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Sample records for lee harvard jane

  1. Tokyo Jane

    DEFF Research Database (Denmark)

    Austin, Robert D.; Minbaeva, Dana; Schafer, Simon

    2014-01-01

    Tokyo Jane is an accessible fashion jewelry company that makes and markets its products as “luxury for less” by designing, importing and selling fashion jewelry pieces that look luxurious but cost only a fraction of the high-priced items that inspired them. Finished products are air-shipped to co......Tokyo Jane is an accessible fashion jewelry company that makes and markets its products as “luxury for less” by designing, importing and selling fashion jewelry pieces that look luxurious but cost only a fraction of the high-priced items that inspired them. Finished products are air......-shipped to company headquarters in Copenhagen, Denmark from factories in China, stocked in the head office and delivered to 400 retail partners —small fashion boutiques, big department stores and online shops — who then sell to consumers in Europe, Scandinavia, the United Kingdom and Canada. The two partners who...... founded the firm in 2005 are facing several problems: the brand definition is not well enough developed to support the next stage in the firm’s growth, certain challenges have outstripped available human resources — they have only three permanent employees and a revolving number of interns...

  2. Tokyo Jane

    DEFF Research Database (Denmark)

    Austin, Robert D.; Minbaeva, Dana; Schafer, Simon

    2014-01-01

    Tokyo Jane is an accessible fashion jewelry company that makes and markets its products as “luxury for less” by designing, importing and selling fashion jewelry pieces that look luxurious but cost only a fraction of the high-priced items that inspired them. Finished products are air......-shipped to company headquarters in Copenhagen, Denmark from factories in China, stocked in the head office and delivered to 400 retail partners —small fashion boutiques, big department stores and online shops — who then sell to consumers in Europe, Scandinavia, the United Kingdom and Canada. The two partners who...... — and distribution operations and management need to be rethought as the firm rapidly increases the scale of its operations. Things come to a head in April 2013, when they are confronted by an important customer about quality issues with their products. How can they not only save their company but continue to grow?...

  3. What Jane Saw

    Directory of Open Access Journals (Sweden)

    Kate Singer

    2013-11-01

    Full Text Available Review of Professor Janine Barchas' "What Jane Saw?" a website that reconstructs Joshua Reynolds's 1813 retrospective art exhibit, which Jane Austen attended, with particular attention to the Regency social and cultural history depicted in Austen's novels.

  4. Harvard Days.

    Science.gov (United States)

    Skinner, B. F.

    1979-01-01

    Excerpted from the second volume of his three-part autobiography, this essay describes B. F. Skinner's first year as a graduate student at Harvard University. Although he focuses on his study of psychology, particularly behaviorism, Skinner also discusses his interest in physiology. (JMD)

  5. Harvard's Historic Choice

    Science.gov (United States)

    Wilson, Robin

    2007-01-01

    In this article, the author profiles Drew Gilpin Faust, a career academic who has risen to the top job at Harvard University and has been named president of Harvard after six years as leader of its small Radcliffe Institute. Ms. Faust, who is 59, grew up in the Shenandoah Valley of Virginia, raised by a father who bred Thoroughbred horses and a…

  6. Conversations with Miss Jane

    Directory of Open Access Journals (Sweden)

    Geneviève Fabre

    2006-05-01

    Full Text Available Considering the wide range of conversations in the autobiography, this essay will attempt to appraise the importance of these verbal exchanges in relation to the overall narrative structure of the book and to the prevalent oral tradition in Louisiana culture, as both an individual and communal expression. The variety of circumstances, the setting and staging, the interlocutors , and the complex intersection of time and place, of stories and History, will be examined; in these conversations with Miss Jane many actors participate, from  the interviewer-narrator, to most characters; even the reader becomes involved.Speaking, hearing, listening, keeping silent is an elaborate ritual that performs many functions; besides conveying news or rumors, it imparts information on the times and on the life of a “representative” woman whose existence - spanning a whole century- is both singular and emblematic. Most importantly this essay will analyse the resonance of an eventful and often dramatic era on her sensibility and conversely show how her evolving sensibility informs that history and draws attention to aspects that might have passed unnoticed or be forever silenced. Jane’s desire for liberty and justice is often challenged as she faces the possibilities of life or death.Conversations build up a complex, often contradictory, but compelling portrait: torn between silence and vehemence, between memories and the urge to meet the future, Jane summons body and mind to find her way through the maze of a fast changing world; self-willed and obstinate she claims her right to speak, to express with wit and wisdom her firm belief in the word, in the ability to express deep seated convictions and faith and a whole array of feelings and emotions.

  7. Referencing handbook: Harvard

    OpenAIRE

    Elkin, Judith; Ortega, Marishona; Williams, Helen

    2016-01-01

    University of Lincoln approved guide to Harvard referencing. Providing guidelines on how to reference 75 sources of information. The second edition includes extended guidance on how to reference, all new examples, additional annotated diagrams and an index to help you locate sources.

  8. Peter & Jane: A Program Showcase

    Science.gov (United States)

    Kalinowski, Michael

    2008-01-01

    This article features the early childhood programs at Peter & Jane Kindergarten located in Petaling Java, Malaysia. The primary purpose of the programs is to lay a strong foundation for a lifelong love of learning in each child. According to principal Patricia Teh, the activities are funded by parent fees and serve children two to six years of…

  9. Internationalization at Harvard

    Directory of Open Access Journals (Sweden)

    Ned Strong

    2013-06-01

    Full Text Available The aim of this essay is to describe internationalization at Harvard University. Founded by European colonists in 17th century New England, Harvard has historic international roots. By the mid 1900’s it had become an international powerhouse attracting top students, academics and scientists from around the world. Yet, the University is international almost by default as it has reacted to world affairs. Looking toward the future, President Drew Faust has outlined a strategy to become “intentionally global”. One model, begun ten years ago, serves as an example for the future. In 2002 the University established its first overseas office designed to represent the entire institution. The theory was that a modest local infrastructure would encourage students and faculty to expand international collaborations and make a difference in the region benefiting from this presence. The results have been highly successful. The Regional Office in Santiago Chile, representing Argentina, Bolivia, Chile, Peru, and Uruguay, has catalyzed engagement of over 3000 faculty and students in the last ten years. Over 50 significant collaborative research programs have benefitted thousands of preschool children, pioneered new approaches to disaster relief, improved health care, revolutionized public housing, and led to scientific breakthroughs. This model of a small physical footprint exerting large academic influence will be one of the central strategies as Harvard looks toward the future. DOI: 10.18870/hlrc.v3i2.117

  10. POETIKA MLADINSKE PROZE JANE BAUER

    OpenAIRE

    Ferlan, Sandra

    2014-01-01

    V diplomskem delu sem predstavila celoten opus del Jane Bauer: V deželi medenjakov, Groznovilca v Hudi hosti, Izginjevalec čarovnic, Čarobna beseda, Detektivske prigode Fokusa in Kolumne, Skrivnost izropane grobnice in Detektivske prigode Fokusa in Kolumne, V strašljivem hotelu. Dela sem literarno- morfološko razčlenila. Šest analiziranih del sem razvrstila v dva širša tipa mladinske književnosti, in sicer v fantastični tip in realistični tip. V fantastični tip sodijo: V deželi medenjakov,...

  11. Jane Austen: tra brand e desiderio

    OpenAIRE

    Donata Meneghelli

    2014-01-01

    Che Jane Austen, dopo essere giunta a una incontrastata canonizzazione nel pantheon della letteratura occidentale, abbia recentemente intrapreso una   trionfante ascesa nell’ambito della cultura popolare è ormai “una verità universalmente riconosciuta”.   Il saggio analizza i modi, le forme, i supporti e i canali attraverso cui Jane Austen e i suoi testi narrativi (con particolare riferimento a Pride and Prejudice) sono usciti dal cerchio tutto sommato ristretto dell’accademia, dei curric...

  12. An historical ophthalmic study of Jane Austen.

    Science.gov (United States)

    Wilson, Graham A

    2012-11-01

    Today, no other classic novelist has the popularity or power of Jane Austen, and in 2013 the world will celebrate 200 years of her comic masterpiece Pride and Prejudice. Her millions of fans have an abiding fascination with all aspects of her life, including her health and the cause of her death. This historical ophthalmic study of Jane Austen, based on very incomplete medical bibliographic data, finds that she had a mild ocular surface disorder from age 23. This disorder did not significantly impact on her visual performance for writing. There are many references to eyes in her novels, but Jane's eyes and those of her characters cannot contribute further to the debate around the cause of her death at age 41.

  13. HARVARD PROJECT PHYSICS PROGRESS REPORT.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA.

    THIS REPORT OF HARVARD PROJECT PHYSICS PRESENTS DRAFTS OF THREE SPEECHES DELIVERED TO THE AMERICAN ASSOCIATION OF PHYSICS TEACHERS (AAPT) MEETING, FEBRUARY, 1967. THE ADDRESS BY GERALD HOLTON DEALS WITH THE AIMS AND PROGRESS OF THE PROJECT. DISCUSSED ARE (1) PROJECT PARTICIPANTS, (2) AIMS AND CONTENT, (3) THE NEW EMPHASIS, (4) SURVEY OF COURSE…

  14. Rhetoric and Gender in Jane Austen's "Persuasion."

    Science.gov (United States)

    Walzer, Arthur E.

    1995-01-01

    Argues for a reading of Jane Austen's "Persuasion" that undermines Joseph Duffy's reading of the novel as a commentary on shifting social class structures, and which bolsters Nancy Armstrong's reading as a commentary on female voice and the values of the domestic household. Interprets the novel in the light of 18th-century rhetorical…

  15. Jane Butler Kahle: Passion, Determination, and Vision

    Science.gov (United States)

    Scantlebury, Kathryn

    2014-01-01

    In this article, I describe how Jane Butler Kahle's intellectual curiosity, commitment to equity and her ability to use various research approaches, to establish research and networking groups comprised of scholars from diverse backgrounds, theoretical perspectives and geographic locations, to disseminate research outcomes and findings…

  16. On Today: Jane M. Healy, Educational Psychologist.

    Science.gov (United States)

    TECHNOS, 1999

    1999-01-01

    This interview with Jane Healy, an educational psychologist and author, discusses how computers can sometimes negatively affect children's minds. Topics include instructional design in software; the need for objective research; what children will need for success in the future, including critical thinking skills; technology implementation; and…

  17. Was Jane Addams a Promiscuous Pragmatist?

    Science.gov (United States)

    Atkinson, Becky

    2013-01-01

    Contemporary pragmatist and feminist scholars have proposed the possibilities for "changing the theoretical analyses and concrete practices" of both feminism and classical American pragmatism offered by its recuperation through feminism. Particularly, scholarship on Jane Addams has reached back to retrieve her activism, ethics, and…

  18. Exceptional Portable Sundials at Harvard

    Science.gov (United States)

    Schechner, Sara

    2014-06-01

    The Collection of Historical Scientific Instruments at Harvard University has the largest assemblage of sundials in North America. The dials date from the 16th to the 19th centuries, and most are designed to be carried in one’s pocket or put on a window sill. They take advantage of the sun’s changing altitude, azimuth, hour angle, or a combination of the foregoing in order to find the time. Many are also usable at a wide range of latitudes, and therefore are suitable tools for travelers. Fashioned of wood, paper, ivory, brass, and silver, the sundials combine mathematical projections of the sun’s apparent motion with artistry, fashion, and exquisite craftsmanship. This paper will explore the wide variety of sundials and what they tell us about the people who made and used them.

  19. Jane Austen on love and pedagogical power.

    Science.gov (United States)

    Fessenbecker, Patrick

    2011-01-01

    This essay notes initially recent prominence of theories of pedagogy that attempt to "de-mystify" it and reveal troubling power relations, and their subsequent contention that love is impossible in the student-teacher relationship. "Pedagogical" interpretations of Jane Austen's fiction, however, see pedagogy as essential to love. I argue that this is so precisely because of the power dynamics involved; drawing on Jessica Benjamin's psychoanalytic interpretation of G. W. F. Hegel's analysis of the "Lord-Bondsman," I suggest that Austen portrays the loving relationship as inherently involving the occupation and subsequent exchange of roles as superior and inferior, incarnated as "teacher" and "student."

  20. Father Figures in the Novels of Jane Austen

    Science.gov (United States)

    Odeh, Adli

    2011-01-01

    Miniaturist as Jane Austen is, she has depicted the life of a few families. In her letter to her niece, Anna Austen, she writes: "three or four families in a country village is the very thing to work on"(Chapman's Edition, 1970, P.10). Jane's knowledge about these families is, in no way shallow. It is rich in variation and contrasts.…

  1. The History of Miss Jane Pittman

    Directory of Open Access Journals (Sweden)

    Christopher Mulvey

    2006-05-01

    Full Text Available This paper explores the ways in which Ernest J. Gaines uses fiction in The Autobiography of Miss Jane Pittman to write a history of the African American from 1861 to 1961. The “Introduction” sets the novel going, but its direction has already been given in the unusual dedication to his grandmother, stepfather and aunt “who did not walk a day in her life but who taught me the importance of standing” (Gaines iv. The significance for Gaines is that what happened a hundred years ago is part of his present-day lived life.The nineteenth-century novel was possessed by history, and white nineteenth-century novelists found their great subject in the war of European nations that was fought between 1799 and 1815. But that was not an American war nor was it an African American war. For Gaines, the war that makes the great turning point of a nation and a people is the American Civil War, fought from 1861 to 1865. It resulted in a moment of history after which life would not be the same. However, one of the main points that Gaines makes about that great turning point in history is that everything changed and nothing changed. And his main fictional device to establish that truth is to tell the history of the hundred years since Emancipation as the story of one woman. Her autobiography becomes an ethno-biography.The continuity forwards from 1861 is given through the life of one woman, but Gaines’s uses another device to provide a continuity backwards from 1861. The young man who wants to get Miss Jane Pittman’s story upsets her with his persistence: “What you want know about Miss Jane for?’ Mary said. ‘I teach history,’ I said. ‘I’m sure her life’s story can help me explain things to my students.’ ‘What’s wrong with them books you already got?’ Mary said. ‘Miss Jane is not in them,’ I said” (Gaines v. Ernest J. Gaines wrote at a time when historians finally began to recognize that they could get no true history of the

  2. Citing & Referencing Using the Harvard Style: Examples

    OpenAIRE

    Cullen, John G.

    2016-01-01

    This teaching resource supplements 2 videos which are available online on YouTube. These videos are titled: • ‘Citing and referencing using the Harvard Style (Part 1)’ - Available at https://www.youtube.com/watch?v=9X1UjtfgTU8 • Citing and referencing using the Harvard Style (Part 2)’ - Available at https://www.youtube.com/watch?v=Hj_EXIFviZA

  3. Jane Austen: tra brand e desiderio

    Directory of Open Access Journals (Sweden)

    Donata Meneghelli

    2014-12-01

    Full Text Available Che Jane Austen, dopo essere giunta a una incontrastata canonizzazione nel pantheon della letteratura occidentale, abbia recentemente intrapreso una   trionfante ascesa nell’ambito della cultura popolare è ormai “una verità universalmente riconosciuta”.   Il saggio analizza i modi, le forme, i supporti e i canali attraverso cui Jane Austen e i suoi testi narrativi (con particolare riferimento a Pride and Prejudice sono usciti dal cerchio tutto sommato ristretto dell’accademia, dei curricola universitari e dei lettori di professione, per entrare in uno spazio che è quello di YouTube, delle fan communities, della musica pop, dei blog, del romanzo rosa o dell’horror; i percorsi grazie ai quali sono diventati parte delle mitologie popolari del XXI secolo e al tempo stesso un brand di successo intorno al quale ruota una fitta rete di interessi economici (industria cinematografica e televisiva, turismo, editoria…, capace di catalizzare (e sfruttare desideri, proiezioni, aspettative di nuove tipologie di lettori; le inedite modalità di ricezione che caratterizzano questo fenomeno, e soprattutto la fan fiction, situata al punto di convergenza o di frizione tra diversi media (letteratura, cinema, televisione, web e media digitali in genere, tra produttori e consumatori, tra lettura e scrittura, tra strategie commerciali delle corporation e autarchia dei fan, tra “alto” e “basso”. Si tratta di un insieme di trasformazioni che scuote alle fondamenta le nostre consuetudini e le nostre credenze in quanto studiosi di letteratura: da una parte, emerge una nuova configurazione della testualità, euforica, rizomatica, molteplice, che si fa beffe di qualunque metafisica dell’originale e realizza in modo perverso alcune celebri utopie critiche; dall’altra, il caso Austen porta alla luce in maniera emblematica le contraddizioni latenti in qualunque processo di democratizzazione della cultura.

  4. Ta-Tsing-Leu-Lee

    OpenAIRE

    Staunton, George Thomas

    2017-01-01

    Anastatic reprint of Ta-Tsing-Leu-Lee o Sia Leggi Fondamentali del Codice Penale della China, stampato e promulgato a Pekin coll’autorità di tutti gl’Imperatori Ta-Tsing, della presente dinastìa. Tradotto dal chinese da Giorgio Tommaso Staunton, membro della Società reale di Londra […] Versione italiana […] 3 vols. (Milano: dalla Stamperia di Giovanni Silvestri agli Scalini del Duomo n° 994, 1812), Italian translation of George Thomas Staunton, Ta Tsing Leu Lee; Being the Funda...

  5. Jane Austen in the High School Classroom (Open to Suggestion).

    Science.gov (United States)

    Fritzer, Penelope

    1996-01-01

    Argues that Jane Austen's novels lend themselves to the high school curriculum, and that students will discover a leisurely, rural world in which the concerns of the young people are often similar to theirs. (SR)

  6. Review of Barbara K. Seeber, Jane Austen and Animals

    Directory of Open Access Journals (Sweden)

    Lucinda Cole

    2015-03-01

    Full Text Available In this review of Barbara K. Seeber's Jane Austen and Animals (Ashgate, 2013 Lucinda Cole summarizes this foundational book and emphasizes the role of animal studies scholars in linking feminism and environmental issues.

  7. The Hidden Rule: A Critical Discussion of Harvard University's Governing Structure. [A Harvard Watch Report].

    Science.gov (United States)

    Weissman, Robert

    The governing structure of Harvard University is reviewed, and the findings include the following: (1) Harvard's present administrative and governance structure utilize corporate techniques of management that allow the president to diffuse administrative tasks without diffusing power--the difficulty of locating responsibility in the decentralized…

  8. Yang-Lee zeros of the Yang-Lee model

    Science.gov (United States)

    Mussardo, G.; Bonsignori, R.; Trombettoni, A.

    2017-12-01

    To understand the distribution of the Yang-Lee zeros in quantum integrable field theories we analyse the simplest of these systems given by the 2D Yang-Lee model. The grand-canonical partition function of this quantum field theory, as a function of the fugacity z and the inverse temperature β, can be computed in terms of the thermodynamics Bethe Ansatz based on its exact S-matrix. We extract the Yang-Lee zeros in the complex plane by using a sequence of polynomials of increasing order N in z which converges to the grand-canonical partition function. We show that these zeros are distributed along curves which are approximate circles as it is also the case of the zeros for purely free theories. There is though an important difference between the interactive theory and the free theories, for the radius of the zeros in the interactive theory goes continuously to zero in the high-temperature limit β → 0 while in the free theories it remains close to 1 even for small values of β, jumping to 0 only at β = 0 .

  9. Jane Eyre, Past and Present Jane Eyre, d’hier à aujourd’hui

    Directory of Open Access Journals (Sweden)

    Armelle Parey

    2009-10-01

    Full Text Available The present collection of articles along with a few additional contributions contains the proceedings of a conference held at the university of Caen Basse-Normandie, France in May 2004. Entitled “Jane Eyre, Past and Present”, its aim was to study the posterity of Charlotte Brontë’s novel and/or character since its publication in 1847. That two-thirds of the texts studied in this volume were published in the last decade of the twentieth century attests to the fact that rewriting has become a m...

  10. The Anonymous Jane Austen: Duelling Canons

    Directory of Open Access Journals (Sweden)

    Edward Copeland

    2017-12-01

    Full Text Available This essay initially addresses some theoretical concepts such as adaptation and appropriation. I intend to analyze how Jane Austen herself indulged in her own appropriations from the woman’s canon, in particular through a story entitled Guilt Pursued by Conscience, a tale she found in the “Lady’s Magazine” of 1802. I will show that this tale that claimed Austen’s particular attention was re-appropriated in Emma (although in the broadest sense of parody and, to a lesser extent, in Sense and Sensibility. The second part of the essay, instead, will move on to analyze how novelists of the generation that followed Austen felt free to import dialogue, characters, and plots from Austen’s works, showing no obligation to their source, just as she had done with the “Lady’s” tale. I will mention and comment on a series of novels, especially from the silver fork school, that draw from Austen’s plot, characters and happenings without acknowledging their legacy to their predecessor.

  11. T.D Lee and Lisa Randall visit ATLAS

    CERN Multimedia

    Pauline Gagnon

    Professor Tsung-Dao Lee, who received the Nobel Prize for Physics in 1957 for postulating that parity is not conserved in weak interactions, visited the ATLAS detector this month. He is seen here in the company of Peter Jenni, spokesperson for ATLAS. T.D. Lee is still very active at over 80, pursuing his theory work to this day. Professor Lisa Randall from Harvard University, the well-known theorist behind the Randall-Sundrum theory for extra dimensions, was also part of the group visiting the ATLAS detector. She is seen here with Fabiola Gianotti, deputy spokesperson for ATLAS. Lisa Randall's two initial papers have been quoted both more than 2500 times, making her the most cited theoretical physicist in the world in the last five years as of last autumn - a total of about 10,000 citations! One wonders here if Peter is pointing to a CP-violating graviton spotted in the ATLAS cavern... From left to right: Fabiola Gianotti, Gustaaf Brooijmans, convener of the ATLAS Exotics physics gro...

  12. Harvard and the Academic Glass Ceiling

    Science.gov (United States)

    Drago, Robert

    2007-01-01

    Drew Gilpin Faust was recently appointed president of Harvard University, and is the first female to hold the position. Women now lead half of the eight institutions that make up the Ivy League. But focusing on highly accomplished women such as Faust misses a larger point. Women may be taking faculty positions in record numbers, but most of those…

  13. Harvard is Spending, Education Needs Mending

    Directory of Open Access Journals (Sweden)

    2001-01-01

    Full Text Available Nature leads with happy news about a spending spree at Harvard University. Yet another study, this time from a student perspective, argues that graduate education in the U.S. is deeply flawed, reports Science in this week’s lead story.

  14. Jane Austen and Addison's disease: an unconvincing diagnosis.

    Science.gov (United States)

    White, K G

    2009-12-01

    Jane Austen's letters describe a two-year deterioration into bed-ridden exhaustion, with unusual colouring, bilious attacks and rheumatic pains. In 1964, Zachary Cope postulated tubercular Addison's to explain her symptoms and her relatively pain-free illness. Literary scholars later countered this posthumous diagnosis on grounds that are not well substantiated, while medical authors supported his conclusion. Important symptoms reported by contemporary Addison's patients-mental confusion, generalised pain and suffering, weight loss and anorexia-are absent from Jane Austen's letters. Thus, by listening to the patient's perspective, we can conclude it is unlikely that Addison's disease caused Jane Austen's demise. Disseminated bovine tuberculosis would offer a coherent explanation for her symptoms, so that Cope's original suggestion of infective tuberculosis as the cause of her illness may have been correct.

  15. Exploring resident-empowered meetingplaces in Dutch neighbourhoods : by Jane Jacobs Walking Action-research methodology

    NARCIS (Netherlands)

    Sanders, F.C.

    2016-01-01

    The ‘Jane Jacobs Walk’ organization as one of the Jane Jacobs (1916-2006) heritage initiative supported three Jane Jacobs Walks of certified Fred Sanders in the period 2011 - 2014 in Amsterdam neighbourhoods. These walks helped residents to explore resident-empowered meeting-places and activities in

  16. Harvard University High Energy Physics progress report

    International Nuclear Information System (INIS)

    1992-01-01

    The principal goals of this work are to carry out forefront programs in high energy physics research and to provide first rate educational opportunities for students. The experimental program supported through HEPL is carried out at the major accelerator centers in the world and addresses some of the most important questions in high energy physics. The program is based at Harvard's High Energy Physics Laboratory, which has offices, computing facilities, and engineering support, and both electronics and machine shops

  17. A guide to the Harvard referencing system.

    Science.gov (United States)

    Dwyer, M

    This article explains how to reference an academic work using the Harvard system. Instructions comply with the relevant British standards, i.e. BS 5605:1990, BS 1629:1989 and BS 6371:1983. The importance of referencing in an approved manner is discussed and problem areas such as joint authors, corporate authorship and unpublished works are examined. The issue of second-hand references that are not addressed by the standards is also explained.

  18. Jane Marcet and Harriet Martineau: Pioneers of Economics Education.

    Science.gov (United States)

    Shackleton, J. R.

    1990-01-01

    Presents the lives and careers of Jane Marcet and Harriet Martineau and their contributions to the dissemination and popularization of political economics in early nineteenth-century education. Places their ideas about laissez-faire capitalism in historical context. Stresses the significance of their role as female writers and educators. (CH)

  19. Jane Fonda: Repercussions of Her 1972 Visit to North Vietnam

    Science.gov (United States)

    2010-04-01

    prisoner said, “we almost went fucking crazy.” 45 She referred to the pilots as “American imperialist air raiders”. 46 The guards broadcast a...taped recording of Fonda singing with a group of women; the song was called “ Fuck the Army”. 47 The much-publicized meeting of Jane Fonda

  20. Jane Austen ja viktoriaanluse come back / Mihkel Mutt

    Index Scriptorium Estoniae

    Mutt, Mihkel, 1953-

    1996-01-01

    Jane Austeni teoste jätkuvalt kasvavast populaarsusest, raamatute põhjal lavastatud filmidest, viktoriaanlusest ja muust - inspireerituna filmist "Neli pulma ja üks matus" ("Four Weddings and a Funeral", rež̓issöör Mike Newell, Suurbritannia 1994)

  1. Searching for Bill and Jane: Electronic Full-Text Literature.

    Science.gov (United States)

    Still, Julie; Kassabian, Vibiana

    1998-01-01

    Examines electronic full-text literature available on the World Wide Web and on CD-ROM. Discusses authors and genres, electronic texts, and fees. Highlights Shakespeare, Jane Austen, and nature writing. Provides a bibliography of Web guides, specialized Shakespeare pages, and pages dealing with the Shakespeare authorship debate and secondary…

  2. Induced Recall of Jane Austen's Novels: Films, Television, Videos.

    Science.gov (United States)

    Diaz de Chumaceiro, Cora L.

    2000-01-01

    Notes that the popularity of Jane Austen adaptations in theaters, television, and videos increases the probability that patients and therapists may recall these movies in treatment. Underscores excerpts from a comparison of an Austen novel with the psychoanalytic process and highlights available film adaptations in video format. (SC)

  3. Interjections in the Performance of Jane Austen's "Pride and Prejudice"

    Science.gov (United States)

    O'Connell, Daniel C.; Kowal, Sabine

    2010-01-01

    Three data sets of primary and secondary interjections were compared: (1) the original interjections written into the text of Jane Austen's (1813/1994) novel "Pride and prejudice"; (2) the interjections read aloud in commercial recordings by six professional readers of the entire text of the novel; (3) the interjections spoken by actresses and…

  4. Women Consciousness Exploration in Jane Austen and Her Works

    Science.gov (United States)

    He, Xiaojun; Liao, Lina

    2015-01-01

    Jane Austen is one of the greatest realistic novelists in English literature of the 19th century. Austen is contrary to consciousness of man centrism and traditional values of masculine writers before her time. All her 6 novels are concerned with love and marriage; they truthfully reflect women life of her age, reveals her feminine consciousness…

  5. Living with diversity in Jane-Finch

    Directory of Open Access Journals (Sweden)

    Donya Ahmadi

    2017-11-01

    seeks to add to our understanding of urban diversity, as perceived and experienced by those who inhabit, frequent and govern urban areas. It answers the following primary research question: How is diversity experienced at the neighbourhood level, as (a discourse, (b social reality, and (c practice? Diversity as discourse refers to the public narratives around diversity, while diversity as social reality concerns the descriptive characteristics that render an area diverse. Diversity as practice refers to policies, programs and local practices that aim towards managing diversity (see also Berg and Sigona, 2013. The research question is investigated in four interconnected chapters, which engage with the three formerly mentioned dimensions to various degrees. The study further makes use of a variety of qualitative and participatory techniques (i.e. qualitative interviews, roundtable talks, participant observations, and focus groups to gather rigorous empirical data on living with and managing diversity in an inner-suburban neighbourhood of Toronto, namely Jane-Finch.

  6. Jane Eyre between the Wars Jane Eyre entre les deux guerres

    Directory of Open Access Journals (Sweden)

    Patsy Stoneman

    2009-07-01

    Full Text Available L’un des héritages que Charlotte Brontë laissa derrière elle avec son roman Jane Eyre, c’est une trame qui fut indéfiniment recyclée dans le roman féminin. Une femme jeune, isolée et désargentée rencontre un homme plus riche et plus âgé qu’elle, au tempérament morose et au passé mystérieux dans lequel se trouve une épouse démente et mauvaise. Dans le monde de Charlotte Brontë, la société offre peu d’alternatives au mariage pour une femme qui ne peut compter que sur elle-même pour subvenir à ses besoins, et même le dénouement tranché de Jane Eyre n’est qu’une version plus égalitaire du mariage traditionnel. Sa structure triangulaire, toutefois, s’est avérée fertile pour les écrivains qui examinèrent les relations hommes/femmes dans des époques sociales ultérieures. Dans l’Angleterre d’entre-deux-guerres, les femmes de la classe moyenne étaient, comme le formule Virginia Woolf, « on the bridge » entre la maison privée et le monde professionnel. La plupart des obstacles légaux qui leur barraient l’accès à l’instruction et à l’emploi disparaissaient, mais l’éthos de la domesticité imprimait encore sa marque sur les attentes émotionnelles des femmes. Dans cet article, j’examine quatre romans qui utilisent l’intrigue de Jane Eyre afin de tracer les contours des possibilités qui s’offraient aux femmes à cette époque. Il s’agit de Vera d’Elizabeth von Arnim (1921, The Weather in the Streets de Rosamond Lehmann (1936, South Riding de Winifred Holtby (1936 et Rebecca de Daphne du Maurier (1938. La distinction que Tania Modleski dresse entre la romance (‘romance’ – dans laquelle la peur ou le dégoût initial de l’héroïne pour le héros se transforme en amour – et le gothique (‘gothic’ – où le processus est inverse – souligne que ces romans modernes ne peuvent envisager autre chose qu’un dénouement gothique à une situation à l’origine romantique

  7. The Earl Lee Street Art Campaign

    Science.gov (United States)

    Bubba

    2013-01-01

    This article describes a catchy phrase with more to its meaning than first view. A slogan "All the girls love Earl Lee," appears in street art around the world. Earl Lee is a lovable, handsome man who owns the fictitious Earl Lube industries. Originally intended to bring a smile to people's faces at a time when there wasn't much to smile…

  8. Characterization of Phenolic Compounds in Wine Lees

    Directory of Open Access Journals (Sweden)

    Ye Zhijing

    2018-03-01

    Full Text Available The effect of vinification techniques on phenolic compounds and antioxidant activity of wine lees are poorly understood. The present study investigated the antioxidant activity of white and red wine lees generated at early fermentation and during aging. In this study, the total phenol content (TPC, total tannin content (TTC, mean degree of polymerization (mDP, and antioxidant activities of five white and eight red wine lees samples from different vinification backgrounds were determined. The results showed that vinification techniques had a significant (p < 0.05 impact on total phenol and tannin content of the samples. White wine lees had high mDP content compared with red ones. Catechin (50–62% and epicatechin contents were the predominant terminal units of polymeric proanthocyanidin extracted from examined samples. Epigallocatechin was the predominant extension unit of white wine lees, whereas epicatechin was the predominant compound in red wine marc. The ORAC (oxygen radical absorbance capacity assay was strongly correlated with the DPPH (α, α-diphenyl-β-picrylhydrazyl assay, and the results showed the strong antioxidant activities associated with red wine lees (PN > 35 mg Trolox/g FDM (PN: Pinot noir lees; FDM: Freeze-dried Material. This study indicates that tannin is one of the major phenolic compounds available in wine lees that can be useful in human and animal health applications.

  9. Tim Berners-Lee during the WSIS

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Tim Berners-Lee stands in front of the first web server at the Geneva Palexpo during the World Summit on the Information Society (WSIS) in 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  10. Characterization of Phenolic Compounds in Wine Lees.

    Science.gov (United States)

    Zhijing, Ye; Shavandi, Amin; Harrison, Roland; Bekhit, Alaa El-Din A

    2018-03-25

    The effect of vinification techniques on phenolic compounds and antioxidant activity of wine lees are poorly understood. The present study investigated the antioxidant activity of white and red wine lees generated at early fermentation and during aging. In this study, the total phenol content (TPC), total tannin content (TTC), mean degree of polymerization (mDP), and antioxidant activities of five white and eight red wine lees samples from different vinification backgrounds were determined. The results showed that vinification techniques had a significant ( p 35 mg Trolox/g FDM) (PN: Pinot noir lees; FDM: Freeze-dried Material). This study indicates that tannin is one of the major phenolic compounds available in wine lees that can be useful in human and animal health applications.

  11. Crimson Tide: The Harvard Books on Astronomy

    Science.gov (United States)

    Lindner, R. P.

    2001-12-01

    The Harvard Books on Astronomy, a series of crimson clad, fully illustrated volumes, cornered, for more than a generation, the market of readers interested in astronomy. A large number of astronomers owe their first serious initiation to the literature of astronomy to these books. Their style, presentation, design, and tone marked a clear departure from the inherited traditions in the field. Each summed up a field, awarded points for merit, and staked out paths for future study. No doubt each of the more mature readers of this abstract has his or her favorite volume, and even his or her own favorite edition of a particular volume. How the volumes evolved and what happened to the series with Harlow Shapley's retirement are not only questions in the history of the book but also form a commentary on the standards of scientific writing for the educated public. For this the major evidence comes from the volumes by Shapley himself, Leo Goldberg and Lawrence Aller, and the Boks. This paper discusses the origins of the series, the purpose of the works, the varying successes of the volumes, and the impact they had on the future astronomical community. In part, this is a contribution to the impact of Harlow Shapley upon the wider field and the role of Harvard in the American astronomical community. It is also a meditation upon the ways of recruitment into the field and forming ways of looking at research problems.

  12. Jane Jacobs' ‘Cities First’ Model and Archaeological Reality

    OpenAIRE

    Smith, Michael E.; Ur, Jason Alik; Feinman, Gary M.

    2014-01-01

    In The Economy of Cities, Jane Jacobs conjectured that the world's first cities preceded the origins of agriculture, a proposition that was most recently revived by Peter Taylor in the pages of this journal. Jacobs' idea was out of line with extant archaeological findings when first advanced decades ago, and it remains firmly contradicted by a much fuller corpus of data today. After a review of how and why Jacobs formulated her ‘cities first’ model, we review current archaeological knowledge ...

  13. The Statecraft of Singapore's Lee Kuan Yew

    National Research Council Canada - National Science Library

    Toh, K

    1996-01-01

    .... The ejection of Singapore from the Federation led Lee to focus on two strategic goals: the survival of Singapore as an independent state while simultaneously pursuing nation-building under the threats of communism and internal ethnic conflicts...

  14. Higher-derivative Lee-Wick unification

    International Nuclear Information System (INIS)

    Carone, Christopher D.

    2009-01-01

    We consider gauge coupling unification in Lee-Wick extensions of the Standard Model that include higher-derivative quadratic terms beyond the minimally required set. We determine how the beta functions are modified when some Standard Model particles have two Lee-Wick partners. We show that gauge coupling unification can be achieved in such models without requiring the introduction of additional fields in the higher-derivative theory and we comment on possible ultraviolet completions.

  15. The Manifestations of Military Gender Role Issue on Ridley Scott's G. I. Jane Movie

    OpenAIRE

    PUTRA, ABEDNEGO ANGGA JURIAN

    2015-01-01

    Keywords: gender discrimination, women in military, feminism, G.I. Jane movie. Gender discrimination threats the equality of women's role. One of the causes of gender discrimination is patriarchal system in society. A movie entitled G.I. Jane reveals some causes and manifestations of gender discrimination in military.This research applies Feminism approach to analyze a movie entitled G.I. Jane. This study also applies the concept of gender role, women in military, and film studies.The result ...

  16. Historical contributions from the Harvard system to adult spine surgery.

    Science.gov (United States)

    Schoenfeld, Andrew J

    2011-10-15

    Literature review. To document the historical contributions from the Harvard Medical School system to the field of adult spine surgery. Despite the fact that significant contributions to the discipline of spinal surgery have derived from the Harvard system, no prior study documents the history of the Harvard spine services in a cohesive narrative. This historical perspective reviews the history of adult spine surgery within the Harvard system and outlines the significant contributions made by orthopedic and neurosurgical practitioners to the field. Literature reviews were performed from historical works, as well as scientific publications to fashion a cohesive review covering the history of spine surgery at Harvard from the early 19th century to the present. The development of the spine surgical services at the three main Harvard hospitals, and significant spine surgical personalities within the system, are discussed, including W. Jason Mixter, MD, Joseph S. Barr Sr., MD, and Marius N. Smith-Petersen, MD. Substantial developments that have arisen from the Harvard teaching hospitals include the recognition of disc herniation as the cause of radicular symptoms in the lower extremities, the description of lumbar discectomy as a surgical treatment for radicular pain, osteotomy for the correction of spinal deformity, and the first attempt to create a systematic algorithm capable of informing treatment for cervical spine trauma. Despite humble beginnings, the surgeons and scientists at Harvard have influenced nearly every facet of spine surgery over the course of the last two centuries.

  17. The Early History of Blacks at Harvard Medical School.

    Science.gov (United States)

    Takaki, Ronald T.

    1995-01-01

    Discusses the history of the admission of African Americans at the Harvard Medical School and the racial prejudice that followed. The author reveals how Harvard medical students of the time believed that blacks were intellectually inferior and that having black students at the school would devalue the school and their diplomas. (GR)

  18. Harvard Business Schoolis töötav ainus eestlane Toomas Laarits / intervjueerinud Luise Savik

    Index Scriptorium Estoniae

    Laarits, Toomas

    2011-01-01

    Intervjuu Harvard College'i bakalaureuseõppe lõpetanud ja Harvard Business Schoolis kahe õppejõu assistendina töötava eestlase Toomas Laaritsaga Harvard Business Schooli magistriõppest ja elust tudengina Harvardis

  19. Use of Awamori-pressed Lees and Tofu Lees as Feed Ingredients for Growing Female Goats

    Directory of Open Access Journals (Sweden)

    Itsuki Nagamine

    2012-12-01

    Full Text Available Okinawan Awamori is produced by fermenting steamed indica rice with black mold, yeast, and water. Awamori-pressed lees is a by-product of the Awamori production process. Tofu lees is a by-product of the Tofu production process. This research consisted of two experiments conducted to elucidate whether or not dried Awamori-pressed lees and Tofu lees can be used as a mixed feed ingredient for raising female goats. In experiment 1, digestion trials were conducted to ascertain the nutritive values of dried Awamori-pressed lees and dried Tofu lees for goats. The digestible crude protein (DCP and total digestible nutrients (TDN contents of dried Awamori-pressed lees and Tofu lees were 22.5%, 22.5% (DCP, and 87.2%, 94.4% (TDN respectively. In experiment 2, 18 female goats (Japanese Saanen×Nubian, three months old, body weight 15.4±0.53 kg were divided into three groups of six animals (control feed group (CFG, Awamori-pressed lees mixed feed group (AMFG, Tofu lees mixed feed group (TMFG. The CFG control used feed containing 20% soybean meal as the main protein source, while the AMFG and TMFG treatments used feed mixed with 20% dried Awamori-pressed lees or dried Tofu lees. The groups were fed mixed feed (volume to provide 100 g/d increase in body weight twice a day (10:00, 16:00. The klein grass hay and water was given ad libitum. The hay intake was measured at 08:00 and 16:00. Body weight and size measurements were taken once a month. At the end of the experiment, a blood sample was drawn from the jugular vein of each animal. The DCP and TDN intakes in AMFG and TMFG showed no significant difference to the CFG. Cumulative measurements of growth in body weight, withers height, chest depth, chest girth, and hip width over the 10 mo period in the AMFG and TMFG were similar to the CFG. By contrast, cumulative growth in body length and hip height in the AMFG and TMFG tended to be larger than the CFG. Cumulative growth in chest width in the AMFG was

  20. Concrete Security for Entity Recognition: The Jane Doe Protocol

    DEFF Research Database (Denmark)

    Lucks, Stefan; Zenner, Erik; Weimerskirch, Andre

    2008-01-01

    Entity recognition does not ask whether the message is from some entity X, just whether a message is from the same entity as a previous message. This turns turns out to be very useful for low-end devices. The current paper proposes a new protocol – the “Jane Doe Protocol” –, and provides a formal...... proof of its concrete security. The protocol neither employs asymmetric cryptography, nor a trusted third party, nor any key pre-distribution. It is suitable for light-weight cryptographic devices such as sensor network motes and RFID tags....

  1. Recreating Jane: “Austenland” and the Regency Theme Park

    OpenAIRE

    Maddalena Pennacchia

    2017-01-01

    In the maze of Austen’s ever-expanding textuality – with its prequels, sequels, rewritings and adaptations – it may be worth paying attention to an unpretentious little book by Shannon Hale titled Austenland (2007). The story is about the adventures of a New Yorker thirty-something with a name that says it all: Jane. Being obsessed with Mr Darcy as played by Colin Firth, she decides to be healed by her excessive Austenian fantasies (or rather to indulge in them for the last time) by spending ...

  2. Jane Austen's (1775-1817) references to headache: fact and fiction.

    Science.gov (United States)

    Larner, A J

    2010-11-01

    References to headache in Jane Austen's works, both fictional and non-fictional, and in biographical works undertaken by Austen family members have been collated. These multiple references suggest that Jane Austen used headache as a narrative device to reflect not only physiological bodily processes but also psychological states, possibly based on her own experience of headache and that of female relations and acquaintances.

  3. "A transcript of actual life": headache in the novels of Jane Austen.

    Science.gov (United States)

    Larner, Andrew J

    2010-04-01

    References to headache in the novels of Jane Austen have been examined. Nine characters, all female, suffer headache at one time or another, often in association with emotionally stressful situations. As an authorial device, headache may have served Jane Austen as a culturally sanctioned form of bodily expression.

  4. Clumsy City by Design : A Theory for Jane Jacobs’ Imperfect Cities?

    NARCIS (Netherlands)

    Schmitt, Sarah-Maria; Hartmann, T.

    2016-01-01

    How do different concepts of justice correspond with the principles of diversity in cities introduced by Jane Jacobs? This contribution connects Jane Jacobs’ ideas on the diverse city with Mary Douglas’ Cultural Theory and its concept of clumsy solutions. According to Douglas’ Cultural Theory, every

  5. Lucy Snowe : première réécriture de Jane Eyre Lucy Snowe: the First Rewriting of Jane Eyre

    Directory of Open Access Journals (Sweden)

    Elise Ouvrard

    2009-10-01

    Full Text Available While reading Villette, published by Charlotte Brontë in 1853, one cannot help thinking of Jane Eyre, the eponymous heroine of the novel published by the same author in 1847. The link means much more than the thematic and stylistic unity of a writer’s works. Lucy Snowe, the heroine of Villette, constitutes in fact the rewriting of Jane Eyre. Such rewriting is characterized by continuity as can be shown by the physical appearance, the strength of character and the progression of both heroines. However, there would be no interest in reproducing Jane Eyre identically and the outcome of the two novels presents a clear rupture, a rupture which has to be deciphered in order to understand the purpose of Charlotte Brontë in creating the filiation between Lucy Snowe and Jane Eyre.

  6. Jane Doe: a cautionary tale for case reports.

    Science.gov (United States)

    Putnam, Frank W

    2014-12-01

    Historically, clinical case reports have played an essential role in the professional communication of medical and psychiatric knowledge. Case reports continue to play important roles in the initial identification of new syndromes or unusual variants of established conditions. Case reports and case series also serve to alert clinicians to preliminary evidence of the efficacy of novel treatments or adaptations to new populations. The Jane Doe Case provides a seminal example of the ethical/medico-legal dilemma arising from a patient's right to confidentiality versus the principle of independent review/replication as a necessary requirement for scientific credibility. As a result of being the subject of dueling case reports concerning the validity of her delayed recall of childhood sexual abuse, Jane Doe's identity was revealed. Consequently, she suffered significant emotional distress, bankruptcy, and the end of her career as a naval officer and aviator. Current medical journal guidelines call for protection of confidentiality of the patient's identity; yet, scientific credibility requires the possibility of an independent outside review if there are legitimate reasons to question facts or claims advanced in a case report. A potential solution is proposed as a starting point for resolving the dilemma posed for case study subjects and authors by the conflicting requirements of patient confidentiality and, if warranted, the possibility of an independent scientific review. © The Author(s) 2014.

  7. Recreating Jane: “Austenland” and the Regency Theme Park

    Directory of Open Access Journals (Sweden)

    Maddalena Pennacchia

    2017-12-01

    Full Text Available In the maze of Austen’s ever-expanding textuality – with its prequels, sequels, rewritings and adaptations – it may be worth paying attention to an unpretentious little book by Shannon Hale titled Austenland (2007. The story is about the adventures of a New Yorker thirty-something with a name that says it all: Jane. Being obsessed with Mr Darcy as played by Colin Firth, she decides to be healed by her excessive Austenian fantasies (or rather to indulge in them for the last time by spending all her savings on a English Regency Theme park that promises to offer Janeites a real full immersive Austen experience. What interests me in this post-Austenian story is the embedded discourse of leisure and tourism in the age of participatory culture, when an everywoman like Jane brings to the fore the need to be more involved in re-creative activities that are triggered by reading Austen’s novels.

  8. Ambivalence and Ambiguity in The Autobiography of Miss Jane Pittman

    Directory of Open Access Journals (Sweden)

    Monica Michlin

    2006-05-01

    Full Text Available This close reading of the text highlights how Miss Jane, in her double role as protagonist and narrator, shows considerable ambivalence towards friend and foe alike, with the result that the apparently transparent ideological meaning of entire episodes is blurred by what some critics have merely put down to “conservatism.” I examine Miss Jane’s almost constant suppression of emotion, and frequent displays of ambivalence towards other black people; her ambiguous relationship to oppressive, but familiar whites like Albert Cluveau or Robert Samson; and her conflicted relation to black heroes and heroics. Is the leading character a variation on the “mammy” who has internalized racist figures of speech, and uses contradictory images that undermine black heroics and validate white oppression? Or is Gaines’s point to undo the “retrick” of heroics and of alienation alike, and, against of backdrop of constant, ordinary destruction of black lives, to cast the adult Miss Jane as a Brer Rabbit-like figure, for whom survival and resistance are both dialectically connected and opposed? Is there a contradiction between her “progress” towards resistance shown in the last section, and her metadiscursive comments in the present, and does her literally walking out of her own story give a conclusive meaning to her narrative, or does it point to the author’s not having been able to resolve the ambivalence and ambiguities within the text?

  9. Hysteria behind the scenes: Jane Avril at the Salpetriere.

    Science.gov (United States)

    Bonduelle, M; Gelfand, T

    1999-04-01

    Jane Avril (1868-1943), the famous dancer of the Moulin Rouge, immortalized by Toulouse-Lautrec, left behind published Memoires (1933). Trustworthy and written with verve, they include an account of her admission to Charcot's service at the Salpetriere in December 1882. There she was kept until June 1884, not so much because of illness but to protect her from her mother's abuse. Jane Avril provides unvarnished testimony of the daily life of the women with hysteria among whom she lived. She wrongly accuses them of simulation. But she accurately portrays the rivalry of the 'crazy girls' who vied to become the center of attention, and she sheds light on the factors that came together to make hysteria contagious (she herself escaped), the loading of symptomatology and the cultivation of the ailment. Charcot has been criticized on this score, since he showed his recognition of the underlying process when he pronounced isolation to be necessary to treatment. If Charcot accommodated hysteria, the ailment amply rewarded him with a fame that continues to this day to overshadow his achievement in neuropathology that he brilliantly forged using the "anatomo-clinical method."

  10. On the linear programming bound for linear Lee codes.

    Science.gov (United States)

    Astola, Helena; Tabus, Ioan

    2016-01-01

    Based on an invariance-type property of the Lee-compositions of a linear Lee code, additional equality constraints can be introduced to the linear programming problem of linear Lee codes. In this paper, we formulate this property in terms of an action of the multiplicative group of the field [Formula: see text] on the set of Lee-compositions. We show some useful properties of certain sums of Lee-numbers, which are the eigenvalues of the Lee association scheme, appearing in the linear programming problem of linear Lee codes. Using the additional equality constraints, we formulate the linear programming problem of linear Lee codes in a very compact form, leading to a fast execution, which allows to efficiently compute the bounds for large parameter values of the linear codes.

  11. Translation Collective and Illustration: aesthetic film creation from Jane Austen

    Directory of Open Access Journals (Sweden)

    Lemuel da Cruz Gandara

    2015-08-01

    Full Text Available http://dx.doi.org/10.5007/2175-7917.2015v20n2p67 From metonymic clippings of the novels Sense and Sensibility (1811, Pride and Prejudice (1813, Emma (1815 and Persuasion (1817, all written by the English author Jane Austen (1775-1817, we propose a comparative analysis among the literary texts, the illustrations by Hugh Thomson at the end of the nineteenth century and the film footage created between 1995 and 2005. Our goal is to confront tickets to find similarities and differences dialogic between them. This perspective reveals the interpretations made by many readers over the years and the receptions of the English writer in different contexts and media. Our critical and theoretical reflection is based on studies of the Russian philosopher Mikhail Bakhtin about the aesthetics of literary creation and amplifies the concepts of literary cinema, collective translation and aesthetics of film creation.

  12. Statistical study of some Lee galaxy groups

    Science.gov (United States)

    Mohamed, Sabry A.; Fouad, Ahmed M.

    2017-12-01

    Compact groups of galaxies are systems of small number of galaxies close to each other. They are a good laboratory to study galaxy properties, such as structure, morphology and evolution which are affected by the environment and galaxy interactions. We applied the tree clustering technique (the Euclidean separation distance coefficients) to test the physical reality of groups and used certain criteria (Sabry et al., 2009) depending on the physical attributes of the galaxies. The sample of the data is the quintets groups of Lee compact groups of galaxies (Lee et al., 2004). It is based on a modified version of Hickson's criteria (Hickson, 1982). The results reveal the membership of each galaxy and how it is related to its group. The tables of groups and their members are included. Our results indicates that 12 Groups are real groups with real members while 18 Groups have one galaxy that has attribute discordant and should be discarded from its group.

  13. Instability of the Lee-Wick bounce

    International Nuclear Information System (INIS)

    Karouby, Johanna; Brandenberger, Robert; Qiu, Taotao

    2011-01-01

    It was recently realized [Y. F. Cai, T. t. Qiu, R. Brandenberger, and X. m. Zhang, Phys. Rev. D 80, 023511 (2009).] that a model constructed from a Lee-Wick type scalar field theory yields, at the level of homogeneous and isotropic background cosmology, a bouncing cosmology. However, bouncing cosmologies induced by pressureless matter are in general unstable to the addition of relativistic matter (i.e. radiation). Here we study the possibility of obtaining a bouncing cosmology if we add radiation coupled to the Lee-Wick scalar field. This coupling in principle would allow the energy to flow from radiation to matter, thus providing a drain for the radiation energy. However, we find that it takes an extremely unlikely fine-tuning of the initial phases of the field configurations for a sufficient amount of radiative energy to flow into matter. For general initial conditions, the evolution leads to a singularity rather than a smooth bounce.

  14. Lipid composition of lees from Sherry wine.

    Science.gov (United States)

    Gómez, Maria Ester; Igartuburu, José M; Pando, Enrique; Luis, Francisco Rodríguez; Mourente, Gabriel

    2004-07-28

    In this paper, we describe the study and characterization of the lipids from lees of Sherry wine, one of the main byproducts from the wine-making industry in the Jerez/Xeres/Sherry denomination of the origin zone in Jerez de la Frontera, Spain. The lipid content, extractability, classification, fatty acid composition, and its main chemical characteristics have been determined in order to evaluate their potential use as a food or food additive. Copyright 2004 American Chemical Society

  15. Statistical study of some Lee galaxy groups

    Directory of Open Access Journals (Sweden)

    Sabry A. Mohamed

    2017-12-01

    Full Text Available Compact groups of galaxies are systems of small number of galaxies close to each other. They are a good laboratory to study galaxy properties, such as structure, morphology and evolution which are affected by the environment and galaxy interactions. We applied the tree clustering technique (the Euclidean separation distance coefficients to test the physical reality of groups and used certain criteria (Sabry et al., 2009 depending on the physical attributes of the galaxies. The sample of the data is the quintets groups of Lee compact groups of galaxies (Lee et al., 2004. It is based on a modified version of Hickson’s criteria (Hickson, 1982. The results reveal the membership of each galaxy and how it is related to its group. The tables of groups and their members are included.Our results indicates that 12 Groups are real groups with real members while 18 Groups have one galaxy that has attribute discordant and should be discarded from its group. Keywords: Galaxies, Cluster analysis, Galaxy groups, Lee galaxy groups

  16. The Austenisation of Sensibility & the Darcyfication of Jane Austen: A Reflection.

    Directory of Open Access Journals (Sweden)

    Kirpal Singh

    2009-05-01

    Full Text Available Review essay examining Jane Austen's place in literary history, and her attitudes to deeply felt emotion, unpleasant aspects of contemporary life, and sexuality. (Non-refereed article

  17. Screening Jane. When History, Biography and Fiction create a Cinematic Life.

    Directory of Open Access Journals (Sweden)

    Roberta Grandi

    2015-07-01

    Full Text Available This paper analyzes the interesting technique of adaptation of the film Becoming Jane, a biopic on the life of Jane Austen, released in 2007. Loosely based on Jon Spence's biography Becoming Jane Austen, the film faces the problem of the scarcity of information on Jane Austen's life through a technique that, if not original nor always satisfying, is nevertheless worth being studied. By recurring to the character descriptions and the anecdotes narrated in the novels, the film (and Spence's book too "fills in the blanks" in Austen's life by adding touches of romance with questionable historical accuracy and fictionalizes the writer's biography in order to adapt it to the stereotype of modern romantic film heroines.

  18. Channeling Jane Austen: how it helped me become a better psychotherapist.

    Science.gov (United States)

    Carver, Christi R

    2014-08-01

    The influences on a therapist are many. This article illustrates how a 19th-century novelist, Jane Austen, informs the work of a nurse therapist in the 21st century. The characters in a Jane Austen novel provide perspectives from setting boundaries to handling feelings. Austen's characters promote an acceptance of less attractive qualities in others and in oneself that can benefit the therapy. Copyright 2014, SLACK Incorporated.

  19. The Harvard Fatigue Laboratory: Contributions to World War II

    Science.gov (United States)

    Folk, G. Edgar

    2010-01-01

    The war contributions of the Harvard Fatigue Laboratory in Cambridge, MA, were recorded in 169 Technical Reports, most of which were sent to the Office of the Quartermaster General. Earlier reports were sent to the National Research Council and the Office of Scientific Research and Development. Many of the reports from 1941 and later dealt with…

  20. Framework for Sustaining Innovation at Baker Library, Harvard Business School

    Science.gov (United States)

    Dolan, Meghan; Hemment, Michael; Oliver, Stephanie

    2017-01-01

    Baker Library at Harvard Business School is increasingly asked by the school's faculty to create custom digital information products to enhance course assignments and to find novel ways of electronically disseminating faculty research. In order to prioritize these requests, as well as facilitate, manage, and track the resulting projects, the…

  1. Harvard Boycott Turns out to Be Referendum on Affirmative Action.

    Science.gov (United States)

    Manners, Bernadette

    1982-01-01

    Discusses the controversy that arose at Harvard Law School as a proposed course on civil rights and racial discrimination, to be taught by Black and White lawyers, led to a boycott movement by minority students who demanded more Black faculty members at the school.(MJL)

  2. "Young ladies are delicate plants": Jane Austen and Greenhouse Romanticism.

    Science.gov (United States)

    Lynch, Deidre Shauna

    2010-01-01

    By annotating how in Mansfield Park and Northanger Abbey Jane Austen tracks between the novelist's domain and the naturalist's, this essay seeks to unsettle some entrenched assumptions about her relationship to realism—and the ideological work of naturalization that realism is said to sponsor—as well as to romanticism. Austen's era, which we customarily identify as the time of a romantic return to nature, was marked by conflicts over what nature did and did not include—conflicts between, in the parlance of the period, "the botanist" and "the florist," between an account of nature as that which was given and an account of nature as that which (as with the modern nurseryman's new hybrids and luxuriants) might be manufactured. In arranging for her young heroines' stories of growing up to unfold in the "artificial climates" of modern fashionable gardening and amidst "florists' flowers," Austen deliberately works through those conflicts. She inhabits the plot of "natural development" to which she is often linked in elusively oppositional ways.

  3. Negative effect of discharging vinification lees on soils.

    Science.gov (United States)

    Moldes, Ana B; Vázquez, Manuel; Domínguez, José M; Díaz-Fierros, Francisco; Barral, María T

    2008-09-01

    In this work, vinification lees from Galicia (Spain) were chemically analysed and compared with the composition of vinification lees from other regions and residues. Moreover, vinification lees were submitted to biological test employing cress, spring barley and ryegrass seeds. The evaluated vinification lees were rich in nutrients that are essential for plants, like P (2,520 mg kg(-1)), K (36,738 mg kg(-1)) and Mg (462 mg kg(-1)), but have low pH (3.9) and high C/N ratio. However, when vinification lees were submitted to biological tests, no germination was observed for garden cress and ryegrass seeds and almost no germination for spring barley seeds, showing the negative effect of discharging lees on crop fields.

  4. Clumsy City by Design—A Theory for Jane Jacobs’ Imperfect Cities?

    Directory of Open Access Journals (Sweden)

    Sarah Maria Schmitt

    2016-12-01

    Full Text Available How do different concepts of justice correspond with the principles of diversity in cities introduced by Jane Jacobs? This contribution connects Jane Jacobs’ ideas on the diverse city with Mary Douglas’ Cultural Theory and its concept of clumsy solutions. According to Douglas’ Cultural Theory, every social situation can be described in terms of the four ideal-typical “rationalities”: individualism, egalitarianism, hierarchism, and fatalism. These four rationalities are again linked to different concepts of justice: libertarian, utilitarian, or social justice. Douglas’ Cultural Theory assumes that in every social situation all four of those rationalities emerge in some way and concludes that if a situation is not poly-rational, it is less robust. This opts for imperfect and “clumsy solutions”. It is argued that clumsy solutions, the four rationalities and related concepts fit Jane Jacobs’ claim for more diversity in urban design. This essentially calls for imperfect cities by design, ‘built’ by Jacobs’ generators for diversity. Although this outcome might not be revolutionary in the current debates about urban design, the concept of clumsy solutions provide a foundation for Jane Jacobs’ atheoretical claim for a diverse city. This contributes to new reflections on the urban planning paradigms of Jane Jacobs.

  5. Harvard Education Letter. Volume 27, Number 6, November-December 2011

    Science.gov (United States)

    Walser, Nancy, Ed.

    2011-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) With Cheating on the Rise, Schools Respond (David McKay Wilson); (2) Waldorf Education in Public Schools: Educators Adopt--and Adapt--This Developmental, Arts-Rich Approach…

  6. Harvard Education Letter. Volume 26, Number 1, January-February 2010

    Science.gov (United States)

    Chauncey, Caroline T., Ed.

    2010-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Charters and Unions: What's the Future for This Unorthodox Relationship? (Alexander Russo); (2) From Special Ed to Higher Ed: Transition Planning for Disabled Students Focuses…

  7. Harvard Education Letter. Volume 27, Number 3, May-June 2011

    Science.gov (United States)

    Chauncey, Caroline T., Ed.

    2011-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Bringing Art into School, Byte by Byte: Innovative Programs Use Technology to Expand Access to the Arts (Patti Hartigan); (2) Differentiated Instruction…

  8. Harvard Education Letter. Volume 26, Number 3, May-June 2010

    Science.gov (United States)

    Chauncey, Caroline T., Ed.

    2010-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Unleashing the "Brain Power" of Groups in the Classroom: The Neuroscience behind Collaborative Work (Nancy Walser); (2) Putting AP to the Test: New Research Assesses the…

  9. Harvard Education Letter. Volume 28, Number 2, March-April 2012

    Science.gov (United States)

    Chauncey, Caroline T., Ed.

    2012-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Course Credits on the Quick: Controversial Online Recovery Programs Speed the Path to Graduation (Andrew Brownstein); (2) Collaborating to Make Schools More Inclusive…

  10. Harvard Education Letter. Volume 28, Number 1, January-February 2012

    Science.gov (United States)

    Walser, Nancy, Ed.

    2012-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Using Theater to Teach Social Skills: Researchers Document Improvements for Children with Autism (Patti Hartigan); (2) The Family Model of Schooling Revisited: Few Teachers,…

  11. Harvard Education Letter. Volume 26, Number 2, March-April 2010

    Science.gov (United States)

    Chauncey, Caroline T., Ed.

    2010-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Online Testing, Version 1.0: Oregon's Adaptive Computer-Based Accountability Test Offers a Peek at a Brave New Future (Robert Rothman); (2) Beyond…

  12. Harvard Education Letter. Volume 27, Number 2, March-April 2011

    Science.gov (United States)

    Walser, Nancy, Ed.

    2011-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Hybrid Schools for the iGeneration: New Schools Combine "Bricks" and "Clicks" (Brigid Schulte); (2) Dual Language Programs on the Rise: "Enrichment" Model Puts Content Learning…

  13. Harvard Education Letter. Volume 26, Number 5, September-October 2010

    Science.gov (United States)

    Walser, Nancy, Ed.

    2010-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Scenes from the School Turnaround Movement: Passion, Frustration, Mid-Course Corrections Mark Rapid Reforms (Laura Pappano); (2) The Media Savvy Educator:…

  14. Harvard Education Letter. Volume 27, Number 5, September-October 2011

    Science.gov (United States)

    Chauncey, Caroline T., Ed.

    2011-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Teaching Students to Ask Their Own Questions: One Small Change Can Yield Big Results (Dan Rothstein and Luz Santana); (2) Voice of Experience: Jerry Weast--Leading a System…

  15. Harvard Education Letter. Volume 21, Number 6, November-December 2005

    Science.gov (United States)

    Chauncey, Caroline, Ed.

    2005-01-01

    "Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Is History... History?: Standards, Accountability, and the Future of Our Nation's Past (Robert Rothman); (2) Curriculum Access for All: How Teachers Can Use Universal Design…

  16. Applied Interventions in the Prevention and Treatment of Obesity Through the Research of Professor Jane Wardle.

    Science.gov (United States)

    Croker, Helen; Beeken, Rebecca J

    2017-03-01

    Obesity presents a challenge for practitioners, policy makers, researchers and for those with obesity themselves. This review focuses on psychological approaches to its management and prevention in children and adults. Through exploring the work of the late Professor Jane Wardle, we look at the earliest behavioural treatment approaches and how psychological theory has been used to develop more contemporary approaches, for example incorporating genetic feedback and habit formation theory into interventions. We also explore how Jane has challenged thinking about the causal pathways of obesity in relation to eating behaviour. Beyond academic work, Jane was an advocate of developing interventions which had real-world applications. Therefore, we discuss how she not only developed new interventions but also made these widely available and the charity that she established.

  17. On the Representations of Parent-Child Relationships in Jane Eyre by Charlotte Brontë

    Directory of Open Access Journals (Sweden)

    Alina PINTILII

    2014-12-01

    Full Text Available The paper aims at analysing the parent-child relationships in Charlotte Brontë’s novel Jane Eyre, with special emphasis on the relationship between Jane Eyre, the protagonist of the novel, and her aunt, Mrs. Reed. For this purpose, it begins by presenting the traits of the domestic Victorian ideal as well as those of the so-called “transnormative family”, to ultimately show that the Victorian domestic ideal was not valid for everyone, which had a great impact on both parents and children in the process of upbringing. Then, the paper considers the representations of Victorian domestic relationships in Charlotte Brontë’s Jane Eyre, which the author of the novel uses to demonstrate that a strong character and an iron will, like those of the protagonist, can make a difference and change destinies.

  18. Retrospective: Ivy Lee and the German Dye Trust.

    Science.gov (United States)

    Hainsworth, Brad E.

    1987-01-01

    Examines the relationship between public relations trailblazer Ivy Lee and the German Dye Trust, which became an agent for the policies of Adolf Hitler. Discusses how Lee's efforts to use this relationship to persuade his contacts to influence the Nazi leadership failed because of his formal connection with this group. (JD)

  19. Tim Berners-Lee and Kofi Annan during the WSIS

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  20. Tim Berners-Lee and Kofi Annan during the WSIS

    CERN Document Server

    Patrice Loïez

    2003-01-01

    During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee, W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  1. Complete synchronization of two Chen-Lee systems

    International Nuclear Information System (INIS)

    Sheu, L-J; Chen, J-H; Chen, H-K; Tam, L-M; Lao, S-K; Chen, W-C; Lin, K-T

    2008-01-01

    This study demonstrates that complete synchronization of two Chen-Lee chaotic systems can be easily achieved. The upper bound of the Chen-Lee chaotic system is estimated numerically. A controller is designed to synchronize two chaotic systems. Sufficient conditions for synchronization are obtained using Lyapunov's direct method. Two numerical examples are presented to verify the proposed synchronization approach

  2. Web Inventor Berners-Lee starts a Blog

    CERN Document Server

    Olson, Parmy

    2005-01-01

    Berners-Lee created what is known today as the World Wide Web. Now, just in time for the Web's 15th anniversary and after taking his proverbial stroll around the global dwelling of cyberspace, Berners-Lee is chatting with the rest of us about what he thinks with a blog

  3. Elegance in REBT: Reflections on the Ellis and Dryden Sessions with Jane

    OpenAIRE

    Dryden, Windy

    2010-01-01

    In this article, I reflect on the one-off sessions that Albert Ellis and I did with Jane. It is clear that Albert Ellis’s work is an example of inelegant or general REBT, while my session is an example of specific or elegant REBT. First, I speculate on the possible reasons why Ellis practised inelegant REBT is his session. Then, I critique my own work covering both what I like and dislike about my work with Jane. I conclude that while I practised elegant REBT with her, my work was\\ud flawed i...

  4. Tim Berners-Lee receives the Millennium Technology Prize

    CERN Multimedia

    2004-01-01

    On 15 April, for his invention of the Web, Tim Berners-Lee was awarded the first ever Millennium Technology Prize by the Finnish Technology Award Foundation, which recognises technological innovations of lasting benefit to society. "Tim Berners-Lee's invention perfectly encapsulates the spirit of the Prize. The Web is encouraging new types of social networks, contributing to transparency and democracy, and opening up new avenues for information management and business development," underlined Pekka Tarjanne, chairman of the jury and former Secretary-General of the International Telecommunication Union (ITU). Tim Berners-Lee is congratulated by Jukka Valtasaari, Finland's Ambassador to the United States. Tim Berners-Lee created the first server, browser and editor, the HTML code, the URL address and the HTTP transmission protocol at CERN in 1990. CERN released the Web into the public domain in 1993. Tim Berners-Lee is currently head of the World Wide Web Consortium, managed by ERCIM (Europe...

  5. Jane Eyre : un roman innovant pour les critiques victoriens Jane Eyre: an Innovating Novel according to the Victorian Critics

    Directory of Open Access Journals (Sweden)

    Odile Boucher-Rivalain

    2009-07-01

    Full Text Available After the failure to publish her first novel The Professor Charlotte Brontë wrote her second work of fiction Jane Eyre in a conscious effort to satisfy the critics’ expectations, combining the more traditional elements of novel-writing with more innovating ones suggested by her own imagination. An examination of the reviews which appeared in the months following the publication of Jane Eyre reveals Charlotte Brontë’s strategy: her choice of an unconventional relationship between the poor, plain governess and her wealthy, passionate master, the exploration of her heroine’s interior life combined with the realistic descriptions of her characters’ physical and social environment. This combination ensured the success of the novel which was overwhelmingly praised for its innovative elements even if the more conservative critics disapproved of such novelties.

  6. Loi et identité féminine dans Jane Eyre. Lecture psychocritique The Making of Feminine Identity and Law in Jane Eyre. A Psychocritical Reading

    Directory of Open Access Journals (Sweden)

    Max Vega-Ritter

    2009-07-01

    Full Text Available This article seeks to throw light on a pattern of undercurrents within Jane Eyre probably originating from the network of relations to the father or (dead mother figure—or their substitutes—within the closely knit Brontë phratry. It will endeavour to reveal the “son / daughter figure as usurping favourite / and / or / deprived victim” as a hidden “Freudian phantasy” which seems to operate in and organise, Wuthering Heights and some of the Brontës’ Juvenilia as well. A masochistic relationship with the father figure is traced and seen to develop on lines similar to Sigmund Freud’s analysis in “A Child is being beaten”. This study proceeds on to describe the way Jane Eyre gives shape to a new, more feminine sense of authority based on her experience at Lowood and on the moral and spiritual values her identifying with Helen Burns and Miss Temple instilled in her. She builds on them in an effort to stand up to Rochester’s claim to assert his power as a father figure and to bend her to his will until Mason discloses his transgression of Law. By rising to meet Rochester’s challenge, Jane is forced to affirm her own will and her capacity for mastering “her master”. Lucy Snowe in Villette and Shirley Keeldar in Shirley go through a similar experience. Thus Bertha Rochester emerges as the archetype of a feminine power both dreaded and reproved. Far from being Jane’s repressed mirror image, she serves to protect and exonerate her from any charge of resentful anger against Man’s power. Indeed Jane is constantly shown to accommodate a traditional feminine surrender to Love and a firm stand as a Law figure with regard to a masculine partner who uses Law as a means towards the pursuit of Power. Eventually the two characters femininise and / or virilise each other.

  7. Thermodynamics of the Lee-Wick partners: An alternative approach

    International Nuclear Information System (INIS)

    Bhattacharya, Kaushik; Das, Suratna

    2011-01-01

    It was pointed out some time ago that there can be two variations in which the divergences of a quantum field theory can be tamed using the ideas presented by Lee and Wick. In one variation the Lee-Wick partners of the normal fields live in an indefinite metric Hilbert space but have positive energy and in the other variation the Lee-Wick partners can live in a normal Hilbert space but carry negative energy. Quantum mechanically the two variations mainly differ in the way the fields are quantized. In this article the second variation of Lee and Wick's idea is discussed. Using statistical mechanical methods the energy density, pressure and entropy density of the negative energy Lee-Wick fields have been calculated. The results exactly match with the thermodynamic results of the conventional, positive energy Lee-Wick fields. The result sheds some light on the second variation of Lee-Wick's idea. The result seems to say that the thermodynamics of the theories do not care about the way they are quantized.

  8. Jane Fonda võitis Cannes'is eriauhinna / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2007-01-01

    Cannes'i filmifestivalil jagati auhindu. Ameerika näitleja Jane Fonda sai elutöö auhinna, Kuldse Palmioksa sai rumeenlase Christian Mungiu "Neli kuud, kolm nädalat ja kaks päeva". Ka programmi "Vaatenurk" auhindadest

  9. Pedagogical Discourses of Gender, Peace, and Equality: Jane Addams Children's Book Awards

    Science.gov (United States)

    Taber, Nancy

    2015-01-01

    This article discusses a feminist critical discourse analysis research project of award-winning books of the Jane Addams Peace Association. Children's books carry societal messages that are gendered, raced, and classed, with award-winning books carrying an additional message of exceptionality as they are viewed as deserving of attention.…

  10. Readings on Jane Austen. The Greenhaven Press Literary Companion to British Authors.

    Science.gov (United States)

    Swisher, Clarice, Ed.

    Designed for young adults, this book on Jane Austen's novels is one of an anthology series providing accessible resources for students researching great literary lives and works. Contributing writers' essays in the book are taken from a wide variety of sources and are edited to accommodate the reading and comprehension levels of young adults; each…

  11. Jane Austen's Novels as a Guide to Social and Individual Responsibility for High School Students.

    Science.gov (United States)

    Fritzer, Penelope

    1998-01-01

    Jane Austen's novels are particularly appropriate for adolescents. These classics deal with topics of high interest to young people. Austen grapples with the question of what the individual owes to society and what he or she is obliged to tolerate in the way of strictures on behavior. Article proposes that Austen's novels should be more widely…

  12. A Female Interrogative Reader: The Adolescent Jane Austen Reads and Rewrites (His)tory.

    Science.gov (United States)

    Reid-Walsh, Jacqueline

    1992-01-01

    Argues that Jane Austen's unpublished juvenile work "The History of England" has considerable relevance to twentieth-century high-school English classrooms. Notes that the work humorously shows the gender bias of traditional history texts because it is a "woman-centered" rewriting. (RS)

  13. Putting the Pieces Together: Using Jane Smiley's "A Thousand Acres" in Sociology of Families.

    Science.gov (United States)

    Hall, Kelley J.

    2000-01-01

    Addresses the use of fiction to teach undergraduate students about sociological theories and concepts. Discusses how "A Thousand Acres" (Jane Smiley) was used in a sociology of families course. Includes descriptions of the plot and themes in the book and the group work and paper assigned in conjunction with Smiley's novel. (CMK)

  14. The book and reading in the space of performance: the case of Jane Austen Book Club

    Directory of Open Access Journals (Sweden)

    Carmen Irene Correa de Oliveira

    2012-05-01

    Full Text Available We propose to discuss the role of filmic narratives with the book as an object of representation in the context of the imaginary of shapes and types of knowledge, of ways of reading organization and of practices that have the book as object. Finally, we have the dialogical perspective of the works, its time, the subject readers and its context. For this project, we bring the filmic text The Jane Austen Book Club (2007, based on a book (The Jane Austen book club by Karen Joy Fowler, which focuses on personal and intimate dramas from people at different times of sharing, unfolding for six months, and that presents individual experiences which are mixed with the characters’ plots from the books of the English author. We highlight in the film, book and reading as narrative elements, characters accomplices of small dramas. In The Jane Austen Book Club, we perform an extrapolation in order to put the two moments - the performance and reading - in the practices developed by the participants of the club. They find the work of Austen in individual reading and in the performance that puts everyone in a continuous space of action and transformation. We believe, finally, that individual reading and the club meetings make it possible to think of the reception (individual reading and performance (reading/collective analysis in a combination that allows a constant revitalization of the work, in the case of Jane Austen.

  15. Harvard College Observatory: Shapley's Factory for PhD Degrees?

    Science.gov (United States)

    Welther, B. L.

    2000-12-01

    When Harlow Shapley assumed the Directorship of Harvard College Observatory in 1921, there was no program in place there to train the next generation of astronomers. In 1923, using the Pickering Fund for women assistants, Shapley hired a young English woman, Cecilia Payne, to work on stellar spectra. Just two short years later, Payne completed her research and wrote a celebrated thesis on stellar atmospheres. Because Harvard University was not prepared to confer a PhD degree on a woman at that time, Payne presented her thesis to Radcliffe College. Thus, in 1925 she became the first person to receive a PhD in astronomy for a research project at HCO. By 1933, a PhD in Astronomy had been conferred on eight graduate students who had undertaken research projects at HCO: four men who received their degree from Harvard, and four women, from Radcliffe. In subsequent years, however, the equal distribution of degrees for men and women quickly changed. When the 30th degree was bestowed in 1943, only 10 of the candidates were women. By 1955, when the 60th degree was conferred, only 14 women had received a PhD. In just two decades, then, the ratio of women astronomers had steadily dropped from a solid 50% at the height of the Shapley era to slightly less than 25% at his retirement. Also, until the mid-1960s, the women astronomers still had to apply to Radcliffe for their PhD degrees. This paper will briefly examine the funding and research topics of some of the HCO PhD candidates in the Shapley Era (1921-1955). It will also highlight some of their subsequent contributions to 20th-century American Astronomy.

  16. Constraints on the Lee-Wick Higgs sector

    International Nuclear Information System (INIS)

    Carone, Christopher D.; Primulando, Reinard

    2009-01-01

    Lee-Wick partners to the standard model Higgs doublet may appear at a mass scale that is significantly lower than that of the remaining Lee-Wick partner states. The relevant effective theory is a two-Higgs doublet model in which one doublet has wrong-sign kinetic and mass terms. We determine bounds on this effective theory, including those from neutral B-meson mixing, b→X s γ, and Z→bb. The results differ from those of conventional two-Higgs doublet models and lead to meaningful constraints on the Lee-Wick Higgs sector.

  17. Jane Cooke Wright (1919-2013): Pioneering oncologist, woman and humanitarian.

    Science.gov (United States)

    Crosby, Harriet L

    2016-02-01

    Jane Wright was a fundamental researcher in cancer chemotherapy in the 1950s-1980s and was one of the first scientists to test anti-cancer drugs on humans rather than solely on mice, discovering the use of the popular antimetabolite drug methotrexate on solid tumours. From her research she was able to conclude which specific anti-cancer agents would have the greatest lethal effect on a patient's certain cancer type and she invented a method of delivering chemotherapy agents directly to an internal cancer site. During a time when the Civil Rights in the United States of America were undergoing a transformation to reduce the discrimination and segregation imposed on African Americans and the civil rights activist Martin Luther King Jr made a speech to call for an end to racism in 1963, Jane Wright became the first African American to hold such a high position at a nationally recognised institution and the first woman to be elected President of the New York Cancer Society. US President Lyndon B Johnson appointed Jane to the President's Commission of Heart Disease, Cancer and Stroke (serving 1964-1965) and the National Cancer Advisory Board (serving 1966-1970). Jane retired in 1987 by which time she had published more than 75 scientific papers, led delegations of oncologists in China, the former Soviet Union, Africa and Europe and held key positions in various international and national organisations. Jane Wright passed away on 19 February 2013 aged 93 but her legacy lives on in the name of an award from the American Association of Cancer Research. © The Author(s) 2014.

  18. General Robert E. Lee -- Brightest Star in the South

    National Research Council Canada - National Science Library

    Dalton, Kent B

    2006-01-01

    .... Lee's distinctive application of operational art and leadership as the commander of the Army of Northern Virginia, we can discern many lessons which are still pertinent to our commanders at the operational level today...

  19. The Statecraft of Lee Kuan Yew, Visionary and Opportunist

    National Research Council Canada - National Science Library

    Thomas, David

    1996-01-01

    ...." "Not so," replied the passenger, Lee Kuan Yew, "Singapore intends to continue to ride along as part of the federation created with Malaysia, Sarawak, and Sabah -- we have no plans for getting off...

  20. Nobel laureate T.D. Lee at CERN

    CERN Multimedia

    2007-01-01

    On 30 August, Professor T.D. Lee, who received the Nobel Prize for Physics in 1957, gave a seminar at CERN on symmetry and asymmetry in electroweak interactions, 50 years after the discovery of the non-conservation of parity. In 1956, Tsung-Dao Lee postulated with Chen Ning Yang that parity is not conserved in weak interactions, and suggested several experiments to demonstrate this. The following year, an experiment led by Chien-Shiung Wu proved this prediction and, soon after, T.D. Lee and Chen Ning Yang were awarded the Nobel Prize for Physics. Still very active at over 80 years of age, T.D. Lee pursues his theory work to this day.

  1. Adèle, version abâtardie de Jane Eyre Adèle, an “Addled” Version of Jane Eyre?

    Directory of Open Access Journals (Sweden)

    Claire Bazin

    2009-10-01

    Full Text Available Adèle is a rewriting of the story of Jane Eyre published 150 years before. Emma Tennant, who is a specialist in the field of « revisions » puts Adèle, Jane’s young pupil in the Ur-text, in the limelight by giving her a « story  of her own », as if she were taking her revenge on the original text which had given her so insignificant a part.

  2. Teater vajab ellujäämiseks värsket dramaturgiat / Jane Rasch ; vahendanud Eva-Liisa Linder

    Index Scriptorium Estoniae

    Rasch, Jane

    2009-01-01

    Taani teatriteadlane Jane Rasch õpetas 10.-14. augustini 2009 Viljandi Kultuuriakadeemias toimunud draamakirjutuskursusel "Ideedest näidendi stsenaariumini". Ka näitekirjanike koolitamisest Taanis jt. Põhjamaades

  3. Did the "Woman in the Attic" in Jane Eyre Have Huntington Disease?

    Science.gov (United States)

    Coon, Elizabeth A; Hassan, Anhar

    2015-01-01

    References to neurologic disorders are frequently found in fictional literature and may precede description in the medical literature. Our aim was to compare Charlotte Brontë's depiction of Bertha Mason in Jane Eyre to the tenets set forth in George Huntington's original essay "On chorea" with the hypothesis that Mason was displaying features of Huntington disease. Charlotte Brontë's 1847 Victorian novel Jane Eyre features the character Bertha Mason, who is portrayed with a progressive psychiatric illness, violent movements, and possible cognitive decline. Similar to Huntington's tenets, Mason has a disorder with a strong family history suggestive of autosomal dominant inheritance with onset in adulthood, and culminating in suicide. Brontë's character had features of Huntington disease as originally described by Huntington. Brontë's keen characterization may have increased awareness of treatment of neuropsychiatric patients in the Victorian era.

  4. The Distribution and Frequency of the Terms "Pride" and "Prejudice" in Jane Austen's Pride and Prejudice

    Directory of Open Access Journals (Sweden)

    Tanja Dromnes

    2009-03-01

    Full Text Available In this article we examine the title terms of Jane Austen's Pride and Prejudice (1813 with particular attention to their distribution and frequency in the text. Our method is to connect the statistical material gathered on frequency and distribution to a narratological analysis of the terms, with special emphasis on whether they occur within the focalization of the external narrator, or that of character-focalizers. In order to approach this task, we have availed ourselves of the narratological theories of Mieke Bal. We conclude that there is a differentiation among types of focalization in the novel that enhances the thematic structure of match-making. Although Jane Austen wrote and published her major works two centuries ago, they continue to fascinate literary scholars and general readers alike.

  5. Seeking Austen, from Abroad: Lori Smith’s Memoir 'A Walk with Jane Austen' (2007

    Directory of Open Access Journals (Sweden)

    Juliette Wells

    2009-05-01

    Full Text Available One outcome of Jane Austen’s popularity with present-day readers is their creation of books derived from and inspired by her own. This article examines a recent contribution to this increasingly crowded field: Lori Smith’s 2007 'A Walk with Jane Austen: A Journey into Adventure, Love & Faith', which depicts a thirtysomething American woman’s travel to England in the hopes of better understanding both Austen and herself. I consider this memoir in relation to other works created by Austen fans, including those who, like Smith, aim primarily at a Christian readership; I address as well this book’s significance as an account of literary pilgrimage and of personally transformative reading.

  6. ‘Gaze’ and ‘Visuality’ in Jane Austen’s Pride and Prejudice

    Directory of Open Access Journals (Sweden)

    Zolfagharkhani M.

    2012-01-01

    Full Text Available For many readers, there is no connection between Jane Austen’s novels and the sexualized body. Sexuality in Austen’s novels is never explicit; nonetheless, it permeates every look, gesture, and letter that passes between her lovers. This article aims to reveal the concept of ‘gaze’, especially female gaze, in Jane Austen’s Pride and Prejudice. According to feminist critics it is psychologically inevitable that women are the sexual objects of men; therefore, they have effectively refused to acknowledge the possibility that a female gaze could exist. Arguably, as it is indicated throughout this article, women are not necessarily rendered mute and inert by the male gaze; in fact, they actively shape and respond to male desire and their gaze encompasses as much authority and power as the male gaze.

  7. Applied Interventions in the Prevention and Treatment of Obesity Through the Research of Professor Jane Wardle

    OpenAIRE

    Croker, Helen; Beeken, Rebecca J.

    2017-01-01

    Purpose of Review Obesity presents a challenge for practitioners, policy makers, researchers and for those with obesity themselves. This review focuses on psychological approaches to its management and prevention in children and adults. Recent Findings Through exploring the work of the late Professor Jane Wardle, we look at the earliest behavioural treatment approaches and how psychological theory has been used to develop more contemporary approaches, for example incorporating genetic feedbac...

  8. The Exploration of human experience in Jane Austen's Northanger Abbey

    OpenAIRE

    Mulas, Francesco Gesuino

    2005-01-01

    Jane Austen's purpose in Northanger Abbey, both in her aesthetic principles and moral intents, is to explore the human experience in its fullest sense. How do people perceive and understand themselves and each other? What are they like and how can they learn and grow? If moral problems are a question of thought rather than of action, as a consequence to ask what characters are like is also to ask what an author's conception of them should be.

  9. Jane Austen (1775-1817) and the cultural history of health.

    Science.gov (United States)

    Biddiss, Michael

    2014-08-01

    This paper provides a review of some aspects of the life and novels of Jane Austen that have particular bearing on her approach to issues of sickness and health. It is based on a Keynote Lecture given at the Annual Congress of the British Society for the History of Medicine on 1 September 2011 at the University of Surrey. © IMechE 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  10. 77 FR 46120 - Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard University...

    Science.gov (United States)

    2012-08-02

    ...-1100-665] Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard... objects in the possession of the Peabody Museum of Archaeology and Ethnology, Harvard University..., officials of the Peabody Museum of Archaeology and Ethnology have determined that there is a relationship of...

  11. 75 FR 58431 - Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard University...

    Science.gov (United States)

    2010-09-24

    ... National Park Service Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard... Peabody Museum of Archaeology and Ethnology, Harvard University, Cambridge, MA. The human remains were... paragraph: Officials of the Peabody Museum of Archaeology and Ethnology have determined that, pursuant to 25...

  12. 75 FR 33328 - Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard University...

    Science.gov (United States)

    2010-06-11

    ... National Park Service Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard... objects in the possession of the Peabody Museum of Archaeology and Ethnology, Harvard University... Archaeology and Ethnology by the Hingham Board of Health through Secretary Mayo Tolman in the same year. No...

  13. Much Ado about Something? James Bryant Conant, Harvard University, and Nazi Germany in the 1930s

    Science.gov (United States)

    Urban, Wayne J.; Smith, Marybeth

    2015-01-01

    This paper discusses the actions of noted Harvard University president James Bryant Conant, taken in regard to the Nazi government in Germany, from the time of Conant's becoming president of Harvard University in 1933 to the time of the widespread pogrom in Germany of 9-10 November 1938, known as Kristallnacht. Conant's attitudes and actions…

  14. Captation spéculaire et mise en abyme dans le film Jane Eyre de Franco Zeffirelli Specular Captation and Metafictional Devices in Zeffirelli’s Jane Eyre

    Directory of Open Access Journals (Sweden)

    Isabelle Van Peteghem-Tréard

    2009-07-01

    Full Text Available This article presents Franco Zeffirelli’s baroque use of mirrors to evoke the specular alienation of Jane Eyre who is both the heroine and the story-teller in the movie and in the original text. The mirror image—or, condensed into a single word, the “mirage”—is not only whole and non-human as opposed to fragmented, turbulent and human, it is an “exteriority,” an outside that is also inside. The ego experiences a perpetual rift that is modeled on the subject’s dual relations with its specular counterpart, the other woman. The mirror stage presents through dramatic exemplification a certain level of rupture between inwardly lived and external realities. The director thus emphasizes the question of representation and its various metafictional modes as Jane Eyre—the movie— can be seen as a portrait of the artist. Drawing can be regarded as the cinematic equivalent of narration in Charlotte Brontë’s work and also as empowerment for the female subject who ultimately becomes a creator.

  15. Translating Jane Austen’s Mansfield Park for contemporary Italian readers

    Directory of Open Access Journals (Sweden)

    Simona Sangiorgi

    2015-12-01

    Full Text Available Abstract - My Italian translation of the novel Mansfield Park by Jane Austen was published by Rusconi Libri in 2012. The present contribution aims to describe and discuss some aspects of my practical experience in translating this novel. A particular focus will be on the issue of what it means, from both the cultural and the literary point of view, to translate this book into Italian in the 21st century, and on the strategies I adopted in order to translate certain aspects of the author’s language and style. Riassunto - Nel 2012 è stata pubblicata la mia traduzione in lingua italiana del romanzo Mansfield Park di Jane Austen. Il presente contributo intende osservare e discutere alcuni elementi culturali e linguistici legati al processo traduttivo di questo testo, con particolare riferimento a due principali questioni. La prima riguarda il significato stesso del tradurre in lingua italiana l’opera di Jane Austen nel ventunesimo secolo, sia dal punto di vista culturale che letterario. La seconda questione entra nel merito delle strategie traduttive che ho scelto per rendere specifici aspetti del linguaggio e dello stile propri dell’autrice inglese.

  16. Radiation bounce from the Lee-Wick construction?

    International Nuclear Information System (INIS)

    Karouby, Johanna; Brandenberger, Robert

    2010-01-01

    It was recently realized that matter modeled by the scalar field sector of the Lee-Wick standard model yields, in the context of a homogeneous and isotropic cosmological background, a bouncing cosmology. However, bouncing cosmologies induced by pressureless matter are in general unstable to the addition of relativistic matter (i.e. radiation). Here we study the possibility of obtaining a bouncing cosmology if we add not only radiation, but also its Lee-Wick partner, to the matter sector. We find that, in general, no bounce occurs. The only way to obtain a bounce is to choose initial conditions with very special phases of the radiation field and its Lee-Wick partner.

  17. Lee Acculturation Dream Scale for Korean-American college students.

    Science.gov (United States)

    Lee, Sang Bok

    2005-04-01

    This study examined acculturation as represented in dream narratives of 165 Korean immigrant college students living in the USA. A total of 165 dreams were collected and evaluated using the Lee Acculturation Dream Scale, for which locations of dream contents were coded. 39% of the dreams took place in South Korea, while 38% were in the USA. Also, 16% of the dreams included both locations, whereas 7% had no specific dream location. The dreams contained overlapping dream messages, images, scenes, and interactions in both South Korea and the USA. A two-sample t test on the mean scores of the Lee Acculturation Dream Scale indicated no significant difference between men and women.

  18. Lee-Wick indefinite metric quantization: A functional integral approach

    International Nuclear Information System (INIS)

    Boulware, D.G.; Gross, D.J.

    1984-01-01

    In an attempt to study the stability of the Lee-Wick indefinite metric theory, the functional integral for indefinite metric quantum field theories is derived. Theories with an indefinite classical energy may be quantized with either a normal metric and an indefinite energy in Minkowski space or an indefinite metric and a positive energy in euclidean space. However, the functional integral in the latter formulation does not incorporate the Lee-Wick prescription for assuring the unitarity of the positive energy positive metric sector of the theory, hence the stability of the theory cannot be studied non-perturbatively. (orig.)

  19. Alliances in Human Biology: The Harvard Committee on Industrial Physiology, 1929-1939.

    Science.gov (United States)

    Oakes, Jason

    2015-08-01

    In 1929 the newly-reorganized Rockefeller Foundation funded the work of a cross-disciplinary group at Harvard University called the Committee on Industrial Physiology (CIP). The committee's research and pedagogical work was oriented towards different things for different members of the alliance. The CIP program included a research component in the Harvard Fatigue Laboratory and Elton May's interpretation of the Hawthorne Studies; a pedagogical aspect as part of Wallace Donham's curriculum for Harvard Business School; and Lawrence Henderson's work with the Harvard Pareto Circle, his course Sociology 23, and the Harvard Society of Fellows. The key actors within the CIP alliance shared a concern with training men for elite careers in government service, business leadership, and academic prominence. But the first communications between the CIP and the Rockefeller Foundation did not emphasize training in human biology. Instead, the CIP presented itself as a coordinating body that would be able to organize all the varied work going on at Harvard that did not fit easily into one department, and it was on this basis that the CIP became legible to the President of Harvard, A. Lawrence Lowell, and to Rockefeller's Division of Social Sciences. The members of the CIP alliance used the term human biology for this project of research, training and institutional coordination.

  20. Tropical veterinary parasites at Harvard University's Museum of Comparative Zoology.

    Science.gov (United States)

    Conn, David Bruce

    2008-12-01

    Tropical veterinary parasites have been maintained by the Museum of Comparative Zoology (MCZ) at Harvard University since the mid 1800s. Most of these are maintained by the Department of Invertebrate Zoology, but many vectors and intermediate hosts are maintained by the Departments of Entomology and Malacology. The largest collections are of avian and mammalian ticks (Acarina) that are important as both parasites and vectors. Nematodes are second in numbers, followed by cestodes, trematodes, and several minor helminth groups, crustacean parasites of fish, and protozoan parasites of various hosts. The MCZ directed or participated in several major expeditions to tropical areas around the globe in the early 1900s. Many of these expeditions focused on human parasites, but hundreds of veterinary and zoonotic parasites were also collected from these and numerous, smaller, tropical expeditions. Host sources include companion animals, livestock, laboratory species, domestic fowl, reptiles, amphibians, exotics/zoo animals, commercially important fishes, and other wildlife. Specimens are curated, either fixed whole in vials or mounted on slides as whole mounts or histopathological sections. The primary emphasis of MCZ's current work with tropical veterinary parasites is on voucher specimens from epidemiological, experimental, and clinical research.

  1. Lee de Forest King of Radio, Television, and Film

    CERN Document Server

    Adams, Mike

    2012-01-01

    Lee de Forest, Yale doctorate and Oscar winner, gave voice to the radio and the motion picture. Yet by the 1930s, after the radio and the Talkies were regular features of American life, Lee de Forest had seemingly lost everything. Why? Why didn’t he receive the recognition and acclaim he sought his entire life until years later in 1959, when he was awarded an Oscar? A lifelong innovator, Lee de Forest invented the three-element vacuum tube which he developed between 1906 and 1916 as a detector, amplifier, and oscillator of radio waves. As early as 1907, he was broadcasting music programming. In 1918, he began to develop a system for recording and playing back sound by using light patterns on motion picture film. In order to promote and demonstrate his process he made hundreds of short sound films, found theatres for their showing, and issued publicity to gain audiences for his invention. While he received many patents for this technology, he was ignored by the film industry. Lee de Forest, King of Radio, Te...

  2. Must Historians Regress? An Answer to Lee Benson.

    Science.gov (United States)

    Kousser, J. Morgan

    1986-01-01

    Considers the impact of empirical social science methodology and data analysis techniques on the process of historical analysis and its product, generalizations about the past. Uses political preference and voting information as a vehicle to illustrate the differences in historical conclusions reached by Lee Benson and J. Morgan Kousser. (JDH)

  3. The Garrett Lee Smith Memorial Suicide Prevention Program

    Science.gov (United States)

    Goldston, David B.; Walrath, Christine M.; McKeon, Richard; Puddy, Richard W.; Lubell, Keri M.; Potter, Lloyd B.; Rodi, Michael S.

    2010-01-01

    In response to calls for greater efforts to reduce youth suicide, the Garrett Lee Smith (GLS) Memorial Act has provided funding for 68 state, territory, and tribal community grants, and 74 college campus grants for suicide prevention efforts. Suicide prevention activities supported by GLS grantees have included education, training programs…

  4. Sieve bootstrapping in the Lee-Carter model

    NARCIS (Netherlands)

    Heinemann, A.

    2013-01-01

    This paper studies an alternative approach to construct confidence intervals for parameter estimates of the Lee-Carter model. First, the procedure of obtaining confidence intervals using regular nonparametric i.i.d. bootstrap is specified. Empirical evidence seems to invalidate this approach as it

  5. Robert E. Lee, George Peabody, and Sectional Reunion.

    Science.gov (United States)

    Parker, Franklin

    1994-01-01

    Discusses an 1869 meeting between George Peabody, educational philanthropist, and Robert E. Lee. The meeting focused public attention on the Peabody Education Fund and the South's educational plight. Significant measures of educational efforts in the South are directly attributable to several informal meetings centered around Peabody and Lee…

  6. Rejoinder to Goldberg, Lee and Ashton : Explaining counterintuitive findings

    NARCIS (Netherlands)

    Anderson, N.; Ones, D.S.

    2008-01-01

    In their critique of our erratum and addendum (Anderson & Ones, [2008]), Goldberg, Lee, and Ashton ([2008]) allege clerical errors (1) where participants' HPI scores were incorrectly matched to other inventory scale scores and (2) in scoring of the OPQ and BPI scales. The first point was fully

  7. W3C head Berners-Lee to be knighted

    CERN Multimedia

    Gross, G

    2004-01-01

    "Tim Berners-Lee, credited with inventing the World Wide Web and now director of the World Wide Web Consortium, will be named a knight commander, Order of the British Empire, by Queen Elizabeth II, the W3C announced Wednesday" (1 page)

  8. Virginia Lee Burton's "Little House" in Popular Consciousness

    DEFF Research Database (Denmark)

    Goddard, Joseph

    2011-01-01

    This article considers the significance of Victoria Lee Burton’s authorship, specifically The Little House, for lifestyle preferences and the development of environmental consciousness in the postwar period. The article argues that Burton deliberately designed her work to evoke country-friendly s...

  9. Berners-Lee wins inaugural Millennium Technology prize

    CERN Multimedia

    2004-01-01

    "World Wide Web inventor Tim Berners-Lee today was named recipient of the first-ever Millennium Technology Prize. The honor, which is accompanied by one million euros, is bestowed by the Finnish Technology Award Foundation as an international acknowledgement of outstanding technological innovation aimed at promoting quality of life and sustainable economic and societal development" (1 page)

  10. Tim Berners-Lee, World Wide Web inventor

    CERN Document Server

    1998-01-01

    The "Internet, Web, What's next?" conference on 26 June 1998 at CERN: Tim Berners-Lee, inventor of the World Wide Web and Director of the W3C, explains how the Web came to be and gave his views on the future.

  11. Dan Gilmor Column [Berners-Lee and the WWW

    CERN Multimedia

    Gillmore, D

    2002-01-01

    In the keynote speech at the 11th Annual World Wide Web Conference, Tim Berner's Lee said that in the early days of the web, people were worrying about the same thing as today - one company dominating the market and controlling standards (2 pages).

  12. At Home with Jane Austen: Imagining the Colonial Connection in Mansfield Park

    Directory of Open Access Journals (Sweden)

    Blanka Grzegorczyk

    2009-11-01

    Full Text Available This article examines Jane Austen's Mansfield Park in the context of the complex relationship between imaginative literature and the experience of empire. Specifically, it argues that the way Austen's novel plays with the imperial experience is more ambivalent than many critics have indicated. It suggests that underlying the imaginative conceptualization of the relations between metropole and colony are certain evasions and contradictions in which the novel consciously abounds. A close reading of the novel demonstrates how issues related to metropole and colony may be articulated within the literary mainstream, and why such narrative articulation is important.

  13. J. M. Gratale on Jane Chapman’s Issues in Contemporary Documentary

    Directory of Open Access Journals (Sweden)

    2010-03-01

    Full Text Available Jane Chapman, Issues in Contemporary Documentary.  Polity Press, 2009.  pp.  210 ISBN:  978-0-7456-4009-9.The prevalence of images in contemporary society and culture is a patent reality.  From digital photography to cinematic film, and cell phone imaging to You Tube, the production and circulation of the image is becoming more and more diffused. In conjunction with such developments is the fact that the mediums and technologies which ‘deliver’ these images are constantly diversifying and imp...

  14. Jane Kelsey, Serving Whose Interests? The Political Economy of Trade in Services Agreements

    Directory of Open Access Journals (Sweden)

    Maureen Irish

    2009-02-01

    Full Text Available Serving Whose Interests is an examination of the General Agreement on Trade in Services [GATS] since its inception in 1995, with several case studies that discuss services trade in specific applications around the world. The scholarship i s extensive and detailed. Jane Kelsey, law professor at the University of Auckland, has criticized the pro-market services trade regime i n her role as a political activist. In this book, her goals are to make the technicalities of trade rules accessible and to show their effects on people and communities.

  15. Mobilidade social em Orgulho e preconceito, de Jane Austen, e Senhora, de Jos? de Alencar

    OpenAIRE

    Silva, M?rcio Azevedo da

    2015-01-01

    A proposta desta disserta??o ? promover um di?logo, a partir da Literatura Comparada, sobre mobilidade social nos romances Orgulho e Preconceito, da escritora inglesa, Jane Austen, e Senhora, do escritor brasileiro Jos? de Alencar. Cada romance ? de extrema relev?ncia para a compreens?o das sociedades inglesa e brasileira do per?odo em que os livros foram escritos. No primeiro cap?tulo, apresentamos o contexto hist?rico em que os autores est?o inseridos, considerando a influ?ncia da era Georg...

  16. ISLSCP II Carbon Dioxide Flux at Harvard Forest and Northern BOREAS Sites

    Data.gov (United States)

    National Aeronautics and Space Administration — Carbon dioxide flux and meteorological data for the Harvard Forest, MA (1992-95) and BOREAS Northern Study Area, Old Black Spruce (Alberta, Canada; 1994-95) FLUXNET...

  17. ISLSCP II Carbon Dioxide Flux at Harvard Forest and Northern BOREAS Sites

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: Carbon dioxide flux and meteorological data for the Harvard Forest, MA (1992-95) and BOREAS Northern Study Area, Old Black Spruce (Alberta, Canada;...

  18. Nooruslikud juubilarid: fotokelder Lee 20 ja fotomuuseum 30 / Mall Parmas, Betty Ester-Väljaots

    Index Scriptorium Estoniae

    Parmas, Mall

    2013-01-01

    Peeter Toominga algatusel 1992. aastal asutatud Lee fotokeldrist. Loetletud fotomuuseumis oma töid eksponeerinud fotograafid. Ülevaatenäitus "Lee fotokelder 20" 17. jaanuarist 20. märtsini, koostaja Betty Ester-Väljaots

  19. Optimizing Frozen Sample Preparation for Laser Microdissection: Assessment of CryoJane Tape-Transfer System®.

    Directory of Open Access Journals (Sweden)

    Yelena G Golubeva

    Full Text Available Laser microdissection is an invaluable tool in medical research that facilitates collecting specific cell populations for molecular analysis. Diversity of research targets (e.g., cancerous and precancerous lesions in clinical and animal research, cell pellets, rodent embryos, etc. and varied scientific objectives, however, present challenges toward establishing standard laser microdissection protocols. Sample preparation is crucial for quality RNA, DNA and protein retrieval, where it often determines the feasibility of a laser microdissection project. The majority of microdissection studies in clinical and animal model research are conducted on frozen tissues containing native nucleic acids, unmodified by fixation. However, the variable morphological quality of frozen sections from tissues containing fat, collagen or delicate cell structures can limit or prevent successful harvest of the desired cell population via laser dissection. The CryoJane Tape-Transfer System®, a commercial device that improves cryosectioning outcomes on glass slides has been reported superior for slide preparation and isolation of high quality osteocyte RNA (frozen bone during laser dissection. Considering the reported advantages of CryoJane for laser dissection on glass slides, we asked whether the system could also work with the plastic membrane slides used by UV laser based microdissection instruments, as these are better suited for collection of larger target areas. In an attempt to optimize laser microdissection slide preparation for tissues of different RNA stability and cryosectioning difficulty, we evaluated the CryoJane system for use with both glass (laser capture microdissection and membrane (laser cutting microdissection slides. We have established a sample preparation protocol for glass and membrane slides including manual coating of membrane slides with CryoJane solutions, cryosectioning, slide staining and dissection procedure, lysis and RNA extraction

  20. Vafa-Witten theorem and Lee-Yang singularities

    International Nuclear Information System (INIS)

    Aguado, M.; Asorey, M.

    2009-01-01

    We prove the analyticity of the finite volume QCD partition function for complex values of the θ-vacuum parameter. The absence of singularities different from Lee-Yang zeros only permits and cusp singularities in the vacuum energy density and never or cusps. This fact together with the Vafa-Witten diamagnetic inequality implies the vanishing of the density of Lee-Yang zeros at θ=0 and has an important consequence: the absence of a first order phase transition at θ=0. The result provides a key missing link in the Vafa-Witten proof of parity symmetry conservation in vectorlike gauge theories and follows from renormalizability, unitarity, positivity, and existence of Bogomol'nyi-Prasad-Sommerfield bounds. Generalizations of this theorem to other physical systems are also discussed, with particular interest focused on the nonlinear CP N sigma model.

  1. Lee Miller, une battante sur tous les fronts

    Directory of Open Access Journals (Sweden)

    Anaïs Boutot

    2009-06-01

    Full Text Available L’art photographique de Lee Miller, à l’image de sa vie, revêt de multiples facettes. Après avoir été devant l’objectif en tant que mannequin puis égérie du Paris surréaliste, elle passe derrière l’objectif pour devenir photographe de mode, reporter de guerre ou encore portraitiste. L’exposition L’Art de Lee Miller, présentée au Jeu de Paume du 21 octobre 2008 au 4 janvier 2009 et accompagnée d’un ouvrage paru en français chez Hazan mettait en avant une quête d’identité et d’indépendance qui ...

  2. Economist Innovation Award for Tim Berners-Lee

    CERN Multimedia

    2003-01-01

    In September, Tim Berners-Lee, who invented the World Wide Web at CERN and is now Director of the W3C World Wide Web Consortium, received the 2nd Economist Annual Innovation Award in Computing. With the award The Economist, a British weekly newspaper, recognises individuals responsible for breakthroughs in Bioscience, Computing, Energy and the Environment, and Telecommunications that have a profound impact on industry. A fifth award is given in a special "No Boundaries" category, observing innovation that transcends industries. Candidates for the awards are proposed by The Economist readers and writers, and by a group of judges. Tim Berners-Lee received the Computing award for his global hypertext project, to be known as the World Wide Web, which "forever altered the way information is shared" and is a huge contribution to the efficiency of the scientific community. Based on a programme for storing information using random associations called "Enquire", it...

  3. What Lee Raymond actually said in Beijing [15th WPC

    International Nuclear Information System (INIS)

    Raymond, Lee.

    1997-01-01

    When Lee Raymond, Chairman and Chief Executive Officer, Exxon Corporation gave this keynote address at the recent World Petroleum Congress in Beijing, he drew attention to the way economic growth alleviates poverty and to the close linkage between economic growth and energy use. He also drew attention to the weakness of the scientific evidence for climate change being caused by fossil fuel burning and his doubts about the wisdom of setting targets for the reduction of CO 2 emissions. At a press conference after the presentation Lee Raymond assented to the suggestion that the European oil companies have been hijacked by the environmentalists. Petroleum Review has reproduced the full text of the speech so that readers can judge for themselves the merits of the arguments and their likely impact on the Kyoto conference. (UK)

  4. Fate of grape flavor precursors during storage on yeast lees.

    Science.gov (United States)

    Loscos, Natalia; Hernández-Orte, Purificación; Cacho, Juan; Ferreira, Vicente

    2009-06-24

    The effect of the addition of a grape flavor precursor extract to a grape juice, before or after fermentation with three different Saccharomyces cerevisiae yeast strains, on the evolution of the wine aroma composition during a 9-month aging period on yeast lees has been studied. Wine aroma compounds were determined by gas chromatography-mass spectrometry after alcoholic fermentation and after 3 and 9 months of storage. The aging of wine on lees caused important changes in the aroma profiles of wines, making the concentrations of three terpenes, norisoprenoids (except beta-damascenone and beta-ionone), 4-allyl-2,6-dimethoxyphenol, ethyl vanillate, syringaldehyde, and ethyl cinnamate increase, whereas the concentrations of most of the rest of compounds tended to decrease. Lees are responsible for the observed increasing trends, except for linalool and alpha-terpineol, and also for a large part of the observed decrements. As expected, the addition of precursors brings about an increment in the levels of most terpenes, norisoprenoids, vanillins, and ethyl cinnamate, and it is after an aging time when differences linked to the level of precursors in the must become more evident. The timing of the addition of precursors has a minor influence, except for beta-damascenone, vanillin, and syringaldehyde, for which supplementation after fermentation is more effective. It has also been observed that the precursor fraction makes the levels of vinylphenols decrease. Finally, it has also been found that lees from different yeast strains may have a slightly different abilities to release volatile compounds derived from precursors.

  5. Gettysburg: A Study of Lee’s Command Effectiveness, 1863

    Science.gov (United States)

    2011-03-21

    scholar of military history it is not necessary to focus strictly on the tactics of a single battle, or campaign, or even an entire war. To fully...the second day was the Peach Orchard and ultimately Cemetery Hill.48 The Peach Orchard was carried at a heavy cost but attacks on Little Round Top...Union troops to occupy the desired ground of the Peach Orchard and obtain positions on Little Round Top. Knowing Longstreet’s nature, Lee did not

  6. Tim Berners-Lee, World Wide Web inventor

    CERN Document Server

    1994-01-01

    Former physicist, Tim Berners-Lee invented the World Wide Web as an essential tool for high energy physics at CERN from 1989 to 1994. Together with a small team he conceived HTML, http, URLs, and put up the first server and the first 'what you see is what you get' browser and html editor. Tim is now Director of the Web Consortium W3C, the International Web standards body based at INRIA, MIT and Keio University.

  7. Triniti daripada Perspektif Taoisme: Analisis Pemikiran Jung Young Lee

    Directory of Open Access Journals (Sweden)

    ZURAIZA HUSIN

    2016-06-01

    Full Text Available Jung Young Lee is a Korean-born theologian who employs creatively the doctrine of the Trinity from an Asian worldview. This article aims to analyze Lee’s approaches of the Trinity with the Yin-Yang symbolism. The main reference is based on the book written by him entitled ‘The Trinity in Asian Perspective (1996’. Lee has turned his attention to the topic of Trinity through the lens of the culture and thought patterns of his own milieu. One of the leading point in presenting Yin-Yang principle as Trinitarian thinking, Lee examines the interpretation of the term “in” in the Bible, "Believe me that I am in the Father and the Father is in me" (John 14:11. The statement leads to the point that Yin and Yang cannot exist without each other because relationality is given priority than individuality. The idea is based on the terminology of ‘both/and’. So, ‘and’ indicates a Trinitarian statement, there is interdependence and unification. With reference to Trinity, the Father and the Son are One because of ‘and’. In addition, the same concept implements to the Holy Spirit. Lee views ‘and’ is not only a linking principle in both-and thinking but also the principle that is ‘between’ two. When ‘two’ exists, the third also exist between them. Based on the idea of ‘middle’, represents the connecting element between two, which contributes for the existence of the Third. Accordingly, the Spirit is the third element in the Trinity relationship.

  8. Did the "Woman in the Attic" in Jane Eyre Have Huntington Disease?

    Directory of Open Access Journals (Sweden)

    Elizabeth A. Coon

    2015-07-01

    Full Text Available Background: References to neurologic disorders are frequently found in fictional literature and may precede description in the medical literature. Aim: Our aim was to compare Charlotte Brontë’s depiction of Bertha Mason in Jane Eyre to the tenets set forth in George Huntington’s original essay “On chorea” with the hypothesis that Mason was displaying features of Huntington disease. Results: Charlotte Brontë’s 1847 Victorian novel Jane Eyre features the character Bertha Mason, who is portrayed with a progressive psychiatric illness, violent movements, and possible cognitive decline. Similar to Huntington’s tenets, Mason has a disorder with a strong family history suggestive of autosomal dominant inheritance with onset in adulthood, and culminating in suicide. Conclusion: Brontë’s character had features of Huntington disease as originally described by Huntington. Brontë’s keen characterization may have increased awareness of treatment of neuropsychiatric patients in the Victorian era.

  9. A Bold New Timeless Classic: Fukunaga’s Partial Reading of Jane Eyre

    Directory of Open Access Journals (Sweden)

    John Engle

    2012-07-01

    Full Text Available With its first person narrator, radical tonal changes, and wild blend of genres (autobiography, romance, Gothic melodrama, Christian exemplum, etc., Brontë’s Jane Eyre is a case study in the difficulties of cinematic adaptation, as the filmmaker attempts to balance "fidelity" with contemporary relevance and entertainment value. This article examines Cary Fukunaga’s 2011 version, and in particular certain orientations animating his necessarily "partial" reading of the novel. Chief among these is the decision to begin the film when Jane leaves Thornfield; recounting much of the story in discontinuous flashback, the film manages simultaneously to admit Jane’s narrative voice while eliminating its potentially distracting nature. Fukunaga’s other choices include the toning down of the novel’s lurid Gothic quality, its overt romanticism, and—today an overly familiar romantic comedy stereotype—the teasing interplay between the two protagonists. Communicating in a compact language of visual symbol, he also uses the original’s "religious plot" as a tool for modern character analysis.

  10. JANE, A new information retrieval system for the Radiation Shielding Information Center

    Energy Technology Data Exchange (ETDEWEB)

    Trubey, D.K.

    1991-05-01

    A new information storage and retrieval system has been developed for the Radiation Shielding Information Center (RSIC) at Oak Ridge National Laboratory to replace mainframe systems that have become obsolete. The database contains citations and abstracts of literature which were selected by RSIC analysts and indexed with terms from a controlled vocabulary. The database, begun in 1963, has been maintained continuously since that time. The new system, called JANE, incorporates automatic indexing techniques and on-line retrieval using the RSIC Data General Eclipse MV/4000 minicomputer, Automatic indexing and retrieval techniques based on fuzzy-set theory allow the presentation of results in order of Retrieval Status Value. The fuzzy-set membership function depends on term frequency in the titles and abstracts and on Term Discrimination Values which indicate the resolving power of the individual terms. These values are determined by the Cover Coefficient method. The use of a commercial database base to store and retrieve the indexing information permits rapid retrieval of the stored documents. Comparisons of the new and presently-used systems for actual searches of the literature indicate that it is practical to replace the mainframe systems with a minicomputer system similar to the present version of JANE. 18 refs., 10 figs.

  11. JANE, A new information retrieval system for the Radiation Shielding Information Center

    International Nuclear Information System (INIS)

    Trubey, D.K.

    1991-05-01

    A new information storage and retrieval system has been developed for the Radiation Shielding Information Center (RSIC) at Oak Ridge National Laboratory to replace mainframe systems that have become obsolete. The database contains citations and abstracts of literature which were selected by RSIC analysts and indexed with terms from a controlled vocabulary. The database, begun in 1963, has been maintained continuously since that time. The new system, called JANE, incorporates automatic indexing techniques and on-line retrieval using the RSIC Data General Eclipse MV/4000 minicomputer, Automatic indexing and retrieval techniques based on fuzzy-set theory allow the presentation of results in order of Retrieval Status Value. The fuzzy-set membership function depends on term frequency in the titles and abstracts and on Term Discrimination Values which indicate the resolving power of the individual terms. These values are determined by the Cover Coefficient method. The use of a commercial database base to store and retrieve the indexing information permits rapid retrieval of the stored documents. Comparisons of the new and presently-used systems for actual searches of the literature indicate that it is practical to replace the mainframe systems with a minicomputer system similar to the present version of JANE. 18 refs., 10 figs

  12. Re Jane.

    Science.gov (United States)

    1988-12-22

    The Family Court of Australia granted a parental petition requesting sterilization of their 17-year old mentally incompetent daughter. Earlier, after the parents had scheduled a hysterectomy, the Public Advocate had intervened, applying to the court for an injunction preventing the surgery. First, the court held that it was not required to examine or apply the provisions of the international Human Rights and Equal Opportunity Commission Act of 1986, since this agreement did not carry the force of law over the Australian Family Law Act of 1975. Second, the court concluded that it was the duty of the court, rather than of the parents, to determine the need for sterilization.

  13. Révision de Jane Eyre comme métacommentaire philosophique dans les romans d’Anita Brookner Re-Vision of Jane Eyre as Philosophical Metacomment in the Novels of Anita Brookner

    Directory of Open Access Journals (Sweden)

    Eileen Williams-Wanquet

    2009-10-01

    Full Text Available Although none of Brookner’s twenty-three novels to date actually re-write Jane Eyre as hypotext, Brontë’s novel is part of the pervasive intertextuality of Brookner’s text, addressed here as a monolithic fiction. This omnipresent intertextuality, which is the key to understanding the whole œuvre, serves to define the moral codes followed by the heroine and to make a philosophical metacommentary on contemporary culture. Brookner’s characters read and comment on Jane Eyre, the heroine takes Jane as a role model of virtue and the masculine characters are divided into those who resemble Mr Rochester and those who belong to the same category as St John Rivers. But Brookner’s text is a re-vision of Brontë’s novel, as of other novels set in the tradition of the classic realist text and of romance, which have Cartesian rationalism and Christianity as philosophical underpinnings. Brookner reverses the poetic justice of Jane Eyre, which is re-contextualised to fit a new moral landscape in which God is dead as ultimate justification for virtuous conduct. Whereas Jane Eyre can ultimately be read as a “Victorian romance” which preaches reason in the name of social order, by replacing the traditional happy ending by an unhappy ending in which virtue is punished and by foregrounding the disastrous effects of suppressing passion in the name of reason or self in the name of the other, Brookner announces the end of a philosophical humanistic tradition in which the subject / object or self / other opposition gives rise to a host of binary oppositions, the notion of centre validating the dominance of one of the terms of the hierarchy.

  14. Creative (misreading? Paula Rego’s Jane Eyre Jane Eyre vue par Paula Rego : de l’art de la (mauvaise lecture créatrice

    Directory of Open Access Journals (Sweden)

    Laurent Bury

    2009-07-01

    Full Text Available En 2002, l’artiste britannique d’origine portugaise Paula Rego a créé une série de vingt-cinq lithographies inspirées par Jane Eyre. Ces œuvres ont connu une popularité immédiate, malgré leur interprétation peu orthodoxe du roman de Charlotte Brontë. Les gravures de Paula Rego ont ainsi pu être qualifiées d’ « anti-illustrations » ou de « méta-images », mais cet article les considère comme une forme graphique de « lecture créative », voire de « mauvaise lecture créative », puisque l’on pourrait soupçonner Paula Rego d’avoir délibérément « mal lu » le roman. Cependant, dans sa relation avec les textes antérieurs, Charlotte Brontë elle-même était adepte de la « mauvaise lecture », ou du moins aimait à induire le lecteur en erreur.

  15. Modernizing the Harvard Observatory Catalog of Variable Stars in the Magellanic Clouds

    Science.gov (United States)

    Murray, Zachary; Kruk, Julia; Christie-Dervaux, Lucien; Chen, Dong Yi; Graur, Or; Pagnotta, Ashley

    2015-01-01

    We have modernized the Harvard College Observatory's catalog of variable stars in the Magellanic Clouds, compiled by Henrietta Swan Leavitt in 1908 and expanded by Cecilia Payne-Gaposchkin in 1966 and 1971. This catalog was originally used by Leavitt in 1912 to formulate the period-luminosity relation for Cepheid variable stars, one of the most important rungs on the extragalactic distance ladder. Many of the stars were identified in current catalogs by only their Harvard Variable number, without coordinates or magnitudes. We have digitized the variable-star catalog and converted the coordinates of the 2,184 variable stars from the Harvard College Observatory's now-defunct planar-grid system to the spherical Equatorial coordinate system. Our modernized version of the catalog will allow for more efficient use of the Harvard archival plates currently being scanned by the Digital Access to a Sky Century @ Harvard (DASCH) project. The combination of DASCH and our catalog allows users to readily access more than a century's worth of data on the variable stars in the Magellanic Clouds, leading to such projects as studying the long-term evolution of variable stars.

  16. Folklore et écriture vernaculaire dans The Autobiography of Miss Jane Pittman

    Directory of Open Access Journals (Sweden)

    Laurence Cossu-Beaumont

    2006-05-01

    Full Text Available On commencera par relever la richesse vernaculaire de la voix de Miss Jane et la densité folklorique de l’écriture de Gaines qui décrit ainsi son projet : « a folk autobiography ». Une autobiographie « folklorique » ? Certes, le rythme, la grammaire de l’anglais oral noir américain jalonnent ce récit qui se place lui-même dans son prologue sous le signe stylistique des conversations informelles sur les marches d’un perron de Louisiane, ces « porch talk » dont Gaines répète s’être inspiré.Cependant, l’analyse confinerait à la couleur locale si la « folk autobiography » n’était pas lue comme autobiographie fictive d’un peuple et d’une stratégie de survie : Miss Jane incarne aussi la dimension fonctionnelle du parler vernaculaire dont la théorie de signifyin(g a montré les enjeux vitaux. La jeune Jane, tout juste libérée de son nom d’esclave, possède déjà les « armes » verbales pour attaquer une société vacillante. Elle parvient à « éliminer » un adversaire des plus symboliques, le contremaître noir, en le réduisant à néant dans une réplique emblématique du pouvoir du signifyin(g (« You ain’t nothing but Nothing » p. 11. La veille femme, sage mais non résignée, devient trickster à la fin du récit. Dans une évocation performative (on notera le jeu des « to stand », « to march » p. 257, elle fait plus que « raconter » son histoire et parvient à « créer » l’Histoire en guidant et modifiant le destin de toute une communauté.On suggérera encore que cette « folk autobiography », autobiographie d’un peuple ou d’une culture, ne se laisse pas réduire à la seule communauté noire. Le récit est ancré dans la culture de la Louisiane, une culture complexe où maîtres blancs et esclaves puis métayers noirs traversent des tragédies communes, et écrivent ensemble leur Histoire commune dans une langue vernaculaire qu’ils partagent aussi

  17. "Secrets of the female sex": Jane Sharp, the reproductive female body, and early modern midwifery manuals.

    Science.gov (United States)

    Hobby, E

    2001-01-01

    Early modern midwifery manuals in Britain were usually the work of men. These books were a significant source of information about the body to the wider reading public: many sold well, and their prefatory materials include injunctions to readers not to make improper use of them. What is particularly interesting about Jane Sharp's Midwives Book (1671) is that it both provides a compendium of current beliefs concerning reproduction, and indicates the author's ironic perception of the misogyny that underpinned accepted ideas about the female reproductive body. This article gives key examples of Sharp's interventions, and also refers to Thomas Bartholin, Bartholinus Anatomy (1688); Richard Bunworth, The Doctresse (1656); Hugh Chamberlen, The Accomplisht Midwife (1673); The Compleat Midwifes Practice (1656); Helkiah Crooke, Microcosmographia (1615); Nicholas Culpeper, A Directory for Midwives (1651); Jacques Guillemeau, Childbirth (1612); Jean Riolan, A Sure Guide (1657); Daniel Sennert, Practical Physick (1664); William Sermon, The Ladies Companion (1671); and Percival Willughby, Observations in Midwifery (c. 1675).

  18. Norms for the Korean version of the Harvard Group Scale of Hypnotic Susceptibility, Form A.

    Science.gov (United States)

    Pyun, Young Don; Kim, Yun Joo

    2009-01-01

    The Korean Version of the Harvard Group Scale of Hypnotic Susceptibility, Form A (HGSHS:K) was adapted and studied in order to determine Korean norms. In total, 271 subjects (175 males and 96 females) participated in the study. Comparisons are made between the Korean samples and previously published international samples. The normative data from the Korean sample on the HGSHS:K are generally congruent, including means and standard deviations, with data from international reference samples. However, the pass rate on the hallucination item on the Harvard Group Scale of Hypnotic Susceptibility, Form A, was significantly different from that of the American sample. Females showed higher overall scores than males.

  19. Phenolic characterization of aging wine lees: Correlation with antioxidant activities.

    Science.gov (United States)

    Romero-Díez, R; Rodríguez-Rojo, S; Cocero, M J; Duarte, C M M; Matias, A A; Bronze, M R

    2018-09-01

    Aging wine lees are water-wastes produced during the wine aging inside wood barrels that can be considered as alternative sources of bioactive compounds. Phenolic characterization and antioxidant activity (AA) measurements of wines lees solid-liquid extracts have been undertaken on a dry extract (DE) basis. Solvents with different polarities (water, methanol, ethanol, two hydroalcoholic mixtures and acetone) were used. Total phenolic (TPC) and total flavonoid contents (TFC) were determined. The mixture of 75:25(v/v) EtOH:H 2 O showed the highest values with 254 mg GAE /g DE and 146 mg CATE /g DE respectively. HORAC, HOSC and FRAP were used to determine the AA of the extracts being also highest for the mixture of 75:25(v/v) EtOH:H 2 O (4690 µmol CAE /g DE , 4527 µmol TE /g DE and 2197 µmol TE /g DE , respectively). For ORAC method, methanol extract showed the best value with 2771 µmol TE /g DE . Correlations between TPC, TFC, phenolic compounds and AA were determined. Most relevant compounds contributing to AA were identified using data from mass spectrometry, being mainly anthocyanins. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. Rita Braches-Chyrek, Jane Addams, Mary Richmond und Alice Salomon: Professionalisierung und Disziplinbildung Sozialer Arbeit. Opladen: Barbara Budrich 2013 (340 S.) [Rezension

    OpenAIRE

    Lau, Dayana

    2013-01-01

    Rezension von: Rita Braches-Chyrek, Jane Addams, Mary Richmond und Alice Salomon: Professionalisierung und Disziplinbildung Sozialer Arbeit. Opladen: Barbara Budrich 2013 (340 S.; ISBN 978-3-8474-0015-8)

  1. Robert E. Lee as Operational Artist During the American Civil War

    Science.gov (United States)

    2010-04-21

    Johnston was just as arrogant as Davis. During his tenure as a student at the United States Military Academy Johnston eamed the nickname "Colonel" from his...shown previous subordinate leaders .. Lee had certainly eamed it based on his reputation and performance at Second Manassas and during his tenure as...Washington, PA: EasternNational. Roland, Charles P. 1964. The Generalship of Robert E. Lee. In Grant, Lee, Lincoln and The Radicals; Essays on

  2. Wrong vertex displacements due to Lee-Wick resonances at LHC

    International Nuclear Information System (INIS)

    Alvarez, E.; Schat, C.; Rold, L. da; Szynkman, A.

    2009-01-01

    We show how a resonance from the recently proposed Lee-Wick Standard Model could lead to wrong vertex displacements at LHCb. We study which could be the possible 'longest lived' Lee-Wick particle that could be created at LHC, and we study its possible decays and detections. We conclude that there is a region in the parameter space which would give wrong vertex displacements as a unique signature of the Lee-Wick Standard Model at LHCb. Further numerical simulation shows that LHC era could explore these wrong vertex displacements through Lee-Wick leptons below 500 GeV. (author)

  3. Implementation of the Harvard Case Method through a Plan-Do-Check-Act Framework in a University Course

    Science.gov (United States)

    Shieh, Ruey S.; Lyu, Jr Jung; Cheng, Yun-Yao

    2012-01-01

    In 2005, the Harvard Business School began to promote the Harvard case method (HCM) within the Asian region. Because of differences in classroom culture between Asian and Western countries, Asian participants' reaction to the HCM implementation is of interest. This study explores how the western initiated method was implemented in one of the Asian…

  4. Harvard University: Green Loan Fund. Green Revolving Funds in Action: Case Study Series

    Science.gov (United States)

    Foley, Robert

    2011-01-01

    The Green Loan Fund at Harvard University has been an active source of capital for energy efficiency and waste reduction projects for almost a decade. This case study examines the revolving fund's history from its inception as a pilot project in the 1990s to its regeneration in the early 2000s to its current operations today. The green revolving…

  5. The Flip Sides of Full-Text: Superindex and the Harvard Business Review/Online.

    Science.gov (United States)

    Dadlez, Eva M.

    1984-01-01

    This article illustrates similarities between two different types of full-text databases--Superindex, Harvard Business Review/Online--and uses them as arena to demonstrate search and display applications of full-text. The selection of logical operators, full-text search strategies, and keywords and Bibliographic Retrieval Service's Occurrence…

  6. Searching Harvard Business Review Online. . . Lessons in Searching a Full Text Database.

    Science.gov (United States)

    Tenopir, Carol

    1985-01-01

    This article examines the Harvard Business Review Online (HBRO) database (bibliographic description fields, abstracts, extracted information, full text, subject descriptors) and reports on 31 sample HBRO searches conducted in Bibliographic Retrieval Services to test differences between searching full text and searching bibliographic record. Sample…

  7. Harvard University Program on Technology and Society 1964-1972. A Final Review.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Program on Technology and Society.

    Eight years of research by the Harvard University's Program on Technology and Society are summarized. Lengthy abstracts of the 29 books and 164 articles that resulted from the Program, as well as interim accounts of projects not yet completed are presented. The report is divided into four parts; institutions (including business, education, and…

  8. Establishment of the Department of Anaesthesia at Harvard Medical School-1969.

    Science.gov (United States)

    Mizrahi, Ilan; Desai, Sukumar P

    2016-02-01

    The first academic departments of anesthesia were established in the United States at the University of Wisconsin-Madison in 1927, with Ralph M. Waters named as chairman, and in the UK at Oxford University in 1937, with Robert Macintosh as chairman. Compared to these early departments, more than 3 decades would pass before Harvard Medical School decided it was time to establish a department of anaesthesia, in 1969. We examine the forces on both sides of the issue, for and against, and how they played out in the late 1960s. Published articles, books, interviews, and biographical and autobiographical notes as well as primary source documents such as reports of department and medical school committee meetings were examined to obtain information relevant to our investigation. The late 1960s were an ideal time for the chiefs of anesthesia at the various Harvard teaching hospitals to make a strong argument in favor of establishment of an independent department of anaesthesia. Although strongly opposed by Francis Daniels Moore, Chief of Surgery at Peter Bent Brigham Hospital, an independent department at Harvard was established in 1969. The recognition of anesthesia as a distinctive specialty at universities across the country as well as the specific concerns over administration, hiring, and the future of the clinical service in the 1960s provided overwhelming support for the establishment of a separate, free-standing department of anaesthesia at one of the most tradition-bound universities in the United States-Harvard. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Chronic N-amended soils exhibit an altered bacterial community structure in Harvard Forest, MA, USA

    Science.gov (United States)

    Swathi A. Turlapati; Rakesh Minocha; Premsai S. Bhiravarasa; Louise S. Tisa; William K. Thomas; Subhash C. Minocha

    2013-01-01

    At the Harvard Forest, Petersham, MA, the impact of 20 years of annual ammonium nitrate application to the mixed hardwood stand on soil bacterial communities was studied using 16S rRNA genes pyrosequencing. Amplification of 16S rRNA genes was done using DNA extracted from 30 soil samples (three treatments x two horizons x five subplots) collected from untreated (...

  10. 75 FR 28648 - Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard University...

    Science.gov (United States)

    2010-05-21

    ... National Park Service Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard... completion of an inventory of human remains in the possession of the Peabody Museum of Archaeology and... remains was made by the Peabody Museum of Archaeology and Ethnology professional staff in consultation...

  11. Psychiatry in the Harvard Medical School-Cambridge Integrated Clerkship: An Innovative, Year-Long Program

    Science.gov (United States)

    Griswold, Todd; Bullock, Christopher; Gaufberg, Elizabeth; Albanese, Mark; Bonilla, Pedro; Dvorak, Ramona; Epelbaum, Claudia; Givon, Lior; Kueppenbender, Karsten; Joseph, Robert; Boyd, J. Wesley; Shtasel, Derri

    2012-01-01

    Objective: The authors present what is to their knowledge the first description of a model for longitudinal third-year medical student psychiatry education. Method: A longitudinal, integrated psychiatric curriculum was developed, implemented, and sustained within the Harvard Medical School-Cambridge Integrated Clerkship. Curriculum elements…

  12. THE INFLUENCE OF SOCIAL STATUS AND SOLIDARITY TO THE QUANTITY OF UTTERANCES IN JANE AUSTEN’S NOVELS

    Directory of Open Access Journals (Sweden)

    Citra Suryanovika

    2018-03-01

    Fokus penelitian pada ujaran yang disampaikan oleh tokoh utama perempuan dalam enam novel Jane Austen. Penelitian bertujuan menelaah pengaruh status sosial dan solidaritas pada kuantitas ujaran. Hasil penelitian menunjukkan 1,738 dengan rincian 266 ujaran Elinor Dashwood, 368 ujaran Elizabeth Bennet, 194 ujaran Fanny Price, 473 ujaran Emma Woodhouse, 113 ujaran Anne Elliot, and 324 ujaran Catherine Morland. Berdasarkan peringkat, status sosial tinggi Emma Woodhouse menghasilkan jumlah ujaran paling banyak, dibandingkan dengan lima tokoh lainnya, namun Fanny Price dengan status sosial paling bawah berada di peringkat kelima dari enam tokoh yang ditelaah. Telaah keakraban menunjukkan 66,7% jumlah ujaran dengan skala solidaritas tinggi, dan 33,3% ujaran dengan skala solidaritas rendah. Berdasarkan hasil analisa, dapat disimpulkan bahwa penentu kuantitas ujaran bukan hanya ditentukan oleh status sosial dan solidaritas karakter, tapi juga ditentukan oleh ketertarikan dan rasa penasaran. Kata kunci: Status Sosial, Skala Solidaritas, Ujaran, Jane Austen.

  13. The Friedberg-Lee symmetry and minimal seesaw model

    International Nuclear Information System (INIS)

    He Xiaogang; Liao Wei

    2009-01-01

    The Friedberg-Lee (FL) symmetry is generated by a transformation of a fermionic field q to q+ξz. This symmetry puts very restrictive constraints on allowed terms in a Lagrangian. Applying this symmetry to N fermionic fields, we find that the number of independent fields is reduced to N-1 if the fields have gauge interaction or the transformation is a local one. Using this property, we find that a seesaw model originally with three generations of left- and right-handed neutrinos, with the left-handed neutrinos unaffected but the right-handed neutrinos transformed under the local FL translation, is reduced to an effective theory of minimal seesaw which has only two right-handed neutrinos. The symmetry predicts that one of the light neutrino masses must be zero.

  14. Searching for Lee-Wick Gauge Bosons at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Rizzo, Thomas G.

    2007-04-30

    In an extension of the Standard Model(SM) based on the ideas of Lee and Wick, Grinstein, O'Connell and Wise have found an interesting way to remove the usual quadratically divergent contributions to the Higgs mass induced by radiative corrections. Phenomenologically, the model predicts the existence of Terascale, negative-norm copies of the usual SM fields with rather unique properties: ghost-like propagators and negative decay widths, but with otherwise SM-like couplings. The model is both unitary and causal on macroscopic scales. In this paper we examine whether or not such states with these unusual properties can be uniquely identified as such at the LHC. We find that in the extended strong and electroweak gauge boson sector of the model, which is the simplest one to analyze, such an identification can be rather difficult. Observation of heavy gluon-like resonances in the dijet channel offers the best hope for this identification.

  15. THE YUAN-TSEH LEE ARRAY FOR MICROWAVE BACKGROUND ANISOTROPY

    International Nuclear Information System (INIS)

    Ho, Paul T. P.; Altamirano, Pablo; Chang, C.-H.; Chang, S.-H.; Chang, S.-W.; Chen, C.-C.; Chen, K.-J.; Chen, M.-T.; Han, C.-C.; Ho, West M.; Huang, Y.-D.; Hwang, Y.-J.; Ibanez-Romano, Fabiola; Jiang Homin; Koch, Patrick M.; Kubo, Derek Y.; Li, C.-T.; Lim, Jeremy; Lin, K.-Y.; Liu, G.-C.

    2009-01-01

    The Yuan-Tseh Lee Array for microwave background anisotropy is the first interferometer dedicated to study the cosmic microwave background radiation at 3 mm wavelength. The choice of 3 mm is to minimize the contributions from foreground synchrotron radiation and Galactic dust emission. The initial configuration of seven 0.6 m telescopes mounted on a 6 m hexapod platform was dedicated in 2006 October on Mauna Loa, Hawaii. Scientific operations began with the detection of a number of clusters of galaxies via the thermal Sunyaev-Zel'dovich effect. We compare our data with Subaru weak-lensing data to study the structure of dark matter. We also compare our data with X-ray data to derive the Hubble constant.

  16. Perturbative unitarity of Lee-Wick quantum field theory

    Science.gov (United States)

    Anselmi, Damiano; Piva, Marco

    2017-08-01

    We study the perturbative unitarity of the Lee-Wick models, formulated as nonanalytically Wick rotated Euclidean theories. The complex energy plane is divided into disconnected regions and the values of a loop integral in the various regions are related to one another by a nonanalytic procedure. We show that the one-loop diagrams satisfy the expected, unitary cutting equations in each region: only the physical d.o.f. propagate through the cuts. The goal can be achieved by working in suitable subsets of each region and proving that the cutting equations can be analytically continued as a whole. We make explicit calculations in the cases of the bubble and triangle diagrams and address the generality of our approach. We also show that the same higher-derivative models violate unitarity if they are formulated directly in Minkowski spacetime.

  17. ‘Dolls in Agony’: Vernon Lee in Southern Spain

    OpenAIRE

    Barrera-Medrano, Leire

    2016-01-01

    Lorsque Vernon Lee se rendit dans le sud de l’Espagne en 1889, elle trouva que les pratiques catholiques qui y étaient exercées étaient extrêmement déroutantes. La décoration excessive des églises et le penchant local pour des représentations sanglantes du Christ en croix étaient, d’après elle, « obscènes » et « excessives ». En particulier, la représentation des Madones espagnoles, constamment figurées éplorées, lui répugnait. Ce sentiment de rejet envers ce pays catholique et plus particuli...

  18. La felicidad como represión: orden y desorden en Jane Eyre y El vasto mar de los Sargazos

    Directory of Open Access Journals (Sweden)

    Mónica Roesel

    2014-01-01

    Full Text Available Este ensayo traza las historias de Jane Eyre, protagonista de la novela homónima (Charlotte Brontë 1847, y Antoinette Cosway, protagonista de El vasto mar de los Sargazos (Jean Rhys 1966. Son historias paralelas de abandono y búsquedas fallidas que convergen en un punto: Edward Rochester. Se sugiere que el final feliz de Jane y el final trágico de Antoinette están determinados por la imposibilidad del etos victoriano, encarnado en Rochester, de aceptar el caos: el desorden que representa Antoinette —desorden de la alteridad— debe ser sometido. La represión, entonces, aparece como única posibilidad de existencia. This essay traces the stories of Jane Eyre, the heroine of the homonymous novel (Charlotte Brontë, 1847, and Antoinette Cosway, the heroine of Wide Sargasso Sea (Jean Rhys, 1966. These parallel stories of abandonment and failed searches converge in one point: Edward Rochester. It is suggested that Jane’s happy ending and Antoinette’s tragic ending are both determined by the impossibility of the Victorian ethos, personified in Rochester, to accept chaos: the disorder represented by Antoinette —disorder of alterity— must be tamed. Repression, then, appears as the sole possibility of existence.

  19. ERNEST J. GAINES’S MISS JANE PITTMAN: A SYMBOL OF THE BLACK FEMALE ABOLITIONIST STRUGGLE / « MADEMOISELLE JANE PITTMAN » D'ERNEST J. GAINES: UN SYMBOLE DE LA LUTTE ABOLITIONNISTE MENÉE PAR LES FEMMES DE COULEUR / "DOMNIŞOARA JANE PITTMAN” DE ERNEST J. GAINES: SIMBOL AL LUPTEI ABOLIŢIONISTE DUSE DE FEMEILE DE CULOARE

    Directory of Open Access Journals (Sweden)

    Ettien Yapo

    2014-11-01

    Full Text Available The Autobiography of Miss Jane Pittman by Ernest J. Gaines is a testimony of the black female abolitionist struggle. Its protagonist, Miss Jane Pittman, whose life covers the Civil War period (1861-1865 and the 1960s, embodies the African American women’s experience through her own story. As Ernest J. Gaines gives her the voice to relate her life experience, she reflects on her being and at the same time, she constructs her identity which reveals her heroism. Her struggle for freedom turns around her participation in the Civil War and the Civil Rights Movement. But her attempt to reach the North after the Civil War remains an important fact of her struggle. As a symbol of the black female abolitionist struggle, her “autobiography” is the voiceless African American women’s point of view.

  20. A multi-developing-country comparison of the lee-carter model for ...

    African Journals Online (AJOL)

    This study evaluate the Lee-Carter model for projecting age and gender specific mortality rates and life expectancy at births in four developing countries namely Malaysia, Indonesia, Thailand and Singapore. Although the Lee-Carter model has been successfully applied in many developed countries, little information is ...

  1. Tim Berners-Lee at the RSIS conference from 8-9 December 2003.

    CERN Multimedia

    Patrice Loiez

    2003-01-01

    Tim Berners-Lee participated in the Role of Science in the Information Society conference held at CERN from 8-9 December 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  2. Grain-size sorting in grainflows at the lee side of deltas

    NARCIS (Netherlands)

    Kleinhans, M.G.

    2005-01-01

    The sorting of sediment mixtures at the lee slope of deltas (at the angle of repose) is studied with experiments in a narrow, deep flume with subaqueous Gilbert-type deltas using varied flow conditions and different sediment mixtures. Sediment deposition and sorting on the lee slope of the delta

  3. Odd complaints and doubtful conditions: norms of hypochondria in Jane Austen and Catherine Belling.

    Science.gov (United States)

    Nelson, James Lindemann

    2014-06-01

    In her final fragmentary novel Sanditon, Jane Austen develops a theme that pervades her work from her juvenilia onward: illness, and in particular, illness imagined, invented, or self-inflicted. While the "invention of odd complaints" is characteristically a token of folly or weakness throughout her writing, in this last work imagined illness is also both a symbol and a cause of how selves and societies degenerate. In the shifting world of Sanditon, hypochondria is the lubricant for a society bent on turning health into a commodity. As a result, people's rationality and their moral character come under attack. Catherine Belling's recent subtle study, A Condition of Doubt: The Meanings of Hypochondria, unveils hypochondria's discursive and cultural character. Running sharply against the tenor of Austen's treatment, however, she argues in defense of the rationality of hypochondriacs; the notion that the condition may involve morally significant defects is not entertained; any connection to the commercialization of health care is muted. Here, I contrast Austen's morally and epistemically negative rendering of her hypochondriacal characters in Sanditon with Belling's efforts to create a sympathetic understanding of people with hypochondria. I will argue that, despite time gaps and genre differences, joint consideration of these texts can help bioethicists better appreciate how medicine can intensify, pathologize, and exploit anxieties about illness and death, thus adding to the challenges of living well in the face of mortality and morbidity.

  4. "A hint of it, with initials": adultery, textuality and publicity in Jane Austen's Lady Susan.

    Science.gov (United States)

    Russell, Gillian

    2010-01-01

    In spite of Jane Austen's professed “eye” for an adulteress, comparatively little attention has been paid to adultery and divorce as themes and contexts of her fiction. Her unpublished epistolary novel Lady Susan has a distinctive status in Austen's oeuvre, recognized as being exemplary of her “style” and yet atypical of her later achievement. A neglected context for the novel is the extensive reporting of adultery trials in contemporary print culture and the moral panic concerning adultery in the 1780s and 1790s, focusing initially on the adulteress as the brazen woman of fashion and later as a figure of sentimentalized abjection. A particularly notorious case, that involving Lady Henrietta Grosvenor and George III's brother, the Duke of Cumberland, is directly alluded to in Lady Susan. The textual strategies of adultery trial literature, particularly its emphasis on indirection through the use of detail or “hint”, had a long-term influence on the development of Austen's fiction and her positioning of herself as a professional writer after the 1790s.

  5. Adaptation-induced Tourism for Consumers of Literature on Screen: the Experience of Jane Austen Fans

    Directory of Open Access Journals (Sweden)

    Maddalena Pennacchia

    2015-03-01

    Full Text Available My aim in this article is that of starting to relate the expanding research field of adaptation studies to the subject area of film-induced tourism. Adaptations are a specific typology of films: that is, films whose story was not originally intended for the screen but, more often than not, for the written page, and has, therefore, been ‘translated’ into a new medium. The phenomenon of adaptation has been at the center of a heated debate for a few years now, but the specific link between adaptation and tourism has not yet been studied in its own right. In my article I question why and how adaptations of literary texts for the screen can induce a desire to visit film locations (actual geographical places in readers who are also inclined to enjoy the experience of “literature on screen”. In order to do this, I focus on the case study of adaptations from Jane Austen’s novels and on a specific kind of tourists, the so called ‘Janeites’, or Austen fans.

  6. JANE JACOBS. “MUERTE Y VIDA DE LAS GRANDES CIUDADES”

    Directory of Open Access Journals (Sweden)

    José Altés Bustelo

    2011-05-01

    Full Text Available La primera edición de este libro apareció en 1961 en Nueva York. (Random House Inc. Edit.. Y la primera traducción en castellano, de Angel Abad, apareció en España sorprendentemente pronto, en enero de 1967, editada por Península. (Ediciones 62, Barcelona.El texto de Jane Jacobs se inicia con su ya famosa frase: "Este libro es un ataque contra las teorías más usuales sobre urbanización y reconstrucción de ciudades,..." advertencia insólita, aunque innecesaria si uno continua leyendo.Fruto de la experiencia directa, atenta, sensible, perspicaz, abierta a la observación y marcada por el amor y compromiso con su ciudad, Nueva York, y sus convecinos, y contrastada con minuciosos análisis en múltiples otras ciudades, J.J. nos desgrana una extensa cadena de reflexiones sobre la experiencia vivida de la realidad cotidiana en las distintas escalas de la ciudad: calle, barriada, distrito, sus límites y fronteras, parques y vacíos, comunicaciones, etc., y la constatación detallada del fracaso, siempre, en la acción de políticos, planificadores y arquitectos

  7. Janeites for a New Millennium: The Modernisation of Jane Austen on Film

    Directory of Open Access Journals (Sweden)

    Elzette Steenkamp

    2009-05-01

    Full Text Available The late twentieth century saw a surge in cinematic adaptations of Jane Austen’s novels, the films generating wide-spread interest and zeal from a new caste of modern-day Janeites, many of whom were previously unfamiliar with Austen’s work. While the notion of a Janeite culture based purely on motion picture renditions of the original novels is sure to displease literary purists, the purpose of this discussion is not to initiate a debate regarding our responsibility to remain faithful to Austen in her original form. Rather, this article identifies the type of cinematic alterations and emphases which render Austen films more appealing to a certain group of modern-day Janeites. It will be argued that modern-day audiences’ demand for recognisably modern protagonists necessitates the modernization of Austen on film. Thus, cinematic adaptations tend to emphasize Austen’s nascent feminism, re-imagining her heroines as more fiercely independent, lively and witty than their original incarnations. Through additional scenes, altered dialogue and substantial changes to the characters, film producers not only highlight the plight of women in the early nineteenth century, but also circumvent such restrictions by allowing their female protagonists the degree of independence demanded by modern-day audiences.

  8. Pragmatist Epistemology and Jane Addams: Fundamental Concepts for the Social Paradigm of Occupational Therapy.

    Science.gov (United States)

    Morrison, Rodolfo

    2016-12-01

    The objective of this manuscript is to contribute to the education of future occupational therapists within the current paradigm of the profession. To this purpose, some of the conceptual foundations of pragmatist epistemology and philosophical contributions of the philosopher Jane Addams are presented. Some pragmatist fundamentals such as the holistic vision of the human being, the paradox of separating "knowing from doing", and giving the usefulness of the activity and knowledge primacy in the process of human development, inspired the profession of Occupational Therapy in the United States at the beginning of the twentieth century. Today, almost 100 years after the founding of the National Society for the Promotion of Occupational Therapy, pragmatism is still relevant to the profession. Specifically, its pertinence is related to the current scenario of the profession, and its powerful development in working scopes related to socio-community fields. This helps identify how we are on the verge of another paradigm, known as Social Paradigm of the Occupation. This new social understanding of the discipline allows us to understand the relevance of professional work in community or social contexts. Future research could address how the pragmatism contributes to the understanding of occupation as a social phenomenon within this new paradigm. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  9. Characteristics and stabilities of residues from the Wheal Jane constructed wetlands.

    Science.gov (United States)

    Swash, P M; Monhemius, A J

    2005-02-01

    The characteristics and solubilities of residues formed during effluent treatment at the Wheal Jane constructed wetland facility in Cornwall, UK are described. The constructed wetland treats an acidic (pH 3 to 4) mine discharge enriched in iron (circuits. Solubility tests conducted on the materials from the aerobic and anaerobic cells attempt to simulate future possible leaching processes within landfill sites used for ultimate disposal. The tests used in the evaluation included TCLP, MARG, washing and column leaching. The aerobic solids overall have very low solubilities which are well below the TCLP thresholds for As, Cd and Pb. The TCLP results for these toxic elements are supported by the washing and column test work. The anaerobic substrates are carbonaceous in nature, composed of straw, wood pulp and manure. They contain minimal amounts of toxic compounds and are considered to be less of a disposal problem. Ochre precipitated at a pH of 3-4 in the aerobic cells contains significant concentrations of arsenic (>0.1%). This element is carcinogenic, and such residues are classified as hazardous waste under current UK landfill regulations. This classification does not take into consideration the solubility of the material but is based solely on the bulk chemical composition.

  10. BIS impulsivity and acute nicotine exposure are associated with discounting global consequences in the Harvard game.

    Science.gov (United States)

    Hogarth, Lee; Stillwell, David J; Tunney, Richard J

    2013-01-01

    The Barratt Impulsivity Scale (BIS) provides a transdiagnostic marker for a number of psychiatric conditions and drug abuse, but the precise psychological trait(s) tapped by this questionnaire remain obscure. To address this, 51 smokers completed in counterbalanced order the BIS, a delay discounting task and a Harvard game that measured choice between a response that yielded a high immediate monetary payoff but decreased opportunity to earn money overall (local choice) versus a response that yielded a lower immediate payoff but afforded a greater opportunity to earn overall (global choice). Individual level of BIS impulsivity and self-elected smoking prior to the study were independently associated with increased preference for the local over the global choice in the Harvard game, but not delay discounting. BIS impulsivity and acute nicotine exposure reflect a bias in the governance of choice by immediate reward contingencies over global consequences, consistent with contemporary dual-process instrumental learning theories. Copyright © 2013 John Wiley & Sons, Ltd.

  11. "They Sweat for Science": The Harvard Fatigue Laboratory and Self-Experimentation in American Exercise Physiology.

    Science.gov (United States)

    Johnson, Andi

    2015-08-01

    In many scientific fields, the practice of self-experimentation waned over the course of the twentieth century. For exercise physiologists working today, however, the practice of self-experimentation is alive and well. This paper considers the role of the Harvard Fatigue Laboratory and its scientific director, D. Bruce Dill, in legitimizing the practice of self-experimentation in exercise physiology. Descriptions of self-experimentation are drawn from papers published by members of the Harvard Fatigue Lab. Attention is paid to the ethical and practical justifications for self-experimentation in both the lab and the field. Born out of the practical, immediate demands of fatigue protocols, self-experimentation performed the long-term, epistemological function of uniting physiological data across time and space, enabling researchers to contribute to a general human biology program.

  12. James Lee Byars 1/2 an autobiography, sourcebook

    CERN Document Server

    Byars, James Lee; Eleey, Peter

    2014-01-01

    "I see my autobiography as an arbitrary segment of so many pages of time, of things that I have paid attention to at this point in my life," wrote James Lee Byars (1932-1997) in 1969. He was then 37, about half the average male lifespan at the time, and accordingly thought it appropriate to write his "1/2 autobiography." Byars' art ranged from highly refined objects to extremely minimal performance and events, and books, ephemera and correspondence that he distributed widely among friends and colleagues. Today, more than 15 years after his death, assessments of his art must negotiate Byars' performance of his charismatic self in his life and art. For his first major posthumous survey in the US, exhibition curators Magalí Arriola and Peter Eleey decided to produce a catalogue in two "halves," playing on his "1/2 autobiography": a catalogue of the exhibition itself, including new scholarship, and a sourcebook of primary documents. 1/2 an Autobiography, Sourcebook constitutes the latter volume--a reference guid...

  13. The Sociology of the Deceased Harvard Medical Unit at Boston City Hospital

    OpenAIRE

    Tishler, Peter V.

    2015-01-01

    Many graduates of the Harvard Medical Unit (HMU) at Boston City Hospital, in either the clinical training/residency program or the research program at the Thorndike Memorial Laboratory, contributed in major ways to the HMU and constantly relived their HMU experiences. The HMU staff physicians, descending from founder and mentor physicians Francis W. Peabody, Soma Weiss, and George R. Minot, were dedicated to the teaching, development, and leadership of its clinical and research trainees, whos...

  14. The watershed years of 1958-1962 in the Harvard Pigeon Lab.

    OpenAIRE

    Catania, A Charles

    2002-01-01

    During the years 1958-1962, the final years of support by the National Science Foundation for B. F. Skinner's Pigeon Lab in Memorial Hall at Harvard University, 20 or so pigeon experiments (plus some with other organisms) ran concurrently 7 days a week. The research style emphasized experimental analyses, exploratory procedures, and the parametric exploration of variables. This reminiscence describes some features of the laboratory, the context within which it operated, and the activities of ...

  15. Connecting the Plots: The Extension of Return and Korean Ethnic Nationalism in Jane Jeong Trenka’s 'Fugitive Visions'

    OpenAIRE

    Waddell, Ethan

    2017-01-01

    Thousands of overseas Korean adoptees return to Korea temporarily each year in search of their true origin, but few choose to stay permanently. A prominent member of this small community is Jane Jeong Trenka, author of two memoirs: The Language of Blood (2003) and Fugitive Visions: An Adoptee’s Return to Korea (2009). This article analyses Trenka’s literary struggle for permanence in Fugitive Visions through theories on Korean ethnic national identity. Using Marshall McLuhan’s idea of media a...

  16. La influencia de la Postmodernidad en Orgullo y Prejuicio (1813): Persiguiendo a Jane Austen (2008), Dan Zeff.

    OpenAIRE

    Irene Romero González

    2012-01-01

    Las novelas de Jane Austen siguen inspirando nuevos relatos cinematográficos pues éstos toman sus historias o sus personajes y los adaptan a contextos culturales y axiológicos actuales de gran diversidad. Es el caso de la novela de Orgullo y Prejuicio de la que se han realizado numerosas adaptaciones clásicas, así como que ha sido objeto de referencia en películas, en trabajos literarios y de adaptaciones postmodernas. Uno de estos trabajos postmodern...

  17. Test procedure for the Master-Lee and the modified Champion four inch hydraulic cutters

    International Nuclear Information System (INIS)

    Crystal, J.B.

    1995-01-01

    The Master-Lee and the modified Champion 4 Inch hydraulic cutters are being retested to gather and document information related to the following: determine if the Master-Lee cutters will cut the trunnions of an Aluminum fuel canister and a Stainless Steel fuel canister; determine if the Master-Lee cutters will cut 1 1/2 inch diameter fire hose; determine if the modified Champion 4 inch blade will cut sections of piping; and determine the effectiveness of the centering device for the Champion 4 Inch cutters. Determining the limitations of the hydraulic cutter will aid in the process of debris removal in the K-Basin. Based on a previous test, the cutters were returned to the manufacturer for modifications. The modifications to the Champion 4 Inch Cutter and further testing of the Master-Lee Cutter are the subjects of these feature tests

  18. 75 FR 11225 - Environmental Impact Statement; Lee and Collier Counties, Florida

    Science.gov (United States)

    2010-03-10

    ... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement; Lee and Collier Counties, Florida AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of... INFORMATION CONTACT: Mr. George Hadley, Environmental Programs Coordinator, Federal Highway Administration...

  19. Näitleja Tommy Lee Jonesi meditatsioon režissööritoolis / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2007-01-01

    Vestern "Melquiades Estrada kolm matust" ("The Three Burials of Melquiades Estrada") : stsenarist Guillermo Arriaga : režissöör ja osatäitja Tommy Lee Jones : operaator Chris Menges : Ameerika Ühendriigid, 2005

  20. The Pitzer-Lee-Kesler-Teja (PLKT) Strategy and Its Implementation by Meta-Computing Software

    Czech Academy of Sciences Publication Activity Database

    Smith, W. R.; Lísal, Martin; Missen, R. W.

    2001-01-01

    Roč. 35, č. 1 (2001), s. 68-73 ISSN 0009-2479 Institutional research plan: CEZ:AV0Z4072921 Keywords : The Pitzer-Lee-Kesler-Teja (PLKT) strategy * implementation Subject RIV: CF - Physical ; Theoretical Chemistry

  1. Behind their eyes : identity in the work of Li-Young Lee and Suji Kwock Kim

    OpenAIRE

    Hand, Meadhbh

    2014-01-01

    The introduction to this study outlines the theoretical framework for comparing the work of Li-Young Lee and Suji Kwock Kim. Using Walter Mignolo's theories about "border thinking," which he outlined in Local Histories/Global Designs, alongside Anzaldua's Borderlands/La Frontera as a basis for approaching Kim's and Lee's work, I demonstrate how the poets may be considered as embodying the role of border thinkers. Marianne Hirsch's definition of "postmemory," is explored, and its relevance to ...

  2. Comparative genomics and stx phage characterization of LEE-negative Shiga toxin-producing Escherichia coli

    Directory of Open Access Journals (Sweden)

    Susan Renee Steyert

    2012-11-01

    Full Text Available Infection by Escherichia coli and Shigella species are among the leading causes of death due to diarrheal disease in the world. Shiga toxin producing Escherichia coli (STEC that do not encode the locus of enterocyte effacement (LEE-negative STEC often possess Shiga toxin gene variants and have been isolated from humans and a variety of animal sources. In this study, we compare the genomes of nine LEE-negative STEC harboring various stx alleles with four complete reference LEE-positive STEC isolates. Compared to a representative collection of prototype E. coli and Shigella isolates representing each of the pathotypes, the whole genome phylogeny demonstrated that these isolates are diverse. Whole genome comparative analysis of the 13 genomes revealed that in addition to the absence of the LEE pathogenicity island, phage encoded genes including non-LEE encoded effectors, were absent from all nine LEE-negative STEC genomes. Several plasmid-encoded virulence factors reportedly identified in LEE-negative STEC isolates were identified in only a subset of the nine LEE-negative isolates further confirming the diversity of this group. In combination with whole genome analysis, we characterized the lambdoid phages harboring the various stx alleles and determined their genomic insertion sites. Although the integrase gene sequence corresponded with genomic location, it was not correlated with stx variant, further highlighting the mosaic nature of these phages. The transcription of these phages in different genomic backgrounds was examined. Expression of the Shiga toxin genes, stx1 and/or stx2, as well as the Q genes, were examined with quantitative reverse transcriptase polymerase chain reaction (qRT-PCR assays. A wide range of basal and induced toxin induction was observed. Overall, this is a first significant foray into the genome space of this unexplored group of emerging and divergent pathogens.

  3. Harvard Forest regional-scale air mass composition by Patterns in Atmospheric Transport History (PATH)

    Science.gov (United States)

    Moody, J. L.; Munger, J. W.; Goldstein, A. H.; Jacob, D. J.; Wofsy, S. C.

    1998-06-01

    We calculated 4 years (1990-1993) of back trajectories arriving at Harvard Forest and used them to define patterns in atmospheric transport history. This information was used to assess the degree to which regional-scale transport modulates the chemical composition of air masses sampled at Harvard Forest. Different seasonal signals in trace-gas concentration are derived for different flow patterns. Throughout the year, high-speed transport of cool, dry, cloud-free air from the north and northwest represents background conditions for the Harvard Forest site. These synoptic conditions describe the atmosphere after passage of a cold front. The most polluted conditions in each season occurred under SW flow, with warmer temperatures, higher water vapor mixing ratios, low mixed-layer depths at the site, and a higher frequency of cloudy conditions. These regional-scale air mass characteristics describe synoptic conditions of warm sector transport. In addition to average air mass characteristics, we have analyzed the covariation of species (e.g., O3 versus NOy-NOx; O3 versus CO) to address chemical processes based on transport history. For summer daytime measurements, we show that relatively fresh pollutants arrive in SW flow while the most aged air masses with higher O3 to NOz slopes arrive with W flow, suggesting a Midwestern contribution to regional high-oxidant episodes. These observations of patterns in chemical characteristics related to patterns in transport are corroborated with probability maps indicating the likelihood of transport from upwind regions using trajectories selected for chemical distribution end-members (10th and 90th percentiles).

  4. "Teaching Physics as one of the humanities": The history of (harvard) project Physics, 1961-1970

    Science.gov (United States)

    Meshoulam, David

    In the United States after World War II, science had come to occupy a central place in the minds of policy makers, scientists, and the public. Negotiating different views between these groups proved a difficult task and spilled into debates over the role and scope of science education. To examine this process, this dissertation traces the history of Harvard Project Physics (HPP), a high-school physics curriculum from the 1960s that incorporated a humanistic and historical approach to teaching science. The narrative begins with the rise of General Education in the 1940s. Under the leadership of Harvard president James Conant, faculty at Harvard developed several Natural Science courses that connected science to history as a way to teach students about science and its relationship to culture. By the late 1950s this historical approach faced resistance from scientists who viewed it as misrepresenting their disciplines and called for students to learn specialized subject matter. With the support of the National Science Foundation (NSF), in the early 1960s scientists' vision of science education emerged in high-school classrooms across the country. By the mid 1960s, with the passage of the Civil Rights Act, the Elementary and Secondary Education Act, and the Daddario Amendment to the NSF, the political and education landscape began to change. These laws transformed the goals of two of the NSF and the Office of Education (USOE). These organizations faced demands to work together to develop projects that would speak to domestic concerns over equity and diversity. Their first joint educational venture was HPP. In order to succeed, HPP had to speak to the needs of disciplinary-minded scientists at the NSF, equity-minded educators at the USOE, and results-focused politicians in Congress. This work argues that HPP succeeded because it met the needs of these various stakeholders regarding the roles of science and education in American society.

  5. La influencia de la Postmodernidad en Orgullo y Prejuicio (1813: Persiguiendo a Jane Austen (2008, Dan Zeff.

    Directory of Open Access Journals (Sweden)

    Irene Romero González

    2012-06-01

    Full Text Available Las novelas de Jane Austen siguen inspirando nuevos relatos cinematográficos pues éstos toman sus historias o sus personajes y los adaptan a contextos culturales y axiológicos actuales de gran diversidad. Es el caso de la novela de Orgullo y Prejuicio de la que se han realizado numerosas adaptaciones clásicas, así como que ha sido objeto de referencia en películas, en trabajos literarios y de adaptaciones postmodernas. Uno de estos trabajos postmodernos es Persiguiendo a Jane Austen una serie inglesa que nos adentra en el mundo de la Regencia a través de las vivencias de una mujer contemporánea que descubre una puerta que comunica ambos mundos y que le permite vivir la historia de Austen bajo la piel de Elizabeth Bennet. A lo largo de este trabajo se realizará un análisis comparado entre esta adaptación postmoderna y su referente literario para comprobar cómo influyen las ideas de la Postmodernidad en un clásico de la literatura decimonónica, pues es una tendencia que nos ayuda a replantearnos un periodo de la historia y a reinterpretar el contexto de la novela original a uno distinto y original.  

  6. Astronomy for Everyone: Harvard's Move Toward an All-Inclusive Astronomy Lab and Telescope

    Science.gov (United States)

    Bieryla, Allyson

    2016-01-01

    Harvard University has a growing astronomy program that offers various courses to the undergraduate concentrators, secondaries and non-majors. Many of the courses involve labs that use the 16-inch DFM Clay Telescope for night-time observations and the heliostat for observing the Sun. The goal is to proactively adapt the lab and telescope facilities to accommodate all students with disabilities. The current focus is converting the labs to accommodate visually impaired students. Using tactile images and sound, the intention is to create an experience equivalent to that of a student with full sight.

  7. Characterization and Comparison of Wine Lees by Liquid Chromatography-Mass Spectrometry in High-Resolution Mode.

    Science.gov (United States)

    Delgado de la Torre, M P; Priego-Capote, F; Luque de Castro, M D

    2015-02-04

    Wine lees from 11 different wineries pertaining to two denominations of origin in Spain (La Rioja and Ribera del Duero) have been characterized in this research by LC-MS/MS in high-resolution mode. For this purpose, the wine lees were separated into the liquid phase (imbibed wine from lees) and the solid residue, which was dried and subjected to solid-liquid extraction assisted by microwaves (dried lees). Both fractions were separately analyzed and the fractions from the 11 wineries compared to find similarity in their patterns. The statistical analysis enabled both differences and common aspects in the composition of imbibed wine from lees and dried lees from all wineries to be found. MS/MS tentative identification of representative compounds in each fraction revealed the varied composition of wine lees with special emphasis on flavonoids such as quercetin, myricetin, and malvidin 3-galactoside, identified in extracts of dried lees, or other compounds such as kaempferol 3-(2',3'-diacetylrhamnoside)-7″-rhamnoside, aminocaproic acid, and citric acid, exclusively identified in imbibed wine from lees. The adsorbent capacity of the solid residue justified the high concentration of phenolic compounds in the extracts from solid lees. The differences found in the composition of the two phases support the separated exploitation of them.

  8. Harvard-MIT research program in short-lived radiopharmaceuticals. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Adelstein, S.J. [Massachusetts Inst. of Tech., Cambridge, MA (United States). Office of Sponsored Programs

    1995-02-01

    The Harvard-MIT Research Program in Short-lived Radiopharmaceuticals was established in 1977 to foster interaction among groups working in radiopharmaceutical chemistry at Harvard Medical School, the Massachusetts Institute of Technology, and the Massachusetts General Hospital. To this was added a group at The Childrens Hospital. From these collaborations and building upon the special strengths of the participating individuals, laboratories and institutions, it was hoped that original approaches would be found for the design of new, clinically useful, radiolabeled compounds. The original thrust of this proposal included: (a) examination of the coordination chemistry of technetium as a basis for rational radiopharmaceutical design, (b) development of an ultrashort-lived radionuclide generator for the diagnosis of congenital heart disease in newborns, (c) synthesis of receptor-site-directed halopharmaceuticals, (d) improved facile labeling of complex molecules with positron-emitting radionuclides. The authors` 1986 proposal was oriented toward organs and disease, emphasizing radiolabeled agents that delineate specific functions and the distribution of receptors in brain, heart, and tumors. In 1989, they further refined their purposes and focused on two major aims: (a) synthesis and utilization of neutral technetium and rhenium complexes of high specific activity, and (b) development of new approaches to the radiolabeling of proteins, peptides, immunoglobulins, and their fragments. In 1992, the authors amended this proposal to concentrate their efforts on biologically active peptides and proteins for targeted radiodiagnosis and therapy.

  9. Harvard-MIT research program in short-lived radiopharmaceuticals. Final report

    International Nuclear Information System (INIS)

    Adelstein, S.J.

    1995-02-01

    The Harvard-MIT Research Program in Short-lived Radiopharmaceuticals was established in 1977 to foster interaction among groups working in radiopharmaceutical chemistry at Harvard Medical School, the Massachusetts Institute of Technology, and the Massachusetts General Hospital. To this was added a group at The Childrens Hospital. From these collaborations and building upon the special strengths of the participating individuals, laboratories and institutions, it was hoped that original approaches would be found for the design of new, clinically useful, radiolabeled compounds. The original thrust of this proposal included: (a) examination of the coordination chemistry of technetium as a basis for rational radiopharmaceutical design, (b) development of an ultrashort-lived radionuclide generator for the diagnosis of congenital heart disease in newborns, (c) synthesis of receptor-site-directed halopharmaceuticals, (d) improved facile labeling of complex molecules with positron-emitting radionuclides. The authors' 1986 proposal was oriented toward organs and disease, emphasizing radiolabeled agents that delineate specific functions and the distribution of receptors in brain, heart, and tumors. In 1989, they further refined their purposes and focused on two major aims: (a) synthesis and utilization of neutral technetium and rhenium complexes of high specific activity, and (b) development of new approaches to the radiolabeling of proteins, peptides, immunoglobulins, and their fragments. In 1992, the authors amended this proposal to concentrate their efforts on biologically active peptides and proteins for targeted radiodiagnosis and therapy

  10. Project PHaEDRA: Preserving Harvard's Early Data and Research in Astronomy

    Science.gov (United States)

    Bouquin, Daina; Frey, Katie; Henneken, Edwin; McEachern, Maria; McGrath, Alex; Guarracino, Daniel; Koch, Jennifer; Damon, James; Brownell, Eric; Smith-Zrull, Lindsay; Daina Bouquin

    2018-01-01

    Material originally produced during 19th and early 20th century by researchers at the Harvard College Observatory (HCO) was recently re-discovered in the HCO Astronomical Plate Stacks collection. This material helps represent the history of the HCO and acts as an irreplaceable primary source on the evolution of observation methods and astronomy as a science. The material is also relevant to the history of women in science as the collection contains logbooks and notebooks produced by the Harvard Computers, women who have come back into the spotlight due to the recent release of books like "The Glass Universe," "Rise of the Rocket Girls," and movies like "Hidden Figures". To ensure that this remarkable set of items is as accessible and useful as possible Wolbach Library, in collaboration with the SAO/NASA Astrophysics Data System (ADS) and others, is working to catalog, digitize, and preserve the entire collection. The material is also being transcribed by volunteers through the Smithsonian Transcription Center in DC. The transcription will allow the collection to be full-text searchable in ADS and for the notebooks to eventually be linked to their original source material: 500,000 glass plate photographs representing the first ever picture of the visible universe. The novel workflow of this distributed repository and the significance of the PHaEDRA collection both stand to support the research of future generations.

  11. Pathology in the new pathway of medical education at Harvard Medical School.

    Science.gov (United States)

    Colvin, R B; Wetzel, M S

    1989-10-01

    In 1985 Harvard Medical School initiated an experimental curriculum that incorporated many of the recommendations of the report on the General Professional Education of the Physician (GPEP). Key features are problem-based small group tutorials that emphasize active learning, with increased independent study time and a decreased number of lectures. Tutors serve as guides to their students and are not necessarily experts in the discipline of the cases studied. Learning skills are taught, including information acquisition and criticism and computer literacy. Knowledge is integrated from the beginning by interdisciplinary basic science courses, by earlier introduction of the clinical sciences, and by juxtaposition of the scientific and humanistic aspects of medicine. Preventive medicine, health maintenance, and ambulatory care are given more attention. The students are organized into societies that provide vertical integration and promote cooperation among students and closer contact with faculty. Pathology has proved to be a popular and key bridge in the new curriculum. The success of the early efforts at Harvard and several pioneering medical schools should encourage others to move toward more problem-solving, student-centered, integrative medical education.

  12. The Harvard case of Xu Xiping: exploitation of the people, scientific advance, or genetic theft?

    Science.gov (United States)

    Sleeboom, Margaret

    2005-04-01

    A unique history and make-up of a population may make it an attractive research target for population geneticists and pharmaco-genomic investors. The promise of pharmaceutical profits and advances in medical knowledge attracted Harvard researchers and the company Millennium Pharmaceuticals to remote areas in Anhui Province, Central China, leading to international diplomatic disagreements about issues such as the ownership of genetic material and informed consent (IC). This article discusses the role of genomics and genetic sampling in China, the way it is related to population policies (the new eugenics), the national importance of genetic materials and the conflicts it led to between the Chinese government and Harvard University. Here many consider the Xu Xiping case as textbook example of ruthless Western exploitation of development countries, illustrating the cold rationality of science in the process of globalisation. Ten perspectives on this case show that this view is simplistic and contributes little to an understanding of bioethical issues important to the population actually donating the samples. Viewing the Xu Xiping case as the nexus of the intertwinement of international, transnational, national, and local interest groups shows how different interest groups make use of different units of analysis. It also clarifies why the same practice of genetic sampling continues under a different regime, and why the discussion about genetic sampling has shifted from a concern with health care of the poor to an issue of international exploitation, terrorism and development.

  13. Gender Anarchy as Social Justice: An Analytic Reconstruction of the Idea of Epistemic Equality in Jane Roland Martin's "Reclaiming a Conversation"

    Science.gov (United States)

    Seals, Greg

    2006-01-01

    Jane Roland Martin's later work, especially as represented in "The Schoolhome: Rethinking Schools for Changing Families," has been attacked as vague, essentialistic, and a formula for the (re)feminization of education. This paper does not attempt to defend Martin against these criticisms because such a defense seems impossible for…

  14. Pride and prejudice and zombies: The classic Regency romance—Now with ultraviolent zombie mayhem!, by Jane Austen and Seth Grahame-Smith [book review

    Directory of Open Access Journals (Sweden)

    Craig B. Jacobsen

    2009-11-01

    Full Text Available Review of Jane Austen and Seth Grahame-Smith. Pride and prejudice and zombies: The classic Regency romance—Now with ultraviolent zombie mayhem! Philadelphia, PA: Quirk Books, 2009. $12.95 (320p ISBN 978-1594743344.

  15. Lee-Yang zeros and large-deviation statistics of a molecular zipper

    Science.gov (United States)

    Deger, Aydin; Brandner, Kay; Flindt, Christian

    2018-01-01

    The complex zeros of partition functions were originally investigated by Lee and Yang to explain the behavior of condensing gases. Since then, Lee-Yang zeros have become a powerful tool to describe phase transitions in interacting systems. Today, Lee-Yang zeros are no longer just a theoretical concept; they have been determined in recent experiments. In one approach, the Lee-Yang zeros are extracted from the high cumulants of thermodynamic observables at finite size. Here we employ this method to investigate a phase transition in a molecular zipper. From the energy fluctuations in small zippers, we can predict the temperature at which a phase transition occurs in the thermodynamic limit. Even when the system does not undergo a sharp transition, the Lee-Yang zeros carry important information about the large-deviation statistics and its symmetry properties. Our work suggests an interesting duality between fluctuations in small systems and their phase behavior in the thermodynamic limit. These predictions may be tested in future experiments.

  16. Utilization of a factorial design to study the composting of hydrolyzed grape marc and vinification lees.

    Science.gov (United States)

    Paradelo, Remigio; Moldes, Ana B; Barral, María T

    2010-03-10

    Hydrolyzed grape marc (HGM) is the solid residue generated after the acid hydrolysis of grape marc to obtain hemicellulosic sugars for biotechnological purposes. In this work, HGM containing cellulose and lignin was composted together with vinification lees to obtain plant substrates on a laboratory scale. The effects of temperature (in the range of 20-50 degrees C), concentration of vinification lees (5-100 g/100 g of hydrolyzed grape marc), and concentration of CaCO(3) on the final properties of the composted HGM were studied by means of an experimental plan with factorial structure. The interrelationship between dependent and operational variables was established by models including linear, interaction, and quadratic terms. The most influential variable on the C/N ratio and P, K and Mg contents of composted substrates was the vinification lees concentration followed by the temperature, whereas on Na content and electrical conductivity the most influential variable was the temperature followed by the vinification lees concentration. The results of the incubation experiments indicated that optimal conditions for obtaining plant substrates can be achieved by composting 1:1 mixtures of hydrolyzed grape marc and vinification lees, in the presence of 5 g of CaCO(3)/100 g of HGM. During composting the pH of the mixtures increased from 5.1-6.7 to 7.1-8.1, salinity and water-soluble carbon were reduced in most cases, and the initial phytotoxicity disappeared in all of the mixtures tested.

  17. Practicing psychology in the art gallery: Vernon Lee's aesthetics of empathy.

    Science.gov (United States)

    Lanzoni, Susan

    2009-01-01

    Late nineteenth-century psychologists and aestheticians were fascinated by the study of psychological and physiological aspects of aesthetic response, and the British intellectual and aesthete Vernon Lee was a major participant in this venture. Working outside the academy, Lee conducted informal experiments with Clementina Anstruther-Thomson, recording changes in respiration, balance, emotion, and body movements in response to aesthetic form. In fashioning her aesthetics of empathy, she mined a wealth of psychological theories of the period including motor theories of mind, physiological theories of emotion, evolutionary models of the usefulness of art, and, most prominently, the empathic projection of feeling and movement into form. Lee distributed questionnaires, contributed to scientific journals, carried out her own introspective studies, and debated aesthetics with leading psychologists. This paper critiques the prevailing view of Lee's aesthetics as a displaced sign of her gender or sexuality, and questions her status as simply an amateur in the field of psychology. Instead, I argue that Lee's empirically based empathy theory of art was a significant contribution to debates on psychological aesthetics at the outset of the twentieth century, offering a synthesis of Lipps's mentalistic Einfühlung and sensation-based imitation theories of aesthetic response.

  18. Expression Regulation of Polycistronic lee3 Genes of Enterohaemorrhagic Escherichia coli.

    Directory of Open Access Journals (Sweden)

    Wei-Sheng W Sun

    Full Text Available Enterohaemorrhagic Escherichia coli O157:H7 (EHEC carries a pathogenic island LEE that is consisted mainly of five polycistronic operons. In the lee3 operon, mpc is the first gene and has been reported to down regulate the type-3 secretion system of EHEC when its gene product is over-expressed. Furthermore, mpc has been suggested to have a regulation function via translation but the mechanism remains unclear. To clarify this hypothesis, we dissected the polycistron and examined the translated products. We conclude that translation of mpc detrimentally governs the translation of the second gene, escV, which in turn affects the translation of the third gene, escN. Then sequentially, escN affects the expression of the downstream genes. Furthermore, we located a critical cis element within the mpc open-reading frame that plays a negative role in the translation-dependent regulation of lee3. Using qRT-PCR, we found that the amount of mpc RNA transcript present in EHEC was relatively limited when compared to any other genes within lee3. Taken together, when the transcription of LEE is activated, expression of mpc is tightly controlled by a restriction of the RNA transcript of mpc, translation of which is then critical for the efficient production of the operon's downstream gene products.

  19. [Lee Jungsook, a Korean independence activist and a nurse during the Japanese colonial period].

    Science.gov (United States)

    Kim, Sook Young

    2015-04-01

    This article examines the life of Lee Jungsook, a Korean nurse, as a independence activist during the Japanese colonial period. Lee Jungsook(1896-1950) was born in Bukchung in Hamnam province. She studied at Chungshin girl's high school and worked at Severance hospital. The characteristics and culture of her educational background and work place were very important factors which influenced greatly the life of Lee Jungsook. She learned independent spirit and nationalism from Chungshin girls' high school and worked as nurse at the Severance hospital which were full of intense aspiration for Korea's independence. Many of doctors, professors and medical students were participated in the 3.1 Independence Movement. Lee Jungsook was a founding member of Hyulsungdan who tried to help the independence activists in prison and their families and worked as a main member of Korean Women's Association for Korean Independece and Kyungsung branch of the Korean Red Cross. She was sent to jail by the Japanese government for her independence activism. After being released after serving two years confinement, she worked for the Union for Women's Liberation as a founding member. Lee Joungsook was a great independence activist who had a nursing care spirit as a nurse.

  20. A distributed model: redefining a robust research subject advocacy program at the Harvard Clinical and Translational Science Center.

    Science.gov (United States)

    Winkler, Sabune J; Cagliero, Enrico; Witte, Elizabeth; Bierer, Barbara E

    2014-08-01

    The Harvard Clinical and Translational Science Center ("Harvard Catalyst") Research Subject Advocacy (RSA) Program has reengineered subject advocacy, distributing the delivery of advocacy functions through a multi-institutional, central platform rather than vesting these roles and responsibilities in a single individual functioning as a subject advocate. The program is process-oriented and output-driven, drawing on the strengths of participating institutions to engage local stakeholders both in the protection of research subjects and in advocacy for subjects' rights. The program engages stakeholder communities in the collaborative development and distributed delivery of accessible and applicable educational programming and resources. The Harvard Catalyst RSA Program identifies, develops, and supports the sharing and distribution of expertise, education, and resources for the benefit of all institutions, with a particular focus on the frontline: research subjects, researchers, research coordinators, and research nurses. © 2014 Wiley Periodicals, Inc.

  1. Maxwell Fry and Jane Drew Partners : The Contributions of British Architects to Built Environment in Colonial Nigeria, 1946-1959

    Directory of Open Access Journals (Sweden)

    Abiodun Akeem Oladiti

    2016-06-01

    Full Text Available This paper examines the contributions of two British architects, Maxwell Fry and Jane Drew in the development of built environment in Nigeria after World War II. It analyses the historical development of the built environment in Nigeria’s public space with respect to modernize infrastructures such as banks, schools, teachers training colleges and the university needed in support of the colonial administration in Nigeria. The agitation of the nationalists and postwar reconstruction facilitated and encouraged the British Empire to develop the edifice or structures that would be suitable for the environment. This, to a large extent, influenced the Nigerian architecture and built environment. Their design principles yielded functional institutional spaces and a hybrid aesthetics that signifies modernist construction and colonial influence. The paper concludes that the designs of both Fry and Drew represent a milestone and significant contribution to the development of built environment in colonial Nigeria.

  2. La economía de las relaciones de género en "Orgullo y prejuicio" de Jane Austen

    Directory of Open Access Journals (Sweden)

    Sonia Herrera Sánchez

    2013-01-01

    Full Text Available El presente artículo pretende ser una aproximación con gafas de género a los sistemas de transmisión o ruptura del patriarcado a través de una de las obras más conocidas de la literatura inglesa de principios del siglo XIX: Orgullo y prejuicio, de Jane Austen. Para ello, se desentrañará el funcionamiento de la economía de género en la mencionada novela, confrontándolo con los procesos educativos de la época y los primeros indicios de individualización femenina en la sociedad moderna.

  3. Connecting the Plots: The Extension of Return and Korean Ethnic Nationalism in Jane Jeong Trenka’s 'Fugitive Visions'

    Directory of Open Access Journals (Sweden)

    Ethan Waddell

    2017-05-01

    Full Text Available Thousands of overseas Korean adoptees return to Korea temporarily each year in search of their true origin, but few choose to stay permanently. A prominent member of this small community is Jane Jeong Trenka, author of two memoirs: The Language of Blood (2003 and Fugitive Visions: An Adoptee’s Return to Korea (2009. This article analyses Trenka’s literary struggle for permanence in Fugitive Visions through theories on Korean ethnic national identity. Using Marshall McLuhan’s idea of media as the ‘extension of man’, it explores the symbiotic relationship between literary media and identity, connecting colonial-era writings on Korean ethnic nationalism to Trenka’s portrayal of transnational return.

  4. La economía de las relaciones de género en "Orgullo y prejuicio" de Jane Austen

    OpenAIRE

    Sonia Herrera Sánchez

    2013-01-01

    El presente artículo pretende ser una aproximación con gafas de género a los sistemas de transmisión o ruptura del patriarcado a través de una de las obras más conocidas de la literatura inglesa de principios del siglo XIX: Orgullo y prejuicio, de Jane Austen. Para ello, se desentrañará el funcionamiento de la economía de género en la mencionada novela, confrontándolo con los procesos educativos de la época y los primeros indicios de individualización femenina en la sociedad moderna....

  5. Duke Power's William Lee says INPO's purpose is solving industry problems, not educating the public

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    Former Institute of Nuclear Power Operations (INPO) head, William Lee thinks that nuclear critics could misuse institute reports on investigations of nuclear plant construction and operation. If so, that would outweigh any public relations benefits of using the reports to inform and educate the public. Lee thinks the best way to gain public confidence is for the industry to perform well. The four-year-old institute was originally formed to improve operations, but recent problems with unfinished plants led to a system of construction audits. By offering guidance to companies building nuclear plants, INPO is meeting competition from utilities such as Duke Power, which is now marketing its expertise in designing and building plants. Lee emphasizes the importance of asking the right questions that will lead to quality control

  6. Practical Improvements to the Lee-More Conductivity Near the Metal-Insulator Transition

    International Nuclear Information System (INIS)

    Desjarlais, Michael P.

    2000-01-01

    The wide-range conductivity model of Lee and More is modified to allow better agreement with recent experimental data and theories for dense plasmas in the metal-insulator transition regime. Modifications primarily include a new ionization equilibrium model, consisting of a smooth blend between single ionization Saha (with a pressure ionization correction) and the generic Thomas-Fermi ionization equilibrium, a more accurate treatment of electron-neutral collisions using a polarization potential, and an empirical modification to the minimum allowed collision time. These simple modifications to the Lee-More algorithm permit a more accurate modeling of the physics near the metal-insulator transition, while preserving the generic Lee-More results elsewhere

  7. Practical improvements to the Lee-More conductivity near the metal-insulator transition

    International Nuclear Information System (INIS)

    Desjarlais, M.P.

    2001-01-01

    The wide-range conductivity model of Lee and More is modified to allow better agreement with recent experimental data and theories for dense plasmas in the metal-insulator transition regime. Modifications primarily include a new ionization equilibrium model, consisting of a smooth blend between single ionization Saha (with a pressure ionization correction) and the generic Thomas-Fermi ionization equilibrium, a more accurate treatment of electron-neutral collisions using a polarization potential, and an empirical modification to the minimum allowed collision time. These simple modifications to the Lee-More algorithm permit a more accurate modeling of the physics near the metal-insulator transition, while preserving the generic Lee-More results elsewhere. (orig.)

  8. Secretion of flagellin by the LEE-encoded type III secretion system of enteropathogenic Escherichia coli

    Directory of Open Access Journals (Sweden)

    Kaparakis Maria

    2009-02-01

    Full Text Available Abstract Background Enteropathogenic Escherichia coli (EPEC is an attaching and effacing (A/E pathogen that possesses a type III secretion system (T3SS encoded within the locus of enterocyte effacement (LEE. The LEE is essential for A/E lesion formation and directs the secretion and translocation of multiple LEE-encoded and non-LEE encoded effector proteins into the cytosol of infected cells. In this study we used proteomics to compare proteins exported to the culture supernatant by wild type EPEC E2348/69, a ΔespADB mutant and a ΔescF T3SS mutant. Results We observed that flagellin was consistently and strongly present in the secretome of wild type EPEC and the ΔespADB mutant but present only weakly in the secretome of the ΔescF mutant. Given the ancestral relationship between the flagella export apparatus and virulence associated T3SSs, we investigated whether FliC could utilise the LEE-encoded T3SS for export. In the absence of a functional flagella export apparatus, we showed that FliC could be secreted by the LEE-encoded T3SS and stimulate (Toll-like receptor 5 TLR5 signalling but could not confer motility. Conclusion Since the secretion of FliC during A/E lesion formation would presumably be disadvantageous for the pathogen, we propose that virulence associated T3SSs and flagella T3SSs have evolved through a system of chaperones and complex regulatory pathways to be functional at different times to ensure that FliC secretion does not occur during T3SS effector translocation.

  9. Secretion of flagellin by the LEE-encoded type III secretion system of enteropathogenic Escherichia coli.

    Science.gov (United States)

    Badea, Luminita; Beatson, Scott A; Kaparakis, Maria; Ferrero, Richard L; Hartland, Elizabeth L

    2009-02-06

    Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) pathogen that possesses a type III secretion system (T3SS) encoded within the locus of enterocyte effacement (LEE). The LEE is essential for A/E lesion formation and directs the secretion and translocation of multiple LEE-encoded and non-LEE encoded effector proteins into the cytosol of infected cells. In this study we used proteomics to compare proteins exported to the culture supernatant by wild type EPEC E2348/69, a DeltaespADB mutant and a DeltaescF T3SS mutant. We observed that flagellin was consistently and strongly present in the secretome of wild type EPEC and the DeltaespADB mutant but present only weakly in the secretome of the DeltaescF mutant. Given the ancestral relationship between the flagella export apparatus and virulence associated T3SSs, we investigated whether FliC could utilise the LEE-encoded T3SS for export. In the absence of a functional flagella export apparatus, we showed that FliC could be secreted by the LEE-encoded T3SS and stimulate (Toll-like receptor 5) TLR5 signalling but could not confer motility. Since the secretion of FliC during A/E lesion formation would presumably be disadvantageous for the pathogen, we propose that virulence associated T3SSs and flagella T3SSs have evolved through a system of chaperones and complex regulatory pathways to be functional at different times to ensure that FliC secretion does not occur during T3SS effector translocation.

  10. In Pursuit of Educational Integrity: Professional Identity Formation in the Harvard Medical School Cambridge Integrated Clerkship.

    Science.gov (United States)

    Gaufberg, Elizabeth; Bor, David; Dinardo, Perry; Krupat, Edward; Pine, Elizabeth; Ogur, Barbara; Hirsh, David A

    2017-01-01

    Graduates of Harvard Medical School's Cambridge Integrated Clerkship (CIC) describe several core processes that may underlie professional identity formation (PIF): encouragement to integrate pre-professional and professional identities; support for learner autonomy in discovering meaningful roles and responsibilities; learning through caring relationships; and a curriculum and an institutional culture that make values explicit. The authors suggest that the benefits of educational integrity accrue when idealistic learners inhabit an educational model that aligns with their own core values, and when professional development occurs in the context of an institutional home that upholds these values. Medical educators should clarify and animate principles within curricula and learning environments explicitly in order to support the professional identity formation of their learners.

  11. Adaptation of Harvard Trauma questionnaire for working with refugees and asylum seekers in Serbia

    Directory of Open Access Journals (Sweden)

    Vukčević Maša

    2016-01-01

    Full Text Available The number of refugees and asylum seekers in Serbia is significantly increasing. Many have experienced traumatic events and suffer from posttraumatic stress disorder and depression. In order to provide them with adequate assistance, caregivers need adjusted assessment tools. The main goal of this research was the adaptation of the Harvard Trauma Questionnaire for working with refugees and asylum seekers in Serbia. A total of 16 focus groups were interviewed in two phases in order to create an adequate list of traumatic events for this population. The adapted list was subsequently administered to 226 persons seeking asylum in Serbia, along with the remaining parts of HTQ, HSCL-25 and BDI-II. Results show that the adapted list of traumatic events, as well as a shorter version, has good validity and other metric properties. The adaptation of the first assessment tool for working with refugees and asylum seekers in Serbia has significant practical implications.

  12. The Sociology of the Deceased Harvard Medical Unit at Boston City Hospital.

    Science.gov (United States)

    Tishler, Peter V

    2015-12-01

    Many graduates of the Harvard Medical Unit (HMU) at Boston City Hospital, in either the clinical training/residency program or the research program at the Thorndike Memorial Laboratory, contributed in major ways to the HMU and constantly relived their HMU experiences. The HMU staff physicians, descending from founder and mentor physicians Francis W. Peabody, Soma Weiss, and George R. Minot, were dedicated to the teaching, development, and leadership of its clinical and research trainees, whose confidence and dedication to patient care as a result of their mentorship led many to lifelong achievements as clinicians, teachers, and mentors. Their experience also led to a lifelong love of the HMU (despite its loss), camaraderie, happiness, and intense friendships with their associates.

  13. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study

    Science.gov (United States)

    Ding, Hongliu; Sarokhan, Alison K.; Roderick, Sarah S.; Bakshi, Rachit; Maher, Nancy E.; Ashourian, Paymon; Kan, Caroline G.; Chang, Sunny; Santarlasci, Andrea; Swords, Kyleen E.; Ravina, Bernard M.; Hayes, Michael T.; Sohur, U. Shivraj; Wills, Anne-Marie; Flaherty, Alice W.; Unni, Vivek K.; Hung, Albert Y.; Selkoe, Dennis J.; Schwarzschild, Michael A.; Schlossmacher, Michael G.; Sudarsky, Lewis R.; Growdon, John H.; Ivinson, Adrian J.; Hyman, Bradley T.; Scherzer, Clemens R.

    2011-01-01

    Background Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson’s disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods Here we genotyped a prioritized non-coding variant in SNCA intron-4 in 344 patients with Parkinson’s and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio = 1.40, P value = 0.0032). Conclusions This result increases confidence in the notion that in many clinically well-characterized patients genetic variation in SNCA contributes to “sporadic” disease. PMID:21953863

  14. Synchronization and anti-synchronization coexist in Chen-Lee chaotic systems

    International Nuclear Information System (INIS)

    Chen, J.-H.; Chen, H.-K.; Lin, Y.-K.

    2009-01-01

    This study demonstrates that synchronization and anti-synchronization can coexist in Chen-Lee chaotic systems by direct linear coupling. Based on Lyapunov's direct method, a linear controller was designed to assure that two different types of synchronization can simultaneously be achieved. Further, the hybrid projective synchronization of Chen-Lee chaotic systems was studied using a nonlinear control scheme. The nonlinear controller was designed according to the Lyapunov stability theory to guarantee the hybrid projective synchronization, including synchronization, anti-synchronization, and projective synchronization. Finally, numerical examples are presented in order to illustrate the proposed synchronization approach.

  15. Deterministic and stochastic trends in the Lee-Carter mortality model

    DEFF Research Database (Denmark)

    Callot, Laurent; Haldrup, Niels; Kallestrup-Lamb, Malene

    2015-01-01

    The Lee and Carter (1992) model assumes that the deterministic and stochastic time series dynamics load with identical weights when describing the development of age-specific mortality rates. Effectively this means that the main characteristics of the model simplify to a random walk model with age...... mortality data. We find empirical evidence that this feature of the Lee–Carter model overly restricts the system dynamics and we suggest to separate the deterministic and stochastic time series components at the benefit of improved fit and forecasting performance. In fact, we find that the classical Lee...

  16. Deterministic and stochastic trends in the Lee-Carter mortality model

    DEFF Research Database (Denmark)

    Callot, Laurent; Haldrup, Niels; Kallestrup-Lamb, Malene

    The Lee and Carter (1992) model assumes that the deterministic and stochastic time series dynamics loads with identical weights when describing the development of age specific mortality rates. Effectively this means that the main characteristics of the model simplifies to a random walk model...... that characterizes mortality data. We find empirical evidence that this feature of the Lee-Carter model overly restricts the system dynamics and we suggest to separate the deterministic and stochastic time series components at the benefit of improved fit and forecasting performance. In fact, we find...

  17. Still Having Her Say: More than a Decade after Becoming a Household Name, Harvard Law Professor Lani Guinier Holds True to Her Beliefs, Principles

    Science.gov (United States)

    Roach, Ronald

    2004-01-01

    This article describes the accomplishments of Lani Guinier, Bennett Boskey Professor of Law at Harvard University law school. The first and only African American woman to hold a tenured faculty position at the Harvard University law school, Guinier has put her visibility to use by speaking out on issues of race, gender and democratic…

  18. What the Butler Saw: Lee Daniels's Studies in Biography and History

    Science.gov (United States)

    Beck, Bernard

    2014-01-01

    The movie "Lee Daniels' The Butler" is an example of a work that is meant not only to entertain but to convey an important attitude and offer important viewpoints. The movie deals with a deep issue in the history of movies and the history of the country: racial inequality. Three issues are discussed in this article: (a) African…

  19. Optimization Evaluation: Lee Chemical Superfund Site, City Of Liberty, Clay County, Missouri

    Science.gov (United States)

    The Lee Chemical Superfund Site (site) is located along Missouri Highway 210 in Liberty, Missouri, approximately 15 miles east of Kansas City, Missouri. Currently, the site is a vacant lot of approximately2.5 acres in a flat alluvial plain.

  20. Forecasting selected specific age mortality rate of Malaysia by using Lee-Carter model

    Science.gov (United States)

    Shukri Kamaruddin, Halim; Ismail, Noriszura

    2018-03-01

    Observing mortality pattern and trend is an important subject for any country to maintain a good social-economy in the next projection years. The declining in mortality trend gives a good impression of what a government has done towards macro citizen in one nation. Selecting a particular mortality model can be a tricky based on the approached method adapting. Lee-Carter model is adapted because of its simplicity and reliability of the outcome results with approach of regression. Implementation of Lee-Carter in finding a fitted model and hence its projection has been used worldwide in most of mortality research in developed countries. This paper studies the mortality pattern of Malaysia in the past by using original model of Lee-Carter (1992) and hence its cross-sectional observation for a single age. The data is indexed by age of death and year of death from 1984 to 2012, in which are supplied by Department of Statistics Malaysia. The results are modelled by using RStudio and the keen analysis will focus on the trend and projection of mortality rate and age specific mortality rate in the future. This paper can be extended to different variants extensions of Lee-Carter or any stochastic mortality tool by using Malaysia mortality experience as a centre of the main issue.

  1. INCA Modelling of the Lee System: strategies for the reduction of nitrogen loads

    Science.gov (United States)

    Flynn, N. J.; Paddison, T.; Whitehead, P. G.

    The Integrated Nitrogen Catchment model (INCA) was applied successfully to simulate nitrogen concentrations in the River Lee, a northern tributary of the River Thames for 1995-1999. Leaching from urban and agricultural areas was found to control nitrogen dynamics in reaches unaffected by effluent discharges and abstractions; the occurrence of minimal flows resulted in an upward trend in nitrate concentration. Sewage treatment works (STW) discharging into the River Lee raised nitrate concentrations substantially, a problem which was compounded by abstractions in the Lower Lee. The average concentration of nitrate (NO3) for the simulation period 1995-96 was 7.87 mg N l-1. Ammonium (NH4) concentrations were simulated less successfully. However, concentrations of ammonium rarely rose to levels which would be of environmental concern. Scenarios were run through INCA to assess strategies for the reduction of nitrate concentrations in the catchment. The conversion of arable land to ungrazed vegetation or to woodland would reduce nitrate concentrations substantially, whilst inclusion of riparian buffer strips would be unsuccessful in reducing nitrate loading. A 50% reduction in nitrate loading from Luton STW would result in a fall of up to 5 mg N l-1 in the reach directly affected (concentrations fell from maxima of 13 to 8 mg N l-1 , nearly a 40 % reduction), whilst a 20% reduction in abstractions would reduce maximum peaks in concentration in the lower Lee by up to 4 mg l-1 (from 17 to 13 mg N l-1, nearly a 25 % reduction),.

  2. Servicing the first web server - Tim Berners-Lee's NeXT

    CERN Multimedia

    unknown, Association aBCM

    2009-01-01

    In August 2009 a team from the Association aBCM in Lausanne came to CERN to give the world's first web server a health check under the watchful eye of web pioneer Robert Cailliau. They took an image of the hard drive at this time, copies of which were given to Robert Cailliau and Tim Berners-Lee.

  3. Charcot, Mitchell and Lees: neurology free thinkers and their experiences of psychoactive drugs

    Directory of Open Access Journals (Sweden)

    Hélio A. G. Teive

    Full Text Available ABSTRACT Three world-famous neurologists, Charcot and Mitchell, in the 19th century, and Lees, in this century, all of whom had great scientific curiosity, experimented with the psychoactive drugs hashish, mescal and yagé, respectively, in an attempt to increase their knowledge of neurological diseases and how the brain works.

  4. Yang-Lee edge singularity on a class of tree-like lattices

    Energy Technology Data Exchange (ETDEWEB)

    Knezevic, Milan; Elezovic-Hadzic, Suncica [Faculty of Physics, University of Belgrade, Belgrade (Yugoslavia)

    1997-03-21

    The density of zeros of the partition function of the Ising model on a class of tree-like lattices is studied. An exact closed-form expression for the pertinent critical exponents is derived by using a couple of recursion relations which have a singular behaviour near the Yang-Lee edge. (author)

  5. Fighting with Reality: Considering Mark Johnson's Pragmatic Realism through Bruce Lee's Jeet Kune Do Method

    Science.gov (United States)

    Miller, Alexander David

    2015-01-01

    This dissertation considers the supportive and complementary relation between Mark Johnson's embodied realism and Bruce Lee's Jeet Kune Do as a philosophical practice. In exploring this relationship, the emphasis on one's embodiment condition and its relationship with metaphor and self-expression are the primary focus. First, this work involves…

  6. Lee-side flow structures of very low aspect ratio cruciform wing–body configurations

    CSIR Research Space (South Africa)

    Tuling, S

    2013-12-01

    Full Text Available OF SPACECRAFT AND ROCKETS Vol. 50, No. 6, November–December 2013 Lee-Side Flow Structures of Very Low Aspect Ratio Cruciform Wing–Body Configurations S. Tuling∗ Council for Scientific and Industrial Research, Pretoria 0001, South Africa L. Dala...

  7. Thomas George Lee - Implantation and early development of North American rodents

    DEFF Research Database (Denmark)

    Carter, Anthony Michael

    2011-01-01

    A century ago Thomas G. Lee amassed an unparalleled collection of developmental series of North American rodents such as the thirteen-lined ground squirrel, the Plains pocket gopher and Merriam's kangaroo rat. He was the first to describe the initial attachment of the squirrel blastocyst...

  8. “What’s Next?” Jasper Fforde’s Attempts on Jane Eyre  « What’s Next ? » Quand Jasper Fforde s’attaque à Jane Eyre

    Directory of Open Access Journals (Sweden)

    Wolfgang Funk

    2010-03-01

    Full Text Available This article attempts to analyse the interplay of Jane Eyre with one of its most daring re-appropriations, Jasper Fforde’s 2001 novel The Eyre Affair, which will be presented as a ‘parallolotopia’ in this essay. The main focus is on the inter-textual relationship between the two texts and the interplay and entanglement of the two novels will be analysed as a particular form of post-modern pastiche (in the sense of Fredric Jameson, the main characteristic of which is its self-reflective attitude. This pastiche does not only disestablish traditional role allocations in the framework of literary communication (such as author, story and reader, it also might serve as a completely new paradigm in the relation of literature and its perception, who which (as the article attempts to point out will be grounded in an ‘aesthetics of insolence’ rather than one of diffidence, as was traditionally the case.Cet article entend analyser l’interaction entre Jane Eyre et l’une de ses réécritures les plus audacieuses, celle du roman The Eyre Affair de Jasper Fforde (2001, qui sera présenté comme un « parallélotope ». Il s’agit de se concentrer essentiellement sur la relation intertextuelle entre les deux textes ; l’interaction et l’imbrication des deux romans seront étudiées comme une forme particulière de pastiche postmoderne (selon la définition de Fredric Jameson, dont la caractéristique principale est l’attitude auto-réflexive. Ce pastiche ne déstabilise pas seulement les attributions traditionnelles de rôles dans le cadre de la communication littéraire (auteur, intrigue, lecteur, il pourrait servir également de paradigme absolument nouveau en matière de lien entre la littérature et la manière dont elle est perçue, qui, comme le souligne l’article, sera fondé sur une « esthétique de l’insolence » plutôt que sur celle de la méfiance, comme c’est habituellement le cas.

  9. Co-ordinate single-cell expression of LEE4- and LEE5-encoded proteins of Escherichia coli O157:H7.

    Science.gov (United States)

    Roe, Andrew J; Naylor, Stuart W; Spears, Kevin J; Yull, Helen M; Dransfield, Tracy A; Oxford, Matthew; McKendrick, Iain J; Porter, Megan; Woodward, Martin J; Smith, David G E; Gally, David L

    2004-10-01

    Escherichia coli O157:H7 is a zoonotic pathogen that can express a type III secretion system (TTSS) considered important for colonization and persistence in ruminants. E. coli O157:H7 strains have been shown to vary markedly in levels of protein secreted using the TTSS and this study has confirmed that a high secretion phenotype is more prevalent among isolates associated with human disease than isolates shed by healthy cattle. The variation in secretion levels is a consequence of heterogeneous expression, being dependent on the proportion of bacteria in a population that are actively engaged in protein secretion. This was demonstrated by indirect immunofluorescence and eGFP fusions that examined the expression of locus of enterocyte effacement (LEE)-encoded factors in individual bacteria. In liquid media, the expression of EspA, tir::egfp, intimin, but not map::egfp were co-ordinated in a subpopulation of bacteria. In contrast to E. coli O157:H7, expression of tir::egfp in EPEC E2348/69 was equivalent in all bacteria although the same fusion exhibited variable expression when transformed into an E. coli O157:H7 background. An E. coli O157:H7 strain deleted for the LEE demonstrated weak but variable expression of tir::egfp indicating that the elements controlling the heterogeneous expression lie outside the LEE. The research also demonstrated the rapid induction of tir::egfp and map::egfp on contact with bovine epithelial cells. This control in E. coli O157:H7 may be required to limit exposure of key surface antigens, EspA, Tir and intimin during colonization of cattle but allow their rapid production on contact with bovine gastrointestinal epithelium at the terminal rectum.

  10. The medical theory of Lee Je-ma and its character

    Directory of Open Access Journals (Sweden)

    LEE Kyung-Lock

    2005-12-01

    Full Text Available Lee Je-ma(李濟馬, 1837-1900 was a prominent scholar as well as an Korean physician He classified every people into four distinctive types: greater yang[tai yang] person, lesser yin[shao yin] person greater yin[tai yin] person, lesser yin[shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features Using these four types he created The Medical Science of Four Types(四象體質論.This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being(人間觀 underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body(人體論 is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy According to Lee Je-Ma's theory of human being human is an equal individual in a modern way of thinking not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body.The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body(心身二元論' that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

  11. Proton beam dosimetry for radiosurgery: implementation of the ICRU Report 59 at the Harvard Cyclotron Laboratory

    International Nuclear Information System (INIS)

    Newhauser, Wayne D.; Myers, Karla D.; Rosenthal, Stanley J.; Smith, Alfred R.

    2002-01-01

    Recent proton dosimetry intercomparisons have demonstrated that the adoption of a common protocol, e.g. ICRU Report 59, can lead to improved consistency in absorbed dose determinations. We compared absorbed dose values, measured in the 160 MeV proton radiosurgery beamline at the Harvard Cyclotron Laboratory, based on ionization chamber methods with those from a Faraday cup technique. The Faraday cup method is based on a proton fluence determination that allows the estimation of absorbed dose with the CEMA approximation, under which the dose is equal to the fluence times the mean mass stopping power. The ionization chamber technique employs an air-kerma calibration coefficient for 60 Co radiation and a calculated correction in order to take into account the differences in response to 60 Co and proton beam radiations. The absorbed dose to water, based on a diode measurement calibrated with a Faraday cup technique, is approximately 2% higher than was obtained from an ionization chamber measurement. At the Bragg peak depth, the techniques agree to within their respective uncertainties, which are both approximately 4% (1 standard deviation). The ionization chamber technique exhibited superior reproducibility and was adopted in our standard clinical practice for radiosurgery. (author)

  12. A phase-I clinical trial for cranial BNCT at Harvard-MIT

    International Nuclear Information System (INIS)

    Busse, P.M.; Palmer, M.R.; Harling, O.K.

    2000-01-01

    Phase I trial designed to determine the maximum tolerable dose to normal tissue for cranial BNCT (Boron Neutron Capture Therapy) irradiations was recently completed at Harvard Medical School and MIT. Twenty-two subjects diagnosed with either glioblastoma multiforme or intracranial melanoma were treated between 1996 and 1999. Subjects received either one or two administrations of boronophenylalanine intravenously at doses between 250 and 350 mg/kg body weight, then exposed in one, two or three fields to epithermal neutrons at the MIT Research Reactor in one or two fractions. Over the course of the study, the maximum normal tissue dose target was increased from 8.8 to 14.2 RBE (Relative Biological Effectiveness) Gy in 10% increments. Subjects have been followed clinically and radiographically. Of those patients surviving beyond six months, no MRI (Magnetic Resonance Image) white-matter changes were observed and no long-term complications attributable to BNCT were evident. Tumor responses were observed, particularly with the melanoma subjects. With increasing doses, difficulties arose from long irradiation times (approximately 3 hours) and the emergence of acute reactions in the skin and mucosa. The trial was stopped in May 1999. Future trials will be initiated with the new high intensity, low background fission converter beam at MIT. (author)

  13. Clinical treatment planning for subjects undergoing boron neutron capture therapy at Harvard-MIT

    International Nuclear Information System (INIS)

    Zamenhof, R.G.; Palmer, M.R.; Buse, P.M.

    2001-01-01

    Treatment planning is a crucial component of the Harvard-MIT boron neutron capture therapy (BNCT) clinical trials. Treatment planning can be divided into five stages: (1) pre-planning, based on CT and MRI scans obtained when the subject arrives at the hospital and on assumed boron-10 distribution parameters; (2) subject set-up, or simulation, in the MITR-II medical therapy room to determine the boundary conditions for possible set-up configurations; (3) re-planning, following the subject simulation; (4) final localization of the subject in the medical therapy room for BNCT; and (5) final post facto recalculation of the doses delivered based on firm knowledge of the blood boron-10 concentration profiles and the neutron flux histories from precise online monitoring. The computer-assisted treatment planning is done using a specially written BNCT treatment planning code called MacNCTPLAN. The code uses the Los Alamos National Laboratory's Monte Carlo n-particle radiation transport code MCNPv.4b as the dose calculation engine and advanced anatomical model simulation based on an automatic evaluation of CT scan data. Results are displayed as isodose contours and dose-volume histograms, the latter correlated precisely with corresponding anatomical CT or MRI image planes. Examples of typical treatment planning scenarios will be presented. (author)

  14. Reporting on What Jane Saw 2.0: Female Celebrity and Sensationalism in Boydell’s Shakespeare Gallery

    Directory of Open Access Journals (Sweden)

    Janine Barchas

    2015-03-01

    Full Text Available This essay reports on ongoing efforts to build an accurate digital model of John Boydell’s popular Shakespeare Gallery precisely as it looked in August 1796—when a 20-year-old Jane Austen visited London’s sites, staying within a ten-minute walk from the gallery. The essay argues for the substantial difference between studying Boydell’s pictures in a paper volume (whether as lists, illustrations in books, or engraved folio plates and viewing them as an exhibition of paintings on walls, albeit virtual ones. For example, the digital reconstruction illuminated commissions from several female participants in Boydell’s male-dominated gallery, especially Angelica Kauffman (1741-1807 and Anne Seymour Damer (1749-1828. In addition, the essay also recounts how the celebrity of model Emma Hart/Hamilton (1765-1815 safeguarded one Boydell painting from oblivion while The Shakespeare Gallery proved the site of a strange form of self-promotion practiced by actress Mary Wells (1762-1829. Our digital visualization of an historic exhibition in 1796 brought the controversial celebrity of a few women artists into focus. In sum, this essay shows DH methodology in action while sampling what might be gleaned when digital tools serve historical scholarship in the humanities.

  15. Contracorrentes em tempos de tempestades: o pensamento de Jane Addams e de Mary Richmond no Serviço Social

    Directory of Open Access Journals (Sweden)

    Maria Irene de Carvalho

    2012-09-01

    Full Text Available

    O pensamento de Jane Addams e de Mary Richmond está associado à construção do conhecimento em Serviço Social na modernidade. No final do século XIX e início do século XX, estas figuras incontornáveis do Serviço Social integraram a profissão na divisão sociotécnica do trabalho e na agenda dos países envolvidos com a questão social. Este texto tem como objetivo examinar a relação implícita das autoras com o Serviço Social, enfatizando a emergência e construção do mesmo como uma ação “quase profissional”. Adotamos uma metodologia qualitativa baseada na análise bibliográfica, a qual permitiu situar o contexto da modernidade e comparar o percurso pessoal de Richmond e Addams tendo em conta: a trajetória pessoal e profissional; as perspetivas teóricas do Serviço Social na abordagem dos problemas sociais; as organizações e as práticas e os principais contributos e inovações num
    contexto de reforma social.

  16. ABORTION AND VIOLENCE IN JANE MARTIN’S KEELY AND DU: PRO-CHOICE, PRO-LIFE, OR MERELY PROVOCATIVE?

    Directory of Open Access Journals (Sweden)

    Eta Farmacelia Nurulhady

    2017-04-01

    Full Text Available Abortion and violence are global issues, yet different culture might respond to the issues somewhat differently. This study aims to reveal the abortion and violence issues in Jane Martin’s Keely and Du in terms of pro-choice and pro life movements and see how Indonesian students reading the play respond to the issues. In the United States of America, the discussion of abortion issue can be grouped into two major categories: the pro-life and pro-choice. In Indonesia, the majority of people would be against abortion when it is not for medical reasons. The students reading Keely and Du find the play challenging their beliefs as religious people still keeping hold of eastern values. Having discussed the nature of pro-life and pro-choice movements, it is difficult for them to decide whether they are proponent of either one. Keely and Du is successfully provocative in offering insight on how abortion and violence issues cannot be judged in a black and white manner.

  17. The importance of biological oxidation of iron in the aerobic cells of the Wheal Jane pilot passive treatment system.

    Science.gov (United States)

    Hall, G; Swash, P; Kotilainen, S

    2005-02-01

    The passive treatment system designed to treat the mine water discharge of the abandoned Wheal Jane tin mine in Cornwall consisted of a sequence of artificial wetland cells, an anaerobic cell and a final series of rock filters. Three systems were operated which differed only in the pre-treatment of the mine water before discharge to the aerobic wetland cells. The aerobic cells were designed to promote aerobic oxidation and precipitation of iron which could exceed a concentration of 100 mg/l in the raw mine water discharge. The largest investment of land area was to the artificial wetland cells and it was important to understand the processes of oxidation and precipitation of iron so that the performance of this aspect the pilot passive treatment plant (PPTP) could be managed as efficiently as possible. The generally low pH of the influent mine water and inevitable trend of decreasing pH due to hydrolysis of Fe(III) meant that distinguishing between biotic and abiotic mechanisms was fundamental for further design planning of passive treatment systems. This paper describes these observations.

  18. Water quality and ecology of the River Lee: mass balance and a review of temporal and spatial data

    Directory of Open Access Journals (Sweden)

    D. L. Snook

    2004-01-01

    Full Text Available A regional overview of the water quality and ecology of the River Lee catchment is presented. Specifically, data describing the chemical, microbiological and macrobiological water quality and fisheries communities have been analysed, based on a division into river, sewage treatment works, fish-farm, lake and industrial samples. Nutrient enrichment and the highest concentrations of metals and micro-organics were found in the urbanised, lower reaches of the Lee and in the Lee Navigation. Average annual concentrations of metals were generally within environmental quality standards although, on many occasions, concentrations of cadmium, copper, lead, mercury and zinc were in excess of the standards. Various organic substances (used as herbicides, fungicides, insecticides, chlorination by-products and industrial solvents were widely detected in the Lee system. Concentrations of ten micro-organic substances were observed in excess of their environmental quality standards, though not in terms of annual averages. Sewage treatment works were the principal point source input of nutrients, metals and micro-organic determinands to the catchment. Diffuse nitrogen sources contributed approximately 60% and 27% of the in-stream load in the upper and lower Lee respectively, whereas approximately 60% and 20% of the in-stream phosphorus load was derived from diffuse sources in the upper and lower Lee. For metals, the most significant source was the urban runoff from North London. In reaches less affected by effluent discharges, diffuse runoff from urban and agricultural areas dominated trends. High microbiological content, observed in the River Lee particularly in urbanised reaches, was far in excess of the EC Bathing Water Directive standards. Water quality issues and degraded habitat in the lower reaches of the Lee has led to impoverished aquatic fauna but, within the mid-catchment reaches and upper agricultural tributaries, less nutrient enrichment and channel

  19. Parametric study of the fractional-order Chen-Lee system

    Energy Technology Data Exchange (ETDEWEB)

    Tam, L.M. [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Tomas Pereira S.J., Taipa, Macau (China)], E-mail: fstlmt@umac.mo; Tou, W.M.S. [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Tomas Pereira S.J., Taipa, Macau (China)

    2008-08-15

    The dynamics of fractional-order systems have attracted a great deal of attention in recent years. In this paper, the effects of parameter changes on the dynamics of the fractional-order Chen-Lee system were studied numerically. The parameter ranges used were relatively broad. The order used for the system was fixed at 2.7 (q{sub 1} = q{sub 2} = q{sub 3} = 0.9). The system displays rich dynamic behaviors, such as a fixed point, periodic motion (including period-3 motion), chaotic motion, and transient chaos. The chaotic motion identified was validated by the confirmation of a positive Lyapunov exponent. Period-doubling routes to chaos in the fractional-order Chen-Lee system were also found.

  20. Lee Wen: Lucid Dreams In the Reverie of the Real

    OpenAIRE

    Mokhtari, Sylvie

    2012-01-01

    Cette monographie rétrospective réunit la somme des travaux, associant depuis vingt ans performances et installations, de l’artiste singapourien Lee Wen (né en 1957). Ambigu et très expressive, son activité est relatée de manière biographique sous la plume de Khairuddin Hori (« If you can’t think because you can’t chew, try a banana », pp.9-19). Textes de et sur Lee Wen, témoignages, documents et travaux viennent ensuite généreusement nourrir la publication. Des Anthropométries d’Yves Klein, ...

  1. The Brain Dead Patient Is Still Sentient: A Further Reply to Patrick Lee and Germain Grisez.

    Science.gov (United States)

    Austriaco, Nicanor Pier Giorgio

    2016-06-01

    Patrick Lee and Germain Grisez have argued that the total brain dead patient is still dead because the integrated entity that remains is not even an animal, not only because he is not sentient but also, and more importantly, because he has lost the radical capacity for sentience. In this essay, written from within and as a contribution to the Catholic philosophical tradition, I respond to Lee and Grisez's argument by proposing that the brain dead patient is still sentient because an animal with an intact but severed spinal cord can still perceive and respond to external stimuli. The brain dead patient is an unconscious sentient organism. © The Author 2016. Published by Oxford University Press, on behalf of the Journal of Medicine and Philosophy Inc. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  2. Bacterial-Chromatin Structural Proteins Regulate the Bimodal Expression of the Locus of Enterocyte Effacement (LEE Pathogenicity Island in Enteropathogenic Escherichia coli

    Directory of Open Access Journals (Sweden)

    Hervé Leh

    2017-08-01

    Full Text Available In enteropathogenic Escherichia coli (EPEC, the locus of enterocyte effacement (LEE encodes a type 3 secretion system (T3SS essential for pathogenesis. This pathogenicity island comprises five major operons (LEE1 to LEE5, with the LEE5 operon encoding T3SS effectors involved in the intimate adherence of bacteria to enterocytes. The first operon, LEE1, encodes Ler (LEE-encoded regulator, an H-NS (nucleoid structuring protein paralog that alleviates the LEE H-NS silencing. We observed that the LEE5 and LEE1 promoters present a bimodal expression pattern, depending on environmental stimuli. One key regulator of bimodal LEE1 and LEE5 expression is ler expression, which fluctuates in response to different growth conditions. Under conditions in vitro considered to be equivalent to nonoptimal conditions for virulence, the opposing regulatory effects of H-NS and Ler can lead to the emergence of two bacterial subpopulations. H-NS and Ler share nucleation binding sites in the LEE5 promoter region, but H-NS binding results in local DNA structural modifications distinct from those generated through Ler binding, at least in vitro. Thus, we show how two nucleoid-binding proteins can contribute to the epigenetic regulation of bacterial virulence and lead to opposing bacterial fates. This finding implicates for the first time bacterial-chromatin structural proteins in the bimodal regulation of gene expression.

  3. Economics case study: Harvard Business School pedagogy techniques: From teaching entrepreneurship to influencing business policy through research

    OpenAIRE

    MAMOON, Dawood

    2017-01-01

    Abstract. The case study explains the need for social entrepreneurship while remaining in the premise of mainstream economics. A detailed discussion is carried out on the vulnerabilities of economic policy making that has led to some of the new initiatives at Harvard Business School to promote such pedagogy practices at Business Schools that may eventually influence national and international policy making to the benefit of the society and not only the economies of developed and developing co...

  4. Lead candidates for high-performance organic photovoltaics from high-throughput quantum chemistry – the Harvard Clean Energy Project

    OpenAIRE

    Hachmann, Johannes; Olivares-Amaya, Roberto; Jinich, Adrian; Appleton, Anthony L.; Blood-Forsythe, Martin; Seress, Laszlo Ryan; Román-Salgado, Carolina; Trepte, Kai; Atahan-Evrenk, Sule; Er, Suleyman; Shrestha, Supriya; Mondal, Rajib; Sokolov, Anatoliy; Bao, Zhenan; Aspuru-Guzik, Alan

    2014-01-01

    The virtual high-throughput screening framework of the Harvard Clean Energy Project allows for the computational assessment of candidate structures for organic electronic materials – in particular photovoltaics – at an unprecedented scale. We report the most promising compounds that have emerged after studying 2.3 million molecular motifs by means of 150 million density functional theory calculations. Our top candidates are analyzed with respect to their structural makeup in order to identify...

  5. Cardiorespiratory endurance evaluation using heart rate analysis during ski simulator exercise and the Harvard step test in elementary school students

    OpenAIRE

    Lee, Hyo Taek; Roh, Hyo Lyun; Kim, Yoon Sang

    2016-01-01

    [Purpose] Efficient management using exercise programs with various benefits should be provided by educational institutions for children in their growth phase. We analyzed the heart rates of children during ski simulator exercise and the Harvard step test to evaluate the cardiopulmonary endurance by calculating their post-exercise recovery rate. [Subjects and Methods] The subjects (n = 77) were categorized into a normal weight and an overweight/obesity group by body mass index. They performed...

  6. Grape marc, wine lees and deposit of the must: How to manage oenological by-products?

    OpenAIRE

    Lempereur Valérie; Penavayre Sophie

    2014-01-01

    Winemaking produces solid (grape marc) and liquid (wine lees and deposit of the must) wastes named “oenological by-products”, which, according to European regulations, must be eliminated following the environmental regulatory requirement [1]. In France, these European regulations forced wine growers, until the 2013/2014 campaign, to deliver all by-products to wine distilleries. This French obligation is known as the “prestation vinique” [2, 3]. Following the Common Market Organisation wine re...

  7. LEE: Light‐Weight Energy‐Efficient encryption algorithm for sensor networks

    OpenAIRE

    Komninos, N.; Soroush, H.; Salajegheh, M.

    2007-01-01

    Data confidentiality in wireless sensor networks is mainly achieved by RC5 and Skipjack encryption algorithms. However, both algorithms have their weaknesses, for example RC5 supports variable-bit rotations, which are computationally expensive operations and Skipjack uses a key length of 80-bits, which is subject to brute force attack. In this paper we introduce a light-weight energy- fficient encryption-algorithm (LEE) for tiny embedded devices, such as sensor network nodes. We present exper...

  8. Nobelist TD LEE Scientist Cooperation Network and Scientist Innovation Ability Model

    OpenAIRE

    Fang, Jin-Qing; Liu, Qiang

    2013-01-01

    Nobelist TD Lee scientist cooperation network (TDLSCN) and their innovation ability are studied. It is found that the TDLSCN not only has the common topological properties both of scale-free and small-world for a general scientist cooperation networks, but also appears the creation multiple-peak phenomenon for number of published paper with year evolution, which become Nobelist TD Lee’s significant mark distinguished from other scientists. This new phenomenon has not been revealed in the scie...

  9. Becoming an International Scientist in South Korea: Ho Wang Lee's Research Activity about Epidemic Hemorrhagic Fever.

    Science.gov (United States)

    Shin, Miyoung

    2017-04-01

    In the 1960-70s, South Korea was still in the position of a science latecomer. Although the scientific research environment in South Korea at that time was insufficient, there was a scientist who achieved outcomes that could be recognized internationally while acting in South Korea. He was Ho Wang Lee(1928~ ) who found Hantann Virus that causes epidemic hemorrhagic fever for the first time in the world. It became a clue to identify causative viruses of hemorrhagic diseases that were scattered here and there throughout the world. In addition, these outcomes put Ho Wang Lee on the global center of research into epidemic hemorrhagic fever. This paper examines how a Korean scientist who was in the periphery of virology could go into the central area of virology. Also this article shows the process through which the virus found by Ho Wang Lee was registered with the international academia and he proceeded with follow-up research based on this progress to reach the level at which he generalized epidemic hemorrhagic fever related studies throughout the world. While he was conducting the studies, experimental methods that he had never experienced encountered him as new difficulties. He tried to solve the new difficulties faced in his changed status through devices of cooperation and connection. Ho Wang Lee's growth as a researcher can be seen as well as a view of a researcher that grew from a regional level to an international level and could advance from the area of non-mainstream into the mainstream. This analytic tool is meaningful in that it can be another method of examining the growth process of scientists in South Korea or developing countries.

  10. Cardiorespiratory endurance evaluation using heart rate analysis during ski simulator exercise and the Harvard step test in elementary school students.

    Science.gov (United States)

    Lee, Hyo Taek; Roh, Hyo Lyun; Kim, Yoon Sang

    2016-01-01

    [Purpose] Efficient management using exercise programs with various benefits should be provided by educational institutions for children in their growth phase. We analyzed the heart rates of children during ski simulator exercise and the Harvard step test to evaluate the cardiopulmonary endurance by calculating their post-exercise recovery rate. [Subjects and Methods] The subjects (n = 77) were categorized into a normal weight and an overweight/obesity group by body mass index. They performed each exercise for 3 minutes. The cardiorespiratory endurance was calculated using the Physical Efficiency Index formula. [Results] The ski simulator and Harvard step test showed that there was a significant difference in the heart rates of the 2 body mass index-based groups at each minute. The normal weight and the ski-simulator group had higher Physical Efficiency Index levels. [Conclusion] This study showed that a simulator exercise can produce a cumulative load even when performed at low intensity, and can be effectively utilized as exercise equipment since it resulted in higher Physical Efficiency Index levels than the Harvard step test. If schools can increase sport durability by stimulating students' interests, the ski simulator exercise can be used in programs designed to improve and strengthen students' physical fitness.

  11. Outlining the influence of non-conventional yeasts in wine ageing over lees.

    Science.gov (United States)

    Belda, Ignacio; Navascués, Eva; Marquina, Domingo; Santos, Antonio; Calderón, Fernando; Benito, Santiago

    2016-07-01

    During the last decade, the use of innovative yeast cultures of both Saccharomyces cerevisiae and non-Saccharomyces yeasts as alternative tools to manage the winemaking process have turned the oenology industry. Although the contribution of different yeast species to wine quality during fermentation is increasingly understood, information about their role in wine ageing over lees is really scarce. This work aims to analyse the incidence of three non-Saccharomyces yeast species of oenological interest (Torulaspora delbrueckii, Lachancea thermotolerans and Metschnikowia pulcherrima) and of a commercial mannoprotein-overproducer S. cerevisiae strain compared with a conventional industrial yeast strain during wine ageing over lees. To evaluate their incidence in mouthfeel properties of wine after 4 months of ageing, the mannoprotein content of wines was evaluated, together with other wine analytic parameters, such as colour and aroma, biogenic amines and amino acids profile. Some differences among the studied parameters were observed during the study, especially regarding the mannoprotein concentration of wines. Our results suggest that the use of T. delbrueckii lees in wine ageing is a useful tool for the improvement of overall wine quality by notably increasing mannoproteins, reaching values higher than obtained using a S. cerevisiae overproducer strain. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  12. An unusual feature associated with LEE1 P1 promoters in enteropathogenic Escherichia coli (EPEC).

    Science.gov (United States)

    Jeong, Jae-Ho; Kim, Hyun-Ju; Kim, Kun-Hee; Shin, Minsang; Hong, Yeongjin; Rhee, Joon Haeng; Schneider, Thomas D; Choy, Hyon E

    2012-02-01

    Transcription start points in bacteria are influenced by the nature of the RNA polymerase·promoter interaction. For Escherichia coli RNA polymerase holoenzyme containing σ70, it is presumed that specific sequence in one or more of the -10, extended -10 and -35 elements of the promoter guides the RNAP to select the cognate start point. Here, we investigated the promoter driving expression of the LEE1 operon in enteropathogenic E. coli and found two promoters separated by 10 bp, LEE1 P1A (+1) and LEE1 P1B (+10) using various in vitro biochemical tools. A unique feature of P1B was the presence of multiple transcription starts from five neighbouring As at the initial transcribed region. The multiple products did not arise from stuttering synthesis. Analytical software based on information theory was employed to determine promoter elements. The concentration of the NTP pool altered the preferred transcription start points, albeit the underlying mechanism is elusive. Under in vivo conditions, dominant P1B, but not P1A, was subject to regulation by IHF. © 2012 Blackwell Publishing Ltd.

  13. Observation of Mountain Lee Waves with MODIS NIR Column Water Vapor

    Science.gov (United States)

    Lyapustin, A.; Alexander, M. J.; Ott, L.; Molod, A.; Holben, B.; Susskind, J.; Wang, Y.

    2014-01-01

    Mountain lee waves have been previously observed in data from the Moderate Resolution Imaging Spectroradiometer (MODIS) "water vapor" 6.7 micrometers channel which has a typical peak sensitivity at 550 hPa in the free troposphere. This paper reports the first observation of mountain waves generated by the Appalachian Mountains in the MODIS total column water vapor (CWV) product derived from near-infrared (NIR) (0.94 micrometers) measurements, which indicate perturbations very close to the surface. The CWV waves are usually observed during spring and late fall or some summer days with low to moderate CWV (below is approx. 2 cm). The observed lee waves display wavelengths from3-4 to 15kmwith an amplitude of variation often comparable to is approx. 50-70% of the total CWV. Since the bulk of atmospheric water vapor is confined to the boundary layer, this indicates that the impact of thesewaves extends deep into the boundary layer, and these may be the lowest level signatures of mountain lee waves presently detected by remote sensing over the land.

  14. Forecasting the mortality rates using Lee-Carter model and Heligman-Pollard model

    Science.gov (United States)

    Ibrahim, R. I.; Ngataman, N.; Abrisam, W. N. A. Wan Mohd

    2017-09-01

    Improvement in life expectancies has driven further declines in mortality. The sustained reduction in mortality rates and its systematic underestimation has been attracting the significant interest of researchers in recent years because of its potential impact on population size and structure, social security systems, and (from an actuarial perspective) the life insurance and pensions industry worldwide. Among all forecasting methods, the Lee-Carter model has been widely accepted by the actuarial community and Heligman-Pollard model has been widely used by researchers in modelling and forecasting future mortality. Therefore, this paper only focuses on Lee-Carter model and Heligman-Pollard model. The main objective of this paper is to investigate how accurately these two models will perform using Malaysian data. Since these models involves nonlinear equations that are explicitly difficult to solve, the Matrix Laboratory Version 8.0 (MATLAB 8.0) software will be used to estimate the parameters of the models. Autoregressive Integrated Moving Average (ARIMA) procedure is applied to acquire the forecasted parameters for both models as the forecasted mortality rates are obtained by using all the values of forecasted parameters. To investigate the accuracy of the estimation, the forecasted results will be compared against actual data of mortality rates. The results indicate that both models provide better results for male population. However, for the elderly female population, Heligman-Pollard model seems to underestimate to the mortality rates while Lee-Carter model seems to overestimate to the mortality rates.

  15. Caught Up In Between Doublets: Neo-Victorian (TransPositions of Victorian Femininities and Masculinities in Jane Eyre and Rebecca Entre les doublets : (transpositions néo-victoriennes des figures victoriennes de la féminité et de la masculinité dans Jane Eyre et Rebecca

    Directory of Open Access Journals (Sweden)

    Marta Miquel-Baldellou

    2009-07-01

    Full Text Available En se départissant de la dichotomie victorienne manichéenne de l’ange du foyer et de la femme déchue pour éclairer les personnages de Jane et Bertha dans leur ouvrage pionnier The Madwoman in the Attic, Sandra Gilbert et Susan Gubar étudièrent la première épouse de Rochester, folle, comme le double subversif de Jane, faisant ainsi de Jane et de Bertha les facettes d’un seul et même personnage. Malgré le rejet moderniste des excès supposés de l’ère victorienne, Rebecca de Daphne du Maurier exploite une intrigue triangulaire similaire qui réinterprète et recrée Rochester, Bertha et Jane à travers Maxime de Winter, Rebecca et Mrs de Winter. Les conceptions victoriennes des féminités doubles, des doublets féminins pour ainsi dire, sont perpétuées et réactualisées à travers les textualités néo-victoriennes. Néanmoins, peut-on vraiment voir dans Bertha un personnage que Rochester tente d’assagir par l’entremise de la figure de l’ange du foyer, plutôt qu’un archétype de la femme déchue ? Jane n’est-elle pas destinée à découvrir le secret de Rochester avant de l’épouser ? Mrs de Winter a-t-elle à ce point le sens du sacré qu’elle ne cherche pas à entrer en concurrence avec Rebecca ? Rebecca est-elle à ce point élégante et infaillible qu’elle parvient à ne pas s’attirer le mépris de Maxime ? Cet article se propose d’examiner comment les héroïnes sont investies en termes de rôles sexuels dans l’écriture néo-victorienne – comment les rôles de l’ange du foyer et de la femme déchue dans Jane Eyre sont perpétués et subvertis à travers Rebecca en tant que texte moderne – et d’identifier et d’étudier les perceptions masculines victoriennes et néo-victoriennes.

  16. The affect of a clearcut environment on woody debris respiration rate dynamics, Harvard Forest, Massachusetts

    Science.gov (United States)

    Vanderhoof, M. K.; Williams, C. L.

    2011-12-01

    At an ecosystem scale, the distribution of carbon is largely a function of stand development and disturbance processes. Clearcut logging remains a common practice both in the United States and globally and typically results in elevated storage of carbon in onsite woody debris and detritus. The residence time and decomposition rate of this woody debris and detritus will affect the rate of CO2 efflux to the atmosphere and thus affect the long term consequences of such disturbances on carbon flux and storage. The removal of a forest canopy also affects a site's microclimate including the albedo, air temperature, air humidity, as well as soil temperature and moisture, many of the same factors that affect the rate of woody debris decomposition. Thus it could be expected that differences in woody debris characteristics (e.g. size, abundance, state of decay), as well as differences in microclimate, between mature and recently clearcut forest sites, would result in differences in piece and site-level woody debris decomposition rates. Although woody debris stocks post-harvest have been well characterized, few studies have explored post-disturbance woody debris respiration rates, which directly measures carbon emissions from woody debris, distinguishing decomposition from mass loss due to fragmentation or leaching. This study addressed the question: does a clearcut environment in a temperate forest affect the rate of decomposition of coarse woody debris? The rate of respiration of downed spruce logs were repeatedly measured in-situ using an LI-6250 gas analyzer in Harvard Forest, Petersham, Massachusetts. Treatments included clear-cut, shaded clear-cut, mature spruce stand, and transfer (from clearcut to spruce stand). Gas analyzer measurements were accompanied by measurements of log temperature and percent water, soil temperature, moisture and pH, as well as light levels, air temperature and humidity to determine dominant drivers of respiration rates.

  17. Building laboratory capacity to support HIV care in Nigeria: Harvard/APIN PEPFAR, 2004–2012

    Directory of Open Access Journals (Sweden)

    Donald J. Hamel

    2015-05-01

    Full Text Available Introduction: From 2004–2012, the Harvard/AIDS Prevention Initiative in Nigeria, funded through the US President’s Emergency Plan for AIDS Relief programme, scaled up HIV care and treatment services in Nigeria. We describe the methodologies and collaborative processes developed to improve laboratory capacity significantly in a resource-limited setting. These methods were implemented at 35 clinic and laboratory locations. Methods: Systems were established and modified to optimise numerous laboratory processes. These included strategies for clinic selection and management, equipment and reagent procurement, supply chains, laboratory renovations, equipment maintenance, electronic data management, quality development programmes and trainings. Results: Over the eight-year programme, laboratories supported 160 000 patients receiving HIV care in Nigeria, delivering over 2.5 million test results, including regular viral load quantitation. External quality assurance systems were established for CD4+ cell count enumeration, blood chemistries and viral load monitoring. Laboratory equipment platforms were improved and standardised and use of point-of-care analysers was expanded. Laboratory training workshops supported laboratories toward increasing staff skills and improving overall quality. Participation in a World Health Organisation-led African laboratory quality improvement system resulted in significant gains in quality measures at five laboratories. Conclusions: Targeted implementation of laboratory development processes, during simultaneous scale-up of HIV treatment programmes in a resource-limited setting, can elicit meaningful gains in laboratory quality and capacity. Systems to improve the physical laboratory environment, develop laboratory staff, create improvements to reduce costs and increase quality are available for future health and laboratory strengthening programmes. We hope that the strategies employed may inform

  18. The milestones in patient safety -The Harvard Medical Practice Study I , Study II and Study III

    Directory of Open Access Journals (Sweden)

    Giuseppe La Torre

    2005-12-01

    Full Text Available

    Over the past decade there has been a steady increase in the number of malpractice claims brought against healthcare providers [1,2] and in the monetary damages awarded to plaintiffs [1,3]. This increase has precipitated numerous state programs designed to moderate the number of claims and encourage providers to develop quality of care initiatives [4,5].

    It is important to develop more reliable estimates of the incidence of adverse events and negligence in hospitalized patients.An adverse event is defined as an injury caused by medical management (rather than the underlying disease that prolongs the hospitalization and results in disability at the time of discharge, or both. Negligence is defined as care that has fallen below the standard expected of physicians in their community.

    The Harvard Medical Practice Study (HMPS was first published in 1991 and was based on 1984 case records of more than 30,000 randomly selected records from 51 randomly selected acute care, nonpsychiatric hospitals.The study attempts to measure the extent of medical malpractice in hospitals in the state of New York, and compare the resulting patterns with the negligence claims actually filed [6-8]. The HMPS reviews randomly selected records with disability injuries caused by medical treatment.To establish that an adverse event or negligence has occurred, it uses as a criterion an average confidence score of four or more (on a six point scale. Data identified are age, sex, and primary discharge diagnosis. The significance of the differences in rates of adverse events and negligence according to sex and age were tested.

  19. Assessment of orientation practices for ethics consultation at Harvard Medical School-affiliated hospitals.

    Science.gov (United States)

    Zaidi, Danish; Kesselheim, Jennifer C

    2018-02-01

    Few studies have been conducted to assess the quality of orientation practices for ethics advisory committees that conduct ethics consultation. This survey study focused on several Harvard teaching hospitals, exploring orientation quality and committee members' self-evaluation in the American Society of Bioethics and Humanities (ASBH) ethics consultation competencies. We conducted a survey study that involved 116 members and 16 chairs of ethics advisory committees, respectively (52% and 62.5% response rates). Predictor variables included professional demographics, duration on committees and level of training. Outcome variables included familiarity with and preparedness in the ASBH competencies and satisfaction with orientations. We hypothesised that responses would be associated with both the aforementioned predictors and whether or not participants had encountered the ASBH competencies in training. A majority of respondents found their orientation curricula to be helpful (62%), although a significant portion of respondents did not receive any orientation (24%) or were unsatisfied with their orientation (14%). Familiarity with ASBH competencies was a statistically significant predictor of respondents' self-evaluation in particular categories (54% had heard of the competencies). Standard educational materials were reported as offered during orientation, such as readings (50%) and case studies (41%); different medium resources were less evidenced such as videos on ethics consultation (19%). Institutions should re-evaluate orientation practices for ethics committee members that perform ethics consultation. Integrating ASBH competencies and useful methods into a resourceful pedagogy will help improve both member satisfaction with orientation and preparation in consultation. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  20. "He sees the development of children's concepts upon a background of sociology": Jean Piaget's honorary degree at Harvard University in 1936.

    Science.gov (United States)

    Hsueh, Yeh

    2004-02-01

    In the recent memory, Jean Piaget has been known as a cognitive developmental psychologist. But in 1936 when Harvard gave him his first honorary degree, he was recognized mainly as a sociologist. Why did Harvard honor him in 1936? Who knew his work well enough to nominate him? This article will address these questions by exploring archival documents from different sources. Evidence draws our attention to a broad social and intellectual endeavor in philanthropy, other social sciences, and especially industrial research that brought Piaget across the water. This article also attempts to interpret the circumstances of the nomination process inside and outside of Harvard University by using a theory of institutional design. It suggests that embodied in Harvard's honor of Piaget in 1936 was an idealistic act in social designing for a future society.

  1. Lee Miller à travers la Roumanie, l’appareil photo à la main (1946

    Directory of Open Access Journals (Sweden)

    Adrian-Silvan Ionescu

    2012-01-01

    Full Text Available A former model and fashion photographer turned war photographer, Lee Miller visited Romania twice, in 1938 and 1946 respectively. After her second visit she published her impressions and pictures, under the title of Roumania, in Vogue magazine. Besides the published material there are her manuscripts from The Lee Miller Achives at Farley Farm House, East Sussex, England, on which this paper is based. She crossed the border coming from Hungary in early February 1946. Heading for Sibiu her car, a Chevrolet Sedan, slipping on the ice-covered road, stopped on a snowbank far off in the ditch. While looking for help in the nearby village she and her companions left the car unguarded to discover it plundered of everything, wheels included.On a Sunday afternoon she had the privilege of being received by King Mihai I and Queen Mother Elena with whom she talked exstensively. She also took magnificent pictures with the Royal Family in the imposing Peleş Castle. At Sinaia, „the summer capital of Roumania” she had also the opportunity to portray Dinu Brătianu and Iuliu Maniu, the two elderly statesmen. Maniu was surrounded by friends and party members, among whom was young Corneliu Coposu, his private secretary.Moving to Bucharest, she met old friends such as Harri Brauner and his wife, Lena Constante, with whom she wandered through the country eight years ago. Lena and Elena Pătrășcanu, wife of Lucrețiu Pătrășcanu, Minister of Justice, have started a successful marionette theatre where Lee took nice pictures. Other were taken on the streets, with peasants, street vendors and their customers. Harri took her to a bistro where they met Maria Lătărețu, the celebrating folk singer whom Brauner recorded many times. They enjoyed her songs. Suffering from fibrositis, Lee Miller undertook a peculiar treatment in a gypsy village where the inhabitants were dancing bears trainers. She was massaged by a bear weighing about 300 pounds while Brauner took

  2. 78 FR 77508 - Duke Energy Carolinas, LLC; William States Lee III Nuclear Station, Units 1 and 2; Combined...

    Science.gov (United States)

    2013-12-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Duke Energy Carolinas, LLC; William States Lee III Nuclear Station, Units 1 and 2; Combined Licenses Application Review AGENCY: Nuclear Regulatory Commission. ACTION: Final environmental impact...

  3. H-NST induces LEE expression and the formation of attaching and effacing lesions in enterohemorrhagic Escherichia coli.

    Directory of Open Access Journals (Sweden)

    Jonathan A Levine

    Full Text Available Enteropathogenic E. coli (EPEC and enterohemorrhagic E. coli are important causes of morbidity and mortality worldwide. These enteric pathogens contain a type III secretion system (T3SS responsible for the attaching and effacing (A/E lesion phenotype. The T3SS is encoded by the locus of enterocyte effacement (LEE pathogenicity island. The H-NS-mediated repression of LEE expression is counteracted by Ler, the major activator of virulence gene expression in A/E pathogens. A regulator present in EPEC, H-NST, positively affects expression of H-NS regulon members in E. coli K-12, although the effect of H-NST on LEE expression and virulence of A/E pathogens has yet-to-be determined.We examine the effect of H-NST on LEE expression and A/E lesion formation on intestinal epithelial cells. We find that H-NST positively affects the levels of LEE-encoded proteins independently of ler and induces A/E lesion formation. We demonstrate H-NST binding to regulatory regions of LEE1 and LEE3, the first report of DNA-binding by H-NST. We characterize H-NST mutants substituted at conserved residues including Ala16 and residues Arg60 and Arg63, which are part of a potential DNA-binding domain. The single mutants A16V, A16L, R60Q and the double mutant R60Q/R63Q exhibit a decreased effect on LEE expression and A/E lesion formation. DNA mobility shift assays reveal that these residues are important for H-NST to bind regulatory LEE DNA targets. H-NST positively affects Ler binding to LEE DNA in the presence of H-NS, and thereby potentially helps Ler displace H-NS bound to DNA.H-NST induces LEE expression and A/E lesion formation likely by counteracting H-NS-mediated repression. We demonstrate that H-NST binds to DNA and identify arginine residues that are functionally important for DNA-binding. Our study suggests that H-NST provides an additional means for A/E pathogens to alleviate repression of virulence gene expression by H-NS to promote virulence capabilities.

  4. H-NST induces LEE expression and the formation of attaching and effacing lesions in enterohemorrhagic Escherichia coli.

    Science.gov (United States)

    Levine, Jonathan A; Hansen, Anne-Marie; Michalski, Jane M; Hazen, Tracy H; Rasko, David A; Kaper, James B

    2014-01-01

    Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli are important causes of morbidity and mortality worldwide. These enteric pathogens contain a type III secretion system (T3SS) responsible for the attaching and effacing (A/E) lesion phenotype. The T3SS is encoded by the locus of enterocyte effacement (LEE) pathogenicity island. The H-NS-mediated repression of LEE expression is counteracted by Ler, the major activator of virulence gene expression in A/E pathogens. A regulator present in EPEC, H-NST, positively affects expression of H-NS regulon members in E. coli K-12, although the effect of H-NST on LEE expression and virulence of A/E pathogens has yet-to-be determined. We examine the effect of H-NST on LEE expression and A/E lesion formation on intestinal epithelial cells. We find that H-NST positively affects the levels of LEE-encoded proteins independently of ler and induces A/E lesion formation. We demonstrate H-NST binding to regulatory regions of LEE1 and LEE3, the first report of DNA-binding by H-NST. We characterize H-NST mutants substituted at conserved residues including Ala16 and residues Arg60 and Arg63, which are part of a potential DNA-binding domain. The single mutants A16V, A16L, R60Q and the double mutant R60Q/R63Q exhibit a decreased effect on LEE expression and A/E lesion formation. DNA mobility shift assays reveal that these residues are important for H-NST to bind regulatory LEE DNA targets. H-NST positively affects Ler binding to LEE DNA in the presence of H-NS, and thereby potentially helps Ler displace H-NS bound to DNA. H-NST induces LEE expression and A/E lesion formation likely by counteracting H-NS-mediated repression. We demonstrate that H-NST binds to DNA and identify arginine residues that are functionally important for DNA-binding. Our study suggests that H-NST provides an additional means for A/E pathogens to alleviate repression of virulence gene expression by H-NS to promote virulence capabilities.

  5. 'Items for criticism (not in sequence)': Joseph DeLee, Pare Lorentz and The Fight for Life (1940).

    Science.gov (United States)

    Gainty, Caitjan

    2017-09-01

    In the late 1920s, the American obstetrician Joseph DeLee brought the motion-picture camera into the birth room. Following that era's trend of adapting industrial efficiency practices for medical environments, DeLee's films give spectacular and unexpected expression to the engineering concept of 'streamlining'. Accomplishing what more tangible obstetric streamlining practices had failed to, DeLee's cameras, and his post-production manipulation, shifted birth from messy and dangerous to rationalized, efficient, death-defying. This was film as an active and effective medical tool. Years later, the documentarian Pare Lorentz produced and wrote his own birth film, The Fight for Life (1940). The documentary subject of the film was DeLee himself, and the film was set in his hospitals, on the same maternity 'sets' that had once showcased film's remarkable streamlining capacity to give and keep life. Yet relatively little of DeLee was retained in the film's content, resulting in a showdown that, by way of contrast, further articulated DeLee's understanding of film's medical powers and, in so doing, hinted at a more dynamic moment in the history of medicine while speaking also to the process by which that understanding ceased to be historically legible.

  6. Potential of lees from wine, beer and cider manufacturing as a source of economic nutrients: An overview.

    Science.gov (United States)

    Pérez-Bibbins, B; Torrado-Agrasar, A; Salgado, J M; Oliveira, R Pinheiro de Souza; Domínguez, J M

    2015-06-01

    Lees are the wastes generated during the fermentation and aging processes of different industrial activities concerning alcoholic drinks such as wine, cider and beer. They must be conveniently treated to avoid uncontrolled dumping which causes environmental problems due to their high content of phenols, pesticides, heavy metals, and considerable concentrations of nitrogen, phosphate and potassium as well as high organic content. The companies involved must seek alternative environmental and economic physicochemical and biological treatments for their revalorization consisting in the recovery or transformation of the components of the lees into high value-added compounds. After describing the composition of lees and market of wine, beer and cider industries in Spain, this work aims to review the recent applications of wine, beer and cider lees reported in literature, with special attention to the use of lees as an endless sustainable source of nutrients and the production of yeast extract by autolysis or cell disruption. Lees and/or yeast extract can be used as nutritional supplements with potential exploitation in the biotechnological industry for the production of natural compounds such as xylitol, organic acids, and biosurfactants, among others. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. L’image du père et du jardin : Jane Eyre de Charlotte Brontë  et WideSargasso Sea de Jean Rhys Of Father Figures and Gardens: Charlotte Brontë’s Jane Eyre and Jean Rhys’s Wide Sargasso Sea

    Directory of Open Access Journals (Sweden)

    Anne-Marie Baranowski

    2009-10-01

    Full Text Available Though no father actually appears as a character either in Jane Eyre or in Wide Sargasso Sea, the father figure looms large in both novels, as a complex, protean and paradoxical entity, playing a crucial part in the fate of the protagonists. Jane Eyre and Antoinette Cosway are orphaned at an early age, Rochester’s father is depicted as remote and insensitive; the surrogate fathers —Antoinette’s stepfather, Jane’s uncles— mostly fail when they try to replace the missing one. Rochester himself is an ambiguous character who appears in both novels as a son, lover and husband on the one side, as a father figure on the other. In Wide Sargasso Sea he acquires through his marriage to the heiress Antoinette Cosway a legal authority which he eventually uses to destroy his wife; in Jane Eyre he first appears as the wealthier, more knowledgeable, stronger character before he discovers a female counterpart who does more than merely hold her ground.These different aspects of the father figure are closely linked to the motif of the garden which mirrors the inner development of the —mostly— female characters. It is not entirely similar to nature itself, though it is part of it; the latter means in both novels lethal dangers and elemental violence, whereas the garden is a sheltered place. In Wide Sargasso Sea, the debased garden of Coulibri simultaneously conveys a distorted, though by no means untrue reflection of the father figure and a sanctuary from the harshness of the outside world. It also means a place of peace and of simple joys for Jane Eyre, making up for the deprived life at the Lowood boarding school; but contrasting with Coulibri it does not preclude the contact with the outside world which she actually longs for. Hence the garden mirrors the crucial moments and experiences in the lives of both heroines, including love, married life and loss.

  8. Jane Austen e a recodificação paródica do gótico em Northanger Abbey

    Directory of Open Access Journals (Sweden)

    Genilda Azeredo

    2012-11-01

    The purpose of this essay is to discuss the constructions and effects of the parodic dialogue Jane Austen’s novel Northanger Abbey (1818 establishes with a tradition of Gothic literature in the eighteenth-century English context. Because it is considered as an expressive form of intertextuality, parody (both in the sense of ‘parallel song’ and ‘counter-song’ actively and creatively recodifies the tradition it parodies. As a consequence, studying such an articulation means being aware of a comparative interplay among codes, textualities, readings and literary traditions, so as to recognize the effects of parody as also articulated with a larger context of metafiction.

  9. La visión cinematográfica de Joe Wright sobre “Orgullo y Prejuicio” de Jane Austen : análisis comparativo

    OpenAIRE

    Serrano Leiva, Alicia

    2015-01-01

    Se analiza la relación entre la novela más famosa de Jane Austen, “Orgullo y Prejuicio”, y su última adaptación al cine de la mano del director Joe Wright en 2005. El objetivo es determinar el grado de fidelidad literaria y la importancia que puede tener en el éxito de la película. Se aborda el contexto político, económico, social y cultural de la novela y de su autora

  10. Generation of hyperchaos from the Chen-Lee system via sinusoidal perturbation

    Energy Technology Data Exchange (ETDEWEB)

    Tam, L.M. [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Thomas Pereira S.J., Taipa, Macau (China)], E-mail: fstlmt@umac.mo; Chen, J.H. [Department of Mechanical Engineering, Chung Hua University, Hsinchu, Taiwan (China); Chen, H.K. [Department of Mechanical Engineering, Hsiuping Institute of Technology, Taichung, Taiwan (China); Wai Meng Si Tou [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Thomas Pereira S.J., Taipa, Macau (China)

    2008-11-15

    A system with more than one positive Lyapunov exponent can be classified as a hyperchaotic system. In this study, a sinusoidal perturbation was designed for generating hyperchaos from the Chen-Lee chaotic system. The hyperchaos was identified by the existence of two positive Lyapunov exponents and bifurcation diagrams. The system is hyperchaotic in several different regions of the parameters c, {epsilon}, and {omega}. It was found that this method not only can enhance or suppress chaotic behavior, but also induces chaos in non-chaotic parameter ranges. In addition, two interesting dynamical behaviors, Hopf bifurcation and intermittency, were also found in this study.

  11. Adaptation of Sing Lee's model to the Filippov type plasma focus geometry

    International Nuclear Information System (INIS)

    Siahpoush, V; Tafreshi, M A; Sobhanian, S; Khorram, S

    2005-01-01

    A new model for plasma behaviour in Filippov type plasma focus (PF) systems has been described and used. This model is based on the so-called slug model and Sing Lee's model for Mather type PF devices. Using the model, the discharge current and its derivative as a function of time, and the pinch time and the maximum discharge current as a function of pressure, have been predicted. At the end, the predicted data are compared with the experimental data obtained through a Filippov type PF facility with a nominal maximum energy of 90 kJ

  12. Visioni vittoriane: il paesaggio fiorentino nelle opere di Janet Ross e Vernon Lee

    Directory of Open Access Journals (Sweden)

    Gabriele Corsani

    2015-11-01

    Full Text Available Fra l’ultimo scorcio dell’Ottocento e i primi decenni del Novecento Firenze e i suoi dintorni sono il soggetto privilegiato di una grande quantità di descrizioni, note di diario, racconti, opera di scrittori stranieri, in particolare inglesi, che si radicano nell’approdo elettivo di quei luoghi. Il testo presenta la traccia letteraria del paesaggio fiorentino nelle opere di Vernon Lee e Janet Ross, due tipiche rappresentanti di questa tendenza che hanno vissuto, attraverso vicende biografiche in qualche modo parallele, un’esperienza di intensa identificazione con il paesaggio fiorentino. Di Janet Ross, viene commentato Old Florence and Modern Tuscany, volume che raccoglie una serie di articoli pubblicati su alcune riviste inglesi e fornisce una efficace panoramica sull’interesse molto concreto di Janet Ross per il mondo rurale che la vede addirittura impegnata nella gestione della fattoria di Castagnolo, a Lastra a Signa. Più sfaccettato è il commento alle opere di Vernon Lee, di cui sono commentati passi da Vanitas. Polite Stories, Genius Loci, Hortus Vitae and Limbo, in virtù della maggiore ampiezza e complessità del suo mondo culturale. Ne sono cifra distintiva la associazione fra storia e realtà attraverso la dimensione del mistero, che risulta una delle chiavi di acccesso alla bellezza e alla vitalità del paesagggio e la capacità di cogliere il ritmo proprio dei luoghi e di entrare in reale sintonia con essi. 

  13. Electricity generation using white and red wine lees in air cathode microbial fuel cells

    Science.gov (United States)

    Pepe Sciarria, Tommy; Merlino, Giuseppe; Scaglia, Barbara; D'Epifanio, Alessandra; Mecheri, Barbara; Borin, Sara; Licoccia, Silvia; Adani, Fabrizio

    2015-01-01

    Microbial fuel cell (MFC) is a useful biotechnology to produce electrical energy from different organic substrates. This work reports for the first time results of the application of single chamber MFCs to generate electrical energy from diluted white wine (WWL) and red wine (RWL) lees. Power obtained was of 8.2 W m-3 (262 mW m-2; 500 Ω) and of 3.1 W m-3 (111 mW m-2; 500Ω) using white and red wine lees, respectively. Biological processes lead to a reduction of chemical oxygen (TCOD) and biological oxygen demand (BOD5) of 27% and 83% for RWL and of 90% and 95% for WWL, respectively. These results depended on the degradability of organic compounds contained, as suggest by BOD5/TCOD of WWL (0.93) vs BOD5/TCOD of RWL (0.33), and to the high presence of polyphenols in RWL that inhibited the process. Coulombic efficiency (CE) of 15 ± 0%, for WWL, was in line with those reported in the literature for other substrates, i.e. CE of 14.9 ± 11.3%. Different substrates led to different microbial consortia, particularly at the anode. Bacterial species responsible for the generation of electricity, were physically connected to the electrode, where the direct electron transfer took place.

  14. Grape marc, wine lees and deposit of the must: How to manage oenological by-products?

    Directory of Open Access Journals (Sweden)

    Lempereur Valérie

    2014-01-01

    Full Text Available Winemaking produces solid (grape marc and liquid (wine lees and deposit of the must wastes named “oenological by-products”, which, according to European regulations, must be eliminated following the environmental regulatory requirement [1]. In France, these European regulations forced wine growers, until the 2013/2014 campaign, to deliver all by-products to wine distilleries. This French obligation is known as the “prestation vinique” [2, 3]. Following the Common Market Organisation wine reform, a consultation was initiated by FranceAgriMer on the potential value of oenological by-products. The French Institute of Vine and Wine (IFV coordinated a national experimentation from 2010 to 2013 about recovery of by-products, with the support of members of the Technical Group: Association des Viticulteurs d'Alsace (AVA, Comité Interprofessionnel du Vin de Champagne (CIVC, Institut Technique des Corps Gras (ITERG, et Union Nationale des Groupements de Distillateurs d'Alcool (UNGDA. Distillation of grape marc and wine lees spreading and composting, and anaerobic digestion of grape marc were studied in order to answer the following questions: What technical feasibility? What environmental impact? What cost for winegrowers? What conformity with the regulations, including environmental regulatory obligations? [4].

  15. South Korean Government under the former CEO, President Lee Myung-bak

    Directory of Open Access Journals (Sweden)

    Eunsook Yang

    2008-10-01

    Full Text Available Tras un prometedor inicio gracias a su arrolladora victoria en diciembre del 2007 y portando un mandato para llevar a cabo profundas reformas económicas, el presidente Lee Myung-bak se ha visto obligado a recuperar la confianza de su ciudadanía tras las duras críticas a numerosos aspectos de su política: la importación de carne vacuna bajo el Tratado de Libre Comercio EEUU-Corea del Sur pendiente de aprobación, sus ambiciosos proyectos de construcción, su agenda de privatizaciones y su estilo algo autoritario. Las características de su política exterior resultan interesantes por los contrastes con su predecesor: refuerzo de la alianza con los EEUU, mejora de las relaciones con Japón, mayor dinamismo en su diplomacia energética hacia Rusia, mayor envergadura a su relación con China y una postura más firme hacia Corea del Norte. Sin embargo Lee Myung-bak ha de superar el desafío que la crisis económica mundial le presenta y así poder restaurar la situación económica de su país.

  16. Vitis vinifera L. cv Pinot noir pomace and lees as potential sources of bioactive compounds.

    Science.gov (United States)

    Reis, Gabriel M; Faccin, Henrique; Viana, Carine; Rosa, Marcelo Barcellos da; de Carvalho, Leandro M

    2016-11-01

    Food and agricultural industries generate substantial quantities of phenolic-rich by-products that could be valuable natural sources of antioxidants. The aim of this study was to identify and quantify the phenolic compounds and radical scavenging activities of two by-products (pomace and lees) from Vitis vinifera L. cv Pinot noir. We found a different distribution of phenolic classes (flavanols, flavonols, phenolic acids and stilbenes) and singular scavenging activity against free radicals (hydroxyl, superoxide and peroxyl radicals). The major class of phenolics in pomace was flavanols and in lees was flavonols, with catechin (117.9 ± 2.5 μg g(-1)) and quercetin (42.4 ± 1.2 μg g(-1)) being the most abundant individual compounds. We also found high potential on scavenging activity against superoxide radicals in pomace (80% of scavenging activity) and radical peroxyl (67% scavenging activity). These results show the possibility of using Pinot noir by-products as promising additives or as a source for the development of new products in different segments of the food and cosmetic industries.

  17. Nonsingular cosmology with a scale-invariant spectrum of cosmological perturbations from Lee-Wick theory

    International Nuclear Information System (INIS)

    Cai Yifu; Qiu Taotao; Brandenberger, Robert; Zhang Xinmin

    2009-01-01

    We study the cosmology of a Lee-Wick type scalar field theory. First, we consider homogeneous and isotropic background solutions and find that they are nonsingular, leading to cosmological bounces. Next, we analyze the spectrum of cosmological perturbations which result from this model. Unless either the potential of the Lee-Wick theory or the initial conditions are finely tuned, it is impossible to obtain background solutions which have a sufficiently long period of inflation after the bounce. More interestingly, however, we find that in the generic noninflationary bouncing cosmology, perturbations created from quantum vacuum fluctuations in the contracting phase have the correct form to lead to a scale-invariant spectrum of metric inhomogeneities in the expanding phase. Since the background is nonsingular, the evolution of the fluctuations is defined unambiguously through the bounce. We also analyze the evolution of fluctuations which emerge from thermal initial conditions in the contracting phase. The spectrum of gravitational waves stemming from quantum vacuum fluctuations in the contracting phase is also scale-invariant, and the tensor to scalar ratio is not suppressed.

  18. Jane Austen's lifelong health problems and final illness: New evidence points to a fatal Hodgkin's disease and excludes the widely accepted Addison's.

    Science.gov (United States)

    Upfal, A

    2005-06-01

    Jane Austen is typically described as having excellent health until the age of 40 and the onset of a mysterious and fatal illness, initially identified by Sir Zachary Cope in 1964 as Addison's disease. Her biographers, deceived both by Cassandra Austen's destruction of letters containing medical detail, and the cheerful high spirits of the existing letters, have seriously underestimated the extent to which illness affected Austen's life. A medical history reveals that she was particularly susceptible to infection, and suffered unusually severe infective illnesses, as well as a chronic conjunctivitis that impeded her ability to write. There is evidence that Austen was already suffering from an immune deficiency and fatal lymphoma in January 1813, when her second and most popular novel, Pride and Prejudice, was published. Four more novels would follow, written or revised in the shadow of her increasing illness and debility. Whilst it is impossible now to conclusively establish the cause of her death, the existing medical evidence tends to exclude Addison's disease, and suggests there is a high possibility that Jane Austen's fatal illness was Hodgkin's disease, a form of lymphoma.

  19. Polyphenols from Wine Lees as a Novel Functional Bioactive Compound in the Protection Against Oxidative Stress and Hyperlipidaemia

    Directory of Open Access Journals (Sweden)

    Irena Landeka Jurčević

    2017-01-01

    Full Text Available The study examines the potential of wine industry by-product, the lees, as a rich mixture of natural polyphenols, and its physiological potential to reduce postprandial metabolic and oxidative stress caused by a cholesterol-rich diet in in vivo model. Chemical analysis of wine lees showed that their total solid content was 94.2 %. Wine lees contained total phenols, total nonflavonoids and total flavonoids expressed in mg of gallic acid equivalents per 100 g of dry mass: 2316.6±37.9, 1332.5±51.1 and 984.1±28.2, respectively. The content of total anthocyanins expressed in mg of cyanidin-3-glucoside equivalents per 100 g of dry mass was 383.1±21.6. Antioxidant capacity of wine lees determined by the DPPH and FRAP methods and expressed in mM of Trolox equivalents per 100 g was 259.8±1.8 and 45.7±1.05, respectively. The experiment lasted 60 days using C57BL/6 mice divided in four groups: group 1 was fed normal diet and used as control, group 2 was fed normal diet with added wine lees, group 3 was fed high-cholesterol diet (HCD, i.e. normal diet with the addition of sunflower oil, and group 4 was fed HCD with wine lees. HCD increased serum total cholesterol (TC by 2.3-fold, triacylglycerol (TAG by 1.5-fold, low-density lipoprotein (LDL by 3.5-fold and liver malondialdehyde (MDA by 50 %, and reduced liver superoxide dismutase (SOD by 50 %, catalase (CAT by 30 % and glutathione (GSH by 17.5 % compared to control. Conversely, treatment with HCD and wine lees reduced TC and LDL up to 1.4 times more than with HCD only, with depletion of lipid peroxidation (MDA and restoration of SOD and CAT activities in liver, approximating values of the control. HDL levels were unaffected in any group. Serum transaminase activity showed no hepatotoxic properties in the treatment with lees alone. In the proposed model, wine lees as a rich polyphenol source could be a basis for functional food products without alcohol.

  20. Bacterial-Chromatin Structural Proteins Regulate the Bimodal Expression of the Locus of Enterocyte Effacement (LEE) Pathogenicity Island in EnteropathogenicEscherichia coli.

    Science.gov (United States)

    Leh, Hervé; Khodr, Ahmad; Bouger, Marie-Christine; Sclavi, Bianca; Rimsky, Sylvie; Bury-Moné, Stéphanie

    2017-08-08

    In enteropathogenic Escherichia coli (EPEC), the locus of enterocyte effacement (LEE) encodes a type 3 secretion system (T3SS) essential for pathogenesis. This pathogenicity island comprises five major operons ( LEE1 to LEE5 ), with the LEE5 operon encoding T3SS effectors involved in the intimate adherence of bacteria to enterocytes. The first operon, LEE1 , encodes Ler (LEE-encoded regulator), an H-NS (nucleoid structuring protein) paralog that alleviates the LEE H-NS silencing. We observed that the LEE5 and LEE1 promoters present a bimodal expression pattern, depending on environmental stimuli. One key regulator of bimodal LEE1 and LEE5 expression is ler expression, which fluctuates in response to different growth conditions. Under conditions in vitro considered to be equivalent to nonoptimal conditions for virulence, the opposing regulatory effects of H-NS and Ler can lead to the emergence of two bacterial subpopulations. H-NS and Ler share nucleation binding sites in the LEE5 promoter region, but H-NS binding results in local DNA structural modifications distinct from those generated through Ler binding, at least in vitro Thus, we show how two nucleoid-binding proteins can contribute to the epigenetic regulation of bacterial virulence and lead to opposing bacterial fates. This finding implicates for the first time bacterial-chromatin structural proteins in the bimodal regulation of gene expression. IMPORTANCE Gene expression stochasticity is an emerging phenomenon in microbiology. In certain contexts, gene expression stochasticity can shape bacterial epigenetic regulation. In enteropathogenic Escherichia coli (EPEC), the interplay between H-NS (a nucleoid structuring protein) and Ler (an H-NS paralog) is required for bimodal LEE5 and LEE1 expression, leading to the emergence of two bacterial subpopulations (with low and high states of expression). The two proteins share mutual nucleation binding sites in the LEE5 promoter region. In vitro , the binding of H

  1. Harvard Catalyst | The Clinical Translational Science Center IND/IDE Consult Service: Providing an IND/IDE Consult Service in a Decentralized Network of Academic Healthcare Centers

    Science.gov (United States)

    Winkler, Sabune J.; Bierer, Barbara E.; Wolf, Delia

    2014-01-01

    Abstract The Food and Drug Administration (FDA) regulations require sponsors of clinical investigations involving an investigational drug or device to submit an Investigational New Drug (IND) or Investigational Device Exemption (IDE) application. Strict adherence to applicable regulations is vital to the success of clinical research. Unlike most major pharmaceutical sponsors, investigator sponsors often do not fully appreciate their regulatory obligations nor have resources to ensure compliance. As a result they can place themselves and their institutions at risk. Nevertheless, investigator‐initiated clinical trials are vital to the further development of innovative drugs, biologics, and medical devices. The IND/IDE Subcommittee under the Regulatory Knowledge and Support Program at Harvard Catalyst, The Harvard Clinical and Translational Science Center worked in collaboration with Harvard and Harvard affiliated institutions to create and launch an IND/IDE Consult Service in a decentralized network of collaborating Academic Healthcare Centers (AHC). The IND/IDE Consult Service offers expertise, resources, and shared experiences to assist sponsor‐investigators and IRBs in meeting regulatory requirements for conducting and reviewing investigator‐initiated IND/IDE studies. The scope of the services provided by the Harvard Catalyst IND/IDE Consult Service are described, including the specifics of the service, lessons learned, and challenges faced, in a scalable model that builds inter‐institutional capacity. PMID:24455986

  2. A model for training medical student innovators: the Harvard Medical School Center for Primary Care Abundance Agents of Change program

    Directory of Open Access Journals (Sweden)

    David B. Duong

    2016-06-01

    Full Text Available Background: In 2013, the Harvard Medical School Center for Primary Care established the Abundance Agents of Change (AoC program to promote interprofessional learning and innovation, increase partnership between 15 academic and community health centers (CHCs in Boston's most under-served communities, and increase medical student interest in primary care careers. Methods: The AoC is modeled in the form of a ‘grants challenge’, offering $20,000 to interprofessional student teams to develop an innovative solution that addresses a healthcare delivery need identified by CHCs. The program's initial two years were characterized by a four-stage process which included working with CHCs and crafting a request for proposals, forming interprofessional 20 student teams comprising students from across and outside of Harvard University, training students using a systems-based innovation curriculum, and performing program evaluation. Results: Our evaluation data from cohorts 1 and 2 of the AoC program demonstrate that we succeeded in training students as innovators and members of interprofessional teams. We also learned valuable lessons regarding creating better alignment with CHC priorities, extending the program cycle from 12 to 18 months, and changing the way funding is disbursed to 25 students, which will be incorporated in later versions of the program. Conclusions: Based on our experience and evaluation data, we believe that this program is a replicable way to train students as innovators and members of interprofessional teams to address the current complex healthcare environment.

  3. RcsB determines the locus of enterocyte effacement (LEE) expression and adherence phenotype of Escherichia coli O157 : H7 spinach outbreak strain TW14359 and coordinates bicarbonate-dependent LEE activation with repression of motility.

    Science.gov (United States)

    Morgan, Jason K; Vendura, Khoury W; Stevens, Stanley M; Riordan, James T

    2013-11-01

    The 2006 US spinach outbreak of Escherichia coli O157 : H7, characterized by unusually severe disease, has been attributed to a strain (TW14359) with enhanced pathogenic potential, including elevated virulence gene expression, robust adherence and the presence of novel virulence factors. This study proposes a mechanism for the unique virulence expression and adherence phenotype of this strain, and further expands the role for regulator RcsB in control of the E. coli locus of enterocyte effacement (LEE) pathogenicity island. Proteomic analysis of TW14359 revealed a virulence proteome consistent with previous transcriptome studies that included elevated levels of the LEE regulatory protein Ler and type III secretion system (T3SS) proteins, secreted T3SS effectors and Shiga toxin 2. Basal levels of the LEE activator and Rcs phosphorelay response regulator, RcsB, were increased in strain TW14359 relative to O157 : H7 strain Sakai. Deletion of rcsB eliminated inherent differences between these strains in ler expression, and in T3SS-dependent adherence. A reciprocating regulatory pathway involving RcsB and LEE-encoded activator GrlA was identified and predicted to co-ordinate LEE activation with repression of the flhDC flagellar regulator and motility. Overexpression of grlA was shown to increase RcsB levels, but did not alter expression from promoters driving rcsB transcription. Expression of rcsDB and RcsB was determined to increase in response to physiological levels of bicarbonate, and bicarbonate-dependent stimulation of the LEE was shown to be dependent on an intact Rcs system and ler activator grvA. The results of this study significantly broaden the role for RcsB in enterohaemorrhagic E. coli virulence regulation.

  4. Jane Addams’ Social Vision

    DEFF Research Database (Denmark)

    Villadsen, Kaspar

    2018-01-01

    resonated with key tenets of social gospel theology, which imbued her texts with an overarching vision of humanity’s progressive history. It is suggested that Addams’ vision of a major transition in industrial society, one involving a BChristian renaissance^ and individuals’ transformation into Bsocialized...

  5. Katrin Pajuste / Jane Frey

    Index Scriptorium Estoniae

    Frey, Jane, 1950-

    2005-01-01

    24. septembril 2004. a. kaitses Katrin Pajuste Tartu Ülikoolis väitekirja teemal "Õhusaasteainete sadenemine ja transformeerumine okaspuumetsades: Eesti riiklike seireandmete põhjal" ("Deposition and transformation of air pollutants in coniferous forests: a study based on Estonian monitoring data")

  6. Interpretation for ''high''-Tc of the totally interconnected solution of the Ma and Lee model

    International Nuclear Information System (INIS)

    Wiecko, C.

    1988-09-01

    The already presented totally interconnected (mean-field) approximation of the Ma and Lee model, pictures very well many ingredients of the present status of comprehension of high-T c superconductors. The picture is that of a disordered grain with variable number of particles available for an attractive on-site pairing interaction, embedded in a reservoir of normal particles which fix the chemical potential. Interesting effect of absence of T c and then a sharp increase and slow decay of T c with disorder appears for weak coupling pairing as compared with the hopping probability for single particles. Interpretation is given in terms of one-particle Anderson localization theory and standard mechanisms. (author). 13 refs, 4 figs

  7. Lee-Yang-inspired functional with a density-dependent neutron-neutron scattering length

    Science.gov (United States)

    Grasso, M.; Lacroix, D.; Yang, C. J.

    2017-05-01

    Inspired by the low-density Lee-Yang expansion for the energy of a dilute Fermi gas of density ρ and momentum kF, we introduce here a Skyrme-type functional that contains only s -wave terms and provides, at the mean-field level, (i) a satisfactory equation of state for neutron matter from extremely low densities up to densities close to the equilibrium point, and (ii) a good-quality equation of state for symmetric matter at density scales around the saturation point. This is achieved by using a density-dependent neutron-neutron scattering length a (ρ ) which satisfies the low-density limit (for Fermi momenta going to zero) and has a density dependence tuned in such a way that the low-density constraint |a (ρ ) kF|≤1 is satisfied at all density scales.

  8. Vernon Lee in the Vatican: the uneasy alliance of aestheticism and archaeology.

    Science.gov (United States)

    Evangelista, Stefano

    2009-01-01

    From the 1800s onward, aesthetic critics attempted to free the study of ancient Greek art from the frameworks of institutional education and professionalized criticism. In this process, aestheticism entered an uneasy alliance with archaeology, a discipline that was likewise challenging traditional modes of classical learning practiced in public schools and the old universities. In "The Child in the Vatican" (1881), Vernon Lee -- writing under the influence of Pater and from a position of cosmopolitan female amateurism -- examines the uses of archaeological science in the study of classical art. Her analysis of the sculptures of the Niobe Group at once relies on the archaeological method and asks readers to doubt scientific approaches to art that dim the sublime power of the art object.

  9. Enigmatic eight-meter trace fossils in the Lower Pennsylvanian Lee sandstone, central Appalachian basin, Tennessee

    Science.gov (United States)

    Wnuk, C.; Maberry, J.O.

    1990-01-01

    Enigmatic tubular trace fossils up to eight meters long occur in the Lower Pennsylvanian Middlesboro Member of the Lee Formation. Two morphotypes occur: type 1 trace fossils are plain, smooth, vertical, nonbranching, parallel-walled, tubular structures, type 2 trace fossils branch, have walls with faint vertical striations, regularly or irregularly spaced nodes, and funnel-shaped terminations. Sandstone casts filling type 2 structures have helical spiral morphology, and, in rare individuals, faint meniscate fills have been observed. Both trace-fossil morphotypes have poorly cemented wall linings containing framboidal pyrite, amorphous carbon, quartz sand, and poorly preserved fecal material. The trace fossils occur in a massive, structureless, channel-form sandstone, originating at the contact between a channel lag and the overlying massive fill representing a barrier island transgressing an estuarine facies. Origin of these structures is uncertain. -from Authors

  10. The Yang-Lee edge singularity for the Ising model on two Sierpinski fractal lattices

    Energy Technology Data Exchange (ETDEWEB)

    Knezevic, Milan [Faculty of Physics, University of Belgrade, PO Box 368, 11000 Belgrade (Serbia); Knezevic, Dragica, E-mail: knez@ff.bg.ac.r, E-mail: dknezevic@kg.ac.r [Faculty of Natural Sciences and Mathematics, University of Kragujevac, PO Box 60, 34000 Kragujevac (Serbia)

    2010-10-15

    We study the distribution of zeros of the partition function of the ferromagnetic Ising model near the Yang-Lee edge on two Sierpiski-type lattices. We have shown that relevant correlation length displays a logarithmic divergence near the edge, {xi}{sub YL{approx}}|ln({partial_derivative}h)|{sup {Phi}} where {Phi} is a constant and {delta}h distance from the edge, in the case of a modified Sierpinski gasket with a nonuniform coordination number. It is demonstrated that this critical behavior can be related to the critical behavior of a simple zero-field Gaussian model of the same structure. We have shown that there is no such connection between these two models on a second lattice that has a uniform coordination number. These findings suggest that fluctuations of the lattice coordination number of a nonhomogeneous self-similar structure exert the crucial influence on the critical behavior of both models.

  11. « Et ils ne vécurent pas heureux » : la fin de Jane Eyre réécrite dans Charlotte de D.M. Thomas “And they didn’t live happily ever after”: D.M. Thomas’s Rewriting of the Ending of Jane Eyre in Charlotte

    Directory of Open Access Journals (Sweden)

    Armelle Parey

    2009-10-01

    Full Text Available D.M. Thomas’s rewriting of Jane Eyre in Charlotte (2000 takes the shape of a transformation of the ending which enables the second Mrs Rochester’s story to be continued in the West Indies, thus also acknowledging Jean Rhys’s Wide Sargasso Sea as another intertext. In order to challenge the narrative and ideological hierarchy of the source text by rewriting its ending, the pastiche defamiliarises it while some chapters set in 1999 move the limits of rewriting and take the reader into a narrative spiral.

  12. A Conversation with Lee Shulman--Signature Pedagogies for Teacher Education: Defining Our Practices and Rethinking Our Preparation

    Science.gov (United States)

    Falk, Beverly

    2006-01-01

    Lee S. Shulman is the President of The Carnegie Foundation for the Advancement of Teaching, a foundation whose mission is "to do and perform all things necessary to encourage, uphold and dignify the profession of teaching." Prior to assuming his role at Carnegie, Shulman was the Charles E. Ducommun Professor of Education at Stanford…

  13. 76 FR 79228 - Combined Licenses at William States Lee III Nuclear Station Site, Units 1 and 2; Duke Energy...

    Science.gov (United States)

    2011-12-21

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Combined Licenses at William States Lee III Nuclear Station Site, Units 1 and 2; Duke Energy Carolinas, LLC AGENCY: Nuclear Regulatory Commission. ACTION: Draft environmental impact statement; public...

  14. Q & A with Ed Tech Leaders: Interview with Curtis J. Bonk, Mimi Miyoung Lee, Thomas C. Reeves, & Thomas H. Reynolds

    Science.gov (United States)

    Viner, Mark; Gardner, Ellen; Shaughnessy, Michael F.

    2016-01-01

    Curtis J. Bonk, is Professor of Instructional Systems Technology at Indiana University and President of CourseShare. Mimi Miyoung Lee is Associate Professor in the Department of Curriculum and instruction at the University of Houston. Thomas C. Reeves is Professor Emeritus of Learning, Design, and Technology at the University of Georgia. Thomas H.…

  15. General Robert E. Lee (1807-70) and Philanthropist George Peabody (1795-1869) at White Sulphur Springs, West Virginia, July 23-Aug. 30, 1869.

    Science.gov (United States)

    Parker, Franklin; Parker, Betty J.

    This paper discusses the chance meeting at White Sulphur Springs (West Virginia) of two important public figures, Robert E. Lee and George Peabody, whose rare encounter marked a symbolic turn from Civil War bitterness toward reconciliation and the lifting power of education. The paper presents an overview of Lee's life and professional and…

  16. Long-term trends of changes in pine and oak foliar nitrogen metabolism in response to chronic nitrogen amendments at Harvard Forest, MA

    Science.gov (United States)

    Rakesh Minocha; Swathi A. Turlapati; Stephanie Long; William H. McDowell; Subhash C. Minocha

    2015-01-01

    We evaluated the long-term (1995-2008) trends in foliar and sapwood metabolism, soil solution chemistry and tree mortality rates in response to chronic nitrogen (N) additions to pine and hardwood stands at the Harvard Forest Long Term Ecological Research (LTER) site. Common stress-related metabolites like polyamines (PAs), free amino acids (AAs) and inorganic elements...

  17. Trends in Marijuana and Other Illicit Drug Use among College Students: Results from 4 Harvard School of Public Health College Alcohol Study Surveys--1993-2001

    Science.gov (United States)

    Mohler-Kuo, Meichun; Lee, Jae Eun; Wechsler, Henry

    2003-01-01

    The authors examined changes in college students' illicit drug use, patterns of polydrug use, and the relationship between students' ages of initiation of substance use and later use of marijuana and other illicit drugs between 1993 and 2001. Data from 119 US colleges and universities in the Harvard School of Public Health College Alcohol Study…

  18. Foliar free polyamine and inorganic ion content in relation to soil and soil solution chemistry in two fertilized forest stands at the Harvard Forest, Massachusetts

    Science.gov (United States)

    Rakesh Minocha; Stephanie Long; Alison H. Magill; John Aber; William H. McDowell

    2000-01-01

    Polyamines (putrescine, spermidine, and spermine) are low molecular weight, open-chained, organic polycations which are found in all organisms and have been linked with stress responses in plants. The objectives of our study were to investigate the effects of chronic N additions to pine and hardwood stands at Harvard Forest, Petersham, MA on foliar polyamine and...

  19. Responding to "Cross-Pollinating Culturally Sustaining Pedagogy and Universal Design for Learning: Toward an Inclusive Pedagogy That Accounts for Dis/Ability". A Harvard Educational Review Forum

    Science.gov (United States)

    Alim, H. Samy; Baglieri, Susan; Ladson-Billings, Gloria; Paris, Django; Rose, David H.; Valente, Joseph Michael

    2017-01-01

    In the fall of 2016, the "Harvard Educational Review" ("HER") published "Cross-Pollinating Culturally Sustaining Pedagogy and Universal Design for Learning: Toward an Inclusive Pedagogy that Accounts for Dis/Ability" by Federico R. Waitoller, assistant professor in the Department of Special Education at the University…

  20. How appropriate are two established concepts from higher education for solving complex real-world problems? A comparison of the Harvard and the ETH case study approach

    NARCIS (Netherlands)

    Steiner, G.; Laws, D.

    2006-01-01

    Purpose - The main focus of this paper is to discuss appropriate forms of higher education for building up students' competence for working on complex real-world problems. Design/methodology/approach - Within this paper the Harvard approach is accurately compared with the ETH approach by discussing

  1. Jane Eyre de Michael Berkeley et de David Malouf : La transposition opératique d’un grand classique de la littérature anglaise Jane Eyre by Michael Berkeley and David Malouf: The Operatic Rewriting of a Great Classic English Novel

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Héberlé

    2009-10-01

    Full Text Available This article discusses Michael Berkeley’s opera Jane Eyre. Premiered on June 30, 2000 by Music Theatre Wales at the Cheltenham International Festival of Music, this opera is based on the novel by Charlotte Brontë and the libretto is written by the Australian poet, novelist, playwright and librettist, David Malouf. It was risky and daring to try to adapt this famous and long novel for the stage. We will particularly focus on the similarities and differences between the novel and the opera as well as on the strategies used both by David Malouf and Michael Berkeley to adapt it. Through the analysis of the similarities we will see how Michael Berkeley set to music some of the great themes and elements of the novel: passion, a sense of entrapment, the “Gothic” atmosphere. On the other hand, the analysis of the discrepancies between the novel and the opera as they appear in both the libretto and the music will lead us to a modern apprehension of the characterization of madness as well as of the metafictional dimension of the rewriting of Jane Eyre by David Malouf and Michael Berkeley.  

  2. “There is always the other side…”: The “Other Women” of Charlotte Brontë’s Jane Eyre « Il y a toujours une autre version des faits… » : les « autres femmes » de Jane Eyre

    Directory of Open Access Journals (Sweden)

    Patricia Gott

    2009-12-01

    Full Text Available Si Jane Eyre de  Charlotte Brontë se lit essentiellement comme un  roman qui recèle un secret en son cœur, le propos de Wide Sargasso Sea  de Jean Rhys et de Rebecca de Daphné Du Maurier est en partie de  dévoiler les strates qui enveloppent ce secret pour atteindre la  vérité que contient Jane Eyre. Alors que Rhys et Du Maurier comblent  les lacunes dans l’histoire de la première épouse, apportant des  informations auxquelles Brontë se contente de faire allusion quand  elle décrit le secret de Rochester ― l’existence d’Antoinette / Bertha  Mason la folle―, les lecteurs éprouvent des sentiments variés face à  ces exemples apparemment innombrables de connivence entre les trois  romans. Juxtaposer ces trois textes pour les lire comme un ensemble permet une interprétation plus riche et plus complexe par le  biais du syncrétisme qui se met en place.

  3. Effect of Saccharomyces strains on the quality of red wines aged on lees.

    Science.gov (United States)

    Loira, I; Vejarano, R; Morata, A; Ricardo-da-Silva, J M; Laureano, O; González, M C; Suárez-Lepe, J A

    2013-08-15

    Ageing on lees involves ageing the wine in contact with yeast cells after fermentation. If combined with the addition of oak chips, it can soften the wood flavour and increase the aromatic complexity of wine. The aim of the present work is to optimise both ageing techniques through selection of an adequate Saccharomyces cerevisiae strain. The study lasted 6 months and content of polysaccharides, anthocyanins, proanthocyanidins, volatile compounds, colour parameters and sensory analysis, were periodically evaluated. Among the strains tested, G37 showed the highest release of polysaccharides (24.4±5.5 mg l(-1)). Vanillin, syringaldehyde and furfuryl alcohol increased with ageing time in 7VA2 treatment. The wine aged with CTPL14 strain presented fewer monomeric and oligomeric proanthocyanidins (12.4±0.6 and 83.4±8.3 mg l(-1), respectively), and showed the lowest astringency and bitterness sensations. Results show an improvement in the sensory profile of the red wine aged with a combination of these two techniques. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Lee-Carter state space modeling: Application to the Malaysia mortality data

    Science.gov (United States)

    Zakiyatussariroh, W. H. Wan; Said, Z. Mohammad; Norazan, M. R.

    2014-06-01

    This article presents an approach that formalizes the Lee-Carter (LC) model as a state space model. Maximum likelihood through Expectation-Maximum (EM) algorithm was used to estimate the model. The methodology is applied to Malaysia's total population mortality data. Malaysia's mortality data was modeled based on age specific death rates (ASDR) data from 1971-2009. The fitted ASDR are compared to the actual observed values. However, results from the comparison of the fitted and actual values between LC-SS model and the original LC model shows that the fitted values from the LC-SS model and original LC model are quite close. In addition, there is not much difference between the value of root mean squared error (RMSE) and Akaike information criteria (AIC) from both models. The LC-SS model estimated for this study can be extended for forecasting ASDR in Malaysia. Then, accuracy of the LC-SS compared to the original LC can be further examined by verifying the forecasting power using out-of-sample comparison.

  5. Structural modeling of age specific fertility curves in Peninsular Malaysia: An approach of Lee Carter method

    Science.gov (United States)

    Hanafiah, Hazlenah; Jemain, Abdul Aziz

    2013-11-01

    In recent years, the study of fertility has been getting a lot of attention among research abroad following fear of deterioration of fertility led by the rapid economy development. Hence, this study examines the feasibility of developing fertility forecasts based on age structure. Lee Carter model (1992) is applied in this study as it is an established and widely used model in analysing demographic aspects. A singular value decomposition approach is incorporated with an ARIMA model to estimate age specific fertility rates in Peninsular Malaysia over the period 1958-2007. Residual plots is used to measure the goodness of fit of the model. Fertility index forecast using random walk drift is then utilised to predict the future age specific fertility. Results indicate that the proposed model provides a relatively good and reasonable data fitting. In addition, there is an apparent and continuous decline in age specific fertility curves in the next 10 years, particularly among mothers' in their early 20's and 40's. The study on the fertility is vital in order to maintain a balance between the population growth and the provision of facilities related resources.

  6. Hartree-Fock treatment of Fermi polarons using the Lee-Low-Pine transformation

    Science.gov (United States)

    Kain, Ben; Ling, Hong Y.

    2017-09-01

    We consider the Fermi polaron problem at zero temperature, where a single impurity interacts with noninteracting host fermions. We approach the problem starting with a Fröhlich-like Hamiltonian where the impurity is described with canonical position and momentum operators. We apply the Lee-Low-Pine (LLP) transformation to change the fermionic Fröhlich Hamiltonian into the fermionic LLP Hamiltonian, which describes a many-body system containing host fermions only. We adapt the self-consistent Hartree-Fock (HF) approach, first proposed by Edwards, to the fermionic LLP Hamiltonian in which a pair of host fermions with momenta k and k' interact with a potential proportional to k .k' . We apply the HF theory, which has the advantage of not restricting the number of particle-hole pairs, to repulsive Fermi polarons in one dimension. When the impurity and host fermion masses are equal our variational ansatz, where HF orbitals are expanded in terms of free-particle states, produces results in excellent agreement with McGuire's exact analytical results based on the Bethe ansatz. This work raises the prospect of using the HF ansatz and its time-dependent generalization as building blocks for developing all-coupling theories for both equilibrium and nonequilibrium Fermi polarons in higher dimensions.

  7. Nobelist TD LEE Scientist Cooperation Network and Scientist Innovation Ability Model

    Directory of Open Access Journals (Sweden)

    Jin-Qing Fang

    2013-01-01

    Full Text Available Nobelist TD Lee scientist cooperation network (TDLSCN and their innovation ability are studied. It is found that the TDLSCN not only has the common topological properties both of scale-free and small-world for a general scientist cooperation networks, but also appears the creation multiple-peak phenomenon for number of published paper with year evolution, which become Nobelist TD Lee’s significant mark distinguished from other scientists. This new phenomenon has not been revealed in the scientist cooperation networks before. To demonstrate and explain this new finding, we propose a theoretical model for a nature scientist and his/her team innovation ability. The theoretical results are consistent with the empirical studies very well. This research demonstrates that the model has a certain universality and can be extended to estimate innovation ability for any nature scientist and his/her team. It is a better method for evaluating scientist innovation ability and his/her team for the academic profession and is of application potential.

  8. The spirit of St Louis: the contributions of Lee N. Robins to North American psychiatric epidemiology.

    Science.gov (United States)

    Campbell, Nancy D

    2014-08-01

    This article takes up the history of North American psychiatric epidemiology with reference to production of knowledge concerning sociopathic or antisocial personality disorder and drug dependence, abuse, and/or addiction. These overlapping arenas provide a microcosm within which to explore the larger shift of postwar psychiatric epidemiology from community studies based on psychological scales to studies based on specific diagnostic criteria. This paper places the figure of sociologist Lee Nelken Robins within the context of the Department of Psychiatry in the School of Medicine at Washington University in St Louis, Missouri. The St Louis research group--to which Robins was both marginal and central--developed the basis for specific diagnostic criteria and was joined by Robert Spitzer, Jean Endicott and other architects of DSM-III in reorienting American psychiatry towards medical, biological and epidemiological models. Robins was a key linchpin working at the nexus of the psychiatric epidemiological and sociological drug addiction research networks. This article situates her work within the broader set of societal and governmental transformations leading to the technologically sophisticated turn in American psychiatric epidemiology and research on the aetiology of drug abuse and mental health and illness. Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2013; all rights reserved.

  9. The other Higgses, at resonance, in the Lee-Wick extension of the Standard Model

    CERN Document Server

    Figy, Terrance

    2011-01-01

    Within the framework of the Lee Wick Standard Model (LWSM) we investigate Higgs pair production $gg \\to h_0 h_0$, $gg \\to h_0 \\tilde p_0$ and top pair production $gg \\to \\bar tt$ at the Large Hadron Collider (LHC), where the neutral particles from the Higgs sector ($h_0$, $\\tilde h_0$ and $\\tilde p_0$) appear as possible resonant intermediate states. We investigate the signal $gg \\to h_0 h_0 \\to \\bar b b \\gamma \\gamma$ and we find that the LW Higgs, depending on its mass-range, can be seen not long after the LHC upgrade in 2012. More precisely this happens when the new LW Higgs states are below the top pair threshold. In $gg \\to \\bar tt$ the LW states, due to the wrong-sign propagator and negative width, lead to a dip-peak structure instead of the usual peak-dip structure which gives a characteristic signal especially for low-lying LW Higgs states. We comment on the LWSM and the forward-backward asymmetry in view of the measurement at the TeVatron. Furthermore, we present a technique which reduces the hyperbo...

  10. The Stories We Hear, the Stories We Tell What Can the Life of Jane Barker (1652-1732) Tell Us about Women's Leadership in Higher Education in the Twenty-First Century?

    Science.gov (United States)

    Wilson, Carol Shiner

    2009-01-01

    Jane Barker--poet, novelist, farm manager, student and practitioner of medical arts--was not allowed to attend university because she was a woman. Yet she was Oxford-educated in the most modern of medical theories of her time. By the end of her life, unmarried by choice, Barker was writing for pay under her own name in an emerging genre--the…

  11. Details of the general numerical solutions of the Friedberg-Lee soliton model for ground and exited states

    International Nuclear Information System (INIS)

    Koeppel, T.; Harvey, M.

    1984-06-01

    A new numerical method is applied to solving the equations of motion of the Friedberg-Lee Soliton model for both ground and spherically symmetric excited states. General results have been obtained over a wide range of parameters. Critical coupling constants and critical particle numbers have been determined below which soliton solutions cease to exist. The static properties of the proton are considered to show that as presently formulated the model fails to fit all experimental data for any set of parameters

  12. Validation of a French adaptation of the Harvard Trauma Questionnaire among torture survivors from sub-Saharan African countries

    Directory of Open Access Journals (Sweden)

    Capucine de Fouchier

    2012-12-01

    Full Text Available Background: To date no validated instrument in the French language exists to screen for posttraumatic stress disorder (PTSD in survivors of torture and organized violence. Objective: The aim of this study is to adapt and validate the Harvard Trauma Questionnaire (HTQ to this population. Method: The adapted version was administered to 52 French-speaking torture survivors, originally from sub-Saharan African countries, receiving psychological treatment in specialized treatment centers. A structured clinical interview for DSM was also conducted in order to assess if they met criteria for PTSD. Results: Cronbach's alpha coefficient for the HTQ Part 4 was adequate (0.95. Criterion validity was evaluated using receiver operating characteristic curve analysis that generated good classification accuracy for PTSD (0.83. At the original cut-off score of 2.5, the HTQ demonstrated high sensitivity and specificity (0.87 and 0.73, respectively. Conclusion: Results support the reliability and validity of the French version of the HTQ.

  13. Validation of a French adaptation of the Harvard Trauma Questionnaire among torture survivors from sub-Saharan African countries

    Science.gov (United States)

    de Fouchier, Capucine; Blanchet, Alain; Hopkins, William; Bui, Eric; Ait-Aoudia, Malik; Jehel, Louis

    2012-01-01

    Background To date no validated instrument in the French language exists to screen for posttraumatic stress disorder (PTSD) in survivors of torture and organized violence. Objective The aim of this study is to adapt and validate the Harvard Trauma Questionnaire (HTQ) to this population. Method The adapted version was administered to 52 French-speaking torture survivors, originally from sub-Saharan African countries, receiving psychological treatment in specialized treatment centers. A structured clinical interview for DSM was also conducted in order to assess if they met criteria for PTSD. Results Cronbach's alpha coefficient for the HTQ Part 4 was adequate (0.95). Criterion validity was evaluated using receiver operating characteristic curve analysis that generated good classification accuracy for PTSD (0.83). At the original cut-off score of 2.5, the HTQ demonstrated high sensitivity and specificity (0.87 and 0.73, respectively). Conclusion Results support the reliability and validity of the French version of the HTQ. PMID:23233870

  14. Posttraumatic stress disorder among refugees: Measurement invariance of Harvard Trauma Questionnaire scores across global regions and response patterns.

    Science.gov (United States)

    Rasmussen, Andrew; Verkuilen, Jay; Ho, Emily; Fan, Yuyu

    2015-12-01

    Despite the central role of posttraumatic stress disorder (PTSD) in international humanitarian aid work, there has been little examination of the measurement invariance of PTSD measures across culturally defined refugee subgroups. This leaves mental health workers in disaster settings with little to support inferences made using the results of standard clinical assessment tools, such as the severity of symptoms and prevalence rates. We examined measurement invariance in scores from the most widely used PTSD measure in refugee populations, the Harvard Trauma Questionnaire (HTQ; Mollica et al., 1992), in a multinational and multilingual sample of asylum seekers from 81 countries of origin in 11 global regions. Clustering HTQ responses to justify grouping regional groups by response patterns resulted in 3 groups for testing measurement invariance: West Africans, Himalayans, and all others. Comparing log-likelihood ratios showed that while configural invariance seemed to hold, metric and scalar invariance did not. These findings call into question the common practice of using standard cut-off scores on PTSD measures across culturally dissimilar refugee populations. In addition, high correlation between factors suggests that the construct validity of scores from North American and European measures of PTSD may not hold globally. (c) 2015 APA, all rights reserved).

  15. Dosimetry for ocular proton beam therapy at the Harvard Cyclotron Laboratory based on the ICRU Report 59

    International Nuclear Information System (INIS)

    Newhauser, W.D.; Burns, J.; Smith, A.R.

    2002-01-01

    The Massachusetts General Hospital, the Harvard Cyclotron Laboratory (HCL), and the Massachusetts Eye and Ear Infirmary have treated almost 3000 patients with ocular disease using high-energy external-beam proton radiation therapy since 1975. The absorbed dose standard for ocular proton therapy beams at HCL was based on a fluence measurement with a Faraday cup (FC). A majority of proton therapy centers worldwide, however, use an absorbed dose standard that is based on an ionization chamber (IC) technique. The ion chamber calibration is deduced from a measurement in a reference 60 Co photon field together with a calculated correction factor that takes into account differences in a chamber's response in 60 Co and proton fields. In this work, we implemented an ionization chamber-based absolute dosimetry system for the HCL ocular beamline based on the recommendations given in Report 59 by the International Commission on Radiation Units and Measurements. Comparative measurements revealed that the FC system yields an absorbed dose to water value that is 1.1% higher than was obtained with the IC system. That difference is small compared with the experimental uncertainties and is clinically insignificant. In June of 1998, we adopted the IC-based method as our standard practice for the ocular beam

  16. The Harvard Beat Assessment Test (H-BAT: A Battery for Assessing Beat Perception and Production and their Dissociation

    Directory of Open Access Journals (Sweden)

    Shinya eFujii

    2013-11-01

    Full Text Available Humans have the abilities to perceive, produce, and synchronize with a musical beat, yet there are widespread individual differences. To investigate these abilities and to determine if a dissociation between beat perception and production exists, we developed the Harvard Beat Assessment Test (H-BAT, a new battery that assesses beat perception and production abilities. H-BAT consists of four subtests: 1 music tapping test (MTT, 2 beat saliency test (BST, 3 beat interval test (BIT, and 4 beat finding and interval test (BFIT. MTT measures the degree of tapping synchronization with the beat of music, whereas BST, BIT, and BFIT measure perception and production thresholds via psychophysical adaptive stair-case methods. We administered the H-BAT on thirty individuals and investigated the performance distribution across these individuals in each subtest. There was a wide distribution in individual abilities to tap in synchrony with the beat of music during the MTT. The degree of synchronization consistency was negatively correlated with thresholds in the BST, BIT, and BFIT: a lower degree of synchronization was associated with higher perception and production thresholds. H-BAT can be a useful tool in determining an individual’s ability to perceive and produce a beat within a single session.

  17. Evaluation of environmental filtration control of engineered nanoparticles using the Harvard Versatile Engineered Nanomaterial Generation System (VENGES)

    Science.gov (United States)

    Echevarría-Vega, Manuel E.; Sotiriou, Georgios A.; Santeufemio, Christopher; Schmidt, Daniel; Demokritou, Philip; Ellenbecker, Michael

    2013-01-01

    Applying engineering controls to airborne engineered nanoparticles (ENPs) is critical to prevent environmental releases and worker exposure. This study evaluated the effectiveness of two air sampling and six air cleaning fabric filters at collecting ENPs using industrially relevant flame-made engineered nanoparticles generated using a versatile engineered nanomaterial generation system (VENGES), recently designed and constructed at Harvard University. VENGES has the ability to generate metal and metal oxide exposure atmospheres while controlling important particle properties such as primary particle size, aerosol size distribution, and agglomeration state. For this study, amorphous SiO2 ENPs with a 15.4 nm primary particle size were generated and diluted with HEPA-filtered air. The aerosol was passed through the filter samples at two different filtration face velocities (2.3 and 3.5 m/min). Particle concentrations as a function of particle size were measured upstream and downstream of the filters using a specially designed filter test system to evaluate filtration efficiency. Real time instruments (FMPS and APS) were used to measure particle concentration for diameters from 5 to 20,000 nm. Membrane-coated fabric filters were found to have enhanced nanoparticle collection efficiency by 20–46 % points compared to non-coated fabric and could provide collection efficiency above 95 %. PMID:23412707

  18. Neuropsychological Functioning in Adolescents and Young Adults at Genetic Risk for Schizophrenia and Affective Psychoses: Results from the Harvard and Hillside Adolescent High Risk Studies

    OpenAIRE

    Seidman, Larry J.; Giuliano, Anthony J.; Smith, Christopher W.; Stone, William S.; Glatt, Stephen J.; Meyer, Eric; Faraone, Stephen V.; Tsuang, Ming T.; Cornblatt, Barbara

    2006-01-01

    Siblings and offspring of persons with schizophrenia carry elevated genetic risk for the illness and manifest attentional and memory impairments. Because less is known about other neuropsychological functions and their specificity in adolescents, we conducted a genetic high-risk (HR) study of schizophrenia (HR-SCZ) and affective psychosis (HR-AFF). Participants (ages 12–25) were from the Harvard Adolescent High-Risk and Hillside Family studies, including 73 HR-SCZ, 18 HR-AFF, and 84 community...

  19. Playing with Quantum Toys: Julian Schwinger's Measurement Algebra and the Material Culture of Quantum Mechanics Pedagogy at Harvard in the 1960s

    Science.gov (United States)

    Gauvin, Jean-François

    2018-03-01

    In the early 1960s, a PhD student in physics, Costas Papaliolios, designed a simple—and playful—system of Polaroid polarizer filters with a specific goal in mind: explaining the core principles behind Julian Schwinger's quantum mechanical measurement algebra, developed at Harvard in the late 1940s and based on the Stern-Gerlach experiment confirming the quantization of electron spin. Papaliolios dubbed his invention "quantum toys." This article looks at the origins and function of this amusing pedagogical device, which landed half a century later in the Collection of Historical Scientific Instruments at Harvard University. Rendering the abstract tangible was one of Papaliolios's demonstration tactics in reforming basic teaching of quantum mechanics. This article contends that Papaliolios's motivation in creating the quantum toys came from a renowned endeavor aimed, inter alia, at reforming high-school physics training in the United States: Harvard Project Physics. The pedagogical study of these quantum toys, finally, compels us to revisit the central role playful discovery performs in pedagogy, at all levels of training and in all fields of knowledge.

  20. Going beyond "First Impressions": Jane Austen on the spotlightDOI:10.5007/2175-8026.2010n59p101

    Directory of Open Access Journals (Sweden)

    Carla Alexandra Ferreira

    2010-03-01

    Full Text Available The last decades has seen a proliferation of Jane Austen’s novels for television and cinema. Despite being an important movement for the popularity of her literary work that has also brought some problems for a serious understanding of Austen’s literary project. The purpose of this essay is to point out the need of considering the changes, preferences and omissions, apparently not very important or carried out because of some demands of the translation from a novel to the cinema, that occur when her work is revisited. We will try to show some choices made in the transference from her novels to film may erase part of the writer’s fictional project which is among other things to portray women’s role in the nineteenth century patriarchal English society and try to change women’s condition of invisibility that had been created and spread since Enlightenment. In order to illustrate our point the 2005 version of Pride and Prejudice for the cinema will be used.

  1. P. R. Moore-Dewey’s “Pregiudizio e Orgoglio”: An Italian Remake of Jane Austen’s “Pride and Prejudice”

    Directory of Open Access Journals (Sweden)

    Eleonora Capra

    2017-12-01

    Full Text Available Since its publication in 1814, Jane Austen’s most famous novel, Pride and Prejudice, has enjoyed great success and has been the object of countless re-workings, re-mediations and adaptations on global scale. This essay aims at discussing a special instance of this phenomenon: an Italian re-make entitled Pregiudizio e Orgoglio (2012 and written by Austen enthusiast and admirer, P. R. Moore-Dewey (pseudonym of Patrizia Murreddu. I intend to analyze the change of perspective adopted by the author, who decided to re-write Austen's tale through the point of view of Mr. Darcy and his sister Georgiana. Moreover, it is my intention to look at some of the many intertextual references present in Moore-Dewey’s work and consider the impact of such references and quotations on the reading experience. Finally, I will consider the extensive use of paratextual devices, which contribute to define this work a particularly relevant literary manifestation.

  2. “WEALTH OR LOVE, WHAT DOES A WOMAN WANT?” AN IRONIC LOOK AT THE MIDDLE CLASS NORMS IN CHARLOTTE BRONTE’S JANE EYRE

    Directory of Open Access Journals (Sweden)

    Afina Murtiningrum

    2017-02-01

    Full Text Available Jane Eyre is a novel written in the early nineteenth century (1847. It depicts the English society of the upper, middle and lower class and their habits and attitudes towards life. The opening of the novel points to social class, wealth and marriage as its major theme. Throughout the novel, the relationship between social awareness of class and marriage, especially dealing with money or property are highlighted, the reason why society tends to consider about social class, money and property in finding a suitable partner to marry. This paper relies on the examples from the novel to show how nineteenth-century women imagined their marriage. In terms of women’s social rights and roles, Charlotte Bronte tries to open readers' eyes to the idea that women's abilities should not be limited only to the sphere of the family. Bronte’s novel does not only attack Victorian class structure but also the issue of gender.   Keywords : marriage, wealth, property, women’s roles, gender

  3. The Mystery of the Past Haunts Again: Jane Eyre and Eugenie Marlitt’s Die zweite Frau Le mystère du passé hante encore: l’influence de Jane Eyre sur Die zweite Frau d’Eugenie Marlitt

    Directory of Open Access Journals (Sweden)

    Ivonne Defant

    2010-03-01

    Full Text Available Charlotte Brontë’s Jane Eyre is a classic in women’s fiction. When it was published in 1847, it made an immediate impact in mid-Victorian England, partly because it drew on the paradigmatic story of a romance heroine, partly because it interpreted the needs of the women of the time. Since then, the Thornfield Hall attic where Bertha Mason is kept hidden by the master of the house, Mr. Rochester, has become the metaphor of a feminine place of imprisonment and,at the same time, of rebellion against patriarchal rules.About thirty years after Jane Eyre, another woman writer published a book which evokes the haunting atmosphere of the Thornfield Hall theme, i.e., the German writer Eugenie Marlitt, the author of Die zweite Frau ( The second wife, 1874.Interestingly, Marlitt seems to recapture, while rewriting it, the character of Bertha within the context of German domestic fiction. Bothnovels explore indeed the issue of the imprisoned and socially marginalised woman in terms of ethnicity to show how gender roles are inevitably complicit with power relations. In Jane Eyre and Die zweite Frau the house motif is a pivotal element that leads to our understanding of the female characters, but it is above all the mystery that reverberates through the houses of the two novels, represented by two women, the Creole Bertha  and the Indian Lotusblume, which, being crucial to the articulation of the discursive thrust underlying the two narratives, discloses the multi-layered construction of femininity.Jane Eyre de Charlotte Brontë est un classique de la littérature féminine. Lors de sa publication en 1847, le roman eut un impact immédiat sur l’Angleterre victorienne, d’une part parce qu’il racontait l’histoire paradigmatique d’une héroïne de romance et d’autre part parce qu’il se faisait l’interprète des désirs des femmes de l’époque. Depuis, le grenier de Thornfield Hall où le maître de maison cache Bertha Mason, est devenu la

  4. Academic-industrial relations before the blockbuster drugs: lessons from the Harvard Committee on Pharmacotherapy, 1939-1943.

    Science.gov (United States)

    Podolsky, Scott H; Greene, Jeremy A

    2011-04-01

    Increasing discussion has developed in recent years over the nature of the relationship between academic medicine and the pharmaceutical industry. This article narrates the history of a little-known attempt at Harvard Medical School between 1939 and 1943 to establish an interdisciplinary, academic-industrial Committee on Pharmacotherapy to enhance and rationalize the relationship between the field of academic research in pharmacotherapeutics and the pharmaceutical industry. Using original archival materials, the authors depict the functioning of the committee, which was headed by Soma Weiss and included such members as Fuller Albright, Henry Beecher, and Walter Cannon. The committee would be collectively funded by seven pharmaceutical companies and was to be predicated on collaboration, both across the entire university and between academia and industry. It was expected to transform the bench-to-bedside study and testing of therapeutic compounds, to redefine the teaching of pharmacotherapy, and to create a unified forum through which to discuss the overall academic-industrial relationship and more specific issues such as patents. Unfortunately, the program proved to be short-lived, the victim of such contingent factors as the untimely death of Soma Weiss and America's entry into World War II, as well as such more fundamental factors as the inadequate and temporary nature of the funding stream and unresolved tensions regarding the goals of the committee on the part of both the medical school and its industry supporters. Nevertheless, these early forays into collaborative bench-to-bedside translational research and the rationalization of academic-industrial relations remain instructive today. © by the Association of American Medical Colleges.

  5. The Harvard Automated Processing Pipeline for Electroencephalography (HAPPE): Standardized Processing Software for Developmental and High-Artifact Data.

    Science.gov (United States)

    Gabard-Durnam, Laurel J; Mendez Leal, Adriana S; Wilkinson, Carol L; Levin, April R

    2018-01-01

    Electroenchephalography (EEG) recordings collected with developmental populations present particular challenges from a data processing perspective. These EEGs have a high degree of artifact contamination and often short recording lengths. As both sample sizes and EEG channel densities increase, traditional processing approaches like manual data rejection are becoming unsustainable. Moreover, such subjective approaches preclude standardized metrics of data quality, despite the heightened importance of such measures for EEGs with high rates of initial artifact contamination. There is presently a paucity of automated resources for processing these EEG data and no consistent reporting of data quality measures. To address these challenges, we propose the Harvard Automated Processing Pipeline for EEG (HAPPE) as a standardized, automated pipeline compatible with EEG recordings of variable lengths and artifact contamination levels, including high-artifact and short EEG recordings from young children or those with neurodevelopmental disorders. HAPPE processes event-related and resting-state EEG data from raw files through a series of filtering, artifact rejection, and re-referencing steps to processed EEG suitable for time-frequency-domain analyses. HAPPE also includes a post-processing report of data quality metrics to facilitate the evaluation and reporting of data quality in a standardized manner. Here, we describe each processing step in HAPPE, perform an example analysis with EEG files we have made freely available, and show that HAPPE outperforms seven alternative, widely-used processing approaches. HAPPE removes more artifact than all alternative approaches while simultaneously preserving greater or equivalent amounts of EEG signal in almost all instances. We also provide distributions of HAPPE's data quality metrics in an 867 file dataset as a reference distribution and in support of HAPPE's performance across EEG data with variable artifact contamination and

  6. The Harvard Automated Processing Pipeline for Electroencephalography (HAPPE: Standardized Processing Software for Developmental and High-Artifact Data

    Directory of Open Access Journals (Sweden)

    Laurel J. Gabard-Durnam

    2018-02-01

    Full Text Available Electroenchephalography (EEG recordings collected with developmental populations present particular challenges from a data processing perspective. These EEGs have a high degree of artifact contamination and often short recording lengths. As both sample sizes and EEG channel densities increase, traditional processing approaches like manual data rejection are becoming unsustainable. Moreover, such subjective approaches preclude standardized metrics of data quality, despite the heightened importance of such measures for EEGs with high rates of initial artifact contamination. There is presently a paucity of automated resources for processing these EEG data and no consistent reporting of data quality measures. To address these challenges, we propose the Harvard Automated Processing Pipeline for EEG (HAPPE as a standardized, automated pipeline compatible with EEG recordings of variable lengths and artifact contamination levels, including high-artifact and short EEG recordings from young children or those with neurodevelopmental disorders. HAPPE processes event-related and resting-state EEG data from raw files through a series of filtering, artifact rejection, and re-referencing steps to processed EEG suitable for time-frequency-domain analyses. HAPPE also includes a post-processing report of data quality metrics to facilitate the evaluation and reporting of data quality in a standardized manner. Here, we describe each processing step in HAPPE, perform an example analysis with EEG files we have made freely available, and show that HAPPE outperforms seven alternative, widely-used processing approaches. HAPPE removes more artifact than all alternative approaches while simultaneously preserving greater or equivalent amounts of EEG signal in almost all instances. We also provide distributions of HAPPE's data quality metrics in an 867 file dataset as a reference distribution and in support of HAPPE's performance across EEG data with variable artifact

  7. Comparison of Elastic Modulus and Compressive Strength of Ariadent and Harvard Polycarboxylate Cement and Vitremer Resin Modified Glass Ionomer

    Directory of Open Access Journals (Sweden)

    Ahmadian Khoshemehr Leila

    2009-09-01

    Full Text Available Background: Luting agents are used to attach indirect restoration into or on the tooth. Poor mechanical properties of cement may be a cause of fracture of this layer and lead to caries and restoration removal. The purpose of this study was to compare the elastic modulus and compressive strength of Ariadent (A Poly and Harvard polycarboxylate (H Poly cements and Vitremer resin modified glass ionomer (RGl.Materials & Methods: In this experimental study 15 specimens were prepared form each experimental cement in Laboratory of Tehran Oil Refining Company. The cylindrical specimens were compressed in Instron machine after 24 hours. Elastic modulus and compressive strength were calculated from stress/strain curve of each specimen. One way ANOVA and Tukey tests were used for statistical analysis and P values<0.05 were considered to be statistically significant.Results: The mean elastic modulus and mean compressive strength were 2.2 GPa and 87.8MPa in H poly, 2.4 GPa and 56.5 MPa in A Poly, and 0.8GPa and 105.6 MPa in RGI, respectively. Statistical analysis showed that compressive strength and elastic modulus of both polycarboxylate cements were significantly different from hybrid ionomer (P<0.05, but the difference between elastic modulus of two types of polycarboxilate cements was not statistically significant. Compressive strength of two polycarboxilate cements were significantly different (P<0.05. Conclusion: An ideal lutting agent must have the best mechanical properties. Between the tested luttins RGl cement had the lowest elastic modulus and the highest compressive strength, but the A poly cement had the highest elastic modulus and the lowest compressive strength. Therefore none of them was the best.

  8. Diurnal variability of inner-shelf circulation in the lee of a cape under upwelling conditions

    Science.gov (United States)

    Lamas, L.; Peliz, A.; Dias, J.; Oliveira, P. B.; Angélico, M. M.; Castro, J. J.; Fernandes, J. N.; Trindade, A.; Cruz, T.

    2017-07-01

    The nearshore circulation in the lee of a cape under upwelling conditions was studied using in-situ data from 3 consecutive summers (2006-2008). Focus was given to a period between 20 July and 04 August 2006 to study the diurnal variability of the cross-shelf circulation. This period was chosen because it had a steady upwelling-favourable wind condition modulated by a diurnal cycle much similar to sea breeze. The daily variability of the observed cross-shelf circulation consisted of three distinct periods: a morning period with a 3-layer vertical structure with onshore velocities at mid-depth, a mid-day period where the flow is reversed and has a 2-layer structure with onshore velocities at the surface and offshore flow below, and, lastly, in the evening, a 2-layer period with intensified offshore velocities at the surface and onshore flow at the bottom. The observed cross-shelf circulation showed a peculiar vertical shape and diurnal variability different from several other systems described in literature. We hypothesize that the flow reversal of the cross-shelf circulation results as a response to the rapid change of the wind magnitude and direction at mid-day with the presence of the cape north of the mooring site influencing this response. A numerical modelling experiment exclusively forced by winds simulated successfully most of the circulation at the ADCP site, especially the mid-day reversal and the evening's upwelling-type structure. This supports the hypothesis that the cross-shelf circulation at diurnal timescales is mostly wind-driven. By analysing the 3D circulation in the vicinity of Cape Sines we came to the conclusion that the diurnal variability of the wind and the flow interaction with topography are responsible for the circulation variability at the ADCP site, though only a small region in the south of the cape showed a similar diurnal variability. The fact that the wind diurnally undergoes relaxation and intensification strongly affects the

  9. "Embodiment as procedures: Physical cleansing changes goal priming effects": Correction to Dong and Lee (2017).

    Science.gov (United States)

    2017-06-01

    Reports an error in "Embodiment as procedures: Physical cleansing changes goal priming effects" by Ping Dong and Spike W. S. Lee ( Journal of Experimental Psychology: General , 2017[Apr], Vol 146[4], 592-605). In the article, the following F-value and p-values in the Results section of Experiment 3 were set incorrectly: The p -value p =.925 should be p =.922. The F - and p -values F (1, 201)=.011, p =.916 should be F (1, 201) .014, p = .906. (The following abstract of the original article appeared in record 2017-14922-010.) Physical cleansing reduces the influence of numerous psychological experiences, such as guilt from immoral behavior, dissonance from free choice, and good/bad luck from winning/losing. How do these domain-general effects occur? We propose an integrative account of cleansing as an embodied procedure of psychological separation. By separating physical traces from a physical target object (e.g., detaching dirt from hands), cleansing serves as the embodied grounding for the separation of psychological traces from a psychological target object (e.g., dissociating prior experience from the present self). This account predicts that cleansing reduces the accessibility of psychological traces and their consequences for judgments and behaviors. Testing these in the context of goal priming, we find that wiping one's hands (vs. not) decreases the mental accessibility (Experiment 1), behavioral expression (Experiment 2), and judged importance (Experiments 3-4) of previously primed goals (e.g., achievement, saving, fitness). But if a goal is primed after cleansing, its importance gets amplified instead (Experiment 3). Based on the logic of moderation-of-process, an alternative manipulation that psychologically separates a primed goal from the present self produces the same effects, but critically, the effects vanish once people wipe their hands clean (Experiment 4), consistent with the notion that cleansing functions as an embodied procedure of psychological

  10. The Harvard University Herbarium

    NARCIS (Netherlands)

    Howard, Richard A.

    1955-01-01

    During 1954 the Gray Herbarium, the Orchid Herbarium of Oakes Ames, the paleobotanical collections of the Botanical Museum and a portion of the herbarium collections and the library of the Arnold Arboretum were moved into a new building in Cambridge, Massachusetts. This move was the culmination of a

  11. Zatlers addresses Harvard audience

    Index Scriptorium Estoniae

    2010-01-01

    Läti presidendi Valdis Zatlersi Harvardi ülikoolis peetud kõnest, milles ta märgib, et üks tema jaoks tähtsamatest küsimustest on, kes võiks Läti uue peaministrina riigi praegust majanduskurssi jätkata, ja leiab, et Läti kuulub oma rahvaarvu arvestades Afganistani enam panustavate riikide hulka

  12. Amino acid residues in the Ler protein critical for derepression of the LEE5 promoter in enteropathogenic E. coli.

    Science.gov (United States)

    Choi, Su-Mi; Jeong, Jae-Ho; Choy, Hyon E; Shin, Minsang

    2016-08-01

    Enteropathogenic E. coli causes attaching and effacing (A/E) intestinal lesions. The genes involved in the formation of A/E lesions are encoded within a chromosomal island comprising of five major operons, LEE1-5. The global regulator H-NS represses the expression of these operons. Ler, a H-NS homologue, counteracts the H-NS-mediated repression. Using a novel genetic approach, we identified the amino acid residues in Ler that are involved in the interaction with H-NS: I20 and L23 in the C-terminal portion of α-helix 3, and I42 in the following unstructured linker region.

  13. A linear model for rotors produced by trapped lee waves with a simple representation of boundary layer friction

    Science.gov (United States)

    Teixeira, Miguel A. C.

    2017-04-01

    A linear model is used to diagnose the onset of rotors in flow over 2D ridges, for atmospheres that are neutrally stratified near the surface and stably stratified aloft, with a sharp temperature inversion in between, where trapped lee waves may propagate. This is achieved by coupling an inviscid two-layer mountain-wave model with a bulk boundary-layer model. The full model shows some ability to detect flow stagnation as a function of key input parameters, such as the Froude number and the height of the inversion, by comparison with results from numerical simulations and laboratory experiments carried out by previous authors. The effect of a boundary layer is essential to correctly predict flow stagnation, as the inviscid version of the model severely overestimates the dimensionless critical mountain height necessary for stagnation to occur. An improved model that includes only the effects of mean flow deceleration and amplification of the velocity perturbation within the boundary layer predicts flow stagnation much better in the most non-hydrostatic cases treated here, where waves appear to be directly forced by the orography. However, in the most hydrostatic case, only the full model, taking into account the feedback of the boundary layer on the inviscid flow, satisfactorily predicts flow stagnation, although the corresponding stagnation condition is unable to discriminate between rotors and hydraulic jumps. This is due to the fact that the trapped lee waves associated with the rotors are not forced directly by the orography in this case, but rather seem to be generated indirectly by nonlinear processes. This mechanism is, to a certain extent, mimicked by the modified surface boundary condition adopted in the full model, where an "effective orography" that differs from the real one forces the trapped lee waves. Versions of the model not including this feedback severely underestimate the amplitude of the trapped lee waves in the most hydrostatic case, partly

  14. Okhee Lee, Cory A. Buxton, James A. Banks (ed.), Diversity and equity in science education: research, policy, and practice

    Science.gov (United States)

    Bannier, Betsy J.

    2015-06-01

    Highly relevant for academic study among K-12 educators and the higher education faculty who train pre-service teachers, Diversity and equity in science education highlights three interrelated issues impacting science education in the United States. First, complicated dynamics related to the large and increasing population of English language learning (ELL) students are discussed. Second, the realities of standardized test scores are comparatively explored, both within and beyond the United States. Third, the politics of accountability in education are vigorously discussed. Okhee Lee and Cory A. Buxton weave through the contexts of politics, education, science, and culture to expand existing discourse about how to best educate our nation's children.

  15. Esse tal de Roque Enrow! : a trajetória de Rita Lee de outsider ao mainstream (1967-1985)

    OpenAIRE

    Gohl, Jeffferson William

    2014-01-01

    O presente trabalho acompanhou parte da trajetória da artista Rita Lee Jones no período entre 1967 até 1985. Valendo-se de fontes, discográficas, documentos audiovisuais, documentos de arquivo e discursos produzidos pela imprensa, procurou documentar desde o momento contracultural em que ela participou do grupo Os Mutantes junto aos movimentos da Tropicália, até seu momento de reconhecimento de maturidade artística que ocorre concomitante ao término do Regime Militar autoritário no Brasil. ...

  16. Innovative curriculum for second-year Harvard-MIT medical students: practicing communication skills with volunteer patients giving immediate feedback

    Directory of Open Access Journals (Sweden)

    Ali NB

    2017-05-01

    Full Text Available Nadaa B Ali,1 Stephen R Pelletier,2 Helen M Shields1 1Department of Medicine, Brigham and Women’s Hospital, 2Center for Evaluation, Harvard Medical School, Boston, MA, USA Purpose: Medical students are expected to develop excellent communication skills. The purpose of our study was to create an innovative communication skills exercise using real volunteer patients and physician co-teachers for students to practice communication skills while receiving immediate feedback.Method: This is a mixed methods study where second-year medical students participated in the communication skills exercise with real patients and physician co-teachers giving immediate feedback. Clinical scenarios reflected the patients’ actual experiences. Students acted out roles as physicians. Physicians co-taught with the patients and gave immediate feedback to students. Students completed an anonymous written survey at the end of the exercise. Qualitative and quantitative responses were recorded. Student feedback from the 2014 surveys was used to modify the teaching designs to increase active role play opportunities by having only two students in each group and doubling the number of stations with real patients.Results: Students rated the overall exercise and the utility of patient volunteers in learning how to communicate on a Likert scale of 1–5, where in this medical school traditionally 1 is excellent and 5 is poor. In 2014, the exercises were rated with a mean score of 1.47 (SD 0.621. In 2015, the exercises were rated with a mean score of 1.03 (SD 0.62. In 2016, the exercises were rated with a mean score of 1.27 (SD 0.52. ANOVA analysis (p=0.002 and Bonferroni corrections indicate a statistically significant difference between combined mean scores of the exercise in 2014 and 2015 (p=0.001. No difference was shown between 2014 and 2016 or 2015 and 2016.Conclusions: Medical students rated practicing communication skills with real patient volunteers and physician co

  17. INFECTADA POR LA EMOCIÓN: LA MÚSICA DE JANE BADLER Y LA MADURACIÓN DE DIANA EN LA SERIE V (1983-2011

    Directory of Open Access Journals (Sweden)

    Gerardo Rodríguez Salas

    2014-10-01

    Full Text Available Es una verdad universalmente conocida que una sola disciplina es insuficiente para cubrir el alcance de la cultura como un todo (Johnson, 1986: 279. Como padre fundador de los estudios culturales, Raymond Williams definía este campo como “a vague and baggy monster” (1989: 158 que demanda una aproximación interdisciplinaria. Consciente del prejuicio que el estudio de las series televisivas de ciencia ficción despierta en el mundo académico, el presente estudio se adentra en el reto de analizar, desde una perspectiva de Estudios Culturales, la popular serie V, que combina elementos de ciencia ficción y de telenovela para hacerse con el interés del espectador. Se explorará este tándem teniendo en cuenta su limitación patriarcal de la agencia femenina tras una apariencia de empoderamiento de sus mujeres. En oposición a estos discursos, una de las protagonistas de la serie, Jane Badler (Diana, finalmente alcanza un efecto paródico a través del discurso alternativo de la música, donde transciende el cliché de heroínas/villanas en la ciencia ficción audiovisual—e.g. Ripley en la saga Alien, Helena Cain en Battlestar Galactica: Reimagined o Elizabeth Shaw y Meredith Vickers en la reciente Prometheus. Aunque mayoritariamente compuesta por varones, la música paródica de Badler, así como sus actuaciones y autoconsciencia satírica, ofrecen un espacio alternativo a la ciencia ficción, que sistemáticamente cierra la puerta al empoderamiento femenino.

  18. Evaluating the performance of the Lee-Carter method and its variants in modelling and forecasting Malaysian mortality

    Science.gov (United States)

    Zakiyatussariroh, W. H. Wan; Said, Z. Mohammad; Norazan, M. R.

    2014-12-01

    This study investigated the performance of the Lee-Carter (LC) method and it variants in modeling and forecasting Malaysia mortality. These include the original LC, the Lee-Miller (LM) variant and the Booth-Maindonald-Smith (BMS) variant. These methods were evaluated using Malaysia's mortality data which was measured based on age specific death rates (ASDR) for 1971 to 2009 for overall population while those for 1980-2009 were used in separate models for male and female population. The performance of the variants has been examined in term of the goodness of fit of the models and forecasting accuracy. Comparison was made based on several criteria namely, mean square error (MSE), root mean square error (RMSE), mean absolute deviation (MAD) and mean absolute percentage error (MAPE). The results indicate that BMS method was outperformed in in-sample fitting for overall population and when the models were fitted separately for male and female population. However, in the case of out-sample forecast accuracy, BMS method only best when the data were fitted to overall population. When the data were fitted separately for male and female, LCnone performed better for male population and LM method is good for female population.

  19. Analyses and optimization of Lee propagation model for LoRa 868 MHz network deployments in urban areas

    Directory of Open Access Journals (Sweden)

    Dobrilović Dalibor

    2017-01-01

    Full Text Available In the recent period, fast ICT expansion and rapid appearance of new technologies raised the importance of fast and accurate planning and deployment of emerging communication technologies, especially wireless ones. In this paper is analyzed possible usage of Lee propagation model for planning, design and management of networks based on LoRa 868MHz technology. LoRa is wireless technology which can be deployed in various Internet of Things and Smart City scenarios in urban areas. The analyses are based on comparison of field measurements with model calculations. Besides the analyses of Lee propagation model usability, the possible optimization of the model is discussed as well. The research results can be used for accurate design, planning and for preparation of high-performance wireless resource management of various Internet of Things and Smart City applications in urban areas based on LoRa or similar wireless technology. The equipment used for measurements is based on open-source hardware.

  20. Comparison of Stem Map Developed from Crown Geometry Allometry Linked Census Data to Airborne and Terrestrial Lidar at Harvard Forest, MA

    Science.gov (United States)

    Sullivan, F.; Palace, M. W.; Ducey, M. J.; David, O.; Cook, B. D.; Lepine, L. C.

    2014-12-01

    Harvard Forest in Petersham, MA, USA is the location of one of the temperate forest plots established by the Center for Tropical Forest Science (CTFS) as a joint effort with Harvard Forest and the Smithsonian Institute's Forest Global Earth Observatory (ForestGEO) to characterize ecosystem processes and forest dynamics. Census of a 35 ha plot on Prospect Hill was completed during the winter of 2014 by researchers at Harvard Forest. Census data were collected according to CTFS protocol; measured variables included species, stem diameter, and relative X-Y locations. Airborne lidar data were collected over the censused plot using the high spatial resolution Goddard LiDAR, Hyperspectral, and Thermal sensor package (G-LiHT) during June 2012. As part of a separate study, 39 variable radius plots (VRPs) were randomly located and sampled within and throughout the Prospect Hill CTFS/ForestGEO plot during September and October 2013. On VRPs, biometric properties of trees were sampled, including species, stem diameter, total height, crown base height, crown radii, and relative location to plot centers using a 20 Basal Area Factor prism. In addition, a terrestrial-based lidar scanner was used to collect one lidar scan at plot center for 38 of the 39 VRPs. Leveraging allometric equations of crown geometry and tree height developed from 374 trees and 16 different species sampled on 39 VRPs, a 3-dimensional stem map will be created using the Harvard Forest ForestGEO Prospect Hill census. Vertical and horizontal structure of 3d field-based stem maps will be compared to terrestrial and airborne lidar scan data. Furthermore, to assess the quality of allometric equations, a 2d canopy height raster of the field-based stem map will be compared to a G-LiHT derived canopy height model for the 35 ha census plot. Our automated crown delineation methods will be applied to the 2d representation of the census stem map and the G-LiHT canopy height model. For future work related to this study

  1. Tentative identification of polar and mid-polar compounds in extracts from wine lees by liquid chromatography-tandem mass spectrometry in high-resolution mode.

    Science.gov (United States)

    Delgado de la Torre, M P; Priego-Capote, F; Luque de Castro, M D

    2015-06-01

    Sustainable agriculture has a pending goal in the revalorization of agrofood residues. Wine lees are an abundant residue in the oenological industry. This residue, so far, has been used to obtain tartaric acid or pigments but not for being qualitatively characterized as a source of polar and mid-polar compounds such as flavonoids, phenols and essential amino acids. Lees extracts from 11 Spanish wineries have been analyzed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in high resolution mode. The high-resolution power of LC-MS/MS has led to the tentative identification of the most representative compounds present in wine lees, comprising primary amino acids, anthocyans, flavanols, flavonols, flavones and non-flavonoid phenolic compounds, among others. Attending to the profile and content of polar and mid-polar compounds in wine lees, this study underlines the potential of wine lees as an exploitable source to isolate interesting compounds. Copyright © 2015 John Wiley & Sons, Ltd.

  2. Grey relational analysis for evaluating the effects of different rates of wine lees-derived biochar application on a plant-soil system with multi-metal contamination.

    Science.gov (United States)

    Xu, Min; Zhu, Qihong; Wu, Jun; He, Yan; Yang, Gang; Zhang, Xiaohong; Li, Li; Yu, Xiaoyu; Peng, Hong; Wang, Lilin

    2018-03-01

    In this study, grey relational analysis (GRA) was used to investigate the effects of different application rates of wine lees-derived biochar on a plant-soil system with multi-metal contamination. A pot experiment was conducted to determine rice growth in multi-metal-contaminated soil amended with samples of wine lees-derived biochar, and 47 indicators (including soil properties, microbial activity, and plant physiology) were selected as evaluation indexes to assess the plant-soil system. The results indicated that higher wine lees-derived biochar application rates (2% W/W) were favorable for soil fertility, the bioconcentration factor (BF), and the mobility factor (MF, %) (with the exception of Cr, Zn, and Hg), but an application of 1% produced the highest plant growth, enzymatic activities, and bacterial diversity. The richness of the bacterial communities was reduced in the soil amended with the wine lees-derived biochar. According to the GRA assessment, the 1% application rate of wine lees-derived biochar was more suitable for restoring the holistic plant-soil system than were the application rates of 0, 0.5, and 2% (W/W). Furthermore, this study shows that GRA is a useful method for evaluating plant-soil systems.

  3. Helga-Jane Scarwell et Isabelle Roussel (dir., 2010, Le changement climatique : Quand le climat nous pousse à changer d’ère, Presses Universitaire du Septentrion, Lille, 358 pages

    Directory of Open Access Journals (Sweden)

    Laurence Rocher

    2010-12-01

    Full Text Available L’ouvrage « Le changement climatique. Quand le climat nous pousse à changer d’ère », édité par les Presses Universitaire du Septentrion dans la collection Environnement et société, coordonné par Helga-Jane Scarwell et Isabelle Roussel, rassemble autour de la question du changement climatique plusieurs contributions de chercheurs en géographie, pour la plupart membres du laboratoire TVES de Lille. Ce livre apporte un éclairage original et intéressant, alliant des études de cas comportant un fo...

  4. NsrR, GadE, and GadX interplay in repressing expression of the Escherichia coli O157:H7 LEE pathogenicity island in response to nitric oxide.

    Directory of Open Access Journals (Sweden)

    Priscilla Branchu

    2014-01-01

    Full Text Available Expression of genes of the locus of enterocyte effacement (LEE is essential for adherence of enterohemorrhagic Escherichia coli (EHEC to intestinal epithelial cells. Gut factors that may modulate LEE gene expression may therefore influence the outcome of the infection. Because nitric oxide (NO is a critical effector of the intestinal immune response that may induce transcriptional regulation in enterobacteria, we investigated its influence on LEE expression in EHEC O157:H7. We demonstrate that NO inhibits the expression of genes belonging to LEE1, LEE4, and LEE5 operons, and that the NO sensor nitrite-sensitive repressor (NsrR is a positive regulator of these operons by interacting directly with the RNA polymerase complex. In the presence of NO, NsrR detaches from the LEE1/4/5 promoter regions and does not activate transcription. In parallel, two regulators of the acid resistance pathway, GadE and GadX, are induced by NO through an indirect NsrR-dependent mechanism. In this context, we show that the NO-dependent LEE1 down-regulation is due to absence of NsrR-mediated activation and to the repressor effect of GadX. Moreover, the inhibition of expression of LEE4 and LEE5 by NO is due to loss of NsrR-mediated activation, to LEE1 down-regulation and to GadE up-regulation. Lastly, we establish that chemical or cellular sources of NO inhibit the adherence of EHEC to human intestinal epithelial cells. These results highlight the critical effect of NsrR in the regulation of the LEE pathogenicity island and the potential role of NO in the limitation of colonization by EHEC.

  5. Brown trout in the Lees Ferry reach of the Colorado River—Evaluation of causal hypotheses and potential interventions

    Science.gov (United States)

    Runge, Michael C.; Yackulic, Charles B.; Bair, Lucas S.; Kennedy, Theodore A.; Valdez, Richard A.; Ellsworth, Craig; Kershner, Jeffrey L.; Rogers, R. Scott; Trammell, Melissa A.; Young, Kirk L.

    2018-04-17

    Over the period 2014–2016, the number of nonnative brown trout (Salmo trutta) captured during routine monitoring in the Lees Ferry reach of the Colorado River, downstream of Glen Canyon Dam, began increasing. Management agencies and stakeholders have questioned whether the increase in brown trout in the Lees Ferry reach represents a threat to the endangered humpback chub (Gila cypha), to the rainbow trout (Oncorhynchus mykiss) sport fishery, or to other resources of concern. In this report, we evaluate the evidence for the expansion of brown trout in the Lees Ferry reach, consider a range of causal hypotheses for this expansion, examine the likely efficacy of several potential management interventions to reduce brown trout, and analyze the effects of those interventions on other resources of concern.The brown trout population at Lees Ferry historically consisted of a small number of large fish supported by low levels of immigration from downstream reaches. This population is now showing signs of sustained successful reproduction and is on the cusp of recruiting locally hatched fish into the spawning class, based on analysis with a new integrated population model. The proximate causes of this change in status are a large pulse of immigration in the fall of 2014 and higher reproductive rates in 2015–2017. The ultimate causes of this change are not clear. The pulse of immigrants from downstream reaches in fall 2014 may have been induced by three sequential high-flow releases from the dam in November of 2012–2014, but may also have been the result of a unique set of circumstances unrelated to dam operations. The increase in reproduction may have been the result of any number of changes, including an Allee effect, warmer water temperatures, a decrease in competition from rainbow trout, or fall high-flow releases. Correlations over space and time among predictor variables do not allow us to make a clear inference about the cause of the changes. Under a null causal

  6. The role of upper tropospheric jet streaks and lee-side cyclogenesis in the development of low level jets in the great plains

    Science.gov (United States)

    Uccellini, L. W.

    1980-01-01

    A review of 15 cases of low level jets (LLJ) which developed in the Great Plains is presented. For 12 out of the 15 cases, a systematic upper level flow pattern was isolated which includes the existence of a trough over the southwest United States and the propagation of upper level jet streaks from the Rocky Mountains toward the Great Plains. This flow pattern is responsible for lee side cyclogenesis or lee side troughing that produces the pressure gradients needed for the development of the LLJ. For the other three cases, a blocking ridge existed over the Great Plains and the upper level flow is relatively weak. It is during these situations that the classic, diurnal oscillating LLJ was observed. A more detailed review of four cases indicates that the subsynoptic scale adjustments associated with the upper level jet streak's forcing of lee side cyclogenesis could be an important factor in the development of LLJ's in the Great Plains.

  7. Diverging Interpretations of Charlotte Brontë’s Jane Eyre (1847: Franco Zeffirelli’s and Robert Stevenson’s Screen Adaptations Divergences interprétatives autour de Jane Eyre (1847 de Charlotte Brontë : les adaptations cinématographiques de Franco Zeffirelli et Robert Stevenson

    Directory of Open Access Journals (Sweden)

    Delphine Letort

    2009-07-01

    Full Text Available Franco Zeffirelli et Robert Stevenson nous offrent deux interprétations de Jane Eyre à travers des adaptations qui retiennent des choix narratifs souvent parallèles mais dont les mises en scène diffèrent, creusant un écart manifeste au niveau de la caractérisation du personnage éponyme. Le premier dramatise le récit pour souligner l’obstination de l’enfant et retracer le développement de la jeune femme tandis que le second adopte une approche hollywoodienne classique, utilisant le noir et blanc pour évoquer la fragilité de l’enfant et de la femme dans une structure sociale répressive soumise à l’autorité masculine. Les portraits esquissés par les réalisateurs reflètent des choix d’interprétation guidés par une lecture personnelle et contemporaine du récit de Charlotte Brontë.

  8. Book Review: Drexl, J., Lee, N. (2013). Pharmaceutical Innovation, Competition and Patent Law : A Trilateral Perspective. Edward Elgar Publishing

    DEFF Research Database (Denmark)

    Minssen, Timo

    2014-01-01

    aspects of “Pharmaceutical Innovation, Competition and Patent Law”. It provides valuable analyses of the fundamental challenges that the pharmaceutical sector encounters on both a global and regional level. The editors and authors have thus compiled an important publication that will provide stimulation......This is a review of the recent publication “Pharmaceutical Innovation, Competition and Patent Law – A Trilateral Perspective”, edited by Max Planck Director Josef Drexl and Finnish scholar Nari Lee (Edward Elgar 2013, 322 p., ISBN 978 0 85793 245 7). In summary, I conclude that the editors, who...... of recent developments that have such a substantial impact on a significant area of law and practice. But are there any flaws? Considering the numerous useful case law citations, as well as the wide scope of the book, it is a little unfortunate that the book does not contain a table of cases...

  9. Mass elevation and lee effects markedly lift the elevational distribution of ground beetles in the Himalaya-Tibet orogen.

    Science.gov (United States)

    Schmidt, Joachim; Böhner, Jürgen; Brandl, Roland; Opgenoorth, Lars

    2017-01-01

    Mass elevation and lee effects markedly influence snow lines and tree lines in high mountain systems. However, their impact on other phenomena or groups of organisms has not yet been quantified. Here we quantitatively studied their influence in the Himalaya-Tibet orogen on the distribution of ground beetles as model organisms, specifically whether the ground beetle distribution increases from the outer to the inner parts of the orogen, against latitudinal effects. We also tested whether July temperature and solar radiation are predictors of the beetle's elevational distribution ranges. Finally, we discussed the general importance of these effects for the distributional and evolutionary history of the biota of High Asia. We modelled spatially explicit estimates of variables characterizing temperature and solar radiation and correlated the variables with the respective lower elevational range of 118 species of ground beetles from 76 high-alpine locations. Both July temperature and solar radiation significantly positively correlated with the elevational ranges of high-alpine beetles. Against the latitudinal trend, the median elevation of the respective species distributions increased by 800 m from the Himalayan south face north to the Transhimalaya. Our results indicate that an increase in seasonal temperature due to mass elevation and lee effects substantially impact the regional distribution patterns of alpine ground beetles of the Himalaya-Tibet orogen and are likely to affect also other soil biota there and in mountain ranges worldwide. Since these effects must have changed during orogenesis, their potential impact must be considered when biogeographic scenarios based on geological models are derived. As this has not been the practice, we believe that large biases likely exist in many paleoecological and evolutionary studies dealing with the biota from the Himalaya-Tibet orogen and mountain ranges worldwide.

  10. W3C director Tim Berners-Lee to be Knighted by Queen Elizabeth web inventor recognized for contributions to internet development

    CERN Document Server

    2003-01-01

    "Tim Berners-Lee, the inventor of the World Wide Web and director of the World Wide Web Consortium (W3C), will be made a Knight Commander, Order of the British Empire (KBE) by Queen Elizabeth" (1/2 page).

  11. The NAG Sensor NagC Regulates LEE Gene Expression and Contributes to Gut Colonization by Escherichia coli O157:H7

    Directory of Open Access Journals (Sweden)

    Josée Harel

    2017-04-01

    Full Text Available Enterohemorrhagic Escherichia coli (EHEC O157:H7 are human pathogens responsible for bloody diarrhea and renal failures. EHEC employ a type 3 secretion system to attach directly to the human colonic epithelium. This structure is encoded by the locus of enterocyte effacement (LEE whose expression is regulated in response to specific nutrients. In this study, we show that the mucin-derived sugars N-acetylglucosamine (NAG and N-acetylneuraminic acid (NANA inhibit EHEC adhesion to epithelial cells through down-regulation of LEE expression. The effect of NAG and NANA is dependent on NagC, a transcriptional repressor of the NAG catabolism in E. coli. We show that NagC is an activator of the LEE1 operon and a critical regulator for the colonization of mice intestine by EHEC. Finally, we demonstrate that NAG and NANA as well as the metabolic activity of Bacteroides thetaiotaomicron affect the in vivo fitness of EHEC in a NagC-dependent manner. This study highlights the role of NagC in coordinating metabolism and LEE expression in EHEC and in promoting EHEC colonization in vivo.

  12. The Effects of Input Enhancement on Grammar Learning and Comprehension: A Modified Replication of Lee (2007) with Eye-Movement Data

    Science.gov (United States)

    Winke, Paula M.

    2013-01-01

    In his 2007 study "Effects of Textual Enhancement and Topic Familiarity on Korean EFL Students' Reading Comprehension and Learning of Passive Form," Lee demonstrated that learners were better able to correct written sentences that contained incorrect English passive forms after exposure to texts flooded with enhanced (versus…

  13. Dick and Jane in 1989.

    Science.gov (United States)

    Purcell, Piper; Stewart, Lara

    1990-01-01

    A study of 62 children's readers in use in three Texas cities demonstrated that such books are less male-focused than they appeared to be in a similar 1972 survey. Contends that both boys and girls would benefit from a still more equitable representation. (DM)

  14. Haiglate tegevuse hindamine / Jane Alop

    Index Scriptorium Estoniae

    Alop, Jane

    2005-01-01

    Maailma Terviseorganisatsiooni Euroopa piirkonna büroo poolt välja töötatud haiglate tegevuse hindamise metoodikast PATH (Performance Assessment Tool for quality improvement in Hospitals) ning selle rakendamisest Eestis. Joonis: PATH kontseptuaalne mudel

  15. Attaching and effacing (A/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors.

    Science.gov (United States)

    Cepeda-Molero, Massiel; Berger, Cedric N; Walsham, Alistair D S; Ellis, Samuel J; Wemyss-Holden, Simon; Schüller, Stephanie; Frankel, Gad; Fernández, Luis Ángel

    2017-10-01

    Enteropathogenic E. coli (EPEC) is a human pathogen that causes acute and chronic pediatric diarrhea. The hallmark of EPEC infection is the formation of attaching and effacing (A/E) lesions in the intestinal epithelium. Formation of A/E lesions is mediated by genes located on the pathogenicity island locus of enterocyte effacement (LEE), which encode the adhesin intimin, a type III secretion system (T3SS) and six effectors, including the essential translocated intimin receptor (Tir). Seventeen additional effectors are encoded by genes located outside the LEE, in insertion elements and prophages. Here, using a stepwise approach, we generated an EPEC mutant lacking the entire effector genes (EPEC0) and intermediate mutants. We show that EPEC0 contains a functional T3SS. An EPEC mutant expressing intimin but lacking all the LEE effectors but Tir (EPEC1) was able to trigger robust actin polymerization in HeLa cells and mucin-producing intestinal LS174T cells. However, EPEC1 was unable to form A/E lesions on human intestinal in vitro organ cultures (IVOC). Screening the intermediate mutants for genes involved in A/E lesion formation on IVOC revealed that strains lacking non-LEE effector/s have a marginal ability to form A/E lesions. Furthermore, we found that Efa1/LifA proteins are important for A/E lesion formation efficiency in EPEC strains lacking multiple effectors. Taken together, these results demonstrate the intricate relationships between T3SS effectors and the essential role non-LEE effectors play in A/E lesion formation on mucosal surfaces.

  16. Attaching and effacing (A/E lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors.

    Directory of Open Access Journals (Sweden)

    Massiel Cepeda-Molero

    2017-10-01

    Full Text Available Enteropathogenic E. coli (EPEC is a human pathogen that causes acute and chronic pediatric diarrhea. The hallmark of EPEC infection is the formation of attaching and effacing (A/E lesions in the intestinal epithelium. Formation of A/E lesions is mediated by genes located on the pathogenicity island locus of enterocyte effacement (LEE, which encode the adhesin intimin, a type III secretion system (T3SS and six effectors, including the essential translocated intimin receptor (Tir. Seventeen additional effectors are encoded by genes located outside the LEE, in insertion elements and prophages. Here, using a stepwise approach, we generated an EPEC mutant lacking the entire effector genes (EPEC0 and intermediate mutants. We show that EPEC0 contains a functional T3SS. An EPEC mutant expressing intimin but lacking all the LEE effectors but Tir (EPEC1 was able to trigger robust actin polymerization in HeLa cells and mucin-producing intestinal LS174T cells. However, EPEC1 was unable to form A/E lesions on human intestinal in vitro organ cultures (IVOC. Screening the intermediate mutants for genes involved in A/E lesion formation on IVOC revealed that strains lacking non-LEE effector/s have a marginal ability to form A/E lesions. Furthermore, we found that Efa1/LifA proteins are important for A/E lesion formation efficiency in EPEC strains lacking multiple effectors. Taken together, these results demonstrate the intricate relationships between T3SS effectors and the essential role non-LEE effectors play in A/E lesion formation on mucosal surfaces.

  17. The Effect of Selected Cleaning Techniques on Berkshire Lee Marble: A Scientific Study at Philadelphia City Hall

    Science.gov (United States)

    Mossotti, Victor G.; Eldeeb, A. Raouf; Fries, Terry L.; Coombs, Mary Jane; Naude, Virginia N.; Soderberg, Lisa; Wheeler, George S.

    2002-01-01

    This report describes a scientific investigation of the effects of eight different cleaning techniques on the Berkshire Lee marble component of the facade of the East Center Pavilion at Philadelphia City Hall; the study was commissioned by the city of Philadelphia. The eight cleaning techniques evaluated in this study were power wash (proprietary gel detergent followed by water rinse under pressure), misting (treatment with potable, nebulized water for 24-36 hours), gommage (proprietary Thomann-Hanry low-pressure, air-driven, small-particle, dry abrasion), combination (gommage followed by misting), Armax (sodium bicarbonate delivered under pressure in a water wash), JOS (dolomite powder delivered in a low-pressure, rotary-vortex water wash), laser (thermal ablation), and dry ice (powdered-dry-ice abrasion delivered under pressure). In our study approximately 160 cores were removed from the building for laboratory analysis. We developed a computer program to analyze scanning-electron-micrograph images for the microscale surface roughness and other morphologic parameters of the stone surface, including the near-surface fracture density of the stone. An analysis of more than 1,100 samples cut from the cores provided a statistical basis for crafting the essential elements of a reduced-form, mixed-kinetics conceptual model that represents the deterioration of calcareous stone in terms of self-organized soiling and erosion patterns. This model, in turn, provided a basis for identifying the variables that are affected by the cleaning techniques and for evaluating the extent to which such variables influence the stability of the stone. The model recognizes three classes of variables that may influence the soiling load on the stone, including such exogenous environmental variables as airborne moisture, pollutant concentrations, and local aerodynamics, and such endogenous stone variables as surface chemistry and microstructure (fracturing, roughness, and so on). This study

  18. Oligotyping reveals stronger relationship of organic soil bacterial community structure with N-amendments and soil chemistry in comparison to that of mineral soil at Harvard Forest, MA, USA

    Science.gov (United States)

    Swathi A. Turlapati; Rakesh Minocha; Stephanie Long; Jordan Ramsdell; Subhash C. Minocha

    2015-01-01

    The impact of chronic nitrogen amendments on bacterial communities was evaluated at Harvard Forest, Petersham, MA, USA. Thirty soil samples (3 treatments × 2 soil horizons × 5 subplots) were collected in 2009 from untreated (control), low nitrogen-amended (LN; 50 kg NH4NO3ha-1yr

  19. Social networks and inference about unknown events: A case of the match between Google's AlphaGo and Sedol Lee.

    Directory of Open Access Journals (Sweden)

    Jonghoon Bae

    Full Text Available This study examines whether the way that a person makes inferences about unknown events is associated with his or her social relations, more precisely, those characterized by ego network density that reflects the structure of a person's immediate social relation. From the analysis of individual predictions over the Go match between AlphaGo and Sedol Lee in March 2016 in Seoul, Korea, this study shows that the low-density group scored higher than the high-density group in the accuracy of the prediction over a future state of a social event, i.e., the outcome of the first game. We corroborated this finding with three replication tests that asked the participants to predict the following: film awards, President Park's impeachment in Korea, and the counterfactual assessment of the US presidential election. Taken together, this study suggests that network density is negatively associated with vision advantage, i.e., the ability to discover and forecast an unknown aspect of a social event.

  20. Lee Sang Gak Telescope (LSGT): A Remotely Operated Robotic Telescope for Education and Research at Seoul National University

    Science.gov (United States)

    Im, Myungshin; Choi, Changsu; Kim, Kihyun

    2015-08-01

    We introduce the Lee Sang Gak Telescope (LSGT), a remotely operated, robotic 0.43-meter telescope. The telescope was installed at the Siding Spring Observatory, Australia, in 2014 October, to secure regular and exclusive access to the dark sky and excellent atmospheric conditions in the southern hemisphere from the Seoul National University (SNU) campus. Here, we describe the LSGT system and its performance, present example images from early observations, and discuss a future plan to upgrade the system. The use of the telescope includes (i) long-term monitoring observations of nearby galaxies, active galactic nuclei, and supernovae; (ii) rapid follow-up observations of transients such as gamma-ray bursts and gravitational wave sources; and (iii) observations for educational activities at SNU. Based on observations performed so far, we find that the telescope is capable of providing images to a depth of R=21.5 mag (point source detection) at 5-σ with 15 min total integration time under good obs-erving conditions.

  1. Economic value of angling on the Colorado River at Lees Ferry: Using secondary data to estimate the influence of seasonality

    Science.gov (United States)

    Bair, Lucas S.; Rogowski, David L.; Neher, Christopher

    2016-01-01

    Glen Canyon Dam (GCD) on the Colorado River in northern Arizona provides water storage, flood control, and power system benefits to approximately 40 million people who rely on water and energy resources in the Colorado River basin. Downstream resources (e.g., angling, whitewater floating) in Glen Canyon National Recreation Area (GCNRA) and Grand Canyon National Park are impacted by the operation of GCD. The GCD Adaptive Management Program was established in 1997 to monitor and research the effects of dam operations on the downstream environment. We utilized secondary survey data and an individual observation travel cost model to estimate the net economic benefit of angling in GCNRA for each season and each type of angler. As expected, the demand for angling decreased with increasing travel cost; the annual value of angling at Lees Ferry totaled US$2.7 million at 2014 visitation levels. Demand for angling was also affected by season, with per-trip values of $210 in the summer, $237 in the spring, $261 in the fall, and $399 in the winter. This information provides insight into the ways in which anglers are potentially impacted by seasonal GCD operations and adaptive management experiments aimed at improving downstream resource conditions.

  2. The contributions of Donald Lee Johnson to understanding the Quaternary geologic and biogeographic history of the California Channel Islands

    Science.gov (United States)

    Muhs, Daniel R.

    2013-01-01

    Over a span of 50 years, native Californian Donald Lee Johnson made a number of memorable contributions to our understanding of the California Channel Islands. Among these are (1) recognizing that carbonate dunes, often cemented into eolianite and derived from offshore shelf sediments during lowered sea level, are markers of glacial periods on the Channel Islands; (2) identifying beach rock on the Channel Islands as the northernmost occurrence of this feature on the Pacific Coast of North America; (3) recognizing of the role of human activities in historic landscape modification; (4) identifying both the biogenic and pedogenic origins of caliche “ghost forests” and laminar calcrete forms on the Channel Islands; (5) providing the first soil maps of several of the islands, showing diverse pathways of pedogenesis; (6) pointing out the importance of fire in Quaternary landscape history on the Channel Islands, based on detailed stratigraphic studies; and (7), perhaps his greatest contribution, clarifying the origin of Pleistocene pygmy mammoths on the Channel Islands, due not to imagined ancient land bridges, but rather the superb swimming abilities of proboscideans combined with lowered sea level, favorable paleowinds, and an attractive paleovegetation on the Channel Islands. Don was a classic natural historian in the great tradition of Charles Darwin and George Gaylord Simpson, his role models. Don’s work will remain important and useful for many years and is an inspiration to those researching the California Channel Islands today.

  3. Comparison of total polyphenols content and antioxidant potential of wines from ‘Welschriesling’ and ‘Sauvignon Blanc’ varieties during ageing on fine lees

    Directory of Open Access Journals (Sweden)

    Jasna Lužar

    2016-10-01

    Full Text Available Phenolic compounds are key components of wine, since they contribute to wine characteristics such as colour, astringency and bitterness. They also act like antioxidants, with mechanisms involving free-radical scavenging that could prevent cardiovascular diseases and cancer. The aim of the present work was to compare the obtained results of total polyphenols content and antioxidant potential (AOP of several white wines (welschriesling and sauvignon blanc during ageing on fine lees. The total polyphenols content decreased in average for 16.1 % in welschriesling wines and for 18.7 % in sauvignon blanc wines in the period of three months of wine ageing on lees. In the same period AOP of wines decreased in average for 16.0 % in welschriesling wines and for 8.0 % in sauvignon blanc wines. Expectedly, the samples with added oak chips in grape must had higher antioxidant potential than others.

  4. Modelagem conjunta da média e dispersão de Nelder e Lee como alternativa aos métodos de Taguchi

    Directory of Open Access Journals (Sweden)

    Edmilson Rodrigues Pinto

    2006-08-01

    Full Text Available Nos últimos anos, uma coleção de técnicas para a melhoria da qualidade foi desenvolvida, no Japão, por Genichi Taguchi no planejamento, na evolução e na fabricação de produtos industrializados. Esta revolução no campo da qualidade despertou o interesse, no mundo inteiro, de vários engenheiros e estatísticos, que propuseram vários métodos alternativos, mais claros e eficientes do que aqueles propostos por Taguchi. Nelder e Lee observaram que a metodologia de Taguchi conduz a um modelo conjunto para a média e dispersão, usando modelos lineares generalizados. Eles mostraram como esta classe é geral e suficiente para a análise desses modelos. O objetivo deste artigo é fazer uma síntese da modelagem conjunta da média e dispersão, proposta por Nelder e Lee, explicitando, de uma forma concisa, os principais pontos da teoria.In the last years, in Japan, Genichi Taguchi developed some techniques to improve the quality of the products during its design, evolution and manufacture. His ideas have raised the attention of engineers and statisticians around the world who have proposed some alternative methods that are simpler and more efficient than Taguchi's methods. Nelder and Lee observed that Taguchi's methodology lead up to a joint model for the mean and dispersion employing generalized linear models. They showed that this class is general and sufficient to analyze Taguchi's Models. The purpose of this work is to describe joint modeling of mean and dispersion that was proposed by Nelder and Lee and the key points of the theory in a concise manner.

  5. Inferring long-term carbon sequestration from tree rings at Harvard Forest: A calibration approach using tree ring widths and geochemistry / flux tower data

    Science.gov (United States)

    Belmecheri, S.; Maxwell, S.; Davis, K. J.; Alan, T. H.

    2012-12-01

    Improving the prediction skill of terrestrial carbon cycle models is important for reducing the uncertainties in global carbon cycle and climate projections. Additional evaluation and calibration of carbon models is required, using both observations and long-term proxy-derived data. Centennial-length data could be obtained from tree-rings archives that provide long continuous series of past forest growth changes with accurate annual resolution. Here we present results from a study conducted at Harvard Forest (Petersham, Massachusetts). The study examines the potential relationship between δ13C in dominant trees and GPP and/or NEE measured by the Harvard Forest flux tower (1992-2010). We have analyzed the δ13C composition of late wood-cellulose over the last 18 years from eastern hemlock (Tsuga canadensis) and northern red oak (Quercus rubra) trees growing in the flux tower footprint. δ13C values, corrected for the declining trend of atmospheric δ13C, show a decreasing trend from 1992 to 2010 and therefore a significant increase in discrimination (Δ). The intra-cellular CO2 (Ci) calculated from Δ shows a significant increase for both tree species and follows the same rate of atmospheric CO2 (Ca) increase (Ci/Ca increases). Interestingly, the net Ci and Δ increase observed for both species did not result in an increase of the iWUE. Ci/Ca is strongly related to the growing season Palmer Drought Severity Index (PDSI) for both species thus indicating a significant relationship between soil moisture conditions and stomatal conductance. The Ci trend is interpreted as a result of higher CO2 assimilation in response to increasing soil moisture allowing a longer stomata opening and therefore stimulating tree growth. This interpretation is consistent with the observed increase in GPP and the strengthening of the carbon sink (more negative NEE). Additionally, the decadal trends of basal area increment (BAI) calculated from tree-ring widths exhibit a positive trend over

  6. A Rasch Analysis of Assessments of Morning and Evening Fatigue in Oncology Patients Using the Lee Fatigue Scale.

    Science.gov (United States)

    Lerdal, Anners; Kottorp, Anders; Gay, Caryl; Aouizerat, Bradley E; Lee, Kathryn A; Miaskowski, Christine

    2016-06-01

    To accurately investigate diurnal variations in fatigue, a measure needs to be psychometrically sound and demonstrate stable item function in relationship to time of day. Rasch analysis is a modern psychometric approach that can be used to evaluate these characteristics. To evaluate, using Rasch analysis, the psychometric properties of the Lee Fatigue Scale (LFS) in a sample of oncology patients. The sample comprised 587 patients (mean age 57.3 ± 11.9 years, 80% women) undergoing chemotherapy for breast, gastrointestinal, gynecological, or lung cancer. Patients completed the 13-item LFS within 30 minutes of awakening (i.e., morning fatigue) and before going to bed (i.e., evening fatigue). Rasch analysis was used to assess validity and reliability. In initial analyses of differential item function, eight of the 13 items functioned differently depending on whether the LFS was completed in the morning or in the evening. Subsequent analyses were conducted separately for the morning and evening fatigue assessments. Nine of the morning fatigue items and 10 of the evening fatigue items demonstrated acceptable goodness-of-fit to the Rasch model. Principal components analyses indicated that both morning and evening assessments demonstrated unidimensionality. Person-separation indices indicated that both morning and evening fatigue scales were able to distinguish four distinct strata of fatigue severity. Excluding four items from the morning fatigue scale and three items from the evening fatigue scale improved the psychometric properties of the LFS for assessing diurnal variations in fatigue severity in oncology patients. Copyright © 2016 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  7. Transcriptome analysis of stem development in the tumourous stem mustard Brassica juncea var. tumida Tsen et Lee by RNA sequencing

    Directory of Open Access Journals (Sweden)

    Sun Quan

    2012-04-01

    Full Text Available Abstract Background Tumourous stem mustard (Brassica juncea var. tumida Tsen et Lee is an economically and nutritionally important vegetable crop of the Cruciferae family that also provides the raw material for Fuling mustard. The genetics breeding, physiology, biochemistry and classification of mustards have been extensively studied, but little information is available on tumourous stem mustard at the molecular level. To gain greater insight into the molecular mechanisms underlying stem swelling in this vegetable and to provide additional information for molecular research and breeding, we sequenced the transcriptome of tumourous stem mustard at various stem developmental stages and compared it with that of a mutant variety lacking swollen stems. Results Using Illumina short-read technology with a tag-based digital gene expression (DGE system, we performed de novo transcriptome assembly and gene expression analysis. In our analysis, we assembled genetic information for tumourous stem mustard at various stem developmental stages. In addition, we constructed five DGE libraries, which covered the strains Yong'an and Dayejie at various development stages. Illumina sequencing identified 146,265 unigenes, including 11,245 clusters and 135,020 singletons. The unigenes were subjected to a BLAST search and annotated using the GO and KO databases. We also compared the gene expression profiles of three swollen stem samples with those of two non-swollen stem samples. A total of 1,042 genes with significantly different expression levels occurring simultaneously in the six comparison groups were screened out. Finally, the altered expression levels of a number of randomly selected genes were confirmed by quantitative real-time PCR. Conclusions Our data provide comprehensive gene expression information at the transcriptional level and the first insight into the understanding of the molecular mechanisms and regulatory pathways of stem swelling and development

  8. Staarkleidid / Lee Hanael

    Index Scriptorium Estoniae

    Hanael, Lee

    2008-01-01

    10 maailma kuulsamat kleiti kuulusid Marilyn Monroele, Audrey Hepburnile, printsess Dianale, Vivien Leighle, Tina Turnerile, Julia Robertsile, Liz Hurleyle, Sarah Jessica Parkerile, Keira Knightleyle, Jacqueline Kennedyle

  9. HYDROLOGY, LEE COUNTY, TEXAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a Flood Insurance...

  10. HYDRAULICS, LEE COUNTY, MISSISSIPPI

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  11. HYDROLOGY, LEE COUNTY, MISSISSIPPI

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  12. Erasmusega Eestisse / Merike Lees

    Index Scriptorium Estoniae

    Lees, Merike, 1976-

    2014-01-01

    Prantsuse noormees Théo Brunie õppis Lumière’i ülikoolis Lyonis kommunikatsiooni. Aasta Erasmuse vahetusüliõpilasena Balti Filmi- ja Meediakoolis kasutas ta võimalust õppida kommunikatsiooni koos filmitegemisega

  13. Lee Nnukwu Ukochukwu

    African Journals Online (AJOL)

    User

    Another form of it has more verses sung in the exact fashion as the first. Kpakpando na-amuke and Nni ndi ... A general trend of harmonizing only the chorus or refrain is observed. Only a few works have harmonized .... Something that looks like a second development begins in bar nine. It is a descending move from the ...

  14. On the Accuracy of In Situ Water Vapor Measurements in the Troposphere and Lower Stratosphere with the Harvard Lyman-Alpha Hygrometer

    Science.gov (United States)

    Hintsa, Eric J.; Weinstock, Elliot M.; Anderson, James G.; May, Randy D.; Hurst, Dale F.

    1999-01-01

    In an effort to better constrain atmospheric water vapor mixing ratios and to understand the discrepancies between different measurements of water vapor in the stratosphere and troposphere, we have carefully examined data from the Harvard Lyman-alpha photofragment fluorescence hygrometer, which has flown on the NASA ER-2 aircraft from 1992 through 1998. The instrument is calibrated in the laboratory before and after each deployment, and the calibration is checked by direct absorption measurements in the troposphere. On certain flights, the ER-2 flew level tracks during which water vapor varied by up to 80 ppmv, under nearly constant atmospheric conditions. These flights provide a stringent test of our calibration via direct absorption and indicate agreement to within 3%. During the 1997 Photochemistry of Ozone Loss in the Arctic Region In Summer (POLARIS) mission, our Lyman-alpha instrument was compared with a new diode laser hygrometer from the Jet Propulsion Laboratory. Overall agreement was 5% during the June/July deployment and 1% for potential temperatures of 490 to 540 K. The accuracy of our instrument is shown to be +/-5 %, with an additional offset of at most 0.1 ppmv. Data from this instrument, combined with simultaneous measurements of CH4, and H2, are therefore ideal for studies of the hydrogen budget of the lower stratosphere.

  15. DigitSeis: A New Digitization Software and its Application to the Harvard-Adam Dziewoński Observatory Collection

    Science.gov (United States)

    Bogiatzis, P.; Altoé, I. L.; Karamitrou, A.; Ishii, M.; Ishii, H.

    2015-12-01

    DigitSeis is a new open-source, interactive digitization software written in MATLAB that converts digital, raster images of analog seismograms to readily usable, discretized time series using image processing algorithms. DigitSeis automatically identifies and corrects for various geometrical distortions of seismogram images that are acquired through the original recording, storage, and scanning procedures. With human supervision, the software further identifies and classifies important features such as time marks and notes, corrects time-mark offsets from the main trace, and digitizes the combined trace with an analysis to obtain as accurate timing as possible. Although a large effort has been made to minimize the human input, DigitSeis provides interactive tools for challenging situations such as trace crossings and stains in the paper. The effectiveness of the software is demonstrated with the digitization of seismograms that are over half a century old from the Harvard-Adam Dziewoński observatory that is still in operation as a part of the Global Seismographic Network (station code HRV and network code IU). The spectral analysis of the digitized time series shows no spurious features that may be related to the occurrence of minute and hour marks. They also display signals associated with significant earthquakes, and a comparison of the spectrograms with modern recordings reveals similarities in the background noise.

  16. The Power of Exercise and the Exercise of Power: The Harvard Fatigue Laboratory, Distance Running, and the Disappearance of Work, 1919-1947.

    Science.gov (United States)

    Scheffler, Robin Wolfe

    2015-08-01

    In the early twentieth century, fatigue research marked an area of conflicting scientific, industrial, and cultural understandings of working bodies. These different understandings of the working body marked a key site of political conflict during the growth of industrial capitalism. Many fatigue researchers understood fatigue to be a physiological fact and allied themselves with Progressive-era reformers in urging industrial regulation. Opposed to these researchers were advocates of Taylorism and scientific management, who held that fatigue was a mental event and that productivity could be perpetually increased through managerial efficiency. Histories of this conflict typically cease with the end of the First World War, when it is assumed that industrial fatigue research withered away. This article extends the history of fatigue research through examining the activities of the Harvard Fatigue Laboratory in the 1920s and 1930s. The Laboratory developed sophisticated biochemical techniques to study the blood of exercising individuals. In particular, it found that exercising individuals could attain a biochemically "steady state," or equilibrium, and extrapolated from this to assert that fatigue was psychological, not physiological, in nature. In contrast to Progressive-era research, the Laboratory reached this conclusion through laboratory examination, not of industrial workers, but of Laboratory staff members and champion marathon runners. The translation of laboratory research to industrial settings, and the eventual erasure of physiological fatigue from discussions of labor, was a complex function of institutional settings, scientific innovation, and the cultural meanings of work and sport.

  17. A study of the importance of education and cost incentives on individual food choices at the Harvard School of Public Health cafeteria.

    Science.gov (United States)

    Michels, Karin B; Bloom, Barry R; Riccardi, Paul; Rosner, Bernard A; Willett, Walter C

    2008-02-01

    To investigate the importance of cost and awareness of health- or disease-promoting properties of foods and meals for choices by customers of a cafeteria. A non-randomized intervention study. A medium size cafeteria in the Harvard School of Public Health. Customers of the cafeteria mainly consisting of public health students, faculty, and school staff and workers from the medical campus. The purchase of healthy foods and dishes was subsidized and their prices reduced by 20%. This promotion was accompanied by the distribution of educational material. Change in consumption of healthy and less healthy foods. The geometric mean was used to calculate the change in consumption. During the intervention, we observed a 6% increase in the consumption of healthy foods (95% confidence interval [CI]; 5% to 8%), and a 2% decline in the consumption of less-healthy foods (95% CI; -1% to -4%). After the prices returned to their original levels, the consumption of healthy foods increased further to 17% (95% CI; 13% to 20%) and a 2% decline in the consumption of less-healthy foods (95% CI; % 1 to -5%) persisted. Subsidizing healthful meals and educating consumers about the importance of a healthy diet can result in a modest increase in the selection of healthy foods and meals that can be maintained beyond the periods of subsidy and promotion.

  18. Numerical experiments on plasma focus for soft x-ray yield scaling laws derivation using Lee model

    International Nuclear Information System (INIS)

    Akel, M.

    2012-09-01

    The required plasma parameters of krypton and xenon at different temperatures were calculated, the x-ray emission properties of plasmas were studied, and based on the corona model the suitable temperature range for generating H-like and He-like ions (therefore soft x-ray emissions) of different gases plasma were found. The code is applied to characterize the plasma focus in different plasma focus devices, and for optimizing the nitrogen, oxygen, neon, argon, krypton and xenon soft x-ray yields based on bank, tubes and operating parameters. It is found that the soft x-ray yield increases with changing pressure until it reaches the maximum value for each plasma focus device. Keeping the bank parameters, operational voltage unchanged but systematically changing other parameters, numerical experiments were performed finding the optimum combination of P o , Z o and 'a' for the maximum soft x-ray yield. Thus we expect to increase the soft x-ray yield of plasma focus device several-fold from its present typical operation; without changing the capacitor bank, merely by changing the electrode configuration and the operating pressure. The Lee model code was also used to run numerical experiments on plasma focus devices for optimizing soft x-ray yield with reducing L o , varying L o and 'a' to get engineering designs with maximum soft x-ray yield for these devices at different experimental conditions and gases. Numerical experiments showed the influence of the gas used in plasma focus and its properties on soft x-ray emission and its properties and then on its applications. Scaling laws for soft x-ray of nitrogen, oxygen, neon, argon, krypton and xenon plasma focus, in terms of energy, peak discharge current and focus pinch current were found. Radiative cooling effects are studied indicating that radiative collapse may be observed for heavy noble gases (Ar, Kr, Xe) for pinch currents even below 100 kA. The results show that the line radiation emission and tube voltages have

  19. Genetic Structure Change in Harvard Vaccine Strain of Clostridium Tetani for the Period of 1990 to 2010 by Pulsed-Field Gel Electrophoresis

    Directory of Open Access Journals (Sweden)

    Ahmad Sakhravi

    2013-07-01

    Full Text Available Background: PFGE facilitates the differential migration of large DNA fragments through agarose gel by constantly changing the direction of the electrical field during electrophoresis. Possibility of high difference between strains and repeatability make PFGE one of the strong molecular methods in study of bacterial strains in epidemiology. To identifying and DNA fingerprinting of vaccine strain of Clostridium tetani by PFGE technique. Also, possibility of genotyping profile changes in frequency of vaccine strain of C. tetani during the period of 1990 to 2011.Materials and Methods: The vaccine strain of C. tetani was provided by Razi Vaccine and Serum Research Institute in Karaj. The seeds were inoculated into Columbia blood agar and grown for 72 h. The cultures were incubated at 35°C in anaerobic conditions. The PFGE analyses were performed using genomic DNA digested with the restriction enzyme SmaI. The electrophoresis analyses were carried out on a CHEF DR III apparatus (Bio-Rad and band patterns obtained were then analyzed.Results: The PFGE profile obtained from vaccine strain during a period of more than two decades revealed no remarkable genetic changes and mutations. This type of analysis provides detailed data useful for surveillance of vaccine strains and isolates as well as for the selection of certain predominant profiles for further investigation.Conclusion: This study showed no considerable change in chromosomal genome of Harvard, the vaccine strain. It is therefore concluded that the vaccine produced by Razi Institute had evidently no alteration or modification in accordance to PFGE profile analysis during a period of more than two decades.

  20. EVALUACIÓN DE UN MEDIO ALTERNATIVO PARA LA PRODUCCIÓN DE TOXINA TETÁNICA POR Clostridium tetani CEPA HARVARD

    Directory of Open Access Journals (Sweden)

    Arias Janeth

    2005-06-01

    Full Text Available Se evaluó un medio alternativo, buscando mejorar la producción de vacuna antitetánica utilizando Cl. tetani cepa Harvard a fin de conocer el comportamiento de éste frente a nuevos sustratos. El trabajo se dividió en dos fases, en la primera se evaluaron tres variables (glucosa, extracto de soya y sulfato ferroso cada una con tres niveles (bajo, intermedio y alto, para la producción de la toxina tetánica. Por medio de un análisis estadístico se escogieron los ensayos más relevantes (Ensayos 5, 6, 7 para la segunda fase; teniendo en cuenta que éstos produjeron la mayor cantidad de toxina en el menor tiempo. En la segunda fase se realizaron tres fermentaciones de 5 L por duplicado utilizando el medio GIA01. Los parámetros medidos en cada muestra fueron: biomasa, pH, glucosa y producción de toxina; a la última muestra de cada fermentación se le determinó la dosis mínima letal. A partir de los resultados obtenidos se concluyó que el comportamiento de Cl. tetani en medio GIA01 es muy similar al reportado en el medio tradicional en cuanto a la producción de toxina y la cinética de crecimiento del microorganismo, sin embargo con el medio GIA01 se produce mayor cantidad de biomasa lo cual no es deseable para una producción a gran escala.

  1. Assessing the factorial structure and measurement invariance of PTSD by gender and ethnic groups in Sri Lanka: An analysis of the modified Harvard Trauma Questionnaire (HTQ).

    Science.gov (United States)

    Tay, Alvin Kuowei; Jayasuriya, Rohan; Jayasuriya, Dinuk; Silove, Derrick

    2017-04-01

    The Harvard Trauma Questionnaire (HTQ) remains the most widely used screening measure for post-traumatic stress disorder (PTSD) in the refugee and post-conflict field. The present study is the first to test the factorial structure and measurement invariance of the HTQ according to DSM-5 criteria across gender and ethnic groups in the ethnically diverse society of post-conflict Sri Lanka. The survey sample included 5136 participants (86% response rate) followed up 12 months after a baseline nationally representative survey undertaken in Sri Lanka in 2014. Exposure to conflict-related traumatic experiences (TEs) generating a trauma count (TC), and symptoms of PTSD were assessed using a modified version of the HTQ adapted to the local context. The final analytic sample included 4260 participants after excluding records with missing data on key variables. We conducted Multigroup Confirmatory Factor Analysis (MG-CFA) to test the four-factor (DSM-5 consistent) and three-factor (DSM-IV-TR) models of PTSD, then assessing measurement invariance of the four factor model by gender and ethnic groups. The three-factor and four-factor DSM-5 model each produced a good fit across the sample as a whole. In addition, there was configural, metric, and scalar invariance for the four-factor model both by gender and ethnicity. The trauma count was directly associated with each of the symptom domains of the four factor model. Our findings provide support for the capacity of the modified HTQ to measure the DSM5 construct of PTSD across gender and key ethnic groupings in Sri Lanka. Confirmation of our findings in other cultures will be important. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Combined proton and photon irradiation for craniopharyngioma: Long-term results of the early cohort of patients treated at Harvard Cyclotron Laboratory and Massachusetts General Hospital

    International Nuclear Information System (INIS)

    Fitzek, Markus M.; Linggood, Rita M.; Adams, Judy; Munzenrider, John E.

    2006-01-01

    Purpose: We report the results of the early cohort of patients treated for craniopharyngioma with combined proton-photon irradiation at the Massachusetts General Hospital and the Harvard Cyclotron Laboratory. Methods and Materials: Between 1981 and 1988, 15 patients with craniopharyngioma were treated in part or entirely with fractionated 160 MeV proton beam therapy. The group consisted of 5 children (median age, 15.9 years) and 10 adults (median age, 36.2 years). Median dose prescribed to the tumor was 56.9 cobalt Gray equivalent (CGE; 1 proton Gray = 1.1 CGE). The median proton component was 26.9 CGE. Patients were treated after documented recurrence after initial surgery (n = 6) or after subtotal resection or biopsy (n = 9). None had had prior radiation therapy. Results: Median observation period of surviving patients (n = 11) was 13.1 years from radiotherapy. One patient was lost to follow-up with tumor control after 5.2 years. Actuarial 10-year survival rate was 72%. Four patients have died 5-9.1 years after treatment, two from local failure. Actuarial 5- and 10-year local control rates were 93% and 85%, respectively. The functional status of the living adult patients is unaltered from their preradiotherapy status; all of them continued leading normal or near normal working lives. None of the patients treated as a child had experienced recurrence of tumor. One child shows learning difficulties and slight retardation, comparable to his preradiotherapy status. The others have professional achievements within the normal range. Conclusion: Results in terms of survival and local control are comparable with other contemporary series. Although no formal neuropsychological testing was performed, the surrogate measures of lifestyle and professional accomplishments appear to be satisfactory

  3. Modelling the impact of soil Carbonic Anhydrase on the net ecosystem exchange of OCS at Harvard forest using the MuSICA model

    Science.gov (United States)

    Launois, Thomas; Ogée, Jérôme; Commane, Roisin; Wehr, Rchard; Meredith, Laura; Munger, Bill; Nelson, David; Saleska, Scott; Wofsy, Steve; Zahniser, Mark; Wingate, Lisa

    2016-04-01

    The exchange of CO2 between the terrestrial biosphere and the atmosphere is driven by photosynthetic uptake and respiratory loss, two fluxes currently estimated with considerable uncertainty at large scales. Model predictions indicate that these biosphere fluxes will be modified in the future as CO2 concentrations and temperatures increase; however, it still unclear to what extent. To address this challenge there is a need for better constraints on land surface model parameterisations. Additional atmospheric tracers of large-scale CO2 fluxes have been identified as potential candidates for this task. In particular carbonyl sulphide (OCS) has been proposed as a complementary tracer of gross photosynthesis over land, since OCS uptake by plants is dominated by carbonic anhydrase (CA) activity, an enzyme abundant in leaves that catalyses CO2 hydration during photosynthesis. However, although the mass budget at the ecosystem is dominated by the flux of OCS into leaves, some OCS is also exchanged between the atmosphere and the soil and this component of the budget requires constraining. In this study, we adapted the process-based isotope-enabled model MuSICA (Multi-layer Simulator of the Interactions between a vegetation Canopy and the Atmosphere) to include the transport, reaction, diffusion and production of OCS within a forested ecosystem. This model was combined with 3 years (2011-2013) of in situ measurements of OCS atmospheric concentration profiles and fluxes at the Harvard Forest (Massachussets, USA) to test hypotheses on the mechanisms responsible for CA-driven uptake by leaves and soils as well as possible OCS emissions during litter decomposition. Model simulations over the three years captured well the impact of diurnally and seasonally varying environmental conditions on the net ecosystem OCS flux. A sensitivity analysis on soil CA activity and soil OCS emission rates was also performed to quantify their impact on the vertical profiles of OCS inside the

  4. Dreams of the Hmong Kingdom: The Quest for Legitimation in French Indochina, 1850- 1960, by Mai Na M. Lee. Madison, University of Wisconsin Press, 2015. 430 pages.

    Directory of Open Access Journals (Sweden)

    Nengher N. Vang

    2015-12-01

    Full Text Available This article provides a book review of Mai Na M. Lee’s Dreams of the Hmong Kingdom: The Quest for Legitimation in French Indochina, 1850-1960. Dreams of the Hmong Kingdom. It highlights the contribution of the book to the historiography of the Hmong and provides a critical assessment of the dichotomous analytical framework that Lee uses to analyze the rivalry between Hmong messianic leaders and Hmong political brokers and the competition between the Ly and Lo clans for paramountcy in French Indochina

  5. Lauren Berlant and Lee Edelman, Sex, Or The Unbearable (Durham: Duke University Press, 2014, pp. 168, ISBN: 9780822355946, £13.99, paperback.

    Directory of Open Access Journals (Sweden)

    Hannah Proctor

    2014-01-01

    Full Text Available 'So few colleges and universities bother to teach human sexuality...so much stigma adheres even to scholarly investigation of sex,' Gayle Rubin lamented in her 1984 essay 'Thinking Sex'. But it was an academic conference on Rubin's work - 'Rethinking Sex', a lavish threeday event, held at the University of Pennsylvania in 2009 - that provided the initial impetus for Lauren Berlant and Lee Edelman to enter into a dialogue on sexuality. The result is Sex, or the Unbearable, published by Duke University Press, the first in a series on queer theory edited by the authors.

  6. Representação sonora entre literatura e cinema: A questão do ponto de escuta nas adaptações de Persuasão de Jane Austen

    Directory of Open Access Journals (Sweden)

    Fernando Morais Da Costa

    2013-12-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2013n65p185   Explorar a representação sonora pela literatura e em adaptações de obras literárias para o cinema. Analisar a representação de ambientes sonoros, da relação dos personagens com tais ambientes e os processos de identificação entre espectador e personagem, especialmente pelas nuances possíveis do ponto de escuta. Entendemos neste artigo que analisar a identificação entre espectador e personagem através da construção do ponto de escuta é tratar de um procedimento narrativo pouco analisado tanto no campo dos estudos literários quanto na teoria cinematográfica. Para tanto, a análise das adaptações cinematográficas dos romances de Jane Austen terá papel central, embora haja no decorrer do texto exemplos outros.

  7. Topography and vegetation as predictors of snow water equivalent across the alpine treeline ecotone at Lee Ridge, Glacier National Park, Montana, U.S.A.

    Science.gov (United States)

    Geddes, C.A.; Brown, D.G.; Fagre, D.B.

    2005-01-01

    We derived and implemented two spatial models of May snow water equivalent (SWE) at Lee Ridge in Glacier National Park, Montana. We used the models to test the hypothesis that vegetation structure is a control on snow redistribution at the alpine treeline ecotone (ATE). The statistical models were derived using stepwise and "best" subsets regression techniques. The first model was derived from field measurements of SWE, topography, and vegetation taken at 27 sample points. The second model was derived using GIS-based measures of topography and vegetation. Both the field- (R² = 0.93) and GIS-based models (R² = 0.69) of May SWE included the following variables: site type (based on vegetation), elevation, maximum slope, and general slope aspect. Site type was identified as the most important predictor of SWE in both models, accounting for 74.0% and 29.5% of the variation, respectively. The GIS-based model was applied to create a predictive map of SWE across Lee Ridge, predicting little snow accumulation on the top of the ridge where vegetation is scarce. The GIS model failed in large depressions, including ephemeral stream channels. The models supported the hypothesis that upright vegetation has a positive effect on accumulation of SWE above and beyond the effects of topography. Vegetation, therefore, creates a positive feedback in which it modifies its, environment and could affect the ability of additional vegetation to become established.

  8. Samuel Holden Parsons Lee (1772-1863): American physician, entrepreneur and selfless fighter of the 1798 Yellow Fever epidemic of New London, Connecticut.

    Science.gov (United States)

    Mattie, James K; Desai, Sukumar P

    2015-02-01

    Samuel Holden Parsons Lee practised medicine at a time when the germ theory of disease had not yet been proposed and antibiotics remained undiscovered. In 1798 he served selflessly as the only physician in town who was willing to battle the Yellow Fever outbreak of New London, Connecticut. Because he practised at the dawn of the age of patent medicine, unfortunately his name also came to be associated with medical quackery. We argue that his contributions have been grossly underestimated. He compounded and vended medications - including bilious pills and bitters - that were gold standards of the day. Moreover, one preparation for treatment of kidney stones led to his sub-specialization in this field and was met with such success that its sale continued for nearly 100 years after his death. While a talented medical man, Lee also had a knack for business, finding success in trading, whaling and real estate. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  9. Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot): study protocol for a randomized controlled trial.

    Science.gov (United States)

    Sackley, Catherine M; Smith, Christina H; Rick, Caroline; Brady, Marian C; Ives, Natalie; Patel, Ramilla; Roberts, Helen; Dowling, Francis; Jowett, Sue; Wheatley, Keith; Patel, Smitaa; Kelly, Debbie; Sands, Gina; Clarke, Carl

    2014-06-07

    Parkinson's disease is a common movement disorder affecting approximately 127,000 people in the UK, with an estimated two thirds having speech-related problems. Currently there is no preferred approach to speech and language therapy within the NHS and there is little evidence for the effectiveness of standard NHS therapy or Lee Silverman voice treatment. This trial aims to investigate the feasibility and acceptability of randomizing people with Parkinson's disease-related speech or voice problems to Lee Silverman voice treatment or standard speech and language therapy compared to a no-intervention control. The PD COMM pilot is a three arm, assessor-blinded, randomized controlled trial. Randomization will be computer-generated with participants randomized at a ratio of 1:1:1. Participants randomized to intervention arms will be immediately referred to the appropriate speech and language therapist. The target population are patients with a confirmed diagnosis of idiopathic Parkinson's disease who have problems with their speech or voice. The Lee Silverman voice treatment intervention group will receive the standard regime of 16 sessions between 50 and 60 minutes in length over four weeks, with extra home practice. The standard speech and language therapy intervention group will receive a dose determined by patients' individual needs, but not exceeding eight weeks of treatment. The control group will receive standard care with no speech and language therapy input for at least six months post-randomization. Outcomes will be assessed at baseline (pre-randomization) and post- randomization at three, six, and 12 months. The outcome measures include patient-reported voice measures, quality of life, resource use, and assessor-rated speech recordings. The recruitment aim is at least 60 participants over 21 months from 11 sites, equating to at least 20 participants in each arm of the trial. This trial is ongoing and recruitment commenced in May 2012. This study will

  10. Reorientando a identidade nacional em Native speaker, de Chang-rae Lee, e O sol se põe em São Paulo, de Bernardo Carvalho

    Directory of Open Access Journals (Sweden)

    Rex P. Nielson

    2014-01-01

    Full Text Available A comparative reading of the novels Native speaker (1995, by the North American writer Chang-rae Lee, and O sol se põe em São Paulo (2007, by Bernardo Carvalho, allows for a reevaluation of how minority identities have been constructed in the two American megalopolises New York and São Paulo. The plotlines of both nove ls hinge on the identity crisis of a second-generation Asian immigrant (from Korea in one case and Japan in the other who is seeking to negotiate his American identity (speaking in hemispheric terms in terms of his family‟s origin and language. However, despite the similar anxieties over assimilation present in both novels, they both reveal significant differences regarding the ways in which the United States and Brazil have responded to cultural difference even as they challenge national myths of inclusi on and belonging.

  11. Samsung : Lee Byung Chull, créateur d’un modèle mondial (1938-1987)

    OpenAIRE

    Park-Barjot, Rang-Ri

    2012-01-01

    Samsung, la firme aux « trois étoiles », a été fondée en 1938 par Lee Byung Chull, un entrepreneur d’exception. D’abord connu pour ses produits bas de gamme et bon marché, le groupe s’est imposé à la pointe de la technologie grâce à un modèle industriel efficace. En dépit de sa diversification, Samsung est devenu l’un des leaders mondiaux de l’ère numérique. Samsung a réalisé une spectaculaire percée dans l’électrotechnique et l’électronique, à travers sa filiale Samsung Electronics, leader m...

  12. Enteropathogenic E. coli non-LEE encoded effectors NleH1 and NleH2 attenuate NF-κB activation.

    Science.gov (United States)

    Royan, Sandhya V; Jones, Rheinallt M; Koutsouris, Athanasia; Roxas, Jennifer L; Falzari, Kanakeshwari; Weflen, Andrew W; Kim, Amy; Bellmeyer, Amy; Turner, Jerrold R; Neish, Andrew S; Rhee, Ki-Jong; Viswanathan, V K; Hecht, Gail A

    2010-12-01

    Enteric bacterial pathogens have evolved sophisticated strategies to evade host immune defences. Some pathogens deliver anti-inflammatory effector molecules into the host cell cytoplasm via a type III secretion system (T3SS). Enteropathogenic Escherichia coli (EPEC) inhibits inflammation by an undefined, T3SS-dependent mechanism. Two proteins encoded outside of the EPEC locus of enterocyte effacement (LEE) pathogenicity island, non-LEE-encoded effector H1 (NleH1) and H2 (NleH2), display sequence similarity to Shigella flexneri OspG, which inhibits activation of the pro-inflammatory transcription factor NF-κB. We hypothesized that the anti-inflammatory effects of EPEC were mediated by NleH1 and NleH2. In this study, we examined the effect of NleH1/H2 on the NF-κB pathway. We show that NleH1/H2 are secreted via the T3SS and that transfection of cells with plasmids harbouring nleH1 or nleH2 decreased IKK-β-induced NF-κB activity and attenuated TNF-α-induced degradation of phospho-IκBα by preventing ubiquitination. Serum KC levels were higher in mice infected with ΔnleH1H2 than those infected with WT EPEC, indicating that NleH1/H2 dampen pro-inflammatory cytokine expression. ΔnleH1H2 was cleared more rapidly than WT EPEC while complementation of ΔnleH1H2 with either NleH1 or NleH2 prolonged colonization. Together, these data show that NleH1 and NleH2 function to dampen host inflammation and facilitate EPEC colonization during pathogenesis. © 2010 Blackwell Publishing Ltd.

  13. Practical aspects of Lee Goldburg based CRAMPS techniques for high-resolution 1H NMR spectroscopy in solids: Implementation and applications

    Science.gov (United States)

    Coelho, Cristina; Rocha, João; Madhu, P. K.; Mafra, Luís

    2008-10-01

    Elucidating the local environment of the hydrogen atoms is an important problem in materials science. Because 1H spectra in solid-state nuclear magnetic resonance (NMR) suffer from low resolution due to homogeneous broadening, even under magic-angle spinning (MAS), information of chemical interest may only be obtained using certain high-resolution 1H MAS techniques. 1H Lee-Goldburg (LG) CRAMPS (Combined Rotation And Multiple-Pulse Spectroscopy) methods are particularly well suited for studying inorganic-organic hybrid materials, rich in 1H nuclei. However, setting up CRAMPS experiments is time-consuming and not entirely trivial, facts that have discouraged their widespread use by materials scientists. To change this status quo, here we describe and discuss some important aspects of the experimental implementation of CRAMPS techniques based on LG decoupling schemes, such as FSLG (Frequency Switched), and windowed and windowless PMLG (Phase Modulated). In particular, we discuss the influence on the quality of the 1H NMR spectra of the different parameters at play, for example LG (Lee-Goldburg) pulses, radio-frequency ( rf) phase, frequency switching, and pulse imperfections, using glycine and adamantane as model compounds. The efficiency and robustness of the different LG-decoupling schemes is then illustrated on the following materials: organo-phosphorus ligand, N-(phosphonomethyl)iminodiacetic acid [H 4pmida] [I], and inorganic-organic hybrid materials (C 4H 12N 2)[Ge 2(pmida) 2OH 2]·4H 2O [II] and (C 2H 5NH 3)[Ti(H 1.5PO 4)(PO 4)] 2·H 2O [III].

  14. Mesophilic and thermophilic anaerobic co-digestion of winery wastewater sludge and wine lees: An integrated approach for sustainable wine production.

    Science.gov (United States)

    Da Ros, C; Cavinato, C; Pavan, P; Bolzonella, D

    2017-12-01

    In this work, winery wastes generated by a cellar producing approximately 300,000 hL of wine per year was monitored for a period of one year. On average, 196 L of wastewater, 0.1 kg of waste activated sludge (dry matter) and 1.6 kg of wine lees were produced per hectoliter of wine produced. Different winery wastes, deriving from different production steps, namely waste activated sludge from wastewater treatment and wine lees, were co-treated using an anaerobic digestion process. Testing was conducted on a pilot scale for both mesophilic and thermophilic conditions. The process was stable for a long period at 37 °C, with an average biogas production of 0.386 m 3 /kg COD fed . On the other hand, for thermophilic conditions, volatile fatty acids accumulated in the reactor and the process failed after one hydraulic retention time (23 days). In order to fix the biological process, trace elements (iron, cobalt and nickel) were added to the feed of the thermophilic reactor. Metals augmentation improved process stability and yields at 55 °C. The pH ranged between 7.8 and 8.0, and specific gas production was 0.450 m 3 /kg COD fed , which corresponded to dry matter and COD removals of 34% and 88%, respectively. Although the observed performances in terms of biogas production were good, the thermophilic process exhibited some limitations related to both the necessity of metals addition and the worse dewaterability properties. In fact, while the mesophilic digestates reached a good dewatering quality via the addition of 6.5 g of polymer per kg of dry matter, the required dosage for the thermophilic sludge was greater than 10 g/kg of dry matter. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Tratamento dos distúrbios da voz na doença de Parkinson: o método Lee Silverman

    Directory of Open Access Journals (Sweden)

    Dias Alice Estevo

    2003-01-01

    Full Text Available Alterações discretas na qualidade da voz e da articulação podem ser observadas em fases relativamente iniciais da doença de Parkinson (DP. As alterações da voz e da fala na DP constituem, em conjunto, o que se denomina disartria hipocinética ou disartrofonia e caracterizam-se por monotonia e redução da intensidade da voz, articulação imprecisa e distúrbios do ritmo. Recentemente, foram relatados resultados favoráveis através de método de tratamento intensivo e dirigido especificamente para o tratamento da voz na DP, denominado Lee Silverman Voice Treatment (LSVT®. O objetivo essencial desse método é aumentar a intensidade vocal através do incremento do esforço fonatório. O presente estudo teve por objetivo a caracterização das anormalidades vocais (qualidade vocal, padrão articulatório e inteligibilidade em um grupo de pacientes com DP e a avaliação da resposta terapêutica obtida pela administração do método Lee Silverman. A comparação dos dados de análise acústica, bem como da análise perceptivo-auditiva nos períodos pré e pós-tratamento mostraram modificações estatisticamente significantes após o tratamento. Embora o padrão articulatório tenha se mantido impreciso, os benefícios obtidos pelo tratamento na melhora da qualidade vocal e, sobretudo, na intensidade vocal favoreceram a qualidade da comunicação oral, reduziram os sintomas negativos e adequaram a qualidade vocal às necessidades pessoais e sociais dos indivíduos.

  16. Kinematograafiline rätsepakunst / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017

    2007-01-01

    Taivani päritolu režissöör Ang Lee tema mängufilm "Mõistus ja tunded" ("Sense and Sensibility") : stsenarist Jane Austeni romaani põhjal Emma Thompson : Suurbritannia - Ameerika Ühendriigid 2005

  17. The effects of Hurricane Irene and Tropical Storm Lee on the bed sediment geochemistry of U.S. Atlantic coastal rivers

    Science.gov (United States)

    Horowitz, Arthur J.

    2013-01-01

    Hurricane Irene and Tropical Storm Lee, both of which made landfall in the U.S. between late August and early September 2011, generated record or near record water discharges in 41 coastal rivers between the North Carolina/South Carolina border and the U.S./Canadian border. Despite the discharge of substantial amounts of suspended sediment from many of these rivers, as well as the probable influx of substantial amounts of eroded material from the surrounding basins, the geochemical effects on the wastewater/solid sludge. The limited number of significant sediment-associated chemical changes that were detected probably resulted from two potential processes: (1) the flushing of in-stream land-use affected sediments that were replaced by baseline material more representative of local geology and/or soils (declining concentrations), and/or (2) the inclusion of more heavily affected material as a result of urban nonpoint-source runoff and/or releases from flooded treatment facilities (increasing concentrations). Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

  18. Social networks and inference about unknown events: A case of the match between Google’s AlphaGo and Sedol Lee

    Science.gov (United States)

    Bae, Jonghoon; Cha, Young-Jae; Lee, Hyungsuk; Lee, Boyun; Baek, Sojung; Choi, Semin

    2017-01-01

    This study examines whether the way that a person makes inferences about unknown events is associated with his or her social relations, more precisely, those characterized by ego network density that reflects the structure of a person’s immediate social relation. From the analysis of individual predictions over the Go match between AlphaGo and Sedol Lee in March 2016 in Seoul, Korea, this study shows that the low-density group scored higher than the high-density group in the accuracy of the prediction over a future state of a social event, i.e., the outcome of the first game. We corroborated this finding with three replication tests that asked the participants to predict the following: film awards, President Park’s impeachment in Korea, and the counterfactual assessment of the US presidential election. Taken together, this study suggests that network density is negatively associated with vision advantage, i.e., the ability to discover and forecast an unknown aspect of a social event. PMID:28222114

  19. Time-lapse analysis of methane quantity in Mary Lee group of coal seams using filter-based multiple-point geostatistical simulation

    Science.gov (United States)

    Karacan, C. Özgen; Olea, Ricardo A.

    2013-01-01

    Coal seam degasification and its success are important for controlling methane, and thus for the health and safety of coal miners. During the course of degasification, properties of coal seams change. Thus, the changes in coal reservoir conditions and in-place gas content as well as methane emission potential into mines should be evaluated by examining time-dependent changes and the presence of major heterogeneities and geological discontinuities in the field. In this work, time-lapsed reservoir and fluid storage properties of the New Castle coal seam, Mary Lee/Blue Creek seam, and Jagger seam of Black Warrior Basin, Alabama, were determined from gas and water production history matching and production forecasting of vertical degasification wellbores. These properties were combined with isotherm and other important data to compute gas-in-place (GIP) and its change with time at borehole locations. Time-lapsed training images (TIs) of GIP and GIP difference corresponding to each coal and date were generated by using these point-wise data and Voronoi decomposition on the TI grid, which included faults as discontinuities for expansion of Voronoi regions. Filter-based multiple-point geostatistical simulations, which were preferred in this study due to anisotropies and discontinuities in the area, were used to predict time-lapsed GIP distributions within the study area. Performed simulations were used for mapping spatial time-lapsed methane quantities as well as their uncertainties within the study area.

  20. Kuidas suunata noori loodusest hoolima? / Jane Adler

    Index Scriptorium Estoniae

    Adler, Jane

    2008-01-01

    Kuusalu keskkoolis toimunud ökotantsufestivalist. Kolm peapreemiat anti välja parimatele looduse jäljendajatele: Keila lasteaiale "Vikerkaar" kava "Linnud ja meri" eest, Petsi spordiklubile (1.-3. klass) kava "Kärbeste ralli" eest ning Kunda ühisgümnaasiumile (10.-12. klass) kava "Elu" eest

  1. 20 aastat Berliini meediakunsti festivali / Jane Suviste

    Index Scriptorium Estoniae

    Suviste, Jane

    2008-01-01

    Rahvusvaheline meediakunsti festival "Transmediale 2008" Berliinis 29. I-3. II ja näitus 29. I-24. II. Näitusest "Conspire / Salanõu" (kuraator Natasha Petreshin Bachelez), konverentsist, kolme Janez Jansha pseudonüümiga sloveeni kunstniku probleeme tekitanud performance'ist "Signature. Event. Context" jm. Peaauhind läks Julia Meltzeri ja David Thorne'i videole "Not a Matter of If but When"

  2. Living with diversity in Jane-Finch

    NARCIS (Netherlands)

    Ahmadi, D.

    2017-01-01

    In the past decades, diversity has become a popular catchphrase in theoretical, policy and public discourses in Canadian cities.

    This study seeks to add to our understanding of urban diversity, as perceived and experienced by those who inhabit, frequent and govern urban areas. The study

  3. Jane: A Case Study in Anorexia Nervosa.

    Science.gov (United States)

    Willingham, Barbara

    1988-01-01

    The article reports the case history of a 15-year-old Australian girl with anorexia nervosa. Information is also given on prevalence, causes, definitions, and treatments including hospitalization, co-therapy, psychotherapy, behavior modification, family therapy, and counseling. (DB)

  4. Crescimento de Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. e Enterolobium contortisiliquum (Vell. Morong (Leguminosae sob diferentes níveis de sombreamento Growth of Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. e Enterolobium contortisiliquum (Vell. Morong (Leguminosae under different shading levels

    Directory of Open Access Journals (Sweden)

    Ana Lúcia da Silva Lima

    2010-03-01

    Full Text Available Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. é uma espécie clímax tolerante a sombra, ao passo que Enterolobium contortisiliquum (Vell. Morong. é uma espécie pioneira. O desenvolvimento destas espécies pode refletir a habilidade de adaptação aos diferentes fatores ambientais (luz, água e temperatura no local em que estão crescendo. O suprimento inadequado de um desses fatores pode reduzir o vigor da planta e limitar seu desenvolvimento. O presente trabalho teve como objetivo avaliar os efeitos do nível de sombreamento no crescimento e a concentração de pigmentos fotossintéticos em duas espécies de leguminosas arbóreas, Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. e Enterolobium contortisiliquum (Vell. Morong. O experimento foi conduzido no Setor de Olericultura do Centro Universitário Luterano de Ji-Paraná (CEULJI/ULBRA/Rondônia. Durante a formação das mudas, ambas as espécies foram expostas a quatro tratamentos de sombra: 0 % (controle - sol pleno; 30 %; 50 % e 80 %. Cada tratamento foi constituído com três repetições de cada espécie; o delineamento experimental foi inteiramente casualisado. Quatro meses após a semeadura, as seguintes análises foram realizadas: número de folhas, altura da planta, comprimento do sistema radicular, massa seca total e concentração de pigmentos fotossintéticos. O tratamento sob sol pleno afetou negativamente o crescimento de ambas as espécies. As mudas crescidas sob 50% e 80% apresentaram melhor desenvolvimento. Conforme o aumento do sombreamento houve um decréscimo na razão clorofila a/b e um aumento nas concentrações de clorofila total e carotenóides totais.Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. is a clímax shadow tolerant specie and Enterolobium contortisiliquum (Vell. Morong., by the other hand, is considered as a pioneer specie. The development of these species may reflect its adaptation ability to different environmental

  5. Βιβλιοκρισία του: GARY VIKAN, Early Byzantine Pilgrimage Art. Revised Edition (first published 1982. Dumbarton Oaks Byzantine Collection Publications 5, Washington DC: Dumbarton Oaks Research Library and Collection, Trustees for Harvard University, 2011

    Directory of Open Access Journals (Sweden)

    Anastasia G. YANGAKI

    2012-10-01

    Full Text Available book review: Gary Vikan, Early Byzantine Pilgrimage Art. Revised Edition (first published 1982. Dumbarton Oaks Byzantine Collection Publications 5, Washington DC: Dumbarton Oaks Research Library and Collection, Trustees for Harvard University pp. 109. ISBN: 978-0-88402-358-6.

  6. The effectiveness of Lee Silverman Voice Treatment therapy issued interactively through an iPad device: A non-inferiority study.

    Science.gov (United States)

    Griffin, Murray; Bentley, John; Shanks, Joseph; Wood, Carly

    2018-04-01

    Introduction This study compared the differences in recorded speech variables between people treated with conventional 'in person' Lee Silverman Voice Treatment (LSVT) and those treated remotely via iPad-based 'Facetime'. Method Eight participants were selected for the iPad LSVT, and 21 similarly matched subjects were selected from existing data to form the 'in person' group. Participants in both groups had diagnosed idiopathic Parkinson's disease and moderate hypokinetic dysarthria. Eighteen sessions of prescribed LSVT comprising a pre-treatment assessment, 16 treatment sessions, and a six months' post-treatment assessment were administered for each person. In both groups, pre- and post-treatment assessments were conducted face-to-face. Performance measures were recorded during assessment and treatment. Average measures were determined for all tasks at all time points and a summary outcome variable was composed from across-task performance. Results Non-inferiority testing confirmed that iPad LSVT was non-inferior in treating all LSVT task 3 variables except generating words, with the 90% upper confidence intervals (CI) lying between the non-inferiority margin of ± 2.25 and zero. The iPad was superior in treating the task 3 rainbow reading passage and describing motor task variables with upper and lower 90% CI values being negative. The improvement in the summary outcome variable score was also superior in the iPad group. Discussion Non-inferiority testing implies that the iPad LSVT is non-inferior in treating task three variables when compared to traditional LSVT. The study supports further development of remote delivery solutions involving the Apple iPad and 'Facetime' system as a means of improving access to services and the participant's experience.

  7. Use of Antibody Responses against Locus of Enterocyte Effacement (LEE)-Encoded Antigens To Monitor Enterohemorrhagic Escherichia coli Infections on Cattle Farms

    Science.gov (United States)

    Joris, Maria-Adelheid; Vanrompay, Daisy; Verstraete, Karen; De Reu, Koen; De Zutter, Lieven

    2013-01-01

    Enterohemorrhagic Escherichia coli (EHEC) is a significant zoonotic pathogen causing severe disease associated with watery and bloody diarrhea, hemorrhagic colitis, and the hemolytic-uremic syndrome (HUS) in humans. Infections are frequently associated with contact with EHEC-contaminated ruminant feces. Both natural and experimental infection of cattle induces serum antibodies against the LEE-encoded proteins intimin, EspA, EspB, and Tir and the Shiga toxins Stx1 and Stx2, although the latter are poorly immunogenic in cattle. We determined whether antibodies and/or the kinetics of antibody responses against intimin, Tir, EspA, and/or EspB can be used for monitoring EHEC infections in beef cattle herds in order to reduce carcass contamination at slaughter. We examined the presence of serum antibodies against recombinant O157:H7 E. coli intimin EspA, EspB, and Tir during a cross-sectional study on 12 cattle farms and during a longitudinal time course study on two EHEC-positive cattle farms. We searched for a possible correlation between intimin, Tir, EspA, and/or EspB antibodies and fecal excretion of EHEC O157, O145, O111, O103, or O26 seropathotypes. The results indicated that serum antibody responses to EspB and EspA might be useful for first-line screening at the herd level for EHEC O157, O26, and most likely also for EHEC O103 infections. However, antibody responses against EspB are of less use for monitoring individual animals, since some EHEC-shedding animals did not show antibody responses and since serum antibody responses against EspB could persist for several months even when shedding had ceased. PMID:23563950

  8. Age and growth of European barbel Barbus barbus (Cyprinidae in the small, mesotrophic River Lee and relative to other populations in England

    Directory of Open Access Journals (Sweden)

    Vilizzi L.

    2013-08-01

    Full Text Available Suspected of being in decline, the European barbel Barbus barbus population of the River Lee, a heavily-modified river in South East England, has been the subject of investigations to identify factors associated with perceived population decreases. Population surveys between 1995 and 1999 captured a total of 912 individuals, and standard length (SL frequency analyses between years suggested that the population decline was not related to juvenile recruitment but rather to a recruitment bottleneck in fish 300–340 mm SL. This bottleneck probably results from insufficient available habitat suitable to this size class. Of the sampled fish, scales were removed from 764 and were used in a scale ageing exercise among three researchers. Analyses of their independent age estimates revealed variable interpretations, which arose from uncertainties relating to the difficulty of analysing scale patterns from relatively large, slow-growing fish. Nevertheless, error was within published acceptable margins, and age estimates revealed B. barbus in the river to age 10 years, lower than in many UK rivers. The SL-at-age growth curve was characterised by very fast growth in the initial years of life. Thus, the causal factors in the decline of this B. barbus population appear to have been in the adult life-stage habitat and were likely related to the loss of longitudinal connectivity, mainly due to the presence of water retention structures. River and aquatic ecosystem remediation strategies should therefore focus on enhancing longitudinal connectivity in conjunction with the ongoing improvement of water quality and ecosystem integrity.

  9. Long-term effects of Lee Silverman Voice Treatment on daily voice use in Parkinson's disease as measured with a portable voice accumulator.

    Science.gov (United States)

    Körner Gustafsson, Joakim; Södersten, Maria; Ternström, Sten; Schalling, Ellika

    2018-02-15

    This study examines the effects of an intensive voice treatment focusing on increasing voice intensity, LSVT LOUD ® Lee Silverman Voice Treatment, on voice use in daily life in a participant with Parkinson's disease, using a portable voice accumulator, the VoxLog. A secondary aim was to compare voice use between the participant and a matched healthy control. Participants were an individual with Parkinson's disease and his healthy monozygotic twin. Voice use was registered with the VoxLog during 9 weeks for the individual with Parkinson's disease and 2 weeks for the control. This included baseline registrations for both participants, 4 weeks during LSVT LOUD for the individual with Parkinson's disease and 1 week after treatment for both participants. For the participant with Parkinson's disease, follow-up registrations at 3, 6, and 12 months post-treatment were made. The individual with Parkinson's disease increased voice intensity during registrations in daily life with 4.1 dB post-treatment and 1.4 dB at 1-year follow-up compared to before treatment. When monitored during laboratory recordings an increase of 5.6 dB was seen post-treatment and 3.8 dB at 1-year follow-up. Changes in voice intensity were interpreted as a treatment effect as no significant correlations between changes in voice intensity and background noise were found for the individual with Parkinson's disease. The increase in voice intensity in a laboratory setting was comparable to findings previously reported following LSVT LOUD. The increase registered using ambulatory monitoring in daily life was lower but still reflecting a clinically relevant change.

  10. HYDRAULICS, LEE COUNTY, GEORGIA, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  11. Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson's disease: a pilot randomised controlled trial (PD COMM pilot).

    Science.gov (United States)

    Sackley, Catherine M; Smith, Christina H; Rick, Caroline E; Brady, Marian C; Ives, Natalie; Patel, Smitaa; Woolley, Rebecca; Dowling, Francis; Patel, Ramilla; Roberts, Helen; Jowett, Sue; Wheatley, Keith; Kelly, Debbie; Sands, Gina; Clarke, Carl E

    2018-01-01

    Speech-related problems are common in Parkinson's disease (PD), but there is little evidence for the effectiveness of standard speech and language therapy (SLT) or Lee Silverman Voice Treatment (LSVT LOUD®). The PD COMM pilot was a three-arm, assessor-blinded, randomised controlled trial (RCT) of LSVT LOUD®, SLT and no intervention (1:1:1 ratio) to assess the feasibility and to inform the design of a full-scale RCT. Non-demented patients with idiopathic PD and speech problems and no SLT for speech problems in the past 2 years were eligible. LSVT LOUD® is a standardised regime (16 sessions over 4 weeks). SLT comprised individualised content per local practice (typically weekly sessions for 6-8 weeks). Outcomes included recruitment and retention, treatment adherence, and data completeness. Outcome data collected at baseline, 3, 6, and 12 months included patient-reported voice and quality of life measures, resource use, and assessor-rated speech recordings. Eighty-nine patients were randomised with 90% in the therapy groups and 100% in the control group completing the trial. The response rate for Voice Handicap Index (VHI) in each arm was ≥ 90% at all time-points. VHI was highly correlated with the other speech-related outcome measures. There was a trend to improvement in VHI with LSVT LOUD® (difference at 3 months compared with control: - 12.5 points; 95% CI - 26.2, 1.2) and SLT (difference at 3 months compared with control: - 9.8 points; 95% CI - 23.2, 3.7) which needs to be confirmed in an adequately powered trial. Randomisation to a three-arm trial of speech therapy including a no intervention control is feasible and acceptable. Compliance with both interventions was good. VHI and other patient-reported outcomes were relevant measures and provided data to inform the sample size for a substantive trial. International Standard Randomised Controlled Trial Number Register: ISRCTN75223808. registered 22 March 2012.

  12. "¿Entiendes, con seguridad, lo que lees?" Hch 8, 30 Caminos de la hermenéutica de [en] la Escritura

    Directory of Open Access Journals (Sweden)

    Ignacio Chuecas Saldías

    2005-01-01

    Full Text Available El presente artículo busca ser una contribución para una hermenéutica bíblica práctica: es decir, no mira hacia la teoría de la interpretación, sino más bien hacia la praxis actual, especialmente en el campo de los estudios sincrónicos. Al mismo tiempo, pretende invitar al lector a conocer los métodos hermenéuticos propios de la tradición del Nuevo Testamento. Es a través de los caminos del midrash judeocristiano que nos acercamos a la praxis hermenéutica de los escritores bíblicos. El objetivo propuesto es llevado a cabo empleando como guía hermenéutica, a la vez que como laboratorio donde se ejemplifican los principios expuestos, el texto bíblico del encuentro del evangelista Felipe y el ministro de la reina de Etiopía (Hechos 8, 20-40. La pregunta de Felipe sirve de leitmotiv a este proceso: ¿entiendes, con certeza, lo que lees? Hermenéutica bíblica es siempre una manera de leer donde la escritura se interpreta a sí misma. El artículo presta especial atención a las categorías y herramientas de interpretación que se han desarrollado a partir de las nuevas impostaciones literarias en el campo de la exégesis bíblicaThe article attempts to make a contribution to the practical biblical hermeneutics focusing on the actual praxis, especially exploring the field of synchronic studies, rather than on the theory of interpretation. It also aims at offering an insight to the hermeneutic methods of the New Testament tradition, approaching the hermeneutic praxis of the biblical writers through the judeo-christian midrash paths. The accomplish such an objective, the author focuses on the biblical text of Philip's encounter with the minister of the queen of Ethiopia (Acts, 8, 20-40 as the hermeneutic guide and source to illustrate the principles being exposed. Philip's question "Can you really understand what you are reading?" serves as leitmotif to this process, as the biblical hermeneutics is a way of reading inwhich the

  13. Waste Conversion into n-Caprylate and n-Caproate: Resource Recovery from Wine Lees Using Anaerobic Reactor Microbiomes and In-line Extraction.

    Science.gov (United States)

    Kucek, Leo A; Xu, Jiajie; Nguyen, Mytien; Angenent, Largus T

    2016-01-01

    To convert wastes into sustainable liquid fuels and chemicals, new resource recovery technologies are required. Chain elongation is a carboxylate-platform bioprocess that converts short-chain carboxylates (SCCs) (e.g., acetate [C2] and n-butyrate [C4]) into medium-chain carboxylates (MCCs) (e.g., n-caprylate [C8] and n-caproate [C6]) with hydrogen gas as a side product. Ethanol or another electron donor (e.g., lactate, carbohydrate) is required. Competitive MCC productivities, yields (product vs. substrate fed), and specificities (product vs. all products) were only achieved previously from an organic waste material when exogenous ethanol had been added. Here, we converted a real organic waste, which inherently contains ethanol, into MCCs with n-caprylate as the target product. We used wine lees, which consisted primarily of settled yeast cells and ethanol from wine fermentation, and produced MCCs with a reactor microbiome. We operated the bioreactor at a pH of 5.2 and with continuous in-line extraction and achieved a MCC productivity of 3.9 g COD/L-d at an organic loading rate of 5.8 g COD/L-d, resulting in a promising MCC yield of 67% and specificities of 36% for each n-caprylate and n-caproate (72% for both). Compared to all other studies that used complex organic substrates, we achieved the highest n-caprylate-to-ncaproate product ratio of 1.0 (COD basis), because we used increased broth-recycle rates through the forward membrane contactor, which improved in-line extraction rates. Increased recycle rates also allowed us to achieve the highest reported MCC production flux per membrane surface area thus far (20.1 g COD/m 2 -d). Through microbial community analyses, we determined that an operational taxonomic unit (OTU) for Bacteroides spp. was dominant and was positively correlated with increased MCC productivities. Our data also suggested that the microbiome may have been shaped for improved MCC production by the high broth-recycle rates. Comparable abiotic

  14. Waste conversion into n-caprylate and n-caproate: resource recovery from wine lees using anaerobic reactor microbiomes and in-line extraction

    Directory of Open Access Journals (Sweden)

    Leo A. Kucek

    2016-11-01

    Full Text Available To convert wastes into sustainable liquid fuels and chemicals, new resource recovery technologies are required. Chain elongation is a carboxylate-platform bioprocess that converts short-chain carboxylates (SCCs (e.g., acetate C2 and n-butyrate C4 into medium-chain carboxylates (MCCs (e.g., n-caprylate C8 and n-caproate C6 with hydrogen gas as a side product. Ethanol or another electron donor (e.g., lactate, carbohydrate is required. Competitive MCC productivities, yields (product vs. substrate fed, and specificities (product vs. all products were only achieved previously from an organic waste material when exogenous ethanol had been added. Here, we converted a real organic waste, which inherently comprised of ethanol, into MCCs with n-caprylate as the target product. We used wine lees, which consisted primarily of settled yeast cells and ethanol from wine fermentation, and produced MCCs with a reactor microbiome. We operated the bioreactor at a pH of 5.2 and with continuous in-line extraction and achieved a MCC productivity of 3.9 g COD/L-d at an organic loading rate of 5.8 g COD/L-d, resulting in a promising MCC yield of 67% and specificities of 36% for each n-caprylate and n-caproate (72% for both. Compared to all other studies that used complex organic substrates, we achieved the highest n-caprylate-to-n-caproate product ratio of 1.0 (COD basis, because we used increased broth-recycle rates through the forward membrane contactor, which improved in-line extraction rates. Increased recycle rates also allowed us to achieve the highest reported MCC production flux per membrane surface area thus far (20.1 g COD/m2-d. Through microbial community analyses, we determined that an operational taxonomic unit (OTU for Bacteroides spp. was dominant and was positively correlated with increased MCC productivities. Our data also suggested that the microbiome may have been shaped for improved MCC production by the high broth-recycle rates. Comparable abiotic

  15. Status and trends of the rainbow trout population in the Lees Ferry reach of the Colorado River downstream from Glen Canyon Dam, Arizona, 1991–2009

    Science.gov (United States)

    Makinster, Andrew S.; Persons, William R.; Avery, Luke A.

    2011-01-01

    The Lees Ferry reach of the Colorado River, a 25-kilometer segment of river located immediately downstream from Glen Canyon Dam, has contained a nonnative rainbow trout (Oncorhynchus mykiss) sport fishery since it was first stocked in 1964. The fishery has evolved over time in response to changes in dam operations and fish management. Long-term monitoring of the rainbow trout population downstream of Glen Canyon Dam is an essential component of the Glen Canyon Dam Adaptive Management Program. A standardized sampling design was implemented in 1991 and has changed several times in response to independent, external scientific-review recommendations and budget constraints. Population metrics (catch per unit effort, proportional stock density, and relative condition) were estimated from 1991 to 2009 by combining data collected at fixed sampling sites during this time period and at random sampling sites from 2002 to 2009. The validity of combining population metrics for data collected at fixed and random sites was confirmed by a one-way analysis of variance by fish-length class size. Analysis of the rainbow trout population metrics from 1991 to 2009 showed that the abundance of rainbow trout increased from 1991 to 1997, following implementation of a more steady flow regime, but declined from about 2000 to 2007. Abundance in 2008 and 2009 was high compared to previous years, which was likely the result of increased early survival caused by improved habitat conditions following the 2008 high-flow experiment at Glen Canyon Dam. Proportional stock density declined between 1991 and 2006, reflecting increased natural reproduction and large numbers of small fish in samples. Since 2001, the proportional stock density has been relatively stable. Relative condition varied with size class of rainbow trout but has been relatively stable since 1991 for fish smaller than 152 millimeters (mm), except for a substantial decrease in 2009. Relative condition was more variable for larger

  16. Comparative Study of Three Vaccinal Strains of Clostridium tetani Including Harvard 52, G5 and 49205 from Standpoint of Six Essential Factors to Evaluate Their Toxigenesis for Use in Tetanus Vaccine Production

    Directory of Open Access Journals (Sweden)

    Motedayen, M.H.

    2012-11-01

    Full Text Available Tetanus is an important disease which created by tetanospasmin toxin of Clostridium tetani. In this study we surveyed six important factors including LF, KF, MLD, pH, OD and total protein assay of Harvard 52 (H52, G5 (HG5 and 49205 (H49205 strains of the bacterium to determine which of them were more suitable for use in vaccine production. The mentioned strains were seperatedly reactivated in thioglycolate medium, 2ml of this suspension was used to inoculate the Muller-Miller medium of each of sixteen 500 ml Erlenmeyer flasks (7,6 and 3 flasks for H52, HG5 and H49205 respectively, where the fermentation runs were performed. Over a period of seven days of experiment, several tests for evaluation of the six mentioned factors on samples of medium cultures were carried out. Results revealed that H52 strain had significantly lower values in LF and OD compared to strains HG5 & H49205 (P<0.001 and P<0.01 respectively while its MLD and pH were better than other strains (P< 0.05 and P< 0.02 respectively. In conclusion, it seems that HG5 & H49205 strains have been greater toxin producer than H52 strain and as a result, we hope that with some complementary works, these two strains such as H52 strain, be used for routine tetanus vaccine production.

  17. Policies to increase the social value of science and the scientist satisfaction. An exploratory survey among Harvard bioscientists. [v2; ref status: indexed, http://f1000r.es/3jw

    Directory of Open Access Journals (Sweden)

    Andrea Ballabeni

    2014-06-01

    Full Text Available Basic research in the biomedical field generates both knowledge that has a value per se regardless of its possible practical outcome and knowledge that has the potential to produce more practical benefits. Policies can increase the benefit potential to society of basic biomedical research by offering various kinds of incentives to basic researchers. In this paper we argue that soft incentives or “nudges” are particularly promising. However, to be well designed, these incentives must take into account the motivations, goals and views of the basic scientists. In the paper we present the results of an investigation that involved more than 300 scientists at Harvard Medical School and affiliated institutes. The results of this study suggest that some soft incentives could be valuable tools to increase the transformative value of fundamental investigations without affecting the spirit of the basic research and scientists’ work satisfaction. After discussing the findings, we discuss a few examples of nudges for basic researchers in the biomedical fields.

  18. Policies to increase the social value of science and the scientist satisfaction. An exploratory survey among Harvard bioscientists. [v1; ref status: indexed, http://f1000r.es/2iq

    Directory of Open Access Journals (Sweden)

    Andrea Ballabeni

    2014-01-01

    Full Text Available Basic research in the biomedical field generates both knowledge that has a value per se regardless of its possible practical outcome and that has the potential to produce more practical benefits. Policies can increase the benefit potential to society of basic biomedical research by offering various kinds of incentives to basic researchers. In this paper we argue that soft incentives or “nudges” are particularly promising. However, to be well designed, these incentives must take into account the motivations, goals and views of the basic scientists. In the paper we present the results of an investigation that involved more than 300 scientists at Harvard Medical School and affiliated institutes. The study shows that basic researchers’ support for soft incentives is such that the transformative value of fundamental investigations can be increased without affecting the spirit of the basic research and scientists’ work satisfaction. After discussing the findings, we suggest a few examples of nudges and discuss one in more detail.

  19. O ENSINO DE MATEMÁTICA NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL: O PROBLEMA DA FORMAÇÃO DO PROFESSOR E AS CONTRIBUIÇÕES DE LEE SHULMAN E DE V. V. DAVYDOV

    OpenAIRE

    Ferreira, Valdivina Alves; Freitas, Raquel Aparecida Marra da Madeira

    2014-01-01

    O objetivo deste texto é apresentar uma discussão crítica acerca da formação do professor que ensina matemática nos anos iniciais do Ensino Fundamental. Inicia-se pelo delineamento do problema das dificuldades de ensino e de aprendizagem de matemática, recorrentes nas pesquisas e nos discursos acadêmicos, destacando como um dos fatores a formação dos professores. Em seguida apresentam-se as contribuições de dois teóricos distintos, Lee Shulman e V. V Davydov, para o enfrentamento deste proble...

  20. MODIFICAÇÃO DO MÉTODO LEE SILVERMAN DE TRATAMENTO VOCAL NA DOENÇA DE PARKINSON: ANÁLISE PERCEPTIVO-AUDITIVA E ACÚSTICA COMPUTADORIZADA

    OpenAIRE

    Barros, Andréa Lopes de Souza Miranda de

    2006-01-01

    OBJETIVO: verificar a aplicabilidade do Lee Silverman Voice Treatment® numa freqüência diferenciada, em indivíduos portadores de DP, por meio de análise perceptivo-auditiva e acústica computadorizada vocal. PACIENTES E MÉTODO: o estudo foi realizado com 12 indivíduos portadores da DP classificados entre os graus 1 e 4 (escala Hoehn & Yahr), com queixas fonoaudiológicas, submetidos à modificação do LSVT® com aplicação em freqüência de duas vezes por semana, com duração de 45 ...

  1. Embodied Rhythm: Commentary on "The Contribution of Anthropometric Factors to Individual Differences in the Perception of Rhythm" by Neil P. McAngus Todd, Rosanna Cousins, and Christopher S. Lee

    Directory of Open Access Journals (Sweden)

    Bruno H. Repp

    2007-01-01

    Full Text Available Todd, Cousins, and Lee (2007 have presented some intriguing data suggesting that body size, as measured by standard anthropometric indices, is related to the preferred beat period in a perceptual task. Curiously, however, they did not find a significant sex difference, even though the women in their sample were clearly smaller than the men. Another recent study of preferred spontaneous tempo (McAuley et al., 2006 likewise failed to find a sex difference in a large sample of young adults. It is unclear why body size should have an effect only within each sex group.

  2. Time-Lapse Analysis of Methane Quantity in the Mary Lee Group of Coal Seams Using Filter-Based Multiple-Point Geostatistical Simulation.

    Science.gov (United States)

    Karacan, C Özgen; Olea, Ricardo A

    2013-08-01

    Coal seam degasification and its success are important for controlling methane, and thus for the health and safety of coal miners. During the course of degasification, properties of coal seams change. Thus, the changes in coal reservoir conditions and in-place gas content as well as methane emission potential into mines should be evaluated by examining time-dependent changes and the presence of major heterogeneities and geological discontinuities in the field. In this work, time-lapsed reservoir and fluid storage properties of the New Castle coal seam, Mary Lee/Blue Creek seam, and Jagger seam of Black Warrior Basin, Alabama, were determined from gas and water production history matching and production forecasting of vertical degasification wellbores. These properties were combined with isotherm and other important data to compute gas-in-place (GIP) and its change with time at borehole locations. Time-lapsed training images (TIs) of GIP and GIP difference corresponding to each coal and date were generated by using these point-wise data and Voronoi decomposition on the TI grid, which included faults as discontinuities for expansion of Voronoi regions. Filter-based multiple-point geostatistical simulations, which were preferred in this study due to anisotropies and discontinuities in the area, were used to predict time-lapsed GIP distributions within the study area. Performed simulations were used for mapping spatial time-lapsed methane quantities as well as their uncertainties within the study area. The systematic approach presented in this paper is the first time in literature that history matching, TIs of GIPs and filter simulations are used for degasification performance evaluation and for assessing GIP for mining safety. Results from this study showed that using production history matching of coalbed methane wells to determine time-lapsed reservoir data could be used to compute spatial GIP and representative GIP TIs generated through Voronoi decomposition

  3. Higher Education Tarred with a Harvard Brush.

    Science.gov (United States)

    Trachtenberg, Stephen Joel

    1987-01-01

    The Secretary of Education Bennett and Michael Kinsley in an article in the Wall Street Journal claim that colleges are wasteful and ineffective, but the picture they paint of American higher education is essentially mythical. Higher education is seen as a scapegoat for politicians in an election year. (MLW)

  4. Oligotyping reveals stronger relationship of organic soil bacterial community structure with N-amendments and soil chemistry in comparison to that of mineral soil at Harvard Forest, MA, USA

    Directory of Open Access Journals (Sweden)

    Swathi Anuradha Turlapati

    2015-02-01

    Full Text Available The impact of chronic nitrogen amendments on bacterial communities was evaluated at Harvard Forest, Petersham MA. Thirty soil samples (3 treatments x 2 soil horizons x 5 subplots were collected in 2009 from untreated (control, low nitrogen-amended (LN; 50 kg NH4NO3 ha-1 yr-1 and high nitrogen-amended (HN; 150 kg NH4NO3 ha-1 yr-1 plots. PCR-amplified partial 16S rDNA sequences made from soil DNA were subjected to pyrosequencing (Turlapati et al., 2013 and analyses using oligotyping. The parameters M (the minimum count of the most abundant unique sequence in an oligotype and s (minimum number of samples in which an oligotype is expected to be present had to be optimized for forest soils because of high diversity and the presence of rare organisms. Comparative analyses of the pyrosequencing data by oligotyping and OTU (Operational Taxonomic Unit clustering tools indicated that the former yields more refined units of taxonomy with sequence similarity of ≥99.5%. Sequences affiliated with 4 new phyla and 73 genera were identified in the present study as compared to 27 genera reported earlier from the same data (Turlapati et al., 2013. Significant rearrangements in the bacterial community structure were observed with N-amendments revealing the presence of additional genera in N-amended plots with the absence of some that were present in the control plots. Permutational MANOVA analyses indicated significant variation associated with soil horizon and N treatment for a majority of the phyla. In most cases soil horizon partitioned more variation relative to treatment and treatment effects were more evident for the organic horizon. Mantel test results for organic soil showed significant positive correlations between bacterial communities and most soil parameters including NH4 and NO3. In mineral soil, correlations were seen only with pH, NH4 and NO3. Regardless of the pipeline used, a major hindrance for such a study remains to be the lack of reference

  5. Femmes aux petits soins : la fêlure d’un idéal dans deux nouvelles de F.S. Fitzgerald The Lees of Happiness et An Alcoholic Case

    OpenAIRE

    DELESALLE-NANCEY, Catherine

    2017-01-01

    Écrites à 17 ans d’intervalle, ces deux nouvelles de Fitzgerald mettent en scène des artistes dont la maladie pour l’un (« The Lees of Happiness ») et l’alcoolisme pour l’autre (« An Alcoholic Case ») ont eu raison des facultés créatrices. Pourtant, l’attention se porte moins sur les malades que sur celles qui les soignent, et embrassent ainsi un rôle traditionnellement dévolu aux femmes : l’épouse aimante sacrifiant tout pour son mari grabataire et l’infirmière dévouée investie d’une mission...

  6. Protective efficacy in mice of monovalent and trivalent live attenuated influenza vaccines in the background of cold-adapted A/X-31 and B/Lee/40 donor strains.

    Science.gov (United States)

    Jang, Yo Han; Lee, Eun-Young; Byun, Young Ho; Jung, Eun-Ju; Lee, Yoon Jae; Lee, Yun Ha; Lee, Kwang-Hee; Lee, Jinhee; Seong, Baik Lin

    2014-01-23

    Influenza virus continues to take a heavy toll on human health and vaccination remains the mainstay of efforts to reduce the clinical impact imposed by viral infections. Proven successful for establishing live attenuated vaccine donor strains, cold-adapted live attenuated influenza vaccines (CAIVs) have become an attractive modality for controlling the virus infection. Previously, we developed the cold-adapted strains A/X-31 and B/Lee/40 as novel donor strains of CAIVs against influenza A and B viruses. In this study, we investigated the protective immune responses of both mono- and trivalent vaccine formulations in the mouse model. Two type A vaccines and one type B vaccine against A/New Caledonia/20/99 (H1N1), A/Panama/2007/99 (H3N2), and B/Shangdong/7/97 in the background of the A/X-31 ca or B/Lee/40 ca were generated by a reassortment procedure and evaluated for their immunogenicity and protective efficacy. Each monovalent vaccine elicited high levels of serum antibodies and conferred complete protection against homologous wild type virus infection. As compared to the monovalent vaccines, trivalent formulation induced higher levels of type A-specific serum antibodies and slightly lower levels of type B-specific antibodies, suggesting an immunological synergism within type A viruses and an interference in the replication of type B virus. Relatively lower type B-specific immunogenicity in trivalent vaccine formulation could be effectively implemented by increasing the vaccine dose of influenza B virus. These results of immunogenicity, protection efficacy, and immunological synergism between type A vaccines provide an experimental basis for optimal composition of trivalent vaccines for subsequent developments of multivalent CAIVs against seasonal and pandemic influenza viruses. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Flux of nitrogen, phosphorus, and suspended sediment from the Susquehanna River Basin to the Chesapeake Bay during Tropical Storm Lee, September 2011, as an indicator of the effects of reservoir sedimentation on water quality

    Science.gov (United States)

    Hirsch, Robert M.

    2012-01-01

    Concentrations of nitrogen, phosphorus, and suspended sediment are measured at the U.S. Geological Survey streamgage at Conowingo Dam at the downstream end of the Susquehanna River Basin in Maryland, where the river flows into the Chesapeake Bay. During the period September 7-15, 2011, in the aftermath of Tropical Storm Lee, concentrations of these three constituents were among the highest ever measured at this site. These measurements indicate that sediment-storage processes behind the three dams on the lower Susquehanna River are evolving. In particular, they indicate that scouring of sediment (and the nitrogen and phosphorus attached to that sediment) may be increasing with time. Trends in flow-normalized fluxes at the Susquehanna River at Conowingo, Maryland, streamgage during 1996-2011 indicate a 3.2-percent decrease in total nitrogen, but a 55-percent increase in total phosphorus and a 97-percent increase in suspended sediment. These large increases in the flux of phosphorus and sediment from the Susquehanna River to the Chesapeake Bay have occurred despite reductions in the fluxes of these constituents from the Susquehanna River watershed upstream from the reservoirs. Although the Tropical Storm Lee flood event contributed about 1.8 percent of the total streamflow from the Susquehanna River to the Chesapeake Bay over the past decade (water years 2002-11), it contributed about 5 percent of the nitrogen, 22 percent of the phosphorus, and 39 percent of the suspended sediment during the same period. These results highlight the importance of brief high-flow events in releasing nitrogen, phosphorus, and sediment derived from the Susquehanna River watershed and stored in the Conowingo Reservoir to the Chesapeake Bay.

  8. Bibliografia

    OpenAIRE

    2016-01-01

    Agamben 1996 Giorgio Agamben, Mezzi senza fine, Bollati Boringhieri, Torino. Atkinson 2015 Anthony B. Atkinson, What Can be Done?, Harvard University Press, Harvard. Austen 1995 Jane Austen, Orgoglio e pregiudizio [1813], BUR, Milano. Balzac 1994 Honoré de Balzac, Papà Goriot [1842], in La commedia umana [1841], Mondadori Milano. Barthes 2002 Roland Barthes, Elementi di semiologia [1964], Einaudi, Torino 2002. 1991 Roland Barthes, L’avventura semiologica [1966-1985], Einaudi, Tori...

  9. 22nd September 2010 - Korean Minister of Education, Science and Technology J.-H. Lee signing the guest book and exchanging gifts with CERN Director-General R. Heuer and Head of International Relations F. Pauss; visiting ALICE exhibition with Collaboration Spokesperson J. Schukraft; accompanied throughout by Adviser R. Voss.

    CERN Multimedia

    Teams : M. Brice ; JC Gadmer

    2010-01-01

    22nd September 2010 - Korean Minister of Education, Science and Technology J.-H. Lee signing the guest book and exchanging gifts with CERN Director-General R. Heuer and Head of International Relations F. Pauss; visiting ALICE exhibition with Collaboration Spokesperson J. Schukraft; accompanied throughout by Adviser R. Voss.

  10. BIOSKETCH Andrej Šali received his BSc degree in chemistry from ...

    Indian Academy of Sciences (India)

    Savitha Sekhar Nair

    Birkbeck College, University of London, UK, in 1991, under the supervision of Professor Tom L. Blundell, where he developed the MODELLER program for comparative modeling of protein structures. He was then a postdoc with Professor Martin. Karplus at Harvard University as a Jane Coffin Childs Memorial. Fund fellow ...

  11. Observations of a thin near surface layer in an estuarine environment: An exceptional bloom of the dinoflagellate Akashiwo sanguinea in the Lee estuary (Lough Mahon), Co. Cork, in September 2010

    Science.gov (United States)

    O'Boyle, Shane; McDermott, Georgina

    2014-03-01

    Observations on the occurrence of an exceptional phytoplankton bloom in the Lee estuary, Co. Cork, in September 2010 are reported. A thin layer of phytoplankton dominated by the dinoflagellate Akashiwo sanguinea (Dinophyceae), with a cell concentration of 16,900 cells ml-1 and chlorophyll a concentration of 680 μg l-1, was observed at a depth of 1 m. The layer extended over a horizontal distance of 3 km and was located in the estuarine pycnocline. Levels of dissolved oxygen supersaturation were elevated at 190 (%) saturation (15.9 mg O2 l-1) and the highest biochemical oxygen demand associated with the bloom was greater than 25 mg O2 l-1. Using biovolume data to calculate carbon content, and a water exchange rate of 0.06 d-1 and dilution factor of 0.1, the potential oxygen demand following bloom collapse was estimated to be 7.22 mg O2 l-1. The potential impact of this thin layer on the water quality of the estuary is discussed.

  12. Cephalopod-INspired Adaptive Photonic SystEms (CINAPSE)

    Science.gov (United States)

    2013-09-13

    Andrew Magyar , Evelyn Hu Patents Awarded Awards David Awschalom: David Turnbull Award, Materials Research Society (2010), election to National Academy of...Equivalent: 4Total Number: Names of Post Doctorates PERCENT_SUPPORTEDNAME Igor Aharonovich, Harvard 0.00 Andrew Magyar , Harvard 1.00 Lee Bassett, UCSB...contracting officer? (5e) N Foreign Countries of application (5g-2): 5 Leila Deravi, Kevin Kit Parker, Andrew Magyar , Evelyn Hu Harvard University 29 Oxford

  13. Lightcurve Results for 1318 Nerina, 222 Lermontov 3015 Candy, 3089 Oujianquan, 3155 Lee, 6410 Fujiwara, 6500 Kodaira, (8290) 1992 NP, 9566 Rykhlova, (42923) 1999 SR18, and 2001 FY

    Science.gov (United States)

    Clark, Maurice

    2007-03-01

    Lightcurve period and amplitude results for 10 minor planets are presented. The observations were made at 3 locations: the Montgomery College Observatory, Chiro Observatory, and the Rosemary Hill Observatory. (1318) Nerina: 2.536 ± 0.001 hr, 0.16 ± 0.02 mag. (2222) Lermontov: 4.344 ± 0.001 hr, 0.58 ± 0.01 mag. (3015) Candy: 4.265 ± 0.001 hr, 1.05 ± 0.01 mag. (3089) Oujianquan: 11.198 ± 0.003 hr, 0.45 ± 0.05 mag. (3155) Lee: 8.36 ± 0.01 hr, 0.4 ± 0.1 mag. (6410) Fujiwara: 7.008 ± 0.001 hr, 0.80 ± 0.02 mag. (6500) Kodaira: 5.496 ± 0.009 hr, 0.80 ± 0.02 mag. (8290) 1992 NP: 4.453 ± 0.001 hr, 0.58 ± 0.02 mag. (9566) Rykhlova: 8.800 ± 0.001 hr, 0.95 ± 0.02 mag. (42923) 1999 SR18: 8.392 ± 0.001 hr, 1.38 ± 0.05 mag. 2001 FY: 5.207 ± 0.005 hr, 0.45 ± 0.05 mag. Also reported are indefinite period results for four objects in the hope that they may be useful for future observers: 1110 Jaroslawa, 1720 Neils, 3872 Akirafuji, and 6790 Pingouin.

  14. Inglased puhkavad Haljalas toodetud patjadel / Merike Lees

    Index Scriptorium Estoniae

    Lees, Merike, 1976-

    2005-01-01

    TOP-i 1. koht. Ülevaade Briti perefirma filiaali, patju ja tekke valmistava Baltic Fibres OÜ tegevusest. Kommenteerib Haljala vallavanem Jüri Sikkut. Lisa: Baltic Fibres OÜ. Diagramm: Kasum 15 miljonit suurem kui mullu

  15. Uued elamupiirkonnad / Lee Taal, Gea Velthut

    Index Scriptorium Estoniae

    Taal, Lee

    1998-01-01

    Lühiinfot: projektijuht, valmis elamud, infrastruktuur, arhitektuurne kontseptsioon, ehitajad, arhitektid jm. Maarjamäe elamupiirkond (AB Harmin, AB Urbel ja Peil, Alver Trummal Arhitektid), Vabaõhukooli tee asum (Künnapu & Padrik), Lepiku küla Kloostrimetsas /Lepiku Kinnisvarahooldus), Raudalu asum Viljandi mnt. ääres (R-Konsult, I. Raud), Kodu 2001 (Nordprojekt, Jaak Kruusmägi), Tiskre Haaberstis (Arhitektuuribüroo Alis), Randvere tee (Nordprojekt), Veskimöldre (Koot ja Koot).

  16. Kahanev rahvaarv kasvatab rahumeelsust / Lee Kuan Yew

    Index Scriptorium Estoniae

    Lee Kuan Yew, 1923-

    2013-01-01

    Singapuri kauaaegne peaminister meenutab, et teise maailmasõja ajendiks oli Jaapani ja Saksamaa kõrgest sündimuskordajast (vastavalt 4,2 ja 2,6) tingitud ruumipuudus ja laienemisiha. Arvestades India (2,6) ja Aafrika riikide (4-7) vastavaid arve, küsib autor, mis meid nüüd ees ootab ja kas oleme selleks valmis

  17. FLOODPLAIN, LEE COUNTY, GEORGIA and INCORPORATED AREAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  18. Lee Kuan Yew: Master Builder of Singapore

    National Research Council Canada - National Science Library

    Exner, Philip J

    1996-01-01

    .... Few, however, have independence forced upon them as Singapore did. On August 9, 1965, after several stormy years attempting to integrate in a post-colonial federation, it was unexpectedly expelled from Malaysia...

  19. ' "Life is Movement": Vernon Lee and Sculpture'

    DEFF Research Database (Denmark)

    Østermark-Johansen, Lene

    2018-01-01

    How do living, breathing human bodies respond to the inert bodies of sculpture? This article examines some of the art-theoretical and psychological writings of Violet Paget (‘Vernon Lee’) and Clementina Anstruther-Thomson of the 1880s and 1890s in an attempt to map the evolution of their formalist...... from Lee’s early essays in Belcaro: Being Essays on Sundry Aesthetical Questions (1881) to the late collaborative volume Art and Man (1924)....

  20. Jaapani edumetoodika ka Eestis / Merike Lees

    Index Scriptorium Estoniae

    Lees, Merike, 1976-

    2004-01-01

    Ilmunud ka: Delovõje Vedomosti 17. nov. lk. 28. Tootmissfääris kasutatavast Jaapani 20 võtme metoodikast loodab ettevõttele kasu saada lehtmetalli töötleva AS-i Favor Metaform nõukogu esimees Almar Proosi. Lisa: Mis on 20 võtit?

  1. DCS Terrain Submission for Lee County MS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix M: Data Capture Standards, describes the digital topographic data that was used to create...

  2. Floodplain Submission for Lee County, MS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  3. THE POLITICAL CRITIQUE OF SPIKE Lee's Bamboozled

    African Journals Online (AJOL)

    Admin

    INTRODUCTION Because slavery is the founding historical relationship between black and white in America many will argue, lingers in subterranean form to this day (Guerrero 1993: 03). Film and the African-American Image. As a form of ..... memory in modern cultural life” (01). Film becomes a cultural tool bearing popular ...

  4. Lee Kuan Yew: Master Builder of Singapore

    National Research Council Canada - National Science Library

    Exner, Philip J

    1996-01-01

    ... powerhouse has made the "Singapore Model" one of the most closely studied patterns among developing nations. Singapore enjoyed sustained growth and political stability during a period when other regional states experienced much turbulence...

  5. Lees- en spellingagterstande van leerders met serebrale ...

    African Journals Online (AJOL)

    The causes and characteristics of the reading and spelling deficits of learners with cerebral palsy (CP), as well as the working memory processing are discussed. Due to the vision, hearing and speech disabilities of these learners, the phonological loop in the working memory receives and rejects an unclear message, ...

  6. Lahinguväljalt ärikooli / Jane Porter

    Index Scriptorium Estoniae

    Porter, Jane

    2008-01-01

    Ameerikas tsiviilellu naasnud sõjaväelaste üha populaarsemaks muutunud otsusest asuda õppima ärikoolidesse. Sõjaväelise taustaga õppuritest on huvitatud ka nii ärikoolid kui ettevõtted, kuna nad on distsiplineeritud ja omavad juhtimiskogemust

  7. Stories of Transition From G. I. Joe, G. I. Jane

    Directory of Open Access Journals (Sweden)

    Nguyenvoges Shelbee R.

    2015-08-01

    Full Text Available The purpose of this case study research aims to bridge gaps in the current research by exploring how both veteran and nonveteran adult and higher education (AHE learners make sense of their educational journey and identity, in and out of the classroom, during their first-year experience (FYE course at a community college (CC in the Southwest region. Combining critical incident technique (CIT and narrative inquiry, the researcher is able to investigate veteran and nonveteran AHE learners’ personal critical incident narrative testimonies to make sense of individual identity and values. Relevant literature on the topic of FYE’s and transition for veteran and nonveteran learners underscore potentially problematic issues in the current scholarship. The theoretical framework from which this research was undertaken, methodology, findings and discussion reveal how nonveteran and veteran AHE learners identify a ‘third side’ or common ground in 1 the fight to pursue AHE, 2 the negotiation of new roles and 3 the influence of family on identity. To conclude, implications for future research and conclusions to advance understandings about veteran AHE learners have been offered. Ultimately, participant responses reveal common or ‘third sides,’ and how these ‘third side’ spaces contribute towards a collaborative learning environment in an FYE. General experiences of transition into the higher education setting for veteran and nonveteran learners are also shared in the findings.

  8. "Me Tarzan, You Jane!" Adequacy, Expressiveness, and the Creole Speaker.

    Science.gov (United States)

    Rickford, John R.

    1986-01-01

    Argues that the adequacy of pidgins and creoles as expressive instruments requires systematic empirical research. This research would be based on two sound approaches: a macro-survey of language resources and a micro-analysis of language samples. (CB)

  9. Moi Tarzan, Vous Jane?: A Study of Communicative Competence

    Science.gov (United States)

    Powell, Patricia B.

    1975-01-01

    Secondary students of French interviewed a researcher posing as a French speaker. Error patterns and structures used were analyzed. Many errors were apparently due to interference; many others were apparently the result of reduction processes. Results suggested that errors might be corrected in terms of comprehensibility to a native speaker.…

  10. 233 Meaning and the Second Language Learner Jane Nkechi ...

    African Journals Online (AJOL)

    Ike Odimegwu

    the mind of anyone who knows and understands the expression. Sapir also explains meanings in terms of concepts. He sees concept as a “capsule of thought” containing many distinct experiences (Lobner 162). For. Saussure, meaning is to be understood in the context of signs in general. This theory emphasizes that it is a.

  11. How Johnny/Jane Writes: The Complex Word.

    Science.gov (United States)

    Keller, Rodney D.

    The process of getting a thought out of the mind and onto paper can be divided into five major categories: (1) discovering the word, (2) excavating the mythic word from the subconscious, (3) perceiving the word in the conscious, (4) verbalizing the expressed word, and (5) comprehending the unsaid word. When humans experience anything, their minds…

  12. Eesti rahvusbibliograafia andmebaas on iseseisev andmekogu / Jane Makke

    Index Scriptorium Estoniae

    Makke, Jane, 1976-

    2015-01-01

    Eesti rahvusbibliograafia andmebaasi (http://erb.nlib.ee) koostamisest, kasutamisest, pakutavatest uutest otsivõimalustest ning ees ootavatest uuendustest. Analüüsitud on ka ERB-i kasutamist ja tutvustatud statistika uuendusi

  13. CODE SWITCHING: A VARIATION IN LANGUAGE USE. Jane ...

    African Journals Online (AJOL)

    MISS NWOBU

    languages in contact and this produces such linguistic results as multilingualism, bilingualism, code-switching, code-mixing, alternation, inference, borrowings etc. Human activities are much varied and each activity according to audience, purpose, occasion or time of the day is usually accompanied by variations in speech ...

  14. Male Nurses: More Like John Doe Than Jane Doe.

    Science.gov (United States)

    McCutcheon, Lynn E.

    A study of 66 female and 56 male nurses employed in central Florida investigated the relationship between nursing experience and sex-role orientation and values. Nursing experience and degrees were similarly distributed across genders in the sample of nurses. The Bem Sex Role Inventory, a checklist of stereotypically feminine and masculine…

  15. Jane Bowles: DAN NA OTVORENOM / S engleskog prevela Vivijana Radman

    Directory of Open Access Journals (Sweden)

    Jane Bowles

    2012-06-01

    Full Text Available Na periferiji glavnog grada stajala je niska bijela kuća, veoma nalik kućama koje su je okruživale. Ulica u kojoj se nalazila nije bila popločana zato što je to bila siromašna četvrt. Vrata te kuće, posve nova i ukrašena čavlima, bila su zakračunata i s unutarnje i s vanjske strane. Velika soba, opremljena s nekoliko modernih kromiranih stolica, barom i džuboksom otvarala se na prazno unutarnje dvorište. Na jednoj od tih stolica sjedio je debeo dječačić Indijanac i slušao Good Night, Sweetheart, pjesmu koju je netom odabrao. Svirala je vrlo glasno, a dječačić je ozbiljno zurio u stroj pred sobom. Bila je to jedna od kuća kojima je upravljao njihov vlasnik, senor Kurten, napola Španjolac, napola Nijemac. Poslijepodne je bilo tmurno. U jednoj od soba upravo su se probudile Julia i Inez. Julia je bila sitna i nalik majmunčiću. Bila je privlačna samo zbog svojih neobično velikih i sjajnih očiju. Inez je bila visoka, čvrstih grudiju. Glava joj je bila premalena za tijelo, a oči suviše blizu. Kosu je nosila ukrućenu u valove.

  16. Jane f. Kelly and catherine l. Ward Department of Psychology ...

    African Journals Online (AJOL)

    Journal of Child and. Family Studies, 19, 360-378. Todis, B., Bullis, M., Waintrup, M., Schultz,. R., & D'Ambrosio, R. (2001). Overcom- ing the odds: Qualitative examination of resilience among formerly incarcerated adolescents. Exceptional Children, 68,. 119-139. Ungar, M. (2008). Resilience across cultures. British Journal ...

  17. Technically Speaking: Columns from the Monthly Magazine, "The Source," 1987-88. Trace Reprint Series.

    Science.gov (United States)

    Borden, Peter A.; And Others

    The "Technically Speaking" columns from several isues of "The Source" magazine are reprinted. The columns were written by Gregg Vanderheiden, Peter Borden, Roger Smith, Jane Berliss, and Charles Lee. Titles of the columns included are: "Technological Advances: A Boon or a Barrier to Persons with Disabilities?";…

  18. Abielluda! Abielluda! Abielluda! / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017

    2008-01-01

    Lühiarvustus Jane Austeni romaani ekraniseeringule "Mõistus ja tunded" ("Sens and Sensibility") : stsenarist Emma Thompson : režissöör Ang Lee : Suurbritannia - Ameerika Ühendriigid 1995. Lisatud andmed režissööri kohta

  19. Definition and display of steric, hydrophobic, and hydrogen-bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: validation of a high-resolution graphical tool for drug design.

    Science.gov (United States)

    Bohacek, R S; McMartin, C

    1992-05-15

    The accessible surface, described by Lee and Richards (the L&R surface: J. Mol. Biol. 1971, 55, 379), has remarkably useful properties for displaying ligand-protein interactions. The surface is placed one van der Waals radius plus one probe radius away from the protein atoms. The ligands are displayed in skeletal form. With a suitable probe radius, those parts of the ligand in good van der Waals contact with the protein binding site are found superimposed on the L&R surface. Display of the surface using parallel contours therefore provides a very powerful guide for interactive drug design because only ligand atoms lying on or close to the surface are in low-energy contact. The ability of the surface to accurately display steric complementarity between ligands and proteins was optimized using data from small molecule crystal structures. The possibility of displaying the chemical specificity of the binding site was also investigated. The surface can be colored to give precise information about chemical specificity. Electrostatic potential, electrostatic gradient, and distance to hydrogen-bonding groups were tested as methods of displaying chemical specificity. The ability of these methods to describe the complementarity actually observed in the interior of proteins was compared. High-resolution crystal data for ribonuclease and trypsin was used. The environment surrounding extended peptide chains in the protein was treated as a virtual binding site. The peptide chain served as a virtual ligand. This large sample of experimental data was used to measure the correlation between type of ligand atom and the calculated property of the nearest binding site surface. The best correlation was obtained using hydrogen-bonding properties of the binding site. Using this parameter the surface could be divided into three separate zones representing the hydrophobic, hydrogen-bond-acceptor, and hydrogen-bond-donor properties of the binding site. The percentage of hydrophobic ligand

  20. Harvard--MIT research program in short-lived radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    1991-03-01

    This report describes progress on five projects. The first project showed a 1000 fold concentration of the cationic complex {sup 99m}Tc (MIBI) in heart cell mitochondria vs heart cell cytoplasm, as determined by high resolution electron probe microanalysis. Additional technetium-99m based complexes are being developed and tested. The second project involves evaluating technetium acetylacteonates as potential indicators of cerebral blood flow. An intermediate in the synthesis of a technetium porphyrin complex has been synthesized; an oxotechnetium(V)-2,4-pentanedione complex has been prepared and is currently being characterized. The third project involves using radio labelled antibodies for diagnosis and treatment of cancer. An early discovery was that chloramine-T based iodination protocols resulted in a reversal of the charge on mouse lgGs. Immunoperoxidase-labelled monoclonal antibody MOv 18 was shown to bind specifically to the most frequent ovarian aderon carcinomas, and not to healthy tissue, making this antibody a good candidate for immunotherapy or immunodetection. Work on a specific immunotherapy protocol suffered a setback when one reagent, a {sup 125}I-biotin complex, proved to be unstable in vivo. The fourth project involves labelling antibodies with positron emitting radionuclides. Radiofluorination was accomplished through reductive alkylation of {sup 18}F-aldehyde, or pentafluorophenyl esters. Radioiodination was accomplished using alkyl-tin derivation exchange. The fifth project examined antibody modification for use in radioimmune imaging. Technetium-99m-labelled lgG was shown to be biologically equivalent to Indium-III-labelled lgG for imaging focal sites of inflamation. Also, Indium III labelling of small bioactive peptides was examined as a means of imaging important physiological processes. 44 refs., 2 figs.