that may be synthesized from low-cost and widely available materials following a simple method basically consisting of impregnation of a nanostructured silica support with a saturated solution of calcium nitrate. In a first impregnation stage, the use of a stoichiometric CaO/SiO 2 ratio serves to produce a calcium silicate matrix after calcination. This calcium silicate matrix acts as a thermally stable and mechanically hard support for CaO deposited on it by further impregnation. The CaO-impregnated sorbent exhibits a stable CaO conversion at Ca-looping conditions whose value depends on the CaO wt% deposited on the calcium silicate matrix, which can be increased by successive reimpregnations. A 10 wt% CaO impregnated sorbent reaches a stable conversion above 0.6 whereas the stable conversion of a 30 wt% CaO impregnated sorbent is around 0.3, which is much larger than the residual conversion of CaO derived from natural limestone (between 0.07 and 0.08). Moreover, particle size distribution measurements of samples predispersed in a liquid and subjected to high energy ultrasonic waves indicate that the CaO-impregnated sorbent has a relatively high mechanical strength as compared to limestone derived CaO

USA Hire Testing Platform

Data.gov (United States)

Office of Personnel Management — The USA Hire Testing Platform delivers tests used in hiring for positions in the Federal Government. To safeguard the integrity of the hiring processes and ensure...

Thermoluminescence of CaCO3:Dy and CaCO3:Mn

International Nuclear Information System (INIS)

Bapat, V.N.; Nambi, K.S.V.

1976-01-01

CaCO 3 samples doped with Dy and Mn were prepared in the laboratory by co-precipitation techniques. Thermoluminescence and emission spectra of these phosphors were studied and were compared with those of the naturally occuring calcite and undoped CaCO 3 samples. Dy-doping seems to give a more efficient phosphor and indicates a possibility of getting a better phosphor by a judicious choice of a rare earth doping of CaCO 3 . Interesting result have been obtained on the TL glow curve variations of these phosphors with different temperature treatments prior to irradiation. (author)

Chemical purification of CaCO{sub 3} and CaWO{sub 4} powders used for CaWO{sub 4} crystal production for the CRESST experiment

Energy Technology Data Exchange (ETDEWEB)

Trinh Thi, H.H.; Defay, X.; Erb, A.; Hampf, R.; Lanfranchi, J.C.; Langenkaemper, A.; Morgalyuk, V.; Muenster, A.; Mondragon, E.; Oppenheimer, C.; Potzel, W.; Schoenert, S.; Steiger, H.; Ulrich, A.; Wawoczny, S.; Willers, M.; Zoeller, A. [Physik-Department and Excellence Cluster Universe, Technische Universitaet Muenchen, Garching (Germany)

2016-07-01

CRESST (Cryogenic Rare Event Search with Superconducting Thermometers) uses CaWO{sub 4} single crystals as targets for the direct search for dark matter particles. Since several years these CaWO{sub 4} crystals are grown at the Technische Universitaet Muenchen. Thereby, commercially available CaCO{sub 3} and WO{sub 3} powders are used for the synthesis of CaWO{sub 4} powder. For the experiment low intrinsic contaminations of the crystals play a crucial role. In order to improve the radiopurity of the crystals it is necessary to reduce potential sources for radioactive backgrounds such as U and Th. In this poster we will present our studies of the chemical purification of the CaCO{sub 3} and CaWO{sub 4} powders.

Ischemic damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3

DEFF Research Database (Denmark)

Benveniste, H; Jørgensen, M B; Sandberg, M

1989-01-01

The removal of glutamatergic afferents to CA1 by destruction of the CA3 region is known to protect CA1 pyramidal cells against 10 min of transient global ischemia. To investigate further the pathogenetic significance of glutamate, we measured the release of glutamate in intact and CA3-lesioned CA...

Up-regulation of Ca2+/CaMKII/CREB signaling in salicylate-induced tinnitus in rats.

Science.gov (United States)

Zhao, Jiuhan; Wang, Biao; Wang, Xiaohong; Shang, Xiuli

2018-02-09

The purpose of the study was to investigate the changes of Ca 2+ /calmodulin-dependent protein kinases II (CaMKII)/cAMP response element-binding protein (CREB) signaling pathway in a rat tinnitus model. Eighteen Wistar rats were randomly divided into three groups: normal control (NC), normal saline (NS), and tinnitus model (TM) groups. Tinnitus model was induced by intraperitoneal injection of salicylate. The concentration of intracellular calcium level in auditory cortex cells was determined using Fura-2 acetoxymethyl ester (Fura-2 AM) method with fluorospectrophotometer. Expressions of calmodulin (CaM), N-methyl-D-aspartate receptor 2B subunit (NR2B), calcium-calmodulin kinase II (CaMKII), and cAMP response element-binding protein (CREB) were detected with Western blot. Tinnitus model was successfully established by the intraperitoneal administration of salicylate in rats. Compared with rats in NC and NS groups, salicylate administration significantly elevated CaM, NR2B, phospho-CaMKII and phospho-CREB expression in auditory cortex from tinnitus model group (p salicylate administration causes tinnitus symptoms and elevates Ca 2+ /CaMKII/CREB signaling pathway in auditory cortex cells. Our study likely provides a new understanding of the development of tinnitus.

Clinton: USA kaotab infosõjas Hiina, Venemaa ja Al Jazeeraga / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2011-01-01

USA välisministri Hillary Clintoni hinnangul on USA propaganda nõrgenenud ning USA mõjuvõim väheneb pidevalt. H. Clintoni vastusest Senati väliskomisjonis senaator Richard Lugari küsimusele USA pingutustest diplomaatilise kommunikatsiooni vallas

Ca isotopic fractionation patterns in forest ecosystems

Science.gov (United States)

Kurtz, A. C.; Takagi, K.

2012-12-01

Calcium stable isotope ratios are an emerging tracer of the biogeochemical cycle of Ca that are just beginning to see significant application to forest ecosystems. The primary source of isotopic fractionation in these systems is discrimination against light Ca during uptake by plant roots. Cycling of vegetation-fractionated Ca establishes isotopically distinct Ca pools within a forest ecosystem. In some systems, the shallow soil exchangeable Ca pool is isotopically heavy relative to Ca inputs. This has been explained by preferential removal of light Ca from the soil. In other systems, the soil exchange pool is isotopically light relative to inputs, which is explained by recycling of plant-fractionated light Ca back into soil. Thus vegetation uptake of light Ca has been called on to account for both isotopically heavy and light Ca in the shallow soil exchange pools. We interpret patterns in ecosystem δ44Ca with the aid of a simple box model of the forest Ca cycle. We suggest that the δ44Ca of exchangeable Ca in the shallow soil pool primarily reflects the relative magnitude of three key fluxes in a forest Ca cycle, 1) the flux of external Ca into the system via weathering or atmospheric deposition, 2) the uptake flux of Ca from soils into the vegetation pool, and 3) the return flux of Ca to shallow soils via remineralization of leaf litter. Two observations that emerge from our model may aid in the application of Ca isotopes to provide insight into the forest Ca cycle. First, regardless of the magnitude of both vegetation Ca uptake and isotopic fractionation, the δ44Ca of the soil exchange pool will equal the input δ44Ca unless the plant uptake and remineralization fluxes are out of balance. A second observation is that the degree to which the shallow soil exchange pool δ44Ca can differ from the input ratio is controlled by the relative rates of biological uptake and external Ca input. Significant differences between soil exchange and input δ44Ca are seen only

USA järelevalve e-side üle maailmas tugevneb / Tõnis Arnover

Index Scriptorium Estoniae

Arnover, Tõnis, 1952-

2007-01-01

USA Kongress võttis vastu seaduse, mis annab eriteenistustele suurema tegutsemisvabaduse rahvusvahelise e-side jälgimisel ning nõuab USA-d külastavate viisavabade riikide ärimeestelt eelinfot oma tegevuse kohta. Lisa: USA-s heakskiidetud terrorismivastased abinõud

Growth and nutrition of baldcypress families planted under varying salinity regimes in Louisiana, USA

Science.gov (United States)

Krauss, K.W.; Chambers, J.L.; Allen, J.A.; Soileau, D.M.; DeBosier, A.S.

2000-01-01

Saltwater intrusion from the Gulf of Mexico is one important factor in the destruction of baldcypress (Taxodium distichum (L.) Rich.) swamps along the Louisiana Gulf Coast, USA. Recent restoration efforts have focused on identification of baldcypress genotypes with greater tolerance to saline conditions than previously reported. To date, salt tolerance investigations have not been conducted under saline field conditions. In 1996, therefore, three plantations were established with 10 half-sib genotype collections of baldcypress in mesohaline wetlands. Tree survival and growth were measured at the end of two growing seasons, and foliar ion concentrations of Na, Cl, K, and Ca and available soil nutrients were measured during the 1996 growing season. In general, soil nutrient concentrations exceeded averages found in other baldcypress stands in the southeastern United States. Seedlings differed among sites in all parameters measured, with height, diameter, foliar biomass, and survival decreasing as site salinity increased. Average seedling height at the end of two years, for example, was 196.4 cm on the lowest salinity site and 121.6 cm on the highest. Several half-sib families maintained greater height growth increments (ranging from 25.5 to 54.5 cm on the highest salinity site), as well as lower foliar ion concentrations of K, Cl, and Ca. Results indicate that genotypic screening of baldcypress may improve growth and vigor of seedlings planted within wetlands impacted by saltwater intrusion.

Spin decomposition of the responses of 44Ca and 48Ca to 300 MeV protons

International Nuclear Information System (INIS)

Baker, F.T.; Bimbot, L.; Fergerson, R.W.; Glashausser, C.; Green, A.; Haeusser, O.; Hicks, K.; Jones, K.; Miller, C.A.; Vetterli, M.; Abegg, R.; Beatty, D.; Bonin, B.; Castel, B.; Chen, X.Y.; Cupps, V.; Djalali, C.; Henderson, R.; Jackson, K.P.; Jeppesen, R.; Nakayama, K.; Nanda, S.K.; Sawafta, R.; Yen, S.; Institut de Physique Nucleaire, F-91406 Orsay, France; Rutgers University, Piscataway, New Jersey 08854; Simon Fraser University, Burnaby, Canada V5A1S6; TRIUMF, 4004 Westbrook Mall, Vancouver, Canada V6T2A3; Los Alamos National Laboratory, Los Alamos, New Mexico 87544; Centre d'Etudes Nucleaires de Saclay, 91191 Gif sur Yvette, CEDEX, France; Queen's University, Kingston, Canada K7L3N6; University of Colorado, Boulder, Colorado 80309; University of South Carolina, Columbia, South Carolina 29208; Continuous Electron Beam Accelerator Facility, 12000 Jefferson Ave., Newport News, Virginia 23606; University of Alberta, Edmonton, Canada T6G2J1)

1991-01-01

Angular distributions of the double-differential cross section d 2 σ/dΩ dE(σ) and the spin-flip probability S nn have been measured for inclusive proton inelastic scattering from 44 Ca at 290 MeV and from 48 Ca at 318 MeV. Excitation energies up to about 50 MeV for 44 Ca and 40 MeV for 48 Ca have been investigated over the laboratory angular ranges of 3 degree to 12 degree for 44 Ca and 3 degree to 9 degree for 48 Ca. Multipole decompositions of angular distributions of both the spin-flip cross section σS nn and the estimated cross section for ΔS=0 transitions have been performed. Distributions of strengths were deduced for ΔL=1, ΔS=0 (the giant dipole), ΔL=2, ΔS=0 (the giant quadrupole), ΔL=0, ΔS=1 (the magnetic dipole), ΔL=1, ΔS=1 (the spin dipole), and ΔL=2, ΔS=1 (the spin quadrupole). The ΔS=0 summed strengths for 44 Ca are lower than for 40 Ca and 48 Ca. The spin-dipole summed strengths are found to be approximately independent of A. For 48 Ca, essentially all M1 strength observed was in the 10.23 MeV 1 + state; for 44 Ca, M1 strength was observed to be fragmented over a range of 7 to 18 Mev

Quantifying uncertainty in coral Sr/Ca-based SST estimates from Orbicella faveolata: A basis for multi-colony SST reconstructions

Science.gov (United States)

Richey, J. N.; Flannery, J. A.; Toth, L. T.; Kuffner, I. B.; Poore, R. Z.

2017-12-01

The Sr/Ca in massive corals can be used as a proxy for sea surface temperature (SST) in shallow tropical to sub-tropical regions; however, the relationship between Sr/Ca and SST varies throughout the ocean, between different species of coral, and often between different colonies of the same species. We aimed to quantify the uncertainty associated with the Sr/Ca-SST proxy due to sample handling (e.g., micro-drilling or analytical error), vital effects (e.g., among-colony differences in coral growth), and local-scale variability in microhabitat. We examine the intra- and inter-colony reproducibility of Sr/Ca records extracted from five modern Orbicella faveolata colonies growing in the Dry Tortugas, Florida, USA. The average intra-colony absolute difference (AD) in Sr/Ca of the five colonies during an overlapping interval (1997-2008) was 0.055 ± 0.044 mmol mol-1 (0.96 ºC) and the average inter-colony Sr/Ca AD was 0.039 ± 0.01 mmol mol-1 (0.51 ºC). All available Sr/Ca-SST data pairs from 1997-2008 were combined and regressed against the HadISST1 gridded SST data set (24 ºN and 82 ºW) to produce a calibration equation that could be applied to O. faveolata specimens from throughout the Gulf of Mexico/Caribbean/Atlantic region after accounting for the potential uncertainties in Sr/Ca-derived SSTs. We quantified a combined error term for O. faveolata using the root-sum-square (RMS) of the analytical, intra-, and inter-colony uncertainties and suggest that an overall uncertainty of 0.046 mmol mol-1 (0.81 ºC, 1σ), should be used to interpret Sr/Ca records from O. faveolata specimens of unknown age or origin to reconstruct SST. We also explored how uncertainty is affected by the number of corals used in a reconstruction by iteratively calculating the RMS error for composite coral time-series using two, three, four, and five overlapping coral colonies. Our results indicate that maximum RMS error at the 95% confidence interval on mean annual SST estimates is 1.4 º

USA erisaadik : USA investorid Eestis rahul / J. Frank Mermoud ; interv. Sirje Rank

Index Scriptorium Estoniae

Mermoud, J. Frank

2004-01-01

Ameerika Ühendriikide välisministri nõunik ja erisaadik majandusküsimustes kiidab Eesti edu, räägib USA investorite rahuolust Eesti majanduskeskkonnaga ja väljendab muret Euroopa Liidu kavade pärast maksude ühtlustamiseks

USA politoloogid : Obama võit oleks ka Eesti oma / Laura Vetik

Index Scriptorium Estoniae

Vetik, Laura

2008-01-01

USA politoloogide sõnul oleks pingestunud Venemaa ja USA suhete taustal Eestile kasulikum, kui 56. USA presidendivalimised võidaks demokraat Barack Obama. Erinevate politoloogide hinnanguid. Vt. samas: Obama ja McCain loovad kabinette

Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis.

Science.gov (United States)

Zhang, Yimin; Yang, Jun; Li, Hongjuan; Wu, Yihua; Zhang, Honghe; Chen, Wenhu

2015-01-01

Pancreatic cancer has the worst prognosis and early detection is crucial for improving patient prognosis. Therefore, we performed a meta-analysis to evaluate and compare the sensitivity and specificity of single test of CA19-9, CA242, and CEA, as well as combination test in pancreatic cancer detection. We searched PubMed, Embase, Medline, and Wanfang databases for studies that evaluated the diagnostic validity of CA19-9, CA242, and CEA between January 1990 and September 2014. Data were analyzed by Meta-Disc and STATA software. A total of 21 studies including 3497 participants, which fulfilled the inclusion criteria were considered for analysis. The pooled sensitivities for CA19-9, CA242, and CEA were 75.4 (95% CI: 73.4-77.4), 67.8 (95% CI: 65.5-70), and 39.5 (95% CI: 37.3-41.7), respectively. The pooled specificities of CA19-9, CA242, and CEA were 77.6 (95% CI: 75.4-79.7), 83 (95% CI: 81-85), and 81.3 (95% CI: 79.3-83.2), respectively. Parallel combination of CA19-9+CA242 has a higher sensitivity (89, 95% CI: 80-95) without impairing the specificity (75, 95% CI: 67-82). Our meta-analysis showed that CA242 and CA19-9 have better performance in the diagnosis of pancreatic cancer than CEA. Furthermore, parallel combination test of CA19-9+CA242 could be of better diagnostic value than individual CA242 or CA19-9 test.

USA ärritab Poolat ideega ehitada raketikilp hoopis Leetu / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2008-01-01

Kuigi USA ja Poola vahel jätkuvad läbirääkimised raketikilbi üle, on rahvusvahelisse meediasse imbunud oletus, et USA võib raketikilbi paigutada hoopis Leetu. Poola asevälisministri Witold Waszczykowski hinnangul kasutab USA Leedut survestusvahendina. Nii Leedu välisministeerium kui ka USA-poolne kõneluste juht John Rood kinnitavad, et raketikilbiküsimust on riigid omavahel arutanud

Ab-initio calculations of the Ruddlesden-Popper phases CaMnO3, CaO(CaMnO3) and CaO(CaMnO3)2

International Nuclear Information System (INIS)

Cardoso, C; Borges, R P; Gasche, T; Godinho, M

2008-01-01

The present work reports ab-initio density functional theory calculations for the Ruddlesden-Popper phase CaO(CaMnO 3 ) n compounds. In order to study the evolution of the properties with the number of perovskite layers, a detailed analysis of the densities of states calculated for each compound and for several magnetic configurations was performed. The effect of distortions of the crystal structure on the magnetic ground state is also analysed and the exchange constants and transition temperatures are calculated for the three compounds using a mean field model. The calculated magnetic ground state structures and magnetic moments are in good agreement with experimental results and previous calculations

Ameerikat sõtta õhutanud Iraagi prominent kaotas USA soosingu / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2004-01-01

Iraaklase Ahmed Chalabi tegevusest ja lubadustest USA Iraagi-vastase sõja alustamiseks. USA toetuse kahanemisest Chalabile ja süüdistustest, et ta andis salajast infot Iraanile USA vägede tegevuse kohta Iraagis

Quantifying Ca2+ release and inactivation of Ca2+ release in fast- and slow-twitch muscles.

Science.gov (United States)

Barclay, C J

2012-12-01

The aims of this study were to quantify the Ca(2+) release underlying twitch contractions of mammalian fast- and slow-twitch muscle and to comprehensively describe the transient inactivation of Ca(2+) release following a stimulus. Experiments were performed using bundles of fibres from mouse extensor digitorum longus (EDL) and soleus muscles. Ca(2+) release was quantified from the amount of ATP used to remove Ca(2+) from the myoplasm following stimulation. ATP turnover by crossbridges was blocked pharmacologically (N-benzyl-p-toluenesulphonamide for EDL, blebbistatin for soleus) and muscle heat production was used as an index of Ca(2+) pump ATP turnover. At 20°C, Ca(2+) release in response to a single stimulus was 34 and 84 μmol (kg muscle)(-1) for soleus and EDL, respectively, and increased with temperature (30°C: soleus, 61 μmol kg(-1); EDL, 168 μmol kg(-1)). Delivery of another stimulus within 100 ms of the first produced a smaller Ca(2+) release. The maximum magnitude of the decrease in Ca(2+) release was greater in EDL than soleus. Ca(2+) release recovered with an exponential time course which was faster in EDL (mean time constant at 20°C, 32.1 ms) than soleus (65.6 ms) and faster at 30°C than at 20°C. The amounts of Ca(2+) released and crossbridge cycles performed are consistent with a scheme in which Ca(2+) binding to troponin-C allowed an average of ∼1.7 crossbridge cycles in the two muscles.

USA saadik loodab võita eestlaste poolehoiu / Joseph M. DeThomas

Index Scriptorium Estoniae

DeThomas, Joseph M.

2003-01-01

USA suursaadik Eestis Joseph DeThomas vastab on-line intervjuus Eesti Päevalehe lugejate küsimustele Iraagi ründamise, USA ja Euroopa vahelise lõhe, USA Eesti saatkonna võimaliku ümberkolimise kohta

Vaiksed professionaalid USA erivägedes on tulevased liidrid / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

USA eriüksuste juhid kinnitavad esiterrorist Osama bin Ladeni peatset tabamist. Floridas Tampas asuvast USA Lähis-Ida operatsioonide peastaabist. Lisa: USA erioperatsioonide keskused. Vt. samas: Ameerika pikk ja väsitav sõda

Measurements of natural 41Ca concentrations

International Nuclear Information System (INIS)

Steinhof, A.

1989-05-01

Atomic mass spectroscopic examinations on 41 Ca were carried out in the UNILAC accelerator. A sensitivity of about 10 -15 was achieved. This would allow the measurement of present natural 41 Ca concentrations as soon as the problem of the transmission determination is solved. In this respect suggestions were worked out and their feasibility discussed. The detection of 41 Ca-ions is especially free of background when high UNILAC-energies are applied. An estimation showed a background level corresponding with a 41 Ca concentration of less then 10 -17 referred to 40 Ca. Besides an independent concept for the electromagnetic concentration of 41 Ca with variable concentration factors was developed. After being concentrated up to 50 respectively 25 times the initial concentration in the GSI mass separator, the 41 Ca concentration of three recent deer bones found in the Odenwald was measured by atomic mass spectroscopy in the 14UD-Pelletron Tandem in Rehovot (Israel). The measured 41 Ca concentrations ranged between 10 -14 to 10 -13 with consideration of the concentration factor. A theoretical study of the 41 Ca production in the earth's surface based on cosmic radiation illustrates the influence of trace elements on the neutron flux and thus on the 41 Ca production. This influence might be a possible explanation for the observed amplitude of variation of the 41 Ca concentration in recent bones which are of decisive importance for the feasibility of 41 Ca-related dating. In this work a method is suggested that does not depend on the amplitude of variation mentioned above and which would allow the determination of the erosion rate of rocks by its 41 Ca concentrations. (orig./HP) [de

Bax regulates neuronal Ca2+ homeostasis.

Science.gov (United States)

D'Orsi, Beatrice; Kilbride, Seán M; Chen, Gang; Perez Alvarez, Sergio; Bonner, Helena P; Pfeiffer, Shona; Plesnila, Nikolaus; Engel, Tobias; Henshall, David C; Düssmann, Heiko; Prehn, Jochen H M

2015-01-28

Excessive Ca(2+) entry during glutamate receptor overactivation ("excitotoxicity") induces acute or delayed neuronal death. We report here that deficiency in bax exerted broad neuroprotection against excitotoxic injury and oxygen/glucose deprivation in mouse neocortical neuron cultures and reduced infarct size, necrotic injury, and cerebral edema formation after middle cerebral artery occlusion in mice. Neuronal Ca(2+) and mitochondrial membrane potential (Δψm) analysis during excitotoxic injury revealed that bax-deficient neurons showed significantly reduced Ca(2+) transients during the NMDA excitation period and did not exhibit the deregulation of Δψm that was observed in their wild-type (WT) counterparts. Reintroduction of bax or a bax mutant incapable of proapoptotic oligomerization equally restored neuronal Ca(2+) dynamics during NMDA excitation, suggesting that Bax controlled Ca(2+) signaling independently of its role in apoptosis execution. Quantitative confocal imaging of intracellular ATP or mitochondrial Ca(2+) levels using FRET-based sensors indicated that the effects of bax deficiency on Ca(2+) handling were not due to enhanced cellular bioenergetics or increased Ca(2+) uptake into mitochondria. We also observed that mitochondria isolated from WT or bax-deficient cells similarly underwent Ca(2+)-induced permeability transition. However, when Ca(2+) uptake into the sarco/endoplasmic reticulum was blocked with the Ca(2+)-ATPase inhibitor thapsigargin, bax-deficient neurons showed strongly elevated cytosolic Ca(2+) levels during NMDA excitation, suggesting that the ability of Bax to support dynamic ER Ca(2+) handling is critical for cell death signaling during periods of neuronal overexcitation. Copyright © 2015 the authors 0270-6474/15/351706-17$15.00/0.

Structural basis for the differential effects of CaBP1 and calmodulin on CaV1.2 calcium-dependent inactivation

Science.gov (United States)

Findeisen, Felix; Minor, Daniel L.

2010-01-01

Calcium-binding protein 1 (CaBP1), a calmodulin (CaM) homolog, endows certain voltage-gated calcium channels (CaVs) with unusual properties. CaBP1 inhibits CaV1.2 calcium-dependent inactivation (CDI) and introduces calcium-dependent facilitation (CDF). Here, we show that the ability of CaBP1 to inhibit CaV1.2 CDI and induce CDF arises from interaction between the CaBP1 N-lobe and interlobe linker residue Glu94. Unlike CaM, where functional EF hands are essential for channel modulation, CDI inhibition does not require functional CaBP1 EF-hands. Furthermore, CaBP1-mediated CDF has different molecular requirements than CaM-mediated CDF. Overall, the data show that CaBP1 comprises two structural modules having separate functions: similar to CaM, the CaBP1 C-lobe serves as a high-affinity anchor that binds the CaV1.2 IQ domain at a site that overlaps with the Ca2+/CaM C-lobe site, whereas the N-lobe/linker module houses the elements required for channel modulation. Discovery of this division provides the framework for understanding how CaBP1 regulates CaVs. PMID:21134641

Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation.

Science.gov (United States)

Findeisen, Felix; Minor, Daniel L

2010-12-08

Calcium-binding protein 1 (CaBP1), a calmodulin (CaM) homolog, endows certain voltage-gated calcium channels (Ca(V)s) with unusual properties. CaBP1 inhibits Ca(V)1.2 calcium-dependent inactivation (CDI) and introduces calcium-dependent facilitation (CDF). Here, we show that the ability of CaBP1 to inhibit Ca(V)1.2 CDI and induce CDF arises from interaction between the CaBP1 N-lobe and interlobe linker residue Glu94. Unlike CaM, where functional EF hands are essential for channel modulation, CDI inhibition does not require functional CaBP1 EF hands. Furthermore, CaBP1-mediated CDF has different molecular requirements than CaM-mediated CDF. Overall, the data show that CaBP1 comprises two structural modules having separate functions: similar to CaM, the CaBP1 C-lobe serves as a high-affinity anchor that binds the Ca(V)1.2 IQ domain at a site that overlaps with the Ca²+/CaM C-lobe site, whereas the N-lobe/linker module houses the elements required for channel modulation. Discovery of this division provides the framework for understanding how CaBP1 regulates Ca(V)s. Copyright © 2010 Elsevier Ltd. All rights reserved.

Elementary properties of CaV1.3 Ca2+ channels expressed in mouse cochlear inner hair cells

Science.gov (United States)

Zampini, Valeria; Johnson, Stuart L; Franz, Christoph; Lawrence, Neil D; Münkner, Stefan; Engel, Jutta; Knipper, Marlies; Magistretti, Jacopo; Masetto, Sergio; Marcotti, Walter

2010-01-01

Mammalian cochlear inner hair cells (IHCs) are specialized to process developmental signals during immature stages and sound stimuli in adult animals. These signals are conveyed onto auditory afferent nerve fibres. Neurotransmitter release at IHC ribbon synapses is controlled by L-type CaV1.3 Ca2+ channels, the biophysics of which are still unknown in native mammalian cells. We have investigated the localization and elementary properties of Ca2+ channels in immature mouse IHCs under near-physiological recording conditions. CaV1.3 Ca2+ channels at the cell pre-synaptic site co-localize with about half of the total number of ribbons present in immature IHCs. These channels activated at about −70 mV, showed a relatively short first latency and weak inactivation, which would allow IHCs to generate and accurately encode spontaneous Ca2+ action potential activity characteristic of these immature cells. The CaV1.3 Ca2+ channels showed a very low open probability (about 0.15 at −20 mV: near the peak of an action potential). Comparison of elementary and macroscopic Ca2+ currents indicated that very few Ca2+ channels are associated with each docked vesicle at IHC ribbon synapses. Finally, we found that the open probability of Ca2+ channels, but not their opening time, was voltage dependent. This finding provides a possible correlation between presynaptic Ca2+ channel properties and the characteristic frequency/amplitude of EPSCs in auditory afferent fibres. PMID:19917569

Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells.

Science.gov (United States)

Zampini, Valeria; Johnson, Stuart L; Franz, Christoph; Lawrence, Neil D; Münkner, Stefan; Engel, Jutta; Knipper, Marlies; Magistretti, Jacopo; Masetto, Sergio; Marcotti, Walter

2010-01-01

Mammalian cochlear inner hair cells (IHCs) are specialized to process developmental signals during immature stages and sound stimuli in adult animals. These signals are conveyed onto auditory afferent nerve fibres. Neurotransmitter release at IHC ribbon synapses is controlled by L-type Ca(V)1.3 Ca(2+) channels, the biophysics of which are still unknown in native mammalian cells. We have investigated the localization and elementary properties of Ca(2+) channels in immature mouse IHCs under near-physiological recording conditions. Ca(V)1.3 Ca(2+) channels at the cell pre-synaptic site co-localize with about half of the total number of ribbons present in immature IHCs. These channels activated at about 70 mV, showed a relatively short first latency and weak inactivation, which would allow IHCs to generate and accurately encode spontaneous Ca(2+) action potential activity characteristic of these immature cells. The Ca(V)1.3 Ca(2+) channels showed a very low open probability (about 0.15 at 20 mV: near the peak of an action potential). Comparison of elementary and macroscopic Ca(2+) currents indicated that very few Ca(2+) channels are associated with each docked vesicle at IHC ribbon synapses. Finally, we found that the open probability of Ca(2+) channels, but not their opening time, was voltage dependent. This finding provides a possible correlation between presynaptic Ca(2+) channel properties and the characteristic frequency/amplitude of EPSCs in auditory afferent fibres.

S&P: meie kohus oli USA riigireitingut alandada / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2011-01-01

Standard & Poor´s langetas USA reitingut tasemelt AAA tasemeni AA+. Agentuuri esindaja sõnul oli reitingu alandamine nende kohustus, sest nende arvates oli USA senine reiting liiga kõrge. Hiina nõuab, et USA hakkaks oma võlaprobleemiga tegelema. AAA reiting on nüüd vaid 15 riigil või territooriumil maailmas

EL taotleb USA-lt viisavabaduse võrdsust / Ahto Lobjakas, Anneli Ammas

Index Scriptorium Estoniae

Lobjakas, Ahto, 1970-

2004-01-01

Euroopa Komisjon soovib, et USA kiirendaks EL-i uute liikmesriikide kaasamist oma viisavabastusprogrammi. USA peab illegaalseid tööotsijaid üheks peamiseks tõkkeks viisavabaduse saavutamise teel. Kriteeriumidest, millele peavad USA-ga viisavabadust taotlevad riigid vastama

Electronic structures and magnetism of CaFeAsH and CaFeAsF

International Nuclear Information System (INIS)

Wang Guangtao; Shi Xianbiao; Liu Haipeng; Liu Qingbo

2015-01-01

We studied the electronic structures, magnetism, and Fermi surface (FS) nesting of CaFeAsH and CaFeAsF by first-principles calculations. In the nonmagnetic (NM) states, we found strong FS nesting, which induces magnetic instability and a spin density wave (SDW). Our calculations indicate that the ground state of CaFeAsH and CaFeAsF is the stripe antiferromagnetic state. The calculated bare susceptibility χ 0 (q) peaked at the M-point and was clearly suppressed and became slightly incommensurate with both electron doping and hole doping for both materials. (author)

The birth and growth of neuroradiology in the USA

International Nuclear Information System (INIS)

Gutierrez, C.; Goettingen Univ. Germany, F.R. Klinik fuer Neurochirurgie)

1981-01-01

Neuroradiology in the USA was started by the neurosurgeons Harvey Cushing, who personally made the first X-rays used to treat a patient with a neurological disability, and Walter Dandy, who first performed air ventriculography, ventriculoscopy, air encephalography and air myelography. The father of neuroradiology in the USA was Merrill Sosman, Cushing's associate. Modern neuroradiology was introduced into the USA from Europe by Mannie Schechter who was one of the original team of three Chief Editors of Neuroradiology. (orig.)

Physical conditions in CaFe interstellar clouds

OpenAIRE

Gnacinski, P.; Krogulec, M.

2007-01-01

Interstellar clouds that exhibit strong Ca I and Fe I lines were called CaFe clouds. The ionisation equilibrium equations were used to model the column densities of Ca II, Ca I, K I, Na I, Fe I and Ti II in CaFe clouds. The chemical composition of CaFe clouds is that of the Solar System and no depletion of elements onto dust grains is seen. The CaFe clouds have high electron densities n=1 cm^-3 that leads to high column densities of neutral Ca and Fe.

Ca 3d unoccupied states in Bi2Sr2CaCu2O8 investigated by Ca L2,3 x-ray-absorption near-edge structure

International Nuclear Information System (INIS)

Borg, A.; King, P.L.; Pianetta, P.; Lindau, I.; Mitzi, D.B.; Kapitulnik, A.; Soldatov, A.V.; Della Longa, S.; Bianconi, A.

1992-01-01

The high-resolution Ca L 2,3 x-ray-absorption near-edge-structure (XANES) spectrum of a Bi 2 Sr 2 CaCu 2 O 8 single crystal has been measured by use of a magnetic-projection x-ray microscope probing a surface area of 200x200 μm 2 . The Ca L 2,3 XANES spectrum is analyzed by performing a multiple-scattering XANES calculation in real space and comparing the results with the spectrum of CaF 2 . Good agreement between the calculated and experimental crystal-field splitting Δ f of the Ca 3d final states is found and the splitting is shown to be smaller by 0.5 eV than in the initial state. The Ca 3d partial density of states is found to be close to the Fermi level in the initial state. The Ca-O(in plane) distance is shown to be a critical parameter associated with the shift of the Ca 3d states relative to the Fermi level; in particular, we have studied the effect of the out-of-plane dimpling mode of the in-plane oxygen atoms O(in plane) that will move the Ca 3d states on or off the Fermi level. This mode can therefore play a role in modulating the charge transfer between the two CuO 2 planes separated by the Ca ions

Ca 3d unoccupied states in Bi2Sr2CaCu2O8 investigated by Ca L2,3 x-ray-absorption near-edge structure

Energy Technology Data Exchange (ETDEWEB)

Borg, A; King, P L; Pianetta, P; Lindau, I; Mitzi, D B

1992-01-01

The high-resolution Ca L(2,3) x-ray-absorption near-edge-structure (XANES) spectrum of a Bi2Sr2CaCu2O8 single crystal has been measured by use of a magnetic-projection x-ray microscope probing a surface area of 200x200 micrometers square. The Ca L(2,3) XANES spectrum is analyzed by performing a multiple-scattering XANES calculation in real space and comparing the results with the spectrum of CaF2. Good agreement between the calculated and experimental crystal-field splitting Delta f of the Ca 3d final states is found and the splitting is shown to be smaller by 0.5 eV than in the initial state. The Ca 3d partial density of states is found to be close to the Fermi level in the initial state. The Ca-O (in plane) distance is shown to be a critical parameter associated with the shift of the Ca 3d states relative to the Fermi level; in particular, the authors have studied the effect of the out-of-plane dimpling mode of the in-plane oxygen atoms O(in plane) that will move the Ca 3d states on or off the Fermi level. This mode can therefore play a role in modulating the charge transfer between the two CuO2 planes separated by the Ca ions.

77 FR 19719 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

Science.gov (United States)

2012-04-02

..., Leggett Nicholasville, KY..... February 16, 2011. & Platt, Inc.. 81,350 Fashion Ability Inc........ New... Location Impact date 81,190 Graphic Packaging Lawrenceburg, TN...... International, Consumer Packaging...

Controls over δ44/40Ca and Sr/Ca variations in coccoliths: New perspectives from laboratory cultures and cellular models

Science.gov (United States)

Mejía, Luz María; Paytan, Adina; Eisenhauer, Anton; Böhm, Florian; Kolevica, Ana; Bolton, Clara; Méndez-Vicente, Ana; Abrevaya, Lorena; Isensee, Kirsten; Stoll, Heather

2018-01-01

Coccoliths comprise a major fraction of the global carbonate sink. Therefore, changes in coccolithophores' Ca isotopic fractionation could affect seawater Ca isotopic composition, affecting interpretations of the global Ca cycle and related changes in seawater chemistry and climate. Despite this, a quantitative interpretation of coccolith Ca isotopic fractionation and a clear understanding of the mechanisms driving it are not yet available. Here, we address this gap in knowledge by developing a simple model (CaSri-Co) to track coccolith Ca isotopic fractionation during cellular Ca uptake and allocation to calcification. We then apply it to published and new δ 44 / 40 Ca and Sr/Ca data of cultured coccolithophores of the species Emiliania huxleyi and Gephyrocapsa oceanica. We identify changes in calcification rates, Ca retention efficiency and solvation-desolvation rates as major drivers of the Ca isotopic fractionation and Sr/Ca variations observed in cultures. Higher calcification rates, higher Ca retention efficiencies and lower solvation-desolvation rates increase both coccolith Ca isotopic fractionation and Sr/Ca. Coccolith Ca isotopic fractionation is most sensitive to changes in solvation-desolvation rates. Changes in Ca retention efficiency may be a major driver of coccolith Sr/Ca variations in cultures. We suggest that substantial changes in the water structure strength caused by past changes in temperature could have induced significant changes in coccolithophores' Ca isotopic fractionation, potentially having some influence on seawater Ca isotopic composition. We also suggest a potential effect on Ca isotopic fractionation via modification of the solvation environment through cellular exudates, a hypothesis that remains to be tested.

In-situ thermal analysis and macroscopical characterization of Mg-xCa and Mg-0.5Ca-xZn alloy systems

Energy Technology Data Exchange (ETDEWEB)

Farahany, Saeed [Department of Materials Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Bakhsheshi-Rad, Hamid Reza, E-mail: Rezabakhsheshi@gmail.com [Department of Materials Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Idris, Mohd Hasbullah [Department of Materials Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Abdul Kadir, Mohammed Rafiq [Medical Implants Technology Group, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Department of Biomechanics and Biomedical Materials, Faculty of Biomedical Engineering and Health Sciences, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Lotfabadi, Amir Fereidouni [Department of Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Ourdjini, Ali [Department of Materials Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia)

2012-01-10

Highlights: Black-Right-Pointing-Pointer The effect of Ca and Zn addition on Mg-Ca and Mg-Ca-Zn were investigated. Black-Right-Pointing-Pointer Ca and Zn addition decreased solid fraction at coherency point. Black-Right-Pointing-Pointer T{sub N}-T{sub DCP} increased by adding Ca and Zn in Mg-Ca and Mg-Ca-Zn, respectively. Black-Right-Pointing-Pointer Three reactions were detected when Zn/Ca atomic ratio less than 1.25 in Mg-Ca-Zn. Black-Right-Pointing-Pointer A new peak Mg{sub 51}Zn{sub 20} was identified in Mg-0.5Ca-9Zn in addition of other peaks. - Abstract: This research described the identification phases by thermal analysis and microscopy inspection of Mg-xCa and Mg-0.5%Ca-xZn alloys that were solidified at slow cooling rate. Analysis of cooling curve after Ca addition shows the evolution of the Mg{sub 2}Ca intermetallic phase at around 520 Degree-Sign C in addition to {alpha}-Mg phase. First derivative curves of alloys after the addition of Zn to Mg-0.5Ca alloy reveals three peaks related to {alpha}-Mg, Mg{sub 2}Ca and Ca{sub 2}Mg{sub 6}Zn{sub 3} for alloys that have Zn/Ca atomic ratio less than 1.23. The peak of Mg{sub 2}Ca reaction on the first derivative curves disappeared for alloys containing Zn/Ca ratio more than 1.23. A new peak was also observed at 330 Degree-Sign C for Mg-0.5Ca-9Zn which was identified as Mg{sub 51}Zn{sub 20}. Solid fraction at coherency point decreased with increasing Ca and Zn elements. However, coherency time and difference between the nucleation and coherency temperatures (T{sub N}-T{sub DCP}) increased by adding Ca and Zn in Mg-Ca and Mg-Ca-Zn systems.

Simultaneous Ka-Band Site Characterization: Goldstone, CA, White Sands, NM, and Guam, USA

Science.gov (United States)

Acosta, Roberto; Morse, Jacquelynne; Zemba, Michael; Nessel, James; Morabito, David; Caroglanian, Armen

2011-01-01

To statistically characterize atmospheric effects on Ka-band links at NASA operational sites, NASA has constructed site test interferometers (STI s) which directly measure the tropospheric phase stability and rain attenuation. These instruments observe an unmodulated beacon signal broadcast from a geostationary satellite (e.g., Anik F2) and measure the phase difference between the signals received by the two antennas and its signal attenuation. Three STI s have been deployed so far: the first one at the NASA Deep Space Network Tracking Complex in Goldstone, California (May 2007); the second at the NASA White Sands Complex, in Las Cruses, New Mexico (February 2009); and the third at the NASA Tracking and Data Relay Satellite (TDRS) Remote Ground Terminal (GRGT) complex in Guam (May 2010). Two station-years of simultaneous atmospheric phase fluctuation data have been collected at Goldstone and White Sands, while one year of data has been collected in Guam. With identical instruments operating simultaneously, we can directly compare the phase stability and rain attenuation at the three sites. Phase stability is analyzed statistically in terms of the root-mean-square (rms) of the tropospheric induced time delay fluctuations over 10 minute blocks. For two years, the time delay fluctuations at the DSN site in Goldstone, CA, have been better than 2.5 picoseconds (ps) for 90% of the time (with reference to zenith), meanwhile at the White Sands, New Mexico site, the time delay fluctuations have been better than 2.2 ps with reference to zenith) for 90% of time. For Guam, the time delay fluctuations have been better than 12 ps (reference to zenith) at 90% of the time, the higher fluctuations are as expected from a high humidity tropical rain zone. This type of data analysis, as well as many other site quality characteristics (e.g., rain attenuation, infrastructure, etc.) will be used to determine the suitability of all the sites for NASA s future communication services at Ka-band.

Synthesis of Al₂Ca Dispersoids by Powder Metallurgy Using a Mg-Al Alloy and CaO Particles.

Science.gov (United States)

Fujita, Junji; Umeda, Junko; Kondoh, Katsuyoshi

2017-06-28

The elemental mixture of Mg-6 wt %Al-1 wt %Zn-0.3 wt %Mn (AZ61B) alloy powder and CaO particles was consolidated by an equal-channel angular bulk mechanical alloying (ECABMA) process to form a composite precursor. Subsequently, the precursor was subjected to a heat treatment to synthesize fine Al₂Ca particles via a solid-state reaction between the Mg-Al matrix and CaO additives. Scanning electron microscopy-energy-dispersive spectroscopy (SEM-EDS) and electron probe micro-analysis on the precursor indicated that 4.7-at % Al atoms formed a supersaturated solid solution in the α-Mg matrix. Transmission electron microscopy-EDS and X-ray diffraction analyses on the AZ61B composite precursor with 10-vol % CaO particles obtained by heat treatment confirmed that CaO additives were thermally decomposed in the Mg-Al alloy, and the solid-soluted Ca atoms diffused along the α-Mg grain boundaries. Al atoms also diffused to the grain boundaries because of attraction to the Ca atoms resulting from a strong reactivity between Al and Ca. As a result, needle-like (Mg,Al)₂Ca intermetallics were formed as intermediate precipitates in the initial reaction stage during the heat treatment. Finally, the precipitates were transformed into spherical Al₂Ca particles by the substitution of Al atoms for Mg atoms in (Mg,Al)₂Ca after a long heat treatment.

βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses.

Science.gov (United States)

Borgesius, Nils Z; van Woerden, Geeske M; Buitendijk, Gabrielle H S; Keijzer, Nanda; Jaarsma, Dick; Hoogenraad, Casper C; Elgersma, Ype

2011-07-13

The calcium/calmodulin-dependent kinase type II (CaMKII) holoenzyme of the forebrain predominantly consists of heteromeric complexes of the αCaMKII and βCaMKII isoforms. Yet, in contrast to αCaMKII, the role of βCaMKII in hippocampal synaptic plasticity and learning has not been investigated. Here, we compare two targeted Camk2b mouse mutants to study the role of βCaMKII in hippocampal function. Using a Camk2b(-/-) mutant, in which βCaMKII is absent, we show that both hippocampal-dependent learning and Schaffer collateral-CA1 long-term potentiation (LTP) are highly dependent upon the presence of βCaMKII. We further show that βCaMKII is required for proper targeting of αCaMKII to the synapse, indicating that βCaMKII regulates the distribution of αCaMKII between the synaptic pool and the adjacent dendritic shaft. In contrast, localization of αCaMKII, hippocampal synaptic plasticity and learning were unaffected in the Camk2b(A303R) mutant, in which the calcium/calmodulin-dependent activation of βCaMKII is prevented, while the F-actin binding and bundling property is preserved. This indicates that the calcium/calmodulin-dependent kinase activity of βCaMKII is fully dispensable for hippocampal learning, LTP, and targeting of αCaMKII, but implies a critical role for the F-actin binding and bundling properties of βCaMKII in synaptic function. Together, our data provide compelling support for a model of CaMKII function in which αCaMKII and βCaMKII act in concert, but with distinct functions, to regulate hippocampal synaptic plasticity and learning.

Impact of seawater [Ca2+] on the calcification and calcite Mg / Ca of Amphistegina lessonii

NARCIS (Netherlands)

Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G. J.; de Nooijer, L. J.; Bijma, J.

2015-01-01

Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

CaWRKY22 Acts as a Positive Regulator in Pepper Response to Ralstonia Solanacearum by Constituting Networks with CaWRKY6, CaWRKY27, CaWRKY40, and CaWRKY58

OpenAIRE

Ansar Hussain; Xia Li; Yahong Weng; Zhiqin Liu; Muhammad Furqan Ashraf; Ali Noman; Sheng Yang; Muhammad Ifnan; Shanshan Qiu; Yingjie Yang; Deyi Guan; Shuilin He

2018-01-01

The WRKY web, which is comprised of a subset of WRKY transcription factors (TFs), plays a crucial role in the regulation of plant immunity, however, the mode of organization and operation of this network remains obscure, especially in non-model plants such as pepper (Capsicum annuum). Herein, CaWRKY22, a member of a subgroup of IIe WRKY proteins from pepper, was functionally characterized in pepper immunity against Ralstonia Solanacearum. CaWRKY22 was found to target the nuclei, and its trans...

Energy conservation in ICT-businesses. Green computing in the USA; Energiereductie topprioriteit ICT-bedrijven. Green computing is hot in de USA

Energy Technology Data Exchange (ETDEWEB)

Hulsebos, M.

2007-09-15

A brief overview of the initiatives in ICT-businesses in the USA to save energy, also known as 'green computing'. [Dutch] Een kort overzicht van de initiatieven bij ICT-bedrijven in de USA om energie te besparen, ook bekend onder de naam 'green computing'.

USA : rünnak võib olla parim kaitse / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

USA uues rahvusliku julgeoleku strateegias rõhutatakse, et tuumaambitsioonidega Iraak kujutab USA jaoks suurimat strateegilist väljakutset ning märgitakse, et teatud juhtudel on ohtude ennetamiseks vajalik jõu kasutamine. Vt. samas: Ameeriklaste toetus Iraagi sõjale väheneb. Lisa: Pessimistlik USA

Studies of highly ionized atoms using internal conversion: 197Au, 57Fe; electric monopole transitions in 40Ca, 42Ca, and 44Ca

International Nuclear Information System (INIS)

Ulrickson, M.A.

1975-01-01

By using heavy-ion reactions, highly ionized electronic states of atoms may be produced. The interaction between excited nuclear levels and the surrounding atomic electrons via internal conversion allows the nucleus to be used as a probe of the electronic structure of the highly ionized atoms. Studies of such atoms were undertaken for strongly internally converted nuclear levels in 197 Au and 57 Fe. The nuclear levels were Coulomb excited by using 16 O and 32 S beams. Simultaneous measurement of the lifetime of the 77-keV state of 197 Au in both neutral gold atoms and gold atoms with mean charge +10 resulted in a measured change in the internal conversion coefficient of Δalpha/alpha equals - 1.7 +- 3.0)10 -3 . This result is consistent with calculations using a Hartree-Fock--Slater program. Measurements of the electric monopole strengths for 0 + → 0 + transitions were undertaken to determine the amount of core-deformation in calcium nuclei. The E0 strengths for the decays of the 0 + states at 5.21 MeV in 40 C, 1.84 MeV in 42 Ca, and 1.88 MeV in 44 Ca were observed. The branching ratios for the subsequent E0 pair decays were measured by observing the coincident annihilation radiation from the e + member of the pair in coincidence with protons feeding the state in the cases of 42 Ca and 44 Ca, and by observing the actual coincident e + --e - pair together with protons feeding the state in the case of 40 Ca. The resulting E0 strengths (rho less than or equal to 0.06, rho = 0.34 +- 0.03, rho = 0.30 +- 0.10 for 40 Ca, 42 Ca, and 44 Ca respectively) agree with theoretical descriptions

USA salajane riigiametnike komisjon võib panna ka oma kodanikud tapanimekirja / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2011-01-01

Jeemenis USA droonirünnakus hukkunud Anwar al-Awlaki, keda USA valitsusesindajad nimetasid al-Qaida talendiotsijaks ja värvatute motiveerijaks, oli väidetavalt esimene USA kodanik, kes oli pandud USA vastu võitlevate terroristide nn. tapanimekirja

Structural and compositional characterization of synthetic (Ca,Sr)-tremolite and (Ca,Sr)-diopside solid solutions

Science.gov (United States)

Gottschalk, M.; Najorka, J.; Andrut, M.

Tremolite (CaxSr1-x)2Mg5[Si8O22/(OH)2] and diopside (CaxSr1-x)Mg[Si2O6] solid solutions have been synthesized hydrothermally in equilibrium with a 1 molar (Ca,Sr)Cl2 aqueous solution at 750°C and 200 MPa. The solid run products have been investigated by optical, electron scanning and high resolution transmission electron microscopy, electron microprobe, X-ray-powder diffraction and Fourier-transform infrared spectroscopy. The synthesized (Ca,Sr)-tremolites are up to 2000 µm long and 30 µm wide, the (Ca,Sr)-diopsides are up to 150 µm long and 20 µm wide. In most runs the tremolites and diopsides are well ordered and chain multiplicity faults are rare. Nearly pure Sr-tremolite (tr0.02Sr-tr0.98) and Sr-diopside (di0.01Sr-di0.99) have been synthesized. A continuous solid solution series, i.e. complete substitution of Sr2+ for Ca2+ on M4-sites exists for (Ca,Sr)-tremolite. Total substitution of Sr2+ for Ca2+ on M2-sites can be assumed for (Ca,Sr)-diopsides. For (Ca,Sr)-tremolites the lattice parameters a, b and β are linear functions of composition and increase with Sr-content whereas c is constant. For the diopside series all 4 lattice parameters are a linear function of composition; a, b, c increase and β decreases with rising Sr-content. The unit cell volume for tremolite increases 3.47% from 906.68 Å3 for tremolite to 938.21 Å3 for Sr-tremolite. For diopside the unit cell volume increases 4.87 % from 439.91 Å3 for diopside to 461.30 Å3 for Sr-diopside. The observed splitting of the OH stretching band in tremolite is caused by different configurations of the next nearest neighbors (multi mode behavior). Resolved single bands can be attributed to the following configurations on the M4-sites: SrSr, SrCa, CaCa and CaMg. The peak positions of these 4 absorption bands are a linear function of composition. They are shifted to lower wavenumbers with increasing Sr-content. No absorption band due to the SrMg configuration on the M4-site is observed. This indicates

Formation of CaB6 in the thermal decomposition of the hydrogen storage material Ca(BH4)2.

Science.gov (United States)

Sahle, Christoph J; Sternemann, Christian; Giacobbe, Carlotta; Yan, Yigang; Weis, Christopher; Harder, Manuel; Forov, Yury; Spiekermann, Georg; Tolan, Metin; Krisch, Michael; Remhof, Arndt

2016-07-20

Using a combination of high resolution X-ray powder diffraction and X-ray Raman scattering spectroscopy at the B K- and Ca L2,3-edges, we analyzed the reaction products of Ca(BH4)2 after annealing at 350 °C and 400 °C under vacuum conditions. We observed the formation of nanocrystalline/amorphous CaB6 mainly and found only small contributions from amorphous B for annealing times larger than 2 h. For short annealing times of 0.5 h at 400 °C we observed neither CaB12H12 nor CaB6. The results indicate a reaction pathway in which Ca(BH4)2 decomposes to B and CaH2 and finally reacts to form CaB6. These findings confirm the potential of using Ca(BH4)2 as a hydrogen storage medium and imply the desired cycling capabilities for achieving high-density hydrogen storage materials.

Ca2+/Calmodulin-Dependent Protein Kinase Kinases (CaMKKs) Effects on AMP-Activated Protein Kinase (AMPK) Regulation of Chicken Sperm Functions.

Science.gov (United States)

Nguyen, Thi Mong Diep; Combarnous, Yves; Praud, Christophe; Duittoz, Anne; Blesbois, Elisabeth

2016-01-01

Sperm require high levels of energy to ensure motility and acrosome reaction (AR) accomplishment. The AMP-activated protein kinase (AMPK) has been demonstrated to be strongly involved in the control of these properties. We address here the question of the potential role of calcium mobilization on AMPK activation and function in chicken sperm through the Ca(2+)/calmodulin-dependent protein kinase kinases (CaMKKs) mediated pathway. The presence of CaMKKs and their substrates CaMKI and CaMKIV was evaluated by western-blotting and indirect immunofluorescence. Sperm were incubated in presence or absence of extracellular Ca(2+), or of CaMKKs inhibitor (STO-609). Phosphorylations of AMPK, CaMKI, and CaMKIV, as well as sperm functions were evaluated. We demonstrate the presence of both CaMKKs (α and β), CaMKI and CaMKIV in chicken sperm. CaMKKα and CaMKI were localized in the acrosome, the midpiece, and at much lower fluorescence in the flagellum, whereas CaMKKβ was mostly localized in the flagellum and much less in the midpiece and the acrosome. CaMKIV was only present in the flagellum. The presence of extracellular calcium induced an increase in kinases phosphorylation and sperm activity. STO-609 reduced AMPK phosphorylation in the presence of extracellular Ca(2+) but not in its absence. STO-609 did not affect CaMKIV phosphorylation but decreased CaMKI phosphorylation and this inhibition was quicker in the presence of extracellular Ca(2+) than in its absence. STO-609 efficiently inhibited sperm motility and AR, both in the presence and absence of extracellular Ca(2+). Our results show for the first time the presence of CaMKKs (α and β) and one of its substrate, CaMKI in different subcellular compartments in germ cells, as well as the changes in the AMPK regulation pathway, sperm motility and AR related to Ca(2+) entry in sperm through the Ca(2+)/CaM/CaMKKs/CaMKI pathway. The Ca(2+)/CaMKKs/AMPK pathway is activated only under conditions of extracellular Ca(2+) entry

Ca2+/Calmodulin-Dependent Protein Kinase Kinases (CaMKKs Effects on AMP-Activated Protein Kinase (AMPK Regulation of Chicken Sperm Functions.

Directory of Open Access Journals (Sweden)

Thi Mong Diep Nguyen

Full Text Available Sperm require high levels of energy to ensure motility and acrosome reaction (AR accomplishment. The AMP-activated protein kinase (AMPK has been demonstrated to be strongly involved in the control of these properties. We address here the question of the potential role of calcium mobilization on AMPK activation and function in chicken sperm through the Ca(2+/calmodulin-dependent protein kinase kinases (CaMKKs mediated pathway. The presence of CaMKKs and their substrates CaMKI and CaMKIV was evaluated by western-blotting and indirect immunofluorescence. Sperm were incubated in presence or absence of extracellular Ca(2+, or of CaMKKs inhibitor (STO-609. Phosphorylations of AMPK, CaMKI, and CaMKIV, as well as sperm functions were evaluated. We demonstrate the presence of both CaMKKs (α and β, CaMKI and CaMKIV in chicken sperm. CaMKKα and CaMKI were localized in the acrosome, the midpiece, and at much lower fluorescence in the flagellum, whereas CaMKKβ was mostly localized in the flagellum and much less in the midpiece and the acrosome. CaMKIV was only present in the flagellum. The presence of extracellular calcium induced an increase in kinases phosphorylation and sperm activity. STO-609 reduced AMPK phosphorylation in the presence of extracellular Ca(2+ but not in its absence. STO-609 did not affect CaMKIV phosphorylation but decreased CaMKI phosphorylation and this inhibition was quicker in the presence of extracellular Ca(2+ than in its absence. STO-609 efficiently inhibited sperm motility and AR, both in the presence and absence of extracellular Ca(2+. Our results show for the first time the presence of CaMKKs (α and β and one of its substrate, CaMKI in different subcellular compartments in germ cells, as well as the changes in the AMPK regulation pathway, sperm motility and AR related to Ca(2+ entry in sperm through the Ca(2+/CaM/CaMKKs/CaMKI pathway. The Ca(2+/CaMKKs/AMPK pathway is activated only under conditions of extracellular Ca(2

Dynamic immobilization of simulated radionuclide 133Cs in soil by thermal treatment/vitrification with nanometallic Ca/CaO composites

International Nuclear Information System (INIS)

Mallampati, Srinivasa Reddy; Mitoma, Yoshiharu; Okuda, Tetsuji; Simion, Cristian; Lee, Byeong Kyu

2015-01-01

Although direct radiation induced health impacts were considered benign, soil contamination with 137 Cs, due to its long-term radiological impact (30 years half-life) and its high biological availability is of a major concern in Japan in the aftermath of the Fukushima nuclear power plant disaster. Therefore 137 Cs reduction and immobilization in contaminated soil are recognized as important problems to be solved using suitable and effective technologies. One such thermal treatment/vitrification with nanometallic Ca/CaO amendments is a promising treatment for the ultimate immobilization of simulated radionuclide 133 Cs in soil, showing low leachability and zero evaporation. Immobilization efficiencies were 88%, 95% and 96% when the 133 Cs soil was treated at 1200 °C with activated carbon, fly ash and nanometallic Ca/CaO additives. In addition, the combination of nanometallic Ca/CaO and fly ash (1:1) enhanced the immobilization efficiency to 99%, while no evaporation of 133 Cs was observed. At lower temperatures (800 °C) the leachable fraction of Cs was only 6% (94% immobilization). Through the SEM–EDS analysis, decrease in the amount of Cs mass percent detectable on soil particle surface was observed after soil vitrified with nCa/CaO + FA. The 133 Cs soil was subjected to vitrified with nCa/CaO + FA peaks related to Ca, crystalline phases (CaCO 3 /Ca(OH) 2 ), wollastonite, pollucite and hematite appeared in addition to quartz, kaolinite and bentonite, which probably indicates that the main fraction of enclosed/bound materials includes Ca-associated complexes. Thus, the thermal treatment with the addition of nanometallic Ca/CaO and fly ash may be considered potentially applicable for the remediation of radioactive Cs contaminated soil at zero evaporation, relatively at low temperature. - Graphical abstract: SEM–EDS element maps of 133 Cs contaminated soil before and after thermal treatment at 1200 °C with different addictives. Color intensity for Cs is from 0

Anti-tumor activity of self-charged (Eu,Ca):WO3 and Eu:CaWO4 nanoparticles

International Nuclear Information System (INIS)

Lin, Cao; Cong, Wang; De'An, Pan; Jiexin, Cao; Ping, Che; Volinsky, Alex A.

2012-01-01

Non-stoichiometric (Eu,Ca):WO 3 and Eu:CaWO 4 nanoparticles with anti-tumor activity are synthesized in a sol-gel method by adding excessive Eu 3+ and Ca 2+ ions to tungsten oxide crystal structure. Colorimetric assay shows that 10 nm (Eu,Ca):WO 3 and Eu:CaWO 4 nanoparticles can effectively inhibit growth of mammary cancer cells without any harm to normal cells. Nanoparticles are characterized by X-ray diffraction, high resolution transmission electron microscopy and fluorescence optical spectrometry. Nanomaterials, insoluble in synthesized water, have complicated self-charging surfaces that trap mammary cancer cells. Surface self-charging effect is suggested as the inhibition mechanism. (author)

PGC-1{alpha} accelerates cytosolic Ca{sup 2+} clearance without disturbing Ca{sup 2+} homeostasis in cardiac myocytes

Energy Technology Data Exchange (ETDEWEB)

Chen, Min, E-mail: chenminyx@gmail.com [Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871 (China); Yunnan Centers for Diseases Prevention and Control, Kunming 650022 (China); Wang, Yanru [Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871 (China); Qu, Aijuan [Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States)

2010-06-11

Energy metabolism and Ca{sup 2+} handling serve critical roles in cardiac physiology and pathophysiology. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1{alpha}) is a multi-functional coactivator that is involved in the regulation of cardiac mitochondrial functional capacity and cellular energy metabolism. However, the regulation of PGC-1{alpha} in cardiac Ca{sup 2+} signaling has not been fully elucidated. To address this issue, we combined confocal line-scan imaging with off-line imaging processing to characterize calcium signaling in cultured adult rat ventricular myocytes expressing PGC-1{alpha} via adenoviral transduction. Our data shows that overexpressing PGC-1{alpha} improved myocyte contractility without increasing the amplitude of Ca{sup 2+} transients, suggesting that myofilament sensitivity to Ca{sup 2+} increased. Interestingly, the decay kinetics of global Ca{sup 2+} transients and Ca{sup 2+} waves accelerated in PGC-1{alpha}-expressing cells, but the decay rate of caffeine-elicited Ca{sup 2+} transients showed no significant change. This suggests that sarcoplasmic reticulum (SR) Ca{sup 2+}-ATPase (SERCA2a), but not Na{sup +}/Ca{sup 2+} exchange (NCX) contribute to PGC-1{alpha}-induced cytosolic Ca{sup 2+} clearance. Furthermore, PGC-1{alpha} induced the expression of SERCA2a in cultured cardiac myocytes. Importantly, overexpressing PGC-1{alpha} did not disturb cardiac Ca{sup 2+} homeostasis, because SR Ca{sup 2+} load and the propensity for Ca{sup 2+} waves remained unchanged. These data suggest that PGC-1{alpha} can ameliorate cardiac Ca{sup 2+} cycling and improve cardiac work output in response to physiological stress. Unraveling the PGC-1{alpha}-calcium handing pathway sheds new light on the role of PGC-1{alpha} in the therapy of cardiac diseases.

A critical comparison of the current view of Ca signaling with the novel concept of F-actin-based Ca signaling.

Science.gov (United States)

Lange, Klaus; Gartzke, Joachim

2006-01-01

A detailed comparative survey on the current idea of Ca signaling and the alternative concept of F-actin-based Ca signaling is given. The two hypotheses differ in one central aspect - the mechanism of Ca storage. The current theory rests on the assumption of Ca-accumulating vesicles derived from the endoplasmic/ sarcoplasmic reticulum, which are equipped with an ATP-dependent Ca pump and IP3- or ryanodine-sensitive Ca-release channels/receptors. The alternative hypothesis proceeds from the idea of Ca storage at the high-affinity binding sites of F-actin subunits. Several prominent features of Ca signaling, which are not adequately described by the current concept, are inherent properties of the F-actin system and its dynamic state of treadmilling. F-actin is the only known biological Ca-binding system that has been proven by in vitro experiments to work within the physiological range of Ca concentrations and the only system that meets all necessary conditions to function as receptor-operated Ca store and as a coupling device between the Ca store and the store-operated Ca influx pathway. The most important properties of Ca signaling, such as store-channel coupling, quantal Ca release, spiking and oscillations, biphasic and "phasic" uptake kinetics, and Ca-induced Ca release, turn out to be systematic features of the new concept but remain unexplained by the classical vesicle storage hypothesis. A number of novel findings, specifically recent reports about direct effects of actin-specific toxins on Ca stores, have strengthened the new concept. The concept of F-actin-based Ca signaling combined with the notion of microvillar regulation of ion and substrate fluxes opens new aspects and far-reaching consequences, not only for cellular Ca signaling but also for various other cell functions, and represents an opportunity to connect several fields of cell physiology on the basis of a common mechanism.

Study on Ca2+ antagonistic effect and mechanism of Chinese herbal drugs using 45Ca

International Nuclear Information System (INIS)

Yang Yuanyou; Liu Ning; Mo Shangwu; Qiu Mingfeng; Jin Jiannan; Liao Jiali

2002-01-01

The Ca 2+ antagonistic effect and mechanism of Chinese herbal drugs are studied by using 45 Ca. The results indicate that potential-dependent Ca 2+ channel (PDC) and receptor-operated Ca 2+ channel (ROC) in cell membranes of smooth muscle can be blocked by several Chinese herbal drugs, including as Crocus sativus L., Carthamus L., Di-ao-xin-xue-kang (DAXXG) and Ginkgo biloba L. leaves. Among them Crocus sativus L. has the strongest antagonistic effect on Ca 2+ channel, while Ginkgo biloba L. leaves has no obvious effect. The whole prescription and the other functional drugs have significant effect on ROC and PDC. The compositions extracted by hexane have the strongest antagonistic. The wrinkled giant hyssop have five active compositions and Pei-lan have two active compositions

Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus

Directory of Open Access Journals (Sweden)

Hawes Alicia C

2007-11-01

Full Text Available Abstract Background Community acquired (CA methicillin-resistant Staphylococcus aureus (MRSA increasingly causes disease worldwide. USA300 has emerged as the predominant clone causing superficial and invasive infections in children and adults in the USA. Epidemiological studies suggest that USA300 is more virulent than other CA-MRSA. The genetic determinants that render virulence and dominance to USA300 remain unclear. Results We sequenced the genomes of two pediatric USA300 isolates: one CA-MRSA and one CA-methicillin susceptible (MSSA, isolated at Texas Children's Hospital in Houston. DNA sequencing was performed by Sanger dideoxy whole genome shotgun (WGS and 454 Life Sciences pyrosequencing strategies. The sequence of the USA300 MRSA strain was rigorously annotated. In USA300-MRSA 2658 chromosomal open reading frames were predicted and 3.1 and 27 kilobase (kb plasmids were identified. USA300-MSSA contained a 20 kb plasmid with some homology to the 27 kb plasmid found in USA300-MRSA. Two regions found in US300-MRSA were absent in USA300-MSSA. One of these carried the arginine deiminase operon that appears to have been acquired from S. epidermidis. The USA300 sequence was aligned with other sequenced S. aureus genomes and regions unique to USA300 MRSA were identified. Conclusion USA300-MRSA is highly similar to other MRSA strains based on whole genome alignments and gene content, indicating that the differences in pathogenesis are due to subtle changes rather than to large-scale acquisition of virulence factor genes. The USA300 Houston isolate differs from another sequenced USA300 strain isolate, derived from a patient in San Francisco, in plasmid content and a number of sequence polymorphisms. Such differences will provide new insights into the evolution of pathogens.

Regional variation in the chemical composition of winter snow pack and terricolous lichens in relation to sources of acid emissions in the Usa river basin, northeast European Russia

International Nuclear Information System (INIS)

Walker, T.R.; Crittenden, P.D.; Young, S.D.

2003-01-01

The chemistry of winter snow pack and terricolous lichens indicate pollution distribution in Arctic Russia. - The chemical composition of snow and terricolous lichens was determined along transects through the Subarctic towns of Vorkuta (130 km west-east), Inta (240 km south-north) and Usinsk (140 km, southwest-northeast) in the Usa river basin, northeast European Russia. Evidence of pollution gradients was found on two spatial scales. First, on the Inta transect, northward decreases in concentrations of N in the lichen Cladonia stellaris (from 0.57 mmol N g -1 at 90 km south to 0.43 mmol N g -1 at 130 km north of Inta) and winter deposition of non-sea salt sulphate (from 29.3 to 12.8 mol ha -1 at 90 km south and 110 km north of Inta, respectively) were attributed to long range transport of N and S from lower latitudes. Second, increased ionic content (SO 4 2- , Ca 2+ , K + ) and pH of snow, and modified N concentration and the concentration ratios K + :Mg 2+ and K + : (Mg 2+ +Ca 2+ ) in lichens (Cladonia arbuscula and Flavocetraria cucullata) within ca. 25-40 km of Vorkuta and Inta were largely attributed to local deposition of alkaline coal ash. Total sulphate concentrations in snow varied from ca. 5 μmol l -1 at remote sites to ca. 19 μmol l -1 near Vorkuta. Nitrate concentration in snow (typically ca. 9 μmol l -1 ) did not vary with proximity to perceived pollution sources

Mg/Ca of Continental Ostracode Shells

Science.gov (United States)

Ito, E.; Forester, R. M.; Marco-Barba, J.; Mezquita, F.

2007-12-01

Marine ionic chemistry is thought to remain constant. This, together with the belief that marine calcifiers partition Mg/Ca in a systematic manner as functions of temperature (and Mg/Ca) of water forms the basis of the Mg/Ca thermometer. In continental settings both of these assumptions are usually not true. Continental waters contain a wide variety of solutes in absolute and relative ion concentrations. Hence, waters with identical Mg/Ca may have very different concentrations of Mg and Ca and very different anions. Here we use two examples to focus on the effects of ion chemistry on Mg/Ca partitioning in continental ostracode shells and we ignore the complexities of solute evolution, which can change Mg/Ca over timescales of minutes to millennia. Palacios-Fest and Dettman (2001) conducted a monthly study of ,Cypridopsis vidua at El Yeso Lake in Sonora, Mexico. They established a relation between temperature and average shell Mg/Ca using regression analyses on averaged data. When their Mg/Ca-temperature relation is applied to monthly ,C. vidua data from Page Pond near Cleveland, Ohio, water temperatures of -8 to -1°C are obtained. The observed Mg/Ca ranges for El Yeso Lake (0.31 to 0.46) and Page Pond (0.33 to 0.46) are similar, as are their specific conductivities (700 to 850μS for El Yeso Lake; 400 to 600μS for Page Pond). However, [Ca] is 140-260 mg/L for El Yeso, but only 70-90 mg/L for Page Pond. Page Pond data, in fact, shows a good temperature shell Mg/Ca relation for .C. vidua, but the relation is different from that at El Yeso. Hence, shell Mg/Ca is a multi-valued, family of curves function of temperature and Mg/Ca of water that depends on the [Mg] and [Ca] values in water and perhaps other factors. Our second example comes from sites near Valencia, Spain and involves shell data for ,Cyprideis torosa, an estuarine ostracode that is tolerant of a wide range of salinity and can live in continental waters as long as the carbonate alkalinity to Ca ratio is

Pricing behavior of USA exporter in wheat international market

Science.gov (United States)

Wibowo, R. P.; Sumono; Iddrisu, Y.; Darus, M.; Sihombing, L. P.; Jufri

2018-02-01

The number of wheat producing countries is changing over time. It is expected the change in wheat supply will lead world wheat market become more competitive and reduce market power of major exporter country. This paper tries to identify and examined the degree of market power on wheat international market for USA by using the Pricing to Market (PTM) method. USA is the biggest producer and exporter in wheat market. The PTM method found that USA impose noncompetitive strategy by applying price discrimination and apply market power to their importer country.

Is otolith microchemistry (Sr: Ca and Ba:Ca ratios useful to identify Mugil curema populations in the southeastern Caribbean Sea?

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E. Avigliano

Full Text Available Abstract The aim of the present study was to evaluate the potential use of otolith microchemistry (Sr:Ca and Ba:Ca ratios to identify silver mullet, Mugil curema, populations in Southeastern Caribbean Sea. Fish samples were collected in 7 areas of Nueva Esparta State (Venezuela. The otolith Sr:Ca and Ba:Ca ratios and water Sr:Ca were determined (by ICP-OES and EDTA volumetric method. Otoliths Sr:Ca and Ba:Ca ratios and Sr:Ca partition coefficient of mullets in Cubagua island (south of the State were significantly different from ratios in La Guardia (north of the State. A discriminant analysis of otolith Sr:Ca and Ba:Ca ratios separated Cubagua Island from La Guardia values. These results suggest the existence of different mullet groups in the Southeastern Caribbean Sea. For this, the simultaneous use of Sr:Ca and Ba:Ca ratios could be a potential tool to identify populations in the study area.

Is otolith microchemistry (Sr: Ca and Ba:Ca ratios) useful to identify Mugil curema populations in the southeastern Caribbean Sea?

Science.gov (United States)

Avigliano, E; Callicó-Fortunato, R; Buitrago, J; Volpedo, A V

2015-11-01

The aim of the present study was to evaluate the potential use of otolith microchemistry (Sr:Ca and Ba:Ca ratios) to identify silver mullet, Mugil curema, populations in Southeastern Caribbean Sea. Fish samples were collected in 7 areas of Nueva Esparta State (Venezuela). The otolith Sr:Ca and Ba:Ca ratios and water Sr:Ca were determined (by ICP-OES and EDTA volumetric method). Otoliths Sr:Ca and Ba:Ca ratios and Sr:Ca partition coefficient of mullets in Cubagua island (south of the State) were significantly different from ratios in La Guardia (north of the State). A discriminant analysis of otolith Sr:Ca and Ba:Ca ratios separated Cubagua Island from La Guardia values. These results suggest the existence of different mullet groups in the Southeastern Caribbean Sea. For this, the simultaneous use of Sr:Ca and Ba:Ca ratios could be a potential tool to identify populations in the study area.

Role of Ca ++ Influx via Epidermal TRP Ion Channels

Science.gov (United States)

2016-10-01

the North Carolina Biotechnology Center (NCBC), and by the Harrington Discovery Institute of University Hospitals in Cleveland OH. 7   The...widely read forum on Pain Medicine in the US and in English-speaking countries. http://www.painmedicinenews.com/Science-Technology/Article/08-16/Study...University, Durham NC USA. 2Dept of Medicine , Duke University, Durham NC USA. 3Dept of Chemistry, Duke University, Durham NC USA. 4Dept of Neurobiology

The XXIIIrd Phage/Virus Assembly Meeting.

Science.gov (United States)

Serwer, Philip

2014-01-01

The XXIIIrd Phage/Virus Assembly (PVA) meeting returned to its birthplace in Lake Arrowhead, CA on September 8-13, 2013 (Fig. 1). The original meeting occurred in 1968, organized by Bob Edgar (Caltech, Pasadena, CA USA), Fred Eiserling (University of California, Los Angeles, Los Angeles, CA USA) and Bill Wood (Caltech, Pasadena, CA USA). The organizers of the 2013 meeting were Bill Gelbart (University of California, Los Angeles, Los Angeles, CA USA) and Jack Johnson (Scripps Research Institute, La Jolla, CA USA). This meeting specializes in an egalitarian format. Students are distinguished from senior faculty primarily by the signs of age. With the exception of historically based introductory talks, all talks were allotted the same time and freedom. This tradition began when the meeting was phage-only and has been continued now that all viruses are included. Many were the animated conversations about basic questions. New and international participants were present, a sign that the field has significant attraction, as it should, based on details below. The meeting was also characterized by a sense of humor and generally good times, a chance to both enjoy the science and forget the funding malaise to which many participants are exposed. I will present some of the meeting content, without attempting to be comprehensive.

Menstrual Cycle Dependent Variability for Serum Tumor Markers CEA, AFP, CA 19-9, CA 125 and CA 15-3 in Healthy Women

Directory of Open Access Journals (Sweden)

Ayşe Binnur Erbağci

1999-01-01

Full Text Available Information on menstrual cycle dependent variation of tumor markers in healthy women is a subject of diagnostic efficiency and has an impact in elucidating the normal function of these markers. In this study midfollicular and midluteal concentrations of serum CEA, AFP, CA 19-9, CA 125, CA 15-3 and their relations with LH, FSH, prolactin, estradiol and progesterone were evaluated during ovulatory cycles in a group of 23 healthy female individuals. Samples were collected on the 7th and 21st day of the same menstrual cycle. Tumor marker and hormone concentrations were determined with chemiluminescence or electrochemiluminescence EIA methods. A significant phase-dependent difference was observed for CA 15-3, midluteal concentrations (mean ± SEM; 26.33 ± 1.56 U/ml higher than the midfollicular (mean ± SEM; 19.27 ± 1.49 U/ml concentrations (p < 0.001. But an obvious difference for other tumor markers investigated did not exist. Significant correlations of follicular and luteal CA 125 levels with body mass index of the subjects were observed (r:0.52, p < 0.05 and r:0.57, p < 0.005, respectively.

Ca(AlH4)2, CaAlH5, and CaH2+6LiBH4: Calculated dehydrogenation enthalpy, including zero point energy, and the structure of the phonon spectra.

Science.gov (United States)

Marashdeh, Ali; Frankcombe, Terry J

2008-06-21

The dehydrogenation enthalpies of Ca(AlH(4))(2), CaAlH(5), and CaH(2)+6LiBH(4) have been calculated using density functional theory calculations at the generalized gradient approximation level. Harmonic phonon zero point energy (ZPE) corrections have been included using Parlinski's direct method. The dehydrogenation of Ca(AlH(4))(2) is exothermic, indicating a metastable hydride. Calculations for CaAlH(5) including ZPE effects indicate that it is not stable enough for a hydrogen storage system operating near ambient conditions. The destabilized combination of LiBH(4) with CaH(2) is a promising system after ZPE-corrected enthalpy calculations. The calculations confirm that including ZPE effects in the harmonic approximation for the dehydrogenation of Ca(AlH(4))(2), CaAlH(5), and CaH(2)+6LiBH(4) has a significant effect on the calculated reaction enthalpy. The contribution of ZPE to the dehydrogenation enthalpies of Ca(AlH(4))(2) and CaAlH(5) calculated by the direct method phonon analysis was compared to that calculated by the frozen-phonon method. The crystal structure of CaAlH(5) is presented in the more useful standard setting of P2(1)c symmetry and the phonon density of states of CaAlH(5), significantly different to other common complex metal hydrides, is rationalized.

Iraagis on surma saanud juba 2000 USA sõjaväelast / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2005-01-01

USA-s suri 2000. sõjaväelane Iraagis saadud haavadesse. Kui USA juhitud välismaiste relvajõudude esindaja Bagdadis kutsus meediat seda arvu mitte üle tähtsustama, siis USA meedia seevastu pidas seda just oluliseks märgiks. Diagrammid: Iraagi sõja inimkaotused

Low temperature synthesis of CaZrO3 nanoceramics from CaCl2–NaCl molten eutectic salt

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Rahman Fazli

2015-06-01

Full Text Available CaZrO3 nanoceramics were successfully synthesized at 700 C using the molten salt method, and the effects of processing parameters, such as temperature, holding time, and amount of salt on the crystallization of CaZrO3 were investigated. CaCl2, Na2CO3, and nano-ZrO2 were used as starting materials. On heating, CaCl2–NaCl molten eutectic salt provided a liquid medium for the reaction of CaCO3 and ZrO2 to form CaZrO3. The results demonstrated that CaZrO3 started to form at about 600C and that, after the temperature was increased to 1,000C, the amounts of CaZrO3 in the resultant powders increased with a concomitant decrease in CaCO3and ZrO2 contents. After washing with hot distilled water, the samples heated for 3 h at 700C were single-phase CaZrO3 with 90–95 nm particle size. Furthermore, the synthesized CaZrO3 particles retained the size and morphology of the ZrO2 powders which indicated that a template mechanism dominated the formation of CaZrO3 by molten-salt method.

USA kliimamuutuse vastu: Kopenhaagenis ja edaspidi / Michael C. Polt

Index Scriptorium Estoniae

Polt, Michael C., 1954-

2009-01-01

Käsitledes Kopenhaageni kliimakonverentsi, märgib USA Eesti-suursaadik, et USA on valmis paika panema eesmärgi vähendada kohalike seadustega kooskõlas 2020. aastaks kasvuhoonegaaside heitmete emissiooni tasemeni, mis oleks 17% väiksem 2005. aasta tasemest

Ablation of CaV2.1 Voltage-Gated Ca2+ Channels in Mouse Forebrain Generates Multiple Cognitive Impairments

Science.gov (United States)

Mallmann, Robert Theodor; Elgueta, Claudio; Sleman, Faten; Castonguay, Jan; Wilmes, Thomas; van den Maagdenberg, Arn; Klugbauer, Norbert

2013-01-01

Voltage-gated CaV2.1 (P/Q-type) Ca2+ channels located at the presynaptic membrane are known to control a multitude of Ca2+-dependent cellular processes such as neurotransmitter release and synaptic plasticity. Our knowledge about their contributions to complex cognitive functions, however, is restricted by the limited adequacy of existing transgenic CaV2.1 mouse models. Global CaV2.1 knock-out mice lacking the α1 subunit Cacna1a gene product exhibit early postnatal lethality which makes them unsuitable to analyse the relevance of CaV2.1 Ca2+ channels for complex behaviour in adult mice. Consequently we established a forebrain specific CaV2.1 knock-out model by crossing mice with a floxed Cacna1a gene with mice expressing Cre-recombinase under the control of the NEX promoter. This novel mouse model enabled us to investigate the contribution of CaV2.1 to complex cognitive functions, particularly learning and memory. Electrophysiological analysis allowed us to test the specificity of our conditional knock-out model and revealed an impaired synaptic transmission at hippocampal glutamatergic synapses. At the behavioural level, the forebrain-specific CaV2.1 knock-out resulted in deficits in spatial learning and reference memory, reduced recognition memory, increased exploratory behaviour and a strong attenuation of circadian rhythmicity. In summary, we present a novel conditional CaV2.1 knock-out model that is most suitable for analysing the in vivo functions of CaV2.1 in the adult murine forebrain. PMID:24205277

Eesti-USA suhetes loevad väärtused / Vello Andres Pettai

Index Scriptorium Estoniae

Pettai, Vello, 1968-

2006-01-01

Ilmunud ka: Järva Teataja 30. nov. lk. 6 lüh. Tartu Ülikooli võrdleva poliitika professor vastab Postimees Online'i lugejate küsimustele, mis puudutavad USA presidendi visiiti Eestisse, viisavabadust USA-ga, USA presidendi võimu, NATO-t, välispoliitikat, riikidevahelisi suhteid, ajakirjandusvabadust, inimõigusi ja demokraatiat

Capture reactions of 40Ca and 48Ca with targets of 197Au and 208Pb

International Nuclear Information System (INIS)

Stokstad, R.; Chan, Y.; Chavez, E.

1988-03-01

The reactions of 40 Ca and 48 Ca with targets of 197 Au and 208 Pb have been measured in the region from below the interaction barrier to about twice the barrier energy. The fission-like fragments were detected in a pair of position-sensitive, multi-wire proportional counters and were identified from measurements of position and time using two-body kinematics. In the region above the barrier the cross sections for capture are less than those given by the touching condition, indicating that an /open quotes/extra push/close quotes/ is required to induce capture. The observations for 40 Ca and 48 Ca show different fissilities for the onset of the extra push and indicate that charge equilibration may be an important factor governing capture reactions. Below the barrier the cross sections show an enhancement relative to the prediction for a one dimensional barrier. The enhancements are larger for 40 Ca than for 48 Ca (for both targets) and this is in qualitative agreement with predictions based on the coupling of the relative motion to low-lying collective states. Both above and below the barrier, we find that the change in the light partner, from 48 Ca to 40 Ca, has a larger effect on the cross sections than the change from 208 Pb to 197 Au, after correction for the change in the Coulomb barrier. 16 refs., 7 figs

A retrospective randomized study to compare the energy delivered using CDE with different techniques and OZil? settings by different surgeons in phacoemulsification

OpenAIRE

Chen, Ming; Sweeney, Henry W; Luke, Becky; Chen, Mindy; Brown, Mathew

2009-01-01

Ming Chen1, Henry W Sweeney2, Becky Luke3, Mindy Chen4, Mathew Brown51University of Hawaii, Honolulu, Hawaii, USA; 2Research Support Services, the Queens Medical Center, Honolulu, Hawaii, USA; 3Surgical Suite, Honolulu, Hawaii, USA; 4University of California, Irvine, CA, USA; 5University of California, San Diego, CA, USAAbstract: Cumulative dissipated energy (CDE) was used with Infiniti® Vision System (Alcon Labs) as an energy delivery guide to compare four different phaco techniques ...

A retrospective randomized study to compare the energy delivered using CDE with different techniques and OZil settings by different surgeons in phacoemulsification

OpenAIRE

Chen, Ming

2009-01-01

Ming Chen1, Henry W Sweeney2, Becky Luke3, Mindy Chen4, Mathew Brown51University of Hawaii, Honolulu, Hawaii, USA; 2Research Support Services, the Queens Medical Center, Honolulu, Hawaii, USA; 3Surgical Suite, Honolulu, Hawaii, USA; 4University of California, Irvine, CA, USA; 5University of California, San Diego, CA, USAAbstract: Cumulative dissipated energy (CDE) was used with Infiniti® Vision System (Alcon Labs) as an energy delivery guide to compare four different phaco techniques ...

Eesti saab tõenäoliselt USA-lt pooletoobise viisavabaduse / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2008-01-01

Algasid läbirääkimised USA-ga viisavabaduse saavutamiseks. USA eksperdid tulevad hindama Eesti riigipiiri pidavust, koostatakse vastastikuse arusaamise memorandum. Tõenäoliselt hakkab Eesti puhul kehtima teistsugune süsteem kui on praegu 27 riigil, kellel on USA-ga viisavabadus ja kellest 15 on EL-i nn vanad riigid. USA sisejulgeoleku ministeeriumi asekantsleri Richard Barthi seisukohti. Vt. samas: Eesti näide võib tekitada vastuolulist reaktsiooni

Formation Mechanism of CaS-Bearing Inclusions and the Rolling Deformation in Al-Killed, Low-Alloy Steel with Ca Treatment

Science.gov (United States)

Xu, Guang; Jiang, Zhouhua; Li, Yang

2016-08-01

The existing form of CaS inclusion in Ca-treated, Al-killed steel during secondary refining process was investigated with scanning electron microscopy and an energy-dispersive spectrometer (EDS). The results of 12 heats industrial tests showed that CaS has two kinds of precipitation forms. One form takes place by the direct reaction of Ca and S, and the other takes place by the reaction of CaO in calcium aluminates with dissolved Al and S in liquid steel. Thermodynamic research for different precipitation modes of CaS under different temperature was carried out. In particular, CaO-Al2O3-CaS isothermal section diagrams and component activities of calcium aluminates were calculated by the thermodynamic software FactSage. By thermodynamic calculation, a precipitation-area diagram of oxide-sulfide duplex inclusion was established by fixing the sulfur content. The quantity of CaS, which was precipitated in a reaction between [Al], [S] and (CaO), can be calculated and predicted based on the precipitation-area diagram of oxide-sulfide duplex inclusion. Electron probe microanalysis and EDS were used for observing rolling deformation of different types of CaS-bearing inclusions during the rolling process. Low modification of calcium aluminates wrapped by CaS has different degrees of harm to steel in the rolling process. A thick CaS layer can prevent some fragile calcium aluminates from being crushed during the rolling process. Some oxide-sulfide duplex inclusion contains little CaS performed better deformation during the rolling process, but when CaS in oxide-sulfide duplex inclusion becomes more, it will cause the whole inclusion to lose plastic yielding ability. The plastic deformation region of CaS-bearing inclusion in a CaO-Al2O3-CaS isothermal section diagram is confirmed.

USA seab tõkkeid odavatele Hiinas toodetud kaupadele / Sirje Rank

Index Scriptorium Estoniae

Rank, Sirje, 1966-

2003-01-01

USA kaubandusdefitsiit Hiinaga kasvab, USA Kongress süüdistab Hiinat ebaausas konkurentsis ja on seadmas Hiina kaupadele impordipiiranguid. Hiina kaalub vastusanktsioone. Diagramm: Kaubandusdefitsiit Hiinaga süveneb

Solidification and Immobilization of Heavy metals in Soil using with nano-metallic Ca/CaO Dispersion Mixture

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Mallampati S. R.

2013-04-01

Full Text Available In the present work, the use of nano-metallic calcium (Ca and calcium oxide (CaO dispersion mixture for the immobilization of heavy metals (As, Cd, Cr and Pb in soil was investigated. With simple grinding, 85-90% of heavy metals immobilization could be achieved, while it could be enhanced to 98-100% by grinding with the addition of nano-metallic Ca/CaO dispersion mixture. By SEM-EDS elemental maps as well as semi-quantitative analysis observed that the amount of As, Cd, Cr and Pb measurable on soil particle surface decreases after nano-metallic Ca/CaO treatment. The leachable heavy metals concentrations were reduced, to the concentration lower than the Japan soil elution standard regulatory threshold, i. e., < 0.01 mg/l for As, Cd and Pb and 0.05mg/l for Cr. Whereas, the effect of soil moisture and pH on heavy metals immobilization was not much influenced. The results suggest that nano-metallic Ca/CaO mixture is suitable to be used for the gentle immobilization of heavy metals contaminated soil at normal moisture conditions.

Innovative partnerships to advance public health training in community-based academic residency programs

Directory of Open Access Journals (Sweden)

Lo JC

2017-10-01

Full Text Available Joan C Lo,1–3 Thomas E Baudendistel,2,3 Abhay Dandekar,3,4 Phuoc V Le,5 Stanton Siu,2,3 Bruce Blumberg6 1Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA; 2Department of Medicine, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA; 3Graduate Medical Education, Kaiser Permanente East Bay, Oakland, CA, USA; 4Department of Pediatrics, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA; 5School of Public Health, University of California Berkeley, Berkeley, CA, USA; 6Graduate Medical Education, Kaiser Permanente Northern California, Oakland, CA, USA Abstract: Collaborative partnerships between community-based academic residency ­training programs and schools of public health, represent an innovative approach to training future physician leaders in population management and public health. In Kaiser Permanente Northern California, development of residency-Masters in Public Health (MPH tracks in the Internal Medicine Residency and the Pediatrics Residency programs, with MPH graduate studies completed at the University of California Berkeley School of Public Health, enables physicians to integrate clinical training with formal education in epidemiology, biostatistics, health policy, and disease prevention. These residency-MPH programs draw on more than 50 years of clinical education, public health training, and health services research – creating an environment that sparks inquiry and added value by developing skills in patient-centered care through the lens of population-based outcomes. Keywords: graduate medical education, public health, master’s degree, internal medicine, pediatrics, residency training

USA toetab Lähis-Ida konfliktides Iisraeli / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

USA kasutas ÜRO Julgeolekunõukogus vetoõigust resolutsiooni suhtes, milles nõuti Iisraelilt Gaza sektoris toimuvate rünnakute kohest lõpetamist, USA ÜRO suursaadiku John Boltoni sõnul oleks dokumendi vastuvõtmine õõnestanud Julgeolekunõukogu usaldusväärsust

Mechanical and thermal-expansion characteristics of Ca10(PO46(OH2-Ca3(PO42 composites

Directory of Open Access Journals (Sweden)

Ruseska G.

2006-01-01

Full Text Available Three types of composites consisting of Ca10(PO46(OH2 and Ca3(PO42 with composition: 75% (wt Ca10(PO46(OH2: 25%(wt Ca3(PO42; 50%(wt Ca10(PO46(OH2: 50%(wtCa3(PO42 and 25 %(wt Ca10(PO46(OH2: 75%(wt Ca3(PO42 were the subject of our investigation. Sintered compacts were in thermal equilibrium, which was proved by the absence of hysteresis effect of the dependence ΔL/L=f(T during heating /cooling in the temperature interval 20-1000-200C. Sintered compacts with the previously mentioned composition possess 26-50% higher values of the E-modulus, G-modulus and K-modulus indicating the presence of a synergism effect. Several proposed model equations for predicting the thermal expansion coefficient in dependence of the thermal and elastic properties of the constitutive phases and their volume fractions, given by: Turner, Kerner, Tummala and Friedberg, Thomas and Taya, were used for making correlations between mechanical and thermal-expansion characteristics of the Ca10(PO46(OH2 - Ca3(PO42 composites. Application of the previously mentioned model equations to all kinds of composites leads to the conclusion that the experimentally obtained results for the thermal expansion coefficient are in an excellent agreement with the theoretical calculated values on account of the volume fraction of each constitutive phase and with all applied model equations, with a coefficient of correlation from 98.16-99.86 %.

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases

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Singh R

2018-03-01

Full Text Available Rajan Singh,1,2 Shehla Pervin,1,2 Se-Jin Lee,3,4 Alan Kuo,5 Victor Grijalva,6 John David,7 Laurent Vergnes,8 Srinivasa T Reddy1,6 1Department of Obstetrics and Gynecology, UCLA School of Medicine, Los Angeles, CA, USA; 2Division of Endocrinology and Metabolism, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA; 3The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA; 4Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, CT, USA; 5Department of Biology, California State University Dominguez Hills, CA, USA; 6Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA, USA; 7Department of Comparative Medicine, Pfizer Inc, San Diego, CA, USA; 8Department of Human Genetics, UCLA School of Medicine, Los Angeles, CA, USA Background: Follistatin (Fst promotes brown adipocyte characteristics in adipose tissues.Methods: Abdominal fat volume (CT scan, glucose clearance (GTT test, and metabolomics analysis (mass spectrometry of adipose tissues from Fst transgenic (Fst-Tg and wild type (WT control mice were analyzed. Oxygen consumption (Seahorse Analyzer and lipidomics (gas chromatography was analyzed in 3T3-L1 cells.Results: Fst-Tg mice show significant decrease in abdominal fat content, increased glucose clearance, improved plasma lipid profiles and significant changes in several conventional metabolites compared to the WT mice. Furthermore, overexpression of Fst in 3T3-L1 cells resulted in up regulation of key brown/beige markers and changes in lipidomics profiles. Conclusion: Fst modulates key factors involved in promoting metabolic syndrome and could be used for therapeutic intervention. Keywords: follistatin, transgenic, adipocyte, fibroblast growth factor 21, AdipoQ

USA väikesed sõbrad Valges Majas / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2018-01-01

President Kersti Kaljulaid külastab Washingtoni ja kohtub USA riigipea Donald Trumpiga. Eesti presidentide eelmistest kohtumistest USA riigipeadega ning Eesti ja Ameerika Ühendriikide kaitsekoostööst

Sustainable viticulture and winery practices in California: What is it, and do customers care?

Directory of Open Access Journals (Sweden)

Gary Zucca

2009-06-01

Full Text Available Gary Zucca1,2, David E Smith3,4, Darryl J Mitry5,61National University, Stockton, CA, USA; 2Owner and Winemaker, Zucca Mountain Vineyards, Vallecito, CA, USA; 3National University, Costa Mesa, CA, USA; 4Copenhagen Business School, Copenhagen, Denmark; 5Graduate School Faculty, Norwich University, Northfield, VT, USA; 6National University, San Diego, CA, USAAbstract: Producers in the wine industry are increasingly competing in the area of product differentiation. The focus of this article is product differentiation via sustainable viticulture and consumer perception. The authors report on their independent research, assess previous findings in the literature, and examine the industry trends. The study concludes with important observations on wine consumer perceptions of sustainable practices in the wine industry and implications for industry practices and product development.Keywords: California, biologique, organic, biodynamic, sustainable

Comparison of Cancer Incidence between China and the USA.

Science.gov (United States)

Wang, Yong-Chuan; Wei, Li-Juan; Liu, Jun-Tian; Li, Shi-Xia; Wang, Qing-Sheng

2012-06-01

The incidence of cancer varies around the globe, especially between less-developed and developed regions. The aim of this study is to explore differences in cancer incidence between China and the USA. Data were obtained from the GLOBOCAN 2008 database. Estimated numbers of new cancer cases in the USA were obtained from the American Cancer Society, while the numbers of cases in China, including those in urban and rural areas, were obtained from 36 cancer registries (2003-2005). Cancer incidence for major sites between China and the USA were analyzed. In China, lung cancer was the predominant type of cancer detected in males; in females, breast cancer was the main type of cancer. Gastrointestinal cancers, such as those of the liver, stomach, and esophagus, were more commonly seen in China than in the USA. A significant difference in the incidence of melanoma of the skin was observed between China and the USA. During comparison of differences in the age-standardized rates by world population (ASRWs) of major cancer sites between the two countries, 4 sites in males (i.e., nasopharynx, esophagus, stomach, and liver) and 6 sites in females (i.e., nasopharynx, esophagus, stomach, liver, gallbladder, and cervix uteri) showed higher cancer incidence rates in China than in the USA. Significant differences in cancer incidence sites were found between the two countries. Cancer may be prevented through public education and awareness. Programs to promote cancer prevention in China, especially those of the lung, breast, and gastrointestinal region, must also be implemented.

Ravimitööstuse tuleviku kujundavad USA pensionärid / Mikk Salu

Index Scriptorium Estoniae

Salu, Mikk, 1975-

2008-01-01

Kolmveerand maailma ravimitööstuse kasumist tuleb USA-st. Ravimitootjate tähelepanu pälvivad need haigused, mis USA-s enim levinud - kõige rohkem on raha eraldatud ülekaalulisusega seotud haiguste, samuti vähi raviks

Oletus : USA luurevanglad on Poolas ja Rumeenias / Krister Paris

Index Scriptorium Estoniae

Paris, Krister, 1977-

2005-01-01

USA ajalehe Washington Post andmeil hoiab USA terrorismis kahtlustavaid Ida-Euroopa riikides. Poola ajalehe allikate väitel on üks neist riikidest Poola. Poola, Rumeenia, Bulgaaria tõrjuvad kahtlustusi, Tšehhi väitel on ameeriklaste palvele vange majutada ära öeldud

Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3.

Directory of Open Access Journals (Sweden)

Roman A Sandler

2017-07-01

Full Text Available Much of the research on cannabinoids (CBs has focused on their effects at the molecular and synaptic level. However, the effects of CBs on the dynamics of neural circuits remains poorly understood. This study aims to disentangle the effects of CBs on the functional dynamics of the hippocampal Schaffer collateral synapse by using data-driven nonparametric modeling. Multi-unit activity was recorded from rats doing an working memory task in control sessions and under the influence of exogenously administered tetrahydrocannabinol (THC, the primary CB found in marijuana. It was found that THC left firing rate unaltered and only slightly reduced theta oscillations. Multivariate autoregressive models, estimated from spontaneous spiking activity, were then used to describe the dynamical transformation from CA3 to CA1. They revealed that THC served to functionally isolate CA1 from CA3 by reducing feedforward excitation and theta information flow. The functional isolation was compensated by increased feedback excitation within CA1, thus leading to unaltered firing rates. Finally, both of these effects were shown to be correlated with memory impairments in the working memory task. By elucidating the circuit mechanisms of CBs, these results help close the gap in knowledge between the cellular and behavioral effects of CBs.

USA moos määrib Eesti naabritest mõjukamaks / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2007-01-01

Sel sügisel on toimunud mitu Eesti ja USA poliitikute kohtumist. Peaminister Andrus Ansipi ja kaitseminister Jaak Aaviksoo USA-visiitide korraldamisega kursis olevad ametnikud ei nõustu, et kohtumiste taga oleks olnud USA lobitöö Iraagi missiooni pikendamiseks

IVF global histories, USA: between Rock and a marketplace

Directory of Open Access Journals (Sweden)

Charis Thompson

2016-06-01

Full Text Available The USA has played, and continues to play, a distinctive and significant part in the history of IVF and assisted reproductive technology worldwide. American IVF emerged in the scientific context of contraceptive and fertility research, in the social context of a wealthy nation without universal healthcare, and in the political context of the abortion debate and its impact on federal versus state funding and regulation. IVF had its first clinical success in the USA in 1981. Since then, IVF in the USA has become known for procedures involving third, fourth and fifth parties as gamete donors and surrogates. The USA has also been one of the pioneers in domestic and transnational deployment of IVF for lesbian, gay, bisexual, transgender (LGBT parenthood, and a pioneer of the social egg-freezing revolution. US IVF has been marked by professional and patient advocacy for such things as the honest reporting of success rates, recognition of the risks of postponed childbearing, and the need for insurance coverage. Certain landmark legal custody disputes over IVF embryos and offspring, as well as media attention to gendered, racialized, and class-based access to and pricing of assisted reproductive technology, have also driven the development of IVF in the USA.

A dynamic model of interactions of Ca2+, calmodulin, and catalytic subunits of Ca2+/calmodulin-dependent protein kinase II.

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Shirley Pepke

2010-02-01

Full Text Available During the acquisition of memories, influx of Ca2+ into the postsynaptic spine through the pores of activated N-methyl-D-aspartate-type glutamate receptors triggers processes that change the strength of excitatory synapses. The pattern of Ca2+influx during the first few seconds of activity is interpreted within the Ca2+-dependent signaling network such that synaptic strength is eventually either potentiated or depressed. Many of the critical signaling enzymes that control synaptic plasticity,including Ca2+/calmodulin-dependent protein kinase II (CaMKII, are regulated by calmodulin, a small protein that can bindup to 4 Ca2+ ions. As a first step toward clarifying how the Ca2+-signaling network decides between potentiation or depression, we have created a kinetic model of the interactions of Ca2+, calmodulin, and CaMKII that represents our best understanding of the dynamics of these interactions under conditions that resemble those in a postsynaptic spine. We constrained parameters of the model from data in the literature, or from our own measurements, and then predicted time courses of activation and autophosphorylation of CaMKII under a variety of conditions. Simulations showed that species of calmodulin with fewer than four bound Ca2+ play a significant role in activation of CaMKII in the physiological regime,supporting the notion that processing of Ca2+ signals in a spine involves competition among target enzymes for binding to unsaturated species of CaM in an environment in which the concentration of Ca2+ is fluctuating rapidly. Indeed, we showed that dependence of activation on the frequency of Ca2+ transients arises from the kinetics of interaction of fluctuating Ca2+with calmodulin/CaMKII complexes. We used parameter sensitivity analysis to identify which parameters will be most beneficial to measure more carefully to improve the accuracy of predictions. This model provides a quantitative base from which to build more complex dynamic

USA saadik : Lihula sammas oli solvav / Aldona Zofia Wos ; interv. Erkki Bahovski

Index Scriptorium Estoniae

Wos, Aldona Zofia

2005-01-01

USA suursaadik Eestis vastab küsimustele, mis puudutavad Eesti-USA suhteid, eestlaste võimalust saada kunagi sõita USA-sse ilma viisata, Lihula mälestusmärgi mahavõtmist, valimisi ja jätkuvat vägivalda Iraagis, HI-viiruse levikut

Significance of the tumor markers CA 125 and CA 15-3 in postoperative diagnosis of ovarian and breast cancer

International Nuclear Information System (INIS)

Johannsen, B.; Bartel, U.; Elling, D.

1989-01-01

In 271 patients with ovarian carcinoma, benign ovarian tumors, breast cancer, and two control groups, serum levels of CA 125, CA 15-3, CEA and, partly, CA 19-9 were determined immunoradiometrically. According to the results of the determination of CA 125 in the follow-up of ovarian carcinoma, CA 125 represents a useful marker for early detection of recurrences, especially in cases of diffuse carcinoma dissemination. In incomplete tumor debulking, postoperative CA 125 serum levels did not prove to be helpful except that a positive level renders invasive diagnostic investigation no longer necessary. Postoperative follow-up in breast cancer early reveals distant metastases, with very high levels in patients with bone metastases. By simultaneous measurement of CA 15-3 and CEA the sensitivity could be increased from 86% (CA 15-3 only) to 93%. (author)

Multiple Ca2+ sensors in secretion

DEFF Research Database (Denmark)

Walter, Alexander M; Groffen, Alexander J; Sørensen, Jakob Balslev

2011-01-01

Regulated neurotransmitter secretion depends on Ca(2+) sensors, C2 domain proteins that associate with phospholipids and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) complexes to trigger release upon Ca(2+) binding. Ca(2+) sensors are thought to prevent spontaneous...

Ion microprobe assessment of the heterogeneity of Mg/Ca, Sr/Ca and Mn/Ca ratios in Pecten maximus and Mytilus edulis (bivalvia shell calcite precipitated at constant temperature

Directory of Open Access Journals (Sweden)

P. S. Freitas

2009-07-01

Full Text Available Small-scale heterogeneity of biogenic carbonate elemental composition can be a significant source of error in the accurate use of element/Ca ratios as geochemical proxies. In this study ion microprobe (SIMS profiles showed significant small-scale variability of Mg/Ca, Sr/Ca and Mn/Ca ratios in new shell calcite of the marine bivalves Pecten maximus and Mytilus edulis that was precipitated during a constant-temperature culturing experiment. Elevated Mg/Ca, Sr/Ca and Mn/Ca ratios were found to be associated with the deposition of elaborate shell features, i.e. a shell surface stria in P. maximus and surface shell disturbance marks in both species, the latter a common occurrence in bivalve shells. In both species the observed small-scale elemental heterogeneity most likely was not controlled by variable transport of ions to the extra-pallial fluid, but by factors such as the influence of shell organic content and/or crystal size and orientation, the latter reflecting conditions at the shell crystal-solution interface. In the mid and innermost regions of the P. maximus shell the lack of significant small-scale variation of Mg/Ca ratios, which is consistent with growth at constant temperature, suggest a potential application as a palaeotemperature proxy. Cross-growth band element/Ca ratio profiles in the interior of bivalve shells may provide more promising palaeo-environmental tools than sampling from the outer region of bivalve shells.

Clinical value of multi-tumor markers detection with (CEA, CA19-9, CA72-4) for diagnosis of gastric malignancy

International Nuclear Information System (INIS)

Liu Yun; Li Jiangang

2007-01-01

Objective: To assess the clinical value of multi-tumor markers detection with (CEA, CA19-9, CA72-4) for diagnosis of gastric malignancy. Methods: Serum CEA, CA19-9, CA72-4 contents were measured with IRMA in 228 patients with gastric malignancies, 152 patients with benign gastric disorders and 200 controls. Results: The positive rates of single marker detection were all above 70% and that of CA72-4 was the highest (84.21%), next was CA19-9 (75.43%). Three tumor markers were all negative in only 4 cases (false negative rate was 1.75% ). So combined detection of 3 tumor markers could improve the positive rate to 98.25%. With combined determination of two markers, double positive rate for different sets of combinations was: 61.84% for CA72-4 + CA19-9, 51.31% for CA72-4 + CEA and 48.24% for CEA + CA19-9. Conclusion: It was suggested that for screening, CA72-4 was the first choice in single marker detections, and CA72-4 + CA19-9 was the first choice for combined detections of two markers. For follow-up, a combination of 2 markers with highest positive rate for the specific histopathologic type (i. e. carcinoma, leiomyosarcoma or lymphosarcoma) should be used throughout the study. (authors)

Alar Laneman siirdub USA-sse kaitseatašeeks / Holger Roonemaa

Index Scriptorium Estoniae

Roonemaa, Holger

2007-01-01

Brigaadikindral Alar Lanemanist võib saada Eesti kaitseatašee USA-s. Endise kaitseministri Jürgen Ligi sõnul oli A. Laneman osaline mitmetes juhtimisvigades ning neist ühe puhul kestab senini kriminaalasi

CaMKII in sinoatrial node physiology and dysfunction

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Yuejin eWu

2014-03-01

Full Text Available The calcium and calmodulin dependent protein kinase II (CaMKII is present in sinoatrial node (SAN pacemaker cells and is required for physiological fight or flight SAN beating rate responses. Inhibition of CaMKII in SAN does not affect baseline heart rate, but reduces heart rate increases in response to physiological stress. CaMKII senses intracellular calcium (Ca2+ changes, oxidation status and hyperglycemia to phosphorylate substrates that regulate Ca2+-sensitive proteins, such as L-type Ca2+ channels, phospholamban (PLN, and cardiac ryanodine receptors (RyR2. All of these substrates are involved in the SAN pacemaking mechanism. Excessive CaMKII activity, as occurs under pathological conditions such as heart failure, ischemia and diabetes, can promote intracellular Ca2+ overload and reactive oxygen species (ROS production. Oxidation of CaMKII (ox-CaMKII locks CaMKII into a constitutively active configuration that contributes to SAN cell apoptosis and fibrosis. This ox-CaMKII-mediated loss of functional SAN cells contributes to sinoatrial node dysfunction (SND and sudden death. Thus, CaMKII has emerged as a central regulator of physiological SAN responses and a key determinant of SND.

EXISTENCE OF POSITIVE SOLUTIONS FOR AN ELASTIC CURVED BEAM EQUATION

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Béla Kovacs

2017-06-01

Full Text Available This paper investigates the existence of positive solutions for a sixth-order differential equations. By using the Leggett-Williams fixed point theorem we give some new existence results.

CaMKII in the Cardiovascular System: Sensing Redox States

Science.gov (United States)

Erickson, Jeffrey R.; He, B. Julie; Grumbach, Isabella M.; Anderson, Mark E

2013-01-01

The multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) is now recognized to play a central role in pathological events in the cardiovascular system. CaMKII has diverse downstream targets that promote vascular disease, heart failure and arrhythmias, so improved understanding of CaMKII signaling has the potential to lead to new therapies for cardiovascular disease. CaMKII is a multimeric serine-threonine kinase that is initially activated by binding calcified calmodulin (Ca2+/CaM). Under conditions of sustained exposure to elevated Ca2+/CaM CaMKII transitions into a Ca2+/CaM-autonomous enzyme by two distinct but parallel processes. Autophosphorylation of threonine 287 in the CaMKII regulatory domain ‘traps’ CaMKII into an open configuration even after Ca2+/CaM unbinding. More recently, our group identified a pair of methionines (281/282) in the CaMKII regulatory domain that undergo a partially reversible oxidation which, like autophosphorylation, prevents CaMKII from inactivating after Ca2+/CaM unbinding. Here we review roles of CaMKII in cardiovascular disease with an eye to understanding how CaMKII may act as a transduction signal to connect pro-oxidant conditions into specific downstream pathological effects that are relevant to rare and common forms of cardiovascular disease. PMID:21742790

Nuclear electricity in the U.S.A. - A status report

Energy Technology Data Exchange (ETDEWEB)

Loewenstein, W B [American Nuclear Society, Hinsdale, IL (United States)

1990-06-01

The status of nuclear electricity programs in the USA is reviewed. About 20% of the electricity in the USA comes from nuclear generating stations. The potential impact of greenhouse concerns is prominent in plans for the future. Advanced reactor programs for water, liquid metal and gas cooled systems is reviewed. Safety and plant economics feature prominently in future considerations. The increasing average availability of nuclear stations in the USA provides some insights on lessons to be learned for the future. (author)

Nuclear electricity in the U.S.A. - A status report

International Nuclear Information System (INIS)

Loewenstein, W.B.

1990-01-01

The status of nuclear electricity programs in the USA is reviewed. About 20% of the electricity in the USA comes from nuclear generating stations. The potential impact of greenhouse concerns is prominent in plans for the future. Advanced reactor programs for water, liquid metal and gas cooled systems is reviewed. Safety and plant economics feature prominently in future considerations. The increasing average availability of nuclear stations in the USA provides some insights on lessons to be learned for the future. (author)

Determination of Mo- and Ca-isotope ratios in Ca100MoO4 crystal for AMoRE-I experiment

Science.gov (United States)

Karki, S.; Aryal, P.; Kim, H. J.; Kim, Y. D.; Park, H. K.

2018-01-01

The first phase of the AMoRE (Advanced Mo-based Rare process Experiment) is to search for neutrinoless double-beta decay of 100Mo with calcium molybdate (Ca100MoO4) crystals enriched in 100Mo and depleted in 48Ca using a cryogenic technique at Yangyang underground laboratory in Korea. It is important to know 100Mo- and 48Ca-isotope ratios in Ca100MoO4 crystal to estimate half-life of 100Mo decays and to 2 νββ background from 48Ca. We employed the ICP-MS (Inductive Coupled Plasma Mass Spectrometer) to measure 100Mo- and 48Ca-isotope ratios in Ca100MoO4 crystal. The measured results for 100Mo- and 48Ca-isotope ratios in the crystal are (94 . 6 ± 2 . 8) % and (0 . 00211 ± 0 . 00006) %, respectively, where errors are included both statistical and systematic uncertainties.

USA-USSR protocol

CERN Multimedia

1970-01-01

On 30 November the USA Atomic Energy Commission and the USSR State Committee for the Utilization of Atomic Energy signed, in Washington, a protocol 'on carrying out of joint projects in the field of high energy physics at the accelerators of the National Accelerator Laboratory (Batavia) and the Institute for High Energy Physics (Serpukhov)'. The protocol will be in force for five years and can be extended by mutual agreement.

The destiny of Ca(2+) released by mitochondria.

Science.gov (United States)

Takeuchi, Ayako; Kim, Bongju; Matsuoka, Satoshi

2015-01-01

Mitochondrial Ca(2+) is known to regulate diverse cellular functions, for example energy production and cell death, by modulating mitochondrial dehydrogenases, inducing production of reactive oxygen species, and opening mitochondrial permeability transition pores. In addition to the action of Ca(2+) within mitochondria, Ca(2+) released from mitochondria is also important in a variety of cellular functions. In the last 5 years, the molecules responsible for mitochondrial Ca(2+) dynamics have been identified: a mitochondrial Ca(2+) uniporter (MCU), a mitochondrial Na(+)-Ca(2+) exchanger (NCLX), and a candidate for a mitochondrial H(+)-Ca(2+) exchanger (Letm1). In this review, we focus on the mitochondrial Ca(2+) release system, and discuss its physiological and pathophysiological significance. Accumulating evidence suggests that the mitochondrial Ca(2+) release system is not only crucial in maintaining mitochondrial Ca(2+) homeostasis but also participates in the Ca(2+) crosstalk between mitochondria and the plasma membrane and between mitochondria and the endoplasmic/sarcoplasmic reticulum.

Methicillin-resistant Staphylococcus aureus in Rio de Janeiro hospitals: dissemination of the USA400/ST1 and USA800/ST5 SCCmec type IV and USA100/ST5 SCCmec type II lineages in a public institution and polyclonal presence in a private one.

Science.gov (United States)

Caboclo, Roberta Mello Ferreira; Cavalcante, Fernanda Sampaio; Iorio, Natalia Lopes Pontes; Schuenck, Ricardo Pinto; Olendzki, André Nogueira; Felix, Maria José; Chamon, Raiane Cardoso; dos Santos, Kátia Regina Netto

2013-03-01

Methicillin-resistant Staphylococcus aureus (MRSA) infections have changed since certain non-multiresistant MRSA lineages have emerged in hospitals. In this study, 99 MRSA isolates, 77 from a public and 22 from a private hospital, were characterized. Isolates were tested for antimicrobial susceptibility, whereas staphylococcal chromosomal cassette mec (SCCmec) typing and Panton-Valentine leukocidin genes were assessed by polymerase chain reaction. Pulsed-field gel electrophoresis and multilocus sequence typing analyses were carried out to determine the MRSA lineages. High rates of resistance were found to erythromycin (96%), ciprofloxacin (93%), and clindamycin (90%). The SCCmec types found were as follows: type II (14.2%), III (62.6%), and IV (23.2%). Approximately 85% of type III isolates was related to the Brazilian epidemic clone in both hospitals. For type IV isolates, 94.4% were related to both USA400/ sequence type (ST) 1 and USA800/ST5 lineages in the public hospital, whereas the USA400/ST1, USA800/ST5, USA1100/ST30, and EMRSA (Epidemic MRSA)-15/ST22 lineages were detected in the private hospital. Among the SCCmec II isolates, approximately 85% were related to the USA100/ST5 lineage. Three MRSA isolates were positive to Panton-Valentine leukocidin genes. The study showed that there was an emergence of USA400/ST1, USA800/ST5 SCCmec IV, and USA100/ST5 SCCmec II MRSA lineages in both hospitals. There was a dissemination of them in the public hospital and a polyclonal presence of the MRSA isolates in the private hospital. The spread of these lineages can be facilitated by the characteristics of the health institution. Copyright © 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

Hvad SKER der med drikkevandet i USA?

DEFF Research Database (Denmark)

Ramsay, Loren Mark

2017-01-01

Forskellige lande har forskellige traditioner indenfor drikkevandsbehandling. Denne beretning fra ”Water Quality Technology Conference” i USA er set med en særlig vinkel, da forfatteren er amerikansk statsborger, men har arbejdet i den danske vandbranche i mere end 25 år.......Forskellige lande har forskellige traditioner indenfor drikkevandsbehandling. Denne beretning fra ”Water Quality Technology Conference” i USA er set med en særlig vinkel, da forfatteren er amerikansk statsborger, men har arbejdet i den danske vandbranche i mere end 25 år....

I. The properties of hot Ca-like fragments from the 40Ca+40Ca reaction at 35 AMeV

International Nuclear Information System (INIS)

Planeta, R.; Gawlikowicz, W.; Wieloch, A.

2001-01-01

The creation of hot Ca-like fragments was investigated in the 40 Ca + 40 Ca reaction at 35 AMeV. Using the AMPHORA 4π detector system, the primary projectile-like fragment was reconstructed and its properties were determined. Both primary and secondary distributions are compared with the predictions of a Monte Carlo code describing a heavy-ion collision as a two-step process. Some of the nucleons which are identified as participants in the first step are transferred in the second step to these final states, which correspond on the average to the maximum value of entropy (thermodynamic probability). The model allows for competition between mean-field effects and nucleon-nucleon interactions in the overlap zone of the interacting nuclei. The analysis presented here suggests a thermalized source picture of the decay of the projectile-like fragment. The validity of the reconstruction procedure for projectile-like fragments is discussed. (orig.)

Reassigning the CaH+ 11Σ → 21Σ vibronic transition with CaD+

Science.gov (United States)

Condoluci, J.; Janardan, S.; Calvin, A. T.; Rugango, R.; Shu, G.; Sherrill, C. D.; Brown, K. R.

2017-12-01

We observe vibronic transitions in CaD+ between the 11Σ and 21Σ electronic states by resonance enhanced multiphoton photodissociation spectroscopy in a Coulomb crystal. The vibronic transitions are compared with previous measurements on CaH+. The result is a revised assignment of the CaH+ vibronic levels and a disagreement with multi-state-complete-active-space second-order perturbation theory theoretical calculations by approximately 700 cm-1. Updated high-level coupled-cluster calculations that include core-valence correlations reduce the disagreement between theory and experiment to 300 cm-1.

Clinical Significance and Prognostic Value of CA72-4 Compared with CEA and CA19-9 in Patients with Gastric Cancer

Directory of Open Access Journals (Sweden)

M. Ychou

2000-01-01

Full Text Available Carcinoembryonic antigen (CEA and CA 19-9 are both widely used in the follow up of patients with gastrointestinal cancer. More recently another tumor marker, named CA 72-4 has been identified and characterized using two different monoclonal antibodies B72.3 and CC49. Several reports evaluated CA 72-4 as a serum tumor marker for gastric cancer and compared its clinical utility with that of CEA or CA 19-9; few reports concerned its prognostic value. In the present study, CA 72-4 is evaluated and compared with CEA and CA 19-9 in various populations of patients with gastric cancer and benign disease; for 52 patients with gastric adenocarcinoma and 57 patients without neoplastic disease CEA, CA 19-9 and CA 72-4 were evaluated before treatment. Sensitivity of the tumor markers CA 72-4, CA 19-9 and CEA at the recommended cut-off level in all 52 patients were 58%, 50% the sensitivity increased to 75%. of these markers, for non metastatic patients, multivariate analyses indicated that none of the markers were significant, when adjusted for gender and age (which were indicators of poor prognosis; patients with abnormal values of CA72-4 tended to have shorter survival than patients with normal values (p < 0.07. In the metastatic population, only high values of CA19-9 (p < 0.02 and gender (women (p < 0.03 were indicators of poor prognosis in univariate analysis; multivariate analysis revealed that both CA72-4 (p = 0.034 and CA19-9 p = 0.009, adjusted for gender were independent prognostic factors. However, CA72-4 lost significance (p = 0.41 when adjusted for CA19-9 and gender, indicating that CA19-9 provides more prognostic information than CA72-4.

Semantic web data warehousing for caGrid.

Science.gov (United States)

McCusker, James P; Phillips, Joshua A; González Beltrán, Alejandra; Finkelstein, Anthony; Krauthammer, Michael

2009-10-01

The National Cancer Institute (NCI) is developing caGrid as a means for sharing cancer-related data and services. As more data sets become available on caGrid, we need effective ways of accessing and integrating this information. Although the data models exposed on caGrid are semantically well annotated, it is currently up to the caGrid client to infer relationships between the different models and their classes. In this paper, we present a Semantic Web-based data warehouse (Corvus) for creating relationships among caGrid models. This is accomplished through the transformation of semantically-annotated caBIG Unified Modeling Language (UML) information models into Web Ontology Language (OWL) ontologies that preserve those semantics. We demonstrate the validity of the approach by Semantic Extraction, Transformation and Loading (SETL) of data from two caGrid data sources, caTissue and caArray, as well as alignment and query of those sources in Corvus. We argue that semantic integration is necessary for integration of data from distributed web services and that Corvus is a useful way of accomplishing this. Our approach is generalizable and of broad utility to researchers facing similar integration challenges.

CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype.

Science.gov (United States)

Busquet, Perrine; Nguyen, Ngoc Khoi; Schmid, Eduard; Tanimoto, Naoyuki; Seeliger, Mathias W; Ben-Yosef, Tamar; Mizuno, Fengxia; Akopian, Abram; Striessnig, Jörg; Singewald, Nicolas

2010-05-01

Mounting evidence suggests that voltage-gated L-type Ca2+ channels can modulate affective behaviour. We therefore explored the role of CaV1.3 L-type Ca2+ channels in depression- and anxiety-like behaviours using CaV1.3-deficient mice (CaV1.3-/-). We showed that CaV1.3-/- mice displayed less immobility in the forced swim test as well as in the tail suspension test, indicating an antidepressant-like phenotype. Locomotor activity in the home cage or a novel open-field test was not influenced. In the elevated plus maze (EPM), CaV1.3-/- mice entered the open arms more frequently and spent more time there indicating an anxiolytic-like phenotype which was, however, not supported in the stress-induced hyperthermia test. By performing parallel experiments in Claudin 14 knockout mice (Cldn14-/-), which like CaV1.3-/- mice are congenitally deaf, an influence of deafness on the antidepressant-like phenotype could be ruled out. On the other hand, a similar EPM behaviour indicative of an anxiolytic phenotype was also found in the Cldn14-/- animals. Using electroretinography and visual behavioural tasks we demonstrated that at least in mice, CaV1.3 channels do not significantly contribute to visual function. However, marked morphological changes were revealed in synaptic ribbons in the outer plexiform layer of CaV1.3-/- retinas by immunohistochemistry suggesting a possible role of this channel type in structural plasticity at the ribbon synapse. Taken together, our findings indicate that CaV1.3 L-type Ca2+ channels modulate depression-like behaviour but are not essential for visual function. The findings raise the possibility that selective modulation of CaV1.3 channels could be a promising new therapeutic concept for the treatment of mood disorders.

USA väed võivad hakata Iraagist lahkuma / Kaarel Kaas

Index Scriptorium Estoniae

Kaas, Kaarel, 1978-

2005-01-01

USA on Iraagis toimuvate valimiste eel saatnud sinna lisavägesid. Vägivalla tõttu võivad mõnes Iraagi piirkonnas valimised ära jääda. USA välisministri Colin Powelli sõnul võivad USA sõdurid juba sel aastal hakata järk-järgult Iraagist lahkuma, kui Iraagil endal õnnestub saada suurem roll turvalisuse tagamisel. Lisa: Kaotused Iraagis

Neomysin inhibits Ca2+-stimulated phosphatidylinositol hydrolysis and protects cultured rat cardiomyocytes from Ca2+-dependent cell injury

International Nuclear Information System (INIS)

Babson, J.R.; Dougherty, J.M.

1991-01-01

Exposure of cultured rat cardiomyocytes to ionomycin and extracellular Ca 2+ leads to a rapid, sustained increase in intracellular free Ca 2+ as monitored by Ca 2+ -dependent phosphorylase a activation and to a subsequent loss of cardiomyocyte viability as determined by lactate dehydrogenase (LDH) leakage. The intracellular free Ca 2+ increase coincided with a rapid hydrolysis of phosphatidylinositol that preceded cell death. Phosphatidylinositol hydrolysis was monitored by the release of radiolabeled phosphoinositides from cardiomyocytes prelabeled with [2- 3 H]-myo-inositol. Neomycin, a known inhibitor of phospholipase C, inhibited the phosphatidylinositol hydrolysis and markedly reduced the extent of cell injury. Inhibitors of other Ca 2+ -activated processes, including intracellular proteases and phospholipase A 2 , had no effect on ionomycin-mediated cell injury. These data suggest that ionomycin-induced Ca 2+ -dependent cell injury in cultured cardiomyocytes may be due in part to the stimulation of phosphatidylinositol hydrolysis, presumably catalyzed by a Ca 2+ -dependent phospholipase C

Assessment of diagnostic value of various tumors markers (CEA, CA199, CA50) for colorectal neoplasm with logistic regression and ROC curve

International Nuclear Information System (INIS)

Gu Ping; Huang Gang; Han Yuan

2007-01-01

Objective: To assess the diagnostic value of CEA, CA199 and CA50 for colorectal neoplasm by logistic regression and ROC curve. Methods: Serum CEA (with CLIA), CA199 (with ECLIA) and CA50 (with IRMA) levels were measured in 75 patients with colorectal cancer, 35 patients with benign colorectal disorders and 49 controls. The area under the ROC curve (AUC)s of CEA, CA199, CA50 from logistic regression results were compared. Results: In the cancer-benign disorder group, the AUC of CA50 was larger than the AUC of CA199. AUC of combined CEA, CA50 was largest: not only larger than any AUC of CEA, CA50, CA199 alone but also larger than the AUC of the combined three markers (0.875 vs 0.604). In cancer-control group, the AUC of combination of CEA, CA199 and CA50 was larger than any AUC of CEA, CA199 or CA50 alone. Both in the cancer-benign disorder group or cancer-control group, the AUC of CEA was larger than the AUC of CA199 or CA50. Conclusion: CEA is of definite value in the diagnosis of colorectal cancer. For differential diagnosis, the combination of CEA and CA50 can give more information, while the combination of three tumor markers is less helpful. As an advanced statistical method, logistic regression can improve the diagnostic sensitivity and specificity. (authors)

Copper bioavailability and toxicity to Mytilus galloprovincialis in Shelter Island Yacht Basin, San Diego, CA.

Science.gov (United States)

Bosse, Casey; Rosen, Gunther; Colvin, Marienne; Earley, Patrick; Santore, Robert; Rivera-Duarte, Ignacio

2014-08-15

The bioavailability and toxicity of copper (Cu) in Shelter Island Yacht Basin (SIYB), San Diego, CA, USA, was assessed with simultaneous toxicological, chemical, and modeling approaches. Toxicological measurements included laboratory toxicity testing with Mytilus galloprovincialis (Mediterranean mussel) embryos added to both site water (ambient) and site water spiked with multiple Cu concentrations. Chemical assessment of ambient samples included total and dissolved Cu concentrations, and Cu complexation capacity measurements. Modeling was based on chemical speciation and predictions of bioavailability and toxicity using a marine Biotic Ligand Model (BLM). Cumulatively, these methods assessed the natural buffering capacity of Cu in SIYB during singular wet and dry season sampling events. Overall, the three approaches suggested negligible bioavailability, and isolated observed or predicted toxicity, despite an observed gradient of increasing Cu concentration, both horizontally and vertically within the water body, exceeding current water quality criteria for saltwater. Published by Elsevier Ltd.

USA üritab leida Teherani agente Iraagist / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2007-01-01

USA süüdistab Iraani, et see abistab Iraagis mahdiste, mida juhib Muqtada al-Sadri. Autori sõnul on Iraani eliitüksuse Qudsi korpuse koostööd al-Sadriga aga sama vähe tõestatud kui omal ajal USA väidet Saddam Husseini ja al-Qaida vahel

FY2015 Analysis of the Teamwork USA Program. Memorandum

Science.gov (United States)

Howard, Mark

2015-01-01

The Department of Research and Evaluation (DRE) has completed an analysis of the performance of students who participated in the Teamwork USA Program, administered in FY2014 at three District schools. Teamwork USA hopes to improve student achievement at select Title I elementary schools via its Instrumental Music Program grant. This memorandum to…

CaMKII determines mitochondrial stress responses in heart

Science.gov (United States)

Joiner, Mei-ling A.; Koval, Olha M.; Jingdong, Li; He, B. Julie; Allamargot, Chantal; Gao, Zhan; Luczak, Elizabeth D.; Hall, Duane D.; Fink, Brian D.; Chen, Biyi; Yang, Jinying; Moore, Steven A.; Scholz, Thomas D.; Strack, Stefan; Mohler, Peter J.; Sivitz, William I.; Song, Long-Sheng; Anderson, Mark E.

2012-01-01

Myocardial cell death is initiated by excessive mitochondrial Ca2+ entry, causing Ca2+ overload, mitochondrial permeability transition pore (mPTP) opening and dissipation of the mitochondrial inner membrane potential (ΔΨm)1,2. However, the signaling pathways that control mitochondrial Ca2+ entry through the inner membrane mitochondrial Ca2+ uniporter (MCU)3–5 are not known. The multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) is activated in ischemia reperfusion (I/R), myocardial infarction (MI) and neurohumoral injury, common causes of myocardial death and heart failure, suggesting CaMKII could couple disease stress to mitochondrial injury. Here we show that CaMKII promotes mPTP opening and myocardial death by increasing MCU current (IMCU). Mitochondrial-targeted CaMKII inhibitory protein or cyclosporin A (CsA), an mPTP antagonist with clinical efficacy in I/R injury6, equivalently prevent mPTP opening, ΔΨm deterioration and diminish mitochondrial disruption and programmed cell death in response to I/R injury. Mice with myocardial and mitochondrial-targeted CaMKII inhibition are resistant to I/R injury, MI and neurohumoral injury, suggesting pathological actions of CaMKII are substantially mediated by increasing IMCU. Our findings identify CaMKII activity as a central mechanism for mitochondrial Ca2+ entry and suggest mitochondrial-targeted CaMKII inhibition could prevent or reduce myocardial death and heart failure dysfunction in response to common experimental forms of pathophysiological stress. PMID:23051746

77 FR 30027 - Manufacturer of Controlled Substances; Notice of Registration; Siegfried (USA)

Science.gov (United States)

2012-05-21

...; Notice of Registration; Siegfried (USA) By Notice dated January 6, 2012, and published in the Federal Register on January 17, 2012, 77 FR 2323, Siegfried (USA), 33 Industrial Park Road, Pennsville, New Jersey... U.S.C. 823(a) and determined that the registration of Siegfried (USA), to manufacture the listed...

Tumour associated antigen CA-50, CA-242 immunoradiometric assay (IRMA) in genitourinary malignancy and gastrointestinal carcinoma early diagnosis

International Nuclear Information System (INIS)

Chen Zhizhou.

1992-04-01

Tumour markers CA-50 and CA-242 were measured by immunometric assay (IRMA) to investigate their usefulness in the diagnosis of cancer of the pancreas, biliary tract, liver, breast, lung, gastrointestinal and genitourinary systems. The cutoff points, derived from studies on normal subjects and those with proven benign disease, were 20 u/ml and 12 u/ml for CA-50 and CA-242 respectively. Both markers were found to be generally useful with significant differences between malignant and non malignant disease. The highest positive rates, were found in cancers of the pancreas and gall bladder. The overall rate of false positives was low. It is concluded that measurements of CA-50 and CA-242 are useful in the detection of malignancy, particularly of the pancreas and biliary tract. 2 figs, 2 tabs

Crystallization and Colloidal Stabilization of Ca(OH)2 in the Presence of Nopal Juice (Opuntia ficus indica): Implications in Architectural Heritage Conservation.

Science.gov (United States)

Rodriguez-Navarro, Carlos; Ruiz-Agudo, Encarnacion; Burgos-Cara, Alejandro; Elert, Kerstin; Hansen, Eric F

2017-10-17

Hydrated lime (Ca(OH) 2 ) is a vernacular art and building material produced following slaking of CaO in water. If excess water is used, a slurry, called lime putty, forms, which has been the preferred craftsman selection for formulating lime mortars since Roman times. A variety of natural additives were traditionally added to the lime putty to improve its quality. The mucilaginous juice extracted from nopal cladodes has been and still is used as additive incorporated in the slaking water for formulation of lime mortars and plasters, both in ancient Mesoamerica and in the USA Southwest. Little is known on the ultimate effects of this additive on the crystallization and microstructure of hydrated lime. Here, we show that significant changes in habit and size of portlandite crystals occur following slaking in the presence of nopal juice as well as compositionally similar citrus pectin. Both additives contain polysaccharides made up of galacturonic acid and neutral sugar residues. The carboxyl (and hydroxyl) functional groups present in these residues and in their alkaline degradation byproducts, which are deprotonated at the high pH (12.4) produced during lime slaking, strongly interact with newly formed Ca(OH) 2 crystals acting in two ways: (a) as nucleation inhibitors, promoting the formation of nanosized crystals, and (b) as habit modifiers, favoring the development of planar habit following their adsorption onto positively charged (0001) Ca(OH) 2 faces. Adsorption of polysaccharides on Ca(OH) 2 crystals prevents the development of large particles, resulting in a very reactive, nanosized portlandite slurry. It also promotes steric stabilization, which limits aggregation, thus enhancing the colloidal nature of the lime putty. Overall, these effects are very favorable for the preparation of highly plastic lime mortars with enhanced properties.

Collective motion in quantum many-body systems

Energy Technology Data Exchange (ETDEWEB)

Haemmerling, Jens

2011-06-07

We study the emergence of collective dynamics in the integrable Hamiltonian system of two finite ensembles of coupled harmonic oscillators. After identification of a collective degree of freedom, the Hamiltonian is mapped onto a model of Caldeira-Leggett type, where the collective coordinate is coupled to an internal bath of phonons. In contrast to the usual Caldeira-Leggett model, the bath in the present case is part of the system. We derive an equation of motion for the collective coordinate which takes the form of a damped harmonic oscillator. We show that the distribution of quantum transition strengths induced by the collective mode is determined by its classical dynamics. This allows us to derive the spreading for the collective coordinate from first principles. After that we study the interplay between collective and incoherent single-particle motion in a model of two chains of particles whose interaction comprises a non-integrable part. In the perturbative regime, but for a general form of the interaction, we calculate the Fourier transform of the time correlation for the collective coordinate. We obtain the remarkable result that it always has a unique semi-classical interpretation. We show this by a proper renormalization procedure which also allows us to map the non-integrable system to the integrable model of Caldeira-Leggett-type considered previously in which the bath is part of the system.

Calculation of embodied energy in Sino-USA trade: 1997–2011

International Nuclear Information System (INIS)

Yang, Ranran; Long, Ruyin; Yue, Ting; Shi, Haihong

2014-01-01

In order to find efficient trade measures to reduce China's energy consumption and to provide theoretical support for the climate talks between China and America, we investigate the impact of Sino-USA trade on energy consumption from the perspective of embodied energy. An Environmental Input–Output Life Cycle Assessment (EIO-LCA) model was established to calculate the total energy consumption coefficient, the direct consumption coefficient and the complete consumption coefficient of the sectors of the national economies of China and America. After taking into consideration the data of every sector of the national economy in Sino-USA trade, energy embodied in the import and export trade between China and America was calculated to verify the real energy flows in Sino-USA trade. The research results suggest the following: China is the net exporter of embodied energy in Sino-USA trade, and coal, crude oil and natural gas are the major components. In 1997–2011, the net exports of China's embodied energy totaled 1523,082,200 t of standard coal, the amount of China's energy consumption increased by 895,527,900 t of standard coal, and America's energy consumption decreased by 11,871,200 t of standard coal as a result of Sino-USA trade. On this basis, corresponding policies and recommendations are proposed. - Highlights: • An EIO-LCA model is established to examine China's embodied energy in Sino-USA trade. • Embodied energy is calculated from the perspective of energy sources. • China is found to be the net exporter of embodied energy in Sino-USA trade. • Coal, crude oil and natural gas are the major components of China's net embodied energy exports. • China's energy consumption has increased and America's has shifted to China in Sino-USA trade

Fossil fuels and air pollution in USA after the Clean Air Act

International Nuclear Information System (INIS)

Chuveliov, A.V.

1990-01-01

This paper addresses environmental issues in the USA after the Clean Air Act. Economic damage assessment to population and environment due to air pollution from stationary and mobile sources producing and utilizing fossil fuels in the USA for the period of 1970--1986 is determined and discussed. A comparison of environmental damage assessments for the USA and USSR is provided. The paper also addresses ecologo-economical aspects of hydrogen energy and technology. The effectiveness of hydrogen use in ferrous metallurgy and motor vehicles in the USA is determined and discussed

USA näeb tuumaenergias oma võimalust / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

USA presidendi George W. Bushi ja energiaministri asetäitja Clay Sell'i sõnul on USA administratsiooni uue globaalse tuumaenergia partnerluse programmi eesmärgiks leida võimalusi maailma üha suurenevate energiavajaduste rahuldamiseks tuumaenergia abil. Lisa: Tuumaenergia

CaEDTA vs CaEDTA plus BAL to treat children with elevated blood lead levels.

Science.gov (United States)

O'Connor, M E

1992-07-01

The effectiveness of CaEDTA alone vs CaEDTA plus BAL was compared retrospectively in a group of 72 children with lead levels between 2.41 mumol/L (50 micrograms/dL) and 2.90 mumol/L (60 micrograms/dL). The children who received both drugs had higher median zinc protoporphyrin (ZnP) concentrations at the initiation of therapy than children who received CaEDTA alone (160 micrograms/dL vs 96 micrograms/dL, p less than .01). There was a significantly increased incidence of vomiting and abnormal liver-function test results in the children who received both drugs. The children who received CaEDTA alone had a greater percent mean fall in lead level at one to three weeks postchelation (30.5% vs 18.1%, p less than .05). Children who received both CaEDTA and BAL had a greater percent decrease in ZnP at four to eight months postchelation, but there was no difference in percent decrease in lead levels. Children who received both drugs also had a greater number of repeat courses of chelation by six months. The addition of BAL to CaEDTA for treatment of children with lead levels of 2.41 mumol/L (50 micrograms/dL) to 2.90 mumol/L (60 micrograms/dL) produced greater toxicity and does not seem to prevent repeat chelations within six months.

The evolution of nuclear power in the USA

International Nuclear Information System (INIS)

Davis, W.K.

1983-01-01

The development and deployment of commercial nuclear power in the USA has been impressive since the programme began in the early 1950s. Today there are 73 commercial power reactors operating in the USA with combined capacity of about 56 GW(e). By 1990, an additional 64 nuclear power plants with a total capacity of approximately 123 GW(e) will be in operation supplying about 25% of US electrical energy requirements. Despite the cancellation of 91 new units since 1972 and lack of any new plant orders, there is a clear and continuing role for nuclear energy in the USA if we are to experience continued economic growth. New growth for US nuclear industry requires several things to happen. The prospective demand for electricity and new generating plants must increase; the US Government must show that it will fulfill its responsibilities to dispose of nuclear waste; a more stable regulatory process must be implemented so that nuclear power plants can be built with a reasonable degree of assurance beforehand as to what the final design, cost and schedule will be. President Reagan's July 1981 policy statement on Non-Proliferation and Peaceful Nuclear Co-operation and October 1981 Domestic Nuclear Policy Statement provide the policy framework necessary for the USA to maintain a viable domestic nuclear industry to enable nuclear power to make its essential contribution to future US energy needs and to re-establish the USA as a predictable and reliable partner for international nuclear co-operation under adequate safeguards. The US Government has structured its programmes and activities to implement these policies and initiatives. (author)

Ca2+ pump and Ca2+/H+ antiporter in plasma membrane vesicles isolated by aqueous two-phase partitioning from corn leaves

International Nuclear Information System (INIS)

Kasai, M.; Muto, S.

1990-01-01

Plasma membrane vesicles, which are mostly right side-out, were isolated from corn leaves by aqueous two-phase partitioning method. Characteristics of Ca2+ transport were investigated after preparing inside-out vesicles by Triton X-100 treatment. 45Ca2+ transport was assayed by membrane filtration technique. Results showed that Ca2+ transport into the plasma membrane vesicles was Mg-ATP dependent. The active Ca2+ transport system had a high affinity for Ca2+(Km(Ca2+) = 0.4 microM) and ATP(Km(ATP) = 3.9 microM), and showed pH optimum at 7.5. ATP-dependent Ca2+ uptake in the plasma membrane vesicles was stimulated in the presence of Cl- or NO3-. Quenching of quinacrine fluorescence showed that these anions also induced H+ transport into the vesicles. The Ca2+ uptake stimulated by Cl- was dependent on the activity of H+ transport into the vesicles. However, carbonylcyanide m-chlorophenylhydrazone (CCCP) and VO4(3-) which is known to inhibit the H+ pump associated with the plasma membrane, canceled almost all of the Cl(-)-stimulated Ca2+ uptake. Furthermore, artificially imposed pH gradient (acid inside) caused Ca2+ uptake into the vesicles. These results suggest that the Cl(-)-stimulated Ca2+ uptake is caused by the efflux of H+ from the vesicles by the operation of Ca2+/H+ antiport system in the plasma membrane. In Cl(-)-free medium, H+ transport into the vesicles scarcely occurred and the addition of CCCP caused only a slight inhibition of the active Ca2+ uptake into the vesicles. These results suggest that two Ca2+ transport systems are operating in the plasma membrane from corn leaves, i.e., one is an ATP-dependent active Ca2+ transport system (Ca2+ pump) and the other is a Ca2+/H+ antiport system. Little difference in characteristics of Ca2+ transport was observed between the plasma membranes isolated from etiolated and green corn leaves

Chapter 9: The rock coast of the USA

Science.gov (United States)

Hapke, Cheryl J.; Adams, Peter N.; Allan, Jonathan; Ashton, Andrew; Griggs, Gary B.; Hampton, Monty A.; Kelly, Joseph; Young, Adam P.

2014-01-01

The coastline of the USA is vast and comprises a variety of landform types including barrier islands, mainland beaches, soft bluffed coastlines and hard rocky coasts. The majority of the bluffed and rocky coasts are found in the northeastern part of the country (New England) and along the Pacific coast. Rocky and bluffed landform types are commonly interspersed along the coastline and occur as a result of relative lowering of sea level from tectonic or isostatic forcing, which can occur on timescales ranging from instantaneous to millenia. Recent research on sea cliffs in the contiguous USA has focused on a broad range of topics from documenting erosion rates to identifying processes and controls on morphology to prediction modelling. This chapter provides a detailed synthesis of recent and seminal research on rocky coast geomorphology along open-ocean coasts of the continental United States (USA).

Rice nimetas Iraani USA suurimaks väljakutseks / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

USA välisminister Condoleezza Rice sõnas välissuhete komitees esinedes, et tuumatehnoloogiale ja piirkondlikule hegemooniale suuna võtnud Iraan on USA-le Lähis-Idas suurim strateegiline väljakutse. Vt. samas: Pariis: Iraanil on sõjaline tuumaprojekt

Tropical Trametes lactinea is widely distributed in the eastern USA

Czech Academy of Sciences Publication Activity Database

Vlasák, Josef; Kout, J.

2011-01-01

Roč. 115, č. 1 (2011), s. 271-279 ISSN 0093-4666 Institutional research plan: CEZ:AV0Z50510513 Keywords : Basidiomycota, USA new record, taxonomy * USA new record * taxonomy Subject RIV: EF - Botanics Impact factor: 0.709, year: 2011

CaWingz user's guide

International Nuclear Information System (INIS)

Cha, Ben-chin.

1994-01-01

This document assumes that you have read and understood the Wingz user's manuals. CaWingz is an external Wingz program which, when combined with a set of script files, provides easy-to-use EPICS channel access interface functions for Wingz users. The external function run allows Wingz user to invoke any Unix processor within caWingz. Few additional functions for accessing static database field and monitoring of value change event is available for EPICS users after release 3.11. The functions, script files, and usage are briefly described in this document. The script files supplied here serve as examples only. Users are responsible for generating their own spreadsheet and script files. CaWingz communicates with IOC through channel access function calls

USA kindral ei soovita sõjalist kohalolekut Iraagis niipea vähendada / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2007-01-01

USA vägede juhataja Iraagis David Petraeus ja suursaadik Iraagis Ryan Cocker käsitlesid USA Esindajatekoja relvajõudude ja väliskomitee ühisistungil olukorda Iraagis ja USA sõjalist kohalolekut. Nad soovisid Kongressilt USA vägede säilitamist enam-vähem praegusel tasemel kuni 2008. aasta suveni

Protein Kinase Cα and P-Type Ca2+ Channel CaV2.1 in Red Blood Cell Calcium Signalling

Directory of Open Access Journals (Sweden)

Lisa Wagner-Britz

2013-06-01

Full Text Available Background/Aims: Protein kinase Cα (PKCα is activated by an increase in cytosolic Ca2+ in red blood cells (RBCs. Previous work has suggested that PKCα directly stimulates the CaV2.1 channel, whereas other studies revealed that CaV2.1 is insensitive to activation by PKC. The aim of this study was to resolve this discrepancy. Methods: We performed experiments based on a single cell read-out of the intracellular Ca2+ concentration in terms of Fluo-4 fluorescence intensity and phosphatidylserine exposure to the external membrane leaflet. Measurement modalities included flow cytometry and live cell imaging. Results: Treatment of RBCs with phorbol 12-myristate 13-acetate (PMA led to two distinct populations of cells with an increase in intracellular Ca2+: a weak-responding and a strong-responding population. The EC50 of PMA for the number of cells with Ca2+ elevation was 2.7±1.2 µM; for phosphatidylserine exposure to the external membrane surface, it was 2.8±0.5 µM; and for RBC haemolysis, it was 2.9±0.5 µM. Using pharmacological manipulation with the CaV2.1 inhibitor ω-agatoxin TK and the broad protein kinase C inhibitor Gö6983, we are able to show that there are two independent PMA-activated Ca2+ entry processes: the first is independent of CaV2.1 and directly PKCα-activated, while the second is associated with a likely indirect activation of CaV2.1. Further studies using lysophosphatidic acid (LPA as a stimulation agent have provided additional evidence that PKCα and CaV2.1 are not directly interconnected in a signalling chain. Conclusion: Although we provide evidence for a lack of interaction between PKCα and CaV2.1 in RBCs, further studies are required to decipher the signalling relationship between LPA, PKCα and CaV2.1.

USA panustab keskkonda / Jeffrey Goldstein

Index Scriptorium Estoniae

Goldstein, Jeffrey

2007-01-01

USA uus energiapoliitika kava näeb ette bensiini tarbimise vähendamist järgneva 10 aasta jooksul 20%, mis omakorda vähendab ameeriklaste autodest eralduva süsihappegaasi heitmete kasvu ning vähendab sõltuvust naftast

USA asekaitseminister seisab Eesti eest

Index Scriptorium Estoniae

2010-01-01

Eestis visiidil viibiv USA asekaitseminister poliitika alal Michele Flournoy ütles, et pooldab koostöökohtade otsimist Moskvaga, kuid on kindlal seisukohal, et Venemaa ei tohi end siin piirkonnas kehtestada. Flournoy tunnustas Eesti panust Afganistani ning samuti liitlassuhetesse laiemalt

ÜRO asesekretäri kriitika USA suunal ajas viimase marru / Liise Lehtsalu

Index Scriptorium Estoniae

Lehtsalu, Liise

2006-01-01

ÜRO asesekretär Malloch Brown kritiseeris oma kõnes USA tahtmatust teavitada ameeriklasi ÜRO osast USA välispoliitikas. USA ÜRO-suursaadiku John Boltoni reageering Browni märkustele. Lisa: Rikaste ja vaeste riikide vastuolud

Euroopat väisav Rice kaitseb USA karme võtteid terrorisõjas / Ahto Lobjakas

Index Scriptorium Estoniae

Lobjakas, Ahto, 1970-

2005-01-01

EL päris USA-lt ametlikult aru seoses CIA lennukite liikumisega Euroopas ja spekulatsioonidega salavanglate ümber. USA välisminister Condoleezza Rice teatas avalduses, et USA ei piina vange ega vea neid selleks ühest riigist teise. Analüütikute hinnangul üritab enamik EL-ist konfrontatsiooni USA-ga vältida

Baltimaade kunsti turnee USAs

Index Scriptorium Estoniae

1998-01-01

5. nov.-st USA Lõuna-Carolina osariigis Wellington B. Grey galeriis ja Jenkins Fine Art Center's 13 eesti, läti ja leedu kunstniku näitus, mis hakkab kolme aasta jooksul ringlema Ameerikas. Eksponeeritud fotokunst, video, installatsioon, joonistused. Kuraator Peeter Linnap ja Mari Laanemets peavad ettekande näituse avamisega samal ajal toimuval Fotohariduse Ühingu konverentsil

Valge Maja hämab USA vägede tulevikust Iraagis / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

Kuigi USA president George W. Bush on kõnelenud ja USA vägede ülemjuhataja Iraagis George Casey esitanud konkreetse plaani USA vägede väljatoomisest Iraagist, pole Valge Maja konkreetset plaani ametlikult kinnitanud. Lisa: Sõjatandrilt lahkumine

Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum

Science.gov (United States)

López-Sanjurjo, Cristina I.; Tovey, Stephen C.; Prole, David L.; Taylor, Colin W.

2013-01-01

Summary Most intracellular Ca2+ signals result from opening of Ca2+ channels in the plasma membrane or endoplasmic reticulum (ER), and they are reversed by active transport across these membranes or by shuttling Ca2+ into mitochondria. Ca2+ channels in lysosomes contribute to endo-lysosomal trafficking and Ca2+ signalling, but the role of lysosomal Ca2+ uptake in Ca2+ signalling is unexplored. Inhibition of lysosomal Ca2+ uptake by dissipating the H+ gradient (using bafilomycin A1), perforating lysosomal membranes (using glycyl-L-phenylalanine 2-naphthylamide) or lysosome fusion (using vacuolin) increased the Ca2+ signals evoked by receptors that stimulate inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] formation. Bafilomycin A1 amplified the Ca2+ signals evoked by photolysis of caged Ins(1,4,5)P3 or by inhibition of ER Ca2+ pumps, and it slowed recovery from them. Ca2+ signals evoked by store-operated Ca2+ entry were unaffected by bafilomycin A1. Video-imaging with total internal reflection fluorescence microscopy revealed that lysosomes were motile and remained intimately associated with the ER. Close association of lysosomes with the ER allows them selectively to accumulate Ca2+ released by Ins(1,4,5)P3 receptors. PMID:23097044

77 FR 38039 - Corporation for Travel Promotion (dba Brand USA)

Science.gov (United States)

2012-06-26

... DEPARTMENT OF COMMERCE International Trade Administration Corporation for Travel Promotion (dba Brand USA) AGENCY: International Trade Administration, Commerce. ACTION: Notice of an opportunity for... Corporation for Travel Promotion (Board) (dba Brand USA). The purpose of the Board is to guide the Corporation...

78 FR 53728 - Corporation for Travel Promotion (dba Brand USA)

Science.gov (United States)

2013-08-30

... DEPARTMENT OF COMMERCE International Trade Administration Corporation for Travel Promotion (dba Brand USA) AGENCY: International Trade Administration, U.S. Department of Commerce. ACTION: Notice of an... the Corporation for Travel Promotion (dba Brand USA). The purpose of the Board is to guide the...

78 FR 44531 - Corporation for Travel Promotion (dba Brand USA)

Science.gov (United States)

2013-07-24

... DEPARTMENT OF COMMERCE International Trade Administration Corporation for Travel Promotion (dba Brand USA) AGENCY: International Trade Administration, U.S. Department of Commerce. ACTION: Notice of an... the Corporation for Travel Promotion (dba Brand USA). The purpose of the Board is to guide the...

Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness

Science.gov (United States)

Choi, Soonwook; Yu, Eunah; Lee, Seongwon; Llinás, Rodolfo R.

2015-01-01

In unconscious status (e.g., deep sleep and anesthetic unconsciousness) where cognitive functions are not generated there is still a significant level of brain activity present. Indeed, the electrophysiology of the unconscious brain is characterized by well-defined thalamocortical rhythmicity. Here we address the ionic basis for such thalamocortical rhythms during unconsciousness. In particular, we address the role of CaV3.1 T-type Ca2+ channels, which are richly expressed in thalamic neurons. Toward this aim, we examined the electrophysiological and behavioral phenotypes of mice lacking CaV3.1 channels (CaV3.1 knockout) during unconsciousness induced by ketamine or ethanol administration. Our findings indicate that CaV3.1 KO mice displayed attenuated low-frequency oscillations in thalamocortical loops, especially in the 1- to 4-Hz delta band, compared with control mice (CaV3.1 WT). Intriguingly, we also found that CaV3.1 KO mice exhibited augmented high-frequency oscillations during unconsciousness. In a behavioral measure of unconsciousness dynamics, CaV3.1 KO mice took longer to fall into the unconscious state than controls. In addition, such unconscious events had a shorter duration than those of control mice. The thalamocortical interaction level between mediodorsal thalamus and frontal cortex in CaV3.1 KO mice was significantly lower, especially for delta band oscillations, compared with that of CaV3.1 WT mice, during unconsciousness. These results suggest that the CaV3.1 channel is required for the generation of a given set of thalamocortical rhythms during unconsciousness. Further, that thalamocortical resonant neuronal activity supported by this channel is important for the control of vigilance states. PMID:26056284

Ablation of Ca(V)2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments.

Science.gov (United States)

Mallmann, Robert Theodor; Elgueta, Claudio; Sleman, Faten; Castonguay, Jan; Wilmes, Thomas; van den Maagdenberg, Arn; Klugbauer, Norbert

2013-01-01

Voltage-gated Ca(V)2.1 (P/Q-type) Ca²⁺ channels located at the presynaptic membrane are known to control a multitude of Ca²⁺-dependent cellular processes such as neurotransmitter release and synaptic plasticity. Our knowledge about their contributions to complex cognitive functions, however, is restricted by the limited adequacy of existing transgenic Ca(V)2.1 mouse models. Global Ca(V)2.1 knock-out mice lacking the α1 subunit Cacna1a gene product exhibit early postnatal lethality which makes them unsuitable to analyse the relevance of Ca(V)2.1 Ca²⁺ channels for complex behaviour in adult mice. Consequently we established a forebrain specific Ca(V)2.1 knock-out model by crossing mice with a floxed Cacna1a gene with mice expressing Cre-recombinase under the control of the NEX promoter. This novel mouse model enabled us to investigate the contribution of Ca(V)2.1 to complex cognitive functions, particularly learning and memory. Electrophysiological analysis allowed us to test the specificity of our conditional knock-out model and revealed an impaired synaptic transmission at hippocampal glutamatergic synapses. At the behavioural level, the forebrain-specific Ca(V)2.1 knock-out resulted in deficits in spatial learning and reference memory, reduced recognition memory, increased exploratory behaviour and a strong attenuation of circadian rhythmicity. In summary, we present a novel conditional Ca(V)2.1 knock-out model that is most suitable for analysing the in vivo functions of Ca(V)2.1 in the adult murine forebrain.

A model of cardiac ryanodine receptor gating predicts experimental Ca2+-dynamics and Ca2+-triggered arrhythmia in the long QT syndrome

Science.gov (United States)

Wilson, Dan; Ermentrout, Bard; Němec, Jan; Salama, Guy

2017-09-01

Abnormal Ca2+ handling is well-established as the trigger of cardiac arrhythmia in catecholaminergic polymorphic ventricular tachycardia and digoxin toxicity, but its role remains controversial in Torsade de Pointes (TdP), the arrhythmia associated with the long QT syndrome (LQTS). Recent experimental results show that early afterdepolarizations (EADs) that initiate TdP are caused by spontaneous (non-voltage-triggered) Ca2+ release from Ca2+-overloaded sarcoplasmic reticulum (SR) rather than the activation of the L-type Ca2+-channel window current. In bradycardia and long QT type 2 (LQT2), a second, non-voltage triggered cytosolic Ca2+ elevation increases gradually in amplitude, occurs before overt voltage instability, and then precedes the rise of EADs. Here, we used a modified Shannon-Puglisi-Bers model of rabbit ventricular myocytes to reproduce experimental Ca2+ dynamics in bradycardia and LQT2. Abnormal systolic Ca2+-oscillations and EADs caused by SR Ca2+-release are reproduced in a modified 0-dimensional model, where 3 gates in series control the ryanodine receptor (RyR2) conductance. Two gates control RyR2 activation and inactivation and sense cytosolic Ca2+ while a third gate senses luminal junctional SR Ca2+. The model predicts EADs in bradycardia and low extracellular [K+] and cessation of SR Ca2+-release terminate salvos of EADs. Ca2+-waves, systolic cell-synchronous Ca2+-release, and multifocal diastolic Ca2+ release seen in subcellular Ca2+-mapping experiments are observed in the 2-dimensional version of the model. These results support the role of SR Ca2+-overload, abnormal SR Ca2+-release, and the subsequent activation of the electrogenic Na+/Ca2+-exchanger as the mechanism of TdP. The model offers new insights into the genesis of cardiac arrhythmia and new therapeutic strategies.

Complete genome sequence of community-associated methicillin-resistant Staphylococcus aureus (strain USA400-0051, a prototype of the USA400 clone

Directory of Open Access Journals (Sweden)

Marina Farrel Côrtes

Full Text Available Staphylococcus aureus subsp. aureus, commonly referred as S. aureus, is an important bacterial pathogen frequently involved in hospital- and community-acquired infections in humans, ranging from skin infections to more severe diseases such as pneumonia, bacteraemia, endocarditis, osteomyelitis, and disseminated infections. Here, we report the complete closed genome sequence of a community-acquired methicillin-resistant S. aureus strain, USA400-0051, which is a prototype of the USA400 clone.

CA 19-9 and CA 125 as potential predictors of disease recurrence in resectable lung adenocarcinoma.

Directory of Open Access Journals (Sweden)

Sofi Isaksson

Full Text Available Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC, recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease.Blood samples were collected prior to lung cancer surgery from 107 patients with stage I-III lung adenocarcinoma surgically treated at Lund University hospital, Lund, Sweden, between 2005 and 2011. The serum tumor markers Carcinoembryonic antigen (CEA, Neuron-specific enolase (NSE, Cancer antigen 125 (CA 125, Human epididymis protein 4 (HE4 and Carbohydrate antigen (CA 19-9 were analyzed retrospectively and clinical follow-up data were collected from patient charts. Forty (37% patients were diagnosed with recurrent disease.Sixty-eight (64% patients had at least one elevated tumor marker prior to surgery. In analysis of disease-free survival (DFS, CA 125 and/or CA 19-9 were significantly associated with recurrent disease adjusted to stage and adjuvant treatment (hazard ratio 2.8, 95% confidence interval 1.4-5.7, p = 0.006.High pre-operative serum CA 19-9 and/or CA 125 might indicate an increased incidence of recurrent disease in resectable lung adenocarcinomas.

The investigation of minoxidil-induced [Ca2+]i rises and non-Ca2+-triggered cell death in PC3 human prostate cancer cells.

Science.gov (United States)

Chen, I-Shu; Chou, Chiang-Ting; Liu, Yuan-Yuarn; Yu, Chia-Cheng; Liang, Wei-Zhe; Kuo, Chun-Chi; Shieh, Pochuen; Kuo, Daih-Huang; Chen, Fu-An; Jan, Chung-Ren

2017-02-01

Minoxidil is clinically used to prevent hair loss. However, its effect on Ca 2+ homeostasis in prostate cancer cells is unclear. This study explored the effect of minoxidil on cytosolic-free Ca 2+ levels ([Ca 2+ ] i ) and cell viability in PC3 human prostate cancer cells. Minoxidil at concentrations between 200 and 800 μM evoked [Ca 2+ ] i rises in a concentration-dependent manner. This Ca 2+ signal was inhibited by 60% by removal of extracellular Ca 2+ . Minoxidil-induced Ca 2+ influx was confirmed by Mn 2+ -induced quench of fura-2 fluorescence. Pre-treatment with the protein kinase C (PKC) inhibitor GF109203X, PKC activator phorbol 12-myristate 13 acetate (PMA), nifedipine and SKF96365 inhibited minoxidil-induced Ca 2+ signal in Ca 2+ containing medium by 60%. Treatment with the endoplasmic reticulum Ca 2+ pump inhibitor 2,5-ditert-butylhydroquinone (BHQ) in Ca 2+ -free medium abolished minoxidil-induced [Ca 2+ ] i rises. Conversely, treatment with minoxidil abolished BHQ-induced [Ca 2+ ] i rises. Inhibition of phospholipase C (PLC) with U73122 abolished minoxidil-evoked [Ca 2+ ] i rises. Overnight treatment with minoxidil killed cells at concentrations of 200-600 μM in a concentration-dependent fashion. Chelation of cytosolic Ca 2+ with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid/AM (BAPTA/AM) did not prevent minoxidil's cytotoxicity. Together, in PC3 cells, minoxidil induced [Ca 2+ ] i rises that involved Ca 2+ entry through PKC-regulated store-operated Ca 2+ channels and PLC-dependent Ca 2+ release from the endoplasmic reticulum. Minoxidil-induced cytotoxicity in a Ca 2+ -independent manner.

Diagnostic significance of tumor markers CEA, CA50 and CA19-9 for colorectal cancer

International Nuclear Information System (INIS)

Chen Yumei; Huang Gang

2005-01-01

Objective: To investigate the expression and diagnostic significance of three serum tumor markers (CEA, CA50, CA19-9) in patients with colorectal cancer, with special emphasis on their combined assay. Methods: Serum CEA, CA19-9 levels (with chemiluminescence immunoassay) and CA50 levels (with immunoradiometric assay) were determined in 94 patients with colorectal cancer, 20 patients with benign colorectal disorders and 37 controls. Results: The expressions of the serum tumor markers were significantly higher in patients with colorectal cancer than those in patients with benign colorectal disorders and controls (P<0.05). There was no significant difference between the levels in the latter two groups. CEA assay had the highest sensitivity (57.4%) and specificity (85.9%). Combined assay of the three could enhance both the sensitivity (62.7%) and specificity (96.5%). The serum levels of the markers were significantly higher in patients with colonic cancer than those in patients with rectal cancer (P<0.05). The levels were positively correlated with the size of the growth and stage of the disease. Serum tumor marker levels were also significantly higher in patients with metastasis (regional/distant) than those in patients without metastasis (P<0.05). Conclusion: Determination of serum CEA, CA50 and CA19-9 levels had definite value for the diagnosis and assessment of the pathology as well as biologic behavior colorectal cancer. Combined assay of the three could enhance the diagnostic sensitivity and specificity. (authors)

Study on the diagnostic value of combined determination of serum CA125, CA199 and SIL-2R levels in patients with endometriosis

International Nuclear Information System (INIS)

Yang Jingxiu; Shi Shaohong; Wang Yuping; Xie Xueqin; Qin Jibao

2005-01-01

Objective: To investigate the diagnostic values of combined determination of serum CA125, CA199 and SIL-2R levels in patients with endometriosis. Methods: Serum CA125, CA199 were measured with RIA and SIL-2R levels with ELISA in 54 patients with endometriosis and 35 controls. Results: The serum levels of CA125, CA199 and SIL-2R in patients with endometriosis were significantly higher than those in controls (P<0.01). The sensitivity and speciality of CA125 for endometriosis was 70.2% and 80.4% respectively, the sensitivity and speciality of CA199 for endometriosis was 62.4% and 71.8% respectively, the sensitivity and speciality of SIL-2R was 89.5% and 60.2% respectively. The sensitivity of the combined determination of CA125, CA199 and SIL-2R for endometriosis was 86.8% being significantly higher than that of CA125 and CA199 respectively. Conclusion: Combined determination of the serum CA125, CA199 and SIL-2R levels in serum can increase the diagnostic sensitivity for endometriosis. (authors)

Thermal neutrons thermoluminescence dosimetry using CaF2 + KBr e CaSO4: Dy + Br

International Nuclear Information System (INIS)

Leite, A.M.P.

1979-01-01

Cold-pressed samples of CaF 2 + KBr and CaSO 4 :Dy + KBr have been used in the thermal neutron detection by the thermoluminescence technique. The amount of 100 mg of the TL phosphor added to 80 mg of KBr showed to be the optimum mixture regarding sensitivity as well as the handling of the dosimeters. The detection is based on the self-irradiation of the phosphor by the Br isotopes activated by exposure to a neutron-gama field. The prompt dose and consequentely the gama contribution are erased by post-irradiation thermal annealing. A linear dependence has been found between the TL self-induced signal and the thermal neutron flux in the range 10 6 n.cm -2 .seg -1 -10 -12 n.cm -2 .seg -1 . The minimum detectable fluence has benn determined as 10 9 n.cm -2 and 10 6 n.cm -2 using pellets of CaF 2 + KBr and CaSO 4 :Dy + KBr, respectively. The main results suggest the use of CaSO 4 :Dy + KBr pellets and TL as a complementary technique for thermal neutron detection. (author) [pt

USA passib Iisraeli-Liibanoni konfliktis oma võimalust / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

Mitmete USA ajalehtede andmeil on USA ja Iisrael jõudnud kulisside taga kokkuleppele, et lähipäevadel ei sekku Ühendriigid veel Lähis-Ida konflikti, mis võimaldab Iisraelil jätkata äärmusrühmituse Hezbollah tugipunktide hävitamist

Glucagon releases Ca2+ from a FCCP-sensitive pool

International Nuclear Information System (INIS)

Kraus-Friedmann, N.

1986-01-01

The effects of physiological levels of glucagon on Ca 2+ efflux were examined in the perfused rat liver. Two methods were used to estimate Ca 2+ efflux: (1) prior labeling of the Ca 2+ pools with 45 Ca 2+ , and (2) measurement of perfusate Ca 2+ with atomic absorption. According to both methods, glucagon administration at the physiological level evoked Ca 2+ release. In order to identify the hormone-sensitive Ca 2+ pool, a method employed by several laboratories was used. In this method, mitochondrial Ca 2+ is released by FCCP, (carbonyl-cyanide 4 (trifluoro/methoxy) phenylhydrazone), a mitochondrial uncoupler. The effect of hormones on Ca 2+ release after such uncoupler administration is measured. A decreased release is taken as an indication that the pool is entirely or partially mitochondrial. FCCP released 90 +/- 29 nmoles Ca 2+ /gr wet liver. Glucagon (5 x 10 -9 M) released 107 +/- 45 nmoles Ca 2+ /gr wet liver before and 26 +/- 9 nmoles Ca 2+ /gr wet liver after FCCP. These data indicate that glucagon releases Ca 2+ mostly from the mitochondria

IP3 stimulates CA++ efflux from fusogenic carrot protoplasts

International Nuclear Information System (INIS)

Rincon, M.; Boss, W.F.

1986-01-01

Polyphosphoinositide breakdown plays an important role in signal transduction in animal cells (Berridge and Irvine, 1984, Nature, 312:315). Upon stimulation, phospholipase C hydrolyzes phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate (IP 3 ) and diacylglycerol both of which act as cellular second messengers. IP 3 mobilizes Ca ++ from internal stores, hence the cytosolic free Ca ++ concentration increases and those physiological activities regulated by Ca ++ are stimulated. To test if plant cells also responded to IP 3 , Ca ++ efflux studies were done with fusogenic carrot protoplasts released in EGTA. The protoplasts were preloaded with 45 Ca ++ placed in a Ca ++ -free medium, and efflux determined as 45 Ca ++ loss from the protoplasts. IP 3 (10-20μM) caused enhanced 45 Ca ++ efflux and the response was sustained for at least 15 min. In plants, as in animals, the observed IP 3 -enhanced 45 Ca ++ efflux suggested that IP 3 released Ca ++ from internal stores, and the increased free cytosolic Ca ++ activated Ca ++ pumping mechanisms which restored the Ca ++ concentration in the cytosol to the normal level

Eesti ja USA juhtide kohtumiste peateema on NATO ja demokraatia / Vahur Koorits

Index Scriptorium Estoniae

Koorits, Vahur, 1981-

2006-01-01

USA presidendi George W. Bushi visiidi ajal toimuvatel USA ja Eesti riigijuhtide kohtumistel räägitakse NATO ja demokraatia tulevikust, samuti tulevad kõne alla missioonid Afganistanis ja Iraagis ning eestlaste viisavabadus USA-sse reisimisel. Lisa: Millest kavatsevad riigijuhid kohtumistel rääkida: Ansip, Ilves, Bush. Vt. samas: Bushi visiidi ajal vilksatab Eesti üheks õhtuks ameeriklaste teleekraanidel

President Meri näitas USA-le vabaduse ilu / Daniel Fried ; interv. Kaarel Kaas

Index Scriptorium Estoniae

Fried, Daniel, 1952-

2006-01-01

USA abivälisminister Daniel Fried USA välispoliitika ühest eesmärgist - demokraatia levitamisest maailmas, demokraatia olukorrast Venemaal ning USA ja Venemaa vahelistest suhetest. Lisa: Daniel Fried

Ablation of Ca(V2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments.

Directory of Open Access Journals (Sweden)

Robert Theodor Mallmann

Full Text Available Voltage-gated Ca(V2.1 (P/Q-type Ca²⁺ channels located at the presynaptic membrane are known to control a multitude of Ca²⁺-dependent cellular processes such as neurotransmitter release and synaptic plasticity. Our knowledge about their contributions to complex cognitive functions, however, is restricted by the limited adequacy of existing transgenic Ca(V2.1 mouse models. Global Ca(V2.1 knock-out mice lacking the α1 subunit Cacna1a gene product exhibit early postnatal lethality which makes them unsuitable to analyse the relevance of Ca(V2.1 Ca²⁺ channels for complex behaviour in adult mice. Consequently we established a forebrain specific Ca(V2.1 knock-out model by crossing mice with a floxed Cacna1a gene with mice expressing Cre-recombinase under the control of the NEX promoter. This novel mouse model enabled us to investigate the contribution of Ca(V2.1 to complex cognitive functions, particularly learning and memory. Electrophysiological analysis allowed us to test the specificity of our conditional knock-out model and revealed an impaired synaptic transmission at hippocampal glutamatergic synapses. At the behavioural level, the forebrain-specific Ca(V2.1 knock-out resulted in deficits in spatial learning and reference memory, reduced recognition memory, increased exploratory behaviour and a strong attenuation of circadian rhythmicity. In summary, we present a novel conditional Ca(V2.1 knock-out model that is most suitable for analysing the in vivo functions of Ca(V2.1 in the adult murine forebrain.

Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.

Science.gov (United States)

Wang, Qiongling; Quick, Ann P; Cao, Shuyi; Reynolds, Julia; Chiang, David Y; Beavers, David; Li, Na; Wang, Guoliang; Rodney, George G; Anderson, Mark E; Wehrens, Xander H T

2018-04-01

Duchenne muscular dystrophy patients are prone to ventricular arrhythmias, which may be caused by abnormal calcium (Ca 2+ ) homeostasis and elevated reactive oxygen species. CaMKII (Ca 2+ /calmodulin-dependent protein kinase II) is vital for normal Ca 2+ homeostasis, but excessive CaMKII activity contributes to abnormal Ca 2+ homeostasis and arrhythmias in cardiomyocytes. Reactive oxygen species induce CaMKII to become autonomously active. We hypothesized that genetic inhibition of CaMKII oxidation (ox-CaMKII) in a mouse model of Duchenne muscular dystrophy can alleviate abnormal Ca 2+ homeostasis, thus, preventing ventricular arrhythmia. The objective of this study was to test if selective loss of ox-CaMKII affects ventricular arrhythmias in the mdx mouse model of Duchenne muscular dystrophy. 5-(6)-Chloromethyl-2,7-dichlorodihydrofluorescein diacetate staining revealed increased reactive oxygen species production in ventricular myocytes isolated from mdx mice, which coincides with elevated ventricular ox-CaMKII demonstrated by Western blotting. Genetic inhibition of ox-CaMKII by knockin replacement of the regulatory domain methionines with valines (MM-VV [CaMKII M281/282V]) prevented ventricular tachycardia in mdx mice. Confocal calcium imaging of ventricular myocytes isolated from mdx :MM-VV mice revealed normalization of intracellular Ca 2+ release events compared with cardiomyocytes from mdx mice. Abnormal action potentials assessed by optical mapping in mdx mice were also alleviated by genetic inhibition of ox-CaMKII. Knockout of the NADPH oxidase regulatory subunit p47 phox normalized elevated ox-CaMKII, repaired intracellular Ca 2+ homeostasis, and rescued inducible ventricular arrhythmias in mdx mice. Inhibition of reactive oxygen species or ox-CaMKII protects against proarrhythmic intracellular Ca 2+ handling and prevents ventricular arrhythmia in a mouse model of Duchenne muscular dystrophy. © 2018 American Heart Association, Inc.

Managing an outpatient parenteral antibiotic therapy team: challenges and solutions

OpenAIRE

Nguyen, Hien; Halilovic,Jenana; Christensen,Cinda

2014-01-01

Jenana Halilovic,1 Cinda L Christensen,2 Hien H Nguyen31University of the Pacific Thomas J Long School of Pharmacy, Stockton, CA, USA; 2Department of Pharmaceutical Services, University of California, Davis Health System, Sacramento, CA, USA; 3Division of Infectious Diseases, Section of Hospital Medicine, University of California, Davis Health System, Sacramento, CA, USAAbstract: Outpatient parenteral antimicrobial therapy (OPAT) programs should strive to deliver safe, cost effective, and hig...

Existence of Three Positive Solutions to Some p-Laplacian Boundary Value Problems

Directory of Open Access Journals (Sweden)

Moulay Rchid Sidi Ammi

2013-01-01

Full Text Available We obtain, by using the Leggett-Williams fixed point theorem, sufficient conditions that ensure the existence of at least three positive solutions to some p-Laplacian boundary value problems on time scales.

Cation-exchange antibody labeling for simultaneous electrochemical detection of tumor markers CA15-3 and CA19-9

International Nuclear Information System (INIS)

Wang, Guangjie; Qing, Yi; Shan, Jinlu; Jin, Feng; Wang, Dong; Yuan, Ruo

2013-01-01

We report on a new kind of non-covalent multi-label electrochemical immunoassay that was applied to simultaneously quantify the tumor markers CA15-3 and CA19-9. The method employs a nanohybrid composed of an ionomer and conductive titanium dioxide nanoparticles that act as a matrix support for the antibodies. The two antibodies (anti-CA153 and anti-CA199) were labeled (a) with a cobaltous dipyridine complex, and (b) with methylene blue. Labeling is based on cation-exchange interaction rather than on covalent conjugation. The redox potentials of the two labels are separated by an interval of 0.3 V. The resulting sandwich-type immunosensor was read out by differential pulse voltammetry. The potential sites and currents of the two redox probes reflect the concentration of the two analytes. The two analytes were determined with a detection limit of 1.6 U mL −1 for CA19-9, and of 0.3 U mL −1 for CA15-3 (author)

Mati Vanni firma Neoqi paneb USAs saunad püsti

Index Scriptorium Estoniae

2009-01-01

Ärimees Mati Vanni firma Neoqi saunakomplekse Cube paigaldatakse tänavu mitmesse USA firma KWC America salongi, seni on Neoqi lõõgastusseadmeid müüdud rohkem kui 50 riiki. USA firma Sybaritic hagist Neoqi vastu ja Neoqi avaldusest Sybariticu tegevuse kohta, saavutatud leppest

Distribution, hosts and identification of Meloidogyne partityla in the USA

Science.gov (United States)

Pecan, Carya illinoensis, is an economically important nut crop and member of the Juglandaceae native to the southern USA. Discovered in South Africa in 1986, Meloidogyne partityla was first found infecting pecan in USA in 1996 and currently occurs in Texas, New Mexico, Georgia, Arizona, Oklahoma a...

Fidelity of the Sr/Ca proxy in recording ocean temperature in the western Atlantic coral Siderastrea siderea

Science.gov (United States)

Kuffner, Ilsa B.; Roberts, Kelsey E.; Flannery, Jennifer A.; Morrison, Jennifer M.; Richey, Julie N.

2017-01-01

Massive corals provide a useful archive of environmental variability, but careful testing of geochemical proxies in corals is necessary to validate the relationship between each proxy and environmental parameter throughout the full range of conditions experienced by the recording organisms. Here we use samples from a coral-growth study to test the hypothesis that Sr/Ca in the coral Siderastrea siderea accurately records sea-surface temperature (SST) in the subtropics (Florida, USA) along 350 km of reef tract. We test calcification rate, measured via buoyant weight, and linear extension (LE) rate, estimated with Alizarin Red-S staining, as predictors of variance in the Sr/Ca records of 39 individual S. siderea corals grown at four outer-reef locations next to in-situ temperature loggers during two, year-long periods. We found that corals with calcification rates corals that passed this quality control step, the Sr/Ca-SST proxy performed well in estimating mean annual temperature across three sites spanning 350 km of the Florida reef tract. However, there was some evidence that extreme temperature stress in 2010 (cold snap) and 2011 (SST above coral-bleaching threshold) may have caused the corals not to record the temperature extremes. Known stress events could be avoided during modern calibrations of paleoproxies.Plain Language SummaryCoral skeletons are used to decipher past environmental conditions in the ocean because they live for centuries and produce annual growth bands much like tree rings. Along with measuring coral growth rates in the past, coral skeletons can be chemically sampled to get even more detailed information, like past seawater temperatures. In this study we tested the validity of the strontium-to-calcium (Sr/Ca) temperature proxy in the Massive Starlet Coral (Siderastrea siderea) by sampling 39 corals that were grown in the ocean right next to instruments recording underwater temperature. We found that, as long as corals with very slow growth

Juvenile Hippocampal CA2 Region Expresses Aggrecan

Directory of Open Access Journals (Sweden)

Asako Noguchi

2017-05-01

Full Text Available Perineuronal nets (PNNs are distributed primarily around inhibitory interneurons in the hippocampus, such as parvalbumin-positive interneurons. PNNs are also present around excitatory neurons in some brain regions and prevent plasticity in these neurons. A recent study demonstrated that PNNs also exist around mouse hippocampal pyramidal cells, which are the principle type of excitatory neurons, in the CA2 subregion and modulate the excitability and plasticity of these neurons. However, the development of PNNs in the CA2 region during postnatal maturation was not fully investigated. This study found that a main component of PNNs, aggrecan, existed in the pyramidal cell layer of the putative CA2 subarea prior to the appearance of the CA2 region, which was defined by the CA2 marker protein regulator of G protein signaling 14 (RGS14. We also found that aggrecan immunoreactivity was more evident in the anterior sections of the CA2 area than the posterior sections, which suggests that the function of CA2 PNNs varies along the anterior-posterior axis.

Avian metapneumovirus in the USA

Science.gov (United States)

In the United States of America (USA), avian metapneumovirus (aMPV) causes an upper respiratory tract infection in turkeys; no outbreaks have been reported in commercial chicken flocks. Typical clinical signs of the disease in turkey poults include coughing, sneezing, nasal discharge, tracheal rale...

Mucins CA 125, CA 19.9, CA 15.3 and TAG-72.3 as tumor markers in patients with lung cancer: comparison with CYFRA 21-1, CEA, SCC and NSE.

Science.gov (United States)

Molina, Rafael; Auge, Jose Maria; Escudero, Jose Miguel; Marrades, Ramon; Viñolas, Nuria; Carcereny, Emilio; Ramirez, Jose; Filella, Xavier

2008-01-01

Tumor marker serum levels were prospectively studied in 289 patients with suspected, but unconfirmed, lung cancer and in 513 patients with lung cancer [417 non-small cell lung cancer (NSCLC) patients and 96 small cell lung cancer (SCLC) patients]. In patients with benign disease, abnormal serum levels were found for the following tumor markers: CEA (in 6.6% of patients); CA 19.9 (6.2%); CA 125 (28.7%); NSE (0.7%); CYFRA (8.7%); TAG-72.3 (4.2%); SCC (3.5%), and CA 15.3 (3.5%). Excluding patients with renal failure or liver diseases, tumor marker specificity improved with abnormal levels in 0.5% for NSE, 0.9% for SCC, 2.8% for CEA, CA 15.3 and TAG-72.3, 3.8% for CA 19.9, 4.2% for CYFRA and 21.4% for CA 125. Excluding CA 125, one of the markers was abnormal in 15% of patients without malignancy. Tumor marker sensitivity was related to cancer histology and tumor extension. NSE had the highest sensitivity in SCLC and CYFRA and CEA in NSCLC. Significantly higher concentrations of CEA, SCC, CA 125, CA 15.3 and TAG-72.3 were found in NSCLC than in SCLC. Likewise, significantly higher CEA (p tumors. Using a combination of 3 tumor markers (CEA, CYFRA 21-1 in all histologies, SCC in squamous tumors and CA 15.3 in adenocarcinomas), a high sensitivity may be achieved in all histological types. Tumor markers may be useful in the histological differentiation of NSCLC and SCLC. Using specific criteria for the differentiation of SCLC and NSCLC, the sensitivity was 84.2 and 68.8%, the specificity was 93.8 and 99.7%, the positive predictive value was 98.3 and 98.5% and the negative predictive value was 57.7 and 93.3%, respectively. Copyright 2008 S. Karger AG, Basel.

High temperature hydrogenation of CaC6

International Nuclear Information System (INIS)

Srinivas, G.; Howard, C.A.; Skipper, N.T.; Bennington, S.M.; Ellerby, M.

2009-01-01

The structure and superconducting properties of high temperature hydrogenated calcium-graphite intercalation compound, CaC 6 have been investigated using room temperature X-ray diffraction, and temperature and field dependence of magnetisation. It is found that the hydrogenation can only decompose the CaC 6 phase, and generate a mixture of CaH 2 and graphite as the final compound. The hydrogenation of CaC 6 also reveals a degradation of its superconducting properties. The experimental results are discussed in detail and it is found that the formation of stable CaH 2 and deintercalation are the main source for observed phase separation and suppression in superconductivity.

Plasma membrane Ca2+-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+/CaM-dependent serine kinase.

Science.gov (United States)

Andrews, Rachel E; Galileo, Deni S; Martin-DeLeon, Patricia A

2015-11-01

Deletion of the gene encoding the widely conserved plasma membrane calcium ATPase 4 (PMCA4), a major Ca(2+) efflux pump, leads to loss of sperm motility and male infertility in mice. PMCA4's partners in sperm and how its absence exerts its effect on fertility are unknown. We hypothesize that in sperm PMCA4 interacts with endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) which are rapidly activated by Ca(2+), and that these fertility-modulating proteins are present in prostasomes, which deliver them to sperm. We show that in human sperm PMCA4 is present on the acrosome, inner acrosomal membrane, posterior head, neck, midpiece and the proximal principal piece. PMCA4 localization showed inter- and intra-individual variation and was most abundant at the posterior head/neck junction, co-localizing with NOSs. Co-immunoprecipitations (Co-IP) revealed a close association of PMCA4 and the NOSs in Ca(2+) ionophore-treated sperm but much less so in uncapacitated untreated sperm. Fluorescence resonance energy transfer (FRET) showed a similar Ca(2+)-related association: PMCA4 and the NOSs are within 10 nm apart, and preferentially so in capacitated, compared with uncapacitated, sperm. FRET efficiencies varied, being significantly (P < 0.001) higher at high cytosolic Ca(2+) concentration ([Ca(2+)]c) in capacitated sperm than at low [Ca(2+)]c in uncapacitated sperm for the PMCA4-eNOS complex. These dynamic interactions were not seen for PMCA4-nNOS complexes, which had the highest FRET efficiencies. Further, along with Ca(2+)/CaM-dependent serine kinase (CASK), PMCA4 and the NOSs are present in the seminal plasma, specifically in prostasomes where Co-IP showed complexes similar to those in sperm. Finally, flow cytometry demonstrated that following co-incubation of sperm and seminal plasma, PMCA4 and the NOSs can be delivered in vitro to sperm via prostasomes. Our findings indicate that PMCA4 interacts simultaneously with the NOSs preferentially at

Afganistan ja USA tülitsevad vangide ja oopiumi pärast / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2005-01-01

USA presidendi George W. Bushiga kohtumise järel nõudis Afganistani president Hamid Karzai USA käes olevate Afganistani vangide väljaandmist, ta oli nördinud teadete üle, kuidas vange on koheldud. Karzai nõudis kontrolli Afganistanis viibivate USA sõdurite üle ja relvastatud reidide lõpetamist afgaanide kodudesse. Lisa: USA ründab Afganistani narkoäri

Distinct roles of two ceramide synthases, CaLag1p and CaLac1p, in the morphogenesis of Candida albicans

DEFF Research Database (Denmark)

Cheon, Seon Ah; Bal, Jyotiranjan; Song, Yunkyoung

2012-01-01

p) and Lac1p (CaLac1p) are functionally distinct. Lack of CaLag1p, but not CaLac1p, caused severe defects in the growth and hyphal morphogenesis of C. albicans. Deletion of CaLAG1 decreased expression of the hypha-specific HWP1 and ECE1 genes. Moreover, overexpression of CaLAG1 induced pseudohyphal...... growth in this organism under non-hypha-inducing conditions, suggesting that CaLag1p is necessary for relaying signals to induce hypha-specific gene expression. Analysis of ceramide and sphingolipid composition revealed that CaLag1p predominantly synthesizes ceramides with C24:0/C26:0 fatty acid moieties...

Assessment of the diagnostic value of combined determination of serum CA199 CA125 and CEA in patients with cancer of pancreas

International Nuclear Information System (INIS)

Wu Congshan; Liu Xugui

2005-01-01

Objective: To assess the diagnostic value of combined determination of serum CA199, CA125 and CEA for cancer of pancreas. Methods: Serum CA199, CA125 and CEA levels were detected with CLIA in 32 patients with cancer of pancreas and 36 controls. Results: Positive detection rate of CA199 in patients with cancer of pancreas was 90.6% (29/32). Positive rate for CA125 and CEA was 65.6% (21/32) and 46.9% (15/32) respectively. With combined determination of these 3 tumor markers, the positive rate was 96.9% (31/32). The mean content of serum CA199 after successful operation (32.5±8.4U/ml) was significantly lower than that before operation (840.2 ± 102.5U/ml) (P<0.01). Conclusion: Combined determination of CA199, CA125 and CEA would improve the detection rate of cancer of pancreas and post-operative changes of CA199 could be of prognostic value. (authors)

78 FR 64020 - Manufacturer of Controlled Substances, Notice of Registration, Siegfried USA, LLC

Science.gov (United States)

2013-10-25

..., Notice of Registration, Siegfried USA, LLC The Notice dated July 23, 2013, and published in the Federal Register on August 1, 2013, 78 FR 46613, page 18338, Siegfried (USA), LLC., 33 Industrial Park Road...), and Poppy Straw Concentrate (9670). On August 6, 2013, Siegfried (USA), LLC., subsequently withdrew...

Astragalus Granule Prevents Ca2+ Current Remodeling in Heart Failure by the Downregulation of CaMKII

Directory of Open Access Journals (Sweden)

Sinai Li

2017-01-01

Full Text Available Background. Astragalus was broadly used for treating heart failure (HF and arrhythmias in East Asia for thousands of years. Astragalus granule (AG, extracted from Astragalus, shows beneficial effect on the treatment of HF in clinical research. We hypothesized that administration of AG prevents the remodeling of L-type Ca2+ current (ICa-L in HF mice by the downregulation of Ca2+/calmodulin-dependent protein kinase II (CaMKII. Methods. HF mice were induced by thoracic aortic constriction (TAC. After 4 weeks of AG treatment, cardiac function and QT interval were evaluated. Single cardiac ventricular myocyte was then isolated and whole-cell patch clamp was used to record action potential (AP and ICa-L. The expressions of L-type calcium channel alpha 1C subunit (Cav1.2, CaMKII, and phosphorylated protein kinase A (p-PKA were examined by western blot. Results. The failing heart manifested distinct electrical remodeling including prolonged repolarization time and altered ICa-L kinetics. AG treatment attenuated this electrical remodeling, supported by AG-related shortened repolarization time, decreased peak ICa-L, accelerated ICa-L inactivation, and positive frequency-dependent ICa-L facilitation. In addition, AG treatment suppressed the overexpression of CaMKII, but not p-PKA, in the failing heart. Conclusion. AG treatment protected the failing heart against electrical remodeling and ICa-L remodeling by downregulating CaMKII.

Ca-Dependent Folding of Human Calumenin

Science.gov (United States)

Mazzorana, Marco; Hussain, Rohanah; Sorensen, Thomas

2016-01-01

Human calumenin (hCALU) is a six EF-hand protein belonging to the CREC family. As other members of the family, it is localized in the secretory pathway and regulates the activity of SERCA2a and of the ryanodine receptor in the endoplasmic reticulum (ER). We have studied the effects of Ca2+ binding to the protein and found it to attain a more compact structure upon ion binding. Circular Dichroism (CD) measurements suggest a major rearrangement of the protein secondary structure, which reversibly switches from disordered at low Ca2+ concentrations to predominantly alpha-helical when Ca2+ is added. SAXS experiments confirm the transition from an unfolded to a compact structure, which matches the structural prediction of a trilobal fold. Overall our experiments suggest that calumenin is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range. PMID:26991433

Ca isotope fractionation and Sr/Ca partitioning associated with anhydrite formation at mid-ocean ridge hydrothermal systems: An experimental approach

Science.gov (United States)

Syverson, D. D.; Scheuermann, P.; Pester, N. J.; Higgins, J. A.; Seyfried, W. E., Jr.

2016-12-01

The elemental and isotopic mass balance of Ca and Sr between seawater and basalt at mid-ocean ridge (MOR) hydrothermal systems is an integrated reflection of the various physiochemical processes, which induce chemical exchange, in the subseafloor. Specifically, the processes of anhydrite precipitation and recrystallization are recognized to be important controls on governing the Ca and Sr elemental and isotope compositions of high temperature vent fluids, however, few experimental data exist to constrain these geochemical effects. Thus, to better understand the associated Sr/Ca partitioning and Ca isotope fractionation and rate of exchange between anhydrite and dissolved constituents, anhydrite precipitation and recrystallization experiments were performed at 175, 250, and 350°C and 500 bar at chemical conditions indicative of active MOR hydrothermal systems. The experimental data suggest that upon entrainment of seawater into MOR hydrothermal systems, anhydrite will precipitate rapidly and discriminate against the heavy isotopes of Ca (Δ44/40Ca(Anh-Fluid) = -0.68 - -0.25 ‰), whereas Sr/Ca partitioning depends on the saturation state of the evolving hydrothermal fluid with respect to anhydrite at each PTX (KD(Anh-Fluid) = 1.24 - 0.55). Coupling experimental constraints with the temperature gradient inferred for high temperature MOR hydrothermal systems in the oceanic crust, data suggest that the Ca isotope and Sr elemental composition of anhydrite formed near the seafloor will be influenced by disequilibrium effects, while, at higher temperatures further into the oceanic crust, anhydrite will be representative of equilibrium Sr/Ca partitioning and Ca isotope fractionation conditions. These experimental observations are consistent with analyzed Sr/Ca and Ca isotope compositions of anhydrites and vent fluids sampled from modern MOR hydrothermal systems1,2 and can be used to further constrain the geochemical effects of hydrothermal circulation in the oceanic crust

Usefulness of CA 130 kit based on IRMA

International Nuclear Information System (INIS)

Fujii, Takashi; Kimura, Yoshiko; Ata, Mariko; Miyagawa, Naoko; Iio, Atsushi; Hamamoto, Ken

1988-01-01

Immunoradiometric assay for CA 130 was fundamentally and clinically evaluated using a commercially available D-7111 kit. Incubation time was 4 hr with the present CA 133 kit as compared with 16 - 24 hr with conventional CA 125 kit. Laboratory performance of CA 130 kit was satisfactory for standard curve, reproducibility, and recovery test. There was well correlation between the present CA 130 kit and CA 125 kit (r = 0.931). The concentration of CA 130 in the serum was significantly higher in healthy women than men (17.3 +- 10.5 U/ml vs 9.6 +- 5.1 U/ml). Serum CA 130 levels tended to decrease with aging, regardless of sex. These levels were changeable with menstrual cycle ; i.e., these were significantly higher during menstrual phase (24.2 +- 9.0 U/ml) and significantly lower during ovulatory phase (10.9 +- 2.4 U/ml) and during menopause (12.1 +- 3.4 U/ml). Cut off serum CA 130 levels were defined as 20 U/ml for men and 38 U/ml for women. Positive rate for CA 130 was the highest in cases of ovarian cancer (80 %), followed by endometrial cancer (50 %), pancreatic cancer (47 %), benign ovarian tumor (44 %), and lung cancer (39 %). (Namekawa, K.)

Two-phonon E1 excitations in {sup 40}Ca and {sup 140}Ce

Energy Technology Data Exchange (ETDEWEB)

Baldenhofer, Martin; Derya, Vera; Endres, Janis; Hennig, Andreas; Zilges, Andreas [Institute for Nuclear Physics, University of Cologne (Germany); Loeher, Bastian; Savran, Deniz [ExtreMe Matter Institute EMMI and Research Division, GSI, Darmstadt (Germany); Frankfurt Institute for Advanced Studies FIAS, Frankfurt (Germany); Tornow, Werner [Department of Physics, Duke University (United States)

2014-07-01

The coupling of a quadrupole- and an octupole-vibrational excitation results in a quintuplet of J{sup π} = 1{sup -} to 5{sup -} vibrational states with two-phonon structure. Candidates for harmonic two-phonon excitations are found energetically in the vicinity of the sum of the constituent excitation energies. Their structure can be tested by studying their γ-decay behavior in detail. We studied candidates for two-phonon E1 excitations in two nuclei of different mass, namely {sup 40}Ca and {sup 140}Ce, with the high-efficiency γ{sup 3} setup [1] at the High Intensity γ-ray Source facility at the Triangle Universities Nuclear Laboratory in Durham, USA. The mono-energetic γ-ray beam allows for a selective excitation of the states of interest. In combination with the γ{sup 3} setup, on the one hand, a high efficiency for γ-ray detection is achieved by an array of HPGe and LaBr detectors, and, on the other hand, the analysis of γ-γ coincidences is possible.

Ca 125 and Ca 19-9: two cancer-associated sialylsaccharide antigens on a mucus glycoprotein from human milk.

Science.gov (United States)

Hanisch, F G; Uhlenbruck, G; Dienst, C; Stottrop, M; Hippauf, E

1985-06-03

The cancer-associated antigens Ca 125 and Ca 19-9 were demonstrated by radioimmunoassay to form structural units of a mucus glycoprotein in human milk taken from healthy women four days after parturition. The glycoprotein precipitated with the casein fraction at pH 4.6 and was completely absent in the whey as judged from Ca 19-9 assay. It could be effectively enriched by phenol-saline extraction from soluble milk proteins and further purified by gel filtration on Sephacryl S300 and Sephacryl S400. The active component with a bouyant density of 1.41 g/ml in isopycnic density gradient centrifugation (CsCl) shared common physico-chemical and chemical characteristics of mucus glycoproteins. Carbohydrates representing about 68% by weight were conjugated to protein by alkali-labile linkages, exclusively and were essentially free of D-mannose. Activities of Ca 125 and Ca 19-9 were both destroyed by treatment with periodate, mild alkali or neuraminidase suggesting the antigens are sialylated saccharides bound to protein by alkali-labile linkages. The fraction of monosialylated saccharide alditols isolated after reductive beta-elimination from the mucus glycoprotein was shown to inhibit monoclonal antibodies anti-(Ca 125) and anti-(Ca 19-9) in radioimmunoassay.

78 FR 30333 - Manufacturer of Controlled Substances; Notice of Registration; Siegfried (Usa), Llc.

Science.gov (United States)

2013-05-22

...; Notice of Registration; Siegfried (Usa), Llc. By Notice dated November 19, 2012, and published in the Federal Register on November 27, 2012, 77 FR 70825, Siegfried (USA), LLC., 33 Industrial Park Road... 21 U.S.C. 823(a) and determined that the registration of Siegfried (USA), LLC., to manufacture the...

78 FR 64020 - Manufacturer of Controlled Substances; Notice of Registration; Siegfried USA, LLC

Science.gov (United States)

2013-10-25

...; Notice of Registration; Siegfried USA, LLC By Notice dated May 22, 2013, and published in the Federal Register on May 30, 2013, 78 FR 32458, Siegfried USA, LLC., 33 Industrial Park Road, Pennsville, New Jersey... determined that the registration of Siegfried USA, LLC., to manufacture the listed basic class of controlled...

P1 Morgen: Konfliktløsning over skolemaden i USA

DEFF Research Database (Denmark)

2013-01-01

Valg af materiale/medie/form: Radio Valg af arbejdsform: Formidling Begrundelse for valg af materiale/medie/form/arbejdsform: Formidling af erfaring og forskning fra USA......Valg af materiale/medie/form: Radio Valg af arbejdsform: Formidling Begrundelse for valg af materiale/medie/form/arbejdsform: Formidling af erfaring og forskning fra USA...

Endise USA vastuluuraja naasmine / Priit Pullerits

Index Scriptorium Estoniae

Pullerits, Priit, 1965-

2008-01-01

USA poliitikateaduste professorist Christopher L. Kukest, kes käesoleval õppeaastal töötab Fulbright Scholar programmi stipendiaadina Tartu Ülikoolis. Lisa: CV. Kommenteerib Tartu Ülikooli riigiteaduste instituudi doktorant Mihkel Solvak

Euroliit palus USA-l sulgeda Guantanamo vangla / Kaarel Kaas, Toomas Sildam

Index Scriptorium Estoniae

Kaas, Kaarel, 1978-

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 22. juuni lk. 8. Euroopa Liidu ja USA tippkohtumisel Viinis oli arutluse all Guantanamo vangilaagri sulgemine, kõneldi Iraani tuumaprogrammist, maailmakaubandusest ning USA viisavabaduse kehtestamisest kõigile Euroopa Liidu liikmetele

Glu¹⁰⁶ in the Orai1 pore contributes to fast Ca²⁺-dependent inactivation and pH dependence of Ca²⁺ release-activated Ca²⁺ (CRAC) current.

Science.gov (United States)

Scrimgeour, Nathan R; Wilson, David P; Rychkov, Grigori Y

2012-01-15

FCDI (fast Ca²⁺-dependent inactivation) is a mechanism that limits Ca²⁺ entry through Ca²⁺ channels, including CRAC (Ca²⁺ release-activated Ca²⁺) channels. This phenomenon occurs when the Ca²⁺ concentration rises beyond a certain level in the vicinity of the intracellular mouth of the channel pore. In CRAC channels, several regions of the pore-forming protein Orai1, and STIM1 (stromal interaction molecule 1), the sarcoplasmic/endoplasmic reticulum Ca²⁺ sensor that communicates the Ca²⁺ load of the intracellular stores to Orai1, have been shown to regulate fast Ca²⁺-dependent inactivation. Although significant advances in unravelling the mechanisms of CRAC channel gating have occurred, the mechanisms regulating fast Ca²⁺-dependent inactivation in this channel are not well understood. We have identified that a pore mutation, E106D Orai1, changes the kinetics and voltage dependence of the ICRAC (CRAC current), and the selectivity of the Ca²⁺-binding site that regulates fast Ca²⁺-dependent inactivation, whereas the V102I and E190Q mutants when expressed at appropriate ratios with STIM1 have fast Ca²⁺-dependent inactivation similar to that of WT (wild-type) Orai1. Unexpectedly, the E106D mutation also changes the pH dependence of ICRAC. Unlike WT ICRAC, E106D-mediated current is not inhibited at low pH, but instead the block of Na⁺ permeation through the E106D Orai1 pore by Ca²⁺ is diminished. These results suggest that Glu¹⁰⁶ inside the CRAC channel pore is involved in co-ordinating the Ca²⁺-binding site that mediates fast Ca²⁺-dependent inactivation.

An economic evaluation of alternative biofuel deployment scenarios in the USA

Directory of Open Access Journals (Sweden)

Gbadebo Oladosu

2017-05-01

Full Text Available Energy market conditions have shifted dramatically since the USA renewable fuel standards (RFS1 in 2005; RFS2 in 2007 were enacted. The USA has transitioned from an increasing dependence on oil imports to abundant domestic oil production. In addition, increases in the use of ethanol, the main biofuel currently produced in the USA, is now limited by the blend wall constraint. Given this, the current study evaluates alternative biofuel deployment scenarios in the USA, accounting for changes in market conditions. The analysis is performed with a general equilibrium model that reflects the structure of the USA biofuel market as the transition to advanced biofuels begins. Results suggest that ethanol consumption would increase, albeit slowly, if current biofuel deployment rates of about 10% are maintained as persistently lower oil prices lead to a gradual increase in the consumption of liquid transportation fuels. Without the blend wall constraint, this study finds that the overall economic impact of a full implementation of the USA RFS2 policy is largely neutral before 2022. However, the economic impacts become slightly negative under the blend wall constraint since more expensive bio-hydrocarbons are needed to meet the RFS2 mandates. Results for a scenario with reduced advanced biofuel deployment based on current policy plans show near neutral economic impacts up to 2027. This scenario is also consistent with another scenario where the volume of bio-hydrocarbons deployed is reduced to adjust for its higher cost and energy content relative to deploying the mandated RFS2 advanced biofuel volumes as ethanol. The important role of technological change is demonstrated under pioneer and accelerated technology scenarios, with the latter leading to neutral or positive economic effects up to 2023 under most blend wall scenarios. All scenarios evaluated in this study are found to have positive long-term benefits for the USA economy.

USA terroriekspert süüdistab Bushi lootuste petmises / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2004-01-01

USA-s toimuvad erikomisjoni kuulamised 11. septembri 2001 terrorirünnakute asjus, kus tunnistusi andnud terrorivastast võitlust juhtinud Richard Clarke kinnitas, et president George W. Bushi valitsus ei pidanud terrorismivastast võitlust kõige tähtsamaks

The U.S.A. and the energy safety in East Asia

International Nuclear Information System (INIS)

Harmat, K.

2006-01-01

In the contribution under consideration the author reports on the impact of the United States of America (U.S.A.) in East Asia. The American policy in East Asia is based on two fundamental principles: providing, that no regional authority may provoke the position of the U.S.A., as well as protection of the access to regional markets for the American economy. The U.S.A. fulfill their protective function of their Asiatic partners by means of their maritime superiority with the pacific fleet. Strong-points and safety contracts with Japan and the Republic of Korea form the support of the presence of the U.S. American military. The According to energy security, the interests of the U.S.A. in East Asia are: (a) Secure supply of the national economies in East Asia; (b) Security of the maritime supply systems; (c) Stability and liberalization of the international oil markets; (d) Responsible handling of nuclear energy; (e) Environmental protection. Furthermore, the author describes the conflict potentials between the U.S.A. and the energy safety in East Asia as well as the long-term significance of the energy safety in East Asia

Fulltext PDF

Indian Academy of Sciences (India)

Srimath

Osamu Shimomura, Marine Biological Laboratory (MBL), Woods Hole, MA, USA. Boston University Medical School, Massachusetts, MA, USA. Martin Chalfie, Columbia University, New York, NY, USA. Roger Y Tsien, University of California, San Diego, CA, USA; Howard Hughes. Medical Institute. Physiology or Medicine.

Absolute Ca Isotopic Measurement Using an Improved Double Spike Technique

Directory of Open Access Journals (Sweden)

Jason Jiun-San Shen

2009-01-01

Full Text Available A new vector analytical method has been developed in order to obtain the true isotopic composition of the 42Ca-48Ca double spike. This is achieved by using two different sample-spike mixtures combined with the double spike and natural Ca data. Be cause the natural sample (two mixtures and the spike should all lie on a single mixing line, we are able to con strain the true isotopic composition of our double spike using this new approach. Once the isotopic composition of the Ca double spike is established, we are able to obtain the true Ca isotopic composition of the NIST Ca standard SRM915a, 40Ca/44Ca = 46.537 ± 2 (2sm, n = 55, 42Ca/44Ca = 0.31031 ± 1, 43Ca/44Ca = 0.06474 ± 1, and 48Ca/44Ca = 0.08956 ± 1. De spite an off set of 1.3% in 40Ca/44Ca between our result and the previously re ported value (Russell et al. 1978, our data indicate an off set of 1.89__in 40Ca/44Ca between SRM915a and seawater, entirely consistent with the published results.

International Semiconductor Laser Conference. Held in Boston, Massachusetts on August 29 - September 1, 1988

Science.gov (United States)

1988-11-01

gastronomically rewarding. Excellent restaurants serving seafood, "natural-foods’, and European and Asian dishes are everywhere. A baseball game at nearby...Laboratories, Holmdel, NJ, USA .......... 6-7 A:4 9:00 am DFB Lasers with a Crescent-Shaped Active Layer on a Corrugated p-type Substrate Y Ogawa, H. Horikawa...Berkeley, CA, USA ; W.M. Clark Jr., E.H. Stevens and MW Utlaut, Hughes Research Laboratories, Malibu, CA, USA .. 12-13 A:7 9:45 am Nanosecond Wavelength

Tendency to adhere to provider-recommended treatments and subsequent pain severity among individuals with cancer

OpenAIRE

Anthony Jerant; Peter Franks; Daniel J Tancredi; et al

2011-01-01

Anthony Jerant1, Peter Franks1, Daniel J Tancredi2, Naomi Saito3, Richard L Kravitz41Department of Family and Community Medicine, Center for Healthcare Policy and Research, University of California Davis School of Medicine, Sacramento, CA, USA; 2Department of Pediatrics, Center for Healthcare Policy and Research, University of California Davis School of Medicine, Sacramento, CA, USA; 3Center for Healthcare Policy and Research, University of California Davis School of Medicine, Sacramento, CA,...

Clinical value of preoperative serum CA 19-9 and CA 125 levels in predicting the resectability of hilar cholangiocarcinoma.

Science.gov (United States)

Hu, Hai-Jie; Mao, Hui; Tan, Yong-Qiong; Shrestha, Anuj; Ma, Wen-Jie; Yang, Qin; Wang, Jun-Ke; Cheng, Nan-Sheng; Li, Fu-Yu

2016-01-01

To examine the predictive value of tumor markers for evaluating tumor resectability in patients with hilar cholangiocarcinoma and to explore the prognostic effect of various preoperative factors on resectability in patients with potentially resectable tumors. Patients with potentially resectable tumors judged by radiologic examination were included. The receiver operating characteristic (ROC) analysis was conducted to evaluate serum carbohydrate antigenic determinant 19-9 (CA 19-9), carbohydrate antigen 125 (CA 125) and carcino embryonie antigen levels on tumor resectability. Univariate and multivariate logistic regression models were also conducted to analysis the correlation of preoperative factors with resectability. In patients with normal bilirubin levels, ROC curve analysis calculated the ideal CA 19-9 cut-off value of 203.96 U/ml in prediction of resectability, with a sensitivity of 83.7 %, specificity of 80 %, positive predictive value of 91.1 % and negative predictive value of 66.7 %. Meanwhile, the optimal cut-off value for CA 125 to predict resectability was 25.905 U/ml (sensitivity, 78.6 %; specificity, 67.5 %). In a multivariate logistic regression model, tumor size ≤3 cm (OR 4.149, 95 % CI 1.326-12.981, P = 0.015), preoperative CA 19-9 level ≤200 U/ml (OR 20.324, 95 % CI 6.509-63.467, P hilar cholangiocarcinoma. Preoperative CA 19-9 and CA 125 levels predict resectability in patients with radiological resectable hilar cholangiocarcinoma. Increased preoperative CA 19-9 levels and CA 125 levels are associated with poor resectability rate.

Die territorialen Grenzen der Human Rights Litigation in den USA / Michael Stürner

Index Scriptorium Estoniae

Stürner, Michael

2014-01-01

Kahju hüvitamisest rahvusvaheliste õigusnormide rikkumise puhul, territoriaalsetest piiridest inimõiguste alases kohtuvaidluses USA-s. Kohtuasjast Kiobel versus Royal Dutch Petroleum Co. Ameerika Ühendriikide kohtutesse saab esitada inimõiguste rikkumisega seotud hagisid ka USA kodakondsust mitteomavad inimesed

Ca{sup 2+}/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association

Energy Technology Data Exchange (ETDEWEB)

Ozaki, Hana [Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, 739-8521 (Japan); Katoh, Tsuyoshi [Department of Biochemistry, Asahikawa Medical University, Asahikawa, 078-8510 (Japan); Nakagawa, Ryoko; Ishihara, Yasuhiro [Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, 739-8521 (Japan); Sueyoshi, Noriyuki; Kameshita, Isamu [Department of Life Sciences, Faculty of Agriculture, Kagawa University, Kagawa, 761-0795 (Japan); Taniguchi, Takanobu [Department of Biochemistry, Asahikawa Medical University, Asahikawa, 078-8510 (Japan); Hirano, Tetsuo; Yamazaki, Takeshi [Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, 739-8521 (Japan); Ishida, Atsuhiko, E-mail: aishida@hiroshima-u.ac.jp [Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, 739-8521 (Japan)

2016-09-02

Ca{sup 2+}/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) is a Ser/Thr phosphatase that belongs to the PPM family. Growing evidence suggests that PPM phosphatases including CaMKP act as a complex with other proteins to regulate cellular functions. In this study, using the two-dimensional far-western blotting technique with digoxigenin-labeled CaMKP as a probe, in conjunction with peptide mass fingerprinting analysis, we identified neurofilament L (NFL) as a CaMKP-binding protein in a Triton-insoluble fraction of rat brain. We confirmed binding of fluorescein-labeled CaMKP (F-CaMKP) to NFL in solution by fluorescence polarization. The analysis showed that the dissociation constant of F-CaMKP for NFL is 73 ± 17 nM (n = 3). Co-immunoprecipitation assay using a cytosolic fraction of NGF-differentiated PC12 cells showed that endogenous CaMKP and NFL form a complex in cells. Furthermore, the effect of CaMKP on self-assembly of NFL was examined. Electron microscopy revealed that CaMKP markedly prevented NFL from forming large filamentous aggregates, suggesting that CaMKP-binding to NFL inhibits its filament association. These findings may provide new insights into a novel mechanism for regulating network formation of neurofilaments during neuronal differentiation. - Highlights: • NFL was identified as a CaMKP-binding protein in an insoluble fraction of rat brain. • CaMKP bound to NFL in solution with a K{sub d} value of 73 ± 17 nM. • A CaMKP-NFL complex was found in NGF-differentiated PC12 cells. • CaMKP-binding to NFL inhibited its filament association. • CaMKP may regulate network formation of neurofilaments in neurons.

"Riia ring, "luurepost ja tööjaotus USA esindustest Baltikumis 1920. aastatel / Eero Medijainen""

Index Scriptorium Estoniae

Medijainen, Eero, 1959-

2012-01-01

Diplomaatilisest taustast. USA esinduste rajamisest Baltikumi. Olukorrast USA saatkonnas 1922. aastal. USA sõjalisest vaatlejast "Balti provintsides" 1919-1922. Luurekeskusest ja Sergius Riisist. "Vene sektsiooni" formaliseeerumisest.

Determination of 40Ca and 48Ca matter densities by 600 MeV and 1 GeV proton elastic scattering

International Nuclear Information System (INIS)

Brissaud, I.; Campi, X.

1979-02-01

The 600MeV and 1GeV data of proton elastic scattering on 40 Ca and 48 Ca have been analyzed in the framework of the Glauber model. The matter distributions are extracted from the data in an approximately model-independent form based on a Fourier series expansion. A similar method is used to deduce directly the 48 Ca- 40 Ca neutron density difference

USA välispoliitiliste hoiakute muutumine XXI sajandi alguses / Aap Neljas

Index Scriptorium Estoniae

Neljas, Aap, 1967-

2003-01-01

USA poliitikas on olnud ilmne tendents jagada "rahulikes piirkondades" korrahoidmise koormat teiste suurriikidega ja säilitada vabad käed suuremate kriiside lahendamiseks, kus kaalul on otseselt USA rahvuslikud huvid (nt ligipääs naftale või juhtroll maailmas)

Marketing and Testosterone Treatment in the USA: A Systematic Review.

Science.gov (United States)

Bandari, Jathin; Ayyash, Omar M; Emery, Sherry L; Wessel, Charles B; Davies, Benjamin J

2017-10-01

Testosterone replacement therapy (TRT) is currently approved by the Food and Drug Administration only for classic hypogonadism, although off-label indications have resulted in a dramatic expansion in prescriptions in the USA. Marketing may significantly affect prescriber behavior. To systematically review all available evidence on marketing and TRT in the USA. PubMed, Embase, and Scopus were searched up to July 2017 for all relevant publications reporting on assessments of the TRT market size, economic costs associated with hypogonadism, trends in TRT prescriptions, drug discontinuation rates, and advertising and sales efforts in the USA. Twenty retrospective studies were included in the final analysis. The market size for hypogonadism constitutes 5.6-76.8% of men in the USA, with the lower end of the range representing the strictest criteria for diagnosis. Men with a diagnosis of hypogonadism consume $14 118 in direct and indirect costs to the payer. Over the last 2 decades, TRT prescriptions have increased between 1.8- and 4-fold. After 1 yr, 80-85% of men discontinue TRT. There is an association between direct-to-consumer advertising and testosterone testing, TRT prescriptions, and TRT without testosterone testing. There is a high prevalence of misinformation on Internet advertising. Off-label indications have driven the dramatic expansion of TRT prescriptions over the last 2 decades. Direct-to-consumer advertising poses a unique challenge in the USA. Overtreatment can be avoided by applying strict diagnostic criteria for hypogonadism, which limits the addressable market for TRT. In this report, we reviewed the relationship between marketing and testosterone therapy in the USA. We found that many patients are prescribed testosterone without an appropriate diagnosis of hypogonadism, which may be related to the marketing efforts for off-label prescribing. Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.

USA jälgib Valgevenet valimiste eel pingsalt / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 9. märts lk. 10. USA pöörab suurt tähelepanu 19. märtsil Valgevenes toimuvatele presidendivalimistele. USA välisministeeriumi Euroopa ja Euraasia osakonna asejuhataja David Krameri sõnul tuleb Valgevene võimudel tagada presidendivalimiste ausus ja kandidaatide turvalisus. Lisa. Valimised

Effects of soil calcium and aluminum on the physiology of balsam fir and red spruce saplings in northern New England

Science.gov (United States)

Richard L. Boyce; Paul G. Schaberg; Gary J. Hawley; Joshua M. Halman; Paula F. Murakami

2013-01-01

We examined the influence of calcium (Ca) and aluminum (Al) nutrition on the foliar physiology of red spruce (Picea rubens Sarg.) and balsam fir [Abies balsamea (L.) Mill.] in northern New England, USA. At the Hubbard Brook Experimental Forest (NH, USA), spruce and fir saplings were sampled from control, Al-, and Ca-supplemented...

Performance Characteristics of CA 19-9 Radioimmunoassay and Clinical Significance of Serum CA 19-9 Assay in Patients with Malignancy

International Nuclear Information System (INIS)

Kim, Sang Eun; Shong, Young Kee; Cho, Bo Youn; Kim, Noe Kyeong; Koh, Chang Soon; Lee, Mun Ho; Hong, Seong Woon; Hong, Kee Suk

1985-01-01

To evaluate the performance characteristics of CA 19-9 radioimmunoassay and the clinical significance of serum CA 19-9 assay in patients with malignancy, serum. CA 19-9 levels were measured by radioimmunoassay using monoclonal antibody in 135 normal controls, 81 patients with various untreated malignancy, 9 patients of postoperative colon cancer without recurrence and 20 patients with benign gastrointestinal diseases, who visited Seoul National University Hospital from June, 1984 to March, 1985. The results were as follows; 1) The CA 19-9 radioimmunoassay was simple to perform and can be completed in one work day. And the between-assay reproducibility and the assay recovery were both excellent. 2) The mean serum CA 19-9 level in 135 normal controls was 8.4±4.2 U/mL. Normal upper limit of serum CA 19-9 was defined as 21.0 U/mL. 4 out of 135 (3.0%) normal controls showed elevated CA 19-9 levels above the normal upper limit. 3) One out of 20 (5.0%) patients with benign gastrointestinal diseases showed elevated serum CA 19-9 level above the normal upper limit. 4) In 81 patients with various untreated malignancy, 41 patients (50.6%) showed elevated serum CA 19-9 levels. 66.7% of 18 patients with colorectal cancer, 100% of 2 patients with pancreatic cancer, 100% of 3 patients with common bile duct cancer, 47.1% of 17 patients with stomach cancer, 28.6% of 28 patients with hepatoma and 60.0% of 5 gastrointestinal tract cancers showed elevated serum CA 19-9 levels. 5) The sensitivities of serum CA 19-9 related to respectability in colorectal and stomach cancer were 33.3% in resectable colorectal cancer, 83.3% in unresectable colorectal cancer, 41.7% in resectable stomach cancer, 60.0% in unresectable stomach cancer respectively. 6) The sensitivity of serum CA 19-9 in 9 patients of postoperative colorectal cancer without recurrence were 33.3% and significantly decreased compared with that of untreated colorectal cancer, 66.7% (p<0.05). 7) In Patients with colorectal cancer

Ameerika suursaadik Aldona Sofia Wos : toon kättpidi USA suurfirmad Eestisse / Aldona Zofia Wos ; interv. Airi Ilisson

Index Scriptorium Estoniae

Wos, Aldona Zofia

2005-01-01

USA suursaadik Eestis vastab küsimustele, mis on seotud Londonis USA riigidepartemangu korraldatud konverentsiga, kus Balti riikide juhid rääkisid USA ettevõtete esindajatele, miks tuleks investeerida Balti riikidesse. USA tehtud investeeringutest Eestisse, Eesti ettevõtjate võimalustest USA-s. Lisa: Tõhus rahapüüdja

Dyslexia Laws in the USA

Science.gov (United States)

Youman, Martha; Mather, Nancy

2013-01-01

Throughout the various states of the USA, the appropriate identification of dyslexia and the timely provision of interventions are characterized by variability and inconsistency. Several states have recognized the existence of this disorder and the well-established need for services. These states have taken proactive steps to implement laws and…

Hydriding and dehydriding properties of CaSi

International Nuclear Information System (INIS)

Aoki, Masakazu; Ohba, Nobuko; Noritake, Tatsuo; Towata, Shin-ichi

2005-01-01

The hydriding and dehydriding properties of CaSi were investigated both theoretically and experimentally. First-principles calculations suggested that CaSiH n is thermodynamically stable. Experimentally, the p -c isotherms clearly demonstrated plateau pressures in a temperature range of 473-573 K and the maximum hydrogen content was 1.9 weight % (wt.%) under a hydrogen pressure of 9 MPa at 473 K. The structure of CaSiH n is different from those of ZrNi hydrides, although CaSi has the CrB-type structure as well as ZrNi

Novel method of generation of Ca(HCO32 and CaCO3 aerosols and first determination of hygroscopic and cloud condensation nuclei activation properties

Directory of Open Access Journals (Sweden)

A. Trimborn

2010-09-01

Full Text Available Atmospheric mineral aerosols contain CaCO3 as a reactive component. A novel method to produce CaCO3 aerosol was developed by spraying Ca(HCO32 solution, which was generated from a CaCO3 suspension and CO2. By aerosol mass spectrometry the freshly sprayed and dried aerosol was characterized to consist of pure Ca(HCO32 which under annealing in a tube furnace transformed into CaCO3. Transmission Electron Microscopy demonstrated that the particles produced were spherical. The method was able to generate aerosol of sufficient concentration and proper size for the study of physiochemical properties and investigations of heterogeneous reactions of mineral aerosol. The dried Ca(HCO32 particles were somewhat more hygroscopic than CaCO3 particles. However, during humidification a restructuring took place and ∼2/3 of the Ca(HCO32 was transformed to CaCO3. The mixed Ca(HCO32/CaCO3(s particles were insoluble with a growth factor of 1.03 at 95% (hygroscopicity parameter κ=0.011±0.007 relative humidity. This compares to a corresponding growth factor of 1.01 for CaCO3(s (κ=0.0016±0.0004. Mass spectrometric composition analysis, restructuring, and insolubility of the mixed particles suggested that solid Ca(HCO32(s was observed. This would be in contrast to the current belief that Ca(HCO32(s is thermodynamically instable. The CCN activity of Ca(HCO32(s aerosol (κ≈0.15 is remarkably higher than that of CaCO3 aerosol (κ=0.0019±0.0007 and less than that of Ca(NO32. The noticeable but limited solubility of Ca(HCO32 of ≈0.01 mol/l explains limited hygroscopic growth and good CCN activity. Experiments in the Large Jülich Aerosol Chamber indicated that Ca(HCO32(s could exist for several hours under dry atmospheric conditions. However, it was likely buried in a protective layer of CaCO3(s. We conclude that Ca(HCO32 may be formed in the atmosphere in cloud droplets of activated mineral dust by reaction of CaCO3 with CO2 and H2O. The presence of Ca(HCO32 and

USA-Hiina luurelennukitüli ähvardab suureks paisuda / Erkki Bahovski

Index Scriptorium Estoniae

Bahovski, Erkki, 1970-

2001-01-01

USA-Hiina tüli luurelennuki pärast võib kahjustada Hiina pääsu WTO-sse. Analüütikute arvates näitavad mitmed hiljutised intsidendid USA huvi Hiina sõjasaladuste vastu. Vt. samas "Eesti rannikut seirab Vene lennuk"

Cardiac microvascular endothelial cells express a functional Ca+ -sensing receptor.

Science.gov (United States)

Berra Romani, Roberto; Raqeeb, Abdul; Laforenza, Umberto; Scaffino, Manuela Federica; Moccia, Francesco; Avelino-Cruz, Josè Everardo; Oldani, Amanda; Coltrini, Daniela; Milesi, Veronica; Taglietti, Vanni; Tanzi, Franco

2009-01-01

The mechanism whereby extracellular Ca(2+) exerts the endothelium-dependent control of vascular tone is still unclear. In this study, we assessed whether cardiac microvascular endothelial cells (CMEC) express a functional extracellular Ca(2+)-sensing receptor (CaSR) using a variety of techniques. CaSR mRNA was detected using RT-PCR, and CaSR protein was identified by immunocytochemical analysis. In order to assess the functionality of the receptor, CMEC were loaded with the Ca(2+)-sensitive fluorochrome, Fura-2/AM. A number of CaSR agonists, such as spermine, Gd(3+), La(3+) and neomycin, elicited a heterogeneous intracellular Ca(2+) signal, which was abolished by disruption of inositol 1,4,5-trisphosphate (InsP(3)) signaling and by depletion of intracellular stores with cyclopiazonic acid. The inhibition of the Na(+)/Ca(2+) exchanger upon substitution of extracellular Na(+) unmasked the Ca(2+) signal triggered by an increase in extracellular Ca(2+) levels. Finally, aromatic amino acids, which function as allosteric activators of CaSR, potentiated the Ca(2+) response to the CaSR agonist La(3+). These data provide evidence that CMEC express CaSR, which is able to respond to physiological agonists by mobilizing Ca(2+) from intracellular InsP(3)-sensitive stores. Copyright 2008 S. Karger AG, Basel.

USA soovib relvatarnete abil vähendada Iraani mõjuvõimu / Jürgen Tamme

Index Scriptorium Estoniae

Tamme, Jürgen

2007-01-01

Ilmunud ka: Postimees : na russkom jazõke, 31. juuli 2007, lk. 5. USA president George W. Bushi administratsioon soovib Kongressi heakskiitu plaanile, mis näeb ette Pärsia lahe piirkonnas asuvate USA liitlaste rahaliste toetuste suurendamist ja neile relvastuse saatmist. Lisa: USA tarned

Recent developments: USA

International Nuclear Information System (INIS)

Anon.

1990-01-01

The development of a National Energy Stategy (NES) for the USA is discussed. On July 26, 1989 President Bush directed of the Secretary of Energy to submit to the President a NES based on the following guidelines: to develop a NES through the year 2030 that could be implemented as son as possible, rather than waiting until the next energy crisis; to formulate the program so that it will create public consensus; build upon market reliance, rather than coercion; and to take a can do approach, capitalizing on US scientific knowledge and common abuse

Ilves : usk vabadusse on Eesti ja USA liitlasteks sõlminud / Lauri Birkan

Index Scriptorium Estoniae

Birkan, Lauri

2007-01-01

Washingtonis toimunud ligi kahe tunni pikkusel kohtumisel arutlesid USA president George W. Bush ja president Toomas Hendrik Ilves arengute üle Afganistanis ja Iraagis, rääkisid küberjulgeolekust, viisavabadusest, USA ja Venemaa ning Euroopa Liidu ja Venemaa suhetest. T.H. Ilves kutsus USAd osalema NATO küberkaitsekeskuse (Center of Excellence) loomisel Tallinnas. Kohtumise juures viibis ka USA asepresident Dick Cheney. Vabariigi President töövisiidil Ameerika Ühendriikides 25.-26.06.2007

Enamik Mõtteloo Sihtkapitali rahast kasvab USA aktsiates / Mart Trummal ; interv. Anne Oja

Index Scriptorium Estoniae

Trummal, Mart

2006-01-01

Intervjuu Eesti Mõtteloo Sihtkapitali juhi Mart Trummaliga. Tabel: Mõtteloo Sihtkapitali vara on USA-s noteeritud indeksifondides; Investeeringud Eesti aktsiatesse. Diagramm: Finantsinvesteeringute maht. Vt. samas: Anne Oja. Dividendisaajate esirinnas. Kommenteerib Annika Matson

The estimation of daily intake and organ content of Ca, Cs, I, K, Sr, Th and U in Indian population

International Nuclear Information System (INIS)

Jaiswal, D.D.; Dang, H.S.; Pullat, V.R.; Parameswaran, M.

2000-01-01

The analytical methods involving both instrumental and radiochemical neutron activation analysis (INAA and RNAA) were standardised and applied for the determination of the elements: Ca, Cs, I, K, Sr, Th and U in various kinds of biological samples. The results of the analysis of six Standard Reference Materials (NIST-USA) received from IAEA, namely, Bone Meal, Oyester Tissue, Muscle Powder, Total Diet I and II and Pine Needles are reported. The results obtained are in good agreement with the average values of those reported from six laboratories. The results of the analysis of skeletal muscle samples for the trace elements Cs and K, individual food components which form major essential components of Indian diet and a few cooked total diets are also reported for the above named seven elements. (author)

Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability.

Science.gov (United States)

Neef, Stefan; Mann, Christian; Zwenger, Anne; Dybkova, Nataliya; Maier, Lars S

2017-07-01

Sarcoplasmic reticulum (SR) Ca 2+ leak induced by Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is centrally involved in atrial and ventricular arrhythmogenesis as well as heart failure remodeling. Consequently, treating SR Ca 2+ leak has been proposed as a novel therapeutic paradigm, but compounds for use in humans are lacking. SMP-114 ("Rimacalib") is a novel, orally available CaMKII inhibitor developed for human use that has already entered clinical phase II trials to treat rheumatoid arthritis. We speculated that SMP-114 might also be useful to treat cardiac SR Ca 2+ leak. SMP-114 significantly reduces SR Ca 2+ leak (as assessed by Ca 2+ sparks) in human atrial (0.72 ± 0.33 sparks/100 µm/s vs. control 3.02 ± 0.91 sparks/100 µm/s) and failing left ventricular (0.78 ± 0.23 vs. 1.69 ± 0.27 sparks/100 µm/s) as well as in murine ventricular cardiomyocytes (0.30 ± 0.07 vs. 1.50 ± 0.28 sparks/100 µm/s). Associated with lower SR Ca 2+ leak, we found that SMP-114 suppressed the occurrence of spontaneous arrhythmogenic spontaneous Ca 2+ release (0.356 ± 0.109 vs. 0.927 ± 0.216 events per 30 s stimulation cessation). In consequence, post-rest potentiation of Ca 2+ -transient amplitude (measured using Fura-2) during the 30 s pause was improved by SMP-114 (52 ± 5 vs. 37 ± 4%). Noteworthy, SMP-114 has these beneficial effects without negatively impairing global excitation-contraction coupling: neither systolic Ca 2+ release nor single cell contractility was compromised, and also SR Ca 2+ reuptake, in line with resulting cardiomyocyte relaxation, was not impaired by SMP-114 in our assays. SMP-114 demonstrated potential to treat SR Ca 2+ leak and consequently proarrhythmogenic events in rodent as well as in human atrial cardiomyocytes and cardiomyocytes from patients with heart failure. Further research is necessary towards clinical use in cardiac disease.

Comparative epidemiology of Clostridium difficile infection: England and the USA.

Science.gov (United States)

King, Alice; Mullish, Benjamin H; Williams, Horace R T; Aylin, Paul

2017-10-01

To examine whether there is an epidemiological difference between Clostridium difficile infection (CDI) inpatient populations in England and the United States. A cross-sectional study. National administrative inpatient discharge data from England (Hospital Episode Statistics) and the USA (National Inpatient Sample) in 2012. De-identifiable non-obstetric inpatient discharges from the national datasets were used to estimate national CDI incidence in the United States and England using ICD9-CM(008.45) and ICD10(A04.7) respectively. The rate of CDI was calculated per 100 000 population using national population estimates. Rate per 100 000 inpatient discharges was also calculated separated by primary and secondary diagnosis of CDI. Age, sex and Elixhauser comorbidities profiles were examined. The USA had a higher rate of CDI compared to England: 115.1/100 000 vs. 19.3/100 000 population (P USA (OR 1.20 95% CI [1.18,1.22] P USA compared to England apart from dementia, which was greater in England (9.63% vs. 1.25%, P USA was much higher than in England. Age and comorbidity profiles also differed between CDI patients in both countries. The reasons for this are likely multi-factorial but may reflect national infection control policy. © The Author 2017. Published by Oxford University Press in association with the International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Ca(AlH4)2, CaAlH5, and CaH2+6LiBH4 : Calculated dehydrogenation enthalpy, including zero point energy, and the structure of the phonon spectra

NARCIS (Netherlands)

Marashdeh, A.; Frankcombe, T.J.

2008-01-01

The dehydrogenation enthalpies of Ca(AlH4)2, CaAlH5, and CaH2+6LiBH4 have been calculated using density functional theory calculations at the generalized gradient approximation level. Harmonic phonon zero point energy (ZPE) corrections have been included using Parlinski’s direct method. The

Interference of apex locator, pulp tester and diathermy on pacemaker function

OpenAIRE

Narayanan Sriman; V Prabhakar; J S Bhuvaneswaran; N Subha

2015-01-01

Aim: The purpose of this study was to evaluate the effects of three electronic apex locators (EAL), electric pulp tester (EPT) and diathermy on pacemaker function in vitro. Materials and Methods: Three EALs: Root ZX (J. Morita Co., Tustin, CA, U.S.A.), Propex (Dentsply), Mini Apex locator (SybronEndo, Anaheim, CA, USA), EPT (Parkell pulp vitality tester Farmingdale, NY, USA) and Diathermy (Neomed 250 B) were tested for any interference with one pacemaker (A medtronic kappa KVDD901-serial ...

Basic and clinical evaluation of CA 130 RIA kit (D-7111) using two newly developed monoclonal antibodies. Comparison with CA 125 kit

Energy Technology Data Exchange (ETDEWEB)

Saga, Tsuneo; Endo, Keigo; Nakajima, Tetsuo and others

1988-10-01

The CA 130 RIA kit was developed with the use of two monoclonal antibodies, 130 - 22 and 145 - 9. Laboratory performance was satisfactory for precision, reproducibility, recovery, and dilution. Measurement values with CA 130 kit were almost consistent with those with CA 125 kit. Favorable standard curves were attained with smaller concentrations and shorter incubation time of CA 130 kit than those with CA 125 kit. There was less prozone phenomenon. When defining a cut-off serum level of CA 130 as 35 U/ml, false-positive rate was 0 % for healthy men and 4 % for healthy women, suggesting the involvement of menstrual cycle. Positive rate for CA 130 was 65 % for malignant ovarian tumor, 48 % for lung cancer, and 47 % for endometriosis. (Namekawa, K.).

Break-up of Ca-montmorillonite particles by Na-montmorillonite

International Nuclear Information System (INIS)

Hedstroem, Magnus; Birgersson, Martin

2012-01-01

Document available in extended abstract form only. In the Swedish KBS-3 concept for a geological deep storage of spent nuclear fuel, bentonite of high montmorillonite content is proposed to serve as a buffer surrounding copper canisters containing the spent fuel. Montmorillonite has an exceptional affinity for water which results in the build-up of a swelling pressure when bentonite is placed in a confined volume. However, there is a concern that during and after a glaciation, meltwater of low ionic strength may cause the bentonite to swell extensively into fractures and turn into a sol that could be transported away by the seeping water. It is thus warranted to understand the behaviour of montmorillonite at aqueous condition of low ionic strength. Turbidity measurements were used to a large extent in previous work to follow the free swelling or settling process of montmorillonite in various aqueous solutions and thereby give information regarding sol formation. From theory we know that turbidity of a suspension is proportional to the particle concentration. However turbidity is also proportional to V p 2 where V p is the volume of the scattering particle. Thus the fact that turbidity of a Ca-montmorillonite suspension is higher than the turbidity of a Na- montmorillonite suspension of the same clay concentration indicates that Na-montmorillonite separate into smaller particles than Ca-montmorillonite. In this work we make use this size dependence to quantify the difference between Wyoming, Milos and Kutch montmorillonite in particular with respect to how mixed Ca/Na montmorillonite systems behave. Some Ca/Mg, Mg/Na and Na/K systems are also included for comparison. Figure 1 shows the final (stabilized) turbidity response of mixed Wy-Ca/Na montmorillonite as a function of the fraction of Ca 2+ in the clay. Starting material are suspensions of homo-ionic Wy-Ca and Wy-Na montmorillonite at a concentration of 1 g/l. The turbidity of the suspensions of the homo

Sustained increase of spontaneous input and spike transfer in the CA3-CA1 pathway following long term potentiation in vivo

Directory of Open Access Journals (Sweden)

Oscar eHerreras

2012-10-01

Full Text Available Long term potentiation (LTP is commonly used to study synaptic plasticity but the associated changes in the spontaneous activity of individual neurons or the computational properties of neural networks in vivo remain largely unclear. The multisynaptic origin of spontaneous spikes makes difficult estimating the impact of a particular potentiated input. Accordingly, we adopted an approach that isolates pathway-specific postsynaptic activity from raw local field potentials (LFPs in the rat hippocampus in order to study the effects of LTP on ongoing spike transfer between cell pairs in the CA3-CA1 pathway. CA1 Schaffer-specific LFPs elicited by spontaneous clustered firing of CA3 pyramidal cells involved a regular succession of elementary micro-field-EPSPs (gamma-frequency that fired spikes in CA1 units. LTP increased the amplitude but not the frequency of these ongoing excitatory quanta. Also, the proportion of Schaffer-driven spikes in both CA1 pyramidal cells and interneurons increased in a cell-specific manner only in previously connected CA3-CA1 cell pairs, i.e., when the CA3 pyramidal cell had shown pre-LTP significant correlation with firing of a CA1 unit and potentiated spike-triggered average of Schaffer LFPs following LTP. Moreover, LTP produced subtle reorganization of presynaptic CA3 cell assemblies. These findings show effective enhancement of pathway specific ongoing activity which leads to increased spike transfer in potentiated segments of a network. These indicate that plastic phenomena induced by external protocols may intensify spontaneous information flow across specific channels as proposed in transsynaptic propagation of plasticity and synfire chain hypotheses that may be the substrate for different types of memory involving multiple brain structures.

The hippocampal CA2 ensemble is sensitive to contextual change.

Science.gov (United States)

Wintzer, Marie E; Boehringer, Roman; Polygalov, Denis; McHugh, Thomas J

2014-02-19

Contextual learning involves associating cues with an environment and relating them to past experience. Previous data indicate functional specialization within the hippocampal circuit: the dentate gyrus (DG) is crucial for discriminating similar contexts, whereas CA3 is required for associative encoding and recall. Here, we used Arc/H1a catFISH imaging to address the contribution of the largely overlooked CA2 region to contextual learning by comparing ensemble codes across CA3, CA2, and CA1 in mice exposed to familiar, altered, and novel contexts. Further, to manipulate the quality of information arriving in CA2 we used two hippocampal mutant mouse lines, CA3-NR1 KOs and DG-NR1 KOs, that result in hippocampal CA3 neuronal activity that is uncoupled from the animal's sensory environment. Our data reveal largely coherent responses across the CA axis in control mice in purely novel or familiar contexts; however, in the mutant mice subject to these protocols the CA2 response becomes uncoupled from CA1 and CA3. Moreover, we show in wild-type mice that the CA2 ensemble is more sensitive than CA1 and CA3 to small changes in overall context. Our data suggest that CA2 may be tuned to remap in response to any conflict between stored and current experience.

Study on the diagnostic value of determination of changes of serum CA125 and CA19-9 levels in patients with endometriosis

International Nuclear Information System (INIS)

Liu Aimin

2008-01-01

Objective: To explore the diagnostic value of determination of changes of serum CA125 and CA19-9 levels in patients with endometriosis. Methods: Serum CA125 and CA19-9 levels were determined with RIA in 45 patients with endometriosis and 40 controls. Results: Serum levels of CA125 and CA19-9 in patients with endometriosis (89.63 ± 30.16u/ml and 95.62±43.67u/ml respectively) were significantly higher than those (16.26±6.37u/ml and 20.26±8.25u/ml respectively) in controls (P<0. 001). Sensitivity of CA125 for diagnosis of endometriosis was 77.78% and that of CA19-9 was 62.22%, while the specificity was 92.50% and 90.00% respectively. If we only took the patients with both markers elevated as being diagnostically positive, the sensitivity would naturally be lower (57.78%) but the specificity would be 100%. Levels of the markers were significantly higher in stage III, IV patients than those in patients with stage I, II disease (P<0.01). Conclusion: Combined determination of serum CA125 and CA19-9 levels were of highly specific diagnostic value in patients with endometriosis. (authors)

Control theory-based regulation of hippocampal CA1 nonlinear dynamics.

Science.gov (United States)

Hsiao, Min-Chi; Song, Dong; Berger, Theodore W

2008-01-01

We are developing a biomimetic electronic neural prosthesis to replace regions of the hippocampal brain area that have been damaged by disease or insult. Our previous study has shown that the VLSI implementation of a CA3 nonlinear dynamic model can functionally replace the CA3 subregion of the hippocampal slice. As a result, the propagation of temporal patterns of activity from DG-->VLSI-->CA1 reproduces the activity observed experimentally in the biological DG-->CA3-->CA1 circuit. In this project, we incorporate an open-loop controller to optimize the output (CA1) response. Specifically, we seek to optimize the stimulation signal to CA1 using a predictive dentate gyrus (DG)-CA1 nonlinear model (i.e., DG-CA1 trajectory model) and a CA1 input-output model (i.e., CA1 plant model), such that the ultimate CA1 response (i.e., desired output) can be first predicted by the DG-CA1 trajectory model and then transformed to the desired stimulation through the inversed CA1 plant model. Lastly, the desired CA1 output is evoked by the estimated optimal stimulation. This study will be the first stage of formulating an integrated modeling-control strategy for the hippocampal neural prosthetic system.

High-pressure synthesis and structural, physical properties of CaIr1-xPtxO3 and CaIr1-xRhxO3

Science.gov (United States)

Hirai, S.; Bromiley, G. D.; Klemme, S.; Irifune, T.; Ohfuji, H.; Attfield, P.; Nishiyama, N.

2010-12-01

Since the discovery of the perovskite to post-perovskite transition in MgSiO3 in a laser-heated DAC, wide attention has been focussed on the post-perovskite phase of MgSiO3. This is because the post-perovskite phase is likely to play a key role in Earth’s lowermost mantle, and because the perovskite to post-perovskite transition can explain many features of the D” seismic discontinuity. While it is meaningful to conduct further studies of MgSiO3, the post-perovskite phase of MgSiO3 cannot be quenched to ambient pressure/temperature conditions. Thus, further studies must be conducted using analogue compounds of MgSiO3 post-perovskite, which are quenchable to ambient pressure/temperature conditions. The post-perovskite phase of MgSiO3 crystallizes in a layered structure with CaIrO3-structure. Therefore, it is useful to investigate compounds with CaIrO3-structure. There are only four quenchable oxides with CaIrO3-structure reported to date: CaIrO3, CaPtO3, CaRhO3 and CaRuO3. CaIrO3 can be synthesized at ambient pressure, whilst the other three oxides can only be obtained at high pressure/temperature conditions using a multi-anvil apparatus. Further studies on these materials have revealed structural phase transitions at high P-T and a metal-insulator transition by hole doping. In the case of CaIrO3, The post-perovskite phase of CaIrO3 synthesized at 2GPa, 1373K transforms into a perovskite phase at 2GPa, 1673K. In other words, the perovskite phase can be synthesized at temperatures higher than those needed for synthesizing the post-perovskite phase. This is also the case for CaRhO3 (6GPa, 1873K) and CaRuO3 (23GPa, 1343K), while CaPtO3 remained post-perovskite at higher temperatures. We have succeeded in synthesizing solid solutions between CaIrO3, CaPtO3 and CaRhO3. We have found the systematic change in structural and physical properties of post-perovskite oxides, with composition and P-T, which broadens the future opportunity for studying post-perovskite systems