Selected DOE Headquarters publications, October 1979-

Energy Technology Data Exchange (ETDEWEB)

None

1980-11-01

This publication provides a cumulative listing of and an index to DOE headquarters publications issued since October 1979. (Publications issued during October 1977 to September 1979 are covered in DOE/AD-0010/6.) Three types of headquarters publications are included: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations, reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department, and environmental development plans, environmental impact statements, and environmental readiness documents. Certain publications have been omitted. They include such items as pamphlets, fact sheets, bulletins, newsletters, and telephone directories. Also omitted are weekly/monthly reports of the Energy Information Administration and headquarters publications issued under the DOE-tr and CONF codes. (RWR)

DOE headquarters publications

International Nuclear Information System (INIS)

1978-12-01

This bibliography provides listings of (mainly policy and programmatic) publications issued from the U.S. Department of Energy, Washington, D.C. The listings are arranged by the report number assigned to each publication. All of the publications listed, except for those shown as still in preparation, may be seen in the Energy Library. A title index arranged by title keywords follows the listings. Certain publications have been omitted. They include such items as pamphlets, fact sheets, bulletins and weekly/monthly issuances of DOE's Energy Information Administration and Economic Regulatory Administration, and employee bulletins and newsletters. Omitted from the bibliography altogether are headquarters publications assigned other types of report codes--e.g., HCP (Headquarters Contractor Publication) and CONF

Legitimacy Dynamics in Headquarters-Subsidiary Relationships

DEFF Research Database (Denmark)

Gammelgaard, Jens; Kumar, Rajesh

The relationship between multinational enterprises’ (MNE) headquarters and their subsidiaries has been of considerable interest to international business scholars (e.g., Dörrenbächer and Geppert, 2009). Although a subsidiary is an integral part of an MNE, its interests do not necessarily converge...... with those of headquarters. Many scholars note that relationships between headquarters and subsidiaries are characterized by the simultaneous presence of cooperation and competition (e.g., Bouquet and Birkinshaw, 2008; Otterbeck, 1981). On the one hand, the subsidiary and its managers are dependent...... on headquarters’ resources to fulfill its mandate. On the other hand, the subsidiary and its managers have their own particular goals, which may or may not coincide with the goals of headquarters and its managers. Subsidiary managers may also seek to develop the unit’s own sense of identity, which may...

Selected DOE Headquarters Publications, October 1979

Energy Technology Data Exchange (ETDEWEB)

None

1980-09-01

This publication provides cumulative listings of and an index to DOE headquarters publications issued since October 1979. (Publications issued during October 1977-September 1979 are covered in DOE/AD-0010/6.) Three types of headquarters publications are included: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations, reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department, and environmental development plans and impact statements. Certain publications have been omitted. They include such items as pamphlets, fact sheets, bulletins, newsletters, and telephone directories, headquarters publications issued under the DOE-tr and CONF codes, technical reports from the Jet Propulsion Laboratory and NASA issued under DOE/JPL and DOE/NASA codes, and weekly/monthly reports of the Energy Information Administration. (RWR)

39 CFR 221.5 - Headquarters organization.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Headquarters organization. 221.5 Section 221.5 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION GENERAL ORGANIZATION § 221.5 Headquarters organization. (a) Postmaster General—(1) Appointment. The postmaster general (PMG), the chief...

Selected DOE headquarters publications, October 1979

International Nuclear Information System (INIS)

1981-01-01

The publication provides cumulative listings of and an index to DOE headquarters publications issued since October 1979. Publications issued during October 1977 to September 1979 are covered in DOE/AD-0010/6. Publications from 26 headquarters offices are presented and consist of three types: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations; reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department under 01-type contracts; and environmental development plans, impact statements, and readiness documents. Availability of the documents is described

Selected DOE headquarters publications, October 1979

Energy Technology Data Exchange (ETDEWEB)

None

1981-01-01

The publication provides cumulative listings of and an index to DOE headquarters publications issued since October 1979. Publications issued during October 1977 to September 1979 are covered in DOE/AD-0010/6. Publications from 26 headquarters offices are presented and consist of three types: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations; reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department under 01-type contracts; and environmental development plans, impact statements, and readiness documents. Availability of the documents is described.

39 CFR 268.1 - General principles.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false General principles. 268.1 Section 268.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION-EMPLOYEE RULES OF CONDUCT § 268.1 General principles. In order to conduct its business, the Postal Service has the...

12 CFR 268.105 - Individual complaints.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Individual complaints. 268.105 Section 268.105... RULES REGARDING EQUAL OPPORTUNITY Board Program To Promote Equal Opportunity § 268.105 Individual... individual and the Board and to describe generally the action(s) or practice(s) that form the basis of the...

Longview District Operations and Maintenance Headquarters: Environmental assessment

International Nuclear Information System (INIS)

1992-03-01

Bonneville Power Administration (BPA) operations and maintenance staff are presently based at a headquarters next to the Longview Substation. These headquarters buildings, however, were built in 1941 and have deteriorated to the point of needing extensive repair. They also lack sufficient inside storage space. New buildings cannot be constructed on the site because of surrounding development. In addition, the site is within an area exposed to industrial fallout (coal tar pitch and metallic particles) that may be damaging buildings, equipment, and vehicles. BPA is concerned about the potential health risk to headquarters staff from the fallout. In light of these problems, BPA proposes to construct a new operations and maintenance headquarters at a different location, and to demolish the existing headquarters. This paper discusses the environmental impacts of the proposed action and alternatives

Headquarters Vienna

International Nuclear Information System (INIS)

1985-01-01

This film presents the IAEA safeguards system showing six inspectors at their work in the nuclear power plants Kozloduy (Bulgaria), Mihama (Japan) as well as in the reprocessing plant La Hague (France). The results of inspections are checked at the IAEA Headquarters in Vienna. The film shows all modern techniques applied in the IAEA safeguards system

Headquarters Vienna

Energy Technology Data Exchange (ETDEWEB)

NONE

1986-12-31

This film presents the IAEA safeguards system showing six inspectors at their work in the nuclear power plants Kozloduy (Bulgaria), Mihama (Japan) as well as in the reprocessing plant La Hague (France). The results of inspections are checked at the IAEA Headquarters in Vienna. The film shows all modern techniques applied in the IAEA safeguards system

40 CFR 268.4 - Treatment surface impoundment exemption.

Science.gov (United States)

2010-07-01

... residues may not be placed in any other surface impoundment for subsequent management. (iv) Recordkeeping... exemption. 268.4 Section 268.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...), the residues from treatment are analyzed, as specified in § 268.7 or § 268.32, to determine if they...

Stimulating Sustainability in Multinational Companies: the Significance of Regional Headquarters

Directory of Open Access Journals (Sweden)

Andreas G. M. NACHBAGAUER

2016-06-01

Full Text Available Recently, regional headquarters have gained practical importance and theoretical attention. Traditionally considered a mere transmission facility to manage complex organisations, advanced approaches, however, locate regional headquarters in a field of tension between hierarchical integration and strategic independence. Given the growing concern for global responsibility, stimulating sustainability also and particularly addresses regional headquarters. This conceptual article combines the call for sustainability with the upcoming importance of regional headquarters: which contributions can the regional headquarters of a multinational company deliver to stimulate the development of sustainable corporate strategy and operations? The main topics are the effects different versions of embedding regional headquarters into the corporate context have on opportunities to implement sustainability policies: Are there different chances for successful implementation depending on the strategic setup of the company? Does the distribution of competences matter? Which types of interaction between headquarters and branch are suitable to introduce sustainability sustainably? Is the mix of national contexts of headquarters and branch of importance? First results show that depending on the companywide strategy, and especially on the structure and distribution of competences, regional headquarters can play a significant role as trigger of sustainability. The literature favours strong involvement and large autonomy of both branches as well as regional headquarters for the development and management of sustainability. The parts of the company involved in a critical environment often are the starting point of sustainability policies.

12 CFR 268.202 - Equal Pay Act.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Equal Pay Act. 268.202 Section 268.202 Banks... REGARDING EQUAL OPPORTUNITY Provisions Applicable to Particular Complaints § 268.202 Equal Pay Act. Complaints alleging violations of the Equal Pay Act shall be processed under this part. ...

12 CFR 268.601 - EEO group statistics.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false EEO group statistics. 268.601 Section 268.601... RULES REGARDING EQUAL OPPORTUNITY Matters of General Applicability § 268.601 EEO group statistics. (a... solely statistical purpose for which the data is being collected, the need for accuracy, the Board's...

12 CFR 268.302 - Mixed case complaints.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Mixed case complaints. 268.302 Section 268.302... RULES REGARDING EQUAL OPPORTUNITY Related Processes § 268.302 Mixed case complaints. A mixed case... discrimination or it may contain additional allegations that the MSPB has jurisdiction to address. A mixed case...

How do Regional Headquarters Influence Corporate Decisions in Networked MNCs?

DEFF Research Database (Denmark)

Mahnke, Volker; Ambos, Björn; Nell, Phillip Christopher

2012-01-01

In networked MNCs where knowledge and power are distributed, corporate strategy processes benefit from input arising from many different levels of the organization. Recently, the regional (i.e., supra-national) level has been emphasized as an important additional source of knowledge and input......, and as a bridge between local subsidiaries and global corporate headquarters. This paper builds theory on the antecedents to regional headquarters' influence on corporate decisions (i.e., organizational, behavioral, and motivational). Based on a survey of regional headquarters in Europe and their relations...... with MNC headquarters, we provide empirical evidence that a regional headquarters' autonomy and signaling behavior have significant effects on its influence on corporate strategy. Furthermore, we find support for our hypothesis that the regional headquarters' charter moderates such bottom–up influence....

American Red Cross Headquarters

Data.gov (United States)

Department of Homeland Security — This point file represents only the headquarters location for each chapter and does not reflect any branch offices or warehouse facilities. Due to the recent changes...

Fortune 500 Corporate Headquarters

Data.gov (United States)

Department of Homeland Security — Large Corporate Headquarters in the United States This database is composed of 'an annual list of the 500 largest industrial corporations in the U.S., published by...

Initial operations in local nuclear emergency response headquarter

International Nuclear Information System (INIS)

2012-06-01

As a result of the Fukushima nuclear accident due to the Great East Japan Earthquake and the tsunami that occurred thereafter, local nuclear emergency response headquarters (local headquarters) was set up at off-site center (OFC). However, several obstacles such as the collapse of means of communication resulting from severed communication lines, food and fuel shortage resulting from stagnant physical distribution, and increasing radiation dose around the center significantly restricted originally intended operation of local headquarters. In such severe situation, the personnel gathered at the OFC from the government, local public bodies and electric companies from March 11 to 15 acted without sufficient food, sleep or rest and did all they could against successively occurring unexpected challenges by using limited means of communication. However, issues requiring further consideration were activities of each functional group, location of OFC and the functions of equipment, machines and materials and reflecting the consideration results into future protective measures and revision of the manual for nuclear emergency response were greatly important. This report described investigated results on initial operations in local headquarters such as situation of activities conducted by local headquarters and operations at functional groups. (T. Tanaka)

12 CFR 268.710 - Compliance procedures.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Compliance procedures. 268.710 Section 268.710 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM... Women's Program Manager, the Hispanic Employment Program Coordinator, or the People with Disabilities...

Conflict Resolution in Headquarters-Subsidiary Relationships

DEFF Research Database (Denmark)

Kumar, Rajesh; Gammelgaard, Jens

2016-01-01

We demonstrate the role of regulatory fit and moral emotions, that is, contempt and anger, in influencing conflict resolution between the headquarters and subsidiary boundary spanners. We develop a theoretical framework, which integrates literature on international business and headquarters......-subsidiary relationships with regulatory focus, moral emotions, and conflict resolution. The chapter outlines the relationships between the regulatory focus of a headquarters’ boundary spanner, and his or her manner of engagement, conflict sensitivity, violation of code, moral emotions, and the way conflicts are resolved...

Behavioral experience induces zif268 expression in mature granule cells but suppresses its expression in immature granule cells

Directory of Open Access Journals (Sweden)

Kylie A. Huckleberry

2015-08-01

Full Text Available Thousands of neurons are born each day in the dentate gyrus (DG, but many of these cells die before reaching maturity. Both death and survival of adult-born neurons are regulated by neuronal activity in DG. The immediate-early gene (IEG zif268 is an important mediator of these effects, as its expression is induced by neural activity and knockout of zif268 impairs survival of adult-born neurons (Veyrac et al., 2013. Despite the apparent importance of zif268 for adult neurogenesis, its behavior-induced expression has not been fully characterized in adult-born neurons. Here we characterize behavior-evoked expression of zif268 in mature and newborn dentate granule cells (DGCs. In the general granule cell population, zif268 expression peaked 1 hour after novel environment exposure and returned to baseline by 8 hours post-exposure. However, in the doublecortin-positive (DCX+ immature neurons, zif268 expression was suppressed relative to home cage for at least 8 hours post-exposure. We next determined that exposure to water maze training, an enriched environment, or a novel environment caused approximately equal suppression of zif268 expression in DCX+ cells and approximately equal activation of zif268 in the general DGC population and in 6-week-old adult-born neurons. Finally, we asked whether zif268 suppression varied as a function of age within the DCX+ population, which ranges in age from 0 to approximately 4 weeks. Novel environment exposure had no significant effect on zif268 expression in 2- or 4-week-old BrdU-labeled neurons, but it significantly suppressed zif268 expression in 3-week-old neurons. In summary, behavioral experience transiently activated expression of zif268 in mature DGCs but caused a more long-lasting suppression of zif268 expression in immature, adult-born DGCs. We hypothesize that zif268 suppression inhibits memory-related synaptic plasticity in immature DGCs or mediates learning-induced apoptosis of immature adult

Selected DOE Headquarters publications, October 1977-September 1979

International Nuclear Information System (INIS)

1979-11-01

This sixth issue of cumulative listings of DOE Headquarters publications covers the first two years of the Department's operation (October 1, 1977 - September 30, 1979). It lists two groups of publications issued by then-existing Headquarters organizations and provides an index to their title keywords. The two groups of publications are publications assigned a DOE/XXX-type report number code and Headquarters contractor reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department. Certain publications are omitted. They include such items as pamphlets, fact sheets, bulletins, newsletters, and telephone directories, as well as headquarters publications issued under the DOE-tr (DOE translation) and CONF (conference proceedings) codes, and technical reports from the Jet Propulsion Laboratory and NASA issued under DOE/JPL and DOE/NASA codes. The contents of this issue will not be repeated in subsequent issues of DOE/AD-0010

Adult Learning Development in Poland in the 20th Century

Science.gov (United States)

Boiarska-Khomenko, Anna

2017-01-01

The article presents a retrospective analysis of adult learning development in Poland in the 20th century. Based on the study and analysis of historical and pedagogical literature, normative documents of the official bodies of Polish government, the periodical press of the 20th century, several stages of adult learning development, in the…

Conference report on Media and Learning Conference, Brussels, March 9th & 10th, 2016

NARCIS (Netherlands)

Zac Woolfitt

2016-01-01

On March 9th and 10th Zac Woolfitt attended the Media and Learning Conference in Brussels. The programme of this annual conference examines ‘developments, services and uses of media in education and training to […] identify policies and initiatives that promote digital and media competence at all

Behavioral experience induces zif268 expression in mature granule cells but suppresses its expression in immature granule cells

Science.gov (United States)

Huckleberry, Kylie A.; Kane, Gary A.; Mathis, Rita J.; Cook, Sarah G.; Clutton, Jonathan E.; Drew, Michael R.

2015-01-01

suppressed zif268 expression in 3-week-old neurons. In summary, behavioral experience transiently activated expression of zif268 in mature granule cells but caused a more long-lasting suppression of zif268 expression in immature, adult-born granule cells. We hypothesize that zif268 suppression inhibits memory-related synaptic plasticity in immature neurons or mediates learning-induced apoptosis of immature adult-born neurons. PMID:26347620

Selected DOE Headquarters publications, October 1977-September 1979

Energy Technology Data Exchange (ETDEWEB)

None

1979-11-01

This sixth issue of cumulative listings of DOE Headquarters publications covers the first two years of the Department's operation (October 1, 1977 - September 30, 1979). It lists two groups of publications issued by then-existing Headquarters organizations and provides an index to their title keywords. The two groups of publications are publications assigned a DOE/XXX-type report number code and Headquarters contractor reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department. Certain publications are omitted. They include such items as pamphlets, fact sheets, bulletins, newsletters, and telephone directories, as well as headquarters publications issued under the DOE-tr (DOE translation) and CONF (conference proceedings) codes, and technical reports from the Jet Propulsion Laboratory and NASA issued under DOE/JPL and DOE/NASA codes. The contents of this issue will not be repeated in subsequent issues of DOE/AD-0010. (RWR)

Stimulating Sustainability in Multinational Companies: the Significance of Regional Headquarters

OpenAIRE

Andreas G. M. NACHBAGAUER

2016-01-01

Recently, regional headquarters have gained practical importance and theoretical attention. Traditionally considered a mere transmission facility to manage complex organisations, advanced approaches, however, locate regional headquarters in a field of tension between hierarchical integration and strategic independence. Given the growing concern for global responsibility, stimulating sustainability also and particularly addresses regional headquarters. This conceptual article combines the call...

12 CFR 268.203 - Rehabilitation Act.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Rehabilitation Act. 268.203 Section 268.203... Rehabilitation Act. (a) Model employer. The Board shall be a model employer of individuals with disabilities. The... Rehabilitation Act of 1973, as amended (29 U.S.C. 791), has been violated in a complaint alleging nonaffirmative...

Selected DOE Headquarters publications received by the Energy Library

International Nuclear Information System (INIS)

1978-07-01

This bibliography provides listings of (mainly policy and programmatic) publications issued from the U.S. Department of Energy, Washington, D.C. The listings are arranged by the ''report code'' assigned to the major organizations at DOE Headquarters, followed by the three categories of environmental reports issued from DOE Headquarters. All of the publications listed, except for those shown as still ''in preparation,'' may be seen in the Energy Library. A title index arranged by title keywords follows the listings. Certain publications have been omitted. They include such items as pamphlets, ''fact sheets,'' bulletins and weekly/monthly issuances of DOE's Energy Information Administration and Economic Regulatory Administration, and employee bulletins and newsletters. Omitted from the bibliography altogether are headquarters publications assigned other types of report codes--e.g., ''HCP'' (Headquarters Contractor Publication) and ''CONF''

Are Large Headquarters Unproductive? Evidence from a Panel of Japanese Companies (Japanese)

OpenAIRE

MORIKAWA Masayuki

2014-01-01

This paper, using large panel data of Japanese companies (2001-2011), empirically analyzes the determinants of the size of headquarters and their effect on productivity. Headquarters functions, the core service sector within companies, play important roles in supporting strategic decision making in modern companies. However, it is often advocated that the downsizing of headquarters improves organizational efficiency. The size of headquarters is closely related to the issue of centralization/d...

A Contextualized Model of Headquarters-subsidiary Agency Problems

DEFF Research Database (Denmark)

Kostova, Tatiana; Nell, Phillip Christopher; Hoenen, Anne Kristin

This paper proposes an agency model for headquarters-subsidiary relationships in multinational organizations with headquarters as the principal and the subsidiary as the agent. As a departure from classical agency theory, our model is developed for the unit level of analysis and considers two root...... in which the headquarters-subsidiary dyad is embedded. We then discuss several agency scenarios that lead to different manifestations of the agency problem. The framework informs more relevant applications of agency theory in organizational studies and motivates future research....... causes of the agency problem – self-interest and bounded rationality. We argue that one cannot assume absolute self-interest and perfect rationality of agents but should allow them to vary. We explain subsidiary-level variation through a set of internal organizational and external social conditions...

Are Large Headquarters Unproductive? Evidence from a panel of Japanese companies

OpenAIRE

MORIKAWA Masayuki

2014-01-01

Headquarters play an important role in modern companies, but the downsizing of headquarters is often advocated as a way to improve organizational efficiency. The size of headquarters is closely related to the centralization/decentralization of decision making, and a theoretically optimal level of (de)centralization depends on various conditions. Using a panel of more than 40,000 Japanese companies for the period 2001-2011, this paper empirically analyzes the determinants of the size of headqu...

Headquarters Of APSCO Opens In Beijing

Institute of Scientific and Technical Information of China (English)

Xu Yansong

2009-01-01

@@ The headquarters of Asia-Pacific Space Cooperation Organization (APSCO) has been inaugurated in Beijing.APSCO is the biggest space organization in Asia. Established in 2008, the organization has 9 members in the Asia-Pacific region.

Location trends of large company headquarters during the 1990s

OpenAIRE

Thomas H. Klier; William A. Testa

2002-01-01

This article documents changes in the spatial distribution of corporate headquarters of large U.S.-domiciled corporations during the 1990s. The authors find that the largest metropolitan areas continue to host a disproportionate share of headquarters, but there have been significant shifts toward cities with population between one and two million.

19 CFR 172.12 - Petitions acted on at Customs Headquarters.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Petitions acted on at Customs Headquarters. 172.12 Section 172.12 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Petitions § 172.12 Petitions acted on at Customs Headquarters. Upon receipt of a petition for relief filed...

Iraqi Civil Defense Headquarters Baghdad, Iraq

National Research Council Canada - National Science Library

Johnston, Angelina; O'Connor, Kevin; Rawal, Yogin

2007-01-01

.... The assessment team included two engineers/inspectors and three auditors/inspectors. The overall objective of the project was to fully renovate the Civil Defense Headquarters and other buildings on the site to become a fully operational and usable facility.

40 CFR 268.49 - Alternative LDR treatment standards for contaminated soil.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Alternative LDR treatment standards for contaminated soil. 268.49 Section 268.49 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Treatment Standards § 268.49 Alternative LDR treatment standards for contaminated...

Modular Structures in a Multinational Force Headquarters

National Research Council Canada - National Science Library

Stewart, K; Christie, M

2004-01-01

.... It is proposed that future Multinational Force (MNF) military headquarters (HQ) can achieve this flexibility through a modular organizational structure enabled by networked information management and communication technologies...

The Size and Composition of Corporate Headquarters in Multinational Companies: Empirical Evidence

OpenAIRE

Collis, David J.; Young, David; Goold, Michael

2012-01-01

Based on a six-country survey of nearly 250 multinationals (MNCs), this paper is the first empirical analysis to describe the size and composition of MNC headquarters and to account for differences among them. Findings are as follows: MNC corporate headquarters are more involved in "obligatory" and value creating and control functions than in operational activities; there are no systematic differences in the determinants of the size and composition of corporate headquarters between MNCs and p...

39 CFR 223.2 - Channels of communication, headquarters with area offices.

Science.gov (United States)

2010-07-01

... RELATIONSHIPS AND COMMUNICATION CHANNELS § 223.2 Channels of communication, headquarters with area offices. (a... 39 Postal Service 1 2010-07-01 2010-07-01 false Channels of communication, headquarters with area...). Whether published on paper or online, such policies must be coordinated with other appropriate...

Headquarters-subsidiary relationship governance in Poland

NARCIS (Netherlands)

Gusc, J.S.; Omta, S.W.F.

2011-01-01

The study addresses the views of agency and stewardship theory on governance of the relationship between headquarters and subsidiaries. It explores the influence of strategy, task environment and cultural differences on this relationship. The conceptual model is explored based on a survey of 76

MNC Headquarters as Global Network Orchestrators

DEFF Research Database (Denmark)

Valentino, Alfredo; Nell, Phillip Christopher; Hotho, Jasper J.

2014-01-01

Despite increased interest in headquarters (HQ) and their activities, we still lack a comprehensive understanding of the drivers of HQ relocations and their consequences. We seek to address this gap by examining whether HQ relocations are primarily driven by cost-reduction or value-creation motiv...

Understanding Agency Problems in Headquarters-Subsidiary Relationships in Multinational Corporations

DEFF Research Database (Denmark)

Kostova, Tatiana; Nell, Phillip Christopher; Hoenen, Anne Kristin

2016-01-01

This paper proposes an agency model for headquarters-subsidiary relationships in multinational organizations with headquarters as the principal and the subsidiary as the agent. As a departure from classical agency theory, our model is developed for the unit level of analysis and considers two root...... causes of the agency problem—self-interest and bounded rationality. We argue that in the organizational setting, one cannot assume absolute self-interest and perfect rationality of agents (subsidiaries) but should allow them to vary. We explain subsidiary-level variation through a set of internal...... organizational and external social conditions in which the headquarters-subsidiary agency dyad is embedded. We then discuss several agency scenarios reflecting various levels of self-interest and rationality that lead to different manifestations of the agency problem. The proposed framework can inform more...

Cutting Fat or Removing the Brain: Is the Divisional ADA Battalion Headquarters Necessary?

National Research Council Canada - National Science Library

Sauter, Daniel

1998-01-01

.... This monograph examines whether the divisional ADA battalion headquarters, an intermediate headquarters, is necessary to command and control divisional air defense operations in a Force XXI environment...

Key Management Theories ... and What They Have to Say with Regards to Contemporary Headquarters Structures

DEFF Research Database (Denmark)

Nell, Phillip Christopher

2018-01-01

Multinational and multibusiness headquarters increasingly structure their headquarters in novel ways. They use several locations spread around the world, differentiate different types of headquarters activities in a very fine-grained way, they temporarily relocate top management teams, or relocate...

76 FR 19467 - Weyerhaeuser Company, Corporate Headquarters Including On-Site Leased Workers From Volt Services...

Science.gov (United States)

2011-04-07

... employed on-site at the Federal Way, Washington location of Weyerhaeuser Company, Corporate Headquarters... Company, Corporate Headquarters to be considered leased workers. Based on these findings, the Department... Federal Way, Washington location of Weyerhaeuser Company, Corporate Headquarters. The amended notice...

75 FR 76040 - Weyerhaeuser Company Corporate Headquarters Including On-Site Leased Workers From Volt Services...

Science.gov (United States)

2010-12-07

... Assistance on June 2, 2010, applicable to workers of Weyerhaeuser Company, Corporate Headquarters, including... Weyerhaeuser Company, Corporate Headquarters to be considered leased workers. Based on these findings, the... the Federal Way, Washington location of Weyerhaeuser Company, Corporate Headquarters. The amended...

12 CFR 268.101 - General policy for equal opportunity.

Science.gov (United States)

2010-01-01

... Discrimination in Employment Act (ADEA) (29 U.S.C. 621 et seq.), the Equal Pay Act (29 U.S.C. 206(d)), or the... 12 Banks and Banking 3 2010-01-01 2010-01-01 false General policy for equal opportunity. 268.101... RESERVE SYSTEM RULES REGARDING EQUAL OPPORTUNITY Board Program To Promote Equal Opportunity § 268.101...

49 CFR 268.1 - Definitions.

Science.gov (United States)

2010-10-01

... TRANSPORTATION MAGNETIC LEVITATION TRANSPORTATION TECHNOLOGY DEPLOYMENT PROGRAM Overview § 268.1 Definitions. As used in this part— CMAQ means Congestion Mitigation and Air Quality Improvement Program (23 U.S.C. 149... Stat. 1978). Under that usage any corridor exhibiting Partnership Potential must at least meet the...

When salespeople develop negative headquarters stereotypes: performance effects and managerial remedies

OpenAIRE

Homburg, Christian; Wieseke, Jan; Lukas, Bryan A.; Mikolon, Sven

2011-01-01

This study examines the performance implications that organizations may suffer when their salespeople develop negative stereotypes of their corporate headquarters. How such stereotypes can be remedied through managerial action is also examined. The study draws on matched data from four different sources: sales managers, salespeople, customers, and company reports. Findings indicate that negative headquarters stereotypes among salespeople are associated with poor marketing-related ...

78 FR 52982 - Experian, Experian US Headquarters: Corporate Departments (Finance, HRMD, Contracts, Corporate...

Science.gov (United States)

2013-08-27

...,506R] Experian, Experian US Headquarters: Corporate Departments (Finance, HRMD, Contracts, Corporate... Headquarters: Corporate Departments (finance, HRMD, Contracts, Corporate Marketing, Global Corporate Systems... (finance, HRMD, Contracts, Corporate Marketing, Global Corporate Systems, Legal & Regulatory, Risk...

Communicating Science to Impact Learning? A Phenomenological Inquiry into 4th and 5th Graders' Perceptions of Science Information Sources

Science.gov (United States)

Gelmez Burakgazi, Sevinc; Yildirim, Ali; Weeth Feinstein, Noah

2016-01-01

Rooted in science education and science communication studies, this study examines 4th and 5th grade students' perceptions of science information sources (SIS) and their use in communicating science to students. It combines situated learning theory with uses and gratifications theory in a qualitative phenomenological analysis. Data were gathered…

40 CFR 268.35 - Waste specific prohibitions-petroleum refining wastes.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Waste specific prohibitions-petroleum refining wastes. 268.35 Section 268.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... generator may use knowledge of the waste. If the waste contains constituents in excess of the applicable...

40 CFR 268.36 - Waste specific prohibitions-inorganic chemical wastes

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Waste specific prohibitions-inorganic chemical wastes 268.36 Section 268.36 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... generator may use knowledge of the waste. If the waste contains regulated constituents in excess of the...

Innovative building automation concept for Pumavision Headquarters. Where Pimas are feeling well; Innovatives Gebaeudeautomationskonzept fuer Pumavision Headquarters. Wo Pumas sich wohl fuehlen sollen

Energy Technology Data Exchange (ETDEWEB)

Habermann, Ralf [IPM Gebaeudeleittechnik GmbH, Feucht bei Nuernberg (Germany); Kerz, Thomas [Siemens-Div. Building Technologies Deutschland, Frankfurt am Main (Germany). Business Unit CPS; Vogel, Helmut [Siemens-Div. Building Technologies Deutschland, Muenchen (Germany). Business Unit CPS Region Bayern

2011-03-15

The sport's and lifestyle company PUMA (Herzogenaurach, Federal Republic of Germany) claims the establishment of the first climate neutral corporate headquarter of its industry. Therefore, the electricity for the new 35,000 m{sup 2} large corporate headquarters exclusively results from renewable energy sources. The conversion of this goal is supported by the interdisciplinary building automation system Desigo from Siemens AG (Munich, Federal Republic of Germany). The basic heating and basic cooling of the main building are performed by a concrete core tempering. A part of the heating and cooling is produced by means of two heat pumps.

40 CFR 268.20 - Waste specific prohibitions-Dyes and/or pigments production wastes.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Waste specific prohibitions-Dyes and/or pigments production wastes. 268.20 Section 268.20 Protection of Environment ENVIRONMENTAL... Disposal § 268.20 Waste specific prohibitions—Dyes and/or pigments production wastes. (a) Effective August...

USAFRICOM Headquarters: The Complexity of Moving the Headquarters to the Continent of Africa and its Impact on the Army’s Organizational Design and Operational Approach

Science.gov (United States)

2016-06-10

partners: 1. Somalia–fighting piracy 2. South Africa–diplomatic relations 6 3. Liberia –fighting Ebola /UN mission 4. Nigeria–Boko Haram threat...offices to address issues on the continent.9 Liberia was one of the few countries 18 considered that welcomed the presence of a headquarters in their...only small countries like Liberia welcome a headquarters in Africa, while the larger countries do not welcome the idea. However, there has not been

Proceedings of the 11th World Conference on Mobile and Contextual Learning

OpenAIRE

Specht, Marcus; Sharples, Mike; Multisilta, Jari

2013-01-01

Specht, M., Sharples, M., & Multisilta, J. (Eds.) (2012). Proceedings of the 11th World Conference on Mobile and Contextual Learning (mLearn 2012). October, 16-18, 2012, Helsinki, Finland. Published by CEUR Workshop Proceedings, 2012, Vol. 995. Retrieved from http://ceur-ws.org/Vol-955/

An analysis of headquarters location in the Canadian oil and gas sector

International Nuclear Information System (INIS)

Hirsch, K.T.

1993-04-01

Headquarters location theory identifies several factors which are expected to influence the location of corporate head offices. Some of these factors directly affect the costs of operation and the basic profitability of the company, such as the cost of office space, tax levels, availability of qualified labour, cost of labour, proximity to corporate activities, and agglomeration with other services and companies. Headquarters location theory is applied to Canada's energy sector. During the previous 27 years, concentration of energy company headquarters has shifted from Toronto to Calgary. A regression model tests the extent to which those factors identified in the literature appear to be statistically significant for the headquarters relocation experience in Canada's energy sector. The results of the tests suggest that certain factors do appear to significantly influence relocation decisions. These factors are agglomeration with other oil and gas companies, and relative proximity to oil and gas operations (which unexpectedly displayed a negative coefficient). The agglomeration factor was by far the most significant. 44 refs., 3 figs., 2 tabs

The Influence of Transverse CSR Structure on Headquarters/Subsidiary Integration

Directory of Open Access Journals (Sweden)

Luciano Barin Cruz

2010-07-01

Full Text Available Some studies have already highlighted the effects of the introduction of Corporate Social Responsibility [CSR] projects into Multinational Corporations’ [MNC] strategies. However, little attention has been paid to the influence of transverse CSR structure on headquarters/subsidiary integration. In this article, we begin with the following question: What is the influence of the introduction of a centralized/decentralized structure on conducting a CSR strategy in a MNC? Our main objective is to identify conditions through which the structure of the CSR department influences the CSR strategy of the MNC. We define transverse CSR structure as: (1 the existence of a CSR directory at the headquarters level and a CSR representative at the subsidiary level, and (2 the existence of representatives from different areas who participate in meetings or committees to make decisions about CSR strategy. We argue that a transverse CSR structure favors consideration of global and local CSR demands by headquarters and subsidiaries. This process takes place through the mediation of three main elements: information exchange, awareness activities and definition of objectives.

The Regional Special Operations Headquarters: Franchising the NATO Model as a Hedge in Lean Times

Science.gov (United States)

2012-04-01

1 AIR FORCE FELLOWS AIR UNIVERSITY THE REGIONAL SPECIAL OPERATIONS HEADQUARTERS: FRANCHISING THE NATO MODEL AS A HEDGE IN LEAN...Headquarters: Franchising The NATO Model As A Hedge In Lean Times 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...it is not copyrighted, but is the property of the United States government. 3 The Regional Special Operations Headquarters: Franchising the

Physical fitness and health education program at NASA Headquarters

Science.gov (United States)

Angotti, Cathy

1993-01-01

The topics discussed include the following: policy procedures to enter the NASA Headquarters Physical Fitness and Health Program; eligibility; TDY eligibility; health promotions offered; and general facility management.

The use of mobile learning by 6th-year medical students in a minimally-supported environment

OpenAIRE

Ken Masters; Zahra Al-Rawahi

2012-01-01

Objectives: The study aims to identify the impact of minimal support on medical students' mobile learning activities. Methods: The study was performed at the Sultan Qaboos University, Oman, on 129 medical students in their 7th year. The study consisted of a quantitative survey of the students, focussing on their mobile learning activities during their 6th year, while using their own mobile devices (such as smart phones) for mobile learning activities. In addition, their perceptions of barrier...

Corporate headquarters as physical embodiments of organisational change

NARCIS (Netherlands)

van Marrewijk, A.H.

2009-01-01

Purpose: The purpose of this paper is to explore the interdependency of corporate architecture and organisation cultural change. Corporate headquarters have become symbols of corporate change ambitions to endure cultural value sets. The paper seeks to contribute to the growing interest in the

When Do Distance Effects Become Empirically Observable? An Investigation in the Context of Headquarters Value Creation for Subsidiaries

OpenAIRE

Beugelsdijk, Sjoerd; Nell, Phillip C.; Ambos, Björn

2017-01-01

Integrating distance research with the behavioral strategy literature on MNC headquarters-subsidiary relations, this paper explores how the distance between headquarters and subsidiaries relates to value added by the headquarters. We show for 124 manufacturing subsidiaries in Europe that, on average, distance is unrelated to value added by headquarters but that this effect is contingent upon the extent to which the subsidiary is locally embedded. Only after a certain threshold level of subsid...

19th International Conference on Interactive Collaborative Learning

CERN Document Server

Guralnick, David; Uhomoibhi, James

2017-01-01

This book presents the proceedings of the 19th International Conference on Interactive Collaborative Learning, held 21-23 September 2016 at Clayton Hotel in Belfast, UK. We are currently witnessing a significant transformation in the development of education. The impact of globalisation on all areas of human life, the exponential acceleration of developments in both technology and the global markets, and the growing need for flexibility and agility are essential and challenging elements of this process that have to be addressed in general, but especially in the context of engineering education. To face these topical and very real challenges, higher education is called upon to find innovative responses. Since being founded in 1998, this conference has consistently been devoted to finding new approaches to learning, with a focus on collaborative learning. Today the ICL conferences have established themselves as a vital forum for the exchange of information on key trends and findings, and of practical lessons le...

When Do Distance Effects Become Empirically Observable? An Investigation in the Context of Headquarters Value Creation for Subsidiaries

NARCIS (Netherlands)

Beugelsdijk, Sjoerd; Nell, Phillip C.; Ambosd, Bjoern

Integrating distance research with the behavioral strategy literature on MNC headquarters-subsidiary relations, this paper explores how the distance between headquarters and subsidiaries relates to value added by the headquarters. We show for 124 manufacturing subsidiaries in Europe that, on

local government headquarters and spatial interaction within rivers

African Journals Online (AJOL)

user

headquarters and rural hinterland settlements in Rivers South East ... of Rivers State is responsible for over seventy percent (70%) of the total employment in the ... even proportion and balanced development for all could not completely ... Rivers West ... agricultural under development, unemployment, poor quality of life due.

6th International Conference in Methodologies and intelligent Systems for Technology Enhanced Learning

CERN Document Server

Prieta, Fernando; Mascio, Tania; Gennari, Rosella; Rodríguez, Javier; Vittorini, Pierpaolo

2016-01-01

The 6th International Conference in Methodologies and intelligent Systems for Technology Enhanced Learning held in Seville (Spain) is host by the University of Seville from 1st to 3rd June, 2016. The 6th edition of this conference expands the topics of the evidence-based TEL workshops series in order to provide an open forum for discussing intelligent systems for TEL, their roots in novel learning theories, empirical methodologies for their design or evaluation, stand-alone solutions or web-based ones. It intends to bring together researchers and developers from industry, the education field and the academic world to report on the latest scientific research, technical advances and methodologies.

43 CFR 30.268 - May I demand a hearing regarding the tribal purchase option decision?

Science.gov (United States)

2010-10-01

... tribal purchase option decision? 30.268 Section 30.268 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE HEARINGS PROCEDURES Tribal Purchase of Interests Under Special Statutes § 30.268 May I demand a hearing regarding the tribal purchase option decision? Yes. You may file with...

STUDY OF GEOGRAPHY TEXTBOOKS FOR 9th, 10th, 11th AND 12th GRADES. CASE STUDY: MAHARASHTRA STATE, INDIA

Directory of Open Access Journals (Sweden)

MARIANA-DOINA CÎINEANU

2017-02-01

Full Text Available The introduction conveys some data on learning in India and on designing Geography textbooks in this country. The present paper is reliant on four Geography textbooks, ranging from the 9th to the 12th grade. As regards each textbook, the study considers their learning units, then analyses their structure, the unitary way of designing them, the components of the panels of authors, the texts, illustrative materials, drills, learning activities, language, the wealth of Geography lexis, and the glossary.

Managing Market Segmentatıon for Dıfferent Brands of the same Headquarter

Directory of Open Access Journals (Sweden)

Ahmet Hakan Özkan

2016-10-01

Full Text Available Brand management is inevitable for sustainable marketing. Civil aviation companies focus on sustainable marketing, because of their long-term investments. Customer loyalty is one of the most improtant factors of sustainable marketing. It is known that, if there is no certain limit or border, segmentation damages the reputation of the brands and it is one of the most important threats of sustainable marketing. Segmentation can be done by using new brands, but this process has its own constraints. Such constraints are related with the reputability of the company. To evaluate the impact of a new brand on reputability, service quality is taken as a metric and SERVQUAL is used. The customers of two civil aviation companies participated the study. These two aviation companies have the same headquarter, but they have different brand management strategies. One of them is globally reputable and it is the headquarter company. 166 questionnaires of the 83 participants are evaluated. It is seen that the service quality perception on the brand of the headquarter company did not change and the new brand did not effect its reputability. New brand created its own market or took a share from the other civil aviation companies which attract the customers of the headquarter company with their lower prices.

Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory.

Science.gov (United States)

Penke, Zsuzsa; Morice, Elise; Veyrac, Alexandra; Gros, Alexandra; Chagneau, Carine; LeBlanc, Pascale; Samson, Nathalie; Baumgärtel, Karsten; Mansuy, Isabelle M; Davis, Sabrina; Laroche, Serge

2014-01-05

It is well established that Zif268/Egr1, a member of the Egr family of transcription factors, is critical for the consolidation of several forms of memory; however, it is as yet uncertain whether increasing expression of Zif268 in neurons can facilitate memory formation. Here, we used an inducible transgenic mouse model to specifically induce Zif268 overexpression in forebrain neurons and examined the effect on recognition memory and hippocampal synaptic transmission and plasticity. We found that Zif268 overexpression during the establishment of memory for objects did not change the ability to form a long-term memory of objects, but enhanced the capacity to form a long-term memory of the spatial location of objects. This enhancement was paralleled by increased long-term potentiation in the dentate gyrus of the hippocampus and by increased activity-dependent expression of Zif268 and selected Zif268 target genes. These results provide novel evidence that transcriptional mechanisms engaging Zif268 contribute to determining the strength of newly encoded memories.

The Development of Learning Model Based on Problem Solving to Construct High-Order Thinking Skill on the Learning Mathematics of 11th Grade in SMA/MA

Science.gov (United States)

Syahputra, Edi; Surya, Edy

2017-01-01

This paper is a summary study of team Postgraduate on 11th grade. The objective of this study is to develop a learning model based on problem solving which can construct high-order thinking on the learning mathematics in SMA/MA. The subject of dissemination consists of Students of 11th grade in SMA/MA in 3 kabupaten/kota in North Sumatera, namely:…

There's No Place Like Home: The Profitability Gap between Headquarters and their Foreign Subsidiaries

OpenAIRE

Dischinger, Matthias; Riedel, Nadine

2009-01-01

Using a large panel data set for European firms, this paper provides evidence that operations at multinational headquarters are significantly more profitable than perations at their foreign subsidiaries. The effect turns out to be robust and quantitatively large. Our findings suggest that the profitability gap is partly driven by agency costs which arise if value-driving functions are managed by a subsidiary that is geographically separated from the headquarters management. In line with falli...

New management structure at headquarters

Science.gov (United States)

On July 1, 1987, AGU Executive Director Fred Spilhaus informed the AGU staff that Judy C. Holoviak has been promoted to the position of Group Director. This is a new management position with responsibility for more than one division. Both the Publications Division and the newly formed Public Information and Marketing Division will report to Holoviak, as will the new Special Assistant for Nonprint Publications.Spilhaus explained that this new position will permit the headquarters management staff to be responsive to the current AGU growth. A stronger management structure is needed to take advantage of the many opportunities facing the Union. In pointing to the initiatives identified by the Planning Committee, he stated that continued growth is the only likely course for AGU.

Attention in words, not in deeds : Effects of attention dissonance on headquarters-subsidiary communication in multinational corporations

NARCIS (Netherlands)

ul Haq, Hammad; Drogendijk, Rian; Blankenburg Holm, Desiree

2017-01-01

We introduce the notion of attention dissonance, where the subsidiary within a headquarter-subsidiary relationship feels that headquarters’ attention at the cognitive level, reflected in its strategic intentions (attention perspective), is not aligned with the routine actions the headquarters

A confrontation with reality - Proceedings of the 19th Association for Learning Technology Conference

NARCIS (Netherlands)

Hawkridge, David; Verjans, Steven; Wilson, Gail

2012-01-01

Hawkridge, D., Verjans, S., & Wilson, G. (Eds.) (2012). A confrontation with reality - Proceedings of the 19th Association for Learning Technology Conference (ALT-C 2012). September, 11-14, 2012, Manchester, UK.

The Texts of The Agency's Agreements with the Republic of Austria. I. Headquarters Agreement. Amendments

Energy Technology Data Exchange (ETDEWEB)

NONE

1970-09-04

The text of the Agreement between the International Atomic Energy Agency and the Republic of Austria Amending the Agreement of 11 December 1957 Regarding the Headquarters of the International Atomic Energy Agency, which was signed on 4 June 1970, is reproduced in this document for the information of all Members. Members will be informed of the entry into force of the Amendments to the Headquarters Agreement.

The Texts of The Agency's Agreements with the Republic of Austria. I. Headquarters Agreement. Amendments

International Nuclear Information System (INIS)

1970-01-01

The text of the Agreement between the International Atomic Energy Agency and the Republic of Austria Amending the Agreement of 11 December 1957 Regarding the Headquarters of the International Atomic Energy Agency, which was signed on 4 June 1970, is reproduced in this document for the information of all Members. Members will be informed of the entry into force of the Amendments to the Headquarters Agreement

THE ENVIRONMENTAL STRATEGY OF MULTINATIONAL ENTERPRISE - MANAGING THE RELATIONSHIP BETWEEN THE HEADQUARTER AND SUBSIDIARIES

Directory of Open Access Journals (Sweden)

Roselei Haag

2017-04-01

Full Text Available This paper presents a literature review that searches to understand how the environmental strategy must be diffused throughout the structure of the multinational enterprise (MNE, within the scope of the studies on enterprises’ internationalization. Literature has contributed to the understanding of the relationships between headquarters and subsidiaries of MNEs, identifying contingencies where the headquarters should grant greater autonomy to certain subsidiaries. After analyzing the literature, we propose a research agenda seeking to expand the field of knowledge on the adoption of sustainability strategies in subsidiaries.

Relationship between Motivation for Learning EFL and Intrinsic Motivation for Learning in General among Japanese Elementary School Students

Science.gov (United States)

Carreira, Junko Matsuzaki

2011-01-01

This study investigated children's motivation for learning English as a foreign language (EFL) and intrinsic motivation for learning in general. The participants were 268 third-sixth graders in a public school in Japan. Data were collected using two questionnaires, one measuring motivation for learning EFL and the other investigating intrinsic…

40 CFR Appendix Viii to Part 268 - LDR Effective Dates of Injected Prohibited Hazardous Wastes

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false LDR Effective Dates of Injected Prohibited Hazardous Wastes VIII Appendix VIII to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION... to Part 268—LDR Effective Dates of Injected Prohibited Hazardous Wastes National Capacity LDR...

The Effect of Headquarter Integration Mechanisms on Subsidiaries’ New Product Success: From Control to Coordination Mechanism

Directory of Open Access Journals (Sweden)

Firmanzah

2007-10-01

Full Text Available New product launching (NPL to the local market by subsidiary managers is a strategic activity, which requires organizational supports from MNC global network. The NPL activity is marked by high level of uncertainty, risk, and market failure. Thus, a headquarter needs to integrate the subsidiary NPL into global strategy. There are two mechanisms to integrate subsidiaries’ activities during NPL process; coordination and control process. By testing the effect of each mechanism on role clarity and functional conflict, I found that coordination mechanism increase role clarity between headquarter and subsidiaries’ managers. In contrast, exercising control mechanism reduces role clarity and functional conflict between headquarter and subsidiaries’ managers during NPL. This research shows that both role clarity and functional conflict increase new product commercial performance introduced by subsidiary in the local market.

Evaluation of screening for oral cancer and precancer in a company headquarters.

Science.gov (United States)

Downer, M C; Evans, A W; Hughes Hallet, C M; Jullien, J A; Speight, P M; Zakrzewska, J M

1995-04-01

Oral cancer and precancer appear to fulfil many of the criteria for a disease suitable for mass screening. Several commercial organisations in the UK have introduced screening for their employees. One program has been formally evaluated over the course of 1 yr. Of 553 company headquarters staff aged > or = 40 yr, 292 (53%) responded to the well-publicised screening invitation and received a simple clinical examination of the oral mucosa from one of two company dentists. In addition, 17 staff were screened from a separate company work-site. After screening, subjects were examined independently by an oral medicine specialist with access to the relevant diagnostic aids. The dentists' screening decisions were validated against the specialist's definitive diagnoses (the 'gold standard'). The true prevalence of subjects with lesions diagnosed as positive (white patch, red patch or ulcer of greater than 2 weeks' duration) was 17 (5.5%). Overall, sensitivity was 0.71 and specificity, 0.99. The compliance rate to screening among headquarters subjects in seven occupational categories did not differ significantly from the occupational profile for all headquarters personnel. Estimates of relative risk of a positive diagnosis were calculated by logistic regression for five independent variables; gender, age, moderate smoking, heavy smoking, and smoking combined with greater than low risk alcohol consumption. Only heavy smoking (> or = 20 cigarettes per day) produced a significant odds ratio (3.43, P < 0.05).

The role of location in headquarters-subsidiaries relationships: An analysis of French multinationals in emerging markets

OpenAIRE

Hanane Beddi; Ulrike Mayrhofer

2010-01-01

International audience; This paper examines the role of location in the relationships established between headquarters and foreign subsidiaries. The analysis focuses on new challenges faced by MNEs from mature economies, considering the growing importance of subsidiaries located in emerging countries. The empirical study is based on three in-depth case-studies of French multinationals. The authors conducted 31 interviews with managers from both the headquarters and foreign subsidiaries. The f...

The Effects of Using Diorama on 7th Grade Students' Academic Achievement and Science Learning Skills

Science.gov (United States)

Aslan Efe, Hulya

2017-01-01

This study aims to investigate the effects of using diorama on 7th grade students' academic achievement and science learning skills in "human being and environment relation" unit. The participants were 49 (E:25, C:24) 7th grade students studying during 2015-16 academic year in Diyarbakir, Turkey. An achievement test and "science…

Problem-Based Learning Method: Secondary Education 10th Grade Chemistry Course Mixtures Topic

Science.gov (United States)

Üce, Musa; Ates, Ismail

2016-01-01

In this research; aim was determining student achievement by comparing problem-based learning method with teacher-centered traditional method of teaching 10th grade chemistry lesson mixtures topic. Pretest-posttest control group research design is implemented. Research sample includes; two classes of (total of 48 students) an Anatolian High School…

7th International Conference in Methodologies and Intelligent Systems for Technology Enhanced Learning

CERN Document Server

Gennari, Rosella; Mascio, Tania; Rodríguez, Sara; Prieta, Fernando; Ramos, Carlos; Silveira, Ricardo

2017-01-01

This book presents the outcomes of the 7th International Conference in Methodologies and Intelligent Systems for Technology Enhanced Learning (MIS4TEL'17), hosted by the Polytechnic of Porto, Portugal from 21 to 23 June 2017. Expanding on the topics of the previous conferences, it provided an open forum for discussing intelligent systems for technology enhanced learning (TEL) and their roots in novel learning theories, empirical methodologies for their design or evaluation, stand-alone and web-based solutions, and makerspaces. It also fostered entrepreneurship and business startup ideas, bringing together researchers and developers from industry, education and the academic world to report on the latest scientific research, technical advances and methodologies.

The Effect of Jigsaw Technique on 6th Graders' Learning of Force and Motion Unit and Their Science Attitudes and Motivation

Science.gov (United States)

Ural, Evrim; Ercan, Orhan; Gençoglan, Durdu Mehmet

2017-01-01

The study aims to investigate the effects of jigsaw technique on 6th graders' learning of "Force and Motion" unit, their science learning motivation and their attitudes towards science classes. The sample of the study consisted of 49 6th grade students from two different classes taking the Science and Technology course at a government…

Lower expression of glutamic acid decarboxylase 67 in the prefrontal cortex in schizophrenia: contribution of altered regulation by Zif268.

Science.gov (United States)

Kimoto, Sohei; Bazmi, H Holly; Lewis, David A

2014-09-01

Cognitive deficits of schizophrenia may be due at least in part to lower expression of the 67-kDa isoform of glutamic acid decarboxylase (GAD67), a key enzyme for GABA synthesis, in the dorsolateral prefrontal cortex of individuals with schizophrenia. However, little is known about the molecular regulation of lower cortical GAD67 levels in schizophrenia. The GAD67 promoter region contains a conserved Zif268 binding site, and Zif268 activation is accompanied by increased GAD67 expression. Thus, altered expression of the immediate early gene Zif268 may contribute to lower levels of GAD67 mRNA in the dorsolateral prefrontal cortex in schizophrenia. The authors used polymerase chain reaction to quantify GAD67 and Zif268 mRNA levels in dorsolateral prefrontal cortex area 9 from 62 matched pairs of schizophrenia and healthy comparison subjects, and in situ hybridization to assess Zif268 expression at laminar and cellular levels of resolution. The effects of potentially confounding variables were assessed in human subjects, and the effects of antipsychotic treatments were tested in antipsychotic-exposed monkeys. The specificity of the Zif268 findings was assessed by quantifying mRNA levels for other immediate early genes. GAD67 and Zif268 mRNA levels were significantly lower and were positively correlated in the schizophrenia subjects. Both Zif268 mRNA-positive neuron density and Zif268 mRNA levels per neuron were significantly lower in the schizophrenia subjects. These findings were robust to the effects of the confounding variables examined and differed from other immediate early genes. Deficient Zif268 mRNA expression may contribute to lower cortical GAD67 levels in schizophrenia, suggesting a potential mechanistic basis for altered cortical GABA synthesis and impaired cognition in schizophrenia.

The Effect of Headquarter Integration Mechanisms on Subsidiaries’ New Product Success: From Control to Coordination Mechanism

Directory of Open Access Journals (Sweden)

Firmanzah Firmanzah

2013-07-01

Full Text Available New product launching (NPL to the local market by subsidiary managers is a strategic activity, which requires organizational supports from MNC global network. The NPL activity is marked by high level of uncertainty, risk, and market failure. Thus, a headquarter needs to integrate the subsidiary NPL into global strategy. There are two mechanisms to integrate subsidiaries’ activities during NPL process; coordination and control process. By testing the effect of each mechanism on role clarity and functional conflict, I found that coordination mechanism increase role clarity between headquarter and subsidiaries’ managers. In contrast, exercising control mechanism reduces role clarity and functional conflict between headquarter and subsidiaries’ managers during NPL. This research shows that both role clarity and functional conflict increase new product commercial performance introduced by subsidiary in the local market. Keywords: new product launching (NPL, coordination mechanism, control mechanism, and new product performance

32 CFR 1605.8 - Staff of Region Headquarters for Selective Service.

Science.gov (United States)

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Staff of Region Headquarters for Selective... SERVICE SYSTEM SELECTIVE SERVICE SYSTEM ORGANIZATION Region Administration § 1605.8 Staff of Region..., the staff of each region for Selective Service shall consist of as many officers, either military or...

40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes VII Appendix VII to Part 268 Protection of Environment ENVIRONMENTAL... VII to Part 268—LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes Table 1—Effective...

Heart House: Where Doctors Learn

Science.gov (United States)

American School and University, 1978

1978-01-01

The new learning center and administrative headquarters of the American College of Cardiology in Bethesda, Maryland, contain a unique classroom equipped with the highly sophisticated audiovisual aids developed to teach the latest techniques in the diagnosis and treatment of heart disease. (Author/MLF)

Imam Sahib Border Police Company Headquarters in Kunduz Province: $7.3 Million Facility Sits Largely Unused

Science.gov (United States)

2013-01-01

Afghanistan Border Police Battalion (BN) Headquarters (HQ) to replace an existing sub-standard fac ility. The standard ABP BN HQ manning documents call for...current manning of the site revealed that an ABP BN HQ unit is now utilizing this as a headquarters. An ABP BN HQ has a tashkil manning of 59 personnel...The facility was built for 175 personnel. The difference in designs between an ABP battalion and a company is the amount of barrack space. The build

49 CFR 268.7 - Federal/State share and restrictions on the uses of Federal Maglev Funds.

Science.gov (United States)

2010-10-01

... of Federal Maglev Funds. 268.7 Section 268.7 Transportation Other Regulations Relating to... Federal Maglev Funds. (a) Federal share. The Federal share of Full Projects Costs shall be not more than 2...) Restrictions on the uses of Federal Maglev Funds. (1) Federal Maglev Funds may be applied only to Eligible...

Technical and Clinical Outcomes Following Colonic Stenting: A Seven-Year Analysis of 268 Procedures

Energy Technology Data Exchange (ETDEWEB)

Little, M. W.; Oakley, T.; Briggs, J. H.; Sutcliffe, J. A.; Allouni, A. K.; Makris, G.; Bratby, M. J.; Tapping, C. R.; Patel, R.; Wigham, A.; Anthony, S.; Phillips-Hughes, J.; Uberoi, R., E-mail: Raman.uberoi@ouh.nhs.uk [Oxford University Hospitals NHS Foundation Trust, Department of Interventional Radiology, John Radcliffe Hospital (United Kingdom)

2016-10-15

AimsTo assess the factors contributing to the technical and clinical success of colorectal stenting for large bowel obstruction.Methodology268 cases of colonic stenting for large bowel obstruction were performed in 249 patients of mean age of 72 years (28–98) between 2006 and 2013. The majority of strictures were due to malignant disease, 244/268 (91 %). Diverticular strictures accounted for 24/268 (9 %).ResultsOverall technical success rate was 81 % (217/268), with a clinical success rate of 65 % (174/268). Duration of symptoms ranged from 0 to 180 days (mean 8 days). Technical success rate was seen to decrease with increasing symptom duration. For symptom duration of less than 1 week, technical success was 85.4 % (181/212) versus 69.6 % (39/56) for those with symptoms of greater than a week (p < 0.05). Clinical success rates fell from 71.3 % (107/150) to 59.3 % (70/118) (p < 0.05) when attempting to stent lesions of greater than 5 cm. There was also a significant reduction in clinical success when stenting lesions on a bend rather than a straight segment of colon 75.7 % (109/144) versus 59.7 % (74/124) (p < 0.05). A total of 20 (7.46 %) perforations were identified during the study. Stent migration occurred in 6.6 % of cases. In-stent stenosis occurred in 3.3 %. The overall 30-day all cause mortality rate was 9 %.ConclusionLesion size, location and duration of obstructive symptoms are statistically significant determinants of patient outcome. These factors could be used to advise patient selection for colonic stenting or direct progression to surgical intervention.

Technical and Clinical Outcomes Following Colonic Stenting: A Seven-Year Analysis of 268 Procedures

International Nuclear Information System (INIS)

Little, M. W.; Oakley, T.; Briggs, J. H.; Sutcliffe, J. A.; Allouni, A. K.; Makris, G.; Bratby, M. J.; Tapping, C. R.; Patel, R.; Wigham, A.; Anthony, S.; Phillips-Hughes, J.; Uberoi, R.

2016-01-01

AimsTo assess the factors contributing to the technical and clinical success of colorectal stenting for large bowel obstruction.Methodology268 cases of colonic stenting for large bowel obstruction were performed in 249 patients of mean age of 72 years (28–98) between 2006 and 2013. The majority of strictures were due to malignant disease, 244/268 (91 %). Diverticular strictures accounted for 24/268 (9 %).ResultsOverall technical success rate was 81 % (217/268), with a clinical success rate of 65 % (174/268). Duration of symptoms ranged from 0 to 180 days (mean 8 days). Technical success rate was seen to decrease with increasing symptom duration. For symptom duration of less than 1 week, technical success was 85.4 % (181/212) versus 69.6 % (39/56) for those with symptoms of greater than a week (p < 0.05). Clinical success rates fell from 71.3 % (107/150) to 59.3 % (70/118) (p < 0.05) when attempting to stent lesions of greater than 5 cm. There was also a significant reduction in clinical success when stenting lesions on a bend rather than a straight segment of colon 75.7 % (109/144) versus 59.7 % (74/124) (p < 0.05). A total of 20 (7.46 %) perforations were identified during the study. Stent migration occurred in 6.6 % of cases. In-stent stenosis occurred in 3.3 %. The overall 30-day all cause mortality rate was 9 %.ConclusionLesion size, location and duration of obstructive symptoms are statistically significant determinants of patient outcome. These factors could be used to advise patient selection for colonic stenting or direct progression to surgical intervention.

Technical and Clinical Outcomes Following Colonic Stenting: A Seven-Year Analysis of 268 Procedures.

Science.gov (United States)

Little, M W; Oakley, T; Briggs, J H; Sutcliffe, J A; Allouni, A K; Makris, G; Bratby, M J; Tapping, C R; Patel, R; Wigham, A; Anthony, S; Phillips-Hughes, J; Uberoi, R

2016-10-01

To assess the factors contributing to the technical and clinical success of colorectal stenting for large bowel obstruction. 268 cases of colonic stenting for large bowel obstruction were performed in 249 patients of mean age of 72 years (28-98) between 2006 and 2013. The majority of strictures were due to malignant disease, 244/268 (91 %). Diverticular strictures accounted for 24/268 (9 %). Overall technical success rate was 81 % (217/268), with a clinical success rate of 65 % (174/268). Duration of symptoms ranged from 0 to 180 days (mean 8 days). Technical success rate was seen to decrease with increasing symptom duration. For symptom duration of less than 1 week, technical success was 85.4 % (181/212) versus 69.6 % (39/56) for those with symptoms of greater than a week (p < 0.05). Clinical success rates fell from 71.3 % (107/150) to 59.3 % (70/118) (p < 0.05) when attempting to stent lesions of greater than 5 cm. There was also a significant reduction in clinical success when stenting lesions on a bend rather than a straight segment of colon 75.7 % (109/144) versus 59.7 % (74/124) (p < 0.05). A total of 20 (7.46 %) perforations were identified during the study. Stent migration occurred in 6.6 % of cases. In-stent stenosis occurred in 3.3 %. The overall 30-day all cause mortality rate was 9 %. Lesion size, location and duration of obstructive symptoms are statistically significant determinants of patient outcome. These factors could be used to advise patient selection for colonic stenting or direct progression to surgical intervention.

24 CFR 203.268 - Pro rata payment of periodic MIP.

Science.gov (United States)

2010-04-01

... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-Periodic Payment § 203.268 Pro rata payment of periodic MIP. (a) If the insurance contract is terminated...

12 CFR 268.503 - Enforcement of final EEOC decisions.

Science.gov (United States)

2010-01-01

... the decision pursuant to title VII, the ADEA, the Equal Pay Act or the Rehabilitation Act and to seek... RESERVE SYSTEM RULES REGARDING EQUAL OPPORTUNITY Remedies and Enforcement § 268.503 Enforcement of final... Procedures Act, 5 U.S.C. 701 et seq., and the mandamus statute, 28 U.S.C. 1361, or to commence de novo...

12 CFR 268.407 - Civil action: Equal Pay Act.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Civil action: Equal Pay Act. 268.407 Section... Civil action: Equal Pay Act. A complainant is authorized under section 16(b) of the Fair Labor Standards..., if the violation is willful, three years of the date of the alleged violation of the Equal Pay Act...

An evaluation of solar energy for heating a highway maintenance headquarters building.

Science.gov (United States)

1985-01-01

A highway maintenance area headquarters building having overall dimensions of 64 ft - 8 in by 42 ft - 0 in was equipped with an active solar heating system to assist in heating space and domestic hot water. The solar system was instrumented and its o...

The Texts of the Agency's Headquarters Agreement with Austria and Related Agreements

International Nuclear Information System (INIS)

1975-01-01

The texts of six agreements concluded between the Agency and the Republic of Austria as a result of the location of the Agency's headquarters in Austria, which were in force on 31 October 1975, are reproduced in this document for the information of all Members

Directory - Social Media - The National Guard

Science.gov (United States)

Brigade 1st Battalion, 145th Armored Regiment Headquarters and Headquarters Company, 1st Battalion, 145th Florida Air National Guard Florida Guard History Camp Blanding Joint Training Center Wolfpack Company, 1st Force Georgia National Guard Joint Force Headquarters 116th Air Control Wing Flickr Georgia National

IAEA technical meeting: 13th meeting of the IFRC Subcommittee on Atomic and Molecular Data for Fusion. Summary report

International Nuclear Information System (INIS)

Clark, R.E.H.; Peacock, N.J.

2002-11-01

This report briefly describes the proceedings, conclusions and recommendations of the 13th Meeting of the Subcommittee on Atomic and Molecular Data for Fusion of the International Fusion Research Council held on 24-25 June, 2002 at the IAEA Headquarters in Vienna Austria. The report includes an Executive Summary of the Subcommittee from this Meeting. (author)

Chronic stress enhanced fear memories are associated with increased amygdala zif268 mRNA expression and are resistant to reconsolidation.

Science.gov (United States)

Hoffman, Ann N; Parga, Alejandro; Paode, Pooja R; Watterson, Lucas R; Nikulina, Ella M; Hammer, Ronald P; Conrad, Cheryl D

2015-04-01

The chronically stressed brain may present a vulnerability to develop maladaptive fear-related behaviors in response to a traumatic event. In rodents, chronic stress leads to amygdala hyperresponsivity and dendritic hypertrophy and produces a post traumatic stress disorder (PTSD)-like phenotype that includes exaggerated fear learning following Pavlovian fear conditioning and resistance to extinction. It is unknown whether chronic stress-induced enhanced fear memories are vulnerable to disruption via reconsolidation blockade, as a novel therapeutic approach for attenuating exaggerated fear memories. We used a chronic stress procedure in a rat model (wire mesh restraint for 6h/d/21d) to create a vulnerable brain that leads to a PTSD-like phenotype. We then examined freezing behavior during acquisition, reactivation and after post-reactivation rapamycin administration (i.p., 40mg/kg) in a Pavlovian fear conditioning paradigm to determine its effects on reconsolidation as well as the subsequent functional activation of limbic structures using zif268 mRNA. Chronic stress increased amygdala zif268 mRNA during fear memory retrieval at reactivation. Moreover, these enhanced fear memories were unaffected by post reactivation rapamycin to disrupt long-term fear memory. Also, post-reactivation long term memory processing was also associated with increased amygdala (LA and BA), and decreased hippocampal CA1 zif268 mRNA expression. These results suggest potential challenges for reconsolidation blockade as an effective approach in treating exaggerated fear memories, as in PTSD. Our findings also support chronic stress manipulations combined with fear conditioning as a useful preclinical approach to study a PTSD-like phenotype. Copyright © 2015 Elsevier Inc. All rights reserved.

Association of Grade Configuration with School Climate for 7th and 8th Grade Students

Science.gov (United States)

Malone, Marisa; Cornell, Dewey; Shukla, Kathan

2017-01-01

Educational authorities have questioned whether middle schools provide the best school climate for 7th and 8th grade students, and proposed that other grade configurations such as K-8th grade schools may provide a better learning environment. The purpose of this study was to compare 7th and 8th grade students' perceptions of 4 key features of…

A Study of Learning Achievement and Learning Behavior in Biology on “Genes and Chromosomes” Using Storyline Teaching for 12th Grade Students

OpenAIRE

Ubonwan Leawudomchai; Kittima Panprueksa; Somsiri Singlop; Thanawuth Latwong

2016-01-01

The objectives of this research were to study learning achievement and learning behavior in Biology on “genes and chromosomes” using storyline teaching for 12th grade students. The sample for this research consisted of 36 twelfth grade students from Piboonbumpen Demonstration School in the first semester of 2014. The sample was randomly selected for the experimental group using cluster random sampling. The research instruments were the lesson plans using storyline teaching on g...

International Human Resources Management of Japanese, American, and European Firms in Asia : The Roles of Headquarters and Subsidiaries

OpenAIRE

Hiromichi Shibata; Andrew Doyle

2006-01-01

The main role of the headquarters international human resources departments/business units of seven Japanese firms we researched is to manage the Japanese expatriates at their subsidiaries in Asia; they have little involvement with the management of local employees. The headquarters international human resources departments/business units at five researched American firms tend to maintain strong company value/mission that drives use of their performance appraisal/promotion systems for employe...

Communicating Science to Impact Learning? A Phenomenological Inquiry into 4th and 5th Graders' Perceptions of Science Information Sources

Science.gov (United States)

Gelmez Burakgazi, Sevinc; Yildirim, Ali; Weeth Feinstein, Noah

2016-04-01

Rooted in science education and science communication studies, this study examines 4th and 5th grade students' perceptions of science information sources (SIS) and their use in communicating science to students. It combines situated learning theory with uses and gratifications theory in a qualitative phenomenological analysis. Data were gathered through classroom observations and interviews in four Turkish elementary schools. Focus group interviews with 47 students and individual interviews with 17 teachers and 10 parents were conducted. Participants identified a wide range of SIS, including TV, magazines, newspapers, internet, peers, teachers, families, science centers/museums, science exhibitions, textbooks, science books, and science camps. Students reported using various SIS in school-based and non-school contexts to satisfy their cognitive, affective, personal, and social integrative needs. SIS were used for science courses, homework/project assignments, examination/test preparations, and individual science-related research. Students assessed SIS in terms of the perceived accessibility of the sources, the quality of the content, and the content presentation. In particular, some sources such as teachers, families, TV, science magazines, textbooks, and science centers/museums ("directive sources") predictably led students to other sources such as teachers, families, internet, and science books ("directed sources"). A small number of sources crossed context boundaries, being useful in both school and out. Results shed light on the connection between science education and science communication in terms of promoting science learning.

A Holistic Approach to Knowledge Management and Social Learning: lessons learnt from military headquarters

Directory of Open Access Journals (Sweden)

Leoni Warne

2001-11-01

Full Text Available This paper reports on research conducted by the Enterprise Social Learning Architecture (ESLA team of the Defence Science and Technology Organisation. The ESLA team is investigating collaborative social learning within the Australian Defence Organisation (ADO. Social learning is tightly coupled to knowledge management. Three studies in three different settings have been conducted to date. The studies have provided multi-layered findings about social learning, and validated the use of ethnography for this purpose. Preliminary findings are discussed in this paper in terms of identified enablers and motivators for effective social learning and knowledge management. Although the paper deals with the defence environment, the findings can be generalised to other organisational settings, as the study deals with understanding the issues inherent in building sustainable and adaptive learning organisations.

Sex Differences in Social Interaction in Rats: Role of the Immediate-Early Gene zif268

OpenAIRE

Stack, Ashley; Carrier, Nicole; Dietz, David; Hollis, Fiona; Sorenson, Jamie; Kabbaj, Mohamed

2009-01-01

Given both the high prevalence of anxiety disorders in women and the fact that little is known about the mechanisms of gender differences in anxiety, our primary aim in this study was to investigate the neurobiological mechanisms underlying sex differences in social anxiety-like behavior in rats. Through the use of zif268 antisense oligodeoxynucleotides (zif ASO), we induced a temporary downregulation of zif268 expression in the medial prefrontal cortex of male and female rats and found that ...

The Impact of a Teaching-Learning Program Based on a Brain-Based Learning on the Achievement of the Female Students of 9th Grade in Chemistry

Science.gov (United States)

Shabatat, Kawthar; Al-Tarawneh, Mohammed

2016-01-01

This study aimed at recognizing the impact of teaching-learning program based on a brain-based learning on the achievement of female students of 9th grade in chemistry, to accomplish the goal of this study the researchers designed instruments of: instructional plans, pre achievement and past achievement exams to use them for the study-validity and…

When Salespeople Harbor Negative Stereotypes of their Corporate Headquarters : How Harmful is it and How can it be Avoided

OpenAIRE

Homburg, Christian; Wieseke, Jan; Lukas, Bryan A.; Mikolon, Sven

2011-01-01

This study examines the performance implications that organizations may suffer when their salespeople develop negative stereotypes of their corporate headquarters. How such stereotypes can be remedied through managerial action is also examined. The study draws on matched data from four different sources: sales managers, salespeople, customers, and company reports. Findings indicate that negative headquarters stereotypes among salespeople are associated with poor marketing-related performance ...

Usage of Metaphors in Turkish Language Textbooks Used at 6th, 7th and 8th Grades

Directory of Open Access Journals (Sweden)

Esra Karakas

2013-05-01

Full Text Available The word “Metaphor”, which is equivalent to the terms “istiare” in Arabic or “eğretileme, transfer of idioms” in Turkish, consists of two parts. “Meta” means “later” or “with” whereas “phora” means transfer or conveyance of word. In the recent years metaphor has been the subject and focuses of several studies, and is used to express a concept or situation with another concept or situation. Starting from 1980s, researchers have studied metaphor and concurrently they examined usage of language. It is now been believed that using metaphors is appropriate in order to be able to understand any phenomenon. Metaphor can be used in encouraging learning and improving creative thinking; it can also provide hints for in-the-class methods, techniques and situations. In this context, metaphors are also essential components for Turkish language textbooks. The purpose of this study is to detect the uses of metaphor in Turkish language textbooks of 6th, 7th and 8th grade students. For this purpose the Turkish language textbooks of 6th, 7th and 8th grade students prepared by the Ministry of National Education (MEB were examined with “content analysis method. Considering that metaphors are effective in learning and improving creative thinking, the importance of using metaphors in textbooks is beyond discussion. The data collected throughout this study show that the metaphors detected in 7th and 8th grade Turkish language textbooks are less in number compared to those found in 6th grade Turkish language textbooks. Another important conclusion is that distribution of metaphors among units is not even. The conclusion of the study is that Turkish language textbooks are not prepared in a sensitive and choosy manner with this respect.

Commemorating Toxicology at the National Institute of Environmental Health Sciences on the Occasion of Its 50th Anniversary

Science.gov (United States)

Bucher, John R.; Birnbaum, Linda S.

2016-01-01

Summary: In 1978, the National Toxicology Program (NTP) was established and headquartered at the National Institute of Environmental Health Sciences (NIEHS) in Research Triangle Park, North Carolina. On the occasion of the 50th Anniversary of the NIEHS, this article documents some of the historical and current NTP programs and scientific advances that have been made possible through this long-standing relationship. PMID:27801649

The Effect on the 8th Grade Students' Attitude towards Statistics of Project Based Learning

Science.gov (United States)

Koparan, Timur; Güven, Bülent

2014-01-01

This study investigates the effect of the project based learning approach on 8th grade students' attitude towards statistics. With this aim, an attitude scale towards statistics was developed. Quasi-experimental research model was used in this study. Following this model in the control group the traditional method was applied to teach statistics…

Implementation of Gasing Learning in ARCS Learning Strategy to Enhance Students’ Motivation in 9th Grade of Indonesian Junior High-School

Directory of Open Access Journals (Sweden)

Pri Ariadi Cahya Dinata

2017-10-01

Full Text Available The lack of motivation will affect to the students’ learning outcomes. The research was conducted to enhance the students’ motivation with the Gasing learning in the ARCS learning strategy on the static and dynamic electricity. The specific objectives of this research was to describe effect of the gasing learning on the students' learning motivation. The research consisted of 3 cycles of Hopkin’s Classroom Action Research  Model. Each cycle consists of the plan, the action/the observation, and the reflective. The data of students learning motivation obtained by questionnaires and be analyzed with method of successive interval (MSI. The findings of the research are: (1 the result of questionnaire of ARCS motivation in cycle I was 3.71, cycle II was 3,80, and cycle III was 3,99. These results indicate an increase in student learning motivation; (2 The completeness of students’ learning outcomes in cycle I was 68,18%, in cycle II was 90,90%, and in cycle III was 100%. It can be concluded that the Gasing learning in ARCS strategy can enhances students’motivation on static and dinamic electricity in 9th grade of Indonesian Junior High-School. The Gasing learning can be an alternative for the teachers to enhance students’ motivation in learning physics through the provision of comic media and calculations without formulas.

Spatial Visualization as Mediating between Mathematics Learning Strategy and Mathematics Achievement among 8th Grade Students

Science.gov (United States)

Rabab'h, Belal; Veloo, Arsaythamby

2015-01-01

Jordanian 8th grade students revealed low achievement in mathematics through four periods (1999, 2003, 2007 & 2011) of Trends in International Mathematics and Science Study (TIMSS). This study aimed to determine whether spatial visualization mediates the affect of Mathematics Learning Strategies (MLS) factors namely mathematics attitude,…

Determination of the Relationship between 8th Grade Students Learning Styles and TIMSS Mathematics Achievement

Science.gov (United States)

Yilmaz, Gül Kaleli; Koparan, Timur; Hanci, Alper

2016-01-01

In this study, it is aimed to determination of the relationship between learning styles and TIMSS mathematics achievements of eighth grade students. Correlational research design that is one of the quantitative research methods, was used in this study. The sample of the research consists of 652 8th grade students 347 are male and 305 are female…

49 CFR 268.3 - Different phases of the Maglev Deployment Program.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Different phases of the Maglev Deployment Program... DEPLOYMENT PROGRAM Overview § 268.3 Different phases of the Maglev Deployment Program. (a) The Maglev... deadlines—based on the progress of the Maglev Deployment Program; grantees will be notified accordingly. (b...

News from IAEA Headquarters

International Nuclear Information System (INIS)

1966-01-01

Full text: Two more countries have joined the Agency - Panama and Jordan - bringing IAEA membership up to 96. Mr. Ginige Richard Walter de Silva (Ceylon) has been appointed Director of the Division of Conference and General Services of the Agency. Born in 1911 at Nugegeda, Ceylon, Mr. de Silva obtained his B.Sc. in Physics at London University and his M.A. in Physics and Mathematics at Cambridge University. He has had a long career in the Civil Service, mainly in the administrative, commercial and finance branches of government. Mr.de Silva took over from Mr. Arthur E. Barrett, Chief of the Conference and Engineering Services, who had been Acting Director of the Division for a long period of time, and who will be leaving the Agency later this year to take up work elsewhere. From the early days of IAEA in 1957, Mr. Barrett has been closely associated with the establishment of the Agency's temporary headquarters in Vienna. He has been in charge of the planning and design of the technical facilities for the various conference installations and responsible for the servicing of all the General Conference sessions since 1958. In fact, Mr. Barrett has played an essential part in the creation of the Vienna Congress Centre in the former Hofburg Imperial Palace. Educated at Cambridge and London Universities, Mr. Barrett has had some 35 years of public service, first in the BBC in London and subsequently with the United Nations in New York. (author)

News from IAEA Headquarters

Energy Technology Data Exchange (ETDEWEB)

NONE

1966-06-15

Full text: Two more countries have joined the Agency - Panama and Jordan - bringing IAEA membership up to 96. Mr. Ginige Richard Walter de Silva (Ceylon) has been appointed Director of the Division of Conference and General Services of the Agency. Born in 1911 at Nugegeda, Ceylon, Mr. de Silva obtained his B.Sc. in Physics at London University and his M.A. in Physics and Mathematics at Cambridge University. He has had a long career in the Civil Service, mainly in the administrative, commercial and finance branches of government. Mr.de Silva took over from Mr. Arthur E. Barrett, Chief of the Conference and Engineering Services, who had been Acting Director of the Division for a long period of time, and who will be leaving the Agency later this year to take up work elsewhere. From the early days of IAEA in 1957, Mr. Barrett has been closely associated with the establishment of the Agency's temporary headquarters in Vienna. He has been in charge of the planning and design of the technical facilities for the various conference installations and responsible for the servicing of all the General Conference sessions since 1958. In fact, Mr. Barrett has played an essential part in the creation of the Vienna Congress Centre in the former Hofburg Imperial Palace. Educated at Cambridge and London Universities, Mr. Barrett has had some 35 years of public service, first in the BBC in London and subsequently with the United Nations in New York. (author)

Inflammatory Th17 cells promote depression-like behavior in mice

Science.gov (United States)

Beurel, Eléonore; Harrington, Laurie E.; Jope, Richard S.

2012-01-01

Background Recognition of substantial immune-neural interactions is revising dogmas about their insular actions and revealing that immune-neural interactions can substantially impact CNS functions. The inflammatory cytokine interleukin-6 promotes susceptibility to depression and drives production of inflammatory T helper 17 (Th17) T cells, raising the hypothesis that in mouse models Th17 cells promote susceptibility to depression-like behaviors. Methods Behavioral characteristics were measured in male mice administered Th17 cells, CD4+ cells, or vehicle, and in RORγT+/GFP mice or male mice treated with RORγT inhibitor or anti-IL-17A antibodies. Results Mouse brain Th17 cells were elevated by learned helplessness and chronic restraint stress, two common depression-like models. Th17 cell administration promoted learned helplessness in 89% of mice in a paradigm where no vehicle-treated mice developed learned helplessness, and impaired novelty suppressed feeding and social interaction behaviors. Mice deficient in the RORγT transcription factor necessary for Th17 cell production exhibited resistance to learned helplessness, identifying modulation of RORγT as a potential intervention. Treatment with the RORγT inhibitor SR1001, or anti-IL-17A antibodies to abrogate Th17 cell function, reduced Th17-dependent learned helplessness. Conclusions These findings indicate that Th17 cells are increased in the brain during depression-like states, promote depression-like behaviors in mice, and specifically inhibiting the production or function of Th17 cells reduces vulnerability to depression-like behavior, suggesting antidepressant effects may be attained by targeting Th17 cells. PMID:23174342

Learning by Doing: Teaching Multimedia Journalism through Coverage of the 50th Anniversary of "Freedom Summer"

Science.gov (United States)

Pain, Paromita; Masullo Chen, Gina; Campbell, Christopher P.

2016-01-01

In-depth qualitative interviews with participants of a high school journalism workshop reveal that immersing students in coverage of a historically important news event enhances learning of multimedia journalism. Study explores how using a team-based approach to coverage of the 50th anniversary of "Freedom Summer," a key event in…

12 CFR 268.205 - Employment of aliens; Access to sensitive information.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Employment of aliens; Access to sensitive... Complaints § 268.205 Employment of aliens; Access to sensitive information. (a) Definitions. The definitions...— (i) A citizen or National of the United States, (ii) An alien who: (A) Meets the conditions set forth...

Classroom Organization and Teacher Stress Predict Learning Motivation in Kindergarten Children

Science.gov (United States)

Pakarinen, Eija; Kiuru, Noona; Lerkkanen, Marja-Kristiina; Poikkeus, Anna-Maija; Siekkinen, Martti; Nurmi, Jari-Erik

2010-01-01

This study examined the extent to which observed teaching practices and self-reported teacher stress predict children's learning motivation and phonological awareness in kindergarten. The pre-reading skills of 1,268 children were measured at the beginning of their kindergarten year. Their learning motivation and phonological awareness were…

A PRECISE PHYSICAL ORBIT FOR THE M-DWARF BINARY GLIESE 268

Energy Technology Data Exchange (ETDEWEB)

Barry, R. K.; Danchi, W. C. [NASA Goddard Space Flight Center, Laboratory for Exoplanets and Stellar Astrophysics, Code 667, Greenbelt, MD 20771 (United States); Demory, B.-O.; Segransan, D.; Di Folco, E.; Queloz, D.; Udry, S. [Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Forveille, T.; Delfosse, X.; Mayor, M.; Perrier, C. [Geneva Observatory, Geneva University, 51 Ch.des Maillettes, CH-1290 Versoix (Switzerland); Spooner, H. R. [University of Maryland, College Park, MD 20742 (United States); Torres, G. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02136 (United States); Traub, W. A., E-mail: Richard.K.Barry@nasa.gov [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States)

2012-11-20

We report high-precision interferometric and radial velocity (RV) observations of the M-dwarf binary Gl 268. Combining measurements conducted using the IOTA interferometer and the ELODIE and Harvard Center for Astrophysics RV instruments leads to a mass of 0.22596 {+-} 0.00084 M {sub Sun} for component A and 0.19230 {+-} 0.00071 M {sub Sun} for component B. The system parallax as determined by these observations is 0.1560 {+-} 0.0030 arcsec-a measurement with 1.9% uncertainty in excellent agreement with Hipparcos (0.1572 {+-} 0.0033). The absolute H-band magnitudes of the component stars are not well constrained by these measurements; however, we can place an approximate upper limit of 7.95 and 8.1 for Gl 268A and B, respectively. We test these physical parameters against the predictions of theoretical models that combine stellar evolution with high fidelity, non-gray atmospheric models. Measured and predicted values are compatible within 2{sigma}. These results are among the most precise masses measured for visual binaries and compete with the best adaptive optics and eclipsing binary results.

The Effect of Project Based Learning on the Statistical Literacy Levels of Student 8th Grade

Science.gov (United States)

Koparan, Timur; Güven, Bülent

2014-01-01

This study examines the effect of project based learning on 8th grade students' statistical literacy levels. A performance test was developed for this aim. Quasi-experimental research model was used in this article. In this context, the statistics were taught with traditional method in the control group and it was taught using project based…

Corporate Language and Implications for Organizational Learning

DEFF Research Database (Denmark)

Zølner, Mette

2013-01-01

is insufficient to leverage contextually specific and culturally embedded knowledge. This indicates the need for disentangling language and culture. The paper further argues for the need to go beyond national language to consider how prevailing kinds of corporate talk may curb headquarters potential for learning...... from cultural and contextual diversity....

Lessons Learned for Space Safety from the Fukushima Nuclear Power Plant Accident

Science.gov (United States)

Nogami, Manami; Miki, Masami; Mitsui, Masami; Kawada, Ysuhiro; Takeuchi, Nobuo

2013-09-01

On March 11 2011, Tohoku Region Pacific Coast Earthquake hit Japan and caused the devastating damage. The Fukushima Nuclear Power Station (NPS) was also severely damaged.The Japanese NPSs are designed based on the detailed safety requirements and have multiple-folds of hazard controls to the catastrophic hazards as in space system. However, according to the initial information from the Tokyo Electric Power Company (TEPCO) and the Japanese government, the larger-than-expected tsunami and subsequent events lost the all hazard controls to the release of radioactive materials.At the 5th IAASS, Lessons Learned from this disaster was reported [1] mainly based on the "Report of the Japanese Government to the IAEA Ministerial Conference on Nuclear Safety" [2] published by Nuclear Emergency Response Headquarters in June 2011, three months after the earthquake.Up to 2012 summer, the major investigation boards, including the Japanese Diet, the Japanese Cabinet and TEPCO, published their final reports, in which detailed causes of this accident and several recommendations are assessed from each perspective.In this paper, the authors examine to introduce the lessons learned to be applied to the space safety as findings from these reports.

10 CFR 719.42 - What types of field actions must be coordinated with Headquarters?

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false What types of field actions must be coordinated with Headquarters? 719.42 Section 719.42 Energy DEPARTMENT OF ENERGY CONTRACTOR LEGAL MANAGEMENT REQUIREMENTS... adverse decisions, where legal issues of first impression, sensitive issues, issues of significance to the...

40 CFR 268.9 - Special rules regarding wastes that exhibit a characteristic.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Special rules regarding wastes that... (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS General § 268.9 Special rules regarding wastes that exhibit a characteristic. (a) The initial generator of a solid waste must determine each EPA...

The Effect of Process Oriented Guided Inquiry Learning (POGIL) on 11th Graders' Conceptual Understanding of Electrochemistry

Science.gov (United States)

Sen, Senol; Yilmaz, Ayhan; Geban, Ömer

2016-01-01

The purpose of this study was to investigate the effect of Process Oriented Guided Inquiry Learning (POGIL) method compared to traditional teaching method on 11th grade students' conceptual understanding of electrochemistry concepts. Participants were 115 students from a public school in Turkey. Nonequivalent control group design was used. Two…

49 CFR 268.5 - Federal funding sources for the Maglev Deployment Program.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Federal funding sources for the Maglev Deployment... TECHNOLOGY DEPLOYMENT PROGRAM Overview § 268.5 Federal funding sources for the Maglev Deployment Program. (a) Federal Maglev Funds. Section 322 of Title 23 provides for the following funds for the Maglev Deployment...

IAEA consultants' meeting: 9th meeting of atomic and molecular data centres and ALADDIN network, Vienna, September 20 and 21, 1990

International Nuclear Information System (INIS)

Janev, R.K.

1990-11-01

This Summary Report contains the proceedings and the conclusions of the IAEA Consultants' Meeting: 9th Meeting of Atomic and Molecular Data Centres and ALADDIN Network, convened on September 20 and 21, 1990, at the IAEA Headquarters in Vienna. The Progress Reports of national atomic data centres and reports on the ALADDIN status and developments are also included as appendices to the present Report. (author). Refs, figs and tabs

The Impact of Headquarter and Subsidiary Locations on Multinationals' Effective Tax Rates

OpenAIRE

Kevin S. Markle; Douglas A. Shackelford

2013-01-01

We examine effective tax rates (ETRs) for 9,022 multinationals from 87 countries from 2006 to 2011. We find that, despite extensive investments in international tax avoidance, multinationals headquartered in Japan, the United States, and some high-tax European countries continue to face substantially higher worldwide taxes than their counterparts in havens and other less heavily taxed locations. Other findings include: (1) effective tax rates remained steady over the investigation period; (2)...

Unseen and Unheard? Women Managers and Organizational Learning

Science.gov (United States)

Martin, Lynn M.; Lord, Gemma; Warren-Smith, Izzy

2018-01-01

Purpose: This paper aims to use (in)visibility as a lens to understand the lived experience of six women managers in the headquarters of a large multinational organization in the UK to identify how "gender" is expressed in the context of organizational learning. Design/methodology/approach: The researchers take a phenomenological…

A Precise Physical Orbit For The M-Dwarf Binary Gliese 268

Science.gov (United States)

Barry, R. K.; Demory, B. -O.; Segransan, D.; Forveille, T.; Danchi, W. C.; Di Folco, E.; Queloz, D.; Spooner, H. R.; Torres, G.; Traub, W. A.;

Control and autonomy between headquarters and subsidiaries: a case study of a us multinational in Portugal

Directory of Open Access Journals (Sweden)

Manuel Portugal Ferreira

2013-11-01

Full Text Available The management of multinational corporations (MNCs is complicated by the dispersion of subsidiaries in different locations, and the need to organize the best solutions for control, coordination and independence of each subsidiary to leverage their contribution to the EMN. In this article, based on the case study of a U.S. MNC with a subsidiary in Portugal, we analyze the relationship between autonomy and control headquarters the Portuguese subsidiary. The study identifies the main reasons that determine the amount of control exercised over the subsidiary. We conclude that the centralization, formalization of processes and integration rules are essential to the maintenance of coordination and cooperation between headquarters and subsidiary. However, it is the performance of the subsidiary and its role, particularly as contributory network of subsidiaries, which seems to confine the relations of control-autonomy.

Corporate Language and Implications for Organizational Learning

DEFF Research Database (Denmark)

Zølner, Mette

2013-01-01

This paper explores empirically implications of language use for MNCs’ learning from subsidiaries. Drawing on sociolinguistic literature, the article argues that while employing a single corporate language facilitates quick and direct communication of explicit knowledge, such a language design...... is insufficient to leverage contextually specific and culturally embedded knowledge. This indicates the need for disentangling language and culture. The paper further argues for the need to go beyond national language to consider how prevailing kinds of corporate talk may curb headquarters potential for learning...

Ability Of Mathematical Reasoning in SMK 10th Grade with LAPS- Heuristic using Performance Assessment

Directory of Open Access Journals (Sweden)

Aulia Nur Arivina

2017-11-01

Full Text Available The purposes of this research are: (1 Test the learning with LAPS-Heuristic model using performance assessment on 10th grade of Trigonometry material is complete, (2 to test the difference of students' mathematical reasoning ability on 10th grade of Trigonometry material between the learning model of LAPS-Heuristic using performance assessment, LAPS-Heuristic learning model with Expository learning model, (3 test the ability of mathematical reasoning with learning model of LAPS-Heuristik on Trigonometry material of SMK on 10th grade using performance assessment is increase. This is a quantitative research. The population is students of 10th grade of SMK 10 Semarang academic year 2016/2017 and the subject of research is selected by clustering random sampling. The results show that (1 Learning by model LAPS-Heuristic using performance assessment on 10th grade of Trigonometry material is complete (2 there are differences in students' mathematical reasoning ability on 10th grade of Trigonometry materials between LAPS-Heuristic learning model using performance assessment, LAPS-Heuristic learning model, and Expository learning model, (3 The ability of mathematical reasoning with learning model of LAPS-Heuristic on Trigonometry material of SMK class X using performance assessment increased.

The missing dimension of knowledge transfer from subsidiaries to headquarters: The case of Oil and Gas companies in CEE region

Directory of Open Access Journals (Sweden)

Emil Velinov

2016-12-01

Full Text Available The paper identifies knowledge management determinants of knowledge transfer from subsidiaries to headquarters in the top Oil & Gas companies in Central and Eastern Europe as their level of innovations, internationalization and economic importance are emerging. The paper sheds a light not only on the process of knowledge transfer parent-subsidiary but via versa as it is critical in the 21st century for better adapting to specific business needs in certain geographical regions. Thus, this reversed knowledge from subsidiaries to headquarters is critical for the given business sector where the level of innovation and amount of R&D investments are enormous. The study argues that the reversed process of knowledge transfers from subsidiary to parent company is positively related to company performance and business diversification. Nowadays the knowledge formed in the subsidiaries of Multinational Corporations (MNCs is transferred to headquarters by investing in R&D centres, building new exploration and testing sites abroad. In the reversed knowledge transfer process we can identify main challenges, which are very critical to analyse and determine the exact process.

Status report on roadmap headquarters issue resolution activities

International Nuclear Information System (INIS)

1993-01-01

The Roadmap Project Office (RPO), under the Office of Planning (EM-14), continues to review headquarters (HQ) issues raised by the field in their roadmap documents. Currently, twenty-nine HQ issues are in the ''resolution'' process or are being defined for resolution. The resolution process involves an Environmental Restoration and Waste Management Program (EM) HQ person, the Action Officer (AO), as the leader in the resolution process. The RPO is responsible to EM-14 for reporting on the progress of issue resolution activities and also to provide contractor support to each Action Officer: the contractor support person is identifies as the Issue Resolution Facilitator (IF). Field contacts also are identified for each issue. This document provides current information on HQ issues actively in the ''resolution'' process or being defined for resolution. The issues are primarily institutional rather than technical and mainly involve regulatory, coordination, prioritization, policy and management concerns

Flextime: A Modified Work Force Scheduling Technique for Selected Headquarters Air Force Logistics Command Organizations.

Science.gov (United States)

Kimzey, Reed T.; Prince, Samuel M. O.

The thesis discusses the advantages and disadvantages of one work force scheduling technique--flextime. The authors were interested in determining if a flextime schedule could be put into effect in a governmental organization such as Headquarters Air Force Logistics Command (AFLC). The study objectives were to determine the feasibility,…

What Do We Know About Corporate Headquarters? A Review, Integration, and Research Agenda

OpenAIRE

Menz, Markus; Kunisch, Sven; Collis, David J.

2013-01-01

During the past five decades, scholars have studied the corporate headquarters (CHQ) - the multidivisional firm's central organizational unit. The purpose of this article is to review the diverse and fragmented literature on the CHQ and to identify the variables of interest, the dominant relationships, and the contributions. We integrate, for the first time, the existing knowledge of the CHQ into an organizing framework. Based on a synthesis of the literature, we identify major shortcomings a...

Demonstration Assessment of Light-Emitting Diode Parking Structure Lighting at U.S. Department of Labor Headquarters

Energy Technology Data Exchange (ETDEWEB)

Kinzey, Bruce R.; Myer, Michael

2013-03-01

This report documents a solid-state lighting (SSL) technology demonstration at the parking structure of the U.S. Department of Labor (DOL) Headquarters in Washington, DC, in which light-emitting diode (LED) luminaires were substituted for the incumbent high-pressure sodium (HPS) luminaires and evaluated for relative light quantity and performance. The demonstration results show energy savings of 52% from the initial conversion of HPS to the LED product. These savings were increased to 88% by using occupancy sensor controls that were ultimately set to reduce power to 10% of high state operation after a time delay of 2.5 minutes. Because of the relatively high cost of the LED luminaires at their time of purchase for this project (2010), the simple payback periods were 6.5 years and 4.9 years for retrofit and new construction scenarios, respectively. Staff at DOL Headquarters reported high satisfaction with the operation of the LED product.

DefenseLink.mil - Special Report - Soldiers Train with Non-lethal Weapons

Science.gov (United States)

Spc. Yevgeniy Popov, a chemical warfare specialist with Headquarters and Headquarters Company, 3rd warfare specialist with Headquarters and Headquarters Company, 3rd Special Troops Battalion, 3rd Brigade , center, a combat engineer with Company A, 3rd Special Troops Battalion, 3rd Brigade Combat Team, 10th

The Effectiveness of a Self Regulated Learning-Based Training Program on Improving Cognitive and Metacognitive EFL Reading Comprehension of 9th Graders with Reading Disabilities

Science.gov (United States)

Eissa, Mourad Ali

2015-01-01

The purpose of this study was to explore the effect of a self regulated learning intervention program on cognitive and metacognitive EFL reading comprehension of 9th graders with reading disabilities. The participants in this study were 40 9th Graders with reading disabilities, selected from two schools located in Baltim Educational Edara. A…

Will learning to solve one-step equations pose a challenge to 8th grade students?

Science.gov (United States)

Ngu, Bing Hiong; Phan, Huy P.

2017-08-01

Assimilating multiple interactive elements simultaneously in working memory to allow understanding to occur, while solving an equation, would impose a high cognitive load. Element interactivity arises from the interaction between elements within and across operational and relational lines. Moreover, operating with special features (e.g. negative pronumeral) poses additional challenge to master equation solving skills. In an experiment, 41 8th grade students (girls = 16, boys = 25) sat for a pre-test, attended a session about equation solving, completed an acquisition phase which constituted the main intervention and were tested again in a post-test. The results showed that at post-test, students performed better on one-step equations tapping low rather than high element interactivity knowledge. In addition, students performed better on those one-step equations that contained no special features. Thus, both the degree of element interactivity and the operation with special features affect the challenge posed to 8th grade students on learning how to solve one-step equations.

Technical Workshop on Remediation of Radioactive Contamination in Agriculture, IAEA Headquarters, Vienna, Austria, 17-18 October 2016

International Nuclear Information System (INIS)

2017-01-01

The year 2016 marks the fifth anniversary of the accident at the Fukushima Daiichi nuclear power plant (NPP) and the 30th anniversary of the accident at the Chernobyl NPP. A Technical Workshop on Remediation of Radioactive Contamination in Agriculture was coorganised by the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture and the National Agriculture and Food Research Organization of Japan (NARO) and held at the IAEA headquarters, Vienna, Austria from 17 to 18 October 2016. Over 100 experts from around the world participated in the event. All presentations and discussions focused on research results and practical experience from Japan and from countries affected by Chernobyl NPP accident. This event was a great success in promoting and sharing knowledge and experience related to remediation of radioactive contamination in food and agriculture. From an agricultural perspective, the impacts of these two major accidents are related to caesium radionuclides, specifically "1"3"7Cs, which is a relatively long lived isotope with a half-life of some thirty years. Research and technical efforts to remediate and ameliorate the impact of radioactivity on agricultural production aim to minimize and prevent contamination of foods and other commodities, and further to assist the social and economic recovery of affected rural communities by enabling sustainable production. However, these efforts are not widely appreciated outside the affected areas

Computational mediation as factor of motivation and meaningful learning in education of sciences of 9th grade: astronomy topics

Science.gov (United States)

Da Silva, F. M.; Furtado, W. W.

2012-10-01

The main purpose of this study was to analyze the contribution of using hypertext and pedagogic mediation in search of a Meaningful Learning Process in Sciences. We investigate the usage of hypertext in the teaching and learning methods of Astronomy modules. A survey was conducted with students from the 9th grade of Primary School of a public school in the city of Goiânia, Goiás in Brazil. We have analyzed the possibilities that hypermedia can offer in the teaching and learning process, using as reference David Ausubel's Theory of Meaningful Learning. The study was divided into four phases: application of an initial questionnaire on students, development of didactic material (hypertext), six classes held in a computer lab with the use of hypermedia and a final questionnaire applied in the lab after classes. This research indicated that the use of hypertext linked to pedagogical mediation processes is seen as a motivational tool and has potential to foster to Meaningful Learning.

IAEA technical committee meeting: 11th meeting of the IFRC subcommittee on atomic and molecular data for fusion. Summary report

International Nuclear Information System (INIS)

Janev, R.K.

1999-05-01

Brief description of the proceedings, conclusions and recommendations of the 11th Meeting of the Subcommittee on Atomic, Molecular (A+M) and Plasma-Material Interaction (PMI) Data for Fusion of the IAEA International Fusion Research Council (IFRC), held on May 3-4, 1999, at the IAEA Headquarters in Vienna, Austria, is provided. The report includes also the Executive Summary from the meeting and is appended with the Report on Activities of IAEA A+M/PMI Data Unit for the period May 1998 - May 1999. (author)

IAEA technical committee meeting: 12th meeting of the IFRC Subcommittee on Atomic and Molecular Data for Fusion. Summary report

Energy Technology Data Exchange (ETDEWEB)

Clark, R E.H. [International Atomic Energy Agency, Vienna (Austria)

2000-12-01

This report briefly describes the proceedings, conclusions and recommendations of the 12th Meeting of the Subcommittee on Atomic and Molecular Data for Fusion of the International Fusion Research Council held on May 8-9, 2000 at the IAEA Headquarters in Vienna Austria. The report includes the Executive Summary of the Subcommittee from this Meeting which was communicated to the IAEA Director General as well as the report on the activities of the IAEA Atomic and Molecular Data Unit for the period June 1999 - May 2000. (author)

It participates in the 97th learning lecture, social meeting; Dai 97 kai Gakujitsu koenkai{center_dot}konshinkai ni sankashite

Energy Technology Data Exchange (ETDEWEB)

Maruta, T.; Moriya, M.; Izumi, K.

1999-01-01

An inorganic material academic meeting the 97th learning lecture, a social meeting and a study tour meeting were held for both days of (Thu) for 5 days in November 4 (Wed), the 10th year of Heisei. Contents of a lecture go into the large area to the thing that that method analysis technique structure analysis formation response thing materiality side was examined, the spot in the construction, building field like contents. A problem such as CO{sub 2} is an especially important problem as a negative legacy due to the industrial development, the diffusion of the car, and so on. (NEDO)

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (13th, Budapest, Hungary, April 10-12, 2017)

Science.gov (United States)

Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.

2017-01-01

These proceedings contain the papers and posters of the 13th International Conference on Mobile Learning 2017, which was organised by the International Association for Development of the Information Society (IADIS), in Budapest, Hungary, April 10-12, 2017. The Mobile Learning 2017 Conference seeks to provide a forum for the presentation and…

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (11th, Madeira, Portugal, March 14-16, 2015)

Science.gov (United States)

Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.

2015-01-01

These proceedings contain the papers and posters of the 11th International Conference on Mobile Learning 2015, which was organised by the International Association for Development of the Information Society, in Madeira, Portugal, March 14-16, 2015. The Mobile Learning 2015 Conference seeks to provide a forum for the presentation and discussion of…

Modeling of Teaching 5th-7th-Grade Boys Physical Exercises

Directory of Open Access Journals (Sweden)

Т. Г. Абдулхалікова

2017-09-01

Full Text Available The research objective is to determine the effectiveness of orthogonal variants of teaching 5th-7th graders physical exercises. Materials and methods. The participants in the research were boys of the 5th grade (n = 32, 6th grade (n = 40, 7th grade (n = 52. To achieve the tasks set, the research used the following methods: analysis of scientific and methodological literature; pedagogical testing, pedagogical observation, timing of educational tasks; pedagogical experiment, medical and biological research methods; methods of mathematical statistics, methods of mathematical experiment planning. In order to achieve the objective set, the research has studied the effect of different variants of the educational process structure, namely: the number of repetitions (х1 and rest intervals (х2 when learning the technique of performing physical exercises. The research has conducted a complete factor experiment of type 22. According to the experiment plan, the 5th-7th graders were divided into training groups. In total, there were 12 experimental groups organized. Research results. The analysis of the regression equations shows that the teaching of physical exercises to the 5th-7th-grade boys is mostly influenced by rest intervals between repetitions (х2. The number of repetitions (х1 has somewhat less influence. The interaction of these factors is insignificant when teaching physical exercises and becomes much more influential only when teaching a switch leg pull-over exercise (х1х2. Conclusions. To increase the effectiveness of teaching 5th-7th graders physical exercises, it is necessary to shorten rest intervals between repetition to 60 s and to reduce the number of repetitions to six. When teaching boys the switch leg pull-over exercise, rest intervals should be increased to 120 s and the number of repetitions — to twelve.

Viral-mediated Zif268 expression in the prefrontal cortex protects against gonadectomy-induced working memory, long-term memory, and social interaction deficits in male rats.

Science.gov (United States)

Dossat, Amanda M; Jourdi, Hussam; Wright, Katherine N; Strong, Caroline E; Sarkar, Ambalika; Kabbaj, Mohamed

2017-01-06

In humans, some males experience reductions in testosterone levels, as a natural consequence of aging or in the clinical condition termed hypogonadism, which are associated with impaired cognitive performance and mood disorder(s). Some of these behavioral deficits can be reversed by testosterone treatment. Our previous work in rats reported that sex differences in the expression of the transcription factor Zif268, a downstream target of testosterone, within the medial prefrontal cortex (mPFC) mediates sex differences in social interaction. In the present study, we aimed to examine the effects of gonadectomy (GNX) in male rats on mPFC Zif268 expression, mood and cognitive behaviors. We also examined whether reinstitution of Zif268 in GNX rats will correct some of the behavioral deficits observed following GNX. Our results show that GNX induced a downregulation of Zif268 protein in the mPFC, which was concomitant with impaired memory in the y-maze and spontaneous object recognition test, reduced social interaction time, and depression-like behaviors in the forced swim test. Reinstitution of mPFC Zif268, using a novel adeno-associated-viral (AAV) construct, abrogated GNX-induced working memory and long-term memory impairments, and reductions in social interaction time, but not GNX-induced depression-like behaviors. These findings suggest that mPFC Zif268 exerts beneficial effects on memory and social interaction, and could be a potential target for novel treatments for behavioral impairments observed in hypogonadal and aged men with declining levels of gonadal hormones. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

33 CFR 334.720 - Gulf of Mexico, south from Choctawhatchee Bay; guided missiles test operations area, Headquarters...

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Mexico, south from..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.720 Gulf of Mexico, south from Choctawhatchee Bay; guided missiles test operations area, Headquarters Air Proving...

76 FR 67671 - Agenda and Notice of Public Meeting of the Connecticut, District of Columbia, Maine, Maryland...

Science.gov (United States)

2011-11-02

....S.T.). The briefing will be at Commission Headquarters, 624 9th Street NW., Room 540, Washington, DC... are unable to attend the briefing at the Commission Headquarters in person may join through an... Eastern Regional Office, 624 9th Street NW., Suite 740, Washington, DC 20425. Persons wishing to email...

40 CFR 268.32 - Waste specific prohibitions-Soils exhibiting the toxicity characteristic for metals and...

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Waste specific prohibitions-Soils... Prohibitions on Land Disposal § 268.32 Waste specific prohibitions—Soils exhibiting the toxicity characteristic... from land disposal: any volumes of soil exhibiting the toxicity characteristic solely because of the...

IAEA technical committee meeting: 10th meeting of the IFRC subcommittee on atomic and molecular data for fusion. Summary report

Energy Technology Data Exchange (ETDEWEB)

Janev, R K

1999-01-01

This report describes briefly the proceedings and the conclusions and recommendations of the 10th Meeting of the Subcommittee on Atomic and Molecular Data for Fusion of the International Fusion Research Council held on May 27-28, 1998 at the IAEA Headquarters in Vienna, Austria. The report includes also the Executive Summary of the Subcommittee from this Meeting which was communicated to the IAEA Director General, and is appended with the Report on Activities of IAEA A+M Data Unit for the period July 1996 - May 1998. (author)

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (12th, Vilamoura, Algarve, Portugal, April 9-11, 2016)

Science.gov (United States)

Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.

2016-01-01

These proceedings contain the papers of the 12th International Conference on Mobile Learning 2016, which was organized by the International Association for Development of the Information Society, in Vilamoura, Algarve, Portugal, April 9-11, 2016. The Mobile Learning 2016 Conference seeks to provide a forum for the presentation and discussion of…

IAEA International Database on Irradiated Nuclear Graphite Properties. 7th meeting of the Technical Steering Committee

International Nuclear Information System (INIS)

Humbert, D.; Wickham, A.J.

2005-06-01

This report summarizes the Consultant Meeting '7th Meeting of the Technical Steering Committee for the International Database on Irradiated Nuclear Graphite Properties' held on 16-17 March 2005 at the IAEA Headquarters, Vienna, Austria. The purposes of the meeting were to review the matters and actions identified in the previous meeting, undertake a review of the current status of the database and to make recommendations for actions for the next year. The purposes of the meeting were fully met. This report contains the current status of the identified actions as well as a summary of the recommendations on enhancements to the database. (author)

iMindMap as an Innovative Tool in Teaching and Learning Accounting: An Exploratory Study

Science.gov (United States)

Wan Jusoh, Wan Noor Hazlina; Ahmad, Suraya

2016-01-01

Purpose: The purpose of this study is to explore the use of iMindMap software as an interactive tool in the teaching and learning method and also to be able to consider iMindMap as an alternative instrument in achieving the ultimate learning outcome. Design/Methodology/Approach: Out of 268 students of the management accounting at the University of…

3D Visualization Types in Multimedia Applications for Science Learning: A Case Study for 8th Grade Students in Greece

Science.gov (United States)

Korakakis, G.; Pavlatou, E. A.; Palyvos, J. A.; Spyrellis, N.

2009-01-01

This research aims to determine whether the use of specific types of visualization (3D illustration, 3D animation, and interactive 3D animation) combined with narration and text, contributes to the learning process of 13- and 14- years-old students in science courses. The study was carried out with 212 8th grade students in Greece. This…

Controls Over Materiel Procured for Direct Vendor Delivery

Science.gov (United States)

1995-02-10

National Guard, Company D, 560th Engineer Battalion, Bainbridge, GA Army National Guard, Company E, 121st Infantry Battalion, Tifton , GA Joint...Command, Fort Monmouth, NJ United States Army Forces Command, Atlanta, GA United States Army Materiel Command, Alexandria, VA United States Army...Fort Gillem, GA Headquarters, Fort Lee, Petersburg, VA Headquarters, Fort Riley, KS Headquarters, National Guard Bureau, Washington, DC Headquarters

Ability Of Mathematical Reasoning in SMK 10th Grade with LAPS- Heuristic using Performance Assessment

OpenAIRE

Aulia Nur Arivina; Masrukan Masrukan; Ardhi Prabowo

2017-01-01

The purposes of this research are: (1) Test the learning with LAPS-Heuristic model using performance assessment on 10th grade of Trigonometry material is complete, (2) to test the difference of students' mathematical reasoning ability on 10th grade of Trigonometry material between the learning model of LAPS-Heuristic using performance assessment, LAPS-Heuristic learning model with Expository learning model, (3) test the ability of mathematical reasoning with learning model of LAPS-Heuristik o...

About architecture of The Headquarters Building of the First Danube Steamboat Shipping Company in Belgrade

Directory of Open Access Journals (Sweden)

Drljević Marija

2007-01-01

Full Text Available In this work is represented history and described architecture of The Headquarters Building of The First Danube Steamboat Shipping Company in Belgrade. There is a close regard on the earlier research. The work is as well characterized by the attempt to determine architectural style of building with suggestion that it is a combination of a pure modernism with influences of architecture of communal houses in Vienna from 1919 to 1934.

Learning design guided learning analytics in MOOCs

NARCIS (Netherlands)

Brouns, Francis; Firssova, Olga

2016-01-01

Poster presentation for our paper Brouns, F., & Firssova, O. (2016, October).The role of learning design and learning analytics in MOOCs. Paper presented at 9th EDEN Research Workshop, Oldenburg, Germany.

Seamless learning: Technology-enhanced learning from practical experiences across contexts

NARCIS (Netherlands)

Rusman, Ellen

2018-01-01

Rusman, E. (2018, 8th of June). Seamless learning: Technology-enhanced learning from practical experiences across contexts. Keynote presentation at the Seamless learning conference, Maastricht, The Netherlands. http://www.ou.nl/slc

The Impact of Instructional Design on College Students' Cognitive Load and Learning Outcomes in a Large Food Science and Human Nutrition Course

Science.gov (United States)

Andrade, Jeanette; Huang, Wen-Hao David; Bohn, Dawn M.

2015-01-01

The effective design of course materials is critical for student learning, especially for large lecture introductory courses. This quantitative study was designed to explore the effect multimedia and content difficulty has on students' cognitive load and learning outcomes. College students (n = 268) were randomized into 1 of 3 multimedia groups:…

The Effect of the Conceptual Change Oriented Instruction through Cooperative Learning on 4th Grade Students' Understanding of Earth and Sky Concepts

Science.gov (United States)

Celikten, Oksan; Ipekcioglu, Sevgi; Ertepinar, Hamide; Geban, Omer

2012-01-01

The purpose of this study was to compare the effectiveness of the conceptual change oriented instruction through cooperative learning (CCICL) and traditional science instruction (TI) on 4th grade students' understanding of earth and sky concepts and their attitudes toward earth and sky concepts. In this study, 56 fourth grade students from the…

Determination of specific activities of U-238, Ra-226, Ra-228 e Th-228 in samples of mineral fertilizers with phosphorus

International Nuclear Information System (INIS)

Garcez, R.W.D.; Lopes, J.M.; Silva, A.X. da

2016-01-01

Samples were analyzed by gamma spectrometry mineral fertilizers with the HPGe detector and aid LabSOCS software for calculating the detection efficiency curve. Specific activities found for Pa-234m, Ra-226, Ra-228 and Th-228 in samples of phosphate fertilizers were 505 Bq.kg"-"1, 458 Bq.kg"-"1, 450 Bq.kg"-"1 and 394 Bq.kg"-"1, respectively. And for the NPK fertilizer samples were found average values of 390 Bq.kg"-"1, 252 Bq.kg"-"1, 280 Bq.kg"-"1 and 268 Bq.kg"-"1, respectively. (author)

Determination of specific activities of U-238, Ra-226, Ra-228 e Th-228 in samples of mineral fertilizers with phosphorus; Determinacao das atividades especificas de U-238, Ra-226, Ra-228 e Th-228 em amostras de fertilizantes minerais com fosforo

Energy Technology Data Exchange (ETDEWEB)

Garcez, R.W.D.; Lopes, J.M.; Silva, A.X. da, E-mail: rgarcez@nuclear.ufrj.br [Coordenacao dos Programas de Pos-Graduacao em Engenharoa (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear; Domingues, A.M.; Lima, M.A.F. [Universidade Federal Fluminense (UFF),Niteroi, RJ (Brazil)

2016-07-01

Samples were analyzed by gamma spectrometry mineral fertilizers with the HPGe detector and aid LabSOCS software for calculating the detection efficiency curve. Specific activities found for Pa-234m, Ra-226, Ra-228 and Th-228 in samples of phosphate fertilizers were 505 Bq.kg{sup -1}, 458 Bq.kg{sup -1}, 450 Bq.kg{sup -1} and 394 Bq.kg{sup -1}, respectively. And for the NPK fertilizer samples were found average values of 390 Bq.kg{sup -1}, 252 Bq.kg{sup -1}, 280 Bq.kg{sup -1} and 268 Bq.kg{sup -1}, respectively. (author)

An Exploratory Study of 4th, 5th, and 6th Grade Summer Camp Participants’ Attitudes and Intentions Towards Physical Activity

Directory of Open Access Journals (Sweden)

Melissa Cater

2015-10-01

Full Text Available Physical inactivity is a growing problem among children, particularly school-aged youth. Research suggests children are especially prone to inactivity in the summer months when access to structured school-time and extra-curricular activities is reduced. Community programs like residential summer camps offer an excellent environment for engaging children in enjoyable physical activities while also helping them learn to be more physically active when they return home. Pre-existing attitudes often influence how much change a program inspires in an individual. The purpose of this study was to explore 4th, 5th, and 6th grade summer camp participants’ attitudes towards physical activity. Results of this study indicate that youth have a fairly neutral, though positive, attitude towards physical activity and that parental support of physical activity is still extremely important, even at this age. Campers also indicated relatively high intentions to remain physically active in the two weeks after the camp ended

Challenges in Strategy and Management of Multinational R&D Centers in Emerging Markets: Perspective from a German Headquarters in the Chemical Sector

Directory of Open Access Journals (Sweden)

Osmar Mitsuo Saito

2013-03-01

Full Text Available The expansion of multinational company (MNCs operations abroad represents an observed trend for decades. The news is that in recent years the research and development (R&D activities also have become internationalized, including more intensified focus on emerging countries. Among the implications is the challenge for the MNCs to implement effective organizational structures with the intention to facilitate the articulated coordination of strategies and R&D management between the headquarters and their global R&D centers. The purpose of this study is to evaluate the strategy from the perspective of the corporate headquarters of a multinational company and the challenges in the formulation of the global R&D strategy and management of each center located inemerging and developed markets. For this reason, we developed an empirical research based on qualitative multiple case exploratory study in a German chemical MNC company in its five global R&D centers located in Germany (headquarters, USA, Brazil, China and India. The results suggested the needs to creation of organizational management capabilities for constant re-evaluation of its R&D strategy in order to capture the demands and the temporary windows of opportunities from these markets. These capabilities lead to reducing the strong observed centralization level and assigning more responsibilities to the subsidiaries with global R&D center status.

Transferring an Outcome-Oriented Learning Architecture to an IT Learning Game

NARCIS (Netherlands)

Schmitz, Birgit; Klemke, Roland; Totschnig, Michael; Czauderna, André; Specht, Marcus

2011-01-01

Schmitz, B., Klemke, R., Totschnig, M., Czauderna, A., & Specht, M. (2011, 23 September). Transferring an outcome-oriented learning architecture to an IT learning game. Presented at the 6th European conference on Technology enhanced learning: towards ubiquitous learning (EC-TEL 2011), Palermo,

80th Anniversary of Specola Vaticana in Castel Gandolfo : Internal Symposium

CERN Document Server

J, S; Eluo, Jean-Baptiste; SJ, SJ

2018-01-01

This book presents contributions from an internal symposium organized to celebrate the 80th anniversary of the Specola Vaticana, or Vatican Observatory, in the Papal Palace of Castel Gandolfo. The aim is to provide an overview of the scientific and cultural work being undertaken at the Observatory today and to describe the outcomes of important recent investigations. The contents cover interesting topics in a variety of areas, including planetary science and instrumentation, stellar evolution and stars, galaxies, cosmology, quantum gravity, the history of astronomy, and interactions between science, philosophy, and theology. On September 29, 1935, Pope Pius XI officially inaugurated the new headquarters of the Specola Vaticana at Castel Gandolfo. With new telescopes, a new astrophysical laboratory for spectrochemical analysis, and a young staff comprising Jesuit scientists, this inauguration marked the beginning of an intense period of scientific achievements at the Observatory. This anniversary book, featur...

25 CFR 26.8 - Where do I go to apply for Job Placement and Training assistance?

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Where do I go to apply for Job Placement and Training... PLACEMENT AND TRAINING PROGRAM General Applicability § 26.8 Where do I go to apply for Job Placement and Training assistance? You may apply for Job Placement and Training assistance at the servicing office...

5th Annual Pan-European Science and Big Physics Symposium on March 5th, 2012, Zurich, Switzerland

CERN Multimedia

Balle, Ch

2012-01-01

The 5th Annual Pan-European Science and Big Physics Symposium on March 5th is a technical workshop that covers topics in the areas of control, measurement and diagnostics for accelerators, cyclotrons, tokamaks and telescopes. The symposium brings together over 60 scientists and engineers from major research labs around the world such as CERN, PSI, INFN, NPL, ESRF and other research institutions. Attend this event to share ideas and results and to learn from the presentations of your peers from different labs and experiments worldwide.

IG Statement: Arthur A. Elkins, Jr., on OIG report Early Warning Report: Main EPA Headquarters Warehouse in Landover, Maryland, Requires Immediate EPA Attention

Science.gov (United States)

Statement of Inspector General Arthur A. Elkins, Jr., on the Office of Inspector General (OIG) report Early Warning Report: Main EPA Headquarters Warehouse in Landover, Maryland, Requires Immediate EPA Attention.

The Agency's permanent headquarters in the Donaupark

International Nuclear Information System (INIS)

1975-01-01

Early in 1967 the Government of Austria announced to the Board of Governors that it was making offers to the IAEA and UNIDO to establish Permanent Headquarters on 'the Donaupark site' to include office buildings, conference rooms required for the performance of the organizations' functions, as well as buildings for common services. The site of 160,000 square meters on the banks of the Danube River is 7 km from the centre of Vienna An International Architects' Competition was held in 1969. The Federal Government selected the plans of Architect Johann Staber in December 1970 and commissioned him with the work. A company, the IAKW (Internationales Amtssitzund Konferenzzentrum Wien AG), was founded in May 1971 and charged with the administrative, financial, and co-ordinating functions for the entire project. The construction of the office towers began in April 1973 and the shell of these towers was completed in the spring of 1975, the completed facades having already been placed on certain towers during that time. The conference building and the common services buildings are presently under construction. Completion of the whole complex is scheduled for the latter part of 1978 and work is progressing according to schedule. The actual building costs for the whole project are estimated at 6.8 billion Austrian schillings with an additional 6.2 billion schillings financing cost, and are shared between the Federal Government (65%) and the City of Vienna (35%); in addition, the City of Vienna has provided the land. Included in the total costs are the costs for traffic lanes within and leading to the area

Computer Assisted Language Learning (CALL): Using Internet for Effective Language Learning

NARCIS (Netherlands)

Kremenska, Anelly

2006-01-01

Please, cite this publication as: Kremenska, A. (2006). Computer Assisted Language Learning (CALL): Using Internet for Effective Language Learning. Proceedings of International Workshop in Learning Networks for Lifelong Competence Development, TENCompetence Conference. March 30th-31st, Sofia,

14th meeting of the IFRC Subcommittee on Atomic and Molecular Data for Fusion. Summary report of IAEA technical meeting

International Nuclear Information System (INIS)

Clark, R.E.H.; Peacock, N.J.

2006-01-01

The 14th Meeting of the Subcommittee on Atomic and Molecular Data for Fusion of the International Fusion Research Council was held on 24-25 June 2004, at the IAEA Headquarters in Vienna, Austria. Subcommittee members reviewed the work of the Atomic and Molecular Data Unit over the two-year period from June 2002 to June 2004, and made recommendations that covered the 2005-2006 budget cycle. The proceedings, conclusions and recommendations of the meeting are briefly described in this report, along with a short summary of the activities of the IAEA Atomic and Molecular Data Unit of the Nuclear Data Section from June 2002 to June 2004. (author)

An Analysis of the Relationship between the Learning Process and Learning Motivation Profiles of Japanese Pharmacy Students Using Structural Equation Modeling.

Science.gov (United States)

Yamamura, Shigeo; Takehira, Rieko

2018-04-23

Pharmacy students in Japan have to maintain strong motivation to learn for six years during their education. The authors explored the students’ learning structure. All pharmacy students in their 4th through to 6th year at Josai International University participated in the survey. The revised two factor study process questionnaire and science motivation questionnaire II were used to assess their learning process and learning motivation profiles, respectively. Structural equation modeling (SEM) was used to examine a causal relationship between the latent variables in the learning process and those in the learning motivation profile. The learning structure was modeled on the idea that the learning process affects the learning motivation profile of respondents. In the multi-group SEM, the estimated mean of the deep learning to learning motivation profile increased just after their clinical clerkship for 6th year students. This indicated that the clinical experience benefited students’ deep learning, which is probably because the experience of meeting with real patients encourages meaningful learning in pharmacy studies.

PV Performance Modeling Methods and Practices: Results from the 4th PV Performance Modeling Collaborative Workshop.

Energy Technology Data Exchange (ETDEWEB)

Stein, Joshua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-03-01

In 2014, the IEA PVPS Task 13 added the PVPMC as a formal activity to its technical work plan for 2014-2017. The goal of this activity is to expand the reach of the PVPMC to a broader international audience and help to reduce PV performance modeling uncertainties worldwide. One of the main deliverables of this activity is to host one or more PVPMC workshops outside the US to foster more international participation within this collaborative group. This report reviews the results of the first in a series of these joint IEA PVPS Task 13/PVPMC workshops. The 4th PV Performance Modeling Collaborative Workshop was held in Cologne, Germany at the headquarters of TÜV Rheinland on October 22-23, 2015.

Understanding the mechanism of atovaquone drug resistance in Plasmodium falciparum cytochrome b mutation Y268S using computational methods.

Directory of Open Access Journals (Sweden)

Bashir A Akhoon

Full Text Available The rapid appearance of resistant malarial parasites after introduction of atovaquone (ATQ drug has prompted the search for new drugs as even single point mutations in the active site of Cytochrome b protein can rapidly render ATQ ineffective. The presence of Y268 mutations in the Cytochrome b (Cyt b protein is previously suggested to be responsible for the ATQ resistance in Plasmodium falciparum (P. falciparum. In this study, we examined the resistance mechanism against ATQ in P. falciparum through computational methods. Here, we reported a reliable protein model of Cyt bc1 complex containing Cyt b and the Iron-Sulphur Protein (ISP of P. falciparum using composite modeling method by combining threading, ab initio modeling and atomic-level structure refinement approaches. The molecular dynamics simulations suggest that Y268S mutation causes ATQ resistance by reducing hydrophobic interactions between Cyt bc1 protein complex and ATQ. Moreover, the important histidine contact of ATQ with the ISP chain is also lost due to Y268S mutation. We noticed the induced mutation alters the arrangement of active site residues in a fashion that enforces ATQ to find its new stable binding site far away from the wild-type binding pocket. The MM-PBSA calculations also shows that the binding affinity of ATQ with Cyt bc1 complex is enough to hold it at this new site that ultimately leads to the ATQ resistance.

Determination of Motivation of 5th Grade Students Living in Rural and Urban Environments towards Science Learning and Their Attitudes towards Science-Technology Course

Science.gov (United States)

Kenar, Ismail; Köse, Mücahit; Demir, Halil Ibrahim

2016-01-01

In this research, determination of motivation of 5th grade students living in rural and urban environments towards science learning and their attitudes towards science-technology course is aimed. This research is conducted based on descriptive survey model. Samples are selected through teleological model in accordance with the aim of this…

17th Meeting of the IFRC Subcommittee on Atomic and Molecular Data for Fusion. Summary Report of an IAEA Technical Meeting

International Nuclear Information System (INIS)

Braams, B.J.

2012-06-01

The 17th meeting of the Subcommittee on Atomic and Molecular Data of the International Fusion Research Council (IFRC) was held on 27-28 April 2010 at IAEA Headquarters in Vienna, Austria. Activities of the Atomic and Molecular Data Unit for the period 2006-2008 were reviewed, and recommendations were made for the 2010-2011 budget cycle. The proceedings, conclusions and recommendations of the Subcommittee meeting are briefly described in this report. Specific recommendations of the Subcommittee from this meeting, as well as the report on the activities of the IAEA Atomic and Molecular Data Unit for the period May 2006 - March 2008, are also included. (author)

Summary report of consultants' meeting - IAEA International Database on Irradiated Nuclear Graphite Properties. 8th meeting of the Technical Steering Committee

International Nuclear Information System (INIS)

Humbert, D.; Wickham, A.J.

2006-05-01

The '8th Meeting of the Technical Steering Committee for the International Database on Irradiated Nuclear Graphite Properties' was held on 15-16 March 2006 at the IAEA Headquarters, Vienna, Austria. All discussions, recommendations and actions of this Consultants' Meeting are recorded in this report. The purposes of the meeting were to review the matters and actions identified in the previous meeting, undertake a review of the current status of the database and make recommendations for actions for the next year. This report contains the current status of the identified actions as well as a summary of the recommendations on enhancements to the database. (author)

An Investigation on Elementary School Students' Level of Math Learning, Using Math E-Books (A Case Study: Pishtazan Computer Primary School, 4th Zone of Tehran

Directory of Open Access Journals (Sweden)

Arezoo Naseri

2016-11-01

Full Text Available Since the focus on technology exists in all schools and classes, teachers need to know how to apply it in their teaching practices. The use of ICT in education is an undeniable necessity. Since the use of information and communication technology can smooth the paths of teaching-learning process for students, the researchers in this study tried to apply one of the information and communication technology tools, called electronic books (E-books in teaching math. The aim of this study is to examine elementary school students' level of math learning, using math e-books with the focus on teaching multiplication (Case Study: Pishtazan computer primary school, the 4th zone of Tehran. Using a quasi-experimental study, 61 third grade students from two primary schools for girls located in the 4th education zone of Tehran were selected. Math tests were used to collect data. Using T-test for independent samples, the results showed that level of math learning was higher in the students who have been trained with the help of e-book, compared to the students who have been trained through traditional teaching method.

Adaptive e-learning methods and IMS Learning Design. An integrated approach

NARCIS (Netherlands)

Burgos, Daniel; Specht, Marcus

2006-01-01

Please, cite this publication as: Burgos, D., & Specht, M. (2006). Adaptive e-learning methods and IMS Learning Design. In Kinshuk, R. Koper, P. Kommers, P. Kirschner, D. G. Sampson & W. Didderen (Eds.), Proceedings of the 6th IEEE International Conference on Advanced Learning Technologies (pp.

An Analysis of the Relationship between the Learning Process and Learning Motivation Profiles of Japanese Pharmacy Students Using Structural Equation Modeling

Directory of Open Access Journals (Sweden)

Shigeo Yamamura

2018-04-01

Full Text Available Pharmacy students in Japan have to maintain strong motivation to learn for six years during their education. The authors explored the students’ learning structure. All pharmacy students in their 4th through to 6th year at Josai International University participated in the survey. The revised two factor study process questionnaire and science motivation questionnaire II were used to assess their learning process and learning motivation profiles, respectively. Structural equation modeling (SEM was used to examine a causal relationship between the latent variables in the learning process and those in the learning motivation profile. The learning structure was modeled on the idea that the learning process affects the learning motivation profile of respondents. In the multi-group SEM, the estimated mean of the deep learning to learning motivation profile increased just after their clinical clerkship for 6th year students. This indicated that the clinical experience benefited students’ deep learning, which is probably because the experience of meeting with real patients encourages meaningful learning in pharmacy studies.

The Online Learning Knowledge Garden: A Pedagogic Planning Tool for e-Learning

NARCIS (Netherlands)

Scott, Bernard

2006-01-01

Please, cite this publication as: Scott, B. (2006). The Online Learning Knowledge Garden: A Pedagogic Planning Tool for e-Learning. Proceedings of International Workshop in Learning Networks for Lifelong Competence Development, TENCompetence Conference. March 30th-31st, Sofia, Bulgaria:

State Websites - The National Guard

Science.gov (United States)

, 5/19th Special Forces Group (A) Company B, 1-184th Infantry Regiment JFHQ, Headquarters and Brigade Combat Team (IBCT) 115th Regional Support Group 118th Maintenance Company 129th Rescue Wing 144th Fighter Wing 146th Airlift Wing 147th Combat Communications Squadron 149th Chemical Company 149th Combat

The E-learning Cabaret: do's and don'ts in E-Learning Design

NARCIS (Netherlands)

Westera, Wim

2009-01-01

Westera, W. (2006). The E-Learning Cabaret: do's and don'ts in E-Learning Design. Book of Abstracts, 12th International Conference on Technology Supported Learning & Teaching, Online Educa Berlin (pp. 169-171). November, 29-December, 1, 2006, Berlin, Germany: ICWE-GmbH.

Lifelong Learning: Concept, Policy, Instruments and Implementation

Directory of Open Access Journals (Sweden)

Metin TOPRAK

2012-01-01

Full Text Available European Union has started an education & training initiative under the umbrella of lifelong learning to achieve the 2020 Agenda targets. Th is initiative has nearly half of a century time horizon, and all designed policies and measures have been consolidated under this initiative. Turkish Education authorities have been monitoring this European eff ort closely and made important legal and institutional regulations in recent couple of years. Th is study examines the primary aspects of lifelong learning in detail: conceptual and philosophical background; recognition strategies; the place of formal, non-formal and informal learning in the lifelong learning approach; financing and measurement ways of lifelong learning; and variety of perspectives of international institutions. In addition, education and training strategy of the Europe’s 2020 vision of lifelong learning is also evaluated in detail. Th e human resources vision of the Europe considers education, occupation and economic activities together to allow authorities to plan the future of the European societies. Th e updating mechanisms of this approach are designed both domestically at national and internationally at European levels. It is concluded, in this study, that the lifelong learning policy and implementation of the Europe should be taken as benchmark.

Speech at the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instruction on Western Medicine Doctors Learning Traditional Chinese Medicine

Institute of Scientific and Technical Information of China (English)

CHEN Zhu

2009-01-01

@@ Respected leaders, distinguished guests, venerable seniors and comrades, Today, the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instructions on Western Medicine Doctors Learning Traditional Chinese Medicine was inaugurated by the Chinese Association of Integrative Medicine, and it is also an important occasion to review the past and look forward to the future.

Exploring Students' Conceptions of Science Learning via Drawing: A Cross-Sectional Analysis

Science.gov (United States)

Hsieh, Wen-Min; Tsai, Chin-Chung

2017-01-01

This cross-sectional study explored students' conceptions of science learning via drawing analysis. A total of 906 Taiwanese students in 4th, 6th, 8th, 10th, and 12th grade were asked to use drawing to illustrate how they conceptualise science learning. Students' drawings were analysed using a coding checklist to determine the presence or absence…

Validity of Students Worksheet Based Problem-Based Learning for 9th Grade Junior High School in living organism Inheritance and Food Biotechnology.

Science.gov (United States)

Jefriadi, J.; Ahda, Y.; Sumarmin, R.

2018-04-01

Based on preliminary research of students worksheet used by teachers has several disadvantages such as students worksheet arranged directly drove learners conduct an investigation without preceded by directing learners to a problem or provide stimulation, student's worksheet not provide a concrete imageand presentation activities on the students worksheet not refer to any one learning models curicullum recommended. To address problems Reviews these students then developed a worksheet based on problem-based learning. This is a research development that using Ploom models. The phases are preliminary research, development and assessment. The instruments used in data collection that includes pieces of observation/interviews, instrument self-evaluation, instruments validity. The results of the validation expert on student worksheets get a valid result the average value 80,1%. Validity of students worksheet based problem-based learning for 9th grade junior high school in living organism inheritance and food biotechnology get valid category.

Predicting the Attitudes and Self-Esteem of the Grade 9th Lower Secondary School Students towards Mathematics from Their Perceptions of the Classroom Learning Environment

Science.gov (United States)

Tran, Van Dat

2012-01-01

This study reports the validity of the hypothesis that students' perceptions of the learning environment of mathematics classroom may predict their attitudes and self-esteem towards mathematics. It examines data from 487 grade 9th students from 14 mathematics classes in 7 Vietnamese lower secondary schools to identify how students' perceptions of…

Using M@th Desktop Notebooks and Palettes in the Classroom

Science.gov (United States)

Simonovits, Reinhard

2011-01-01

This article explains the didactical design of M@th Desktop (MD), a teaching and learning software application for high schools and universities. The use of two types of MD resources is illustrated: notebooks and palettes, focusing on the topic of exponential functions. The handling of MD in a blended learning approach and the impact on the…

18th Meeting of the IFRC Subcommittee on Atomic and Molecular Data for Fusion. Summary Report of an IAEA Technical Meeting

International Nuclear Information System (INIS)

Braams, B.J.

2013-12-01

The 18th meeting of the Subcommittee on Atomic and Molecular Data of the International Fusion Research Council (IFRC) was held on 26-27 April 2012 at IAEA Headquarters in Vienna, Austria. Activities of the Atomic and Molecular Data Unit for the period 2010-2012 were reviewed and recommendations were made for continuig activitiees in 2012-2013 and for new projects in the 2014-2015 budget cycle. The proceedings, conclusions and recommendations of the Subcommittee meeting are briefly described in this report. Specific recommendations of the Subcommittee from this meeting, as well as the report on the activities of the IAEA Atomic and Molecular Data Unit for the period May 2010 - April 2012, are also included. (author)

Workshop on Learning Technology for Education in Cloud

CERN Document Server

Rodríguez, Emilio; Santana, Juan; Prieta, Fernando

2012-01-01

Learning Technology for Education in Cloud investigates how cloud computing can be used to design applications to support real time on demand learning using technologies. The workshop proceedings provide opportunities for delegates to discuss the latest research in TEL (Technology Enhanced Learning) and its impacts for learners and institutions, using cloud.   The Workshop on Learning Technology for Education in Cloud (LTEC '12) is a forum where researchers, educators and practitioners came together to discuss ideas, projects and lessons learned related to the use of learning technology in cloud, on the 11th-13th July at Salamanca in Spain.

The greening of the U.S. Department of Energy Headquarters, Washington, D.C. Second-year status report

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-04-22

The Greening of the Department of Energy Headquarters is a comprehensive, multi-year project designed to identify and implement specific actions DOE can take to save energy and money, improve the comfort and productivity of employees, and benefit the environment. It is part of the Administration`s overall effort to promote greening in all of the nation`s federal buildings. Present Clinton started the Greening of the White House in 1993, and similar efforts have been undertaken by the Department of Defense at the Pentagon, the National Park Service at the Presidio, and now the Department of Energy at the Forrestal and Germantown buildings. The Greening of the Department of Energy Headquarters, An Action Plan for Success (Action Plan), unveiled on April 22, 1996, outlined more than 80 action items for DOE`s Forrestal and Germantown buildings. The action items were designed to increase energy efficiency, improve resource management, improve air quality, reduce water use, reduce paper use, improve landscape management, improve maintenance and operational procedures, increase employee participation, and promote education and outreach. In the two years since the Action Plan was introduced, the Department of Energy has made major progress in implementing specific action items designed to target four major subject areas: (1) Energy Efficiency; (2) Resource Management; (3) Air, Water, Landscape, and (4) Human Factors. This report outlines the status of the recommendations of the Action Plan since they were introduced two years ago.

Effects of pre-natal X-ray exposure on learning behaviour of mice

International Nuclear Information System (INIS)

Frank, P.; Faber, U.; Budny, T.

1983-01-01

The authors investigated whether prenatal X-raying affects the learning behaviour of mice. For this purpose they irradiated mice of strain C57BL/6Ffm with 130 r at different points of the fetal phase. Unirradiated mice served as controls. The animals underwent two learning test series of 14 days each teaching them optical signs. The results of the test series show a distinctly inferior learning ability in the animals exposed to pre-natal irradiation as compared to unirradiated controls. The extent of the reduction of the learning ability depends on the stage of the pregnancy at the time of X-ray exposure. The greatest difference as compared to non-irradiated mice occurred in the animals irradiated at the earliest stage (13th/14th day of pregnancy). The results of the other test groups (15th/16th and 17th/18th day of pregnancy) exhibited less distinct, but still significant differences to the controls. Exposure at the latest period (17th/18th day) coincided with the smallest difference. (orig./MG) [de

The 9th international conference on computing and information technology

CERN Document Server

Unger, Herwig; Boonkrong, Sirapat; IC2IT2013

2013-01-01

This volume contains the papers of the 9th International Conference on Computing and Information Technology (IC2IT 2013) held at King Mongkut's University of Technology North Bangkok (KMUTNB), Bangkok, Thailand, on May 9th-10th, 2013. Traditionally, the conference is organized in conjunction with the National Conference on Computing and Information Technology, one of the leading Thai national events in the area of Computer Science and Engineering. The conference as well as this volume is structured into 3 main tracks on Data Networks/Communication, Data Mining/Machine Learning, and Human Interfaces/Image processing.  

The quality and impact of computer supported collaborative learning (CSCL) in radiology case-based learning

International Nuclear Information System (INIS)

Kourdioukova, Elena V.; Verstraete, Koenraad L.; Valcke, Martin

2011-01-01

Objective: The aim of this research was to explore (1) clinical years students' perceptions about radiology case-based learning within a computer supported collaborative learning (CSCL) setting, (2) an analysis of the collaborative learning process, and (3) the learning impact of collaborative work on the radiology cases. Methods: The first part of this study focuses on a more detailed analysis of a survey study about CSCL based case-based learning, set up in the context of a broader radiology curriculum innovation. The second part centers on a qualitative and quantitative analysis of 52 online collaborative learning discussions from 5th year and nearly graduating medical students. The collaborative work was based on 26 radiology cases regarding musculoskeletal radiology. Results: The analysis of perceptions about collaborative learning on radiology cases reflects a rather neutral attitude that also does not differ significantly in students of different grade levels. Less advanced students are more positive about CSCL as compared to last year students. Outcome evaluation shows a significantly higher level of accuracy in identification of radiology key structures and in radiology diagnosis as well as in linking the radiological signs with available clinical information in nearly graduated students. No significant differences between different grade levels were found in accuracy of using medical terminology. Conclusion: Students appreciate computer supported collaborative learning settings when tackling radiology case-based learning. Scripted computer supported collaborative learning groups proved to be useful for both 5th and 7th year students in view of developing components of their radiology diagnostic approaches.

The quality and impact of computer supported collaborative learning (CSCL) in radiology case-based learning.

Science.gov (United States)

Kourdioukova, Elena V; Verstraete, Koenraad L; Valcke, Martin

2011-06-01

The aim of this research was to explore (1) clinical years students' perceptions about radiology case-based learning within a computer supported collaborative learning (CSCL) setting, (2) an analysis of the collaborative learning process, and (3) the learning impact of collaborative work on the radiology cases. The first part of this study focuses on a more detailed analysis of a survey study about CSCL based case-based learning, set up in the context of a broader radiology curriculum innovation. The second part centers on a qualitative and quantitative analysis of 52 online collaborative learning discussions from 5th year and nearly graduating medical students. The collaborative work was based on 26 radiology cases regarding musculoskeletal radiology. The analysis of perceptions about collaborative learning on radiology cases reflects a rather neutral attitude that also does not differ significantly in students of different grade levels. Less advanced students are more positive about CSCL as compared to last year students. Outcome evaluation shows a significantly higher level of accuracy in identification of radiology key structures and in radiology diagnosis as well as in linking the radiological signs with available clinical information in nearly graduated students. No significant differences between different grade levels were found in accuracy of using medical terminology. Students appreciate computer supported collaborative learning settings when tackling radiology case-based learning. Scripted computer supported collaborative learning groups proved to be useful for both 5th and 7th year students in view of developing components of their radiology diagnostic approaches. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Self-regulated learning, self-efficacy beliefs and performance during the late childhood

Directory of Open Access Journals (Sweden)

Salmerón-Pérez, Honorio

2010-10-01

Full Text Available This article analyzes relations between self-regulated learning, self-efficacy beliefs, and performance in tasks of solving arithmetic problems. The research includes 268 six-year-old students enrolled in the first year of primary school in Spain. The results from binary logistic regression models indicate that self-regulated learning and its interaction with self-efficacy beliefs predict performance. Finally, the cluster analysis shows four profiles of students: i positive adjusted; ii negative unadjusted I; iii negative unadjusted II y; iv negative adjusted.. Este artículo analiza relaciones entre el aprendizaje autorregulado, las creencias de autoeficacia y el desempeño en tareas de resolución de problemas aritméticos. El estudio se ha llevado a cabo con 268 escolares de seis años de edad y matriculados en el primer año de educación primaria en España. Los resultados obtenidos mediante modelos de regresión logística binaria indican que el aprendizaje autorregulado y su interacción con las creencias de autoeficacia predicen el desempeño. Por último, la aplicación de un análisis Cluster muestra cuatro perfiles de escolares, denominados: i ajustado positivo; ii desajustado negativo I; iii desajustado negativo II y; iv ajustado negativo.

Florida creativity index scores, conservatism, and openness in 268 U.S. regions.

Science.gov (United States)

McCann, Stewart J H

2011-02-01

This study assessed whether Florida's Creativity Index (2002) scores for 268 U.S. regions were related to levels of conservatism and openness in the states in which the regions were situated. State conservatism was measured as the percentage voting for Bush in 2000. State openness z scores were taken from a survey of 619,397 residents (Rentfrow, Gosling, & Potter, 2008). Creativity scores correlated negatively with conservatism (r = -.22) and positively with openness (r = .23). Regression showed that the two predictors accounted jointly (7%) and separately for significant variance in the Creativity Index. The findings contribute evidence for the construct validity of Florida's composite Creativity Index and some, albeit moderate to weak, support of the Rentfrow, et al. conclusion that state-aggregated openness reflects the unconventionality, tolerance, and creativity of a state.

Reforming the 4th-Year Curriculum as a Springboard to Graduate Medical Training: One School's Experiences and Lessons Learned.

Science.gov (United States)

Wackett, Andrew; Daroowalla, Feroza; Lu, Wei-Hsin; Chandran, Latha

2016-01-01

Concerns regarding the quality of training in the 4th year of medical school and preparation of graduates to enter residency education persist and are borne out in the literature. We reviewed the published literature regarding Year 4 concerns as well as institutional efforts to improve the 4th-year curriculum from several schools. Based on input from key stakeholders, we established 4 goals for our Year 4 curriculum reform: (a) standardize the curricular structure, (b) allow flexibility and individualization, (c) improve the preparation for residency, and (d) improve student satisfaction. After the reform, we evaluated the outcomes using results from the Association of American Medical Colleges Questionnaire, student focus groups, and program director surveys. This article describes the context, process, and outcomes of the reform of the Year 4 curriculum at Stony Brook University School of Medicine. We were able to achieve all four stated goals for the reform. The significant components of the change included a flexible adaptable curriculum based on individual needs and preferences, standardized learning objectives across the year, standardized competency-based evaluations regardless of discipline, reinforcement of clinical skills, and training for the transition to the workplace as an intern. The reform resulted in increased student satisfaction, increased elective time, and increased preparedness for residency training as perceived by the graduates. The Program Director survey showed significant changes in ability to perform a medical history and exam, management of common medical conditions and emergencies, clinical reasoning and problem-solving skills, working and communication with the healthcare team, and overall professionalism in meeting obligations inherent in the practice of medicine. Lessons learned from our 4th-year reform process are discussed. Listening to the needs of the stakeholders was an important step in ensuring buy-in, having an institutional

Methodologies and intelligent systems for technology enhanced learning

CERN Document Server

Gennari, Rosella; Vitorini, Pierpaolo; Vicari, Rosa; Prieta, Fernando

2014-01-01

This volume presents recent research on Methodologies and Intelligent Systems for Technology Enhanced Learning. It contains the contributions of ebuTEL 2013 conference which took place in Trento, Italy, on September, 16th 2013 and of mis4TEL 2014 conference, which took take place in Salamanca, Spain, on September, 4th-6th 2014 This conference series are an open forum for discussing intelligent systems for Technology Enhanced Learning and empirical methodologies for its design or evaluation.

Zen of cloud learning cloud computing by examples on Microsoft Azure

CERN Document Server

Bai, Haishi

2014-01-01

Zen of Cloud: Learning Cloud Computing by Examples on Microsoft Azure provides comprehensive coverage of the essential theories behind cloud computing and the Windows Azure cloud platform. Sharing the author's insights gained while working at Microsoft's headquarters, it presents nearly 70 end-to-end examples with step-by-step guidance on implementing typical cloud-based scenarios.The book is organized into four sections: cloud service fundamentals, cloud solutions, devices and cloud, and system integration and project management. Each chapter contains detailed exercises that provide readers w

Report [of the] Expert Meeting on Intercultural Education, Section of Education for Peace and Human Rights (UNESCO Headquarters, Paris, March 20-22, 2006)

Science.gov (United States)

United Nations Educational, Scientific and Cultural Organization (UNESCO), 2006

2006-01-01

The Section of Education for Peace and Human Rights of the Division for the Promotion of Quality Education held an expert meeting on Intercultural Education from March 20-22, 2006 at UNESCO Headquarters, bringing together international experts from Australia, Bolivia, Egypt, Finland, Hungary, Korea, Lebanon, Mexico, Nigeria, South Africa and the…

Structuring mobile and contextual learning

NARCIS (Netherlands)

Glahn, Christian; Specht, Marcus

2011-01-01

Glahn, C., & Specht, M. (2011). Structuring mobile and contextual learning. In Proceedings of the 10th World Conference on Mobile and Contextual Learning (pp. 188-195). October, 18-21, 2011, Beijing, China.

The 26th Amendment and Youth Voting Rights.

Science.gov (United States)

Schamel, Wynell

1996-01-01

Describes learning activities to be used in conjunction with a facsimile of the 92nd Congress's joint resolution passing the 26th Amendment extending the voting franchise to 18-year-olds. These activities include document analysis, time lines, class discussions, and storytelling. Briefly reviews the amendment process. (MJP)

Public health and social supervision issues within public administration of ukrainian territories in the late 8th- early 9th centuries.

Science.gov (United States)

Hrynzovskyi, Anatolii M; Holovanova, Irina A; Omelchuk, Sergei T; Kuzminska, Olena V; Hrynzovska, Anastasia A; Karlova, Olena O; Kondratiuk, Vitalii Ye

Introduction: The public health system modernization history is based upon the progress in state country administration and administration of healthcare within the sectorwide approach. The WHO European Bureau pays much attention to the National Health Service systems development while implementing their basic policies. The Ukrainian state health service management was founded basing on the regulatory field of the Russian Empire, using the European healthcare promotion experience. Aim: of the article is the analysis of the regulatory field of police and amenity authorities of the Russian Empire and Ukraine within the medical and social service in the 18th-19th centuries. Materials and methods: The structure of the article corresponds to the problem city and chronology principles, using the following methods and techniques of scientific learning: the systemic, historic, regulatory comparative, logical and structural-functional analysis of the studied medical-legal phenomena. The study sources are the scientific publications, collections of laws and executive orders of the Russian Empire and Ukraine in the 18th-19th centuries. Review: As a result of the performed work it can be determined were the main directions of the police competence in late 18th- early 19th centuries. Conclusion: Preserving health, treatment of the ill and injured, management of medical and social service of those in need, holding various preventive activities and supporting safe environment and regulating the safety of food were the main directions of the police competence in late 18th- early 19th centuries.

Reactor physics activities in NEA member countries

International Nuclear Information System (INIS)

1990-01-01

This document is a compilation of National activity reports presented at the thirty-third Meeting of the NEA Committee on Reactor Physics, held at OECD Headquarters, Paris, from 15th - 19th October 1990

The Effect of Blended Learning and Social Media-Supported Learning on the Students' Attitude and Self-Directed Learning Skills in Science Education

Science.gov (United States)

Akgunduz, Devrim; Akinoglu, Orhan

2016-01-01

The main purpose of this study is to investigate the effect of blended learning and social media supported learning on the students' attitude and self-directed learning skills in Science Education. This research took place with the 7th grade 74 students attending to a primary school in Kadikoy, Istanbul and carried out "Our Body Systems"…

Lifelong Learning in Colombia and Denmark

DEFF Research Database (Denmark)

Olesen, Henning Salling

2004-01-01

The article examines education and learning opportunities in Colombia against the backdrop of Danish modernisation and reform experiences from second half of 20th Century. The article discusses possibilities to learn from Danish experiences in the development of a Colombian lifelong learning policy...

Observations of interstellar ultraviolet extinction from the S2/68 experiment in the TD-1 satellite

International Nuclear Information System (INIS)

Nandy, K.; Thompson, G.I.; Carnochan, D.J.; Wilson, R.

1978-01-01

The galactic distribution of the agents which cause the extinction bump near 2200 A and the ultraviolet colour excess E(1550-2740) within 2 kpc of the Sun in the galactic plane have been studied from the observations obtained with the S2/68 experiment in the TD-1 satellite. The mean reddening-distance relation in the galactic plane has been obtained for different longitudes. The study of the extinction parameter with galactic latitude shows a strong concentration of the dust towards the galactic plane with a scale height of 110 pc. (author)

Learning Perl Student Workbook

CERN Document Server

foy, brian

2012-01-01

This is an ebook-only workbook to accompany the 6th Edition of Learning Perl ("the Llama"). If you're just getting started with Perl, this is the book you want-whether you're a programmer, system administrator, or web hacker. This 6th edition of Learning Perl covers recent changes to the language up to version 5.14. Exercises are presented in the first half of the workbook, with the answers in the second. Topics include: Scalar DataLists and ArraysSubroutinesInput and OutputHashesIn the World of Regular ExpressionsMatching with Regular ExpressionsProcessing Text with Regular Expressions10.

6th International Symposium on Ambient Intelligence

CERN Document Server

Novais, Paulo; Pereira, António; González, Gabriel; Fernández-Caballero, Antonio

2015-01-01

This volume contains the proceedings of the 6th International Symposium on Ambient Intelligence (ISAmI 2015), held in Salamanca, Spain on June 3th-5th at the University of Salamanca. After a careful review, 27 papers from 10 different countries were selected to be presented in ISAmI 2015 at the conference and published in the proceedings.  ISAmI has been running annually and aiming to bring together researchers from various disciplines that constitute the scientific field of Ambient Intelligence to present and discuss the latest results, new ideas, projects and lessons learned, namely in terms of software and applications, and aims to bring together researchers from various disciplines that are interested in all aspects of this area. Ambient Intelligence is a recent paradigm emerging from Artificial Intelligence, where computers are used as proactive tools assisting people with their day-to-day activities, making everyone’s life more comfortable. Another main concern of AmI originates from the human comput...

AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for United States Coast Guard Headquarters

Energy Technology Data Exchange (ETDEWEB)

Schey, Stephen [Idaho National Lab. (INL), Idaho Falls, ID (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-05-01

Federal agencies are mandated to purchase alternative fuel vehicles, increase consumption of alternative fuels, and reduce petroleum consumption. Available plug-in electric vehicles (PEVs) provide an attractive option in the selection of alternative fuel vehicles. PEVs, which consist of both battery electric vehicles (BEVs) and plug-in hybrid electric vehicles (PHEVs), have significant advantages over internal combustion engine (ICE) vehicles in terms of energy efficiency, reduced petroleum consumption, and reduced production of greenhouse gas (GHG) emissions, and they provide performance benefits with quieter, smoother operation. This study intended to evaluate the extent to which the United States Coast Guard Headquarters (USCG HQ) could convert part or all of their fleet of vehicles from petroleum-fueled vehicles to PEVs.

The integrated learning management using the STEM education for improve learning achievement and creativity in the topic of force and motion at the 9th grade level

Science.gov (United States)

Kakarndee, Nampetch; Kudthalang, Nukool; Jansawang, Natchanok

2018-01-01

The aims of this research study were to investigate and analyze the processing performances and the performance results (E1/E2) efficiency at the determining criteria for planning students' improvements to their learning processes toward their scientific knowledge were investigated, carry out the investigations, gathering evidence, and proposing explanations were developed and predicted. Students' engagements to their needs in unambiguous and clearly content of science teaching onto the instructional processes were attempted for establishing a national approach with the STEM education instructional method were strategized. Research administrations were designed to a sample size consisted of 40 secondary students in science class at the 9th grade level in Borabu School with the purposive sampling technique was selected. Using the STEM Education instructional innovation's lesson plans were managed learning activities. Students' learning achievements were assessed with the Pre-Test and Post-Test designs of 30 items. Students' creative thinking abilities were determined of their perceptions that obtained of the 3-item Creative Thinking Ability Test. The results for the effectiveness of the innovative instructional lesson plans based on the STEM Education Method, the lessoning effectiveness (E1/E2) evidences of 78.95/76.58 over the threshold setting is 75/75. Pretest-posttest designs for assessing students' learning achievements that impact a student's ability to achieve and explains with the STEM education instructional method were differences, significantly (ρ<.001) and the posttest of the 3-item Creative Thinking Ability Test designs for assessing Students' creative thinking abilities that impact a student's ability to have a good skill level in originality, fluency and flexibility thinking with the STEM education instructional method were differences, significantly (ρ<.001).

E-Learning and Role of World Wide Web in E-Learning

OpenAIRE

Jahankhani, Hossein

2012-01-01

This paper reviews some of the aspects of the E-learning through the World Wide Web. E-revolution as new phenomenon influenced the society by its means and strategies. E-learning is one of the sub-products of E-revolution, towards making more convenient and effective learning. In time Internet become a source of information, people start to learn through the Internet instead of books. It gives the flexibility to remote access at any time. The working people and the students are inspired by th...

Scientific conference on the occasion of the 200th anniversary of the foundation of the Kraków Learned Society (in Polish

Directory of Open Access Journals (Sweden)

Tomasz Pudłocki

2016-11-01

Full Text Available The author submittedto print the report of the scientific conference which had been organized on the occasion of the 200th anniversary of the foundation of the Kraków Learned Society. The session was held in December 9–10, 2015 as a result of cooperation between the Polish Academy of Arts and Sciences, the Jagiellonian University as well as the Scientific Archives of the Polish Academy of Sciences and the Polish Academy of Arts and Sciences in Kraków. It brought an international group of speakers together to discuss in their deliberations the various aspects of the Cracow Learned Society. The outcome of the meeting is the publication Towarzystwo Naukowe Krakowskie w 200-lecie założenia (1815–2015. Materiały konferencji naukowej 9–10 grudnia 2015, edited by Wanda Lohman (Kraków, 2016.

Development of Scientific Approach Based on Discovery Learning Module

Science.gov (United States)

Ellizar, E.; Hardeli, H.; Beltris, S.; Suharni, R.

2018-04-01

Scientific Approach is a learning process, designed to make the students actively construct their own knowledge through stages of scientific method. The scientific approach in learning process can be done by using learning modules. One of the learning model is discovery based learning. Discovery learning is a learning model for the valuable things in learning through various activities, such as observation, experience, and reasoning. In fact, the students’ activity to construct their own knowledge were not optimal. It’s because the available learning modules were not in line with the scientific approach. The purpose of this study was to develop a scientific approach discovery based learning module on Acid Based, also on electrolyte and non-electrolyte solution. The developing process of this chemistry modules use the Plomp Model with three main stages. The stages are preliminary research, prototyping stage, and the assessment stage. The subject of this research was the 10th and 11th Grade of Senior High School students (SMAN 2 Padang). Validation were tested by the experts of Chemistry lecturers and teachers. Practicality of these modules had been tested through questionnaire. The effectiveness had been tested through experimental procedure by comparing student achievement between experiment and control groups. Based on the findings, it can be concluded that the developed scientific approach discovery based learning module significantly improve the students’ learning in Acid-based and Electrolyte solution. The result of the data analysis indicated that the chemistry module was valid in content, construct, and presentation. Chemistry module also has a good practicality level and also accordance with the available time. This chemistry module was also effective, because it can help the students to understand the content of the learning material. That’s proved by the result of learning student. Based on the result can conclude that chemistry module based on

Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells.

Science.gov (United States)

Duechting, Andrea; Przybyla, Anna; Kuerten, Stefanie; Lehmann, Paul V

2017-09-12

During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell repertoire is critical for immune monitoring purposes. Antigen-specific Th1, Th2, and Th17 cells can be detected by challenging peripheral blood mononuclear cells (PBMC) with antigen, and establishing the numbers of T cells producing the respective lead cytokine, IFN-γ and IL-2 for Th1 cells, IL-4 and IL-5 for Th2, and IL-17 for Th-17 cells, respectively. Traditionally, these cytokines are measured within 6 h in flow cytometry. We show here that 6 h of stimulation is sufficient to detect peptide-induced production of IFN-γ, but 24 h are required to reveal the full frequency of protein antigen-specific Th1 cells. Also the detection of IL-2 producing Th1 cells requires 24 h stimulation cultures. Measurements of IL-4 producing Th2 cells requires 48-h cultures and 96 h are required for frequency measurements of IL-5 and IL-17 secreting T cells. Therefore, accounting for the differential secretion kinetics of these cytokines is critical for the accurate determination of the frequencies and ratios of antigen-specific Th1, Th2, and Th17 cells.

Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance.

Science.gov (United States)

Chen, Xuemei; Wang, Junfu; Wang, Rui; Su, Qinghong; Luan, Junwen; Huang, Haiyan; Zhou, Peng; Liu, Jinsheng; Xu, Xiaoqun

2016-02-01

Th0 cells differentiate into Th1 or Th2 depending on multiple transcription factors acting on specific time points to regulate gene expression. Th17 cells, a subset of IL-17-producing T cells distinct from Th1 or Th2 cells, have been described as key players in inflammation and autoimmune diseases as well as cancer development. In the present study, 53 patients with hypopharyngeal cancer were included. The expression levels of Th1-, Th2- and Th17-associated cytokines in hypopharyngeal cancer tissues and pericarcinoma tissues were detected. The relationship between Th1, Th2, or Th17 infiltration and metastasis was studied. Our results showed that the mRNA and protein expressions of Th1 cytokines were lower, while the expressions of Th2 and Th17 cytokines were higher in tumor tissues, and the intensity of expression was strengthened with clinical stage increasing. Cancer tissues had higher level expressions of Th2 and Th17 cytokines than that of pericarcinoma tissues. From the above data, we speculated that high expressions of Th2- and Th17-associated cytokines in hypopharyngeal carcinoma may contribute to cancer development and metastasis.

Learning from prescribing errors

OpenAIRE

Dean, B

2002-01-01



 The importance of learning from medical error has recently received increasing emphasis. This paper focuses on prescribing errors and argues that, while learning from prescribing errors is a laudable goal, there are currently barriers that can prevent this occurring. Learning from errors can take place on an individual level, at a team level, and across an organisation. Barriers to learning from prescribing errors include the non-discovery of many prescribing errors, lack of feedback to th...

Texts of the Agency's Agreements with the Republic of Austria. A further supplemental agreement to the Headquarters Agreement. Supplemental Agreement pursuant to Section 4(b) of the Agreement between the Republic of Austria and the International Atomic Energy Agency regarding the Headquarters of the International Atomic Energy Agency

International Nuclear Information System (INIS)

1996-01-01

The text of the exchange of Notes, dated 6 July 1995 and 29 September 1995 respectively, between the IAEA and the Ministry of Foreign Affairs of Austria regarding Section 4(b) of the Headquarters Agreement which allows the IAEA 'to establish and operate such additional radio and other telecommunications facilities as may be specified by supplemental agreement ....' is reproduced in this document for the information of all Members of the Agency

Design Fixation and Cooperative Learning in Elementary Engineering Design Project: A Case Study

Science.gov (United States)

Luo, Yi

2015-01-01

This paper presents a case study examining 3rd, 4th and 5th graders' design fixation and cooperative learning in an engineering design project. A mixed methods instrument, the Cooperative Learning Observation Protocol (CLOP), was adapted to record frequency and class observation on cooperative learning engagement through detailed field notes.…

49 CFR 268.21 - Down-selection of one or more Maglev projects for further study and selection of one project for...

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Down-selection of one or more Maglev projects for... Procedures For Financial Assistance § 268.21 Down-selection of one or more Maglev projects for further study... completion of Phase III of the Maglev Deployment Program, FRA will down-select one or more projects to...

French school of neurology in the 19 th and first half of the 20th century, and its influence in Brazil

Directory of Open Access Journals (Sweden)

Marleide da Mota Gomes

2013-10-01

Full Text Available French medicine was of the utmost importance for the birth of modern medicine and neurology in the 19 th century. Innovative approaches, such as examination at the bedside, the use of the stethoscope, techniques of auscultation, palpation, and close patient examination, besides emphasis on anatomical-clinical correlation and observation of the outcome of the disease, were put into practice. French medicine offered professional training and incentives for the beginnings of Brazilian neurology and psychiatry. Returning from France, many Brazilian physicians implemented what they had learned, mainly in Paris. The most important pupils of the French neurology schools in Brazil during the 19 th century and first half of the 20 th century include names like Antonio Austregesilo, Aloysio de Castro, Enjolras Vampré, and Deolindo Couto, founders of the leading Brazilian neurological schools, directly influenced by Dejerine, Pierre Marie, Guillain and Babinski.

Electronic Learning. Art: The 4th "R."

Science.gov (United States)

Ohler, Jason

2001-01-01

With the Internet revolution in education, students are learning to think as designers and artists. The language of art must become the fourth "R," and students must become literate in this environment. The paper discusses art and the digital age and what teachers can do (rename art, hire more art teachers, and increase fourth-R literacy…

The Effect of Learning Cycle Model on Students’ Reducing Ecological Footprints

Directory of Open Access Journals (Sweden)

Özgül Keleş

2011-12-01

Full Text Available The objective of this study is to investigate effect of ecological footprint education, in which 5E learning cycle model is used, in reducing primary school students’ ecological footprints. The working group of the study is composed of 124 primary school students studying in 4th, 5th, 6th, 7th, 8th classes. In this study, 5E learning model is used in teaching a course in order to increase the participating students’ knowledge about ecological footprints and to calculate ecological footprints. Experimental method is used in this study. In data analysis, the paired samples t-test is used in for relevant samplings. The findings gathered indicate that ecological footprints of the participating students to the study decreased at the end of the study. It is determined that the mean of primary students’ ecological footprints differ from meaningfully according to level of the class and sex. Prospective solution offers are developed by handling the prospective effects of conclusions of the study on sustainable life and environmental education and conclusions’ importance in terms of learning and developing learning programmes with a critical point of view

Let's Face(book) It: Analyzing Interactions in Social Network Groups for Chemistry Learning

Science.gov (United States)

Rap, Shelley; Blonder, Ron

2016-01-01

We examined how social network (SN) groups contribute to the learning of chemistry. The main goal was to determine whether chemistry learning could occur in the group discourse. The emphasis was on groups of students in the 11th and 12th grades who learn chemistry in preparation for their final external examination. A total of 1118 discourse…

Report on the 19th SPACE Conference

OpenAIRE

Rune Gulev

2008-01-01

The 19th international space (European Network for Business Studies and Languages) conference that recently took place in Spain provided valuable insight into several areas of interest. Most notably, methods on how to successfully enhance the internationalization of higher learning institutions were shared through mobility and joint degrees programs. Furthermore, the conference provided an academic forum for a highly professional and earnest discourse on pertinent topics of relevance for high...

Teachers’ Learning Design Practice for Students as Learning Designers

DEFF Research Database (Denmark)

Levinsen, Karin Tweddell; Sørensen, Birgitte Holm

2018-01-01

This paper contributes with elements of an emerging learning design methodology. The paper takes as its starting point the theory of Students as Learning Designers, which was developed by Sørensen and Levinsen and based on more than a decade of research-and-development projects in Danish primary...... schools (first to 10th grade). The research focussed on information and communication technology (ICT) within the Scandinavian tradition of Problem Oriented Project Pedagogy (POPP), Problem Based Learning (PBL) and students’ production. In recent years, the projects that provide the grounding...... for the theory have focussed specifically on learning designs that constitute students as learning designers of digital productions (both multimodal and coded productions). This includes learning designs that contribute to students’ empowerment, involvement and autonomy within the teacher-designed frameworks...

A survey on the effects of knowledge management on organizational learning: A case study of technical and vocational training organization

Directory of Open Access Journals (Sweden)

Naser Azad

2014-04-01

Full Text Available This paper presents an empirical investigation to study the effects of knowledge management on organizational learning. The study is held in headquarter of technical and vocational training organization in city of Tehran, Iran. The proposed study measures the effects of concept of management, management, knowledge tools, measurement, change management and knowledge content on organizational learning. The study designs a questionnaire in Likert scale and selects a sample of 313 people randomly from 1680 people who work for this organization in city of Tehran, Iran. Using structural equation modeling, the study has detected a positive and meaningful relationship with knowledge management on organizational learning. In our survey, knowledge content is the most important factor followed by change management.

Teachers’ Learning Design Practice for Students as Learning Designers

DEFF Research Database (Denmark)

Levinsen, Karin Tweddell; Sørensen, Birgitte Holm

2018-01-01

schools (first to 10th grade). The research focussed on information and communication technology (ICT) within the Scandinavian tradition of Problem Oriented Project Pedagogy (POPP), Problem Based Learning (PBL) and students’ production. In recent years, the projects that provide the grounding...

Concentration of thorium isotopes and the activity ratios of 230Th/232Th and 228Th/232Th in seawater in the Pacific Ocean

International Nuclear Information System (INIS)

Miyake, Yasuo; Sugimura, Yukio; Yasujima, Tadahide.

1978-01-01

The concentration of thorium isotopes and the activity ratios of 230 Th/ 232 Th and 228 Th/ 232 Th in 500 l sea water samples collected in the Pacific Ocean were determined. Thorium isotopes were analyzed by alpha-ray spectrometry after separating them from other elements with an anion exchange resin. The average content of thorium ( 232 Th) of 0.9 ng l -1 was obtained in the open Pacific water. The average contents of 230 Th and 228 Th were 2.1 x 10 -2 pgl -1 and 1.2 agl -1 respectively. It was found that the ratios of 230 Th/ 232 Th and 228 Th/ 232 Th ranged respectively from 1.0 to 29, and from 0.4 to as high as 128. (author)

Th1/Th2 cytokine expression in diabetic retinopathy.

Science.gov (United States)

Cao, Y L; Zhang, F Q; Hao, F Q

2016-07-15

Diabetic retinopathy (DR), an important complication of diabetes mellitus (DM), is not well understood. T helper cell balance (Th1/Th2) is involved in various autoimmune diseases; however, its role in DR is not understood. This study explores changes in Th1 and Th2 cytokine expression during DR. Blood samples were collected from 25 healthy volunteers (normal control group), 35 patients with type 2 DM (T2DM group) without DR, and 30 cases of T2DM patients with DR (DR group). Real-time PCR was used to measure mRNA expression of IL-2 and TNF-α, secreted from Th1 cells, and of IL-4 and IL-10, secreted from Th2 cells. We used ELISA to detect cytokine expression in serum to analyze the correlation between Th1 and Th2 cytokines. IL-2 and TNF-αmRNA and protein expression levels in the T2DM and DR groups were significantly higher than in the normal control group (P 0.05). IL-2 and TNF-αwere negatively correlated with IL-4 and IL-10 in the DR group, respectively. We found that Th1 cytokine secretion was higher and Th2 cytokines secretion was lower during DR, leading to a Th1/ Th2 imbalance, suggesting that Th1/Th2 imbalance is a side effect for DR occurrence and development.

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Cognition and Exploratory Learning in Digital Age (14th, Vilamoura, Algarve, Portugal, October 18-20, 2017)

Science.gov (United States)

Sampson, Demetrios G., Ed.; Spector, J. Michael, Ed.; Ifenthaler, Dirk, Ed.; Isaías, Pedro, Ed.

2017-01-01

These proceedings contain the papers of the 14th International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA 2017), 18-20 October 2017, which has been organized by the International Association for Development of the Information Society (IADIS) and endorsed by the Japanese Society for Information and Systems in…

11th International Conference on Computing and Information Technology

CERN Document Server

Meesad, Phayung; Boonkrong, Sirapat

2015-01-01

This book presents recent research work and results in the area of communication and information technologies. The book includes the main results of the 11th International Conference on Computing and Information Technology (IC2IT) held during July 2nd-3rd, 2015 in Bangkok, Thailand. The book is divided into the two main parts Data Mining and Machine Learning as well as Data Network and Communications. New algorithms and methods of data mining asr discussed as well as innovative applications and state-of-the-art technologies on data mining, machine learning and data networking.

Implementation and Evaluation of Web-Based Learning Activities on Bonding and the Structure of Matter for 10-th Grade Chemistry

Science.gov (United States)

Frailich, Marcel

This study deals with the development, implementation, and evaluation of web-based activities associated with the topic of chemical bonding , as taught in 10th grade chemistry. A website was developed entitled: "Chemistry and the Chemical Industry in the Service of Mankind", its URL is: http://stwww.weizmann.ac.il/g-chem/learnchem (Kesner, Frailich, & Hofstein, 2003). The main goal of this study was to assess the educational effectiveness of website activities dealing with the chemical bonding concept. These activities include visualization tools, as well as topics relevant to daily life and industrial applications. The study investigated the effectiveness of a web-based learning environment regarding the understanding of chemical bonding concepts, students' perceptions of the classroom learning environment, their attitudes regarding the relevance of learning chemistry to everyday life, and their interest in chemistry studies. As mentioned before, in the present study we focused on activities (from the website), all of which deal with chemical bonding concept. The following are the reasons for the decision to focus on this topic: (1) Chemical bonding is a key concept that is taught in 10th grade chemistry in high school. It provides the basis for many other chemistry topics that are taught later, and (2) Chemical bonding is a difficult for students using existing tools (e. g., static models in books, ball-and- stick models), which are insufficient to demonstrate the abstract nature phenomena associated with this topic. The four activities developed for this study are (1) models of the atomic structure, (2) metals -- structure and properties, (3) ionic substances in everyday life and in industry, and (4) molecular substances -- structure, properties, and uses. The study analyzed both quantitative and qualitative research. The quantitative tools of the study included: A Semantic Differential questionnaire and a Chemistry Classroom Web-Based Learning Environment

Reorganizing Geographic Combatant Command Headquarters for Joint Force 2020

Science.gov (United States)

2013-05-01

Keegan, Global Marketing Management, 7 th Ed. (Upper Saddle River, NJ: Prentice Hall, 2002), 523. 30 Hellriegel, Jackson, and Slocum, Management...bring together mission, resources, and time. 31 Keegan, Global Marketing Management, 520. 20... Marketing Management, 523. 34 Keegan, Global Marketing Management, 523. 22 strategic alliance is an “agreement for cooperation among two or more

Command History. 1968. Volume 1. Sanitized.

Science.gov (United States)

1968-01-01

battalions. Additionally, a diary captured on 19 December, Z1 kilometers southwest of Song Cau, revealed that on 19 November the author. a cadre member...the 306th and 312th ( AYA 308th) Bns. This reorga- nization was an apparent attempt by the headquarters of MR 3 to tighten its command and con- trol. (C

Work-Based Learning: Good News, Bad News and Hope. Research Brief.

Science.gov (United States)

Bottoms, Gene; Presson, Alice

The effects of work-based learning on student achievement were examined by analyzing data from the 1996 High Schools That Work (HSTW) assessment. The comparison focused on the experiences of 12th-graders in structured work-based learning programs and 12th-graders with after-school jobs. A larger percentage of students earning school credit for…

Genetic variants of ACE (Insertion/Deletion) and AGT (M268T) genes in patients with diabetes and nephropathy.

Science.gov (United States)

Shaikh, Rozeena; Shahid, Syed M; Mansoor, Qaisar; Ismail, Muhammad; Azhar, Abid

2014-06-01

Diabetes mellitus (DM) has been a growing epidemic worldwide and poses a major socio-economic challenge. The leading cause of DM death is nephropathy due to end-stage renal disease (ESRD). This study aims to identify the possible association of I/D variants of the ACE gene and M268T (rs699) of the AGT gene of renin-angiotensin-aldosterone system (RAAS). Study subjects include 115 patients with DM, 110 with diabetic nephropathy (DN) and 110 controls. Fasting blood samples were collected for biochemical analyses and PCR amplification of specific regions of the ACE and AGT genes using primers. The distribution of ACE (I/D) II 28.8%, ID 35.6% and DD 35.6% while in DN II 24.5%, ID 41% and DD 34.5%. The AGT (M268T) genotypes were distributed in DM as TT 30.4%, MT 66.9% and MM 2.6% while in DN subjects TT 56.4%, MT 42.7% and MM 0.9%. Significant differences were observed in the DD genotype and D allele of the ACE gene and the TT genotype and T allele of AGT genes between diabetic patients with and without nephropathy. The study may conclude that the D allele polymorphism in the ACE gene and the T allele polymorphism in AGT gene may be considered as genetic risk factors for the development of nephropathy in diabetes. © The Author(s) 2014.

Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells.

Science.gov (United States)

Basdeo, Sharee A; Cluxton, Deborah; Sulaimani, Jamal; Moran, Barry; Canavan, Mary; Orr, Carl; Veale, Douglas J; Fearon, Ursula; Fletcher, Jean M

2017-03-15

Th17 cells are an important therapeutic target in autoimmunity. However, it is known that Th17 cells exhibit considerable plasticity, particularly at sites of autoimmune inflammation. Th17 cells can switch to become ex-Th17 cells that no longer produce IL-17 but produce IFN-γ. These ex-Th17 cells are also called nonclassical Th1 cells because of their ability to produce IFN-γ, similar to Th1 cells; however, it is unclear whether they resemble Th1 or Th17 cells in terms of their function and regulation, and whether they have a pathogenic role in autoimmunity. We compared the phenotypic and functional features of human Th17, Th1, and ex-Th17 cell populations. Our data showed that despite their loss of IL-17 expression, ex-Th17 cells were more polyfunctional in terms of cytokine production than either Th1 or bona fide Th17 cells, and produced increased amounts of proinflammatory cytokines. The proliferative brake on Th17 cells appeared to be lifted because ex-Th17 cells proliferated more than Th17 cells after stimulation. In contrast with Th1 and Th17 cells, ex-Th17 cells were highly resistant to suppression of proliferation and cytokines by regulatory T cells. Finally, we showed that ex-Th17 cells accumulated in the joints of rheumatoid arthritis patients. Taken together, these data indicate that human ex-Th17 cells are functionally distinct from Th1 and Th17 cells, and suggest that they may play a pathogenic role at sites of autoimmunity, such as the rheumatoid arthritis joint where they accumulate. These findings have implications for therapeutic strategies that target IL-17, because these may not inhibit pathogenic ex-Th17 cells. Copyright © 2017 by The American Association of Immunologists, Inc.

Suicidal ideation among students of the 7th, 8th, and 9th grades in the State of Lara, Venezuela: the Global School Health Survey.

Science.gov (United States)

Granero, Ricardo; Poni, Esteban; Poni, Carolin

2008-12-01

Suicidal behavior among adolescents is not a well-explored public health problem. Health policy decision-making on suicidal behavior needs reliable information on the prevalence of suicidal ideation (SI) and its associated risk factors to produce health promotion and prevention programs. The Global School Health Survey is a self-administered survey done on a random probabilistic sample among students of the 7th, 8th, and 9th grades in the Lara State, Venezuela, school period 2003 to 2004. Point prevalence of SI and associated factors were included and the odds (OR) of having SI was calculated given selected factors. Two-thousand seventy (2070) respondents, of which 13.5 % reported having SI in the last 12 months, and in females more than males (14.6% vs. 11.7%). The OR for SI, according to an associated risk factor, were among (a) females: age > or = 14 years (2.2), worries (3.42), loneliness (8.8), ever had sexual intercourse (5.58), alcohol (8.43) and (b) males: having only one or non close friends (3.69), alcohol (12.36), ever had sexual intercourse (2.73). Behavioral risk factors are relatively new in the field of surveillance systems; therefore, results on SI should be cautiously taken into consideration and a wide discussion should be encouraged as we learn how to best use the results for health promotion and disease prevention.

Teachers’ Learning Design Practice for Students as Learning Designers

DEFF Research Database (Denmark)

Levinsen, Karin Tweddell; Sørensen, Birgitte Holm

2018-01-01

that simultaneously scaffold students’ subject-related inquiry, agency, reflection and learning. Research studies have documented that this approach constitutes arenas that support students’ deep learning and mastery of both transdisciplinary and subject matter, along with their acquisition of digital literacy and 21......This paper contributes with elements of an emerging learning design methodology. The paper takes as its starting point the theory of Students as Learning Designers, which was developed by Sørensen and Levinsen and based on more than a decade of research-and-development projects in Danish primary...... schools (first to 10th grade). The research focussed on information and communication technology (ICT) within the Scandinavian tradition of Problem Oriented Project Pedagogy (POPP), Problem Based Learning (PBL) and students’ production. In recent years, the projects that provide the grounding...

Contextual Approach with Guided Discovery Learning and Brain Based Learning in Geometry Learning

Science.gov (United States)

Kartikaningtyas, V.; Kusmayadi, T. A.; Riyadi

2017-09-01

The aim of this study was to combine the contextual approach with Guided Discovery Learning (GDL) and Brain Based Learning (BBL) in geometry learning of junior high school. Furthermore, this study analysed the effect of contextual approach with GDL and BBL in geometry learning. GDL-contextual and BBL-contextual was built from the steps of GDL and BBL that combined with the principles of contextual approach. To validate the models, it uses quasi experiment which used two experiment groups. The sample had been chosen by stratified cluster random sampling. The sample was 150 students of grade 8th in junior high school. The data were collected through the student’s mathematics achievement test that given after the treatment of each group. The data analysed by using one way ANOVA with different cell. The result shows that GDL-contextual has not different effect than BBL-contextual on mathematics achievement in geometry learning. It means both the two models could be used in mathematics learning as the innovative way in geometry learning.

Specific de-SUMOylation triggered by acquisition of spatial learning is related to epigenetic changes in the rat hippocampus.

Science.gov (United States)

Castro-Gomez, Sergio; Barrera-Ocampo, Alvaro; Machado-Rodriguez, Gloria; Castro-Alvarez, John F; Glatzel, Markus; Giraldo, Marco; Sepulveda-Falla, Diego

2013-12-04

Histone acetyltransferase activity by transcriptional cofactors such as CREB-binding protein (CBP) and post-translational modifications by small ubiquitin-like modifier-1 (SUMO-1) have shown to be relevant for synaptic and neuronal activity. Here, we investigate whether SUMOylation of CBP plays a role in spatial learning. We assessed protein levels of CBP/p300, SUMO-1, and CBP SUMOylation in the hippocampi of rats trained on the Morris water maze task. Furthermore, we evaluated the post-translational modifications at Zif268, BDNF, and Arc/Arg3.1 promoters using chromatin immunoprecipitation with anti-Acetyl-Histone H3-Lys14 (H3K14Ac) and SUMO-1. We found that CBP/p300 protein expression is unchanged in animals trained for 7 days. However, H3K14Ac-specific histone acetyltransferase activity showed specific hyperacetylation at promoters of Zif268 and BDNF-pI but not of Arc/Arg3.1 and BDNF-pIV. In naive animals, CBP is selectively SUMOylated and the Arc/Arg3.1 promoter is differentially occupied by SUMO-1, although SUMO-1 levels are unchanged. These results suggest a specific negative regulation by SUMO-1 on CBP function and its effect on epigenetic changes triggered by spatial learning and memory processes.

From Cloister to Commons: Concepts and Models for Service-Learning in Religious Studies. AAHE's Series on Service-Learning in the Disciplines.

Science.gov (United States)

Devine, Richard, Ed.; Favazza, Joseph A., Ed.; McLain, F. Michael, Ed.

This essays in this volume, 19th in a series, discuss why and how service-learning can be implemented in Religious Studies and what that discipline contributes to the pedagogy of service-learning. Part 1, "Service-Learning and the Dilemma of Religious Studies," contains: (1) "Service-Learning and the Dilemma of Religious Studies: Descriptive or…

8th International Conference KES-AMSTA

CERN Document Server

Kusek, Mario; Lovrek, Ignac; Howlett, Robert; Jain, Lakhmi

2014-01-01

Agents and multi-agent systems are related to a modern software paradigm which has long been recognized as a promising technology for constructing autonomous, complex and intelligent systems. The topics covered in this volume include agent-oriented software engineering, agent co-operation, co-ordination, negotiation, organization and communication, distributed problem solving, multi-agent communities, rational and clustering agents, learning paradigms, agent cognitive models, and heterogenous multi-agent environments.   The volume highlights new trends and challenges in agent and multi-agent research and includes 30 papers classified in five specific topics: Modeling and logic agents, Knowledge based agent systems, Cognitive and cooperative multi-agent systems, Agent-based Modeling and Simulation, and Learning Paradigms and Applications: Agent-based Approach. The published papers have been presented at the 8th KES Conference on Agent and Multi-Agent Systems – Technologies and Applications (KES-AMSTA 2014) ...

Open Learning for Smart Education: Open educational policies, strategies & access for all

NARCIS (Netherlands)

Stracke, Christian M.

2016-01-01

keynote on Open Learning at the International IEEE EDUCON Conference 2016: I will speak about “Open Learning for Smart Education: Open educational policies, strategies and access for all”. This year EDUCON is taking place from 10th to 13th of April 2016 in Abu Dhabi. My questions of the keynote

HI absorption in 3C 49 and 3C 268.3 - Probing the environment of compact steep spectrum and GHz peaked spectrum sources

NARCIS (Netherlands)

Labiano, A; Vermeulen, RC; Barthel, PD; O'Dea, CP; Gallimore, JF; Baum, S; de Vries, W

Aims. Localize and study the redshifted 21 cm H I absorption known to occur in the subgalactic sized compact steep spectrum galaxies 3C 49 and 3C 268.3. Methods. We carried out European VLBI Network UHF hand spectral line observations. Results. We have detected H I absorption towards the western

Promoting Cooperative Learning in the Classroom: Comparing Explicit and Implicit Training Techniques

Directory of Open Access Journals (Sweden)

Anne Elliott

2003-07-01

Full Text Available In this study, we investigated whether providing 4th and 5th-grade students with explicit instruction in prerequisite cooperative-learning skills and techniques would enhance their academic performance and promote in them positive attitudes towards cooperative learning. Overall, students who received explicit training outperformed their peers on both the unit project and test and presented more favourable attitudes towards cooperative learning. The findings of this study support the use of explicitly instructing students about the components of cooperative learning prior to engaging in collaborative activities. Implications for teacher-education are discussed.

Building a quality culture in the Office of Space Flight: Approach, lessons learned and implications for the future

Science.gov (United States)

Roberts, C. Shannon

1992-01-01

The purpose of this paper is to describe the approach and lessons learned by the Office of Space Flight (OSF), National Aeronautics and Space Administration (NASA), in its introduction of quality. In particular, the experience of OSF Headquarters is discussed as an example of an organization within NASA that is considering both the business and human elements of the change and the opportunities the quality focus presents to improve continuously. It is hoped that the insights shared will be of use to those embarking upon similar cultural changes. The paper is presented in the following parts: the leadership challenge; background; context of the approach to quality; initial steps; current initiatives; lessons learned; and implications for the future.

Concentration of 232Th, 230Th and 228Th in various tissues of Japanese subjects

International Nuclear Information System (INIS)

Takizawa, Y.; Qingmei, H.; Hisamatsu, S.; Abe, T.

1997-01-01

The concentration of 232 Th, 230 Th and 228 Th in various human tissues of Japanese subjects obtained at autopsies are reported. The tissue samples were weighed, spiked with 234 Th tracer and ashed by acid. The solution was dried on a hot-plate. Separation of thorium radionuclides was accomplished through cation-exchange resin chromatography and electrodeposition. The concentrations of thorium isotopes were measured by α-spectrometry. Thorium-232 and 230 Th concentrations were found to be highest in lung, followed by bone. The maximum concentration of 228 Th was in bone. The lowest concentrations of thorium isotopes were in muscle. (author)

Identification of DRG-1 As a Melanoma-Associated Antigen Recognized by CD4+ Th1 Cells.

Directory of Open Access Journals (Sweden)

Yukiko Kiniwa

Full Text Available Immunotherapy has emerged as a promising strategy for the treatment of metastatic melanoma. Clinical studies have demonstrated the feasibility of cancer immunotherapy using tumor antigens recognized by CD8(+ T cells. However, the overall immune responses induced by these antigens are too weak and transient to induce tumor regression in the majority of patients who received immunization. A growing body of evidence suggests that CD4(+ T helper (Th cells play an important role in antitumor immunity. Therefore, the identification of MHC class II-restricted tumor antigens capable of stimulating CD4(+ T cells may provide opportunities for developing effective cancer vaccines. To this end, we describe the identification of developmentally regulated GTP-binding protein 1 (DRG-1 as a melanoma-associated antigen recognized by HLA-DR11-restricted CD4(+ Th1 cells. Epitope mapping analysis showed that the DRG1248-268 epitope of DRG-1 was required for T cell recognition. Reverse transcription-polymerase chain reaction revealed that DRG-1 was highly expressed in melanoma cell lines but not in normal tissues. DRG-1 knockdown by lentiviral-based shRNA suppressed melanoma cell proliferation and soft agar colony formation. Taken together, these data suggest that DRG-1 plays an important role in melanoma cell growth and transformation, indicating that DRG1 may represent a novel target for CD4(+ T cell-mediated immunotherapy in melanoma.

Identification of DRG-1 As a Melanoma-Associated Antigen Recognized by CD4+ Th1 Cells.

Science.gov (United States)

Kiniwa, Yukiko; Li, Jiang; Wang, Mingjun; Sun, Chuang; Lee, Jeffrey E; Wang, Rong-Fu; Wang, Helen Y

2015-01-01

Immunotherapy has emerged as a promising strategy for the treatment of metastatic melanoma. Clinical studies have demonstrated the feasibility of cancer immunotherapy using tumor antigens recognized by CD8(+) T cells. However, the overall immune responses induced by these antigens are too weak and transient to induce tumor regression in the majority of patients who received immunization. A growing body of evidence suggests that CD4(+) T helper (Th) cells play an important role in antitumor immunity. Therefore, the identification of MHC class II-restricted tumor antigens capable of stimulating CD4(+) T cells may provide opportunities for developing effective cancer vaccines. To this end, we describe the identification of developmentally regulated GTP-binding protein 1 (DRG-1) as a melanoma-associated antigen recognized by HLA-DR11-restricted CD4(+) Th1 cells. Epitope mapping analysis showed that the DRG1248-268 epitope of DRG-1 was required for T cell recognition. Reverse transcription-polymerase chain reaction revealed that DRG-1 was highly expressed in melanoma cell lines but not in normal tissues. DRG-1 knockdown by lentiviral-based shRNA suppressed melanoma cell proliferation and soft agar colony formation. Taken together, these data suggest that DRG-1 plays an important role in melanoma cell growth and transformation, indicating that DRG1 may represent a novel target for CD4(+) T cell-mediated immunotherapy in melanoma.

Teaching systems thinking to 4th and 5th graders using Environmental Dashboard display technology.

Science.gov (United States)

Clark, Shane; Petersen, John E; Frantz, Cindy M; Roose, Deborah; Ginn, Joel; Rosenberg Daneri, Daniel

2017-01-01

Tackling complex environmental challenges requires the capacity to understand how relationships and interactions between parts result in dynamic behavior of whole systems. There has been convincing research that these "systems thinking" skills can be learned. However, there is little research on methods for teaching these skills to children or assessing their impact. The Environmental Dashboard is a technology that uses "sociotechnical" feedback-information feedback designed to affect thought and behavior. Environmental Dashboard (ED) combines real-time information on community resource use with images and words that reflect pro-environmental actions of community members. Prior research indicates that ED supports the development of systems thinking in adults. To assess its impact on children, the technology was installed in a primary school and children were passively exposed to ED displays. This resulted in no measurable impact on systems thinking skills. The next stage of this research examined the impact of actively integrating ED into lessons on electricity in 4th and 5th grade. This active integration enhanced both content-related systems thinking skills and content retention.

The development of learning material using learning cycle 5E model based stem to improve students’ learning outcomes in Thermochemistry

Science.gov (United States)

sugiarti, A. C.; suyatno, S.; Sanjaya, I. G. M.

2018-04-01

The objective of this study is describing the feasibility of Learning Cycle 5E STEM (Science, Technology, Engineering, and Mathematics) based learning material which is appropriate to improve students’ learning achievement in Thermochemistry. The study design used 4-D models and one group pretest-posttest design to obtain the information about the improvement of sudents’ learning outcomes. The subject was learning cycle 5E based STEM learning materials which the data were collected from 30 students of Science class at 11th Grade. The techniques used in this study were validation, observation, test, and questionnaire. Some result attain: (1) all the learning materials contents were valid, (2) the practicality and the effectiveness of all the learning materials contents were classified as good. The conclution of this study based on those three condition, the Learnig Cycle 5E based STEM learning materials is appropriate to improve students’ learning outcomes in studying Thermochemistry.

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA) (13th, Mannheim, Germany, October 28-30, 2016)

Science.gov (United States)

Sampson, Demetrios G., Ed.; Spector, J. Michael, Ed.; Ifenthaler, Dirk, Ed.; Isaias, Pedro, Ed.

2016-01-01

These proceedings contain the papers of the 13th International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA 2016), October 28-30, 2016, which has been organized by the International Association for Development of the Information Society (IADIS), co-organized by the University of Mannheim, Germany, and endorsed by the…

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA) (11th, Porto, Portugal, October 25-27, 2014)

Science.gov (United States)

Sampson, Demetrios G., Ed.; Spector, J. Michael, Ed.; Ifenthaler, Dirk, Ed.; Isaias, Pedro, Ed.

2014-01-01

These proceedings contain the papers of the 11th International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA 2014), October 25-27, 2014, which has been organized by the International Association for Development of the Information Society (IADIS) and endorsed by the Japanese Society for Information and Systems in…

LearnSafe. Learning organisations for nuclear safety

International Nuclear Information System (INIS)

Wahlstroem, B.; Kettunen, J.; Reiman, T.

2005-03-01

The nuclear power industry is currently undergoing a period of major change, which has brought with it a number of challenges. These changes have forced the nuclear power plants to initiate their own processes of change in order to adapt to the new situation. This adaptation must not compromise safety at any time, but during a rapid process of change there is a danger that minor problems may trigger a chain of events leading to a degraded safety. Organisational learning has been identified as an important component in ensuring the continued safety and efficiency of nuclear organisations. In response to these challenges a project LearnSafe 'Learning organisations for nuclear safety' was set up and funded by the European Community under the 5th Euratom Framework Programme. The present report gives an account of the LearnSafe project and its major results. (orig.)

Screening for Hypothyroidism-Results of a Study Conducted at District Headquarter Hospital, Abbottabad

International Nuclear Information System (INIS)

Gul, N.; Farid, J.; Idris, M.; Sarwar, J.

2016-01-01

Background: Sub-clinically hypo-functioning thyroid is a condition in which there is biochemical evidence of hypothyroidism but patient is clinically asymptomatic. This concept is not new. The typical picture of this condition is increased thyroid stimulating hormone and normal thyroxine levels. Subclinical hypothyroidism has been found to have variable prevalence ranging from 4-10 percent to 10-26 percent. Methods: This cross sectional study was conducted on 378 adult patients coming to outpatient department of District Headquarter Hospital Abbottabad over a period of two years from February 2013 to February 2015. Results: Out of the 378 individuals studied, 37 (9.78 percent) had subclinical hypothyroidism. Mean age of the patients was 43.5±10.5 years. Females outnumbered males, i.e., 24 out of 37 (65 percent). It was noted that there was no correlation between mean TSH level and gender or age of the patients. Conclusion: Subclinical hypothyroidism is not an uncommon condition and its diagnosis is established easily by doing thyroid hormone levels in fasting condition. Early diagnosis and therapeutic intervention may not only prevent the progression to clinical hypothyroidism but also help in preventing the wastage of resources on doing unnecessary investigations. (author)

Screening For Hypothyroidism-Results Of A Study Conducted At District Headquarter Hospital, Abbottabad.

Science.gov (United States)

Gul, Nasreen; Farid, Jamila; Idris, Muhammad; Sarwar, Javed

2016-01-01

Sub-clinically hypo-functioning thyroid is a condition in which there is biochemical evidence of hypothyroidism but patient is clinically asymptomatic. This concept is not new. The typical picture of this condition is increased thyroid stimulating hormone and normal thyroxine levels. Subclinical hypothyroidism has been found to have variable prevalence ranging from 4-10% to 10- 26%. This cross sectional study was conducted on 378 adult patients coming to outpatient department of District Headquarter Hospital Abbottabad over a period of two years from February 2013 to February 2015. Out of the 378 individuals studied, 37 (9.78%) had subclinical hypothyroidism. Mean age of the patients was 43.5±10.5 years. Females outnumbered males, i.e., 24 out of 37 (65%). It was noted that there was no correlation between mean TSH level and gender or age of the patients. Subclinical hypothyroidism is not an uncommon condition and its diagnosis is established easily by doing thyroid hormone levels in fasting condition. Early diagnosis and therapeutic intervention may not only prevent the progression to clinical hypothyroidism but also help in preventing the wastage of resources on doing unnecessary investigations.

Proceedings of the Seventh International Conference on Educational Data Mining (EDM) (7th, London, United Kingdom, July 4-7, 2014)

Science.gov (United States)

Stamper, John, Ed.; Pardos, Zachary, Ed.; Mavrikis, Manolis, Ed.; McLaren, Bruce M., Ed.

2014-01-01

The 7th International Conference on Education Data Mining held on July 4th-7th, 2014, at the Institute of Education, London, UK is the leading international forum for high-quality research that mines large data sets in order to answer educational research questions that shed light on the learning process. These data sets may come from the traces…

EVALUATION OF THE LEARNING SYSTEM BASED ON RESEARCH (SABI IN THE CICS UMA IPN BIOCHEMISTRY UNIT

Directory of Open Access Journals (Sweden)

Blanca Elisa Pérez-Magaña

2014-07-01

Full Text Available Learning is a steward, permanent, and participatory process where: the apprentice, teacher, classmates, institution and other social factors where the student performs. As detonator of learning is research, which is made from real events that are addressed on the basis of the scientific development of the State of the art. One of the key elements in the professional training of students is the method that is used. Research-based learning system is an educational innovation (SABI, which was used in the learning of basic sciences of the Cardiovascular apparatus in generations unit 33rd, 34th, 35th, 36th and 37th generations in the years of 2008 to 2012's career in medicine and as a result was a decrease in the number of students reproachedimproving achievement. This method is an excellent alternative in the teaching-learning process and can be used both in groups with a variable number of students.

Proceedings of the 2nd Workshop on Awareness and Reflection in Technology-Enhanced Learning

NARCIS (Netherlands)

Moore, Adam; Pammer, Viktoria; Pannese, Lucia; Prilla, Michael; Rajagopal, Kamakshi; Reinhardt, Wolfgang; Ullman, Thomas; Voigt, Christian

2013-01-01

Moore, A., Pammer, V., Pannese, L., Prilla, M., Rajagopal, K., Reinhardt, W., Ullman, Th. D., & Voigt, Ch. (Eds.) (2012). Proceedings of the 2nd Workshop on Awareness and Reflection in Technology Enhanced Learning. In conjunction with the 7th European Conference on Technology Enhanced Learning: 21st

Lifelong learning in aviation and medicine; Comments and suggestions

NARCIS (Netherlands)

Boshuizen, Els

2011-01-01

Boshuizen, H. P. A. (2010, 25-27 August). Lifelong learning in aviation and medicine; Comments and suggestions. Discussion at the 5th EARLI-SIG14 Learning and Professional Development, Munich, Germany.

Use of Learning Media by Undergraduate Medical Students in Pharmacology: A Prospective Cohort Study

Science.gov (United States)

Gutmann, Joanna; Kühbeck, Felizian; Berberat, Pascal O.; Fischer, Martin R.; Engelhardt, Stefan; Sarikas, Antonio

2015-01-01

The ubiquity of the internet and computer-based technologies has an increasing impact on higher education and the way students access information for learning. Moreover, there is a paucity of information about the quantitative and qualitative use of learning media by the current student generation. In this study we systematically analyzed the use of digital and non-digital learning resources by undergraduate medical students. Daily online surveys and semi-structured interviews were conducted with a cohort of 338 third year medical students enrolled in a general pharmacology course. Our data demonstrate a predominant use of digital over non-digital learning resources (69 ± 7% vs. 31 ± 7%; p students. Most used media for learning were lecture slides (26.8 ± 3.0%), apps (22.0 ± 3.7%) and personal notes (15.5 ± 2.7%), followed by textbooks (> 300 pages) (10.6 ± 3.3%), internet search (7.9 ± 1.6%) and e-learning cases (7.6 ± 3.0%). When comparing learning media use of teaching vs. pre-exam self-study periods, textbooks were used significantly less during self-study (-55%; p learning cases (+176%; p learning resources by undergraduate medical students, in particular mobile applications. PMID:25849565

The Effectiveness of Cooperative Learning Methods on 7th Level “The Structure of Matter and Properties” Unit

Directory of Open Access Journals (Sweden)

Yasemin KOÇ

2016-04-01

Full Text Available The aim of this research are to determine the effectiveness of Student Teams-Achievement Division (STAD and Reading-Writing-Application (RWA methods of cooperative learning model on academic achievement at the unit of 7th Level “The Structure of Matter and Properties” and students’ views related to methods. The sample of this research are 102 students from two different secondary school in Ağrı. As data collecting tools, Pre-Knowledge Test (PKT, Academic Achievement Test (AAT and Scale Methods Views (SMV is used. For the analysis of the obtained data, one-way variance analysis (ANOVA was used for pre- test and analysis covariance (ANCOVA for academic achievement test because of significant differences in the groups’ pre- test. Descriptive statistics for students’ views about methods are used. It was found that RWA and STAD have similar effects on students’ academic achievement and students instructed with these techniques are more successful than students instructed with teacher centered instruction.

Creating by Reusing Learning Design Solutions

NARCIS (Netherlands)

Hernández-Leo, Davinia; Harrer, Andreas; Dodero, Juan Manuel; Asensio-Pérez, Juan; Burgos, Daniel

2006-01-01

Hernández-Leo, D., Harrer, A., Dodero, J. M., Asension-Pérez, J. I., & Burgos, D. (2006). Creating by reusing Learning Design solutions. Proceedings of 8th Simposo Internacional de Informática Educativa, León, Spain: IEEE Technical Committee on Learning Technology. Retrieved October 3rd, 2006, from

Knowledge Sharing Practice in a Play-Like Learning Environment

DEFF Research Database (Denmark)

Benjaminsen, Nana

2007-01-01

The topic of this paper is play-like learning as it occurs when technology based learning environments is invited into the classroom. Observations of 5th grade classes playing with Lego Robolab, is used to illustrate that different ways of learning becomes visible when digital technology...

Assessing Creative Thinking in Design-Based Learning

Science.gov (United States)

Doppelt, Yaron

2009-01-01

Infusing creative thinking competence through the design process of authentic projects requires not only changing the teaching methods and learning environment, but also adopting new assessment methods, such as portfolio assessment. The participants in this study were 128 high school pupils who have studied MECHATRONICS from 10th to 12th grades…

La conception des environnements d’apprentissage : de la théorie à la pratique / de la pratique à la théorie La conception des environnements d’apprentissage : de la théorie à la pratique / de la pratique à la théorie

Directory of Open Access Journals (Sweden)

Jean-Jacques Quintin

2000-06-01

Full Text Available Cet article présente une approche en matière de conception d’environnements d’apprentissage multimédia qualifiée d’incrémentielle et d’itérative en ce sens qu’elle repose sur un affinage progressif du produit dans le cadre d’un partenariat étroit entre concepteur et client. L’approche proposée implique notamment la mise au point de prototypes qui feront l’objet de validations systématiques afin d’assurer l’adéquation avec les exigences et les contraintes du milieu d’accueil. S’appuyant sur une double posture de chercheur et de concepteur, l’approche se nourrit de la théorie en s’appuyant sur des modèles mais elle nourrit également la théorie à travers l’effort de modélisation qui l’accompagne.This paper describes a method of developing multimedia learning environments based on a close collaboration between the client and the team of developers. This approach uses different tools ans techniques (prototype, storyboard, concept maps... to progressively elaborate a product adequate to the client requirements and to ensure sufficient quality. Taking advantage of our specific situation of researchers and designers, the method is based on a coming and going between the pedagogical model and the development of a practical learning environment.

Supplemental Environmental Assessment for the Mid-Bay Bridge Connector Phases 2 and 3, Eglin Air Force Base, Florida

Science.gov (United States)

2010-08-03

D. Rodriigue;c 96 CEGICEVS PEPARTMENT OF THE AWR FORCE HEADQUARTERS 96TH AIR &ASE WING (AFMC) EGUN AJR FORCE BASE, FLORIDA 501 Deleon Stteet...Supplemental Environmental Assessment Maria D. Rodriguez 96CEG/CEVS DEPARTMENT OF THE AiR FORCE HEADQUARTERS 96Tit AIR BASE WING (I’ fMC) EGUN AIR FORCE...BASE WING (AFMC) EGUN AIR fORCE BASE, FLORIDA Historic Preservation Specialist Old Post Office Building 1100 Pennsylvania Avenue, NW, Suite 803

IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.

Science.gov (United States)

Mitchell, Ruth E; Hassan, Masriana; Burton, Bronwen R; Britton, Graham; Hill, Elaine V; Verhagen, Johan; Wraith, David C

2017-09-12

IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4 + T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 production by a chronically stimulated antigen-specific population of differentiated Th1 cells. In vitro, IL-4 blockade inhibited while addition of exogenous IL-4 to Th1 cultures enhanced IL-10 production. In the in vivo setting of peptide immunotherapy leading to a chronically stimulated Th1 phenotype, lack of IL-4Rα inhibited the induction of IL-10. Exploring the interplay of Th1 and Th2 cells through co-culture, Th2-derived IL-4 promoted IL-10 expression by Th1 cultures, reducing their pathogenicity in vivo. Co-culture led to upregulated c-Maf expression with no decrease in the proportion of T-bet + cells in these cultures. Addition of IL-4 also reduced the encephalitogenic capacity of Th1 cultures. These data demonstrate that IL-4 contributes to IL-10 production and that Th2 cells modulate Th1 cultures towards a self-regulatory phenotype, contributing to the cross-regulation of Th1 and Th2 cells. These findings are important in the context of Th1 driven diseases since they reveal how the Th1 phenotype and function can be modulated by IL-4.

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA) (12th, Maynooth, Greater Dublin, Ireland, October 24-26, 2015)

Science.gov (United States)

Sampson, Demetrios G., Ed.; Spector, J. Michael, Ed.; Ifenthaler, Dirk, Ed.; Isaias, Pedro, Ed.

2015-01-01

These proceedings contain the papers of the 12th International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA 2015), October 24-26, 2015, which has been organized by the International Association for Development of the Information Society (IADIS), co-organized by Maynooth University, Ireland, and endorsed by the…

78 FR 69929 - Fifty-Ninth Meeting: RTCA Special Committee 186, Automatic Dependent Surveillance-Broadcast (ADS-B)

Science.gov (United States)

2013-11-21

... meeting will be held at the RTCA Headquarters, 1150 18th Street NW., Suite 910, Washington, DC 20036. FOR FURTHER INFORMATION CONTACT: The RTCA Secretariat, 1150 18th Street NW., Suite 910, Washington, DC 20036... Interoperability Requirements Document for Traffic Situation Awareness with Alerts (TSAA), RTCA Paper No. 242-13...

Determination of 232Th, 230Th and 228Th in liquid effluents from uranium mining

International Nuclear Information System (INIS)

Godoy, Jose Marcus de Oliveira

1979-10-01

A liquid scintillator αlpha spectrometer was built for the determination of Th- 228 , Th- 230 and Th- 232 in liquid effluents from Uranium mines and mills. The resolution of the αlpha spectrometer was found to be 200-300 KeV, when the scintillator was 8% T0P0, 0,77% scintimix-4 (91% PP0 and 9% Dimetil-P0P0P) and 10% of naphthalene in toluene. Aliquat-336 in xylene (30% v/v) was used to separate the thorium isotopes from other interfering radionuclides (U- 238 , U- 234 , Ra- 226 , Po- 210 ). Under the extraction experimental conditions, the detection limits were 1,2 pCi/1 for Th- 232 , 1,2 pCi/1 for Th- 230 and 0,9 pCi/1 for Th- 228 , for 1000 minutes of counting time. (author)

Comparison of Values in 5th, 6th, 7th and 8th Grade Primary Education Music Class Students'? Workbooks According to Rokeach?s and Akbas's Value Classifications

Science.gov (United States)

Çakirer, H. Serdar

2014-01-01

The aim of the present study is to compare the values in the songs of 5th, 6th, 7th and 8th grade primary education music classes students? workbooks according to the value categorizations proposed by Rockeach and Akbas and which values among the categories mentioned are taught to the students in the 5th, 6th, 7th and 8th grade primary education…

Cyberl@b: a platform for learning english in Costa Rican public high schools

OpenAIRE

Allen Quesada Pacheco

2006-01-01

Abstract: This paper covers the design and development of a noncommercial software for learning and practicing English called CyberL@b. It was developed at the School of Modern Languages at the University of Costa Rica. Its target population focuses on 7th, 8th and 9th graders at six public high schools in diverse urban and rural settings in Costa Rica.CyberL@b uses interactive media resources designed to engage student in learning English within authentic contexts.Cyberlab was designed to cr...

The Trajectory of Scholarship about Self-Regulated Learning

Science.gov (United States)

Winne, Philip H.

2017-01-01

The trajectory of scholarship about self-regulated learning (SRL) originates in mid-19th-century writings about learners' sense of responsibility in self education. Although Descartes's 17th-century writings implied mental activities consistent with metacognition, a central feature of SRL, these were inarticulate until Flavell and colleagues'…

Optical Detectors for Astronomy II : State-of-the-art at the Turn of the Millennium : 4th ESO CCD Workshop

CERN Document Server

Beletic, James

2000-01-01

th The 4 ESO CCO Workshop, Optical Detectors for Astronomy, was held during September 13-16, 1999 at its usual location, the headquarters of the European Southern Observatory in Garching, Germany. We prefer to remember this workshop as a "meeting of friends", who came to Garching to visit ESO and to present their work, rather than a formal meeting. Based on our experience with the 1996 ESO CCO workshop, we deliberately put emphasis on creating an environment that encouraged the participants to stay together and informally exchange ideas. These informal events began with a tour of the BWM auto factory and continued with a reception at "SchloB Beletic", the conference dinner at a real SchloB of the Bavarian International School (where the participants enjoyed basket, baseball, table soccer, rock climbing and eventually dancing) and concluded with a tour of the Paulaner Brewery and dinner at the Seehaus in the Englisher Garten. The lunch "Biergarten", adjacent to the poster session area, was a daily meeting poin...

Down-regulation of the Th1, Th17, and Th22 pathways due to anti-TNF-α treatment in psoriasis.

Science.gov (United States)

Luan, Li; Han, Shixin; Wang, Hua; Liu, Xiaoming

2015-12-01

Psoriasis is a T-cell-mediated chronic inflammatory dermatosis. Th1, Th17 and Th22 cells are suggested to contribute to the pathogenesis of psoriasis. To determine whether treatment with the anti-tumor-necrosis-factor antagonist, adalimumab, induces significant modulation of the Th1, Th17 and Th22 pathways, and correlates cellular activity with clinical response. This study included 21 patients with moderate-to-severe psoriasis who were treated with adalimumab, and 10 healthy control subjects. Blood samples were collected at baseline and at week 12. Flow cytometry was used to analyze the frequency of circulating Th1, Th17 and Th22 cells. Real-time polymerase chain reaction was used to analyze the expression of T-bet (Th1-related), retinoid-acid receptor-related orphan receptor gamma t (RORγt, Th17-related) and aryl hydrocarbon receptor (AHR, Th22-related). An enzyme-linked immunosorbent assay was used to analyze the serum levels of IFN-γ, IL-17, IL-22, IL-6 and tumor necrosis factor-α (TNF-α). At baseline, the frequencies of Th1, Th17 and Th22 cells were higher in psoriasis patients compared to the healthy controls. The expression of transcription factors T-bet, RORγt and AHR, and the serum levels of IFN-γ, IL-17, IL-22, IL-6 and TNF-α were higher in psoriasis patients compared to the healthy controls. After adalimumab therapy, there was a significant decline in the frequencies of Th1, Th17 and Th22 cells, and a concomitant decrease in the levels of their associated transcription factors and cytokines. The results suggest that the anti-tumor-necrosis-factor antagonist, adalimumab, disrupts the Th1, Th17 and Th22 pathways, resulting in clinical improvement of psoriasis. Copyright © 2015 Elsevier B.V. All rights reserved.

Relevance of Videogames in the Learning and Development of Young Children

Science.gov (United States)

Zhao, Zhuxuan; Linaza-Iglesias, José L.

2015-01-01

Introduction: The study was carried out with children of 2nd, 4th and 6th grades of elementary school in order to explore what and how will children learn from a completely new videogame. Method: We organized children from 2nd, 4th and 6th grades of elemental school, giving them chance to play a freshly released videogame by that time. We formed…

Learning Physics through Project-Based Learning Game Techniques

Science.gov (United States)

Baran, Medine; Maskan, Abdulkadir; Yasar, Seyma

2018-01-01

The aim of the present study, in which Project and game techniques are used together, is to examine the impact of project-based learning games on students' physics achievement. Participants of the study consist of 34 9th grade students (N = 34). The data were collected using achievement tests and a questionnaire. Throughout the applications, the…

Thorium Th

International Nuclear Information System (INIS)

Busev, A.I.; Tiptsova, V.G.; Ivanov, V.M.

1978-01-01

The basic methods for extracting thorium from monazites and determining it photometrically and complexometrically are described. Monazite is decomposed by fusion with sodium peroxide, then thorium and the totality of lanthanides are precipitated in the form of oxalates. After the oxalates have been broken down, thorium is determined photometrically with the aid of arsenazo 1, quercetin of 1-2(-pyridylazo)-resorcin. It takes 25 to 30 minutes to photometrically determine Th in monazites with the aid of arsenazo 2 (error: 3 to 5%). Arsenazo 2 is recommended for analysis of monazites containing 20 to 30% of lanthanides. Arsenazo 3 permits determining Th in zircon and in Nb-containing materials. In this case, the determination is possible in strongly acidic solutions, the ratio of arsenazo 3 to Th being 7.5:1. Arsenazo 3 can also be used in determining trace amounts of Th (1x10 -5 to 1x10 -4 %) in rocks, as well as in extraction-photometric determination of Th traces. The dyed compound of Th with arsenazo 3 is extracted with isoamyl alcohol in the presence of diphenylguanidinium chloride and monochloroacetic acid. The method permits determining Th at 1:5x10 8 (0.002 g/ml) dilution. Also described is the iodate-complexometric method for determining Th

10th Workshop on Self-Organizing Maps

CERN Document Server

Schleif, Frank-Michael; Kaden, Marika; Lange, Mandy

2014-01-01

The book collects the scientific contributions presented at the 10th Workshop on Self-Organizing Maps (WSOM 2014) held at the University of Applied Sciences Mittweida, Mittweida (Germany, Saxony), on July 2–4, 2014. Starting with the first WSOM-workshop 1997 in Helsinki this workshop focuses on newest results in the field of supervised and unsupervised vector quantization like self-organizing maps for data mining and data classification.   This 10th WSOM brought together more than 50 researchers, experts and practitioners in the beautiful small town Mittweida in Saxony (Germany) nearby the mountains Erzgebirge to discuss new developments in the field of unsupervised self-organizing vector quantization systems and learning vector quantization approaches for classification. The book contains the accepted papers of the workshop after a careful review process as well as summaries of the invited talks.   Among these book chapters there are excellent examples of the use of self-organizing maps in agriculture, ...

The Impact of Project-Based Learning on Minority Student Achievement: Implications for School Redesign

Science.gov (United States)

Cervantes, Bernadine; Hemmer, Lynn; Kouzekanani, Kamiar

2015-01-01

Project-Based Learning (PBL) serves as an instructional approach to classroom teaching and learning that is designed to engage students in the investigation of real-world problems to create meaningful and relevant educational experiences. The causal-comparative study compared 7th and 8th students who had utilized the PBL with a comparison group in…

Exploring the Learning Mechanism in Educational Games

OpenAIRE

Kiili, Kristian; Ketamo, Harri

2007-01-01

The main aim of this paper is to evaluate the problem based gaming model that tries to explain the learning process in educational games. The model was studied through Geometry game aimed for pre-school children (N = 24). The game relays on learning by teaching approach and involves AI-engine modeling the human concept learning structures. The qualitative analyses were used to explore participants learning processes and gaming strategies. The results indicated that the model well describes th...

Academic Training: Academic Training Programme 50th Anniversary Lectures

CERN Multimedia

Françoise Benz

2004-01-01

13, 14, 15 & 16 September From 16:30 hrs - Main Auditorium bldg. 500 50 years of research at CERN: from past to future Monday 13 September 50 years of research at CERN: from past to future (Accelerator) (1/4) K. Hubner / CERN-DSU A summary of the evolution of the CERN accelerator complex since the beginning will be given. The emphasis will be on the salient features and highlights and what has been learned at each stage in terms of accelerator physics and technology. Possible future options for CERN based on accelerators will be discussed. Tuesday 14 September 50 years of research at CERN: from past to future (Theory) (2/4) G. Veneziano / CERN-PH-TH Great developments in our understanding of fundamental physics, together with striking technological advances, have repeatedly changed the way CERN/TH has been operating during the past 50 years. I will outline the main 'revolutions' I have myself witnessed at CERN/TH since the mid sixties, and then dare to express expectations, hopes, and fears for how ...

Promoting Learning Achievement, Problem Solving, and Learning Curiosity of High School Students: Empirical Thai Study of Self-directed Learning in Physics Course

Directory of Open Access Journals (Sweden)

Wittaya Worapun

2017-11-01

Full Text Available Three phases of this research were employed to study learning achievement, problem solving, and learning curiosity among 43 students in the 11th grade through self-directed learning in a Physics course. Research instruments included: a learning achievement test, a test of curiosity, observations using anecdotal evidence of curiosity, and a test of problem solving ability. The findings show that six components of self-directed learning were evident, i.e. principles and basic concepts, syntax, social system, principle of reaction, and support system. It was found that five main procedures of self-directed learning were applicable in a management model: diagnosis, strategies, growth in habit, taking action, and summarizing and assessing. Students gained in their learning achievement ; furthermore, their posttest scores in problem solving were greater than their pretest scores at .05 level of statistical significance.

Stability results for a soil model with singular hysteretic hydrology

Czech Academy of Sciences Publication Activity Database

Krejčí, Pavel; O'Kane, J.P.; Pokrovskii, A.; Rachinskii, D.

2011-01-01

Roč. 268, č. 1 (2011), 012016 ISSN 1742-6588. [5th International workshop on multi-rate processes and hysteresis. Pecs , 31.05.2010-03.06.2010] R&D Projects: GA ČR GAP201/10/2315 Institutional research plan: CEZ:AV0Z10190503 Keywords : hysteresis * evolution equation * stability Subject RIV: BA - General Mathematics http://iopscience.iop.org/1742-6596/268/1/012016

Developing Headquarters Guidance for Army Installation Sustainability Plans in 2007

Science.gov (United States)

2009-01-01

references that includes Dancing with the Tiger : Learning Sustainability Step by Natural Step,8 Natural Capitalism: Creating the Next Industrial Revolution...Air Quality Standards for carbon monoxide and coarse particulate matter Seattle Childhood asthma hospitalizations Seattle 102 Developing...September 9, 2007: http://web.uccs.edu/ccps Nattrass, Brian, and Mary Altomare, Dancing with the Tiger : Learning Sustainability Step by Natural

Distributed Practice and Retrieval Practice in Primary School Vocabulary Learning

NARCIS (Netherlands)

N.A.M.C. Goossens (Nicole)

2015-01-01

markdownabstractThe aim of this thesis was to investigate whether particular memory strategies stemming from cognitive and educational psychology, enhance primary school vocabulary learning. Th e memory strategies investigated in this thesis were distributed practice and retrieval practice. Th e

Differential cortical c-Fos and Zif-268 expression after object and spatial memory processing in a standard or episodic-like object recognition task

Directory of Open Access Journals (Sweden)

Flávio F Barbosa

2013-08-01

Full Text Available Episodic memory reflects the capacity to recollect what, where and when a specific event happened in an integrative manner. Animal studies have suggested that the medial temporal lobe and the medial pre-frontal cortex are important for episodic-like memory formation. The goal of present study was to evaluate whether there are different patterns of expression of the immediate early genes c-Fos and Zif-268 in these cortical areas after rats are exposed to object recognition tasks with different cognitive demands. Male rats were randomly assigned to five groups: home cage control (CTR-HC, empty open field (CTR-OF, open field with one object (CTR-OF + Obj, novel object recognition task (OR and episodic-like memory task (ELM and were killed one hour after the last behavioral procedure. Rats were able to discriminate the objects in the OR task. In the ELM task, rats showed spatial (but not temporal discrimination of the objects. We found an increase in the c-Fos expression in the dorsal dentate gyrus (DG and in the perirhinal cortex (PRh in the OR and ELM groups. The OR group also presented an increase of c-Fos expression in the medial prefrontal cortex (mPFC. Additionally, the OR and ELM groups had increased expression of Zif-268 in the mPFC. Moreover, Zif-268 was increased in the dorsal CA1 and perirhinal cortex only in the ELM group. In conclusion, the pattern of activation was different in tasks with different cognitive demands. Accordingly, correlation tests suggest the engagement of different neural networks in the object recognition tasks used. Specifically, perirhinal-dentate gyrus co-activation was detected after the what-where memory retrieval, but not after the novel object recognition task. Both regions correlated with the respective behavioral outcome. These findings can be helpful in the understanding of the neural networks underlying memory tasks with different cognitive demands.

Conditioning Factors for Group Management in Blended Learning Scenarios

NARCIS (Netherlands)

Pérez-Sanagustín, Mar; Hernández-Leo, Davinia; Blat, Josep

2009-01-01

Pérez-Sanagustín, M., Hernández-Leo D., & Blat, J. (accepted). Conditioning Factors for Group Management in Blended Learning Scenarios. The 9th IEEE International Conference on Advanced Learning Technologies. July, 14-18, 2009, Riga, Latvia.

Understanding and reducing student withdrawal in e-learning

OpenAIRE

Marko Radovan

2012-01-01

In this paper we address the problem of student dropout from e-learning programmes. The proponents of e-learning highlight several advantages of this type of education as compared to the traditional, such as greater openness and diversity of training materials, the ability to adjust the mode and speed of learning, and similar. Despite these advantages, an increasing number of programmes and acceptance of e-learning as a national strategy all around the world, e-learning providers also face th...

Th1 and Th2 help for B cells

DEFF Research Database (Denmark)

Poudrier, J; Owens, T

1995-01-01

that IL-5 (125 U/ml) synergizes with Th1 cells to induce B cell responses to IL-2, that are maintained following T-cell removal, e.g. autonomous. Th1 help in the absence of IL-5 resulted in weak or undetectable responses following T cell removal. The mechanism of IL-5 synergy involved persistence of IL-2R...... anti-Ig did not circumvent the need for IL-5 for autonomous IL-2 responses. Consistent with the above, interaction with an IL-5-producing Th2 clone induced strong autonomous B cell responses to IL-2. Qualitative differences of Th2 help over that of Th1 may thus be attributable to their differential...

In vitro Comparative Evaluation of Tensile Bond Strength of 6(th), 7(th) and 8(th) Generation Dentin Bonding Agents.

Science.gov (United States)

Kamble, Suresh S; Kandasamy, Baburajan; Thillaigovindan, Ranjani; Goyal, Nitin Kumar; Talukdar, Pratim; Seal, Mukut

2015-05-01

Newer dentin bonding agents were developed to improve the quality of composite restoration and to reduce time consumption in its application. The aim of the present study was to evaluate tensile bond strength of 6(th), 7(th) and 8(th) generation bonding agents by in vitro method. Selected 60 permanent teeth were assigned into 20 in each group (Group I: 6(th) generation bonding agent-Adper SE plus 3M ESPE, Group II: 7(th) generation bonding agent-G-Bond GC Corp Japan and Group III: 8(th) generation dentin adhesives-FuturaBond, DC, Voco, Germany). With high-speed diamond disc, coronal dentin was exposed, and selected dentin bonding agents were applied, followed by composite restoration. All samples were saved in saline for 24 h and tensile bond strength testing was done using a universal testing machine. The obtained data were tabulated and statistically analyzed using ANOVA test. The tensile bond strength readings for 6(th) generation bonding agent was 32.2465, for 7(th) generation was 31.6734, and for 8(th)-generation dentine bonding agent was 34.74431. The highest tensile bond strength was seen in 8(th) generation bonding agent compared to 6(th) and 7(th) generation bonding agents. From the present study it can be conclude that 8(th) generation dentine adhesive (Futura DC, Voco, Germany) resulted in highest tensile bond strength compared to 6(th) (Adper SE plus, 3M ESPE) and 7(th) generation (G-Bond) dentin bonding agents.

Block Study: Learning About Your Local Community.

Science.gov (United States)

Eckbreth, Catherine

Designed for 7th- and 8th-grade students, five lessons using a block of houses in an urban neighborhood help students learn about the history of a neighborhood, the owners of the houses, and the style and architectural features of the homes. Although this unit has been developed for a specific neighborhood, a similar block study could be conducted…

The Contribution of Learning Outcomes for Listening to Creative Thinking Skills

Science.gov (United States)

Aldig, Ebru; Arseven, Ayla

2017-01-01

This study aims to examine teacher's opinions on the contribution of learning outcomes for listening defined in the Ministry of National Education's Turkish course curriculum for the 6th, 7th and 8th grades to the development of creative thinking skills. Mixed methods research design was adopted in the study. As the quantitative part of the study,…

11th Workshop on Self-Organizing Maps

CERN Document Server

Mendenhall, Michael; O'Driscoll, Patrick

2016-01-01

This book contains the articles from the international conference 11th Workshop on Self-Organizing Maps 2016 (WSOM 2016), held at Rice University in Houston, Texas, 6-8 January 2016. WSOM is a biennial international conference series starting with WSOM'97 in Helsinki, Finland, under the guidance and direction of Professor Tuevo Kohonen (Emeritus Professor, Academy of Finland). WSOM brings together the state-of-the-art theory and applications in Competitive Learning Neural Networks: SOMs, LVQs and related paradigms of unsupervised and supervised vector quantization. The current proceedings present the expert body of knowledge of 93 authors from 15 countries in 31 peer reviewed contributions. It includes papers and abstracts from the WSOM 2016 invited speakers representing leading researchers in the theory and real-world applications of Self-Organizing Maps and Learning Vector Quantization: Professor Marie Cottrell (Universite Paris 1 Pantheon Sorbonne, France), Professor Pablo Estevez (University of Chile and ...

Motivating Students for Project-based Learning for Application of Research Methodology Skills.

Science.gov (United States)

Tiwari, Ranjana; Arya, Raj Kumar; Bansal, Manoj

2017-12-01

Project-based learning (PBL) is motivational for students to learn research methodology skills. It is a way to engage and give them ownership over their own learning. The aim of this study is to use PBL for application of research methodology skills for better learning by encouraging an all-inclusive approach in teaching and learning rather than an individualized tailored approach. The present study was carried out for MBBS 6 th - and 7 th -semester students of community medicine. Students and faculties were sensitized about PBL and components of research methodology skills. They worked in small groups. The students were asked to fill the student feedback Questionnaire and the faculty was also asked to fill the faculty feedback Questionnaire. Both the Questionnaires were assessed on a 5 point Likert scale. After submitted projects, document analysis was done. A total of 99 students of the 6 th and 7 th semester were participated in PBL. About 90.91% students agreed that there should be continuation of PBL in subsequent batches. 73.74% felt satisfied and motivated with PBL, whereas 76.77% felt that they would be able to use research methodology in the near future. PBL requires considerable knowledge, effort, persistence, and self-regulation on the part of the students. They need to devise plans, gather information evaluate both the findings, and their approach. Facilitator plays a critical role in helping students in the process by shaping opportunity for learning, guiding students, thinking, and helping them construct new understanding.

Reading across Workplace Learning Research to Build Dialogue

Science.gov (United States)

Sawchuk, Peter H.

2010-01-01

The field of workplace learning scholarship in Western countries is reviewed. First, the emergence of workplace learning scholarship is discussed historically for its relation to the emergence and ongoing development of capitalism beginning from early thought on markets and productivity, 20th century scientific management, industrialism and…

The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice.

Science.gov (United States)

Li, Xia; Wang, Bin; Li, Yuzhu; Wang, Li; Zhao, Xiangzhong; Zhou, Xianbin; Guo, Yuqi; Jiang, Guosheng; Yao, Chengfang

2013-01-09

The Th1/Th2/Th17/Treg paradigm plays an important role in achieving maternal-fetal immunotolerance and participates in RU486-induced abortion. Excessive uterine bleeding is the most common side effect of RU486-induced abortion; however, its etiopathogenesis has not been fully understood. Therefore, elucidating the correlation between the Th1/Th2/Th17/Treg paradigm and the volume of uterine bleeding may offer novel therapeutic target for reducing uterine bleeding in RU486-induced abortion. Leonurus sibiricus has been used in clinics to reduce postpartum hemorrhage with low toxicity and high efficiency; however, the effective constituents and therapeutic mechanism have not been described. Stachydrine hydrochloride is the main constituent of L. sibiricus, therefore L. sibiricus is regarded as a candidate for reducing uterine bleeding in RU486-induced abortion mice by regulating the Th1/Th2/Th17/Treg paradigm. The purpose of this study was to determine the Th1/Th2/Th17/Treg paradigm in uterine bleeding of RU486-induced abortion mice and to elucidate the immunopharmacologic effects of stachydrine hydrochloride on inducing the Th1/Th2/Th17/Treg paradigm in reducing the uterine bleeding volume in RU486-induced abortion mice. To investigate the Th1/Th2/Th17/Treg paradigm in uterine bleeding during RU486-induced abortion mice, pregnant BALB/c mice were treated with high- and low-dose RU486 (1.5mg/kg and 0.9 mg/kg, respectively), and the serum progesterone (P(4)) protein level, uterine bleeding volume, and proportions of Th1/Th2/Th17/Treg cells in mice at the maternal-fetal interface were detected by ELISA assay, alkaline hematin photometric assay, and flow cytometry, respectively. To determine the regulatory effect of stachydrine hydrochloride on the Th1/Th2/Th17/Treg paradigm in vitro, splenocytes of non-pregnant mice were separated and treated with P(4,) RU486, and/or stachydrine hydrochloride (10(-5)M, 10(-4)M, and 10(-3)M, respectively). The proportions of Th1/Th2/Th17

Activated rat hepatic stellate cells influence Th1/Th2 profile in vitro.

Science.gov (United States)

Xing, Zhi-Zhi; Huang, Liu-Ye; Wu, Cheng-Rong; You, Hong; Ma, Hong; Jia, Ji-Dong

2015-06-21

To investigate the effects of activated rat hepatic stellate cells (HSCs) on rat Th1/Th2 profile in vitro. Growth and survival of activated HSCs and CD4(+) T lymphocytes cultured alone or together was assessed after 24 or 48 h. CD4(+) T lymphocytes were then cultured with or without activated HSCs for 24 or 48 h and the proportion of Th1 [interferon (IFN)-γ(+)] and Th2 [interleukin (IL)-4(+)] cells was assessed by flow cytometry. Th1 and Th2 cell apoptosis was assessed after 24 h of co-culture using a caspase-3 staining procedure. Differentiation rates of Th1 and Th2 cells from CD4(+) T lymphocytes that were positive for CD25 but did not express IFN-γ or IL-4 were also assessed after 48 h of co-culture with activated HSCs. Galectin-9 expression in HSCs was determined by immunofluorescence and Western blotting. ELISA was performed to assess galectin-9 secretion from activated HSCs. Co-culture of CD4(+) T lymphocytes with activated rat HSCs for 48 h significantly reduced the proportion of Th1 cells compared to culture-alone conditions (-1.73% ± 0.71%; P Th1/Th2 ratio was significantly decreased (-0.44 ± 0.13; P Th1 cells was decreased (-65.71 ± 9.67; P Th1 (12.27% ± 0.99%; P Th1 cell apoptosis rate was significantly higher than in Th2 cells (P Th1 and Th2 cells; however, the increase in the proportion of Th2 cells was significantly higher than that of Th1 cells (1.85% ± 0.48%; P Th1/Th2 profile, inhibiting the Th1 response and enhancing the Th2 response, and this may be a novel pathway for liver fibrogenesis.

The role of Th1 and Th17 cells in glomerulonephritis.

Science.gov (United States)

Azadegan-Dehkordi, Fatemeh; Bagheri, Nader; Shirzad, Hedayatollah; Rafieian-Kopaei, Mahmoud

2015-04-01

T helper (Th) cells as an important part of the immune is responsible for elimination of invading pathogens. But, if Th cell responses are not regulated effectively, the autoimmune diseases might develop. The Th17 subset usually produces interleukin-17A which in experimental models of organ-specific autoimmune inflammation is very important. Directory of open access journals (DOAJ), Google Scholar, Embase, Scopus, PubMed and Web of Science have been searched. Fifty-six articles were found and searched. In the present review article, we tried to summarize the recently published data about characteristics and role of Th1 and Th17 cells and discuss in detail, the potential role of these T helpers immune responses in renal inflammation and renal injury, focusing on glomerulonephritis. Published papers in animal and human studies indicated that autoimmune diseases such as rheumatoid arthritis and multiple sclerosis, classically believed to be Th1-mediated, are mainly derived from a Th17 immune response. Identification of the Th17 subgroup has explained seemingly paradoxical observations and improved our understanding of immune-mediated inflammatory responses. Secretion of IL-17A, as well as IL-17F, IL-21, IL-22, suggests that Th17 subset may play a crucial role as a pleiotropic pro-inflammatory Th subset. There is experimental evidence to support the notion that Th1 and Th17 cells contribute to kidney injury in renal inflammatory diseases like glomerulonephritis.

6th International Conference on Practical Applications of Computational Biology & Bioinformatics

CERN Document Server

Luscombe, Nicholas; Fdez-Riverola, Florentino; Rodríguez, Juan; Practical Applications of Computational Biology & Bioinformatics

2012-01-01

The growth in the Bioinformatics and Computational Biology fields over the last few years has been remarkable.. The analysis of the datasets of Next Generation Sequencing needs new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Also Systems Biology has also been emerging as an alternative to the reductionist view that dominated biological research in the last decades. This book presents the results of the  6th International Conference on Practical Applications of Computational Biology & Bioinformatics held at University of Salamanca, Spain, 28-30th March, 2012 which brought together interdisciplinary scientists that have a strong background in the biological and computational sciences.

HSCI2014: booklet of the 11th International Conference on Hands-on Science

OpenAIRE

Costa, Manuel F. M., ed. lit.; Pombo, José Miguel Marques, ed. lit.; Vázquez Dorrío, José Benito, ed. lit.; International Conference on Hands-on Science, 11, Aveiro, 2014

2014-01-01

The core topic of the 11th Hands-on Science Conference is "Science Education with and for Society" As we all know it is the Society that sets the requirements rules and procedures of Education. It is Society that defines what citizens must learn in what concern either concepts and or competencies, and how this learning can, must in fact…, take place. Society is the ensemble of all of us citizens and of all the structures tangible and intangible we create and created along the y...

What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?

Directory of Open Access Journals (Sweden)

Campos-Neto A.

2005-01-01

Full Text Available The T helper cell type 1 (Th1 response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine.

The Effect of Active Learning Approach on Attitudes of 7th Grade Students

Science.gov (United States)

Demirci, Cavide

2017-01-01

Active learning is a student's active impact on learning and a student's involvement in the learning process which allows students to focus on creating knowledge with an emphasis on skills such as analytical thinking, problem-solving and meta-cognitive activities that develop students' thinking. The main purpose of this study is to determine…

Determination of 228Th, 230Th, and 232Th in environmental samples from uranium mining and milling operations

International Nuclear Information System (INIS)

Durham, R.W.; Joshi, S.R.

1979-01-01

A method is described for the determination of 228 Th, 230 Th, and 232 Th in environmental samples from uranium mining and milling operations. The analytical procedure is based on the direct determination of 228 Th in the sample by high resolution γ-spectrometry followed by extraction and purification of the thorium fraction using high molecular weight amines and an anion-exchange technique, respectively, prior to α-spectrometry to determine isotopic ratios. The lowest level of detection for each thorium isotope is 0.01 pCi/g for solid samples and 20 pCi/l for aqueous samples. Replicate analyses of a typical mine waste stream gave a standard deviation of +-3% for 228 Th. Standard deviations of the 230 Th and 232 Th increased to +-11% apparently due to traces of 210 Po interfering in the α-spectrometry. (author)

Implementation of Case-Based Instruction on Electrochemistry at the 11th Grade Level

Science.gov (United States)

Tarkin, Aysegul; Uzuntiryaki-Kondakci, Esen

2017-01-01

This study aims to compare the effectiveness of case-based instruction over traditional instruction in improving 11th grade students' understanding of electrochemistry concepts, attitudes toward chemistry, chemistry self-efficacy beliefs, and motivation to learn chemistry. In total, 113 students (47 males and 66 females) from three high schools…

Learning Analytics: drivers, developments and challenges

Directory of Open Access Journals (Sweden)

Rebecca Ferguson

2014-12-01

Full Text Available Learning analytics is a significant area of Technology-Enhanced Learning (TEL that has emerged during the last decade. This review of the field begins with an examination of the technological, educational and political factors that have driven the development of analytics in educational settings. It goes on to chart the emergence of learning analytics, including their origins in the 20th century, the development of data-driven analytics, the rise of learning-focused perspectives and the influence of national economic concerns. It next focuses on the relationships between learning analytics, educational data mining and academic analytics. Finally, it examines developing areas of learning analytics research, and identifies a series of future challenges.

A Problem-Based Learning Scenario That Can Be Used in Science Teacher Education

Science.gov (United States)

Sezgin Selçuk, Gamze

2015-01-01

The purpose of this study is to introduce a problem-based learning (PBL) scenario that elementary school science teachers in middle school (5th-8th grades) can use in their in-service training. The scenario treats the subjects of heat, temperature and thermal expansion within the scope of the 5th and 6th grade science course syllabi and has been…

Proceedings of the 6th Computer Science On-line Conference 2017

CERN Document Server

Senkerik, Roman; Oplatkova, Zuzana; Prokopova, Zdenka; Silhavy, Petr

2017-01-01

This book presents new methods and approaches to real-world problems as well as exploratory research that describes novel artificial intelligence applications, including deep learning, neural networks and hybrid algorithms. This book constitutes the refereed proceedings of the Artificial Intelligence Trends in Intelligent Systems Section of the 6th Computer Science On-line Conference 2017 (CSOC 2017), held in April 2017. .

Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161(+)Th1 Cells) to CD161(+)Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients.

Science.gov (United States)

Kotake, Shigeru; Nanke, Yuki; Yago, Toru; Kawamoto, Manabu; Kobashigawa, Tsuyoshi; Yamanaka, Hisashi

2016-01-01

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of articular cartilage and bone with elevated levels of proinflammatory cytokines. It has been reported that IL-17 and Th17 cells play important roles in the pathogenesis of RA. Recently, plasticity in helper T cells has been demonstrated; Th17 cells can convert to Th1 cells. It remains to be elucidated whether this conversion occurs in the early phase of RA. Here, we tried to identify Th17 cells, Th1 cells, and Th17 cell-derived Th1 cells (CD161(+)Th1 cells) in the peripheral blood of early-onset RA patients. We also evaluated the effect of methotrexate on the ratio of Th17 cells in early-onset RA patients. The ratio of Th17 cell-derived Th1 cells to CD161(+)Th17 cells was elevated in the peripheral blood of early-onset RA patients. In addition, MTX reduced the ratio of Th17 cells but not Th1 cells. These findings suggest that IL-17 and Th17 play important roles in the early phase of RA; thus, anti-IL-17 antibodies should be administered to patients with RA in the early phase.

An Analysis of Think Globally-Act Locally Strategy Implementation in Developing Relationship of Headquarters and Subsidiaries: Case Study of John Clements Consultants Inc., Philippines & Indonesia

Directory of Open Access Journals (Sweden)

Dilla Noverita

2007-01-01

Moreover, this research analyses how JCCI applies “think globally – act locally” strategy in its global operations and developing relationship with subsidiaries. It brings the issues of all challenges and obstacles the company has in dealing with subsidiaries. Finally, this research recommends alternative strategies to leverage the relationship between headquarters and subsidiaries more efficiently and to minimize the obstacles in cross-cultural management so that the company will be able to strengthen its position in global service market.

ARLearn - Open source mobile application platform for learning

NARCIS (Netherlands)

Börner, Dirk; Ternier, Stefaan; Klemke, Roland; Schmitz, Birgit; Kalz, Marco; Tabuenca, Bernardo; Specht, Marcus

2013-01-01

Börner, D., Ternier, S., Klemke, R., Schmitz, B., Kalz, M., Tabuenca, B., & Specht, M. (2013). ARLearn - Open source mobile application platform for learning. In D. Hernández-Leo et al. (Eds.), Scaling up Learning for Sustained Impact. Proceedings of the 8th European Conference on Technology

Effect of ambulatory medicine tutorial on clinical performance of 5th year medical students.

Science.gov (United States)

Phisalprapa, Pochamana; Pandejpong, Denla

2013-02-01

The present study provided a group learning activity called "Ambulatory Medicine Tutorial-AMT" for 5th year medical students in order to facilitate learning experience at ambulatory setting and to improve medical students' clinical performance. This research aimed specifically to study the effect of AMT. Two groups of twenty 5th-year medical students were enrolled during their ambulatory medicine blocks. Each medical student was assigned to have 8 ambulatory sessions. AMT was assigned to one group while the other group only used conventional learning activity. At the end of the present study, total internal medicine scores, patient satisfaction surveys, and data on average time spent on each clinical encounter were collected and compared. The AMT group received a higher total internal medicine score as compared to the conventional group (76.2 +/- 3.6 vs. 72.9 +/- 2.8, p = 0.003). The AMT group could reduce average time spent on each clinical encounter within their first-6 ambulatory sessions while the conventional group could acquire the same skill later in their last 2 ambulatory sessions. There was no significant difference found on comparing patient satisfaction scores between the 2 groups. AMT helped improving medical students' outcomes as shown from higher total internal medicine score as well as quicker improvement during real-life clinical encounters, AMT could be a good alternative learning activity for medical students at ambulatory setting.

Knowledge and Learning in Engineering Practice

DEFF Research Database (Denmark)

Buch, Anders

2007-01-01

, this chapter discusses the cencept of learning and purports to theorize learning in a Social Theory of Learning (STL). The attempt to reconstruct learning in an STL addresses three main issues: an STL must try to specify the subject-world relationship, describe the 'mechanism' of learning, and identify......During the 20th century, traditional epistemological theories of knowledge have been under siege. In recent years, efforts have been made to reconstruct the concept of 'knowledge' to emphasize its contextual, situated and social character. Drawing on the results and methods of these efforts...... the 'telos' of learning. This attempt will in fact give answers to three fundamental questions: 1) What is learning? 2) How do we learn? and 3) Why do we learn? These questions are discussed in relation to engineering practices of getting to know and learning....

78 FR 23622 - National Small Business Development Center Advisory Board

Science.gov (United States)

2013-04-19

.... SUMMARY: The SBA is issuing this notice to announce the location, date, time and agenda for the 3rd...--Face to Face meeting. Address will be SBA Headquarters, 409 Third Street SW., OED Conference Room, 6th... due to a last minute opportunity to pull everyone together for a face to face meeting on April 16th...

Th1-Th17 Ratio as a New Insight in Rheumatoid Arthritis Disease.

Science.gov (United States)

Bazzazi, Hadi; Aghaei, Mehrdad; Memarian, Ali; Asgarian-Omran, Hossein; Behnampour, Nasser; Yazdani, Yaghoub

2018-02-01

The Th17, Th1 and dual Th17/Th1 cells are important players in rheumatoid arthritis (RA) disease. To assess their roles, the frequency and impact of these cells were investigated in patients with different disease activity. In 14 new cases and 41 established RA patients in comparison with 22 healthy controls, the percentages of Th17, Th1 and dual Th17/Th1 cells were determined by flow-cytometry and their correlations were investigated with disease activity score (DAS28). Moreover, serum levels of IL-6 and IL-17 as inducer and functional cytokines for Th17 were investigated. Finally, serum levels of anti citrullinated protein antibody (ACPA) and rheumatoid factor (RF) were assessed. Percentage of Th17 cells in RA patients were increased in comparison with healthy controls (pTh1 cells in RA patients were less than healthy group (pTh17/Th1 cell only in new cases of RA were more than healthy control groups (pTh1/Th17 ratio in RA patients is statistically different with healthy control group (pTh1/Th17 ratio in RA patient suggested a new paradigm in the field of autoimmune disease and indicated that imbalance or plasticity between these subsets can be important in progress, diagnosis and therapy of RA disease.

IMS Learning Design Support for the Formalization of Collaborative Learning Patterns

NARCIS (Netherlands)

Hernández-Leo, Davinia; Asensio-Pérez, Juan; Dimitriadis, Yannis

2004-01-01

The paper was granted with "an ICALT Best Paper Award". Appears in Proceedings of the 4th International Conference on Advanced Learning Technologies (ICALT04), pp. 350-354, Joensuu, Finland, 31 Aug - 1 Sep 2004. (source link).

Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells.

Science.gov (United States)

Riaz, Tahira; Sollid, Ludvig Magne; Olsen, Ingrid; de Souza, Gustavo Antonio

2016-03-01

T-helper cells are differentiated from CD4+ T cells and are traditionally characterized by inflammatory or immunosuppressive responses in contrast to cytotoxic CD8+ T cells. Mass-spectrometry studies on T-helper cells are rare. In this study, we aimed to identify the proteomes of human Th1 and Th1/Th17 clones derived from intestinal biopsies of Crohn's disease patients and to identify differentially expressed proteins between the two phenotypes. Crohn's disease is an inflammatory bowel disease, with predominantly Th1- and Th17-mediated response where cells of the "mixed" phenotype Th1/Th17 have also been commonly found. High-resolution mass spectrometry was used for protein identification and quantitation. In total, we identified 7401 proteins from Th1 and Th1/Th17 clones, where 334 proteins were differentially expressed. Major differences were observed in cytotoxic proteins that were overrepresented in the Th1 clones. The findings were validated by flow cytometry analyses using staining with anti-granzyme B and anti-perforin and by a degranulation assay, confirming higher cytotoxic features of Th1 compared with Th1/Th17 clones. By testing a larger panel of T-helper cell clones from seven different Crohn's disease patients, we concluded that only a subgroup of the Th1 cell clones had cytotoxic features, and these expressed the surface markers T-cell-specific surface glycoprotein CD28 and were negative for expression of natural killer group 2 member D. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Modelo natural de dicotomía TH1-TH2: La enfermedad de Hansen Th1-TH2 balance. Natural model: Hansen'disease

Directory of Open Access Journals (Sweden)

N. L Vaquero

2010-09-01

Full Text Available La enfermedad de Hansen producida por el Mycobacterium leprae, es una enfermedad infecciosa cuyo amplio espectro clínico e inmunopatológico se correlaciona con los diferentes patrones de respuesta Th1/Th2. La activación preferencial de esas subpoblaciones de linfocitos T CD4 juega un rol importante en su patogenia y constituye un modelo natural de esa dicotomía de la respuesta inmune. Ambas formas polares de la lepra presentan un perfil definido de secreción de citoquinas: Th1 (IL2 e IFN? en el polo tuberculoide y Th2 (IL4, IL5, IL10 en el polo lepromatoso. En el primer caso, la respuesta celular adecuada estimula la activación macrofágica y lleva a la destrucción del bacilo. Las lesiones son escasas y limitadas a la piel y nervios periféricos. En el segundo en cambio, la respuesta celular es casi nula y los bacilos se multiplican descontroladamente dentro de los macrófagos, llevando a la diseminación de las lesiones y afectación de otros órganos. La inmunidad humoral está exacerbada y hay un alto nivel de anticuerpos que no pueden eliminar el germen intracelular. Los factores que determinan la diferenciación hacia una respuesta Th1 ó Th2 no se han esclarecido totalmente. Se han postulado varias hipótesis que hacen referencia a factores genéticos, prevalencia de citoquinas en el microambiente celular, disfunción macrofágica; alteración en los receptores Toll de la inmunidad innata, en la expresión de moléculas coestimulatorias, etc En los últimos años se han descubierto nuevas subpoblaciones de linfocitos, (CD4+ CD25+, Tr1, Th3 y Th17 que estarían implicadas en la desregulación de estas respuestas inmunes.Hansen' disease, caused by Mycobacterium leprae, is an infectious illness whose wide clinical and immunopathologic spectrum correl with different Th1/Th2 responses patterns. The prefferencial activation of the CD4 T cells subset play an important rol in it's pathogenia and provides a natural model of that balance

International Workshop on Evidence-Based Technology Enhanced Learning

CERN Document Server

Gennari, Rosella; Marenzi, Ivana; Prieta, Fernando; Rodríguez, Juan

2012-01-01

Research on Technology Enhanced Learning (TEL) investigates how information and communication technologies can be designed in order to support pedagogical activities. The workshop proceedings collects contributions concerning evidence based TEL systems, like their design following EBD principles as well as studies or best practices that educators, education stakeholders or psychologists used to diagnose or improve their students' learning skills, including students with specific difficulties. The international ebTEL’12 workshop wants to be a forum in which TEL researchers and practitioners alike can discuss ideas, projects, and lessons related to ebTEL. The workshop takes place in Salamanca, Spain, on March 28th-30th 2012.  

Report on the 19th SPACE Conference = 10. mednarodna konferenca SPACE

Directory of Open Access Journals (Sweden)

Rune Gulev

2008-06-01

Full Text Available The 19th international space (European Network for Business Studies and Languages conference that recently took place in Spain provided valuable insight into several areas of interest. Most notably, methods on how to successfully enhance the internationalization of higher learning institutions were shared through mobility and joint degrees programs. Furthermore, the conference provided an academic forum for a highly professional and earnest discourse on pertinent topics of relevance for higher learning institutions, which this year pivoted around intercultural awareness and dialogue. In sum, the space network provides a wealth of academic and administrative advantages that the academic sphere could greatly benefit from.

The didactic situation in geometry learning based on analysis of learning obstacles and learning trajectory

Science.gov (United States)

Sulistyowati, Fitria; Budiyono, Slamet, Isnandar

2017-12-01

This study aims to design a didactic situation based on the analysis of learning obstacles and learning trajectory on prism volume. The type of this research is qualitative and quantitative research with steps: analyzing the learning obstacles and learning trajectory, preparing the didactic situation, applying the didactic situation in the classroom, mean difference test of problem solving ability with t-test statistic. The subjects of the study were 8th grade junior high school students in Magelang 2016/2017 selected randomly from eight existing classes. The result of this research is the design of didactic situations that can be implemented in prism volume learning. The effectiveness of didactic situations that have been designed is shown by the mean difference test that is the problem solving ability of the students after the application of the didactic situation better than before the application. The didactic situation that has been generated is expected to be a consideration for teachers to design lessons that match the character of learners, classrooms and teachers themselves, so that the potential thinking of learners can be optimized to avoid the accumulation of learning obstacles.

Analysis of Primary School Student's Science Learning Anxiety According to Some Variables

Science.gov (United States)

Karakaya, Ferhat; Avgin, Sakine Serap; Kumperli, Ethem

2016-01-01

On this research, it is analyzed if the science learning anxiety level shows difference according to variables which are gender, grade level, science lesson grade, mother education, father education level. Scanning Design is used for this study. Research working group is consisted of 294 primary school from 6th, 7th and 8th graders on 2015-2016…

TCAMS lessons learned

Energy Technology Data Exchange (ETDEWEB)

Harris, D. [Sandia National Labs., Albuquerque, NM (United States)

1997-11-01

This report contains viewgraphs on the CINC mobile alternate headquarters and the tech control automation, maintenance and support facility. A discussion on software cost reduction by reuse is given as well as managing risk by assessment and mitigation.

Engaging 5th/6th Graders in Representations of Change Over Time in the Context of Adaptations to Climate Change in the Gulf of Maine

Science.gov (United States)

Peake, L.; Young Morse, R.

2017-12-01

Since 2005, the Gulf of Maine Research Institute has brought 70% of Maine's 5th/6th grade cohort annually to our marine research lab for a 2.5-hour exploration of ecosystem complexity. Using a digital platform, tools of science, and live marine species, students consider the interconnections among key Gulf of Maine species while experiencing the process of authentic marine research. With funding from NASA, we are renovating the program's learning content, underlying technology, and physical interfaces to leverage NASA data sets. The new experience will emphasize development of students' data skills as they investigate the impacts of climate change in the Gulf of Maine. To do this, students will explore representations of rising ocean temperatures and connect that to representations of changes in the populations of key species like lobster and black sea bass. Past experience suggests the abstraction and synthesis required to make meaning from data visualizations is extremely challenging for this age student. We will report on an early round of informal testing with 250+ students to understand their ability to extract meaning from geospatial and graphical representations of change over time. We will also report on experiments that will be conducted in Fall 2017 to understand the kinds of informal learning experiences, and the sequences of data representations, that best support growth in students' ability to interpret a range of representations. Finally, we will discuss the project's work to extend the learning experiences 1) back into the classroom, including through citizen science; and 2) out to regional science centers for adaptation to investigations of local climate impacts.

8th Chinese Conference on The Semantic Web and Web Science

CERN Document Server

Du, Jianfeng; Wang, Haofen; Wang, Peng; Ji, Donghong; Pan, Jeff Z; CSWS 2014

2014-01-01

This book constitutes the thoroughly refereed papers of the 8th Chinese Conference on The Semantic Web and Web Science, CSWS 2014, held in Wuhan, China, in August 2014. The 22 research papers presented were carefully reviewed and selected from 61 submissions. The papers are organized in topical sections such as ontology reasoning and learning; semantic data generation and management; and semantic technology and applications.

Rapid Wall-Breaching Kit, Ingress Hole Determination Experiment

National Research Council Canada - National Science Library

Turner, Daniel D; Carstens, Christian B; Redden, Elizabeth S; Whalen, Joseph B

2003-01-01

.... The experiment was conducted at McKenna Military Operations in Urban Terrain (MOUT) site Ft. Benning, Georgia. Soldiers from the Ranger Training Brigade and Headquarters Company 3/11th Infantry participated in the experiment...

Learning Strategies of Physics Teacher Candidates: Relationships with Physics Achievement and Class Level

Science.gov (United States)

Selçuk, Gamze S.; Çalişkan, Serap; Erol, Mustafa

2007-04-01

Learning strategy concept was introduced in the education field from the development of cognitive psychology. Learning strategies are behaviors and thoughts that a learner engages in during learning which are intended to influence the learner's encoding process. Literature on learning strategies in physics field is very scarce. Participants of the research consist of teacher candidates (n=137) from 1st, 2nd, 3rd, 4th and 5th grade attending Department of Physics Education, Education Faculty of Buca, Dokuz Eylül University in Turkey. Data of this research was collected by ``Scale of Learning Strategies Usage in Physics'' (Cronbach's Alpha=0.93). Mean, Standard Deviation, Analysis of Variance were used to analyze the research data. This paper reports on teacher candidates' learning strategies used in physics education The paper investigates the relationships between learning strategies and physics achievement, class level. Some important outcomes of the research are presented, discussed and certain suggestions are made.

Problems in the Deployment of Learning Networks In Small Organizations

NARCIS (Netherlands)

Shankle, Dean E.; Shankle, Jeremy P.

2006-01-01

Please, cite this publication as: Shankle, D.E., & Shankle, J.P. (2006). Problems in the Deployment of Learning Networks In Small Organizations. Proceedings of International Workshop in Learning Networks for Lifelong Competence Development, TENCompetence Conference. March 30th-31st, Sofia, Bulgaria:

6th year of the MEFANET conference brought new ideas for the education of future health professionals

Directory of Open Access Journals (Sweden)

Lenka Šnajdrová

2013-05-01

Full Text Available The 6th year of the MEFANET conference was held in Brno, Czech Republic, from Tuesday 27th to Wednesday 28th November 2012. This conference provides a regular opportunity for teachers and students from medical faculties from all over the Czech Republic and Slovakia to meet experts in health care informatics and providers of electronical support in the education. Apart from methodical and educational aspects of e-learning at medical faculties in general, this year’s conference has again dealt with the impact of this phenomenon on a specific medical specialty: a thematically focused symposium addressed the fields of orthopaedics, rheumatology and physiotherapy.

Searching for Buried Treasure: Uncovering Discovery in Discovery-Based Learning

Science.gov (United States)

Chase, Kiera; Abrahamson, Dor

2018-01-01

Forty 4th and 9th grade students participated individually in tutorial interviews centered on a problem-solving activity designed for learning basic algebra mechanics through diagrammatic modeling of an engaging narrative about a buccaneering giant burying and unearthing her treasure on a desert island. Participants were randomly assigned to…

Comparison between project-based learning and discovery learning toward students' metacognitive strategies on global warming concept

Science.gov (United States)

Tumewu, Widya Anjelia; Wulan, Ana Ratna; Sanjaya, Yayan

2017-05-01

The purpose of this study was to know comparing the effectiveness of learning using Project-based learning (PjBL) and Discovery Learning (DL) toward students metacognitive strategies on global warming concept. A quasi-experimental research design with a The Matching-Only Pretest-Posttest Control Group Design was used in this study. The subjects were students of two classes 7th grade of one of junior high school in Bandung City, West Java of 2015/2016 academic year. The study was conducted on two experimental class, that were project-based learning treatment on the experimental class I and discovery learning treatment was done on the experimental class II. The data was collected through questionnaire to know students metacognitive strategies. The statistical analysis showed that there were statistically significant differences in students metacognitive strategies between project-based learning and discovery learning.

A Study on Developing Learning Strategies in Violin Education

Science.gov (United States)

Afacan, Senol; Cilden, Seyda

2018-01-01

This study was conducted for the purpose of developing a valid and reliable learning strategies scale for students receiving violin education in Departments of Music at Fine Arts High Schools. The scale was applied to 391 violin students receiving education in the 11th and 12th grades in Departments of Music at Fine Arts High Schools in the…

International Exchanges as a Learning Tool

DEFF Research Database (Denmark)

Austring, Bennye Düranc; Schlüntz, Ditte Annette

The project focused on the learning outcome of three one-week camps in Latvia, Denmark and Poland, where about 40 8th grade students each place were working with art based activities like dance, song writing, DJ'ing and circus. Especially these six objectives were measured on: Foreign language sp...... speaking, Knowledge about other countries, Understanding od democracy and human rights, Personal development, Art-based learning benefits and Inclusion and motivation of young people. The positive development of 'knowledge of other countries' was the most eye-catching learning outcome....

77 FR 27771 - Environmental Impacts Statements; Notice of Availability

Science.gov (United States)

2012-05-11

... all requirements for EIS filing, eliminating the need to submit paper copies to EPA Headquarters, by..., Contact: Alex Stone 619-545-8128. EIS No. 20120144, Draft EIS, USAF, CA, F-15 Aircraft Conversion, 144th...

Relics of continental lithosphere in the atlantic by data of (Th/U)th, (Th/U)pb, and K/Ti systematics

International Nuclear Information System (INIS)

Titayeva, N.A.; Mironov, Y.

1996-01-01

The problem of mantle heterogeneity of the Atlantic Ocean has been investigated. Th/U ratio is a sensitive geochemical tracer. This ratio can be calculated from 232Th/230Th or from 208Pb/206Pb since 230Th and 206Pb are decay product of 238U and 208Pb is a product of 232Th decay. The former way to get Th/U ratio is valid for quaternary volcanic rocks because of the relatively short 230Th half life (80000 years), the latter way gives an integral quantity characterizing the pre-oceanic history beginning from the onset of earth formation and ending about 150 million years ago. Clear distinctions between ''depleted oceanic'' and ''enriched continental'' reservoirs have been drawn from comparative analysis of rocks. (A.C.)

X-ray spectral study of the Th6p,5f electron states in ThO2 and ThF4

International Nuclear Information System (INIS)

Teterin, Y.A.; Nikitin, A.S.; Teterin, A.Y.; Ivanov, K.E.; Utkin, I.O.; Nerehov, V.A.; Ryzhkov, M.V.; Vukchevich, I.J.

2002-01-01

The study of the Th6p,5f electron states in Th, ThO 2 and ThF was carried out on the basis of the X-ray photoelectron fine spectral structure parameters in the binding energy range of 0-∼ 1000 eV, X-ray O 4,5 (Th) emission spectra of the shallow (0-∼50 eV) electrons and results of theoretical calculations. As a result, despite the absence of the Th5f electrons in thorium atoms, the Th5f atomic orbitals were established to participate in the formation of molecular orbitals in thorium dioxide and tetrafluoride. In the MO LCAO approximation this allowed to suggest the possible existence of filled Th5f electronic states in thorium compounds. On the basis of the X-ray O 4,5 (Th) emission spectral structure parameters the effective formation of the inner valence molecular orbitals in the studied compounds was confirmed. (authors)

Interactive Multimodal Molecular Set – Designing Ludic Engaging Science Learning Content

DEFF Research Database (Denmark)

Thorsen, Tine Pinholt; Christiansen, Kasper Holm Bonde; Jakobsen Sillesen, Kristian

2014-01-01

This paper reports on an exploratory study investigating 10 primary school students’ interaction with an interactive multimodal molecular set fostering ludic engaging science learning content in primary schools (8th and 9th grade). The concept of the prototype design was to bridge the physical...... and virtual worlds with electronic tags and, through this, blend the familiarity of the computer and toys, to create a tool that provided a ludic approach to learning about atoms and molecules. The study was inspired by the participatory design and informant design methodologies and included design...

Modelling self-efficacy, self-regulation, self-directed learning and career processes of adult professionals and relations with learning outcomes and labour market success

NARCIS (Netherlands)

Bijker, Monique; Van der Klink, Marcel; Boshuizen, Els

2010-01-01

Bijker, M. M., Van der Klink, M. R., & Boshuizen, H. P. A. (2010, 25-27 August). Modelling self-efficacy, self-regulation, self-directed learning and career processes of adult professionals and relations with learning outcomes and labour market success. Paper presented at the 5th EARLI-SIG14

Suresh, Prof. Subra

Indian Academy of Sciences (India)

Date of birth: 30 May 1956. Address: President, Carnegie-Mellon University, 5000, Forbes Avenue, Pittsburgh, PA 15213, U.S.A.. Contact: Office: (_1-412) 268 2200. Email: president@cmu.edu. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus.

Science.gov (United States)

Piccinni, M-P; Lombardelli, L; Logiodice, F; Tesi, D; Kullolli, O; Biagiotti, R; Giudizi, Mg; Romagnani, S; Maggi, E; Ficarra, G

2014-03-01

The role of Th17 cells and associated cytokines was investigated in oral lichen planus. 14 consecutive patients with oral lichen planus were investigated. For biological studies, tissues were taken from reticular or erosive lesions and from normal oral mucosa (controls) of the same patient. mRNA expression for IL-17F, IL-17A, MCP-1, IL-13, IL-2, IL-10, IL-1β, RANTES, IL-4, IL-12B, IL-8, IFN-γ, TNF-α, IL-1α, IL-18, TGF-β1, IL-23R, IL-7, IL-15, IL-6, MIG, IP-10, LTB, VEGF, IL-5, IL-27, IL-23A, GAPDH, PPIB, Foxp3, GATA3, and RORC was measured using the QuantiGene 2.0. Results showed that Th17-type and Th0-type molecules' mRNAs, when compared with results obtained from tissue controls, were increased in biopsies of erosive lesions, whereas Th2-type molecules' mRNAs were increased in reticular lesions. When the CD4+ T-cell clones, derived from oral lichen planus tissues and tissue controls, were analyzed, a higher prevalence of Th17 (confirmed by an increased CD161 expression) and Th0 CD4+ T clones was found in erosive lesions, whereas a prevalence of Th2 clones was observed in reticular lesions. Our data suggest that Th17, Th0, and Th2 cells, respectively, may have a role in the pathogenesis of erosive and reticular oral lichen planus. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Comparisons between students' learning achievements of their conventional instruction and the science, technology and social conceptual instructional design on digestion system issue of secondary students at the 10th grade level

Science.gov (United States)

Wichalek, Supattra; Chayaburakul, Kanokporn; Santiboon, Toansakul

2018-01-01

The purposes of this action research study were 1) to develop learning activities according to the instructional designing model of science, technology, and social (STS) on Digestion Issue, 2) to compare students' learning achievements between their learning activities with the conventional instructional (CIM) and conceptual instructional designing methods of science, technology, and social (STS) on digestion system of secondary students at the 10th grade level with a sample size of 35 experimental student group of their STS learning method, and 91 controlling group in two classes in the first semester in academic year 2016. Using the 4-Instructional Innovative Lesson Plans, the Students' Learning Behaviour Observing Form, the Questionnaire on Teacher Behaviour Interaction (QTBI), the Researcher's Recording Form, the Learning Activity Form, and the Parallel Learning Achievement Test (LAT) were assessed. The results of this research have found that; the Index of Item Objective Congruence (IOC) value ranged from 0.67 to 1.00; the difficulty values were 0.47 and 0.79 for the CIM and STS methods, respectively, the discriminative validity for the LAT was ranged from 0.20 to 0.75. The reliability of the QTBI was 0.79. Students' responses of their learning achievements with the average means scores indicted of the normalized gain values of 0.79 for the STS group, and 0.50 and 0.36 for the CIM groups, respectively. Students' learning achievements of their post-test indicated that of a higher than pre-test, the pre-test and post-test assessments were also differentiated evidence at the 0.05 levels for the STS and CIM groups, significantly. The 22-students' learning outcomes from the STS group evidences at a high level, only of the 9-students' responses in a moderate level were developed of their learning achievements, responsibility.

Long-term gas and brine migration at the Waste Isolation Pilot Plant: Preliminary sensitivity analyses for post-closure 40 CFR 268 (RCRA), May 1992

International Nuclear Information System (INIS)

1992-12-01

This report describes preliminary probabilistic sensitivity analyses of long term gas and brine migration at the Waste Isolation Pilot Plant (WIPP). Because gas and brine are potential transport media for organic compounds and heavy metals, understanding two-phase flow in the repository and the surrounding Salado Formation is essential to evaluating long-term compliance with 40 CFR 268.6, which is the portion of the Land Disposal Restrictions of the Hazardous and Solid Waste Amendments to the Resource Conservation and Recovery Act that states the conditions for disposal of specified hazardous wastes. Calculations described here are designed to provide guidance to the WIPP Project by identifying important parameters and helping to recognize processes not yet modeled that may affect compliance. Based on these analyses, performance is sensitive to shaft-seal permeabilities, parameters affecting gas generation, and the conceptual model used for the disturbed rock zone surrounding the excavation. Brine migration is less likely to affect compliance with 40 CFR 268.6 than gas migration. However, results are preliminary, and additional iterations of uncertainty and sensitivity analyses will be required to provide the confidence needed for a defensible compliance evaluation. Specifically, subsequent analyses will explicitly include effects of salt creep and, when conceptual and computational models are available, pressure-dependent fracturing of anhydrite marker beds

DESIGN AND IMPLEMENTATION OF A PROPOSAL TO TEACH BASIC CONCEPTS IN PRIMARY PHYSICAL BASED ON THE THEORY OF MEANINGFUL LEARNING

Directory of Open Access Journals (Sweden)

Diana Paola Martínez-Salcedo

2015-01-01

Full Text Available This article discloses an experimental strategy that aims to contribute to science education in Colombia, through a proposal focusing on learning the concept of force. For this experimental teaching sequence for teaching and learning the concept of "Force" was developed from the perspective of meaningful learning of Ausubel; and applied to students from fifth grade of School Lucrecio Jaramillo Vélez, headquarters "Agrupación Colombia".  Initially an investigation of prior knowledge about the concept of force, according to the results was performed was developed and applied a proposal that included questionnaires, field work, observations in science classes, surveys, experiments, socialization of work laboratory and representations contained in the notebooks, the results of these activities were analyzed qualitatively, obtaining an evaluation and interpretation of the acquired learning observed in students an appropriation of the concept, possibly because it is a proposal of an experimental nature, focusing on the student, in which the exploration of phenomena by experimental means is favorable, the approach of hypotheses and troubleshooting, besides favoring an approach to enjoyment and joy by science.

TNF-α inhibitors reduce the pathological Th1 -Th17 /Th2 imbalance in cutaneous mesenchymal stem cells of psoriasis patients.

Science.gov (United States)

Campanati, Anna; Orciani, Monia; Lazzarini, Raffaella; Ganzetti, Giulia; Consales, Veronica; Sorgentoni, Giulia; Di Primio, Roberto; Offidani, Annamaria

2017-04-01

Psoriasis is a disease characterized by an imbalance between Th 1 and Th 17 and Th 2 inflammatory axes, in which cutaneous mesenchymal stem cells (MSCs) are early involved, as they show a greater relative expression of several genes encoding for Th 1 and Th 17 cytokines. Therapeutic implications of TNF-α inhibitors on differentiated skin cells have been largely described in psoriasis; however, their effects on MSCs derived from patients with psoriasis have been only partially described. The aim of this work was to evaluate the effect of TNF-α inhibitors on cytokine milieu expressed by MSCs isolated from the skin of patients with psoriasis. Resident MSCs from skin of patients with psoriasis and healthy subjects have been isolated, characterized and profiled by PCR and ELISA for the expression of 22 cytokines involved in Th 1 , Th 2 and Th 17 pathways, both before and after 12 weeks therapy with TNF-α inhibitors. The administration of TNF-α inhibitors for 12-weeks acts on MSCs as follows: it reduces the expression of several Th 1 -Th 17 cytokines whose levels are elevated at baseline (IL-6, IL-8, IL-12, IL-23A, IFN-γ, TNF-α, CCL2, CCL20, CXCL2, CXCL5, IL-17A, IL-17C, IL-17F, IL-21, G-CSF). Similarly, it enhances the expression of several Th 2 cytokines which are underexpressed at baseline (IL-2, IL-4, IL-5), reducing the expression of those overexpressed at baseline (TGF-β and IL-13). TNF-α inhibitors could contribute to reduce the pathological imbalance between the Th 1 -Th 17 vs Th 2 axis in MSCs of patients with psoriasis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Carcinoma papilífero da tireoide associado à tireoidite de Hashimoto Thyroid papillary carcinoma associated to Hashimoto's thyroiditis

Directory of Open Access Journals (Sweden)

Luiz Alexandre Albuquerque Freixo Campos

2012-12-01

Full Text Available Existe controvérsia na literatura quanto à associação entre Carcinoma Papilífero de Tireoide (CPT e Tireoidite de Hashimoto (TH e também quanto a qual seria a relação etiológica entre ambos. OBJETIVO: Determinar a proporção de casos de TH entre pacientes com CPT, correlacionando com aspectos histomorfológicos. MÉTODO: Foi realizado estudo retrospectivo de pacientes consecutivos submetidos à tireoidectomia parcial ou total por CPT, entre 2007 e 2009, totalizando de 41 casos. RESULTADOS: Em relação à associação de TH e CPT, foram encontrados 11 casos (26,8%, sendo todos do sexo feminino, porém, sem significância estatística. Nos casos em que havia CPT coexistente com TH a idade média foi de 44,9 anos e sem a associação, 49,1 anos. O tamanho médio dos tumores entre os sem TH foi 20,53mm e os com TH foi de 12,72 mm - p = 0,4. Em relação ao estadiamento anatomopatológico, as proporções entre os que apresentam TH e os que não apresentam foram mantidas em T1a, T1b e T3. Em T2, não houve casos de coexistência entre TH e CPT. CONCLUSÃO: Há uma proporção de 26,8% de pacientes que possuem associação entre TH e CPT, porém, sem diferenças em relação ao tamanho do tumor.There is controversy in the literature regarding the association between papillary thyroid carcinoma (PTC and Hashimoto's thyroiditis (HT and as to what would be the etiological relationship between them. OBJECTIVE: To establish the proportion of cases among patients with TH and CPT, correlating it with histomorphological aspects. METHOD: A retrospective study of patients undergoing partial or total thyroidectomy for PTC between 2007 and 2009, a total of 41 cases. RESULTS: Regarding the association of HT and CPT, we found 11 cases (26.8%, all females, but without statistical significance. The mean age was 44.9 years among the patients with coexistent TH and CPT, whereas it was 49.1 years without that association. The average size of tumors in those

Effect of practical training on the learning motivation profile of Japanese pharmacy students using structural equation modeling.

Science.gov (United States)

Yamamura, Shigeo; Takehira, Rieko

2017-01-01

To establish a model of Japanese pharmacy students' learning motivation profile and investigate the effects of pharmaceutical practical training programs on their learning motivation. The Science Motivation Questionnaire II was administered to pharmacy students in their 4th (before practical training), 5th (before practical training at clinical sites), and 6th (after all practical training) years of study at Josai International University in April, 2016. Factor analysis and multiple-group structural equation modeling were conducted for data analysis. A total of 165 students participated. The learning motivation profile was modeled with 4 factors (intrinsic, career, self-determination, and grade motivation), and the most effective learning motivation was grade motivation. In the multiple-group analysis, the fit of the model with the data was acceptable, and the estimated mean value of the factor of 'self-determination' in the learning motivation profile increased after the practical training programs (P= 0.048, Cohen's d = 0.43). Practical training programs in a 6-year course were effective for increasing learning motivation, based on 'self-determination' among Japanese pharmacy students. The results suggest that practical training programs are meaningful not only for providing clinical experience but also for raising learning motivation.

Indicators for successful learning in air traffic control training

NARCIS (Netherlands)

Van Meeuwen, Ludo; Brand-Gruwel, Saskia; Van Merriënboer, Jeroen; De Bock, Jeano; Kirschner, Paul A.

2011-01-01

Van Meeuwen, L. W., Brand-Gruwel, S., Van Merriënboer, J. J. G., De Bock, J. J. P. R., & Kirschner, P. A. (2010, August). Indicators for successful learning in air traffic control training. Paper presented at the 5th EARLI SIG 14 Learning and Professional Development Conference. Munich, Germany.

A Game for Learning History on Mobile Devices

Science.gov (United States)

Cruz, Sónia; Carvalho, Ana Amélia A.; Araújo, Inês

2017-01-01

This paper presents a game designed to support teaching and learning of Portuguese History to 6th grade students. Firstly, a state of the art of mobile game-based learning for History is presented. Then we describe shortly the research carried out which aimed at the analysis of the games most played by students, followed by the identification of…

Échecs thérapeutiques chez les enfants infectés par le VIH en suivi de routine dans un contexte à ressources limitées au Cameroun

Science.gov (United States)

Penda, Calixte Ida; Bebey, Francine Same; Mangamba, Danielle Kedy; Moukoko, Else Carole Eboumbou; Ngwa, Victoria; Makouet, Nicaise; Bissek, Anne-Cécile; Minkemdefo, Blaise Dupont; Tetanye, Ekoe; Ndombo, Paul Koki

2013-01-01

Introduction L'objectif de cette étude était de déterminer les facteurs associés aux échecs thérapeutiques chez les enfants infectés par le VIH à l'Hôpital Laquintinie de Douala. Méthodes Une étude transversale rétrospective a été menée sur une période de 5 mois en 2010, recrutant 222 enfants âgés de 1 à 18 ans et sous TARV depuis au moins 24 semaines. Les données sociodémographiques, cliniques, biologiques et de l'observance thérapeutique des patients ont été collectés à partir des dossiers des patients, et analysées avec le logiciel SPSS (version 16). Résultats 39 (17,6%) des enfants étaient en échec thérapeutique (délai moyen de survenue 26,8 mois) et 73,4% d'entre eux sont passés en seconde ligne. Les garçons avaient en moyenne un risque 5 fois plus élevé de faire un échec thérapeutique que les filles (OR=3,9; p=0,035). 94,4% des enfants suivis avaient un faible taux de CD4 à l'initiation (‘ 25%) associé au risque élevé d’échec thérapeutique (OR=5,2; p=0,007). Les enfants issus de famille monoparentale représentaient près de la moitié des cas d’échecs thérapeutiques. Sur 39 cas en échec thérapeutique, 41% des enfants étaient des orphelins. Parmi les enfants sous TARV, 46% prenaient leur trithérapie sous forme de médicaments séparés parmi lesquels 52,1% étaient en échec thérapeutique. Conclusion Les échecs thérapeutiques et le passage en seconde ligne dépendaient du contexte familial des enfants, de leur statut immunologique à l'initiation du traitement, de leur sexe et de la forme galénique du TARV. PMID:24171063

Impairment of the Intrinsic Capability of Th1 Polarization in Irradiated Mice: A Close Look at the Imbalanced Th1/Th2 Response after Irradiation.

Science.gov (United States)

Chen, Renxiang; Wang, Yi-Wen; Fornace, Albert J; Li, Heng-Hong

2016-12-01

Two major CD4 + T-helper (Th) lineages are Th1 and Th2, and well balanced Th1/Th2 responses are essential for immune function. In previously published studies, it was reported that radiation induces a Th1/Th2 immune imbalance toward a Th2-dominant direction, and this imbalance may contribute to postirradiation immune dysfunction. The polarization of Th cells is driven by the cytokine milieu and controlled by intracellular regulatory pathways that respond to cytokine signaling. It is widely accepted that radiation induces cytokine aberration, however, the precise alterations of cytokines in various tissue environments have been difficult to evaluate. In addition, the effects of radiation on the intrinsic functions of Th cells remain uncharacterized. Therefore, how radiation affects Th1/Th2 balance remains somewhat unclear. To address this, we investigated the changes in the polarization capability of Th cells by isolating them from mice previously exposed to radiation and assessing the cells in an established in vitro Th polarization system. Our novel results demonstrate that prior exposure to radiation led to the persistent aberration of the inherent capability of Th cells to differentiate into Th1 and Th2 lineages. The parallel changes in expression of Th1-specific master transcription factors and the key genes in metabolic reprograming indicated that radiation affects the core components in Th1 polarization. While Th1 differentiation was impaired after irradiation, little adverse effect was observed in Th2 differentiation; both of these findings contribute to the known phenotypes of Th1/Th2 imbalance caused by radiation.

Effectiveness of Web Quest in Enhancing 4th Grade Students' Spiritual Intelligence

Science.gov (United States)

Jwaifell, Mustafa; Al-Mouhtadi, Reham; Aldarabah, Intisar

2015-01-01

Spiritual intelligence has gained great interest from a good number of the researchers and scholars, while there is a lack of using new technologies such as WebQuest as an instructional tool; which is one of the e-learning applications in education in enhancing spiritual intelligence of 4th graders in Jordanian schools. This study aimed at…

Role of Th1 and Th2 cells in autoimmune demyelinating disease

NARCIS (Netherlands)

Nagelkerken, L.

1998-01-01

Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A maj or determinant in the development of Th1 and Th2 cells is the type of

Final Environmental Assessment for the First Air Force Air Operations Center, First Air Force Headquarters/Air Force Forces Center, and Highway 98 Overpass at Tyndall Air Force Base, Florida

Science.gov (United States)

2004-01-01

no comments regarding the Draft Environmental Assessment for the First Air Force Operations Center, First Air Force Headquarters/Air Force Forces...COUNCIL ] No Comment BAY - BAY COUNTY No Final Comments Received ENVIRONMENTAL POLICY UNIT - OFFICE OF POLICY AND BUDGET, ENVIRONMENTAL POLICY UNIT NO ...CONSERVATION COMMISSION [ NO COMMENT BY BRIAN BARNETT ON 4/12/04. [STATE - FLORIDA DEPARTMENT OF STATE [ No Comment [TRANSPORTATION - FLORIDA DEPARTMENT

16th UK Workshop on Computational Intelligence

CERN Document Server

Gegov, Alexander; Jayne, Chrisina; Shen, Qiang

2017-01-01

The book is a timely report on advanced methods and applications of computational intelligence systems. It covers a long list of interconnected research areas, such as fuzzy systems, neural networks, evolutionary computation, evolving systems and machine learning. The individual chapters are based on peer-reviewed contributions presented at the 16th Annual UK Workshop on Computational Intelligence, held on September 7-9, 2016, in Lancaster, UK. The book puts a special emphasis on novels methods and reports on their use in a wide range of applications areas, thus providing both academics and professionals with a comprehensive and timely overview of new trends in computational intelligence.

Chilean 12th graders’ Attitudes towards English as a Foreign Language

Directory of Open Access Journals (Sweden)

Eric Gómez Burgos

2015-10-01

Full Text Available This article aims to provide the results of a research focusing on 12th graders’ attitudes towards English as a Foreign Language in two secondary schools in Puerto Montt, Chile. Attitude towards a language has been considered as an important factor that influences the process of learning a foreign language (Shams, 2008; for this reason, it is fundamental to identify students’ attitudes since positive attitudes towards English allow the students to have favourable orientation towards learning it (Karahan, 2007. Under this premise, this study corresponds to a case study that includes a quantitative method of data analysis. A survey of five dimensions was conducted amongst 154 students in order to measure their attitudes towards the target language. The results show that their attitudes towards English as a foreign language are favourable; however, the dimensions related to learning English, and English as a subject at school obtained unfavourable attitudes.

The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation

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Shang Li

2018-01-01

Full Text Available Purpose. CD4+LAP+ T cells are newly discovered regulatory T cells (Tregs. The aim of this study is to investigate the balance of Th1/Th2 and LAP+Tregs/Th17 in mice after allogeneic corneal transplantation. Methods. A total of 65 mice received orthotopic penetrating transplantation. According to the survival scores of the grafts, the mice were divided into the rejection group and the survival group 3 weeks after transplantation. Th1, Th2, Th17, and regulatory T cells in the ipsilateral drainage lymph nodes and spleens were measured with flow cytometry. The related cytokines in aqueous humor were also analyzed. Results. The frequencies of Foxp3+Tregs, GARP+Tregs, and LAP+Tregs in the survival group were significantly higher than those in the rejection group. And the expression trend of CD4+LAP+ T cells and CD4+GARP+ T cells was consistent. The level of IFN-γ, TNF, IL-6, and IL-17A markedly increased in aqueous humor during corneal allograft rejection. The ratio of Th1/Th2 and Th17/LAP+Tregs significantly increased in the rejection group at the 3rd week after corneal transplantation. Conclusion. LAP+Tregs might be regarded as substitute for Foxp3+Tregs. The balance of Th1/Th2 and LAP+Tregs/Th17 is crucial for corneal allograft survival.

On Learning Maps

Science.gov (United States)

1975-09-01

Director, Office of Manpower Utilizatic Headquarters, Marine Corps (Code MPU ) MCB (Building 2009) Quantico, VA 22134 1 Dr. A.L. Slafkosky...National Defence HQ Ottawa, Canada K1A OK 2 1 Dr. Alma E. Lantz University of Denver Denver Research Institute Industrial Economics Division

spv locus aggravates Salmonella infection of zebrafish adult by inducing Th1/Th2 shift to Th2 polarization.

Science.gov (United States)

Wu, Shu-Yan; Wang, Li-Dan; Xu, Guang-Mei; Yang, Si-di; Deng, Qi-Feng; Li, Yuan-Yuan; Huang, Rui

2017-08-01

Salmonella enterica serovar typhimurium (S. typhimurium) are facultative intracellular enteric pathogens causing disease with a broad range of hosts. It was known that Th1-type cytokines such as IFN-γ, IL-12, and TNF-α etc. could induce protective immunity against intracellular pathogens, while Th2-type cytokines such as IL-4, IL-10, and IL-13 etc. are proved to help pathogens survive inside hosts and cause severe infection. One of the critical virulence factor attributes to the pathogenesis of S. typhimurium is Salmonella plasmid virulence genes (spv). Until now, the interaction between spv locus and the predictable generation of Th1 or Th2 immune responses to Salmonella has not been identified. In this study, zebrafish adults were employed to explore the effect of spv locus on Salmonella pathogenesis as well as host adaptive immune responses especially shift of Th1/Th2 balance. The pathological changes of intestines and livers in zebrafish were observed by hematoxylin-eosin (HE) staining and electron microscopy. Levels of the transcription factors of Th1 (Tbx21) and Th2 (GATA3) were measured by real-time quantitative PCR (RT-qPCR). Expression of cytokines were determined by using RT-qPCR and ELISA, respectively. Results showed that spv operon aggravates damage of zebrafish. Furthermore, it demonstrated that spv locus could inhibit the transcription of tbx21 gene and suppress the expression of cytokines IFN-γ, IL-12 and TNF-α. On the contrary, the transcription of gata3 gene could be promoted and the expression of cytokines IL-4, IL-10 and IL-13 were enhanced by spv locus. Taken together, our data revealed that spv locus could aggravate Salmonella infection of zebrafish adult by inducing an imbalance of Th1/Th2 immune response and resulting in a detrimental Th2 bias of host. Copyright © 2017. Published by Elsevier Ltd.

Let's Face(book) It: Analyzing Interactions in Social Network Groups for Chemistry Learning

Science.gov (United States)

Rap, Shelley; Blonder, Ron

2016-02-01

We examined how social network (SN) groups contribute to the learning of chemistry. The main goal was to determine whether chemistry learning could occur in the group discourse. The emphasis was on groups of students in the 11th and 12th grades who learn chemistry in preparation for their final external examination. A total of 1118 discourse events were tallied in the different groups. We analyzed the different events that were found in chemistry learning Facebook groups (CLFGs). The analysis revealed that seven types of interactions were observed in the CLFGs: The most common interaction (47 %) dealt with organizing learning (e.g., announcements regarding homework, the location of the next class); learning interactions were observed in 22 % of the posts, and links to learning materials and social interactions constituted about 20 % each. The learning events that were ascertained underwent a deeper examination and three different types of chemistry learning interactions were identified. This examination was based on the theoretical framework of the commognitive approach to learning (Sfard in Thinking as communicating. Cambridge University Press, Cambridge, 2008), which will be explained. The identified learning interactions that were observed in the Facebook groups illustrate the potential of SNs to serve as an additional tool for teachers to advance their students' learning of chemistry.

Thermal expansion studies on Th(MoO4)2, Na2Th(MoO4)3 and Na4Th(MoO4)4

International Nuclear Information System (INIS)

Keskar, Meera; Krishnan, K.; Dahale, N.D.

2008-01-01

Thermal expansion behavior of Th(MoO 4 ) 2 , Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 was studied under vacuum in the temperature range of 298-1123 K by high temperature X-ray diffractometer. Th(MoO 4 ) 2 was synthesized by reacting ThO 2 with 2 mol of MoO 3 , at 1073 K in air and Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were prepared by reacting Th(MoO 4 ) 2 with 1 and 2 mol of Na 2 MoO 4 , respectively at 873 K in air. The XRD data of Th(MoO 4 ) 2 was indexed on orthorhombic system where as XRD data of Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were indexed on tetragonal system. The lattice parameters and cell volume of all the three compounds, fit into polynomial expression with respect to temperature, showed positive thermal expansion (PTE) up to 1123 K. The average value of thermal expansion coefficients for Th(MoO 4 ) 2 , Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were determined from the high temperature data

The contribution of nuclear energy co-operation to a new global age, OECD Headquarters, Paris, 30 September 1998

International Nuclear Information System (INIS)

ElBaradei, M.

1998-01-01

The document reproduces the text of the conference given by the Director General of the IAEA at the Special Session to mark the Fortieth Anniversary of the OECD Nuclear Energy Agency (NEA), held at the OECD Headquarters in Paris, on 30 September 1998. The conference emphasizes the role of the IAEA in enlarging the contribution of nuclear energy for peace and development, and ensuring that atomic energy is used at a high level of security and exclusively for peaceful purposes. The Agency was never intended to 'promote' nuclear energy in any commercial sense. Its role is to be an objective institution that serves as a centre for international norm development, standard setting, independent analysis, expert advice, technology transfer, and impartial oversight and verification. From this perspective, the Director General offers some views on why the international nuclear co-operation, complemented by regional and national activities, is an indispensable part of way forward, highlighting the following areas: energy, safety, verification, and technology transfer

The Arab Spring and civil-military relations

African Journals Online (AJOL)

abel

power interplay between the civil elites and the military elites using the term 'civil- military relations' ..... the American military, whose 5th Fleet is headquartered in Bahrain. The advice was that the ..... Embassy Madrid. 23 Danopoulos, C (ed).

Computer assisted instruction on "learning nutrition flags for deaf 5th grade and 6th grad students": effectiveness of instruction.

Science.gov (United States)

Srisorachatr, Suwat; Huadong, Yotsinee; Hudthagosol, Chatrapa; Danthanavanich, Suksiri

2013-12-01

Deaf students are of a number of under privilege group for whom there are limited resources for their use, related to health including nutrition. The purpose of this research was to create computer-assisted instruction for "nutrition flags" for 5 and 6th grade students. The content of nutrition included the concept of a healthy balance diets and portion sizes of each food group. The content and pictures for computer-assisted instruction came from existing curriculum, and focused on nutritional content. The contents in this instruction were divided into three units according to students' learning capacity. The story boards were developed by staff including nutritionists, Thai sign language interpreters, and deaf students. Then, the contents and nutrition vocabulary were translated into Thai sign language. After recording the sign language on video, this material was merged with the contents and converted into a computer program. The computer assisted instruction was tested with students from Nakon Pathom School for the Deaf The first trial was conducted with three students, the second with five students, and the third with 15 students during the academic year 2009. The computer- assisted instruction was revised until it met the standard criteria of 80/80. Effectiveness testing was carried out with 36 students for five consecutive days. On the first day, the pre-test was completed, and on days 2-4, the students performed self-study and completed the exercises for units 1-3, with 50 minutes spent on each unit. The post-test was completed on the last day. The study was conducted during the 2010 academic year Data analysis was performed using the t-test. The results showed an effectiveness of 81.85/82.22, which was higher than the standard criteria of 80/80. The post-test average score was higher than the pre-test average score with a statistical significance level at p < 0.0001. Suggestions for instruction for the deaf are that the length of the instruction in each

An assessment of student experiences and learning based on a novel undergraduate e-learning resource.

Science.gov (United States)

Mehta, S; Clarke, F; Fleming, P S

2016-08-12

Purpose/objectives The aims of this study were to describe the development of a novel e-learning resource and to assess its impact on student learning experiences and orthodontic knowledge.Methods Thirty-two 4th year dental undergraduate students at Queen Mary University of London were randomly allocated to receive electronic access to e-learning material covering various undergraduate orthodontic topics over a 6-week period. Thirty-one control students were not given access during the study period. All students were asked to complete electronic quizzes both before (T0) and after (T1) the study period and a general questionnaire concerning familiarity with e-learning. The test group also completed a user satisfaction questionnaire at T1. Two focus groups were also undertaken to explore learners' experiences and suggestions in relation to the resource.Results The mean quiz result improved by 3.9% and 4.5% in the control and test groups, respectively. An independent t-test, however, demonstrated a lack of statistical significance in knowledge gain between control and test groups (P = 0.941). The qualitative feedback indicated that students believed that use of the resource enhanced knowledge and basic understanding with students expressing a wish to ingrain similar resources in other areas of undergraduate teaching.Conclusions Use of the novel orthodontic e-resource by 4th year undergraduate students over a 6-week period did not result in a significant improvement in subject knowledge. However, the e-learning has proven popular among undergraduates and the resources will continue to be refined.

Academic stress-induced changes in Th1- and Th2-cytokine response

Directory of Open Access Journals (Sweden)

Areej M. Assaf

2017-12-01

Full Text Available Psychological stress stimulates physiological responses releasing catecholamines and corticoids, which act via corresponding receptors on immune cells, producing a shift in the cytokine balance. These responses are variable depending on the nature of stressors. The effect of the academic stress on the production of the Th1-cytokines (TNF-α, IFN-γ, IL-1β, IL-2, IL-6 and IL-8 and Th2-cytokines (IL-1ra, IL-4, IL-5 and IL-10 on 35 medical/health sciences students after completing their questionnaires was investigated. Blood samples were taken at three stages; baseline stage at the beginning, midterm and final academic examination stages. Plasma cortisol and cytokines were measured during the three stages. The last two stages were compared with the baseline non-stress period. Results of the stress induced during the final examination stage were the highest with a significant increase in cortisol release, IL-4, IL-5 and IL-1ra release with a shift in Th1:Th2 cytokines balance towards Th2. Whereby, the midterm stage did not show significant reduction in Th1-cytokines except for TNF-α, with an increase in IFN-γ level that was reduced in the third stage. Th2 cytokine, IL-1ra, had positive correlations with Th1 cytokines; IL-2 and IFN-γ in the second stage and IL-6 cytokine in the third stage. Cortisol was positively correlated with IL-8 in the last stage and heart rates had negative correlation with IL-10 in the first and last stages. Findings of this study indicate that exam stress down-regulates Th1 with a selective up-regulation of Th2-cytokines. In conclusion, Cortisol might have a role in suppressing the release of Th1- mediated cellular immune response which could increase the vulnerability among the students to infectious diseases.

Academic stress-induced changes in Th1- and Th2-cytokine response.

Science.gov (United States)

Assaf, Areej M; Al-Abbassi, Reem; Al-Binni, Maysaa

2017-12-01

Psychological stress stimulates physiological responses releasing catecholamines and corticoids, which act via corresponding receptors on immune cells, producing a shift in the cytokine balance. These responses are variable depending on the nature of stressors. The effect of the academic stress on the production of the Th1-cytokines (TNF-α, IFN-γ, IL-1β, IL-2, IL-6 and IL-8) and Th2-cytokines (IL-1ra, IL-4, IL-5 and IL-10) on 35 medical/health sciences students after completing their questionnaires was investigated. Blood samples were taken at three stages; baseline stage at the beginning, midterm and final academic examination stages. Plasma cortisol and cytokines were measured during the three stages. The last two stages were compared with the baseline non-stress period. Results of the stress induced during the final examination stage were the highest with a significant increase in cortisol release, IL-4, IL-5 and IL-1ra release with a shift in Th1:Th2 cytokines balance towards Th2. Whereby, the midterm stage did not show significant reduction in Th1-cytokines except for TNF-α, with an increase in IFN-γ level that was reduced in the third stage. Th2 cytokine, IL-1ra, had positive correlations with Th1 cytokines; IL-2 and IFN-γ in the second stage and IL-6 cytokine in the third stage. Cortisol was positively correlated with IL-8 in the last stage and heart rates had negative correlation with IL-10 in the first and last stages. Findings of this study indicate that exam stress down-regulates Th1 with a selective up-regulation of Th2-cytokines. In conclusion, Cortisol might have a role in suppressing the release of Th1- mediated cellular immune response which could increase the vulnerability among the students to infectious diseases.

Development and application of the practice tool to deal with severe accident

International Nuclear Information System (INIS)

Kawasaki, Ikuo; Yoshida, Yoshitaka; Iwasaki, Yoshito

2014-01-01

We developed the practice tool to simulate communications between operators at a nuclear power station and persons at the headquarters at the time of severe accident (SA). The tool was developed from considering the lessons learned in dealing with the accident at the Tokyo Electric Power Company Fukushima Daiichi Nuclear Power Station, especially related to making appropriate responses to events. The tool allows users at headquarters to learn about the constitution of a specific plant and to make a reply and state a judgment based on knowledge about SA. The situations used for the practice tool were made using SPDS data from past disaster prevention drills. In a test, SA education of headquarters workers was carried out using this practice tool, and we confirmed that users were able to make the right phenomenon judgment and communicate it effectively based on the knowledge given by this practice tool. (author)

Individual values, learning routines and academic procrastination.

Science.gov (United States)

Dietz, Franziska; Hofer, Manfred; Fries, Stefan

2007-12-01

Academic procrastination, the tendency to postpone learning activities, is regarded as a consequence of postmodern values that are prominent in post-industrialized societies. When students strive for leisure goals and have no structured routines for academic tasks, delaying strenuous learning activities becomes probable. The model tested in this study posits that postmodern value orientations are positively related to procrastination and to a lack of daily routines concerning the performance of academic activities. In contrast, modern values are negatively related to procrastination and positively to learning routines. Academic procrastination, in-turn, should be associated with the tendency to prefer leisure activities to schoolwork in case of conflicts between these two life domains. Seven hundred and four students from 6th and 8th grade with a mean age of 13.5 years participated in the study. The sample included students from all tracks of the German educational system. Students completed a questionnaire containing two value prototypes as well as scales on learning routines and procrastination. Decisions in motivational conflicts were measured using two vignettes. Results from structural equation modelling supported the proposed model for the whole sample as well as for each school track. A planned course of the day can prevent procrastination and foster decisions for academic tasks in case of conflicts. Students' learning takes place within a societal context and reflects the values held in the respective culture.

4th International conference on Knowledge Discovery and Data Mining

CERN Document Server

Knowledge Discovery and Data Mining

2012-01-01

The volume includes a set of selected papers extended and revised from the 4th International conference on Knowledge Discovery and Data Mining, March 1-2, 2011, Macau, Chin.   This Volume is to provide a forum for researchers, educators, engineers, and government officials involved in the general areas of knowledge discovery and data mining and learning to disseminate their latest research results and exchange views on the future research directions of these fields. 108 high-quality papers are included in the volume.

Attending to Structural Programming Features Predicts Differences in Learning and Motivation

Science.gov (United States)

Witherspoon, Eben B.; Schunn, Christian D.; Higashi, Ross M.; Shoop, Robin

2018-01-01

Educational robotics programs offer an engaging opportunity to potentially teach core computer science concepts and practices in K-12 classrooms. Here, we test the effects of units with different programming content within a virtual robotics context on both learning gains and motivational changes in middle school (6th-8th grade) robotics…

Use of Circadian Lighting System to improve night shift alertness and performance of NRC Headquarters Operations Officers

International Nuclear Information System (INIS)

Baker, T.L.; Morisseau, D.; Murphy, N.M.

1995-01-01

The Nuclear Regulatory Commission's (NRC) Headquarters Operations Officers (HOOs) receive and respond to events reported in the nuclear industry on a 24-hour basis. The HOOs have reported reduced alertness on the night shift, leading to a potential deterioration in their on-shift cognitive performance during the early morning hours. For some HOOs, maladaptation to the night shift was also reported to be the principal cause of: (a) reduced alertness during the commute to and from work, (b) poor sleep quality, and (c) personal lifestyle problems. ShiftWork Systems, Inc. (SWS) designed and installed a Circadian Lighting System (CLS) at both the Bethesda and Rockville HOO stations with the goal of facilitating the HOOs physiological adjustment to their night shift schedules. The data indicate the following findings: less subjective fatigue on night shifts; improved night shift alertness and mental performance; higher HOO confidence in their ability to assess event reports; longer, deeper and more restorative day sleep after night duty shifts; swifter adaptation to night work; and a safer commute, particularly for those with extensive drives

Use of Circadian Lighting System to improve night shift alertness and performance of NRC Headquarters Operations Officers

Energy Technology Data Exchange (ETDEWEB)

Baker, T.L.; Morisseau, D.; Murphy, N.M. [ShiftWork Systems, Cambridge, MA (United States)] [and others

1995-04-01

The Nuclear Regulatory Commission`s (NRC) Headquarters Operations Officers (HOOs) receive and respond to events reported in the nuclear industry on a 24-hour basis. The HOOs have reported reduced alertness on the night shift, leading to a potential deterioration in their on-shift cognitive performance during the early morning hours. For some HOOs, maladaptation to the night shift was also reported to be the principal cause of: (a) reduced alertness during the commute to and from work, (b) poor sleep quality, and (c) personal lifestyle problems. ShiftWork Systems, Inc. (SWS) designed and installed a Circadian Lighting System (CLS) at both the Bethesda and Rockville HOO stations with the goal of facilitating the HOOs physiological adjustment to their night shift schedules. The data indicate the following findings: less subjective fatigue on night shifts; improved night shift alertness and mental performance; higher HOO confidence in their ability to assess event reports; longer, deeper and more restorative day sleep after night duty shifts; swifter adaptation to night work; and a safer commute, particularly for those with extensive drives.

Seven scientists advise

International Nuclear Information System (INIS)

1959-01-01

The Scientific Advisory Committee of the International Atomic Energy Agency met for the first time at the headquarters of the United Nations on the 14th and 15th of November. The Committee was appointed the 4th of November by the IAEA Board of Governors which approved the nominations submitted by the Director General. The members of the Committee are: Homi Jehangir Bhabha, Sir John Cockcroft, Vasilij S. Emelyanov, Bertrand Goldschmidt, Bernhard Gross, Wilfrid Bennet Lewis and Isidor I. Rabi

Asymmetrically deformed third minimum in the 231Th and 233Th fission barriers

International Nuclear Information System (INIS)

Blons, J.; Mazur, C.; Paya, D.; Ribrag, M.; Weigmann, H.

1981-01-01

Neutron induced fission cross-sections of 230 Th and 232 Th have been measured up to 5 MeV. The electron linear accelerator (GELINA) has been used as a neutron time of flight spectrometer with a nominal resolution of 84 psec/m for 230 Th(n,f) and 42 psec/m for 232 Th(n,f) reaction. The fission fragment detector was a 6 cell gas scintillator filled with xenon. The existence of fine structure peaks, a few keV wide, in both the 230 Th(n,f) and 232 Th(n,f) cross sections, is definitively confirmed. The analysis of the two vibrational resonances located respectively at 720 keV for 230 Th(the figure) and 1.6 MeV for 232 Th, shows clearly that these peaks can be interpreted, in terms of two rotational bands with opposite parities. This parity degeneracy is a consequence of the asymmetric, pear-like deformation of the excited nucleus [ru

4th Workshop on Combinations of Intelligent Methods and Applications

CERN Document Server

Palade, Vasile; Prentzas, Jim

2016-01-01

This volume includes extended and revised versions of the papers presented at the 4th Workshop on “Combinations of Intelligent Methods and Applications” (CIMA 2014) which was intended to become a forum for exchanging experience and ideas among researchers and practitioners dealing with combinations of different intelligent methods in Artificial Intelligence. The aim is to create integrated or hybrid methods that benefit from each of their components. Some of the existing presented efforts combine soft computing methods (fuzzy logic, neural networks and genetic algorithms). Another stream of efforts integrates case-based reasoning or machine learning with soft-computing methods. Some of the combinations have been more widely explored, like neuro-symbolic methods, neuro-fuzzy methods and methods combining rule-based and case-based reasoning. CIMA 2014 was held in conjunction with the 26th IEEE International Conference on Tools with Artificial Intelligence (ICTAI 2014). .

Effect of practical training on the learning motivation profile of Japanese pharmacy students using structural equation modeling

Directory of Open Access Journals (Sweden)

Shigeo Yamamura

2017-02-01

Full Text Available Purpose To establish a model of Japanese pharmacy students’ learning motivation profile and investigate the effects of pharmaceutical practical training programs on their learning motivation. Methods The Science Motivation Questionnaire II was administered to pharmacy students in their 4th (before practical training, 5th (before practical training at clinical sites, and 6th (after all practical training years of study at Josai International University in April, 2016. Factor analysis and multiple-group structural equation modeling were conducted for data analysis. Results A total of 165 students participated. The learning motivation profile was modeled with 4 factors (intrinsic, career, self-determination, and grade motivation, and the most effective learning motivation was grade motivation. In the multiple-group analysis, the fit of the model with the data was acceptable, and the estimated mean value of the factor of ‘self-determination’ in the learning motivation profile increased after the practical training programs (P= 0.048, Cohen’s d= 0.43. Conclusion Practical training programs in a 6-year course were effective for increasing learning motivation, based on ‘self-determination’ among Japanese pharmacy students. The results suggest that practical training programs are meaningful not only for providing clinical experience but also for raising learning motivation.

E-Learning: Its Implementation in Higher Institutions in Nigeria ...

African Journals Online (AJOL)

Advances in computer, communication and network technology have led to the evolution of new ways of learning generally grouped as, and termed e-learning. It is a name that came into existence not more than a decade ago though it was being implemented since the second half of the 20th century in its various sub forms.

Integrating a WebQuest in the Primary School Curriculum Using Anchored Instruction: Effect on Learning Outcomes

NARCIS (Netherlands)

Segers, P.C.J.; Droop, W.; Verhoeven, L.T.W.

2010-01-01

Based on a literature review, a means for integrating WebQuests in day-to-day school activities is introduced using principles of Anchored Instruction. Following these ideas in an effect study, including 109 children in 4th, 5th and 6th grade, significant learning gains were found, with a large

Boundary crossing and learning identities – digital storytelling in primary schools

Directory of Open Access Journals (Sweden)

Anne Mette Bjørgen

2010-11-01

Full Text Available This article contributes to academic discussions on how digital storytelling in an educational setting may have potential to build and develop learning identities, agency and digital competences. With a socio-cultural framework on learning and identity as a point of departure, the article sets out to study these issues approached as boundary crossing between the intersecting contexts of leisure time and school. The analysis draws on three examples of digital storytelling among 5th - 7th graders in three Norwegian primary school classes. My findings suggest that digital storytelling might represent a boundary crossing enabling pupils to adopt new roles as producers of creative content, as mentors or guides, to explore new technology and software in a context different from that of outside school and to learn and develop competences related to production processes and multimodal resources. I argue that digital storytelling has a potential to contribute to learning, learning identity and agency, provided it is based on a more fully developed pedagogical strategy of carefully linking school and leisure time.

Circulating endothelial progenitor cells, Th1/Th2/Th17-related cytokines, and endothelial dysfunction in resistant hypertension.

Science.gov (United States)

Magen, Eli; Feldman, Arie; Cohen, Ziona; Alon, Dora Ben; Minz, Evegeny; Chernyavsky, Alexey; Linov, Lina; Mishal, Joseph; Schlezinger, Menacham; Sthoeger, Zev

2010-02-01

A possible link between chronic vascular inflammation and arterial hypertension is now an object of intensive studies. To compare Th1/Th2/Th17 cells-related cytokines, circulating endothelial progenitor cells (EPC), and endothelial function in subjects with resistant arterial hypertension (RAH) and controlled arterial hypertension (CAH). Blood pressure was measured by electronic sphygmomanometer. EPC were identified as CD34+/CD133+/kinase insert domain receptor (KDR)+ cells by flow cytometry. Th1/Th2/Th17 cells-related cytokines were identified using the Human Th1/Th2/Th17 Cytokines MultiAnalyte ELISArray Kit. Endothelium-dependent (FMD) vasodilatation of brachial artery was measured by Doppler ultrasound scanning. RAH group (n = 20) and CAH group (n = 20) and 17 healthy individuals (control group) were recruited. In the RAH group, lower blood levels of EPC number (42.4 +/- 16.7 cells/mL) and EPC% (0.19 +/- 0.08%) were observed than in the CAH group (93.1 +/- 88.7 cells/mL; P = 0.017; 0.27 +/- 0.17; P = 0.036) and control group (68.5 +/- 63.6 cells/mL; P < 0.001; 0.28 +/- 0.17%; P = 0.003), respectively. Plasma transforming growth factor-beta1 levels were significantly higher in the RAH group (1767 +/- 364 pg/mL) than in the CAH group (1292 +/- 349; P < 0.001) and in control group (1203 +/- 419 pg/mL; P < 0.001). In the RAH group, statistically significant negative correlation was observed between systolic blood pressure and EPC% (r = -0.72, P < 0.01). FMD in the RAH group was significantly lower (5.5 +/- 0.8%) than in the CAH group (9.2 +/- 1.4; P < 0.001) and in healthy controls (10.1 +/- 1.1%; P < 0.001). RAH is characterized by reduced circulating EPC, substantial endothelial dysfunction, and increased plasma transforming growth factor-beta1 levels.

Inquiry learning for gender equity using History of Science in Life and Earth Sciences’ learning environments

OpenAIRE

C. Sousa

2016-01-01

[EN] The main objective of the present work is the selection and integration of objectives and methods of education for gender equity within the Life and Earth Sciences’ learning environments in the current portuguese frameworks of middle and high school. My proposal combines inquiry learning-teaching methods with the aim of promoting gender equity, mainly focusing in relevant 20th century women-scientists with a huge contribute to the History of Science.The hands-on and minds-on activities p...

Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines.

Science.gov (United States)

Vuong, H E; Pérez de Sevilla Müller, L; Hardi, C N; McMahon, D G; Brecha, N C

2015-10-29

Transgenic mouse lines are essential tools for understanding the connectivity, physiology and function of neuronal circuits, including those in the retina. This report compares transgene expression in the retina of a tyrosine hydroxylase (TH)-red fluorescent protein (RFP) mouse line with three catecholamine-related Cre recombinase mouse lines [TH-bacterial artificial chromosome (BAC)-, TH-, and dopamine transporter (DAT)-Cre] that were crossed with a ROSA26-tdTomato reporter line. Retinas were evaluated and immunostained with commonly used antibodies including those directed to TH, GABA and glycine to characterize the RFP or tdTomato fluorescent-labeled amacrine cells, and an antibody directed to RNA-binding protein with multiple splicing to identify ganglion cells. In TH-RFP retinas, types 1 and 2 dopamine (DA) amacrine cells were identified by their characteristic cellular morphology and type 1 DA cells by their expression of TH immunoreactivity. In the TH-BAC-, TH-, and DAT-tdTomato retinas, less than 1%, ∼ 6%, and 0%, respectively, of the fluorescent cells were the expected type 1 DA amacrine cells. Instead, in the TH-BAC-tdTomato retinas, fluorescently labeled AII amacrine cells were predominant, with some medium diameter ganglion cells. In TH-tdTomato retinas, fluorescence was in multiple neurochemical amacrine cell types, including four types of polyaxonal amacrine cells. In DAT-tdTomato retinas, fluorescence was in GABA immunoreactive amacrine cells, including two types of bistratified and two types of monostratified amacrine cells. Although each of the Cre lines was generated with the intent to specifically label DA cells, our findings show a cellular diversity in Cre expression in the adult retina and indicate the importance of careful characterization of transgene labeling patterns. These mouse lines with their distinctive cellular labeling patterns will be useful tools for future studies of retinal function and visual processing. Published by Elsevier

Oxidative stress modulates the cytokine response of differentiated Th17 and Th1 cells.

Science.gov (United States)

Abimannan, Thiruvaimozhi; Peroumal, Doureradjou; Parida, Jyoti R; Barik, Prakash K; Padhan, Prasanta; Devadas, Satish

2016-10-01

Reactive oxygen species (ROS) signaling is critical in T helper (Th) cell differentiation; however its role in differentiated Th cell functions is unclear. In this study, we investigated the role of oxidative stress on the effector functions of in vitro differentiated mouse Th17 and Th1 cells or CD4 + T cells from patients with Rheumatoid Arthritis using pro-oxidants plumbagin (PB) and hydrogen peroxide. We found that in mouse Th cells, non-toxic concentration of pro-oxidants inhibited reactivation induced expression of IL-17A in Th17 and IFN-γ in Th1 cells by reducing the expression of their respective TFs, RORγt and T-bet. Interestingly, in both the subsets, PB increased the expression of IL-4 by enhancing reactivation induced ERK1/2 phosphorylation. We further investigated the cytokine modulatory effect of PB on CD4 + T cells isolated from PBMCs of patients with Rheumatoid Arthritis, a well-known Th17 and or Th1 mediated disease. In human CD4 + T cells from Rheumatoid Arthritis patients, PB reduced the frequencies of IL-17A + (Th17), IFN - γ + (Th1) and IL-17A + /IFN - γ + (Th17/1) cells and also inhibited the production of pro-inflammatory cytokines TNF-α and IL-6. N-Acetyl Cysteine (NAC) an antioxidant completely reversed PB mediated cytokine modulatory effects in both mouse and human cells indicating a direct role for ROS. Together our data suggest that oxidative microenvironment can alter cytokine response of terminally differentiated cells and thus altering intracellular ROS could be a potential way to target Th17 and Th1 cells in autoimmune disorders. Copyright © 2016. Published by Elsevier Inc.

Positioning Learning Design: Learner Experience and the challenges of transforming teaching practice

NARCIS (Netherlands)

Johnson, Mark; Griffiths, Dai; Hanslot, Zubair

2010-01-01

Johnson, M., Griffiths, D., & Hanslot, Z. (2010). Positioning Learning Design: Learner Experience and the challenges of transforming teaching practice. In D. Griffiths, & R. Koper (Eds.), Rethinking Learning and Employment at a Time of Economic Uncertainty. Proceedings of the 6th TENCompetence Open

Facilitating Work Based Learning Projects: A Business Process Oriented Knowledge Management Approach

NARCIS (Netherlands)

Miao, Yongwu; Sloep, Peter; Koper, Rob

2009-01-01

Miao, Y., Sloep, P. B., & Koper, R. (2010). Facilitating Work Based Learning Projects: A Business Process Oriented Knowledge Management Approach. In D. Griffiths & R. Koper (Eds.), Rethinking Learning and Employment at a Time of Economic Uncertainty. Proceedings of the 6th TENCompetence Open

A design-based approach with vocational teachers to promote self-regulated learning

NARCIS (Netherlands)

Jossberger, Helen; Brand-Gruwel, Saskia; Van de Wiel, Margje; Boshuizen, Els

2011-01-01

Jossberger, H., Brand-Gruwel, S., Van de Wiel, M., & Boshuizen, H. P. A. (2011, August). A design-based approach with vocational teachers to promote self-regulated learning. Presentation at the 14th European Conference for Research on Learning and Instruction (EARLI), Exeter, England.

MoViE: Experiences and attitudes—Learning with a mobile social video application

Directory of Open Access Journals (Sweden)

Pauliina Tuomi

2010-10-01

Full Text Available Digital media is increasingly finding its way into the discussions of the classroom. Particularly interest is placed on mobile learning—the learning and teaching practices done with or via different mobile devices. Learning with the help of mobile devices is increasingly common and it is considered to be one of the 21st century skills children should adapt already in early stages in schools. The article presents both qualitative and quantitative study on mobile social video application, MoViE, as a part of teaching in biology and geography in 8th and 9th grades. The multidisciplinary data was processed to answer the following question: How did the use of mobile videos promote learning? The actual research question is however twofold: On one hand, it studies the use of mobile videos in mobile learning. On the other hand, it sets out to investigate the implementation of mobile video sharing as a part of the teaching and learning activities.

Design Fixation and Cooperative Learning in Elementary Engineering Design Project: A Case Study

Directory of Open Access Journals (Sweden)

Yi Luo

2015-09-01

Full Text Available This paper presents a case study examining 3rd, 4th and 5th graders’ design fixation and cooperative learning in an engineering design project. A mixed methods instrument, the Cooperative Learning Observation Protocol (CLOP, was adapted to record frequency and class observation on cooperative learning engagement through detailed field notes. Students’ design journals and reflections were also analyzed for an inductive qualitative analysis. The findings indicate three major themes of design fixation: 1 fixation on common features of things; 2 fixation on popular teenage culture; 3 fixation on the first design idea. In the cooperative learning process of elementary engineering design project, although pupils had demonstrated some abilities to solve concrete problems in a logical fashion, the participants encountered a number of obstacles in the group. Dominance, social loafing, and other problems occurring in the group process might have offset certain benefits of cooperative learning. Implications of the findings are also discussed.

Design fixation and cooperative learning in elementary engineering design project: A case study

Directory of Open Access Journals (Sweden)

Yi Luo

2015-09-01

Full Text Available This paper presents a case study examining 3rd, 4th and 5th graders’ design fixation and cooperative learning in an engineering design project. A mixed methods instrument, the Cooperative Learning Observation Protocol (CLOP, was adapted to record frequency and class observation on cooperative learning engagement through detailed field notes. Students’ design journals and reflections were also analyzed for an inductive qualitative analysis. The findings indicate three major themes of design fixation: 1 fixation on common features of things; 2 fixation on popular teenage culture; 3 fixation on the first design idea. In the cooperative learning process of elementary engineering design project, although pupils had demonstrated some abilities to solve concrete problems in a logical fashion, the participants encountered a number of obstacles in the group. Dominance, social loafing, and other problems occurring in the group process might have offset certain benefits of cooperative learning. Implications of the findings are also discussed.

Numbered head together with scientific approach in geometry learning

Science.gov (United States)

Indarti, Dwi; Mardiyana; Pramudya, Ikrar

2017-12-01

The aim of this research was to find out the influence of learning model implementation toward student’s achievement in mathematics. This research was using quasi-experimental research. The population of the research was all of 7th grade students in Karanganyar. Sample was taken using stratified cluster random sampling technique. The data collection has been conducted based on students’ mathematics achievement test. The results from the data analysis showed that the learning mathematics by using Numbered Head Together (NHT) learning model with scientific approach improved student’s achievement in mathematics rather than direct learning model particularly in learning object of quadrilateral. Implementation of NHT learning model with scientific approach could be used by the teachers in teaching and learning, particularly in learning object of quadrilateral.

Editorial - Keeping the Learning in Computer-Based Learning

Directory of Open Access Journals (Sweden)

William Kilbride

2002-09-01

Full Text Available Political rhetoric about knowledge economies and learning societies really ought to be an educationalist's dream. Add to that the revolutionary power of electronic media, and an insatiable hunger for archaeology among the public, archaeology teaching should be well placed to flourish. In England, the Department for Culture Media and Sport has just closed its call for interest in the multi-million pound Culture Online programme. The New Opportunities Fund has already spent fifty million pounds on digitisation alone, while the Heritage Lottery Fund is encouraging heritage agencies to distribute their data sets online. The JISC continues to expand its information environment, investing most recently in virtual learning environments. In Europe, the 6th Framework promises a single European Research Area, and grid technologies allow high quantities of data to empower an information society - supported by the millions of euros already invested in 'e-content'. All of these programmes, and many many more, provide openings for archaeologists to invest in training, teaching and learning. How can archaeology, in particular staff and students in our educational establishments, take best advantage of this information-rich, digitally-empowered learning society?

Profile of mathematics anxiety of 7th graders

Science.gov (United States)

Udil, Patrisius Afrisno; Kusmayadi, Tri Atmojo; Riyadi

2017-08-01

Mathematics anxiety is one of the important factors affect students mathematics achievement. This present research investigates profile of students' mathematics anxiety. This research focuses on analysis and description of students' mathematics anxiety level generally and its dominant domain and aspect. Qualitative research with case study strategy was used in this research. Subject in this research involved 15 students of 7th grade chosen with purposive sampling. Data in this research were students' mathematics anxiety scale result, interview record, and observation result during both mathematics learning activity and test. They were asked to complete mathematics anxiety scale before interviewed and observed. The results show that generally students' mathematics anxiety was identified in the moderate level. In addition, students' mathematics anxiety during mathematics test was identified in the high level, but it was in the moderate level during mathematics learning process. Based on the anxiety domain, students have a high mathematics anxiety on cognitive domain, while it was in the moderate level for psychological and physiological domains. On the other hand, it was identified in low level for psychological domain during mathematics learning process. Therefore, it can be concluded that students have serious and high anxiety regarding mathematics on the cognitive domain and mathematics test aspect.

Value Development Underlies the Benefits of Parents' Involvement in Children's Learning: A Longitudinal Investigation in the United States and China

Science.gov (United States)

Cheung, Cecilia Sin-Sze; Pomerantz, Eva M.

2015-01-01

This research examined whether the benefits of parents' involvement in children's learning are due in part to value development among children. Four times over the 7th and 8th grades, 825 American and Chinese children (M age = 12.73 years) reported on their parents' involvement in their learning and their perceptions of the value their parents…

Théories à processus duaux et théories de l’éducation : le cas de l’enseignement de la pensée critique et de la logique

Directory of Open Access Journals (Sweden)

Guillaume Beaulac

2011-05-01

Full Text Available Plusieurs théories de l’enseignement de la logique et de la pensée critique prennent pour acquis que l’apprentissage théorique, celui des règles formelles par exemple, et son application pratique sont suffisants pour maîtriser les outils enseignés et pour prendre l’habitude de les mettre en usage. Toutefois, tout indique que cet enseignement n’est pas efficace, une conclusion supportée par plusieurs travaux en sciences cognitives. Approcher l’étude de la cognition évolutionnairement avec les théories à processus duaux permet une explication de ces insuffisances, tout en offrant des pistes pour aborder l’enseignement de la pensée critique et de la logique de manière plus efficace. Dans cet article, nous souhaitons présenter cette approche et explorer ces pistes de solution afin de faire quelques recommandations pédagogiques et mettre en place un cadre théorique. Nous présenterons un exemple d’application de ce programme de recherche avec la philosophie pour enfants.Many theories about the teaching of logic and critical thinking take for granted that theoretical learning, the learning of formal rules for example, and its practical application are sufficient to master the tools taught and to take the habit of using them. However, this way of teaching is not efficient, a conclusion supported by much work in cognitive science. Approaching cognition evolutionarily with dual-process theories allows for an explanation of these insufficiencies and offers clues on how we could teach critical thinking and logic more efficiently. In this article, we want to present this approach and explore these leads in order to make some pedagogical recommendations and lay the foundations of a framework. We will put forward an example of the application of this research program with philosophy for children

Towards Mobile Learning Support for the Transition from School to the Workplace

NARCIS (Netherlands)

Glahn, Christian; Specht, Marcus; Wishart, Jocelyn

2011-01-01

Glahn, C., Specht, M., & Wishart J. (2010). Towards Mobile Learning Support for the Transition from School to the Workplace. Paper presented at the MATEL Workshop in conjunction with the 5th European Conference on Technology Enhanced Learning (EC-TEL 2010): Sustaining TEL: From Innovation to

Modulation of chicken macrophage effector function by Th1/Th2 cytokines

Science.gov (United States)

Regulation of macrophage activity by TH1/2 cytokines is important to maintain the balance of immunity to provide adequate protective immunity while avoiding excessive inflammation. IFN-gamma and IL-4 are the hallmark TH1 and TH2 cytokines, respectively. In avian species, information concerning reg...

Down-regulation of Notch signaling pathway reverses the Th1/Th2 imbalance in tuberculosis patients.

Science.gov (United States)

Li, Qifeng; Zhang, Hui; Yu, Liang; Wu, Chao; Luo, Xinhui; Sun, He; Ding, Jianbing

2018-01-01

Th1/Th2 imbalance to Th2 is of significance in the peripheral immune responses in Tuberculosis (TB) development. However, the mechanisms for Th1/Th2 imbalance are still not well determined. Notch signaling pathway is involved in the peripheral T cell activation and effector cell differentiation. However, whether it affects Th1/Th2 imbalance in TB patients is still not known. Here, we used γ-secretase inhibitor (DAPT) to treat the peripheral blood mononuclear cells (PBMCs) from healthy people or individuals with latent or active TB infection in vitro, respectively. Then, the Th1/Th2 ratios were determined by flow cytometry, and cytokines of IFN-γ, IL-4, IL-10 in the culture supernatant were measured by CBA method. The Notch signal pathway associated proteins Hes1, GATA3 and T-bet were quantitated by real-time PCR or immunoblotting. Our results showed that DAPT effectively inhibited the protein level of Hes1. In TB patients, the Th2 ratio increased in the PBMCs, alone with the high expression of GATA3 and IL-4, resulting in the high ratios of Th2/Th1 and GATA3/T-bet in TB patients. However, Th2 cells ratio decreased after blocking the Notch signaling pathway by DAPT and the Th2/Th1 ratio in TB patients were DAPT dose-dependent, accompanied by the decrease of IL-4 and GATA3. But, its influence on Th1 ratio and Th1 related T-bet and IFN-γ levels were not significant. In conclusion, our results suggest that blocking Notch signaling by DAPT could inhibit Th2 responses and restore Th1/Th2 imbalance in TB patients. Copyright © 2017. Published by Elsevier B.V.

Cunning Pedagogics: The Encounter between the Jesuit Missionaries and Amerindians in Th-Century New France

Science.gov (United States)

Welton, Michael

2005-01-01

The Jesuit encounter with the Amerindians of the St. Lawrence Valley in Th-century New France provides us with incalculable insights into the inner workings of the "colonial imagination" that believes the objects of instruction have everything to learn and nothing of value to teach. This article explicates how the Jesuits got to know their…

ADAPTATION OF THE STUDENTS' MOTIVATION TOWARDS SCIENCE LEARNING QUESTIONNAIRE TO MEASURE GREEK STUDENTS’ MOTIVATION TOWARDS BIOLOGY LEARNING

OpenAIRE

Andressa, Helen; Mavrikaki, Evangelia; Dermitzaki, Irini

2015-01-01

The purpose of this study was to investigate students’ motivation towards biology learning and to determine the factors that are related to it: students’ gender and their parents’ occupation (relevant with biology or not) were investigated. The sample of the study consisted of 360 Greek high school students of the 10th grade (178 boys and 182 girls). The data were collected through Students’ Motivation Toward Science Learning (SMTSL) questionnaire. It was found that it was a valid and reliabl...

Implementing Adaptive Educational Methods with IMS Learning Design

NARCIS (Netherlands)

Specht, Marcus; Burgos, Daniel

2006-01-01

Please, cite this publication as: Specht, M. & Burgos, D. (2006). Implementing Adaptive Educational Methods with IMS Learning Design. Proceedings of Adaptive Hypermedia. June, Dublin, Ireland. Retrieved June 30th, 2006, from http://dspace.learningnetworks.org

Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles.

Science.gov (United States)

Guimarães, Poliana Macedo; Scavuzzi, Bruna Miglioranza; Stadtlober, Nicole Perugini; Franchi Santos, Lorena Flor da Rosa; Lozovoy, Marcell Alysson Batisti; Iriyoda, Tatiana Mayumi Veiga; Costa, Neide Tomimura; Reiche, Edna Maria Vissoci; Maes, Michael; Dichi, Isaias; Simão, Andréa Name Colado

2017-10-01

The aims of this study were to delineate cytokine profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI) and vitamin D levels with cytokine levels. Two hundred SLE patients and 196 healthy controls participated in this case-control study. Plasma cytokines levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-1β, IL- 4, IL-6, IL-10, IL-12 and IL-17 were measured and cytokines profiles were computed. IL-6, IL-12, IL-17, IFN-γ and IL-10 levels were significantly higher in SLE, while IL-4 was lower in SLE. The Th1/Th2 and Th1+Th17/Th2 profiles were significantly higher in SLE than in healthy controls, whereas there were no significant differences in the proinflammatory cytokine profile (TNFα+IL-6+IL-1β). In total, 90.4% of all subjects were correctly classified using Th1+Th17 profile and IL-10 (positively associated) and IL-4 (negatively associated) as predictor variables (sensitivity=66.7% and specificity=96.9%). In all, 20.9% of the variance in the SLE Disease Activity Index was predicted by the Th1+Th17/Th2 ratio, IL-10 and BMI (all positively) and proinflammatory profile (inversely associated). B1/B1 genotype is accompanied by increased IL-17 and Th17/Th2 ratio, while B1/B2 genotype is accompanied by higher IL-4 and IFNγ values. 25-OH vitamin D was inversely associated with IFN-γ levels. SLE is accompanied by Th1, Th17 and Treg profile and lowered IL-4 production. Lowered vitamin D levels and B1/B1 genotype, but not BMI, contribute to changes in cytokines profiles. Future treatments should target Th1, Th2 and Th17 profiles rather than inflammatory cytokines.

Designing for Learning and Play - The Smiley Model as Framework

DEFF Research Database (Denmark)

Weitze, Charlotte Lærke

2016-01-01

digital games. The Smiley Model inspired and provided a scaffold or a heuristic for the overall gamified learning design –- as well as for the students’ learning game design processes when creating small games turning the learning situation into an engaging experience. The audience for the experiments......This paper presents a framework for designing engaging learning experiences in games – the Smiley Model. In this Design-Based Research project, student-game-designers were learning inside a gamified learning design - while designing and implementing learning goals from curriculum into the small...... was adult upper secondary general students as well as 7th grade primary school students. The intention with this article is to inspire future learning designers that would like to experiment with integrating learning and play....

History of the 4950th Test Group (N)

Science.gov (United States)

1957-10-15

57, ~ ~ 1 3 . 1 Concept of Air Tamk htp fOg20tl~m BPgp0-n Operation MPDTACT. 33. &el. 7r EXIHIEO Pirul Report b u r a t r , p. 2. 9. 8.0 pp...end t h a t t h i s headquarters would take no action which could be interpreted as attempting t o establish such policy. Consequently, this...ing supplies, PX and sales stores. a. Units of Task Groun 7.4 w i l l receive suppliee in accordance with procedures outlined in Air Foroe Manual

Distribution of Th-230 and Th-228 in food (I)

Energy Technology Data Exchange (ETDEWEB)

Kang, Hee Dong; Kim, Wan; Lim, X. J.; Choi, M. S.; Kim, C. J.; Zheng, Y. Z. [Kyungpook National Univ., Daegu (Korea, Republic of); Kim, Do Sung [Daegu Univ., Daegu (Korea, Republic of)

2003-03-15

Natural radioisotopes contained in foods can enter the human body by ingestion and contribute to internal doses to the population. It is necessary to measure the concentration of natural radioisotopes especially thorium in Korean foods and estimate the internal doses. In this study, we have established the thorium measuring process based on the thorium extraction chemical process and alpha spectroscopic method. The concentration of Th-228, Th-230 and Th-232 in Korean milk, meats(pork, beef and chicken) and grain (wheat, bean and rice) are measured and internal doses are estimated.

Modeling the Relations among Students' Epistemological Beliefs, Motivation, Learning Approach, and Achievement

Science.gov (United States)

Kizilgunes, Berna; Tekkaya, Ceren; Sungur, Semra

2009-01-01

The authors proposed a model to explain how epistemological beliefs, achievement motivation, and learning approach related to achievement. The authors assumed that epistemological beliefs influence achievement indirectly through their effect on achievement motivation and learning approach. Participants were 1,041 6th-grade students. Results of the…

An Analysis of the Educational Potential of Augmented Reality Games for Learning

NARCIS (Netherlands)

Schmitz, Birgit; Specht, Marcus; Klemke, Roland

2013-01-01

Schmitz, B., Specht, M., & Klemke, R. (2012). An Analysis of the Educational Potential of Augmented Reality Games for Learning. In M. Specht, J. Multisilta, & M. Sharples (Eds.), Proceedings of the 11th World Conference on Mobile and Contextual Learning 2012 (pp. 140-147). October, 16-18, 2012,

Effect of xanthohumol on Th1/Th2 balance in a breast cancer mouse model.

Science.gov (United States)

Zhang, Wenchao; Pan, Yanlong; Gou, Panhong; Zhou, Cheng; Ma, Lianqing; Liu, Qiming; Du, Yuping; Yang, Jinbo; Wang, Qin

2018-01-01

Xanthohumol (XN), a prenylflavonoid found in the hop plant, Humulus lupulus, exhibits a variety of biological activities. Numerous studies have reported that XN inhibits the growth of many types of cancer cells, but the effects of XN on tumor immunity have not yet been studied. We explored the effect of XN on Th1/Th2 balance and the underlying mechanism based on a BALB/c-4T1 breast cancer mouse model. The results showed that XN significantly slowed down tumor growth and inhibited expression of antitumor proliferation protein Ki-67 as well as breast cancer-specific marker cancer antigen 15-3 (CA15-3). Flow cytometric analysis revealed that XN enhanced the secretion of perforin, granzyme B and increased the ratio of CD8+/CD25+. ELISA analysis of cytokine results demonstrated that XN obviously upregulated Th1 cytokines, while downregulated Th2 cytokines. Th1/Th2 ratio analysis by flow cytometry illustrated that XN regulated the balance drift to Th1 polarization. Western blotting and immunohistochemistry (IHC) results manifested that XN induced expression of T-bet, a Th1-specific transcription factor. Furthermore, we found that XN significantly promoted the phosphorylation of signal transducer and activator of transcription (STAT)4. Our results demonstrated that XN promoted Th1/Th2 balance towards Th1 polarization, and STAT4 may play a positive role in the regulation of Th1/Th2 cytokines by XN.

Inductive Learning and Theory Testing: Applications in Finance

OpenAIRE

Zimmermann, Tom

2015-01-01

This thesis explores the opportunities for economic research that arise from importing empirical methods from the field of machine learning. Chapter 1 applies inductive learning to cross-sectional asset pricing. Researchers have documented over three hundred variables that can explain differences in cross-sectional stock returns. But which ones contain independent information? Chapter 1 develops a framework, deep conditional portfolio sorts, that can be used to answer this question and th...

Machine learning \\& artificial intelligence in the quantum domain

OpenAIRE

Dunjko, Vedran; Briegel, Hans J.

2017-01-01

Quantum information technologies, and intelligent learning systems, are both emergent technologies that will likely have a transforming impact on our society. The respective underlying fields of research -- quantum information (QI) versus machine learning (ML) and artificial intelligence (AI) -- have their own specific challenges, which have hitherto been investigated largely independently. However, in a growing body of recent work, researchers have been probing the question to what extent th...

The 30th Anniversary of Campylobacter, Helicobacter and Related Organisms Workshops – What Have We Learned In Three Decades?

Directory of Open Access Journals (Sweden)

Christine M Szymanski

2012-02-01

Full Text Available As we commemorate the 30th anniversary of the Campylobacter, Helicobacter and Related Organisms (CHRO workshops with this special Frontiers edition, we look back upon three decades of research and provide some highlights from the 16th International CHRO meeting. As Martin Skirrow noted, Elizabeth King was the first to isolate campylobacters in the 1950’s, although Escherich himself provided drawings of these fecal organisms back in the 1880’s. Helicobacter is a more recent organism, first described to be the causative agent of stomach ulcers at a CHRO meeting by Barry Marshall and Robin Warren – who then later received the Nobel Prize for their findings that bacteria could cause diseases previously believed to be caused by human factors. Studies of the intersection of host microbial ecology and pathogen infection have been pioneered by scientists such as Brett Finlay, who described his current work on this topic. And as general antibiotics are routinely administered, we see a rise in bacterial antibiotic resistance. Julian Davies emphasized that there is a growing need for the development of new bioactive compounds on the horizon as we advance our knowledge on these pathogens. The first genome of C. jejuni was published in 2000; now one decade later we have 30 Campyobacter taxa sequenced, and this number continues to rise quickly. However, we continue to obtain unexpected results as a pioneer in CHRO research, Martin Blaser explained – i.e., although H. pylori is now classified as a level I carcinogen, there may be benefits to carrying this organism as part of your normal flora. Other findings indicate that Campylobacters and Helicobacters do not follow classic paradigms of other well-characterized gastrointestinal pathogens. And we are learning that there is a whole world of interesting related organisms beyond C. jejuni and H. pylori. This review summarizes some of the history of CHRO research and the exciting directions ahead.

Radiation-induced decrease of CD8+ dendritic cells contributes to Th1/Th2 shift.

Science.gov (United States)

Liu, Hu; Li, Bailong; Jia, Xiaojing; Ma, Yan; Gu, Yifeng; Zhang, Pei; Wei, Qun; Cai, Jianming; Cui, Jianguo; Gao, Fu; Yang, Yanyong

2017-05-01

Exposure to ionizing radiation (IR) often reduce the helper T (Th) 1 like function, resulting in a Th1/Th2 imbalance, which could affect the efficacy of cancer radiotherapy. As the most potent antigen presenting cells, dendritic cells (DC) can be divided into several subsets with specialized function. However, there is no literature covering the changes of DC subsets and their roles in immune regulation in response to IR. In the present study, we were aimed to investigate the changes of DC subsets after IR and its relationship with Th1/Th2 immunity. We found a significant decrease of BDCA3+DC in the blood of patients treated with radiotherapy. CD8+DC, a mouse equivalent of human BDCA3+DC, was also found decreased in mice spleen, peripheral blood and lymph node tissues after irradiation. As CD8+DC mainly induce Th1 immunity, we tested the changes of Th1/Th2 response and found that IR caused a repression of Th1 immunity, indicating a possible role of CD8+DC in radiation-induced Th1/Th2 imbalance. We also found that a CD8+DC-inducing cytokine, Fms-like tyrosine kinase 3 ligand (FLT3 ligand), restored CD8+DC and reversed Th1/Th2 shift. And then we found that bone marrow cells from irradiated mice differentiated into less CD8+DC, which was also protected by FLT3 ligand. In conclusion, our data showed that IR induced a decrease of CD8+DC and Th1/Th2 shift, which was reversed by Flt3 ligand treatment, suggesting a novel mechanism for radiation-induced immunosuppression. Copyright © 2017. Published by Elsevier B.V.

e-Portfolios for Learning and Development: without constant internet or electrical grid access

NARCIS (Netherlands)

Casey, John; Calverley, Gayle; Greller, Wolfgang; Uhomoibhi, James

2011-01-01

Casey, J., Calverley, G., Greller, W., & Uhomoibhi, J. (2010, 26-28 May). e-Portfolios for Learning and Development: without constant internet or electrical grid access. Presentation at the 5th International Conference on ICT for Development, Education, and Training - eLearning Africa, Lusaka,

Structural phase stability of ThSb and ThAs under pressure

International Nuclear Information System (INIS)

Venkatasubramaniam, K.; Rajagopalan, M.; Palanivel, B.; Kalpana, G.

1997-01-01

The high-pressure behaviour of thorium monopnictides is of considerable interest as these systems exhibit structural phase transitions under pressure. At ambient conditions these compounds crystallize in the NaCl-type(B1) structure. Experiments show that with the application of pressure these compounds transform to the CsCl-type (B2) structure. ThSb and ThAs are found to exhibit B1-B2 transition in the pressure range between 9-12 GPa and 1826 GPa respectively. In this work, we present the electronic and high-pressure behaviour of ThAs and ThSb performed using the tight-binding linear muffin-tin orbital method. The total energies within the atomic sphere approximation were calculated as a function of volume for both the B1 and B2 structures. The total energy calculations reveal that both ThSb and ThAs are stable in the B1 structure at ambient conditions and undergo structural transition to the B2 structure at pressures 78 and 240 kbar respectively, which are in good agreement with the experimental values. The calculated values of equilibrium lattice parameter and the transition pressure are found to be in good agreement with the experimental results. (author)

Improved Student Reasoning About Carbon-Transforming Processes Through Inquiry-Based Learning Activities Derived from an Empirically Validated Learning Progression

Science.gov (United States)

JW, Schramm; Jin, H.; Keeling, EG; Johnson, M.; Shin, HJ

2017-05-01

This paper reports on our use of a fine-grained learning progression to assess secondary students' reasoning through carbon-transforming processes (photosynthesis, respiration, biosynthesis). Based on previous studies, we developed a learning progression with four progress variables: explaining mass changes, explaining energy transformations, explaining subsystems, and explaining large-scale systems. For this study, we developed a 2-week teaching module integrating these progress variables. Students were assessed before and after instruction, with the learning progression framework driving data analysis. Our work revealed significant overall learning gains for all students, with the mean post-test person proficiency estimates higher by 0.6 logits than the pre-test proficiency estimates. Further, instructional effects were statistically similar across all grades included in the study (7th-12th) with students in the lowest third of initial proficiency evidencing the largest learning gains. Students showed significant gains in explaining the processes of photosynthesis and respiration and in explaining transformations of mass and energy, areas where prior research has shown that student misconceptions are prevalent. Student gains on items about large-scale systems were higher than with other variables (although absolute proficiency was still lower). Gains across each of the biological processes tested were similar, despite the different levels of emphasis each had in the teaching unit. Together, these results indicate that students can benefit from instruction addressing these processes more explicitly. This requires pedagogical design quite different from that usually practiced with students at this level.

Th1, Th17, CXCL16 and homocysteine elevated after intracranial and cervical stent implantation.

Science.gov (United States)

Tang, Yanyan; Wei, Yunfei; Ye, Ziming; Qin, Chao

2017-08-01

The presence of Th1 and Th17 cells has been observed as major inducers in inflammation and immune responses associated stenting. However, there is rare data on the impact of Th1, Th17, CXCL16 and homocysteine after cerebral stent implantation. Here, we performed the statistical analysis to first evaluate the variation of the Th17and Th1 cells and their related cytokines, CXCL16 and homocysteine in the peripheral blood of patients with cerebral stenting. The flow cytometry was used to detect the proportion of Th1 and Th17 cells in peripheral blood mononuclear cells (PBMCs). The enzyme-linked immunosorbent assay was used to measure the serum concentrations of IFN-γ, IL-17 and CXCL16. Plasma homocysteine was examined by immunoturbidimetry. The level of Th1, CXCL16 and homocysteine showed an increase at 3 d, followed by the continuous decrease at 7 d and 3 months. The frequency of Th17 cells increased to a peak at three days, and subsequently decreased with a higher level than baseline. Our data revealed that the variation in Th1, Th17, CXCL16 and homocysteine in peripheral blood of patients with stenting may be implicated in inflammation after intracranial and cervical stent implantation. A better understanding of these factors will provide help for further drug design and clinical therapy.

Effects of PARP-1 Deficiency on Th1 and Th2 Cell Differentiation

Directory of Open Access Journals (Sweden)

M. Sambucci

2013-01-01

Full Text Available T cell differentiation to effector Th cells such as Th1 and Th2 requires the integration of multiple synergic and antagonist signals. Poly(ADP-ribosylation is a posttranslational modification of proteins catalyzed by Poly(ADP-ribose polymerases (PARPs. Recently, many reports showed that PARP-1, the prototypical member of the PARP family, plays a role in immune/inflammatory responses. Consistently, its enzymatic inhibition confers protection in several models of immune-mediated diseases, mainly through an inhibitory effect on NF-κB (and NFAT activation. PARP-1 regulates cell functions in many types of immune cells, including dendritic cells, macrophages, and T and B lymphocytes. Our results show that PARP-1KO cells displayed a reduced ability to differentiate in Th2 cells. Under both nonskewing and Th2-polarizing conditions, naïve CD4 cells from PARP-1KO mice generated a reduced frequency of IL-4+ cells, produced less IL-5, and expressed GATA-3 at lower levels compared with cells from wild type mice. Conversely, PARP-1 deficiency did not substantially affect differentiation to Th1 cells. Indeed, the frequency of IFN-γ+ cells as well as IFN-γ production, in nonskewing and Th1-polarizing conditions, was not affected by PARP-1 gene ablation. These findings demonstrate that PARP-1 plays a relevant role in Th2 cell differentiation and it might be a target to be exploited for the modulation of Th2-dependent immune-mediated diseases.

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

Science.gov (United States)

Prajeeth, Chittappen K; Kronisch, Julius; Khorooshi, Reza; Knier, Benjamin; Toft-Hansen, Henrik; Gudi, Viktoria; Floess, Stefan; Huehn, Jochen; Owens, Trevor; Korn, Thomas; Stangel, Martin

2017-10-16

Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously, we have shown that only Th1 but not Th17 effectors activate microglia. However, it is not clear which cells are targets of Th17 effectors in the CNS. To understand the effects driven by Th17 cells in the CNS, we induced experimental autoimmune encephalomyelitis in wild-type mice and CD4 + T cell-specific integrin α4-deficient mice where trafficking of Th1 cells into the CNS was affected. We compared microglial and astrocyte response in the brain and spinal cord of these mice. We further treated astrocytes with supernatants from highly pure Th1 and Th17 cultures and assessed the messenger RNA expression of neurotrophic factors, cytokines and chemokines, using real-time PCR. Data obtained was analyzed using the Kruskal-Wallis test. We observed in α4-deficient mice weak microglial activation but comparable astrogliosis to that of wild-type mice in the regions of the brain populated with Th17 infiltrates, suggesting that Th17 cells target astrocytes and not microglia. In vitro, in response to supernatants from Th1 and Th17 cultures, astrocytes showed altered expression of neurotrophic factors, pro-inflammatory cytokines and chemokines. Furthermore, increased expression of chemokines in Th1- and Th17-treated astrocytes enhanced recruitment of microglia and transendothelial migration of Th17 cells in vitro. Our results demonstrate the delicate interaction between T cell subsets and glial cells and how they communicate to mediate their effects. Effectors of Th1 act on both microglia and astrocytes whereas Th17 effectors preferentially target astrocytes to promote neuroinflammation.

Cloning and Characterization of ThSHRs and ThSCR Transcription Factors in Taxodium Hybrid 'Zhongshanshan 406'.

Science.gov (United States)

Wang, Zhiquan; Yin, Yunlong; Hua, Jianfeng; Fan, Wencai; Yu, Chaoguang; Xuan, Lei; Yu, Fangyuan

2017-07-20

Among the GRAS family of transcription factors, SHORT ROOT (SHR) and SCARECROW (SCR) are key regulators of the formation of root tissues. In this study, we isolated and characterized two genes encoding SHR proteins and one gene encoding an SCR protein: ThSHR1 (Accession Number MF045148), ThSHR2 (Accession Number MF045149) and ThSCR (Accession Number MF045152) in the adventitious roots of Taxodium hybrid 'Zhongshanshan'. Gene structure analysis indicated that ThSHR1 , ThSHR2 and ThSCR are all intron free. Multiple protein sequence alignments showed that each of the corresponding proteins, ThSHR1, ThSHR2 and ThSCR, contained five well-conserved domains: leucine heptad repeat I (LHRI), the VHIID motif, leucine heptad repeat II (LHR II), the PFYRE motif, and the SAW motif. The phylogenetic analysis indicated that ThSCR was positioned in the SCR clade with the SCR proteins from eight other species, while ThSHR1 and ThSHR2 were positioned in the SHR clade with the SHR proteins from six other species. Temporal expression patterns of these genes were profiled during the process of adventitious root development on stem cuttings. Whereas expression of both ThSHR2 and ThSCR increased up to primary root formation before declining, that of ThSHR1 increased steadily throughout adventitious root formation. Subcellular localization studies in transgenic poplar protoplasts revealed that ThSHR1, ThSHR2 and ThSCR were localized in the nucleus. Collectively, these results suggest that the three genes encode Taxodium GRAS family transcription factors, and the findings contribute to improving our understanding of the expression and function of SHR and SCR during adventitious root production, which may then be manipulated to achieve high rates of asexual propagation of valuable tree species.

Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance

Science.gov (United States)

Martino, Matteo; Rocchi, Giulio; Escelsior, Andrea; Fornaro, Michele

2012-01-01

Neurotransmitters and hormones regulate major immune functions, including the selection of T helper (Th)1 or Th2 cytokine responses, related to cell-mediated and humoral immunity, respectively. A role of imbalance and dynamic switching of Th1/Th2 system has been proposed, with relative displacement of the immune reserve in relation to complex interaction between Th1/Th2 and neuro-hormonal balance fluctuations, in the pathogenesis of various chronic human diseases, probably also including psychiatric disorders. Components of the stress system such as norepinephrine (NE) and glucocorticoids appear to mediate a Th2 shift, while serotonin (5-HT) and melatonin might mediate a Th1 shift. Some antidepressants would occur affecting these systems, acting on neurotransmitter balance (especially the 5-HT/NE balance) and expression levels of receptor subtypes, which in turn affect cytokine production and relative Th1/Th2 balance. It could be therefore hypothesized that the antidepressant-related increase in NE tone enhances the Th2 response, while the decrease in NE tone or the increase in 5-HT tone enhances the Th1 response. However, the neurotransmitter and Th1/Th2 balance modulation could be relative, aiming to restore physiological levels a previous imbalance in receptor sensitivity and cytokine production. The considerations on neuro-immunomodulation could represent an additional aid in the study of pathophysiology of psychiatric disorders and in the choice of specific antidepressants in specific clusters of symptoms, especially in comorbidity with internal pathologies. Furthermore limited data, reviewed here, have shown the effectiveness of some antidepressants as pure immunomodulators. However, these considerations are tentative and require experimental confirmation or refutation by future studies. PMID:23204981

Analysis of the learning curve for peroral endoscopic myotomy for esophageal achalasia: Single-center, two-operator experience.

Science.gov (United States)

Lv, Houning; Zhao, Ningning; Zheng, Zhongqing; Wang, Tao; Yang, Fang; Jiang, Xihui; Lin, Lin; Sun, Chao; Wang, Bangmao

2017-05-01

Peroral endoscopic myotomy (POEM) has emerged as an advanced technique for the treatment of achalasia, and defining the learning curve is mandatory. From August 2011 to June 2014, two operators in our institution (A&B) carried out POEM on 35 and 33 consecutive patients, respectively. Moving average and cumulative sum (CUSUM) methods were used to analyze the POEM learning curve for corrected operative time (cOT), referring to duration of per centimeter myotomy. Additionally, perioperative outcomes were compared among distinct learning curve phases. Using the moving average method, cOT reached a plateau at the 29th case and at the 24th case for operators A and B, respectively. CUSUM analysis identified three phases: initial learning period (Phase 1), efficiency period (Phase 2) and mastery period (Phase 3). The relatively smooth state in the CUSUM graph occurred at the 26th case and at the 24th case for operators A and B, respectively. Mean cOT of distinct phases for operator A were 8.32, 5.20 and 3.97 min, whereas they were 5.99, 3.06 and 3.75 min for operator B, respectively. Eckardt score and lower esophageal sphincter pressure significantly decreased during the 1-year follow-up period. Data were comparable regarding patient characteristics and perioperative outcomes. This single-center study demonstrated that expert endoscopists with experience in esophageal endoscopic submucosal dissection reached a plateau in learning of POEM after approximately 25 cases. © 2016 Japan Gastroenterological Endoscopy Society.

CALL in a Climate of Change: Adapting to Turbulent Global Conditions. Short Papers from EUROCALL 2017 (25th, Southampton, United Kingdom, August 23-26, 2017)

Science.gov (United States)

Borthwick, Kate, Ed.; Bradley, Linda, Ed.; Thouësny, Sylvie, Ed.

2017-01-01

The 25th European Association of Computer-Assisted Language Learning (EUROCALL) conference was hosted by Modern Languages and Linguistics at the University of Southampton, in the United Kingdom, from the 23rd to the 26th of August 2017. The theme of the conference was "CALL in a climate of change." The theme encompassed the notion of how…

Improving Problem Solving Skill and Self Regulated Learning of Senior High School Students through Scientific Approach using Quantum Learning strategy

Directory of Open Access Journals (Sweden)

M Sudirman

2017-12-01

Full Text Available This research is quasi experiment with control group pretest-postest design. The sampel in this research using the techique of purposive sampling so the samples used were two classes of the 11th grade students of SMAN 14 Bandung in the academic year 2017/2018. The experiment group uses saintific approach using Quantum Learning strategy and control group uses saintific approach. In collecting the data the researcher will use the test of problem solving ability and self regulated learning as the instrument. The aims of this research are to:1find out the improvement of students mathematical problem solving through scientific approach using Quantum Learning study, 2 find out students self regulated learning through scientific approach using Quantum Learning.

AN OVERVIEW OF CLOUD COMPUTING FOR E-LEARNING WITH ITS KEY BENEFITS

OpenAIRE

Mansi Bosamia

2018-01-01

Education is a necessary human virtue and essential for society because it reflects the personality of the human being in our society. The effective way of teaching gives the quality of education and advance learning such as e-learning to the learners and also a high quality of teaching to the tutors. Information Technology (IT) plays a significant role in field of education. Now days, E-learning and M-learning have become very popular trends of the education technology riot. E-Learning is th...

Selected Lectures of the 13th International Workshop on Neonatology; Cagliari (Italy); October 25th-28th, 2017

OpenAIRE

--- Various Authors

2017-01-01