Reconstituted TOM core complex and Tim9/Tim10 complex of mitochondria are sufficient for translocation of the ADP/ATP carrier across membranes.

Science.gov (United States)

Vasiljev, Andreja; Ahting, Uwe; Nargang, Frank E; Go, Nancy E; Habib, Shukry J; Kozany, Christian; Panneels, Valérie; Sinning, Irmgard; Prokisch, Holger; Neupert, Walter; Nussberger, Stephan; Rapaport, Doron

2004-03-01

Precursor proteins of the solute carrier family and of channel forming Tim components are imported into mitochondria in two main steps. First, they are translocated through the TOM complex in the outer membrane, a process assisted by the Tim9/Tim10 complex. They are passed on to the TIM22 complex, which facilitates their insertion into the inner membrane. In the present study, we have analyzed the function of the Tim9/Tim10 complex in the translocation of substrates across the outer membrane of mitochondria. The purified TOM core complex was reconstituted into lipid vesicles in which purified Tim9/Tim10 complex was entrapped. The precursor of the ADP/ATP carrier (AAC) was found to be translocated across the membrane of such lipid vesicles. Thus, these components are sufficient for translocation of AAC precursor across the outer membrane. Peptide libraries covering various substrate proteins were used to identify segments that are bound by Tim9/Tim10 complex upon translocation through the TOM complex. The patterns of binding sites on the substrate proteins suggest a mechanism by which portions of membrane-spanning segments together with flanking hydrophilic segments are recognized and bound by the Tim9/Tim10 complex as they emerge from the TOM complex into the intermembrane space.

TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection.

Science.gov (United States)

Wang, Jing; Qiao, Luhua; Hou, Zhouhua; Luo, Guangxiang

2017-01-15

Human TIM and TAM family proteins were recently found to serve as phosphatidylserine (PS) receptors which promote infections by many different viruses, including dengue virus, West Nile virus, Ebola virus, Marburg virus, and Zika virus. In the present study, we provide substantial evidence demonstrating that TIM-1 is important for efficient infection by hepatitis C virus (HCV). The knockdown of TIM-1 expression significantly reduced HCV infection but not HCV RNA replication. Likewise, TIM-1 knockout in Huh-7.5 cells remarkably lowered HCV cell attachment and subsequent HCV infection. More significantly, the impairment of HCV infection in the TIM-1 knockout cells could be restored completely by ectopic expression of TIM-1 but not TIM-3 or TIM-4. Additionally, HCV infection and cell attachment were inhibited by PS but not by phosphatidylcholine (PC), demonstrating that TIM-1-mediated enhancement of HCV infection is PS dependent. The exposure of PS on the HCV envelope was confirmed by immunoprecipitation of HCV particles with a PS-specific monoclonal antibody. Collectively, these findings demonstrate that TIM-1 promotes HCV infection by serving as an attachment receptor for binding to PS exposed on the HCV envelope. TIM family proteins were recently found to enhance infections by many different viruses, including several members of the Flaviviridae family. However, their importance in HCV infection has not previously been examined experimentally. The TIM family proteins include three members in humans: TIM-1, TIM-3, and TIM-4. The findings derived from our studies demonstrate that TIM-1, but not TIM-3 or TIM-4, promotes HCV infection by functioning as an HCV attachment factor. Knockout of the TIM-1 gene resulted in a remarkable reduction of HCV cell attachment and infection. PS-containing liposomes blocked HCV cell attachment and subsequent HCV infection. HCV particles could also be precipitated with a PS-specific monoclonal antibody. These findings suggest that TIM-1

There are those who call it...TIM

CERN Multimedia

2007-01-01

To boldly go where people can't... The Train Inspection Monorail, affectionately referred to as 'TIM,' will allow scientists, technicians and engineers to view and take measurements in the LHC tunnel when it is inaccessible to humans. TIM in the tunnel.Jean-Louis Grenard, who designed TIM's mechanical components, uses the portable remote control station to put the TIM through its paces at Point 1 in the LHC. Imagine being able to view parts of the LHC before people are allowed into the tunnel after the beam has been circulating...or to accurately measure the position of equipment in areas with the highest levels of radiation without risking human exposure. The Train Inspection Monorail, or 'TIM' to its closer friends, is a modular train that will run along the ceiling of the LHC tunnel, helping many groups on site to address the problems of inspecting, measuring and even handling equipment in the LHC when radiation levels and cryogenic hazards will restrict personnel access to the tunnel. TIM was developed ...

Tim Berners-Lee during the WSIS

CERN Multimedia

Maximilien Brice

2003-01-01

Tim Berners-Lee stands in front of the first web server at the Geneva Palexpo during the World Summit on the Information Society (WSIS) in 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

TIM-1 signaling in B cells regulates antibody production

International Nuclear Information System (INIS)

Ma, Juan; Usui, Yoshihiko; Takeda, Kazuyoshi; Harada, Norihiro; Yagita, Hideo; Okumura, Ko; Akiba, Hisaya

2011-01-01

Highlights: → TIM-1 is highly expressed on anti-IgM + anti-CD40-stimulated B cells. → Anti-TIM-1 mAb enhanced proliferation and Ig production on activated B cell in vitro. → TIM-1 signaling regulates Ab production by response to TI-2 and TD antigens in vivo. -- Abstract: Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other hand, TIM-1 ligand was constitutively expressed on B cells and inducible on anti-CD3 + anti-CD28-stimulated CD4 + T cells. In vitro stimulation of activated B cells by anti-TIM-1 mAb enhanced proliferation and expression of a plasma cell marker syndecan-1 (CD138). We further examined the effect of TIM-1 signaling on antibody production in vitro and in vivo. Higher levels of IgG2b and IgG3 secretion were detected in the culture supernatants of the anti-TIM-1-stimulated B cells as compared with the control IgG-stimulated B cells. When immunized with T-independent antigen TNP-Ficoll, TNP-specific IgG1, IgG2b, and IgG3 Abs were slightly increased in the anti-TIM-1-treated mice. When immunized with T-dependent antigen OVA, serum levels of OVA-specific IgG2b, IgG3, and IgE Abs were significantly increased in the anti-TIM-1-treated mice as compared with the control IgG-treated mice. These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation.

TIM-1 signaling in B cells regulates antibody production

Energy Technology Data Exchange (ETDEWEB)

Ma, Juan [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Usui, Yoshihiko [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku-ku, Tokyo 160-0023 (Japan); Takeda, Kazuyoshi [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Harada, Norihiro [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Department of Respiratory Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Research Institute for Diseases of Old Ages, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Yagita, Hideo; Okumura, Ko [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Akiba, Hisaya, E-mail: hisaya@juntendo.ac.jp [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan)

2011-03-11

Highlights: {yields} TIM-1 is highly expressed on anti-IgM + anti-CD40-stimulated B cells. {yields} Anti-TIM-1 mAb enhanced proliferation and Ig production on activated B cell in vitro. {yields} TIM-1 signaling regulates Ab production by response to TI-2 and TD antigens in vivo. -- Abstract: Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other hand, TIM-1 ligand was constitutively expressed on B cells and inducible on anti-CD3{sup +} anti-CD28-stimulated CD4{sup +} T cells. In vitro stimulation of activated B cells by anti-TIM-1 mAb enhanced proliferation and expression of a plasma cell marker syndecan-1 (CD138). We further examined the effect of TIM-1 signaling on antibody production in vitro and in vivo. Higher levels of IgG2b and IgG3 secretion were detected in the culture supernatants of the anti-TIM-1-stimulated B cells as compared with the control IgG-stimulated B cells. When immunized with T-independent antigen TNP-Ficoll, TNP-specific IgG1, IgG2b, and IgG3 Abs were slightly increased in the anti-TIM-1-treated mice. When immunized with T-dependent antigen OVA, serum levels of OVA-specific IgG2b, IgG3, and IgE Abs were significantly increased in the anti-TIM-1-treated mice as compared with the control IgG-treated mice. These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation.

Characterizing Functional Domains for TIM-Mediated Enveloped Virus Entry

Science.gov (United States)

Moller-Tank, Sven; Albritton, Lorraine M.; Rennert, Paul D.

2014-01-01

ABSTRACT T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance entry of Ebola virus (EBOV) and other viruses by binding PtdSer on the viral envelope, concentrating virus on the cell surface, and promoting subsequent internalization. The PtdSer-binding activity of the immunoglobulin-like variable (IgV) domain is essential for both virus binding and internalization by TIM-1. However, TIM-3, whose IgV domain also binds PtdSer, does not effectively enhance virus entry, indicating that other domains of TIM proteins are functionally important. Here, we investigate the domains supporting enhancement of enveloped virus entry, thereby defining the features necessary for a functional PVEER. Using a variety of chimeras and deletion mutants, we found that in addition to a functional PtdSer-binding domain PVEERs require a stalk domain of sufficient length, containing sequences that promote an extended structure. Neither the cytoplasmic nor the transmembrane domain of TIM-1 is essential for enhancing virus entry, provided the protein is still plasma membrane bound. Based on these defined characteristics, we generated a mimic lacking TIM sequences and composed of annexin V, the mucin-like domain of α-dystroglycan, and a glycophosphatidylinositol anchor that functioned as a PVEER to enhance transduction of virions displaying Ebola, Chikungunya, Ross River, or Sindbis virus glycoproteins. This identification of the key features necessary for PtdSer-mediated enhancement of virus entry provides a basis for more effective recognition of unknown PVEERs. IMPORTANCE T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members are recently identified phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance virus entry by binding the phospholipid, PtdSer, present on the viral

Tim Berners-Lee receives the Millennium Technology Prize

CERN Multimedia

2004-01-01

On 15 April, for his invention of the Web, Tim Berners-Lee was awarded the first ever Millennium Technology Prize by the Finnish Technology Award Foundation, which recognises technological innovations of lasting benefit to society. "Tim Berners-Lee's invention perfectly encapsulates the spirit of the Prize. The Web is encouraging new types of social networks, contributing to transparency and democracy, and opening up new avenues for information management and business development," underlined Pekka Tarjanne, chairman of the jury and former Secretary-General of the International Telecommunication Union (ITU). Tim Berners-Lee is congratulated by Jukka Valtasaari, Finland's Ambassador to the United States. Tim Berners-Lee created the first server, browser and editor, the HTML code, the URL address and the HTTP transmission protocol at CERN in 1990. CERN released the Web into the public domain in 1993. Tim Berners-Lee is currently head of the World Wide Web Consortium, managed by ERCIM (Europe...

Preliminary crystallographic studies of yeast mitochondrial peripheral membrane protein Tim44p

Energy Technology Data Exchange (ETDEWEB)

Josyula, Ratnakar [Department of Cell Biology, Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States); Jin, Zhongmin [SER-CAT, APS, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); McCombs, Deborah; DeLucas, Lawrence [Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States); Sha, Bingdong, E-mail: bdsha@uab.edu [Department of Cell Biology, Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States)

2006-02-01

Tim44p is an essential mitochondrial peripheral membrane protein. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, the yeast Tim44p has been crystallized. Protein translocations across mitochondrial membranes play critical roles in mitochondrion biogenesis. Protein transport from the cell cytosol to the mitochondrial matrix is carried out by the translocase of the outer membrane (TOM) complex and the translocase of the inner membrane (TIM) complexes. Tim44p is an essential mitochondrial peripheral membrane protein and a major component of the TIM23 translocon. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, the yeast Tim44p was crystallized. The crystals diffract to 3.2 Å using a synchrotron X-ray source and belong to space group P6{sub 3}22, with unit-cell parameters a = 124.25, c = 77.83 Å. There is one Tim44p molecule in one asymmetric unit, which corresponds to a solvent content of approximately 43%. Structure determination by MAD methods is under way.

Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry

Science.gov (United States)

Moller-Tank, Sven; Kondratowicz, Andrew S.; Davey, Robert A.; Rennert, Paul D.

2013-01-01

The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola virus (EBOV) entry through direct interaction with PtdSer on the viral envelope. PtdSer liposomes but not phosphatidylcholine liposomes competed with TIM-1 for EBOV pseudovirion binding and transduction. Further, annexin V (AnxV) substituted for the TIM-1 IgV domain, supporting a PtdSer-dependent mechanism. Our findings suggest that TIM-1-dependent uptake of EBOV occurs by apoptotic mimicry. Additionally, TIM-1 enhanced infection of a wide range of enveloped viruses, including alphaviruses and a baculovirus. As further evidence of the critical role of enveloped-virion-associated PtdSer in TIM-1-mediated uptake, TIM-1 enhanced internalization of pseudovirions and virus-like proteins (VLPs) lacking a glycoprotein, providing evidence that TIM-1 and PtdSer-binding receptors can mediate virus uptake independent of a glycoprotein. These results provide evidence for a broad role of TIM-1 as a PtdSer-binding receptor that mediates enveloped-virus uptake. Utilization of PtdSer-binding receptors may explain the wide tropism of many of these viruses and provide new avenues for controlling their virulence. PMID:23698310

Rama, Prof.

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1969 Section: Earth & Planetary Sciences. Rama, Prof. Ph.D. (Mumbai), FNA, FNAAS. Date of birth: 16 March 1929. Specialization: Isotope Hydrology Address: Y-4, Sector 9, CBD, Navi Mumbai 400 614, Maharashtra Contact: Residence: (022) 2757 0081. Email: rama.506@yahoo.

Kundu, Prof. Manikuntala

Indian Academy of Sciences (India)

, Prof. Manikuntala Ph.D. (Calcutta). Date of birth: 17 March 1958. Specialization: Stress Response in Mycobacterium Tuberculosis, Immunology of Host Cell Response to Helicobacter Pylori Address: Senior Professor, Department of Chemistry ...

Balakrishnan, Prof. Narayanaswamy

Indian Academy of Sciences (India)

Elected: 1994 Section: Engineering & Technology. Balakrishnan, Prof. Narayanaswamy Ph.D. (IISc), FNAE, FNA, FNASc, FTWAS ... Specialization: Numerical Electromagnetics, Information Security, Complex Networks, and Aerospace Electronic Systems Address: SERC, Indian Institute of Science, Bengaluru 560 012, ...

Highlights lecture EANM 2014: ''Gimme gimme gimme those nuclear Super Troupers''

Energy Technology Data Exchange (ETDEWEB)

Jong, Marion de [Erasmus MC Rotterdam, Departments of Nuclear Medicine and Radiology, Rotterdam (Netherlands); Laere, Koen van [University Hospital and KU Leuven, Division of Nuclear Medicine, Department of Imaging and Pathology, Leuven (Belgium)

2015-04-01

The EANM Congress 2014 took place in Gothenburg, Sweden, from 18 to 22 October under the presidency of Prof. Wim Oyen, chair of the EANM Scientific Committee. Prof. Peter Gjertsson chaired the Local Organizing Committee, according to the standardized EANM congress structure. The meeting was a highlight for the multidisciplinary community that forms the heart and soul of nuclear medicine; attendance was exceptionally high. In total almost 5,300 participants came to Gothenburg, and 1,397 colleagues participated via the EANM LIVE sessions (http://eanmlive.eanm.org/index.php). Participants from all continents were presented with an excellent programme consisting of symposia, scientific and featured sessions, CME sessions, and plenary lectures. These lectures were devoted to nuclear medicine therapy, hybrid imaging and molecular life sciences. Two tracks were included in the main programme, clustering multi-committee involvement: the 5th International Symposium on Targeted Radionuclide-therapy and Dosimetry (ISTARD) and the first Molecules to Man (M2M) track, an initiative of the EANM Committees for Translational Molecular Imaging, Radiopharmacy and Drug Development. The industry made a substantial contribution to the success of the congress demonstrating the latest technology and innovations in the field. During the closing Highlights Lecture, a selection of the best-rated abstracts was presented including diverse areas of nuclear medicine: physics and instrumentation, radiopharmacy, preclinical imaging, oncology (with a focus on the clinical application of newly developed tracers) and radionuclide therapy, cardiology and neurosciences. This Highlights Lecture could only be a brief summary of the large amount of data presented and discussed during the meeting, which can be found in much greater detail in the congress proceedings book, published as Volume 41, Supplement 2 of the European Journal of Nuclear Medicine and Molecular Imaging in October 2014. (orig.)

Highlights lecture EANM 2014: ''Gimme gimme gimme those nuclear Super Troupers''

International Nuclear Information System (INIS)

Jong, Marion de; Laere, Koen van

2015-01-01

The EANM Congress 2014 took place in Gothenburg, Sweden, from 18 to 22 October under the presidency of Prof. Wim Oyen, chair of the EANM Scientific Committee. Prof. Peter Gjertsson chaired the Local Organizing Committee, according to the standardized EANM congress structure. The meeting was a highlight for the multidisciplinary community that forms the heart and soul of nuclear medicine; attendance was exceptionally high. In total almost 5,300 participants came to Gothenburg, and 1,397 colleagues participated via the EANM LIVE sessions (http://eanmlive.eanm.org/index.php). Participants from all continents were presented with an excellent programme consisting of symposia, scientific and featured sessions, CME sessions, and plenary lectures. These lectures were devoted to nuclear medicine therapy, hybrid imaging and molecular life sciences. Two tracks were included in the main programme, clustering multi-committee involvement: the 5th International Symposium on Targeted Radionuclide-therapy and Dosimetry (ISTARD) and the first Molecules to Man (M2M) track, an initiative of the EANM Committees for Translational Molecular Imaging, Radiopharmacy and Drug Development. The industry made a substantial contribution to the success of the congress demonstrating the latest technology and innovations in the field. During the closing Highlights Lecture, a selection of the best-rated abstracts was presented including diverse areas of nuclear medicine: physics and instrumentation, radiopharmacy, preclinical imaging, oncology (with a focus on the clinical application of newly developed tracers) and radionuclide therapy, cardiology and neurosciences. This Highlights Lecture could only be a brief summary of the large amount of data presented and discussed during the meeting, which can be found in much greater detail in the congress proceedings book, published as Volume 41, Supplement 2 of the European Journal of Nuclear Medicine and Molecular Imaging in October 2014. (orig.)

Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer

Science.gov (United States)

Gao, Quanli; Yuan, Peng; Zhao, Peng; Yuan, Huijuan; Fan, Huijie; Li, Tiepeng; Qin, Peng; Han, Lu; Fang, Weijia; Suo, Zhenhe

2015-01-01

T-cell exhaustion represents a progressive loss of T-cell function. The inhibitory receptor PD-1 is known to negatively regulate CD8+ T cell responses directed against tumor antigen, but the blockades of PD-1 pathway didn't show the objective responses in patients with colorectal cancer (CRC). Thus, further exploring the molecular mechanism responsible for inducing T-cell dysfunction in CRC patients may reveal effective strategies for immune therapy. This study aims to characterize co-inhibitory receptors on T cells in CRC patients to identify novel targets for immunotherapy. In this study, peripheral blood samples from 20 healthy controls and 54 consented CRC patients, and tumor and matched paraneoplastic tissues from 7 patients with advanced CRC, subjected to multicolor flow cytometric analysis of the expression of PD-1 and Tim-3 receptors on CD8+ T cells. It was found that CRC patients presented with significantly higher levels of circulating Tim-3+PD-1+CD8+ T cells compared to the healthy controls (medians of 3.12% and 1.99%, respectively, p = 0.0403). A similar increase of Tim-3+PD-1+CD8+ T cells was also observed in the tumor tissues compared to paraneoplastic tussues. Tim-3+PD-1+CD8+ T cells in tumor tissues produced even less cytokine than that in paraneoplastic tissues. Functional ex vivo experiments showed that Tim-3+PD-1+CD8+ T cells produced significantly less IFN-γ than Tim-3−PD-1−CD8+ T cells, followed by Tim-3+PD-1−CD8+ T cells, and Tim-3−PD-1+CD8+ T cells, indicating a stronger inhibition of IFN-γ production of Tim-3+CD8+ T cells. It is also found in this study that Tim-3+PD-1+CD8+ T cell increase in circulation was correlated with clinical cancer stage but not histologic grade and serum concentrations of cancer biomarker CEA. Our results indicate that upregulation of the inhibitory receptor Tim-3 may restrict T cell responses in CRC patients, and therefore blockage of Tim-3 and thus restoring T cell responses may be a potential

Gopalakrishnan, Prof. Srinivasan

Indian Academy of Sciences (India)

Elected: 2013 Section: Engineering & Technology. Gopalakrishnan, Prof. Srinivasan Ph.D. (Purdue), FNAE. Date of birth: 25 June 1960. Specialization: Wave Propagation, Structural Health Monitoring, Computational Mechanics Address: Department of Aerospace Engineering, Indian Institute of Science, Bengaluru 560 012, ...

Venkataraman, Prof. Chandra

Indian Academy of Sciences (India)

Elected: 2018 Section: Earth & Planetary Sciences. Venkataraman, Prof. Chandra Ph.D. (Univ. Calif., Los Angeles), FNAE, FNASc. Date of birth: 3 June 1963. Specialization: Aerosol Science & Engineering, Environmental & Climate Science, Atmospheric Science Address: Department of Chemical Engineering, Indian ...

Bajpai, Prof. Sunil

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2007 Section: Earth & Planetary Sciences. Bajpai, Prof. Sunil Ph.D. (Panjab), FNASc. Council Service: 2016-. Date of birth: 30 September 1961. Specialization: Vertebrate Paleontology, Biostratigraphy and Paleobiogeography Address: Director, Birbal Sahni Institute of ...

Balasubramanian, Prof. Ramachandran

Indian Academy of Sciences (India)

Elected: 1987 Section: Mathematical Sciences. Balasubramanian, Prof. Ramachandran Ph.D. (Mumbai), FNA, FNASc. Council Service: 2007-2009. Date of birth: 15 March 1951. Specialization: Analytic Number Theory Address: Professor, The Institute of Mathematical Sciences, CIT Campus, Taramani, Chennai 600 113, ...

Ramachandran, Prof. Janakiraman

Indian Academy of Sciences (India)

Ramachandran, Prof. Janakiraman Ph.D. (UC, Berkeley). Date of birth: 12 June 1935. Specialization: Molecular Biology Address: Chairman, Gangagen Biotechnologies Private Limited, 12, 5th Cross, Raghavendra Layout, Tumkuar Road, Yeshwantpur, Bengaluru 560 022, Karnataka Contact: Office: (080) 4062 1300-328

Jayakrishnan, Prof. Athipettah

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2001 Section: Engineering & Technology. Jayakrishnan, Prof. Athipettah Ph.D. (IIT, Chennai). Date of birth: 25 April 1953. Specialization: Polymer Chemistry, Biomaterials and Controlled Drug Delivery Address: Department of Biotechnology, Indian Institute of Technology, Chennai 600 036, T.N.

Kumar, Prof. Anurag

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2010 Section: Engineering & Technology. Kumar, Prof. Anurag Ph.D. (Cornell), FNA, FNAE, FIEEE, FTWAS. Date of birth: 13 July 1955. Specialization: Wireless Networks, Communication Networks, Stochastic Modelling, Analysis & Optimisation of Distributed Systems Address: Director, Indian Institute ...

Sarkar, Prof. Sabyasachi

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1997 Section: Chemistry. Sarkar, Prof. Sabyasachi Ph.D. (Gorakhpur). Date of birth: 17 May 1947. Specialization: Graphene & Carbon Quantum Dots, Drug Delivery, Bio-geoinorganic Chemistry, Structure-functional analogues of metallo-proteins, Carbon Quantum Dots, Bio- ...

Mittal, Prof. Sanjay

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2007 Section: Engineering & Technology. Mittal, Prof. Sanjay Ph.D. (Minnesota), FNAE, FNA, FNASc. Date of birth: 27 February 1968. Specialization: Unsteady Aerodynamics, Finite Element Analysis, High Performance Computing and Bluff-body Flows, Aerodynamic Shape ...

Govindarajan, Prof. Rama

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2010 Section: Engineering & Technology. Govindarajan, Prof. Rama Ph.D. (IISc), FNASc. Date of birth: 26 August 1962. Specialization: Fluid Mechanics Address: International Centre for Theoretical Science, Shivakote, Hesaraghatta Post, Bengal;uru 560 089, Karnataka Contact:

Ila, Prof. Hiriyakkanavar

Indian Academy of Sciences (India)

Elected: 1991 Section: Chemistry. Ila, Prof. Hiriyakkanavar Ph.D. (IIT, Kanpur), FNA. Date of birth: 11 September 1944. Specialization: Synthetic Organic Chemistry, Heterocyclic Chemistry, Medicinal Chemistry Address: Apt. 002, Block VIII, Heritage Estate, Doddaballapur Road, Yelahanka, Bengaluru 560 064, Karnataka

Sharma, Prof. Shobhona

Indian Academy of Sciences (India)

Sharma, Prof. Shobhona Ph.D. (Mumbai), FNA. Date of birth: 5 February 1953. Specialization: Molecular Parasitology, Parasite Immunology and Parasite Metabolism Address: Senior Professor & Chairperson, Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, ...

Vishveshwara, Prof. Saraswathi

Indian Academy of Sciences (India)

Vishveshwara, Prof. Saraswathi Ph.D. (CUNY), FNASc. Date of birth: 30 April 1946. Specialization: Computational Biology, Molecular Dynamics & Graph Theoretic Approaches to Biomolecular Structure & Function Address: NASI Senior Scientist, Molecular Biophysics Unit, Indian Institute of Science, Bengaluru 560 012, ...

Bansal, Prof. Manju

Indian Academy of Sciences (India)

Bansal, Prof. Manju Ph.D. (IISc), FNASc, FNA. Date of birth: 1 December 1950. Specialization: Computational Structural Biology, Computational Genome Analysis and Biomolecular Modelling Address: INSA Senior Scientist, Molecular Biophysics Unit, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

Kumar, Prof. Lalit

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2010 Section: Medicine. Kumar, Prof. Lalit MD (Agra), DM (Madras), FAMS, FNASc. Council Service: 2016-. Date of birth: 30 June 1957. Specialization: Stem Cell Transplantation, Multiple Myeloma, Haemato-Oncology, Gynaecologic Oncology Address: Head, Department of ...

Balaram, Prof. Hemalatha

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2009 Section: General Biology. Balaram, Prof. Hemalatha Ph.D. (IISc). Date of birth: 27 October 1956. Specialization: Molecular Enzymology, Molecular Parasitology and Protein Engineering Address: Molecular Biology & Genetics Unit, Jawaharlal Nehru Centre for Advanced ...

Dutta, Prof. Pradip

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2012 Section: Engineering & Technology. Dutta, Prof. Pradip Ph.D. (Columbia), FNAE, FNASc, FNA. Date of birth: 2 October 1960. Specialization: Heat Transfer, Energy Studies Address: Department of Mechanical Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

Vijayraghavan, Prof. Usha

Indian Academy of Sciences (India)

Vijayraghavan, Prof. Usha Ph.D. (Caltech), FNA. Date of birth: 25 August 1961. Specialization: Plant Developmental Genetics, Microbial Genetics and Gene Regulation Address: Professor, Microbiology & Cell Biology Department, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: Office: (080) 2360 0168

Surolia, Prof. Namita

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2002 Section: Medicine. Surolia, Prof. Namita Ph.D. (Allahabad), FNASc. Date of birth: 2 April 1953. Specialization: Molecular Parasitology, Biochemistry and Molecular Biology Address: Molecular Biology & Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, ...

Taming dendritic cells with TIM-3: Another immunosuppressive strategy by tumors

Science.gov (United States)

Patel, Jaina; Bozeman, Erica N.; Selvaraj, Periasamy

2013-01-01

The identification of TIM-3 expression on tumor associated dendritic cells (TADCs) provides insight into another aspect of tumor-mediated immunosuppression. The role of TIM-3 has been well characterized on tumor-infiltrating T cells, however its role on TADCs was not previously known. The current paper demonstrated that TIM-3 was predominantly expressed by TADCs and its interaction with the nuclear protein HMGB1 suppressed nucleic acid mediated activation of an effective antitumor immune response. The authors were able to show that TIM-3 interaction with HMGB1 prevented the localization of nucleic acids into endosomal vesicles. Furthermore, chemotherapy was found to be more effective in anti-TIM-3 mAb treated mice or mice depleted of all DCs which indicated that significant role played by TADCs inhibiting tumor regression. Taken together, these findings identify TIM-3 as a potential target for inducing antitumor immunity in conjunction with DNA vaccines and/or immunogenic chemotherapy in clinical settings. PMID:23240746

Chokshi, Prof. Atul Harish

Indian Academy of Sciences (India)

Elected: 2005 Section: Engineering & Technology. Chokshi, Prof. Atul Harish ... Address: Department of Materials Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: ... Upcoming Refresher Courses. Topology

Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.

LENUS (Irish Health Repository)

Vega-Carrascal, Isabel

2012-02-01

The T-cell Ig and mucin domain-containing molecules (TIMs) have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. It has been reported that proinflammatory cytokine dysregulation and neutrophil-dominated inflammation are the main causes of morbidity in cystic fibrosis (CF). However, the role of TIM receptors in CF has not been investigated. In this study, we demonstrated that TIM-3 is constitutively overexpressed in the human CF airway, suggesting a link between CF transmembrane conductance regulator (CFTR) function and TIM-3 expression. Blockade of CFTR function with the CFTR inhibitor-172 induced an upregulation of TIM-3 and its ligand galectin-9 in normal bronchial epithelial cells. We also established that TIM-3 serves as a functional receptor in bronchial epithelial cells, and physiologically relevant concentrations of galectin-9 induced TIM-3 phosphorylation, resulting in increased IL-8 production. In addition, we have demonstrated that both TIM-3 and galectin-9 undergo rapid proteolytic degradation in the CF lung, primarily because of neutrophil elastase and proteinase-3 activity. Our results suggest a novel intrinsic defect that may contribute to the neutrophil-dominated immune response in the CF airways.

Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.

LENUS (Irish Health Repository)

Vega-Carrascal, Isabel

2011-03-01

The T-cell Ig and mucin domain-containing molecules (TIMs) have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. It has been reported that proinflammatory cytokine dysregulation and neutrophil-dominated inflammation are the main causes of morbidity in cystic fibrosis (CF). However, the role of TIM receptors in CF has not been investigated. In this study, we demonstrated that TIM-3 is constitutively overexpressed in the human CF airway, suggesting a link between CF transmembrane conductance regulator (CFTR) function and TIM-3 expression. Blockade of CFTR function with the CFTR inhibitor-172 induced an upregulation of TIM-3 and its ligand galectin-9 in normal bronchial epithelial cells. We also established that TIM-3 serves as a functional receptor in bronchial epithelial cells, and physiologically relevant concentrations of galectin-9 induced TIM-3 phosphorylation, resulting in increased IL-8 production. In addition, we have demonstrated that both TIM-3 and galectin-9 undergo rapid proteolytic degradation in the CF lung, primarily because of neutrophil elastase and proteinase-3 activity. Our results suggest a novel intrinsic defect that may contribute to the neutrophil-dominated immune response in the CF airways.

Gopakumar, Prof. Rajesh

Indian Academy of Sciences (India)

Elected: 2009 Section: Physics. Gopakumar, Prof. Rajesh Ph.D. (Princeton), FNA, FNASc, FTWAS. Date of birth: 14 December 1967. Specialization: Theoretical Physics, Quantum Field Theory and String Theory Address: Director, International Centre for Theoretical Sciences, Shivakote, Hesaraghatta Post, Bengal;uru 560 ...

Panda, Prof. Sudhakar

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2017 Section: Physics. Panda, Prof. Sudhakar Ph.D. (IoP, Bhubaneswar), FNA, FNASc. Date of birth: 23 February 1959. Specialization: High Energy Physics, String Theory, Cosmology, Quantum Field Theory Address: Director, Institute of Physics, Sachivalaya Marg, Bhubaneswar 751 005, Orissa

Sarkar, Prof. Utpal

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2008 Section: Physics. Sarkar, Prof. Utpal Ph.D. (Calcutta), FNA, FNASc. Date of birth: 15 May 1956. Specialization: Particle & Astroparticle Physics Address: Visiting Professor, Indian Institute of Technology, Kharagpur 721 302, W.B.. Contact: Mobile: 98985 86326

Kant, Prof. Rama

Indian Academy of Sciences (India)

Elected: 2015 Section: Chemistry. Kant, Prof. Rama Ph.D. (IISc). Date of birth: 18 January 1963. Specialization: Complex Systems in Electrochemistry & Polymers, Theoretical Chemistry, Nanoelectrochemistry Address: Department of Chemistry, University of Delhi, Delhi 110 007, U.T.. Contact: Office: (011) 2766 6646/188

Prasad, Prof. Rajendra

Indian Academy of Sciences (India)

Elected: 2000 Section: General Biology. Prasad, Prof. Rajendra Ph.D. (Agra), FNASc, FNA. Date of birth: 14 October 1947. Specialization: Membrane Biology, Yeast Genetics & Molecular Biology and Medical Mycology Address: Director, Amity Institute of Biotechnology, Amity University, Amity Education Valley, Gurgaon 122 ...

Bose, Prof. Indrani

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2000 Section: Physics. Bose, Prof. Indrani Ph.D. (Calcutta), FNASc. Date of birth: 15 August 1951. Specialization: Theoretical Condensed Matter Physics, Statistical Physics, Biological Physics and Systems Biology Address: Emeritus Scientist, Department of Physics, Bose Institute, ...

Lohia, Prof. Anuradha

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2007 Section: General Biology. Lohia, Prof. Anuradha Ph.D. (Calcutta) Council Service: 2010-12. Date of birth: 11 June 1956. Specialization: Cell Cycle of Protozoan Parasite, Molecular Genetics & Genomics and Regulation of Gene Expression Address: Vice Chancellor ...

Prof. Rengaswamy Ramesh

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2001 Section: Earth & Planetary Sciences. Ramesh, Prof. Rengaswamy Ph.D. (Gujarat), FNA, FNASc, FTWAS Council Service: 2016 - April 2018. Date of birth: 2 June 1956. Date of death: 2 April 2018. Specialization: Palaeoclimatology & Climate Modelling, Mass Spectrometry, ...

Viswanadham, Prof. Nukala

Indian Academy of Sciences (India)

Viswanadham, Prof. Nukala Ph.D. (IISc), FNA, FTWAS, FNAE Council Service: 1992-97; Secretary: 1992-97. Date of birth: 9 November 1943. Specialization: Business Models, Blockchain & Supply Chain Networks Address: INSA Senior Scientist, CSA Department, Indian Institute of Science, Bengaluru 560 012, Karnataka

Bhattacharya, Prof. Alok

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2015 Section: General Biology. Bhattacharya, Prof. Alok Ph.D. (JNU), FNA. Date of birth: 2 February 1951. Specialization: Molecular Parasitology, Computational Genomics, Rare Genetic Disorders Address: School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, ...

Das, Prof. Saumitra

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2009 Section: General Biology. Das, Prof. Saumitra Ph.D. (Calcutta), FNASc, FNA. Date of birth: 20 January 1962. Specialization: Molecular Virology, Molecular Biology and Cell Biology Address: Microbiology and Cell Biology Department, Indian Institute of Science, Bengaluru 560 012, Karnataka

Bhattacharya, Prof. Sudha

Indian Academy of Sciences (India)

Elected: 2001 Section: General Biology. Bhattacharya, Prof. Sudha Ph.D. (IARI, New Delhi), FNASc, FNA Council Service: 2016. Date of birth: 7 March 1952. Specialization: Molecular Biology, Molecular Parasitology and Genomics Address: Professor, School of Environmental Sciences, Jawaharlal Nehru University, New ...

Prof. Xiao Shaoqin's Experience in Acupuncture Treatment

Institute of Scientific and Technical Information of China (English)

许国杰

2001-01-01

@@ Having been engaged in TCM for 50 years, Prof. Xiao Shaoqin has got rich experience in acupuncture. The author has pursued advanced studies for 3 years under his guidance, and has learned a lot from him. The following is a report of Prof. Xiao Shaoqin's experience for treating 3 typical eases.

Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.

Science.gov (United States)

Chacinska, Agnieszka; van der Laan, Martin; Mehnert, Carola S; Guiard, Bernard; Mick, David U; Hutu, Dana P; Truscott, Kaye N; Wiedemann, Nils; Meisinger, Chris; Pfanner, Nikolaus; Rehling, Peter

2010-01-01

Mitochondrial import of cleavable preproteins occurs at translocation contact sites, where the translocase of the outer membrane (TOM) associates with the presequence translocase of the inner membrane (TIM23) in a supercomplex. Different views exist on the mechanism of how TIM23 mediates preprotein sorting to either the matrix or inner membrane. On the one hand, two TIM23 forms were proposed, a matrix transport form containing the presequence translocase-associated motor (PAM; TIM23-PAM) and a sorting form containing Tim21 (TIM23(SORT)). On the other hand, it was reported that TIM23 and PAM are permanently associated in a single-entity translocase. We have accumulated distinct transport intermediates of preproteins to analyze the translocases in their active, preprotein-carrying state. We identified two different forms of active TOM-TIM23 supercomplexes, TOM-TIM23(SORT) and TOM-TIM23-PAM. These two supercomplexes do not represent separate pathways but are in dynamic exchange during preprotein translocation and sorting. Depending on the signals of the preproteins, switches between the different forms of supercomplex and TIM23 are required for the completion of preprotein import.

Ghosh, Prof. Pradyut

Indian Academy of Sciences (India)

Ghosh, Prof. Pradyut Ph.D. (IIT, Kanpur). Date of birth: 17 February 1970. Specialization: Chemical Sensing of Ions, Anion & Ion Pair Recognition Chemistry, Interlocked Molecular Systems & Self-Assembly Address: Department of Inorganic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 ...

Rao, Prof. Sumathi

Indian Academy of Sciences (India)

Rao, Prof. Sumathi Ph.D. (SUNY, Stony Brook), FNASc. Date of birth: 5 December 1956. Specialization: Theoretical Condensed Matter Physics, Quantum field Theory Address: Harish Chandra Research Institute, Chhatnag Road, Jhusi, Allahabad 211 019, U.P.. Contact: Office: (0532) 227 4303. Residence: (0532) 227 4002

Padmanaban, Prof. Govindarajan

Indian Academy of Sciences (India)

Padmanaban, Prof. Govindarajan Ph.D. (IISc), FNA, FNASc, FTWAS Council Service: 1986-88, 1992-97; Vice-President: 1992-97. Date of birth: 20 March 1938. Specialization: Molecular Biology, Recombinant DNA and Malarial Parasite Address: NASI Senior Scientist, Department of Biochemistry, Indian Institute of Science, ...

Cowsik, Prof. Ramanath

Indian Academy of Sciences (India)

Cowsik, Prof. Ramanath Ph.D. (Mumbai), FNA, FNASc, FTWAS. Date of birth: 29 August 1940. Specialization: Astrophysics, Elementary Particles Cosmology, Gravitation Address: Department of Physics, Washington University in St. Louis, Campus Box 1105, One Brookings Drive, St. Louis, MO 63130-4899, U.S.A.. Contact:

Mukhopadhyay, Prof. Dhrubajyoti

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1988 Section: Earth & Planetary Sciences. Mukhopadhyay, Prof. Dhrubajyoti Ph.D. (London), FNA, FNASc. Date of birth: 19 September 1938. Specialization: Structural Geology, Precambrian Geology Address: G-7, MIG Housing Colony, 25/3, Raja Manindra Road, Kolkata 700 037, ...

Ramanathan, Prof. Veerabhadran

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2014 Honorary. Ramanathan, Prof. Veerabhadran. Date of birth: 24 November 1944. Address: Distinguished Victor C Alderson Professor, of Climate Sci., Scripps Institution of, Oceanography, UC at San Diego, 9500 Gilman Drive,MC 0221, La Jolla, CA 92093-0221, USA Contact:

Bose, Prof. Arup

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2006 Section: Mathematical Sciences. Bose, Prof. Arup Ph.D. (ISI, Calcutta), FNA, FNASc. Date of birth: 1 April 1959. Specialization: Probability and Statistics, Economics Address: Professor, Statistics & Mathematics Unit, Indian Statistical Institute, 203, B.T. Road, Kolkata 700 108, ...

Das, Prof. Gobardhan

Indian Academy of Sciences (India)

Das, Prof. Gobardhan Ph.D. (Imtech), FNASc. Date of birth: 10 December 1966. Specialization: Immunology, Infectious Diseases, Cell Biology Address: Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110 067, U.T.. Contact: Office: (011) 2670 4559, 2673 8824. Residence: (0124) 424 2351

Dhar, Prof. D

Indian Academy of Sciences (India)

Home; Fellowship; Associateship. Associate Profile. Period: 1983–1986. Dhar, Prof. D. Date of birth: 30 October 1951. Specialization: Statistical Physics Address during Associateship: Theoretical Physics Group, Tata Inst. of Fundamental Research, Homi Bhabha Road, Mumbai 400 005. YouTube; Twitter; Facebook; Blog ...

Cooperation of TOM and TIM23 complexes during translocation of proteins into mitochondria.

Science.gov (United States)

Waegemann, Karin; Popov-Čeleketić, Dušan; Neupert, Walter; Azem, Abdussalam; Mokranjac, Dejana

2015-03-13

Translocation of the majority of mitochondrial proteins from the cytosol into mitochondria requires the cooperation of TOM and TIM23 complexes in the outer and inner mitochondrial membranes. The molecular mechanisms underlying this cooperation remain largely unknown. Here, we present biochemical and genetic evidence that at least two contacts from the side of the TIM23 complex play an important role in TOM-TIM23 cooperation in vivo. Tim50, likely through its very C-terminal segment, interacts with Tom22. This interaction is stimulated by translocating proteins and is independent of any other TOM-TIM23 contact known so far. Furthermore, the exposure of Tim23 on the mitochondrial surface depends not only on its interaction with Tim50 but also on the dynamics of the TOM complex. Destabilization of the individual contacts reduces the efficiency of import of proteins into mitochondria and destabilization of both contacts simultaneously is not tolerated by yeast cells. We conclude that an intricate and coordinated network of protein-protein interactions involving primarily Tim50 and also Tim23 is required for efficient translocation of proteins across both mitochondrial membranes. Copyright © 2014 Elsevier Ltd. All rights reserved.

TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.

Directory of Open Access Journals (Sweden)

Stephanie Jemielity

2013-03-01

Full Text Available Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4 specifically bind phosphatidylserine (PS. TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and as an entry factor for dengue virus. Here we show that TIM1 promotes infection of retroviruses and virus-like particles (VLPs pseudotyped with a range of viral entry proteins, in particular those from the filovirus, flavivirus, New World arenavirus and alphavirus families. TIM1 also robustly enhanced the infection of replication-competent viruses from the same families, including dengue, Tacaribe, Sindbis and Ross River viruses. All interactions between TIM1 and pseudoviruses or VLPs were PS-mediated, as demonstrated with liposome blocking and TIM1 mutagenesis experiments. In addition, other PS-binding proteins, such as Axl and TIM4, promoted infection similarly to TIM1. Finally, the blocking of PS receptors on macrophages inhibited the entry of Ebola VLPs, suggesting that PS receptors can contribute to infection in physiologically relevant cells. Notably, infection mediated by the entry proteins of Lassa fever virus, influenza A virus and SARS coronavirus was largely unaffected by TIM1 expression. Taken together our data show that TIM1 and related PS-binding proteins promote infection of diverse families of enveloped viruses, and may therefore be useful targets for broad-spectrum antiviral therapies.

Rao, Prof. Kaza Kesava

Indian Academy of Sciences (India)

Elected: 1992 Section: Engineering & Technology. Rao, Prof. ... Address: Professor, Department of Chemical Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: ... Upcoming Refresher Courses. Topology 02 to 14 ...

Chakravorty, Prof. Animesh

Indian Academy of Sciences (India)

Elected: 1975 Section: Chemistry. Chakravorty, Prof. Animesh Ph.D. (Calcutta), FNA, FTWAS Council Service: 1986-91. Date of birth: 30 June 1935. Specialization: Inorganic Chemistry Address: Flat 8/3, 6, Sunny Park, Ballygunge, Kolkata 700 019, W.B.. Contact: Residence: (033) 2485 8327. Mobile: 94338 01715

Nath, Prof. Girishwar

Indian Academy of Sciences (India)

Fellow Profile. Elected: 1981 Section: Mathematical Sciences. Nath, Prof. Girishwar Ph.D. (Budapest). Date of birth: 17 July 1932. Specialization: Fluid Mechanics, Magnetohydrodynamics and Turbomachines Address: c/o Dr S.K. Sinha, Type IV/17, KNIT Campus, Kamala Nehru Institute of, Technology, Sultanpur 228 118, ...

Mahadevan, Prof. Priya

Indian Academy of Sciences (India)

Elected: 2014 Section: Physics. Mahadevan, Prof. Priya Ph.D. (IISc). Date of birth: 19 August 1970. Specialization: Electronic Structure of Materials, Magnetism, Nanostructure Materials Address: Associate Professor, SN Bose National Centre for Basic Sciences, JD Block, Sector 3, Salt Lake, Kolkata 700 098, W.B.. Contact:

Tim Berners-Lee, World Wide Web inventor

CERN Multimedia

1994-01-01

Former physicist, Tim Berners-Lee invented the World Wide Web as an essential tool for high energy physics at CERN from 1989 to 1994. Together with a small team he conceived HTML, http, URLs, and put up the first server and the first 'what you see is what you get' browser and html editor. Tim is now Director of the Web Consortium W3C, the International Web standards body based at INRIA, MIT and Keio University.

Ramachandran, Prof. Raghavan

Indian Academy of Sciences (India)

Ramachandran, Prof. Raghavan Ph.D. (Chicago), FNASc. Date of birth: 15 February 1940. Specialization: Particle Physics Address: Flat 12, Khagol Society, Panchvati, Pashan, Pune 411 008, Maharashtra Contact: Residence: (020) 6607 5892. Mobile: 94220 04597. Email: rr_1940@yahoo.co.in, rr@imsc.res.in. YouTube ...

Sarkar, Prof. Chitra

Indian Academy of Sciences (India)

Sarkar, Prof. Chitra M.B.B.S. (Bangalore), M.D. (AIIMS), FRC Path. (London), FNASc, FAMS, FNA Council Service: 2013-15. Date of birth: 11 September 1955. Specialization: Neuropathology Address: Professor, Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, U.T.. Contact:

Chakraborty, Prof. Ranajit

Indian Academy of Sciences (India)

Elected: 2006 Honorary. Chakraborty, Prof. Ranajit. Date of birth: 1946. Address: Director, Center for Computational Genomics, University of North Texas, HSC, 3500 Camp Bowie Blvd, CBH 249, Fort Worth, TX 76107, U.S.A.. Contact: Office: (+1-817) 735 2421. Fax: (+1-817) 735 5016. Email: ranajit.chakraborty@unthsc.

Chakravarti, Prof. Aravinda

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2008 Honorary. Chakravarti, Prof. Aravinda. Date of birth: 6 February 1954. Address: Director - CCDG, McKusick-Nathans Inst. of Genetic, Medicine, Johns Hopkins Univ., School of Medicine, 733 N.Broadway, Baltimore, MD 21205, USA Contact: Office: (+1-410) 502 7525. Fax: (+1-410) 502 7544

Remarks on Prof. Michał Kokowski’s comment about the studies into the life of Prof. Jan Czochralski (in Polish

Directory of Open Access Journals (Sweden)

Paweł E. TOMASZEWSKI

2015-12-01

Full Text Available Remarks on the critical comments regarding the contents of the paper published after the presentation delivered by the biographer of Prof. Jan Czochralski. Unfortunately, Prof. Kokowski used an incorrect historical approach to such a short paper. The remarks are presented in four main points.

Taming dendritic cells with TIM-3: another immunosuppressive strategy used by tumors.

Science.gov (United States)

Patel, Jaina; Bozeman, Erica N; Selvaraj, Periasamy

2012-12-01

Evaluation of: Chiba S, Baghdadi M, Akiba H et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat. Immunol. 13, 832-842 (2012). The identification of TIM-3 expression on tumor-associated dendritic cells (TADCs) provides insight into another aspect of tumor-mediated immunosuppression. The role of TIM-3 has been well characterized on tumor-infiltrating T cells; however, its role on TADCs was not previously known. The current paper demonstrated that TIM-3 was predominantly expressed by TADCs and its interaction with the nuclear protein HMGB1 suppressed nucleic acid-mediated activation of an effective antitumor immune response. The authors were able to show that TIM-3 interaction with HMGB1 prevented the localization of nucleic acids into endosomal vesicles. Furthermore, chemotherapy was found to be more effective in anti-TIM-3 monoclonal antibody-treated mice or mice depleted of all DCs, which indicated that a significant role is played by TADCs in inhibiting tumor regression. Taken together, these findings identify TIM-3 as a potential target for inducing antitumor immunity in conjunction with DNA vaccines and/or immunogenic chemotherapy in clinical settings.

Ratajczak, Prof. Henryk

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1992 Honorary. Ratajczak, Prof. Henryk. Date of birth: 30 September 1932. Address: Vice President, Faculty of Chemistry, University of Wroclaw, 14, Joliet-Curie Street, 50-383 Wroclaw, Poland Contact: Office: (+48-71) 375 73 18. Residence: (+48-71) 351 98 99. Fax: (+48-71) 328 ...

Heyrovsky, Prof. Jaroslav

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1959 Honorary. Heyrovsky, Prof. Jaroslav Nobel Laureate (Chemistry) - 1959. Date of birth: 20 December 1890. Date of death: 27 March 1967. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Robinson, Prof. Robort

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Robinson, Prof. Robort Nobel Laureate (Chemistry) - 1947. Date of birth: 13 September 1886. Date of death: 8 February 1975. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.

Science.gov (United States)

Meertens, Laurent; Carnec, Xavier; Lecoin, Manuel Perera; Ramdasi, Rasika; Guivel-Benhassine, Florence; Lew, Erin; Lemke, Greg; Schwartz, Olivier; Amara, Ali

2012-10-18

Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases. However, the molecular interactions mediating DV entry are poorly understood. We determined that TIM and TAM proteins, two receptor families that mediate the phosphatidylserine (PtdSer)-dependent phagocytic removal of apoptotic cells, serve as DV entry factors. Cells poorly susceptible to DV are robustly infected after ectopic expression of TIM or TAM receptors. Conversely, DV infection of susceptible cells is inhibited by anti-TIM or anti-TAM antibodies or knockdown of TIM and TAM expression. TIM receptors facilitate DV entry by directly interacting with virion-associated PtdSer. TAM-mediated infection relies on indirect DV recognition, in which the TAM ligand Gas6 acts as a bridging molecule by binding to PtdSer within the virion. This dual mode of virus recognition by TIM and TAM receptors reveals how DVs usurp the apoptotic cell clearance pathway for infectious entry. Copyright © 2012 Elsevier Inc. All rights reserved.

TPÜ muuseumis avati prof Raimo Pullati isikunäitus

Index Scriptorium Estoniae

2002-01-01

17. aprillil avati TPÜ muuseumis prof Raimo Pullati isikunäitus. Näitusel on eksponeeritud ka kaheksa teost, mille eest autasustati prof Pullatit 2001. aastal Balti Assamblee teaduspreemigaga : [täistekst

Tim-3 Up-regulation in Patients with Gastric Cancer and Peptic Ulcer Disease

Science.gov (United States)

Naghavi-Alhosseini, Mahdieh; Tehrani, Mohsen; Ajami, Abolghasem; Rafiei, Alireza; Taghvaei, Tarang; Vahedi-Larijani, Laleh; Hossein-Nataj, Hadi; Asgarian-Omran, Hossein

2017-01-01

Background: T-cell immunoglobulin and mucin domain protein-3 (Tim-3), an inhibitory immunoregulatory receptor, has been recently implicated in tumor biology and tumor-associated immune suppression. In the present study, expression of Tim-3 was evaluated in gastric cancer (GC) and peptic ulcer disease (PUD) at both mRNA and protein levels. Methods: A total of 133 gastric tissue biopsies, comprising 43 from GC cases, 48 from PUD and 42 from non-ulcer dyspepsia (NUD) serving as controls were collected. Additionally, non-neoplastic adjacent tissue biopsies were also obtained from 6 patients with GC. Infection with Helicobacter pylori was determined by the rapid urease test for all participants and H&E staining was conducted for GC and PUD patients. Tim-3 relative mRNA expression was determined by SYBR Green based Real-Time PCR using β-actin as a reference gene. Tim-3 protein expression was also studied by immunohistochemistry in 7 GC, 7 PUD and 10 NUD tissue samples. Results: Tim-3 was expressed at higher levels in GC (p=0.030) and PUD (p=0.022) cases compared to he NUD group. Among paired samples obtained from gastric cancer patients, tumor tissues showed elevated Tim-3 expression (p=0.019) in comparison with adjacent non-neoplastic biopsies. Tim-3 mRNA findings were supported by detection of more Tim-3 protein in cancerous (p=0.002) and ulcerative (p=0.01) tissues than in controls. Tim-3 was similarly expressed in H. pylori positive and negative cases. Conclusion: Higher Tim-3 expression in patients with gastric cancer and peptic ulcer implies that it might be involved in immune regulation and establishment of these gastrointestinal diseases. Targeted immunotherapy by blocking of inhibitory receptors like Tim-3 could be a promising approach for gastric cancer treatment. PMID:28441784

Day 2 closing lecture: Anthropocene's archive?

International Nuclear Information System (INIS)

Van Wyck, Peter

2015-01-01

Prof. Peter van Wyck's lecture drew from Crutzen and Stoermer's concept of the Anthropocene and argued for its theoretical, practical, and rhetorical value with regard to the broad set of concerns that brought participants to Verdun. As an ontological claim, the Anthropocene offers a conceptual challenge to any meaningful distinction between 'human' and 'natural' history: the human and natural are globally merged like never before (referring to issues such as global warming, biodiversity, space debris, etc.). The Anthropocene is a new fundamental concept and a philosophical event. It marks, for instance, the time when we ask for consideration of time scales beyond anthropometric dimensions. Within the geological, social, and human sciences, one of the questions of the Anthropocene circles around when it would have started. There are various competing ideas about this. Some date it back to the acquisition of fire, others to the Industrial Revolution, and others to the great acceleration of science and technology in the mid-20. century. Nuclear energy has also been suggested as a signature. Overall, Prof. van Wyck suggested that the Anthropocene, as a kind of cultural memo, offers a moment in which cultural awareness around questions relating to nuclear energy may be broadened and enhanced

Yadav, Prof. Ganapati Dadasaheb

Indian Academy of Sciences (India)

Elected: 2017 Section: Engineering & Technology. Yadav, Prof. Ganapati Dadasaheb Ph.d. (Bombay). Date of birth: 14 September 1952. Specialization: Green Chemistry & Engineering, Catalysis Science & Engineering Address: Vice Chancellor, Institute of Chemical Technology, Matunga, Mumbai 400 019, Maharashtra

Analysis of TIMS performance subjected to simulated wind blast

Science.gov (United States)

Jaggi, S.; Kuo, S.

1992-01-01

The results of the performance of the Thermal Infrared Multispectral Scanner (TIMS) when it is subjected to various wind conditions in the laboratory are described. Various wind conditions were simulated using a 24 inch fan or combinations of air jet streams blowing toward either or both of the blackbody surfaces. The fan was used to simulate a large volume of air flow at moderate speeds (up to 30 mph). The small diameter air jets were used to probe TIMS system response in reaction to localized wind perturbations. The maximum nozzle speed of the air jet was 60 mph. A range of wind directions and speeds were set up in the laboratory during the test. The majority of the wind tests were conducted under ambient conditions with the room temperature fluctuating no more than 2 C. The temperature of the high speed air jet was determined to be within 1 C of the room temperature. TIMS response was recorded on analog tape. Additional thermistor readouts of the blackbody temperatures and thermocouple readout of the ambient temperature were recorded manually to be compared with the housekeeping data recorded on the tape. Additional tests were conducted under conditions of elevated and cooled room temperatures. The room temperature was varied between 19.5 to 25.5 C in these tests. The calibration parameters needed for quantitative analysis of TIMS data were first plotted on a scanline-by-scanline basis. These parameters are the low and high blackbody temperature readings as recorded by the TIMS and their corresponding digitized count values. Using these values, the system transfer equations were calculated. This equation allows us to compute the flux for any video count by computing the slope and intercept of the straight line that relates the flux to the digital count. The actual video of the target (the lab floor in this case) was then compared with a simulated target. This simulated target was assumed to be a blackbody at emissivity of .95 degrees and the temperature was

Tim Berners-Lee and Kofi Annan during the WSIS

CERN Multimedia

Patrice Loïez

2003-01-01

During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Tim Berners-Lee and Kofi Annan during the WSIS

CERN Multimedia

Patrice Loïez

2003-01-01

During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee, W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Dhavale, Prof. Dilip Dattatray

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2009 Section: Chemistry. Dhavale, Prof. Dilip Dattatray Ph.D. (Pune), FNASc. Date of birth: 18 February 1956. Specialization: Natural Products Chemistry, Carbohydrate Chemistry, Photochemistry, Reaction Mechanism, Medicinal Chemistry Address: Department of Chemistry, ...

Inamdar, Prof. Maneesha Shreedhar

Indian Academy of Sciences (India)

Inamdar, Prof. Maneesha Shreedhar Ph.D. (Bombay). Date of birth: 25 February 1967. Specialization: Stem Cell Biology, Cardiovascular Development, Hematopoiesis & Angiogenesis Address: Molecular Biology & Genetics Unit, JN Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, Karnataka Contact:

Architecture of the TIM23 inner mitochondrial translocon and interactions with the matrix import motor.

Science.gov (United States)

Ting, See-Yeun; Schilke, Brenda A; Hayashi, Masaya; Craig, Elizabeth A

2014-10-10

Translocation of proteins from the cytosol across the mitochondrial inner membrane is driven by action of the matrix-localized multi-subunit import motor, which is associated with the TIM23 translocon. The architecture of the import apparatus is not well understood. Here, we report results of site-specific in vivo photocross-linking along with genetic and coimmunoprecipitation analyses dissecting interactions between import motor subunits and the translocon. The translocon is composed of the two integral membrane proteins Tim23 and Tim17, each containing four membrane-spanning segments. We found that Tim23 having a photoactivatable cross-linker in the matrix exposed loop between transmembrane domains 1 and 2 (loop 1) cross-linked to Tim44. Alterations in this loop destabilized interaction of Tim44 with the translocon. Analogously, Tim17 having a photoactivatable cross-linker in the matrix exposed loop between transmembrane segments 1 and 2 (loop 1) cross-linked to Pam17. Alterations in this loop caused destabilization of the interaction of Pam17 with the translocon. Substitution of individual photoactivatable residues in Tim44 and Pam17 in regions we previously identified as important for translocon association resulted in cross-linking to Tim23 and Tim17, respectively. Our results are consistent with a model in which motor association is achieved via interaction of Tim23 with Tim44, which serves as a scaffold for association of other motor components, and of Tim17 with Pam17. As both Tim44 and Pam17 have been implicated as regulatory subunits of the motor, this positioning is conducive for responding to conformational changes in the translocon upon a translocating polypeptide entering the channel. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Prof. Elizaveta Karamihailova - The first lady of the Bulgarian physics (The contributions of prof. E. Karamihailova in radioactive studies)

International Nuclear Information System (INIS)

Balabanov, N.; Stoeva, M.; Lazarova, P.

2012-01-01

Prof. Elizaveta Karamihailova (1897-1968) is the first Bulgarian nuclear physicist and the first Bulgarian woman with an academic degree. Prof. Karamihajlova spent a significant period of time working at the Radium Institute in Vienna (1923-1935) and at the Cavendish Laboratory in Cambridge (1935-1939). She studies the nuclear reactions and the most up-to-date problems of the nuclear physics during the 1930's - neutron discovery, artificial radioactivity, split of atom nuclei. Following her return in Bulgaria (1939), E. Karamihailova continues the studies of Prof. P. Penchev to measure radioactivity of natural objects such as drinking and mineral water, soil, rocks, mud-curing. She also studies the radioactive pollution of the uranium mining regions, radioactivity due to nuclear tests. She is the founder of the first radiation protection activities in Bulgaria. (authors)

Ojha, Prof. Devendra Kumar

Indian Academy of Sciences (India)

Elected: 2015 Section: Physics. Ojha, Prof. Devendra Kumar Ph.D. (Strasbourg). Date of birth: 23 August 1967. Specialization: Star Formation & Interstellar Medium, Infrared Astronomy, Astronomical Instrumentation Address: Department of Astronomy & Astrophysics, Tata Institute of Fundamental Research, Homi Bhabha ...

Arakeri, Prof. Jaywant Hanumappa

Indian Academy of Sciences (India)

Elected: 2011 Section: Engineering & Technology. Arakeri, Prof. Jaywant Hanumappa Ph.D. (Caltech), FNAE. Date of birth: 15 November 1956. Specialization: Fluid Mechanics, Heat Transfer, Turbulence Address: Department of Mechanical Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

Murty, Prof. Budharaju Srinivasa

Indian Academy of Sciences (India)

Murty, Prof. Budharaju Srinivasa Ph.D. (IISc), FNA, FNAE, FNASc. Date of birth: 13 February 1964. Specialization: High Entropy Alloys, Nanocrystalline Materials, Bulk Metallic Gases, In-situ Composites, Nonequilibrium Processing Address: Department of Metallurgical & Materials Engineering, Indian Institute of Technology, ...

Maji, Prof. Tapas Kumar

Indian Academy of Sciences (India)

Elected: 2018 Section: Chemistry. Maji, Prof. Tapas Kumar Ph.D. (Jadavpur). Date of birth: 1 August 1974. Specialization: Porous Materials, Inorganic-Organic Hybrid nanomaterials, Molecule-based Magnetic& Optoelectronic Materials Address: Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for ...

Chakraborty, Prof. Partha Sarathi

Indian Academy of Sciences (India)

Elected: 2018 Section: Mathematical Sciences. Chakraborty, Prof. Partha Sarathi Ph.D. (ISI), FNASc. Date of birth: 18 November 1973. Specialization: Operator Algebras, Noncommutative Geometry, Quantum Groups Address: The Institute of Mathematical Sciences, CIT Campus, Taramani, Chennai 600 113, T.N.. Contact:

Sane, Prof. Sanjay Prafullachandra

Indian Academy of Sciences (India)

Sane, Prof. Sanjay Prafullachandra Ph.D. (Univ. Calif., Berkeley). Date of birth: 12 September 1970. Specialization: Neuroethology, Biomechanics, Fluid Mechanics Address: National Centre for Biological Sciences, GKVK Campus, Bengaluru 560 065, Karnatka Contact: Office: (080) 2366 7020. Residence: (080) 4097 0586

Ramakrishna, Prof. Balakrishnan Siddartha

Indian Academy of Sciences (India)

Ramakrishna, Prof. Balakrishnan Siddartha MD, DM & Ph.D. (Madras), FAMS, FNA. Date of birth: 26 October 1952. Specialization: Gastroenterology, Nutrition, Inflammatory Bowel Disease, Gastrointestinal Microbiome Stem Cells Address: Flat No. 202-2-03, GVSPL Green Park, 342, Vaidyanathan Street, Nungambakkam, ...

Gadre, Prof. Shridhar Ramchandra

Indian Academy of Sciences (India)

Fellow Profile. Elected: 1991 Section: Chemistry. Gadre, Prof. Shridhar Ramchandra Ph.D. (IIT, Kanpur), FNA. Date of birth: 20 May 1950. Specialization: Quantum Chemistry and Computer Applications Address: Interdisciplinary School of Scientific Computing, University of Pune, Ganeshkhind, Pune 411 007, Maharashtra

Ramakrishnan, Prof. Palayanoor Sivaswamy

Indian Academy of Sciences (India)

Ramakrishnan, Prof. Palayanoor Sivaswamy Ph.D. (Banaras), FNA, FNASc, FTWAS. Date of birth: 24 December 1936. Specialization: Socio-ecology, Environment and Sustainable Development Address: INSA Honorary Scientist, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110 067, U.T.

Chakraborti, Prof. Asit Kumar

Indian Academy of Sciences (India)

Chakraborti, Prof. Asit Kumar Ph.D. (Jadavpur). Date of birth: 15 August 1954. Specialization: Synthetic Organic Chemistry, Green Chemistry, Medicinal Chemistry Address: Head, Department of Medicinal chemistry, National Institute of Pharmaceutical Education & Research, Sector 67, SAS Nagar 160 062, Panjab Contact:

Balaji, Prof. Kithiganahalli Naranayaswamy

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2016 Section: General Biology. Balaji, Prof. Kithiganahalli Naranayaswamy Ph.D. (IISc), FNASc, FNA. Date of birth: 7 March 1966. Specialization: Immunology, Infectious Diseases Address: Department of Microbiology & Cell Biology, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

Prof. Maitra, Uday (Secretary)

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1998 Section: Chemistry. Maitra, Prof. Uday Ph.D. (Columbia), FNA Council Service: 2013-; Secretary: 2013-. Date of birth: 8 November 1957. Specialization: Photoluminescent Sensors, Chemistry of Bile Acids, Organo & Hydrogels, Soft Composite Materials Address: Professor ...

Sarma, Prof. Dipankar Das

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1993 Section: Chemistry. Sarma, Prof. Dipankar Das Ph.D. (IISc), FNA, FNASc, FTWAS Council Service: 2016-. Date of birth: 15 September 1955. Specialization: Strongly Interacting Electron Systems, Disordered Systems, Nanomaterials and Energy Materials Address: Professor ...

Antia, Prof. Hormazad Maneck

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1999 Section: Physics. Antia, Prof. Hormazad Maneck Ph.D. (Mumbai), FNA,. Date of birth: 6 November 1955. Specialization: Solar Physics, Helioseismology and Numerical Techniques Address: Professor, Astrophysics Group, Tata Institute of Fundamental Research, Homi Bhabha ...

Iyengar, Prof. Rangachar Narayana

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1990 Section: Engineering & Technology. Iyengar, Prof. Rangachar Narayana Ph.D. (IISc), FNASc, FNAE. Date of birth: 2 June 1943. Specialization: Structural Dynamics, Earthquake Engineering, Applied Stochastics and History of Science Address: Centre for Advanced Research ...

Gopinathan, Prof. Melethil Sankaran

Indian Academy of Sciences (India)

Elected: 1988 Section: Chemistry. Gopinathan, Prof. Melethil Sankaran Ph.D. (IIT, Kanpur), FNA. Date of birth: 8 October 1942. Specialization: Quantum Chemistry and Nonlinear Dynamics in Chemistry & Biology Address: Professor Emeritus, Indian Institute of Science Education & Research, Vithura, Thiruvananthapuram ...

Pai, Prof. Mangalore Anantha

Indian Academy of Sciences (India)

Elected: 1979 Section: Engineering & Technology. Pai, Prof. Mangalore Anantha Ph.D. (UC, Berkeley), FNA, FNAE, FIEEE. Date of birth: 5 October 1931. Specialization: Smart Grid, Power Systems, Stability, Control and Computation Address: Emeritus Professor, Department of Electrical & Computer Engineering, University ...

Jagirdar, Prof. Balaji Rao

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2013 Section: Chemistry. Jagirdar, Prof. Balaji Rao Ph.D. (Kansas State). Date of birth: 9 September 1965. Specialization: Organometallic Chemistry, Materials Chemistry, Catalysis Address: Department of Inorganic & Physical Chemistry, Indian Institute of Science, Bengaluru 560 012, Karnataka

Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy

DEFF Research Database (Denmark)

Meggyes, Matyas; Miko, Eva; Polgar, Beata

2014-01-01

PROBLEM: The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/TIM-3 pathway as an important...... negative regulator of Th1 immunity and tolerance induction. Data about the TIM-3/Gal-9 pathway in the pathogenesis of human diseases is emerging, but their possible role during human pregnancy is not precisely known. The aim of our study was to investigate the number, phenotype and functional activity...... of TIM-3+ peripheral blood mononuclear cells during healthy human pregnancy. METHODS OF STUDY: 57 healthy pregnant women [first trimester (n = 16); second trimester (n = 19); third trimester (n = 22)] and 30 non-pregnant controls were enrolled in the study. We measured the surface expression of TIM-3...

Bapat, Prof. Ravindra Bhalchandra

Indian Academy of Sciences (India)

Elected: 2000 Section: Mathematical Sciences. Bapat, Prof. Ravindra Bhalchandra Ph.D. (Illinois), FNA. Date of birth: 20 December 1954. Specialization: Combinatorial Linear Algebra and Generalised Inverses Address: Statistics & Mathematics Unit, Indian Statistical Institute, 7, SJS Sansanwal Marg, New Delhi 110 016, ...

Chakrabarti, Prof. Partha Pratim

Indian Academy of Sciences (India)

Elected: 2000 Section: Engineering & Technology. Chakrabarti, Prof. Partha Pratim Ph.D. (IIT, Kharagpur), FNA, FNAE. Date of birth: 1 October 1962. Specialization: Artificial Intelligence, Computer Aided Design for VLSI and Algorithms Address: Director, Indian Institute of Technology, Kharagpur 721 302, W.B.. Contact:

VijayRaghavan, Prof. Krishnaswamy

Indian Academy of Sciences (India)

VijayRaghavan, Prof. Krishnaswamy Ph.D. (Mumbai), FNA, FNASc, FRS, FTWAS, Foreign Assoc. (US Natl. Acad. Sci.) Council Service: 2007-2009. Date of birth: 3 February 1954. Specialization: Developmental Biology, Genetics and Neurogenetics Address: Secretary, Department of Biotechnology, Block 2, CGO Complex, ...

Patel, Prof. Bhisma Kumar

Indian Academy of Sciences (India)

Elected: 2018 Section: Chemistry. Patel, Prof. Bhisma Kumar Ph.D. (IIT, Kanpur), FNASc. Date of birth: 6 August 1965. Specialization: Organic Synthesis, Reaction Mechanisms, Green Chemistry Address: Department of Chemistry, Indian Institute of Technology, Guwahati 781 039, Assam Contact: Office: (0361) 258 2307

Shashidhara, Prof. Lingadahalli Subrahmanya

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2007 Section: Animal Sciences. Shashidhara, Prof. Lingadahalli Subrahmanya Ph.D. (Cambridge), FNA, FNASc. Date of birth: 23 March 1963. Specialization: Developmental Biology, Evolution and Genetics Address: Indian Institute of Science Education and Research (IISER), Dr Homi Bhabha Road, ...

Pandit, Prof. Aniruddha Bhalachandra

Indian Academy of Sciences (India)

Pandit, Prof. Aniruddha Bhalachandra Ph.D. (Mumbai), FNAE, FNA, FNASc, FTWAS. Date of birth: 7 December 1957. Specialization: Design of Multiphase Reactors, Cavitation Phenomena and Environmental & Energy Engineering Address: Dean (HR), Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai 400 ...

Yadav, Prof. Veejendra Kumar

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2007 Section: Chemistry. Yadav, Prof. Veejendra Kumar Ph.D. (Baroda). Date of birth: 13 June 1956. Specialization: Synthetic Organic Chemistry and Physical Organic Chemistry Address: Professor, Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, U.P.

Gopinathan, Prof. Karumathil Puthanveetil

Indian Academy of Sciences (India)

Elected: 1987 Section: General Biology. Gopinathan, Prof. Karumathil Puthanveetil Ph.D. (IISc), FNA, FNASc. Date of birth: 13 June 1939. Specialization: Molecular Biology, Recombinant DNA & Genetic Engineering, Molecular Virology, Biotechnology and Developmental Biology Address: Abhiman, 369, 11th Cross, II Block, ...

Lakhotia, Prof. Subhash Chandra

Indian Academy of Sciences (India)

Elected: 1994 Section: Animal Sciences. Lakhotia, Prof. Subhash Chandra Ph.D. (Calcutta), FNA, FNASc. Date of birth: 4 October 1945. Specialization: Ayurvedic Biology, Cytogenetics, Gene Expression, Stress Biology and Molecular Biology Address: INSA Senior Scientist, Department of Zoology, Banaras Hindu University ...

Rao, Prof. Maddali Nageswara

Indian Academy of Sciences (India)

Rao, Prof. Maddali Nageswara Dr. rer. nat. (Cologne). Date of birth: 11 July 1931. Specialization: Solar System Physics, Mars Fundamental Research, Earth & Planetary Sciences and Lunar & Meteorite Sample Studies Address: 16931, Tower Ridge, Friendswood, Texas 77546, USA Contact: Residence: (+1-281) 993 9191

Rao, Prof. Valipe Ramgopal

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2009 Section: Engineering & Technology. Rao, Prof. Valipe Ramgopal FNAE, FNASc, FNA, FIEEE. Date of birth: 16 August 1965. Specialization: Nanoelectronics and Nanotechnology Address: Director, Indian Institute of Technology, Hauz Khas, New Delhi 110 016, U.T.. Contact:

Kapur, Prof. Prakash Chand

Indian Academy of Sciences (India)

Elected: 1988 Section: Engineering & Technology. Kapur, Prof. Prakash Chand Ph.D. (UC, Berkeley), FNAE. Date of birth: 3 July 1935. Specialization: Mineral Processing, Particulate Science & Technology, Mathematical Modelling and Waste Management Address: R-485, New Rajinder Nagar, New Delhi 110 060, U.T.

Kaliappan, Prof. Krishna Pillai

Indian Academy of Sciences (India)

Elected: 2016 Section: Chemistry. Kaliappan, Prof. Krishna Pillai Ph.D. (IISc). Date of birth: 16 March 1968. Specialization: Organic Synthesis, Medicinal Chemistry, Natural Products Address: Department of Chemistry, Indian Institute of Technology, Powai, Mumbai 400 076, Maharashtra Contact: Office: (022) 2576 7177

Chandola-Saklani, Prof. Asha

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1992 Section: Animal Sciences. Chandola-Saklani, Prof. Asha Ph.D. (Banaras). Date of birth: 3 February 1947. Specialization: Ornithology, Conservation Biology and Endocrinology Address: Apeejay Svran Institute of Biosciences and Clinical Research, Plot 26, Sector 32, Gurgaon ...

Khakhar, Prof. Devang Vipin

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1996 Section: Engineering & Technology. Khakhar, Prof. Devang Vipin Ph.D. (Massachusetts), FNA, FNAE, FNASc. Council Service: 2010-12. Date of birth: 7 April 1959. Specialization: Granular Flow & Mixing, Polymer Processing Address: Director, Indian Institute of Technology, ...

Chattaraj, Prof. Pratim Kumar

Indian Academy of Sciences (India)

Elected: 2001 Section: Chemistry. Chattaraj, Prof. Pratim Kumar Ph.D. (IIT, Mumbai), FNA, FNASc, FTWAS. Date of birth: 26 April 1958. Specialization: Hydrogen Storage, Density Functional Theory, Nonlinear Dynamics and Chemical Reactivity, Aromaticity in Metal Clusters Address: Department of Chemistry, Indian Institute ...

Shaila, Prof. Melkote Subbarao

Indian Academy of Sciences (India)

Fellow Profile. Elected: 1993 Section: General Biology. Shaila, Prof. Melkote Subbarao Ph.D. (IISc). Date of birth: 10 October 1945. Specialization: Molecular Virology and Viral Immunology Address: Professor Emeritus, Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560 012, Karnataka

Narasimhan, Prof. Mudumbai Seshachalu

Indian Academy of Sciences (India)

Narasimhan, Prof. Mudumbai Seshachalu Ph.D. (Mumbai), FNA, FNASc, FRS Council Service: 1977-82; Vice-President: 1980-82. Date of birth: 7 June 1932. Specialization: Algebraic & Differential Geometry and Analysis Address: 9, Guruparadise Apartments, 24, 4th Main Road, Amarjyoti Layout, Sanjay Nagar, Bengaluru ...

Bhosle, Prof. Ushadevi Narendra

Indian Academy of Sciences (India)

Bhosle, Prof. Ushadevi Narendra Ph.D. (Bombay), FNASc, FNA. Date of birth: 30 March 1949. Specialization: Algebraic Geometry Address: Flat No. 256, Jal Vayu Towers, NGEF Layout, Bennigannahalli, Bengaluru 560 038, Karnataka Contact: Residence: 99306 41136. Mobile: 88616 96296. Email: usnabh07@gmail.com.

Pandian, Prof. Thavamani Jegajothivel

Indian Academy of Sciences (India)

Elected: 1985 Section: Animal Sciences. Pandian, Prof. Thavamani Jegajothivel Ph.D. (Madras), Dr. rer. nat. (Kiel, Germany), FNA, FNASc, FNAAS, FTWAS, D.Sc. (CIFE, Mumbai). Date of birth: 15 June 1939. Specialization: Genetics and Energetics: Aquaculture Address: 9, Old Natham Road, Opp. Balamandiram, Madurai ...

Parulkar, Prof. Gurukumar Bhalchandra

Indian Academy of Sciences (India)

Parulkar, Prof. Gurukumar Bhalchandra M.S. (Mumbai), FAMS. Date of birth: 1 December 1931. Specialization: Open Heart Surgery, Extracorporeal Circulation, Coronary Bypass Surgery and Vascular Surgery Address: Flat No. 31, Building 4, Haji Ali Government Colony, K K Marg, Mumbai 400 034, Maharashtra Contact:

Mohan Kumar, Prof. Neithalath

Indian Academy of Sciences (India)

Elected: 1993 Section: Mathematical Sciences. Mohan Kumar, Prof. Neithalath Ph.D. (Mumbai). Date of birth: 12 May 1951. Specialization: Commutative Algebra and Algebraic Geometry Address: Department of Mathematics, Washington University at St. Louis, One Brookings Drive, Campus Box 1146, St. Louis, MO 63130, ...

Paulraj, Prof. Arogyaswami J

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2014 Honorary. Paulraj, Prof. Arogyaswami J. Date of birth: 1944. Address: Information Systems Laboratory, Stanford University, 232, David Packard EE Building, 350, Serra Mall, Stanford, CA 94305-9510, USA Contact: Email: apaulraj@stanford.edu. YouTube; Twitter; Facebook ...

Dhar, Prof. Suman Kumar

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2016 Section: General Biology. Dhar, Prof. Suman Kumar Ph.D. (JNU). Date of birth: 6 March 1968. Specialization: DNA Replication, Cell Cycle Control, Molecular Parasitology, Bacteriology Address: Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110 067, U.T.

Chandrashekaran, Prof. Maroli Krishnayya

Indian Academy of Sciences (India)

Elected: 1983 Section: Animal Sciences. Chandrashekaran, Prof. Maroli Krishnayya Ph.D. (Madras), D.Sc. (Madurai), FNA, FNASc, FTWAS Council Service: 1992-97. Date of birth: 4 January 1937. Date of death: 2 July 2009. Specialization: Chronobiology and Animal Behaviour Last known address: Evolutionary and ...

Abhyankar, Prof. Shreeram Shankar

Indian Academy of Sciences (India)

Abhyankar, Prof. Shreeram Shankar Ph.D. (Harvard), FNA. Date of birth: 22 July 1930. Date of death: 2 November 2012. Specialization: Algebra and Algebraic Geometry Last known address: Department of Mathematics, Purdue University, West Lafayette, Indiana 47907, USA. YouTube; Twitter; Facebook; Blog ...

Tyagi, Prof. Anil Kumar

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1995 Section: General Biology. Tyagi, Prof. Anil Kumar Ph.D. (Delhi), FNASc, FNA. Date of birth: 2 April 1951. Specialization: Molecular Biology, Biochemistry and Microbiology Address: Vice Chancellor, Guru Gobind Singh Indraprastha University, Sector 16C, Dwaraka, New Delhi ...

Prof. Parag P. Sadhale

Indian Academy of Sciences (India)

user

2009-07-01

Jul 1, 2009 ... Manimala Sen. Swati Deshpande. Pallavi Kakde. Ritu Gupta. Bhavna P. Bhavin Shah. Harigopala B. Kannan. Anandkumar. Prof. Parag P. Sadhale. Dept. of Microbiology and Cell Biology. July 2009. Financial support. DBT,. Piramal Life Sciences Mumbai. Indian Institute of Science. Bangalore- 560012.

Chaturvedi, Prof. Umesh Chandra

Indian Academy of Sciences (India)

Chaturvedi, Prof. Umesh Chandra M.D. (Lucknow), FRC Path. (London), FAMS, FNA, FNASc, FAAM(USA). Date of birth: 2 March 1939. Specialization: Medical Microbiology, Virology and Immunology Address: 201, Annapurna Apartments, No. 1, Bishop Rocky Street, Faizabad Road, Lucknow 226 007, U.P.. Contact:

A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9

International Nuclear Information System (INIS)

Weyer, Philipp S. van de; Muehlfeit, Michael; Klose, Christoph; Bonventre, Joseph V.; Walz, Gerd; Kuehn, E. Wolfgang

2006-01-01

Tim-3 is a member of the TIM family of proteins (T-cell immunoglobulin mucin) involved in the regulation of CD4+ T-cells. Tim-3 is a T H 1-specific type 1 membrane protein and regulates T H 1 proliferation and the development of tolerance. Binding of galectin-9 to the extracellular domain of Tim-3 results in apoptosis of T H 1 cells, but the intracellular pathways involved in the regulatory function of Tim-3 are unknown. Unlike Tim-1, which is expressed in renal epithelia and cancer, Tim-3 has not been described in cells other than neuronal or T-cells. Using RT-PCR we demonstrate that Tim-3 is expressed in malignant and non-malignant epithelial tissues. We have cloned Tim-3 from an immortalized liver cell carcinoma line and identified a highly conserved tyrosine in the intracellular tail of Tim-3 (Y265). We demonstrate that Y265 is specifically phosphorylated in vivo by the interleukin inducible T cell kinase (ITK), a kinase which is located in close proximity of the TIM genes on the allergy susceptibility locus 5q33.3. Stimulation of Tim-3 by its ligand galectin-9 results in increased phosphorylation of Y265, suggesting that this tyrosine residue plays an important role in downstream signalling events regulating T-cell fate. Given the role of TIM proteins in autoimmunity and cancer, the conserved SH2 binding domain surrounding Y265 could represent a possible target site for pharmacological intervention

The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism.

Science.gov (United States)

Goldman, Aaron David; Beatty, Joshua T; Landweber, Laura F

2016-01-01

The triosephosphate isomerase (TIM) barrel protein fold is a structurally repetitive architecture that is present in approximately 10% of all enzymes. It is generally assumed that this ubiquity in modern proteomes reflects an essential historical role in early protein-mediated metabolism. Here, we provide quantitative and comparative analyses to support several hypotheses about the early importance of the TIM barrel architecture. An information theoretical analysis of protein structures supports the hypothesis that the TIM barrel architecture could arise more easily by duplication and recombination compared to other mixed α/β structures. We show that TIM barrel enzymes corresponding to the most taxonomically broad superfamilies also have the broadest range of functions, often aided by metal and nucleotide-derived cofactors that are thought to reflect an earlier stage of metabolic evolution. By comparison to other putatively ancient protein architectures, we find that the functional diversity of TIM barrel proteins cannot be explained simply by their antiquity. Instead, the breadth of TIM barrel functions can be explained, in part, by the incorporation of a broad range of cofactors, a trend that does not appear to be shared by proteins in general. These results support the hypothesis that the simple and functionally general TIM barrel architecture may have arisen early in the evolution of protein biosynthesis and provided an ideal scaffold to facilitate the metabolic transition from ribozymes, peptides, and geochemical catalysts to modern protein enzymes.

The sociology of big science | Public Lecture by Ulrike Felt | 15 July

CERN Multimedia

2014-01-01

"The sociology of big science" Public Lecture by Prof. Ulrike Felt Tuesday 15 July 2014 - 7.30 p.m. Globe of Science and Innovation Lecture in English, translated in French. Entrance free. Limited number of seats. Reservation essential: +41 22 767 76 76 or cern.reception@cern.ch What science for what kind of society? Reflecting the development of big science Without any doubt, CERN can be described as being among the most ambitious scientific enterprises ever undertaken. For 60 years, the Member States have not only invested considerable financial means into this institution, but have also supported the creation of a highly visionary research programme. And this has led to a change in the way science is done, as captured by the idea of "big science". Yet this naturally also raises a number of quite fundamental questions: How did the meaning of "doing science" change? What justifies societal engagement with and support for such a cost-intensive long-t...

Khorana, Prof. Har Gobind

Indian Academy of Sciences (India)

Elected: 1976 Honorary. Khorana, Prof. Har Gobind Nobel Laureate (Medicine) - 1968. Date of birth: 9 January 1922. Date of death: 9 November 2011. Last known address: Alfred P. Sloan Professor of, Biology and Chemistry, Massachusetts Institute of, Technology, 77 Massachusetts Ave., Cambridge, MA 02139, U.S.A..

Jha, Prof. Sudhanshu Shekhar

Indian Academy of Sciences (India)

Jha, Prof. Sudhanshu Shekhar Ph.D. (Stanford), FNA, FNASc, FTWAS Council Service: 1989-94, Vice-President: 1989-91. Date of birth: 25 December 1940. Specialization: Solid State Theory, Quantum Computing and Photonics Address: 402, Vigyanshila, Juhu-Varsova Link Road, 7 Bungalows, Andheri (W), Mumbai 400 ...

Bhattacherjee, Prof. Satyendra Kumar

Indian Academy of Sciences (India)

Bhattacherjee, Prof. Satyendra Kumar Ph.D. (Notre Dame). Date of birth: 2 October 1926. Date of death: 28 April 2013. Specialization: Experimental Nuclear Physics Last known address: 302B, Tribute, Rajkamal Studio Compound, Off Dr SS Rao Road, Behind Mahatma Gandhi Memorial Hospital, Parel, Mumbai 400 012.

Johri, Prof. Man Mohan

Indian Academy of Sciences (India)

Elected: 1983 Section: General Biology. Johri, Prof. Man Mohan Ph.D. (Delhi), FNA. Date of birth: 15 September 1940. Specialization: Plant Biochemistry, Molecular Biology of Plants and Genetic Engineering Address: Flat No. 32, New Cosmos CHSL, Juhu-Versova Link Road, Andheri (W), Mumbai 400 053, Maharashtra

Kumar, Prof. Har Darshan

Indian Academy of Sciences (India)

Fellow Profile. Elected: 1975 Section: Plant Sciences. Kumar, Prof. Har Darshan Ph.D. (London), FNA, FNASc. Date of birth: 25 February 1934. Specialization: Algology, Microbial Biotechnology, Genetics, Ecology and Environment Address: Mrigtrishna, B.32/32, H.K. 214, Saketnagar Colony, Naria, Varanasi 221 005, U.P.

Kamal, Prof. Aditya Kumar

Indian Academy of Sciences (India)

Elected: 1974 Section: Engineering & Technology. Kamal, Prof. Aditya Kumar Dr. lng. (Paris). Date of birth: 5 July 1927. Specialization: Air Traffic Control, Surveillance, Automation, UAV, GPS, Cyber Security Address: 18, Crystal Circle, Burlington, MA 01803, USA Contact: Office: (+1-781) 890 3330/235. Residence: (+1-781) ...

Nocera, Prof. Daniel G

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2013 Honorary. Nocera, Prof. Daniel G. Date of birth: 1957. Address: Dept. of Chemistry & Chem. Biol., Harvard University, 12, Oxford Street, Cambridge, MA 02138, USA Contact: Office: (+1-617) 495 8904. Email: dnocera@fas.harvard.edu. http://chemistry.harvard.edu/people/daniel-g-nocera.

Bhattacharyya, Prof. Prabhat Kumar

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1976 Section: Chemistry. Bhattacharyya, Prof. Prabhat Kumar Ph.D. (Illinois), FNA. Date of birth: 22 October 1921. Date of death: 16 April 1996. Specialization: Bio-organic Chemistry and Chemical Microbiology Last known address: 177, Jodhpur Park, Flat - 1S, Calcutta 700 068.

Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria.

Science.gov (United States)

Mokranjac, Dejana; Sichting, Martin; Popov-Celeketić, Dusan; Mapa, Koyeli; Gevorkyan-Airapetov, Lada; Zohary, Keren; Hell, Kai; Azem, Abdussalam; Neupert, Walter

2009-03-01

Transport of essentially all matrix and a number of inner membrane proteins is governed, entirely or in part, by N-terminal presequences and requires a coordinated action of the translocases of outer and inner mitochondrial membranes (TOM and TIM23 complexes). Here, we have analyzed Tim50, a subunit of the TIM23 complex that is implicated in transfer of precursors from TOM to TIM23. Tim50 is recruited to the TIM23 complex via Tim23 in an interaction that is essentially independent of the rest of the translocase. We find Tim50 in close proximity to the intermembrane space side of the TOM complex where it recognizes both types of TIM23 substrates, those that are to be transported into the matrix and those destined to the inner membrane, suggesting that Tim50 recognizes presequences. This function of Tim50 depends on its association with TIM23. We conclude that the efficient transfer of precursors between TOM and TIM23 complexes requires the concerted action of Tim50 with Tim23.

Menon, Prof. Thuppalay Kochugovinda

Indian Academy of Sciences (India)

Fellow Profile. Elected: 1974 Section: Physics. Menon, Prof. Thuppalay Kochugovinda Ph.D. (Harvard). Date of birth: 19 December 1928. Specialization: Astrophysics Address: 106-2803, 41st Avenue, Vancouver, British Columbia V6N 4B4, Canada Contact: Office: (+1-604) 822 0330. Residence: (+1-604) 266 1789

Rao, Prof. Kalya Jagannatha

Indian Academy of Sciences (India)

Rao, Prof. Kalya Jagannatha Ph.D. (IIT, Kanpur), D.Sc. (IISc), FNA, FNASc, D.Sc. (h.c., Univ. Bordeaux, France) Council Service: 1998-2003. Date of birth: 7 December 1940. Specialization: Physical Chemistry of Amorphous Solids & Ceramics and Phase Transitions Address: 187/1, Tadvanam Estate, Halasinganahalli Road ...

Cheetham, Prof. Antony Kevin

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2001 Honorary. Cheetham, Prof. Antony Kevin FRS. Date of birth: 16 November 1946. Address: Dept. of Materials Science &, Metallurgy, University of Cambridge, 27, Charles Babbage Road, Cambridge CB3 0FS, uk. Contact: Office: (+44-1223) 74 6733. Fax: (+44-1223) 33 4567

Mukherjee, Prof. Rabindra Nath

Indian Academy of Sciences (India)

Mukherjee, Prof. Rabindra Nath Ph.D. (Calcutta), FNA. Date of birth: 19 April 1953. Specialization: Bioinorganic Chemistry Address: Dept. of Chemistry, Indian Institute of Technology, Kanpur 208 016, U.P.. Contact: Mobile: 98308 39343. Email: rnm@iitk.ac.in, rnath.mukherjee@gmail.com. http://home.iitk.ac.in/~rnm.

Hartl, Prof. Daniel L

Indian Academy of Sciences (India)

Hartl, Prof. Daniel L. Date of birth: 1 January 1943. Address: Higgins Professor of Biology, Dept. of Organismic & Evolutionary, Biology, The Biological Lab., Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA Contact: Office: (+1-617) 496 3917. Email: dhartl@oeb.harvard.edu. YouTube; Twitter; Facebook; Blog ...

Mondal, Prof. Naba Kumar

Indian Academy of Sciences (India)

Mondal, Prof. Naba Kumar Ph.D. (Bombay) D.Sc. (h.c.), FNA, FNASc, FTWAS. Date of birth: 11 March 1951. Specialization: Experimental Particle Physics, Accelerator-based Particle Physics and Neutrino Physics Address: Raja Ramanna Fellow, Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 064, W.B.

Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm.

Science.gov (United States)

Younan, Patrick; Iampietro, Mathieu; Nishida, Andrew; Ramanathan, Palaniappan; Santos, Rodrigo I; Dutta, Mukta; Lubaki, Ndongala Michel; Koup, Richard A; Katze, Michael G; Bukreyev, Alexander

2017-09-26

Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a "cytokine storm." Previous reports have suggested that nonspecific activation of T lymphocytes may play a central role in this phenomenon. T-cell immunoglobulin and mucin domain-containing protein 1 (Tim-1) has recently been shown to interact with virion-associated phosphatidylserine to promote infection. Here, we demonstrate the central role of Tim-1 in EBOV pathogenesis, as Tim-1 -/- mice exhibited increased survival rates and reduced disease severity; surprisingly, only a limited decrease in viremia was detected. Tim-1 -/- mice exhibited a modified inflammatory response as evidenced by changes in serum cytokines and activation of T helper subsets. A series of in vitro assays based on the Tim-1 expression profile on T cells demonstrated that despite the apparent absence of detectable viral replication in T lymphocytes, EBOV directly binds to isolated T lymphocytes in a phosphatidylserine-Tim-1-dependent manner. Exposure to EBOV resulted in the rapid development of a CD4 Hi CD3 Low population, non-antigen-specific activation, and cytokine production. Transcriptome and Western blot analysis of EBOV-stimulated CD4 + T cells confirmed the induction of the Tim-1 signaling pathway. Furthermore, comparative analysis of transcriptome data and cytokine/chemokine analysis of supernatants highlight the similarities associated with EBOV-stimulated T cells and the onset of a cytokine storm. Flow cytometry revealed virtually exclusive binding and activation of central memory CD4 + T cells. These findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of EVD. IMPORTANCE Ebola virus infection is characterized by a massive release of inflammatory mediators, which has come to be known as a cytokine storm. The severity of the cytokine storm is

Guha-Mukherjee, Prof. Sipra

Indian Academy of Sciences (India)

Fellow Profile. Elected: 1988 Section: Plant Sciences. Guha-Mukherjee, Prof. Sipra Ph.D. (Delhi), FNASc. Date of birth: 30 July 1938. Date of death: 15 September 2007. Specialization: Plant Molecular Biology, Plant Tissue Culture and Genetic Engineering Last known address: Garden Estate, M A 1/6-3C, Gurgaon 122 002.

Nicolaou, Prof. Kyriacos Costa

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2007 Honorary. Nicolaou, Prof. Kyriacos Costa. Date of birth: 1946. Address: Department of Chemistry & BRC, Rice University, 6100, Main Street, MS 602, Houston, TX 77005, U.S.A.. Contact: Residence: (+1-713) 348 8860. Fax: (+1-713) 348 8865. Email: kcn@rice.edu. YouTube; Twitter; Facebook ...

Tandon, Prof. Prakash Narain

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1983 Section: Medicine. Tandon, Prof. Prakash Narain M.B.B.S. (Lucknow), M.S., D.Sc. (h.c.), FRCS, FNA, FNASc, FTWAS, FAMS. Date of birth: 13 August 1928. Specialization: Neurosciences and Neurosurgery Address: No. 1, Jagriti Enclave, Vikas Marg Extension, Delhi 110 092, ...

Dodson, Prof. George Guy

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 2003 Honorary. Dodson, Prof. George Guy FRS. Date of birth: 13 January 1937. Date of death: 24 December 2012. Last known address: Division of Protein Structure, National Institute for Medical, Research, Mill Hill, London NW7 1AA, U.K.. YouTube; Twitter; Facebook; Blog ...

Morgan, Prof. Thomas Hunt

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1939 Honorary. Morgan, Prof. Thomas Hunt Nobel Laureate (Medicine) - 1933. Date of birth: 25 September 1866. Date of death: 4 December 1945. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

Ruzicka, Prof. Leopold Stephen

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1957 Honorary. Ruzicka, Prof. Leopold Stephen Nobel Laureate (Chemistry) - 1939. Date of birth: 13 September 1887. Date of death: 26 September 1976. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

Varadhan, Prof. Srinivasa S R

Indian Academy of Sciences (India)

Varadhan, Prof. Srinivasa S R . Date of birth: 2 January 1940. Address: Department of Mathematics, Courant Institute, New York University, 251, Mercer Street, New York, NY 10012, U.S.A.. Contact: Office: (+1-212) 982 9883

TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action

Directory of Open Access Journals (Sweden)

Wenwen Du

2017-03-01

Full Text Available Cancer immunotherapy has produced impressive clinical results in recent years. Despite the success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4 and programmed death receptor 1 (PD-1, a large portion of cancer patients have not yet benefited from this novel therapy. T cell immunoglobulin and mucin domain 3 (TIM-3 has been shown to mediate immune tolerance in mouse models of infectious diseases, alloimmunity, autoimmunity, and tumor Immunity. Thus, targeting TIM-3 emerges as a promising approach for further improvement of current immunotherapy. Despite a large amount of experimental data showing an immune suppressive function of TIM-3 in vivo, the exact mechanisms are not well understood. To enable effective targeting of TIM-3 for tumor immunotherapy, further in-depth mechanistic studies are warranted. These studies will also provide much-needed insight for the rational design of novel combination therapy with other checkpoint blockers. In this review, we summarize key evidence supporting an immune regulatory role of TIM-3 and discuss possible mechanisms of action.

Pauling, Prof. Linus Carl

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1949 Honorary. Pauling, Prof. Linus Carl Nobel Laureate (Chemistry) - 1954; Peace - 1962. Date of birth: 28 February 1901. Date of death: 19 August 1994. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

Pavlov, Prof. Ivan Petrovich

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Pavlov, Prof. Ivan Petrovich Nobel Laureate (Medicine) - 1904. Date of birth: 27 September 1849. Date of death: 27 February 1936. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Haworth, Prof. Walter Norman

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1948 Honorary. Haworth, Prof. Walter Norman Nobel Laureate (Chemistry) - 1937. Date of birth: 19 March 1883. Date of death: 19 March 1950. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Lawrence, Prof. Ernest Orlando

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1954 Honorary. Lawrence, Prof. Ernest Orlando Nobel Laureate (Physics) - 1939. Date of birth: 8 August 1901. Date of death: 27 August 1958. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Hess, Prof. Walter Rudolf

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1966 Honorary. Hess, Prof. Walter Rudolf Nobel Laureate (Medicine) - 1949. Date of birth: 17 March 1881. Date of death: 12 August 1973. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting ...

Hill, Prof. Archibald Vivian

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Hill, Prof. Archibald Vivian Nobel Laureate (Medicine) - 1922. Date of birth: 26 September 1886. Date of death: 3 June 1977. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Granit, Prof. Ragnar Arthur

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1964 Honorary. Granit, Prof. Ragnar Arthur Nobel Laureate (Medicine) - 1967. Date of birth: 30 October 1900. Date of death: 11 March 1991. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Anderson, Prof. Basil Williams

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1964 Honorary. Anderson, Prof. Basil Williams. Date of birth: 3 July 1901. Date of death: 24 February 1984. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

Bose, Prof. Satyendra Nath

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1973 Honorary. Bose, Prof. Satyendra Nath. Date of birth: 1 January 1894. Date of death: 4 February 1974. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

Lewis, Prof. Gilbert Newton

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Lewis, Prof. Gilbert Newton. Date of birth: 25 October 1875. Date of death: 24 March 1946. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

Series, Prof. George William

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1984 Honorary. Series, Prof. George William. Date of birth: 22 February 1920. Date of death: 2 January 1995. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm

Directory of Open Access Journals (Sweden)

Patrick Younan

2017-09-01

Full Text Available Ebola virus (EBOV disease (EVD results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activation of T lymphocytes may play a central role in this phenomenon. T-cell immunoglobulin and mucin domain-containing protein 1 (Tim-1 has recently been shown to interact with virion-associated phosphatidylserine to promote infection. Here, we demonstrate the central role of Tim-1 in EBOV pathogenesis, as Tim-1−/− mice exhibited increased survival rates and reduced disease severity; surprisingly, only a limited decrease in viremia was detected. Tim-1−/− mice exhibited a modified inflammatory response as evidenced by changes in serum cytokines and activation of T helper subsets. A series of in vitro assays based on the Tim-1 expression profile on T cells demonstrated that despite the apparent absence of detectable viral replication in T lymphocytes, EBOV directly binds to isolated T lymphocytes in a phosphatidylserine–Tim-1-dependent manner. Exposure to EBOV resulted in the rapid development of a CD4Hi CD3Low population, non-antigen-specific activation, and cytokine production. Transcriptome and Western blot analysis of EBOV-stimulated CD4+ T cells confirmed the induction of the Tim-1 signaling pathway. Furthermore, comparative analysis of transcriptome data and cytokine/chemokine analysis of supernatants highlight the similarities associated with EBOV-stimulated T cells and the onset of a cytokine storm. Flow cytometry revealed virtually exclusive binding and activation of central memory CD4+ T cells. These findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of EVD.

Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.

Science.gov (United States)

Jang, A Reum; Moravcevic, Katarina; Saez, Lino; Young, Michael W; Sehgal, Amita

2015-02-01

Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA repression in the molecular feedback loop. In Drosophila, nuclear entry of the clock proteins, PERIOD (PER) and TIMELESS (TIM), is tightly controlled, and impairments of this process produce profound behavioral phenotypes. We report here that nuclear entry of PER-TIM in clock cells, and consequently behavioral rhythms, require a specific member of a classic nuclear import pathway, Importin α1 (IMPα1). In addition to IMPα1, rhythmic behavior and nuclear expression of PER-TIM require a specific nuclear pore protein, Nup153, and Ran-GTPase. IMPα1 can also drive rapid and efficient nuclear expression of TIM and PER in cultured cells, although the effect on PER is mediated by TIM. Mapping of interaction domains between IMPα1 and TIM/PER suggests that TIM is the primary cargo for the importin machinery. This is supported by attenuated interaction of IMPα1 with TIM carrying a mutation previously shown to prevent nuclear entry of TIM and PER. TIM is detected at the nuclear envelope, and computational modeling suggests that it contains HEAT-ARM repeats typically found in karyopherins, consistent with its role as a co-transporter for PER. These findings suggest that although PER is the major timekeeper of the clock, TIM is the primary target of nuclear import mechanisms. Thus, the circadian clock uses specific components of the importin pathway with a novel twist in that TIM serves a karyopherin-like role for PER.

Meyer, Prof. Kurt H.

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1952 Honorary. Meyer, Prof. Kurt H. Date of birth: 29 September 1883. Date of death: 14 April 1952. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held from ...

Engstrom, Prof. Arne Vilhelm

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1970 Honorary. Engstrom, Prof. Arne Vilhelm. Date of birth: 15 May 1920. Date of death: 19 July 1996. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held from ...

Awards: New Year Knighthood for Tim Berners-Lee

CERN Multimedia

2004-01-01

Tim Berners-Lee has been awarded his country's highest honour - a knighthood - in the UK's New Year Honours list for his work while at CERN on the World Wide Web. In the same honours list, Roger Cashmore has been made a Companion of the Order of St Michael and St George (CMG) "for his services to international co-operation in particle physics". Cashmore was CERN's Director for Collider Programmes from 1999-2003, and is now Principal of Brasenose College, Oxford. Tim Berners-Lee stands in front of the first web server at Palexpo during the World Summit on the Information Society.

Tim Berners-Lee at the RSIS conference from 8-9 December 2003.

CERN Multimedia

Patrice Loiez

2003-01-01

Tim Berners-Lee participated in the Role of Science in the Information Society conference held at CERN from 8-9 December 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Krishna Murty, Prof. Achyutuni Venkata

Indian Academy of Sciences (India)

Fellow Profile. Elected: 1993 Section: Engineering & Technology. Krishna Murty, Prof. Achyutuni Venkata Ph.D. (IISc). Date of birth: 10 October 1938. Specialization: Aerospace Engineering, Structural Mechanics, Composites and Smart Structures Address: No. 8, 5th Main, II Cross, NTI Layout, RMV II Stage, Nagashettyhalli, ...

Valiathan, Prof. Marthanda Varma Sankaran

Indian Academy of Sciences (India)

Valiathan, Prof. Marthanda Varma Sankaran Ch.M. (Liverpool), FRCS (England, Edinburgh & Canada), FRCP (London), D.Sc. (h.c.), FNA, FNASc, FNAE, FAMS, FTWAS Council Service: 1980-91; Vice-President: 1986-91. Date of birth: 24 May 1934. Specialization: Cardiac Surgery, Cardiovascular Materials and Ayurveda

Mohan Ram, Prof. Holenarasipur Yoganarasimham

Indian Academy of Sciences (India)

Mohan Ram, Prof. Holenarasipur Yoganarasimham Ph.D. (Delhi), FNA, FNASc, FNAAS Council Service: 1983-88; Vice-President: 1986-88. Date of birth: 24 September 1930. Specialization: Plant Growth & Development and Economic Botany Address: No. 174, SFS DDA Flats, Mukherjee Nagar, Delhi 110 009, U.T.

TIM, a ray-tracing program for METATOY research and its dissemination

Science.gov (United States)

Lambert, Dean; Hamilton, Alasdair C.; Constable, George; Snehanshu, Harsh; Talati, Sharvil; Courtial, Johannes

2012-03-01

TIM (The Interactive METATOY) is a ray-tracing program specifically tailored towards our research in METATOYs, which are optical components that appear to be able to create wave-optically forbidden light-ray fields. For this reason, TIM possesses features not found in other ray-tracing programs. TIM can either be used interactively or by modifying the openly available source code; in both cases, it can easily be run as an applet embedded in a web page. Here we describe the basic structure of TIM's source code and how to extend it, and we give examples of how we have used TIM in our own research. Program summaryProgram title: TIM Catalogue identifier: AEKY_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKY_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 124 478 No. of bytes in distributed program, including test data, etc.: 4 120 052 Distribution format: tar.gz Programming language: Java Computer: Any computer capable of running the Java Virtual Machine (JVM) 1.6 Operating system: Any; developed under Mac OS X Version 10.6 RAM: Typically 145 MB (interactive version running under Mac OS X Version 10.6) Classification: 14, 18 External routines: JAMA [1] (source code included) Nature of problem: Visualisation of scenes that include scene objects that create wave-optically forbidden light-ray fields. Solution method: Ray tracing. Unusual features: Specifically designed to visualise wave-optically forbidden light-ray fields; can visualise ray trajectories; can visualise geometric optic transformations; can create anaglyphs (for viewing with coloured "3D glasses") and random-dot autostereograms of the scene; integrable into web pages. Running time: Problem-dependent; typically seconds for a simple scene.

Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4.

Science.gov (United States)

Tietjen, Gregory T; Gong, Zhiliang; Chen, Chiu-Hao; Vargas, Ernesto; Crooks, James E; Cao, Kathleen D; Heffern, Charles T R; Henderson, J Michael; Meron, Mati; Lin, Binhua; Roux, Benot; Schlossman, Mark L; Steck, Theodore L; Lee, Ka Yee C; Adams, Erin J

2014-04-15

Recognition of phosphatidylserine (PS) lipids exposed on the extracellular leaflet of plasma membranes is implicated in both apoptotic cell removal and immune regulation. The PS receptor T cell immunoglobulin and mucin-domain-containing molecule 4 (Tim4) regulates T-cell immunity via phagocytosis of both apoptotic (high PS exposure) and nonapoptotic (intermediate PS exposure) activated T cells. The latter population must be removed at lower efficiency to sensitively control immune tolerance and memory cell population size, but the molecular basis for how Tim4 achieves this sensitivity is unknown. Using a combination of interfacial X-ray scattering, molecular dynamics simulations, and membrane binding assays, we demonstrate how Tim4 recognizes PS in the context of a lipid bilayer. Our data reveal that in addition to the known Ca(2+)-coordinated, single-PS binding pocket, Tim4 has four weaker sites of potential ionic interactions with PS lipids. This organization makes Tim4 sensitive to PS surface concentration in a manner capable of supporting differential recognition on the basis of PS exposure level. The structurally homologous, but functionally distinct, Tim1 and Tim3 are significantly less sensitive to PS surface density, likely reflecting the differences in immunological function between the Tim proteins. These results establish the potential for lipid membrane parameters, such as PS surface density, to play a critical role in facilitating selective recognition of PS-exposing cells. Furthermore, our multidisciplinary approach overcomes the difficulties associated with characterizing dynamic protein/membrane systems to reveal the molecular mechanisms underlying Tim4's recognition properties, and thereby provides an approach capable of providing atomic-level detail to uncover the nuances of protein/membrane interactions.

Rees, Prof. Lord Martin (John)

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1991 Honorary. Rees, Prof. Lord Martin (John) FRS. Date of birth: 23 June 1942. Address: Emeritus professor of Cosmology & Astrophysics, Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA, U.K.. Contact: Office: (+44-1223) 33 7548

Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3).

Science.gov (United States)

Homayouni, Vida; Ganjalikhani-Hakemi, Mazdak; Rezaei, Abbas; Khanahmad, Hossein; Behdani, Mahdi; Lomedasht, Fatemeh Kazemi

2016-11-01

As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. We immunized a camel with TIM-3 antigen and then, synthesized a VHH phage: mid library from its B cell's transcriptome using nested PCR. Library selection against TIM-3antigen was performed in three rounds of panning. Using phage-ELISA, the most reactive colonies were selected for sub-cloning in soluble protein expression vectors. The Nanobody was purified and confirmed with a nickel-nitrilotriacetic acid (Ni-NTA) column, SDS-PAGE and Western blotting. A flowcytometric analysis was performed to analyze the binding and biologic activities of theTIM-3 specific nanobody with TIM-3 expressing HL-60 and HEK cell lines. Specific 15kD band representing for nanobody was observed on the gel and confirmed with Western blotting. The nanobody showed significant specific immune-reactivity against TIM-3 with a relatively high binding affinity. The nanobody significantly suppressed the proliferation of TIM-3 expressing HL-60 cell line. Finally, we successfully prepared a functional anti-humanTIM-3 specific nanobody with a high affinity and an anti-proliferative activity on an AML cell line in vitro.

Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3

Directory of Open Access Journals (Sweden)

Vida Homayouni

2016-11-01

Full Text Available Objective(s: As T-cell immunoglobulin and mucin domain 3 (TIM-3 is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. Materials and Methods:We immunized a camel with TIM-3 antigen and then, synthesized a VHH phagemid library from its B cell’s transcriptome using nested PCR. Library selection against TIM-3antigen was performed in three rounds of panning. Using phage-ELISA, the most reactive colonies were selected for sub-cloning in soluble protein expression vectors. The Nanobody was purified and confirmed with a nickel-nitrilotriacetic acid (Ni-NTA column, SDS-PAGE and Western blotting. A flowcytometric analysis was performed to analyze the binding and biologic activities of theTIM-3 specific nanobody with TIM-3 expressing HL-60 and HEK cell lines. Results:Specific 15kD band representing for nanobody was observed on the gel and confirmed with Western blotting. The nanobody showed significant specific immune-reactivity against TIM-3 with a relatively high binding affinity. The nanobody significantly suppressed the proliferation of TIM-3 expressing HL-60 cell line. Conclusion: Finally, we successfully prepared a functional anti-humanTIM-3 specific nanobody with a high affinity and an anti-proliferative activity on an AML cell line in vitro.

Prof. John Wood, Chief Executive Designate, Dr Gordon Walker, Directorate, Chief Executive, Prof. Ken J. Peach, Head of the Particle Physics Department, CLRC Rutherford Appleton Laboratory, United Kingdom

CERN Multimedia

Patrice Loïez

2001-01-01

L. to. r.: Dr. Ian Wilson, CLIC Deputy Study Leader, Prof. Ken J. Peach, Head of the Particle Physics Department, Prof. John Wood, Chief Executive Designate, Dr. Gordon Walker, Directorate, Chief Executive

A polymorphism of the TIM-1 IgV domain: implications for the susceptibility to filovirus infection.

Science.gov (United States)

Kuroda, Makoto; Fujikura, Daisuke; Noyori, Osamu; Kajihara, Masahiro; Maruyama, Junki; Miyamoto, Hiroko; Yoshida, Reiko; Takada, Ayato

2014-12-12

Filoviruses, including Ebola and Marburg viruses, cause severe hemorrhagic fever in humans and nonhuman primates with mortality rates of up to 90%. Human T-cell immunoglobulin and mucin domain 1 (TIM-1) is one of the host proteins that have been shown to promote filovirus entry into cells. In this study, we cloned TIM-1 genes from three different African green monkey kidney cell lines (Vero E6, COS-1, and BSC-1) and found that TIM-1 of Vero E6 had a 23-amino acid deletion and 6 amino acid substitutions compared with those of COS-1 and BSC-1. Interestingly, Vero E6 TIM-1 had a greater ability to promote the infectivity of vesicular stomatitis viruses pseudotyped with filovirus glycoproteins than COS-1-derived TIM-1. We further found that the increased ability of Vero E6 TIM-1 to promote virus infectivity was most likely due to a single amino acid difference between these TIM-1s. These results suggest that a polymorphism of the TIM-1 molecules is one of the factors that influence cell susceptibility to filovirus infection, providing a new insight into the molecular basis for the filovirus host range. Copyright © 2014 Elsevier Inc. All rights reserved.

Airborne Thermal Infrared Multispectral Scanner (TIMS) images over disseminated gold deposits, Osgood Mountains, Humboldt County, Nevada

Science.gov (United States)

Krohn, M. Dennis

1986-01-01

The U.S. Geological Survey (USGS) acquired airborne Thermal Infrared Multispectral Scanner (TIMS) images over several disseminated gold deposits in northern Nevada in 1983. The aerial surveys were flown to determine whether TIMS data could depict jasperoids (siliceous replacement bodies) associated with the gold deposits. The TIMS data were collected over the Pinson and Getchell Mines in the Osgood Mountains, the Carlin, Maggie Creek, Bootstrap, and other mines in the Tuscarora Mountains, and the Jerritt Canyon Mine in the Independence Mountains. The TIMS data seem to be a useful supplement to conventional geochemical exploration for disseminated gold deposits in the western United States. Siliceous outcrops are readily separable in the TIMS image from other types of host rocks. Different forms of silicification are not readily separable, yet, due to limitations of spatial resolution and spectral dynamic range. Features associated with the disseminated gold deposits, such as the large intrusive bodies and fault structures, are also resolvable on TIMS data. Inclusion of high-resolution thermal inertia data would be a useful supplement to the TIMS data.

Prof. Manfred Popp, Chairman of the Executive Board, Forschungszentrum Karlsruhe GmbH

CERN Multimedia

Patrice Loïez

2003-01-01

Prof. Popp is pictured here in the ATLAS detector assembly hall with Dr. Horst Wenninger of CERN.Photo 01: Prof. Popp (right) and Dr. Wenninger in front of one of the two vacuum vessels for the ATLAS end-cap toroid magnets.Photo 02: Prof. Popp (right) and Dr. Wenninger in front of one of eight 25-metre-long aluminium-alloy coil casings that will house the racetrack coils of the barrel toroid magnet system.

Traditional Indian medicine (TIM) and traditional Korean medicine (TKM): aconstitutional-based concept and comparison.

Science.gov (United States)

Kang, Young Min; Komakech, Richard; Karigar, Chandrakant Shivappa; Saqib, Asma

2017-06-01

Traditional and complementary medicine (T&CM) plays an integral role in providing health care worldwide. It is based on sound fundamental principles and centuries of practices. This study compared traditional Indian medicine (TIM) and traditional Korean medicine (TKM) basing on data obtained from peer reviewed articles, respective government institutional reports and World Health Organization reports. Despite the fact that TIM and TKM have individual qualities that are unique from each other including different histories of origin, they share a lot in common. Apart from Homeopathy in TIM, both systems are hinged on similar principle of body constitutional-based concept and similar disease diagnosis methods of mainly auscultation, palpation, visual inspection, and interrogation. Similarly, the treatment methods of TIM and TKM follow similar patterns involving use of medicinal herbs, moxibustion, acupuncture, cupping, and manual therapy. Both T&CM are majorly practiced in well-established hospitals by T&CM doctors who have undergone an average of 6-7 years of specialized trainings. However, unlike TIM which has less insurance coverage, the popularity of TKM is majorly due to its wide national insurance coverage. These two medical traditions occupy increasingly greater portion of the global market. However, TIM especially Ayurveda has gained more global recognition than TKM although the emergence of Sasang Constitutional Medicine in TKM is beginning to become more popular. This comparative analysis between TIM and TKM may provide vital and insightful contribution towards constitutional-based concept for further development and future studies in T&CM.

Meet EPA Scientist Tim Shafer, Ph.D.

Science.gov (United States)

Tim Shafer earned his bachelor’s degree in biology and chemistry from Hope College in Holland, MI, in 1986 and his Ph.D. in pharmacology and environmental toxicology from Michigan State University in 1991.

Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

Energy Technology Data Exchange (ETDEWEB)

Cai, X.Z. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang (China); Huang, W.Y.; Qiao, Y.; Chen, Y.; Du, S.Y.; Chen, D.; Yu, S. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Liu, N. [Department of Nephrology, First Affiliated Hospital, China Medical University, Shenyang (China); Dou, L.Y. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Jiang, Y. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang (China); Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang (China)

2014-10-17

The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients compared with healthy controls (P<0.001). No significant differences in TIM family protein expression were observed in leukocytes from SLE patients and healthy controls (P>0.05). SLE patients with lupus nephritis (LN) had a significantly lower expression of TIM-3 mRNA than those without LN (P=0.001). There was no significant difference in the expression of TIM-3 mRNA within different classes of LN (P>0.05). Correlation of TIM-3 mRNA expression with serum IgA was highly significant (r=0.425, P=0.004), but was weakly correlated with total serum protein (r{sub s}=0.283, P=0.049) and serum albumin (r{sub s}=0.297, P=0.047). TIM-3 mRNA expression was weakly correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; r{sub s}=-0.272, P=0.032). Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE.

Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

International Nuclear Information System (INIS)

Cai, X.Z.; Huang, W.Y.; Qiao, Y.; Chen, Y.; Du, S.Y.; Chen, D.; Yu, S.; Liu, N.; Dou, L.Y.; Jiang, Y.

2014-01-01

The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients compared with healthy controls (P<0.001). No significant differences in TIM family protein expression were observed in leukocytes from SLE patients and healthy controls (P>0.05). SLE patients with lupus nephritis (LN) had a significantly lower expression of TIM-3 mRNA than those without LN (P=0.001). There was no significant difference in the expression of TIM-3 mRNA within different classes of LN (P>0.05). Correlation of TIM-3 mRNA expression with serum IgA was highly significant (r=0.425, P=0.004), but was weakly correlated with total serum protein (r s =0.283, P=0.049) and serum albumin (r s =0.297, P=0.047). TIM-3 mRNA expression was weakly correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; r s =-0.272, P=0.032). Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE

Patel, Prof. Chandra Kumar Naranbhai

Indian Academy of Sciences (India)

Elected: 1995 Honorary. Patel, Prof. Chandra Kumar Naranbhai. Date of birth: 2 July 1938. Address: President & CEO, Pranalytica Inc., 1101, Colorado Avenue, Santa Monica, CA 90401, U.S.A.. Contact: Office: (+1-310) 458 0808. Residence: (+1-310) 471 6505. Fax: (+1-310) 458 0171. Email: patel@pranalytica.com.

Geim, Prof. Sir Andre Konstantin

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.

Science.gov (United States)

Du, Xianhong; Wu, Zhuanchang; Xu, Yong; Liu, Yuan; Liu, Wen; Wang, Tixiao; Li, Chunyang; Zhang, Cuijuan; Yi, Fan; Gao, Lifen; Liang, Xiaohong; Ma, Chunhong

2018-05-07

As an immune checkpoint, Tim-3 plays roles in the regulation of both adaptive and innate immune cells including macrophages and is greatly involved in chronic liver diseases. However, the precise roles of Tim-3 in nonalcoholic steatohepatitis (NASH) remain unstated. In the current study, we analyzed Tim-3 expression on different subpopulations of liver macrophages and further investigated the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice. The results of flow cytometry demonstrated the significantly increased expression of Tim-3 on all detected liver macrophage subsets in MCD mice, including F4/80 + CD11b + , F4/80 + CD68 + , and F4/80 + CD169 + macrophages. Remarkably, Tim-3 knockout (KO) significantly accelerated MCD-induced liver steatosis, displaying higher serum ALT, larger hepatic vacuolation, more liver lipid deposition, and more severe liver fibrosis. Moreover, compared with wild-type C57BL/6 mice, Tim-3 KO MCD mice demonstrated an enhanced expression of NOX2, NLRP3, and caspase-1 p20 together with increased generation of IL-1β and IL-18 in livers. In vitro studies demonstrated that Tim-3 negatively regulated the production of reactive oxygen species (ROS) and related downstream pro-inflammatory cytokine secretion of IL-1β and IL-18 in macrophages. Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1β and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD. In conclusion, Tim-3 is a promising protector in MCD-induced steatohepatitis by controlling ROS and the associated pro-inflammatory cytokine production in macrophages.

Academic training: Advanced lectures on multiprocessor programming

CERN Multimedia

PH Department

2011-01-01

Academic Training Lecture - Regular Programme 31 October 1, 2 November 2011 from 11:00 to 12:00 -  IT Auditorium, Bldg. 31   Three classes (60 mins) on Multiprocessor Programming Prof. Dr. Christoph von Praun Georg-Simon-Ohm University of Applied Sciences Nuremberg, Germany This is an advanced class on multiprocessor programming. The class gives an introduction to principles of concurrent objects and the notion of different progress guarantees that concurrent computations can have. The focus of this class is on non-blocking computations, i.e. concurrent programs that do not make use of locks. We discuss the implementation of practical non-blocking data structures in detail. 1st class: Introduction to concurrent objects 2nd class: Principles of non-blocking synchronization 3rd class: Concurrent queues Brief Bio of Christoph von Praun Christoph worked on a variety of analysis techniques and runtime platforms for parallel programs. Hist most recent research studies programming models an...

Thomas, Prof. Sir John Meurig

Indian Academy of Sciences (India)

Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.

Traditional Indian medicine (TIM and traditional Korean medicine (TKM: aconstitutional-based concept and comparison

Directory of Open Access Journals (Sweden)

Young Min Kang

2017-06-01

Full Text Available Traditional and complementary medicine (T&CM plays an integral role in providing health care worldwide. It is based on sound fundamental principles and centuries of practices. This study compared traditional Indian medicine (TIM and traditional Korean medicine (TKM basing on data obtained from peer reviewed articles, respective government institutional reports and World Health Organization reports. Despite the fact that TIM and TKM have individual qualities that are unique from each other including different histories of origin, they share a lot in common. Apart from Homeopathy in TIM, both systems are hinged on similar principle of body constitutional-based concept and similar disease diagnosis methods of mainly auscultation, palpation, visual inspection, and interrogation. Similarly, the treatment methods of TIM and TKM follow similar patterns involving use of medicinal herbs, moxibustion, acupuncture, cupping, and manual therapy. Both T&CM are majorly practiced in well-established hospitals by T&CM doctors who have undergone an average of 6–7 years of specialized trainings. However, unlike TIM which has less insurance coverage, the popularity of TKM is majorly due to its wide national insurance coverage. These two medical traditions occupy increasingly greater portion of the global market. However, TIM especially Ayurveda has gained more global recognition than TKM although the emergence of Sasang Constitutional Medicine in TKM is beginning to become more popular. This comparative analysis between TIM and TKM may provide vital and insightful contribution towards constitutional-based concept for further development and future studies in T&CM.

Dirac, Prof. Paul Adrien Maurice

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Dirac, Prof. Paul Adrien Maurice Nobel Laureate (Physics) - 1933. Date of birth: 8 August 1902. Date of death: 20 October 1984. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Patel, Prof. Chandra Kumar Naranbhai

Indian Academy of Sciences (India)

Patel, Prof. Chandra Kumar Naranbhai. Date of birth: 2 July 1938. Address: President & CEO, Pranalytica Inc., 1101, Colorado Avenue, Santa Monica, CA 90401, U.S.A.. Contact: Office: (+1-310) 458 0808. Residence: (+1-310) 471 6505. Fax: (+1-310) 458 0171. Email: patel@pranalytica.com. YouTube · Twitter · Facebook ...

Broglie, Prof. Louis Victor de

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1951 Honorary. Broglie, Prof. Louis Victor de. Nobel Laureate (Physics) - 1929. Date of birth: 15 August 1892. Date of death: 19 March 1987. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Thermal ionisation mass spectrometry (TIMS): what, how and why?

International Nuclear Information System (INIS)

Aggarwal, S.K.

2002-01-01

Thermal ionisation mass spectrometry (TIMS) is one of the oldest mass spectrometric techniques, which has been used for determining the isotopic composition and concentration of different elements using isotope dilution. In spite of the introduction of many other inorganic mass spectrometric techniques like spark source mass spectrometry (SSMS), glow discharge mass spectrometry (GDMS), inductively coupled plasma-mass spectrometry (ICP-MS), secondary ion mass spectrometry (SIMS), the TIMS technique plays the role of a definitive analytical methodology and still occupies a unique position in terms of its capabilities with respect to precision and accuracy as well as sensitivity

Isotopic Ratios of Samarium by TIMS for Nuclear Forensic Application

Energy Technology Data Exchange (ETDEWEB)

Louis Jean, James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Inglis, Jeremy David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-08-08

The isotopic ratio of Nd, Sm, and Gd can provide important information regarding fissile material (nuclear devices, reactors), neutron environment, and device yield. These studies require precise measurement of Sm isotope ratios, by either TIMS or MC-ICP-MS. There has been an increasing trend to measure smaller and smaller quantities of Sm bearing samples. In nuclear forensics 10-100 ng of Sm are needed for precise measurement. To measure sub-ng Sm samples using TIMS for nuclear forensic analysis.

King, Prof. Sir David Anthony

Indian Academy of Sciences (India)

Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

Novel effector phenotype of Tim-3+ regulatory T cells leads to enhanced suppressive function in head and neck cancer patients.

Science.gov (United States)

Liu, Zhuqing; McMichael, Elizabeth L; Shayan, Gulidanna; Li, Jing; Chen, Kevin; Srivastava, Raghvendra M; Kane, Lawrence P; Lu, Binfeng; Ferris, Robert L

2018-04-30

Regulatory T (Treg) cells are important suppressive cells among tumor infiltrating lymphocytes (TIL). Treg express the well-known immune checkpoint receptor PD-1, which is reported to mark "exhausted" Treg with lower suppressive function. T cell immunoglobulin mucin (Tim)-3, a negative regulator of Th1 immunity, is expressed by a sizeable fraction of TIL Tregs, but the functional status of Tim-3+ Tregs remains unclear. CD4+CTLA-4+CD25high Treg were sorted from freshly excised head and neck squamous cell carcinoma (HNSCC) TIL based on Tim-3 expression. Functional and phenotypic features of these Tim-3+ and Tim-3- TIL Tregs were tested by in vitro suppression assays and multi-color flow cytometry. Gene expression profiling and NanoString analysis of Tim-3+ TIL Treg were performed. A murine HNSCC tumor model was used to test the effect of anti-PD-1 immunotherapy on Tim-3+ Treg.  Results: Despite high PD-1 expression, Tim-3+ TIL Treg displayed a greater capacity to inhibit naïve T cell proliferation than Tim-3- Treg. Tim-3+ Treg from human HNSCC TIL also displayed an effector-like phenotype, with more robust expression of CTLA-4, PD-1, CD39 and IFN-γ receptor. Exogenous IFN-γ treatment could partially reverse the suppressive function of Tim-3+ TIL Treg. Anti-PD-1 immunotherapy downregulated Tim-3 expression on Tregs isolated from murine HNSCC tumors, and this treatment reversed the suppressive function of HNSCC TIL Tregs. Tim-3+ Treg are functionally and phenotypically distinct in HNSCC TIL, and are highly effective at inhibiting T cell proliferation despite high PD-1 expression.  IFN-γ induced by anti-PD-1 immunotherapy may be beneficial by reversing Tim-3+ Treg suppression. Copyright ©2018, American Association for Cancer Research.

Tim Berners-Lee, World Wide Web inventor

CERN Multimedia

1998-01-01

The "Internet, Web, What's next?" conference on 26 June 1998 at CERN: Tim Berners-Lee, inventor of the World Wide Web and Director of the W3C, explains how the Web came to be and gave his views on the future.

Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS

Science.gov (United States)

Garabedian, Alyssa; Benigni, Paolo; Ramirez, Cesar E.; Baker, Erin S.; Liu, Tao; Smith, Richard D.; Fernandez-Lima, Francisco

2017-09-01

In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150-250) prior to mass analysis. Five peptide biomarkers were separated, identified, and quantified using offline nanoESI-TIMS-CID-TOF MS; the results were in good agreement with measurements using a traditional LC-ESI-MS/MS proteomics workflow. The TIMS-TOF MS analysis permitted peptide biomarker detection based on accurate mobility, mass measurements, and high sequence coverage for concentrations in the 10-200 nM range, while simultaneously achieving discovery measurements of not initially targeted peptides as markers from the same proteins and, eventually, other proteins. [Figure not available: see fulltext.

Sopory, Prof. Sudhir Kumar - IAS Fellow

Indian Academy of Sciences (India)

Elected: 1992 Section: Plant Sciences. Sopory, Prof. Sudhir Kumar Ph.D. (Delhi), FNA, FNASc, FNAAS, FTWAS Council Service: 2001-2006. Date of birth: 7 January 1948. Specialization: Molecular Plant Physiology and Plant Tissue Culture & Transformation Address: 584, Sector 14, Faridabad 121 007, Haryana Contact:

TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity

Science.gov (United States)

Angiari, Stefano; Donnarumma, Tiziano; Rossi, Barbara; Dusi, Silvia; Pietronigro, Enrica; Zenaro, Elena; Della Bianca, Vittorina; Toffali, Lara; Piacentino, Gennj; Budui, Simona; Rennert, Paul; Xiao, Sheng; Laudanna, Carlo; Casasnovas, Jose M.; Kuchroo, Vijay K.; Constantin, Gabriela

2014-01-01

SUMMARY Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rolling of T helper-1 (Th1) and Th17, but not Th2 and regulatory T cells on P-selectin. Th1 and Th17 cells lacking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inflamed brain microcirculation. Inhibition of TIM-1 had no effect on naive T cell homing, but reduced T cell recruitment in a skin hypersensitivity model and blocked experimental autoimmune encephalomyelitis. Uniquely, the TIM-1 IgV domain was also required for P-selectin binding. Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease. PMID:24703780

van den Heuvel, Prof. Edward P J

Indian Academy of Sciences (India)

van den Heuvel, Prof. Edward P J . Date of birth: 2 November 1940. Address: Professor of Astrophysics, Astronomical Inst. Anton Pannekoek, Postbus 94249, 1090 GE Amsterdam, The Netherlands Contact: Office: (+31-20) 525 ...

Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

Science.gov (United States)

Nozaki, Yuji; Nikolic-Paterson, David J; Snelgrove, Sarah L; Akiba, Hisaya; Yagita, Hideo; Holdsworth, Stephen R; Kitching, A Richard

2012-05-01

The T-cell immunoglobulin mucin 1 (Tim-1) modulates CD4(+) T-cell responses and is also expressed by damaged proximal tubules in the kidney where it is known as kidney injury molecule-1 (Kim-1). We sought to define the role of endogenous Tim-1 in experimental T-cell-mediated glomerulonephritis induced by sheep anti-mouse glomerular basement membrane globulin acting as a planted foreign antigen. Tim-1 is expressed by infiltrating activated CD4(+) cells in this model, and we studied the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) on immune responses and glomerular disease. Crescentic glomerulonephritis, proliferative injury, and leukocyte accumulation were attenuated following treatment with anti-Tim-1 antibodies, but interstitial foxp3(+) cell accumulation and interleukin-10 mRNA were increased. T-cell proliferation and apoptosis decreased in the immune system along with a selective reduction in Th1 and Th17 cellular responses both in the immune system and within the kidney. The urinary excretion and renal expression of Kim-1 was reduced by anti-Tim-1 antibodies reflecting diminished interstitial injury. The effects of anti-Tim-1 antibodies were not apparent in the early phase of renal injury, when the immune response to sheep globulin was developing. Thus, endogenous Tim-1 promotes Th1 and Th17 nephritogenic immune responses and its neutralization reduces renal injury while limiting inflammation in cell-mediated glomerulonephritis.

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry.

Science.gov (United States)

Rhein, Bethany A; Brouillette, Rachel B; Schaack, Grace A; Chiorini, John A; Maury, Wendy

2016-07-01

Phosphatidylserine (PtdSer) receptors that are responsible for the clearance of dying cells have recently been found to mediate enveloped virus entry. Ebola virus (EBOV), a member of the Filoviridae family of viruses, utilizes PtdSer receptors for entry into target cells. The PtdSer receptors human and murine T-cell immunoglobulin mucin (TIM) domain proteins TIM-1 and TIM-4 mediate filovirus entry by binding to PtdSer on the virion surface via a conserved PtdSer binding pocket within the amino-terminal IgV domain. While the residues within the TIM-1 IgV domain that are important for EBOV entry are characterized, the molecular details of virion-TIM-4 interactions have yet to be investigated. As sequences and structural alignments of the TIM proteins suggest distinct differences in the TIM-1 and TIM-4 IgV domain structures, we sought to characterize TIM-4 IgV domain residues required for EBOV entry. Using vesicular stomatitis virus pseudovirions bearing EBOV glycoprotein (EBOV GP/VSVΔG), we evaluated virus binding and entry into cells expressing TIM-4 molecules mutated within the IgV domain, allowing us to identify residues important for entry. Similar to TIM-1, residues in the PtdSer binding pocket of murine and human TIM-4 (mTIM-4 and hTIM-4) were found to be important for EBOV entry. However, additional TIM-4-specific residues were also found to impact EBOV entry, with a total of 8 mTIM-4 and 14 hTIM-4 IgV domain residues being critical for virion binding and internalization. Together, these findings provide a greater understanding of the interaction of TIM-4 with EBOV virions. With more than 28,000 cases and over 11,000 deaths during the largest and most recent Ebola virus (EBOV) outbreak, there has been increased emphasis on the development of therapeutics against filoviruses. Many therapies under investigation target EBOV cell entry. T-cell immunoglobulin mucin (TIM) domain proteins are cell surface factors important for the entry of many enveloped viruses

Economist Innovation Award for Tim Berners-Lee

CERN Multimedia

2003-01-01

In September, Tim Berners-Lee, who invented the World Wide Web at CERN and is now Director of the W3C World Wide Web Consortium, received the 2nd Economist Annual Innovation Award in Computing. With the award The Economist, a British weekly newspaper, recognises individuals responsible for breakthroughs in Bioscience, Computing, Energy and the Environment, and Telecommunications that have a profound impact on industry. A fifth award is given in a special "No Boundaries" category, observing innovation that transcends industries. Candidates for the awards are proposed by The Economist readers and writers, and by a group of judges. Tim Berners-Lee received the Computing award for his global hypertext project, to be known as the World Wide Web, which "forever altered the way information is shared" and is a huge contribution to the efficiency of the scientific community. Based on a programme for storing information using random associations called "Enquire", it...

Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria.

Science.gov (United States)

Popov-Celeketić, Dusan; Mapa, Koyeli; Neupert, Walter; Mokranjac, Dejana

2008-05-21

The TIM23 (translocase of the mitochondrial inner membrane) complex mediates translocation of preproteins across and their insertion into the mitochondrial inner membrane. How the translocase mediates sorting of preproteins into the two different subcompartments is poorly understood. In particular, it is not clear whether association of two operationally defined parts of the translocase, the membrane-integrated part and the import motor, depends on the activity state of the translocase. We established conditions to in vivo trap the TIM23 complex in different translocation modes. Membrane-integrated part of the complex and import motor were always found in one complex irrespective of whether an arrested preprotein was present or not. Instead, we detected different conformations of the complex in response to the presence and, importantly, the type of preprotein being translocated. Two non-essential subunits of the complex, Tim21 and Pam17, modulate its activity in an antagonistic manner. Our data demonstrate that the TIM23 complex acts as a single structural and functional entity that is actively remodelled to sort preproteins into different mitochondrial subcompartments.

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.

Directory of Open Access Journals (Sweden)

Brian Tomkowicz

Full Text Available TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3 is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells. Recent studies indicate that TIM-3 serves as a negative regulator of T cell function (i.e. T cell dependent immune responses, proliferation, tolerance, and exhaustion. Despite having no recognizable inhibitory signaling motifs, the intracellular tail of TIM-3 is apparently indispensable for function. Specifically, the conserved residues Y265/Y272 and surrounding amino acids appear to be critical for function. Mechanistically, several studies suggest that TIM-3 can associate with interleukin inducible T cell kinase (ITK, the Src kinases Fyn and Lck, and the p85 phosphatidylinositol 3-kinase (PI3K adaptor protein to positively or negatively regulate IL-2 production via NF-κB/NFAT signaling pathways. To begin to address this discrepancy, we examined the effect of TIM-3 in two model systems. First, we generated several Jurkat T cell lines stably expressing human TIM-3 or murine CD28-ECD/human TIM-3 intracellular tail chimeras and examined the effects that TIM-3 exerts on T cell Receptor (TCR-mediated activation, cytokine secretion, promoter activity, and protein kinase association. In this model, our results demonstrate that TIM-3 inhibits several TCR-mediated phenotypes: i NF-kB/NFAT activation, ii CD69 expression, and iii suppression of IL-2 secretion. To confirm our Jurkat cell observations we developed a primary human CD8+ cell system that expresses endogenous levels of TIM-3. Upon TCR ligation, we observed the loss of NFAT reporter activity and IL-2 secretion, and identified the association of Src kinase Lck, and PLC-γ with TIM-3. Taken together, our results support the conclusion that TIM-3 is a negative regulator of TCR-function by attenuating activation signals mediated by CD3/CD28 co-stimulation.

EDITORIAL NEWS Thank you, Prof Mollentze

African Journals Online (AJOL)

... send through a heartfelt thank you when a publication has been finalised. Prof Mollentze, we at Medpharm wish you every success on the road ahead, wherever your research interests take you. Thank you for your invaluable service to the journal, the readers, and the Medpharm team. Ina du Toit. Chief Executive Officer.

Tim de Zeeuw to Become the Next Director General of ESO

Science.gov (United States)

2007-01-01

The ESO Council has just appointed Tim de Zeeuw, 50, as the next Director General of ESO, effective as of 1 September 2007, when the current Director General, Catherine Cesarsky will complete her mandate. ESO PR Photo 02/07 ESO PR Photo 03/07 Professor Tim de Zeeuw "ESO is Europe's flagship organisation for ground-based astronomy," said, Richard Wade, President of the ESO Council. "The ESO Council is very pleased that Professor de Zeeuw has accepted the task as its next Director General. He has played a key role over the last few years in developing a strategic vision for ESO, and I have every confidence that he will now lead the organisation in the realisation of that exciting vision." Tim de Zeeuw has an excellent record, both as a highly respected scientist and as a leader of an internationally recognised science institute in the Netherlands. He is Scientific Director of the Leiden Observatory, a research institute in the College of Mathematics and Natural Sciences of Leiden University. Tim de Zeeuw also has considerable experience as regards science policy issues. Catherine Cesarsky, ESO's current Director General commented: "Over the recent years, ESO has developed considerably with more activities and new member states, and with its ambitious project portfolio, ESO is clearly facing an exciting future. I shall be delighted to pass the baton to Tim de Zeeuw, who as a recent Council member is very familiar with our Organisation." "It is a great honour and an exciting challenge to lead this world-class organisation in the years to come in support of one of the most dynamic areas of science today," said de Zeeuw. "I look forward to overseeing the continued upgrading of the Very Large Telescope with the second-generation instrumentation and the completion of the ALMA project, and in particular to help developing the future European Extremely Large Telescope." Tim de Zeeuw's main research interests embrace the formation, structure and dynamics of galaxies

My days as a student of Prof. Hao (1982-1986)

Science.gov (United States)

Ding, Mingzhou

In 1982 I graduated from Peking University with a bachelor's degree in astrophysics. Passing the entrance exam the same year I became a graduate student in the Institute of Theoretical Physics (ITP), Chinese Academy of Sciences, with Prof. Hao Bailin as my advisor. More than 30 years have gone by. I often recall the days I spent at the ITP with great fondness. Classmates have become life-long friends. The lessons we have learned from Prof. Hao about research, scholarship and life continue to influence us today...

A lecture on lecturing.

Science.gov (United States)

Calnan, J

1976-11-01

There are major differences between a lecture and a paper for publication. Often the printed word is spoken at meetings, a kind of compulsive public reading which has robbed the lecturer of the chance of oratory and the audience of a little enjoyment. The simple fact is that although doctors read aloud badly (actors do this far better) most can learn to speak spontaneolsly and with animation; but this requires time and effort, both of which are donated in a miserly way. The successful lecturer is generous and considerate of his audience--a rare being at medical meetings.

Some Components of Philosophical nature Constitutives of Prof. Mario Tourasse Teixeira’s Thought Alguns Elementos de Natureza Filosófica Constitutivos do Pensamento do Prof. Mario Tourasse Teixeira

Directory of Open Access Journals (Sweden)

Romélia Mara Alves Souto

2008-02-01

Full Text Available In this paper I endeavor to show the interest shown by Prof. Mario Tourasse Teixeira with respect to the production of mathematical knowledge and the ideas underlying the concepts of creativity in mathematics which he used and which permeate the work he supervised. My aim was to organize ideas dispersed throughout the work produced by his pupils, recorded in manuscripts or elaborated as texts and published by Prof. Tourasse in SAPO newsletters. In an attempt to capture his thoughts on Mathematics and Education, I tried to establish connections between documents which, explicitly or not, bear his mark. I believe that the merit of this effort lies in organizing, systematizing and presenting, for the first time, a draft of Prof. Mario Tourasse Teixeira’s mathematical-philosophical thought. Keywords: Mario Tourasse Teixeira. Mathematics History. Mathematics Education. History of Mathematics Education.Neste trabalho procuro mostrar o interesse que o Prof. Mario Tourasse Teixeira manifestava em relação ao dinamismo do conhecimento matemático e as idéias subjacentes ao conceito de criatividade em matemática por ele utilizado e que permeiam todos os trabalhos que orientou. Meu intuito foi organizar idéias dispersas em vários trabalhos realizados por seus alunos, registradas em alguns manuscritos ou elaboradas em textos publicados pelo Prof. Mario Tourasse, anonimamente, nos boletins do SAPO. Na tentativa de captar seu pensamento sobre Matemática e Educação, busquei estabelecer conexões entre os diversos documentos que, explicitamente ou não, guardam seu registro. Acredito que o mérito desse esforço reside em organizar, sistematizar e apresentar pela primeira vez, um esboço do pensamento matemático-filosófico do Prof. Mario Tourasse Teixeira. Palavras-chave: Mario Tourasse Teixeira. História da Matemática. Educação Matemática. História da Educação Matemática.

El De imaginibus caelestibus de Ibn al-Ḥātim

Directory of Open Access Journals (Sweden)

Oliveras, Marc

2009-06-01

Full Text Available K. Lippincott and D. Pingree published in 1987 a first Latin edition and English translation of the 15^th bilingual Arabic-Latin De imaginibus caelestibus, written originally by the Andalusian Ibn al-Ḥātim in the 10th century. The paper presented here aims to complete the preceding one with an Arabic edition, Spanish translation and some interpretations on the possible sources of talismanic imagery. In this brief astromagic treatise, Ibn al-Ḥātim focuses on twenty eight talismans, related to the lunar mansions, and their magical properties.

En 1987 K. Lippincott y D. Pingree publicaron una primera edición latina junto a una traducción inglesa del tratado bilingüe árabo-latino del s. XV De imaginibus caelestibus, escrito originariamente por el andalusí Ibn al-Ḥātim en el s. X. El trabajo que se presenta aquí pretende completar al precedente con una edición del texto árabe, su traducción al español y añadir algunas interpretaciones a las posibles fuentes de la imaginería talismánica. En este breve tratado de astromagia, Ibn al-Ḥātim se dedica principalmente a describir veintiocho talismanes, relacionados con las mansiones lunares, y sus propiedades mágicas.

T-bet-mediated Tim-3 expression dampens monocyte function during chronic hepatitis C virus infection.

Science.gov (United States)

Yi, Wenjing; Zhang, Peixin; Liang, Yan; Zhou, Yun; Shen, Huanjun; Fan, Chao; Moorman, Jonathan P; Yao, Zhi Q; Jia, Zhansheng; Zhang, Ying

2017-03-01

Hepatitis C virus (HCV) induces a high rate of chronic infection via dysregulation of host immunity. We have previously shown that T-cell immunoglobulin and mucin domain protein-3 (Tim-3) is up-regulated on monocyte/macrophages (M/Mφ) during chronic HCV infection; little is known, however, about the transcription factor that controls its expression in these cells. In this study, we investigated the role of transcription factor, T-box expressed in T cells (T-bet), in Tim-3 expression in M/Mφ in the setting of HCV infection. We demonstrate that T-bet is constitutively expressed in resting CD14 + M/Mφ in the peripheral blood. M/Mφ from chronically HCV-infected individuals exhibit a significant increase in T-bet expression that positively correlates with an increased level of Tim-3 expression. Up-regulation of T-bet is also observed in CD14 + M/Mφ incubated with HCV + Huh7.5 cells, as well as in primary M/Mφ or monocytic THP-1 cells exposed to HCV core protein in vitro, which is reversible by blocking HCV core/gC1qR interactions. Moreover, the HCV core-induced up-regulation of T-bet and Tim-3 expression in M/Mφ can be abrogated by incubating the cells with SP600125 - an inhibitor for the c-Jun N-terminal kinase (JNK) signalling pathway. Importantly, silencing T-bet gene expression decreases Tim-3 expression and enhances interleukin-12 secretion as well as signal transducer and activator of transcription 1 phosphorylation. These data suggest that T-bet, induced by the HCV core/gC1qR interaction, enhances Tim-3 expression via the JNK pathway, leading to dampened M/Mφ function during HCV infection. These findings reveal a novel mechanism for Tim-3 regulation via T-bet during HCV infection, providing new targets to combat this global epidemic viral disease. © 2016 John Wiley & Sons Ltd.

TIM1 (HAVCR1 Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

Directory of Open Access Journals (Sweden)

Anshuman Das

2017-09-01

Full Text Available Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1 is widely accepted to be the receptor for hepatitis A virus (HAV, an unusual, hepatotropic human picornavirus. However, its identification as the hepatovirus receptor predated the discovery that hepatoviruses undergo nonlytic release from infected cells as membrane-cloaked, quasi-enveloped HAV (eHAV virions that enter cells via a pathway distinct from naked, nonenveloped virions. We thus revisited the role of TIM1 in hepatovirus entry, examining both adherence and infection/replication in cells with clustered regularly interspaced short palindromic repeat (CRISPR/Cas9-engineered TIM1 knockout. Cell culture-derived, gradient-purified eHAV bound Huh-7.5 human hepatoma cells less efficiently than naked HAV at 4°C, but eliminating TIM1 expression caused no difference in adherence of either form of HAV, nor any impact on infection and replication in these cells. In contrast, TIM1-deficient Vero cells showed a modest reduction in quasi-enveloped eHAV (but not naked HAV attachment and replication. Thus, TIM1 facilitates quasi-enveloped eHAV entry in Vero cells, most likely by binding phosphatidylserine (PtdSer residues on the eHAV membrane. Both Tim1−/− Ifnar1−/− and Tim4−/− Ifnar1−/− double-knockout mice were susceptible to infection upon intravenous challenge with infected liver homogenate, with fecal HAV shedding and serum alanine aminotransferase (ALT elevations similar to those in Ifnar1−/− mice. However, intrahepatic HAV RNA and ALT elevations were modestly reduced in Tim1−/−Ifnar1−/− mice compared to Ifnar1−/− mice challenged with a lower titer of gradient-purified HAV or eHAV. We conclude that TIM1 is not an essential hepatovirus entry factor, although its PtdSer-binding activity may contribute to the spread of quasi-enveloped virus and liver injury in mice.

Exploring Tablet PC Lectures: Lecturer Experiences and Student Perceptions in Biomedicine

Science.gov (United States)

Choate, Julia; Kotsanas, George; Dawson, Phillip

2014-01-01

Lecturers using tablet PCs with specialised pens can utilise real-time changes in lecture delivery via digital inking. We investigated student perceptions and lecturer experiences of tablet PC lectures in large-enrolment biomedicine subjects. Lecturers used PowerPoint or Classroom Presenter software for lecture preparation and in-lecture pen-based…

Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS

Energy Technology Data Exchange (ETDEWEB)

Garabedian, Alyssa; Benigni, Paolo; Ramirez, Cesar; Baker, Erin M.; Liu, Tao; Smith, Richard D.; Fernandez-Lima, Francisco

2018-05-01

Abstract. In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150–250) prior to mass analysis. Five peptide biomarkers were separated, identified, and quantified using offline nanoESI-TIMSCID- TOF MS; the results were in good agreement with measurements using a traditional LC-ESI-MS/MS proteomics workflow. The TIMS-TOF MS analysis permitted peptide biomarker detection based on accurate mobility, mass measurements, and high sequence coverage for concentrations in the 10–200 nM range, while simultaneously achieving discovery measurements

Heavy metal contamination in TIMS Branch sediments

International Nuclear Information System (INIS)

Pickett, J.B.

1990-01-01

The objective of this memorandum is to summarize results of previous sediment studies on Tims Branch and Steed's Pond conducted by Health Protection (HP) and by the Savannah River Laboratory (SRL) in conjunction with Reactor Materials Engineering ampersand Technology (RMET). The results for other heavy metals, such as lead, nickel, copper, mercury, chromium, cadmium, zinc, and thorium are also summarized

Sild humanitaar- ja loodusteaduste vahel : intervjuu Aberdeeni ülikooli sotsiaalantropoloogia professori Tim Ingoldiga / Tim Ingold ; interv. Alo Joosepson, Kaie Kotov, Silver Rattasepp, Riste Keskpaik

Index Scriptorium Estoniae

Ingold, Tim

2004-01-01

4. rahvusvahelise keskkonnaesteetika ja -semiootika konverentsi "Kultuur, loodus, semiootika: kohad" üks peaesineja Tim Ingold tegeleb 1990-ndatest alates antropoloogia ja kunsti suhte uurimisega ning loeb kursust "Antropoloogia, arheoloogia, kunst ja arhitektuur"

Tim Berners-Lee: inventor de la World Wide Web

OpenAIRE

Universidad de Granada. Biblioteca

2015-01-01

El presente Cat??logo contiene la exposici??n organizada por la Biblioteca de la ETSIIT de la Universidad de Granada durante los meses de noviembre-diciembre de 2015 y titulada: "Tim Berners-Lee: inventor de la World Wide Web"

PROF-TRAC D.4.1 Overview and structure of available material

DEFF Research Database (Denmark)

Larsen, Olena Kalyanova; Heiselberg, Per Kvols

This report introduces available educational and training material from the recent IEE projects adapted in the PROF/TRAC repository. An explanation to the categorisation principle of the material in the repository is the key part of this report. The categorisation schema for educational material...... in the repository is developed using the skills and qualifications structure, developed in WP 2 of PROF/TRAC project. In this way the continuity of the work is well established and the achievements from between the work packages are harmonised....

Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins.

Science.gov (United States)

Romero-Romero, Sergio; Costas, Miguel; Rodríguez-Romero, Adela; Alejandro Fernández-Velasco, D

2015-08-28

Temperature is one of the main variables that modulate protein function and stability. Thermodynamic studies of oligomeric proteins, the dominant protein natural form, have been often hampered because irreversible aggregation and/or slow reactions are common. There are no reports on the reversible equilibrium thermal unfolding of proteins composed of (β/α)8 barrel subunits, albeit this "TIM barrel" topology is one of the most abundant and versatile in nature. We studied the eponymous TIM barrel, triosephosphate isomerase (TIM), belonging to five species of different bacterial taxa. All of them were found to be catalytically efficient dimers. The three-dimensional structure of four enzymes was solved at high/medium resolution. Irreversibility and kinetic control were observed in the thermal unfolding of two TIMs, while for the other three the thermal unfolding was found to follow a two-state equilibrium reversible process. Shifts in the global stability curves of these three proteins are related to the organismal temperature range of optimal growth and modulated by variations in maximum stability temperature and in the enthalpy change at that temperature. Reversibility appears to correlate with the low isoelectric point, the absence of a residual structure in the unfolded state, small cavity volume in the native state, low conformational stability and a low melting temperature. Furthermore, the strong coupling between dimer dissociation and monomer unfolding may reduce aggregation and favour reversibility. It is therefore very thought-provoking to find that a common topological ensemble, such as the TIM barrel, can unfold/refold in the Anfinsen way, i.e. without the help of the cellular machinery.

Lectures for CERN pensioners

CERN Multimedia

GS Department

2009-01-01

The Medical Service and the CERN and ESO Pensioners Association invite CERN pensioners to a series of presentations given by professors and specialists at the University Teaching Hospitals and the Faculty of Medicine at the University of Geneva on the subject of: PROMOTION OF OPTIMUM BRAIN AGEING The final presentation will be given in CERN’s Main Auditorium (Building 500) on: Wednesday, 25 February 2009, from 2:30 p.m. to 4:30 p.m. What is cerebral reserve ? Historique et importance de la notion de «réserve cérébrale» - Prof. Ezio GIACOBINI Intervention de la réserve cérébrale sur les troubles de la cognition - Prof. Jean-Pierre MICHEL Comment est-il possible d’évaluer la réserve cérébrale? - Prof. Gabriel GOLD Projet de recherche «Optimum Brain Ageing» - Aspects méthodologiques - Dr François HERRMANN - Aspects pratiques - Dr Dina ZEKRY The presentations will be given in French with overheads in English and will be followed by a wide-ranging disc...

Lectures for CERN pensioners

CERN Multimedia

GS Department

2009-01-01

The Medical Service and the CERN and ESO Pensioners Association invite CERN pensioners to a series of presentations given by professors and specialists at the University Teaching Hospitals and the Faculty of Medicine at the University of Geneva on the subject of: PROMOTION OF OPTIMUM BRAIN AGEING The final series of presentations will be held in CERN’s Main Auditorium (Building 500) on: Wednesday, 25 February 2009, from 2:30 p.m. to 4:30 p.m. What is cerebral reserve ? Historique et importance de la notion de «réserve cérébrale» Prof. Ezio GIACOBINI Intervention de la réserve cérébrale sur les troubles de la cognition Prof. Jean-Pierre MICHEL Comment est-il possible d’évaluer la réserve cérébrale? Prof. Gabriel GOLD Projet de recherche «Optimum Brain Ageing» - Aspects méthodologiques - Dr François HERRMANN -\tAspects pratiques - Dr Dina ZEKRY The presentations will be given in French with overheads in English and will be followed by a wide-rangin...

Interaction between Galectin-9/TIM-3 pathway and follicular helper CD4+ T cells contributes to viral persistence in chronic hepatitis C.

Science.gov (United States)

Zhuo, Ya; Zhang, Yi-Fu; Wu, Hong-Jie; Qin, Lei; Wang, Yan-Ping; Liu, A-Min; Wang, Xin-Hong

2017-10-01

Both Galectin 9 (Gal-9)/T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) pathway and follicular helper CD4 + T (Tfh) cells play important roles in persistent hepatitis C virus (HCV) infection. Thus, we aimed to investigate the regulatory role of interaction between Gal-9/TIM-3 pathway and Tfh cells in chronic hepatitis C. A total of 44 chronic hepatitis C patients and 19 normal controls (NCs) were enrolled in this study. Purified CD4 + T cells were cultured by TIM-3 Fc protein, recombinant Gal-9, or IL-21 for 48h. TIM-3 expression, Tfh proportion, and IL-21 production was measured, respectively. The immunomodulatory role of Gal-9/TIM-3 and IL-21 was also investigated in HCV cell culture system in vitro. We found that the percentage corresponding to both TIM-3-positive and CXCR5 + ICOS + Tfh cells within CD4 + T cells, which correlated with HCV RNA replication, was significantly elevated in patients with chronic hepatitis C in comparison with those in NCs. Moreover, blockade of Gal-9/TIM-3 pathway by TIM-3 Fc protein increased Tfh cells proportion, IL-21 mRNA and protein expression within purified CD4 + T cells, while activation of Gal-9/TIM-3 signaling by Gal-9 stimulation decreased IL-21 production in both patients with chronic HCV infection and healthy individuals. Meanwhile, high concentrations (100 and 200ng/mL) of IL-21 stimulation also elevated TIM-3 expression on CD4 + T cells in chronic hepatitis C. Furthermore, TIM-3 blockage and IL-21 stimulation suppressed mRNA expressions of HCV-induced antiviral proteins (myxovirus resistance A and oligoadenylate synthetase) in Huh7.5 cells without affecting viral replication in HCV cell culture system. The interaction between Gal-9/TIM-3 pathway and Tfh cells contributed to viral persistent in chronic HCV infection, which might be pivotal for development of new therapeutic approaches for chronic hepatitis C. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Upregulation of Tim-3 on CD4(+) T cells is associated with Th1/Th2 imbalance in patients with allergic asthma.

Science.gov (United States)

Tang, Fei; Wang, Fukun; An, Liyun; Wang, Xianling

2015-01-01

T cell Ig and mucin domain-containing molecule-3 (Tim-3) is a negative regulator preferentially expressed on Th1 cells. Allergic asthma is a clinical syndrome well characterized by Th1/Th2 imbalance. To investigate the role of Tim-3 in the pathogenesis of asthma and its relationship with Th1/Th2 imbalance, a total of 40 patients with allergic asthma and 40 healthy controls were enrolled. Expression of Tim-3 and Th1/Th2 imbalance as well as the relationship between them was analyzed by flow cytometry and real-time PCR. Peripheral blood mononuclear cells (PBMCs) were cultured in vitro and anti-Tim-3 was used to block Tim-3 signaling; Th1/Th2 cytokines in the culture supernatant were detected by enzyme linked immunosorbent assay (ELISA). CD4(+) T cells and B cells were sorted and co-cultured in vitro, and anti-Tim-3 was used to block Tim-3 signaling; Total IgG/IgE in the culture supernatant was detected by ELISA. The mRNA level of T-bet and IFN-γ were significantly decreased in allergic asthma patients, while GATA-3 and IL-4 were significantly increased. Expression of Tim-3 on CD4(+) T cells was much higher in allergic asthma patients and it was negatively correlated with T-bet/GATA-3 ratio or IFN-γ/IL-4 ratio. Blocking of Tim-3 significantly increased Th1 cytokines (TNF-α and IFN-γ) and decreased Th2 cytokines (IL-4, IL-5, IL-13) in the culture supernatant of PBMCs. Blocking of Tim-3 dramatically reduced the production of IgG and IgE in the co-culture supernatant of CD4(+) T cells and B cells. In conclusion, Tim-3 was up-regulated in allergic asthma patients and related with the Th1/Th2 imbalance. Blocking of Tim-3 may be of therapeutic benefit by enhancing the Th1 cytokines response, down-regulating the Th2 cytokines response, and reducing IgG/IgE production.

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions.

Science.gov (United States)

Das, Anshuman; Hirai-Yuki, Asuka; González-López, Olga; Rhein, Bethany; Moller-Tank, Sven; Brouillette, Rachel; Hensley, Lucinda; Misumi, Ichiro; Lovell, William; Cullen, John M; Whitmire, Jason K; Maury, Wendy; Lemon, Stanley M

2017-09-05

Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus. However, its identification as the hepatovirus receptor predated the discovery that hepatoviruses undergo nonlytic release from infected cells as membrane-cloaked, quasi-enveloped HAV (eHAV) virions that enter cells via a pathway distinct from naked, nonenveloped virions. We thus revisited the role of TIM1 in hepatovirus entry, examining both adherence and infection/replication in cells with clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-engineered TIM1 knockout. Cell culture-derived, gradient-purified eHAV bound Huh-7.5 human hepatoma cells less efficiently than naked HAV at 4°C, but eliminating TIM1 expression caused no difference in adherence of either form of HAV, nor any impact on infection and replication in these cells. In contrast, TIM1-deficient Vero cells showed a modest reduction in quasi-enveloped eHAV (but not naked HAV) attachment and replication. Thus, TIM1 facilitates quasi-enveloped eHAV entry in Vero cells, most likely by binding phosphatidylserine (PtdSer) residues on the eHAV membrane. Both Tim1 -/- Ifnar1 -/- and Tim4 -/- Ifnar1 -/- double-knockout mice were susceptible to infection upon intravenous challenge with infected liver homogenate, with fecal HAV shedding and serum alanine aminotransferase (ALT) elevations similar to those in Ifnar1 -/- mice. However, intrahepatic HAV RNA and ALT elevations were modestly reduced in Tim1 -/- Ifnar1 -/- mice compared to Ifnar1 -/- mice challenged with a lower titer of gradient-purified HAV or eHAV. We conclude that TIM1 is not an essential hepatovirus entry factor, although its PtdSer-binding activity may contribute to the spread of quasi-enveloped virus and liver injury in mice. IMPORTANCE T cell immunoglobulin and mucin-containing domain protein 1 (TIM1) was reported more than

Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic fatty liver disease.

Science.gov (United States)

Tang, Zhao-Hui; Liang, Shuwen; Potter, James; Jiang, Xuan; Mao, Hai-Quan; Li, Zhiping

2013-02-15

T cell Ig and mucin domain (Tim)-3 is well known to interact with its natural ligand, Galectin-9 (Gal-9), to regulate T cell function. However, little is known about the function of Tim-3/Gal-9 signaling in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) mediated by hepatic NKT cells that also express Tim-3. In the current study, we define the role and the mechanism of Tim-3/Gal-9 signaling in hepatic NKT cell regulation in a mouse model of diet-induced NAFLD. Adult male wild-type or CD1d knockout C57BL/6 mice were fed a high-fat diet to induce steatosis. Some of the mice also received one or a combination of Gal-9, anti-IL-15R/IL-15 mAb, rIL-15, α-galactosylceramide, and multilamellar liposomes containing Cl(2)MDP. The expression of Tim-3 and various markers reflecting cell proliferation, activation, cytokine production, and apoptosis was analyzed. Liver histology, steatosis grade, and hepatic triglyceride content were also evaluated. In the liver, Tim-3(+) NKT cells are in an activated state, and Gal-9 directly induces Tim-3(+) NKT cell apoptosis and contributes to the depletion of NKT cells in diet-induced steatosis. However, Gal-9 also interacts with Tim-3-expressing Kupffer cells to induce secretion of IL-15, thus promoting NKT cell proliferation. Exogenous administration of Gal-9 significantly ameliorates diet-induced steatosis by modulating hepatic NKT cell function. In summary, the Tim-3/Gal-9-signaling pathway plays a critical role in the homeostasis of hepatic NKT cells through activation-induced apoptosis and secondary proliferation and, thus, contributes to the pathogenesis of NAFLD.

Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease

Science.gov (United States)

Liang, Shuwen; Potter, James; Jiang, Xuan; Mao, Hai-Quan

2013-01-01

T cell Ig and mucin domain (Tim)-3 is well known to interact with its natural ligand, Galectin-9 (Gal-9), to regulate T cell function. However, little is known about the function of Tim-3/Gal-9 signaling in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) mediated by hepatic NKT cells that also express Tim-3. In the current study, we define the role and the mechanism of Tim-3/Gal-9 signaling in hepatic NKT cell regulation in a mouse model of diet-induced NAFLD. Adult male wild-type or CD1d knockout C57BL/6 mice were fed a high-fat diet to induce steatosis. Some of the mice also received one or a combination of Gal-9, anti–IL-15R/IL-15 mAb, rIL-15, α-galactosylceramide, and multilamellar liposomes containing Cl2MDP. The expression of Tim-3 and various markers reflecting cell proliferation, activation, cytokine production, and apoptosis was analyzed. Liver histology, steatosis grade, and hepatic triglyceride content were also evaluated. In the liver, Tim-3+ NKT cells are in an activated state, and Gal-9 directly induces Tim-3+ NKT cell apoptosis and contributes to the depletion of NKT cells in diet-induced steatosis. However, Gal-9 also interacts with Tim-3–expressing Kupffer cells to induce secretion of IL-15, thus promoting NKT cell proliferation. Exogenous administration of Gal-9 significantly ameliorates diet-induced steatosis by modulating hepatic NKT cell function. In summary, the Tim-3/Gal-9–signaling pathway plays a critical role in the homeostasis of hepatic NKT cells through activation-induced apoptosis and secondary proliferation and, thus, contributes to the pathogenesis of NAFLD. PMID:23296703

Prof. Dr. Rer. Nat. Burkhard Rauhut - Rector of RWTH Aachen University - Germany sign the golden book of the CERN. Greeting from Mr Sigurd Lettow, CERN Chief Financial Officer and Prof. Carlo Rubbia (ex CERN Director-General).

CERN Multimedia

Maximilien Brice

2007-01-01

Prof. Dr. Rer. Nat. Burkhard Rauhut - Rector of RWTH Aachen University - Germany sign the golden book of the CERN. Greeting from Mr Sigurd Lettow, CERN Chief Financial Officer and Prof. Carlo Rubbia (ex CERN Director-General).

Memory for Lectures: How Lecture Format Impacts the Learning Experience.

Science.gov (United States)

Varao-Sousa, Trish L; Kingstone, Alan

2015-01-01

The present study investigated what impact the presentation style of a classroom lecture has on memory, mind wandering, and the subjective factors of interest and motivation. We examined if having a professor lecturing live versus on video alters the learning experience of the students in the classroom. During the lectures, students were asked to report mind wandering and later complete a memory test. The lecture format was manipulated such that all the students received two lectures, one live and one a pre-recorded video. Results indicate that lecture format affected memory performance but not mind wandering, with enhanced memory in the live lectures. Additionally, students reported greater interest and motivation in the live lectures. Given that a single change to the classroom environment, professor presence, impacted memory performance, as well as motivation and interest, the present results have several key implications for technology-based integrations into higher education classrooms.

Inverse European Latitudinal Cline at the timeless Locus of Drosophila melanogaster Reveals Selection on a Clock Gene: Population Genetics of ls-tim.

Science.gov (United States)

Zonato, Valeria; Vanin, Stefano; Costa, Rodolfo; Tauber, Eran; Kyriacou, Charalambos P

2018-02-01

The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may have originated in southeastern Italy. Flies characterized by the new allele show photoperiod-related phenotypes likely to be adaptive in seasonal environments. ls-tim may be spreading from its point of origin in Italy by directional selection, but there are alternative explanations for its observed clinal geographical distribution, including balancing selection and demography. From population analyses of ls-tim frequencies collected on the eastern side of the Iberian Peninsula, we show that ls-tim frequencies are inverted compared with those in Italy. This pattern is consistent with a scenario of directional selection rather than latitude-associated balancing selection. Neutrality tests further reveal the signature of directional selection at the ls-tim site, which is reduced a few kb pairs either side of ls-tim. A reanalysis of allele frequencies from a large number of microsatellite loci do not demonstrate any frequent ls-tim-like spatial patterns, so a general demographic effect or population expansion from southeastern Italy cannot readily explain current ls-tim frequencies. Finally, a revised estimate of the age of ls-tim allele using linkage disequilibrium and coalescent-based approaches reveals that it may be only 300 to 3000 years old, perhaps explaining why it has not yet gone to fixation. ls-tim thus provides a rare temporal snapshot of a new allele that has come under selection before it reaches equilibrium.

Memory for Lectures: How Lecture Format Impacts the Learning Experience.

Directory of Open Access Journals (Sweden)

Trish L Varao-Sousa

Full Text Available The present study investigated what impact the presentation style of a classroom lecture has on memory, mind wandering, and the subjective factors of interest and motivation. We examined if having a professor lecturing live versus on video alters the learning experience of the students in the classroom. During the lectures, students were asked to report mind wandering and later complete a memory test. The lecture format was manipulated such that all the students received two lectures, one live and one a pre-recorded video. Results indicate that lecture format affected memory performance but not mind wandering, with enhanced memory in the live lectures. Additionally, students reported greater interest and motivation in the live lectures. Given that a single change to the classroom environment, professor presence, impacted memory performance, as well as motivation and interest, the present results have several key implications for technology-based integrations into higher education classrooms.

Lectures for CERN pensioners

CERN Multimedia

GS Department

2009-01-01

The Medical Service and the CERN and ESO Pensioners Association invite CERN pensioners to a series of presentations given by professors and specialists at the University Teaching Hospitals and the Faculty of Medicine at the University of Geneva on the subject of: PROMOTION OF OPTIMUM BRAIN AGEING The final series of presentations will be held in CERN’s Main Auditorium (Building 500) on: Wednesday, 25 February 2009, from 2:30 p.m. to 4:30 p.m. What is cerebral reserve ? Historique et importance de la notion de «réserve cérébrale» Prof. Ezio GIACOBINI Intervention de la réserve cérébrale sur les troubles de la cognition Prof. Jean-Pierre MICHEL Comment est-il possible d’évaluer la réserve cérébrale ? Prof. Gabriel GOLD Projet de recherche «Optimum Brain Ageing» -\tAspects méthodologiques - Dr François HERRMANN -\tAspects pratiques - Dr Dina ZEKRY The presentations will be given in French with overheads in English and will be followed by a wide-rangi...

Platinum Jubilee Lectures

Indian Academy of Sciences (India)

Indian Institute of Technology Madras, Chennai, 25 August 2009 ... in association with Bangalore Association for Science Education, 31 March 2009. [PJL10] How palaeoclimate studies can improve global warming forecasts. Prof. George ...

PROF-DD, Generator of Multigroup Cross-Sections Library DDX for MORSE-DD, ANISN-DD, DOT-DD

International Nuclear Information System (INIS)

Mori, Takamasa; Nakagawa, Masayuki; Ishiguro, Yukio

2002-01-01

1 - Description of program or function: The code system PROF-DD generates a multi-group double-differential cross section library DDX from evaluated data in ENDF/B-IV or ENDF/B-V format. The system consists of the following five modules: PROF-DDX is the main module of the system. It calculates the multigroup DDX and stores them on a master PDS file. MCFILEF generates a control file for PROF-DDX, which contains energy group and angle bin structures. SPINPTF prepares an input data file for PROF-DDX by combining the control file with other input data. DDXLIBMK edits a DDX library from the master PDS file for transport calculations. RESENDD performs resonance cross section and Doppler broadening calculations. 2 - Restrictions on the complexity of the problem: The numbers of energy groups and angle bins are less than 150 and 40, respectively

Earth-Mars Telecommunications and Information Management System (TIMS): Antenna Visibility Determination, Network Simulation, and Management Models

Science.gov (United States)

Odubiyi, Jide; Kocur, David; Pino, Nino; Chu, Don

1996-01-01

This report presents the results of our research on Earth-Mars Telecommunications and Information Management System (TIMS) network modeling and unattended network operations. The primary focus of our research is to investigate the feasibility of the TIMS architecture, which links the Earth-based Mars Operations Control Center, Science Data Processing Facility, Mars Network Management Center, and the Deep Space Network of antennae to the relay satellites and other communication network elements based in the Mars region. The investigation was enhanced by developing Build 3 of the TIMS network modeling and simulation model. The results of several 'what-if' scenarios are reported along with reports on upgraded antenna visibility determination software and unattended network management prototype.

Blocking Tim-3 or/and PD-1 reverses dysfunction of tumor-infiltrating lymphocytes in HBV-related hepatocellular carcinoma.

Science.gov (United States)

Liu, Furong; Zeng, Gucheng; Zhou, Shaotang; He, Xiaoshun; Sun, Nianfeng; Zhu, Xiaofeng; Hu, Anbin

2018-03-22

The immunosuppression of tumor-infiltrating lymphocytes (TILs) is associated with rapid progression of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). T cell Ig- and mucin-domain-containing molecule-3 (Tim-3) and programmed cell death 1 (PD-1) are important inhibitory molecules expressed on the surface of T cells, but their roles in the function of TILs in HBV-HCC are poorly understood. We aimed to study the roles of these two markers in HBV-HCC. Ninety patients with pathologically confirmed HBV-associated HCC were enrolled in our study. Blood samples, paired fresh tumor tissues and adjacent tissues were collected, and isolating peripheral blood mononuclear cells, TILs and adjacent-infiltrating lymphocytes were isolated from these samples. The patients were followed-up to allow survival analysis. Tim-3 or/and PD-1 was up-regulated expressed on CD4 + and CD8 + TILs in HBV-HCC patients and a higher proportion of TILs expressed PD-1 alone. Tim-3 + and PD-1 + TILs greatly decreased secretion of IFN-γ and TNF-α. Expression of Tim-3 and PD-1 on TILs negatively correlated with disease-free survival of HCC patients. Direct blockade of Tim-3 and PD-1 in vitro significantly enhanced TILs proliferation and secretion of IFN-γ and TNF-α. Expression of Tim-3 and/or PD-1 on TILs impairs their function and correlates negatively with disease-free survival in HBV-HCC. Direct blockade of Tim-3 and PD-1 restores anti-tumor effects of TILs, which suggests a potential target for novel immunotherapy in HBV-HCC. Copyright © 2018 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Live lecture versus video-recorded lecture: are students voting with their feet?

Science.gov (United States)

Cardall, Scott; Krupat, Edward; Ulrich, Michael

2008-12-01

In light of educators' concerns that lecture attendance in medical school has declined, the authors sought to assess students' perceptions, evaluations, and motivations concerning live lectures compared with accelerated, video-recorded lectures viewed online. The authors performed a cross-sectional survey study of all first- and second-year students at Harvard Medical School. Respondents answered questions regarding their lecture attendance; use of class and personal time; use of accelerated, video-recorded lectures; and reasons for viewing video-recorded and live lectures. Other questions asked students to compare how well live and video-recorded lectures satisfied learning goals. Of the 353 students who received questionnaires, 204 (58%) returned responses. Collectively, students indicated watching 57.2% of lectures live, 29.4% recorded, and 3.8% using both methods. All students have watched recorded lectures, and most (88.5%) have used video-accelerating technologies. When using accelerated, video-recorded lecture as opposed to attending lecture, students felt they were more likely to increase their speed of knowledge acquisition (79.3% of students), look up additional information (67.7%), stay focused (64.8%), and learn more (63.7%). Live attendance remains the predominant method for viewing lectures. However, students find accelerated, video-recorded lectures equally or more valuable. Although educators may be uncomfortable with the fundamental change in the learning process represented by video-recorded lecture use, students' responses indicate that their decisions to attend lectures or view recorded lectures are motivated primarily by a desire to satisfy their professional goals. A challenge remains for educators to incorporate technologies students find useful while creating an interactive learning culture.

Site Wellenberg: ENSI's view on the expert report by Prof. Jon Mosar

International Nuclear Information System (INIS)

2011-08-01

A public consultation on Stage 1 of the Sectoral Plan 'Deep Geological Disposal' (SGT) aiming at identifying the best site location, took place in Switzerland. In the framework of the elaboration of a report on this consultation by the Swiss Federal Office of Energy (BFE), the Swiss Federal Nuclear Safety Inspectorate (ENSI) had to discuss the safety relevant objections. In addition to its own memorandum, the government of the Canton of Nidwalden entered the expert report 'Assessment of the tectonics of the site region Wellenberg (Ct. NW/OW) with regard to a deep repository for low- and intermediate-level radioactive wastes' by Prof. Jon Mosar (University of Fribourg/CH). In his expert report, Mosar concludes that, globally considered, this site should be declared as inappropriate. In the present report, ENSI gives a detailed evaluation of this expert report. In its evaluation, ENSI was supported by the Swiss Seismological Service (SED) that checked Prof. Mosar's statements about the seismicity. SED came up to the conclusion that Prof. Mosar's statements are basically correct. But the allocation of the seismic events to single structural components, as Prof. Mosar did, is not possible because of the large inaccuracies in the localization of the hypocentres. From the SED statements it further comes out that the data set used earlier by the National Cooperative for the Disposal of Radioactive Waste (NAGRA) is in agreement with the seismic events that have been observed meanwhile. A series of smaller seismic events during the year 2005 in conjunction with strong rain falls in the region, constitutes, however, a notable exception. The strength of such a seismic activity is limited. The expert report by Prof. Mosar is restricted to the aspects of tectonics and seismicity. For a complete evaluation of the aptitude of the site region, all 13 safety technical criteria required by the Sectoral Plan SGT should be evaluated and that was not done in the present expert report

A quantitative analysis of TIMS data obtained on the Learjet 23 at various altitudes

Science.gov (United States)

Jaggi, S.

1992-01-01

A series of Thermal Infrared Multispectral Scanner (TIMS) data acquisition flights were conducted on the NASA Learjet 23 at different altitudes over a test site. The objective was to monitor the performance of the TIMS (its estimation of the brightness temperatures of the ground scene) with increasing altitude. The results do not show any significant correlation between the brightness temperatures and the altitude. The analysis indicates that the estimation of the temperatures is a function of the accuracy of the atmospheric correction used for each altitude.

Analysis of Eocene depositional environments - Preliminary TM and TIMS results, Wind River Basin, Wyoming

Science.gov (United States)

Stucky, Richard K.; Krishtalka, Leonard; Redline, Andrew D.; Lang, Harold R.

1987-01-01

Both Landsat TM and aircraft Thermal IR Multispectral Scanner (TIMS) data have been used to map the lithofacies of the Wind River Basin's Eocene physical and biological environments. Preliminary analyses of these data have furnished maps of a fault contact boundary and a complex network of fluvial ribbon channel sandstones. The synoptic view thereby emerging for Eocene fluvial facies clarifies the relationships of ribbon channel sandstones to fossil-bearing overbank/floodplain facies and certain peleosols. The utility of TM and TIMS data is thereby demonstrated.

Onsite: A Residency with Tim Rollins/KOS. A Photo Essay.

Science.gov (United States)

Placky, Robert

2000-01-01

Presents a photo essay that visually narrates the workshop that took place in State College, Pennsylvania, from October 19-24, 1998 bringing together middle and high school students with Tim Rollins, who is a conceptual artist and educator, and Kids of Survival (KOS). (CMK)

α-Lactose Improves the Survival of Septic Mice by Blockade of TIM-3 Signaling to Prevent NKT Cell Apoptosis and Attenuate Cytokine Storm.

Science.gov (United States)

Yao, Yao; Deng, Hai; Li, Pingfei; Zhang, Jian; Zhang, Junbo; Wang, Deping; Li, Songbo; Luo, Yixing; Wei, Zhengping; Bi, Guoyu; Yang, Xiang-Ping; Tang, Zhao-Hui

2017-03-01

Sepsis is the leading cause of death among critically ill patients and natural killer T (NKT) cell activation is essential to induce inflammatory cytokine cascade in sepsis. However, little is known about what regulates the NKT cell function during sepsis. Herein, we showed that T-cell immunoglobulin and mucin domain 3 (Tim-3) expression in NKT cells is elevated in experimental mice during sepsis. Tim-3 expression was positively correlated with NKT cell activation and apoptosis. In sepsis, interleukin (IL)-12 secreted by dendritic cell exposure to lipopolysaccharide increased the expression of Tim-3 in NKT cells. Administration of α-lactose to block Tim-3 signaling pathway significantly improved the survival of septic mice, concomitant with reduced IL-12 production by dendritic cells, reduced Tim-3 expression, prevented NKT cell apoptosis, and attenuated production of inflammatory cytokines. Collectively, Tim-3 signaling in NKT cells plays a critical role in the immunopathogenesis of sepsis. Thus, α-lactose could be a promising immunomodulatory agent in the treatment of sepsis.

Five Lectures on Photosynthesis

International Nuclear Information System (INIS)

Broda, E.

1979-01-01

These five lectures were held by E. Broda during the International Symposium on Alternative Energies, in September 1979. Lecture 1 – The Great Physicists and Photosynthesis; Lecture 2 – The Influence of Photosynthesis on the Biosphere. Past, Present and Future; Lecture 3 – The Origin of Photosynthesis; Lecture 4 – The Evolution from Photosynthetic Bacteria to Plants; Lecture 5 – Respiration and Photorespiration. (nowak)

CANDU lectures

International Nuclear Information System (INIS)

Rouben, B.

1984-06-01

This document is a compilation of notes prepared for two lectures given by the author in the winter of 1983 at the Institut de Genie Nucleaire, Ecole Polytechnique, Montreal. The first lecture gives a physical description of the CANDU reactor core: the nuclear lattice, the reactivity mechanisms, their functions and properties. This lecture also covers various aspects of reactor core physics and describes different calculational methods available. The second lecture studies the numerous facets of fuel management in CANDU reactors. The important variables in fuel management, and the rules guiding the refuelling strategy, are presented and illustrated by means of results obtained for the CANDU 600

Smart Mirrors for Photorefractive Control of Light with Tim Bunning, RX - Agile Filters Application

Science.gov (United States)

2016-11-08

AFRL-AFOSR-UK-TR-2017-0008 Smart Mirrors for photorefractive control of light with Tim Bunning, RX-- Agile filters application Luciano De Sio...DATE (DD-MM-YYYY)      10-02-2017 2. REPORT TYPE Final 3. DATES COVERED (From - To) 01 Feb 2014 to 31 Jan 2016 4. TITLE AND SUBTITLE Smart Mirrors for...photorefractive control of light with Tim Bunning, RX-- Agile filters application 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA9550-14-1-0050 5c.  PROGRAM

Society News: Monica Grady awarded CBE; Grubb Parsons Lecture 2012; Join the RAS; Astronomy on radio for kids; New Fellows; Peter D Hingley

Science.gov (United States)

2012-08-01

RAS Fellow Prof. Monica Grady has been made a Commander of the Most Excellent Order of the British Empire (CBE), in recognition of her services to space science. The RAS sponsors the annual Grubb Parsons Lecture, which this year took place on 6 June at the University of Durham. If you are a professional astronomer, geophysicist, or similar, a student studying these disciplines, or simply someone with a serious interest in them, we urge you to apply for membership of the RAS. Outreach is an important activity for the RAS. We recently supported an astronomy series called Deep Space High on the digital radio channel Fun Kids.

Suppression of TIM-1 predicates clinical efficacy of sublingual immunotherapy for allergic rhinitis in children.

Science.gov (United States)

Lin, Zhibin; Zhou, Lifeng; Luo, Xi; Xia, Wentong; Chen, Dehua; Xu, Rui; Wang, Jie; Luo, Renzhong; Xu, Geng; Li, Huabin

2013-08-01

To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) with house-dust mite (HDM) extract and to examine the change of biomarkers (TIM-1, IL-5 and IL-10) after 6-month SLIT in children with allergic rhinitis (AR). One hundred and sixteen HDM-sensitized children with persistent AR were enrolled to assess the clinical efficacy of SLIT by determining the individual nasal symptom score (INSS) and total nasal symptom scores (TNSS) after 6-month SLIT. Moreover, the mRNA expression of TIM-1, IL-5 and IL-10 in peripheral blood mononuclear cells (PBMCs) was examined in 16 well-controlled and 12 uncontrolled AR patients using quantitative reverse transcription polymerase chain reaction (qRT-PCR). After 6-month SLIT, both TNSS and INSS scores were significantly decreased compared with the baseline value (p < 0.01). The rates for well-controlled, partly controlled and uncontrolled children were 43.1%, 32.8% and 24.1%, respectively. Accordingly, the mRNA levels of TIM-1 and IL-5 decreased significantly and IL-10 mRNA level increased significantly compared with the baseline value in well-controlled children (p < 0.05). Our findings suggest SLIT with HDM extract is effective and safe for AR children and TIM-1 may be considered as an indicator for evaluating the clinical efficacy of SLIT. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

The Web-Lecture - a viable alternative to the traditional lecture format?

Science.gov (United States)

Meibom, S.

2004-12-01

Educational research shows that students learn best in an environment with emphasis on teamwork, problem-solving, and hands-on experience. Still professors spend the majority of their time with students in the traditional lecture-hall setting where the combination of large classes and limited time prevents sufficient student-teacher interaction to foster an active learning environment. Can modern computer technology be used to provide "lecture-type" information to students via the World Wide Web? If so, will that help professors make better and/or different use of their scheduled time with the students? Answering these questions was the main motivation for the Extra-Solar Planet Project. The Extra-Solar Planet Project was designed to test the effectiveness of a lecture available to the student on the World Wide Web (Web-Lecture) and to engage the students in an active learning environment were their use the information presented in the Web-Lecture. The topic of the Web-Lecture was detection of extra-solar planets and the project was implemented into an introductory astronomy course at University of Wisconsin Madison in the spring of 2004. The Web-Lecture was designed to give an interactive presentation of synchronized video, audio and lecture notes. It was created using the eTEACH software developed at the University of Wisconsin Madison School of Engineering. In my talk, I will describe the project, show excerpts of the Web-Lecture, and present assessments of student learning and results of student evaluations of the web-lecture format.

HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

Directory of Open Access Journals (Sweden)

Lishomwa C Ndhlovu

2011-04-01

Full Text Available The T cell immunoglobulin mucin 3 (Tim-3 receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted" and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurological complex and its classic neurological presentation called HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis, we investigated the expression of the Tim-3 receptor on CD8(+ T cells from a cohort of HTLV-1 seropositive asymptomatic and symptomatic patients. Patients diagnosed with HAM/TSP down-regulated Tim-3 expression on both CD8(+ and CD4(+ T cells compared to asymptomatic patients and HTLV-1 seronegative controls. HTLV-1 Tax-specific, HLA-A*02 restricted CD8(+ T cells among HAM/TSP individuals expressed markedly lower levels of Tim-3. We observed Tax expressing cells in both Tim-3(+ and Tim-3(- fractions. Taken together, these data indicate that there is a systematic downregulation of Tim-3 levels on T cells in HTLV-1 infection, sustaining a profoundly highly active population of potentially pathogenic T cells that may allow for the development of HTLV-1 complications.

NSA Profs. Barma and Piombo Publish Jointly in International Peacekeeping

OpenAIRE

2016-01-01

National Security Affairs (NSA) News Two NSA faculty, Profs. Naazneen Barma and Jessica Piombo have authored an article with Naomi Levy of Santa Clara University, titled “Disentangling Aid Dynamics in Statebuilding and Peacebuildin: A Causal Framework.”

Vocal intensity in lecturers: Results of measurements conducted during lecture sessions

Directory of Open Access Journals (Sweden)

Witold Mikulski

2013-12-01

Full Text Available Background: Occupational voice users (inter alia: lecturers speak with different levels of vocal intensity. Speakers adjust this intensity knowingly (e.g. to underline the importance of fragments of the speech or unknowingly. The unknown adjustment of voice intensity occurs e.g. in the presence of high acoustic background noise (so-called Lombard effect, but it also results from many other factors: hearing loss, construction of the vocal tract, habits and others. The aim of the article is to confirm the thesis that in similar conditions of acoustic properties of the room different lecturers speak with different levels of vocal intensity. Materials and Methods: The study was conducted in a group of 10 lecturers in the same conference room. A-weighted sound pressure level determined at 1 m from the lecturer's mouth was adopted as a parameter defining the intensity of the lecturer's voice. The levels of all lecturers' voice intensity were compared and evaluated according to the criteria defined in EN ISO 9921. Results: Nine in ten lecturers were speaking with normal voice intensity (60-65 dB and only one full-time university lecturer was speaking with raised voice (66-71 dB. Conclusions: It was found that in the room of the same acoustic conditions the lecturers spoke with different intensities of voice. Some lecturers occasionally, and one all the time spoke with the voice intensity specified by PN-EN ISO 9921 as a raised voice. The results of the preliminary study warrant further studies in a larger group of teachers. Med Pr 2013;64(6:797–804

ACADEMIC TRAINING LECTURE

CERN Multimedia

Academic Training; Tel 73127

2001-01-01

28, 29, 30, 31 May and 1 June REGULAR LECTURE PROGRAMME From 11:00 hrs - Main Auditorium bldg. 500 Quantum computing and Quantum cryptography T. Hey / University of Southampton, GB, and D. Ross / CERN-TH This course will give both an overview and a detailed introduction to quantum computing and quantum cryptography. The first lecture will survey the field, starting from its origins in Feyman's lecture in 1981. The next three lectures will explain in detail the relevance of Bell states and the workings of Grover's Quantum Search and Shor's quantum factorization algorithms. In addition, an explanation of quantum teleportation will be given. The last lecture will survey the recent progress towards realizing working quantum computers and quantum cryptographic systems.

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway.

LENUS (Irish Health Repository)

Cao, Wei

2011-06-01

Emerging experimental data suggest an important role for the T-cell immunoglobulin mucin 1 (Tim-1):Tim-4 pathway in autoimmune and alloimmune responses in vivo. Using a Tim-4 ectodomain human IgG Fc fusion protein we studied the role of Tim-4 in T-cell activation, signalling and differentiation responses in vitro. We demonstrate that Tim-4Fc can inhibit naive and pre-activated T-cell activation, proliferation and cytokine secretion via a Tim-1-independent pathway. Tim-4 contains immunoglobulin variable (IgV) and mucin domains; to identify which domain accounts for the inhibitory effect novel Tim-4 fusion proteins containing either the IgV or mucin domain were generated. We demonstrate that both IgV and mucin domains are required for the inhibitory effects and that they are mediated at least in part by inhibition of extracellular signal-regulated kinase pathway activity. Given the emerging interest in the role of the Tim family in T helper type 17 (Th17) cells, which play an important role in autoimmune disease and transplantation tolerance, our data show that Tim-4Fc can prevent polarization of CD4(+) T cells to the Th17 phenotype. Collectively, our results highlight an inhibitory role for Tim-4Fc in vitro, which we propose is mediated by a receptor other than Tim-1. In addition, this study provides new insights into the role of Tim-4Fc in regulating Th17 immune responses and may open a new avenue for autoimmune therapy.

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway

Science.gov (United States)

Cao, Wei; Ryan, Michelle; Buckley, Deirdre; O'Connor, Rosemary; Clarkson, Michael R

2011-01-01

Emerging experimental data suggest an important role for the T-cell immunoglobulin mucin 1 (Tim-1):Tim-4 pathway in autoimmune and alloimmune responses in vivo. Using a Tim-4 ectodomain human IgG Fc fusion protein we studied the role of Tim-4 in T-cell activation, signalling and differentiation responses in vitro. We demonstrate that Tim-4Fc can inhibit naive and pre-activated T-cell activation, proliferation and cytokine secretion via a Tim-1-independent pathway. Tim-4 contains immunoglobulin variable (IgV) and mucin domains; to identify which domain accounts for the inhibitory effect novel Tim-4 fusion proteins containing either the IgV or mucin domain were generated. We demonstrate that both IgV and mucin domains are required for the inhibitory effects and that they are mediated at least in part by inhibition of extracellular signal-regulated kinase pathway activity. Given the emerging interest in the role of the Tim family in T helper type 17 (Th17) cells, which play an important role in autoimmune disease and transplantation tolerance, our data show that Tim-4Fc can prevent polarization of CD4+ T cells to the Th17 phenotype. Collectively, our results highlight an inhibitory role for Tim-4Fc in vitro, which we propose is mediated by a receptor other than Tim-1. In addition, this study provides new insights into the role of Tim-4Fc in regulating Th17 immune responses and may open a new avenue for autoimmune therapy. PMID:21463297

Wyle Prof H G Viljoen | Geyser | HTS Teologiese Studies ...

African Journals Online (AJOL)

HTS Teologiese Studies / Theological Studies. Journal Home · ABOUT · Advanced Search · Current Issue · Archives · Journal Home > Vol 9, No 2 (1953) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Wyle Prof H G Viljoen. A S Geyser. Abstract. No Abstract ...

Servicing the first web server - Tim Berners-Lee's NeXT

CERN Multimedia

unknown, Association aBCM

2009-01-01

In August 2009 a team from the Association aBCM in Lausanne came to CERN to give the world's first web server a health check under the watchful eye of web pioneer Robert Cailliau. They took an image of the hard drive at this time, copies of which were given to Robert Cailliau and Tim Berners-Lee.

The TimBel synchronization board for time resolved experiments at synchrotron SOLEIL

International Nuclear Information System (INIS)

Ricaud, J.P.; Betinelli-Deck, P.; Bisou, J.; Elattaoui, X.; Laulhe, C.; Monteiro, P.; Nadolski, L.S.; Renaud, G.; Ravy, S.; Silly, M.; Sirotti, F.

2012-01-01

Time resolved experiments are one of the major services that synchrotrons can provide to scientists. The short, high frequency and regular flashes of synchrotron light are a fantastic tool to study the evolution of phenomena over time. To carry out time resolved experiments, beamlines need to synchronize their devices with these flashes of light with a jitter shorter than the pulse duration. For that purpose, Synchrotron SOLEIL has developed the TimBeL (Timing Beamlines) board fully interfaced to TANGO framework. The TimBeL system is a compact PCI board. It is made of a mother with one daughter board. All functions are performed inside a FPGA (Field Programmable Gate Array) implemented on the mother board. A PLX Technology chip is used to communicate with the compact PCI crate. To enable experiments to remain always synchronous with the same bunch of electrons, the storage ring clock (CLK-SR) and the radio frequency clock (CLK-RF) are provided by the machine to beamlines. These clocks are used inside the FPGA as main clocks for state machines. Because the jitter is too large on the FPGA outputs, a daughter board with a jitter cleaner has been added to the system. This board also provides delay lines for compensating time offsets by 10 ps steps. This paper presents the main features required by time resolved experiments and how we achieved our goals with the TimBeL board

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry

OpenAIRE

Rhein, Bethany A.; Brouillette, Rachel B.; Schaack, Grace A.; Chiorini, John A.; Maury, Wendy

2016-01-01

Phosphatidylserine (PtdSer) receptors that are responsible for the clearance of dying cells have recently been found to mediate enveloped virus entry. Ebola virus (EBOV), a member of the Filoviridae family of viruses, utilizes PtdSer receptors for entry into target cells. The PtdSer receptors human and murine T-cell immunoglobulin mucin (TIM) domain proteins TIM-1 and TIM-4 mediate filovirus entry by binding to PtdSer on the virion surface via a conserved PtdSer binding pocket within the amin...

Report on visit from Prof. Kim Lutzen: Friday, 6 November 1998, Korolinska Institute (dept of nursing Stockholm, Sweden

Directory of Open Access Journals (Sweden)

Kim Lutzen

1999-10-01

Full Text Available Prof. Kim Lutzen contacted the Department of Advanced Nursing Sciences, Unisa, via the Department's Web Page. Prof. Lutzen is the Chair of the Department of Nursing, which offers undergraduate, master and doctoral programmes. This Department of Nursing is situated within the Karolinska Institute, which comprises 29 Departments of Health Sciences, including a number of Medical Departments, Dentistry, Occupational Therapy, Physiotherapy, and Nursing. Prof. Lutzen emphasised that there is no Swedish phrase similar to "nursing science", consequently this t e n seems to be somewhat unfamiliar to the Swedish nurses. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

THE MAN HAD LINGUISTICS LIKED: PROF. DR. DOĞAN AKSAN DİL BİLİMİNİ SEVDİREN ADAM: PROF. DR. DOĞAN AKSAN (1929-2010

Directory of Open Access Journals (Sweden)

Ahmet Turan SİNAN

2010-10-01

Full Text Available Who is the linguistics studies’ the one of innovators in Turkey, Prof. Dr. Doğan Aksan is very important scientist who fall in love with Turkish, reweal the richness and power of expression of our mother tangue. He displays a lot of European turcologits’ delussions as A. von Gabain, R. Giraud, J. Kramsky for Turkish with his studies. Aksan, who writes a lot of studies for shabbiness, semantic features, expression, flexibility of Turkish, Turkish education, takes place between founders of linguistic in Turkey. He displays the big love to Turkish by serving to Turkish in the light of the methods and techniques of universal linguistic. Prof. Dr. Doğan Aksan will be remember always as a very important scientist and the man had linguistics liked. Türkiye’deki dil bilim çalışmalarının öncülerinden olan Prof. Dr. Doğan Aksan; Türkçeye gönül vermiş, anlam bilim çalışmaları ile ana dilimizin zenginliğini ve anlatım gücünü gözler önüne seren çok önemli bir bilim adamıdır. Bu çalışmaları ile A. von Gabain, R. Giraud, J. Kramsky gibi birçok Avrupalı Türkologun Türkçeye yönelik yanılgılarını da ortaya koymuştur. Türkçenin eskiliğine, anlamsal özelliklerine, anlatım gücü ve esnekliğine, Türkçe öğretimine yönelik birçok esere imza atan Aksan, Türkiye’de dil bilimin kurucuları arasında yer alır. Türkçeye olan büyük sevgisini evrensel dil bilimin yöntem ve teknikleri ışığında hizmet ederek göstermiştir. Prof. Dr. Doğan Aksan, çok önemli bir bilim adamı ve her şeyden önce dil bilimi sevdiren kişi olarak daima hatırlanacaktır.

U-series dating using thermal ionisation mass spectrometry (TIMS)

International Nuclear Information System (INIS)

McCulloch, M.T.

1999-01-01

U-series dating is based on the decay of the two long-lived isotopes 238 U(τ 1/2 =4.47 x 10 9 years) and 235 U (τ 1/2 0.7 x 10 9 years). 238 U and its intermediate daughter isotopes 234 U (τ 1/2 = 245.4 ka) and 230 Th (τ 1/2 = 75.4 ka) have been the main focus of recently developed mass spectrometric techniques (Edwards et al., 1987) while the other less frequently used decay chain is based on the decay 235 U to 231 Pa (τ 1/2 = 32.8 ka). Both the 238 U and 235 U decay chains terminate at the stable isotopes 206 Pb and 207 Pb respectively. Thermal ionization mass spectrometry (TIMS) has a number of inherent advantages, mainly the ability to measure isotopic ratios at high precision on relatively small samples. In spite of these now obvious advantages, it is only since the mid-1980's when Chen et al., (1986) made the first precise measurements of 234 U and 232 Th in seawater followed by Edwards et al., (1987) who made combined 234 U- 230 Th measurements, was the full potential of mass spectrometric methods first realised. Several examples are given to illustrate various aspects of TIMS U-series

Insights into the fold organization of TIM barrel from interaction energy based structure networks.

Science.gov (United States)

Vijayabaskar, M S; Vishveshwara, Saraswathi

2012-01-01

There are many well-known examples of proteins with low sequence similarity, adopting the same structural fold. This aspect of sequence-structure relationship has been extensively studied both experimentally and theoretically, however with limited success. Most of the studies consider remote homology or "sequence conservation" as the basis for their understanding. Recently "interaction energy" based network formalism (Protein Energy Networks (PENs)) was developed to understand the determinants of protein structures. In this paper we have used these PENs to investigate the common non-covalent interactions and their collective features which stabilize the TIM barrel fold. We have also developed a method of aligning PENs in order to understand the spatial conservation of interactions in the fold. We have identified key common interactions responsible for the conservation of the TIM fold, despite high sequence dissimilarity. For instance, the central beta barrel of the TIM fold is stabilized by long-range high energy electrostatic interactions and low-energy contiguous vdW interactions in certain families. The other interfaces like the helix-sheet or the helix-helix seem to be devoid of any high energy conserved interactions. Conserved interactions in the loop regions around the catalytic site of the TIM fold have also been identified, pointing out their significance in both structural and functional evolution. Based on these investigations, we have developed a novel network based phylogenetic analysis for remote homologues, which can perform better than sequence based phylogeny. Such an analysis is more meaningful from both structural and functional evolutionary perspective. We believe that the information obtained through the "interaction conservation" viewpoint and the subsequently developed method of structure network alignment, can shed new light in the fields of fold organization and de novo computational protein design.

Prof. T. S. Sadasivan | History | About IASc | Indian Academy of ...

Indian Academy of Sciences (India)

Career: Univ. of Lucknow, Dept. of Botany: Demonstrator 40-41; Fruit and Vegetable Preservation Lab., Lyaupur: Microbiologist 41-44; Univ. of Madras, Centre for Ad-vanced Studies in Botany: Director/Prof. 44-73; CSIR, Plant-based Lab.: Consultant 73-76; Birbal Sahni Professor, Lucknow 77-80; Vidyashram, Kodaikanal: ...

Consumerism, Activism, Intrinsic Motivation, and Balance: An Interview with Tim Kasser

Science.gov (United States)

Keeley, Jared

2010-01-01

A year after receiving his PhD in psychology from the University of Rochester, Tim Kasser accepted a position at Knox College, in Galesburg, Illinois, where he is currently professor of psychology. He regularly teaches psychology classes on personality, clinical and abnormal psychology, dreaming, and research methods, as well as an…

Activation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant.

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Kerry L Hilligan

Full Text Available Macrophage and dendritic cell (DC populations residing in the intestinal lamina propria (LP are highly heterogeneous and have disparate yet collaborative roles in the promotion of adaptive immune responses towards intestinal antigen. Under steady-state conditions, macrophages are efficient at acquiring antigen but are non-migratory. In comparison, intestinal DC are inefficient at antigen uptake but migrate to the mesenteric lymph nodes (mLN where they present antigen to T cells. Whether such distinction in the roles of DC and macrophages in the uptake and transport of antigen is maintained under immunostimulatory conditions is less clear. Here we show that the scavenger and phosphatidylserine receptor T cell Immunoglobulin and Mucin (TIM-4 is expressed by the majority of LP macrophages at steady-state, whereas DC are TIM-4 negative. Oral treatment with the mucosal adjuvant cholera toxin (CT induces expression of TIM-4 on a proportion of CD103+ CD11b+ DC in the LP. TIM-4+ DC selectively express high levels of co-stimulatory molecules after CT treatment and are detected in the mLN a short time after appearing in the LP. Importantly, intestinal macrophages and DC expressing TIM-4 are more efficient than their TIM-4 negative counterparts at taking up apoptotic cells and soluble antigen ex vivo. Taken together, our results show that CT induces phenotypic changes to migratory intestinal DC that may impact their ability to take up local antigens and in turn promote the priming of mucosal immunity.

TIM Series: Theory, Evidence and the Pragmatic Manager

Directory of Open Access Journals (Sweden)

Steven Muegge

2008-08-01

Full Text Available On July 2, 2008, Steven Muegge from Carleton University delivered a presentation entitled "Theory, Evidence and the Pragmatic Manager". This section provides the key messages from the lecture. The scope of this lecture spanned several topics, including management decision making, forecasting and its limitations, the psychology of expertise, and the management of innovation.

DIVERSITAS TIM MANAJEMEN PUNCAK, KEKOMPREHENSIFAN PENGAMBILAN KEPUTUSAN, INTEGRASI SOSIAL DAN KINERJA PERUSAHAAN: STUDI PADA BANK PERKREDITAN RAKYAT

Directory of Open Access Journals (Sweden)

Arief Prima Johan

2014-07-01

Full Text Available AbstractAlthough research on diversity management team had been widely conducted, previous research defined diversity in many different ways and many studies focused their research on top management team of big companies and big industries. This study examined the influence of several type of diversity of top management team on decision-making comprehensiveness and social integration, and tests these last two variables on performance. Using data Rural Banks (banking industry, the results showed that several variables of diversity of top management team affect decision-making comprehensiveness and social integration. The study also confirmed that the company's performance is affected by decision-making comprehensiveness and social integration.Keywords:Team Management, Diversity, Decision-Making Comprehensiveness, Social Integration, Performance.AbstrakMeskipun penelitian mengenai diversitas tim manajemen sudah banyak dilakukan, tetapi penelitian yang lalu mendefinisikan diversitas dengan cara yang berbeda-beda dan banyak berfokus pada tim manajemen puncak perusahaan besar dan industri besar. Penelitian ini menguji pengaruh variable-variabel diversitas tim manajemen puncak perusahaan terhadap kekomprehensifan pengambilan keputusan dan integrasi sosial, serta menguji dua variable terakhir ini pada kinerja. Dengan menggunakan data Bank Perkreditan Rakyat (industri perbankan, hasil penelitian memperlihatkan bahwa beberapa variable diversitas manajemen puncak mempengaruhi kekomprehensifan pengambilan keputusan dan integrasi sosial.Penelitian juga mengkonfirmasi bahwa kinerja perusahaan dipengaruhi oleh kekomprehensifan pengambilan keputusan dan integrasi sosial.Kata Kunci:Tim Manajemen Puncak, Diversitas, Kekomprehensifan, Pengambilan Keputusan, Integrasi Sosial, Kinerja Perusahaan.

Space Solar Power Exploratory Research and Technology (SERT) Technical Interchange Meeting 2 (SERT TIM 2)

Science.gov (United States)

Howell, Joe; Sanders, Clark W.

2000-01-01

The University of Alabama in Huntsville's (UAH) Propulsion Research Center hosted the Space Solar Power Exploratory Research & Technology (SERT) Technical Interchange Meeting TIM) 2 in Huntsville, Alabama December 7-10. 1999 with 126 people in attendance. The SERT program includes both competitively procured activities. which are being implemented through a portfolio of focused R&D investments--with the maximum leveraging of existing resources inside and outside NASA. and guided by these system studies. Axel Roth. Director of the Flight Projects Directorate NASA MSFC, welcomed the SERT TIM 2 participants and challenged them to develop the necessary technologies and demonstrations that will lead to Space Solar Power (SSP) International implementation. Joe Howell, NASA MSFC, reiterated the SERT TIM 2 objectives: 1) Refining and modeling systems approaches for the utilization of SSP concepts and technologies, ranging, from the near-term e.g. for space science, exploration and commercial space applications to the far-term (e. g. SSP for terrestrial markets), including systems concepts, technology, infrastructure (i.g., transportation), and economics. 2) Conducting technology research, development and demonstration activities to produce "proof- of-concept" validation of critical SSP elements for both the nearer and farther-term applications. 3) Initiating partnerships Nationality and Internationally that could be expanded, as appropriate, to pursue later SSP technology and applications (e.g., space science. colonization, etc.). Day one began with the NASA Centers presenting their SERT activities summary since SERT TIM 1 and wound up with a presentation by Masahiro Mori, NASDA titled "NASDA In-house Study for SSP". Demonstration for the Near-Term. Day two began with the SERT Systems Studies and Analysis reports resulting from NRA 8-23 followed by presentations of SERT Technology Demonstrations reports resulting from NRA 8-23. Day two closed with John Mankins presentation

Interactive lectures in engineering education

NARCIS (Netherlands)

van Dijk, L.A.; van den Berg, G.C.; van Keulen, H.

2001-01-01

This article discusses an alternative approach to lecturing: the interactive lecture. In the literature, interactive teaching is forwarded as a means to increase the effectiveness of lectures. Members of lecturing staff still seem, however, reluctant to incorporate interactive teaching in their

Infrared spectroscopy for geologic interpretation of TIMS data

Science.gov (United States)

Bartholomew, Mary Jane

1986-01-01

The Portable Field Emission Spectrometer (PFES) was designed to collect meaningful spectra in the field under climatic, thermal, and sky conditions that approximate those at the time of the overflight. The specifications and procedures of PFES are discussed. Laboratory reflectance measurements of rocks and minerals were examined for the purpose of interpreting Thermal Infrared Multispectral Scanner (TIMS) data. The capability is currently being developed to perform direct laboratory measurement of the normal spectral radiance of Earth surface materials at low temperatures (20 to 30 C) at the Jet Propulsion Laboratory.

Up-regulated expression of Tim-3/Gal-9 at maternal-fetal interface in pregnant woman with recurrent spontaneous abortion.

Science.gov (United States)

Li, Jing; Li, Fan-fan; Zuo, Wei; Zhou, Yuan; Hao, Hai-yan; Dang, Jing; Jiang, Min; He, Meng-zhou; Deng, Dong-rui

2014-08-01

The relationship between T cell immunoglobulin domain and mucin domain protein 3 (Tim-3)/Galectin (Gal)-9 pathway and recurrent spontaneous abortion (RSA) was studied. Thirty-one pregnant women with RSA and 27 normal early gravidas were investigated to detect the levels of Tim-3 and Gal-9 in villi and deciduas by Western blotting. Meanwhile, the concentration of interleukin (IL)-4 and IL-12 in peripheral blood plasma was determined by ELISA in 25 healthy fertile non-pregnant controls, the normal early gravidas and pregnant women with RSA mentioned above, respectively. It was found that the relative expression levels of Tim-3 and Gal-9 in villi and deciduas were significantly increased in pregnant women with RSA as compared with those in the normal early gravidas. The concentration of IL-4 in peripheral blood plasma of pregnant women with RSA was lower than that of the normal early gravidas (Ppregnant controls (Ppregnant women with RSA was significantly higher than that of the normal early gravidas (Ppregnant controls (P<0.05). It was suggested that the overexpression of Tim-3/Gal-9 pathway may be related to the pathogenesis of RSA.

Characteristics of the Institute of Technology 'Prof. Jorge A. Sabato'; Caracteristicas del Instituto de Tecnologia 'Prof. Jorga A. Sabato'

Energy Technology Data Exchange (ETDEWEB)

Galvele, Jose R [Comision Nacional de Energia Atomica, General San Martin (Argentina). Centro Atomico Constituyentes

2001-07-01

A historical survey is made of the educational and training activities in metallurgy and material sciences carried out by the CNEA since 1962, that were the origin of the 'Prof. Jorge A. Sabato' Institute. Today the Institute, created by the CNEA in association with the National University of General San Martin, is preparing Engineers in Material Sciences and Masters and Ph. D. in Material Sciences and Technology (Mention in Physics and Material). The curricula of the studies are described in detail. The Information Center annexed to the Institute is also described.

A short life history of Prof. Dr. F.P. Jonker

NARCIS (Netherlands)

Janssen, C.R.

1978-01-01

This year Prof. Dr. F.P. Jonker, Frits as he is known among his friends, will retire from the formal academic life at the State University of Utrecht: a long and busy life of 49 years, devoted to teaching, administration, and scientific research. Looking back on all these years, one realises the

Issues in Lecturing in a Second Language: Lecturer's Behaviour and Students' Perceptions

Science.gov (United States)

Miller, Lindsay

2007-01-01

This article explores how Hong Kong Chinese engineering students with low English language proficiency manage to cope with their lectures given in English. An ethnographic case study approach was used with multiple sources of data triangulated to provide a picture of the lecture event from both the students' and the lecturer's perspectives. One of…

iCSC2010

CERN Multimedia

IT Department

2010-01-01

The 4th edition of the Inverted CERN School of Computing (iCSC, “Where students turn into teachers”) will take place next Monday and Tuesday (8th and 9th of March) at CERN, Building 31 - IT Amphitheatre - Third Floor. Attendance is free and open to everyone. The programme is designed so that you can attend the lectures that interest you. Registration is not mandatory, but will allow you to obtain a copy of the full booklet (first registered, first served). Programme overview: Monday 8 March 10:00 - 10:15 Introduction School opening 10:15 - 11:10 Lecture 1 Introduction to UML for Developers and OO Best Practices - Tim Muenchen 11:20 - 12:15 Lecture 2 Design Patterns and Anti-Patterns - Tim Muenchen 14:00 - 14:55 Lecture 3 How to make web applications run faster - David Horat 15:05 - 16:00 Lecture 4 Distributed version control using Git: Get more efficient managing your code - David Svantesson 16:30- 17:25 Lecture 5 Recent Advances in Multivariate Data Visualisation - Benjam...

Application of Circuit Simulation Method for Differential Modeling of TIM-2 Iron Uptake and Metabolism in Mouse Kidney Cells

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Zhijian eXie

2013-06-01

Full Text Available Circuit simulation is a powerful methodology to generate differential mathematical models. Due to its highly accurate modelling capability, circuit simulation can be used to investigate interactions between the parts and processes of a cellular system. Circuit simulation has become a core technology for the field of electrical engineering, but its application in biology has not yet been fully realized. As a case study for evaluating the more advanced features of a circuit simulation tool called Advanced Design System (ADS, we collected and modeled laboratory data for iron metabolism in mouse kidney cells for a H ferritin (HFt receptor, T cell immunoglobulin and mucin domain-2 (TIM-2. The internal controlling parameters of TIM-2 associated iron metabolism were extracted and the ratios of iron movement among cellular compartments were quantified by ADS. The differential model processed by circuit simulation demonstrated a capability to identify variables and predict outcomes that could not be readily measured by in vitro experiments. For example, an initial rate of uptake of iron-loaded HFt was 2.17 pmol per million cells. TIM-2 binding probability with iron-loaded HFt was 16.6%. An average of 8.5 minutes was required for the complex of TIM-2 and iron-loaded HFt to form an endosome. The endosome containing HFt lasted roughly 2 hours. At the end of endocytosis, about 28% HFt remained intact and the rest was degraded. Iron released from degraded HFt was in the labile iron pool (LIP and stimulated the generation of endogenous HFt for new storage. Both experimental data and the model showed that TIM-2 was not involved in the process of iron export. The extracted internal controlling parameters successfully captured the complexity of TIM-2 pathway and the use of circuit simulation-based modeling across a wider range of cellular systems is the next step for validating the significance and utility of this method.

Feto-maternal immune regulation by TIM-3/galectin-9 pathway and PD-1 molecule in mice at day 14.5 of pregnancy

DEFF Research Database (Denmark)

Meggyes, Matyas; Lajko, Adrienn; Palkovics, Tamas

2015-01-01

INTRODUCTION: Immunoregulation implies the activation of negative pathways leading to the modulation of specific immune responses. Co-inhibitory receptors (such as PD-1 and TIM-3) represent possible tools for this purpose. PD-1 and TIM-3 have been demonstrated to be present on immune cells...... suggesting general involvement in immunosuppression such as fetomaternal tolerance. The aim of our study was to investigate the expression pattern of PD-1, TIM-3, and its ligand Gal-9 on different immune cell subsets in the peripheral blood and at the fetomaternal interface in pregnant mice. METHODS: TIM-3...... and PD-1 expression by peripheral and decidual immune cells from pregnant BALB-c mice in 2 weeks of gestational age were measures by flow cytometry. Placental galectin-9 expression was determined by immunohistochemically and RT-PCR. RESULTS: Gal-9 was found to be present in the spongiotrophoblast layer...

Academic Training Lecture - Regular Programme

CERN Multimedia

PH Department

2011-01-01

Regular Lecture Programme 9 May 2011 ACT Lectures on Detectors - Inner Tracking Detectors by Pippa Wells (CERN) 10 May 2011 ACT Lectures on Detectors - Calorimeters (2/5) by Philippe Bloch (CERN) 11 May 2011 ACT Lectures on Detectors - Muon systems (3/5) by Kerstin Hoepfner (RWTH Aachen) 12 May 2011 ACT Lectures on Detectors - Particle Identification and Forward Detectors by Peter Krizan (University of Ljubljana and J. Stefan Institute, Ljubljana, Slovenia) 13 May 2011 ACT Lectures on Detectors - Trigger and Data Acquisition (5/5) by Dr. Brian Petersen (CERN) from 11:00 to 12:00 at CERN ( Bldg. 222-R-001 - Filtration Plant )

A multipurpose TIM-based optical telescope for Omega and the Trident laser facilities

International Nuclear Information System (INIS)

Oertel, J.A.; Murphy, T.J.; Berggren, R.R.

1998-01-01

The authors have recently designed and are building a telescope which acts as an imaging light collector relaying the image to an optical table for experiment dependent analysis and recording. The expected primary use of this instrument is a streaked optical pyrometer for witness plate measurements of Hohlraum drive temperature. The telescope is based on University of Rochester's Ten-Inch Manipulator (TIM) which allows compatibility between Omega, Trident, and the NIF lasers. The optics capture a f/7 cone of light, have a field of view of 6-mm, have a spatial resolution of 5 to 7-microm per line pair at the object plane, and are optimized for operation at 280-nm. The image is at a magnification of 11.7x, which is convenient for many experiments, but can be changed using additional optics that reside outside the TIM

Hubungan Antara Lingkungan Kerja Dan Kerjasama Tim Dengan Kepuasan Kerja

OpenAIRE

Oktapiani, Marliza

2011-01-01

The Objectivity of study is to examine the work Environment and Teamwork in improving to lecture's job satisfaction teacher's at Raudhatul Athfal of Duren Sawit region east Jakarta. In this study, the method applied is descriptive quantitative method. Analysis unit refers lecture's job satisfaction at Raudhatul Athfal of Duren Sawit region east Jakarta . Instrument applied in collecting of data it is questioner.This study covers: (1) is the work Environment lecture's job satisfaction teacher'...

HUBUNGAN ANTARA LINGKUNGAN KERJA DAN KERJASAMA TIM DENGAN KEPUASAN KERJA

OpenAIRE

Oktapiani, Marliza

2011-01-01

The Objectivity of study is to examine the work Environment and Teamwork in improving to lecture's job satisfaction teacher's at Raudhatul Athfal of Duren Sawit region east Jakarta. In this study, the method applied is descriptive quantitative method. Analysis unit refers lecture's job satisfaction at Raudhatul Athfal of Duren Sawit region east Jakarta . Instrument applied in collecting of data it is questioner.This study covers: (1) is the work Environment lecture's job satisfaction teacher'...

Performance characteristics of a Bioassay method for plutonium using thermal ionisation mass spectrometry (TIMS)

Energy Technology Data Exchange (ETDEWEB)

Linauskas, S.H.; Elliot, N.L.; Paterson, L.M.; Totland, M.M

2003-01-01

Plutonium-in-urine analysis by radiochemical isolation of Pu followed by thermal ionisation mass spectrometry (TIMS) is capable of high sensitivity and precision measurements {sup 239}Pu and {sup 240}Pu. Bias and precision estimates for the TIMS bioassay program at Chalk River Laboratories easily met the ANSI N13.30 performance criteria standards with {sup 239}Pu results of 1.5% and 3.0%, respectively. Analytical blanks derived from water, artificial urine and true urine samples did not produce any statistically different results. During a four-year period of development and implementation of {sup 239}Pu measurements by TIMS, average sample blank values were reduced from 3.9 fg (9.0 {mu}Bq) to 0.57 fg (1.3 {mu}Bq). This reduction was achieved through rigorous application of clean-room handling techniques throughout sample processing. Blank data were found to follow a Iognormal distribution, and current detection limit parameters for L{sub c} and L{sub d} at the 95% significance levels are 0.85 fg {sup 239}Pu (2.0 {mu}Bq) and 1.3 fg {sup 239}Pu (3.0 {mu}Bq), respectively. Detection limits in this range are expected to be sufficient to identify intakes of Pu/Am mixtures at levels that are around one-twentieth of an ALl or better under routine monitoring situations for ICRP Type S and Type M inhalation solubility classes. (author)

Fulltext PDF

Indian Academy of Sciences (India)

2010-11-02

Nov 2, 2010 ... curriculum in the broad areas of non-equilibrium thermodynamics and statistical mechanics and their applications. The lectures will be followed by problem solving, discussion sessions and home assignments. Prof. D S Ray,. Department of Physical Chemistry, IACS, Kolkata is the Course Director and Profs ...

1173.pdf | may102008 | currsci | Indian Academy of Sciences

Indian Academy of Sciences (India)

How to combat infectious diseases: The role of Science Academies · Academy Public Lecture and INSA–Leopoldina Lecture by Prof. Jörg Hacker, President, German Academy of Sciences Leopoldina. 4 December, 2017, 4 PM Faculty Hall, Indian Institute ...

JESS-D-16-00343 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

How to combat infectious diseases: The role of Science Academies · Academy Public Lecture and INSA–Leopoldina Lecture by Prof. Jörg Hacker, President, German Academy of Sciences Leopoldina. 4 December, 2017, 4 PM Faculty Hall, Indian Institute ...

epubworkshop | Indian Academy of Sciences

Indian Academy of Sciences (India)

How to combat infectious diseases: The role of Science Academies · Academy Public Lecture and INSA–Leopoldina Lecture by Prof. Jörg Hacker, President, German Academy of Sciences Leopoldina. 4 December, 2017, 4 PM Faculty Hall, Indian Institute ...

Laughter in University Lectures

Science.gov (United States)

Nesi, Hilary

2012-01-01

This paper analyses laughter in spoken academic discourse, with the aim of discovering why lecturers provoke laughter in their lectures. A further purpose of the paper is to identify episodes in British data which may differ from those in other cultural contexts where other lecturing practices prevail, and thus to inform the design of study skills…

Forum: The Lecture and Student Learning. The Lecture's Absent Audience

Science.gov (United States)

Sciullo, Nick J.

2017-01-01

According to the "Oxford English Dictionary" ("OED"), the noun "lecture" dates from the 14th century and means the "action of reading, perusal. Also, that which is read or perused." This definition, while accurate and resonates today in many college classrooms, ignores a key feature of any lecture. The…

A Geminoid as Lecturer

DEFF Research Database (Denmark)

Abildgaard, Julie Rafn; Schärfe, Henrik

2012-01-01

In this paper we report our findings from an experiment with the teleoperated android Geminoid-DK. The geminoid took up the role of a university lecturer and delivered a 45 minute lecture in front of 150 freshmen students at Aalborg University. While considering the role of the geminoid in this e......In this paper we report our findings from an experiment with the teleoperated android Geminoid-DK. The geminoid took up the role of a university lecturer and delivered a 45 minute lecture in front of 150 freshmen students at Aalborg University. While considering the role of the geminoid...

Determination of La and Nd by thermal ionization mass spectrometry (TIMS) pre-separated by high performance liquid chromatography (HPLC)

International Nuclear Information System (INIS)

Jaison, P.G.; Raut, N.M.; Parab, A.R.; Khodade, P.S.; Govindan, R.; Aggarwal, S.K.

2003-01-01

Determination of La and Nd by TIMS is required for accurate determination of burn-up of nuclear fuels. During their thermal ionization mass spectrometric (TIMS) analysis, 138 Ce and 142 Ce show spectroscopic isobaric interferences at 138 La and 142 Nd, respectively. Hence, it is essential to remove Ce from La and Nd for their accurate isotopic composition determination. Reversed phase high performance liquid chromatography (HPLC) is a promising technique for rapid and effective separation

Cultura digital jovem: as TIMS invadem as periferias, e agora?

Directory of Open Access Journals (Sweden)

Márcia Gonçalves Nogueira

2014-08-01

Full Text Available Objective of this work is to present a literature review on Young and the Digital Cultural transformations caused by the dissemination of Information Technology and Communication Mobile and wireless (TIMS on the outskirts of the metropolitan area of Recife. To this end, we seek to identify how young periphery, high school students of a public school, they experience the Digital Culture in different social spaces; among them the school, scene of many tensions and generational conflicts and language as social and cultural use of these mobile devices. We highlight some theoretical approaches to the phenomenon of mobile communication and the concept of Digital Culture, adopted in this work. Proposing a reflection on the role of school in the current social context of constant cultural and linguistic transformations multimodality of the digital age. Finally, we present an exercise of looking on Youth Cultures, from different theoretical, to better understand the multiple transits covered by surveyed youth to express themselves and make sense of their audiovisual productions, mediated by TIMS. This theoretical argument was used in the dissertation in mathematics education and technology by one of the authors of this article. Therefore, we hope to contribute to further research on Digital Youth Culture in the context of the periphery.

Space Solar Power Technical Interchange Meeting 2: SSP TIM 2

Science.gov (United States)

Sanders, Jim; Hawk, Clark W.

1998-01-01

The 2nd Space Solar Power Technical Interchange Meeting (SSP TIM 2) was conducted September 21st through 24th with the first part consisting of a Plenary session. The summary results of this Plenary session are contained in part one of this report. The attendees were then organized into Working Breakout Sessions and Integrated Product Team (IPT) Sessions for the purpose of conducting in-depth discussions in specific topic areas and developing a consensus as to appropriate study plans and actions to be taken. The Second part covers the Plenary Summary Session, which contains the summary results of the Working Breakout Sessions and IPT Sessions. The appendix contains the list of attendees. The ob'jective was to provide an update for the study teams and develop plans for subsequent study activities. This SSP TIM 2 was initiated and the results reported electronically over the Internet. The International Space Station (ISS) could provide the following opportunities for conducting research and technology (R&T) which are applicable to SSP: (1) Automation and Robotics, (2) Advanced Power Generation, (3) Advanced Power Management & Distribution (PMAD), (4) Communications Systems and Networks, (5) Energy Storage, (6) In Space Propulsion (ISP), (7) Structural Dynamics and Control, and Assembly and (8) Wireless Power Transmission.

Physics Conference TIM-15-16

CERN Document Server

2016-01-01

The Conference is organized by the West University of Timisoara, Faculty of Physics. The scientific program of the conference will include invited lectures, oral and poster presentations, as well as discussions on various topics of present interest, such as, but not limited to condensed matter physics and applications, theoretical and computational physics, and applied physics.

Project TIMS (Teaching Integrated Math/Science)

Science.gov (United States)

Edwards, Leo, Jr.

1993-01-01

The goal of this project is to increase the scientific knowledge and appreciation bases and skills of pre-service and in-service middle school teachers, so as to impact positively on teaching, learning, and student retention. This report lists the objectives and summarizes the progress thus far. Included is the working draft of the TIMS (Teaching Integrated Math/Science) curriculum outline. Seven of the eight instructional subject-oriented modules are also included. The modules include informative materials and corresponding questions and educational activities in a textbook format. The subjects included here are the universe and stars; the sun and its place in the universe; our solar system; astronomical instruments and scientific measurements; the moon and eclipses; the earth's atmosphere: its nature and composition; and the earth: directions, time, and seasons. The module not included regards winds and circulation.

Järgmise lainega võivad tulla meile Ühendriikide investorid / Tim Ferland ; interv. Margit Aedla

Index Scriptorium Estoniae

Ferland, Tim

2003-01-01

Eestis asuva Ameerika Kaubanduskoja (ACCE) president Tim Ferland analüüsib Eesti senist arengut, EL-iga liitumise mõju tulevasele majanduslikule arengule, Eesti ning USA majandus- ja kaubandussuhete olukorda

U-series dating using thermal ionisation mass spectrometry (TIMS)

Energy Technology Data Exchange (ETDEWEB)

McCulloch, M.T. [Australian National University, Canberra, ACT (Australia). Research School of Earth Science

1999-11-01

U-series dating is based on the decay of the two long-lived isotopes{sup 238}U({tau}{sub 1/2}=4.47 x 10{sup 9} years) and {sup 235}U ({tau}{sub 1/2} 0.7 x 10{sup 9} years). {sup 238}U and its intermediate daughter isotopes {sup 234}U ({tau}{sub 1/2} = 245.4 ka) and {sup 230}Th ({tau}{sub 1/2} = 75.4 ka) have been the main focus of recently developed mass spectrometric techniques (Edwards et al., 1987) while the other less frequently used decay chain is based on the decay {sup 235}U to {sup 231}Pa ({tau}{sub 1/2} = 32.8 ka). Both the {sup 238}U and {sup 235}U decay chains terminate at the stable isotopes {sup 206}Pb and {sup 207}Pb respectively. Thermal ionization mass spectrometry (TIMS) has a number of inherent advantages, mainly the ability to measure isotopic ratios at high precision on relatively small samples. In spite of these now obvious advantages, it is only since the mid-1980`s when Chen et al., (1986) made the first precise measurements of {sup 234}U and {sup 232}Th in seawater followed by Edwards et al., (1987) who made combined {sup 234}U-{sup 230}Th measurements, was the full potential of mass spectrometric methods first realised. Several examples are given to illustrate various aspects of TIMS U-series 9 refs., 3 figs.

“This is you”: Encountering Shakespeare with Tim Crouch

Directory of Open Access Journals (Sweden)

Sara Soncini

2017-11-01

Full Text Available This essay considers Tim Crouch's "I Shakespeare", a suite of monologue plays based on "The Tempest" ("I, Caliban", 2003, "A Midsummer Night's Dream" ("I, Peaseblossom", 2004, "Macbeth" ("I, Banquo", 2005, "Twelfth Night" ("I, Malvolio", 2010 and "Julius Caesar" ("I, Cinna (the poet", 2012. While originally designed for a young audience, Crouch's adaptations have been performed in a variety of theatrical contexts that have added new and probably unforeseen dimensions to their negotiations with Shakespeare. In my analysis I turn to the notion of mobility as a key analytical tool to elucidate the method, aims, as well as the broader cultural meaning of Tim Crouch's reworkings. In his hands, Shakespeare is mobilized as a powerful resource to activate spectators and emphasize their co-authorship in the process of theatre. Through a combination of textual strategies and performance methods, the monologues construct the identities of Shakespeare's characters as multiple and mutable and, in parallel, cast their addressees in fluid, often contradictory roles. My main line of argument is that the plays' propensity of motion is rooted in their emphasis on Shakespeare as a highly mobile cultural signifier which seems confirmed by the monologues' journeys outside the UK. The further adaptational practices triggered by these encounters with foreign audiences are testament to the flexibility of Crouch's dramaturgy of process and its aptitude to accommodate new discursive identities and adjust to each new context of reception.

Message in a bottle: learning our way out of unsustainability

OpenAIRE

Wals, A.E.J.

2010-01-01

Inaugural lecture of Prof. dr. ir. Arjen E.J. Wals upon taking up the posts of Professor of Social Learning and Sustainable Development, and UNESCO Chair at Wageningen University on May 27th 2010. Lecture about the consequences of unsustainable usage of plastics.

Public Lectures | Events | Indian Academy of Sciences

Indian Academy of Sciences (India)

Public and special lectures. Academy Public Lectures · Public and special lectures in Mid-Year and Annual Meetings · Platinum Jubilee Lectures. Academy's annual and mid-year meetings include a special lecture by a senior Fellow in the morning of each meeting day and one public lecture by an eminent person, from ...

Investigation of T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) polymorphisms in essential thrombocythaemia (ET).

Science.gov (United States)

Han, Fuyan; Wang, Guanghai; Li, Yuantang; Tian, Wenjun; Dong, Zhenfang; Cheng, Shiqing; Liu, Yiqing; Qu, Teng; Wang, Xiaoying; Wang, Yong; Zhang, Bingchang; Ju, Ying

2017-07-01

T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) is preferentially expressed on terminally differentiated Th1 cells and inhibits their IFN-γ production. It has been reported that chronic inflammation may be an important driving force for myeloproliferative neoplasms (MPNs). Therefore, we hypothesized that as an important inflammation regulator, TIM-3 may be involved in essential thrombocythaemia (ET). The goal of this study was to investigate whether the -1516G > T, -574G > T and +4259T > G single-nucleotide polymorphisms (SNPs) within the TIM-3 gene contribute to the genetic susceptibility of individuals to ET. Genotyping of the TIM-3 -1516G > T, -574G > T and + 4259T > G SNPs was performed in 175 patients with ET and in 151 controls via a polymerase chain reaction-restriction fragment length polymorphism assay. We also investigated the relationships between the genotypes of each SNP and the risk factors of ET such as routine blood indexes, age and JAK2 V617F mutation. The genotype and allele frequencies of the -1516G > T SNP (p = 0.016 and 0.019, respectively), the -574G > T SNP (p = 0.035 and 0.038, respectively) and the +4259T > G SNP (p = 0.036 and 0.038, respectively) of the ET patients and the controls were significantly different. A haplotype analysis found that the GGT and TGT haplotypes had significantly different distributions between ET and controls (p = 0.041 and 0.041, respectively). However, no significant differences were detected between the genotypes of all SNPs and routine blood indexes, age and JAK2V617F mutation. The -1516G > T, -574G > T and +4259T > G SNPs within TIM-3 gene might play an important role as a genetic risk factor in the pathogenesis of ET.

In memory Prof. Dr. L.H.K Bleeker | Gemser | HTS Teologiese ...

African Journals Online (AJOL)

HTS Teologiese Studies / Theological Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 1, No 3 (1944) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. In memory Prof. Dr. L.H.K Bleeker. B Gemser ...

Regulatory effect of gamma-chain cytokines on expression of TIM-3 on CD8+ T cells in patients with chronic hepatitis B

Directory of Open Access Journals (Sweden)

DONG Jie

2015-02-01

Full Text Available ObjectiveTo measure the expression of T-cell immunoglobulin- and mucin domain-3-containing molecule 3 (TIM-3 on CD8+ T cells in peripheral blood mononuclear cells (PBMCs among patients with chronic hepatitis B (CHB and to investigate the effect of common gamma-chain cytokines on the expression of TIM-3 on CD8+ T cells in these patients. MethodsFifteen previously untreated patients with CHB who visited the Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, from January to May, 2014, as well as 8 healthy controls, were included in the study. Blood was collected from these subjects, and PBMCs were isolated from blood by Ficoll density gradient centrifugation. PBMCs were separately stimulated with gamma-chain cytokines, interleukin (IL2, IL-7, IL-15, and IL-21, and anti-CD3/CD28, and the untreated cells were used as a negative control. After four days of culture, PBMCs were stained with monoclonal antibody. Flow cytometry was used to measure the expression of TIM-3 on CD8+ T cells. Comparison of continuous data was made by independent-samples t test. ResultsCompared with the untreated group, the anti-CD3/CD28, IL-2, IL-15, and IL-7 groups had significantly increased expression of TIM-3 on CD8+ T cells (9.629%±9.916%, P=0000 1; 3.817%±2.694%, P = 0.000 6; 5.772%±4.732%, P = 0.005 4; 3.560%±2.045%, P = 0.030 2, while the IL-21 group had nonsignificantly increased expression of TIM-3 on CD8+ T cells (2.503%±2.117%, P = 0.934 1. ConclusionAnti-CD3/CD28 and gamma-chain cytokines IL-2, IL-7, and IL-15 can effectively upregulate the expression of TIM-3 on CD8+ T cells in patients with CHB. It indicates that the inhibition of them can not only reduce the expression of TIM-3, but also may enhance the killing function of CD8+ T cells in patients with CHB.

Tim, Jan Lucas ja Karl Robert - vennad üheks kuuks / Maris Laurits

Index Scriptorium Estoniae

Laurits, Maris

2009-01-01

Rakvere Teatri suvelavastuse "Vennad Lõvisüdamed" kaks Karli osatäitjat Jan Lucas Videvik ja Tim Leesnurm ning Joonatani osatäitja Karl Robert Saaremäe tegid Loksal Kaldmaa talus ratsasõiduproove. Üllar Saaremäe lavastuse "Vennad Lõvisüdamed" (Astrid Lindgreni samanimelise jutustuse järgi) esietendus on 11. juunil Rakvere teatri taga aias

ACADEMIC TRAINING LECTURE

CERN Multimedia

Academic Training; Tel. 73127

2001-01-01

12, 13, 14, 15 & 16 March REGULAR LECTURE PROGRAMME From 11:00 hrs - Main Auditorium bldg. 500 Telecommunication for the future Rob Parker / CERN-IT Few fields have experienced such a high level of technical advance over the last few decades as that of telecommunications. This lecture series will track the evolution of telecommunications systems since their inception, and consider how technology is likely to advance over the next years. A personal view will also be given of the effect of these innovations on our work and leisure activities.The lecture series will be aimed at an audience with no specific technical knowledge of telecommunications.

CERN Multimedia

HR Department

2010-01-01

LECTURE SERIES 9, 10 11 & 12 March 2010 11:00-12:00 - Main Auditorium, Bldg. 500 The Dark Side of the Universe: Dark Matter and Dark Energy by Prof. Michael Turner Tuesday 9 June 2009 Lecture 1 : State of Cosmology Today Wednesday 10 June 2009 Lecture 2: Particle Dark Matter Thursday 11 June 2009 Lecture 3: Cosmic Acceleration and Dark Energy Friday 12 June 2009 Lecture 4: Future Direction and Challenges Organiser: Maureen Prola-Tessaur/PH-EDU

Lectures on string theory

International Nuclear Information System (INIS)

Thorn, C.B.

1988-01-01

Several topics are discussed in string theory presented as three lectures to the Spring School on Superstrings at the ICTP at Trieste, Italy, in April, 1988. The first lecture is devoted to some general aspects of conformal invariance and duality. The second sketches methods for carrying out perturbative calculations in string field theory. The final lecture presents an alternative lattice approach to a nonperturbative formulation of the sum over world surfaces. 35 refs., 12 figs

Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression.

Science.gov (United States)

Dong, Jianfeng; Cheng, Lijun; Zhao, Minchao; Pan, Xiangfeng; Feng, Zhiqiang; Wang, Dawei

2017-05-01

Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development. Strong antitumor immune responses, especially CD8 + T cell responses, are thought to be essential to effective cancer treatment and are associated with better prognosis in oropharyngeal head and neck squamous cell carcinoma. In this study, we examined the role of the Tim-3/Gal-9 pathway in oropharyngeal head and neck squamous cell carcinoma patients. We found that Gal-9 expression by CD4 + T cells was increased in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients, but not in human papillomavirus-negative oropharyngeal head and neck squamous cell carcinoma patients. Increased Gal-9 secretion by CD4 + T cells presented multiple immunosuppressive effects. Coculturing monocytes with high Gal-9-expressing CD4 + T cells resulted in the expansion of Tim-3 + monocytes, which suppressed interferon gamma production by activated CD8 + T cells. Subsequently, total monocytes incubated with exogenous Gal-9, or high Gal-9-expressing CD4 + T cells, suppressed the expression of interferon gamma by CD8 + T cells. Exogenous Gal-9 and high Gal-9-expressing CD4 + T cells also suppressed the secretion of both interleukin 10 and interleukin 12 by monocytes. These effects are Tim-3/Gal-9-dependent because blocking Tim-3 and/or Gal-9 could enhance the support of CD8 + T cell interferon gamma production and the interleukin 10 and interleukin 12 secretion by monocytes. Together, these data suggest that the high Tim-3 expression in monocytes could be utilized by tumor-promoting Gal-9 expression on CD4 + T cells. Immunotherapy in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients therefore faces an additional challenge posed by Tim-3 and Gal-9 and likely requires the blockade of these

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

Directory of Open Access Journals (Sweden)

Isabel Gonçalves Silva

2017-08-01

Full Text Available Acute myeloid leukemia (AML is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered a fundamental molecular pathway, which includes ligand-dependent activation of ectopically expressed latrophilin 1 and possibly other G-protein coupled receptors leading to increased translation and exocytosis of the immune receptor Tim-3 and its ligand galectin-9. This occurs in a protein kinase C and mTOR (mammalian target of rapamycin-dependent manner. Tim-3 participates in galectin-9 secretion and is also released in a free soluble form. Galectin-9 impairs the anti-cancer activity of cytotoxic lymphoid cells including natural killer (NK cells. Soluble Tim-3 prevents secretion of interleukin-2 (IL-2 required for the activation of cytotoxic lymphoid cells. These results were validated in ex vivo experiments using primary samples from AML patients. This pathway provides reliable targets for both highly specific diagnosis and immune therapy of AML.

PROF. DR. M. FAHRETTİN KIRZIOĞLU’ NUN BAZI MÜCADELELERİ VE MEKTUPLARINDAN İKTİBASLAR

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Kırzıoğlu, Banıçiçek

2010-01-01

ÖZETMakale, Türkolog Prof. Dr. M. Fahrettin Kırzıoğlu’nun , kardeşi M. Cemal Kırzıoğlu’na yazdığı bazı mektuplarından alıntılar ile; bu mektuplardan tespit edilebilen bir kısım mücadelelerini ihtiva etmektedir. ABSTRACTThis study includes some quotations from the letters that a Turcologist Prof. Dr. M.Fahrettin Kırzıoğlu wrote to his brother M. Cemal Kırzıoğlu and some of his contention determined through these letters.

Modification of the Near Surface Region Metastable Phases and Ion Induced Reactions

Science.gov (United States)

1984-02-03

cell Si Dave Lilienfeld - amorphous Si layer thickness Au diffusion in metallic glasses Dave Lilienfeld & - low temperature Cu diffusion in Si Tim...Sullivan Fritz Stafford - defect characterization in implanted & annealed silicon-on-sapphire Peter Zielinski - Composition of CuZr metallic glass...ribbons 5. Prof. Johnson Dave Kuhn - measurement of Pd layer thickness Alexandra Elve - hydrogen profiles in metals Lauren Heitner - hydrogen diffusion in

SPIG From Beginning To Today

Science.gov (United States)

Labat, J.

2010-07-01

Rapid growth of nuclear physics in fifties attracted attention of numerous scientists, mainly physicists. At the same time, governments become interested in the field, expecting various advantages, and to be honest, in the first place the nuclear weapons. As a result, also in the country at that time called Yugoslavia, the Federal Nuclear Agency has been formed, and generously funds have been given to support the research. In Yugoslavia three nuclear centers have been founded: in Belgrade (Serbia), Zagreb (Croatia) and Ljubljana (Slovenia). The nuclear research and applications to related fields, inevitably was related to the physics of ionized gases. Just to mention electro-magnetic separation of isotopes, mass spectrometry, gas filled nuclear radiation detectors, accelerator ion sources, sources for analytical spectroscopy and others. Right from the beginning a common problem has been met: lack of basic knowledge on elementary collision processes and in general on the matter in ionized state. Groups of physicists in the mentioned institutes have started paying full attention to these problems. They found it of interest to exchange the results and cooperate not only between themselves but also with research centers in other countries. It was felt that at least one national meeting should be organized, where an overview of activities in the field of ionized gases could be presented. Thanks to extraordinary efforts of prof. B. Perovic, supported, backed and simulated by prof. A. Milojevic, prof. Z. Sternberg, prof. Dj. Bosan and prof. A. Moljk first such meeting was prepared. In 1962 the "Ist Yugoslav Symposium an the Physics of Ionized Gases" was organized in Belgrade. Six invited lectures and 26 original contributions were presented. Two years later, in 1964, the second meeting of the same title was held in Zagreb (Croatia). The large number of participants and unexpected interest in field has initiated an idea that the study of different fields related to the

Structural analysis on mutation residues and interfacial water molecules for human TIM disease understanding

Science.gov (United States)

2013-01-01

Background Human triosephosphate isomerase (HsTIM) deficiency is a genetic disease caused often by the pathogenic mutation E104D. This mutation, located at the side of an abnormally large cluster of water in the inter-subunit interface, reduces the thermostability of the enzyme. Why and how these water molecules are directly related to the excessive thermolability of the mutant have not been investigated in structural biology. Results This work compares the structure of the E104D mutant with its wild type counterparts. It is found that the water topology in the dimer interface of HsTIM is atypical, having a "wet-core-dry-rim" distribution with 16 water molecules tightly packed in a small deep region surrounded by 22 residues including GLU104. These water molecules are co-conserved with their surrounding residues in non-archaeal TIMs (dimers) but not conserved across archaeal TIMs (tetramers), indicating their importance in preserving the overall quaternary structure. As the structural permutation induced by the mutation is not significant, we hypothesize that the excessive thermolability of the E104D mutant is attributed to the easy propagation of atoms' flexibility from the surface into the core via the large cluster of water. It is indeed found that the B factor increment in the wet region is higher than other regions, and, more importantly, the B factor increment in the wet region is maintained in the deeply buried core. Molecular dynamics simulations revealed that for the mutant structure at normal temperature, a clear increase of the root-mean-square deviation is observed for the wet region contacting with the large cluster of interfacial water. Such increase is not observed for other interfacial regions or the whole protein. This clearly suggests that, in the E104D mutant, the large water cluster is responsible for the subunit interface flexibility and overall thermolability, and it ultimately leads to the deficiency of this enzyme. Conclusions Our study

High-precision isotopic characterization of USGS reference materials by TIMS and MC-ICP-MS

Science.gov (United States)

Weis, Dominique; Kieffer, Bruno; Maerschalk, Claude; Barling, Jane; de Jong, Jeroen; Williams, Gwen A.; Hanano, Diane; Pretorius, Wilma; Mattielli, Nadine; Scoates, James S.; Goolaerts, Arnaud; Friedman, Richard M.; Mahoney, J. Brian

2006-08-01

The Pacific Centre for Isotopic and Geochemical Research (PCIGR) at the University of British Columbia has undertaken a systematic analysis of the isotopic (Sr, Nd, and Pb) compositions and concentrations of a broad compositional range of U.S. Geological Survey (USGS) reference materials, including basalt (BCR-1, 2; BHVO-1, 2), andesite (AGV-1, 2), rhyolite (RGM-1, 2), syenite (STM-1, 2), granodiorite (GSP-2), and granite (G-2, 3). USGS rock reference materials are geochemically well characterized, but there is neither a systematic methodology nor a database for radiogenic isotopic compositions, even for the widely used BCR-1. This investigation represents the first comprehensive, systematic analysis of the isotopic composition and concentration of USGS reference materials and provides an important database for the isotopic community. In addition, the range of equipment at the PCIGR, including a Nu Instruments Plasma MC-ICP-MS, a Thermo Finnigan Triton TIMS, and a Thermo Finnigan Element2 HR-ICP-MS, permits an assessment and comparison of the precision and accuracy of isotopic analyses determined by both the TIMS and MC-ICP-MS methods (e.g., Nd isotopic compositions). For each of the reference materials, 5 to 10 complete replicate analyses provide coherent isotopic results, all with external precision below 30 ppm (2 SD) for Sr and Nd isotopic compositions (27 and 24 ppm for TIMS and MC-ICP-MS, respectively). Our results also show that the first- and second-generation USGS reference materials have homogeneous Sr and Nd isotopic compositions. Nd isotopic compositions by MC-ICP-MS and TIMS agree to within 15 ppm for all reference materials. Interlaboratory MC-ICP-MS comparisons show excellent agreement for Pb isotopic compositions; however, the reproducibility is not as good as for Sr and Nd. A careful, sequential leaching experiment of three first- and second-generation reference materials (BCR, BHVO, AGV) indicates that the heterogeneity in Pb isotopic compositions

DR. MIKA MAJALE MEMORIAL LECTURE

African Journals Online (AJOL)

He had four children Irene Majale,. Prof. Mike Majale (Architect) Victoria Majale Ojiambo and Chris Majale. Dr. Majale died on 21st April 1978. As an orthopaedic Surgeon he worked at Kenyatta. National Hospital (KNH), Kabete Orthopaedic Unit and. Armed Forces Memorial Hospital. He did not do any private practice.

The Oskar Klein memorial lectures

CERN Document Server

1994-01-01

The series of Oskar Klein Memorial Lectures is a must-read for those keenly involved or simply interested in exploring the many fascinating aspects of Physics. This volume presents two landmark lectures given by Hans Bethe in October 1990 and Alan H. Guth in June 1991 under the series of Oskar Klein Memorial Lectures. Hans Bethe's lectures dealt with two themes: the astrophysical importance of neutrinos in supernova outbursts and a theoretical account of neutrinos through observations of the neutrino flux from the centre of the sun. Anyone interested in understanding the processes involved in

Tim Peake and Britain's road to space

CERN Document Server

Seedhouse, Erik

2017-01-01

This book puts the reader in the flight suit of Britain’s first male astronaut, Tim Peake. It chronicles his life, along with the Principia mission and the down-to-the-last-bolt descriptions of life aboard the ISS, by way of the hurdles placed by the British government and the rigors of training at Russia’s Star City military base. In addition, this book discusses the learning curves required in astronaut and mission training and the complexity of the technologies required to launch an astronaut and keep them alive for months on end. This book underscores the fact that technology and training, unlike space, do not exist in a vacuum; complex technical systems, like the ISS, interact with the variables of human personality, and the cultural background of the astronauts. .

Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9.

Science.gov (United States)

Schwartz, Jordan Ari; Clayton, Kiera L; Mujib, Shariq; Zhang, Hongliang; Rahman, A K M Nur-Ur; Liu, Jun; Yue, Feng Yun; Benko, Erika; Kovacs, Colin; Ostrowski, Mario A

2017-04-15

In chronic diseases, such as HIV infection, plasmacytoid dendritic cells (pDCs) are rendered dysfunctional, as measured by their decreased capacity to produce IFN-α. In this study, we identified elevated levels of T cell Ig and mucin-domain containing molecule-3 (Tim-3)-expressing pDCs in the blood of HIV-infected donors. The frequency of Tim-3-expressing pDCs correlated inversely with CD4 T cell counts and positively with HIV viral loads. A lower frequency of pDCs expressing Tim-3 produced IFN-α or TNF-α in response to the TLR7 agonists imiquimod and Sendai virus and to the TLR9 agonist CpG. Thus, Tim-3 may serve as a biomarker of pDC dysfunction in HIV infection. The source and function of Tim-3 was investigated on enriched pDC populations from donors not infected with HIV. Tim-3 induction was achieved in response to viral and artificial stimuli, as well as exogenous IFN-α, and was PI3K dependent. Potent pDC-activating stimuli, such as CpG, imiquimod, and Sendai virus, induced the most Tim-3 expression and subsequent dysfunction. Small interfering RNA knockdown of Tim-3 increased IFN-α secretion in response to activation. Intracellular Tim-3, as measured by confocal microscopy, was dispersed throughout the cytoplasm prior to activation. Postactivation, Tim-3 accumulated at the plasma membrane and associated with disrupted TLR9 at the submembrane. Tim-3-expressing pDCs had reduced IRF7 levels. Furthermore, intracellular Tim-3 colocalized with p85 and IRF7 within LAMP1 + lysosomes, suggestive of a role in degradation. We conclude that Tim-3 is a biomarker of dysfunctional pDCs and may negatively regulate IFN-α, possibly through interference with TLR signaling and recruitment of IRF7 and p85 into lysosomes, enhancing their degradation. Copyright © 2017 by The American Association of Immunologists, Inc.

Lecture Attendance and Web Based Lecture Technologies: A Comparison of Student Perceptions and Usage Patterns

Science.gov (United States)

von Konsky, Brian R.; Ivins, Jim; Gribble, Susan J.

2009-01-01

This paper investigates the impact of web based lecture recordings on learning and attendance at lectures. Student opinions regarding the perceived value of the recordings were evaluated in the context of usage patterns and final marks, and compared with attendance data and student perceptions regarding the usefulness of lectures. The availability…

Fulltext PDF

Indian Academy of Sciences (India)

IAS Admin

lecture, including connections with completely nonrandom problems like calculating electrostatic potential inside a region. It is indeed appropriate that that audience of mathematics teachers were exposed to an expert view of a rich field, and we are happy to reach many more by reprinting Prof. Parthasarathy's lecture.

A novel method for sampling the suspended sediment load in the tidal environment using bi-directional time-integrated mass-flux sediment (TIMS) samplers

Science.gov (United States)

Elliott, Emily A.; Monbureau, Elaine; Walters, Glenn W.; Elliott, Mark A.; McKee, Brent A.; Rodriguez, Antonio B.

2017-12-01

Identifying the source and abundance of sediment transported within tidal creeks is essential for studying the connectivity between coastal watersheds and estuaries. The fine-grained suspended sediment load (SSL) makes up a substantial portion of the total sediment load carried within an estuarine system and efficient sampling of the SSL is critical to our understanding of nutrient and contaminant transport, anthropogenic influence, and the effects of climate. Unfortunately, traditional methods of sampling the SSL, including instantaneous measurements and automatic samplers, can be labor intensive, expensive and often yield insufficient mass for comprehensive geochemical analysis. In estuaries this issue is even more pronounced due to bi-directional tidal flow. This study tests the efficacy of a time-integrated mass sediment sampler (TIMS) design, originally developed for uni-directional flow within the fluvial environment, modified in this work for implementation the tidal environment under bi-directional flow conditions. Our new TIMS design utilizes an 'L' shaped outflow tube to prevent backflow, and when deployed in mirrored pairs, each sampler collects sediment uniquely in one direction of tidal flow. Laboratory flume experiments using dye and particle image velocimetry (PIV) were used to characterize the flow within the sampler, specifically, to quantify the settling velocities and identify stagnation points. Further laboratory tests of sediment indicate that bidirectional TIMS capture up to 96% of incoming SSL across a range of flow velocities (0.3-0.6 m s-1). The modified TIMS design was tested in the field at two distinct sampling locations within the tidal zone. Single-time point suspended sediment samples were collected at high and low tide and compared to time-integrated suspended sediment samples collected by the bi-directional TIMS over the same four-day period. Particle-size composition from the bi-directional TIMS were representative of the array of

Integrated Modeling System for Analysis of Watershed Water Balance: A Case Study in the Tims Branch Watershed, South Carolina

Science.gov (United States)

Setegn, S. G.; Mahmoudi, M.; Lawrence, A.; Duque, N.

2015-12-01

The Applied Research Center at Florida International University (ARC-FIU) is supporting the soil and groundwater remediation efforts of the U.S. Department of Energy (DOE) Savannah River Site (SRS) by developing a surface water model to simulate the hydrology and the fate and transport of contaminants and sediment in the Tims Branch watershed. Hydrological models are useful tool in water and land resource development and decision-making for watershed management. Moreover, simulation of hydrological processes improves understanding of the environmental dynamics and helps to manage and protect water resources and the environment. MIKE SHE, an advanced integrated modeling system is used to simulate the hydrological processes of the Tim Branch watershed with the objective of developing an integrated modeling system to improve understanding of the physical, chemical and biological processes within the Tims Branch watershed. MIKE SHE simulates water flow in the entire land based phase of the hydrological cycle from rainfall to river flow, via various flow processes such as, overland flow, infiltration, evapotranspiration, and groundwater flow. In this study a MIKE SHE model is developed and applied to the Tim branch watershed to study the watershed response to storm events and understand the water balance of the watershed under different climatic and catchment characteristics. The preliminary result of the integrated model indicated that variation in the depth of overland flow highly depend on the amount and distribution of rainfall in the watershed. The ultimate goal of this project is to couple the MIKE SHE and MIKE 11 models to integrate the hydrological component in the land phase of hydrological cycle and stream flow process. The coupled MIKE SHE/MIKE 11 model will further be integrated with an Ecolab module to represent a range of water quality, contaminant transport, and ecological processes with respect to the stream, surface water and groundwater in the Tims

Society News: Queen honours Fellows; The Society and legacies; Thesis prizes; Lectures on laptops; Stonehenge story

Science.gov (United States)

2007-08-01

The Queen's Birthday Honours list announced on 16 June contained some familiar names from astronomy. Prof. Mark Bailey (1) of Armagh Observatory, currently a Vice-President of the RAS, was awarded an MBE and Dr Heather Couper (2), former President of the British Astronomical Association, a CBE. Prof. Nigel Mason (3) of the Open University and inaugural Director of the Milton Keynes Science Festival received an OBE. Prof. Jocelyn Bell-Burnell (4), President of the RAS from 2002-2004, was awarded a DBE - and an Honorary Doctorate from Harvard University. In addition, Prof. Lord Rees (5), Astronomer Royal, president of the Royal Society and President of the RAS from 1992-1994, was appointed to the Order of Merit.

Effect Of Accounting Lecturer Lecturer Commitment To The Development Of Professional Accounting Empirical Study Lecturer Accounting Faculty Of Economics University Of Muhammadiyah Tangerang 2013

Directory of Open Access Journals (Sweden)

Endraria

2015-04-01

Full Text Available Abstract The purpose of the study in which the researcher is interested in conducting research by taking the title The Effect of Commitment Against Lecturer - Lecturer in Accounting Accounting Profession Development Empirical Study of Accounting Lecturer Faculty of Economics University of Muhammadiyah Tangerang in 2013 . This research was conducted at the Faculty of Economics University of Muhammadiyah Tangerang is located at Independence Pioneer Road I No.33 Cikokol Tangerang City. The experiment was conducted at the research site easily accessible for the author. The method used in this research is descriptive quantitative methods which aim to describe the descriptive method of data distribution of each variable.There are significant accounting lecturers commitment to the development of the accounting profession Empirical Study of Accounting Lecturer Faculty of Economics University of Muhammadiyah Tangerang in 2013 this is evidenced by the results of hypothesis testing that has been done obtained tcount ttable value 5.7193 and with a significance level of 5 and df n - 2 40-2 38 is equal to 1.686 with the statement concluded that t count t table. Thus Ha Ho accepted and rejected. The conclusion was that there are significant accounting lecturers commitment to the development of the accounting profession Empirical Study of Accounting Lecturer Faculty of Economics University of Muhammadiyah Tangerang in 2013. As for advice to be conveyed in this study is the government as a regulator should be able to evaluate the development of the accounting profession especially in Indonesia with the influence of commitment accounting lecturers are expected to improve and develop the accounting profession especially in the Faculty of Economics University of Muhammadiyah Tangerang.

Lectures in medical educaton: what students think?

Science.gov (United States)

Mustafa, Tajammal; Farooq, Zerwa; Asad, Zunaira; Amjad, Rabbia; Badar, Iffat; Chaudhry, Abdul Majeed; Khan, Mohammad Amer Zaman; Rafique, Farida

2014-01-01

The volume of medical knowledge has increased exponentially and so has the need to improve the efficiency of current teaching practices.With increasing emphasis on interactive and problem based learning, the place of lectures in modern medical education has become a questionable issue. Objectives were to assess the perspective of undergraduate medical students regarding the role and effectiveness of lectures as a mode of instruction as well as the ways and means that can be employed to enhance the effectiveness of lectures. A cross sectional study was carried out among 2nd to final year medical students from five medical colleges including both private and public sector institutions. A total of 347 students participated by completing a structured questionnaire. Data was analyzed using SPSS-17. Sixty seven percent students considered lectures as a useful mode of instruction (47% males and 77% females), whereas 83% of the students reported that clinical sessions were superior to lectures because of small number of students in clinical sessions, active student participation, enhanced clinical orientation, and interaction with patients. About 64% responded that lectures should be replaced by clinical sessions. Majority of the students (92%) reported not being able to concentrate during a lecture beyond 30 minutes, whereas 70% skipped lectures as they were boring. A significantly greater proportion of male respondents, students from clinical years, and those who skipped lectures, considered lectures to be boring, a poor utilization of time and resources, and could not concentrate for the full duration of a lecture compared to females, students from preclinical years, and those who do not skip lectures, respectively. Lecturing techniques need to be improvised. The traditional passive mode of instruction has to be replaced with active learning and inquiry based approach to adequately utilize the time and resources spent on lectures.

The use of recorded lectures in education and the impact on lecture attendance and exam performance

NARCIS (Netherlands)

Bos, Nynke; Groeneveld, Caspar; Van Bruggen, Jan; Brand-Gruwel, Saskia

2017-01-01

Universities increasingly record lectures and make them available online for students. Though the technology to record these lectures is now solidly implemented and embed- ded in many institutions, the impact of the usage of recorded lectures on exam perfor- mance is not clear. The purpose of the

Tim Allen, one of Hollywood's top comedy actors with Rolf Landua from CERN

CERN Multimedia

Laurent Guiraud

2000-01-01

Tim Allen ('Galaxy Quest', 'For Richer and Poorer', 'The Santa Clause', Voice of 'Buzz Lightyear', in Toy Story 1 and 2), visited CERN in July 2000. He has a keen interest in modern physics. In his last book "I'm not really here" he contemplates the funny and the intriguing aspects of quantum physics in his daily life.

Lectures on the inverse scattering method

International Nuclear Information System (INIS)

Zakharov, V.E.

1983-06-01

In a series of six lectures an elementary introduction to the theory of inverse scattering is given. The first four lectures contain a detailed theory of solitons in the framework of the KdV equation, together with the inverse scattering theory of the one-dimensional Schroedinger equation. In the fifth lecture the dressing method is described, while the sixth lecture gives a brief review of the equations soluble by the inverse scattering method. (author)

La banda sonora del programa «Rá-Tim-Bum»

OpenAIRE

Almeida Duarte, Mônica de

2005-01-01

Esta comunicación trata de los resultados parciales de la investigación vuelta para el análisis de la banda sonora del programa televisivo Rá-Tim-Bum, de TV Educativa, empresa gubernamental. Se utiliza un cuadro teórico-metodológico de análisis de los discursos aplicado a la música propuesto por Amparo Porta por medio de tres niveles de aproximación: verosimilitud referencial (las calidades sonoras), poética (tratamiento de frases y de finalización) y tópica (ideologia difundida). El...

Highest recognition of Prof. N. Koga and further activities of Czech thermal analysis

Czech Academy of Sciences Publication Activity Database

Šesták, Jaroslav

2013-01-01

Roč. 573, Dec (2013), s. 158-161 ISSN 0040-6031 Grant - others:ZČP(CZ) ED2.1.00/03.0088 Institutional support: RVO:68378271 Keywords : prof. Koga * thermal analysis * thermodynamics * books * conferences Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.105, year: 2013

PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

International Nuclear Information System (INIS)

Kong, Y; Zhang, J; Claxton, D F; Ehmann, W C; Rybka, W B; Zhu, L; Zeng, H; Schell, T D; Zheng, H

2015-01-01

Prognosis of leukemia relapse post allogeneic stem cell transplantation (alloSCT) is poor and effective new treatments are urgently needed. T cells are pivotal in eradicating leukemia through a graft versus leukemia (GVL) effect and leukemia relapse is considered a failure of GVL. T-cell exhaustion is a state of T-cell dysfunction mediated by inhibitory molecules including programmed cell death protein 1 (PD-1) and T-cell immunoglobulin domain and mucin domain 3 (TIM-3). To evaluate whether T-cell exhaustion and inhibitory pathways are involved in leukemia relapse post alloSCT, we performed phenotypic and functional studies on T cells from peripheral blood of acute myeloid leukemia patients receiving alloSCT. Here we report that PD-1 hi TIM-3 + cells are strongly associated with leukemia relapse post transplantation. Consistent with exhaustion, PD-1 hi TIM-3 + T cells are functionally deficient manifested by reduced production of interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). In addition, these cells demonstrate a phenotype consistent with exhausted antigen-experienced T cells by losing T N and T EMRA subsets. Importantly, increase of PD-1 hi TIM-3 + cells occurs before clinical diagnosis of leukemia relapse, suggesting their predictive value. Results of our study provide an early diagnostic approach and a therapeutic target for leukemia relapse post transplantation

PROF DR FELIX V. lATEGAN: Die Boer se Roer. Die Groot ...

African Journals Online (AJOL)

PROF DR FELIX V. lATEGAN: Die Boer se. Roer. Die Groot Geweerboek van Suid-. Afrika. Tafelberg. Uitgewers. Kaapstad, pp. 209, bibliografie, register. Sonder die Boer en sy roer is die geskiede:lis van ons land feitlik ondenkbc:wr en dit is clan ook vo/kome juis gesien dat die skrywer van hierdie baanbrekerswerk die ...

PROF. ULRICH GERHARD LAUTS (1787— 1865). In sy studie „De ...

African Journals Online (AJOL)

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In sy studie „De beteekenis van 1813 voor Nederlands geestelijke beschaving"') het die .... af te lê. Daarna het hulle hul eed nog weer bevestig om trou te bly aan ..... L. 'n ver dedigende skrywe aan die Minister gestuur na aanleiding van 'n twis met die militêre geneesheer („Rijksarchief," Dept. van Marine. Prof. U. G..

New Fellows and Honorary Fellow

Indian Academy of Sciences (India)

... Public Lectures · Lecture Workshops · Refresher Courses · Symposia. Home; Fellowship. Fellow Profile. Elected: 1985 Honorary. Cotton, Prof. Frank Albert. Date of birth: 9 April 1930. Date of death: 20 February 2007. Last known address: Department of Chemistry, Texas A & M University, College Station, TX 77843, U.S.A..

Special Issues | Proceedings – Mathematical Sciences | Journals ...

Indian Academy of Sciences (India)

Academy Public Lecture and INSA–Leopoldina Lecture by Prof. Jörg Hacker, President, German Academy of Sciences Leopoldina. 4 December, 2017, 4 PM Faculty Hall, Indian Institute. Associates – 2017. Posted on 30 August 2017. Click here to see the list · 83rd Annual Meeting. Posted on 01 December 2017.

conf | Indian Academy of Sciences

Indian Academy of Sciences (India)

Academy Public Lecture and INSA–Leopoldina Lecture by Prof. Jörg Hacker, President, German Academy of Sciences Leopoldina. 4 December, 2017, 4 PM Faculty Hall, Indian Institute. Associates – 2017. Posted on 30 August 2017. Click here to see the list · 83rd Annual Meeting. Posted on 01 December 2017.

d8j-79.pdf | oct2009 | jessci | Indian Academy of Sciences

Indian Academy of Sciences (India)

Academy Public Lecture and INSA–Leopoldina Lecture by Prof. Jörg Hacker, President, German Academy of Sciences Leopoldina. 4 December, 2017, 4 PM Faculty Hall, Indian Institute. Associates – 2017. Posted on 30 August 2017. Click here to see the list · 83rd Annual Meeting. Posted on 01 December 2017.

Metallurgy department publications and lectures 1987

International Nuclear Information System (INIS)

Schroeder Pedersen, A.; Bilde-Soerensen, J.B.

1988-04-01

A presentation (including abstract) of scientific and technical publications and lectures by the staff of the Metallurgy Department during 1987 is given. The list comprises journal papers, conference papers, reports, lectures and poster presentations in the following categories: Publications, Lectures and Poster Presentations. (author)

Rudolf Mössbauer in Munich

Science.gov (United States)

Kalvius, G. M.; Kienle, P.

Mössbauer and one of the authors (PK) started in 1949 studying physics at the Technische Hochschule München (THM), which was still under reconstruction from the war damages. It offered two directions for studying physics: "Physik A" and "Physik B." I took courses in "Physik A," which meant Technical Physics; Mössbauer studied "Physik B," which was General Physics. Actually, the lectures of both directions were not too different up to the forth semester, followed by a "pre-diploma" examination, which Mössbauer passed in 1952. I as "Physik A" student had besides the various physics, chemistry, and mathematics courses, in addition lectures in Technical Electricity, Technical Mechanics, Technical Thermodynamics, and later Measurement Engineering offered by very famous professors, such as W.O. Schumann, L. Föppl, W. Nußelt, and H. Piloty. Our physics teachers were G. Joos (Experimental physics), G. Hettner (Theoretical Physics), and W. Meissner (Technical Physics); in mathematics, we enjoyed lectures by J. Lense and R. Sauer, and interesting chemistry lectures by W. Hieber. Thus we received a high-class classical education, but quantum mechanics was not a compulsory subject. Mössbauer complained about this deficiency when he realized that the effect he found was a quantum mechanical phenomenon. Quantum mechanics was offered as an optional subject by Prof. Fick and Prof. Haug. Mössbauer just missed to take these advanced lectures, although he was highly talented in mathematics and received even a tutoring position in the mathematics institute of Prof. R. Sauer, while I worked in engineering projects and had extensive industrial training.

Online Lecture Recordings and Lecture Attendance: Investigating Student Preferences in a Large First Year Psychology Course

Science.gov (United States)

Yeung, Alexandra; Raju, Sadhana; Sharma, Manjula D.

2016-01-01

While blended learning has been around for some time, the interplay between lecture recordings, lecture attendance and grades needs further examination particularly for large cohorts of over 1,000 students in 500 seat lecture theatres. This paper reports on such an investigation with a cohort of 1,450 first year psychology students' who indicated…

The Use of Recorded Lectures in Education and the Impact on Lecture Attendance and Exam Performance

Science.gov (United States)

Bos, Nynke; Groeneveld, Caspar; van Bruggen, Jan; Brand-Gruwel, Saskia

2016-01-01

Universities increasingly record lectures and make them available online for students. Though the technology to record these lectures is now solidly implemented and embedded in many institutions, the impact of the usage of recorded lectures on exam performance is not clear. The purpose of the current study is to address the use of recorded…

High affinity anti-TIM-3 and anti-KIR monoclonal antibodies cloned from healthy human individuals.

Directory of Open Access Journals (Sweden)

Stefan Ryser

Full Text Available We report here the cloning of native high affinity anti-TIM-3 and anti-KIR IgG monoclonal antibodies (mAbs from peripheral blood mononuclear cells (PBMC of healthy human donors. The cells that express these mAbs are rare, present at a frequency of less than one per 105 memory B-cells. Using our proprietary multiplexed screening and cloning technology CellSpot™ we assessed the presence of memory B-cells reactive to foreign and endogenous disease-associated antigens within the same individual. When comparing the frequencies of antigen-specific memory B-cells analyzed in over 20 screening campaigns, we found a strong correlation of the presence of anti-TIM-3 memory B-cells with memory B-cells expressing mAbs against three disease-associated antigens: (i bacterial DNABII proteins that are a marker for Gram negative and Gram positive bacterial infections, (ii hemagglutinin (HA of influenza virus and (iii the extracellular domain of anaplastic lymphoma kinase (ALK. One of the native anti-KIR mAbs has similar characteristics as lirilumab, an anti-KIR mAb derived from immunization of humanized transgenic mice that is in ongoing clinical trials. It is interesting to speculate that these native anti-TIM-3 and anti-KIR antibodies may function as natural regulatory antibodies, analogous to the pharmacological use in cancer treatment of engineered antibodies against the same targets. Further characterization studies are needed to define the mechanisms through which these native antibodies may function in healthy and disease conditions.

LITERASI MEDIA SEBAGAI STRATEGI KOMUNIKASI TIM SUKSES RELAWAN PEMENANGAN PEMILIHAN PRESIDEN JOKOWI JK DI BANDUNG

Directory of Open Access Journals (Sweden)

Annisa Senova

2016-12-01

Full Text Available Memahami kegiatan literasi media yang terjadi dalam kehidupan berorganisasi akan memberikan gambaran yang jelas tentang kemampuan mengidentifikasi, menentukan, mengorganisir, dan menggunakan media, serta menjadikan informasi sebagai bahan pertimbangan pembuatan keputusan tim sukses relawan pemenangan Presiden Joko Widodo dan Jusuf Kalla di Bandung. Oleh karena itu, penelitian ini dilakukan untuk menemukan kegiatan literasi media sebagai strategi komunikasi tim sukses relawan pemenangan pemilihan presiden Joko Widodo dan Jusuf Kalla. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan pendekatan studi kasus. Penelitian ini menggunakan teknik pengumpulan data berupa wawancara mendalam, observasi, dan studi dokumentasi. Teknik pemeriksaan keabsahan data yang digunakan dalam penelitian ini adalah dengan triangulasi data sumber. Media sosial menjadi media utama dalam proses penyampaian pesan kepada khalayak di kota Bandung. Terdapat beberapa jenis media sosial yang akan digunakan secara rutin dalam proses tersebut, yaitu Twitter, Facebook, Instagram, dan Youtube. Namun, timses relawan media sosial hanya fokus kepada dua jenis media sosial yang dianggap dapat mempengaruhi pandangan publik. Twiter dan Instagram dianggap mampu menjadi jejaring sosial yang efektif dalam proses penyampaian pesan politik pemilu 2014. Penyampaian informasi oleh timses relawan media sosial kepada masyarakat melalui Twitter dan Instagram dianggap sangat efektif dan tepat. Konten-konten yang disediakan oleh akun Twitter sangat mudah untuk diakses oleh semua kalangan. Penelitian tantang proses literasi media tim sukses relawan pemenangan presiden Jokowi-Jk ini dapat menambah masukan bagi ilmu komunikasi, terutama dalam bidang literasi media, bahwa saat ini keberadaan media dapat menjadi sebuah strategi komunikasi yang cukup efektif.   DOI: 10.24198/jkk.vol4n2.3

Explicit constructivism: a missing link in ineffective lectures?

Science.gov (United States)

Prakash, E S

2010-06-01

This study tested the possibility that interactive lectures explicitly based on activating learners' prior knowledge and driven by a series of logical questions might enhance the effectiveness of lectures. A class of 54 students doing the respiratory system course in the second year of the Bachelor of Medicine and Bachelor of Surgery program in my university was randomized to two groups to receive one of two types of lectures, "typical" lectures (n = 28, 18 women and 10 men) or "constructivist" lectures (n = 26, 19 women and 7 men), on the same topic: the regulation of respiration. Student pretest scores in the two groups were comparable (P > 0.1). Students that received the constructivist lectures did much better in the posttest conducted immediately after the lectures (6.8 +/- 3.4 for constructivist lectures vs. 4.2 +/- 2.3 for typical lectures, means +/- SD, P = 0.004). Although both types of lectures were well received, students that received the constructivist lectures appeared to have been more satisfied with their learning experience. However, on a posttest conducted 4 mo later, scores obtained by students in the two groups were not any different (6.9 +/- 3 for constructivist lectures vs. 6.9 +/- 3.7 for typical lectures, P = 0.94). This study adds to the increasing body of evidence that there is a case for the use of interactive lectures that make the construction of knowledge and understanding explicit, easy, and enjoyable to learners.

PREFACE: XXIX International Conference on Photonic, Electronic, and Atomic Collisions (ICPEAC2015)

Science.gov (United States)

Díaz, C.; Rabadán, I.; García, G.; Méndez, L.; Martín, F.

2015-09-01

The 29th International Conference on Photonic, Electronic and Atomic Collisions (XXIX ICPEAC) was held at the Palacio de Congresos ''El Greco'', Toledo, Spain, on 22-28 July, 2015, and was organized by the Universidad Autónoma de Madrid (UAM) and the Consejo Superior de Investigaciones Científicas (CSIC). ICPEAC is held biannually and is one of the most important international conferences on atomic and molecular physics. The topic of the conference covers the recent progresses in photonic, electronic, and atomic collisions with matter. With a history back to 1958, ICPEAC came to Spain in 2015 for the very first time. UAM and CSIC had been preparing the conference for six years, ever since the ICPEAC International General Committee made the decision to hold the XXIX ICPEAC in Toledo. The conference gathered 670 participants from 52 countries and attracted 854 contributed papers for presentation in poster sessions. Among the latter, 754 are presented in issues 2-12 of this volume of the Journal of Physics Conference Series. In addition, five plenary lectures, including the opening one by the Nobel laureate Prof. Ahmed H. Zewail and the lectures by Prof. Maciej Lewenstein, Prof. Paul Scheier, Prof. Philip H. Bucksbaum, and Prof. Stephen J. Buckman, 62 progress reports and 26 special reports were presented following the decision of the ICPEAC International General Committee. Detailed write-ups of most of the latter are presented in issue 1 of this volume, constituting a comprehensive tangible record of the meeting. On the occasion of the International Year of Light (IYL2015) and with the support of the Fundación Española para la Ciencia y la Tecnología (FECYT), the program was completed with two public lectures delivered by the Nobel laureate Prof. Serge Haroche and the Príncipe de Asturias laureate Prof. Pedro M. Echenique on, respectively, ''Fifty years of laser revolutions in physics'rquot; and ''The sublime usefulness of useless science''. Also a

Flipped classroom or an active lecture?

Science.gov (United States)

Pickering, James D; Roberts, David J H

2018-01-01

Recent changes in anatomy education have seen the introduction of flipped classrooms as a replacement to the traditional didactic lecture. This approach utilizes the increasing availability of digital technology to create learning resources that can be accessed prior to attending class, with face-to-face sessions then becoming more student-centered via discussion, collaborative learning, and problem-solving activities. Although this approach may appear intuitive, this viewpoint commentary presents a counter opinion and highlights a simple alternative that utilizes evidence-based active learning approaches as part of the traditional lecture. The active lecture takes the traditional lecture, and (1) ensures the lecture content is relevant and has clear objectives, (2) contains lecture material that is designed according to the latest evidence-base, (3) complements it with additional supplementary material, (4) creates space to check prior understanding and knowledge levels, and (5) utilizes suitable technology to facilitate continual engagement and interaction. Clin. Anat. 31:118-121, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Improving Lecture Quality through Training in Public Speaking

Science.gov (United States)

Mowbray, Robert; Perry, Laura B.

2015-01-01

Lecturing is a common instructional format but poor lecturing skills can detract from students' learning experiences and outcomes. As lecturing is essentially a form of public communication, training in public speaking may improve lecture quality. Twelve university lecturers in Malaysia participated in a six-week public speaking skills training…

Water Technology Lecture 1: Introducing Water Technology

OpenAIRE

Gray, Nicholas Frederick

2017-01-01

This is a full set of PowerPoint lectures for a course in Water Technology currently given at Trinity College, University of Dublin by professor N.F. Gray. The lectures cover all aspects of water and wastewater treatment and are available for use to lecturers or those interested in the subject. The lecture series is to be used in conjunction with the new textbook ?Water Science and Technology? (4th edition) published by CRC Press in 2017. Lecture 1 is an introduction to the water indust...

Campus lecture marks Conflict Resolution Day Oct. 21

OpenAIRE

Owczarski, Mark

2010-01-01

Virginia Tech's Conflict Resolution Program will sponsor a video conference presentation by Craig Runde and Tim Flanagan, co-authors of three books on conflict in the workplace, as the university marks International Conflict Resolution Day Thursday, Oct. 21.

Co-ordinated Classroom Lectures.

Science.gov (United States)

Harmon, Darell Boyd

From a series of lectures, a selection of eight are oriented principally toward the biologically developing child, and the physiological operations in visual process. The numbered lectures are--(1) The Coordinated Classroom, its Philosophy and Principles, (2) An Outline of a Biological Point of View, (3) The Evolution of Structure--despite man's…

Statins reduce the expressions of Tim-3 on NK cells and NKT cells in atherosclerosis.

Science.gov (United States)

Zhang, Na; Zhang, Min; Liu, Ru-Tao; Zhang, Peng; Yang, Chun-Lin; Yue, Long-Tao; Li, Heng; Li, Yong-Kang; Duan, Rui-Sheng

2018-02-15

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have an immuno-regulatory effect in addition to lowing-lipids. Accumulated evidence showed that the expressions of T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) on natural killer (NK) cells increased in atherosclerotic patients and animal models. In this study, 14 patients treated with rosuvastatin and 12 patients with atorvastatin for more than 3 months were included and 20 patients without statins treatment as control. Both statins treatment reduced the expressions of Tim-3 on NK cells and their subtypes, natural killer T (NKT) cells and CD3 + T cells, and increased the proportions of NKT cells among peripheral blood mononuclear cells, accompanied by the decreased levels of total cholesterol, low density lipoprotein, and increased ratios of high density lipoprotein to cholesterol. These may contribute to the functions of statins in the treatment of atherosclerosis. Copyright © 2017 Elsevier B.V. All rights reserved.

Effect of difference between group constants processed by codes TIMS and ETOX on integral quantities

International Nuclear Information System (INIS)

Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi.

1978-06-01

Group constants of 235 U, 238 U, 239 Pu, 240 Pu and 241 Pu have been produced with the processing code TIMS using the evaluated nuclear data of JENDL-1. The temperature and composition dependent self-shielding factors have been calculated for the two cases with and without considering mutual interference resonant nuclei. By using the group constants set produced by the TIMS code, the integral quantities, i.e. multiplication factor, Na-void reactivity effect and Doppler reactivity effect, are calculated and compared with those calculated with the use of the cross sections set produced by the ETOX code to evaluate accuracy of the approximate calculation method in ETOX. There is much difference in self-shielding factor in each energy group between the two codes. For the fast reactor assemblies under study, however, the integral quantities calculated with these two sets are in good agreement with each other, because of eventual cancelation of errors. (auth.)

Video Lecture Capture Technology Helps Students Study without Affecting Attendance in Large Microbiology Lecture Courses?

OpenAIRE

McLean, Jennifer L.; Suchman, Erica L.

2016-01-01

Recording lectures using video lecture capture software and making them available for students to watch anytime, from anywhere, has become a common practice in many universities across many disciplines. The software has become increasingly easy to use and is commonly provided and maintained by higher education institutions. Several studies have reported that students use lecture capture to enhance their learning and study for assessments, as well as to catch up on material they miss when they...

Electronic voting to encourage interactive lectures: a randomised trial

Science.gov (United States)

2007-01-01

Background Electronic Voting Systems have been used for education in a variety of disciplines. Outcomes from these studies have been mixed. Because results from these studies have been mixed, we examined whether an EVS system could enhance a lecture's effect on educational outcomes. Methods A cohort of 127 Year 5 medical students at the University of Adelaide was stratified by gender, residency status and academic record then randomised into 2 groups of 64 and 63 students. Each group received consecutive 40-minute lectures on two clinical topics. One group received the EVS for both topics. The other group received traditional teaching only. Evaluation was undertaken with two, 15-question multiple-choice questionnaires (MCQ) assessing knowledge and problem solving and undertaken as a written paper immediately before and after the lectures and repeated online 8–12 weeks later. Standardised institutional student questionnaires were completed for each lecture and independent observers assessed student behaviour during the lectures. Lecturer's opinions were assessed by a questionnaire developed for this study. Results Two-thirds of students randomised to EVS and 59% of students randomised to traditional lectures attended. One-half of the students in the EVS group and 41% in the traditional group completed all questionnaires. There was no difference in MCQ scores between EVS and traditional lectures (p = 0.785). The cervical cancer lectures showed higher student ranking in favour of EVS in all parameters. The breast cancer lectures showed higher ranking in favour of traditional lectures in 5 of 7 parameters (p lecturer-students interactions were increased in the EVS lecture for one lecturer and reduced for the other. Both lecturers felt that the EVS lectures were difficult to prepare, that they were able to keep to time in the traditional lectures, that the educational value of both lecture styles was similar, and that they were neutral-to-slightly favourably disposed

The 1979 Bernard Gregory lectures

International Nuclear Information System (INIS)

Weisskopf, V.F.

1980-02-01

This volume contains the texts of the lectures given by Professor V.F. Weisskopf at CERN and in Paris in the autumn of 1979, as the first Gregory lecturer. The titles of the three different texts are 'Growing up with Field Theory', 'Recent Trends in Particle Physics' and 'L'Art et la Science'. While the latter lecture was given in French, an English text here follows the French one. The volume starts with a short biographical note about Bernard Gregory. (orig.)

Summer Student Lecture Programme

CERN Multimedia

2004-01-01

Main Auditorium, bldg. 500 DATE TIME LECTURER TITLE Monday 2 August 09:15 - 10:00 P. Wells (CERN) The Higgs Saga at LEP 10:15 - 11:00 G. Cowan (Univ. of London) Introduction to Statistics (2/3) 11:15 - 12:00 G. Cowan (Univ. of London) Introduction to Statistics (3/3) DATE TIME LECTURER TITLE Tuesday 3 August 09:15 - 10:00 P. Sphicas (CERN) Trigger and Data Acquisition Systems (1/2) 10:15 - 11:00 R. Jacobsen (LBLN) From Raw Data to Physics Results (1/2) 11:15 - 12:00 R. Jacobsen (LBLN) G. Cowan (University of London) Discussion Session DATE TIME LECTURER TITLE Wednesday 4 August 09:15 - 10:00 P. Sphicas (CERN) Trigger and Data Acquisition Systems (2/2) 10:15 - 11:00 R. Jacobsen (LBLN) From Raw Data to Physics Results (2/2) 11:15 - 12:00 N. Palanque-Delabrouille (CEA) Astroparticle Physics (1/3) DATE TIME LECTURER TITLE Thursday 5 August 09:15 - 10:00 N. Palanque-Delabrouille (CEA) Astroparticle Physics (2/3) 10:15 - 11:00 N. Palanque-Delabrouille (CEA) A...

TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens

Directory of Open Access Journals (Sweden)

Yoshihisa Hiraishi

2016-10-01

Conclusions: Our findings indicate that, in mice, TIM-3 is not essential for development of HDM-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM-induced chronic allergic airway inflammation.

Assessment of vocal intensity in lecturers depending on acoustic properties of lecture rooms

Directory of Open Access Journals (Sweden)

Witold Mikulski

2015-08-01

Full Text Available Background: Lombard’s effect increases the level of vocal intensity in the environment, in which noise occurs. This article presents the results of the author’s own study of vocal intensity level and A-weighted sound pressure level of background noise during normal lectures. The aim of the study was to define whether above-mentioned parameters depend on acoustic properties of rooms (classrooms or lecture rooms and to define how many lectors speak with raised voice. Material and Methods: The study was performed in a group of 50 teachers and lecturers in 10 classrooms with cubature of 160–430 m3 and reverberation time of 0.37–1.3 s (group A consisted of 3 rooms which fulfilled, group B consisted of 3 rooms which almost fulfilled and group C consisted of 4 rooms which did not fulfill criteria based on reverberation time (maximum permissible value is 0.6–0.8 s according to PN-B-02151-4:2015. Criteria of raising voice were based on vocal intensity level (maximum value: 65 dB according to EN ISO 9921:2003. The values of above-mentioned parameters were determined from modes of A-weighted sound pressure level distributions during lectures. Results: Great differentiation of vocal intensity level between lectors was found. In classrooms of group A lectors were not using raised voice, in group B – 21%, and in group C – 60% of lectors were using raised voice. Conclusions: It was observed that acoustic properties of classrooms (defined by reverberation time exert their effect on lecturer’s vocal intensity level (i.e., raising voice, which may contribute to the increased risk of vocal tract illnesses. The occurrence of Lombard’s effect in groups of teachers and lecturers, conducting lectures in rooms, was evidenced. Med Pr 2015;66(4:487–496

Public Lecture: Human Space Exploration

CERN Multimedia

CERN. Geneva

2015-01-01

Should you wish to attend to this lecture only (and not the full colloquium), please register here: https://indico.cern.ch/event/386996/registration/ Participants to the full colloquium are automatically registered to the public lectures.

ACADEMIC TRAINING LECTURE

CERN Multimedia

Academic Training; Tel. 73127

2001-01-01

5, 6, 7, 8 and 9 March REGULAR LECTURE PROGRAMME From 11:00 hrs - Main Auditorium bldg. 500 Tracking at the LHC K. Safarik / CERN-EP The lecture will start with a short history of particle tracking in high-energy physics. Then we will concentrate on tracking in the LHC experiments. We will discuss various tracking devices proposed for these experiments, dividing them into two large groups: solid state detectors and gas detectors. Their characteristics, as well as their behaviour in different external conditions (i.e. magnetic field, radiation) will be compared. Furthermore, we will turn to the question: how to design a tracker using these various technologies, what are the essential parameters to be taken into account and we will apply these considerations to the proposed the LHC detectors. The last part of the lecture will be devoted to tracking software. We will mention simulation and concentrate on track finding and reconstruction, reviewing different algorithms prototyped for the LHC experiments. We will ...

Prof.Dr. Ahmed Yüksel Özemre’nin Tasavvufî Görüşleri

OpenAIRE

KALKAN, Bilgihan

2015-01-01

Prof. Dr. Ahmed Yüksel Özemre(1935-2008), Türkiye’nin ilk atom mühendisiolmasının yanı sıra Türkiye Atom Enerjisi (TAE) Kurumundaki görevidolayısı ile ülkemizin tanınmış ilim adamlarındandır. Bu makalede Prof. Dr. AhmedYüksel Özemre’nin daha az bilinen ve çocukluk çağlarında tasavvufî muhitlerile yakın temas halinde bulunması ile başlayan ve zaman içerisinde yalnızcaentelektüel bir uğraş olmanın ötesine geçerek, yaşam şekline dönüşen tasavvufîhayatı ve genel hatları ile İslâm tasavvufu hakkın...

A Survey of First-Year Biology Student Opinions Regarding Live Lectures and Recorded Lectures as Learning Tools

Science.gov (United States)

Simcock, D. C.; Chua, W. H.; Hekman, M.; Levin, M. T.; Brown, S.

2017-01-01

A cohort of first-year biology students was surveyed regarding their opinions and viewing habits for live and recorded lectures. Most respondents (87%) attended live lectures as a rule (attenders), with 66% attending more than two-thirds of the lectures. In contrast, only 52% accessed recordings and only 13% viewed more than two-thirds of the…

IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast cancer

Energy Technology Data Exchange (ETDEWEB)

Heon, Elise K. [University of Maryland Medical Center, Baltimore, MD 21201 (United States); Wulan, Hasi [Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing, 100853 (China); Macdonald, Loch P.; Malek, Adel O.; Braunstein, Glenn H.; Eaves, Connie G.; Schattner, Mark D. [Brown University, Providence, RI 02912 (United States); Allen, Peter M.; Alexander, Michael O.; Hawkins, Cynthia A.; McGovern, Dermot W.; Freeman, Richard L. [University of Wisconsin, Madison, WI 53706 (United States); Amir, Eitan P.; Huse, Jason D. [University of Illinois, Chicago, IL 60607 (United States); Zaltzman, Jeffrey S.; Kauff, Noah P.; Meyers, Paul G. [University of Texas, Austin, TX 78712 (United States); Gleason, Michelle H., E-mail: GleasonM@cblabs.org [University of Texas, Austin, TX 78712 (United States); Overholtzer, Michael G., E-mail: OverholtzerM@cblabs.org [University of Texas, Austin, TX 78712 (United States); Wiseman, Sam S. [Ohio State University, Columbus, OH 43210 (United States); and others

2015-08-14

IL-15 has pivotal roles in the control of CD8{sup +} memory T cells and has been investigated as a therapeutic option in cancer therapy. Although IL-15 and IL-2 share many functions together, including the stimulation of CD8 T cell proliferation and IFN-γ production, the different in vivo roles of IL-15 and IL-2 have been increasingly recognized. Here, we explored the different effects of IL-15 and IL-2 on tumor-infiltrating (TI) T cells from resected breast tumors. We found that neither IL-2 nor IL-15 induced intratumoral CD8 T cell proliferation by itself, but after CD3/CD28-stimulation, IL-15 induced significantly higher proliferation than IL-2 during early time points, at day 2, day 3 and day 6. However, the IL-15-induced proliferation leveled off at day 9 and day 12, whereas IL-2 induced lower but progressive proliferation at each time point. Furthermore, IL-15 caused an early and robust increase of IFN-γ in the supernatant of TI cell cultures, which diminished at later time points, while the IL-2-induced IFN-γ production remained constant over time. In addition, the IL-15-costimulated CD8 T cells presented higher frequencies of apoptotic cells. The diminishing IL-15-induced response was possibly due to regulatory and/or exhaustion mechanisms. We did not observe increased IL-10 or PD-1 upregulation, but we have found an increase of Tim-3 upregulation on IL-15-, but not IL-2-stimulated cells. Blocking Tim-3 function using anti-Tim-3 antibodies resulted in increased IL-15-induced proliferation and IFN-γ production for a prolonged period of time, whereas adding Tim-3 ligand galectin 9 led to reduced proliferation and IFN-γ production. Our results suggest that IL-15 in combination of Tim-3 blocking antibodies could potentially act as an IL-2 alternative in tumor CD8 T cell expansion in vitro, a crucial step in adoptive T cell therapy. - Highlights: • We explored the effects of IL-15 and IL-2 on tumor-infiltrating (TI) T cells of breast cancer. • IL-15

PENGARUH GAYA KEPEMIMPINAN TRANSFORMASIONAL PADA KOMITMEN, KEPUASAN KERJA DAN NIAT PINDAH KERJA DENGAN PERAN MEDIASI KEADILAN DAN KEPERCAYAAN DI RSO PROF. DR. R. SOEHARSO SURAKARTA

Directory of Open Access Journals (Sweden)

Paryanto Paryanto

2017-04-01

Full Text Available Improving the quality of hospital services can not be separated from the role of the various disciplines of health workers in hospitals, including nurses, because most hospital services are nursing services. The purpose of this study was to analyze the effect of transformational leadership style on commitment, job satisfaction and nurses’ intent to move RSO Prof. Dr. R. Soeharso Surakarta with the mediating role of justice and trust. The study also is associative causal research that seek causal influence of the variables to be studied. This research was conducted and involved nurses Orthopaedic Hospital Prof. Dr. R. Soeharso Surakarta. The number of samples of this study were 124 nurses Orthopaedic Hospital Orthopedics Prof. Dr. R. Soeharso Surakarta. The results showed that transformational leadership style influence on commitment, job satisfaction and nurses’ intent to move RSO Prof. Dr. R. Soeharso Surakarta with the mediating role of justice and trust.

Film documentaire, lecture documentarisante

Directory of Open Access Journals (Sweden)

Roger Odin

2012-06-01

Full Text Available Réfléchir sur la relation entre le cinéma et la réalité n’est pas, bien sûr, tenter de distinguer l’espace du documentaire de celui de la fiction, au point que l’opposition avec le film de fiction est devenu le critère de définition privilégié du film documentaire. Prenant acte l’existence, dans le espace de la lecture des films, d’une lecture documentaire ou, plus exactement, d’une lecture documentarisante, nous pensons qu’il y a un ensemble de films que s’affiche comme documentaire (tout le problème est précisément étudier comment s’effetue cet affichage.

Are radiography lecturers, leaders?

International Nuclear Information System (INIS)

Hendry, Julie Anne

2013-01-01

This review article aims to explore the concept of radiography lecturers acting as leaders to their student followers. Through a brief review of the literature, a definition of leadership is suggested and some leadership theories explored. The path-goal theory, leader–member exchange theory and the contemporary theory of transformational leadership are examined more closely. Links between lecturer-leader behaviour and student motivation and learning are tentatively suggested with transformational leadership appearing to offer the optimal leadership style for lecturers to adopt. The paucity of literature relating directly to radiography is acknowledged and areas for further research are suggested. The article concludes with some of the author's practical ideas for incorporating transformational leadership styles and behaviours into radiography education today

Albert Einstein memorial lectures

CERN Document Server

Mechoulam, Raphael; The Israel Academy for Sciences and Humanities

2012-01-01

This volume consists of a selection of the Albert Einstein Memorial Lectures presented annually at the Israel Academy of Sciences and Humanities. Delivered by eminent scientists and scholars, including Nobel laureates, they cover a broad spectrum of subjects in physics, chemistry, life science, mathematics, historiography and social issues. This distinguished memorial lecture series was inaugurated by the Israel Academy of Sciences and Humanities following an international symposium held in Jerusalem in March 1979 to commemorate the centenary of Albert Einstein's birth. Considering that Einstein's interests, activities and influence were not restricted to theoretical physics but spanned broad fields affecting society and the welfare of humankind, it was felt that these memorial lectures should be addressed to scientists, scholars and erudite laypersons rather than to physicists alone.

Approaches to vegetation mapping and ecophysiological hypothesis testing using combined information from TIMS, AVIRIS, and AIRSAR

Science.gov (United States)

Oren, R.; Vane, G.; Zimmermann, R.; Carrere, V.; Realmuto, V.; Zebker, Howard A.; Schoeneberger, P.; Schoeneberger, M.

1991-01-01

The Tropical Rainforest Ecology Experiment (TREE) had two primary objectives: (1) to design a method for mapping vegetation in tropical regions using remote sensing and determine whether the result improves on available vegetation maps; and (2) to test a specific hypothesis on plant/water relations. Both objectives were thought achievable with the combined information from the Thermal Infrared Multispectral Scanner (TIMS), Airborne Visible/Infrared Imaging Spectrometer (AVIRIS), and Airborne Synthetic Aperture Radar (AIRSAR). Implicitly, two additional objectives were: (1) to ascertain that the range within each variable potentially measurable with the three instruments is large enough in the site, relative to the sensitivity of the instruments, so that differences between ecological groups may be detectable; and (2) to determine the ability of the three systems to quantify different variables and sensitivities. We found that the ranges in values of foliar nitrogen concentration, water availability, stand structure and species composition, and plant/water relations were large, even within the upland broadleaf vegetation type. The range was larger when other vegetation types were considered. Unfortunately, cloud cover and navigation errors compromised the utility of the TIMS and AVIRIS data. Nevertheless, the AIRSAR data alone appear to have improved on the available vegetation map for the study area. An example from an area converted to a farm is given to demonstrate how the combined information from AIRSAR, TIMS, and AVIRIS can uniquely identify distinct classes of land use. The example alludes to the potential utility of the three instruments for identifying vegetation at an ecological scale finer than vegetation types.

Lecturer on tour!

Science.gov (United States)

1998-11-01

Readers may recall the interview with Professor Peter Kalmus which appeared in the July issue of Physics Education and which indicated his latest role of lecturer for the 1998-9 Institute of Physics Schools and Colleges Lecture series. This year's lecture is entitled `Particles and the universe' and the tour was due to begin in St Andrews, Scotland, late in September. Professor Kalmus will be looking at various aspects of particle physics, quantum physics and relativity, and discussing how they reveal the secrets of the beginning of our universe. His own experience of working at CERN, the European centre for particle physics in Switzerland, as well as at other international research facilities will provide a unique insight into activity in one of the most exciting areas of physics. The talks are aimed at the 16-19 age group but members of the public are also welcome to attend. They will act as an opportunity to gain a sneak preview of the dynamic new topics that will soon feature in the A-level syllabus arising from the Institute's 16-19 project. Further details of attendance are available from the local organizers, a list of whom may be obtained from Catherine Wilson in the Education Department at the Institute of Physics, 76 Portland Place, London W1N 3DH (tel: 0171 470 4800, fax: 0171 470 4848). The published schedule (as of September) for the lecture series consists of the following: Dates

Characteristics of the Institute of Technology 'Prof. Jorge A. Sabato'

International Nuclear Information System (INIS)

Galvele, Jose R.

2001-01-01

A historical survey is made of the educational and training activities in metallurgy and material sciences carried out by the CNEA since 1962, that were the origin of the 'Prof. Jorge A. Sabato' Institute. Today the Institute, created by the CNEA in association with the National University of General San Martin, is preparing Engineers in Material Sciences and Masters and Ph. D. in Material Sciences and Technology (Mention in Physics and Material). The curricula of the studies are described in detail. The Information Center annexed to the Institute is also described

The Filmmaker as Humanist: An Interview with Tim Robbins on the Making of "Cradle Will Rock".

Science.gov (United States)

Mason, Terrence C.

2000-01-01

Presents an interview with Tim Robbins that focuses on the making of the film "Cradle Will Rock." Robbins offers his perspectives on issues such as the power of art to convey important social messages and sources of violence in schools. Includes resources for teachers. (CMK)

Students’ opinions about modern lecture: development path

Directory of Open Access Journals (Sweden)

Tatyana A. Astashova

2017-01-01

Full Text Available As an objective of the research, the author set the task of identifying students’ opinion and opinion of lecturers about the purpose of the lectures at the university, about the role of the lecturer and preferred form of lectures. As a result of the research, it was necessary to answer the following important questions: What are the objectives of the lecture and the role of the lecturer? Which lectures are more preferable: traditional or interactive? What do lecturers expect from the lecture, do they consider it an advantage or an unnecessary educational activity?The materials were developed for the survey (questionnaire to conduct the research and analyze the results obtained. The students were surveyed before training and after completion of the semester. The study involved 200 students of all areas of Mechanics and Technology Faculty of Novosibirsk State Technical University. Statistical analysis was used for the analysis of the results.As a result, the experiment revealed nonconformity of opinions of students about the purpose of the lecture and the role of a lecturer before the training and after the end of the semester. Lectures, according to students, should help to implement all kinds of practical and independent assignments.Educational standards imply a reduction in the hours of classroom training and an increase in independent work, and the majority of students are not ready (do not want to to study the materials on the topics of discipline completely independently or partially.It revealed a contradiction in opinion, what form of organization of the lecture classes is more interesting to students, which can increase the motivation of the visit and work on the lectures.The technology of designing the educational process in the conditions of the mixed training is proposed, applying the technological map.The technological map is presented in the form of stages of designing the educational process, including recommendations on the use of

Dr Luigi Orlando, Dr Sergio Ceccuzzi, Dr. Armando Sbrana, Europa Metalli, Italy, Dr Albert Scherger, Member of KM Europa Metal AG, Osnabr ck, Germany, Prof. Filippo Menzinger, Scientific Attaché, Permanent Mission of Italy in Geneva

CERN Multimedia

Patrice Loïez

2001-01-01

Photo 01: Dr Lyn Evans and Dr Luigi Orlando Photo 04: L. to r.: Dr Lyn Evans, Dr Luigi Orlando, Prof. Luciano Maiani and Prof. Filippo Menzinger Photo 06: L. to r.: Prof. Philippo Menzinger, Dr Armando Sbrana, Prof. Luciano Maiani, Dr Albert Scherger, Dr Lyn Evans, Dr Luigi Orlando, Dr Sergio Ceccuzzi, visiting the LHC superconducting magnet test hall, SM18

Anthropocentric Video Segmentation for Lecture Webcasts

Directory of Open Access Journals (Sweden)

Rojas Raul

2007-01-01

Full Text Available Abstract Many lecture recording and presentation systems transmit slides or chalkboard content along with a small video of the instructor. As a result, two areas of the screen are competing for the viewer's attention, causing the widely known split-attention effect. Face and body gestures, such as pointing, do not appear in the context of the slides or the board. To eliminate this problem, this article proposes to extract the lecturer from the video stream and paste his or her image onto the board or slide image. As a result, the lecturer acting in front of the board or slides becomes the center of attention. The entire lecture presentation becomes more human-centered. This article presents both an analysis of the underlying psychological problems and an explanation of signal processing techniques that are applied in a concrete system. The presented algorithm is able to extract and overlay the lecturer online and in real time at full video resolution.

Anthropocentric Video Segmentation for Lecture Webcasts

Directory of Open Access Journals (Sweden)

Raul Rojas

2008-03-01

Full Text Available Many lecture recording and presentation systems transmit slides or chalkboard content along with a small video of the instructor. As a result, two areas of the screen are competing for the viewer's attention, causing the widely known split-attention effect. Face and body gestures, such as pointing, do not appear in the context of the slides or the board. To eliminate this problem, this article proposes to extract the lecturer from the video stream and paste his or her image onto the board or slide image. As a result, the lecturer acting in front of the board or slides becomes the center of attention. The entire lecture presentation becomes more human-centered. This article presents both an analysis of the underlying psychological problems and an explanation of signal processing techniques that are applied in a concrete system. The presented algorithm is able to extract and overlay the lecturer online and in real time at full video resolution.

El De imaginibus caelestibus de Ibn al-Ḥātim

OpenAIRE

Oliveras, Marc

2009-01-01

En 1987 K. Lippincott y D. Pingree publicaron una primera edición latina junto a una traducción inglesa del tratado bilingüe árabo-latino del s. XV De imaginibus caelestibus, escrito originariamente por el andalusí Ibn al-Ḥātim en el s. X. El trabajo que se presenta aquí pretende completar al precedente con una edición del texto árabe, su traducción al español y añadir algunas interpretaciones a las posibles fuentes de la imaginería talismánica. En este breve tratado de astromagia, Ibn al-Ḥāt...

Three lectures on Newton's laws

OpenAIRE

Kokarev, Sergey S.

2009-01-01

Three small lectures are devoted to three Newton's laws, lying in the foundation of classical mechanics. These laws are analyzed from the viewpoint of our contemporary knowledge about space, time and physical interactions. The lectures were delivered for students of YarGU in RSEC "Logos".

Envisioning the Transformative Role of IT in Lectures

Directory of Open Access Journals (Sweden)

Telmo Zarraonandia

2013-02-01

Full Text Available One of the most widely used methods for teaching is the lecture. During the last few decades lecturers and students have taken advantage of the progressive introduction of new technology for supporting these lectures. As this trend is very likely to continue, in this paper we will try to anticipate some possible technology enriched future lecture scenarios. We also present ALFs, a system which aims to improve the communication between participants in a lecture making use of augmented reality techniques.

Diversity dynamics operating between students lecturers and management in a historically Black university: The lecturers perspective

Directory of Open Access Journals (Sweden)

Michelle S. May

2012-03-01

Research purpose: The purpose of the research was to describe the experiences of nine lecturers in a particular HBU. This was undertaken to analyse and interpret the conscious and unconscious diversity dynamics operating in the relationship between the students, lecturers and management, from the lecturers’ perspective. Motivation for the study: The researcher was interested in the nature of the diversity dynamics operating in the relationship between students, lecturers and management in an HBU, as a platform towards understanding diversity dynamics in educational institutions and South African organisations. Research design, approach and method: Qualitative and descriptive research approaches were used. Hermeneutic phenomenology, using the systems psychodynamic perspective, allowed for the description and interpretation of diversity dynamics operating in the relationship between the students, lecturers and management. The data were obtained through in-depth interviews with nine lecturers. Thematic analysis resulted in two broad themes for which a discussion was provided and a research hypothesis formulated. Main findings: Two broad themes manifested, firstly diversity characteristics and secondly struggle skills entrenching the Black and White divide. Practical/managerial implications: The research highlighted the importance of understanding the diversity dynamics operating in the relationship between students, lecturers and management. This was in order to develop our understanding of diversity dynamics operating in educational institutions specifically, and organisations in general. Contribution/value-add: The understanding about diversity dynamics is available for application, by lecturers and management, to form a different understanding of conscious and unconscious factors impacting on the relationship between the three stakeholders, and subsequently the effectiveness of the three stakeholders in their respective roles. This understanding can also be

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis.

Science.gov (United States)

Fleury, Michelle; Belkina, Anna C; Proctor, Elizabeth A; Zammitti, Christopher; Simms, Robert W; Lauffenburger, Douglas A; Snyder-Cappione, Jennifer E; Lafyatis, Robert; Dooms, Hans

2018-04-01

Immune dysfunction is an important component of the disease process underlying systemic sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. This study was undertaken to measure the expression and function of the coinhibitory receptors (co-IRs) programmed cell death 1 (PD-1), T cell immunoglobulin and ITIM domain (TIGIT), T cell immunoglobulin and mucin domain 3 (TIM-3), and lymphocyte activation gene 3 (LAG-3) in lymphocyte subsets from the peripheral blood of patients with SSc. Co-IR expression levels on subsets of immune cells were analyzed using a 16-color flow cytometry panel. The functional role of co-IRs was determined by measuring cytokine production after in vitro stimulation of SSc and healthy control peripheral blood mononuclear cells (PBMCs) in the presence of co-IR-blocking antibodies. Supernatants from cultures of stimulated PBMCs were added to SSc fibroblasts, and their impact on fibroblast gene expression was measured. Mathematical modeling was used to reveal differences between co-IR functions in SSc patients and healthy controls. Levels of the co-IRs PD-1 and TIGIT were increased, and each was coexpressed, in distinct T cell subsets from SSc patients compared to healthy controls. Levels of TIM-3 were increased in SSc natural killer cells. PD-1, TIGIT, and TIM-3 antibody blockade revealed patient-specific roles of each of these co-IRs in modulating activation-induced T cell cytokine production. In contrast to healthy subjects, blockade of TIGIT and TIM-3, but not PD-1, failed to reverse inhibited cytokine production in SSc patients, indicating that enhanced T cell exhaustion is present in SSc. Finally, cytokines secreted in anti-TIM-3-treated PBMC cultures distinctly changed the gene expression profile in SSc fibroblasts. The altered expression and regulatory capacity of co-IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine-mediated cross-talk of

Argonne lectures on particles accelerator magnets

International Nuclear Information System (INIS)

Devred, A.

1999-09-01

The quest for elementary particles has promoted the development of particle accelerators producing beams of increasingly higher energies. In a synchrotron, the particle energy is directly proportional to the product of the machine's radius times the bending magnets' field strength. Present proton experiments at the TeV scale require facilities with circumferences ranging from a few to tens of kilometers and relying on a large number (several hundred to several thousand) high field dipole magnets and high field gradient quadrupole magnets. These electro-magnets use high-current-density, low-critical-temperature superconducting cables and are cooled down at liquid helium temperature. They are among the most costly and the most challenging components of the machine. After explaining what are the various types of accelerator magnets and why they are needed (lecture 1), we briefly recall the origins of superconductivity and we review the parameters of existing superconducting particle accelerators (lecture 2). Then, we review the superconducting materials that are available at industrial scale (chiefly, NbTi and Nb 3 Sn) and we explain in details the manufacturing of NbTi wires and cables (lecture 3). We also present the difficulties of processing and insulating Nb 3 Sn conductors, which so far have limited the use of this material in spite of its superior performances. We continue by discussing the two dimensional current distributions which are the most appropriate for generating pure dipole and quadrupole fields and we explain how these ideal distributions can be approximated by so called cosθ and cos 2θ coil designs (lecture 4). We also present a few alternative designs which are being investigated and we describe the difficulties of realizing coil ends. Next, we present the mechanical design concepts that are used in existing accelerator magnets (lecture 5) and we describe how the magnets are assembled (lecture 6). Some of the toughest requirements on the

Argonne lectures on particles accelerator magnets

Energy Technology Data Exchange (ETDEWEB)

Devred, A

1999-09-01

The quest for elementary particles has promoted the development of particle accelerators producing beams of increasingly higher energies. In a synchrotron, the particle energy is directly proportional to the product of the machine's radius times the bending magnets' field strength. Present proton experiments at the TeV scale require facilities with circumferences ranging from a few to tens of kilometers and relying on a large number (several hundred to several thousand) high field dipole magnets and high field gradient quadrupole magnets. These electro-magnets use high-current-density, low-critical-temperature superconducting cables and are cooled down at liquid helium temperature. They are among the most costly and the most challenging components of the machine. After explaining what are the various types of accelerator magnets and why they are needed (lecture 1), we briefly recall the origins of superconductivity and we review the parameters of existing superconducting particle accelerators (lecture 2). Then, we review the superconducting materials that are available at industrial scale (chiefly, NbTi and Nb{sub 3}Sn) and we explain in details the manufacturing of NbTi wires and cables (lecture 3). We also present the difficulties of processing and insulating Nb{sub 3}Sn conductors, which so far have limited the use of this material in spite of its superior performances. We continue by discussing the two dimensional current distributions which are the most appropriate for generating pure dipole and quadrupole fields and we explain how these ideal distributions can be approximated by so called cos{theta} and cos 2{theta} coil designs (lecture 4). We also present a few alternative designs which are being investigated and we describe the difficulties of realizing coil ends. Next, we present the mechanical design concepts that are used in existing accelerator magnets (lecture 5) and we describe how the magnets are assembled (lecture 6). Some of the toughest

TIMS-1: a processing code for production of group constants of heavy resonant nuclei

International Nuclear Information System (INIS)

Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi.

1980-09-01

The TIMS-1 code calculates the infinitely dilute group cross sections and the temperature dependent self-shielding factors for arbitrary values of σ 0 and R, where σ 0 is the effective background cross section of potential scattering and R the ratio of the atomic number densities for two resonant nuclei if any. This code is specifically programmed to use the evaluated nuclear data file of ENDF/B or JENDL as input data. In the unresolved resonance region, the resonance parameters and the level spacings are generated by using Monte Carlo method from the Porter-Thomas and Wigner distributions respectively. The Doppler broadened cross sections are calculated on the ultra-fine lethargy meshes of about 10 -3 -- 10 -5 using the generated and resolved resonance parameters. The effective group constants are calculated by solving the neutron slowing down equation with the use of the recurrence formula for the neutron slowing down source. The output of the calculated results is given in a format being consistent with the JAERI-Fast set (JFS) or the Standard Reactor Analysis Code (SRAC) library. Both FACOM 230/75 and M200 versions of TIMS-1 are available. (author)

Video Lecture Capture Technology Helps Students Study without Affecting Attendance in Large Microbiology Lecture Courses

Directory of Open Access Journals (Sweden)

Jennifer Lynn McLean

2016-12-01

Full Text Available Recording lectures using video lecture capture software and making them available for students to watch anytime, from anywhere, has become a common practice in many universities across many disciplines. The software has become increasingly easy to use and is commonly provided and maintained by higher education institutions. Several studies have reported that students use lecture capture to enhance their learning and study for assessments, as well as to catch up on material they miss when they cannot attend class due to extenuating circumstances. Furthermore, students with disabilities and students from non-English Speaking Backgrounds (NESB may benefit from being able to watch the video lecture captures at their own pace. Yet, the effect of this technology on class attendance remains a controversial topic and largely unexplored in undergraduate microbiology education. Here, we show that when video lecture captures were available in our large enrollment general microbiology courses, attendance did not decrease. In fact, the majority of students reported that having the videos available did not encourage them to skip class, but rather they used them as a study tool. When we surveyed NESB students and nontraditional students about their attitudes toward this technology, they found it helpful for their learning and for keeping up with the material.

ACADEMIC TRAINING LECTURE

CERN Multimedia

Academic Training; Tel. 73127

2001-01-01

26, 27, 28 February and 1, 2 March REGULAR LECTURE PROGRAMME From 11:00 hrs - Main Auditorium bldg. 500 Recent Results on CP Violation and B Physics P.F. HARRISON / QMW, London, UK With the advent of the asymmetric B factories in Japan and the US, exciting new results on CP Violation and B Physics are starting to be achieved. In these lectures, we review the existing experimental and phenomenological context of these measurements, we compare and contrast the new experimental facilities and discuss the implications of the recent results on our understanding. Finally we summarise the prospects for future developments.

Lectures for CERN pensioners

CERN Multimedia

GS Department

2009-01-01

The CERN Medical Service and the Pensioners Association are pleased to invite CERN pensioners to a series of lectures given by professors and specialists from the Teaching Hospitals and the Faculty of Medicine of the University of Geneva on the following topic: PROMOTION OF OPTIMUM BRAIN AGEING The lectures will take place in the Main CERN Auditorium (Building 60) from 2.30 p.m. to 4.30 p.m. on the following dates: Thursday 15 January 2009: Diagnosing and treating Alzheimer’s disease Pr Gabriel GOLD Wednesday 25 February 2009: What is the brain reserve? Speaker’s name to be announced at a later date. The lectures will be given in French, with transparencies in English, and will be followed by a wide-ranging debate with the participants. CERN Medical Service - Pensioners Association - CERN-ESO (GAC-EPA)

Frontiers of Physics and Plasma Science

International Nuclear Information System (INIS)

Sharma, Prerana

2017-01-01

Preface to the conference proceedingsWe are very pleased to introduce the proceeding of FPPS-2016; the international conference “Frontiers of Physics and Plasma Science” that took place on 7 and 8 November, 2016 in the campus of Ujjain Engineering College, Ujjain (India). The goal of the meeting was to provide a broad prospective to the plasma science emphasizing physics with a new plasma technologies. The scientific program of the conference focused on the advancement of the all branches of physics in achieving all applications of the plasma science. The conference spans a wide range of topics, reporting experiments, techniques and ideas that advance the plasma science worldwide.There were 20 invited lectures and 04 oral presentations covering the different area of the conference. The keynote lecture was delivered by Dr. Rajdeep Singh Rawat (NTU, Singapore) on “Density plasma focus: novel high energy density plasma device”. Prof. Y.C. Saxena (IPR, Gandhinagar, Ahmedabad), Prof. R. P. Sharma (IIT, New Delhi), Prof. Fernando Haas (Brazil), Prof. Davoud Dorranian (Tehran, Iran), Dr. Raju Khanal (Tribhuwan University, Nepal), Prof. Avinash Khare (IIT, New Delhi), Dr. Navin Dwivedi (Israel), Prof. V.K. Tripathi (IIT New Delhi), Dr. J. Ghosh (IPR, Gandhinagar, Gujarat), Dr. Devendra Sharma (IPR, Gandhinagar, Gujarat), Prof. R.K. Thareja (IIT Kanpur), Dr. Vipul Arora (RRCAT, Indore), Prof. M. P. Bora (Gauhati University, Guwahati) and many more have delivered their lecture in the field of plasma science and its applications. The program was chaired in a professional and efficient way by the session chairmen who were selected for their international standing in the subject.The 165 abstracts that were presented in two days (during parallel poster session) formed a heart of the conference and provided ample opportunity for the discussion. The 170 participants, 110 of whom were students had many fruitful discussions and exchange that contributed to the success of the

Ontology and anthropology of interanimality: Merleau-Ponty from Tim ingold's perspective

Directory of Open Access Journals (Sweden)

Ana Cristina Ramírez Barreto

2010-01-01

Full Text Available This essay explores Tim Ingold’s anthropological theory following his references to Merleau-Ponty and the concept of interanimality/interagentivity. It poses some ideas of Ingold’s “poetics of dwelling”, which he highlights from ethnographies of hunter-gatherer peoples, and how these ideas are linked to an ontological consideration which does not dissociate body and person, body and mind, nature and culture, animality and humanity. The paper reviews animal literature in Merleau-Ponty’s philosophy, and Ingold’s critique of “Anthropology of the senses”. It also gives critical clues for the ethical and political implications of this ontology.

Sand flies in Timóteo, Minas Gerais, Brazil (Diptera: Psychodidae)

OpenAIRE

Andrade Filho, José Dilermando; Carneiro, Ana Paula Salgado; Lima, Mauro Lucio Nascimento; Santiago, Rodrigo Martins; Gama, Marco Antônio; Santos, Carlos Alberto; Falcão, Alda Lima; Brazil, Reginaldo Peçanha

1997-01-01

Casos esporádicos de leishmaniose tegumentar têm ocorrido no Município de Timóteo, Minas Gerais, basicamente na população rural. Para conhecer a fauna de flebotomíneos da região, foram instaladas sete armadilhas luminosas de New Jersey na cidade, em sete diferentes bairros. As coletas foram realizadas no período de junho a outubro de 1994, dezembro de 1994 e janeiro a março de 1995, com um total de 3.240 horas por armadilha. Foram capturados 4.396 flebotomíneos, distribuídos em dois gêneros e...

Feynman Lectures on Gravitation

International Nuclear Information System (INIS)

Borcherds, P

2003-01-01

In the early 1960s Feynman lectured to physics undergraduates and, with the assistance of his colleagues Leighton and Sands, produced the three-volume classic Feynman Lectures in Physics. These lectures were delivered in the mornings. In the afternoons Feynman was giving postgraduate lectures on gravitation. This book is based on notes compiled by two students on that course: Morinigo and Wagner. Their notes were checked and approved by Feynman and were available at Caltech. They have now been edited by Brian Hatfield and made more widely available. The book has a substantial preface by John Preskill and Kip Thorne, and an introduction entitled 'Quantum Gravity' by Brian Hatfield. You should read these before going on to the lectures themselves. Preskill and Thorne identify three categories of potential readers of this book. 1. Those with a postgraduate training in theoretical physics. 2. 'Readers with a solid undergraduate training in physics'. 3. 'Admirers of Feynman who do not have a strong physics background'. The title of the book is perhaps misleading: readers in category 2 who think that this book is an extension of the Feynman Lectures in Physics may be disappointed. It is not: it is a book aimed mainly at those in category 1. If you want to get to grips with gravitation (and general relativity) then you need to read an introductory text first e.g. General Relativity by I R Kenyon (Oxford: Oxford University Press) or A Unified Grand Tour of Theoretical Physics by Ian D Lawrie (Bristol: IoP). But there is no Royal Road. As pointed out in the preface and in the introduction, the book represents Feynman's thinking about gravitation some 40 years ago: the lecture course was part of his attempts to understand the subject himself, and for readers in all three categories it is this that makes the book one of interest: the opportunity to observe how a great physicist attempts to tackle some of the hardest challenges of physics. However, the book was written 40

Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1.

Science.gov (United States)

Darwish, Noureldien H E; Sudha, Thangirala; Godugu, Kavitha; Elbaz, Osama; Abdelghaffar, Hasan A; Hassan, Emad E A; Mousa, Shaker A

2016-09-06

Acute myeloid leukemia (AML) patients show high relapse rates and some develop conventional chemotherapy resistance. Leukemia Stem Cells (LSCs) are the main player for AML relapses and drug resistance. LSCs might rely on the B-cell-specific Moloney murine leukemia virus integration site-1 (BMI-1) in promoting cellular proliferation and survival. Growth of LSCs in microenvironments that are deprived of nutrients leads to up-regulation of the signaling pathways during the progression of the disease, which may illustrate the sensitivity of LSCs to inhibitors of those signaling pathways as compared to normal cells. We analyzed the expression of LSC markers (CD34, CLL-1, TIM-3 and BMI-1) using quantitative RT-PCR in bone marrow samples of 40 AML patients of different FAB types (M1, M2, M3, M4, M5, and M7). We also studied the expression of these markers in 2 AML cell lines (Kasumi-1 and KG-1a) using flow cytometry and quantitative RT-PCR. The overexpression of TIM-3, CLL-1, and BMI-1 was markedly correlated with poor prognosis in these patients. Our in vitro findings demonstrate that targeting BMI-1, which markedly increased in the leukemic cells, was associated with marked decrease in leukemic burden. This study also presents results for blocking LSCs' surface markers CD44, CLL-1, and TIM-3. These markers may play an important role in elimination of AML. Our study indicates a correlation between the expression of markers TIM-3, CLL-1, and especially of BMI-1 and the aggressiveness of AML and thus the potential impact of prognosis and therapies that target LSCs on improving the cure rates.

Electronic voting to encourage interactive lectures: a randomised trial

Directory of Open Access Journals (Sweden)

Palmer Edward

2007-07-01

Full Text Available Abstract Background Electronic Voting Systems have been used for education in a variety of disciplines. Outcomes from these studies have been mixed. Because results from these studies have been mixed, we examined whether an EVS system could enhance a lecture's effect on educational outcomes. Methods A cohort of 127 Year 5 medical students at the University of Adelaide was stratified by gender, residency status and academic record then randomised into 2 groups of 64 and 63 students. Each group received consecutive 40-minute lectures on two clinical topics. One group received the EVS for both topics. The other group received traditional teaching only. Evaluation was undertaken with two, 15-question multiple-choice questionnaires (MCQ assessing knowledge and problem solving and undertaken as a written paper immediately before and after the lectures and repeated online 8–12 weeks later. Standardised institutional student questionnaires were completed for each lecture and independent observers assessed student behaviour during the lectures. Lecturer's opinions were assessed by a questionnaire developed for this study. Results Two-thirds of students randomised to EVS and 59% of students randomised to traditional lectures attended. One-half of the students in the EVS group and 41% in the traditional group completed all questionnaires. There was no difference in MCQ scores between EVS and traditional lectures (p = 0.785. The cervical cancer lectures showed higher student ranking in favour of EVS in all parameters. The breast cancer lectures showed higher ranking in favour of traditional lectures in 5 of 7 parameters (p Conclusion In this setting, EVS technology used in large group lectures did not offer significant advantages over the more traditional lecture format.

Application of TIMS in isotope correlations for determining the isotope ratios of plutonium

International Nuclear Information System (INIS)

Alamelu, D.; Aggarwal, S.K.

2003-01-01

Thermal ionisation mass spectrometry (TIMS) is a well-recognized technique for determining the isotopic composition of Pu in irradiated nuclear fuel samples. Other mass spectrometric methods such as ICPMS, SIMS can also be employed for the isotopic analysis of Pu. In the event of non-availability of a mass spectrometer, other techniques such as gamma spectrometry and alpha spectrometry can also be used. They have a limited applicability since data on all the Pu isotopes cannot be obtained

Proceedings of Japan-Germany Workshop of Bioremediation; Nichidoku bio remediation workshop hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-04

This is a proceedings of Japan-Germany Workshop on Bioremediation held on December 4 and 5, 1995. The keynote lectures include `Environmental preservation using biotechnology` by Prof. Karube of University of Tokyo, and `Environmental technology in Germany: status, achievements, and problems` by Prof. R.D.Schmid of University of Stuttgart. In the oral session, 7 papers are presented in the microbiological aspects of bioremediation, 10 papers in the environmental monitoring, and 6 papers in the engineering aspects of bioremediation. This workshop was sponsored by the German Federal Ministry for Education, Science and Technology, New Energy and Industrial Technology Development Organization, and Research Institute of Innovative Technology for the Earth. According to the lecture by Prof. Karube, key technologies for the environmental preservation include biotechnologies, such as the culture of fine algae with high CO2 concentration resistant properties using a solar light condenser, production of effective substances from CO2, and production of organic fertilizer from the sediments of lakes and sea. 19 refs., 12 figs., 3 tabs.

Van autonomie terug naar natuurlijk­heid? Een reactie op prof.dr. H.M. Dupuis

NARCIS (Netherlands)

Boer, Th.A.

Wie de inleidingen van Prof. Dupuis en Mgr. Eijk leest, kan zich moeilijk aan de indruk onttrekken dat zij het onderling behoorlijk eens zijn. Dat verbaast, want Eijk staat bekend als een aanhanger van het natuurrecht zoals geïnterpreteerd in de rooms-katholieke traditie en Dupuis als een

Response to Tim Barringer, A White Atlantic?

Directory of Open Access Journals (Sweden)

Kate Flint

2009-11-01

Full Text Available In my response to Tim Barringer’s piece, I emphasize the importance of extending one’s frame of reference when discussing transatlantic artistic connections to the consideration of as many different art forms as possible – including photography, and magazine and book illustrations – in order to get as full a picture as possible of the two-way flow in transatlantic artistic influences.This fuller picture notably extends the degree to which images of non-white subjects are seen to be in circulation. I also draw attention to the ways in which American and English artistic circles intersected outside as well as within these two countries, a point reinforced by looking at American women sculptors in Rome in the 1860s, paying particular attention to the work of the part African-American, part Native American sculptor, Edmonia Lewis. In her work can be seen a complex set of attitudes towards her subject matter that remind one forcefully of the many racial and cultural strands coming together in new American art.

Public Lecture: The Odyssey of Voyager

CERN Multimedia

CERN. Geneva

2015-01-01

Should you wish to attend to this lecture only (and not the full colloquium), please register here: https://indico.cern.ch/event/387001/registration/ Participants to the full colloquium are automatically registered to the public lectures.

Prof Dr Zeki Soysal’a Saygı İle

Directory of Open Access Journals (Sweden)

Sermet Koç

2006-12-01

�oğunu gece yarılarına kadar, odasında asistanları ile kitap yazarak geçirmeye devam etmişti. Ömrünün son günlerinde camiamızda yaşanılan ayrılıklardan, sorunlardan dolayı da çok üzgündü. Camiamızda fırtına koparılan o puslu günlerde kendisine gelerek ATUD’dan ayrılmasını isteyenleri bir türlü anlamadığını, sık sık hayıflandığını hatırlıyorum. Hele Adli Tıp Kurumu’nun eski kendi mekanından aniden taşınma kararına hiç anlam verememişti ve yaşanılan gelişmelerin pek hayra olmadığını ifade etmişti. Onu yitirdiğimizde, çok yalnız kaldığımızı hissettim, ama herkes adına, tüm camia adına. Anabilim dalımız, ondan sonraki ilk akademik kurul toplantısında, odasına “Prof. Dr. Zeki Soysal Çalışma Odası ve Kitaplığı" adını verme kararını aldı ve bu öneri üniversite yönetiminin 20.06.2006 tarih 27036 sayılı kararı ile kabul edildi. Belki bir gün, kapısını açar, konuklarını kabul ederiz; çay kahve ikram ederiz, el yazısı çalışmalarından birkaç sayfa sunarız; yani beraber olmanın, birlikte olmanın güzelliğini belki hatırlarız,., diyedir. Belki de, bir gün “Prof. Dr. Zeki Soysal Adli Obstetrik ve Jinekoloji Günleri” diye başlayacak olan günlerde oda ziyaretleri yaparız, kim bilir? Şu ‘gri’ anımı yazmadan geçemeyeceğim: Zeki Abi’nin, özellikle vasiyetinde de belirttiği gibi “en güzel günlerinde” zevkle yaptığı eğitim otopsilerinin, bir çok asistan ve öğrencinin yetişmesinde büyük payı vardır. Kendisi, bu en az üç dört saat süren otopsi seanslarında; hem cerrah, hem de adli tıpçı olmasının verdiği hünerle olsa gerek; bir “otopsi virtüözü” gibi sanatını icra ederdi. Bu nedenle, o acımasız hastalığa tutulduğu ve ümitlerimizi büyük ölçüde yitirdiğimiz günlerde. Kurum Başkanı’nı ziyaret ederek. Otopsi Salonu’na adının verilmesini önermiştim, ... , şimdi ne yazık ki kapışma kilit vurulan bu

Impact of abbreviated lecture with interactive mini-cases vs traditional lecture on student performance in the large classroom.

Science.gov (United States)

Marshall, Leisa L; Nykamp, Diane L; Momary, Kathryn M

2014-12-15

To compare the impact of 2 different teaching and learning methods on student mastery of learning objectives in a pharmacotherapy module in the large classroom setting. Two teaching and learning methods were implemented and compared in a required pharmacotherapy module for 2 years. The first year, multiple interactive mini-cases with inclass individual assessment and an abbreviated lecture were used to teach osteoarthritis; a traditional lecture with 1 inclass case discussion was used to teach gout. In the second year, the same topics were used but the methods were flipped. Student performance on pre/post individual readiness assessment tests (iRATs), case questions, and subsequent examinations were compared each year by the teaching and learning method and then between years by topic for each method. Students also voluntarily completed a 20-item evaluation of the teaching and learning methods. Postpresentation iRATs were significantly higher than prepresentation iRATs for each topic each year with the interactive mini-cases; there was no significant difference in iRATs before and after traditional lecture. For osteoarthritis, postpresentation iRATs after interactive mini-cases in year 1 were significantly higher than postpresentation iRATs after traditional lecture in year 2; the difference in iRATs for gout per learning method was not significant. The difference between examination performance for osteoarthritis and gout was not significant when the teaching and learning methods were compared. On the student evaluations, 2 items were significant both years when answers were compared by teaching and learning method. Each year, students ranked their class participation higher with interactive cases than with traditional lecture, but both years they reported enjoying the traditional lecture format more. Multiple interactive mini-cases with an abbreviated lecture improved immediate mastery of learning objectives compared to a traditional lecture format, regardless of

Towards Automated Lecture Capture, Navigation and Delivery System for Web-Lecture on Demand

OpenAIRE

Kannan, Rajkumar; Andres, Frederic

2010-01-01

Institutions all over the world are continuously exploring ways to use ICT in improving teaching and learning effectiveness. The use of course web pages, discussion groups, bulletin boards, and e-mails have shown considerable impact on teaching and learning in significant ways, across all disciplines. ELearning has emerged as an alternative to traditional classroom-based education and training and web lectures can be a powerful addition to traditional lectures. They can even serve as a main c...

CCHMM_PROF: a HMM-based coiled-coil predictor with evolutionary information

DEFF Research Database (Denmark)

Bartoli, Lisa; Fariselli, Piero; Krogh, Anders

2009-01-01

tools are available for predicting coiled-coil domains in protein sequences, including those based on position-specific score matrices and machine learning methods. RESULTS: In this article, we introduce a hidden Markov model (CCHMM_PROF) that exploits the information contained in multiple sequence...... alignments (profiles) to predict coiled-coil regions. The new method discriminates coiled-coil sequences with an accuracy of 97% and achieves a true positive rate of 79% with only 1% of false positives. Furthermore, when predicting the location of coiled-coil segments in protein sequences, the method reaches...

Prof. Dr. C. J. H. De Wet. (’n Persoonlike waardering.

Directory of Open Access Journals (Sweden)

J. C. Coetzee

1959-03-01

Full Text Available Ek het prof. De Wet vir eerste maal ontmoet toe hy aan die begin van1912 student geword het aan die Teologiese Skool van die Gereformeerde Kerkop Potchefstroom. Ek was toe student aan dieselfde inrigting en in my laastejaar vir die graad B.A. Hy was onder ons studente bekend as 'n hardwerkend een baie begaafde jongman. In ons studenteverenigings en -samenkomste het hy hom openbaar -as iemand met ’n breedheid van insig en ’n helderheid van formulering wat kenmerkend gedurende sy hele latere optrede sou wees.

Lectures on Chevalley groups

CERN Document Server

Steinberg, Robert

2016-01-01

Robert Steinberg's Lectures on Chevalley Groups were delivered and written during the author's sabbatical visit to Yale University in the 1967-1968 academic year. The work presents the status of the theory of Chevalley groups as it was in the mid-1960s. Much of this material was instrumental in many areas of mathematics, in particular in the theory of algebraic groups and in the subsequent classification of finite groups. This posthumous edition incorporates additions and corrections prepared by the author during his retirement, including a new introductory chapter. A bibliography and editorial notes have also been added. This is a great unsurpassed introduction to the subject of Chevalley groups that influenced generations of mathematicians. I would recommend it to anybody whose interests include group theory. -Efim Zelmanov, University of California, San Diego Robert Steinberg's lectures on Chevalley groups were given at Yale University in 1967. The notes for the lectures contain a wonderful exposition of ...

Lectures for CERN pensioners

CERN Multimedia

SC Unit

2008-01-01

The CERN Medical Service and the Pensioners Association are pleased to invite CERN pensioners to a series of lectures given by professors and specialists from the Teaching Hospitals and the Faculty of Medicine of the University of Geneva on the following topic: PROMOTION OF OPTIMUM BRAIN AGEING The lectures will take place in the Main CERN Auditorium (Building 60) from 2.30 p.m. to 4.30 p.m. on the following dates: Wednesday 12 November 2008: Assessing the extent of brain ageing Dr Dina ZEKRY Friday 12 December 2008: Can memory decline be prevented? Pr Jean-Pierre MICHEL Thursday 15 January 2009: Diagnosing and treating Alzheimer’s disease Pr Gabriel GOLD Wednesday 25 February 2009: What is the brain reserve? Speaker’s name to be announced at a later date The lectures will be given in French, with transparencies in English, and will be followed by a wide-ranging debate with the participants. CERN Medical Service - Pensioners Association - CERN-ESO (GAC-EPA)

Lectures on functor homology

CERN Document Server

Touzé, Antoine

2015-01-01

This book features a series of lectures that explores three different fields in which functor homology (short for homological algebra in functor categories) has recently played a significant role. For each of these applications, the functor viewpoint provides both essential insights and new methods for tackling difficult mathematical problems. In the lectures by Aurélien Djament, polynomial functors appear as coefficients in the homology of infinite families of classical groups, e.g. general linear groups or symplectic groups, and their stabilization. Djament’s theorem states that this stable homology can be computed using only the homology with trivial coefficients and the manageable functor homology. The series includes an intriguing development of Scorichenko’s unpublished results. The lectures by Wilberd van der Kallen lead to the solution of the general cohomological finite generation problem, extending Hilbert’s fourteenth problem and its solution to the context of cohomology. The focus here is o...

Lectures on quasiconformal mappings

CERN Document Server

Ahlfors, Lars V

2006-01-01

Lars Ahlfors's Lectures on Quasiconformal Mappings, based on a course he gave at Harvard University in the spring term of 1964, was first published in 1966 and was soon recognized as the classic it was shortly destined to become. These lectures develop the theory of quasiconformal mappings from scratch, give a self-contained treatment of the Beltrami equation, and cover the basic properties of Teichm�ller spaces, including the Bers embedding and the Teichm�ller curve. It is remarkable how Ahlfors goes straight to the heart of the matter, presenting major results with a minimum set of prerequisites. Many graduate students and other mathematicians have learned the foundations of the theories of quasiconformal mappings and Teichm�ller spaces from these lecture notes. This edition includes three new chapters. The first, written by Earle and Kra, describes further developments in the theory of Teichm�ller spaces and provides many references to the vast literature on Teichm�ller spaces and quasiconformal ...

The Impact of Online Lecture Recordings on Student Performance

Science.gov (United States)

Williams, Andrew; Birch, Elisa; Hancock, Phil

2012-01-01

The use of online lecture recordings as a supplement to physical lectures is an increasingly popular tool at many universities. This paper combines survey data with student record data for students in a "Microeconomics Principles" class to examine the relative effects of lecture attendance and online lecture recordings. The main finding…

Professor Paul Crutzen, the winner of the Nobel prize: The discovery of the ozone hole - knowledge and vision; Nobelpreistraeger Prof. Paul Crutzen: Entdeckung des Ozonlochs - Wissen und Vision

Energy Technology Data Exchange (ETDEWEB)

Crutzen, P.; Dellert-Ritter, M.

1997-02-01

On 10 December 1995, Professor Crutzen was awarded the Nobel prize for his epoch-making achievements in the field of atmospheric chemistry. This award underlines also Professor Crutzen`s commitment to the protection of the atmosphere. The atmospheric researcher discovered how sensitively the ozone layer reacts to air pollution. His work, together with that of others, led to the ban on ozone-depleting chlorofluorocarbons. As early as in 1970, Professor Crutzen demonstrated that nitrogen oxides react catalytically with ozone. His think tank provided numerous stimuli for further, intense research on atmospheric chemistry, which triggered a debate on the protection of the thinning ozone layer also among politicians. (orig.) [Deutsch] Am 10. Dezember 1995 wurde Prof. Crutzen fuer seine bahnbrechenden Leistungen auf dem Gebiet der Atmosphaerenchemie mit dem Nobelpreis geehrt. Diese Anerkennung unterstreicht auch das Engagement von Prof. Crutzen zum Schutz der Ozonschicht. Der Atmosphaerenforscher Prof. Crutzen entdeckte, wie empfindlich die Ozonschicht auf Luftverunreinigungen reagiert. Seine Arbeiten fuehrten mit zum Verbot der ozonvernichtenden Fluorchlorkohlenwasserstoffe. Bereits 1970 wies Prof. Crutzen nach, dass Stickstoffoxide katalytisch mit Ozon reagieren. Aus der Ideenfabrik von Prof. Crutzen kamen zahlreiche Anregungen fuer weitere intensive Forschungen zur Chemie der Atmosphaere, die auch unter Politikern eine Debatte ueber den Schutz der hauchduennen Ozonschicht ausloeste. (orig.)

"Annotated Lectures": Student-Instructor Interaction in Large-Scale Global Education

Directory of Open Access Journals (Sweden)

Roger Diehl

2009-10-01

Full Text Available We describe an "Annotated Lectures" system, which will be used in a global virtual teaching and student collaboration event on embodied intelligence presented by the University of Zurich. The lectures will be broadcasted via video-conference to lecture halls of different universities around the globe. Among other collaboration features, an "Annotated Lectures" system will be implemented in a 3D collaborative virtual environment and used by the participating students to make annotations to the video-recorded lectures, which will be sent to and answered by their supervisors, and forwarded to the lecturers in an aggregated way. The "Annotated Lectures" system aims to overcome the issues of limited studentinstructor interaction in large-scale education, and to foster an intercultural and multidisciplinary discourse among students who review the lectures in a group. After presenting the concept of the "Annotated Lectures" system, we discuss a prototype version including a description of the technical components and its expected benefit for large-scale global education.

Interactive lectures: Clickers or personal devices?

Science.gov (United States)

Morrell, Lesley J; Joyce, Domino A

2015-01-01

Audience response systems ('clickers') are frequently used to promote participation in large lecture classes, and evidence suggests that they convey a number of benefits to students, including improved academic performance and student satisfaction. The limitations of these systems (such as limited access and cost) can be overcome using students' personal electronic devices, such as mobile phones, tablets and laptops together with text message, web- or app-based polling systems. Using questionnaires, we compare student perceptions of clicker and smartphone based polling systems. We find that students prefer interactive lectures generally, but those that used their own device preferred those lectures over lectures using clickers. However, device users were more likely to report using their devices for other purposes (checking email, social media etc.) when they were available to answer polling questions. These students did not feel that this distracted them from the lecture, instead, concerns over the use of smartphones centred around increased battery usage and inclusivity for students without access to suitable technology. Our results suggest that students generally preferred to use their own devices over clickers, and that this may be a sensible way to overcome some of the limitations associated with clickers, although issues surrounding levels of distraction and the implications for retention and recall of information need further investigation.

Active Learning in ASTR 101 Lectures

Science.gov (United States)

Deming, Grace L.

1998-12-01

The lecture is the most common teaching method used at colleges and universities, but does this format facilitate student learning? Lectures can be brilliantly delivered, but they are received by a passive audience. As time passes during a lecture, student attention and effective notetaking diminish. Many students become more interested in a subject and retain information longer in courses that rely on active rather than passive teaching methods. Interactive teaching strategies such as the think-pair-share-(write), the 3-minute paper, and the misconception confrontation can be used to actively engage students during lecture. As a cooperative learning strategy, the think-pair-share-(write) technique requires active discussion by everyone in the class. The "write" component structures individual accountability into the activity. The 3-minute paper is an expansion of the standard 1-minute paper feedback technique, but is required of all students rather than voluntary or anonymous. The misconception confrontation technique allows students to focus on how their pre- conceived notions differ from the scientific explanation. These techniques can be easily adopted by anyone currently using a standard lecture format for introductory astronomy. The necessary components are a commitment by the instructor to require active participation by all students and a willingness to try new teaching methods.

Interactive Lecture Experiments in Large Introductory Physics Classes

Science.gov (United States)

Milner-Bolotin, Marina M.; Kotlicki, A.; Rieger, G.; Bates, F.; Moll, R.; McPhee, K.; Nashon, S.

2006-12-01

We describe Interactive Lecture Experiments (ILE), which build on Interactive Lecture Demonstrations proposed by Sokoloff and Thornton (2004) and extends it by providing students with the opportunity to analyze experiments demonstrated in the lecture outside of the classroom. Real time experimental data is collected, using Logger Pro combined with the digital video technology. This data is uploaded to the Internet and made available to the students for further analysis. Student learning is assessed in the following lecture using conceptual questions (clickers). The goal of this project is to use ILE to make large lectures more interactive and promote student interest in science, critical thinking and data analysis skills. We report on the systematic study conducted using the Colorado Learning Attitudes about Science Survey, Force Concept Inventory, open-ended physics problems and focus group interviews to determine the impact of ILE on student academic achievement, motivation and attitudes towards physics. Three sections of students (750 students) experienced four ILE experiments. The surveys were administered twice and academic results for students who experienced the ILE for a particular topic were compared to the students, from a different section, who did not complete the ILE for that topic. Additional qualitative data on students’ attitudes was collected using open ended survey questions and interviews. We will present preliminary conclusions about the role of ILEs as an effective pedagogy in large introductory physics courses. Sokoloff, D.R. and R.K. Thornton (2004). Interactive Lecture Demonstrations: Active Learning in Introductory Physics, J.Wiley & Sons, INC. Interactive Lecture Experiments: http://www.physics.ubc.ca/ year1lab/p100/LectureLabs/lectureLabs.html

Twenty lectures on thermodynamics

CERN Document Server

Buchdahl, H A

2013-01-01

Twenty Lectures on Thermodynamics is a course of lectures, parts of which the author has given various times over the last few years. The book gives the readers a bird's eye view of phenomenological and statistical thermodynamics. The book covers many areas in thermodynamics such as states and transition; adiabatic isolation; irreversibility; the first, second, third and Zeroth laws of thermodynamics; entropy and entropy law; the idea of the application of thermodynamics; pseudo-states; the quantum-static al canonical and grand canonical ensembles; and semi-classical gaseous systems. The text

Lectures on Quantum Mechanics

CERN Document Server

Dirac, Paul Adrien Maurice

1964-01-01

The author of this concise, brilliant series of lectures on mathematical methods in quantum mechanics was one of the shining intellects in the field, winning a Nobel prize in 1933 for his pioneering work in the quantum mechanics of the atom. Beyond that, he developed the transformation theory of quantum mechanics (which made it possible to calculate the statistical distribution of certain variables), was one of the major authors of the quantum theory of radiation, codiscovered the Fermi-Dirac statistics, and predicted the existence of the positron.The four lectures in this book were delivered

Prof. Oscar Vogt (1927 - 2014)

International Nuclear Information System (INIS)

Wachter, Peter

2014-01-01

On 21st. Jan. 2014 Oscar Vogt left us. Born in 1927, he lived a long and fulfilling life. One of us (PW) first met Oscar Vogt and his wife Ditta in 1962, when we both investigated in the Laboratorium für Festkörperphysik of ETH Zürich (Swiss Federal Institute of Technology) the magnetic properties of rare-earth compounds. Oscar was a son of the owner of Vogt and Co. (VoCo), a wire-fabrication company, which could also make exotic wires like tungsten. He received his PhD at ETH Zürich with Prof G. Busch, who When his father died in the 1970s, Oscar faced a choice – physics or the family business. He managed both! Every Monday he spent in the Institute, and with his competent technical assistant Kurt Mattenberger, grew large and welldefined single crystals of rare-earth compounds and investigated their magnetic properties. The production of crystals was especially challenging as these compounds melt only near 2000 °C, and special tungsten crucibles had to be maintained at g , mentioned that he was the only graduate student not asking for payment. He enjoyed interesting hobbies and was much involved in cultural activities. He engaged himself with great enthusiasm, initially in the research of rareearth compounds, and then later in the actinides.We had a long-lasting and fruitful friendship

The Effect of Instant Messaging on Lecture Retention

Science.gov (United States)

McVaugh, Nathan Kant

2012-01-01

The impact of instant message interruptions via computer on immediate lecture retention for college students was examined. While watching a 24-minute video of a classroom lecture, students received various numbers of related-to-lecture ("Is consistent use of the eye contact method necessary for success?") versus not-related-to lecture…

Online Lectures in Undergraduate Medical Education: Scoping Review.

Science.gov (United States)

Tang, Brandon; Coret, Alon; Qureshi, Aatif; Barron, Henry; Ayala, Ana Patricia; Law, Marcus

2018-04-10

The adoption of the flipped classroom in undergraduate medical education calls on students to learn from various self-paced tools-including online lectures-before attending in-class sessions. Hence, the design of online lectures merits special attention, given that applying multimedia design principles has been shown to enhance learning outcomes. The aim of this study was to understand how online lectures have been integrated into medical school curricula, and whether published literature employs well-accepted principles of multimedia design. This scoping review followed the methodology outlined by Arksey and O'Malley (2005). Databases, including MEDLINE, PsycINFO, Education Source, FRANCIS, ERIC, and ProQuest, were searched to find articles from 2006 to 2016 related to online lecture use in undergraduate medical education. In total, 45 articles met our inclusion criteria. Online lectures were used in preclinical and clinical years, covering basic sciences, clinical medicine, and clinical skills. The use of multimedia design principles was seldom reported. Almost all studies described high student satisfaction and improvement on knowledge tests following online lecture use. Integration of online lectures into undergraduate medical education is well-received by students and appears to improve learning outcomes. Future studies should apply established multimedia design principles to the development of online lectures to maximize their educational potential. ©Brandon Tang, Alon Coret, Aatif Qureshi, Henry Barron, Ana Patricia Ayala, Marcus Law. Originally published in JMIR Medical Education (http://mededu.jmir.org), 10.04.2018.

AVIRIS and TIMS data processing and distribution at the land processes distributed active archive center

Science.gov (United States)

Mah, G. R.; Myers, J.

1993-01-01

The U.S. Government has initiated the Global Change Research program, a systematic study of the Earth as a complete system. NASA's contribution of the Global Change Research Program is the Earth Observing System (EOS), a series of orbital sensor platforms and an associated data processing and distribution system. The EOS Data and Information System (EOSDIS) is the archiving, production, and distribution system for data collected by the EOS space segment and uses a multilayer architecture for processing, archiving, and distributing EOS data. The first layer consists of the spacecraft ground stations and processing facilities that receive the raw data from the orbiting platforms and then separate the data by individual sensors. The second layer consists of Distributed Active Archive Centers (DAAC) that process, distribute, and archive the sensor data. The third layer consists of a user science processing network. The EOSDIS is being developed in a phased implementation. The initial phase, Version 0, is a prototype of the operational system. Version 0 activities are based upon existing systems and are designed to provide an EOSDIS-like capability for information management and distribution. An important science support task is the creation of simulated data sets for EOS instruments from precursor aircraft or satellite data. The Land Processes DAAC, at the EROS Data Center (EDC), is responsible for archiving and processing EOS precursor data from airborne instruments such as the Thermal Infrared Multispectral Scanner (TIMS), the Thematic Mapper Simulator (TMS), and Airborne Visible and Infrared Imaging Spectrometer (AVIRIS). AVIRIS, TIMS, and TMS are flown by the NASA-Ames Research Center ARC) on an ER-2. The ER-2 flies at 65000 feet and can carry up to three sensors simultaneously. Most jointly collected data sets are somewhat boresighted and roughly registered. The instrument data are being used to construct data sets that simulate the spectral and spatial

Book review: Social Research: Issues, Methods and Process, 3rd edition, by Tim May, Open University Press, 2001, ISBN 0335206123

OpenAIRE

Jones, Keith

2004-01-01

The great strength of this book by Tim May ("Social Research: Issues, Methods and Process", 3rd edition ) is its successful negotiation (perhaps navigation) of the relationships between theory and method in (social) research.

Una década de la Tarjeta de Identidad de Menores (TIM

Directory of Open Access Journals (Sweden)

Eugenia Ma. Zamora Chavarría

2013-07-01

Full Text Available El documento de identidad de las personas difiere de su derecho a la identidad, propiamente dicho; uno y otro se encuentran estrechamente relacionados y el primero tiene la virtud de acreditar, de una manera inmediata y directa, frente a la comunidad, al segundo. Este artículo ofrece una serie de reflexiones alrededor del derecho al nombre y al concepto de identidad. Se centra en el documento denominado Tarjeta de Identidad para Costarricenses de Doce a Dieciocho Años, conocida popularmente como la Ley TIM y repasa lo actuado por el Tribunal en relación con este documento.

Lecturing and Loving It: Applying the Information-Processing Model.

Science.gov (United States)

Parker, Jonathan K.

1993-01-01

Discusses the benefits of lecturing, when done properly, in high schools. Describes the positive attributes of effective lecturers. Provides a human information-processing model applicable to the task of lecturing to students. (HB)

Summer Student Lecture Programme

CERN Multimedia

2004-01-01

Main Auditorium, bldg. 500 More Information DATE TIME LECTURER TITLE Wednesday 7 July 09:15 - 10:00 L. Fayard, O. Ullaland, D. Heagerty (CERN) Programme Presentation Workshops presentation Information on Computing Rules 10:15 - 11:00 R. Aymar (CERN) Introduction to CERN (1/2) 11:15 - 12:00 J. Engelen (CERN) Introduction to CERN (2/2) 15:00 - 16:30 H. Menzel (CERN) An Introduction to Radiation Protection DATE TIME LECTURER TITLE Thursday 8 july 09:15 - 10:00 L. Di Lella (CERN) Introduction to Particle Physics (1/4) 10:15 - 11:00 L. Di Lella (CERN) Introduction to Particle Physics (2/4) 11:15 - 12:00 P. Chomaz (GANIL / CERN) Fundamental questions in modern nuclear physics: The challenge of exotic nuclei (1/2) DATE TIME LECTURER TITLE Friday 9 July 09:15 - 10:00 L. Di Lella (CERN) Introduction to Particle Physics (3/4) 10:15 - 11:00 P. Chomaz (GANIL / CERN) Fundamental questions in modern nuclear physics: The challenge of exotic nuclei (2/2) 11:15 - 12:00 P....

Keynote Addresses from the Horace Mann Lecture Series and the Paul Masoner International Lecture Series 1972-1978.

Science.gov (United States)

Bender, Mary, Ed.

The document contains eight lectures addressing a variety of educational trends, issues, and concerns. The objective is to heighten the awareness of educational challenges that must be met and to promote continued professional renewal activities. Lecture I discusses fundamental problems concerning world education, concentrating on hunger and…

On performing concepts during science lectures

Science.gov (United States)

Pozzer-Ardenghi, Lilian; Roth, Wolff-Michael

2007-01-01

When lecturing, teachers make use of both verbal and nonverbal communication. What is called teaching, therefore, involves not only the words and sentences a teacher utters and writes on the board during a lesson, but also all the hands/arms gestures, body movements, and facial expressions a teacher performs in the classroom. All of these communicative modalities constitute resources that are made available to students for making sense of and learning from lectures. Yet in the literature on teaching science, these other means of communication are little investigated and understood - and, correspondingly, they are undertheorized. The purpose of this position paper is to argue for a different view of concepts in lectures: they are performed simultaneously drawing on and producing multiple resources that are different expressions of the same holistic meaning unit. To support our point, we provide examples from a database of 26 lectures in a 12th-grade biology class, where the human body was the main topic of study. We analyze how different types of resources - including verbal and nonverbal discourse and various material artifacts - interact during lectures. We provide evidence for the unified production of these various sense-making resources during teaching to constitute a meaning unit, and we emphasize particularly the use of gestures and body orientations inside this meaning unit. We suggest that proper analyses of meaning units need to take into account not only language and diagrams but also a lecturer's pointing and depicting gestures, body positions, and the relationships between these different modalities. Scientific knowledge (conceptions) exists in the concurrent display of all sense-making resources, which we, following Vygotsky, understand as forming a unit (identity) of nonidentical entities.

Student Use of Mobile Devices in University Lectures

Science.gov (United States)

Roberts, Neil; Rees, Michael

2014-01-01

Mobile devices are increasingly used by students in university lectures. This has resulted in controversy and the banning of mobile devices in some lectures. Although there has been some research into how students use laptop computers in lectures, there has been little investigation into the wider use of mobile devices. This study was designed to…

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1).

Science.gov (United States)

Ribnicky, David M; Roopchand, Diana E; Oren, Andrew; Grace, Mary; Poulev, Alexander; Lila, Mary Ann; Havenaar, Robert; Raskin, Ilya

2014-01-01

The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions. Blueberry polyphenol-rich extract was delivered to TIM-1 in the absence or presence of a high-fat meal. HPLC analysis of seventeen anthocyanins showed that delphinidin-3-glucoside, delphinidin-3-galactoside, delphinidin-3-arabinoside and petunidin-3-arabinoside were twice as bioaccessible in fed state, whilst delphinidin-3-(6″-acetoyl)-glucoside and malvidin-3-arabinoside were twice as bioaccessible under fasted conditions, suggesting lipid-rich matrices selectively effect anthocyanin bioaccessibility. TIM-1 was fed blueberry juice (BBJ) or blueberry polyphenol-enriched defatted soybean flour (BB-DSF) containing equivalent amounts of free or DSF-sorbed anthocyanins, respectively. Anthocyanin bioaccessibility from BB-DSF (36.0±10.4) was numerically, but not significantly, greater than that from BBJ (26.3±10.3). Ileal efflux samples collected after digestion of BB-DSF contained 2.8-fold more anthocyanins than same from BBJ, suggesting that protein-rich DSF protects anthocyanins during transit through upper digestive tract for subsequent colonic delivery/metabolism. Copyright © 2013 Elsevier Ltd. All rights reserved.

Perceptions of Students and Self- assessment of Lecturers on ...

African Journals Online (AJOL)

assessments of lecturers on written essay error feedback. Overall 153 University of Botswana students and 20 lecturers participated in this study. All the students and 12 lecturers completed different but related questionnaires with both closed and ...

Lectures Abandoned: Active Learning by Active Seminars

DEFF Research Database (Denmark)

Christensen, Henrik Bærbak; Corry, Aino Vonge

2012-01-01

Traditional lecture-based courses are widely criticised for be- ing less eective in teaching. The question is of course what should replace the lectures and various active learning tech- niques have been suggested and studied. In this paper, we report on our experiences of redesigning a software ......- tive seminars as a replacement of traditional lectures, an activity template for the contents of active seminars, an ac- count on how storytelling supported the seminars, as well as reports on our and the students' experiences....

Academician A.M. Prokhorov and femto-atto-photoelectronics: a memorial lecture

Science.gov (United States)

Schelev, Mikhail Y.

2003-07-01

The Great Russian physicist Academician A.M. Prokhorov passed away on the 8th of January 2002 in Moscow. He was born in Australia (Atorton Town) on the 11th of July 1916. Together with Academician N.G. Basov and Prof. C.H. Townes in 1964, he received the Nobel Prize in physics for discovery the fundamental operational principles of the LASER (Light Amplification by Stimulated Emission and Radiation). Among the great variety of scientific and technological areas to which Academician A.M. Prokhorov had devoted his extraordinary talent and his encyclopedical knowledge in physics, is the ultrafast photoelectronics and in particular image-converter high-speed photography. As early as at the beginning of the sixties, he clearly realized the importance and valuability of ultrafast image tubes application for gaining direct visual information in laser research. It was Academician A.M. Prokhorov who had initiated the image tube photography development specially oriented for laser investigations, providing steadily improvement of its time resolution starting from subnanosecond level in the sixties of the 20th Century down to subfemtosecond level at the beginning of the 21st Century. The new area of high-speed research, known as Femto-Attosecond Photoelectronics, is now established as the outstanding result of his imaginative efforts. In this memorial lecture some important achievements in the ultrafast photoelectronics attained under Academician A.M. Prokhorov supervision will be pointed out. Memorized are some perspective targets in high-speed image-converter photography to which Academician A.M. Prokhorov has been concerned during the last period of his brilliant and creative life.

The Challenges of Listening to Academic Lectures for EAP Learners and the Impact of Metacognition on Academic Lecture Listening Comprehension

Directory of Open Access Journals (Sweden)

Maryam Rahimirad

2015-06-01

Full Text Available Academic listening skill is an indispensable necessity for English for academic purposes (EAP students in English-medium universities and also critical for their future success in comprehending conference lectures. But due to the specific nature of such academic lectures, nonnative students all too often face challenges in getting a full command of this task. This study investigates the challenges of listening to academic lectures and the impact of related metacognitive strategies on academic lecture listening comprehension on a group of Iranian learners in an EAP workshop. Fifteen academic staff who took part in two intact classes at the University of Qom, Iran, were randomly assigned to treatment (N = 8 and control (N = 7 groups. The treatment group received 16 hr of metacognitive strategy instruction based on the models proposed by Vandergrift during academic listening instruction, while the control group was just exposed to academic lectures with no explicit strategy instruction. The academic listening sections of the British International English Language Testing System (IELTS were utilized to measure the listening comprehension of both groups before and after the treatment. The results of the data analysis determined that the experimental group significantly outperformed the control group in the listening posttest. The interviews before and after the treatment revealed details of challenges in academic lecture comprehension and also shed light on the perception of the learners regarding metacognitive strategy instruction and the frequency of main metacognitive strategies used in comprehending academic lectures.

RLE Progress Report Number 122.

Science.gov (United States)

1980-01-01

Hosford R.M. Brown Prof. W.M. Siebert Dr. N.Y.S. Kiang A.H. Crist Prof. T.F. Weiss Dr. M.J. Mulroy D.C. Galley Dr. T.R. Bourk Dr. W.M. Rabinowitz E.M. Marr...Research Scientists Durlach, Nathaniel I. Klatt, Dennis H. Principal Research Scientists Colburn, H. Steven Melngailis, John Lecturers Bourk , Terrance...R. Gruberg, Edward R. Plotkin, George M. Widin, Gregory P. Research Staff Antonsen, Thomas M., Jr. Englade, Ronald C. Hunnicutt, M. Sharon Barrett

A TIMS-based method for the high precision measurements of the three-isotope potassium composition of small samples

DEFF Research Database (Denmark)

Wielandt, Daniel Kim Peel; Bizzarro, Martin

2011-01-01

A novel thermal ionization mass spectrometry (TIMS) method for the three-isotope analysis of K has been developed, and ion chromatographic methods for the separation of K have been adapted for the processing of small samples. The precise measurement of K-isotopes is challenged by the presence of ...

Should Lecture Recordings Be Mandated in Dental Schools? Two Viewpoints: Viewpoint 1: Lecture Recordings Should Be Mandatory in U.S. Dental Schools and Viewpoint 2: Lecture Recordings Should Not Be Mandatory in U.S. Dental Schools.

Science.gov (United States)

Zandona, Andrea Ferreira; Kinney, Janet; Seong, WookJin; Kumar, Vandana; Bendayan, Alexander; Hewlett, Edmond

2016-12-01

Transcription or recording of lectures has been in use for many years, and with the availability of high-fidelity recording, the practice is now ubiquitous in higher education. Since technology has permeated education and today's tech-savvy students have expectations for on-demand learning, dental schools are motivated to record lectures, albeit with positive and negative implications. This Point/Counterpoint article addresses the question of whether lecture recording should be mandatory in U.S. dental schools. Viewpoint 1 supports the statement that lecture recording should be mandatory. Proponents of this viewpoint argue that the benefits-notably, student satisfaction and potential for improvement in student performance-outweigh concerns. Viewpoint 2 takes the opposite position, arguing that lecture recording decreases students' classroom attendance and adversely affects the morale of educators. Additional arguments against mandatory lecture recordings involve the expense of incorporating technology that requires ongoing support.

Taxonomy of Lecture Note-Taking Skills and Subskills

Science.gov (United States)

Al-Musalli, Alaa M.

2015-01-01

Note taking (NT) in lectures is as active a skill as listening, which stimulates it, and as challenging as writing, which is the end product. Literature on lecture NT misses an integration of the processes involved in listening with those in NT. In this article, a taxonomy is proposed of lecture NT skills and subskills based on a similar list…

Using lecture capture: a qualitative study of nursing faculty's experience.

Science.gov (United States)

Freed, Patricia E; Bertram, Julie E; McLaughlin, Dorcas E

2014-04-01

As lecture capture technology becomes widely available in schools of nursing, faculty will need to master new technological skills and make decisions about recording their classroom lectures or other activities. This study sought to understand faculty's experience of using a new lecture capture system. This qualitative study used Kruger's systematic approach to explore undergraduate nursing faculty's first-time experience using a lecture capture system purchased by the university. Four focus groups were conducted with a total of fourteen undergraduate faculty using lecture capture for the first-time. The interviews were recorded and transcribed and then analyzed by the researchers. Four themes were identified from the faculty interviews. Two of the themes expressed faculty's concerns about the teaching role, and two themes expressed the faculty's concerns about student learning. Participants experienced stress when learning to use the new lecture capture technology and struggled to resolve it with their own beliefs and teaching values. The impact of lecture capture on student learning, impact on class attendance, and the promotion of a culture of lecturing were revealed as important issues to consider when lecture capture becomes available. © 2013.

CB2 cannabinoid receptors modulate HIF-1α and TIM-3 expression in a hypoxia-ischemia mouse model.

Science.gov (United States)

Kossatz, Elk; Maldonado, Rafael; Robledo, Patricia

2016-12-01

The role of CB2 cannabinoid receptors (CB 2 R) in global brain lesions induced by hypoxia-ischemia (HI) insult is still unresolved. The aim of this study was to evaluate the involvement of CB 2 R in the behavioural and biochemical underpinnings related to brain damage induced by HI in adult mice, and the mechanisms involved. CB 2 R knockout (KO) mice and wild-type littermates (WT) underwent permanent ligation of the left common carotid artery and hypoxia. Behavioural measurements in the rotarod, beam walking, object recognition, open field, and Irwin tests were carried out 24h, 72h and 7 days. In KO mice, more extensive brain injury was observed. Behavioural deficits in the Irwin test were observed in both genotypes; while WT mice showed progressive recovery by day 7, KO mice did not. Only KO mice showed alterations in motor learning, coordination and balance, and did not recover over time. A higher expression of microglia and astrocytes was observed in several brain areas of lesioned WT and KO mice. The possible alteration of the inflammatory-related factors HIF-1α and TIM-3 was evaluated in these animals. In both genotypes, HIF-1α and TIM-3 expression was observed in lesioned areas associated with activated microglia. However, the expression levels of these proteins were exacerbated in KO mice in several lesioned and non-lesioned brain structures. Our results indicate that CB 2 R may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1α/TIM-3 signalling pathway in microglia. Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

ACADEMIC TRAINING LECTURE

CERN Multimedia

Academic Training; Tel. 73127

2001-01-01

23, 24, 25, 26 and 27 April REGULAR LECTURE PROGRAMME From 11:00 hrs - Main Auditorium bldg. 500, on 23 April from 11:15 to 12:15 hrs Searches for Dark Matter F. Feinstein / CPPM, Marseille, F The fact that the mass of the visible stars could not account for the gravitational cohesion of the galaxy clusters was the first manifestation of non-radiating matter in the Universe. Since then, many observations imply that most of the matter is indeed dark. Its nature is still unknown and likely to have several contributions. Recent results indicate that most of it may not be composed of normal matter. These lectures will review the experimental methods, which have been developed to unravel this 70-year long mystery and confront their results with the current theoretical framework of cosmology.

Academic Training: Summer Student Lecture Programme

CERN Multimedia

2004-01-01

Main Auditorium, bldg. 500 DATE TIME LECTURER TITLE Monday 26 July 09:15 - 10:00 A. Pich (IFIC) The Standard Model (7/8) 10:15 - 11:00 R. Rattazzi (CERN) Beyond the Standard Model (1/3) 11:15 - 12:00 K. Jacobs (Universität Freiburg) Physics in Hadronic Colliders (1/4) DATE TIME LECTURER TITLE Tuesday 27 July 09:15 - 10:00 A. Pich (IFIC) The Standard Model (8/8) 10:15 - 11:00 R. Rattazzi (CERN) Beyond the Standard Model (2/3) 11:15 - 12:00 R. Rattazzi (CERN) A. Pich (IFIC) Discussion Session DATE TIME LECTURER TITLE Wednesday 28 July 09:15 - 10:00 K. Jacobs (Universität Freiburg) Physics in Hadronic Colliders (2/4) 10:15 - 11:00 K. Jacobs (Universität Freiburg) Physics in Hadronic Colliders (3/4) 11:15 - 12:00 R. Rattazzi (CERN) Beyond the Standard Model (3/3) 14:00 - 15:00 R. Assmann (CERN) The CLIC project DATE TIME LECTURER TITLE Thursday 29 July 09:15 - 10:00 K. Jacobs (Universität Freiburg) Physics in Hadronic ...

On the Use of 233U-236U Double-Spike for TIMS Measurements of Uranium Isotopes: A Simulation Study

International Nuclear Information System (INIS)

Williams, R W

2004-01-01

Synthetic ion beams with instantaneous and temporal characteristics appropriate to thermal ionization mass spectrometry (TIMS) were mathematically generated and analyzed to determine the effects of using a mixed 233 U- 236 U spike (double-spike) in the analysis of uranium isotopes. The instantaneous beam characteristics are the intensities (e.g., counts per second) modeled with a Poisson distribution plus a component of random noise that simulates the detection processes. Several beam intensity and mass fractionation vs. time functions were modeled to simulate a range of sample sizes and the commonly employed methods of data collection. These beam profiles were also generated with different noise levels, and signal-to-noise vs. analytical precision diagrams are presented. Modeling focused on natural uranium, where 238 U/ 235 U = 137.88, and on the ability of a given method to determine precisely and accurately small variations in this ratio. Practical limits on precision were determined to be 20-30 ppm, which is consistent with precision seen for other elements by state-of-the-art TIMS. The TIMS total evaporation method was compared directly with the double-spike method. While similar analytical precisions are obtained with either method, the double-spike method of correcting for analytical bias gives more accurate results. The results of a total evaporation analysis will deviate from true by more than the analytical precision if as little as 0.05% of the signal is not integrated, whereas the accuracy and precision of the double-spiked analyses are always linked

11th June 2009-Cyprus-Minister of Education and Culture H. E. Prof. Andreas Demetriou

CERN Multimedia

Maximilien Brice

2009-01-01

Tirage 1 :CERN Director-General, R. Heuer and Minister of Education and Culture, H. E. Prof. Andreas Demetriou; Tirage 2:Council President,T. Åkesson, Ecole Normale Supérieure,K. Kounnas, Chairman of the Cyprus CERN Committee,C. N. Papanicolas, R. Heuer,A. Demetriou, Permanent Representative of the Republic of Cyprus in Geneva,A. Hadjichrysanthou, Directorate Office,E. Tsesmelis

Modeling of the time sharing for lecturers

Directory of Open Access Journals (Sweden)

E. Yu. Shakhova

2017-01-01

Full Text Available In the context of modernization of the Russian system of higher education, it is necessary to analyze the working time of the university lecturers, taking into account both basic job functions as the university lecturer, and others.The mathematical problem is presented for the optimal working time planning for the university lecturers. The review of the documents, native and foreign works on the study is made. Simulation conditions, based on analysis of the subject area, are defined. Models of optimal working time sharing of the university lecturers («the second half of the day» are developed and implemented in the system MathCAD. Optimal solutions have been obtained.Three problems have been solved:1 to find the optimal time sharing for «the second half of the day» in a certain position of the university lecturer;2 to find the optimal time sharing for «the second half of the day» for all positions of the university lecturers in view of the established model of the academic load differentiation;3 to find the volume value of the non-standardized part of time work in the department for the academic year, taking into account: the established model of an academic load differentiation, distribution of the Faculty number for the positions and the optimal time sharing «the second half of the day» for the university lecturers of the department.Examples are given of the analysis results. The practical application of the research: the developed models can be used when planning the working time of an individual professor in the preparation of the work plan of the university department for the academic year, as well as to conduct a comprehensive analysis of the administrative decisions in the development of local university regulations.

Professionalism of Lecturers at Faculty of Education

Science.gov (United States)

Tangkere, T. F. S.; Langitan, F. W.; Maukar, S. M. D.; Roring, R. F.

2018-02-01

The main objective of this research was to get the picture pertaining to the professionalization of Lecturers at Faculty of Education in Manado State University, Indonesia. The research method was naturalistic inquiry with qualitative approach. The research techniques were: deep interview, participative observation and document study. The data were analyzed by: data reduction, data display and conclusions, while the validation of data was done by four criteria, namely: credibility, transferability, dependability and conformability. The collecting procedure and data recording were done through observation and interviews. From the findings and conclusions, it can be identified that professionalization of Lecturers at Faculty of Education in Manado State University has been well processed. This can be proved by fulfillment of the minimum academic standard Ninety-one out of the total l12 lecturers has been certified. Based on conclusions, the researcher recommends that the teacher always develop their capability through increasing their academic qualification, self-development through attending educational trainings, conducting more research and publishing those researches through accredited journals. Dean of every Faculty and also execute supporting activities which will support self-development of the lectures and increase the budget for research of the lecturers.

text22.html | chandajog | 73am talks | annmeet | meetings | Indian ...

Indian Academy of Sciences (India)

ACADEMY PUBLIC LECTURE: Animal Sex Determination by Genes, Chromosomes and Environment. Posted on 12th March 2018. SPEAKER: Prof. Jennifer A Marshal Graves. VENUE: Faculty Hall, Indian Institute of Science. 13 March 2018 ǀ 1600. Event poster ...

A comparative study of traditional lecture methods and interactive lecture methods in introductory geology courses for non-science majors at the college level

Science.gov (United States)

Hundley, Stacey A.

In recent years there has been a national call for reform in undergraduate science education. The goal of this reform movement in science education is to develop ways to improve undergraduate student learning with an emphasis on developing more effective teaching practices. Introductory science courses at the college level are generally taught using a traditional lecture format. Recent studies have shown incorporating active learning strategies within the traditional lecture classroom has positive effects on student outcomes. This study focuses on incorporating interactive teaching methods into the traditional lecture classroom to enhance student learning for non-science majors enrolled in introductory geology courses at a private university. Students' experience and instructional preferences regarding introductory geology courses were identified from survey data analysis. The information gained from responses to the questionnaire was utilized to develop an interactive lecture introductory geology course for non-science majors. Student outcomes were examined in introductory geology courses based on two teaching methods: interactive lecture and traditional lecture. There were no significant statistical differences between the groups based on the student outcomes and teaching methods. Incorporating interactive lecture methods did not statistically improve student outcomes when compared to traditional lecture teaching methods. However, the responses to the survey revealed students have a preference for introductory geology courses taught with lecture and instructor-led discussions and students prefer to work independently or in small groups. The results of this study are useful to individuals who teach introductory geology courses and individuals who teach introductory science courses for non-science majors at the college level.

Changes in Editorial board Rhinology, Prof. Valerie Lund demits office as Editor in Chief of Rhinology

NARCIS (Netherlands)

Fokkens, W. J.

2014-01-01

At the Editorial Board Meeting of Rhinology Valerie Lund indicated that she has decided to emit office as Editor in Chief of Rhinology. She became a member of the editorial board in 1993, a co-editor with Prof. Bert Huizing in 1999 and Editor in Chief in 2004. She leaves with our grateful thanks for

Lecture on Female Masturbation Harassed Him, Male Student Says.

Science.gov (United States)

Wilson, Robin

1995-01-01

A male student in a California State University-Sacramento psychology lecture on female masturbation has filed a sexual harassment complaint, claiming the lecture violated institutional policy by creating an intimidating, hostile, and offensive learning environment. He felt the lecture was inappropriately graphic and political in intent. (MSE)

Making of Evalution’s Information System of Lecturer's Lecture and Major’s Service-Based Web in PTIK Major FKIP UNS

Directory of Open Access Journals (Sweden)

Irma Nuur Rochmah

2017-12-01

Full Text Available The quality of education of a study program can be measured from the level of customer satisfaction with the existing service. In accordance with ISO 9001: 2008, an organization should measure and obtain information related to customers and customers. Measurements and information that can be done survey data on customer satisfaction. From this survey data, Informatics and Computer Education Study Program can follow which aspect need improvement for program quality. One way to get survey data by doing the evaluation. In the Study Program of Informatics and Computer Engineering, evaluation using application form online form. The study program does not yet have its own evaluation information system. Therefore, the purpose of this research is to produce information technology and pelaynaan web-based program in the Study Program (Prodi Educational Engineering and Computer Informatics and to determine the level of the feasibility of information. In this study used research and development model with the first phase of the preliminary study, the second stage of product development and the last stage. At the product development stage is done by using software development model. From the stages of inputs obtained from the assessment of students on lecturers' lectures and prodi services in Education Program Informatics and Computer Engineering. The result of evaluation of lecturers' lectures and prodi services by selected students with their rena as output that can be seen by lecturer and admin. A system that can be used to help the services that have been given to the students, both in lecturers' lectures and prodi services. The results of this study, first, has created information and web-based programming services in Informatics and Computer Engineering Education Program, FKIP, UNS. Second, the feasibility of information and product and service development, Informatics and Computer Engineering Education Study Program, FKIP, UNS conducted by expert

Lectures on strings and dualities

International Nuclear Information System (INIS)

Vafa, C.

1997-01-01

In this set of lectures I review recent developments in string theory emphasizing their non-perturbative aspects and their recently discovered duality symmetries. The goal of the lectures is to make the recent exciting developments in string theory accessible to those with no previous background in string theory who wish to join the research effort in this area. Topics covered include a brief review of string theory, its compactifications, solitons and D-branes, black hole entropy and wed of string dualities. (author)

Jubilee Lecture

Indian Academy of Sciences (India)

2017-08-07

Aug 7, 2017 ... E up V As a \\ Nipio with students, teachers and researchers in India. Nsp1 Nup8C Nup57. Nup57. Nup145N. High tea will be served after the lecture. For details contact: M. Ananth, Molecular Biophysics Unit, Indian Institute of Science. Email: ananthmuthiah Ogmail.com/ananthmOmbu..iscernet.in Mob. 984 ...

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.

Science.gov (United States)

Linedale, Richard; Schmidt, Campbell; King, Brigid T; Ganko, Annabelle G; Simpson, Fiona; Panizza, Benedict J; Leggatt, Graham R

2017-01-01

Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Immunohistochemistry studies suggest that perineural tumour contains a lymphocyte infiltrate but it is difficult to quantitate the different proportions of immune cell subsets and expression of checkpoint molecules such as PD-1, Tim-3 and CTLA-4. Using flow cytometry of excised perineural tumour tissue, we show that a T cell infiltrate is prominent in addition to less frequent B cell, NK cell and NKT cell infiltrates. CD8 T cells are more frequent than other T cells in the tumour tissue. Amongst CD8 T cells, the frequency of Tim-3, CTLA-4 and PD-1 expressing cells was significantly greater in the tumour relative to the blood, a pattern that was repeated for Tim-3, CTLA-4 and PD-1 amongst non-CD8 T cells. Using immunohistochemistry, PD-1 and PD-L1-expression could be detected in close proximity amongst perineural tumour tissue. The data suggest that perineural SCC contains a mixture of immune cells with a predominant T cell infiltrate containing CD8 T cells. Elevated frequencies of tumour-associated Tim-3+, CTLA-4+ and PD-1+ CD8 T cells suggests that a subset of patients may benefit from local antibody blockade of these checkpoint inhibitors.

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.

Directory of Open Access Journals (Sweden)

Richard Linedale

Full Text Available Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Immunohistochemistry studies suggest that perineural tumour contains a lymphocyte infiltrate but it is difficult to quantitate the different proportions of immune cell subsets and expression of checkpoint molecules such as PD-1, Tim-3 and CTLA-4. Using flow cytometry of excised perineural tumour tissue, we show that a T cell infiltrate is prominent in addition to less frequent B cell, NK cell and NKT cell infiltrates. CD8 T cells are more frequent than other T cells in the tumour tissue. Amongst CD8 T cells, the frequency of Tim-3, CTLA-4 and PD-1 expressing cells was significantly greater in the tumour relative to the blood, a pattern that was repeated for Tim-3, CTLA-4 and PD-1 amongst non-CD8 T cells. Using immunohistochemistry, PD-1 and PD-L1-expression could be detected in close proximity amongst perineural tumour tissue. The data suggest that perineural SCC contains a mixture of immune cells with a predominant T cell infiltrate containing CD8 T cells. Elevated frequencies of tumour-associated Tim-3+, CTLA-4+ and PD-1+ CD8 T cells suggests that a subset of patients may benefit from local antibody blockade of these checkpoint inhibitors.

45 CFR 73.735-706 - Teaching, lecturing, and speechmaking.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Teaching, lecturing, and speechmaking. 73.735-706... OF CONDUCT Outside Activities § 73.735-706 Teaching, lecturing, and speechmaking. (a) Employees are encouraged to engage in teaching and lecturing activities which are not part of their official duties when...

Features of using multimedia technologies at lecturing programming

Directory of Open Access Journals (Sweden)

G. S. Ivanova

2014-01-01

Full Text Available The subject of study of this paper is multimedia capabilities, which are used for lectures on programming for undergraduate students to learn Computer Science and Engineering.The objective is to analyze the factors affecting the efficiency of lectures on programming, readable using multimedia, identifying the advantages and disadvantages of using presentations and process of creating and debugging programs in software environments demonstration, and to make recommendations on the use of illustrative material aimed at improving student's handout with the knowledge readable material.Scientific novelty of the material is to identify and analyze the factors influencing the effectiveness of teaching programming using multimedia as well as to make recommendations on the creation of illustrative material in the form of lecture presentations, analyse the negative side effects of presentations and opportunities to address them.It is stated that even at the initial stage of teaching in programming the amount of learning material and associated details in their records to which student's attention should be drawn, commensurate with the restrictions of psycho physiological capabilities defined for modern undergraduate students to remember and learn. The conclusion about expediency to improve lectures efficiency through the use of multimedia equipment capabilities is made.The types of illustrative material used in lectures on programming are listed and named, examples of illustrative material for presentation slides are analyzed. The positive results of the process of program creating, debugging and running directly in the programming environment during the lecture are underlined .As the merits of the multimedia-based lectures are marked a significant reduction of time to be required for material presentation ( from 10 to 30 % and the structured and with no errors in the program texts of lectures available for students. Negative effects of the multimedia

Coordinated Traffic Incident and Congestion Management (TIM-CM) : Mitigating Regional Impacts of Major Traffic Incidents in the Seattle I-5 Corridor

Science.gov (United States)

2018-02-02

Within the Seattle metropolitan area, traffic incident management (TIM) operations provide a multi-jurisdictional and coordinated strategy to detect, respond to, and clear traffic incidents so that traffic flow can be restored quickly and safely. The...

Academic Training: Summer Student Lecture Programme

CERN Multimedia

2004-01-01

Main Auditorium, bldg. 500 DATE TIME LECTURER TITLE Monday 19 July 09:15 - 10:00 A. PICH (IFIC) The Standard Model (1/8) 10:15 - 11:00 O. ULLALAND (CERN) Detectors (2/5) 11:15 - 12:00 O. ULLALAND (CERN) Detectors (3/5) DATE TIME LECTURER TITLE Tuesday 20 July 09:15 - 10:00 A. PICH (IFIC) The Standard Model (2/8) 10:15 - 11:00 O. ULLALAND (CERN) Detectors (4/5) 11:15 - 12:00 O. ULLALAND (CERN) A. PICH (IFIC) Discussion Session DATE TIME LECTURER TITLE Wednesday 21 July 09:15 - 10:00 A. PICH (IFIC) The Standard Model (3/8) 10:15 - 11:00 A. PICH (IFIC) The Standard Model (4/8) 11:15 - 12:00 O. ULLALAND (CERN) Detectors (5/5) 14:00 - 15:00 R. BRUN (CERN) ROOT: Introduction and Demonstration DATE TIME LECTURER TITLE Thursday 22 July 09:15 - 10:00 A. PICH (IFIC) The Standard Model (5/8) 10:15 - 11:00 C. De La Taille (Laboratoire de l'Accélérateur Linéaire) Introduction to Electronics (1/3) 11:15 - 12:00 A. PICH (IFIC) C. De La Taille (Laboratoi...

Reaktortagung Duesseldorf

International Nuclear Information System (INIS)

Anon.

1976-01-01

Report on the Reaktortagung 1976 in Duesseldorf, in particular on the lectures on the subject of energy economy and ensuring waste management by the undersecretary of state Schmude and Prof. Mandel on the occasion of the festive proceedings. (RW/LN) [de

Dr TIM: Ray-tracer TIM, with additional specialist scientific capabilities

Science.gov (United States)

Oxburgh, Stephen; Tyc, Tomáš; Courtial, Johannes

2014-03-01

We describe several extensions to TIM, a raytracing program for ray-optics research. These include relativistic raytracing; simulation of the external appearance of Eaton lenses, Luneburg lenses and generalised focusing gradient-index lens (GGRIN) lenses, which are types of perfect imaging devices; raytracing through interfaces between spaces with different optical metrics; and refraction with generalised confocal lenslet arrays, which are particularly versatile METATOYs. Catalogue identifier: AEKY_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKY_v2_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licencing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 106905 No. of bytes in distributed program, including test data, etc.: 6327715 Distribution format: tar.gz Programming language: Java. Computer: Any computer capable of running the Java Virtual Machine (JVM) 1.6. Operating system: Any, developed under Mac OS X Version 10.6 and 10.8.3. RAM: Typically 130 MB (interactive version running under Mac OS X Version 10.8.3) Classification: 14, 18. Catalogue identifier of previous version: AEKY_v1_0 Journal reference of previous version: Comput. Phys. Comm. 183(2012)711 External routines: JAMA [1] (source code included) Does the new version supersede the previous version?: Yes Nature of problem: Visualisation of scenes that include scene objects that create wave-optically forbidden light-ray fields. Solution method: Ray tracing. Reasons for new version: Significant extension of the capabilities (see Summary of revisions), as demanded by our research. Summary of revisions: Added capabilities include the simulation of different types of camera moving at relativistic speeds relative to the scene; visualisation of the external appearance of generalised focusing gradient-index (GGRIN) lenses, including Maxwell fisheye, Eaton and Luneburg lenses; calculation of

"But They Won't Come to Lectures..." The Impact of Audio Recorded Lectures on Student Experience and Attendance

Science.gov (United States)

Larkin, Helen E.

2010-01-01

The move to increasingly flexible platforms for student learning and experience through provision of online lecture recordings is often interpreted by educators as students viewing attendance at lectures as optional. The trend toward the use of this technology is often met with resistance from some academic staff who argue that student attendance…

Students' Perception of Live Lectures' Inherent Disadvantages

Science.gov (United States)

Petrovic, Juraj; Pale, Predrag

2015-01-01

This paper aims to provide insight into various properties of live lectures from the perspective of sophomore engineering students. In an anonymous online survey conducted at the Faculty of Electrical Engineering and Computing, University of Zagreb, we investigated students' opinions regarding lecture attendance, inherent disadvantages of live…

Enhancing the Lecture: Revitalizing the Traditional Format.

Science.gov (United States)

Bonwell, Charles C.

1996-01-01

The traditional lecture format of college courses can be enhanced by including active learning designed to further course goals of learning knowledge, developing skills, or fostering attitudes. Techniques suggested include using pauses, short writing periods, think-pair-share activities, formative quizzes, lecture summaries, and several assessment…

The Use of Blog as Supporting Media for Competence of Lecturer

Directory of Open Access Journals (Sweden)

Anne Ratnasari

2015-12-01

Full Text Available Competence is one of the important parts of brand study, while brand it is a part of the marketing that has an important position by selling product and services. So brand itself not only for the company, it can also manage individual brands, public figures, and lecturer. This research aimed for determining the use of blogs as a medium to support the competence of lecturers from the aspect trustworthiness, commitment, ability to develop themselves practicing a profession, and a limiting factor in building the competence of lecturers. This research uses a qualitative approach with a single case study through observation, interviews, focus group discussions, and literature. The study found that lecturer use blogs to share lectures, ideas about contemporary events, and upload Islamic articles. Lecturer assessed reliably, because the lecturer writing on a blog is the result of his work, and a lot of consultation requests from various circles. The lecturer is committed to making a change for the better in every way when communicating via blog to maintain conformity with the words of his behavior, and lecturer has the ability to develop themselves in their profession as a lecturer, that gives him the strength to continue working.

Prof. dr Zvonimir Dévidé (prigodom 65. godišnjice života)

OpenAIRE

Papeš, Dražena; Jelaska, Sibila

1986-01-01

Zvonimir Dévidé, Ph. D. habil., Professor of cell biology and plant physiology at the Faculty of Natural Sciences and Mathematics of the University of Zagreb, was born on 6.8.1921 in Lenart, Slovenske Gorice (North-eastern Slovenia). Having completed his studies at the Philosophical Faculty in Zagreb and in Vienna (where his academic advisor was prof. dr. Lothar Geitler) he started to work in 1948 as asistant in the Botanic Institute of the Faculty of Natural Sciences and Mathematics of the U...

Recently Published Lectures and Tutorials for ATLAS

CERN Multimedia

J. Herr

2006-01-01

As reported in the September 2004 ATLAS eNews, the Web Lecture Archive Project, a collaboration between the University of Michigan and CERN, has developed a synchronized system for recording and publishing educational multimedia presentations, using the Web as medium. The current system, including future developments for the project and the field in general, was recently presented at the CHEP 2006 conference in Mumbai, India. The relevant presentations and papers can be found here: The Web Lecture Archive Project A Web Lecture Capture System with Robotic Speaker Tracking This year, the University of Michigan team has been asked to record and publish all ATLAS Plenary sessions, as well as a large number of Physics and Computing tutorials. A significant amount of this material has already been published and can be accessed via the links below. All lectures can be viewed on any major platform with any common internet browser, either via streaming or local download (for limited bandwidth). Please enjoy the l...

Recently Published Lectures and Tutorials for ATLAS

CERN Multimedia

Goldfarb, S.

2006-01-01

As reported in the September 2004 ATLAS eNews, the Web Lecture Archive Project, WLAP, a collaboration between the University of Michigan and CERN, has developed a synchronized system for recording and publishing educational multimedia presentations, using the Web as medium. The current system, including future developments for the project and the field in general, was recently presented at the CHEP 2006 conference in Mumbai, India. The relevant presentations and papers can be found here: The Web Lecture Archive Project. A Web Lecture Capture System with Robotic Speaker Tracking This year, the University of Michigan team has been asked to record and publish all ATLAS Plenary sessions, as well as a large number of Physics and Computing tutorials. A significant amount of this material has already been published and can be accessed via the links below. All lectures can be viewed on any major platform with any common internet browser, either via streaming or local download (for limited bandwidth). Please e...

Dynamic e-learning modules for student lecture preparation

Directory of Open Access Journals (Sweden)

Timothy McIntyre

2018-03-01

Full Text Available We have developed and demonstrated the effectiveness of a set of online interactive learning modules to accompany physics courses at first- and second-year university levels. Students access the modules prior to attending lectures to familiarize themselves with content which is then discussed and reaffirmed in class. Student surveys and access data show that students were much more likely to use material presented in this form, rather than a textbook, when preparing for lectures given in an active learning format. The students found that interactive simulations, videos of problem-solving approaches prepared by course staff, and quick-check immediate feedback questions were all useful tools for lecture preparation–none of which are available when using a traditional textbook for lecture preparation.