WorldWideScience

Sample records for learned headquarters 1st

  1. 17 CFR 140.1 - Headquarters office.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Headquarters office. 140.1..., FUNCTIONS, AND PROCEDURES OF THE COMMISSION Organization § 140.1 Headquarters office. (a) General. The headquarters office of the Commission is located at Three Lafayette Centre, 1155 21st Street, NW., Washington...

  2. 39 CFR 223.1 - Headquarters and areas.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Headquarters and areas. 223.1 Section 223.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELATIONSHIPS AND COMMUNICATION CHANNELS § 223.1 Headquarters and areas. Headquarters provides policy guidance, procedures, and...

  3. 7 CFR 2003.5 - Headquarters organization.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Headquarters organization. 2003.5 Section 2003.5...) ADMINISTRATIVE REGULATIONS ORGANIZATION Functional Organization of the Rural Development Mission Area § 2003.5 Headquarters organization. (a) The Rural Development Headquarters is comprised of: (1) The Office of the Under...

  4. Selected DOE headquarters publications

    International Nuclear Information System (INIS)

    1979-04-01

    This publication provides listings of (mainly policy and programmatic) publications which have been issued by headquarters organizations of the Department of Energy; assigned a DOE/XXX- type report number code, where XXX is the 1- to 4-letter code for the issuing headquarters organization; received by the Energy Library; and made available to the public

  5. St. Louis FUSRAP Lessons Learned

    International Nuclear Information System (INIS)

    Eberlin, J.; Williams, D.; Mueller, D.

    2003-01-01

    The purpose of this paper is to present lessons learned from fours years' experience conducting Remedial Investigation and Remedial Action activities at the St. Louis Downtown Site (SLDS) under the Formerly Utilized Sites Remedial Action Program (FUSRAP). Many FUSRAP sites are experiencing challenges conducting Remedial Actions within forecasted volume and budget estimates. The St. Louis FUSRAP lessons learned provide insight to options for cost effective remediation at FUSRAP sites. The lessons learned are focused on project planning (budget and schedule), investigation, design, and construction

  6. 39 CFR 221.5 - Headquarters organization.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Headquarters organization. 221.5 Section 221.5 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION GENERAL ORGANIZATION § 221.5 Headquarters organization. (a) Postmaster General—(1) Appointment. The postmaster general (PMG), the chief...

  7. MNC Headquarters as Activity Systems

    DEFF Research Database (Denmark)

    Nell, Phillip C.; Larsen, Marcus M.

    2012-01-01

    Recent literature has questioned why multinational corporations (MNC) relocate their headquarters activities overseas. In this paper, we investigate the consequences of this phenomenon. To do this, we conceptualize the MNC headquarters activities as an interdependent system, and develop a set...... of propositions that links headquarters unbundling and relocation to complexity and rising coordination costs. Moreover, we argue that the coordination costs are often neglected in the headquarters reconfiguration process. In sum, we provide a novel perspective on modern MNC headquarters configurations, derive...

  8. DOE headquarters publications

    International Nuclear Information System (INIS)

    1978-09-01

    This bibliography provides listings of (mainly policy and programmatic) publications issued from the U.S. Department of Energy, Washington, D.C. The listings are arranged by the ''report code'' assigned to each of the major organizations at DOE Headquarters, followed by the three categories of environmental reports issued from DOE Headquarters. All of the publications listed, except for those shown as still ''in preparation,'' may be seen in the Energy Library. A title index arranged by title keywords follows the listings. Certain publications are omitted. They include such items as pamphlets, ''fact sheets,'' bulletins and weekly/monthly issuances of DOE's Energy Information Administration and Economic Regulatory Administration, and employee bulletins and newsletters. Omitted from the bibliography altogether are headquarters publications assigned other types of report codes--e.g., ''HCP'' (Headquarters Contractor Publication) and ''CONF'' (conference proceedings)

  9. ERDA Headquarters reports: March 1977

    International Nuclear Information System (INIS)

    1977-03-01

    ERDA headquarters reports (ERDA 77-41) provides a cumulative record, through various lists and an index, of the reports issued from ERDA Headquarters (''ERDA Reports''). The four sections of this publication are New ERDA Reports, a list of Headquarters reports received in the ERDA Library during the past month; Cumulative List of ERDA Reports, all ERDA Headquarters reports already issued or scheduled to be issued; Reports by Program Division, separate lists of ERDA reports arranged by the division or office at ERDA Headquarters responsible for their preparation and/or issuance; and Index to Keywords in Report Titles

  10. DOE headquarters publications

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-09-01

    This bibliography provides listings of (mainly policy and programmatic) publications issued from the U.S. Department of Energy, Washington, D.C. The listings are arranged by the ''report code'' assigned to each of the major organizations at DOE Headquarters, followed by the three categories of environmental reports issued from DOE Headquarters. All of the publications listed, except for those shown as still ''in preparation,'' may be seen in the Energy Library. A title index arranged by title keywords follows the listings. Certain publications are omitted. They include such items as pamphlets, ''fact sheets,'' bulletins and weekly/monthly issuances of DOE's Energy Information Administration and Economic Regulatory Administration, and employee bulletins and newsletters. Omitted from the bibliography altogether are headquarters publications assigned other types of report codes--e.g., ''HCP'' (Headquarters Contractor Publication) and ''CONF'' (conference proceedings). (RWR)

  11. Beyond Simple Headquarters Configurations

    DEFF Research Database (Denmark)

    Dellestrand, Henrik; Kappen, Philip; Nell, Phillip Christopher

    We investigate “dual headquarters involvement”, i.e. corporate and divisional headquarters’ simultaneous involvement in subsidiaries’ innovation development projects. Analyses draw on 85 innovation projects in 23 multibusiness firms and reveal that cross-divisional innovation importance, i.......e., an innovation that is important for the firm beyond the divisional boundaries, drives dual headquarters involvement in innovation development. Contrary to expectations, on average, a non-significant effect of cross-divisional embeddedness on dual headquarters involvement is found. Yet, both cross......-divisional importance and embeddedness effects are contingent on the overall complexity of the innovation project as signified by the size of the development network. The results lend support for the notion that parenting in complex structures entails complex headquarters structures and that we need to go beyond simple...

  12. Cooperative learning in 21st century

    Directory of Open Access Journals (Sweden)

    David W. Johnson

    2014-10-01

    Full Text Available The 21st century brings four important challenges in which cooperation plays a central role: (1 a rapidly increasing global interdependence that will result in increasing local diversity as well as more frequent and intense conflicts, (2 the increasing number of democracies throughout the world, (3 the need for creative entrepreneurs, and (4 the growing importance of interpersonal relationships that affect the development of personal identity. The tools for meeting these challenges include cooperative learning. In this article the nature of cooperative learning will be reviewed, the underlying theory of social interdependence will be discussed, and the results of the research on cooperative learning will be briefly reviewed. The way in which cooperative learning contributes to meeting the four challenges will then be discussed.

  13. The Effect of Video-Assisted Inquiry Modified Learning Model on Student’s Achievement on 1st Fundamental Physics Practice

    Directory of Open Access Journals (Sweden)

    T W Maduretno

    2017-12-01

    Full Text Available The purpose of research are: (1 to know the effect of video-assisted inquiry modified learning model on student’s achievement; (2 to improve the student’s achievement in 1st Fundamental Physics Practice through video-assisted inquiry modified learning model. The student’s achievement as dependent variables includes the aspects of knowledge, skill, and attitude. The sampling technique did not choose at random. The Mathematics Education as the control group and the Science Education as the experimental group. The experimental group used video-assisted inquiry modified learning model and the control group used inquiry learning model. The collecting data technique used observation, questionnaire, and test. The researcher used the independent t-test that purposed to compare the average of achievement of control and experiment group. The results of research were: (1 there was an effect of video-assisted inquiry modified learning model on the knowledge and skill aspect but there was not on the attitude aspect; (2 The average of learning outcome of the experimental group higher than the control group’s; (3 The video-assisted inquiry modified learning model helped more skilled and trained student to discovery, inquiry the scientific principle, experiment and observation, and explain the experiment and observation’s result so that the students be able to understand the materials on the 1st Fundamental Physics Practice.

  14. Teachers' Spatial Anxiety Relates to 1st-and 2nd-Graders' Spatial Learning

    Science.gov (United States)

    Gunderson, Elizabeth A.; Ramirez, Gerardo; Beilock, Sian L.; Levine, Susan C.

    2013-01-01

    Teachers' anxiety about an academic domain, such as math, can impact students' learning in that domain. We asked whether this relation held in the domain of spatial skill, given the importance of spatial skill for success in math and science and its malleability at a young age. We measured 1st-and 2nd-grade teachers' spatial anxiety…

  15. Developing 21st Century Skills through a Constructivist-Constructionist Learning Environment

    Directory of Open Access Journals (Sweden)

    Lay Ah-Nam

    2017-04-01

    Full Text Available Science and technology innovation and 21st century skills are increasingly important in the 21st century workplace. The purpose of this study is to propose an instructional strategy that develop constructivist-constructionist learning environment that simultaneously develop chemistry knowledge and 21st century skills. Based on constructivist and constructionist learning theories, we identified three central guiding principles for this study: (1 engage students in discovery and problem solving task through teamwork, (2 provide opportunities for communicating ideas, and (3 involve students in the process of design. An intervention module, Malaysian Kimia (chemistry Digital Game known as MyKimDG, was developed as a mechanism for creating the learning environment. In this study, students were required to work collaboratively to design educational media that help their peers who face difficulty in learning particular concept. They were guided to go through the IDPCR (Inquiry, Discover, Produce, Communicate and Review phases. It is hypothesized that MyKimDG can create learning environment that allows students to deepen subject content knowledge and practice various 21st century skills in real situation. This study employed quasi-experimental study with non-equivalent control group pretest-posttest control group design. Results suggest that this approach is able to improve the acquisition of chemistry knowledge and high productivity skill.

  16. 1st IAEA research co-ordination meeting on charge exchange cross section data for fusion plasma studies. Summary report

    International Nuclear Information System (INIS)

    Janev, R.K.

    1999-02-01

    A brief description of the proceedings and the conclusions of the 1st Research Coordination Meeting on 'Charge Exchange Cross Section Data for Fusion Plasma Studies', held on September 24-25, 1999, at the IAEA Headquarters in Vienna, Austria, is provided. The conclusions of the Meeting regarding the data collection, assessment and generation priorities are also included in the report. (author)

  17. Learning Analytics for 21st Century Competencies

    Science.gov (United States)

    Buckingham Shum, Simon; Crick, Ruth Deakin

    2016-01-01

    Many educational institutions are shifting their teaching and learning towards equipping students with knowledge, skills, and dispositions that prepare them for lifelong learning, in a complex and uncertain world. These have been termed "21st century competencies." Learning analytics (LA) approaches in general offer different kinds of…

  18. 7 CFR 1726.150 - Headquarters buildings.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Headquarters buildings. 1726.150 Section 1726.150... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Buildings § 1726.150 Headquarters buildings. This section includes headquarters buildings such as warehouses and equipment service type buildings...

  19. Dual Headquarters Involvement in Subsidiary Innovation

    DEFF Research Database (Denmark)

    Dellestrand, Henrik; Kappen, Philip; Nell, Phillip Christopher

    2014-01-01

    The strategy and international business literature has identified the overall potential for headquarters to add value by allocating resources to subsidiary activities, but little is known about the extent to which multiple headquarters simultaneously involves itself in subsidiary operations....... The current paper takes on this neglected question by empirically investigating corporate and divisional headquarters direct involvement in innovation development projects at the subsidiary level. Analyses that draw upon 85 innovation development projects in 23 multinational enterprises reveal that dual...... of the developing subsidiary positively moderates the two aforementioned effects on dual headquarters involvement in innovation development. The results lend support for the notion that parenting in complex structures entails complex headquarters structures. Thus, the results question simplistic views...

  20. 7 CFR 2610.2 - Headquarters organization.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Headquarters organization. 2610.2 Section 2610.2... OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 2610.2 Headquarters organization. (a) The OIG has a headquarters office in Washington, DC, and regional offices throughout the...

  1. Selected DOE headquarters publications, October 1979

    International Nuclear Information System (INIS)

    1981-03-01

    A cumulative listing of DOE headquarters publications issued since October 1979 is provided along with an index of title keywords. Three types of headquarters publications have been included: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations; reports prepared by contractors (and published by DOE headquarters) to describe research and development work they have performed for the department; and environmental development plans, environmental impact statements, and environmental readiness documents. Availabilities of documents are given

  2. Selected DOE headquarters publications, October 1979

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-03-01

    A cumulative listing of DOE headquarters publications issued since October 1979 is provided along with an index of title keywords. Three types of headquarters publications have been included: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations; reports prepared by contractors (and published by DOE headquarters) to describe research and development work they have performed for the department; and environmental development plans, environmental impact statements, and environmental readiness documents. Availabilities of documents are given. (GHT)

  3. Selected DOE Headquarters publications, October 1977-September 1979

    International Nuclear Information System (INIS)

    1979-11-01

    This sixth issue of cumulative listings of DOE Headquarters publications covers the first two years of the Department's operation (October 1, 1977 - September 30, 1979). It lists two groups of publications issued by then-existing Headquarters organizations and provides an index to their title keywords. The two groups of publications are publications assigned a DOE/XXX-type report number code and Headquarters contractor reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department. Certain publications are omitted. They include such items as pamphlets, fact sheets, bulletins, newsletters, and telephone directories, as well as headquarters publications issued under the DOE-tr (DOE translation) and CONF (conference proceedings) codes, and technical reports from the Jet Propulsion Laboratory and NASA issued under DOE/JPL and DOE/NASA codes. The contents of this issue will not be repeated in subsequent issues of DOE/AD-0010

  4. 21st Century leadership skills for learning networks

    NARCIS (Netherlands)

    Basten, Floor; Evers, Arnoud; Geijsel, Femke; Vermeulen, Marjan

    2018-01-01

    Ultimate goal: to prepare pupils for a life in a society that requires 21st century skills and actions Immediate focus: teachers and principals develop 21st century skills in the practice of their work → together with researchers principals co-create tools to support teacher learning.

  5. Does Distance to Subsidiaries affect Headquarters Value Added?

    DEFF Research Database (Denmark)

    Nell, Phillip C.; Beugelsdijk, Sjoerd; Ambos, Björn

    2014-01-01

    How does distance between MNC headquarters and their subsidiaries affect the value added generated by headquarters? Integrating theories on spatial transaction costs with the headquarter view of the MNC, we link two types of distances, geographic distance and contextual distance, with headquarters...... value added. We test our hypotheses on an original dataset of 124 manufacturing subsidiaries in Europe. We find that the relation between distance and headquarters value added is conditional on the degree of subsidiaries’ external embeddedness. We find no direct effect of distance. The value added...... of headquarters is highest for subsidiaries that are not externally embedded in the host country and that operate at a large distance. It is lowest for locally responsive subsidiaries with high external embeddedness operating at a large distance. We discuss implications for the literature on headquarters-subsidiaries...

  6. Dual Headquarters Involvement in Multibusiness Firms

    DEFF Research Database (Denmark)

    Nell, Phillip Christopher; Kappen, Philip; Dellestrand, Henrik

    The strategy literature has shown that headquarters involve themselves into subsidiary operations to add value. Yet, little is known about the extent to which multiple headquarters do so. Therefore, we investigate antecedents of corporate and divisional headquarters’ involvement in innovation...... development projects of subsidiaries. Analyses of 85 innovation development projects reveal that dual innovation importance (innovation that is important for the division and the rest of the firm), and dual dual embeddedness (innovating subsidiary is embedded both within the division and in the rest...... of the firm) lead to greater dual headquarters involvement, especially when the innovation development network is large. The results contribute to the literature on complex parenting and theory of selective headquarters involvement....

  7. Selected DOE Headquarters publications, October 1979

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-07-01

    This publication provides cumulative listings of and an index to DOE headquarters publications issued since October 1979. Three types of headquarters publications are included: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations, reports prepared by contractors to describe research and development work they have performed for the Department, and environmental development plans and impact statements. Such items as pamphlets, fact sheets, bulletins, newsletters, telephone directories, headquarters publications issued under the DOE-tr and CONF codes, technical reports from the Jet Propulsion Laboratory and NASA issued under DOE/JPL and DOE/NASA codes, and weekly/monthly reports of the Energy Information Administration are not included. (RWR)

  8. Selected DOE Headquarters publications, October 1977-September 1979

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-11-01

    This sixth issue of cumulative listings of DOE Headquarters publications covers the first two years of the Department's operation (October 1, 1977 - September 30, 1979). It lists two groups of publications issued by then-existing Headquarters organizations and provides an index to their title keywords. The two groups of publications are publications assigned a DOE/XXX-type report number code and Headquarters contractor reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department. Certain publications are omitted. They include such items as pamphlets, fact sheets, bulletins, newsletters, and telephone directories, as well as headquarters publications issued under the DOE-tr (DOE translation) and CONF (conference proceedings) codes, and technical reports from the Jet Propulsion Laboratory and NASA issued under DOE/JPL and DOE/NASA codes. The contents of this issue will not be repeated in subsequent issues of DOE/AD-0010. (RWR)

  9. 21st Century Community Learning Centers: Providing Afterschool and Summer Learning Support to Communities Nationwide

    Science.gov (United States)

    Afterschool Alliance, 2014

    2014-01-01

    The 21st Century Community Learning Centers (21st CCLC) initiative is the only federal funding source dedicated exclusively to before-school, afterschool, and summer learning programs. Each state education agency receives funds based on its share of Title I funding for low-income students at high-poverty, low performing schools. Funds are also…

  10. Developing a Personal-Learning-Portfolio (PLP) for 1st year students at Department of Psychology

    DEFF Research Database (Denmark)

    Johnsen, Anna Thit; Beck Hansen, Nina; Andersen, Mette Elmose

    Abstract title: Developing a Personal-Learning-Portfolio (PLP) for 1st year students at Department of Psychology Learning outcome of activity: B01 is the first module of the education in Psychology at University of Southern Denmark (SDU). The aim of B01 is to give the students a ‘map...... different strategies: first the overall framework of the PLP is discussed and second we conduct cognitive interviews evaluating the comprehensibility and relevance of the questions posed in the PLP. The PLP is then adapted based on the comments from the students. The development and initial testing...... be an inspiration to others who wish to develop and implements PLPs. Second, we will show the format of our particular Personal-Learning-Portfolio together with reflections on why it was developed in such a way. This includes the students’ opinions about the PLP and the results of the cognitive interviews....

  11. Selected DOE Headquarters publications, October 1979-

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-11-01

    This publication provides a cumulative listing of and an index to DOE headquarters publications issued since October 1979. (Publications issued during October 1977 to September 1979 are covered in DOE/AD-0010/6.) Three types of headquarters publications are included: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations, reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department, and environmental development plans, environmental impact statements, and environmental readiness documents. Certain publications have been omitted. They include such items as pamphlets, fact sheets, bulletins, newsletters, and telephone directories. Also omitted are weekly/monthly reports of the Energy Information Administration and headquarters publications issued under the DOE-tr and CONF codes. (RWR)

  12. Location - Managed Facility - St. Paul District (MVP)

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — St. Paul District - US Army Corps of Engineers Managed Facility locations. District headquarters, Natural Resource, Recreation, Lock and Dam, and Regulatory offices...

  13. DOE headquarters publications

    International Nuclear Information System (INIS)

    1978-12-01

    This bibliography provides listings of (mainly policy and programmatic) publications issued from the U.S. Department of Energy, Washington, D.C. The listings are arranged by the report number assigned to each publication. All of the publications listed, except for those shown as still in preparation, may be seen in the Energy Library. A title index arranged by title keywords follows the listings. Certain publications have been omitted. They include such items as pamphlets, fact sheets, bulletins and weekly/monthly issuances of DOE's Energy Information Administration and Economic Regulatory Administration, and employee bulletins and newsletters. Omitted from the bibliography altogether are headquarters publications assigned other types of report codes--e.g., HCP (Headquarters Contractor Publication) and CONF

  14. Legitimacy Dynamics in Headquarters-Subsidiary Relationships

    DEFF Research Database (Denmark)

    Gammelgaard, Jens; Kumar, Rajesh

    The relationship between multinational enterprises’ (MNE) headquarters and their subsidiaries has been of considerable interest to international business scholars (e.g., Dörrenbächer and Geppert, 2009). Although a subsidiary is an integral part of an MNE, its interests do not necessarily converge...... with those of headquarters. Many scholars note that relationships between headquarters and subsidiaries are characterized by the simultaneous presence of cooperation and competition (e.g., Bouquet and Birkinshaw, 2008; Otterbeck, 1981). On the one hand, the subsidiary and its managers are dependent...... on headquarters’ resources to fulfill its mandate. On the other hand, the subsidiary and its managers have their own particular goals, which may or may not coincide with the goals of headquarters and its managers. Subsidiary managers may also seek to develop the unit’s own sense of identity, which may...

  15. Selected DOE Headquarters Publications, October 1979

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-09-01

    This publication provides cumulative listings of and an index to DOE headquarters publications issued since October 1979. (Publications issued during October 1977-September 1979 are covered in DOE/AD-0010/6.) Three types of headquarters publications are included: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations, reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department, and environmental development plans and impact statements. Certain publications have been omitted. They include such items as pamphlets, fact sheets, bulletins, newsletters, and telephone directories, headquarters publications issued under the DOE-tr and CONF codes, technical reports from the Jet Propulsion Laboratory and NASA issued under DOE/JPL and DOE/NASA codes, and weekly/monthly reports of the Energy Information Administration. (RWR)

  16. Proceedings of the 1st LAK Data Challenge

    NARCIS (Netherlands)

    d'Aquin, Mathieu; Dietze, Stefan; Drachsler, Hendrik; Herder, Eelco; Taibi, Davide

    2013-01-01

    d'Aquin, M., Dietze, S., Drachsler, H., Herder, E., & Taibi, D. (Eds.) (2013, April). Proceedings of the 1st LAK Data Challenge, held at LAK 2013, the Third Conference on Learning Analytics and Knowledge. Published by CEUR Workshop Proceedings, 2013, Vol. 974.

  17. Team-based Learning Strategy in Biochemistry: Perceptions and Attitudes of Faculty and 1st-Year Medical Students.

    Science.gov (United States)

    Chhabra, Namrata; Kukreja, Sahiba; Chhabra, Sarah; Chhabra, Sahil; Khodabux, Sameenah; Sabane, Harshal

    2017-12-01

    Team-based learning (TBL) strategy has been widely adapted by medical schools all over the world, but the reports regarding the perceptions and the attitudes of faculty and undergraduate medical students towards TBL approach have been conflicting. The study aimed to introduce TBL strategy in curriculum of Biochemistry after evaluating its effectiveness through perceptions and attitudes of faculty and 1 st -year medical students. One hundred and fifty students of first professional M.B.B.S and five faculty members participated in the study. Their responses regarding perceptions and attitudes towards TBL strategy were collected using structured questionnaires, focus group discussions, and in-depth interviews. Data were analyzed using Wilcoxon signed-rank test, paired sample t -test, and Mann-Whitney U-test. Majority of the students expressed satisfaction with team approach and reported improvement in the academic scores, learning styles, and development of problem-solving, interpersonal, and professional skills. The faculty, however, recommended a modified TBL approach to benefit all sections of the students for the overall success of this intervention. TBL is an effective technique to enable the students to master the core concepts and develop professional and critical thinking skills; however, for the 1 st -year medical students, a modified TBL approach might be more appropriate for the effective outcomes.

  18. Selected DOE headquarters publications, October 1979

    International Nuclear Information System (INIS)

    1981-01-01

    The publication provides cumulative listings of and an index to DOE headquarters publications issued since October 1979. Publications issued during October 1977 to September 1979 are covered in DOE/AD-0010/6. Publications from 26 headquarters offices are presented and consist of three types: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations; reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department under 01-type contracts; and environmental development plans, impact statements, and readiness documents. Availability of the documents is described

  19. Selected DOE headquarters publications, October 1979

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-01-01

    The publication provides cumulative listings of and an index to DOE headquarters publications issued since October 1979. Publications issued during October 1977 to September 1979 are covered in DOE/AD-0010/6. Publications from 26 headquarters offices are presented and consist of three types: publications dealing mainly with program and policy that are attributed to and issued by headquarters organizations; reports prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department under 01-type contracts; and environmental development plans, impact statements, and readiness documents. Availability of the documents is described.

  20. Game based learning for 21st century transferable skills: challenges and opportunities

    NARCIS (Netherlands)

    Bellotti, Francesco; Bottino, Rosa Maria; Nadolski, Rob; Fernández Manjón, Baltasar

    2012-01-01

    Bellotti, F., Bottino, R. M., Nadolski, R. J., & Fernández Manjón, B. (2012, 4-6 July). Game based learning for 21st century transferable skills: challenges and opportunities. Presentation at the Workshop Game based learning for 21st century transferable skills: challenges and opportunities, 12th

  1. Longview District Operations and Maintenance Headquarters: Environmental assessment

    International Nuclear Information System (INIS)

    1992-03-01

    Bonneville Power Administration (BPA) operations and maintenance staff are presently based at a headquarters next to the Longview Substation. These headquarters buildings, however, were built in 1941 and have deteriorated to the point of needing extensive repair. They also lack sufficient inside storage space. New buildings cannot be constructed on the site because of surrounding development. In addition, the site is within an area exposed to industrial fallout (coal tar pitch and metallic particles) that may be damaging buildings, equipment, and vehicles. BPA is concerned about the potential health risk to headquarters staff from the fallout. In light of these problems, BPA proposes to construct a new operations and maintenance headquarters at a different location, and to demolish the existing headquarters. This paper discusses the environmental impacts of the proposed action and alternatives

  2. Headquarters Vienna

    International Nuclear Information System (INIS)

    1985-01-01

    This film presents the IAEA safeguards system showing six inspectors at their work in the nuclear power plants Kozloduy (Bulgaria), Mihama (Japan) as well as in the reprocessing plant La Hague (France). The results of inspections are checked at the IAEA Headquarters in Vienna. The film shows all modern techniques applied in the IAEA safeguards system

  3. Headquarters Vienna

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-12-31

    This film presents the IAEA safeguards system showing six inspectors at their work in the nuclear power plants Kozloduy (Bulgaria), Mihama (Japan) as well as in the reprocessing plant La Hague (France). The results of inspections are checked at the IAEA Headquarters in Vienna. The film shows all modern techniques applied in the IAEA safeguards system

  4. 39 CFR 223.2 - Channels of communication, headquarters with area offices.

    Science.gov (United States)

    2010-07-01

    ... RELATIONSHIPS AND COMMUNICATION CHANNELS § 223.2 Channels of communication, headquarters with area offices. (a... 39 Postal Service 1 2010-07-01 2010-07-01 false Channels of communication, headquarters with area...). Whether published on paper or online, such policies must be coordinated with other appropriate...

  5. Stimulating Sustainability in Multinational Companies: the Significance of Regional Headquarters

    Directory of Open Access Journals (Sweden)

    Andreas G. M. NACHBAGAUER

    2016-06-01

    Full Text Available Recently, regional headquarters have gained practical importance and theoretical attention. Traditionally considered a mere transmission facility to manage complex organisations, advanced approaches, however, locate regional headquarters in a field of tension between hierarchical integration and strategic independence. Given the growing concern for global responsibility, stimulating sustainability also and particularly addresses regional headquarters. This conceptual article combines the call for sustainability with the upcoming importance of regional headquarters: which contributions can the regional headquarters of a multinational company deliver to stimulate the development of sustainable corporate strategy and operations? The main topics are the effects different versions of embedding regional headquarters into the corporate context have on opportunities to implement sustainability policies: Are there different chances for successful implementation depending on the strategic setup of the company? Does the distribution of competences matter? Which types of interaction between headquarters and branch are suitable to introduce sustainability sustainably? Is the mix of national contexts of headquarters and branch of importance? First results show that depending on the companywide strategy, and especially on the structure and distribution of competences, regional headquarters can play a significant role as trigger of sustainability. The literature favours strong involvement and large autonomy of both branches as well as regional headquarters for the development and management of sustainability. The parts of the company involved in a critical environment often are the starting point of sustainability policies.

  6. 78 FR 13379 - Wrangell-St. Elias National Park and Preserve, Alaska; Proposed Mining Plan of Operations

    Science.gov (United States)

    2013-02-27

    ...] Wrangell-St. Elias National Park and Preserve, Alaska; Proposed Mining Plan of Operations AGENCY: National...) unpatented placer claims within Wrangell-St. Elias National Park and Preserve. Public Availability: This plan...: Wrangell-St. Elias National Park and Preserve Headquarters, Mile 106.8 Richardson Highway, Post Office Box...

  7. How do Regional Headquarters Influence Corporate Decisions in Networked MNCs?

    DEFF Research Database (Denmark)

    Mahnke, Volker; Ambos, Björn; Nell, Phillip Christopher

    2012-01-01

    In networked MNCs where knowledge and power are distributed, corporate strategy processes benefit from input arising from many different levels of the organization. Recently, the regional (i.e., supra-national) level has been emphasized as an important additional source of knowledge and input......, and as a bridge between local subsidiaries and global corporate headquarters. This paper builds theory on the antecedents to regional headquarters' influence on corporate decisions (i.e., organizational, behavioral, and motivational). Based on a survey of regional headquarters in Europe and their relations...... with MNC headquarters, we provide empirical evidence that a regional headquarters' autonomy and signaling behavior have significant effects on its influence on corporate strategy. Furthermore, we find support for our hypothesis that the regional headquarters' charter moderates such bottom–up influence....

  8. American Red Cross Headquarters

    Data.gov (United States)

    Department of Homeland Security — This point file represents only the headquarters location for each chapter and does not reflect any branch offices or warehouse facilities. Due to the recent changes...

  9. Environmental literacy with green chemistry oriented in 21st century learning

    Science.gov (United States)

    Mitarlis, Ibnu, Suhadi; Rahayu, Sri; Sutrisno

    2017-12-01

    The aim of this study is to analyze the design of chemistry subject with green chemistry oriented to improve students' environmental literacy as one of the important requirements of 21st century learning. This research used R&D design which consisted of four stages, i.e. preliminary study, the study of literature, development of materials, and expert and empirical validation. This article presents the results of preliminary study and the study of literature. It can be concluded from the results of an analysis that environmental literacy is one of the important components of learning outcomes which should be pursued in 21st century teaching. Philosophy of green chemistry plays an important role to reduce and prevent pollution of environment. Principles of green chemistry can be integrated into learning environment as learning outcomes or nurturant effects of learning.

  10. Fortune 500 Corporate Headquarters

    Data.gov (United States)

    Department of Homeland Security — Large Corporate Headquarters in the United States This database is composed of 'an annual list of the 500 largest industrial corporations in the U.S., published by...

  11. 1st IAEA research coordination meeting on tritium retention in fusion reactor plasma facing components. October 5-6, 1995, Vienna, Austria. Summary report

    International Nuclear Information System (INIS)

    Langley, R.A.

    1995-12-01

    The proceedings and results of the 1st IAEA research Coordination Meeting on ''Tritium Retention in Fusion Reactor Plasma Facing Components'' held on October 5 and 6, 1995 at the IAEA Headquarters in Vienna are briefly described. This report includes a summary of presentations made by the meeting participants, the results of a data survey and needs assessment for the retention, release and removal of tritium from plasma facing components, a summary of data evaluation, and recommendations regarding future work. (author). 4 tabs

  12. The missing dimension of knowledge transfer from subsidiaries to headquarters: The case of Oil and Gas companies in CEE region

    Directory of Open Access Journals (Sweden)

    Emil Velinov

    2016-12-01

    Full Text Available The paper identifies knowledge management determinants of knowledge transfer from subsidiaries to headquarters in the top Oil & Gas companies in Central and Eastern Europe as their level of innovations, internationalization and economic importance are emerging. The paper sheds a light not only on the process of knowledge transfer parent-subsidiary but via versa as it is critical in the 21st century for better adapting to specific business needs in certain geographical regions. Thus, this reversed knowledge from subsidiaries to headquarters is critical for the given business sector where the level of innovation and amount of R&D investments are enormous. The study argues that the reversed process of knowledge transfers from subsidiary to parent company is positively related to company performance and business diversification. Nowadays the knowledge formed in the subsidiaries of Multinational Corporations (MNCs is transferred to headquarters by investing in R&D centres, building new exploration and testing sites abroad. In the reversed knowledge transfer process we can identify main challenges, which are very critical to analyse and determine the exact process.

  13. Affinity Spaces and 21st Century Learning

    Science.gov (United States)

    Gee, James Paul

    2017-01-01

    This article discusses video games as "attractors" to "affinity spaces." It argues that affinity spaces are key sites today where people teach and learn 21st Century skills. While affinity spaces are proliferating on the Internet as interest-and-passion-driven sites devoted to a common set of endeavors, they are not new, just…

  14. Initial operations in local nuclear emergency response headquarter

    International Nuclear Information System (INIS)

    2012-06-01

    As a result of the Fukushima nuclear accident due to the Great East Japan Earthquake and the tsunami that occurred thereafter, local nuclear emergency response headquarters (local headquarters) was set up at off-site center (OFC). However, several obstacles such as the collapse of means of communication resulting from severed communication lines, food and fuel shortage resulting from stagnant physical distribution, and increasing radiation dose around the center significantly restricted originally intended operation of local headquarters. In such severe situation, the personnel gathered at the OFC from the government, local public bodies and electric companies from March 11 to 15 acted without sufficient food, sleep or rest and did all they could against successively occurring unexpected challenges by using limited means of communication. However, issues requiring further consideration were activities of each functional group, location of OFC and the functions of equipment, machines and materials and reflecting the consideration results into future protective measures and revision of the manual for nuclear emergency response were greatly important. This report described investigated results on initial operations in local headquarters such as situation of activities conducted by local headquarters and operations at functional groups. (T. Tanaka)

  15. Galileo Educational Network: Creating, Researching, and Supporting 21st Century Learning

    Science.gov (United States)

    Friesen, Sharon

    2009-01-01

    School and classroom structures designed to meet the needs of the industrial past cannot "maintain the temperature required for sustaining life." Recent learning sciences research findings compel educators to invent new learning environments better suited to meet the demands of the 21st century. These new learning environments require…

  16. Conflict Resolution in Headquarters-Subsidiary Relationships

    DEFF Research Database (Denmark)

    Kumar, Rajesh; Gammelgaard, Jens

    2016-01-01

    We demonstrate the role of regulatory fit and moral emotions, that is, contempt and anger, in influencing conflict resolution between the headquarters and subsidiary boundary spanners. We develop a theoretical framework, which integrates literature on international business and headquarters......-subsidiary relationships with regulatory focus, moral emotions, and conflict resolution. The chapter outlines the relationships between the regulatory focus of a headquarters’ boundary spanner, and his or her manner of engagement, conflict sensitivity, violation of code, moral emotions, and the way conflicts are resolved...

  17. USAFRICOM Headquarters: The Complexity of Moving the Headquarters to the Continent of Africa and its Impact on the Army’s Organizational Design and Operational Approach

    Science.gov (United States)

    2016-06-10

    partners: 1. Somalia–fighting piracy 2. South Africa–diplomatic relations 6 3. Liberia –fighting Ebola /UN mission 4. Nigeria–Boko Haram threat...offices to address issues on the continent.9 Liberia was one of the few countries 18 considered that welcomed the presence of a headquarters in their...only small countries like Liberia welcome a headquarters in Africa, while the larger countries do not welcome the idea. However, there has not been

  18. A learning skills course for the 1st year medical students: an experience at a Saudi medical school

    Directory of Open Access Journals (Sweden)

    Siddiqui IA

    2015-03-01

    Full Text Available Imran A Siddiqui,1 Khalid A Bin Abdulrahman,2 Mohammed A Alsultan3 1Department of Medical Education and Postgraduate Studies, Saudi Commission for Health Specialties, Riyadh, Saudi Arabia; 2College of Medicine, Al-Imam Muhammad Ibn Saud Islamic University (IMSIU, Riyadh, Saudi Arabia; 3College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia Background: Every year nearly 1,500 students enter into medical program after passing high school and national aptitude exams. However, many students experience frustration, failure, and psychological morbidities like stress, depression, and anxiety because they are not aware of their learning styles or do not have effective learning skills and strategies. The College of Medicine of Al-Imam Muhammad ibn Saud Islamic University has adopted the outcome based, community oriented, Spiral Curriculum. Although the curriculum is innovative, on the other hand, it is very demanding. Objective: The purpose of this paper is to share educational structure and evaluation results of the course on effective learning and study skills for the 1st year medical students. Methods: To prepare our students in order to cope with this demanding but promising curriculum, we conducted an effective and comprehensive learning skills course for 16 weeks in the first semester of year 1 in the medical program. Performance of each student was assessed and the course evaluation was done by students at the end of the course. Results: The attendance of the students throughout the course was over 90%. The average performance of students in the summative assessment was 78% and the course was generally liked by the students. Discussion: Students overall had a positive attitude toward the learning skills course. Majority of the students showed interest in attending the sessions regularly and realized the significance of this course to improve their learning skills. Keywords: medical students, learning

  19. 1st IAEA research co-ordination meeting on 'plasma-material interaction data for mixed plasma facing materials in fusion reactors'. Summary report

    International Nuclear Information System (INIS)

    Janev, R.K.; Longhurst, G.

    1998-12-01

    The proceedings and conclusions of the 1st IAEA Research Co-ordination Meeting on 'Plasma-Material Interaction Data for Mixed Plasma Facing Materials in Fusion Reactors', held on December 19 and 20, 1998 at the IAEA Headquarters in Vienna, are briefly described. This report includes a summary of the presentations made by meeting participants, a review of the data availability and data needs in the areas from the scope of the Co-ordinated Research Project (CRP) on the subject of the meeting, and recommendations regarding the future work within this CRP. (author)

  20. Directory - Social Media - The National Guard

    Science.gov (United States)

    Brigade 1st Battalion, 145th Armored Regiment Headquarters and Headquarters Company, 1st Battalion, 145th Florida Air National Guard Florida Guard History Camp Blanding Joint Training Center Wolfpack Company, 1st Force Georgia National Guard Joint Force Headquarters 116th Air Control Wing Flickr Georgia National

  1. Stimulating Sustainability in Multinational Companies: the Significance of Regional Headquarters

    OpenAIRE

    Andreas G. M. NACHBAGAUER

    2016-01-01

    Recently, regional headquarters have gained practical importance and theoretical attention. Traditionally considered a mere transmission facility to manage complex organisations, advanced approaches, however, locate regional headquarters in a field of tension between hierarchical integration and strategic independence. Given the growing concern for global responsibility, stimulating sustainability also and particularly addresses regional headquarters. This conceptual article combines the call...

  2. Selected DOE Headquarters publications received by the Energy Library

    International Nuclear Information System (INIS)

    1978-07-01

    This bibliography provides listings of (mainly policy and programmatic) publications issued from the U.S. Department of Energy, Washington, D.C. The listings are arranged by the ''report code'' assigned to the major organizations at DOE Headquarters, followed by the three categories of environmental reports issued from DOE Headquarters. All of the publications listed, except for those shown as still ''in preparation,'' may be seen in the Energy Library. A title index arranged by title keywords follows the listings. Certain publications have been omitted. They include such items as pamphlets, ''fact sheets,'' bulletins and weekly/monthly issuances of DOE's Energy Information Administration and Economic Regulatory Administration, and employee bulletins and newsletters. Omitted from the bibliography altogether are headquarters publications assigned other types of report codes--e.g., ''HCP'' (Headquarters Contractor Publication) and ''CONF''

  3. The Regional Special Operations Headquarters: Franchising the NATO Model as a Hedge in Lean Times

    Science.gov (United States)

    2012-04-01

    1 AIR FORCE FELLOWS AIR UNIVERSITY THE REGIONAL SPECIAL OPERATIONS HEADQUARTERS: FRANCHISING THE NATO MODEL AS A HEDGE IN LEAN...Headquarters: Franchising The NATO Model As A Hedge In Lean Times 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...it is not copyrighted, but is the property of the United States government. 3 The Regional Special Operations Headquarters: Franchising the

  4. Creating Research-Rich Learning Experiences and Quantitative Skills in a 1st Year Earth Systems Course

    Science.gov (United States)

    King, P. L.; Eggins, S.; Jones, S.

    2014-12-01

    We are creating a 1st year Earth Systems course at the Australian National University that is built around research-rich learning experiences and quantitative skills. The course has top students including ≤20% indigenous/foreign students; nonetheless, students' backgrounds in math and science vary considerably posing challenges for learning. We are addressing this issue and aiming to improve knowledge retention and deep learning by changing our teaching approach. In 2013-2014, we modified the weekly course structure to a 1hr lecture; a 2hr workshop with hands-on activities; a 2hr lab; an assessment piece covering all face-to-face activities; and a 1hr tutorial. Our new approach was aimed at: 1) building student confidence with data analysis and quantitative skills through increasingly difficult tasks in science, math, physics, chemistry, climate science and biology; 2) creating effective learning groups using name tags and a classroom with 8-person tiered tables; 3) requiring students to apply new knowledge to new situations in group activities, two 1-day field trips and assessment items; 4) using pre-lab and pre-workshop exercises to promote prior engagement with key concepts; 5) adding open-ended experiments to foster structured 'scientific play' or enquiry and creativity; and 6) aligning the assessment with the learning outcomes and ensuring that it contains authentic and challenging southern hemisphere problems. Students were asked to design their own ocean current experiment in the lab and we were astounded by their ingenuity: they simulated the ocean currents off Antarctica; varied water density to verify an equation; and examined the effect of wind and seafloor topography on currents. To evaluate changes in student learning, we conducted surveys in 2013 and 2014. In 2014, we found higher levels of student engagement with the course: >~80% attendance rates and >~70% satisfaction (20% neutral). The 2014 cohort felt that they were more competent in writing

  5. Are Large Headquarters Unproductive? Evidence from a Panel of Japanese Companies (Japanese)

    OpenAIRE

    MORIKAWA Masayuki

    2014-01-01

    This paper, using large panel data of Japanese companies (2001-2011), empirically analyzes the determinants of the size of headquarters and their effect on productivity. Headquarters functions, the core service sector within companies, play important roles in supporting strategic decision making in modern companies. However, it is often advocated that the downsizing of headquarters improves organizational efficiency. The size of headquarters is closely related to the issue of centralization/d...

  6. Enhancement of collaboration activities utilizing 21st century learning design rubric

    Science.gov (United States)

    Cubero, Dave D.; Gargar, Clare V., Lady; Nallano, Gerlett Grace D.; Magsayo, Joy R.; Guarin, Rica Mae B.; Lahoylahoy, Myrna E.

    2018-01-01

    Twenty first century learners have incredibly diverse learning interests, needs, and aspirations. Engaging middle school students and sculpting successful, confident, and creative learners is a constant endeavor for educators [4]. In the 21st century classroom environments in which students can develop the skills they need in workplace. Collaboration occurs when students work together to create, discuss challenge and develop deeper critical thinking. In today's workplace, collaboration is essential as only few tasks are completed alone (Calgary and Park, 2016). The collaborative project-based curriculum used in this classroom develops the higher order thinking skills, effective communication skills, and knowledge of technology that students will need in the 21st century workplace. The study therefore aims to promote collaboration skills among learners as it is deemed as one of the top 21st century skills. Collaborative learning unleashes a unique intellectual and social synergy. This study aims to enhance the collaborative skills of students through conducting collaboration activities in learning the Ecosystem. This research utilizes pretest-posttest and employs descriptive research designs. It uses modified activities about the lesson on Ecosystem and utilizes a Collaboration Rubric to rate the modified activities. The activities were rated by ten In-Service teachers and there are 105 students who participated in doing the activities. The paired t-test is then used to analyze the data. The In-Service teachers evaluated the 1st and 2nd adapted activity and are rated as fair. Thus, the modified activities were enhanced since the ratings of each activity did not meet the criterion of the collaboration rubric. As for the 3rd adapted activity is rated as excellent and is ready for implementation. The evaluators provided comments and suggestions such as producing colored pictures on the activities, omitting some questions, and making the words simpler to enhance the

  7. A Contextualized Model of Headquarters-subsidiary Agency Problems

    DEFF Research Database (Denmark)

    Kostova, Tatiana; Nell, Phillip Christopher; Hoenen, Anne Kristin

    This paper proposes an agency model for headquarters-subsidiary relationships in multinational organizations with headquarters as the principal and the subsidiary as the agent. As a departure from classical agency theory, our model is developed for the unit level of analysis and considers two root...... in which the headquarters-subsidiary dyad is embedded. We then discuss several agency scenarios that lead to different manifestations of the agency problem. The framework informs more relevant applications of agency theory in organizational studies and motivates future research....... causes of the agency problem – self-interest and bounded rationality. We argue that one cannot assume absolute self-interest and perfect rationality of agents but should allow them to vary. We explain subsidiary-level variation through a set of internal organizational and external social conditions...

  8. Earthquake: Game-based learning for 21st century STEM education

    Science.gov (United States)

    Perkins, Abigail Christine

    To play is to learn. A lack of empirical research within game-based learning literature, however, has hindered educational stakeholders to make informed decisions about game-based learning for 21st century STEM education. In this study, I modified a research and development (R&D) process to create a collaborative-competitive educational board game illuminating elements of earthquake engineering. I oriented instruction- and game-design principles around 21st century science education to adapt the R&D process to develop the educational game, Earthquake. As part of the R&D, I evaluated Earthquake for empirical evidence to support the claim that game-play results in student gains in critical thinking, scientific argumentation, metacognitive abilities, and earthquake engineering content knowledge. I developed Earthquake with the aid of eight focus groups with varying levels of expertise in science education research, teaching, administration, and game-design. After developing a functional prototype, I pilot-tested Earthquake with teacher-participants (n=14) who engaged in semi-structured interviews after their game-play. I analyzed teacher interviews with constant comparison methodology. I used teachers' comments and feedback from content knowledge experts to integrate game modifications, implementing results to improve Earthquake. I added player roles, simplified phrasing on cards, and produced an introductory video. I then administered the modified Earthquake game to two groups of high school student-participants (n = 6), who played twice. To seek evidence documenting support for my knowledge claim, I analyzed videotapes of students' game-play using a game-based learning checklist. My assessment of learning gains revealed increases in all categories of students' performance: critical thinking, metacognition, scientific argumentation, and earthquake engineering content knowledge acquisition. Players in both student-groups improved mostly in critical thinking, having

  9. The Influence of Transverse CSR Structure on Headquarters/Subsidiary Integration

    Directory of Open Access Journals (Sweden)

    Luciano Barin Cruz

    2010-07-01

    Full Text Available Some studies have already highlighted the effects of the introduction of Corporate Social Responsibility [CSR] projects into Multinational Corporations’ [MNC] strategies. However, little attention has been paid to the influence of transverse CSR structure on headquarters/subsidiary integration. In this article, we begin with the following question: What is the influence of the introduction of a centralized/decentralized structure on conducting a CSR strategy in a MNC? Our main objective is to identify conditions through which the structure of the CSR department influences the CSR strategy of the MNC. We define transverse CSR structure as: (1 the existence of a CSR directory at the headquarters level and a CSR representative at the subsidiary level, and (2 the existence of representatives from different areas who participate in meetings or committees to make decisions about CSR strategy. We argue that a transverse CSR structure favors consideration of global and local CSR demands by headquarters and subsidiaries. This process takes place through the mediation of three main elements: information exchange, awareness activities and definition of objectives.

  10. Elementary Science Instruction: Examining a Virtual Environment for Evidence of Learning, Engagement, and 21st Century Competencies

    Directory of Open Access Journals (Sweden)

    Terry K. Smith

    2014-03-01

    Full Text Available This mixed methods study examined the effectiveness of a virtual world curriculum for teaching elementary students complex science concepts and skills. Data were collected using pre- and post-content tests and a student survey of engaged learning, An additional survey collected teacher observations of 21st century competencies conducive to learning. The study involved a five-day intervention of fifteen 4th grade students in a small Midwestern school using a virtual science computer game from Arizona State University. Thirty elementary teachers from Australia, England, and the United States were surveyed on classroom observations of their elementary students working in the virtual world environment. Research questions guiding the virtual learning study were: (1 do pre- and post-content tests show significant learning in the virtual environment; (2 are students academically engaged during the learning process; and (3 are students actively demonstrating relevant 21st century competencies. The study supports prior research in game-based learning showing measureable learning results, highly engaged, motivated students, and observations of student behaviors conducive to learning science in school, namely collaboration, problem solving, critical thinking/inquiry, global awareness, and technology use.

  11. Science, technology, engineering, mathematics (STEM) as mathematics learning approach in 21st century

    Science.gov (United States)

    Milaturrahmah, Naila; Mardiyana, Pramudya, Ikrar

    2017-08-01

    This 21st century demands competent human resources in science, technology, engineering design and mathematics so that education is expected to integrate the four disciplines. This paper aims to describe the importance of STEM as mathematics learning approach in Indonesia in the 21st century. This paper uses a descriptive analysis research method, and the method reveals that STEM education growing in developed countries today can be a framework for innovation mathematics in Indonesia in the 21st century. STEM education integrate understanding of science, math skills, and the available technology with the ability to perform engineering design process. Implementation of mathematics learning with STEM approach makes graduates trained in using of mathematics knowledge that they have to create innovative products that are able to solve the problems that exist in society.

  12. Leveraging 21st Century Learning & Technology to Create Caring Diverse Classroom Cultures

    Science.gov (United States)

    Tarbutton, Tanya

    2018-01-01

    Creating diverse caring classroom environments, for all students, using innovative technology, is the impetus of this article. Administrators and teachers in many states have worked to integrate 21st Century Learning Outcomes and Local Control and Accountability Plans (LCAP) into daily teaching and learning. These initiatives are designed to…

  13. Are Large Headquarters Unproductive? Evidence from a panel of Japanese companies

    OpenAIRE

    MORIKAWA Masayuki

    2014-01-01

    Headquarters play an important role in modern companies, but the downsizing of headquarters is often advocated as a way to improve organizational efficiency. The size of headquarters is closely related to the centralization/decentralization of decision making, and a theoretically optimal level of (de)centralization depends on various conditions. Using a panel of more than 40,000 Japanese companies for the period 2001-2011, this paper empirically analyzes the determinants of the size of headqu...

  14. Developing Classroom Web Sites for 21st Century Learning

    Science.gov (United States)

    Tingen, Jennifer; Philbeck, Lauren; Holcomb, Lori B.

    2011-01-01

    Classroom Web sites have the potential to support and enhance student learning by targeting 21st century skills, such as collaboration among teachers, students, parents, and other teachers, media literacy, and interpersonal and self-directional skills, as well as thinking and problem-solving skills. Web 2.0 tools such as blogs, vokis, and podcasts…

  15. Designing blended learning interventions for the 21st century student.

    Science.gov (United States)

    Eagleton, Saramarie

    2017-06-01

    The learning requirements of diverse groups of students in higher education challenge educators to design learning interventions that meet the need of 21st century students. A model was developed to assist lecturers, especially those that are new to the profession, to use a blended approach to design meaningful learning interventions for physiology. The aim of the model is to encourage methodical development of learning interventions, while the purpose is to provide conceptual and communication tools that can be used to develop appropriate operational learning interventions. A whole brain approach that encourages challenging the four quadrants is encouraged. The main arguments of the model are to first determine the learning task requirements, as these will inform the design and development of learning interventions to facilitate learning and the assessment thereof. Delivery of the content is based on a blended approach. Copyright © 2017 the American Physiological Society.

  16. Remote Laboratory NetLab for Effective Teaching of 1st Year Engineering Students

    Directory of Open Access Journals (Sweden)

    Z. Nedic

    2007-08-01

    Full Text Available Practical skills are important attributes of every engineering graduate. The Internet has provided tertiary education with the opportunity to develop innovative learning environments. The teaching and learning of practical skills has gained a new dimension with the emergence of remote laboratories. The rapidly growing number of remote laboratories (RL worldwide is the evidence that the educational community has recognized their potential to develop into a creative, flexible, engaging, and student-cantered learning environment. Even a brief review of the existing RLs shows a large diversity in their structure, design and implementation. However, not many researchers disclose how their RLs are integrated within their curricula. Therefore, an important question still remains to be answered: how to optimize the design of RLs and their integration in a course curriculum for the best learning outcomes? This problem is particularly important when RLs are used in teaching 1st year students who have limited technical knowledge and practical experience in using real equipment. In this paper we would like to share our experiences with NetLab, an RL developed at the University of South Australia (UniSA for teaching 1st year engineering students and make recommendations for improvements in teaching practices based on it.

  17. Headquarters Of APSCO Opens In Beijing

    Institute of Scientific and Technical Information of China (English)

    Xu Yansong

    2009-01-01

    @@ The headquarters of Asia-Pacific Space Cooperation Organization (APSCO) has been inaugurated in Beijing.APSCO is the biggest space organization in Asia. Established in 2008, the organization has 9 members in the Asia-Pacific region.

  18. Mobile Devices: Toys or Learning Tools for the 21st Century Teenagers?

    Science.gov (United States)

    Kee, Ch'ng Lay; Samsudin, Zarina

    2014-01-01

    Learning is interwoven in daily life and so it can be take place at anytime and anywhere by using mobile device. In the 21st century, mobile devices have become ubiquitous, affordable and accessible for the teenagers. The teenagers have the opportunity to perform the learning activities by using the mobile devices. However, what are they used…

  19. ACRR fission product release tests: ST-1 and ST-2

    International Nuclear Information System (INIS)

    Allen, M.D.; Stockman, H.W.; Reil, K.O.; Grimley, A.J.; Camp, W.J.

    1988-01-01

    Two experiments (ST-1 and ST-2) have been performed in the Annular Core Research Reactor (ACRR) at Sandia National Laboratories (SNLA) to obtain time-resolved data on the release of fission products from irradiated fuels under light water reactor (LWR) severe accident conditions. Both experiments were conducted in a highly reducing environment at maximum fuel temperatures of greater than 2400 K. These experiments were designed specifically to investigate the effect of increased total pressure on fission product release; ST-1 was performed at approximately 0.16 MPa and ST-2 was run at 1.9 MPa, whereas other parameters were matched as closely as possible. Release rate data were measured for Cs, I, Ba, Sr, Eu, Te, and U. The release rates were higher than predicted by existing codes for Ba, Sr, Eu, and U. Te release was very low, but Te did not appear to be sequestered by the zircaloy cladding; it was evenly distributed in the fuel. In addition, in posttest analysis a unique fuel morphology (fuel swelling) was observed which may have enhanced fission product release, especially in the high pressure test (ST-2). These data are compared with analytical results from the CORSOR correlation and the VICTORIA computer model

  20. 77 FR 43864 - Solicitation for a Cooperative Agreement-Development of a 21st Century Corrections Learning...

    Science.gov (United States)

    2012-07-26

    ... levels of responsibility and job descriptions; (3) A narrative describing existing workplace learning...--Development of a 21st Century Corrections Learning Professional Competency Model AGENCY: National Institute of... Corrections Learning Professional Competency Model. This project will identify the workplace learning...

  1. Location trends of large company headquarters during the 1990s

    OpenAIRE

    Thomas H. Klier; William A. Testa

    2002-01-01

    This article documents changes in the spatial distribution of corporate headquarters of large U.S.-domiciled corporations during the 1990s. The authors find that the largest metropolitan areas continue to host a disproportionate share of headquarters, but there have been significant shifts toward cities with population between one and two million.

  2. 19 CFR 172.12 - Petitions acted on at Customs Headquarters.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Petitions acted on at Customs Headquarters. 172.12 Section 172.12 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Petitions § 172.12 Petitions acted on at Customs Headquarters. Upon receipt of a petition for relief filed...

  3. Bringing Foreign Language Learning into the 21st century | Thomas ...

    African Journals Online (AJOL)

    Bringing Foreign Language Learning into the 21st Century. The different challenges facing foreign language lecturers are considered as well as the different methods used to teach a foreign language. Technology and multimedia are proposed not only as tools and supports but also as a possible solution. With the change ...

  4. Iraqi Civil Defense Headquarters Baghdad, Iraq

    National Research Council Canada - National Science Library

    Johnston, Angelina; O'Connor, Kevin; Rawal, Yogin

    2007-01-01

    .... The assessment team included two engineers/inspectors and three auditors/inspectors. The overall objective of the project was to fully renovate the Civil Defense Headquarters and other buildings on the site to become a fully operational and usable facility.

  5. Identification and characterization of two novel cytosolic sulfotransferases, SULT1 ST7 and SULT1 ST8, from zebrafish

    Energy Technology Data Exchange (ETDEWEB)

    Liu, T.-A. [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan (China); Bhuiyan, Shakhawat [Division of Arts and Sciences, Jarvis Christian College, Hawkins, TX 75765 (United States); Snow, Rhodora [School of Mathematics and Science, J. Sargeant Reynolds Community College, Richmond, VA 23285 (United States); Yasuda, Shin; Yasuda, Tomoko [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Yang, Y.-S. [Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan (China); Williams, Frederick E.; Liu, M.-Y.; Suiko, Masahito [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Carter, Glendora [School of Mathematics and Science, J. Sargeant Reynolds Community College, Richmond, VA 23285 (United States); Liu, M.-C. [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States)], E-mail: ming.liu@utoledo.edu

    2008-08-29

    Cytosolic sulfotransferases (SULTs) constitute a family of Phase II detoxification enzymes that are involved in the protection against potentially harmful xenobiotics as well as the regulation and homeostasis of endogenous compounds. Compared with humans and rodents, the zebrafish serves as an excellent model for studying the role of SULTs in the detoxification of environmental pollutants including environmental estrogens. By searching the expressed sequence tag database, two zebrafish cDNAs encoding putative SULTs were identified. Sequence analysis indicated that these two putative zebrafish SULTs belong to the SULT1 gene family. The recombinant form of these two novel zebrafish SULTs, designated SULT1 ST7 and SULT1 ST8, were expressed using the pGEX-2TK glutathione S-transferase (GST) gene fusion system and purified from transformed BL21 (DE3) cells. Purified GST-fusion protein form of SULT1 ST7 and SULT1 ST8 exhibited strong sulfating activities toward environmental estrogens, particularly hydroxylated polychlorinated biphenyls (PCBs), among various endogenous and xenobiotic compounds tested as substrates. pH-dependence experiments showed that SULT1 ST7 and SULT1 ST8 displayed pH optima at 6.5 and 8.0, respectively. Kinetic parameters of the two enzymes in catalyzing the sulfation of catechin and chlorogenic acid as well as 3-chloro-4-biphenylol were determined. Developmental expression experiments revealed distinct patterns of expression of SULT1 ST7 and SULT1 ST8 during embryonic development and throughout the larval stage onto maturity.

  6. Modular Structures in a Multinational Force Headquarters

    National Research Council Canada - National Science Library

    Stewart, K; Christie, M

    2004-01-01

    .... It is proposed that future Multinational Force (MNF) military headquarters (HQ) can achieve this flexibility through a modular organizational structure enabled by networked information management and communication technologies...

  7. Orchestrating 21st Century Learning in Higher Education: A Perspective on Student Voice

    Science.gov (United States)

    Hämäläinen, Raija; Kiili, Carita; Smith, Blaine E.

    2017-01-01

    For universities to meet the 21st-century learning needs of today's students, it is important they allow students to take an active role in developing pedagogy and sharing their perspective. This paper introduces design-based research aiming to develop a pedagogic approach to support technology-enhanced learning practices at the university level…

  8. Three members of Medicago truncatula ST family are ubiquitous during development and modulated by nutritional status (MtST1) and dehydration (MtST2 and MtST3).

    Science.gov (United States)

    Albornos, Lucía; Martín, Ignacio; Labrador, Emilia; Dopico, Berta

    2017-07-10

    ShooT specific/Specific Tissue (ST) belong to a protein family of unknown function characterized by the DUF2775 domain and produced in specific taxonomic plant families, mainly Fabaceae and Asteraceae, with the Medicago truncatula ST family being the largest. The putative roles proposed for this family are cell elongation, biotic interactions, abiotic stress and N reserve. The aim of this work was to go deeper into the role of three M. truncatula ST proteins, namely ST1, ST2 and ST3. Our starting hypothesis was that each member of the family could perform a specific role, and hence, each ST gene would be subjected to a different type of regulation. The search for cis-acting regulatory elements (CREs) in silico in pST1, pST2 and pST3 promoters showed prevalence of tissue/organ specific motifs, especially root- and seed-specific ones. Light, hormone, biotic and abiotic related motifs were also present. None of these pSTs showed the same combination of CREs, or presented the same activity pattern. In general, pST activity was associated with the vascular cylinder, mainly in roots. Promoter activation was highly specific and dissimilar during reproductive development. The ST1, ST2 and ST3 transcripts accumulated in most of the organs and developmental stages analysed - decreasing with age - and expression was higher in the roots than in the aerial parts and more abundant in light-grown plants. The effect of the different treatments on transcript accumulation indicated that ST1 behaved differently from ST2 and ST3, mainly in response to several hormones and dehydration treatments (NaCl or mannitol), upon which ST1 transcript levels decreased and ST2 and ST3 levels increased. Finally, the ST1 protein was located in the cell wall whereas ST2 and ST3 were present both in the cytoplasm and in the cell wall. The ST proteins studied are ubiquitous proteins that could perform distinct/complementary roles in plant biology as they are encoded by differentially regulated genes

  9. The Size and Composition of Corporate Headquarters in Multinational Companies: Empirical Evidence

    OpenAIRE

    Collis, David J.; Young, David; Goold, Michael

    2012-01-01

    Based on a six-country survey of nearly 250 multinationals (MNCs), this paper is the first empirical analysis to describe the size and composition of MNC headquarters and to account for differences among them. Findings are as follows: MNC corporate headquarters are more involved in "obligatory" and value creating and control functions than in operational activities; there are no systematic differences in the determinants of the size and composition of corporate headquarters between MNCs and p...

  10. Constructing Learning-by-Doing Pedagogical Model for Delivering 21st Century Engineering Education

    Directory of Open Access Journals (Sweden)

    Ghassan Frache

    2018-01-01

    Full Text Available The United Arab Emirates (UAE is dedicated to establishing the best teaching and learning environment for students and staff across all higher education institutions. To heed this call, the engineering division adopted the Learning-by-Doing (LBD pedagogical philosophy for 21st Century education at the heart of its strategic directions. This study intends to explore how LBD is understood and practiced in UAE colleges and how 21st Century skills can be explicitly incorporated into its engineering curriculum by using constructive alignment as a pattern for instructional design. This work intends to investigate the general question: “What constructively aligned Learning-by-Doing pedagogical model, with the incorporation of 21st Century skills, needs to be developed to effectively teach and prepare engineering students at the Higher College of Technology, UAE for successful long-term employment in the global working economy?”. Using mixed method research design and input from its major stakeholders, student survey questionnaires, engineering instructors and dean structured interviews, overt class observation and syllabi examination have all been utilized for data triangulation. In conclusion, the study developed a collaborative LBD model tailor-fitted to the institution’s engineering program and to UAE’s culture.

  11. Developing 21st century skills through the use of student personal learning networks

    Science.gov (United States)

    Miller, Robert D.

    This research was conducted to study the development of 21st century communication, collaboration, and digital literacy skills of students at the high school level through the use of online social network tools. The importance of this study was based on evidence high school and college students are not graduating with the requisite skills of communication, collaboration, and digital literacy skills yet employers see these skills important to the success of their employees. The challenge addressed through this study was how high schools can integrate social network tools into traditional learning environments to foster the development of these 21st century skills. A qualitative research study was completed through the use of case study. One high school class in a suburban high performing town in Connecticut was selected as the research site and the sample population of eleven student participants engaged in two sets of interviews and learned through the use social network tools for one semester of the school year. The primary social network tools used were Facebook, Diigo, Google Sites, Google Docs, and Twitter. The data collected and analyzed partially supported the transfer of the theory of connectivism at the high school level. The students actively engaged in collaborative learning and research. Key results indicated a heightened engagement in learning, the development of collaborative learning and research skills, and a greater understanding of how to use social network tools for effective public communication. The use of social network tools with high school students was a positive experience that led to an increased awareness of the students as to the benefits social network tools have as a learning tool. The data supported the continued use of social network tools to develop 21st century communication, collaboration, and digital literacy skills. Future research in this area may explore emerging social network tools as well as the long term impact these tools

  12. Headquarters-subsidiary relationship governance in Poland

    NARCIS (Netherlands)

    Gusc, J.S.; Omta, S.W.F.

    2011-01-01

    The study addresses the views of agency and stewardship theory on governance of the relationship between headquarters and subsidiaries. It explores the influence of strategy, task environment and cultural differences on this relationship. The conceptual model is explored based on a survey of 76

  13. MNC Headquarters as Global Network Orchestrators

    DEFF Research Database (Denmark)

    Valentino, Alfredo; Nell, Phillip Christopher; Hotho, Jasper J.

    2014-01-01

    Despite increased interest in headquarters (HQ) and their activities, we still lack a comprehensive understanding of the drivers of HQ relocations and their consequences. We seek to address this gap by examining whether HQ relocations are primarily driven by cost-reduction or value-creation motiv...

  14. Smart Social Networking: 21st Century Teaching and Learning Skills

    Directory of Open Access Journals (Sweden)

    Helen B. Boholano

    2017-06-01

    Full Text Available Education in the 21st century highlights globalization and internationalization. Preservice teachers in the 21st century are technology savvy. To effectively engage and teach generation Z students, preservice teachers will help the educational system meet this requirement. The educational systems must be outfitted with a prerequisite of ICT resources both hardware and software, and curricula must be designed to promote a collaborative learner-centered environment to which students will relate and respond. This study determines the 21st century skills possessed by the pre-service teachers in terms of social networking. Pre-service teachers use computers in very advanced ways, but educators must remember that they still need guidance to use technology safely and effectively. Through social media the pre-service teachers can use a multitude of applications, including Web 2.0, for their projects. Smart social networking requires critical-thinking skills and the ability to integrate and evaluate real-world scenarios and authentic learning skills for validation.

  15. New management structure at headquarters

    Science.gov (United States)

    On July 1, 1987, AGU Executive Director Fred Spilhaus informed the AGU staff that Judy C. Holoviak has been promoted to the position of Group Director. This is a new management position with responsibility for more than one division. Both the Publications Division and the newly formed Public Information and Marketing Division will report to Holoviak, as will the new Special Assistant for Nonprint Publications.Spilhaus explained that this new position will permit the headquarters management staff to be responsive to the current AGU growth. A stronger management structure is needed to take advantage of the many opportunities facing the Union. In pointing to the initiatives identified by the Planning Committee, he stated that continued growth is the only likely course for AGU.

  16. Understanding Agency Problems in Headquarters-Subsidiary Relationships in Multinational Corporations

    DEFF Research Database (Denmark)

    Kostova, Tatiana; Nell, Phillip Christopher; Hoenen, Anne Kristin

    2016-01-01

    This paper proposes an agency model for headquarters-subsidiary relationships in multinational organizations with headquarters as the principal and the subsidiary as the agent. As a departure from classical agency theory, our model is developed for the unit level of analysis and considers two root...... causes of the agency problem—self-interest and bounded rationality. We argue that in the organizational setting, one cannot assume absolute self-interest and perfect rationality of agents (subsidiaries) but should allow them to vary. We explain subsidiary-level variation through a set of internal...... organizational and external social conditions in which the headquarters-subsidiary agency dyad is embedded. We then discuss several agency scenarios reflecting various levels of self-interest and rationality that lead to different manifestations of the agency problem. The proposed framework can inform more...

  17. Cutting Fat or Removing the Brain: Is the Divisional ADA Battalion Headquarters Necessary?

    National Research Council Canada - National Science Library

    Sauter, Daniel

    1998-01-01

    .... This monograph examines whether the divisional ADA battalion headquarters, an intermediate headquarters, is necessary to command and control divisional air defense operations in a Force XXI environment...

  18. Key Management Theories ... and What They Have to Say with Regards to Contemporary Headquarters Structures

    DEFF Research Database (Denmark)

    Nell, Phillip Christopher

    2018-01-01

    Multinational and multibusiness headquarters increasingly structure their headquarters in novel ways. They use several locations spread around the world, differentiate different types of headquarters activities in a very fine-grained way, they temporarily relocate top management teams, or relocate...

  19. 76 FR 19467 - Weyerhaeuser Company, Corporate Headquarters Including On-Site Leased Workers From Volt Services...

    Science.gov (United States)

    2011-04-07

    ... employed on-site at the Federal Way, Washington location of Weyerhaeuser Company, Corporate Headquarters... Company, Corporate Headquarters to be considered leased workers. Based on these findings, the Department... Federal Way, Washington location of Weyerhaeuser Company, Corporate Headquarters. The amended notice...

  20. 75 FR 76040 - Weyerhaeuser Company Corporate Headquarters Including On-Site Leased Workers From Volt Services...

    Science.gov (United States)

    2010-12-07

    ... Assistance on June 2, 2010, applicable to workers of Weyerhaeuser Company, Corporate Headquarters, including... Weyerhaeuser Company, Corporate Headquarters to be considered leased workers. Based on these findings, the... the Federal Way, Washington location of Weyerhaeuser Company, Corporate Headquarters. The amended...

  1. Eastman Kodak Company: 21st Century Learning Challenge. Volunteer Resource Manual.

    Science.gov (United States)

    Strother, Wanda M.; And Others

    The Kodak 21st Century Learning Challenge is a companywide, 10-year corporate commitment to improve mathematics, science, and technology achievement for all students in the communities around Kodak's manufacturing plants. The Rochester (New York) initiative for which this training manual is presented is a partnership among Kodak, the Rochester…

  2. When salespeople develop negative headquarters stereotypes: performance effects and managerial remedies

    OpenAIRE

    Homburg, Christian; Wieseke, Jan; Lukas, Bryan A.; Mikolon, Sven

    2011-01-01

    This study examines the performance implications that organizations may suffer when their salespeople develop negative stereotypes of their corporate headquarters. How such stereotypes can be remedied through managerial action is also examined. The study draws on matched data from four different sources: sales managers, salespeople, customers, and company reports. Findings indicate that negative headquarters stereotypes among salespeople are associated with poor marketing-related ...

  3. Higher Order Thinking Skills as Effect of Problem Based Learning in the 21st Century Learning

    Directory of Open Access Journals (Sweden)

    Leni Widiawati

    2018-03-01

    Full Text Available This study aims to determine the responses of learners to learning using a scientific approach in Problem Based Learning integrated with the inculcation of critical thinking, communicative, collaboration; and creative (4C skills in 21st century learning. The design of this study is true experiment by using posttest only control design. The sample of the research is vocational school students selected by using cluster random sampling technique in Surakarta, Indonesia. The techniques of collecting data are using tests whose validity, reliability, level of difficulty, and the discrimination index have been tested. The data obtained are then tested using t test. The result of the research shows that higher order thinking skills of experimental class students learning using scientific approach in Problem Based Learning which is integrated with the inculcation of 4C skills are higher than those of the control class that are learning using scientific approach in Think-Pair-Share which is integrated with the inculcation of 4C skills.

  4. 78 FR 52982 - Experian, Experian US Headquarters: Corporate Departments (Finance, HRMD, Contracts, Corporate...

    Science.gov (United States)

    2013-08-27

    ...,506R] Experian, Experian US Headquarters: Corporate Departments (Finance, HRMD, Contracts, Corporate... Headquarters: Corporate Departments (finance, HRMD, Contracts, Corporate Marketing, Global Corporate Systems... (finance, HRMD, Contracts, Corporate Marketing, Global Corporate Systems, Legal & Regulatory, Risk...

  5. Innovative building automation concept for Pumavision Headquarters. Where Pimas are feeling well; Innovatives Gebaeudeautomationskonzept fuer Pumavision Headquarters. Wo Pumas sich wohl fuehlen sollen

    Energy Technology Data Exchange (ETDEWEB)

    Habermann, Ralf [IPM Gebaeudeleittechnik GmbH, Feucht bei Nuernberg (Germany); Kerz, Thomas [Siemens-Div. Building Technologies Deutschland, Frankfurt am Main (Germany). Business Unit CPS; Vogel, Helmut [Siemens-Div. Building Technologies Deutschland, Muenchen (Germany). Business Unit CPS Region Bayern

    2011-03-15

    The sport's and lifestyle company PUMA (Herzogenaurach, Federal Republic of Germany) claims the establishment of the first climate neutral corporate headquarter of its industry. Therefore, the electricity for the new 35,000 m{sup 2} large corporate headquarters exclusively results from renewable energy sources. The conversion of this goal is supported by the interdisciplinary building automation system Desigo from Siemens AG (Munich, Federal Republic of Germany). The basic heating and basic cooling of the main building are performed by a concrete core tempering. A part of the heating and cooling is produced by means of two heat pumps.

  6. Closing the 21st-Century Knowledge Gap: Reconceptualizing Teaching and Learning to Transform Business Education

    Science.gov (United States)

    Longmore, Anne-Liisa; Grant, Ginger; Golnaraghi, Golnaz

    2018-01-01

    The 21st century is seeing dramatic shifts in the business environment. In order for organizations to adapt to these shifts, they must be more flexible and learning oriented. To thrive in this environment, organizational leaders must facilitate and build the capacity for learning throughout the organization. Organizational leadership is looking…

  7. An analysis of headquarters location in the Canadian oil and gas sector

    International Nuclear Information System (INIS)

    Hirsch, K.T.

    1993-04-01

    Headquarters location theory identifies several factors which are expected to influence the location of corporate head offices. Some of these factors directly affect the costs of operation and the basic profitability of the company, such as the cost of office space, tax levels, availability of qualified labour, cost of labour, proximity to corporate activities, and agglomeration with other services and companies. Headquarters location theory is applied to Canada's energy sector. During the previous 27 years, concentration of energy company headquarters has shifted from Toronto to Calgary. A regression model tests the extent to which those factors identified in the literature appear to be statistically significant for the headquarters relocation experience in Canada's energy sector. The results of the tests suggest that certain factors do appear to significantly influence relocation decisions. These factors are agglomeration with other oil and gas companies, and relative proximity to oil and gas operations (which unexpectedly displayed a negative coefficient). The agglomeration factor was by far the most significant. 44 refs., 3 figs., 2 tabs

  8. Mindful Strengths Development: Leveraging Students' Strengths for 21st Century Learning and Leadership

    Science.gov (United States)

    Tanious, Christy M.

    2012-01-01

    The continuous change characterizing 21st century society has significant implications for higher education. Educators and business leaders increasingly recognize that education within and preparation for a context of change requires learning environments fostering openness, flexibility, and engagement with other ideas and people. Such…

  9. Gamification: Questing to Integrate Content Knowledge, Literacy, and 21st-Century Learning

    Science.gov (United States)

    Kingsley, Tara L.; Grabner-Hagen, Melissa M.

    2015-01-01

    This article showcases the use of gamification as a means to turn an existing curriculum into a game-based learning environment. The purpose of this article is to examine how gamification, coupled with effective pedagogy, can support the acquisition of 21st-century skills. Gamifying content allows students to earn experience points, badges, and…

  10. Writing Our Way: Giving Voice to Adult Learning. Adult Higher Education Alliance Annual Conference Proceedings (41st, Orlando, Florida, March 9-10, 2017)

    Science.gov (United States)

    Elufiede, Kemi, Ed.; Flynn, Bonnie, Ed.; Olson, Joann S., Ed.

    2017-01-01

    The 41st annual conference of the Adult and Higher Education Alliance (AHEA) was held at the University of Central Florida in March 2017 and explored the theme, "Writing Our Way: Giving Voice to Adult Learning." Papers in these proceedings include: (1) Transformative Learning Following Job Loss-A Dissertation Renewal (Robert Benway); (2)…

  11. Physical fitness and health education program at NASA Headquarters

    Science.gov (United States)

    Angotti, Cathy

    1993-01-01

    The topics discussed include the following: policy procedures to enter the NASA Headquarters Physical Fitness and Health Program; eligibility; TDY eligibility; health promotions offered; and general facility management.

  12. Evaluation of screening for oral cancer and precancer in a company headquarters.

    Science.gov (United States)

    Downer, M C; Evans, A W; Hughes Hallet, C M; Jullien, J A; Speight, P M; Zakrzewska, J M

    1995-04-01

    Oral cancer and precancer appear to fulfil many of the criteria for a disease suitable for mass screening. Several commercial organisations in the UK have introduced screening for their employees. One program has been formally evaluated over the course of 1 yr. Of 553 company headquarters staff aged > or = 40 yr, 292 (53%) responded to the well-publicised screening invitation and received a simple clinical examination of the oral mucosa from one of two company dentists. In addition, 17 staff were screened from a separate company work-site. After screening, subjects were examined independently by an oral medicine specialist with access to the relevant diagnostic aids. The dentists' screening decisions were validated against the specialist's definitive diagnoses (the 'gold standard'). The true prevalence of subjects with lesions diagnosed as positive (white patch, red patch or ulcer of greater than 2 weeks' duration) was 17 (5.5%). Overall, sensitivity was 0.71 and specificity, 0.99. The compliance rate to screening among headquarters subjects in seven occupational categories did not differ significantly from the occupational profile for all headquarters personnel. Estimates of relative risk of a positive diagnosis were calculated by logistic regression for five independent variables; gender, age, moderate smoking, heavy smoking, and smoking combined with greater than low risk alcohol consumption. Only heavy smoking (> or = 20 cigarettes per day) produced a significant odds ratio (3.43, P < 0.05).

  13. Exploring the Potential Impact of Serious Games on Social Learning and Stakeholder Collaborations for Transboundary Watershed Management of the St. Lawrence River Basin

    Directory of Open Access Journals (Sweden)

    Wietske Medema

    2016-04-01

    Full Text Available The meaningful participation of stakeholders in decision-making is now widely recognized as a crucial element of effective water resource management, particularly with regards to adapting to climate and environmental change. Social learning is increasingly being cited as an important component of engagement if meaningful participation is to be achieved. The exact definition of social learning is still a matter under debate, but is taken to be a process in which individuals experience a change in understanding that is brought about by social interaction. Social learning has been identified as particularly important in transboundary contexts, where it is necessary to reframe problems from a local to a basin-wide perspective. In this study, social learning is explored in the context of transboundary water resource management in the St. Lawrence River Basin. The overarching goal of this paper is to explore the potential role of serious games to improve social learning in the St. Lawrence River. To achieve this end, a two-pronged approach is followed: (1 Assessing whether social learning is currently occurring and identifying what the barriers to social learning are through interviews with the region’s water resource managers; (2 Undertaking a literature review to understand the mechanisms through which serious games enhance social learning to understand which barriers serious games can break down. Interview questions were designed to explore the relevance of social learning in the St. Lawrence River basin context, and to identify the practices currently employed that impact on social learning. While examples of social learning that is occurring have been identified, preliminary results suggest that these examples are exceptions rather than the rule, and that on the whole, social learning is not occurring to its full potential. The literature review of serious games offers an assessment of such collaborative mechanisms in terms of design principles

  14. Corporate headquarters as physical embodiments of organisational change

    NARCIS (Netherlands)

    van Marrewijk, A.H.

    2009-01-01

    Purpose: The purpose of this paper is to explore the interdependency of corporate architecture and organisation cultural change. Corporate headquarters have become symbols of corporate change ambitions to endure cultural value sets. The paper seeks to contribute to the growing interest in the

  15. Development strategies for science learning management to transition in the 21st century of Thailand 4.0

    Science.gov (United States)

    Jedaman, Pornchai; Buraphan, Khajornsak; Yuenyong, Chokchai; Suksup, Charoen; Kraisriwattana, Benchalax

    2018-01-01

    Science learning management aims to analyze the development strategies for science learning management to transition in the 21st Century of Thailand 4.0. Is qualitative study employed review of documentary, questionnaire both to the participatory action learning with the teachers intwenty-five Secondary education area offices in the basic education of Thailand. The participants were cluster sampling random of each 150 persons. Data analysis includes data reduction, data organization, data interpretation to conclusion. The main of this study were to a creating innovation, links and access to technology as well as to the changes. It is very important for needs to be learning management for effective of science subject in the educational. Led to the plan to driven for the science learning management were a success in the 21st century, spanning strategy were converted of practical the steps throughinstitutional research and development to solve problems in changing identity, reorientation, paradigm shifted, transformation of cultural to propel the country for first world Nation in the elements were "6R12C3E".

  16. When Do Distance Effects Become Empirically Observable? An Investigation in the Context of Headquarters Value Creation for Subsidiaries

    OpenAIRE

    Beugelsdijk, Sjoerd; Nell, Phillip C.; Ambos, Björn

    2017-01-01

    Integrating distance research with the behavioral strategy literature on MNC headquarters-subsidiary relations, this paper explores how the distance between headquarters and subsidiaries relates to value added by the headquarters. We show for 124 manufacturing subsidiaries in Europe that, on average, distance is unrelated to value added by headquarters but that this effect is contingent upon the extent to which the subsidiary is locally embedded. Only after a certain threshold level of subsid...

  17. When Do Distance Effects Become Empirically Observable? An Investigation in the Context of Headquarters Value Creation for Subsidiaries

    NARCIS (Netherlands)

    Beugelsdijk, Sjoerd; Nell, Phillip C.; Ambosd, Bjoern

    Integrating distance research with the behavioral strategy literature on MNC headquarters-subsidiary relations, this paper explores how the distance between headquarters and subsidiaries relates to value added by the headquarters. We show for 124 manufacturing subsidiaries in Europe that, on

  18. local government headquarters and spatial interaction within rivers

    African Journals Online (AJOL)

    user

    headquarters and rural hinterland settlements in Rivers South East ... of Rivers State is responsible for over seventy percent (70%) of the total employment in the ... even proportion and balanced development for all could not completely ... Rivers West ... agricultural under development, unemployment, poor quality of life due.

  19. The Effect of a Stimulating Learning Environment on Pre-Service Teachers' Motivation and 21st Century Skills

    Science.gov (United States)

    Nissim, Yonit; Weissblueth, Eyal; Scott-Webber, Lennie; Amar, Shimon

    2016-01-01

    We investigated the effect of an innovative technology-supported learning environment on pre-service student teachers' motivation and 21st century skills. Students and instructors filled-in the Active Learning Post Occupancy Evaluation (AL-POE) questionnaire. Analysis included tests for individual items and a comparison of the overall mean,…

  20. Teaching and Learning Jewish History in the 21st Century: New Priorities and Opportunities

    Science.gov (United States)

    Jacobs, Benjamin M.

    2018-01-01

    New 21st-century circumstances in the Jewish world--including the changing nature of Jewish identification, the retreat from identity and continuity as singular aims of Jewish education, the democratization of Jewish learning opportunities, increased emphasis on informal and experiential Jewish education activities, and demonstrable interest among…

  1. A global learning-centered approach to higher education: workplace development in the 21st century

    Directory of Open Access Journals (Sweden)

    Carlos Tasso Eira de Aquino

    2017-01-01

    Full Text Available Competition in the 21st century economy requires corporations, organizations, and professionals to face a common challenge: diverse individuals need consistent motivation towards building competences that increase personal marketability using a combination of higher education and professional development. This article represents an evolving report summary and non-traditional learning-centered approach focusing on adult competences necessary for succeeding in the competitive global marketplace of the 21st century. The purpose of this article is to understand the needs of constantly changing employer demands in the work environment. Exploring contemporary approaches related to skill development, adult education, and learning processes, will be the path towards higher levels of professional success. This article will provide readers with an enlightening discussion focusing on the necessary adult skills and competencies professionals need to succeed in the global marketplace.

  2. From Digital Natives to Digital Wisdom: Hopeful Essays for 21st Century Learning

    Science.gov (United States)

    Prensky, Marc

    2012-01-01

    What can you learn on a cell phone? Almost anything! How does that concept fit with our traditional system of education? It doesn't. Best-selling author and futurist Marc Prensky's book of essays challenges educators to "reboot" and make the changes necessary to prepare students for 21st century careers. His "bottom-up" vision is based on…

  3. Learner Dashboards a Double-Edged Sword? Students' Sense-Making of a Collaborative Critical Reading and Learning Analytics Environment for Fostering 21st-Century Literacies

    Science.gov (United States)

    Pei-Ling Tan, Jennifer; Koh, Elizabeth; Jonathan, Christin; Yang, Simon

    2017-01-01

    The affordances of learning analytics (LA) tools and solutions are being increasingly harnessed for enhancing 21st century pedagogical and learning strategies and outcomes. However, use cases and empirical understandings of students' experiences with LA tools and environments aimed at fostering 21st century literacies, especially in the K-12…

  4. CDC WONDER: Population - Bridged-Race July 1st Estimates

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Population - Bridged-Race July 1st Estimates online databases report bridged-race population estimates of the July 1st resident population of the United States,...

  5. Managing Market Segmentatıon for Dıfferent Brands of the same Headquarter

    Directory of Open Access Journals (Sweden)

    Ahmet Hakan Özkan

    2016-10-01

    Full Text Available Brand management is inevitable for sustainable marketing. Civil aviation companies focus on sustainable marketing, because of their long-term investments. Customer loyalty is one of the most improtant factors of sustainable marketing. It is known that, if there is no certain limit or border, segmentation damages the reputation of the brands and it is one of the most important threats of sustainable marketing. Segmentation can be done by using new brands, but this process has its own constraints. Such constraints are related with the reputability of the company. To evaluate the impact of a new brand on reputability, service quality is taken as a metric and SERVQUAL is used. The customers of two civil aviation companies participated the study. These two aviation companies have the same headquarter, but they have different brand management strategies. One of them is globally reputable and it is the headquarter company. 166 questionnaires of the 83 participants are evaluated. It is seen that the service quality perception on the brand of the headquarter company did not change and the new brand did not effect its reputability. New brand created its own market or took a share from the other civil aviation companies which attract the customers of the headquarter company with their lower prices.

  6. Social Aesthetics in Learning Practices in the 21st Century

    DEFF Research Database (Denmark)

    Buhl, Mie; Ejsing-Duun, Stine

    Social Aesthetics in Learning Practices in the 21st Century Due to the extensive reliance on media in our everyday perception of the surroundings we see a shift in relation to aesthetics from an individual focus to social negotiations around a situation. This article presents how individuals shape......, both, theoretically and through an explorative study: Theoretically we draw from visual culture (Buhl, 2012;Bourriaud, 2002; Mitchell, 2002), learning (Dohn, 2002) and digital media studies (Ejsing-Duun, 2011). The explorative case study is focused on the use of the mobile application Draw Something...... (Buhl and Ejsing-Duun, 2013), along with other current apps. In a case study we take them as examples of how technology facilitates our meeting with the world though the senses and how we decode and negotiate social aesthetic expressions. The intent of the article is to suggest and discuss an aesthetic...

  7. Problem-based learning: a strategic learning system design for the education of healthcare professionals in the 21st century.

    Science.gov (United States)

    Gwee, Matthew Choon-Eng

    2009-05-01

    -making process. Implementation of PBL can be a daunting task and will require detailed and careful planning, together with a significant commitment on the part of educators given the responsibility to implement PBL in an institution. PBL can offer a more holistic, value-added, and quality education to energize student learning in the healthcare professions in the 21st century. Successful implementation of PBL can therefore help to nurture in students the development of desired "habits of mind, behavior, and action" to become the competent, caring, and ethical healthcare professionals of the 21st century. Thus, PBL can contribute to the improvement of the healthcare of a nation by healthcare professionals, but we need to do it right.

  8. Draft Genome Sequences of Staphylococcus aureus AMRF1 (ST22) and AMRF2 (ST672), Ocular Methicillin-Resistant Isolates

    KAUST Repository

    Velusamy, Nithya

    2014-03-20

    Sequence type 22 (ST22) and ST672 are the two major emerging clones of community-acquired methicillin-resistant Staphylococcus aureus in India. ST672 strains were found to cause severe ocular infections. We report the draft genome sequences of two emerging strains of methicillin-resistant S. aureus, AMRF1 (ST22) and AMRF2 (ST672), isolated from patients with ocular infections.

  9. Draft Genome Sequences of Staphylococcus aureus AMRF1 (ST22) and AMRF2 (ST672), Ocular Methicillin-Resistant Isolates

    KAUST Repository

    Velusamy, Nithya; Prakash, Logambiga; Neelamegam, Sivakumar; Antony, Aju; Prajna, Lalitha; Mohankumar, Vidyarani; Devarajan, Bharanidharan

    2014-01-01

    Sequence type 22 (ST22) and ST672 are the two major emerging clones of community-acquired methicillin-resistant Staphylococcus aureus in India. ST672 strains were found to cause severe ocular infections. We report the draft genome sequences of two emerging strains of methicillin-resistant S. aureus, AMRF1 (ST22) and AMRF2 (ST672), isolated from patients with ocular infections.

  10. The Effectiveness of Traditional and 21st Century Teaching Tools on Students' Science Learning

    Science.gov (United States)

    Bellflower, Julie V.

    Any student seeking a high school diploma from the public school system in one U.S. state must pass the state's high school graduation test. In 2009, only 88% of students at one high school in the state met the basic proficiency requirements on the science portion of the test. Because improved science education has been identified as an explicit national goal, the purpose of this mixed methods study was to determine whether traditional teaching tools (notes, lecture, and textbook) or 21st century teaching tools (online tutorials, video games, YouTube, and virtual labs) lead to greater gains in students' science learning. Bruner's constructivist and Bandura's social cognitive theories served as the foundations for the study. Quantitative research questions were used to investigate the relationship between the type of teaching tools used and student learning gains. Quantitative data from students' pre and posttests were collected and analyzed using a dependent samples t-test. Qualitative data were collected through a focus group interview and participant journals. Analysis of the qualitative data included coding the data and writing a descriptive narrative to convey the findings. Results showed no statistically significant differences in students' science achievement: both types of teaching tools led to student learning gains. As a result, an action plan was developed to assist science educators in the implementation of traditional and 21st century teaching tools that can be used to improve students' science learning. Implications for positive social change included providing science educators with a specific plan of action that will enhance students' science learning, thereby increasing science scores on the state and other high stakes tests.

  11. Judgments of Learning in Collaborative Learning Environments

    NARCIS (Netherlands)

    Helsdingen, Anne

    2010-01-01

    Helsdingen, A. S. (2010, March). Judgments of Learning in Collaborative Learning Environments. Poster presented at the 1st International Air Transport and Operations Symposium (ATOS 2010), Delft, The Netherlands: Delft University of Technology.

  12. Organ accumulation and subcellular location of Cicer arietinum ST1 protein.

    Science.gov (United States)

    Albornos, Lucía; Cabrera, Javier; Hernández-Nistal, Josefina; Martín, Ignacio; Labrador, Emilia; Dopico, Berta

    2014-07-01

    The ST (ShooT Specific) proteins are a new family of proteins characterized by a signal peptide, tandem repeats of 25/26 amino acids, and a domain of unknown function (DUF2775), whose presence is limited to a few families of dicotyledonous plants, mainly Fabaceae and Asteraceae. Their function remains unknown, although involvement in plant growth, fruit morphogenesis or in biotic and abiotic interactions have been suggested. This work is focused on ST1, a Cicer arietinum ST protein. We established the protein accumulation in different tissues and organs of chickpea seedlings and plants and its subcellular localization, which could indicate the possible function of ST1. The raising of specific antibodies against ST1 protein revealed that its accumulation in epicotyls and radicles was related to their elongation rate. Its pattern of tissue location in cotyledons during seed formation and early seed germination, as well as its localization in the perivascular fibres of epicotyls and radicles, indicated a possible involvement in seed germination and seedling growth. ST1 protein appears both inside the cell and in the cell wall. This double subcellular localization was found in every organ in which the ST1 protein was detected: seeds, cotyledons and seedling epicotyls and radicles. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  13. There's No Place Like Home: The Profitability Gap between Headquarters and their Foreign Subsidiaries

    OpenAIRE

    Dischinger, Matthias; Riedel, Nadine

    2009-01-01

    Using a large panel data set for European firms, this paper provides evidence that operations at multinational headquarters are significantly more profitable than perations at their foreign subsidiaries. The effect turns out to be robust and quantitatively large. Our findings suggest that the profitability gap is partly driven by agency costs which arise if value-driving functions are managed by a subsidiary that is geographically separated from the headquarters management. In line with falli...

  14. 1st International Conference on Machine Learning for Cyber Physical Systems and Industry 4.0

    CERN Document Server

    Beyerer, Jürgen

    2016-01-01

    The work presents new approaches to Machine Learning for Cyber Physical Systems, experiences and visions. It contains some selected papers from the international Conference ML4CPS – Machine Learning for Cyber Physical Systems, which was held in Lemgo, October 1-2, 2015. Cyber Physical Systems are characterized by their ability to adapt and to learn: They analyze their environment and, based on observations, they learn patterns, correlations and predictive models. Typical applications are condition monitoring, predictive maintenance, image processing and diagnosis. Machine Learning is the key technology for these developments.

  15. Attention in words, not in deeds : Effects of attention dissonance on headquarters-subsidiary communication in multinational corporations

    NARCIS (Netherlands)

    ul Haq, Hammad; Drogendijk, Rian; Blankenburg Holm, Desiree

    2017-01-01

    We introduce the notion of attention dissonance, where the subsidiary within a headquarter-subsidiary relationship feels that headquarters’ attention at the cognitive level, reflected in its strategic intentions (attention perspective), is not aligned with the routine actions the headquarters

  16. The Impact of Headquarter and Subsidiary Locations on Multinationals' Effective Tax Rates

    OpenAIRE

    Kevin S. Markle; Douglas A. Shackelford

    2013-01-01

    We examine effective tax rates (ETRs) for 9,022 multinationals from 87 countries from 2006 to 2011. We find that, despite extensive investments in international tax avoidance, multinationals headquartered in Japan, the United States, and some high-tax European countries continue to face substantially higher worldwide taxes than their counterparts in havens and other less heavily taxed locations. Other findings include: (1) effective tax rates remained steady over the investigation period; (2)...

  17. Promoting Children's Learning through Technology Literacy: Challenges to School Librarians in the 21st Century

    Science.gov (United States)

    Ejikeme, Anthonia N.; Okpala, Helen N.

    2017-01-01

    In today's world of technological revolution, children need to be encouraged to be ready to acquire lifelong knowledge and skills in the 21st century. This paper presents an overview of the application of technologies in children's learning environment which apparently will give them the opportunity of making use of their thinking skills in order…

  18. The Texts of The Agency's Agreements with the Republic of Austria. I. Headquarters Agreement. Amendments

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1970-09-04

    The text of the Agreement between the International Atomic Energy Agency and the Republic of Austria Amending the Agreement of 11 December 1957 Regarding the Headquarters of the International Atomic Energy Agency, which was signed on 4 June 1970, is reproduced in this document for the information of all Members. Members will be informed of the entry into force of the Amendments to the Headquarters Agreement.

  19. The Texts of The Agency's Agreements with the Republic of Austria. I. Headquarters Agreement. Amendments

    International Nuclear Information System (INIS)

    1970-01-01

    The text of the Agreement between the International Atomic Energy Agency and the Republic of Austria Amending the Agreement of 11 December 1957 Regarding the Headquarters of the International Atomic Energy Agency, which was signed on 4 June 1970, is reproduced in this document for the information of all Members. Members will be informed of the entry into force of the Amendments to the Headquarters Agreement

  20. Proceedings of the 1st international scientific conference "Teaching methods for economics and business sciences"

    OpenAIRE

    2017-01-01

    Teaching is a challenging but also a rewarding profession. It is underpinned by one key question: how do we build a good teaching and learning environment so that our students can acquire professional competences which will enable them to be successful in today’s global business environment. These proceedings include the papers presented at the 1st International Scientific Conference »Teaching Methods for Economics and Business Sciences« held on 8 May 2017 at the University of Maribor, F...

  1. Reinventing medical teaching and learning for the 21st century: Blended and flipped strategies

    Directory of Open Access Journals (Sweden)

    Carol A Miles

    2017-01-01

    Full Text Available There has been a recent rapid increase in the integration of flipped and blended modes of learning into Australian university classrooms. In the move to realize the benefits of these modes of delivery, universities are spending a great deal of time focusing on course redesign and upskilling teachers to assist in the adoption of these new methods of instruction. Large-scale blended learning projects have been completed at The University of Newcastle, Australia. One such project has been the integration of flipped and blended learning strategies into the redesign of the 1st year medical science course as part of a total undergraduate medical curriculum redesign. This course involves a large number of lecturers from a wide variety of disciplines. This involved not only the redesign of this course but also the introduction of new teaching materials and learning objects. To ensure success, this work required input from three groups: the academics teaching the course, the students taking the course, and the instructional designers who create the learning objects. The University of Newcastle, Australia, was instrumental in introducing problem-based learning (PBL to medical schools in Australian universities with its initial intake of medical students in 1978 and continues the use of this methodology as its primary teaching approach. As the current project develops, it has become apparent the pioneering work previously undertaken to implement PBL, in fact, had incorporated many of the pedagogical principles and strategies of what is now considered blended learning in the flipped classroom (albeit without the technology components. This paper argues that our teachers and students will more easily adapt to the requirements inherent in blended or flipped learning due to previous familiarity with PBL strategies.

  2. Using the learning management evaluation model for advancing to life skills of lower secondary students in the 21st century

    Science.gov (United States)

    Kansaart, Preecha; Suikraduang, Arun; Panya, Piyatida

    2018-01-01

    The aims of this research study were to develop the Learning Management Evaluation Model (LMEM) for advancing to lower secondary students of their life skills in the 21st century with the Research & Development process technique. The research procedures were administered of four steps that composed of analyze, the synthetic indicator to assess learning to advance to their life skills in the 21st century by the 4-educational experts were interviewed. The LMEM model was developed by the information from the first draft format and the educational experts to check a suitability and feasibility of the draft assessment form with a technical symposium multipath characteristics to find consensus dimensional (Multi-Attribute Consensus Reaching: MACR) by 12 specialists who provided the instruction in the form of Assessment and Evaluation Guide (AEG) was brought to five the number of professionals who ensure the proper coverage, a clear assessment of the manual before using the AEG. The LMEM model was to trial at an experiment with different schools in the Secondary Educational Office Area 26 (Maha Sarakham) whereas taught at the upper secondary educational school with the sample consisted of 7 schools with the purposive sampling was selected. Assessing the LMEM model was evaluated the based on the evaluation criteria of the educational development. The assessor was related to the trial consisted of 35 evaluators. Using the interview form with the rubric score and a five rating scale level was analyzed; the qualitative and quantitative data were used. It has found that: The LMEM evaluation model of learning to advance to life skills of students in the 21st century was a chart structure that ties together of 6 relevant components of the evaluation such as; the purpose of the assessment, the evaluation focused assessment methods, the evaluator, the evaluation technique, and the evaluation criteria. The evaluation targets were to assess the management of learning, the factors

  3. RESTAURANT AND CAFETERIA SERVICES ARRANGEMENTS FOR MAY 1ST, 2001

    CERN Multimedia

    Restaurant Supervisory Committee

    2001-01-01

    1. Restaurants As Tuesday, May 1st, is an official CERN holiday, restaurants no 2 (DSR : Bldg. 504 - Meyrin) and no 3 (Avenance : Bldg. 866 - Prévessin) will be closed as from Monday, April 30 at 18h00. They will reopen on Wednesday, May 2nd at 6h30 (rest. no 2) and at 7h00 (rest. no 3). On May 1st, a limited service will be provided by restaurant no. 1 (COOP : Bldg. 501 - Meyrin) from 8h00 to 21h00 with hot meals served from 11h30 to 14h00 and from 18h00 to 19h30. 2. Satellite cafétérias All satellite cafétérias will be closed on May 1st. They will all operate normally on Monday, April 30, except for buildings 17 (Meyrin), 865 and 892 (Prévessin) which will be closed. 3. Newspaper stand The newspaper kiosque in building 501 will be closed on May 1st.

  4. 1st quarterly report 1977

    International Nuclear Information System (INIS)

    1977-06-01

    The present report describes the activities carried out in the 1st quarter of 1977 at the Gesellschaft fuer Kernforschung in Karlsruhe or on its behalf in the framework of the fast breeder project (PSB). The problems and main results of the partial projects fuel rod development, materials testing, reactor physics, reactor safety and reactor technology are presented. (RW) [de

  5. A Deep Learning Approach to Examine Ischemic ST Changes in Ambulatory ECG Recordings.

    Science.gov (United States)

    Xiao, Ran; Xu, Yuan; Pelter, Michele M; Mortara, David W; Hu, Xiao

    2018-01-01

    Patients with suspected acute coronary syndrome (ACS) are at risk of transient myocardial ischemia (TMI), which could lead to serious morbidity or even mortality. Early detection of myocardial ischemia can reduce damage to heart tissues and improve patient condition. Significant ST change in the electrocardiogram (ECG) is an important marker for detecting myocardial ischemia during the rule-out phase of potential ACS. However, current ECG monitoring software is vastly underused due to excessive false alarms. The present study aims to tackle this problem by combining a novel image-based approach with deep learning techniques to improve the detection accuracy of significant ST depression change. The obtained convolutional neural network (CNN) model yields an average area under the curve (AUC) at 89.6% from an independent testing set. At selected optimal cutoff thresholds, the proposed model yields a mean sensitivity at 84.4% while maintaining specificity at 84.9%.

  6. From 21st century skills to 21st century human being

    DEFF Research Database (Denmark)

    Hjøllund, Niels-Peder Osmundsen; Jørgensen, Tobias Heiberg

    2017-01-01

    In Denmark, in Scandinavia and in all of Europe there is a lot of talk about the skills of the future. But if we want our students to aim for and gain a different learning outcome, we must set new and different standards for the way we teach – and start to walk the talk. The focus of the presenta...... CLD and we must take the next step, where we stop thinking about skills and competencies and start thinking and acting on the fundamental existential implication of the 21st century. What we need now is not more 21st century skills, but 21st century human beings....

  7. THE ENVIRONMENTAL STRATEGY OF MULTINATIONAL ENTERPRISE - MANAGING THE RELATIONSHIP BETWEEN THE HEADQUARTER AND SUBSIDIARIES

    Directory of Open Access Journals (Sweden)

    Roselei Haag

    2017-04-01

    Full Text Available This paper presents a literature review that searches to understand how the environmental strategy must be diffused throughout the structure of the multinational enterprise (MNE, within the scope of the studies on enterprises’ internationalization. Literature has contributed to the understanding of the relationships between headquarters and subsidiaries of MNEs, identifying contingencies where the headquarters should grant greater autonomy to certain subsidiaries. After analyzing the literature, we propose a research agenda seeking to expand the field of knowledge on the adoption of sustainability strategies in subsidiaries.

  8. The Role of ICT in the Teaching and Learning of History in the 21st Century

    Science.gov (United States)

    Adesote, S. A; Fatoki, O. R

    2013-01-01

    This paper examines the role of Information and Communication Technology in the Teaching and Learning of History in the Senior Secondary School in the 21st century. The new Information and communication technologies of internet and multimedia which have led to positive impact in the field of education in most developed countries are still at…

  9. Mastery learning: it is time for medical education to join the 21st century.

    Science.gov (United States)

    McGaghie, William C

    2015-11-01

    Clinical medical education in the 21st century is grounded in a 19th-century model that relies on longitudinal exposure to patients as the curriculum focus. The assumption is that medical students and postgraduate residents will learn from experience, that vicarious or direct involvement in patient care is the best teacher. The weight of evidence shows, however, that results from such traditional clinical education are uneven at best. Educational inertia endorsed until recently by medical school accreditation policies has maintained the clinical medical education status quo for decades.Mastery learning is a new paradigm for medical education. Basic principles of mastery learning are that educational excellence is expected and can be achieved by all learners and that little or no variation in measured outcomes will result. This Commentary describes the origins of mastery learning and presents its essential features. The Commentary then introduces the eight reports that comprise the mastery learning cluster for this issue of Academic Medicine. The reports are intended to help medical educators recognize advantages of the mastery model and begin to implement mastery learning at their own institutions. The Commentary concludes with brief statements about future directions for mastery learning program development and research in medical education.

  10. Cleavage of ST6Gal I by Radiation-Induced BACE1 Inhibits Golgi-Anchored ST6Gal I-Mediated Sialylation of Integrin β1 and Migration in Colon Cancer Cells

    International Nuclear Information System (INIS)

    Lee, Minyoung; Park, Jung-Jin; Ko, Young-Gyu; Lee, Yun-Sil

    2012-01-01

    Previously, we found that β-galactoside α2,6-sialyltransferase (ST6Gal I), an enzyme that adds sialic acids to N-linked oligosaccharides of glycoproteins and is frequently overexpressed in cancer cells, is up-regulated by ionizing radiation (IR) and cleaved to a form possessing catalytic activity comparable to that of the Golgi-localized enzyme. Moreover, this soluble form is secreted into the culture media. Induction of ST6Gal I significantly increased the migration of colon cancer cells via sialylation of integrin β1. Here, we further investigated the mechanisms underlying ST6Gal I cleavage, solubilization and release from cells, and addressed its functions, focusing primarily on cancer cell migration. We performed immunoblotting and lectin affinity assay to analyze the expression of ST6 Gal I and level of sialylated integrin β1. After ionizing radiation, migration of cells was measured by in vitro migration assay. α2, 6 sialylation level of cell surface was analyzed by flow cytometry. Cell culture media were concentrated and then analyzed for soluble ST6Gal I levels using an α2, 6 sialyltransferase sandwich ELISA. We found that ST6Gal I was cleaved by BACE1 (β-site amyloid precursor protein-cleaving enzyme), which was specifically overexpressed in response to IR. The soluble form of ST6Gal I, which also has sialyltransferase enzymatic activity, was cleaved from the Golgi membrane and then released into the culture media. Both non-cleaved and cleaved forms of ST6Gal I significantly increased colon cancer cell migration in a sialylation-dependent manner. The pro-migratory effect of the non-cleaved form of ST6Gal I was dependent on integrin β1 sialylation, whereas that of the cleaved form of ST6Gal I was not, suggesting that other intracellular sialylated molecules apart from cell surface molecules such as integrin β1 might be involved in mediating the pro-migratory effects of the soluble form of ST6Gal I. Moreover, production of soluble form ST6Gal I by

  11. The structural features of the sulfated heteropolysaccharide (ST-1) from Sargassum thunbergii and its neuroprotective activities.

    Science.gov (United States)

    Jin, Weihua; Liu, Bing; Li, Shuai; Chen, Jing; Tang, Hong; Jiang, Di; Zhang, Quanbin; Zhong, Weihong

    2018-03-01

    Polysaccharide (ST) was prepared from Sargassum thunbergii using hot water. Two fractions (ST-1 and ST-2) were prepared using anion exchange chromatography. One desulfated polysaccharide (ST-1-DS) was also prepared. Electrospray ionization mass spectrometry (ESI-MS) performed on ST-1-DS showed that the desulfated polysaccharides contained methyl glycosides of mono-sulfated and di-sulfated galacto-fucooligosaccharides. This result suggested that ST-1 might contain sulfated galactofucan, which consists of a backbone of alternating (Gal) n and (Fuc) n and sulfated randomly on Gal and mainly on C-2 in Fuc. In addition, ST-1 was degraded in 1M sulfuric acid. The solution was centrifuged, and the supernatant was concentrated and precipitated in ethanol to obtain the precipitate (ST-1-P). ST-1-P was then separated using gel chromatography and anion exchange chromatography to obtain the oligomers. ESI-MS spectra of oligomers indicated that ST-1 mostly contained sulfated glucuronomannan and fucoglucuronan. ESI-MS with collision-induced dissociation tandem mass spectrometry (ESI-CID-MS/MS) suggested that glucuronomannan contained alternating 2-linked Man and 4-linked GlcA, while fucoglucuronan contained 4-linked glucuronan with branched Fuc at C-3. Finally, the neuroprotective activities of ST, ST-1, ST-2 and MIX (a mixture of ST-1 and ST-2) were determined. ST showed the most neuroprotective activity, which indicated that ST might be a good candidate for curing neurodegenerative diseases. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. File list: His.Lar.05.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  13. File list: His.Lar.20.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  14. File list: His.Lar.50.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  15. File list: His.Lar.10.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  16. The Effect of Headquarter Integration Mechanisms on Subsidiaries’ New Product Success: From Control to Coordination Mechanism

    Directory of Open Access Journals (Sweden)

    Firmanzah

    2007-10-01

    Full Text Available New product launching (NPL to the local market by subsidiary managers is a strategic activity, which requires organizational supports from MNC global network. The NPL activity is marked by high level of uncertainty, risk, and market failure. Thus, a headquarter needs to integrate the subsidiary NPL into global strategy. There are two mechanisms to integrate subsidiaries’ activities during NPL process; coordination and control process. By testing the effect of each mechanism on role clarity and functional conflict, I found that coordination mechanism increase role clarity between headquarter and subsidiaries’ managers. In contrast, exercising control mechanism reduces role clarity and functional conflict between headquarter and subsidiaries’ managers during NPL. This research shows that both role clarity and functional conflict increase new product commercial performance introduced by subsidiary in the local market.

  17. Teacherpreneurs: a bold brand of teacher leadership for 21st-century teaching and learning.

    Science.gov (United States)

    Berry, Barnett

    2013-04-19

    Challenges facing our public schools demand a bold brand of teacher leadership. Teacherpreneurs, effective teachers who teach students regularly but also incubate and execute the kinds of policies and pedagogies students deserve, represent a new culture of training and ingenuity. Teachers who lead outside the classroom but do not lose their connection to students are best positioned to develop and disseminate best policies and practices for 21st-century teaching and learning.

  18. IDENTIFIKASI SURFAKTIN PADA PSEUDOMONAS FLUORESCENS ST1 PENGENDALI EFEKTIF PENYAKIT PUSTUL KEDELAI

    Directory of Open Access Journals (Sweden)

    Suskandini Ratih Dirmawati .

    2011-11-01

    Full Text Available Identification of surfactin in Pseudomonas fluorescens ST1 which effectively suppres soybean bacterial pustule.   Identification of surfactin in Pseudomonas fluorescens ST1 filtrate was conducted in Plant Pest and Disease Laboratory, Bogor Agriculture University.  The 48 hours cultured suspension of  P. fluorescens ST1 with 108 CFU/ml density was centrifuged to obtain the supernatant.  The supernatant was analyzed for its surfactin content by High Performance Liquid Chromatography with Colum ODS-5 and eluen acetonitril and acetat acid.  The result showed  that  surfactin was producted by P. fluorescens ST1 and this bioactive substance could suppres the bacterial pustule on soybean.

  19. The role of location in headquarters-subsidiaries relationships: An analysis of French multinationals in emerging markets

    OpenAIRE

    Hanane Beddi; Ulrike Mayrhofer

    2010-01-01

    International audience; This paper examines the role of location in the relationships established between headquarters and foreign subsidiaries. The analysis focuses on new challenges faced by MNEs from mature economies, considering the growing importance of subsidiaries located in emerging countries. The empirical study is based on three in-depth case-studies of French multinationals. The authors conducted 31 interviews with managers from both the headquarters and foreign subsidiaries. The f...

  20. Examining the 21st Century Classroom: Developing an Innovation Configuration Map

    Science.gov (United States)

    Donovan, Loretta; Green, Tim D.; Mason, Candice

    2014-01-01

    Despite it being the second decade of the 21st century, there still exists a range of definitions of what a 21st century learning environment is. This can be troublesome for teacher educators as we strive to prepare teachers for environments we can't clearly describe. In order to describe a 21st century learning environment, we developed an IC Map…

  1. Impact of human-associated Escherichia coli clonal groups in Antarctic pinnipeds: presence of ST73, ST95, ST141 and ST131.

    Science.gov (United States)

    Mora, Azucena; García-Peña, Francisco Javier; Alonso, María Pilar; Pedraza-Diaz, Susana; Ortega-Mora, Luis Miguel; Garcia-Parraga, Daniel; López, Cecilia; Viso, Susana; Dahbi, Ghizlane; Marzoa, Juan; Sergeant, Martin J; García, Vanesa; Blanco, Jorge

    2018-03-16

    There is growing concern about the spreading of human microorganisms in relatively untouched ecosystems such as the Antarctic region. For this reason, three pinniped species (Leptonychotes weddellii, Mirounga leonina and Arctocephalus gazella) from the west coast of the Antartic Peninsula were analysed for the presence of Escherichia spp. with the recovery of 158 E. coli and three E. albertii isolates. From those, 23 harboured different eae variants (α1, β1, β2, ε1, θ1, κ, ο), including a bfpA-positive isolate (O49:H10-A-ST206, eae-k) classified as typical enteropathogenic E. coli. Noteworthy, 62 of the 158 E. coli isolates (39.2%) exhibited the ExPEC status and 27 (17.1%) belonged to sequence types (ST) frequently occurring among urinary/bacteremia ExPEC clones: ST12, ST73, ST95, ST131 and ST141. We found similarities >85% within the PFGE-macrorrestriction profiles of pinniped and human clinic O2:H6-B2-ST141 and O16:H5/O25b:H4-B2-ST131 isolates. The in silico analysis of ST131 Cplx genomes from the three pinnipeds (five O25:H4-ST131/PST43-fimH22-virotype D; one O16:H5-ST131/PST506-fimH41; one O25:H4-ST6252/PST9-fimH22-virotype D1) identified IncF and IncI1 plasmids and revealed high core-genome similarities between pinniped and human isolates (H22 and H41 subclones). This is the first study to demonstrate the worrisome presence of human-associated E. coli clonal groups, including ST131, in Antarctic pinnipeds.

  2. ASIE Model: An Innovative Instructional Design Model for Teachers in Enhancing and Sustaining the Quality of the 21st Century Learning

    OpenAIRE

    Ismail Md Zain

    2017-01-01

    An effective and systematic design of instruction will determine the quality of learning and teaching practices. Hence, instructional design models are required, to move from just adopting a standard approach to developing models that have an impact on learners' profiles, creating a much better learning experience, skills, and knowledge both in the classroom and online. The 21st Century Learning Framework requires learners to develop their thinking skills, communication skills, collaborating ...

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  7. ASIE Model: An Innovative Instructional Design Model for Teachers in Enhancing and Sustaining the Quality of the 21st Century Learning

    Directory of Open Access Journals (Sweden)

    Ismail Md Zain

    2017-04-01

    Full Text Available An effective and systematic design of instruction will determine the quality of learning and teaching practices. Hence, instructional design models are required, to move from just adopting a standard approach to developing models that have an impact on learners' profiles, creating a much better learning experience, skills, and knowledge both in the classroom and online. The 21st Century Learning Framework requires learners to develop their thinking skills, communication skills, collaborating skills and enhancing their creativity, (4Cs towards establishing "globally competitive learners." An Integral ASIE Instructional Design Model is an innovative 21st Century teachers' designing tool that provides a solution to the above challenges. The Model assist teachers in Planning, Utilizing and Sharing (PLUS instructions with others across nations. It promotes the Professional Learning Community practices where educationist, stakeholders, parents, and corporates work collaboratively ensuring its quality and sustainability in addressing the future employability issues of the learners. Results from 5 Likert Scales Questionnaires given to teachers in workshops and pilot project conducted, shows positive views on the model.

  8. 21st centuries skill implication on educational system

    Science.gov (United States)

    Wrahatnolo, T.; Munoto

    2018-01-01

    The purpose of this article is to identify skill needed in 21st centuries and its implication on Indonesia’s educational system. This research found that the 21st centuries skill application has more measurable benefits in some sections of life, such as critical thinking and problem solving, initiative, creativity, and entrepreneurship, communication, teamwork, metacognition (change of mindset), digital literature. This study applied qualitative data analysis. The data were taken from different sources and literature. The analysis showed that The 21st centuries education concept’s implementation can be applied in the curriculum of the required subject that is addressed to achieve learning and innovation skills competence and also technology and information media skills competence. While supporting subject group directed to achieve life and career skills competence. All subjects are the derivation from core subject 3R, which are reading, writing, and arithmetic. Based on the description above, it can be concluded that 21st centuries skill needs; (1) a life planning; (2) flexibility and adaptability; (3) initiative and self-management (4) entrepreneurship; (5) social and cultural interaction; (6) productivity and accountability; (7) leadership; (8) critical thinking, (9) problem solving; (10) communication; (11) collaboration and teamwork; (12) lifelong learning; and (13) digital literation.

  9. 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-10-01

    The U.S. marine energy industry is actively pursuing development of offshore wind and marine hydrokinetic (MHK) energy systems. Experience in the wind energy sector demonstrates that new technology development requires thorough measurement and characterization of the environmental conditions prevalent at installation sites and of technology operating in the field. Presently, there are no turn-key instrumentation system solutions that meet the measurement needs of the marine energy industry. The 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop brought together technical experts from government laboratories, academia, and industry representatives from marine energy, wind, offshore oil and gas, and instrumentation developers to present and discuss the instrumentation needs of the marine energy industry. The goals of the meeting were to: 1. Share the latest relevant knowledge among technical experts; 2. Review relevant state-of-the-art field measurement technologies and methods; 3. Review lessons learned from recent field deployments; 4. Identify synergies across different industries; 5. Identify gaps between existing and needed instrumentation capabilities; 6. Understand who are the leading experts; 7. Provide a forum where stakeholders from the marine energy industry could provide substantive input in the development of new marine energy field deployable instrumentation packages.

  10. Reliability and Validity of Michigan School Libraries for the 21st Century Measurement Benchmarks

    Science.gov (United States)

    Floyd, Natosha N.

    2016-01-01

    The purpose of this study was to examine the psychometric properties of the Michigan School Libraries for the 21st Century Measurement Benchmarks (SL21). The instrument consists of 19 items with three subscales: Building the 21st Century Learning Environment Subscale, Teaching for 21st Century Learning Subscale, and Leading the Way to 21st Century…

  11. Rethinking Teacher Education: Synchronizing Eastern and Western Views of Teaching and Learning to Promote 21st Century Skills and Global Perspectives

    Science.gov (United States)

    Smith, Judith; Hu, Ran

    2013-01-01

    The purpose of the study was to share findings with educators across disciplines of how to incorporate an eastern and western blended philosophy of teaching and learning to promote 21st century skills and global perspectives. Drawing from a previous self-study of their views of teaching and learning between Chinese and American cultures, the two…

  12. Expression of Functional Human Sialyltransferases ST3Gal1 and ST6Gal1 in Escherichia coli.

    Directory of Open Access Journals (Sweden)

    Maria Elena Ortiz-Soto

    Full Text Available Sialyltransferases (STs are disulfide-containing, type II transmembrane glycoproteins that catalyze the transfer of sialic acid to proteins and lipids and participate in the synthesis of the core structure oligosaccharides of human milk. Sialic acids are found at the outermost position of glycostructures, playing a key role in health and disease. Sialylation is also essential for the production of recombinant therapeutic proteins (RTPs. Despite their importance, availability of sialyltransferases is limited due to the low levels of stable, soluble and active protein produced in bacterial expression systems, which hampers biochemical and structural studies on these enzymes and restricts biotechnological applications. We report the successful expression of active human sialyltransferases ST3Gal1 and ST6Gal1 in commercial Escherichia coli strains designed for production of disulfide-containing proteins. Fusion of hST3Gal1 with different solubility enhancers and substitution of exposed hydrophobic amino acids by negatively charged residues (supercharging-like approach were performed to promote solubility and folding. Co-expression of sialyltransferases with the chaperon/foldases sulfhydryl oxidase, protein disulfide isomerase and disulfide isomerase C was explored to improve the formation of native disulfide bonds. Active sialyltransferases fused with maltose binding protein (MBP were obtained in sufficient amounts for biochemical and structural studies when expressed under oxidative conditions and co-expression of folding factors increased the yields of active and properly folded sialyltransferases by 20%. Mutation of exposed hydrophobic amino acids increased recovery of active enzyme by 2.5-fold, yielding about 7 mg of purified protein per liter culture. Functionality of recombinant enzymes was evaluated in the synthesis of sialosides from the β-d-galactoside substrates lactose, N-acetyllactosamine and benzyl 2-acetamido-2-deoxy-3-O-(β-d-galactopyranosyl-α-d-galactopyranoside.

  13. Elementary School Teachers' Beliefs about the Role of Technology in 21st-Century Teaching and Learning

    Science.gov (United States)

    O'Neal, LaToya J.; Gibson, Philip; Cotten, Shelia R.

    2017-01-01

    Technological advancements have led to changes in the expectations placed on K-12 teachers. Teachers are now expected to better equip students with 21st-century skills, making it important to understand teachers' beliefs about the role of technology in teaching and learning and the skills their students need to be successful. Using a qualitative…

  14. The Effect of Headquarter Integration Mechanisms on Subsidiaries’ New Product Success: From Control to Coordination Mechanism

    Directory of Open Access Journals (Sweden)

    Firmanzah Firmanzah

    2013-07-01

    Full Text Available New product launching (NPL to the local market by subsidiary managers is a strategic activity, which requires organizational supports from MNC global network. The NPL activity is marked by high level of uncertainty, risk, and market failure. Thus, a headquarter needs to integrate the subsidiary NPL into global strategy. There are two mechanisms to integrate subsidiaries’ activities during NPL process; coordination and control process. By testing the effect of each mechanism on role clarity and functional conflict, I found that coordination mechanism increase role clarity between headquarter and subsidiaries’ managers. In contrast, exercising control mechanism reduces role clarity and functional conflict between headquarter and subsidiaries’ managers during NPL. This research shows that both role clarity and functional conflict increase new product commercial performance introduced by subsidiary in the local market. Keywords: new product launching (NPL, coordination mechanism, control mechanism, and new product performance

  15. 32 CFR 1605.8 - Staff of Region Headquarters for Selective Service.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Staff of Region Headquarters for Selective... SERVICE SYSTEM SELECTIVE SERVICE SYSTEM ORGANIZATION Region Administration § 1605.8 Staff of Region..., the staff of each region for Selective Service shall consist of as many officers, either military or...

  16. Examining the Efficacy of Project-Based Learning on Cultivating the 21st Century Skills among High School Students in a Global Context

    Science.gov (United States)

    Lin, Chi-Syan; Ma, Jung-Tsan; Kuo, Karen Yi-Chwen; Chou, Chien-Tzu Candace

    2015-01-01

    The goal of the study is to explore the opportunities and challenges associated with Project-Based Learning strategy in a global context on the aspects of both fostering learning community of practices and nurturing the 21st century skills. For collecting empirical data, the study implements and administers an online international project-based…

  17. Heart House: Where Doctors Learn

    Science.gov (United States)

    American School and University, 1978

    1978-01-01

    The new learning center and administrative headquarters of the American College of Cardiology in Bethesda, Maryland, contain a unique classroom equipped with the highly sophisticated audiovisual aids developed to teach the latest techniques in the diagnosis and treatment of heart disease. (Author/MLF)

  18. Imam Sahib Border Police Company Headquarters in Kunduz Province: $7.3 Million Facility Sits Largely Unused

    Science.gov (United States)

    2013-01-01

    Afghanistan Border Police Battalion (BN) Headquarters (HQ) to replace an existing sub-standard fac ility. The standard ABP BN HQ manning documents call for...current manning of the site revealed that an ABP BN HQ unit is now utilizing this as a headquarters. An ABP BN HQ has a tashkil manning of 59 personnel...The facility was built for 175 personnel. The difference in designs between an ABP battalion and a company is the amount of barrack space. The build

  19. Soybean Salt Tolerance 1 (GmST1) Reduces ROS Production, Enhances ABA Sensitivity, and Abiotic Stress Tolerance in Arabidopsis thaliana.

    Science.gov (United States)

    Ren, Shuxin; Lyle, Chimera; Jiang, Guo-Liang; Penumala, Abhishek

    2016-01-01

    Abiotic stresses, including high soil salinity, significantly reduce crop production worldwide. Salt tolerance in plants is a complex trait and is regulated by multiple mechanisms. Understanding the mechanisms and dissecting the components on their regulatory pathways will provide new insights, leading to novel strategies for the improvement of salt tolerance in agricultural and economic crops of importance. Here we report that soybean salt tolerance 1, named GmST1, exhibited strong tolerance to salt stress in the Arabidopsis transgenic lines. The GmST1-overexpressed Arabidopsis also increased sensitivity to ABA and decreased production of reactive oxygen species under salt stress. In addition, GmST1 significantly improved drought tolerance in Arabidopsis transgenic lines. GmST1 belongs to a 3-prime part of Glyma.03g171600 gene in the current version of soybean genome sequence annotation. However, comparative reverse transcription-polymerase chain reaction analysis around Glyma.03g171600 genomic region confirmed that GmST1 might serve as an intact gene in soybean leaf tissues. Unlike Glyma.03g171600 which was not expressed in leaves, GmST1 was strongly induced by salt treatment in the leaf tissues. By promoter analysis, a TATA box was detected to be positioned close to GmST1 start codon and a putative ABRE and a DRE cis-acting elements were identified at about 1 kb upstream of GmST1 gene. The data also indicated that GmST1-transgenic lines survived under drought stress and showed a significantly lower water loss than non-transgenic lines. In summary, our results suggest that overexpression of GmST1 significantly improves Arabidopsis tolerance to both salt and drought stresses and the gene may be a potential candidate for genetic engineering of salt- and drought-tolerant crops.

  20. Soybean salt tolerance 1 (GmST1 reduces ROS production, enhances ABA sensitivity and abiotic stress tolerance in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Shuxin eRen

    2016-04-01

    Full Text Available Abiotic stresses, including high soil salinity, significantly reduce crop production worldwide. Salt tolerance in plants is a complex trait and is regulated by multiple mechanisms. Understanding the mechanisms and dissecting the components on their regulatory pathways will provide new insights, leading to novel strategies for the improvement of salt tolerance in agricultural and economic crops of importance. Here we report that soybean salt tolerance 1, named GmST1, exhibited strong tolerance to salt stress in the Arabidopsis transgenic lines. The GmST1-overexpressed Arabidopsis also increased sensitivity to ABA and decreased production of reactive oxygen species (ROS under salt stress. In addition, GmST1 significantly improved drought tolerance in Arabidopsis transgenic lines. GmST1 belongs to a 3-prime part of Glyma.03g171600 gene in the current version of soybean genome sequence annotation. However, comparative RT-PCR analysis around Glyma.03g171600 genomic region confirmed that GmST1 might serve as an intact gene in soybean leaf tissues. Unlike Glyma.03g171600 which was not expressed in leaves, GmST1 was strongly induced by salt treatment in the leaf tissues. By promoter analysis, a TATA box was detected to be positioned close to GmST1 start codon and a putative ABRE and a DRE cis-acting elements were identified at about 1kb upstream of GmST1 gene. The data also indicated that GmST1-transgenic lines survived under drought stress and showed a significantly lower water loss than non-transgenic lines. In summary, our results suggest that overexpression of GmST1 significantly improves Arabidopsis tolerance to both salt and drought stresses and the gene may be a potential candidate for genetic engineering of salt- and drought-tolerant crops.

  1. RESTAURANT and CAFETERIA SERVICES: ARRANGEMENTS for MAY 1st, 2003

    CERN Document Server

    2003-01-01

    1. Restaurants As Thursday, May 1st, is an official CERN holiday, restaurants no. 2 (DSR : Bldg. 504 - Meyrin) and no. 3 (Avenance : Bldg. 866 - Prévessin) will be closed as from Wednesday, April 30 at 18h00. They will reopen on Friday, May 2nd at 6h30 (rest. no. 2) and at 7h00 (rest. no. 3). On May 1st, a limited service will be provided by restaurant no. 1 (COOP : Bldg. 501 - Meyrin) from 8h00 to 21h00 with hot meals served from 11h30 to 14h00 and from 18h00 to 19h30. 2. Newspaper stand The newspaper kiosque run by restaurant no. 1 in building 501 will be closed. 3. Decentralised services No decentralised services (satellite cafétérias etc.) will operate on May 1st, but will resume their normal activites on Friday, May 2nd, except for those dependent on restaurant no. 3 (Prévessin site) which will not reopen until Monday, May 5, 2003.

  2. The effect of negative performance stereotypes on learning.

    Science.gov (United States)

    Rydell, Robert J; Rydell, Michael T; Boucher, Kathryn L

    2010-12-01

    Stereotype threat (ST) research has focused exclusively on how negative group stereotypes reduce performance. The present work examines if pejorative stereotypes about women in math inhibit their ability to learn the mathematical rules and operations necessary to solve math problems. In Experiment 1, women experiencing ST had difficulty encoding math-related information into memory and, therefore, learned fewer mathematical rules and showed poorer math performance than did controls. In Experiment 2, women experiencing ST while learning modular arithmetic (MA) performed more poorly than did controls on easy MA problems; this effect was due to reduced learning of the mathematical operations underlying MA. In Experiment 3, ST reduced women's, but not men's, ability to learn abstract mathematical rules and to transfer these rules to a second, isomorphic task. This work provides the first evidence that negative stereotypes about women in math reduce their level of mathematical learning and demonstrates that reduced learning due to stereotype threat can lead to poorer performance in negatively stereotyped domains. PsycINFO Database Record (c) 2010 APA, all rights reserved.

  3. Characterization of StABF1, a stress-responsive bZIP transcription factor from Solanum tuberosum L. that is phosphorylated by StCDPK2 in vitro.

    Science.gov (United States)

    Muñiz García, María Noelia; Giammaria, Verónica; Grandellis, Carolina; Téllez-Iñón, María Teresa; Ulloa, Rita María; Capiati, Daniela Andrea

    2012-04-01

    ABF/AREB bZIP transcription factors mediate plant abiotic stress responses by regulating the expression of stress-related genes. These proteins bind to the abscisic acid (ABA)-responsive element (ABRE), which is the major cis-acting regulatory sequence in ABA-dependent gene expression. In an effort to understand the molecular mechanisms of abiotic stress resistance in cultivated potato (Solanum tuberosum L.), we have cloned and characterized an ABF/AREB-like transcription factor from potato, named StABF1. The predicted protein shares 45-57% identity with A. thaliana ABFs proteins and 96% identity with the S. lycopersicum SlAREB1 and presents all of the distinctive features of ABF/AREB transcription factors. Furthermore, StABF1 is able to bind to the ABRE in vitro. StABF1 gene is induced in response to ABA, drought, salt stress and cold, suggesting that it might be a key regulator of ABA-dependent stress signaling pathways in cultivated potato. StABF1 is phosphorylated in response to ABA and salt stress in a calcium-dependent manner, and we have identified a potato CDPK isoform (StCDPK2) that phosphorylates StABF1 in vitro. Interestingly, StABF1 expression is increased during tuber development and by tuber-inducing conditions (high sucrose/nitrogen ratio) in leaves. We also found that StABF1 calcium-dependent phosphorylation is stimulated by tuber-inducing conditions and inhibited by gibberellic acid, which inhibits tuberization.

  4. 21st Century Community Learning Centers: Stable Funding for Innovation and Continuous Improvement. Research Update: Highlights from the Out-of-School Time Database. Number 8

    Science.gov (United States)

    Wimer, Christopher; Harris, Erin

    2012-01-01

    As the only federal funding stream that provides dedicated funds for afterschool programs across the country, the 21st Century Community Learning Centers (21st CCLC) initiative plays an important role in supporting the innovation that takes place in afterschool programs. Social innovation has been defined as "a novel solution to a social…

  5. 21st CENTURY LEARNING: IS ICT REALLY INTEGRATED IN EFL CLASSROOM OR MERELY SEGREGATED OUTSIDE THE CLASSROOM?

    Directory of Open Access Journals (Sweden)

    Ririn Ovilia

    2017-06-01

    Full Text Available In 21st century, along with the rapid development of technology, the teachers begin to involve Information and Communication Technology (ICT in EFL learning. However, the case arises whether the use of ICT is really integrated or merely segregated outside the classroom. This study was a case study which attempted to see the practice of integrating ICT in EFL classroom, particularly in Charis School?a private Junior High School in Malang, and to investigate the students� and teacher�s perceptions toward the learning process. The instruments were interview guide, observation sheet, and questionnaire. The results of this study showed that the teacher was aware to integrate ICT in EFL classroom and the students showed positive attitudes in the learning process.

  6. An evaluation of solar energy for heating a highway maintenance headquarters building.

    Science.gov (United States)

    1985-01-01

    A highway maintenance area headquarters building having overall dimensions of 64 ft - 8 in by 42 ft - 0 in was equipped with an active solar heating system to assist in heating space and domestic hot water. The solar system was instrumented and its o...

  7. The Texts of the Agency's Headquarters Agreement with Austria and Related Agreements

    International Nuclear Information System (INIS)

    1975-01-01

    The texts of six agreements concluded between the Agency and the Republic of Austria as a result of the location of the Agency's headquarters in Austria, which were in force on 31 October 1975, are reproduced in this document for the information of all Members

  8. International Human Resources Management of Japanese, American, and European Firms in Asia : The Roles of Headquarters and Subsidiaries

    OpenAIRE

    Hiromichi Shibata; Andrew Doyle

    2006-01-01

    The main role of the headquarters international human resources departments/business units of seven Japanese firms we researched is to manage the Japanese expatriates at their subsidiaries in Asia; they have little involvement with the management of local employees. The headquarters international human resources departments/business units at five researched American firms tend to maintain strong company value/mission that drives use of their performance appraisal/promotion systems for employe...

  9. Fostering Creativity in the Classroom through Animated Storytelling - Challenges and Potentials for Arts-integration in 21st. Century Learning

    DEFF Research Database (Denmark)

    Gjedde, Lisa

    2016-01-01

    educators aware of the importance of integrating digital creativity in the teaching of the curriculum. However, in order to facilitate the integration of arts-based learning into the curriculum - not only as a subject but as a pathway to learning - new tools, competencies and mindsets are needed. This paper...... as a creative pathway to learning in primary education.......Creativity has been termed one of the most important skills of the 21st. Century classroom. While a traditional approach to education has not had a big emphasis on creativity in most subjects, the emerging learner-centered paradigm, as well as learners’ everday use of media, is making many...

  10. APPLICATION OF T. I. IN THE TEACHING-LEARNING PROCESS FOR THE ACQUISITION OF MATH KNOWLEDGE 1st GRADE OF SECONDARY EDUCATION "IMAT"

    Directory of Open Access Journals (Sweden)

    Ricardo Castro

    2017-12-01

    Full Text Available The present project focused on the creation of a T.I. with interactive multimedia content to support the mathematics subject 1st grade of secondary school. A fundamental element in its development lies in how the contents should be expressed and interpreted, that is, to respect the teaching-learning process pedagogically, taking advantage of visual and auditory products created from the potential of design and programming software tools. According to information concentrated and analyzed, we consider that one of the main problems that exists at the secondary level, specifically in the subject of mathematics, is that young people do not know or use supporting content for the study of this subject, for example: videos, audios, digital material complementary to books, etc., this means that the vast majority learns only what is seen in the classroom, as there are deficiencies, it generates impact on failure rates. It was based on two software development methodologies: ICONIX (1. ICONIX Process, sf 2016 that unifies object-oriented methods to cover the life cycle of a project and MeISE (2. Abud Figueroa, 2009 is a methodology focused on the development of educational software. Revisions were made to statistics of ENLACE test results from previous years and work was carried out on the revision of appropriate methodologies for the development of educational software, interviews with pedagogues were carried out and surveys were applied to students. We can say that the expression of the contents in the application of educational software is the essence of teaching, the structure and organization must adhere to the pedagogical process. Progress was made in determining a new methodology to develop educational software and significant advances in interactive multimedia content.

  11. A Holistic Approach to Knowledge Management and Social Learning: lessons learnt from military headquarters

    Directory of Open Access Journals (Sweden)

    Leoni Warne

    2001-11-01

    Full Text Available This paper reports on research conducted by the Enterprise Social Learning Architecture (ESLA team of the Defence Science and Technology Organisation. The ESLA team is investigating collaborative social learning within the Australian Defence Organisation (ADO. Social learning is tightly coupled to knowledge management. Three studies in three different settings have been conducted to date. The studies have provided multi-layered findings about social learning, and validated the use of ethnography for this purpose. Preliminary findings are discussed in this paper in terms of identified enablers and motivators for effective social learning and knowledge management. Although the paper deals with the defence environment, the findings can be generalised to other organisational settings, as the study deals with understanding the issues inherent in building sustainable and adaptive learning organisations.

  12. Assessing STEM content learning: using the Arctic's changing climate to develop 21st century learner

    Science.gov (United States)

    Henderson, G. R.; Durkin, S.; Moran, A.

    2016-12-01

    In recent years the U.S. federal government has called for an increased focus on science, technology, engineering, and mathematics (STEM) in the educational system to ensure that there will be sufficient technical expertise to meet the needs of business and industry. As a direct result of this STEM emphasis, the number of outreach activities aimed at actively engaging these students in STEM learning has surged. Such activities, frequently in the form of summer camps led by university faculty, have targeted primary and secondary school students with the goal of growing student interest in STEM majors and STEM careers. This study assesses short-term content learning using a climate module that highlights rapidly changing Arctic climate conditions to illustrate concepts of radiative energy balance and climate feedback. Hands-on measurement of short and longwave radiation using simple instrumentation is used to demonstrate concepts that are then related back to the "big picture" Arctic issue. Pre and post module questionnaires were used to assess content learning, as this learning type has been identified as the basis for STEM literacy and the vehicle by which 21st century learning skills are usually developed. In this instance, students applied subject knowledge they gained by taking radiation measurements to better understand the real-world problem of climate change.

  13. Creating a supportive learning environment for students with learning difficulties

    OpenAIRE

    Grah, Jana

    2013-01-01

    Co-building of supporting learning environment for the learners with learning difficulties is one of the 21st century inclusive school’s elements. Since the physical presence of learners with learning difficulties in the classroom does not self-evidently lead to an effective co-operation and implementation of 21st century inclusive school, I have dedicated my doctor thesis to the establishment of supporting learning environment for the learners with learning difficulties in primary school wit...

  14. When Salespeople Harbor Negative Stereotypes of their Corporate Headquarters : How Harmful is it and How can it be Avoided

    OpenAIRE

    Homburg, Christian; Wieseke, Jan; Lukas, Bryan A.; Mikolon, Sven

    2011-01-01

    This study examines the performance implications that organizations may suffer when their salespeople develop negative stereotypes of their corporate headquarters. How such stereotypes can be remedied through managerial action is also examined. The study draws on matched data from four different sources: sales managers, salespeople, customers, and company reports. Findings indicate that negative headquarters stereotypes among salespeople are associated with poor marketing-related performance ...

  15. Generation Z, Meet Cooperative Learning

    Science.gov (United States)

    Igel, Charles; Urquhart, Vicki

    2012-01-01

    Today's Generation Z teens need to develop teamwork and social learning skills to be successful in the 21st century workplace. Teachers can help students develop these skills and enhance academic achievement by implementing cooperative learning strategies. Three key principles for successful cooperative learning are discussed. (Contains 1 figure.)

  16. The development of learning competency and skills for the 21st century to integrate "TPCK" of world life with local environment in students grade 11

    Science.gov (United States)

    Jedaman, Pornchai; Kinboon, Nittayaporn; Suksup, Chareon; Kinboon, Wutcharapong

    2018-01-01

    The teaching strategies of append were the technological pedagogical content knowledge; TPCK. This description knowledge in a content to corresponds of a effective teaching. This article aims to address the relevance of; 1) the learning competency and skills for the 21st Century to integrate "TPCK" of a world life with local environment in the students grade 11, 2) the effective achievement of the learning competency and skills to integrate "TPCK" of world life with local environment in the students grade 11 were the passing score of a percentage 80 upwards (EI.), and 3) the attitudes for learning activities in the students grade 11. The study employed both quantitative and qualitative approaches for 9teachers of third schools were the participatory action research (PAR) in collecting data including a instructional, a testing, and a questionnaire surveywith 33 students grade 11 of Phuwiengwittayakom school. The participants werecluster random sampling. The data analysis of descriptive statistical, percentage, mean average, standard deviation. The findings in the study were to learning competency and skills for the 21st Century to integrate "TPCK" of a world life with local environment on TK, PK, CK, and TCK at a excellent levels (X¯ = 3.62, 3.57, 3.54, 3.51) respectively, and PCK, TPK,TPCK at a good levels (X¯ = 3.36, 3.23, 3.17) respectively. The effective achievement of the learning competency and skills to integrate "TPCK" of world life with local environment in 30 students grade 11 were the passing score (EI.) of a percentage at 90.91. The attitudes for learning activities in the students grade 11 at a high levels (X¯ =3.29). In addition of the students grade 11 to understanding of the importance were a local learning resources including the value integrating technology of the knowledge technology and to choose the right were create of an effective information.

  17. EMSL Quarterly Highlights Report: 1st Quarter, FY08

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Mary Ann

    2008-01-28

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2007 - December 2007) of Fiscal Year 2008.

  18. Exploring The Moon through a 21st Century Learning Environment of Interactive Whiteboards

    Science.gov (United States)

    Runyon, C. J.; Hall, C.; Joyner, E.; Meyer, H. M.

    2012-12-01

    Lunar exploration has an important role to play in inspiring students to hone their skills and understanding, as well as encouraging them to pursue careers in science, technology engineering and math (STEM). Many of NASA's current lunar educational materials do not dynamically engage the whole learner or effectively address 21st Century skills. We present examples of several dynamic lunar science activities for use on interactive white boards. These activities are replicable and incorporate NASA mission-derived sampling and analysis techniques. Building on a highly visual and tactile workforce, it is imperative that today's classrooms keep up with technologies that are the media of modern life. Interactive white boards offer a coordinated curricula and supporting resources that are immediately usable in most classrooms across America. Our dynamic classroom materials are rich in scientific processes, meet the national standards of learning in STEM, and are teacher-vetted for content and usability. Incorporating educational activities created from the NASA Lunar Science Institute team activities, the Moon Mineralogy Mapper (M3) Educator's Guide, and more current NASA lunar missions, we offer three dynamic modules for use on an interactive white board. SMART activities implement the mastery teaching model, employing instructional strategies so that all students can achieve the same level of learning. Our goal is to provide educators with multiple resources for teaching their students about the Moon and engaging their interest in pursuing STEM in the future. In addition to background information, inquiry-oriented lessons allow students to gather information and data directly through the Internet. For example, with the return of high resolution/high spatial data from M3/Chandrayaan-1, we can now better identify, discern and understand the compositional variations on the lunar surface. Data and analysis techniques from the M3 imaging spectrometer are incorporated into

  19. Recommender Systems in Technology Enhanced Learning

    NARCIS (Netherlands)

    Manouselis, Nikos; Drachsler, Hendrik; Verbert, Katrien; Santos, Olga

    2010-01-01

    Manouselis, N., Drachsler, H., Verbert, K., & Santos, C. S. (Eds.) (2010). Recommender System in Technology Enhanced Learning. Elsevier Procedia Computer Science: Volume 1, Issue 2. Proceedings of the 1st Workshop on Recommender Systems for Technology Enhanced Learning (RecSysTEL). September, 29-30,

  20. Status of Design and Manufacturing of ITER 1st batch Assembly Tools

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Jin Ho; Nam, Kyoun Go; Chung, Si Kun; Ha, Min Su [ITER Korea National Fusion Research Institute, Daejeon (Korea, Republic of); Kim, Geun Hong [ITER Organization, St Paul lez Durance (France)

    2016-05-15

    The ITER tokamak assembly tools are purpose-built and specially designed to complete the ITER tokamak machine which includes; Vacuum Vessel (VV), VV Thermal Shield (VVTS), Toroidal Field Coil (TFC) and other components contained in the cryostat. KODA has carried out the preliminary and final design of these assembly tools. This paper shows that the current status, first quarter of the 2016, including manufacturing of ITER 1st batch assembly tools and briefly summarized the design process through design work of Sector Sub-assembly Tool (SSAT) that is most important tool representing ITER 1st batch assembly tools. KODA (Korea Domestic Agency) should provide 128 kinds of the purpose-built assembly tools for ITER Tokamak machine, and the ITER 1st batch assembly tools are split into 3 groups. The FDR for Group A was performed in December 2014, and design of SSAT has been verified by FE analysis and engineering calculation using EN cords. The SSAT is now under manufacturing phase to meet the ITER milestone. After factory acceptance test of SSAT on end of 2016, the 1st SSAT will be delivered and arrived in ITER site on second quarter of the 2017.

  1. Enhancement of knowledge construction activities utilizing 21st century learning design rubric

    Science.gov (United States)

    Pedoche, Margarette Anne U.; Taladua, Janica Mae M.; Panal, Geicky Pearl C.; Magsayo, Joy R.; Guarin, Rica Mae B.; Myrna, H. Lahoylahoy

    2018-01-01

    The main objective of the study was to enhance knowledge construction activities on its design particularly the objectives, support materials, student activities and assessment tools. Activities from the 2nd Quarter of Science Learners Material were the basis in the adaptation of activities. The adapted activities were evaluated by the In-service Science teachers and undergone modification by the researchers based on the teacher's comments and suggestions. It was then evaluated, revised, and validated, tried-out using the 21st CLD Rubric. Subjects of the study were 110 students from Grade 7-B, Grade 7-D, Grade 7-F in Geronima Cabrera National High School, Kolambugan, Lanao del Norte during the academic year 2016-2017, the study to determine their learning capabilities investigated by the use of Knowledge Construction Activities in the 21st Century Classroom, to investigate how the lessons were understood and appreciated by students, to stimulate interpretation, analysis, synthesizing, or evaluating ideas and develop critical thinking. Both quantitative and qualitative data were obtained from the students' scores in three activities. Results showed that there was a significant difference between the pretest and posttest scores of students. Mean scores between the pretest and posttest showed a mean difference of 3.35, thus the null hypothesis was rejected. It could be concluded with sufficient evidence to show that the students had basically low prior knowledge about the topic ecosystem. A significant difference was seen in the pretest and posttest, scores of the activities and Ecosystem model results after the implementation phase that a knowledge construction type of activity was better than the traditional one for it promoted meaningful learning and active engagement of students. Based on the results, it was clear that the use of knowledge construction activities had an effect on student's achievement in comparison to traditional teaching method. Thus, it was

  2. 1st Roman Young Researchers Meeting Proceedings

    CERN Document Server

    Cannuccia, E; Pietrobon, D; Stellato, F; Veneziani, M

    2009-01-01

    During the last few decades scientists have been able to test the bases of the physics paradigms, where the quantum mechanics has to match the cosmological scales. Between the extremes of this scenario, biological phenomena and their complexity take place, challenging the laws we observe in the atomic and sub-atomic world. In order to explore the details of this world, new huge experimental facilities are under construction. These projects involve people coming from several countries and give physicists the opportunity to work together with chemists, biologists and other scientists. The Roman Young Researchers Meeting is a conference, organised by Ph. D. students and young postdocs connected to the Roman area. It is aimed primarily at graduate students and post-docs, working in physics. The 1st conference has been held on the 21st of July 2009 at the University of Roma Tor Vergata. It was organised in three sessions, devoted to Astrophysics and Cosmology, Soft and Condensed Matter Physics and Theoretical and ...

  3. Roegneria alashanica Keng: a species with the StStStYStY genome constitution.

    Science.gov (United States)

    Wang, Richard R-C; Jensen, Kevin B

    2017-06-01

    The genome constitution of tetraploid Roegneria alashanica Keng has been in question for a long time. Most scientific studies have suggested that R. alashanica had two versions of the St genome, St 1 St 2 , similar to that of Pseudoroegneria elytrigioides (C. Yen & J.L. Yang) B.R. Lu. A study, however, concluded that R. alashanica had the StY genome formula typical for tetraploid species of Roegneria. For the present study, R. alashanica, Elymus longearistatus (Bioss.) Tzvelev (StY genomes), Pseudoroegneria strigosa (M. Bieb.) Á. Löve (St), Pseudoroegneria libanoctica (Hackel) D.R. Dewey (St), and Pseudoroegneria spicata (Pursh) Á. Löve (St) were screened for the Y-genome specific marker B14(F+R) 269 . All E. longearistatus plants expressed intense bands specific to the Y genome. Only 6 of 10 R. alashanica plants exhibited relatively faint bands for the STS marker. Previously, the genome in species of Pseudoroegneria exhibiting such faint Y-genome specific marker was designated as St Y . Based on these results, R. alashanica lacks the Y genome in E. longearistatus but likely possess two remotely related St genomes, St and St Y . According to its genome constitution, R. alashanica should be classified in the genus Pseudoroenera and given the new name Pseudoroegneria alashanica (Keng) R.R.-C. Wang and K.B. Jensen.

  4. DEVELOPING THE 21ST-CENTURY SOCIAL STUDIES SKILLS THROUGH TECHNOLOGY INTEGRATION

    Directory of Open Access Journals (Sweden)

    Mohammad Imam FARISI

    2016-01-01

    Full Text Available Recently, technology has become an educational necessity in global-digital era. Facing these phenomena, social studies (SS should make innovations related to changes of 21st-century skills and learning paradigm, which is characterized by the principles of disclosure of information, computing, automation, and communication. Technology integration into SS learning is one of the learning innovations in the global-digital era, and powerfully supports the National Council for Social Studies (NCSS as stated in their visions: meaningful, powerful, value-based, challenging, and active. It also strongly supports the development of three core skills of the 21st-century, including learning and innovation skills; information, media and technology skills; life and career skills that developed in partnership with the Partnership Forum for 21st-Century Skills (P21. This paper examines and describes academics evolution toward a commitment and further developments in research; 21stcentury skills map for the SS; and the implications for developing teachers’ competences and teachers’ education curriculum.

  5. Electronic Health Records Place 1st at Indy 500

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues EHR Electronic Health Records Place 1st at Indy 500 Past ... last May's Indy 500 had thousands of personal Electronic Health Records on hand for those attending—and ...

  6. News from IAEA Headquarters

    International Nuclear Information System (INIS)

    1966-01-01

    Full text: Two more countries have joined the Agency - Panama and Jordan - bringing IAEA membership up to 96. Mr. Ginige Richard Walter de Silva (Ceylon) has been appointed Director of the Division of Conference and General Services of the Agency. Born in 1911 at Nugegeda, Ceylon, Mr. de Silva obtained his B.Sc. in Physics at London University and his M.A. in Physics and Mathematics at Cambridge University. He has had a long career in the Civil Service, mainly in the administrative, commercial and finance branches of government. Mr.de Silva took over from Mr. Arthur E. Barrett, Chief of the Conference and Engineering Services, who had been Acting Director of the Division for a long period of time, and who will be leaving the Agency later this year to take up work elsewhere. From the early days of IAEA in 1957, Mr. Barrett has been closely associated with the establishment of the Agency's temporary headquarters in Vienna. He has been in charge of the planning and design of the technical facilities for the various conference installations and responsible for the servicing of all the General Conference sessions since 1958. In fact, Mr. Barrett has played an essential part in the creation of the Vienna Congress Centre in the former Hofburg Imperial Palace. Educated at Cambridge and London Universities, Mr. Barrett has had some 35 years of public service, first in the BBC in London and subsequently with the United Nations in New York. (author)

  7. News from IAEA Headquarters

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1966-06-15

    Full text: Two more countries have joined the Agency - Panama and Jordan - bringing IAEA membership up to 96. Mr. Ginige Richard Walter de Silva (Ceylon) has been appointed Director of the Division of Conference and General Services of the Agency. Born in 1911 at Nugegeda, Ceylon, Mr. de Silva obtained his B.Sc. in Physics at London University and his M.A. in Physics and Mathematics at Cambridge University. He has had a long career in the Civil Service, mainly in the administrative, commercial and finance branches of government. Mr.de Silva took over from Mr. Arthur E. Barrett, Chief of the Conference and Engineering Services, who had been Acting Director of the Division for a long period of time, and who will be leaving the Agency later this year to take up work elsewhere. From the early days of IAEA in 1957, Mr. Barrett has been closely associated with the establishment of the Agency's temporary headquarters in Vienna. He has been in charge of the planning and design of the technical facilities for the various conference installations and responsible for the servicing of all the General Conference sessions since 1958. In fact, Mr. Barrett has played an essential part in the creation of the Vienna Congress Centre in the former Hofburg Imperial Palace. Educated at Cambridge and London Universities, Mr. Barrett has had some 35 years of public service, first in the BBC in London and subsequently with the United Nations in New York. (author)

  8. Twenty-First Century Learning: Communities, Interaction and Ubiquitous Computing

    Science.gov (United States)

    Leh, Amy S.C.; Kouba, Barbara; Davis, Dirk

    2005-01-01

    Advanced technology makes 21st century learning, communities and interactions unique and leads people to an era of ubiquitous computing. The purpose of this article is to contribute to the discussion of learning in the 21st century. The paper will review literature on learning community, community learning, interaction, 21st century learning and…

  9. Dimerization and endocytosis of the sucrose transporter StSUT1 in mature sieve elements.

    Science.gov (United States)

    Liesche, Johannes; Schulz, Alexander; Krügel, Undine; Grimm, Bernhard; Kühn, Christina

    2008-12-01

    The sucrose transporter StSUT1 from Solanum tuberosum was shown to be regulated post-translationally by redox reagents. Its activity is increased at least 10-fold in the presence of oxidizing agents if expressed in yeast. Oxidation has also an effect on plasma membrane targeting and dimerization of the protein. In response to oxidizing agents, StSUT1 is targeted to lipid raft-like microdomains and SUT1 protein is detectable in the detergent resistant membrane fraction of plant plasma membranes. Interestingly, StSUT1 treated with brefeldin A seems to aggregate in endocytic compartments in mature sieve elements.1 Further analysis of SUT1 targeting will certainly provide more information about the putative involvement of lipid raft-like microdomains in endocytic events. We provide here additional information on the dimerization and endocytosis of the SUT1 protein. The oligomerization of overexpressed SoSUT1 from Spinacia oleracea in transgenic potato plants was analyzed by two-dimensional gel electrophoresis and endocytosis of the StSUT1 protein was confirmed by immunogold labeling.

  10. A Scale Development for 21st Century Skills of Primary School Students: A Validity and Reliability Study1

    Directory of Open Access Journals (Sweden)

    Ş. Dilek Belet Boyacı

    2016-01-01

    Full Text Available The objective of the present study is to develop a measurement tool to assess 21st Century learning and innovation skills of primary school students. Study data was collected from 632 fourth grade students in five different primary schools during 2014 – 2015 academic year and data obtained from 609 fourth grade students were utilized in the study. The scale was developed in six stages. These were; establishing the scale items, consultation of experts, pretest stage, determination of structural validity, reliability assessment, and finalization of the scale, respectively. Cronbach alpha reliability coefficient for the whole scale, which consisted of three factors, was calculated as 0.95. 0.89. As a result of the current study, a Likert-type 21st Century learning and innovation skills scale with 39 items was developed. 20 items of the scale were related to creativity and innovation skills, 12 were related to critical thinking and problem solving skills, and 7 were related to cooperation and communication skills.

  11. Developing a Capacity Assessment Framework for Marine Logistics Groups

    Science.gov (United States)

    2017-02-20

    Corps, 2015; and 1st Marine Logistics Group, 2015. RAND RR1572-2.3 1st FSSG Headquarters Regiment Security Company CLR-1 CLR-15 7th ESB 1st Medical... Companies . Supply and maintenance battalions form the bulk of CLR-15. The Combat Logistics Companies are small, task-organized companies that support Marine...under- standing logistics capacity as it pertains to informing decisions to improve efficiencies and reduce costs . Most often these assessments of

  12. Building 21st. Century literacies through digital animated storytelling

    DEFF Research Database (Denmark)

    Gjedde, Lisa

    2016-01-01

    , auditory and verbal with a fluency with digital tools. There is an interest to teach multimodal literacy in open schooling, while bridging informal and formal learning in hybrid environments, that is involving collaboration with libraries and museums. Designs for multimodal learning with animation may have......This paper will present the preliminary findings from a R&D project on developing 21st. Century literacies in a digital Storylab at a public library, doing digital animated storytelling, in collaboration with municipal schools. It will explore the implications for the approach to digital story......-based learning for learner’s engagement, motivation and multimodal learning in a mixed methods study based on surveys, interviews and observations. The key literacy skills needed for 21st. Century learners have shifted from a predominant focus on verbal text towards multimodal literacies, that combine the visual...

  13. The role of SCUBE1 in the development of late stent thrombosis presenting with ST-elevation myocardial infarction.

    Science.gov (United States)

    Bolayır, Hasan Ata; Kıvrak, Tarık; Güneş, Hakan; Akaslan, Dursun; Şahin, Ömer; Bolayır, Aslı

    2018-05-01

    There is an important link between platelets and inflammation, thrombosis, and vascular and tissue repair mechanisms. SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1) may function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Stent thrombosis (ST) following percutaneous coronary intervention is an uncommon and potentially catastrophic event that can manifest as myocardial infarction and sudden death. High platelet reactivity is a risk factor for thrombotic events, including late ST. For this reason, in the current study, we researched the role of SCUBE1 in the development of late coronary ST. We included 40 patients admitted to our hospital with a diagnosis of ST-elevation myocardial infarction (STEMI) and signs of late ST on a coronary angiogram. For the control group, we recruited 50 healthy gender- and age-matched individuals who were seen for health check-ups. We also randomly included 100 patients with a diagnosis of STEMI without ST. There were no significant differences between the groups in terms of baseline and demographic characteristics. The mean SCUBE1 level in patients with STEMI with late ST at admission and the STEMI without ST group was significantly higher than in the control group (pST group was significantly higher than in the STEMI without ST group (p=0.03). In multivariate regression analysis, serum SCUBE1 (odds ratio [OR]: 1.022; 95% confidence interval [CI]: 1.011-1.033, pST. In addition, receiver operating characteristic curve analysis was used to determine the optimal SCUBE1 cut-off value for predicting late ST. The area under the curve was 0.972 (95% CI 0.95-0.98). The SCUBE1 cut-off value was 59.2 ng/ml, with a sensitivity of 95.4% and specificity of 82.9%. The present work is the first clinical study to demonstrate that serum SCUBE1 levels are significantly higher in patients with late ST and serum SCUBE1 was an independent predictor for the presence of late ST in our

  14. Implicit sequence learning in people with Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Katherine R Gamble

    2014-08-01

    Full Text Available Implicit sequence learning involves learning about dependencies in sequences of events without intent to learn or awareness of what has been learned. Sequence learning is related to striatal dopamine levels, striatal activation, and integrity of white matter connections. People with Parkinson’s disease (PD have degeneration of dopamine-producing neurons, leading to dopamine deficiency and therefore striatal deficits, and they have difficulties with sequencing, including complex language comprehension and postural stability. Most research on implicit sequence learning in PD has used motor-based tasks. However, because PD presents with motor deficits, it is difficult to assess whether learning itself is impaired in these tasks. The present study used an implicit sequence learning task with a reduced motor component, the Triplets Learning Task (TLT. People with PD and age- and education-matched healthy older adults completed three sessions (each consisting of 10 blocks of 50 trials of the TLT. Results revealed that the PD group was able to learn the sequence, however, when learning was examined using a Half Blocks analysis (Nemeth et al., 2013, which compared learning in the 1st 25/50 trials of all blocks to that in the 2nd 25/50 trials, the PD group showed significantly less learning than Controls in the 2nd Half Blocks, but not in the 1st. Nemeth et al. hypothesized that the 1st Half Blocks involve recall and reactivation of the sequence learned, thus reflecting hippocampal-dependent learning, while the 2nd Half Blocks involve proceduralized behavior of learned sequences, reflecting striatal-based learning. The present results suggest that the PD group had intact hippocampal-dependent implicit sequence learning, but impaired striatal-dependent learning. Thus, sequencing deficits in PD are likely due to striatal impairments, but other brain systems, such as the hippocampus, may be able to partially compensate for striatal decline to improve

  15. Proceedings of the 1st Symposium on Laser Spectroscopy

    International Nuclear Information System (INIS)

    1993-11-01

    This proceedings contains articles of the 1st Symposium on Laser Spectroscopy. It was held on Nov 11, 1993 in Taejeon, Korea. The main topics are as follows: Laser Isotope, Laser Spectroscopy, Laser Fusion, Laser Applications and so on. (Yi, J. H.)

  16. EMSL Quarterly Highlights Report: 1st Quarter, Fiscal Year 2009

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.

    2009-02-02

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2008 - December 2008) of Fiscal Year 2009.

  17. Smart Social Networking: 21st Century Teaching and Learning Skills

    Science.gov (United States)

    Boholano, Helen B.

    2017-01-01

    Education in the 21st century highlights globalization and internationalization. Pre-service teachers in the 21st century are technology savvy. To effectively engage and teach generation Z students, preservice teachers will help the educational system meet this requirement. The educational systems must be outfitted with a prerequisite of ICT…

  18. Comparative genomic analysis shows that avian pathogenic Escherichia coli isolate IMT5155 (O2:K1:H5; ST complex 95, ST140 shares close relationship with ST95 APEC O1:K1 and human ExPEC O18:K1 strains.

    Directory of Open Access Journals (Sweden)

    Xiangkai Zhu Ge

    Full Text Available Avian pathogenic E. coli and human extraintestinal pathogenic E. coli serotypes O1, O2 and O18 strains isolated from different hosts are generally located in phylogroup B2 and ST complex 95, and they share similar genetic characteristics and pathogenicity, with no or minimal host specificity. They are popular objects for the study of ExPEC genetic characteristics and pathogenesis in recent years. Here, we investigated the evolution and genetic blueprint of APEC pathotype by performing phylogenetic and comparative genome analysis of avian pathogenic E. coli strain IMT5155 (O2:K1:H5; ST complex 95, ST140 with other E. coli pathotypes. Phylogeny analyses indicated that IMT5155 has closest evolutionary relationship with APEC O1, IHE3034, and UTI89. Comparative genomic analysis showed that IMT5155 and APEC O1 shared significant genetic overlap/similarities with human ExPEC dominant O18:K1 strains (IHE3034 and UTI89. Furthermore, the unique PAI I5155 (GI-12 was identified and found to be conserved in APEC O2 serotype isolates. GI-7 and GI-16 encoding two typical T6SSs in IMT5155 might be useful markers for the identification of ExPEC dominant serotypes (O1, O2, and O18 strains. IMT5155 contained a ColV plasmid p1ColV5155, which defined the APEC pathotype. The distribution analysis of 10 sequenced ExPEC pan-genome virulence factors among 47 sequenced E. coli strains provided meaningful information for B2 APEC/ExPEC-specific virulence factors, including several adhesins, invasins, toxins, iron acquisition systems, and so on. The pathogenicity tests of IMT5155 and other APEC O1:K1 and O2:K1 serotypes strains (isolated in China through four animal models showed that they were highly virulent for avian colisepticemia and able to cause septicemia and meningitis in neonatal rats, suggesting zoonotic potential of these APEC O1:K1 and O2:K1 isolates.

  19. Corporate Language and Implications for Organizational Learning

    DEFF Research Database (Denmark)

    Zølner, Mette

    2013-01-01

    is insufficient to leverage contextually specific and culturally embedded knowledge. This indicates the need for disentangling language and culture. The paper further argues for the need to go beyond national language to consider how prevailing kinds of corporate talk may curb headquarters potential for learning...... from cultural and contextual diversity....

  20. The 21st century skills with model eliciting activities on linear program

    Science.gov (United States)

    Handajani, Septriana; Pratiwi, Hasih; Mardiyana

    2018-04-01

    Human resources in the 21st century are required to master various forms of skills, including critical thinking skills and problem solving. The teaching of the 21st century is a teaching that integrates literacy skills, knowledge, skills, attitudes, and mastery of ICT. This study aims to determine whether there are differences in the effect of applying Model Elliciting Activities (MEAs) that integrates 21st century skills, namely 4C and conventional learning to learning outcomes. This research was conducted at Vocational High School in the odd semester of 2017 and uses the experimental method. The experimental class is treated MEAs that integrates 4C skills and the control class is given conventional learning. Methods of data collection in this study using the method of documentation and test methods. The data analysis uses Z-test. Data obtained from experiment class and control class. The result of this study showed there are differences in the effect of applying MEAs that integrates 4C skills and conventional learning to learning outcomes. Classes with MEAs that integrates 4C skills give better learning outcomes than the ones in conventional learning classes. This happens because MEAs that integrates 4C skills can improved creativity skills, communication skills, collaboration skills, and problem-solving skills.

  1. 10 CFR 719.42 - What types of field actions must be coordinated with Headquarters?

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false What types of field actions must be coordinated with Headquarters? 719.42 Section 719.42 Energy DEPARTMENT OF ENERGY CONTRACTOR LEGAL MANAGEMENT REQUIREMENTS... adverse decisions, where legal issues of first impression, sensitive issues, issues of significance to the...

  2. The new Facilities Management contract at CERN from 1st July 2002

    CERN Document Server

    Mauro Nonis

    2002-01-01

    Within the ST Division, all the Facilities Management activities have been under the ST/TFM group responsibility until the 30th June 2002, who has performed them using around 20 industrial support contracts. Starting from the 1st July 2002 a new unit, ST/FM, will take over these activities that will be unified into one single contract that has been adjudicated to the company Facilities Management Network SA. This contract will be in charge of the maintenance and minor works on tertiary installations (i.e. all structures and installations that have no direct relation to the running of the accelerators) for the following trades: - Technical: heating, ventilation, air conditioning, plumbing, electricity, civil engineering (painting, roofing, glazing, blinds, fencing, masonry etc.), passenger and goods lifts, automatic and powered doors, kitchen equipment, roads, signs, keys and locks, office furniture, - Services: waste collection, security, green areas, cleaning and sanitary supplies, disinfection, rodent cont...

  3. THE NEW FACILITIES MANAGEMENT CONTRACT AT CERN FROM 1st JULY 2002

    CERN Multimedia

    Mauro Nonis

    2002-01-01

    Within the ST Division, all the Facilities Management activities have been under the ST/TFM group responsibility until the 30th June 2002, who has performed them using around 20 industrial support contracts. Starting from the 1st July 2002 a new unit, ST/FM, will take over these activities that will be unified into one single contract that has been adjudicated to the company Facilities Management Network SA. This contract will be in charge of the maintenance and minor works on tertiary installations (i.e. all structures and installations that have no direct relation to the running of the accelerators) for the following trades: Technical: heating, ventilation, air conditioning, plumbing, electricity, civil engineering (painting, roofing, glazing, blinds, fencing, masonry etc.), passenger and goods lifts, automatic and powered doors, kitchen equipment, roads, signs, keys and locks, office furniture, Services: waste collection, security, green areas, cleaning and sanitary supplies, disinfection, rodent contro...

  4. Comparison of Nasal Epithelial Smoking-Induced Gene Expression on Affymetrix Exon 1.0 and Gene 1.0 ST Arrays

    Directory of Open Access Journals (Sweden)

    Xiaoling Zhang

    2013-01-01

    Full Text Available We have previously defined the impact of tobacco smoking on nasal epithelium gene expression using Affymetrix Exon 1.0 ST arrays. In this paper, we compared the performance of the Affymetrix GeneChip Human Gene 1.0 ST array with the Human Exon 1.0 ST array for detecting nasal smoking-related gene expression changes. RNA collected from the nasal epithelium of five current smokers and five never smokers was hybridized to both arrays. While the intersample correlation within each array platform was relatively higher in the Gene array than that in the Exon array, the majority of the genes most changed by smoking were tightly correlated between platforms. Although neither array dataset was powered to detect differentially expressed genes (DEGs at a false discovery rate (FDR <0.05, we identified more DEGs than expected by chance using the Gene ST array. These findings suggest that while both platforms show a high degree of correlation for detecting smoking-induced differential gene expression changes, the Gene ST array may be a more cost-effective platform in a clinical setting for gene-level genomewide expression profiling and an effective tool for exploring the host response to cigarette smoking and other inhaled toxins.

  5. Controls Over Materiel Procured for Direct Vendor Delivery

    Science.gov (United States)

    1995-02-10

    National Guard, Company D, 560th Engineer Battalion, Bainbridge, GA Army National Guard, Company E, 121st Infantry Battalion, Tifton , GA Joint...Command, Fort Monmouth, NJ United States Army Forces Command, Atlanta, GA United States Army Materiel Command, Alexandria, VA United States Army...Fort Gillem, GA Headquarters, Fort Lee, Petersburg, VA Headquarters, Fort Riley, KS Headquarters, National Guard Bureau, Washington, DC Headquarters

  6. Unseen and Unheard? Women Managers and Organizational Learning

    Science.gov (United States)

    Martin, Lynn M.; Lord, Gemma; Warren-Smith, Izzy

    2018-01-01

    Purpose: This paper aims to use (in)visibility as a lens to understand the lived experience of six women managers in the headquarters of a large multinational organization in the UK to identify how "gender" is expressed in the context of organizational learning. Design/methodology/approach: The researchers take a phenomenological…

  7. ST peak during percutaneous coronary intervention serves as an early prognostic predictor in patients with ST-segment elevation myocardial

    DEFF Research Database (Denmark)

    Lønborg, Jacob; Kelbæk, Henning; Engstrøm, Thomas

    2014-01-01

    AIMS: To evaluate the clinical importance of the ST peak phenomenon during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS: Continuous ST monitoring was performed in 942 STEMI patients from arrival until 90...... minutes after revascularisation. ST peak was defined as ≥1 mm increase in the ST-segment during PCI compared with the ST elevation before intervention. ST peak was observed in 26.9% of patients. During median follow-up of 4.1 years, 20.7% of patients experienced a major adverse cardiac event (MACE). ST...... and ST peak including ST resolution and epicardial flow, ST peak remained significantly associated with MACE: adjusted hazard ratio (HR) 1.40 (95% confidence interval [CI] 1.01-1.95) and 1.41 (95% CI: 1.02-1.96). CONCLUSIONS: In the largest study hitherto evaluating the ST peak phenomenon during primary...

  8. Regulation of StAR by the N-terminal Domain and Coinduction of SIK1 and TIS11b/Znf36l1 in Single Cells.

    Science.gov (United States)

    Lee, Jinwoo; Tong, Tiegang; Duan, Haichuan; Foong, Yee Hoon; Musaitif, Ibrahim; Yamazaki, Takeshi; Jefcoate, Colin

    2016-01-01

    The cholesterol transfer function of steroidogenic acute regulatory protein (StAR) is uniquely integrated into adrenal cells, with mRNA translation and protein kinase A (PKA) phosphorylation occurring at the mitochondrial outer membrane (OMM). The StAR C-terminal cholesterol-binding domain (CBD) initiates mitochondrial intermembrane contacts to rapidly direct cholesterol to Cyp11a1 in the inner membrane (IMM). The conserved StAR N-terminal regulatory domain (NTD) includes a leader sequence targeting the CBD to OMM complexes that initiate cholesterol transfer. Here, we show how the NTD functions to enhance CBD activity delivers more efficiently from StAR mRNA in adrenal cells, and then how two factors hormonally restrain this process. NTD processing at two conserved sequence sites is selectively affected by StAR PKA phosphorylation. The CBD functions as a receptor to stimulate the OMM/IMM contacts that mediate transfer. The NTD controls the transit time that integrates extramitochondrial StAR effects on cholesterol homeostasis with other mitochondrial functions, including ATP generation, inter-organelle fusion, and the major permeability transition pore in partnership with other OMM proteins. PKA also rapidly induces two additional StAR modulators: salt-inducible kinase 1 (SIK1) and Znf36l1/Tis11b. Induced SIK1 attenuates the activity of CRTC2, a key mediator of StAR transcription and splicing, but only as cAMP levels decline. TIS11b inhibits translation and directs the endonuclease-mediated removal of the 3.5-kb StAR mRNA. Removal of either of these functions individually enhances cAMP-mediated induction of StAR. High-resolution fluorescence in situ hybridization (HR-FISH) of StAR RNA reveals asymmetric transcription at the gene locus and slow RNA splicing that delays mRNA formation, potentially to synchronize with cholesterol import. Adrenal cells may retain slow transcription to integrate with intermembrane NTD activation. HR-FISH resolves individual 3.5-kb St

  9. Idaho National Laboratory Quarterly Performance Analysis - 1st Quarter FY2015

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Lisbeth A. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 73 reportable events (27 from the 1St Qtr FY-15 and 46 from the prior three reporting quarters), as well as 38 other issue reports (including nine not reportable events and Significant Category A and B conditions reported during the1st Qtr FY-15) identified at INL during the past 12 months.

  10. TGF-β1 downregulates StAR expression and decreases progesterone production through Smad3 and ERK1/2 signaling pathways in human granulosa cells.

    Science.gov (United States)

    Fang, Lanlan; Chang, Hsun-Ming; Cheng, Jung-Chien; Leung, Peter C K; Sun, Ying-Pu

    2014-11-01

    Regulation of progesterone production in granulosa cells is important for normal reproductive functions. Steroidogenic acute regulatory protein (StAR) is recognized as the key regulatory protein involved in the rate-limiting step of steroidogenesis. TGF-β1 protein is detected in human follicular fluid, and TGF-β1 and its receptors are expressed in human granulosa cells. However, the functional role of TGF-β1 in the regulation of StAR expression and progesterone production in human granulosa cells remains unknown. Our objective was to investigate the effects of TGF-β1 on StAR expression and progesterone production in human granulosa cells. SVOG cells are human granulosa cells that were obtained from women undergoing in vitro fertilization and immortalized with SV40 large T antigen. SVOG cells were used to investigate the effects of TGF-β1 on StAR expression and progesterone production at an academic research center. Levels of mRNA and protein were examined by RT-qPCR and western blotting, respectively. The accumulation levels of progesterone were measured by enzyme-linked immunosorbent assay (ELISA). TGF-β1 treatment downregulated StAR expression and decreased progesterone production. The suppressive effects of TGF-β1 on StAR expression and progesterone production were abolished by the inhibition of TGF-β type I receptor. In addition, treatment with TGF-β1 activated the Smad2/3 and ERK1/2 signaling pathways. The inhibition of the Smad3 and ERK1/2 signaling pathways attenuated the TGF-β1-induced downregulation of StAR expression and progesterone production. TGF-β1 downregulated StAR expression and decreased progesterone production by activating the Smad3 and ERK1/2 signaling pathways in human granulosa cells.

  11. The direction of cloud computing for Malaysian education sector in 21st century

    Science.gov (United States)

    Jaafar, Jazurainifariza; Rahman, M. Nordin A.; Kadir, M. Fadzil A.; Shamsudin, Syadiah Nor; Saany, Syarilla Iryani A.

    2017-08-01

    In 21st century, technology has turned learning environment into a new way of education to make learning systems more effective and systematic. Nowadays, education institutions are faced many challenges to ensure the teaching and learning process is running smoothly and manageable. Some of challenges in the current education management are lack of integrated systems, high cost of maintenance, difficulty of configuration and deployment as well as complexity of storage provision. Digital learning is an instructional practice that use technology to make learning experience more effective, provides education process more systematic and attractive. Digital learning can be considered as one of the prominent application that implemented under cloud computing environment. Cloud computing is a type of network resources that provides on-demands services where the users can access applications inside it at any location and no time border. It also promises for minimizing the cost of maintenance and provides a flexible of data storage capacity. The aim of this article is to review the definition and types of cloud computing for improving digital learning management as required in the 21st century education. The analysis of digital learning context focused on primary school in Malaysia. Types of cloud applications and services in education sector are also discussed in the article. Finally, gap analysis and direction of cloud computing in education sector for facing the 21st century challenges are suggested.

  12. Control and autonomy between headquarters and subsidiaries: a case study of a us multinational in Portugal

    Directory of Open Access Journals (Sweden)

    Manuel Portugal Ferreira

    2013-11-01

    Full Text Available The management of multinational corporations (MNCs is complicated by the dispersion of subsidiaries in different locations, and the need to organize the best solutions for control, coordination and independence of each subsidiary to leverage their contribution to the EMN. In this article, based on the case study of a U.S. MNC with a subsidiary in Portugal, we analyze the relationship between autonomy and control headquarters the Portuguese subsidiary. The study identifies the main reasons that determine the amount of control exercised over the subsidiary. We conclude that the centralization, formalization of processes and integration rules are essential to the maintenance of coordination and cooperation between headquarters and subsidiary. However, it is the performance of the subsidiary and its role, particularly as contributory network of subsidiaries, which seems to confine the relations of control-autonomy.

  13. Promoting the 21st century scientific literacy skills through innovative chemistry instruction

    Science.gov (United States)

    Rahayu, Sri

    2017-12-01

    Students need to be equipped with the 21st century skills/capabilities to ensure their competitiveness in the knowledge era. So, it is imperative that education at school should be changed in order to fulfill the need. However, there is not any specified approach on how to educate young students for the 21st century capabilities. Regardless the impediment for ts exist, we need to construct an innovative instruction that can develop the students' 21st century skills by incorporating the skills needed, based on contemporary theory of learning, necessary context of learning and appropriate assessment in a chemistry subject matter. This paper discuss the feasible skills to be promoted through chemistry course. Those skills/capabilities are scientific literacy, higher order thinking, communicationand collaboration and curiosity. The promoted are called the 21st century scientific literacy skills in which it emphasis on scientific literacy and embedded the other 21st century skills into the innovative chemistry instruction. The elements involve in the instruction such as inquiry and constructivist approach, nature of science, contemporary/socioscientific issues, critical thinking (higher order thinking).

  14. Developing 21st century skills in chemistry classrooms: Opportunities and challenges of STEAM integration

    Science.gov (United States)

    Hadinugrahaningsih, Tritiyatma; Rahmawati, Yuli; Ridwan, Achmad

    2017-08-01

    The paper portrays the first year of two-year study in integration Science, Technology, Engineering, Art, and Mathematics (STEAM) in chemistry learning. The research focused on developing 21st-century skills of chemistry students in secondary schools. The 21st-century skills as a set of abilities that students need to develop in facing the future challenge which involves learning, literacy, and life skills. The study was conducted in two secondary schools both public and private school in topics of hydrocarbon, petroleum, solubility, and acid base in year 10 and 11. The qualitative methodology was applied to explore the students' learning experiences and understanding the research context. Data was collected through observation, interview, reflective journal, and 21st-century rubric. The STEAM approach was integrated through modification of project-based learning model. The students had opportunities to develop their own projects by integrating chemistry and STEAM principles to their project. The results show that students have developed their critical and creative thinking, problem-solving skills, collaboration and argumentation skills, leadership and responsibility, information and literacy skills. The researchers faced the challenges of integrating STEAM within the chemistry curricula, empowering students, and managing the teaching and time resources. Students have started to challenge their critical and creative thinking within the existing learning environments. Integrating STEAM into chemistry learning has developed students' 21st-century skills in those three areas. Teachers also learned to develop their competencies for being facilitators and agents of change, in addition to skills development in dealing with students' differences.

  15. Corporate Language and Implications for Organizational Learning

    DEFF Research Database (Denmark)

    Zølner, Mette

    2013-01-01

    This paper explores empirically implications of language use for MNCs’ learning from subsidiaries. Drawing on sociolinguistic literature, the article argues that while employing a single corporate language facilitates quick and direct communication of explicit knowledge, such a language design...... is insufficient to leverage contextually specific and culturally embedded knowledge. This indicates the need for disentangling language and culture. The paper further argues for the need to go beyond national language to consider how prevailing kinds of corporate talk may curb headquarters potential for learning...

  16. Education for Employment in Nigeria in the 21st Century: Some ...

    African Journals Online (AJOL)

    This paper examined education for employment in Nigeria in the 21st Century. This paper therefore looked at the demand of workplace employment skills, learning skills, literacy skills and life skills. This paper concludes by advocating how to teach 21st Century employment skills, how to guarantee gainful employment, and ...

  17. Proceedings of the 1st JAERI symposium on HTGR technologies

    International Nuclear Information System (INIS)

    1990-07-01

    This report was edited as the Proceedings of the 1st JAERI Symposium on HTGR Technologies, - Design, Licensing Requirements and Supporting Technologies -, collecting the 21 papers presented in the Symposium. The 19 of the presented papers are indexed individually. (J.P.N.)

  18. 21st Century-Based Soft Skills: Spotlight on Non-Cognitive Skills in a Cognitive-Laden Dentistry Program

    Science.gov (United States)

    Quieng, Marjorie C.; Lim, Pearly P.; Lucas, Maria Rita D.

    2015-01-01

    Teaching and learning in the 21st century aims to produce students proficient in content knowledge, specific abilities, literacy, numeracy, and technology uses. From these 21st century skills, soft skills were delineated from these learning outcomes; and defined as intra- and interpersonal skills vital for personal development, social…

  19. Status report on roadmap headquarters issue resolution activities

    International Nuclear Information System (INIS)

    1993-01-01

    The Roadmap Project Office (RPO), under the Office of Planning (EM-14), continues to review headquarters (HQ) issues raised by the field in their roadmap documents. Currently, twenty-nine HQ issues are in the ''resolution'' process or are being defined for resolution. The resolution process involves an Environmental Restoration and Waste Management Program (EM) HQ person, the Action Officer (AO), as the leader in the resolution process. The RPO is responsible to EM-14 for reporting on the progress of issue resolution activities and also to provide contractor support to each Action Officer: the contractor support person is identifies as the Issue Resolution Facilitator (IF). Field contacts also are identified for each issue. This document provides current information on HQ issues actively in the ''resolution'' process or being defined for resolution. The issues are primarily institutional rather than technical and mainly involve regulatory, coordination, prioritization, policy and management concerns

  20. 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop: April 5-7, 2011

    International Nuclear Information System (INIS)

    2011-01-01

    The U.S. marine energy industry is actively pursuing development of offshore wind and marine hydrokinetic (MHK) energy systems. Experience in the wind energy sector demonstrates that new technology development requires thorough measurement and characterization of the environmental conditions prevalent at installation sites and of technology operating in the field. Presently, there are no turn-key instrumentation system solutions that meet the measurement needs of the marine energy industry. The 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop brought together technical experts from government laboratories, academia, and industry representatives from marine energy, wind, offshore oil and gas, and instrumentation developers to present and discuss the instrumentation needs of the marine energy industry. The goals of the meeting were to: (1) Share the latest relevant knowledge among technical experts; (2) Review relevant state-of-the-art field measurement technologies and methods; (3) Review lessons learned from recent field deployments; (4) Identify synergies across different industries; (5) Identify gaps between existing and needed instrumentation capabilities; (6) Understand who are the leading experts; (7) Provide a forum where stakeholders from the marine energy industry could provide substantive input in the development of new marine energy field deployable instrumentation packages.

  1. 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop: April 5-7, 2011

    Energy Technology Data Exchange (ETDEWEB)

    2011-10-01

    The U.S. marine energy industry is actively pursuing development of offshore wind and marine hydrokinetic (MHK) energy systems. Experience in the wind energy sector demonstrates that new technology development requires thorough measurement and characterization of the environmental conditions prevalent at installation sites and of technology operating in the field. Presently, there are no turn-key instrumentation system solutions that meet the measurement needs of the marine energy industry. The 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop brought together technical experts from government laboratories, academia, and industry representatives from marine energy, wind, offshore oil and gas, and instrumentation developers to present and discuss the instrumentation needs of the marine energy industry. The goals of the meeting were to: (1) Share the latest relevant knowledge among technical experts; (2) Review relevant state-of-the-art field measurement technologies and methods; (3) Review lessons learned from recent field deployments; (4) Identify synergies across different industries; (5) Identify gaps between existing and needed instrumentation capabilities; (6) Understand who are the leading experts; (7) Provide a forum where stakeholders from the marine energy industry could provide substantive input in the development of new marine energy field deployable instrumentation packages.

  2. Flextime: A Modified Work Force Scheduling Technique for Selected Headquarters Air Force Logistics Command Organizations.

    Science.gov (United States)

    Kimzey, Reed T.; Prince, Samuel M. O.

    The thesis discusses the advantages and disadvantages of one work force scheduling technique--flextime. The authors were interested in determining if a flextime schedule could be put into effect in a governmental organization such as Headquarters Air Force Logistics Command (AFLC). The study objectives were to determine the feasibility,…

  3. Flipped learning: should it replace didactic learning?

    Directory of Open Access Journals (Sweden)

    Osman A

    2017-10-01

    Full Text Available Abdirahman Osman, Seyed Ramin Jalal, Saeed Azizi Faculty of Medicine, St George’s Hospital Medical School, London, UKWe read with great interest the article by Pettit et al1 on the implementation of flipped learning. We wish to offer our perspective as medical students. The study concluded that a combination of lecture-based teaching accompanied with flipped learning activities appealed to most students. We find this response unsurprising. Pettit et al’s1 article documents the reason – the need for a variation in teaching styles for different themes by millennial learners of the modern student community.View the original paper by Pettit and colleagues.  

  4. Promoter polymorphisms of ST3GAL4 and ST6GAL1 genes and associations with risk of premalignant and malignant lesions of the cervix.

    Science.gov (United States)

    Rivera-Juarez, Maria de Los Angeles; Rosas-Murrieta, Nora Hilda; Mendieta-Carmona, Victoriano; Hernandez-Pacheco, Raquel Esneidy; Zamora-Ginez, Irma; Rodea-Avila, Carlos; Apresa-Garcia, Teresa; Garay-Villar, Onix; Aguilar-Lemarroy, Adriana; Jave-Suarez, Luis Felipe; Diaz-Orea, Maria Alicia; Milflores-Flores, Lorena; Reyes-Salinas, Juan Salvador; Ceja-Utrera, Francisco Javier; Vazquez-Zamora, Victor Javier; Vargas-Maldonado, Tomas; Reyes-Carmona, Sandra; Sosa-Jurado, Francisca; Santos-Lopez, Gerardo; Reyes-Leyva, Julio; Vallejo-Ruiz, Veronica

    2014-01-01

    Sialyltransferase gene expression is altered in several cancers, including examples in the cervix. Transcriptional regulation of the responsible genes depends on different promoters. We aimed to determine the association of single-nucleotide polymorphisms in the B3 promoter of the ST3GAL4 gene and the P1 promoter of the ST6GAL1 gene with cervical premalignant lesions or cervical cancer. A blood sample and/or cervical scrapes were obtained from 104 women with normal cytology, 154 with premalignant lesions and 100 with cervical cancer. We also included 119 blood samples of random donors. The polymorphisms were identified by sequencing from PCR products. For the B3 promoter, a fragment of 506 bp (from nucleotide -408 to +98) was analyzed, and for the P1 promoter a 490 bp (-326 to +164) fragment. The polymorphism analysis showed that at SNP rs10893506, genotypes CC and CT of the ST3GAL4 B3 promoter were associated with the presence of premalignant lesions (OR=2.89; 95%CI 1.72-4.85) and cervical cancer (OR=2.23; 95%CI 1.27-3.91). We detected only one allele of each polymorphism in the ST6GAL1 P1 promoter. We did not detect any genetic variability in the P1 promoter region in our study population. Our results suggest that the rs10893506 polymorphism -22C/T may increase susceptibility to premalignant and malignant lesions of the cervix.

  5. Dataset-driven research for improving recommender systems for learning

    NARCIS (Netherlands)

    Verbert, Katrien; Drachsler, Hendrik; Manouselis, Nikos; Wolpers, Martin; Vuorikari, Riina; Duval, Erik

    2011-01-01

    Verbert, K., Drachsler, H., Manouselis, N., Wolpers, M., Vuorikari, R., & Duval, E. (2011). Dataset-driven research for improving recommender systems for learning. In Ph. Long, & G. Siemens (Eds.), Proceedings of 1st International Conference Learning Analytics & Knowledge (pp. 44-53). February,

  6. The Enhancement of Narrative Writing Skills through the Use of Accordion Book for 1st Grade Students in Lesanpuro 1 Elementary School, Malang

    Directory of Open Access Journals (Sweden)

    Ratna Trieka Agustina

    2017-09-01

    Full Text Available Based on the interviews with the 1 st -grade teachers at Lesanpuro 1 Elementary School, it is found that the students have difficulties in writing a narrative story. Due to the learning activity that is not concrete, students tend to have difficulty to produce ideas because the teachers seldom use the help of media and writing example. So, from this study, it is important to do an action by using the accordion book. In this case, teachers become the model of writing by using the accordion book as its media. This research outlines two cycles in the observation. The results from the first cycle revealed that the writing ability of students who are above average is increased by 31,33 % and 37,33 % for the average students, then, as for the students who are considered to be below average, their writing skills are increased by 29 %. Furthermore, the second cycle showed that the writing ability of students who are below average is increased by 41,67 %, average students by 35,67 %, and above average by 39,67 %. Thus, it is expected that the teachers could create an interesting and innovative media so that students will enjoy the learning activity.

  7. What Do We Know About Corporate Headquarters? A Review, Integration, and Research Agenda

    OpenAIRE

    Menz, Markus; Kunisch, Sven; Collis, David J.

    2013-01-01

    During the past five decades, scholars have studied the corporate headquarters (CHQ) - the multidivisional firm's central organizational unit. The purpose of this article is to review the diverse and fragmented literature on the CHQ and to identify the variables of interest, the dominant relationships, and the contributions. We integrate, for the first time, the existing knowledge of the CHQ into an organizing framework. Based on a synthesis of the literature, we identify major shortcomings a...

  8. The Concept Framework of Structural Equation model of Mobile Cloud Learning Acceptance for Higher Education Students in the 21st Century

    Directory of Open Access Journals (Sweden)

    Thanyatorn Amornkitpinyo

    2017-08-01

    Full Text Available This research’s part is in the structural equation model of mobile cloud learning acceptance for higher education students in the 21st century as its objective is to synthesize and design the framework of this model. The methods of this research are divided into 2 parts which are synthesis, combining it to process the mode and designing framework concept. The findings of this research are as the following: 1. Basic digital literacy, Information Quality and Social Cloud are included in the model as the exogenous latent variables. 2. Satisfaction and TAM model (perceived usefulness and perceived ease of use are included as the mediating latent variables. 3. Actual Use is the outcome of the model’s latent variable.

  9. 21st Century Learning Skills Embedded in Climate Literacy Teacher Professional Development

    Science.gov (United States)

    Myers, R. J.; Schwerin, T. G.; Blaney, L.

    2011-12-01

    Trilling and Fadel's "21st Century Learning Skills" defines a vision of how to infuse an expanded set of skills, competencies and flexibilities into the classroom. Among these skills are global awareness, health and environmental literacy. The authors contend that in order for our students to compete, they will need critical thinking and problem solving skills, communication and collaboration, and creativity and innovation. Students will also need to be digital savvy. This poster outlines a program of preparing teachers to implement inquiry-based modules that allow students to exercise hypothetical deductive reasoning to address climate literacy issues such as: the Dust Bowl, thermohaline circulation, droughts, the North Atlantic Oscillation, climate variability and energy challenges. This program is implemented through the Earth System Science Education Alliance. ESSEA supports the educational goal of "attracting and retaining students in science careers" and the associated goal of "attracting and retaining students in science through a progression of educational opportunities for students, teachers and faculty." ESSEA provides long-duration educator professional development that results in deeper content understanding and confidence in teaching global climate change and science disciplines. The target audience for this effort is pre-service and in-service K-12 teachers. The ESSEA program develops shared educational resources - including modules and courses - that are based on NASA and NOAA climate science and data. The program is disseminated through the ESSEA Web site: http://essea.courses.strategies.org. ESSEA increases teachers' access to high-quality materials, standards-based instructional methods and content knowledge. Started in 2000 and based on online courses for K-12 teachers, ESSEA includes the participation of faculty at 45 universities and science centers. Over 3,500 pre- and in-service K-12 teachers have completed ESSEA courses. In addition to 21st

  10. Demonstration Assessment of Light-Emitting Diode Parking Structure Lighting at U.S. Department of Labor Headquarters

    Energy Technology Data Exchange (ETDEWEB)

    Kinzey, Bruce R.; Myer, Michael

    2013-03-01

    This report documents a solid-state lighting (SSL) technology demonstration at the parking structure of the U.S. Department of Labor (DOL) Headquarters in Washington, DC, in which light-emitting diode (LED) luminaires were substituted for the incumbent high-pressure sodium (HPS) luminaires and evaluated for relative light quantity and performance. The demonstration results show energy savings of 52% from the initial conversion of HPS to the LED product. These savings were increased to 88% by using occupancy sensor controls that were ultimately set to reduce power to 10% of high state operation after a time delay of 2.5 minutes. Because of the relatively high cost of the LED luminaires at their time of purchase for this project (2010), the simple payback periods were 6.5 years and 4.9 years for retrofit and new construction scenarios, respectively. Staff at DOL Headquarters reported high satisfaction with the operation of the LED product.

  11. Motivated strategies for learning and their association with academic performance of a diverse group of 1styear medical students

    Directory of Open Access Journals (Sweden)

    Shaista Hamid

    2016-05-01

    Full Text Available Background. Most instruments, including the well-known Motivated Strategies for Learning Questionnaire (MSLQ, have been designed in western homogeneous settings. Use of the MSLQ in health professions education is limited. Objective. To assess the MSLQ and its association with the academic performance of a heterogeneous group of 1st-year medical students. Methods. Eighty-three percent of 1st-year medical students consented to participate in this quantitative study. The MSLQ consisted of a motivation strategies component with six subscales, while the learning strategies component had nine subscales. Demographic and academic achievement information of the students was also collected. Stata version 13 (StataCorp LP, USA was used for the statistical analyses of all data. Results. Female students displayed significantly higher motivational scores. Students with prior educational experience and those who attended peer mentoring sessions had significantly higher learning strategy scores. Significant but moderate relationships were found between academic performance and the motivation strategies subsumed within the categories ‘task value’ and ‘self-efficacy for learning performance’. In terms of the ‘learning strategy component’, ‘critical thinking’, and ‘time and study environment’, the composite score was significantly but poorly correlated to academic performance. Conclusion. Overall, limited correlations were found between the MSLQ scores and academic performance. Further investigation of the use of the MSLQ and its association with academic achievement is recommended, with greater focus on specific learning events than on course outcomes. This study highlights the importance of evaluating an instrument in a specific context before accepting the findings of others with regard to the use of the instrument and its correlation with academic performance.

  12. Variants of ST8SIA1 are associated with risk of developing multiple sclerosis.

    Directory of Open Access Journals (Sweden)

    Seema Husain

    Full Text Available Multiple sclerosis (MS is an inflammatory demyelinating disease of the central nervous system of unknown etiology with both genetic and environmental factors playing a role in susceptibility. To date, the HLA DR15/DQ6 haplotype within the major histocompatibility complex on chromosome 6p, is the strongest genetic risk factor associated with MS susceptibility. Additional alleles of IL7 and IL2 have been identified as risk factors for MS with small effect. Here we present two independent studies supporting an allelic association of MS with polymorphisms in the ST8SIA1 gene, located on chromosome 12p12 and encoding ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1. The initial association was made in a single three-generation family where a single-nucleotide polymorphism (SNP rs4762896, was segregating together with HLA DR15/DQ6 in MS patients. A study of 274 family trios (affected child and both unaffected parents from Australia validated the association of ST8SIA1 in individuals with MS, showing transmission disequilibrium of the paternal alleles for three additional SNPs, namely rs704219, rs2041906, and rs1558793, with p = 0.001, p = 0.01 and p = 0.01 respectively. These findings implicate ST8SIA1 as a possible novel susceptibility gene for MS.

  13. Computer Assisted Language Learning (CALL): Using Internet for Effective Language Learning

    NARCIS (Netherlands)

    Kremenska, Anelly

    2006-01-01

    Please, cite this publication as: Kremenska, A. (2006). Computer Assisted Language Learning (CALL): Using Internet for Effective Language Learning. Proceedings of International Workshop in Learning Networks for Lifelong Competence Development, TENCompetence Conference. March 30th-31st, Sofia,

  14. Intensi Berwirausaha Pada Pelajar Kelas Ekstrakurikuler Kewirausahaan SMAK St. Louis 1 Di Surabaya [The Entrepreneurship Intentions of Entrepreneurship Students in Extracurricular Classes at SMAK St. Louis 1 in Surabaya

    Directory of Open Access Journals (Sweden)

    Gregorius Romaryo Tanubun

    2016-10-01

    Full Text Available The purpose of this research is to understand: (1 the influence of family on entrepreneur intention; (2 the impact of entrepreneurial study on entrepreneur intention; and (3 the difference in entrepreneurial intention among an entrepreneurial class of students at SMAK St. Louis 1 in Surabaya. The population of this research is students of an entrepreneurial class at SMAK St. Louis 1 in  Surabaya. The sampling technique used is census with 40 respondents as samples. This research is a quantitative research with multiple regression method and independent samples t-test with SPSS 23 as analysis tool. The findings of this research indicate that: (1 family variable (K reacts significantly negative towards entrepreneurial intention (IB, (2 entrepreneurial education variable (PK reacts significantly towards entrepreneurial intention (IB, and (3 no difference is found between men and women.

  15. A Teacher Tablet Toolkit to meet the challenges posed by 21st century rural teaching and learning environments

    Directory of Open Access Journals (Sweden)

    Adèle Botha

    2015-11-01

    Full Text Available This article draws upon the experiences gained in participating in an Information and Communication Technology for Rural Education (ICT4RED initiative, as part of a larger Technology for Rural Education project (TECH4RED in Cofimvaba in the Eastern Cape Province of South Africa. The aim of this paper is to describe the conceptualisation, design and application of an innovative teacher professional development course for rural teachers, enabling them to use tablets to support teaching and learning in their classrooms. The course, as outcome, is presented as a Teacher Tablet Toolkit, designed to meet the challenges inherent to the 21st century rural technology enhanced teaching and learning environment. The paper documents and motivates design decisions, derived from literature and adapted through three iterations of a Design Science Research Process, to be incorporated in the ICT4RED Teacher Professional Development Course. The resulting course aims to equip participating teachers with a toolkit consisting of technology hardware, pragmatic pedagogical and technology knowledge and skills, and practice based experience. The significance of game design elements such as simulation and fun, technology in need rather than in case, adequate scaffolding and a clear learning path with interim learning goals are noted.

  16. 1st Applied Electromagnetic International Conference

    CERN Document Server

    Othman, Mohd; Aziz, Mohamad; Malek, Mohd

    2015-01-01

    In this book, experts from academia and industry present the latest advances in scientific theory relating to applied electromagnetics and examine current and emerging applications particularly within the fields of electronics, communications, and computer technology. The book is based on presentations delivered at APPEIC 2014, the 1st Applied Electromagnetic International Conference, held in Bandung, Indonesia in December 2014. The conference provided an ideal platform for researchers and specialists to deliver both theoretically and practically oriented contributions on a wide range of topics relevant to the theme of nurturing applied electromagnetics for human technology. Many novel aspects were addressed, and the contributions selected for this book highlight the relevance of advances in applied electromagnetics to a variety of industrial engineering problems and identify exciting future directions for research.

  17. Joint Force Quarterly. Issue 64, 1st Quarter 2012

    Science.gov (United States)

    2012-01-01

    ndupress .ndu.edu issue 64, 1 st quarter 2012 / JFQ 43 experienced in cultural relativism belie the great commonality of moral solidarity in...Politics of Civil-Military Relations (Cambridge: Harvard University Press, 1957), 11. 12 Many people equate cultural relativism and moral relativism ...perhaps reluctantly, his muse was Platonic (the concept of the human for strategy to work in our age, it must possess solid moral and political

  18. How Recommender Systems in Technology-Enhanced Learning depend on Context

    NARCIS (Netherlands)

    Drachsler, Hendrik; Manouselis, Nikos

    2009-01-01

    Drachsler, H., & Manouselis, N. (2009). How Recommender Systems in Technology-Enhanced Learning depend on Context. Presentation given at the 1st workshop on Context-aware Recommender Systems for Learning at the Alpine Rendez-Vous 2009. November, 30 - December, 3, 2009, Garmisch-Patenkirchen,

  19. CHST14/D4ST1 deficiency: New form of Ehlers-Danlos syndrome.

    Science.gov (United States)

    Kosho, Tomoki

    2016-02-01

    Carbohydrate sulfotransferase 14/dermatan 4-O-sulfotransferase-1 (CHST14/D4ST1) deficiency represents a specific form of Ehlers-Danlos syndrome (EDS) caused by recessive loss-of-function mutations in CHST14. The disorder has been independently termed "adducted thumb-clubfoot syndrome", "EDS, Kosho type", and "EDS, musculocontractural type". To date, 31 affected patients from 21 families have been described. Clinically, CHST14/D4ST1 deficiency is characterized by multiple congenital malformations (craniofacial features including large fontanelle, hypertelorism, short and downslanting palpebral fissures, blue sclerae, short nose with hypoplastic columella, low-set and rotated ears, high palate, long philtrum, thin upper lip vermilion, small mouth, and micro-retrognathia; multiple congenital contractures including adduction-flexion contractures and talipes equinovarus as well as other visceral or ophthalmological malformations) and progressive multisystem fragility-related complications (skin hyperextensibility, bruisability, and fragility with atrophic scars; recurrent dislocations; progressive talipes or spinal deformities; pneumothorax or pneumohemothorax; large subcutaneous hematomas; and diverticular perforation). Etiologically, multisystem fragility is presumably caused by impaired assembly of collagen fibrils resulting from loss of dermatan sulfate (DS) in the decorin glycosaminoglycan side chain that promotes electrostatic binding between collagen fibrils. This is the first reported human disorder that specifically affects biosynthesis of DS. Its clinical characteristics indicate that CHST14/D4ST1 and, more fundamentally, DS, play a critical role in fetal development and maintenance of connective tissues in multiple organs. Considering that patients with CHST14/D4ST1 deficiency develop progressive multisystem fragility-related manifestations, establishment of a comprehensive and detailed natural history and health-care guidelines as well as further elucidation

  20. How sustainable are 1{sup st} and 2{sup nd} generation biofuels for transportation?

    Energy Technology Data Exchange (ETDEWEB)

    Reinhardt, Guido; Hienz, Gunnar [ifeu-Institut fuer Energie- und Umweltforschung GmbH, Heidelberg (Germany)

    2013-06-01

    After the successful implementation of 1{sup st} generation biofuels in the transport sector of several countries all over the world, 2{sup nd} generation biofuels are also being produced in the meantime. Recently, there is a distinct increase in publications on the question and the concerns of many stakeholders whether these biofuels are sustainable and public awareness of this issue is prevalent. This paper summarises the state of the art of the debate whether 1{sup st} and 2{sup nd} generation biofuels are a sustainable alternative for fossil fuels for transportation. Results of several life cycle assessments are compared and conclusions are stated. An environmental assessment identifies the potentials for a sustainable development of biofuels for transportation. Conclusions are that 1{sup st} and 2{sup nd} generation biofuels show both environmental advantages and disadvantages. The analyses of energy and greenhouse gas balances show a wide range of results. Lifecycle assessments and environmental impact assessments provide a method to determine whether biofuels are environmentally sustainable. Impacts on sustainable development are exemplified in the categories land use competition, biomass use competition and CO{sub 2} avoidance costs. Not all biofuels are regarded as being advantageous from an environmental perspective. However, 1{sup st} and 2{sup nd} generation biofuels for transportation show a great potential that needs to be harmonised with other needs (e.g. land for food production or biomass use for industry and chemistry towards an overall sustainable approach). (orig.)

  1. Characterization of a novel telomerase-immortalized human endometrial stromal cell line, St-T1b

    Directory of Open Access Journals (Sweden)

    Brosens Jan J

    2009-07-01

    Full Text Available Abstract Background Coordinated differentiation of the endometrial compartments in the second half of the menstrual cycle is a prerequisite for the establishment of pregnancy. Endometrial stromal cells (ESC decidualize under the influence of ovarian progesterone to accommodate implantation of the blastocyst and support establishment of the placenta. Studies into the mechanisms of decidualization are often hampered by the lack of primary ESC. Here we describe a novel immortalized human ESC line. Methods Primary ESC were immortalized by the transduction of telomerase. The resultant cell line, termed St-T1b, was characterized for its morphological and biochemical properties by immunocytochemistry, RT-PCR and immunoblotting. Its progestational response was tested using progesterone and medroxyprogesterone acetate with and without 8-Br-cAMP, an established inducer of decidualization in vitro. Results St-T1b were positive for the fibroblast markers vimentin and CD90 and negative for the epithelial marker cytokeratin-7. They acquired a decidual phenotype indistinguishable from primary ESC in response to cAMP stimulation. The decidual response was characterized by transcriptional activation of marker genes, such as PRL, IGFBP1, and FOXO1, and enhanced protein levels of the tumor suppressor p53 and the metastasis suppressor KAI1 (CD82. Progestins alone had no effect on St-T1b cells, but medroxyprogesterone acetate greatly enhanced the cAMP-stimulated expression of IGFBP-1 after 3 and 7 days. Progesterone, albeit more weakly, also augmented the cAMP-induced IGFBP-1 production but only after 7 days of treatment. The cell line remained stable in continuous culture for more than 150 passages. Conclusion St-T1b express the appropriate phenotypic ESC markers and their decidual response closely mimics that of primary cultures. Decidualization is efficiently induced by cAMP analog and enhanced by medroxyprogesterone acetate, and, to a lesser extent, by natural

  2. Weather, Climate, Web 2.0: 21st Century Students Speak Climate Science Well

    Science.gov (United States)

    Sundberg, Cheryl White; Kennedy, Teresa; Odell, Michael R. L.

    2013-01-01

    Problem-based learning (PBL) and inquiry learning (IL) employ extensive scaffolding that results in cognitive load reduction and allows students to learn in complex domains. Hybrid teacher professional development models (PDM) using 21st century social collaboration tools embedding PBL and IL shows promise as a systemic approach for increasing…

  3. 33 CFR 100.915 - St. Clair River Classic Offshore Race, St. Clair, MI.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Clair River Classic Offshore Race, St. Clair, MI. 100.915 Section 100.915 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.915 St. Clair River...

  4. The Role of Educational Practice in the Learning of Basic Psychological Concepts (Based on Practical Training of 1st year Master Students Studying “Cultural-Historical Psychology and Activity Approach in Education”

    Directory of Open Access Journals (Sweden)

    Ulanovskaya I. M.

    2015-11-01

    Full Text Available The article describes experience of the practical training for 1st year master students studying «cultural-historical psychology and activity approach in education» entitled “Study of the educational environment of the school”. The basis for training was provided by Moscow school #91 which systematically implemented in the elementary school the program of developing training, developed in the framework of Elkonin-Davydov theory of learning activity. There are examples of tools proposed and developed by teams of master students to evaluate certain characteristics of the educational environment and the results of their use to solve diagnostic problems. It is shown how techniques of deep studying, setting difficult practically significant substantive issues, independent work, group discussions, group projects development and defence, the master students applied, contribute to the formation of the bases of professional critical thinking, reflection and cognitive attitudes.

  5. The Online Learning Knowledge Garden: A Pedagogic Planning Tool for e-Learning

    NARCIS (Netherlands)

    Scott, Bernard

    2006-01-01

    Please, cite this publication as: Scott, B. (2006). The Online Learning Knowledge Garden: A Pedagogic Planning Tool for e-Learning. Proceedings of International Workshop in Learning Networks for Lifelong Competence Development, TENCompetence Conference. March 30th-31st, Sofia, Bulgaria:

  6. Transforming Pedagogies:
Integrating 21st Century Skills And Web 2.0 Technology

    Directory of Open Access Journals (Sweden)

    Shelia Y. TUCKER

    2014-01-01

    Full Text Available According to (P21, Partnership for 21st Century Skills (n.d., unless the gap is bridged between how students learn and how they live, today’s education system will face irrelevance. The way people work and live has been transformed by demographic, economic, political, technological, and informational forces. Schools must adapt to these changing conditions in order to thrive. Students must be equipped to live in a multifaceted, multitasking, technology-driven world. And, regardless of their economic background, we must also ensure that all students have equal access to this new technological world. Collaborative learning theory which is connected to constructivism pedagogy requires students to work together to solve problems. Students need lifelong learning skills i.e., communication and information skills, problem-solving and thinking skills, and interpersonal and self-directional skills. The challenge becomes to deliberately incorporate learning skills into classrooms strategically and broadly. In this digital age, students must learn to use tools essential to everyday life and workplace productivity. They live in a world of almost unlimited streams of profound information, difficult choices and enormous opportunity. Teachers can create a 21st century context for learning by taking students out into the world, by bringing the world into the classroom, and by creating opportunities for students to collaboratively interact with each other (Learning for the, n.d.. One way of accomplishing this task is by employing the use of the Internet to connect Web 2.0 technology and 21st century skills. These skills are essential due to increased global competition, rising workforce capabilities, and accelerated technological change (Learning for the, n.d..

  7. Methicillin-resistant Staphylococcus aureus in Rio de Janeiro hospitals: dissemination of the USA400/ST1 and USA800/ST5 SCCmec type IV and USA100/ST5 SCCmec type II lineages in a public institution and polyclonal presence in a private one.

    Science.gov (United States)

    Caboclo, Roberta Mello Ferreira; Cavalcante, Fernanda Sampaio; Iorio, Natalia Lopes Pontes; Schuenck, Ricardo Pinto; Olendzki, André Nogueira; Felix, Maria José; Chamon, Raiane Cardoso; dos Santos, Kátia Regina Netto

    2013-03-01

    Methicillin-resistant Staphylococcus aureus (MRSA) infections have changed since certain non-multiresistant MRSA lineages have emerged in hospitals. In this study, 99 MRSA isolates, 77 from a public and 22 from a private hospital, were characterized. Isolates were tested for antimicrobial susceptibility, whereas staphylococcal chromosomal cassette mec (SCCmec) typing and Panton-Valentine leukocidin genes were assessed by polymerase chain reaction. Pulsed-field gel electrophoresis and multilocus sequence typing analyses were carried out to determine the MRSA lineages. High rates of resistance were found to erythromycin (96%), ciprofloxacin (93%), and clindamycin (90%). The SCCmec types found were as follows: type II (14.2%), III (62.6%), and IV (23.2%). Approximately 85% of type III isolates was related to the Brazilian epidemic clone in both hospitals. For type IV isolates, 94.4% were related to both USA400/ sequence type (ST) 1 and USA800/ST5 lineages in the public hospital, whereas the USA400/ST1, USA800/ST5, USA1100/ST30, and EMRSA (Epidemic MRSA)-15/ST22 lineages were detected in the private hospital. Among the SCCmec II isolates, approximately 85% were related to the USA100/ST5 lineage. Three MRSA isolates were positive to Panton-Valentine leukocidin genes. The study showed that there was an emergence of USA400/ST1, USA800/ST5 SCCmec IV, and USA100/ST5 SCCmec II MRSA lineages in both hospitals. There was a dissemination of them in the public hospital and a polyclonal presence of the MRSA isolates in the private hospital. The spread of these lineages can be facilitated by the characteristics of the health institution. Copyright © 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

  8. AHEAD OF THE GAME: ADOPTING 21ST CENTURY LEARNING APPROACHES SUPPORTED BY VIDEO-BASED WEB CONFERENCING TECHNOLOGY IN A ROMANIAN PROFESSIONAL TRAINING MILITARY CONTEXT

    Directory of Open Access Journals (Sweden)

    Paula CHARBONNEAU-GOWDY

    2012-01-01

    Full Text Available Recent major political uprisings are indicating the extent to which social learning Web 2.0 technologies, can infl uence change in informal learning settings. Recognition and a discussion of the potential of that infl uence in formal learning settings have only just begun. This article describes a study of an international distance learning project in 2004, using a variety of Web 2.0 technologies, including video-based web conferencing, that sought to initiate and respond to this urgent need for dialogue in the research. Self-selected participants took part in a 5-week English as a foreign language (EFL program, a joint NATO sponsored Canadian and Romanian Ministry of Defense-supported initiative. Clear evidence of linguistic knowledge construction and of important changes to participants’ learner identities, indicates the power of these technologies to support the kind of learning that can lead to the development of global citizens and the skills they will increasingly require in the 21st century.

  9. The greening of the U.S. Department of Energy Headquarters, Washington, D.C. Second-year status report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-22

    The Greening of the Department of Energy Headquarters is a comprehensive, multi-year project designed to identify and implement specific actions DOE can take to save energy and money, improve the comfort and productivity of employees, and benefit the environment. It is part of the Administration`s overall effort to promote greening in all of the nation`s federal buildings. Present Clinton started the Greening of the White House in 1993, and similar efforts have been undertaken by the Department of Defense at the Pentagon, the National Park Service at the Presidio, and now the Department of Energy at the Forrestal and Germantown buildings. The Greening of the Department of Energy Headquarters, An Action Plan for Success (Action Plan), unveiled on April 22, 1996, outlined more than 80 action items for DOE`s Forrestal and Germantown buildings. The action items were designed to increase energy efficiency, improve resource management, improve air quality, reduce water use, reduce paper use, improve landscape management, improve maintenance and operational procedures, increase employee participation, and promote education and outreach. In the two years since the Action Plan was introduced, the Department of Energy has made major progress in implementing specific action items designed to target four major subject areas: (1) Energy Efficiency; (2) Resource Management; (3) Air, Water, Landscape, and (4) Human Factors. This report outlines the status of the recommendations of the Action Plan since they were introduced two years ago.

  10. 33 CFR 334.720 - Gulf of Mexico, south from Choctawhatchee Bay; guided missiles test operations area, Headquarters...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Mexico, south from..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.720 Gulf of Mexico, south from Choctawhatchee Bay; guided missiles test operations area, Headquarters Air Proving...

  11. Introduction of an integrated interactive lecture in the early blocks of 1st year medical students: A pilot study

    Directory of Open Access Journals (Sweden)

    Anudeep Singh

    2016-01-01

    Full Text Available Background: In an integrated curriculum, topics are integrated at the system block level from semester 2 onward. However, in the basic biomedical block, opportunities to integrate also exist which is often overlooked. Aim: A study was conducted to determine the possibility and acceptability of a new pedagogical approach to aid integration of form and function along with the improvement of understanding. Materials and Design: The study was prospective and questionnaire-based, conducted in an upcoming medical college in Malaysia with 1st year medical students. Materials and Methods: An integrated lecture on the autonomic nervous system was planned for the 1st year medical students in their biomedical science block of the first semester by the lecturers from anatomy and physiology and interactive lecture for 1 h and 30 min was delivered. After the session, responses were taken on a structured questionnaire with 10 questions on the Likert scale and a test was conducted to check their understandability. SPSS version 19.1 was used to analyze the results and data were reported based on descriptive statistics and scores were compared by t-test. Results: About 84.2% of the students wanted more lectures of this kind whereas 15.8% disagreed. About 80% stated that proper integration increased their understandability, whereas 83% preferred this modality in comparison to didactic lectures. Conclusions: This pedagogical approach with careful planning can be extended to involve clinical departments thus reaching vertical integration. Including more such integrated interactive sessions will prove to be significant and an effective tool for teaching and learning.

  12. Singapore Technologies Electronics——Committed to Growth in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ About ST Electronics Headquartered in Singapore, ST Electronics has almost 40 years of experience providing electronics, communications and ICT (information communications technologies) solutions to governments and commercial enterprises worldwide.

  13. Singapore Technologies Electronics——Committed to Growth in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ About ST Electronics Headquartered in Singapore,ST Electronics has almost 40 years of experience providing electronics,communications and ICT (information communications technologies) solutions to governments and commercial enterprises worldwide.

  14. Singapore Technologies Electronics——Committed to Growth in China

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ About ST Electronics Headquartered in Singapore,ST Electronics has almost 40 years of experience providing electronics,communications and ICT(information communications technologies)solutions to governments and commercial enterprises worldwide.

  15. Evaluation of Recommender Systems for Technology-Enhanced Learning: Challenges and Possible Solutions

    NARCIS (Netherlands)

    Sandy, Heleau; Drachsler, Hendrik; Gillet, Dennis

    2009-01-01

    Heleou, S., Drachsler, H., & Gillet, D. (2009). Evaluation of Recommender Systems for Technology-Enhanced Learning: Challenges and Possible Solutions. 1st workshop on Context-aware Recommender Systems for Learning at the Alpine Rendez-Vous. November, 30-December, 3, 2009, Garmisch-Patenkirchen,

  16. Proceedings of the 1st CIRP Seminar on Micro and Nano Technology

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Alting, Leo

    2003-01-01

    The present Proceedings of the 1st International CIRP Seminar on Micro and Nano Technology is the result of a CIRP initiative taken by the Working Group on Micro/Nano Technology established in 2002. The CIRP initiative is a recognition of the large potentials that micro/nano technology has...... in improving/enhancing many of the existing products and in forming the basis of a long range of new next generation of products. Micro and nano technology are common phrases used to describe phenomena, components, products etc. related to small dimensions, usually based on functioning principles...... accessible to a large group of customers. Therefore, product development and manufacture is very essential. Therefore this 1st CIRP Seminar represents an important milestone for design and industrial manufacture of products based on micro and nano technology. The Proceedings cover mostly new, interesting...

  17. 21st Summer Farmers’ Market Boasts Quality Goods and Great People | Poster

    Science.gov (United States)

    NCI at Frederick’s 21st summer farmers’ market has officially begun, and this year’s vendors invite all employees to visit, browse their wares, and learn about the benefits of consuming all-natural products. The market is held every Tuesday until October 16 from 10:30 a.m. to 1:00 p.m. outside of Building 549—rain, shine, or, in the case of the most recent Tuesday, snow.

  18. 1st European Conference on Gas Micro Flows (GasMems 2012)

    NARCIS (Netherlands)

    Frijns, A.J.H.; Valougeorgis, D.; Colin, S.; Baldas, L.

    2012-01-01

    PREFACE The aim of the 1st European Conference on Gas Micro Flows is to advance research in Europe and worldwide in the field of gas micro flows as well as to improve global fundamental knowledge and to enable technological applications. Gas flows in microsystems are of great importance and touch

  19. ST2 suppresses IL-6 production via the inhibition of IκB degradation induced by the LPS signal in THP-1 cells

    International Nuclear Information System (INIS)

    Takezako, Naoki; Hayakawa, Morisada; Hayakawa, Hiroko; Aoki, Shinsuke; Yanagisawa, Ken; Endo, Hitoshi; Tominaga, Shin-ichi

    2006-01-01

    LPS induces the production of inflammatory cytokines via the stimulation of Toll-like receptors. In this study, we demonstrated that a soluble secreted form of the ST2 gene product (ST2), a member of the interleukin-1 receptor family, suppressed the production of IL-6 in an LPS-stimulated human monocytic leukemia cell line, THP-1. Immunofluorescence confocal microscopy revealed the binding of ST2 to the surface of the THP-1 cells, in which ST2 led to decreased binding of nuclear factor-κB to the IL-6 promoter. Furthermore, the degradation of IκB in the cytoplasm after LPS stimulation was reduced by pretreatment with ST2. These results demonstrated that ST2 negatively regulates LPS-induced IL-6 production via the inhibition of IκB degradation in THP-1 cells

  20. Decreased Fitness and Virulence in ST10 Escherichia coli Harboring blaNDM-5 and mcr-1 against a ST4981 Strain with blaNDM-5

    Directory of Open Access Journals (Sweden)

    Yawei Zhang

    2017-06-01

    Full Text Available Although coexistence of blaNDM-5 and mcr-1 in Escherichia coli has been reported, little is known about the fitness and virulence of such strains. Three carbapenem-resistant Escherichia coli (GZ1, GZ2, and GZ3 successively isolated from one patient in 2015 were investigated for microbiological fitness and virulence. GZ1 and GZ2 were also resistant to colistin. To verify the association between plasmids and fitness, growth kinetics of the transconjugants were performed. We also analyzed genomic sequences of GZ2 and GZ3 using PacBio sequencing. GZ1 and GZ2 (ST10 co-harbored blaNDM-5 and mcr-1, while GZ3 (ST4981 carried only blaNDM-5. GZ3 demonstrated significantly more rapid growth (P < 0.001 and overgrew GZ2 with a competitive index of 1.0157 (4 h and 2.5207 (24 h. Increased resistance to serum killing and mice mortality was also identified in GZ3. While GZ2 had four plasmids (IncI2, IncX3, IncHI2, IncFII, GZ3 possessed one plasmid (IncFII. The genetic contexts of blaNDM-5 in GZ2 and GZ3 were identical but inserted into different backbones, IncX3 (102,512 bp and IncFII (91,451 bp, respectively. The growth was not statistically different between the transconjugants with mcr-1 or blaNDM-5 plasmid and recipient (P = 0.6238. Whole genome sequence analysis revealed that 28 virulence genes were specific to GZ3, potentially contributing to increased virulence of GZ3. Decreased fitness and virulence in a mcr-1 and blaNDM-5 co-harboring ST10 E. coli was found alongside a ST4981 strain with only blaNDM-5. Acquisition of mcr-1 or blaNDM-5 plasmid did not lead to considerable fitness costs, indicating the potential for dissemination of mcr-1 and blaNDM-5 in Enterobacteriaceae.

  1. iPad Learning Ecosystem: Developing Challenge-Based Learning Using Design Thinking

    Science.gov (United States)

    Marin, Catalina; Hargis, Jace; Cavanaugh, Cathy

    2013-01-01

    In order to maximize college English language students' learning, product development, 21st Century skills and engagement with real world meaningful challenges, a course was designed to integrate Challenge Based Learning (CBL) and iPad mobile learning technology. This article describes the course design, which was grounded in design thinking, and…

  2. An Examination of Mathematically Gifted Students' Learning Styles by Decision Trees/Matematik Alanında Üstün Yetenekli Öğrencilerin Öğrenme Stillerinin Karar Ağaçları Kullanılarak İncelenmesi

    Directory of Open Access Journals (Sweden)

    Esra Aksoy

    2015-12-01

    Full Text Available Abstract The aim of this study was to examine mathematically gifted students' learning styles through data mining method. ‘Learning Style Inventory’ and ‘Multiple Intelligences Scale’ were used to collect data. The sample included 234 mathematically gifted middle school students. The construct decision tree was examined predicting mathematically gifted students’ learning styles according to their multiple intelligences and gender and grade level. Results showed that all the variables used in the study had a significant effect on mathematically gifted students’ learning styles, but the most effective attribute found was intelligence type. Key Words: mathematically gifted students, educational data mining, learning style, multiple intelligences Öz Bu çalışmanın amacı, matematik alanında üstün yetenekli öğrencilerin öğrenme stillerini veri madenciliği yöntemini kullanarak incelemektir. Veri toplama aracı olarak ‘Öğrenme Stili Envanteri’ ve ‘Çoklu Zeka Ölçeği’ kullanılmıştır. Araştırmanın örneklemi, 234 matematik alanında üstün yetenekli ortaokul öğrencisinden oluşmaktadır. Matematik alanında üstün yetenekli öğrencilerin öğrenme stillerini çoklu zeka alanları, cinsiyetleri ve sınıf seviyelerine göre tahmin etmek için oluş- turulan karar ağacı incelenmiştir. Sonuç olarak tüm değişkenlerin üstün yetenekli öğrencilerin öğrenme stilleri üzerinde etkisi olduğu fakat en etkili değişkenin çoklu zeka alanı olduğu gözlenmiştir. Anahtar Sözcükler: matematikte üstün yetenekli öğrenciler, eğitimsel veri madencili- ği, öğrenme stili, çoklu zeka

  3. Rhizomatic Learning: “As… When… and If…” A Strategy for the ASEAN Community in the 21st Century

    Directory of Open Access Journals (Sweden)

    Andrew Lian

    2014-05-01

    Full Text Available The article begins with developments in the ASEAN region. In particular, it focuses on demands generated by the goal to build an ASEAN Community characterized by great diversity amongst member countries. The demands created by this diversity are exacerbated by the immense changes taking place in the 21st century, such as unprecedented richness of information and communication systems, unprecedented mobility and the technological empowerment of ordinary people to create or find their own personal solutions in a just in time, just enough and just for me fashion. This leads to the conclusion that learning needs will be vastly different, individual and largely unpredicted and unpredictable. This realisation implies the necessity to develop adaptable, flexible, yet intellectually coherent learning frameworks which will provide the necessary guidance for creating appropriate learning environments. The article proceeds to construct such a framework on the basis of a five-point analysis of how human perception, understanding and knowledge-construction operate. It then develops a learning structure based on the generation of personal learning environments (PLEs connected to a networked information technology infrastructure which is essentially rhizomatic in nature (i.e. where learners determine the ways that they navigate through information and feedback mechanisms to construct personally-relevant and appropriate knowledge. The article ends with a short scenario to illustrate the workings of this structure and concludes with some remarks about current research in the area in both Asia and Europe

  4. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

  5. Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases.

    Science.gov (United States)

    Wang, X; Zhu, Y F; Li, D M; Qin, Q; Wang, Q; Muhali, F S; Jiang, W J; Zhang, J A

    2016-02-01

    Interleukin 33 (IL33) / ST2 pathway and ST2-interlukin18 receptor1-interlukin18 receptor accessory protein (ST2-IL18R1-IL18RAP) gene cluster have been involved in many autoimmune diseases but few report in autoimmune thyroid diseases (AITD). In this study, we investigated whether polymorphisms of IL33, ST2, IL18R1, and IL18RAP are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITD, among a Chinese population. A total of 11 SNPs were explored in a case-control study including 417 patients with GD, 250 HT patients and 301 controls, including rs1929992, rs10975519, rs10208293, rs6543116, rs1041973, rs3732127, rs11465597, rs1035130, rs2293225, rs1035127, rs917997 of IL 33, ST2-IL18R1-IL18RAP gene cluster. Genotyping of these SNPs was performed using matrix-assisted laser desorption / ionization-time-of-flight mass spectrometer (MALDI-TOF-MS) platform from Sequenom. The frequencies of allele A and AA+AG genotype of rs6543116 (ST2) in HT patients were significantly increased compared with those of the controls (P = 0.029/0.021, OR = 1.31/1.62). And in another SNP rs917997, AA+AG genotype presented an increased frequency in HT subjects compared with controls (P = 0.046, OR = 1.53). Furthermore, the haplotype GAGCCCG from ST2-IL18R1-IL18RAP gene cluster (rs6543116, rs1041973, rs1035130, rs3732127, rs1035127, rs2293225, rs917997) was associated with increased susceptibility to GD with an OR of 2.03 (P = 0.022, 95% CI = 1.07-3.86). Some SNPs of ST2-IL18R1-IL18RAP gene cluster might increase the risk of susceptibility of HT and GD in Chinese Han population. © 2015 John Wiley & Sons Ltd.

  6. Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains.

    Science.gov (United States)

    Kanamori, Hajime; Parobek, Christian M; Juliano, Jonathan J; Johnson, James R; Johnston, Brian D; Johnson, Timothy J; Weber, David J; Rutala, William A; Anderson, Deverick J

    2017-08-01

    Escherichia coli sequence type 131 (ST131) predominates globally among multidrug-resistant (MDR) E. coli strains. We used whole-genome sequencing (WGS) to investigate 63 MDR E. coli isolates from 7 North Carolina community hospitals (2010 to 2015). Of these, 39 (62%) represented ST131, including 37 (95%) from the ST131- H 30R subclone: 10 (27%) from its H 30R1 subset and 27 (69%) from its H 30Rx subset. ST131 core genomes differed by a median of 15 (range, 0 to 490) single-nucleotide variants (SNVs) overall versus only 7 within H 30R1 (range, 3 to 12 SNVs) and 11 within H 30Rx (range, 0 to 21). The four isolates with identical core genomes were all H 30Rx. Epidemiological and clinical characteristics did not vary significantly by strain type, but many patients with MDR E. coli or H 30Rx infection were critically ill and had poor outcomes. H 30Rx isolates characteristically exhibited fluoroquinolone resistance and CTX-M-15 production, had a high prevalence of trimethoprim-sulfamethoxazole resistance (89%), sul1 (89%), and dfrA17 (85%), and were enriched for specific virulence traits, and all qualified as extraintestinal pathogenic E. coli The high overall prevalence of CTX-M-15 appeared to be possibly attributable to its association with the ST131- H 30Rx subclone and IncF[F2:A1:B-] plasmids. Some phylogenetically clustered non-ST131 MDR E. coli isolates also had distinctive serotypes/ fimH types, fluoroquinolone mutations, CTX-M variants, and IncF types. Thus, WGS analysis of our community hospital source MDR E. coli isolates suggested ongoing circulation and differentiation of E. coli ST131 subclones, with clonal segregation of CTX-M variants, other resistance genes, Inc-type plasmids, and virulence genes. Copyright © 2017 American Society for Microbiology.

  7. Singapore Technologies Electronics——Committed to Growth in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ About ST Electronics Headquartered in Singapore,ST Electronics has almost 40 years of experience providing electronics,communications,ICT(Information Communications Technologies)and IT(Information Technologies)solutions to governments and commercial enterorises worldwide.

  8. Differentiation of initial skills in 1st grade and the relative age effect in 3rd grade

    Directory of Open Access Journals (Sweden)

    KRZYSZTOF KONARZEWSKI

    2017-06-01

    Full Text Available The paper aims to verify two hypotheses. The first states that the differentiation of initial 1st grade pupil skills is negatively correlated with age at entry to school. This was tested according to findings from the ERI study Six and seven year olds at the start of school. The variation of reading and writing scores of 1164 pupils aged 5.9–7.9 years who were beginning 1st grade decreased in subsequent age quartiles. The second hypothesis – that classroom differentiation of pupils’ initial skills in 1st grade is positively correlated with the birthdate effect in 3rd grade – was tested on data of 4838 pupils from 254 classrooms drawn from the 2011 PIRLS and TIMSS studies in Poland. Skills were evaluated on the basis of parental reports. Hierarchical linear analysis (gender, SES and school location controlled showed that the greater the differentiation of language skills in 1st grade, the greater the birthdate effect in mathematics in 3rd grade. This result suggests that school entry age is of lesser importance than the methods used to reduce differences in children’s school readiness at the onset of education.

  9. St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1/3 arc-second St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model will be used to support NOAA's tsunami forecast system and for...

  10. About architecture of The Headquarters Building of the First Danube Steamboat Shipping Company in Belgrade

    Directory of Open Access Journals (Sweden)

    Drljević Marija

    2007-01-01

    Full Text Available In this work is represented history and described architecture of The Headquarters Building of The First Danube Steamboat Shipping Company in Belgrade. There is a close regard on the earlier research. The work is as well characterized by the attempt to determine architectural style of building with suggestion that it is a combination of a pure modernism with influences of architecture of communal houses in Vienna from 1919 to 1934.

  11. 2003 - 2004 ACADEMIC TRAINING PROGRAMME 1st TERM

    CERN Multimedia

    Françoise Benz

    2003-01-01

    1st TERM 29 September to 19 December 2003 REGULAR LECTURE PROGRAMME (Renewable) Energy Policy in the EU Members States and the Accession States By D. Reiche, Free University of Berlin, D 13, 14, 15, 16, 17 October LECTURES SERIES FOR POSTGRADUATE STUDENTS Introduction to QCD By B. Webber, CERN-TH 20, 21, 22, 23, 24 October The lectures are open to all those interested, without application. The abstract of the lectures, as well as any change to the above information (title, dates, time, place etc) will be published in the CERN Bulletin, the WWW, and by notices before each term and for each series of lectures.

  12. Students as Learning Designers

    DEFF Research Database (Denmark)

    Levinsen, Karin; Sørensen, Birgitte Holm

    2013-01-01

    This paper focuses on students in the youngest classes at primary school as learning designers of ICT-integrated productions. It is based on the project Netbook 1:1 (2009-2012) funded by the municipality of Gentofte and Microsoft Denmark. The paper presents a model for designing ICT-integrated st......This paper focuses on students in the youngest classes at primary school as learning designers of ICT-integrated productions. It is based on the project Netbook 1:1 (2009-2012) funded by the municipality of Gentofte and Microsoft Denmark. The paper presents a model for designing ICT......-integrated student productions which was developed during the project in relation to different subjects. Ownership, iteration and feedforward are the central concepts in this model. Two exemplary cases are presented illustrating the students’ and teachers’ roles as learning designers in relation to the model...

  13. Proceedings of the 1st conference on nuclear structure data evaluation

    International Nuclear Information System (INIS)

    Firestone, R.B.; Shirley, V.S.; Dairiki, J.M.

    1982-04-01

    The 1st Conference on Nuclear Structure Data Evaluation was organized by the Isotopes Project of the Lawrence Berkeley Laboratory in order to encourage the open discussion of the scientific aspects of ENSDF production and usage. Summaries of the roundtable discussion sessions, abstracts of the presented papers, and additional contributed papers are contained in these Proceedings

  14. Analysis of sustainable leadership for science learning management in the 21st Century under education THAILAND 4.0 framework

    Science.gov (United States)

    Jedaman, Pornchai; Buaraphan, Khajornsak; Pimdee, Paitoon; Yuenyong, Chokchai; Sukkamart, Aukkapong; Suksup, Charoen

    2018-01-01

    This article aims to study and analyze the 21st Century of sustainable leadership under the education THAILAND 4.0 Framework, and factor analysis of sustainable leadership for science learning. The study employed both quantitative and qualitative approaches in collecting data including a questionnaire survey, a documentary review and a Participatory Action Learning (PAL). The sample were sampling purposively. There were 225 administrators of Primary and Secondary Education Area Offices throughout Thailand. Out of 225, 183 (83.33%) and 42 (16.67%) respondents were the administrators of Primary and Secondary Education Offices, respectively. The quantitative data was analyzed by descriptive statistical analysis including mean, standard deviation. Also, the Confirmatory Factor Analysis (CFA) was conducted to analyze the factors associated with sustainable leadership under the education THAILAND 4.0 Framework. The qualitative data was analyzed by using three main stages, i.e., data reduction, data organization, data interpretation to conclusion. The study revealed that sustainable leadership under the education THAILAND 4.0 Framework needs to focus on development, awareness of duty and responsibility, equality, moral and knowledge. All aspects should be integrated together in order to achieve the organizational goals, good governance culture and identity. Importantly, there were six "key" elements of sustainable leadership under the education THAILAND 4.0 framework: i) Professional Leadership Role, ii) Leadership Under Change, iii) Leadership Skills 4.0 in the 21st Century, iv) Development in the Pace With Change, v) Creativity and Creative Tension, and vi) Hold True Assessments. The CFA showed that the six key elements of sustainable leadership under the education THAILAND 4.0 framework by weight of each elements were significant at the .01 significance level.

  15. AIDS. 1st annual George H. Gallup Memorial Survey.

    Science.gov (United States)

    1988-06-01

    Acquired immunodeficiency syndrome (AIDS) was selected as the subject for the 1st annual George H Gallup Memorial Survey. This survey, conducted in August 1987-April 1988 in 35 countries, measured the level of awareness of AIDS, the extent of concern about AIDS, knowledge, changes in behavior resulting form the AIDS epidemic, and attitudes toward people with AIDS. Overall, the poll's findings attest to the effectiveness of the health education efforts of governmental and nongovernmental organizations. Awareness that AIDS poses an urgent international health problem was almost universal in the 35 samples. In about half of these countries, AIDS was identified as the most important national health problem; in the remaining countries, AIDS was ranked 2nd to cancer. The proportion of respondents expressing a fear of personally contracting the AIDS virus ranged from lows of under 10% in most of Europe to a high of 45% among South African blacks. A majority of respondents in the US, Colombia, the Philippines, Brazil, Nigeria, Ecuador, El Salvador, and Chile believed that AIDS will soon spread beyond current risk groups to the general population. Despite widespread awareness of the grave threat posed by AIDS, insufficient numbers of respondents reported that they had made specific behavioral changes intended to protect themselves form HIV infection. Overall, about half of those interviewed indicated they are now more cautious in their choice of sexual partners; similarly, about half are using condoms more or for the 1st time.

  16. Bioethanol Production by Calcium Alginate-Immobilised St1 Yeast System: Effects of Size of Beads, Ratio and Concentration

    Directory of Open Access Journals (Sweden)

    Masniroszaime Md Zain

    2011-12-01

    Full Text Available Immobilized yeast-cell technology posses several advantages in bioethanol production due to its potential to increase the ethanol yield by eliminating unit process used. Thus, process expenses in cell recovery and reutilization can be minimised. The aim of this study is to investigate the influence of three parameters (substrate concentrations, size of alginate beads and ratio of volume of beads to volume of medium on local isolated yeast (ST1 which immobilized using calcium alginate fermentation system. The most affected ethanol production by calcium alginate-immobilised ST1 yeast system were ratio of volume of the beads to the volume of substrate and concentration of LBS. Highest theoretical yield, 78% was obtained in ST1-alginate beads with the size of beads 0.5cm, ratio volume of beads to the volume of LBS media 0.4 and 150g/l concentration of LBS.ABSTRAK: Teknologi sel yis pegun memiliki beberapa kelebihan dalam penghasilan bioetanol kerana ia berpotensi meningkatkan pengeluaran etanol dengan menyingkirkan unit proses yang digunakan. Maka, proses pembiayaan dalam perolehan sel dan penggunaan semula boleh dikurangkan. Tujuan kajian ini adalah untuk mengkaji pengaruh tiga parameter (kepekatan substrat, saiz manik alginat dan nisbah isipadu manik terhadap isipadu bahantara ke atas sel tempatan terasing (local isolated yeast (ST1 yang dipegun menggunakan sistem penapaian kalsium alginat. Penghasilan etanol yang paling berkesan dengan menggunakan sistem yis ST1 kalsium alginat-pegun adalah dengan kadar nisbah isipadu manik terhadap isipadu substrat dan kepekatan LBS. Kadar hasil teori tertinggi iaitu 78% didapati menerusi manik alginat-ST1 dengan saiz manik 0.5cm, nisbah isipadu 0.4 terhadap perantara LBS dan kepekatan LBS sebanyak 150g/l. Normal 0 false false false EN-US X-NONE X-NONE

  17. Assessing 21st Century Skills: A Guide to Evaluating Mastery and Authentic Learning

    Science.gov (United States)

    Greenstein, Laura

    2012-01-01

    The Common Core State Standards clearly define the skills students need for success in college and the 21st century workplace. The question is, how can you measure student mastery of skills like creativity, problem solving, and use of technology? Laura Greenstein demonstrates how teachers can teach and assess 21st century skills using authentic…

  18. Deep Learning

    DEFF Research Database (Denmark)

    Jensen, Morten Bornø; Bahnsen, Chris Holmberg; Nasrollahi, Kamal

    2018-01-01

    I løbet af de sidste 10 år er kunstige neurale netværk gået fra at være en støvet, udstødt tekno-logi til at spille en hovedrolle i udviklingen af kunstig intelligens. Dette fænomen kaldes deep learning og er inspireret af hjernens opbygning.......I løbet af de sidste 10 år er kunstige neurale netværk gået fra at være en støvet, udstødt tekno-logi til at spille en hovedrolle i udviklingen af kunstig intelligens. Dette fænomen kaldes deep learning og er inspireret af hjernens opbygning....

  19. 1st ESMO Consensus Conference in lung cancer; Lugano 2010: small-cell lung cancer

    DEFF Research Database (Denmark)

    Stahel, R; Thatcher, N; Früh, M

    2011-01-01

    , the expert panel prepared clinically relevant questions concerning five areas as follows: early and locally advanced non-small-cell lung cancer (NSCLC), first-line metastatic NSCLC, second-/third-line NSCLC, NSCLC pathology and molecular testing, and small-cell lung cancer (SCLC) to be addressed through......The 1st ESMO Consensus Conference on lung cancer was held in Lugano, Switzerland on 21st and 22nd May 2010 with the participation of a multidisciplinary panel of leading professionals in pathology and molecular diagnostics and medical, surgical and radiation oncology. Before the conference...

  20. 1st ESMO Consensus Conference in lung cancer; Lugano 2010: small-cell lung cancer

    DEFF Research Database (Denmark)

    Stahel, R; Thatcher, N; Früh, M

    2011-01-01

    The 1st ESMO Consensus Conference on lung cancer was held in Lugano, Switzerland on 21st and 22nd May 2010 with the participation of a multidisciplinary panel of leading professionals in pathology and molecular diagnostics and medical, surgical and radiation oncology. Before the conference......, the expert panel prepared clinically relevant questions concerning five areas as follows: early and locally advanced non-small-cell lung cancer (NSCLC), first-line metastatic NSCLC, second-/third-line NSCLC, NSCLC pathology and molecular testing, and small-cell lung cancer (SCLC) to be addressed through...

  1. On Learning Maps

    Science.gov (United States)

    1975-09-01

    Director, Office of Manpower Utilizatic Headquarters, Marine Corps (Code MPU ) MCB (Building 2009) Quantico, VA 22134 1 Dr. A.L. Slafkosky...National Defence HQ Ottawa, Canada K1A OK 2 1 Dr. Alma E. Lantz University of Denver Denver Research Institute Industrial Economics Division

  2. 1st Stage Separation Aerodynamics Of VEGA Launcher

    Science.gov (United States)

    Genito, M.; Paglia, F.; Mogavero, A.; Barbagallo, D.

    2011-05-01

    VEGA is an European launch vehicle under development by the Prime Contractor ELV S.p.A. in the frame of an ESA contract. It is constituted by four stages, dedicated to the scientific/commercial market of small satellites (300 ÷ 2500 kg) into Low Earth Orbits, with inclinations ranging from 5.2° up to Sun Synchronous Orbits and with altitude ranging from 300 to 1500 km. Aim of this paper is to present a study of flow field due to retro-rockets impingement during the 1st stage VEGA separation phase. In particular the main goal of the present work is to present the aerodynamic activities performed for the justification of the separation phase.

  3. Enabling Pedagogy and Andragogy for 21st-Century Sign Language Users and Learners

    Science.gov (United States)

    Hermann-Shores, Patricia

    2017-01-01

    Enabling pedagogy and andragogy is discussed as a form of lifelong learning in which learners attain competences and skills as children (pedagogy) and as adults (andragogy) that enable them to engage in independent learning in the 21st century. Throughout the article the author avoids as much as possible the labels "deaf" and…

  4. Developing 21st Century Process Skills through Project Design

    Science.gov (United States)

    Yoo, Jeong-Ju; MacDonald, Nora M.

    2014-01-01

    The goal of this paper is to illustrate how the promotion of 21st Century process skills can be used to enhance student learning and workplace skill development: thinking, problem solving, collaboration, communication, leadership, and management. As an illustrative case, fashion merchandising and design students conducted research for a…

  5. 76 FR 67671 - Agenda and Notice of Public Meeting of the Connecticut, District of Columbia, Maine, Maryland...

    Science.gov (United States)

    2011-11-02

    ....S.T.). The briefing will be at Commission Headquarters, 624 9th Street NW., Room 540, Washington, DC... are unable to attend the briefing at the Commission Headquarters in person may join through an... Eastern Regional Office, 624 9th Street NW., Suite 740, Washington, DC 20425. Persons wishing to email...

  6. An Interdisciplinary Approach for Biology, Technology, Engineering and Mathematics (BTEM to Enhance 21st Century Skills in Malaysia.

    Directory of Open Access Journals (Sweden)

    Lee Chuo Hiong

    2015-07-01

    Full Text Available An interdisciplinary approach for Biology, Technology, Engineering and Mathematics (BTEM is suggested to develop 21st century skills in the Malaysian context. BTEM allows students to master biological knowledge and at the same time to be adroit in other sub discipline skills. Students master factual knowledge of biology and skills of the 21st century simultaneously. The two main teaching and learning strategies applied in BTEM are problem-based learning and inquiry-based learning. Students are exposed to real world problems that require them to undergo inquiry processes to discover the inventive solutions. The content knowledge of biology adheres to the Malaysian Integrated Curriculum for Secondary Schools. The essence of engineering is inventive problem solving. Incorporation of information communication technologies in teaching and learning will be able to fulfil the needs of the current Net Generation. Mathematics plays an important role as computational tools, especially in analysing data. The highlighted 21st century skills in BTEM include digital literacy, inventive thinking, effective communication, high productivity, and spiritual and noble values.

  7. St. Lucia.

    Science.gov (United States)

    1987-06-01

    The population of St Lucia was 123,000 in 1986, with an annual growth rate of 2%. The infant mortality rate stands at 22.2/1000 live births, and life expectancy is 70.3 years for males and 74.9 years for females. The literacy rate is 78%. St Lucia's labor force is allocated as follows: agriculture, 36.6%; industry and commerce, 20.1%; and services, 18.1%. The gross national product (GNP) was US$146 million in 1985, with an annual growth rate of 3% and a per capita GNP of $1071. St Lucia is a parliamentary democracy modeled on the British Westminster system. The island is divided into 16 parishes and 1 urban area (the capital, Castries). St Lucia is currently a politically stable country, although the high level of youth unemployment is a cause for concern. Ongoing stability may depend on the government's ability to provide services such as jobs and housing. The economy has evolved from a monocrop sugar plantation type to a diversified economy based on agriculture, industry, and tourism. Agriculture, dominated by the banana industry, is characterized by the participation of a large number of small and medium-sized enterprises. Industry is being encouraged through the provision of incentives such as tax rebates. The government is attempting to maintain a sound investment climate through a tripartite dialogue with the private sector and trade unions. Overall economic policy is predicated on the attraction of sound investments, by both local and foreign entities, to accelerate the rate of economic growth, solve the unemployment problem, and generate a solid balance-of-payments position.

  8. The play approach to learning in the context of families and schools: an alternative paradigm for nutrition and fitness education in the 21st century.

    Science.gov (United States)

    Rickard, K A; Gallahue, D L; Gruen, G E; Tridle, M; Bewley, N; Steele, K

    1995-10-01

    An alternative paradigm for nutrition and fitness education centers on understanding and developing skill in implementing a play approach to learning about healthful eating and promoting active play in the context of the child, the family, and the school. The play approach is defined as a process for learning that is intrinsically motivated, enjoyable, freely chosen, nonliteral, safe, and actively engaged in by young learners. Making choices, assuming responsibility for one's decisions and actions, and having fun are inherent components of the play approach to learning. In this approach, internal cognitive transactions and intrinsic motivation are the primary forces that ultimately determine healthful choices and life habits. Theoretical models of children's learning--the dynamic systems theory and the cognitive-developmental theory of Jean Piaget--provide a theoretical basis for nutrition and fitness education in the 21st century. The ultimate goal is to develop partnerships of children, families, and schools in ways that promote the well-being of children and translate into healthful life habits. The play approach is an ongoing process of learning that is applicable to learners of all ages.

  9. An Institutional Autopsy of St. Augustine Junior College

    Science.gov (United States)

    Lumadue, Richard T.

    2009-01-01

    Institutional autopsies can teach much about why learning centers fail the test of time. St. Augustine Junior College in north Florida, the brainchild of Dr. George Apel, was begun in 1942 and ended seven years later in 1949. The purposes of the short-lived college are identified for discussion in this paper. Also identified are the reasons for…

  10. Surveys in 1961 on St. Thomas & St. Croix

    DEFF Research Database (Denmark)

    Dahl, Thorkel; Licht, Kjeld de Fine

    Registration of towns and buildings erected during the Danish reign of the Caribbean Isles of St. Thomas, St. Jan and St. Croix 1671-1917 (now belonging to the USA under the name of Virgin Islands)....

  11. Blended Learning over Two Decades

    Science.gov (United States)

    Zhonggen, Yu; Yuexiu, Zhejiang

    2015-01-01

    The 21st century has witnessed vast amounts of research into blended learning since the conception of online learning formed the possibility of blended learning in the early 1990s. The theme of this paper is blended learning in mainstream disciplinary communities. In particular, the paper reports on findings from the last two decades which looked…

  12. IL-1β Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells.

    Science.gov (United States)

    Dang, Xuan; Zhu, Qinling; He, Yaqiong; Wang, Yuan; Lu, Yao; Li, Xiaoxue; Qi, Jia; Wu, Hasiximuke; Sun, Yun

    2017-10-01

    The proinflammatory cytokine interleukin-1β (IL-1β) may be involved in several ovulation-associated events, such as protease synthesis, prostaglandin production, and steroidogenesis in granulosa cells. However, the exact effect of IL-1β on progesterone synthesis in granulosa cells and the underlying mechanism remain unclear. By using cultured granulosa-lutein cells collected from women undergoing in vitro fertilization or intracytoplasmic sperm injection, we found that IL-1β upregulated steroidogenic acute regulatory protein (StAR) expression and progesterone synthesis in granulosa-lutein cells, which was comparable with luteinizing hormone effect and could be abolished by an IL-1 receptor antagonist. Moreover, IL-1β activated the phosphorylation of cyclic adenosine monophosphate response element-binding protein (CREB), and knockdown of CREB attenuated the induction of StAR expression and progesterone synthesis by IL-1β in granulosa-lutein cells. Furthermore, IL-1β activated the extracellular signal-regulated kinase (ERK)1/2 and p38 pathways and inhibition of the ERK1/2 and p38 pathways attenuated the IL-1β-induced phosphorylation of CREB, StAR expression, and progesterone synthesis in granulosa-lutein cells. In conclusion, IL-1β could upregulate StAR expression and stimulate progesterone biosynthesis through increase in CREB phosphorylation via activating the ERK1/2 and p38 pathways in human granulosa-lutein cells. Copyright © 2017 Endocrine Society.

  13. POD-1/Tcf21 overexpression reduces endogenous SF-1 and StAR expression in rat adrenal cells

    Directory of Open Access Journals (Sweden)

    M. M. França

    2015-12-01

    Full Text Available During gonad and adrenal development, the POD-1/capsulin/TCF21transcription factor negatively regulates SF-1/NR5A1expression, with higher SF-1 levels being associated with increased adrenal cell proliferation and tumorigenesis. In adrenocortical tumor cells, POD-1 binds to the SF-1 E-box promoter region, decreasing SF-1 expression. However, the modulation of SF-1 expression by POD-1 has not previously been described in normal adrenal cells. Here, we analyzed the basal expression of Pod-1 and Sf-1 in primary cultures of glomerulosa (G and fasciculata/reticularis (F/R cells isolated from male Sprague-Dawley rats, and investigated whether POD-1 overexpression modulates the expression of endogenous Sf-1 and its target genes in these cells. POD-1 overexpression, following the transfection of pCMVMycPod-1, significantly decreased the endogenous levels of Sf-1 mRNA and protein in F/R cells, but not in G cells, and also decreased the expression of the SF-1 target StAR in F/R cells. In G cells overexpressing POD-1, no modulation of the expression of SF-1 targets, StAR and CYP11B2, was observed. Our data showing that G and F/R cells respond differently to ectopic POD-1 expression emphasize the functional differences between the outer and inner zones of the adrenal cortex, and support the hypothesis that SF-1 is regulated by POD-1/Tcf21 in normal adrenocortical cells lacking the alterations in cellular physiology found in tumor cells.

  14. Challenges in Strategy and Management of Multinational R&D Centers in Emerging Markets: Perspective from a German Headquarters in the Chemical Sector

    Directory of Open Access Journals (Sweden)

    Osmar Mitsuo Saito

    2013-03-01

    Full Text Available The expansion of multinational company (MNCs operations abroad represents an observed trend for decades. The news is that in recent years the research and development (R&D activities also have become internationalized, including more intensified focus on emerging countries. Among the implications is the challenge for the MNCs to implement effective organizational structures with the intention to facilitate the articulated coordination of strategies and R&D management between the headquarters and their global R&D centers. The purpose of this study is to evaluate the strategy from the perspective of the corporate headquarters of a multinational company and the challenges in the formulation of the global R&D strategy and management of each center located inemerging and developed markets. For this reason, we developed an empirical research based on qualitative multiple case exploratory study in a German chemical MNC company in its five global R&D centers located in Germany (headquarters, USA, Brazil, China and India. The results suggested the needs to creation of organizational management capabilities for constant re-evaluation of its R&D strategy in order to capture the demands and the temporary windows of opportunities from these markets. These capabilities lead to reducing the strong observed centralization level and assigning more responsibilities to the subsidiaries with global R&D center status.

  15. Galleria mellonella infection model demonstrates high lethality of ST69 and ST127 uropathogenic E. coli.

    Directory of Open Access Journals (Sweden)

    Majed F Alghoribi

    Full Text Available Galleria mellonella larvae are an alternative in vivo model for investigating bacterial pathogenicity. Here, we examined the pathogenicity of 71 isolates from five leading uropathogenic E. coli (UPEC lineages using G. mellonella larvae. Larvae were challenged with a range of inoculum doses to determine the 50% lethal dose (LD50 and for analysis of survival outcome using Kaplan-Meier plots. Virulence was correlated with carriage of a panel of 29 virulence factors (VF. Larvae inoculated with ST69 and ST127 isolates (10(4 colony-forming units/larvae showed significantly higher mortality rates than those infected with ST73, ST95 and ST131 isolates, killing 50% of the larvae within 24 hours. Interestingly, ST131 isolates were the least virulent. We observed that ST127 isolates are significantly associated with a higher VF-score than isolates of all other STs tested (P≤0.0001, including ST69 (P<0.02, but one ST127 isolate (strain EC18 was avirulent. Comparative genomic analyses with virulent ST127 strains revealed an IS1 mediated deletion in the O-antigen cluster in strain EC18, which is likely to explain the lack of virulence in the larvae infection model. Virulence in the larvae was not correlated with serotype or phylogenetic group. This study illustrates that G. mellonella are an excellent tool for investigation of the virulence of UPEC strains. The findings also support our suggestion that the incidence of ST127 strains should be monitored, as these isolates have not yet been widely reported, but they clearly have a pathogenic potential greater than that of more widely recognised clones, including ST73, ST95 or ST131.

  16. Stereospecificity (ST) of the microsomal ethanol oxidizing system (MEOS)

    International Nuclear Information System (INIS)

    Alderman, J.; Kato, S.; Lasker, J.; Lieber, C.S.

    1987-01-01

    The ST of MEOS for the ethanol 1R hydrogen has been variously reported as absolute, partial or absent, with free radical involvement postulated in the latter case. To determine both the ST of MEOS and the participation of free radicals in the reaction, they investigated MEOS ST using 1R[1- 3 H] ethanol as substrate. ST is expressed as the fraction of 3 H labeling in acetaldehyde formed, relative to that in ethanol, and ranges from 0.5 to 0. Partial ST was observed using liver microsomes from both rats and hamsters; it significantly decreased after ethanol feeding. 0.1 mM desferrioxamine (dfx) did not increase ST in any of these microsomal preparations while ferric EDTA decreased it, suggesting that ethanol treatment induces a cytochrome P-450 with lower ST rather than increasing free radical involvement. This is supported by a virtual absence of ST observed in a reconstituted system containing purified hamster P-450/sub ALC/, a liver cytochrome P-450 isozyme induced in hamsters by ethanol treatment. Their results indicate that, unlike other enzymes that oxidize ethanol, MEOS has only partial ST. Thus, ST alone cannot be used as an index of free radical involvement but, when evaluated with the response of ST to dfx, it indicated that MEOS is unlikely to involve free radical attack on ethanol in solution

  17. Developing 21st Century Chemistry Learning through Designing Digital Games

    Science.gov (United States)

    Lay, Ah-Nam; Osman, Kamisah

    2018-01-01

    The purpose of this study is to investigate the effect of Malaysian "Kimia" (Chemistry) Digital Games (MyKimDG) module on students' achievement and motivation in chemistry as well as 21st century skills. Chemistry education in Malaysia should put greater emphasis on combination of cognitive, sociocultural and motivational aspects to…

  18. Learning Lunar Science Through the Selene Videogame

    Science.gov (United States)

    Reese, D. D.; Wood, C. A.

    2010-03-01

    Selene is a videogame to promote and assess learning of lunar science concepts. As players build and modify a Moon, Selene measures learning as it occurs. Selene is a model for 21st century learning and embedded assessment.

  19. Workshop on the Development of the UNESCO Co-Action Learning Centre Programme (1st, Kuala Lumpur, Malaysia, November 12-18, 1992). Final Report.

    Science.gov (United States)

    National Federation of UNESCO Associations in Japan, Tokyo.

    This publication summarizes reports from a workshop to share the experience of UNESCO's literacy program and to learn about other effective experiences in literacy available in the region. The opening of the workshop and election of officers is reported. Summaries of the following reports are given: (1) the role of learning centers to achieve…

  20. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2017

    International Nuclear Information System (INIS)

    2017-01-01

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2017. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  1. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2015

    International Nuclear Information System (INIS)

    2015-01-01

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2015. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  2. IG Statement: Arthur A. Elkins, Jr., on OIG report Early Warning Report: Main EPA Headquarters Warehouse in Landover, Maryland, Requires Immediate EPA Attention

    Science.gov (United States)

    Statement of Inspector General Arthur A. Elkins, Jr., on the Office of Inspector General (OIG) report Early Warning Report: Main EPA Headquarters Warehouse in Landover, Maryland, Requires Immediate EPA Attention.

  3. Bathymetry 1M GRID of St. John (South Shore - Area 1), US Virgin Islands, 2004, UTM 20 WGS84

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains an ESRI Grid with 1 meter cell size representing the bathymetry of the south shore of St. John, US Virgin Islands. Due to the large file size...

  4. Reading for Learning: Literacy Supports for 21st-Century Work

    Science.gov (United States)

    Gomez, Louis M.; Gomez, Kimberley

    2007-01-01

    The U.S. work force is changing. Professional and related occupations and service occupations will be the fastest-growing sectors for the foreseeable future. Both demand strong communication skills for sharing complex ideas across diverse communities. In addition, the 21st-century economy will require its members to think creatively and critically…

  5. Fostering 21st Century Skills through Game Design and Development

    Science.gov (United States)

    Garvey, Gregory P.

    2015-01-01

    This reflection paper argues that the design and development of digital games teach essential 21st century skills. Intrinsic to application and game development is design thinking. Design thinking requires iterative development, which demands creativity, critical thinking and problem solving. Students are engaged through learning by doing in both…

  6. 77 FR 14777 - Notice of Commission Staff Attendance

    Science.gov (United States)

    2012-03-13

    ... Southern Company Services, Inc.: 2012 Southeastern Regional Transmission Planning Process (SERTP) 1st..., 2012, 9 a.m.-5 p.m., Local Time The above-referenced meeting will be held at: Alabama Power Company Corporate Headquarters, Room 4H, Birmingham, Alabama The above-referenced meeting is open to stakeholders...

  7. Overexpression of StNF-YB3.1 reduces photosynthetic capacity and tuber production, and promotes ABA-mediated stomatal closure in potato (Solanum tuberosum L.).

    Science.gov (United States)

    Xuanyuan, Guochao; Lu, Congming; Zhang, Ruofang; Jiang, Jiming

    2017-08-01

    Nuclear factor Y (NF-Y) is one of the most ubiquitous transcription factors (TFs), comprising NF-YA, NF-YB and NF-YC subunits, and has been identified and reported in various aspects of development for plants and animals. In this work, StNF-YB3.1, a putative potato NF-YB subunit encoding gene, was isolated from Solanum tuberosum by rapid amplification of cDNA ends (RACE). Overexpression of StNF-YB3.1 in potato (cv. Atlantic) resulted in accelerated onset of flowering, and significant increase in leaf chlorophyll content in field trials. However, transgenic potato plants overexpressing StNF-YB3.1 (OEYB3.1) showed significant decreases in photosynthetic rate and stomatal conductance both at tuber initiation and bulking stages. OEYB3.1 lines were associated with significantly fewer tuber numbers and yield reduction. Guard cell size and stomatal density were not changed in OEYB3.1 plants, whereas ABA-mediated stomatal closure was accelerated compared to that of wild type plants because of the up-regulation of genes for ABA signaling, such as StCPK10-like, StSnRK2.6/OST1-like, StSnRK2.7-like and StSLAC1-like. We speculate that the acceleration of stomatal closure was a possible reason for the significantly decreased stomatal conductance and photosynthetic rate. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Italian research on Antarctic atmosphere: 1st workshop. Ricerche italiane sull'atmosfera antartica: 1o workshop

    Energy Technology Data Exchange (ETDEWEB)

    Colacino, M. (ed.); Giovannelli, G. (ed.); Stefanutti, L. (ed.)

    1989-01-01

    The papers and reports, presented at this 1st workshop on 'Italian research on antarctic atmosphere', deal with several main topics: meteorology and climatology, aerosol and tropospheric clouds, planetary boundary layer, chemical-physic stratospheric property, aeronomy. They define the stage of development of Italian research in this area after 3 years of activity in Antarctica.

  9. The Agency's permanent headquarters in the Donaupark

    International Nuclear Information System (INIS)

    1975-01-01

    Early in 1967 the Government of Austria announced to the Board of Governors that it was making offers to the IAEA and UNIDO to establish Permanent Headquarters on 'the Donaupark site' to include office buildings, conference rooms required for the performance of the organizations' functions, as well as buildings for common services. The site of 160,000 square meters on the banks of the Danube River is 7 km from the centre of Vienna An International Architects' Competition was held in 1969. The Federal Government selected the plans of Architect Johann Staber in December 1970 and commissioned him with the work. A company, the IAKW (Internationales Amtssitzund Konferenzzentrum Wien AG), was founded in May 1971 and charged with the administrative, financial, and co-ordinating functions for the entire project. The construction of the office towers began in April 1973 and the shell of these towers was completed in the spring of 1975, the completed facades having already been placed on certain towers during that time. The conference building and the common services buildings are presently under construction. Completion of the whole complex is scheduled for the latter part of 1978 and work is progressing according to schedule. The actual building costs for the whole project are estimated at 6.8 billion Austrian schillings with an additional 6.2 billion schillings financing cost, and are shared between the Federal Government (65%) and the City of Vienna (35%); in addition, the City of Vienna has provided the land. Included in the total costs are the costs for traffic lanes within and leading to the area

  10. Proceedings of the 1st symposium on advanced science research

    International Nuclear Information System (INIS)

    1995-09-01

    The 1st symposium on advanced science research was held in Tokai-mura, Ibaraki-ken, on 23-24 March, 1995, under the auspices of JAERI. Two hundred and sixty scientists attended the symposium; over 40% of the attendants were from universities and laboratories outside JAERI. This proceedings consists of 6 oral presentations of the research activities in the Advanced Science Research Center, 70 poster presentations on the field of basic science from both the inside and outside of JAERI and 2 panel discussions on the actinide physics and biocrystallography. (author)

  11. Differences in symptoms, first medical contact and pre-hospital delay times between patients with ST- and non-ST-elevation myocardial infarction.

    Science.gov (United States)

    Ängerud, Karin H; Sederholm Lawesson, Sofia; Isaksson, Rose-Marie; Thylén, Ingela; Swahn, Eva

    2017-11-01

    In ST-elevation myocardial infarction, time to reperfusion is crucial for the prognosis. Symptom presentation in myocardial infarction influences pre-hospital delay times but studies about differences in symptoms between patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction are sparse and inconclusive. The aim was to compare symptoms, first medical contact and pre-hospital delay times in patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction. This multicentre, observational study included 694 myocardial infarction patients from five hospitals. The patients filled in a questionnaire about their pre-hospital experiences within 24 h of hospital admittance. Chest pain was the most common symptom in ST-elevation myocardial infarction and non-ST-elevation myocardial infarction (88.7 vs 87.0%, p=0.56). Patients with cold sweat (odds ratio 3.61, 95% confidence interval 2.29-5.70), jaw pain (odds ratio 2.41, 95% confidence interval 1.04-5.58), and nausea (odds ratio 1.70, 95% confidence interval 1.01-2.87) were more likely to present with ST-elevation myocardial infarction, whereas the opposite was true for symptoms that come and go (odds ratio 0.58, 95% confidence interval 0.38-0.90) or anxiety (odds ratio 0.52, 95% confidence interval 0.29-0.92). Use of emergency medical services was higher among patients admitted with ST-elevation myocardial infarction. The pre-hospital delay time from symptom onset to first medical contact was significantly longer in non-ST-elevation myocardial infarction (2:05 h vs 1:10 h, p=0.001). Patients with ST-elevation myocardial infarction differed from those with non-ST-elevation myocardial infarction regarding symptom presentation, ambulance utilisation and pre-hospital delay times. This knowledge is important to be aware of for all healthcare personnel and the general public especially in order to recognise symptoms suggestive of ST-elevation myocardial infarction and

  12. Asymptomatic ST-depression during exercise testing in children and adolescents with type 1 diabetes mellitus and autonomic dysfunction

    Directory of Open Access Journals (Sweden)

    Dmitry Nikitich Laptev

    2015-04-01

    Full Text Available Aim. The aim of this study was to investigate cardiac autonomic function as assessed by ST dynamics during and post-exercise in children and adolescents with type 1 diabetes mellitus (T1DM. Materials and methods. The study included 71 young patients with T1DM. The patients were aged 9?18 years and had no history of macrovascular disease or renal disease, including microalbuminuria. Cardiac autonomic function was assessed using cardiovascular tests and 24-h ECG monitoring with automatic calculation of QT interval and heart rate variability parameters. Each patient underwent the physical working capacity 170 test. Results. The prevalence of cardiovascular autonomic neuropathy (CAN was 30.9%. The frequency of asymptomatic ST-segment depression increased during exercise in 10 (45.5% patients with CAN (CAN+ compared with 9 (18.4% patients without CAN (CAN-; p=0.042. During the recovery period, asymptomatic ST-segment depression was present in the first minute in 8 (36.4% CAN+ patients compared with 1 (2% CAN- patient (p=0.0003 and in the second minute in 5 (22.7% CAN+ patients compared with 1 (2% CAN- patient (p=0.0095. Conclusion. Children and adolescents with T1DM and impaired autonomic function have increased prevalence of asymptomatic ST-segment depression during and post-exercise. The presence of cardiovascular risk factors in children and adolescents with T1DM and CAN may contribute to the increased cardiovascular morbidity and mortality during adulthood in patients with T1DM.

  13. Asymptomatic ST-depression during exercise testing in children and adolescents with type 1 diabetes mellitus and autonomic dysfunction

    Directory of Open Access Journals (Sweden)

    Dmitry Nikitich Laptev

    2015-04-01

    Full Text Available Aim. The aim of this study was to investigate cardiac autonomic function as assessed by ST dynamics during and post-exercise in children and adolescents with type 1 diabetes mellitus (T1DM.Materials and methods. The study included 71 young patients with T1DM. The patients were aged 9–18 years and had no history of macrovascular disease or renal disease, including microalbuminuria. Cardiac autonomic function was assessed using cardiovascular tests and 24-h ECG monitoring with automatic calculation of QT interval and heart rate variability parameters. Each patient underwent the physical working capacity 170 test.Results. The prevalence of cardiovascular autonomic neuropathy (CAN was 30.9%. The frequency of asymptomatic ST-segment depression increased during exercise in 10 (45.5% patients with CAN (CAN+ compared with 9 (18.4% patients without CAN (CAN-; p=0.042. During the recovery period, asymptomatic ST-segment depression was present in the first minute in 8 (36.4% CAN+ patients compared with 1 (2% CAN- patient (p=0.0003 and in the second minute in 5 (22.7% CAN+ patients compared with 1 (2% CAN- patient (p=0.0095.Conclusion. Children and adolescents with T1DM and impaired autonomic function have increased prevalence of asymptomatic ST-segment depression during and post-exercise. The presence of cardiovascular risk factors in children and adolescents with T1DM and CAN may contribute to the increased cardiovascular morbidity and mortality during adulthood in patients with T1DM.

  14. Doing science in order to communicate about science from 1st course of ESO: learning to think, to read, to make, to communicate and to write science

    Directory of Open Access Journals (Sweden)

    María del Pilar Menoyo Díaz

    2017-01-01

    Full Text Available This  article  presents  the  project  \\Doing  science  in  order  to  communicate  about  science  from  1st  course of ESO : learning to think, to read, to make to communicate and to write science", awarded with “Ethics and Science for schools" second price in 2015 by the Foundation Victor Grífols i Lucas. The project's aim is twofold: the first one is that students gradually achieve during the whole ESO's itinerary a high-quality scientific alphabetization from all the areas and thus acquiring scientific and linguistic competencies that qualify  them  to  ask  themselves  questions  that  can  be  answered  through  by  research.  Its  second  goal  is  to encourage  students  to  ethically  process  sources  of  information  and  data  gathering  as  well  as  to  make  a sustainable use of the available resources. Communication and external dissemination of the process and results of the research is encouraged in two main ways. The first one, is achieved by using Juan Manuel Zafra  high-school's  website  as  teaching-learning  tool:  both  in  the  private  area  (Moodle  and  the  public area (with an on-line magazine, news, tweets and blogs. Moreover, students are encouraged to participate in  young  researchers  meetings,  as  Exporecerca  Jove,  Jóvenes  Investigadores,  Galiciencia  among  others research seminars. This article propounds a progression of the scientific and linguistic competences along the  four  courses  of  ESO  as  well  as  proposing  frames  in  which  the  student  body  can  be  initiated  in  the research process.

  15. Assessing the effect of an online HIV/AIDS course on 1st-year ...

    African Journals Online (AJOL)

    Background. More international HIV/AIDS intervention initiatives targeting young adults are needed to help reach targets set by the Joint United Nations Programme on HIV and AIDS (UNAIDS). Objectives. To determine the effect of an online HIV/AIDS course on 1st-year pharmacy students' knowledge of HIV prevention and ...

  16. Leading Learning in Our Times

    Science.gov (United States)

    Trilling, Bernie

    2010-01-01

    Important tools that schools need to support a 21st century approach to teaching and learning include the usual suspects: the Internet, pen and paper, cell phones, educational games, tests and quizzes, good teachers, caring communities, educational funding, and loving parents. All of these items and more contribute to a 21st century education, but…

  17. EDUCATION REFORMS TOWARDS 21ST CENTURY SKILLS: TRANSFORMING STUDENTS' LEARNING EXPERIENCES THROUGH EFFECTIVE LEARNING ENVIRONMENTS

    OpenAIRE

    Harriet Wambui Njui

    2018-01-01

    This paper reviews literature on learning environments with a view to making recommendations on how teachers could create effective and high-quality learning environments that provide learners with transformative learning experiences as they go through the process of education. An effective learning environment is critical because quality education, which is essential to real learning and human development, is influenced by factors both inside and outside the classroom. Learning institutions ...

  18. Identifying Students learning Styles as a Way to Promote Learning Quality

    Directory of Open Access Journals (Sweden)

    Jafar Sadegh Tabrizi

    2013-05-01

    Full Text Available Introduction: The major part of peoples knowledge, skills and abilities are achieved during the complex process called learning. Learning is not simply the product of mere intelligence and capabilities of individual; it also depends on other factors such as personality traits, personal interests, and t ype of duty and di fferent methods and st yles. The understanding of each individual fits with his/her learning style. The aim of this study was to determine the learning st yles of Health Care Management students in Tabriz University of Medical Sciences. Methods: Learning styles of 55 Health Services Management students in Tabriz Health and Nutrition Faculty were evaluated in 2009 using a twelve-question Kolb questionnaire in a descriptive study. The data was anal yzed using SPSS. And the frequency of students learning styles was identified by their ages and averages. Results: In this study, 69% of the students were female and the dominant learning method was Assimilator (42%. Other styles with a regard to their frequency were Diverge (24%, Coverage (22%and Accommodator (12%. In the present study,no statistically significant relationship was found in learning styles between the gender (p= 0.644and average (p = 0.676of the students. Conclusion: Assimilator and Diverge methods were the most common ones among the management students. Hence, to improve the quality of learning in this group of students, it is proposed that the teachers use interactive and creative teaching methods such as small and la rge group discussion,brain storming, problem solving, debate-based learning, self-learning and lecturing.

  19. Challenges to learning and schooling in the digital networked world of the 21st century

    NARCIS (Netherlands)

    Voogt, Joke; Erstad, O.; Dede, C.; Mishra, P.

    2013-01-01

    This article elaborates on the competencies, often referred to as 21st century competencies, that are needed to be able to live in and contribute to our current (and future) society. We begin by describing, analysing and reflecting on international frameworks describing 21st century competencies,

  20. Democracy, cognitive skill, and top 1% income share in the 21st century

    OpenAIRE

    Yamamura, Eiji

    2015-01-01

    Studies to date have shown that income concentration for the top 1% income share, the super-rich, has increased conspicuously in the 21st century. However, there is insufficient knowledge on how political factors and types of human capital influence income concentration. Using cross-country data from this century, I provide empirical evidence that shows that democracy and cognitive skill are negatively correlated to the top 1% income share.

  1. The Importance of Friends: Friendship and Adjustment among 1st-Year University Students

    Science.gov (United States)

    Buote, Vanessa M.; Pancer, S. Mark; Pratt, Michael W.; Adams, Gerald; Birnie-Lefcovitch, Shelly; Polivy, Janet; Wintre, Maxine Gallander

    2007-01-01

    In a study of new friendships and adjustment among 1st-year university students, students at six Canadian universities completed questionnaires that assessed the quality of new friendships and adjustment during their first academic year. In-depth, face-to-face interviews about students' new friendships were conducted with a subsample of these…

  2. 1st Latin American Congress on Automation and Robotics

    CERN Document Server

    Baca, José; Moreno, Héctor; Carrera, Isela; Cardona, Manuel

    2017-01-01

    This book contains the proceedings of the 1st Latin American Congress on Automation and Robotics held at Panama City, Panama in February 2017. It gathers research work from researchers, scientists, and engineers from academia and private industry, and presents current and exciting research applications and future challenges in Latin American. The scope of this book covers a wide range of themes associated with advances in automation and robotics research encountered in engineering and scientific research and practice. These topics are related to control algorithms, systems automation, perception, mobile robotics, computer vision, educational robotics, robotics modeling and simulation, and robotics and mechanism design. LACAR 2017 has been sponsored by SENACYT (Secretaria Nacional de Ciencia, Tecnologia e Inovacion of Panama).

  3. 1st International Conference on Communication and Computer Engineering

    CERN Document Server

    Othman, Mohd; Othman, Mohd; Rahim, Yahaya; Pee, Naim

    2015-01-01

    This book covers diverse aspects of advanced computer and communication engineering, focusing specifically on industrial and manufacturing theory and applications of electronics, communications, computing, and information technology. Experts in research, industry, and academia present the latest developments in technology, describe applications involving cutting-edge communication and computer systems, and explore likely future directions. In addition, access is offered to numerous new algorithms that assist in solving computer and communication engineering problems. The book is based on presentations delivered at ICOCOE 2014, the 1st International Conference on Communication and Computer Engineering. It will appeal to a wide range of professionals in the field, including telecommunication engineers, computer engineers and scientists, researchers, academics, and students.

  4. Developing the 21st-Century Social Studies Skills through Technology Integration

    Science.gov (United States)

    Farisi, Mohammad Imam

    2016-01-01

    Recently, technology has become an educational necessity in global-digital era. Facing these phenomena, social studies (SS) should make innovations related to changes of 21st-century skills and learning paradigm, which is characterized by the principles of disclosure of information, computing, automation, and communication. Technology integration…

  5. Development of a problem - based learning (PBL) and cooperative learning (CL) transportation engineering course For undergraduate students.

    Science.gov (United States)

    2008-08-01

    This study reports the findings of a project that was done during the implementation of a : problem-based learning (PBL) and cooperative learning (CL) elements into an : undergraduate transportation engineering course. The study procedure used the st...

  6. Assessment of Learning in Digital Interactive Social Networks: A Learning Analytics Approach

    Science.gov (United States)

    Wilson, Mark; Gochyyev, Perman; Scalise, Kathleen

    2016-01-01

    This paper summarizes initial field-test results from data analytics used in the work of the Assessment and Teaching of 21st Century Skills (ATC21S) project, on the "ICT Literacy--Learning in digital networks" learning progression. This project, sponsored by Cisco, Intel and Microsoft, aims to help educators around the world enable…

  7. Nondestructive examination of 51 fuel and reflector elements from Fort St. Vrain Core Segment 1

    International Nuclear Information System (INIS)

    Miller, C.M.; Saurwein, J.J.

    1980-12-01

    Fifty-one fuel and reflector elements irradiated in core segment 1 of the Fort St. Vrain High-Temperature Gas-Cooled Reactor (HTGR) were inspected dimensionally and visually in the Hot Service Facility at Fort St. Vrain in July 1979. Time- and volume-averaged graphite temperatures for the examined fuel elements ranged from approx. 400 0 to 750 0 C. Fast neutron fluences varied from approx. 0.3 x 10 25 n/m 2 to 1.0 x 10 25 n/m 2 (E > 29 fJ)/sub HTGR/. Nearly all of the examined elements shrank in both axial and radial dimensions. The measured data were compared with strain and bow predictions obtained from SURVEY/STRESS, a computer code that employs viscoelastic beam theory to calculate stresses and deformations in HTGR fuel elements

  8. Inquiry and 21st-Century Learning

    Science.gov (United States)

    Pappas, Marjorie L.

    2009-01-01

    Over the last eight years, the primary focus in schools has been on passing standardized tests based on a core curriculum. The emphasis on learning content is in direct contrast to the world outside the school walls where the technological capability to provide access to content, i.e., information at lightning speed, already exists. In fact,…

  9. Understanding the Construction of Personal Learning Networks to Support Non-Formal Workplace Learning of Training Professionals

    Science.gov (United States)

    Manning, Christin

    2013-01-01

    Workers in the 21st century workplace are faced with rapid and constant developments that place a heavy demand on them to continually learn beyond what the Human Resources and Training groups can meet. As a consequence, professionals must rely on non-formal learning approaches through the development of a personal learning network to keep…

  10. Identification and molecular characterization of Chryseobacterium vrystaatense ST1 isolated from oligomineral water of southeast Serbia

    Directory of Open Access Journals (Sweden)

    Kojić M.

    2012-01-01

    Full Text Available The isolation and molecular characterization of bacterial strains isolated from water sources in the Vlasina Mountain in southeast Serbia, confirmed the presence of a new species Chryseobacterium vrystaatense ST1. This Gram- negative species showed an extremely low level of biochemical reactivity in biochemical tests. The gene for 16S rRNA was amplified by PCR using universal primers and sequenced. Comparison of 16S rRNA gene sequence and phenotypic features indicated that the isolate ST belonged to Chryseobacterium vrystaatense. A BLAST search of sequenced 1088 nucleotides of the 16S rRNA gene with all sequences deposited in the NCBI collection showed the highest similarity (98% with the strain Chryseobacterium vrystaatense sp. nov., designated as strain R-23533. The very high homology of these two strains allowed classification of our strain at the species level, but some differences indicate, and indirectly confirm, that the isolate ST is an authentic representative. On the basis of these results, we could conclude that Chryseobacterium vrystaatense ST was for first time isolated in Serbia, which is particularly important when one bears in mind that there are only three sequences of this species deposited in the NCBI collection.

  11. Unsupervised deep learning reveals prognostically relevant subtypes of glioblastoma.

    Science.gov (United States)

    Young, Jonathan D; Cai, Chunhui; Lu, Xinghua

    2017-10-03

    One approach to improving the personalized treatment of cancer is to understand the cellular signaling transduction pathways that cause cancer at the level of the individual patient. In this study, we used unsupervised deep learning to learn the hierarchical structure within cancer gene expression data. Deep learning is a group of machine learning algorithms that use multiple layers of hidden units to capture hierarchically related, alternative representations of the input data. We hypothesize that this hierarchical structure learned by deep learning will be related to the cellular signaling system. Robust deep learning model selection identified a network architecture that is biologically plausible. Our model selection results indicated that the 1st hidden layer of our deep learning model should contain about 1300 hidden units to most effectively capture the covariance structure of the input data. This agrees with the estimated number of human transcription factors, which is approximately 1400. This result lends support to our hypothesis that the 1st hidden layer of a deep learning model trained on gene expression data may represent signals related to transcription factor activation. Using the 3rd hidden layer representation of each tumor as learned by our unsupervised deep learning model, we performed consensus clustering on all tumor samples-leading to the discovery of clusters of glioblastoma multiforme with differential survival. One of these clusters contained all of the glioblastoma samples with G-CIMP, a known methylation phenotype driven by the IDH1 mutation and associated with favorable prognosis, suggesting that the hidden units in the 3rd hidden layer representations captured a methylation signal without explicitly using methylation data as input. We also found differentially expressed genes and well-known mutations (NF1, IDH1, EGFR) that were uniquely correlated with each of these clusters. Exploring these unique genes and mutations will allow us to

  12. U(1) x U(1) x U(1) symmetry of the Kimura 3ST model and phylogenetic branching processes

    International Nuclear Information System (INIS)

    Bashford, J D; Jarvis, P D; Sumner, J G; Steel, M A

    2004-01-01

    An analysis of the Kimura 3ST model of DNA sequence evolution is given on the basis of its continuous Lie symmetries. The rate matrix commutes with a U(1) x U(1) x U(1) phase subgroup of the group GL(4) of 4 x 4 invertible complex matrices acting on a linear space spanned by the four nucleic acid base letters. The diagonal 'branching operator' representing speciation is defined, and shown to intertwine the U(1) x U(1) x U(1) action. Using the intertwining property, a general formula for the probability density on the leaves of a binary tree under the Kimura model is derived, which is shown to be equivalent to established phylogenetic spectral transform methods. (letter to the editor)

  13. Family affluence, socio - economic status and dietary habits of 1st year University students

    Directory of Open Access Journals (Sweden)

    Eirini Syligardou

    2016-03-01

    Full Text Available Introduction: Low socio-economic status (SES is associated with health risk behaviours contributing to the social inequalities in health. However, the associations of dietary habits with socio-economic status have not been investigated in emerging adulthood in detail yet. Aim: To investigate the associations of dietary habits with socio-economic status in 1st year undergraduate university students. Methods: This cross-sectional analysis draws data from the LATO study, a longitudinal study of all 1st year undergraduate students of TEI Crete during the academic year 2012/13 (Ν=1138, 54% girls, Mean age 18,31 years, response rate 96,7%. The consumption frequencies of fruits, vegetables, soft drinks, breakfast and delivery food were associated with the following socio-economic indicators: Family affluence (FAS II, paternal and maternal educational level and self-reported economic status. The SPSS v21.0 was used to perform logistic regression models after adjusting for potential confounders. Results: Only 24,9%, 12% and 17% of the students were consuming breakfast, fruits and vegetables, respectively, in a daily basis. Soft drinks were consumed daily by 6,1% of the participants but most of them consumed delivery/junk food less than 1/week (73,8%. Higher family affluence was associated with increased odds of consuming breakfast (OR=2,90, 95%CI=1,13-7,44, soft drinks (OR=8,10, 95%CI=1,38-47,68 and delivery/junk food (OR=2,44, 95%CI=1,27-4,70 in boys. High paternal educational level was associated in a protective way with boys’ consumption of delivery food (OR=0,42, 95%CI=0,18-0,95 and soft drinks (OR=0,19, 95%CI=0,05-0,72. Fruits and vegetables consumption was not associated with any SES indicator. Conclusions: The majority of 1st year university students were not following current diet recommendations irrespective of SES. Interventions targeting eating behaviours are needed at higher education institutes.

  14. Innovative Collaborative Learning Strategies for Integrated Interactive E-Learning in the 21st Century

    Science.gov (United States)

    Son, Barbara

    2016-01-01

    There is a constant challenge for online programs, instructional designers and instructors to tailor eLearning materials for different learning styles. We examined this issue by closely looking at the innovative interactive learning models at the previous AACE Conferences (Son & Goldstone, 2011, Son & Goldstone, 2012, Son & Simonian,…

  15. Coupling between Metacognition and Emotions during STEM Learning with Advanced Learning Technologies: A Critical Analysis, Implications for Future Research, and Design of Learning Systems

    Science.gov (United States)

    Azevedo, Roger; Mudrick, Nicholas; Taub, Michelle; Wortha, Franz

    2017-01-01

    Metacognition and emotions play a critical role in learners' ability to monitor and regulate their learning about 21st-century skills related to science, technology, engineering, and mathematics (STEM) content while using advanced learning technologies (ALTs; e.g., intelligent tutoring systems, serious games, hypermedia, augmented reality). In…

  16. The 21st Century Skills and Job Performance of Teachers

    Science.gov (United States)

    Pa-alisbo, Mark Anthony Cenas

    2017-01-01

    The Philippines' Department of Education through the implementation of the Basic Education Sector Reform Agenda (BESRA) is pursuing a package of policy reforms to further improve education. One of its reforms is the K-12 Program which has opened the way to the mandated 21st Century Skills. These include Learning and Innovation; Information, Media…

  17. Critical Thinking Skills for Rehabilitation Professionals in the 21st Century

    Science.gov (United States)

    Lewis, Allen N.; King, Eric S.; Pitt, Jenelle S.; Getachew, Almaz; Shamburger, Aisha

    2010-01-01

    Critical thinking (CT) is an essential tool for rehabilitation professionals in the 21st century. Well developed CT skills are indicated for rehabilitation professionals in the new century to promote continuous quality improvement of the service delivery system. Such improvement will occur as rehabilitation professionals learn to routinely…

  18. 1st Fire Behavior and Fuels Conference: Fuels Management-How to Measure Success

    Science.gov (United States)

    Patricia L. Andrews

    2006-01-01

    The 1st Fire Behavior and Fuels Conference: Fuels Management -- How to Measure Success was held in Portland, Oregon, March 28-30, 2006. The International Association of Wildland Fire (IAWF) initiated a conference on this timely topic primarily in response to the needs of the U.S. National Interagency Fuels Coordinating Group (http://www.nifc.gov/).

  19. Perceptual Narrowing of Linguistic Sign Occurs in the 1st Year of Life

    Science.gov (United States)

    Palmer, Stephanie Baker; Fais, Laurel; Golinkoff, Roberta Michnick; Werker, Janet F.

    2012-01-01

    Over their 1st year of life, infants' "universal" perception of the sounds of language narrows to encompass only those contrasts made in their native language (J. F. Werker & R. C. Tees, 1984). This research tested 40 infants in an eyetracking paradigm and showed that this pattern also holds for infants exposed to seen language--American Sign…

  20. ST Elevation in aVR with Coexistent Multilead ST Depression

    Directory of Open Access Journals (Sweden)

    Benjamin Cooper

    2017-01-01

    Full Text Available History of present illness: An 80-year-old female with a history of Crohn’s disease presented to the emergency department with chest pain. She had two weeks of exertional chest pain that preceded an episode of chest pain immediately prior to arrival associated with diaphoresis. Her pain nearly completely resolved with sublingual nitroglycerin provided by pre-hospital personnel. She was hemodynamically stable with normal vital signs on arrival. An ECG was immediately obtained. Significant findings: The ECG shows ST-segment depressions in precordial leads V3 through V6, and limb leads I, II, and aVL, and 1 mm of ST-segment elevation in aVR. The initial troponin I was elevated at 1.37 ng/mL (upper limit of normal 0.40. Cardiology decided to delay catheterization until the next day when diffuse coronary disease was discovered (including 90% of the left circumflex stenosis, 60% proximal and 75% mid-left anterior descending stenosis, 75% third diagonal branch stenosis, and 90% posterior descending artery stenosis. The following day, the patient went to the operating room for coronary artery bypass grafting (CABG. Discussion: Traditionally, lead aVR has not received attention when interpreting acutely ischemic changes on ECG, leading some to refer to it as “the forgotten lead.”1 Current guidelines acknowledge the significance of multilead ST depression with coexistent ST elevation in aVR, and this pattern has been identified as the strongest predictor of severe left main coronary artery and/or 3-vessel disease (LM/3VD.2-3 When this ECG pattern is recognized in patients with ischemic symptoms, the emergency physician should involve cardiology early. When managing patients with suspected LM/3VD, it is important to withhold dual anti-platelet therapy as CABG is likely to be indicated,1,3 and guidelines recommend discontinuing P2Y12 inhibitors like clopidogrel or ticagrelor at least 24 hours prior to urgent CABG.2

  1. Challenges to Learning and Schooling in the Digital Networked World of the 21st Century

    Science.gov (United States)

    Voogt, J.; Erstad, O.; Dede, C.; Mishra, P.

    2013-01-01

    This article elaborates on the competencies, often referred to as 21st century competencies, that are needed to be able to live in and contribute to our current (and future) society. We begin by describing, analysing and reflecting on international frameworks describing 21st century competencies, giving special attention to digital literacy as one…

  2. Peter St. John | NREL

    Science.gov (United States)

    St. John Photo of Peter St. John Peter St. John Researcher III-Chemical Engineering Peter.StJohn @nrel.gov | 303-384-7969 Orcid ID http://orcid.org/0000-0002-7928-3722 Education Peter St. John received his engineering from the University of California at Santa Barbara in 2015. During his Ph.D., St. John applied

  3. Bathymetry 1m GRID of St. Thomas, US Virgin Islands, 2004, UTM 20 WGS84

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains an ESRI Grid with 1 meter cell size representing the bathymetry of the south shore of St. Thomas, US Virgin Islands. NOAA's NOS/NCCOS/CCMA...

  4. ST6Gal1, Cox-2 and HB-EGF mRNA Expression in Breast Cancer

    Directory of Open Access Journals (Sweden)

    Aliakbar Taherian

    2015-01-01

    Full Text Available Background: ST6Gal1, Cox-2 and HB-EGF genes are involved in different tumors and their enhanced expressions often correlate with poor prognosis. In this study we assay the expressions of these genes by reverse transcriptase-PCR in 54 breast cancer samples. Methods: Tissue samples were either formalin-fixed for histopathological examination or frozen for reverse transcriptase-PCR. Image program was used for the densitometry of the image of the gels and the expression of different genes was normalized with beta actin expression. The student's t-test and correlation matrix were used for data analyses. Results: We observed significantly higher expressions of ST6Gal1 (P= 0.040, Cox- 2 (P= 0.001 and HB-EGF (P= 0.009 in the tumor region compared to the margin samples. A significant correlation was found between HB-EGF and Cox-2 expression (P= 0.001. There was a positive correlation between total score, tumor size, histology grade and nuclear grade but there was a reverse correlation between age and tumor size, histology grade and total score. Conclusion: Expressions of ST6Gal1, Cox-2 and HB-EGF in breast tumor samples in this and a number of other studies emphasize their role as important markers in breast cancer. The use of medications to inhibit either their individual expressions or the possible inhibition of all three genes may improve patient survival and prevent metastasis.

  5. Social and moral norm differences among Portuguese 1st and 6th year medical students towards their intention to comply with hand hygiene.

    Science.gov (United States)

    Roberto, Magda S; Mearns, Kathryn; Silva, Silvia A

    2012-01-01

    This study examines social and moral norms towards the intention to comply with hand hygiene among Portuguese medical students from 1st and 6th years (N = 175; 121 from the 1st year, 54 from the 6th year). The study extended the theory of planned behaviour theoretical principles and hypothesised that both subjective and moral norms will be the best predictors of 1st and 6th year medical students' intention to comply with hand hygiene; however, these predictors ability to explain intention variance will change according to medical students' school year. Results indicated that the subjective norm, whose referent focuses on professors, is a relevant predictor of 1st year medical students' intention, while the subjective norm that emphasises the relevance of colleagues predicts the intentions of medical students from the 6th year. In terms of the moral norm, 6th year students' intention is better predicted by a norm that interferes with compliance; whereas intentions from 1st year students are better predicted by a norm that favours compliance. Implications of the findings highlight the importance of role models and mentors as key factors in teaching hand hygiene in medical undergraduate curricula.

  6. 1st International Conference on Advancements of Medical Electronics

    CERN Document Server

    Bag, Sandip; Ganguly, Karabi; Sarkar, Indranath; Biswas, Papun

    2015-01-01

    The book is a collection of peer-reviewed scientific papers submitted by active researchers in the 1st International Conference on Advancements of Medical Electronics (ICAME2015). The conference is organized jointly by the Department of Biomedical Engineering and Electronics and Communication Engineering, JIS College of Engineering, West Bengal, India. The primary objective of the conference is to strengthen interdisciplinary research and its applications for the welfare of humanity. A galaxy of academicians, professionals, scientists, statesman and researchers from different parts of the country and abroad got together and shared their knowledge. The book presents research articles of medical image processing & analysis, biomedical instrumentation & measurements, DSP & clinical applications, embedded systems & its applications in healthcare. The book can be referred as a tool for further research.

  7. 21ST-CENTURY TEACHERS: THE STUDENTS’ PERSPECTIVES

    Directory of Open Access Journals (Sweden)

    Maida Norahmi

    2017-03-01

    Full Text Available The issues regarding the demands of creative, innovative, and professional teachers are certainly on the concern of stakeholders and practitioners in education. Substantial efforts were conducted by the government to meet the 21st-century teachers having the four competencies required for being a teacher and coping with the needs of modern education. A survey research was conducted to collect respondents’ opinion as the main source of data to describe whether the 21st-century teachers are on the demands and to gain information that the students have a similar perception to teacher’s competencies required by the government. Seventy-five questionnaires related to the competencies were given to students of English Education Study Program of 2013 to 2016. The questionnaires were aimed at collecting written information dealing with what the students perceived towards the activities implemented by teachers in the process of teaching and learning. The result of questionnaire analysis revealed that most students expected the 21st-century teachers to have skills in teaching and in connecting it with the development of today’s technology and today’s student characteristics. The data also showed that the students constructed the same characteristics of teacher’s competencies required by the government regarding pedagogy, personality, sociality, and professionality.

  8. NOAA TIFF Image - 1m Multibeam Bathymetry, US Virgin Islands - St. John Shelf - Project NF-10-03 - (2010), UTM 20N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a GeoTIFF with 1x1 meter cell size representing the bathymetry of St. John Shelf, a selected portion of seafloor south of St. John, USVI,...

  9. If F(ST) does not measure neutral genetic differentiation, then comparing it with Q(ST) is misleading. Or is it?

    Science.gov (United States)

    Edelaar, Pim; Björklund, Mats

    2011-05-01

    The comparison between neutral genetic differentiation (F(ST) ) and quantitative genetic differentiation (Q(ST) ) is commonly used to test for signatures of selection in population divergence. However, there is an ongoing discussion about what F(ST) actually measures, even resulting in some alternative metrics to express neutral genetic differentiation. If there is a problem with F(ST) , this could have repercussions for its comparison with Q(ST) as well. We show that as the mutation rate of the neutral marker increases, F(ST) decreases: a higher within-population heterozygosity (He) yields a lower F(ST) value. However, the same is true for Q(ST) : a higher mutation rate for the underlying QTL also results in a lower Q(ST) estimate. The effect of mutation rate is equivalent in Q(ST) and F(ST) . Hence, the comparison between Q(ST) and F(ST) remains valid, if one uses neutral markers whose mutation rates are not too high compared to those of quantitative traits. Usage of highly variable neutral markers such as hypervariable microsatellites can lead to serious biases and the incorrect inference that divergent selection has acted on populations. Much of the discussion on F(ST) seems to stem from the misunderstanding that it measures the differentiation of populations, whereas it actually measures the fixation of alleles. In their capacity as measures of population differentiation, Hedrick's G'(ST) and Jost's D reach their maximum value of 1 when populations do not share alleles even when there remains variation within populations, which invalidates them for comparisons with Q(ST) . © 2011 Blackwell Publishing Ltd.

  10. The Role of St Johns Wort (Hypericum Perforatum and Orphanin Interaction on Depression Treatment

    Directory of Open Access Journals (Sweden)

    Sena Yalcin

    2015-12-01

    Full Text Available St. John's Wort (Hypericum perforatum/ Cantarion has been well-studied which has been showed to have antidepressant, antiviral, and antibacterial effects. St Johns Wort gained popularity as an alternative treatment for mild to moderate depression. On the other hand, the neuropeptide, orphanin FQ/nociceptin (OFQ/N, is expressed in both neuronal and non-neuronal tissue. In the brain, OFQ/N has been investigated in relation to stress, anxiety, learning and memory, and addiction. The purpose opf this article is to review the current pharmacological, and clinical papers on St. John's wort, to provide information on orphanin FQ/nociceptin and finally to evaluate probable interaction between two. [Archives Medical Review Journal 2015; 24(4.000: 531-541

  11. Games-to-teach or games-to-learn unlocking the power of digital game-based learning through performance

    CERN Document Server

    Chee, Yam San

    2016-01-01

    The book presents a critical evaluation of current approaches related to the use of digital games in education. The author identifies two competing paradigms: that of games-to-teach and games-to-learn. Arguing in favor of the latter, the author advances the case for approaching game-based learning through the theoretical lens of performance, rooted in play and dialog, to unlock the power of digital games for 21st century learning. Drawing upon the author’s research, three concrete exemplars of game-based learning curricula are described and discussed. The challenge of advancing game-based learning in education is addressed in the context of school reform. Finally, future prospects of and educational opportunities for game-based learning are articulated. Readers of the book will find the explication of performance theory applied to game-based learning especially interesting. This work constitutes the author’s original theorization. Readers will derive four main benefits: (1) an explication of the differenc...

  12. Perception of 1 st year medical students towards career choices and specialty of psychiatry

    Directory of Open Access Journals (Sweden)

    Suneet Kumar Upadhyaya

    2015-01-01

    Full Text Available Background: Shortage of psychiatrists is a worldwide phenomenon. If the factors that attract or repel students towards a specialty can be identified, it may be possible to encourage them towards it. Choice of specialty as a career depends on the complex interplay of experiences before, during or after exposure to the specialty. Objectives: The aim was to understand perceptions of 1 st year medical students regarding career choices and the specialty of psychiatry through a cross-sectional questionnaire-based study. Materials and Methods: Perceptions of 137 1 st year medical students from the Government Medical College were recorded using a semi-structured questionnaire. Students provided their opinions about future career choices; perspective of these specialties in terms of financial reward, reputation, work-life balance, challenging aspect, ability to help patients effectively and emotional stability; their preferences in life and interaction with psychiatrist and its impact. Statistical Analysis Used: One-way analysis of variance (ANOVA with post-hoc analysis by Tukey-Kramer test. Results: Surgery was a high priority for 69 (50% while psychiatry was a high priority only for 11 (8%. Surgery was highest for financial reward and reputation, but lowest for work-life balance. Psychiatry had higher emotional stability, however, its the reputation was lower than surgery, medicine, obstetrics and gynaecology and paediatrics. Students preferred reputation (41% over social service opportunities (43%, work-life balance (16%, and high-income (11%. Interaction with psychiatrist increased inclination for psychiatry in 69% (9/13 students. Conclusions: Psychiatry is not a preferred specialty among 1 st year medical students due to its poor reputation.

  13. Anatomical relationship between traditional acupuncture point ST 36 and Omura's ST 36 (True ST 36) with their therapeutic effects: 1) inhibition of cancer cell division by markedly lowering cancer cell telomere while increasing normal cell telomere, 2) improving circulatory disturbances, with reduction of abnormal increase in high triglyceride, L-homocystein, CRP, or cardiac troponin I & T in blood by the stimulation of Omura's ST 36--Part 1.

    Science.gov (United States)

    Omura, Yoshiaki; Chen, Yemeng; Lu, Dominic P; Shimotsura, Yasuhiro; Ohki, Motomu; Duvvi, Harsha

    2007-01-01

    Using Bi-Digital O-Ring Test Resonance Phenomena between 2 identical substances, Omura, Y. succeeded in making the image of the outline of internal organs without use of standard imaging devices since 1982. When he imaged the outline of the stomach on the abdominal wall, a number of the lines came out from upper and lower parts of stomach wall. When the lines were followed, they were very close to the well-known stomach meridians. Subsequently, he found a method of localizing meridians and their corresponding acupuncture points as well as shapes and diameters accurately. At the anatomical location of ST 36 described in traditional textbooks, Omura, Y. found there is no acupuncture point. However, in the close vicinity, there is an acupuncture point which he named as true ST 36 in the mid 1980s, but it is generally known as Omura's ST 36. When the effects of the acupuncture on these 2 locations were compared, Omura's ST 36 (true ST 36) produced very significant well-known acupuncture beneficial effects including improved circulation and blood chemistry, while in the traditional ST 36, the effects were small. In this article, the anatomical relationship between these two acupuncture points, with a short distance of 0.6 approximately 1.5 cm between the centers of these locations, was described. In early 2000, Omura, Y. found Press Needle Stimulation of Omura's ST 36, using "Press-Release" procedure repeated 200 times, 4 times a day to cancer patients reduced high cancer cell telomere of 600-1500ng and high Oncogen C-fos Ab2 and Integrin alpha5beta1 of 100-700ng BDORT units to close to lyg (= 10(-24) g) BDORT units. In addition there was a significant reduction of Asbestos and Hg from cancer cells, while markedly reduced normal cell telomere of lyg was increased to optimally high amounts of 500-530ng BDORTunits. Thus, cancer cells can no longer divide and cancer activity is inhibited. The authors have successfully applied this method for a variety of cancers as well as

  14. Analysis of storm runoff-sediment yield of a 1st order stream basin in ...

    African Journals Online (AJOL)

    Analysis of storm runoff-sediment yield of a 1st order stream basin in Obafemi Awolowo University, Ile-Ife, southwestern Nigeria. ... The findings of this study will aid programme in soil erosion controls designed by the governments and individuals in forested watersheds. Key Words: Storm flow discharge, storm sediment ...

  15. Critical Thinking for 21st-Century Education: A Cyber-Tooth Curriculum?

    Science.gov (United States)

    Higgins, Steve

    2014-01-01

    It is often assumed that the advent of digital technologies requires fundamental change to the curriculum and to the teaching and learning approaches used in schools around the world to educate this generation of "digital natives" or the "net generation". This article analyses the concepts of 21st-century skills and critical…

  16. NOAA ESRI Geotiff- 1m Bathymetry of St. John (South Shore - Area 1), US Virgin Islands, 2004, UTM 20 WGS84

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains an ESRI Geotiff with 1 meter cell size representing the bathymetry of the south shore of St. John, US Virgin Islands. Due to the large file...

  17. Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB.

    Science.gov (United States)

    Lee, Jinwoo; Tong, Tiegang; Takemori, Hiroshi; Jefcoate, Colin

    2015-06-15

    In mouse steroidogenic cells the activation of cholesterol metabolism is mediated by steroidogenic acute regulatory protein (StAR). Here, we visualized a coordinated regulation of StAR transcription, splicing and post-transcriptional processing, which are synchronized by salt inducible kinase (SIK1) and CREB-regulated transcription coactivator (CRTC2). To detect primary RNA (pRNA), spliced primary RNA (Sp-RNA) and mRNA in single cells, we generated probe sets by using fluorescence in situ hybridization (FISH). These methods allowed us to address the nature of StAR gene expression and to visualize protein-nucleic acid interactions through direct detection. We show that SIK1 represses StAR expression in Y1 adrenal and MA10 testis cells through inhibition of processing mediated by CRTC2. Digital image analysis matches qPCR analyses of the total cell culture. Evidence is presented for spatially separate accumulation of StAR pRNA and Sp-RNA at the gene loci in the nucleus. These findings establish that cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  18. A Teacher Tablet Toolkit to meet the challenges posed by 21st ...

    African Journals Online (AJOL)

    The course, as outcome, is presented as a Teacher Tablet Toolkit, designed to meet the challenges inherent to the 21st century rural technology enhanced teaching and learning environment. The paper documents and motivates design decisions, derived from literature and adapted through three iterations of a Design ...

  19. Joint Force Quarterly. Issue 76, 1st Quarter 2015

    Science.gov (United States)

    2015-01-01

    should be a humanist approach that emphasizes the importance of meeting the student’s full range of needs: emotional, spiritual, physical, and...always be calibrated against the Soviet Union’s existential threat. In contrast, the 21st century’s strategic context is much harder to define and

  20. Analysis and evaluation of recent operational experience from the Fort St. Vrain HTGR

    International Nuclear Information System (INIS)

    Moses, D.L.; Lanning, W.D.

    1985-05-01

    The Fort St. Vrain operating experience to be discussed here includes notable safety-related events which have occurred since late 1981 when ORNL was first contracted to provide technical assistance to AEOD. Earlier Fort St. Vrain operating experience through the time of successful full-power testing in November 1981 has been summarized by the licensee and the reactor vendor, GA Technologies, Inc. (GA), in papers presented at several different forums during 1982. In addition, extensive and very useful detailed evaluations of preoperational and startup testing and of the rise-to-power operating experience through completion of the first refueling outage in August 1979 have been compiled into a series of reports under the sponsorship of the Electric Power Research Institute (EPRI). Finally, the US Department of Energy's Fort St. Vrain Improvement Plan provides a summary of the major operational limits which have affected the plant since start-up. The events discussed here are categorized based on the major systems affected, namely, (1) primary system and reactor vessel, (2) electrical systems, and (3) the reactor building. In all cases to be discussed, the lessons to be learned are vigilance and prevention. These lessons translate into the need for the recognition and control of unexpected situations and of their potential for branching effects. At Fort St. Vrain, these lessons are found in the effects of moisture ingress, in the challenges experienced to the supply of essential electrical power, and in controlling the environment of the reactor building. 13 refs

  1. Toll/Interleukin-1 receptor member ST2 exhibits higher soluble levels in type 2 diabetes, especially when accompanied with left ventricular diastolic dysfunction

    Directory of Open Access Journals (Sweden)

    Fousteris Evangelos

    2011-11-01

    Full Text Available Abstract Background Soluble ST2, a member of the of the Toll/IL-1 superfamily, is a novel biomarker with exceptional predictive value in heart failure and myocardial infarction- related mortality as well as in acute dyspneic states. Soluble ST2 is considered a decoy receptor of IL 33 that blocks the protective effects of the cytokine in atherosclerosis and cardiac remodeling. In the present study we investigated the differences in the levels of soluble ST2, BNP and hs-CRP between healthy controls and patients with type 2 diabetes with and without left ventricular diastolic dysfunction. A secondary aim was to investigate correlations between sST2 and other biomarkers of type 2 diabetes, such as HbA1c. Methods 158 volunteers were recruited and underwent a complete Doppler-echocardiographic evaluation of both systolic & diastolic cardiac function. All subjects with ejection fraction Results Patients with type 2 diabetes with (p Conclusions Patients with type 2 diabetes exhibit higher sST2 levels compared to healthy controls. The presence of LVDD in patients with type 2 diabetes is associated with even higher sST2 levels. A significant correlation between glycemic control and sST2 levels was also revealed.

  2. Enhancing student engagement through the affordances of mobile technology: a 21st century learning perspective on Realistic Mathematics Education

    Science.gov (United States)

    Bray, Aibhín; Tangney, Brendan

    2016-03-01

    Several recent curriculum reforms aim to address the shortfalls traditionally associated with mathematics education through increased emphasis on higher-order-thinking and collaborative skills. Some stakeholders, such as the US National Council of Teachers of Mathematics and the UK Joint Mathematical Council, advocate harnessing the affordances of digital technology in conjunction with social constructivist pedagogies, contextual scenarios, and/or approaches aligned with Realistic Mathematics Education (RME). However, it can be difficult to create technology-mediated, collaborative and contextual activities within a conventional classroom setting. This paper explores how a combination of a transformative, mobile technology-mediated approach, RME, and a particular model of 21st century learning facilitates the development of mathematics learning activities with the potential to increase student engagement and confidence. An explanatory case study with multiple embedded units and a pre-experimental design was conducted with a total of 54 students in 3 schools over 25 hours of class time. Results from student interviews, along with pre-test/post-test analysis of questionnaires, suggest that the approach has the potential to increase student engagement with, and confidence in, mathematics. This paper expands on these results, proposing connections between aspects of the activity design and their impact on student attitudes and behaviours.

  3. The cognitive status of stød

    DEFF Research Database (Denmark)

    Clausen, Sara Juul; Kristensen, Line Burholt

    2015-01-01

    marked. Keeping in mind the cross-distribution between phonetic/phonological markedness and distributional patterns, we investigate here whether stød is also related to accent 1 when it comes to cognitive markedness. We present the results of a psycholinguistic study in which participants attended...... for words with non-stød stems, indicating that the cognitive markedness status of stød corresponds to that of accent 2....

  4. Ad Hoc Transient Groups: Instruments for Awareness in Learning Networks

    NARCIS (Netherlands)

    Fetter, Sibren; Rajagopal, Kamakshi; Berlanga, Adriana; Sloep, Peter

    2011-01-01

    Fetter, S., Rajagopal, K., Berlanga, A. J., & Sloep, P. B. (2011). Ad Hoc Transient Groups: Instruments for Awareness in Learning Networks. In W. Reinhardt, T. D. Ullmann, P. Scott, V. Pammer, O. Conlan, & A. J. Berlanga (Eds.), Proceedings of the 1st European Workshop on Awareness and Reflection in

  5. Optimal Learning in Schools--Theoretical Evidence: Part 4 Metacognition

    Science.gov (United States)

    Crossland, John

    2017-01-01

    Parts 1 and 2 in this four-part series of articles (Crossland, 2016, 2017a) discussed the recent research from neuroscience linked to concepts from cognitive development that brought Piaget's theories into the 21st century and showed the most effective provision towards more optimal learning strategies. Part 2 reviewed Demetriou's latest thinking…

  6. 76 FR 77563 - Florida Power & Light Company; St. Lucie Plant, Unit No. 1; Exemption

    Science.gov (United States)

    2011-12-13

    ... level for St. Lucie, Unit 1, from 2700 megawatts thermal (MWt) to 3020 MWt. As part of the LAR, the.... The above LAR referenced a topical report that stated that the proposed methodology for the P-T curves.... ML103560511), which references Combustion Engineering (CE) Owners Group Topical Report CE NPSD-683-A, Revision...

  7. New feedstocks for biofuels. Alternative 1st generation of energy crops; Nieuwe Grondstoffen voor Biobrandstoffen. Alternatieve 1e Generatie Energiegewassen

    Energy Technology Data Exchange (ETDEWEB)

    Elbersen, W. [Agrotechnology and Food Sciences Group, WUR-AFSG, Wageningen (Netherlands); Oyen, L. [Plant Resources of Tropical Africa, WUR-PROTA, Wageningen (Netherlands)

    2009-08-15

    A brief overview is provided of a number of alternative crops that can supply feedstocks for 1st generation biofuels and a brief analysis is conducted of the option for renewable biofuel production. [Dutch] Er wordt een kort overzicht gegeven van een aantal alternatieve gewassen die grondstoffen voor 1e generatie biobrandstoffen kunnen leveren en wordt er een korte analyse gegeven van de mogelijkheid voor duurzame biobrandstofproductie.

  8. Pretreatment with soluble ST2 reduces warm hepatic ischemia/reperfusion injury

    International Nuclear Information System (INIS)

    Yin Hui; Huang Baojun; Yang Heng; Huang Yafei; Xiong Ping; Zheng Fang; Chen Xiaoping; Chen Yifa; Gong Feili

    2006-01-01

    The interleukin-1 receptor-like protein ST2 exists in both membrane-bound (ST2L) and soluble form (sST2). ST2L has been found to play an important regulatory role in Th2-type immune response, but the function of soluble form of ST2 remains to be elucidated. In this study, we report the protective effect of soluble ST2 on warm hepatic ischemia/reperfusion injury. We constructed a eukaryotic expression plasmid, psST2-Fc, which expresses functional murine soluble ST2-human IgG1 Fc (sST2-Fc) fusion protein. The liver damage after ischemia/reperfusion was significantly attenuated by the expression of this plasmid in vivo. sST2-Fc remarkably inhibited the activation of Kupffer cells and the production of proinflammatory mediators TNF-α and IL-6. Furthermore, the levels of TLR4 mRNA and the nuclear translocation of NF-κB were also suppressed by pretreatment with sST2-Fc. These results thus identified soluble ST2 as a negative regulator in hepatic I/R injury, possibly via ST2-TLR4 pathway

  9. [Expression, crystallization and crystallographic study of the 1st IgV domain of human CD96].

    Science.gov (United States)

    Jiang, Wenjing; Zhang, Shuijun; Yan, Jinghua; Guo, Ning

    2013-05-01

    CD96 (Tactile) is an adhesion receptor expressed mainly on activated T cells, NK cells. As a family member of the immunoglobulin-like cell receptor, CD96 consists of three immunoglobulin-like domains (V1, V2/C and C) in the extracellular region. Recent studies have shown that the 1st IgV domain of CD96 (CD96V1) plays an essential role in cell adhesion and NK cell-mediated killing. In this study, the 1st IgV domain of human CD96 (hCD96V1) was cloned and expressed in Escherichia coli (BL21). The soluble protein was obtained by refolding of the hCD96V1 inclusion bodies. From analytical ultracentrifugation, we could predict that CD96 V1 maily exists as dimer with approximate molecular weight of 26.9 kDa. The protein was then successfully crystallized using the sitting-drop vapour-diffusion method. The crystals diffracted to 1.9 angstrom resolution and belonged to space group P21, with unit-cell parameters a = 35.1, b = 69.5, c = 49.6A, alpha=gamma=90 degrees, beta=105.4 degrees.

  10. The ConocoPhillips Center for a Sustainable WE2ST (Water-Energy Education, Science, and Technology): Lessons Learned from an Innovative Research-Education-Outreach Center at Colorado School of Mines

    Science.gov (United States)

    Hogue, T. S.; Blaine, A. C.; Martin, A. C.

    2016-12-01

    The ConocoPhillips Center for a Sustainable WE2ST (Water-Energy Education, Science, and Technology) is a testament to the power of collaboration and innovation. WE2ST began as a partnership between ConocoPhillips (foundation gift) and the Colorado School of Mines (CSM) with the goal of fostering solutions to water-energy challenges via education, research and outreach. The WE2ST center is a training ground for the next generation of water-energy-social scientists and engineers and is a natural fit for CSM, which is known for its expertise in water resources, water treatment technologies, petroleum engineering, geosciences, and hydrology. WE2ST has nine contributing faculty researchers that combine to create a web of expertise on sustainable energy and water resources. This research benefits unconventional energy producers, water-reliant stakeholders and the general public. Areas of focus for research include water sources (quality and quantity), integrated water-energy solution viability and risk, and social-corporate responsibility. The WE2ST Center currently provides annual support for 8-9 Graduate Fellows and 13 Undergraduate Scholars. Top-tier graduate students are recruited nationally and funded similar to an NSF Graduate Research Fellowship (GRF). Undergraduate Scholars are also recruited from across the CSM campus to gain experience in faculty laboratories and on research teams. All WE2ST students receive extensive professional skills training, leadership development, communication skills training, networking opportunities in the water-energy industries, and outreach opportunities in the community. The corner stone of the WE2ST Center is a focus on communication with the public. Both in social science research teams and in general interactions with the public, WE2ST seeks to be "an honest broker" amidst a very passionate and complex topic. WE2ST research is communicated by presentations at technical conferences, talking with people at public gatherings

  11. Cancer incidence among 1st generation migrants compared to native Danes--a retrospective cohort study

    DEFF Research Database (Denmark)

    Nørredam, Marie Louise; Krasnik, A; Pipper, C

    2007-01-01

    STUDY AIMS: To investigate the incidence of cancer among 1st generation migrants compared to native Danes, including time trends in the risk of cancer among migrants. METHODS: A retrospective cohort study design. Migrants were matched 1:4 on age and sex with a Danish born reference population....... The time trends of the study are interesting and a relevant topic for further research....

  12. Federal laboratories for the 21st century

    Energy Technology Data Exchange (ETDEWEB)

    Gover, J. [Sandia National Labs., Albuquerque, NM (United States); Huray, P.G. [Univ. of South Carolina, Columbia, SC (United States)

    1998-04-01

    Federal laboratories have successfully filled many roles for the public; however, as the 21st Century nears it is time to rethink and reevaluate how Federal laboratories can better support the public and identify new roles for this class of publicly-owned institutions. The productivity of the Federal laboratory system can be increased by making use of public outcome metrics, by benchmarking laboratories, by deploying innovative new governance models, by partnerships of Federal laboratories with universities and companies, and by accelerating the transition of federal laboratories and the agencies that own them into learning organizations. The authors must learn how government-owned laboratories in other countries serve their public. Taiwan`s government laboratory, Industrial Technology Research Institute, has been particularly successful in promoting economic growth. It is time to stop operating Federal laboratories as monopoly institutions; therefore, competition between Federal laboratories must be promoted. Additionally, Federal laboratories capable of addressing emerging 21st century public problems must be identified and given the challenge of serving the public in innovative new ways. Increased investment in case studies of particular programs at Federal laboratories and research on the public utility of a system of Federal laboratories could lead to increased productivity of laboratories. Elimination of risk-averse Federal laboratory and agency bureaucracies would also have dramatic impact on the productivity of the Federal laboratory system. Appropriately used, the US Federal laboratory system offers the US an innovative advantage over other nations.

  13. STEM-21CS Module: Fostering 21st Century Skills through Integrated STEM

    Directory of Open Access Journals (Sweden)

    Norhaqikah Mohamad Khalil

    2017-07-01

    Full Text Available Malaysia calls for a society that is highly knowledgeable in the field of Science, Technology, Engineering, and Mathematics (STEM and equipped with 21st century skills to provide professional workforce that can compete globally. The application of a STEM interdisciplinary approach and teaching and learning (T&L strategies such as problem-based and inquiry-based learning are proposed in development of the STEM-21CS Module in order to foster 21st century skills in the existing science curricula. A majority of real-world issues today are interdisciplinary in which they require students to comprehend the need to integrate multiple disciplines to solve them. STEM-21CS Module allows students to master scientific knowledge and subsequently master other disciplinary skills. It is aimed at improving students’ abilities to enrich their knowledge through hands-on and minds-on activities. The field of engineering requires the knowledge of product design and inventive problem solving skills. The integration of information technology in T&L is recommended in meeting the current needs of the Net Generation. Besides that, mathematics plays a vital role in providing computational tools, especially in analysing data. The STEM-21CS Module is expected to nurture 21st century skills such as digital era literacy, inventive thinking, effective communication, high productivity, and spiritual and noble values among Malaysian students.

  14. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2010

    International Nuclear Information System (INIS)

    2010-01-01

    The report on coal mining situation in the Federal Republic of Germany in the 1st quarter 2010 contains the statistical data concerning the following issues: (i) black coal mining: part I: production, resources, accomplishments; employees, part II: marketing and foreign trade; (ii) brown coal mining: part I: production, resources, accomplishments; employees, part II: marketing and foreign trade.

  15. The 1st of April 2470 BC Total Solar Eclipse Seen by the Prophet Ibraheem

    Science.gov (United States)

    Yousef, S. M.

    The Holy Quran describes a phenomenon seen by young Abraham that can only fit a solar eclipse. Two criteria were given for this particular eclipse; first only one planet was seen as soon as it got dark and second no corona was seen. In order to justify the first selection rule, examinations of solar and planetary longitudes for total solar eclipses passing over Babel were carried out. Only the eclipse of the 1st of April 2470 BC meets this condition, as it was only Venus that was seen at that eclipse. The second selection rule was also naturally fulfilled, as Babel happened to be on the border of the totality zone hence no corona was seen, however all the time the moon glistened as Baily's beads. There is no doubt that the prophet Abraham witnessed the 1st of April total solar eclipse that passed over Babel. This will put him about 470 years backward than it was previously anticipated.

  16. Internship report on palliative care at St Catherine's hospice

    OpenAIRE

    Monteiro, Andreia Marlene da Silva

    2016-01-01

    This report, performed in the context of the completion of the masters in Palliative Care, presents the activities and learning experiences that I have acquired during the months of training in the different settings of palliative care. This internship was performed at St Catherine’s Hospice (Inpatient unit, Day hospice and Community team) and with the National Health Service of East Surrey Hospital Specialist Palliative Care Team. Alongside the institutional involvement, internship activitie...

  17. Building Critical Capacities for Leadership Learning.

    Science.gov (United States)

    Torrez, Mark Anthony; Rocco, Melissa L

    2015-01-01

    Cognitive elements of transformational learning, particularly metacognition and critical self-reflection, are discussed as essential considerations for leadership development in the 21st century. The importance of developmentally sequencing leadership-learning experiences and addressing evolving complexities of leadership identity are also explored. © 2015 Wiley Periodicals, Inc., A Wiley Company.

  18. The Content Analysis, Material Presentation, and Readability of Curriculum 2013 Science Textbook for 1st Semester of Junior High School 7th Grade

    Directory of Open Access Journals (Sweden)

    Endik Deni Nugroho

    2017-07-01

    Full Text Available Based on the early observation by researchers of the two Science textbooks 7thGrade about biological material, 1stand 2ndsemester of curriculum 2013, there were errors in the material presentation and legibility. This study aimed to compare and find the contents suitability of the book based on standard of competence and basic competences, readability, materials presentation and supporting material in the science textbook VII grade, 1st and 2nd semester and measured student legibility. This study used a qualitative descriptive approach by using document analysis. The data resources were obtained by using purposive, the data collection was triangulation, data analysis was inductive/qualitative and the results emphasized the meaning. This research results showed that the Integrated Sciences and Sciences textbook 1st and 2nd semester meet the standards of the core competencies and basic competence on the syllabus curriculum 2013 and also meet the books standart. The results of the analysis conducted in misstatement concept and principles and material llustration in the Integrated Science textbook 1st semester were found 5 misstatement concept, for the presentation of the principles and material illustration was found no error. In the book Integrated Sciences there was no delivery errors concept, principle, and material illustration. Science textbook 1st semester found 8 concepts misstatements and 8 illustration material misstatements. In general, Integrated Sciences and Sciences textbooks 1st and 2nd semester are illegibility so not appropriate for students.

  19. IntuiScript a new digital notebook for learning writing in elementary schools: 1st observations

    OpenAIRE

    Girard , Nathalie; Simonnet , Damien; Anquetil , Eric

    2017-01-01

    International audience; IntuiScript is an innovative project that aims for designing a digital notebook dedicated to handwriting learning at primary schools. One of the main goals is to provide children real-time feedback to make them more autonomous. These feedbacks are produced by automatically analysing their drawing, and this online analysis makes possible an adaptation of the pedagogical scenario to each child according to his own difficulties. The IntruiScript project complies with a us...

  20. Learning design for science education in the 21st century

    Directory of Open Access Journals (Sweden)

    Churchill Daniel

    2013-01-01

    Full Text Available Contemporary technological and social developments demand transformation of educational practices. Teachers and schools are no longer fountains of knowledge that fill students with information. Rather, their primarily role is to equip students with new literacies, competencies for productive use of information technology, and sufficient disciplinary-specific bases of conceptual knowledge. This requires changes toward student-centered practices. In such contexts, teachers are designers of learning; therefore lesson planning is replaced with a concept of ‘learning design.’ This paper introduces the RASE (Resources-Activity-Support-Evaluation learning design model developed as a framework to assist teachers in designing learning modules. Central to RASE is the emphasis on the design of activities where students engage in using resources and in the production of artifacts that demonstrate learning. The paper also emphasizes the importance of ‘conceptual models’ as a special type of educational multimedia resource, and its role in assisting learning and application of concepts, as opposed to the ‘information transfer’ models. RASE is beginning to emerge as a powerful framework for transformation of teachers and their traditional practices to contemporary, relevant student-centered practices. The model is also an effective framework for productive uses of information technology in education.

  1. The Learning University.

    Science.gov (United States)

    Patterson, Glenys

    1999-01-01

    As universities make cross-sectoral alliances, various models for integrating postsecondary education into universities arise: contract, brokerage, collaborative, validation, joint program, dual-sector institution, tertiary university, metaphoric, and federal. The integrated, comprehensive university is the learning university of the 21st century.…

  2. Conference report: 1st Medicon Valley Inhalation Symposium.

    Science.gov (United States)

    Lastow, Orest

    2013-02-01

    The 1st Medicon Valley Inhalation Symposium was arranged by the Medicon Valley Inhalation Consortium. It was held at the Medicon Village site, which is the former AstraZeneca site in Lund, Sweden. It was a 1-day symposium focused on inhaled drug delivery and inhalation product development. A total of 90 delegates listened to 15 speakers. The program was organized to follow the value chain of an inhalation product development. The benefits and future opportunities of inhaled drug delivery were discussed together with some new disease areas that can be targeted with inhalation. The pros and cons of the two main formulation types; dry powder and liquid formulations, were discussed by a panel. The different requirements of the drug molecules from a pharmacology, chemical and physical perspective were explained. The modeling of the physics inside an inhaler was demonstrated and the potential strategic benefits of device design were highlighted together with the many challenges of formulation manufacturing. Lung deposition mechanisms and the difficulties of the generic bioequivalence concept were discussed. Using an anatomically correct impactor inlet is a valuable tool in lung deposition predictions and the planning of clinical trials. The management of the biological material generated in clinical studies is key to successful studies.

  3. An early start to STEM education among year 1 primary students through project-based inquiry learning in the context of a magnet

    Science.gov (United States)

    Safiee, N.; Jusoh, Z. M.; Noor, A. M. H. M.; Tek, O. E.; Salleh, S. M.

    2018-01-01

    For the needs of the 21st century, the Government of Malaysia has conceptualized the Malaysia Education Blueprint 2013-2025 which embodies 11 strategic and operational shifts. In Shift 1, it is emphasized that the quality of Science, Technology, Engineering, and Mathematics (STEM) Education will be enhanced. This study employed the mixed-method approach using the “one-group pre-test and post-test design”. Accordingly, this paper describes the pedagogical practice of Project-based Inquiry Learning (PIL) which promotes STEM Education among Year 1 students in the move to progress in tandem with Shift 1. Specifically, using the context of a magnet which has been stipulated in the Primary School Standard Curriculum, Year 1 students experienced the STEM Education through the STEM Pedagogy in which they raised questions upon the presentation of a relevant stimulus (Inquiry Phase), explored the ways in which a train carriage or coach could be assembled by means of recycled materials and magnets (Exploration Phase), designed a train carriage (Design Phase), and ultimately reflected on their inventions (Reflection Phase). The cognitive and affective impacts through the use of this Project-based Inquiry Learning are presented. Implications for the teaching and learning of science are discussed within the context of STEM Education.

  4. The significance of early post-exercise ST segment normalization.

    Science.gov (United States)

    Chow, Rudy; Fordyce, Christopher B; Gao, Min; Chan, Sammy; Gin, Kenneth; Bennett, Matthew

    2015-01-01

    The persistence of ST segment depression in recovery signifies a strongly positive exercise treadmill test (ETT). However, it is unclear if early recovery of ST segments portends a similar prognosis. We sought to determine if persistence of ST depression into recovery correlates with ischemic burden based on myocardial perfusion imaging (MPI). This was a retrospective analysis of 853 consecutive patients referred for exercise MPI at a tertiary academic center over a 24-month period. Patients were stratified into three groups based on the results of the ETT: normal (negative ETT), persistence (positive ETT with >1mm ST segment depression at 1minute in recovery) and early normalization (positive ETT with normalization, while 105 patients met criteria for persistence. The persistence group had a significantly greater SSS (8.48±7.77) than both the early normalization (4.34±4.98, pnormal (4.47±5.31, pnormalization and normal groups were not statistically different and met the prespecified non-inferiority margin (mean difference 0.12, -0.66=lower 95% CI, pnormal and 7.4% of early normalization groups. Among patients with an electrically positive ETT, recovery of ST segment depression within 1minute was associated with a lower SSS than patients with persistence of ST depression beyond 1minute. Furthermore, early ST segment recovery conferred a similar SSS to patients with a negative ETT. These results suggest that among patients evaluated for chest pain with a positive ETT, early recovery of the ST segment during recovery is associated with a significantly less ischemic burden on subsequent MPI and thus may represent a false positive finding in exercise treadmill testing. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Singapore Technologies Electronics——Committed to Growth in China

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ About STElectronics Headquartered in Singapore, ST Electronics has almost 40 years of experience providing electronics, communications and ICT (information communications technologies) solutions to governments and commercial enterprises worldwide.

  6. Optimal Learning in Schools--Theoretical Evidence: Part 3 Individual Differences

    Science.gov (United States)

    Crossland, John

    2017-01-01

    Parts 1 and 2 in this four-part series of articles (Crossland, 2016, 2017) discussed the recent research from neuroscience linked to concepts from cognitive development that brought Piaget's theories into the 21st century and showed the most effective provision towards more optimal learning strategies. Then the discussion moved onto Demetriou's…

  7. Stāstu stāstīšanas izmantošana lasīšanas veicināšanas pasākumos

    OpenAIRE

    Mežjāne, Signe

    2014-01-01

    Bakalaura darba mērķis ir noskaidrot, vai stāstu stāstīšana ir efektīvs lasīšanas veicināšanas paņēmiens bērniem. Pētījuma problēma ir mūsdienu bērnu nevēlēšanās lasīt, lasīšanu varētu veicināt stāstu stāstīšana bibliotēkās. Darbā tiek analizēts stāstu stāstīšanas process atbilstoši bērnu vecumposmam, izmantojot dažādus runas stilus. Teorētiskā bāze ir balstīta uz Lasītāja reakcijas kritikas teoriju un Runas darbības teoriju. Galvenie pētījuma uzdevumi ir noskaidrot, vai Latvijas bibliotē...

  8. Technology Enhanced Learning: Virtual Realities; Concrete Results--Case Study on the Impact of TEL on Learning

    Science.gov (United States)

    Al-Khatib, Hayat

    2011-01-01

    Technology Enhanced Learning is a feature of 21st century education. Innovations in ICT have provided unbound access to information in support of the learning process (APTEL, 2010; Allert et al, 2002; Baldry et al, 2006; Frustenberg et al, 2001; Sarkis, 2010). LMS has been extensively put to use in universities and educational institutions to…

  9. Zen of cloud learning cloud computing by examples on Microsoft Azure

    CERN Document Server

    Bai, Haishi

    2014-01-01

    Zen of Cloud: Learning Cloud Computing by Examples on Microsoft Azure provides comprehensive coverage of the essential theories behind cloud computing and the Windows Azure cloud platform. Sharing the author's insights gained while working at Microsoft's headquarters, it presents nearly 70 end-to-end examples with step-by-step guidance on implementing typical cloud-based scenarios.The book is organized into four sections: cloud service fundamentals, cloud solutions, devices and cloud, and system integration and project management. Each chapter contains detailed exercises that provide readers w

  10. 75 FR 51945 - Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD

    Science.gov (United States)

    2010-08-24

    ...-AA00 Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD AGENCY: Coast Guard, DHS. ACTION... of the St. Mary's River, a tributary of the Potomac River. This action is necessary to provide for.... Navy helicopter located near St. Inigoes, Maryland. This safety zone is intended to protect the...

  11. Expanding CTE Opportunities through Blended Learning

    Science.gov (United States)

    McKinstry, Elizabeth

    2012-01-01

    The global economy, 21st century skills, knowledge society, college and career readiness, digital and project-based learning are all common terms to educators who are expanding their learning environments beyond the classroom to meet the needs of all students. It is common knowledge that the rapid technological advances of this century have…

  12. DECODING OF ACADEMIC CONTENT BY THE 1st GRADE STUDENTS

    Directory of Open Access Journals (Sweden)

    Kamil Błaszczyński

    2017-07-01

    Full Text Available In the paper a comparative study conducted on the 1st grade students of sociology and pedagogy is discussed. The study was focused on the language skills of students. The most important skills tested were the abilities to decode academic content. The study shows that the students have very poor language skills in decoding the academic content on every level of its complexity. They also have noticeable problems with the definition of basic academic terms. The significance of the obtained results are high because of the innovative topic and character of the study, which was the first such study conducted on students of a Polish university. Results are also valuable for academic teachers who are interested in such problems as effective communication with students.

  13. Influence of the 1st, 2nd and 3rd harmonic magnetic field in mini-cyclotron

    International Nuclear Information System (INIS)

    Lu xiangshun; Chen Maobai; Li Deming; Xu Senlin

    1996-01-01

    The influence of the 1st, 2nd and 3rd harmonic magnetic field on particle's movement in the mini-cyclotron has been studied. The permitted upper limits for each harmonic part are calculated. These data provide a theoretical reference for magnetic trimming

  14. A Computer-based 21st Century Prototype

    Directory of Open Access Journals (Sweden)

    Pannathon Sangarun

    2015-01-01

    Full Text Available Abstract This paper describes a prototype computer-based reading comprehension program. It begins with a short description, at a general level, of theoretical issues relating to the learning of comprehension skills in a foreign/second language learning. These issues cover such areas as personal meaning-making on the basis of individual differences and the need for individualized intervention to maximize the comprehension process. Modern technology facilitates this process and enables simultaneous support of large numbers of students. Specifically, from a learning perspective, the program focuses on students’ personal understandings while, from a reading perspective, the construction of meaning is based on an interactive model where both high-level (global, inferential structures are elicited/studied as well as low-level structures (e.g. vocabulary, grammar. These principles are strengthened with research findings from studies in awareness and language processing based on eye-movement analysis. As part of its reading comprehensions focus, the system also has a strong commitment to the development of critical thinking skills, recognized as one of the most important 21st Century skills. The program is then described in detail, including its ability to store students’ responses and to be administered through standard learning management systems. Finally, an outline of planned future developments and enhancements is presented.

  15. Report [of the] Expert Meeting on Intercultural Education, Section of Education for Peace and Human Rights (UNESCO Headquarters, Paris, March 20-22, 2006)

    Science.gov (United States)

    United Nations Educational, Scientific and Cultural Organization (UNESCO), 2006

    2006-01-01

    The Section of Education for Peace and Human Rights of the Division for the Promotion of Quality Education held an expert meeting on Intercultural Education from March 20-22, 2006 at UNESCO Headquarters, bringing together international experts from Australia, Bolivia, Egypt, Finland, Hungary, Korea, Lebanon, Mexico, Nigeria, South Africa and the…

  16. Twenty-First Century Creativity: An Investigation of How the Partnership for 21st Century Instructional Framework Reflects the Principles of Creativity

    Science.gov (United States)

    Guo, Jiajun; Woulfin, Sarah

    2016-01-01

    The purpose of this study is to consider how the 21st-century learning framework reflects principles of creativity. This article provides a qualitative analysis of the Partnership for 21st Century's (P21) policy documents, with a specific focus on how the principles of creativity, one of the 4Cs (creativity, critical thinking, collaboration, and…

  17. I mål med flipped learning

    DEFF Research Database (Denmark)

    Hachmann, Roland

    2016-01-01

    Kapitlet belyser, hvordan synlige læringsmål og stilladsering er to vigtige elementer i Flipped Learning. Kapitlet belyser en række metoder til at bringe eleven i centrum for sin egen læring og hvorledes underviseren kan differentiere sin undervisning for netop at støtte denne proces......Kapitlet belyser, hvordan synlige læringsmål og stilladsering er to vigtige elementer i Flipped Learning. Kapitlet belyser en række metoder til at bringe eleven i centrum for sin egen læring og hvorledes underviseren kan differentiere sin undervisning for netop at støtte denne proces...

  18. E-learning paradigmer og e-learning strategiudvikling

    DEFF Research Database (Denmark)

    Duus, Henrik Johannsen

    2003-01-01

    E-learning området er meget varieret hvad angår produkter, holdninger ogmeninger, og indeholder også en del 'støj' og mytedannelser, som afspejles i såvel denakademisk-videnskabelige som den journalistisk-offentlige debat om området. Dennevariation i såvel produkter som udtrykte meninger søges...... systematiseret og ordnet i fireidealtypiske paradigmer. Det vises, hvorledes disse fire paradigmer har hver sinebestemte karakteristika og udviklingsgrænser. Dette har afgørende strategisk betydningfor virksomheders og læreanstalters udvikling af e-learning, idet forkerte paradigmevalgvil hæmme udviklingen....

  19. Academic software development tools and techniques (Report on the 1st Workshop WASDeTT at ECOOP 2008)

    NARCIS (Netherlands)

    Wuyts, R.; Kienle, H.M.; Mens, K.; Brand, van den M.G.J.; Kuhn, A.; Eugster, P.

    2009-01-01

    The objective of the 1st International Workshop on Advanced Software Development Tools and Techniques (WASDeTT-1) was to provide interested researchers with a forum to share their tool building experiences and to explore how tools can be built more effectively and efficiently. The theme for this

  20. Language Learning Strategies in Second & Foreign Language Acquisition

    OpenAIRE

    TAKEUCHI, Osamu

    1991-01-01

    This article is an attempt to the work on language learning strategies(LLS) in second & foreign language acquisiton (SFLA) research, and to give suggestions for future language learning strategies research. In the first section, I will discuss briefly the background of language learning strategies reserch, and in the ensuing sections, I will review articles on: (i) the identification & classification of language learning strategies; (ii) the variables affecting the use of language learning st...

  1. Killing the Buddha: Towards a Heretical Philosophy of Learning

    Science.gov (United States)

    Johansson, Viktor

    2018-01-01

    This article explores how different philosophical models and pictures of learning can become dogmatic and disguise other conceptions of learning. With reference to a passage from St. Paul, I give a sense of the dogmatic teleology that underpins philosophical assumptions about learning. The Pauline assumption is exemplified through a variety of…

  2. Transforming Science Teaching Environment for the 21st Century Primary School Pupils

    Science.gov (United States)

    Sheikh Abdullah, Siti Hendon

    2016-01-01

    The transformation of technology in the 21st century has produced children who are technology savvy and exposed to the internet and social networking at a very young age. These children are already in our school system. Thus teachers too need to use technology and transform the learning environment to meet the requirements of these children. This…

  3. An Unfinished Symphony: 21st Century Teacher Education Using Knowledge Creating Heutagogies

    Science.gov (United States)

    Ashton, Jean; Newman, Linda

    2006-01-01

    Globalisation has changed the way most people live, work and study in the 21st century. Teachers and teacher educators, like other professionals, must embrace these changes to be effective in their jobs and one ongoing change is the use of Information Communication Technologies (ICTs) for lifelong learning. In this paper we describe how one group…

  4. 78 FR 51189 - Filing Dates for the Alabama Special Elections in the 1st Congressional District

    Science.gov (United States)

    2013-08-20

    ... 1st Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for... Congressional District vacated by Representative Jo Bonner. There are three possible special elections, but only... Election, the top two vote-getters will participate in a Special Runoff Election. General Election...

  5. Logical obstacles in learning planetary motion

    Science.gov (United States)

    Dileep, V.; Sathe, D. V.

    Daniel Schaffer wrote now-a-days scientists and particularly theoretical physicists are not held in unquestioned esteem in his editorial This became the starting point of my presentation which was dedicated to the memory of Abdus Salam 1 Had he survived to witness the IYP he would have become surprised on knowing that Frank Wilczek had maximum trouble in learning classical mechanics 2 These facts require us to restudy learning O level physics from the logical point of view - in order to attract promising young students to take up challenges of physics and astronomy of the 21 st century Newton s laws of motion are known for more than 300 years and so there should not be any problems in learning and teaching these laws now in the 21 st century But findings of educators reported in the last 30 years show that there are some serious and global problems I have shown that there are some logical obstacles which make adverse effect on the comprehension of circular motion and related topics 3 In this presentation relevant aspects are discussed References begin enumerate item D V Sathe August 2001 Chemical Education International http www iupac org publications cei vol2 0201x0026 html item Frank Wilczek October 2004 Physics Today p 11 item D V Sathe December 2001 COSPAR Info Bulletin 152 p 53 end enumerate

  6. Bathymetry 1M Grid of St. Croix (Buck Island), US Virgin Islands 2005, UTM 20 NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains an ESRI Grid with 1 meter cell size representing the bathymetry of the north shore of St. Croix (Buck Island), US Virgin Islands. NOAA's...

  7. Bathymetry 1M GRID of St. Croix (Buck Island), US Virgin Islands, 2004, UTM 20 WGS84

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains an ESRI Grid with 1 meter cell size representing the bathymetry of the north shore of Buck Island St. Croix, US Virgin Islands. NOAA's...

  8. NOAA ESRI Geotiff- 1m Bathymetry of St. Thomas, US Virgin Islands, 2004, UTM 20 WGS84

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains an ESRI Geotiff with 1 meter cell size representing the bathymetry of the south shore of St. Thomas, US Virgin Islands.NOAA's NOS/NCCOS/CCMA...

  9. AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists.

    Science.gov (United States)

    Moody, Terry W; Tashakkori, Nicole; Mantey, Samuel A; Moreno, Paola; Ramos-Alvarez, Irene; Leopoldo, Marcello; Jensen, Robert T

    2017-01-01

    While peptide antagonists for the gastrin-releasing peptide receptor (BB 2 R), neuromedin B receptor (BB 1 R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR. The BB agonist (BA)1 binds with high affinity to the BB 1 R, BB 2 R, and BRS-3. In this communication, small molecule BBR antagonists were evaluated using human lung cancer cells. AM-37 and ST-36 inhibited binding to human BB 1 R, BB 2 R, and BRS-3 with similar affinity ( K i = 1.4-10.8 µM). AM-13 and AM-14 were approximately an order of magnitude less potent than AM-37 and ST-36. The ability of BA1 to elevate cytosolic Ca 2+ in human lung cancer cells transfected with BB 1 R, BB 2 R, and BRS-3 was antagonized by AM-37 and ST-36. BA1 increased tyrosine phosphorylation of the EGFR and ERK in lung cancer cells, which was blocked by AM-37 and ST-36. AM-37 and ST-36 reduced the growth of lung cancer cells that have BBR. The results indicate that AM-37 and ST-36 function as small molecule BB receptor antagonists.

  10. Intraclonal Genome Stability of the Metallo-β-lactamase SPM-1-producing Pseudomonas aeruginosa ST277, an Endemic Clone Disseminated in Brazilian Hospitals.

    Science.gov (United States)

    Nascimento, Ana P B; Ortiz, Mauro F; Martins, Willames M B S; Morais, Guilherme L; Fehlberg, Lorena C C; Almeida, Luiz G P; Ciapina, Luciane P; Gales, Ana C; Vasconcelos, Ana T R

    2016-01-01

    Carbapenems represent the mainstay therapy for the treatment of serious P. aeruginosa infections. However, the emergence of carbapenem resistance has jeopardized the clinical use of this important class of compounds. The production of SPM-1 metallo-β-lactamase has been the most common mechanism of carbapenem resistance identified in P. aeruginosa isolated from Brazilian medical centers. Interestingly, a single SPM-1-producing P. aeruginosa clone belonging to the ST277 has been widely spread within the Brazilian territory. In the current study, we performed a next-generation sequencing of six SPM-1-producing P. aeruginosa ST277 isolates. The core genome contains 5899 coding genes relative to the reference strain P. aeruginos a PAO1. A total of 26 genomic islands were detected in these isolates. We identified remarkable elements inside these genomic islands, such as copies of the bla SPM-1 gene conferring resistance to carbapenems and a type I-C CRISPR-Cas system, which is involved in protection of the chromosome against foreign DNA. In addition, we identified single nucleotide polymorphisms causing amino acid changes in antimicrobial resistance and virulence-related genes. Together, these factors could contribute to the marked resistance and persistence of the SPM-1-producing P. aeruginosa ST277 clone. A comparison of the SPM-1-producing P. aeruginosa ST277 genomes showed that their core genome has a high level nucleotide similarity and synteny conservation. The variability observed was mainly due to acquisition of genomic islands carrying several antibiotic resistance genes.

  11. Pre-Service Physics Teachers’ Perception toward Hands-on Lab Activity and 21st Century Skills

    Science.gov (United States)

    Putri, D. H.; Risdianto, E.; Sutarno, S.

    2017-09-01

    This study aimed to describe the hands-on lab activities and 21st century skills of pre-service physics teachers at a university in Bengkulu. The respondents of this study were 113 students who have been finished and were following the laboratory course. The research instrument was questionnaire. The explored aspects of laboratory activities were motivation, the importance of laboratory activities, equipment, laboratory activities process, suitability of curriculum, assessment, laboratory design, and the 21st century skills training. The 21st century skills explored consist of learning and innovation skills, life and careers skills, and media, information and technology skills. The data obtained will be analyzed descriptively. Based on the results of data analysis was obtained that they have a good perception toward the aspect of motivation, the importance of hands-on lab activities, and laboratory activities process; and the perception was fair for other aspects. The lowest perception score was obtained in the aspects of the 21st century skills training. This result was in accordance with the 21st century skills of pre-service physics teachers which were still in moderate category. So it is necessary to develop a model of laboratory activities design that can training and enhancing the 21st century skills for pre-service physics teachers.

  12. 1st International Conference on Computational and Experimental Biomedical Sciences

    CERN Document Server

    Jorge, RM

    2015-01-01

    This book contains the full papers presented at ICCEBS 2013 – the 1st International Conference on Computational and Experimental Biomedical Sciences, which was organized in Azores, in October 2013. The included papers present and discuss new trends in those fields, using several methods and techniques, including active shape models, constitutive models, isogeometric elements, genetic algorithms, level sets, material models, neural networks, optimization, and the finite element method, in order to address more efficiently different and timely applications involving biofluids, computer simulation, computational biomechanics, image based diagnosis, image processing and analysis, image segmentation, image registration, scaffolds, simulation, and surgical planning. The main audience for this book consists of researchers, Ph.D students, and graduate students with multidisciplinary interests related to the areas of artificial intelligence, bioengineering, biology, biomechanics, computational fluid dynamics, comput...

  13. Challenges for Educational Technologists in the 21st Century

    Directory of Open Access Journals (Sweden)

    Robin Mayes

    2015-09-01

    Full Text Available In 1972, Edsger Dijkstra claimed that computers had only introduced the new problem of learning to use them effectively. This is especially true in 2015 with regard to powerful new educational technologies. This article describes the challenges that 21st century educational technologists are, and will be, addressing as they undertake the effective integration of new technologies into K-12 educational systems and learning environments. The expanding Internet, ever more powerful mobile devices, and other innovations make the task of designing effective formal and informal learning challenging, especially in light of the high rate of change in these new technologies. While these technologies introduce many benefits, they are also causing serious threats to system security and personal privacy. Furthermore, as these technologies continue to evolve, ethical issues such as equal access to resources become imperative. Educational technologists must expand their forward-thinking leadership and planning competencies so as to ensure effective use of new technologies.

  14. NOAA TIFF Image - 1m Multibeam Bathymetry, US Virgin Islands - St. John Shelf - Project NF-10-03 - (2010), UTM 20N NAD83 (NCEI Accession 0131854)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a GeoTIFF with 1x1 meter cell size representing the bathymetry of St. John Shelf, a selected portion of seafloor south of St. John, USVI,...

  15. Competences, Learning Theories and MOOCs: Recent Developments in Lifelong Learning

    Science.gov (United States)

    Steffens, Karl

    2015-01-01

    Our societies have come to be known as knowledge societies in which lifelong learning is becoming increasingly important. In this context, competences have become a much discussed topic. Many documents were published by international organisations (UNESCO, World Bank, European Commission) which enumerated 21st century key competences. The field of…

  16. Teaching-learning: stereoscopic 3D versus Traditional methods in Mexico City.

    Science.gov (United States)

    Mendoza Oropeza, Laura; Ortiz Sánchez, Ricardo; Ojeda Villagómez, Raúl

    2015-01-01

    In the UNAM Faculty of Odontology, we use a stereoscopic 3D teaching method that has grown more common in the last year, which makes it important to know whether students can learn better with this strategy. The objective of the study is to know, if the 4th year students of the bachelor's degree in dentistry learn more effectively with the use of stereoscopic 3D than the traditional method in Orthodontics. first, we selected the course topics, to be used for both methods; the traditional method using projection of slides and for the stereoscopic third dimension, with the use of videos in digital stereo projection (seen through "passive" polarized 3D glasses). The main topic was supernumerary teeth, including and diverted from their guide eruption. Afterwards we performed an exam on students, containing 24 items, validated by expert judgment in Orthodontics teaching. The results of the data were compared between the two educational methods for determined effectiveness using the model before and after measurement with the statistical package SPSS 20 version. The results presented for the 9 groups of undergraduates in dentistry, were collected with a total of 218 students for 3D and traditional methods, we found in a traditional method a mean 4.91, SD 1.4752 in the pretest and X=6.96, SD 1.26622, St Error 0.12318 for the posttest. The 3D method had a mean 5.21, SD 1.996779 St Error 0.193036 for the pretest X= 7.82, SD =0.963963, St Error 0.09319 posttest; the analysis of Variance between groups F= 5.60 Prob > 0.0000 and Bartlett's test for equal variances 21.0640 Prob > chi2 = 0.007. These results show that the student's learning in 3D means a significant improvement as compared to the traditional teaching method and having a strong association between the two methods. The findings suggest that the stereoscopic 3D method lead to improved student learning compared to traditional teaching.

  17. Promoting Best Practices in Teaching and Learning in Nigerian Universities through Effective E-Learning: Prospects and Challenges

    Science.gov (United States)

    Obuekwe, Grace Ifeoma; Eze, Rose-Ann Ifeoma

    2017-01-01

    The importance of e-learning in our educational system as well as the nation's development cannot be over-emphasized. The use of e-learning in impartation and acquisition of knowledge by lecturers and students is becoming a vital tool in meeting the demands of education in the 21st century. The paper is aimed at exploring the prospects and…

  18. Mount St. Helens, 1980 to now—what’s going on?

    Science.gov (United States)

    Dzurisin, Daniel; Driedger, Carolyn L.; Faust, Lisa M.

    2013-01-01

    Mount St. Helens seized the world’s attention in 1980 when the largest historical landslide on Earth and a powerful explosive eruption reshaped the volcano, created its distinctive crater, and dramatically modified the surrounding landscape. An enormous lava dome grew episodically in the crater until 1986, when the volcano became relatively quiet. A new glacier grew in the crater, wrapping around and partly burying the lava dome. From 1987 to 2003, sporadic earthquake swarms and small steam explosions indicated that magma (molten rock) was being replenished deep underground. In 2004, steam-and-ash explosions heralded the start of another eruption. A quieter phase of continuous lava extrusion followed and lasted until 2008, building a new dome and doubling the volume of lava on the crater floor. Scientists with the U.S. Geological Survey and University of Washington’s Pacific Northwest Seismograph Network maintain constant watch for signs of renewed activity at Mount St. Helens and other Cascade volcanoes. Now is an ideal time for both actual and virtual visitors to Mount St. Helens to learn more about dramatic changes taking place on and beneath this active volcano.

  19. Parametric decadal climate forecast recalibration (DeFoReSt 1.0

    Directory of Open Access Journals (Sweden)

    A. Pasternack

    2018-01-01

    Full Text Available Near-term climate predictions such as decadal climate forecasts are increasingly being used to guide adaptation measures. For near-term probabilistic predictions to be useful, systematic errors of the forecasting systems have to be corrected. While methods for the calibration of probabilistic forecasts are readily available, these have to be adapted to the specifics of decadal climate forecasts including the long time horizon of decadal climate forecasts, lead-time-dependent systematic errors (drift and the errors in the representation of long-term changes and variability. These features are compounded by small ensemble sizes to describe forecast uncertainty and a relatively short period for which typically pairs of reforecasts and observations are available to estimate calibration parameters. We introduce the Decadal Climate Forecast Recalibration Strategy (DeFoReSt, a parametric approach to recalibrate decadal ensemble forecasts that takes the above specifics into account. DeFoReSt optimizes forecast quality as measured by the continuous ranked probability score (CRPS. Using a toy model to generate synthetic forecast observation pairs, we demonstrate the positive effect on forecast quality in situations with pronounced and limited predictability. Finally, we apply DeFoReSt to decadal surface temperature forecasts from the MiKlip prototype system and find consistent, and sometimes considerable, improvements in forecast quality compared with a simple calibration of the lead-time-dependent systematic errors.

  20. Parametric decadal climate forecast recalibration (DeFoReSt 1.0)

    Science.gov (United States)

    Pasternack, Alexander; Bhend, Jonas; Liniger, Mark A.; Rust, Henning W.; Müller, Wolfgang A.; Ulbrich, Uwe

    2018-01-01

    Near-term climate predictions such as decadal climate forecasts are increasingly being used to guide adaptation measures. For near-term probabilistic predictions to be useful, systematic errors of the forecasting systems have to be corrected. While methods for the calibration of probabilistic forecasts are readily available, these have to be adapted to the specifics of decadal climate forecasts including the long time horizon of decadal climate forecasts, lead-time-dependent systematic errors (drift) and the errors in the representation of long-term changes and variability. These features are compounded by small ensemble sizes to describe forecast uncertainty and a relatively short period for which typically pairs of reforecasts and observations are available to estimate calibration parameters. We introduce the Decadal Climate Forecast Recalibration Strategy (DeFoReSt), a parametric approach to recalibrate decadal ensemble forecasts that takes the above specifics into account. DeFoReSt optimizes forecast quality as measured by the continuous ranked probability score (CRPS). Using a toy model to generate synthetic forecast observation pairs, we demonstrate the positive effect on forecast quality in situations with pronounced and limited predictability. Finally, we apply DeFoReSt to decadal surface temperature forecasts from the MiKlip prototype system and find consistent, and sometimes considerable, improvements in forecast quality compared with a simple calibration of the lead-time-dependent systematic errors.

  1. Methicillin-Resistant Staphylococcus aureus ST398 from Human Patients, Upper Austria

    Science.gov (United States)

    Metz-Gercek, Sigrid; Mittermayer, Helmut

    2009-01-01

    Methicillin-resistant Staphylococcus aureus (MRSA) clonal type ST398 is usually associated with animals. We examined 1,098 confirmed MRSA samples from human patients and found that 21 were MRSA ST398. Most (16) patients were farmers. Increasing prevalence from 1.3% (2006) to 2.5% (2008) shows emergence of MRSA ST398 in humans in Austria. PMID:19402964

  2. 75 FR 12544 - Filing Dates for the Hawaii Special Election In the 1st Congressional District

    Science.gov (United States)

    2010-03-16

    ... 1st Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for special election. SUMMARY: Hawaii has scheduled a Special General Election on May 22, 2010, to fill the U.... Committees required to file reports in connection with the Special General Election on May 22, 2010, shall...

  3. AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for United States Coast Guard Headquarters

    Energy Technology Data Exchange (ETDEWEB)

    Schey, Stephen [Idaho National Lab. (INL), Idaho Falls, ID (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-05-01

    Federal agencies are mandated to purchase alternative fuel vehicles, increase consumption of alternative fuels, and reduce petroleum consumption. Available plug-in electric vehicles (PEVs) provide an attractive option in the selection of alternative fuel vehicles. PEVs, which consist of both battery electric vehicles (BEVs) and plug-in hybrid electric vehicles (PHEVs), have significant advantages over internal combustion engine (ICE) vehicles in terms of energy efficiency, reduced petroleum consumption, and reduced production of greenhouse gas (GHG) emissions, and they provide performance benefits with quieter, smoother operation. This study intended to evaluate the extent to which the United States Coast Guard Headquarters (USCG HQ) could convert part or all of their fleet of vehicles from petroleum-fueled vehicles to PEVs.

  4. Investigating collaborative learning success with physiological coupling indices based on electrodermal activity

    NARCIS (Netherlands)

    Pijeira-díaz, Hector; Drachsler, Hendrik; Järvelä, Sanna; Kirschner, Paul A.

    2017-01-01

    Collaborative learning is considered a critical 21st century skill. Much is known about its contribution to learning, but still investigating a process of collaboration remains a challenge. This paper approaches the investigation on collaborative learning from a psychophysiological perspective. An

  5. Tracking legacy radionuclides in St. Louis, Missouri, via unsupported "2"1"0Pb

    International Nuclear Information System (INIS)

    Kaltofen, Marco P.J.; Alvarez, Robert; Hixson, Lucas

    2016-01-01

    Analysis of 287 soil, sediment and house dust samples collected in a 200 km"2-zone in northern St. Louis County, Missouri, establish that offsite migration of radiological contaminants from Manhattan Project-era uranium processing wastes has occurred in this populated area. Specifically, 48% of samples (111 of a subset of 229 soils and sediments tested) had "2"1"0Pb concentrations above the risk-based soil cleanup limits for residential farming established by the US Department of Energy at the Fernald, OH, uranium plant, which handled and stored the same concentrated Manhattan Project-era wastes; the geographical distribution of the exceedances are consistent with water and radon gas releases from a landfill and related sites used to store and dispose of legacy uranium wastes; and offsite soil and house dust samples proximal to the landfill showed distinctive secular disequilibrium among uranium and its progeny indicative of uranium ore processing wastes. The secular disequilibrium of uranium progeny in the environment provides an important method for distinguishing natural uranium from industrial uranium wastes. In this study, the detection of unsupported "2"1"0Pb beyond expected atmospheric deposition rates is examined as a possible indicator of excessive radon emissions from buried uranium and radium-containing wastes. - Highlights: • We sampled and analyzed 287 urban soils and sediments for uranium processing wastes. • Radium and unsupported "2"1"0Pb were the primary tracers for wastes. • The goal was to track Manhattan Project wastes around St. Louis, MO. • Activity levels in the environment peaked around land disposal sites. • Unsupported "2"1"0Pb and isotopic uranium & thorium were also found in house dusts.

  6. Beyond Traditional Literacy: Learning and Transformative Practices Using ICT

    Science.gov (United States)

    Keane, Therese; Keane, William F.; Blicblau, Aaron S.

    2016-01-01

    Educators, government bodies and employers have acknowledged the need for modern learners to acquire 21st century skills using information and communication technologies, to personalise student learning. Students need broader skills than the 3Rs (reading, writing and arithmetic) to operate in the 21st century. These broader skills known as the 4Cs…

  7. Theoretical Perspectives of How Digital Natives Learn

    Science.gov (United States)

    Kivunja, Charles

    2014-01-01

    Marck Prensky, an authority on teaching and learning especially with the aid of Information and Communication Technologies, has referred to 21st century children born after 1980 as "Digital Natives". This paper reviews literature of leaders in the field to shed some light on theoretical perspectives of how Digital Natives learn and how…

  8. PROMOTING MEANINGFUL LEARNING THROUGH CREATE-SHARE-COLLABORATE

    OpenAIRE

    Sailin, Siti Nazuar; Mahmor, Noor Aida

    2017-01-01

    Students in this 21st century are required to acquire these 4C skills: Critical thinking, Communication, Collaboration and Creativity. These skills can be integrated in the teaching and learning through innovative teaching that promotes active and meaningful learning. One way of integrating these skills is through collaborative knowledge creation and sharing. This paper providesan example of meaningful teaching and learning activities designed within the Create-Share-Collaborate instructional...

  9. AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists

    Directory of Open Access Journals (Sweden)

    Terry W. Moody

    2017-07-01

    Full Text Available While peptide antagonists for the gastrin-releasing peptide receptor (BB2R, neuromedin B receptor (BB1R, and bombesin (BB receptor subtype-3 (BRS-3 exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR. The BB agonist (BA1 binds with high affinity to the BB1R, BB2R, and BRS-3. In this communication, small molecule BBR antagonists were evaluated using human lung cancer cells. AM-37 and ST-36 inhibited binding to human BB1R, BB2R, and BRS-3 with similar affinity (Ki = 1.4–10.8 µM. AM-13 and AM-14 were approximately an order of magnitude less potent than AM-37 and ST-36. The ability of BA1 to elevate cytosolic Ca2+ in human lung cancer cells transfected with BB1R, BB2R, and BRS-3 was antagonized by AM-37 and ST-36. BA1 increased tyrosine phosphorylation of the EGFR and ERK in lung cancer cells, which was blocked by AM-37 and ST-36. AM-37 and ST-36 reduced the growth of lung cancer cells that have BBR. The results indicate that AM-37 and ST-36 function as small molecule BB receptor antagonists.

  10. AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists

    Science.gov (United States)

    Moody, Terry W.; Tashakkori, Nicole; Mantey, Samuel A.; Moreno, Paola; Ramos-Alvarez, Irene; Leopoldo, Marcello; Jensen, Robert T.

    2017-01-01

    While peptide antagonists for the gastrin-releasing peptide receptor (BB2R), neuromedin B receptor (BB1R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR. The BB agonist (BA)1 binds with high affinity to the BB1R, BB2R, and BRS-3. In this communication, small molecule BBR antagonists were evaluated using human lung cancer cells. AM-37 and ST-36 inhibited binding to human BB1R, BB2R, and BRS-3 with similar affinity (Ki = 1.4–10.8 µM). AM-13 and AM-14 were approximately an order of magnitude less potent than AM-37 and ST-36. The ability of BA1 to elevate cytosolic Ca2+ in human lung cancer cells transfected with BB1R, BB2R, and BRS-3 was antagonized by AM-37 and ST-36. BA1 increased tyrosine phosphorylation of the EGFR and ERK in lung cancer cells, which was blocked by AM-37 and ST-36. AM-37 and ST-36 reduced the growth of lung cancer cells that have BBR. The results indicate that AM-37 and ST-36 function as small molecule BB receptor antagonists. PMID:28785244

  11. Uncertainty Requirement Analysis for the Orbit, Attitude, and Burn Performance of the 1st Lunar Orbit Insertion Maneuver

    Directory of Open Access Journals (Sweden)

    Young-Joo Song

    2016-12-01

    Full Text Available In this study, the uncertainty requirements for orbit, attitude, and burn performance were estimated and analyzed for the execution of the 1st lunar orbit insertion (LOI maneuver of the Korea Pathfinder Lunar Orbiter (KPLO mission. During the early design phase of the system, associate analysis is an essential design factor as the 1st LOI maneuver is the largest burn that utilizes the onboard propulsion system; the success of the lunar capture is directly affected by the performance achieved. For the analysis, the spacecraft is assumed to have already approached the periselene with a hyperbolic arrival trajectory around the moon. In addition, diverse arrival conditions and mission constraints were considered, such as varying periselene approach velocity, altitude, and orbital period of the capture orbit after execution of the 1st LOI maneuver. The current analysis assumed an impulsive LOI maneuver, and two-body equations of motion were adapted to simplify the problem for a preliminary analysis. Monte Carlo simulations were performed for the statistical analysis to analyze diverse uncertainties that might arise at the moment when the maneuver is executed. As a result, three major requirements were analyzed and estimated for the early design phase. First, the minimum requirements were estimated for the burn performance to be captured around the moon. Second, the requirements for orbit, attitude, and maneuver burn performances were simultaneously estimated and analyzed to maintain the 1st elliptical orbit achieved around the moon within the specified orbital period. Finally, the dispersion requirements on the B-plane aiming at target points to meet the target insertion goal were analyzed and can be utilized as reference target guidelines for a mid-course correction (MCC maneuver during the transfer. More detailed system requirements for the KPLO mission, particularly for the spacecraft bus itself and for the flight dynamics subsystem at the ground

  12. 76 FR 51366 - Filing Dates for the Oregon Special Election in the 1st Congressional District

    Science.gov (United States)

    2011-08-18

    ... 1st Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for... Special Primary and Special General Election on January 31, 2012, shall file a 12-day Pre-Primary Report... Primary and Special General Elections shall file a 12-day Pre-Primary Report on October 27, 2011; a...

  13. Minor Electrocardiographic ST-T Change and Risk of Stroke in the General Japanese Population.

    Science.gov (United States)

    Ishikawa, Joji; Hirose, Hideo; Schwartz, Joseph E; Ishikawa, Shizukiyo

    2018-06-25

    Minor ST-T changes are frequently observed on the electrocardiogram (ECG), but the risk of stroke associated with such changes is unclear.Methods and Results:In 10,642 subjects from the Japanese general population, we evaluated minor and major ST-T changes (major ST depression ≥0.1 mV) on ECGs obtained at annual health examinations. At baseline, minor ST-T changes were found in 10.7% of the subjects and 0.5% had major ST-T changes. Minor ST-T changes were associated with older age, female gender, higher systolic blood pressure, presence of hyperlipidemia, and use of antihypertensive medication. There were 375 stroke events during the follow-up period (128.7±28.1 months). In all subjects, minor ST-T changes (HR, 2.10; 95% CI: 1.57-2.81) and major ST-T changes (HR, 8.64; 95% CI: 4.44-16.82) were associated with an increased risk of stroke, but the stroke risk associated with minor ST-T changes had borderline significance after adjustment for conventional risk factors (P=0.055). In subgroup analysis, the risk of stroke was significantly associated with minor ST-T changes in subjects who had hyperlipidemia (HR, 1.75; 95% CI: 1.15-2.67) compared to those without hyperlipidemia (HR, 1.01; 95% CI: 0.64-1.59; P for interaction=0.016), even after adjustment for ECG-diagnosed left ventricular hypertrophy. Minor ST-T changes were particularly associated with a higher risk of stroke in subjects with hyperlipidemia and this association was independent of electrocardiographic left ventricular hypertrophy.

  14. Intraclonal Genome Stability of the Metallo-β-lactamase SPM-1-producing Pseudomonas aeruginosa ST277, an Endemic Clone Disseminated in Brazilian Hospitals

    Directory of Open Access Journals (Sweden)

    Ana Paula Barbosa Nascimento

    2016-12-01

    Full Text Available Carbapenems represent the mainstay therapy for the treatment of serious P. aeruginosa infections. However, the emergence of carbapenem resistance has jeopardized the clinical use of this important class of compounds. The production of SPM-1 metallo-β-lactamase has been the most common mechanism of carbapenem resistance identified in P. aeruginosa isolated from Brazilian medical centres. Interestingly, a single SPM-1-producing P. aeruginosa clone belonging to the ST277 has been widely spread within the Brazilian territory. In the current study, we performed a next-generation sequencing of six SPM-1-producing P. aeruginosa ST277 isolates. The core genome contains 5 899 coding genes relative to the reference strain P. aeruginosa PAO1. A total of 26 genomic islands were detected in these isolates. We identified remarkable elements inside these genomic islands, such as copies of the blaSPM-1 gene conferring resistance to carbapenems and a type I-C CRISPR-Cas system, which is involved in protection of the chromosome against foreign DNA. In addition, we identified single nucleotide polymorphisms causing amino acid changes in antimicrobial resistance and virulence-related genes. Together, these factors could contribute to the marked resistance and persistence of the SPM-1-producing P. aeruginosa ST277 clone. A comparison of the SPM-1-producing P. aeruginosa ST277 genomes showed that their core genome has a high level nucleotide similarity and synteny conservation. The variability observed was mainly due to acquisition of genomic islands carrying several antibiotic resistance genes.

  15. Implicit learning: What does it all mean - Response

    OpenAIRE

    Shanks, D. R.; StJohn, M. F.

    1996-01-01

    In the original target article (Shanks & St. John 1994), one of our principal conclusions was that there is almost no evidence that learning can occur outside awareness. The continuing commentaries raise some interesting questions, especially about the definition of learning, but do not lead us to abandon our conclusion.

  16. Frequency of hepatitis B in asymptomatic patients of district Headquarter hospital Kotli, Azad Kashmir

    International Nuclear Information System (INIS)

    Sarwar, J.; Ahmad, W.; Saleem, M.; Jamshed, F.; Gul, N.; Idrees, M.

    2010-01-01

    Background: Hepatitis B is prevalent throughout the world including Pakistan. A large proportion of patients suffering from Hepatitis B may be asymptomatic and can transmit the disease to healthy population. Objectives of this study were to estimate the frequency of Hepatitis B in asymptomatic adult population coming to District Headquarter Hospital Kotli, Azad Kashmir and to determine the risk factors associated with its transmission. Methods: This was a cross-sectional study extending from January to December 2008. Subjects were randomly selected from those who attended the medial OPD of DHQ Hospital Kotli, Azad Kashmir for non-Hepatitis related problems. Both males and females between the ages of 15-80 years were included in the study. Blood samples taken from selected subjects were analysed for Hepatitis B surface antigen (HBsAg) by Immuno chromatographic kit methods (ICT). Hepatitis B positive samples were further confirmed by third generation ELIZA. The patients thus confirmed were interrogated for different risk factors associated with transmission of Hepatitis B. Results: A total of 9,564 patients were analysed. Out of them 4230 (44.22%) were males and 5334 (55.77%) were females. Overall 141 (1.47%) patients were positive for HBSAg, 71 (1.68%) males and 70 (1.31%) females. Patients between 21-30 years of age were most commonly effected (35.46%, n=50). Blood transfusion was the most common risk factor (24.82%, n=35) associated with Hepatitis B transmission followed by dental procedures (14.18%, n=20). Conclusion: Frequency of Hepatitis B in asymptomatic people in this study was quite high. Blood transfusions and dental procedures were the most common risk factors associated with the transmission of Hepatitis B. (author)

  17. Learning Content Management Systems

    Directory of Open Access Journals (Sweden)

    Tache JURUBESCU

    2008-01-01

    Full Text Available The paper explains the evolution of e-Learning and related concepts and tools and its connection with other concepts such as Knowledge Management, Human Resources Management, Enterprise Resource Planning, and Information Technology. The paper also distinguished Learning Content Management Systems from Learning Management Systems and Content Management Systems used for general web-based content. The newest Learning Content Management System, very expensive and yet very little implemented is one of the best tools that helps us to cope with the realities of the 21st Century in what learning concerns. The debates over how beneficial one or another system is for an organization, can be driven by costs involved, efficiency envisaged, and availability of the product on the market.

  18. St. James marine terminal facility description

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    The US Department of Energy (DOE) currently owns and operates a marine terminal on the west bank of the Mississippi River at St. James, Louisiana. The St. James facility was constructed by the Department to provide marine services associated with the fill and drawdown of the Strategic Petroleum Reserve (SPR) crude oil storage facilities located at Bayou Choctaw and Weeks Island, Louisiana. Although strategic to the mission of the SPR in the event of a national emergency, the St. James terminal is situated such that it has a high potential to also serve the commercial industry`s needs for crude oil terminalling and storage. The St. James terminal is located approximately 45 miles west of New Orleans and 30 miles southeast of Baton Rouge, and approximately 160 miles upstream from the mouth of the Mississippi River. Construction of the St. James terminal was initiated in 1978 and was completed in 1980. Since then, the terminal has received and transferred over 125 million barrels of crude oil to the SPR sites for storage. For crude oil distribution, the St. James terminal was connected to the neighboring LOCAP terminal by a 0.1 mile 36-inch pipeline in 1981 and to the Capline terminal by a 0.5 mile 30-inch pipeline in 1988. The terminal also has a 30-inch pipeline connection to the Koch oil terminal which was used for initial fill purposes; however, this pipeline has been disconnected and is currently inactive. A complete description of the St. James terminal facilities, operational capabilities, operational certifications, and future Government requirements are presented in Sections 2, 3, 4, and 5 respectively.

  19. The central role of learning in videogaming

    OpenAIRE

    Fabricatore, Carlo; López, Ximena; Dill, Karen E.

    2009-01-01

    In the 21st century, being a parent means having to deal with buying, monitoring, and negotiating about video games. A common question parents have is whether children can learn anything positive or of educational value by playing video games? The answer is “Yes!” Children can learn valuable skills by playing video games.

  20. 1st Cavalry Division’s Effectiveness In Conducting Airmobile Operations During Operation Pegasus

    Science.gov (United States)

    2016-05-26

    HQ Provisional Corps Vietnam, 1968), 30. 4 Story created by Author, derived from events found in 1st Cavalry Division (Airmobile), Combat Operations...not available. However, a limitation of this was that aerial fire support had limited capability in restrictive weather conditions, such as low clouds ...Cavalry Division (Airmobile) Tactical SOP, Annex O. 88 Robert, Cushman to John Tolson, January 28, 1968, MSG, HQ III MAF 25 1428z JAN 68 Subject

  1. Situation Desperate: U.S. Army Engineer Disaster Relief Operations, Origins to 1950

    Science.gov (United States)

    2011-01-01

    the Sabine River sub- office, for example, relayed the following sad report to headquarters: “I regret to report the loss of all property in my...doctor with typhoid vaccine ; the cows and horses and dogs of every description wandering up and down the levees; the fur- niture, every kind of...215 Sabine River, 59 Sacramento Engineer District, 237, 238 Sacramento River, 186, 237 St. Francis River, 85, 87 St. Joe River, 217 St. Louis Engineer

  2. PREFACE: 1st European Conference on Gas Micro Flows (GasMems 2012)

    Science.gov (United States)

    Frijns, Arjan; Valougeorgis, Dimitris; Colin, Stéphane; Baldas, Lucien

    2012-05-01

    The aim of the 1st European Conference on Gas Micro Flows is to advance research in Europe and worldwide in the field of gas micro flows as well as to improve global fundamental knowledge and to enable technological applications. Gas flows in microsystems are of great importance and touch almost every industrial field (e.g. fluidic microactuators for active control of aerodynamic flows, vacuum generators for extracting biological samples, mass flow and temperature micro-sensors, pressure gauges, micro heat-exchangers for the cooling of electronic components or for chemical applications, and micro gas analyzers or separators). The main characteristic of gas microflows is their rarefaction, which for device design often requires modelling and simulation both by continuous and molecular approaches. In such flows various non-equilibrium transport phenomena appear, while the role played by the interaction between the gas and the solid device surfaces becomes essential. The proposed models of boundary conditions often need an empirical adjustment strongly dependent on the micro manufacturing technique. The 1st European Conference on Gas Micro Flows is organized under the umbrella of the recently established GASMEMS network (www.gasmems.eu/) consisting of 13 participants and six associate members. The main objectives of the network are to structure research and train researchers in the fields of micro gas dynamics, measurement techniques for gaseous flows in micro experimental setups, microstructure design and micro manufacturing with applications in lab and industry. The conference takes place on June 6-8 2012, at the Skiathos Palace Hotel, on the beautiful island of Skiathos, Greece. The conference has received funding from the European Community's Seventh Framework Programme FP7/2007-2013 under grant agreement ITN GASMEMS no. 215504. It owes its success to many people. We would like to acknowledge the support of all members of the Scientific Committee and of all

  3. Student-Centered Learning: Functional Requirements for Integrated Systems to Optimize Learning

    Science.gov (United States)

    Glowa, Liz; Goodell, Jim

    2016-01-01

    The realities of the 21st-century learner require that schools and educators fundamentally change their practice. "Educators must produce college- and career-ready graduates that reflect the future these students will face. And, they must facilitate learning through means that align with the defining attributes of this generation of…

  4. EkSTEMiT Learning Module and Inculcation of Inventive Thinking

    Directory of Open Access Journals (Sweden)

    Norhaslinda Abdul Samad

    2017-10-01

    Full Text Available The young generation of today must be prepared with the knowledge and skills necessary to be able to compete globally thus boosting economic growth and prosperity. Therefore, students should not only be equipped with knowledge but they are in need of the “21st century skills”, which is the top priority and one of the main education agenda goals today. As one of the domains in the 21st century skills, inventive thinking includes elements of flexibility, self-regulation, curiosity, creativity, risk taking, higher order thinking and reasoning. In order to inculcate inventive thinking for students, the EkSTEMiT Learning Module was developed for the topic Electrochemistry; one of the most difficult topics to learn among students. EkSTEMiT Learning Module was developed based on the STEM (Science, Technology, Engineering and Mathematics integrated model. Thus, this paper will discuss the conceptual framework underlying the development of EkSTEMiT Learning Module with descriptions of learning activities designed for Electrochemistry.

  5. Service-Learning Might Be the Key: Learning from the Challenges and Implementation Strategies in EFL Teacher Education in Oman

    Science.gov (United States)

    Al Barwani, Thuwayba; Al-Mekhlafi, Abdo; Nagaratnam, Ramani Perur

    2013-01-01

    Service-learning, a major reform in higher education, is considered essential for developing citizenship for the 21st century. This paper reports a study aimed at investigating the problems and challenges faced when implementing service-learning in pre-service education of teachers of English as a Foreign Language (EFL) and carried out in the…

  6. Presentations and recorded keynotes of the First European Workshop on Latent Semantic Analysis in Technology Enhanced Learning

    NARCIS (Netherlands)

    Several

    2007-01-01

    Presentations and recorded keynotes at the 1st European Workshop on Latent Semantic Analysis in Technology-Enhanced Learning, March, 29-30, 2007. Heerlen, The Netherlands: The Open University of the Netherlands. Please see the conference website for more information:

  7. Applying perceptual and adaptive learning techniques for teaching introductory histopathology

    Directory of Open Access Journals (Sweden)

    Sally Krasne

    2013-01-01

    Full Text Available Background: Medical students are expected to master the ability to interpret histopathologic images, a difficult and time-consuming process. A major problem is the issue of transferring information learned from one example of a particular pathology to a new example. Recent advances in cognitive science have identified new approaches to address this problem. Methods: We adapted a new approach for enhancing pattern recognition of basic pathologic processes in skin histopathology images that utilizes perceptual learning techniques, allowing learners to see relevant structure in novel cases along with adaptive learning algorithms that space and sequence different categories (e.g. diagnoses that appear during a learning session based on each learner′s accuracy and response time (RT. We developed a perceptual and adaptive learning module (PALM that utilized 261 unique images of cell injury, inflammation, neoplasia, or normal histology at low and high magnification. Accuracy and RT were tracked and integrated into a "Score" that reflected students rapid recognition of the pathologies and pre- and post-tests were given to assess the effectiveness. Results: Accuracy, RT and Scores significantly improved from the pre- to post-test with Scores showing much greater improvement than accuracy alone. Delayed post-tests with previously unseen cases, given after 6-7 weeks, showed a decline in accuracy relative to the post-test for 1 st -year students, but not significantly so for 2 nd -year students. However, the delayed post-test scores maintained a significant and large improvement relative to those of the pre-test for both 1 st and 2 nd year students suggesting good retention of pattern recognition. Student evaluations were very favorable. Conclusion: A web-based learning module based on the principles of cognitive science showed an evidence for improved recognition of histopathology patterns by medical students.

  8. 78 FR 19632 - Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St...

    Science.gov (United States)

    2013-04-02

    ...-AA08 Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St... proposes to establish a special local regulation on the waters of Charlotte Amalie Harbor in St Thomas, USVI during the St. Thomas Carnival Watersport Activities, a high speed boat race. The event is...

  9. It takes biking to learn: Physical activity improves learning a second language.

    Science.gov (United States)

    Liu, Fengqin; Sulpizio, Simone; Kornpetpanee, Suchada; Job, Remo

    2017-01-01

    Recent studies have shown that concurrent physical activity enhances learning a completely unfamiliar L2 vocabulary as compared to learning it in a static condition. In this paper we report a study whose aim is twofold: to test for possible positive effects of physical activity when L2 learning has already reached some level of proficiency, and to test whether the assumed better performance when engaged in physical activity is limited to the linguistic level probed at training (i.e. L2 vocabulary tested by means of a Word-Picture Verification task), or whether it extends also to the sentence level (which was tested by means of a Sentence Semantic Judgment Task). The results show that Chinese speakers with basic knowledge of English benefited from physical activity while learning a set of new words. Furthermore, their better performance emerged also at the sentential level, as shown by their performance in a Semantic Judgment task. Finally, an interesting temporal asymmetry between the lexical and the sentential level emerges, with the difference between the experimental and control group emerging from the 1st testing session at the lexical level but after several weeks at the sentential level.

  10. A multiplex, internally controlled real-time PCR assay for detection of toxigenic Clostridium difficile and identification of hypervirulent strain 027/ST-1

    DEFF Research Database (Denmark)

    Hoegh, A M; Nielsen, J B; Lester, A

    2012-01-01

    The purpose of this study was to validate a multiplex real-time PCR assay capable of detecting toxigenic Clostridium difficile and simultaneously identifying C. difficile ribotype 027/ST-1 by targeting the toxin genes tcdA, tcdB and cdtA in one reaction and in a separate reaction identifying the Δ...... to confirm the correct identification of the Δ117 deletion in tcdC and C. difficile ribotype 027/ST-1, respectively. The PCR assay displayed a sensitivity, specificity, PPV and NPV of 99.0%, 97.4%, 87.4% and 99.8%, respectively, compared to toxigenic culture on 665 samples evaluable both by PCR and culture....... Sequencing of tcdC, ribotyping and MLST of cultured isolates validated the genotyping assay and confirmed the ability of the assay to correctly identify C. difficile ribotype 027/ST-1 in our current epidemiological setting. We describe the use of a combination of two separate PCR assays for sensitive...

  11. Texts of the Agency's Agreements with the Republic of Austria. A further supplemental agreement to the Headquarters Agreement. Supplemental Agreement pursuant to Section 4(b) of the Agreement between the Republic of Austria and the International Atomic Energy Agency regarding the Headquarters of the International Atomic Energy Agency

    International Nuclear Information System (INIS)

    1996-01-01

    The text of the exchange of Notes, dated 6 July 1995 and 29 September 1995 respectively, between the IAEA and the Ministry of Foreign Affairs of Austria regarding Section 4(b) of the Headquarters Agreement which allows the IAEA 'to establish and operate such additional radio and other telecommunications facilities as may be specified by supplemental agreement ....' is reproduced in this document for the information of all Members of the Agency

  12. History and Future of Technology-Enhanced Learning

    NARCIS (Netherlands)

    Westera, Wim

    2009-01-01

    Westera, W. (2009). History and Future of Technology-Enhanced Learning. Keynote Presentation at the First International Conference on Software, Services & Semantic Technologies (3ST). October, 28, 2009, Sofia, Bulgaria.

  13. Right bundle branch block and anterior wall ST elevation myocardial infarction.

    Science.gov (United States)

    Trofin, Monica; Israel, Carsten W; Barold, S Serge

    2017-09-01

    We report the case of an acute anterior wall ST elevation myocardial infarction with new left anterior fascicular block and pre-existing right bundle branch block. Due to a wide right bundle branch block, no ST segment elevation was visible in lead V1. The left anterior fascicular block was caused by proximal occlusion of the left artery descending and disappeared after acute revascularization. However, also the R' of the right bundle branch block became significantly shorter after revascularization, dismanteling a minor ST segment elevation. The ST elevation in lead V1 in anterior wall infarction and right bundle branch block may merge with the R' and cause a further QRS widening as an "equivalent" to the ST elevation.

  14. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis

    Science.gov (United States)

    Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J

    2016-01-01

    Objectives Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient populations. Hyperendemicity could result from increased transmissibility, longer duration of infectiousness, and/or higher pathogenic potential as compared with other lineages of the same species. The aim of our research is to quantitatively estimate these critical parameters for E. coli ST131 and K. pneumoniae ST258, in order to investigate whether E. coli ST131 and K. pneumoniae ST258 are truly hyperendemic clones. Primary outcome measures A systematic literature search was performed to assess the evidence of transmissibility, duration of infectiousness, and pathogenicity for E. coli ST131 and K. pneumoniae ST258. Meta-regression was performed to quantify these characteristics. Results The systematic literature search yielded 639 articles, of which 19 data sources provided information on transmissibility (E. coli ST131 n=9; K. pneumoniae ST258 n=10)), 2 on duration of infectiousness (E. coli ST131 n=2), and 324 on pathogenicity (E. coli ST131 n=285; K. pneumoniae ST258 n=39). Available data on duration of carriage and on transmissibility were insufficient for quantitative assessment. In multivariable meta-regression E. coli isolates causing infection were associated with ST131, compared to isolates only causing colonisation, suggesting that E. coli ST131 can be considered more pathogenic than non-ST131 isolates. Date of isolation, location and resistance mechanism also influenced the prevalence of ST131. E. coli ST131 was 3.2 (95% CI 2.0 to 5.0) times more pathogenic than non-ST131. For K. pneumoniae ST258 there were not enough data for meta-regression assessing the influence of colonisation versus infection on ST258 prevalence. Conclusions With the currently available data

  15. 46 CFR 7.85 - St. Simons Island, GA to Little Talbot Island, FL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false St. Simons Island, GA to Little Talbot Island, FL. 7.85... BOUNDARY LINES Atlantic Coast § 7.85 St. Simons Island, GA to Little Talbot Island, FL. (a) A line drawn from latitude 31°04.1′ N. longitude 81°16.7′ W. (St. Simons Lighted Whistle Buoy “ST S”) to latitude 30...

  16. Micro Learning: A Modernized Education System

    Directory of Open Access Journals (Sweden)

    Omer Jomah

    2016-03-01

    Full Text Available Learning is an understanding of how the human brain is wired to learning rather than to an approach or a system. It is one of the best and most frequent approaches for the 21st century learners. Micro learning is more interesting due to its way of teaching and learning the content in a small, very specific burst. Here the learners decide what and when to learn. Content, time, curriculum, form, process, mediality, and learning type are the dimensions of micro learning. Our paper will discuss about micro learning and about the micro-content management system. The study will reflect the views of different users, and will analyze the collected data. Finally, it will be concluded with its pros and cons. 

  17. The Impact of Multitasking Learning Environments in the Middle Grades

    Science.gov (United States)

    Drinkwine, Timothy

    2013-01-01

    This research study considers the status of middle school students in the 21st century in terms of their tendency to multitask in their daily lives and the overall influence this multitasking has on teaching and learning environments. Student engagement in the learning environment and students' various learning styles are discussed as primary…

  18. Topical application of ST266 reduces UV-induced skin damage

    Directory of Open Access Journals (Sweden)

    Guan L

    2017-11-01

    Full Text Available Linna Guan,1 Amanda Suggs,1 Emily Galan,1 Minh Lam,1 Elma D Baron1,2 1Department of Dermatology, Case Western Reserve University, 2Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA Abstract: Ultraviolet radiation (UVR has a significant impact on human skin and is the major environmental factor for skin cancer formation. It is also believed that 80% of the signs of skin aging are attributed to UVR. UVR induces inflammatory changes in the skin via the increase in oxidative stress, DNA damage vascular permeability, and fluctuation in a myriad of cytokines. Acutely, UVR causes skin inflammation and DNA damage, which manifest as sunburn (erythema. ST266 is the secretome of proprietary amnion-derived cells that have been shown to reduce inflammation and accelerate healing of various wounds by promoting migration of keratinocytes and fibroblasts in preclinical animal studies. We hypothesized that ST266 has anti-inflammatory effects that can be used to reduce ultraviolet (UV erythema and markers of inflammation. In this study, we examined the in vivo effects of ST266 on post UV-irradiated skin by measuring erythema, level of cyclobutane pyrimidine dimer (CPD, and expression level of xeroderma pigmentosum, complementation group A (XPA. We demonstrated that ST266 has the potential to reduce the acute effects of UV-induced skin damage when applied immediately after the initial exposure. In addition, ST266 is shown to reduce erythema, increase XPA DNA repair protein, and decrease damaged DNA. Keywords: ST266, photoaging, erythema, CPD, XPA, UV-induced DNA damage

  19. 77 FR 22574 - Filing Dates for the Washington Special Election In the 1st Congressional District

    Science.gov (United States)

    2012-04-16

    ... the 1st Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for... Special Primary and Special General Election on November 6, 2012, shall file a 12-day Pre-Primary Report... Elections shall file a 12-day Pre-Primary Report on July 26, 2012; a 12-day Pre-General Report on October 25...

  20. Idaho National Laboratory Quarterly Occurrence Analysis - 1st Quarter FY 2016

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Lisbeth Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 74 reportable events (16 from the 1st Qtr FY-16 and 58 from the prior three reporting quarters), as well as 35 other issue reports (including events found to be not reportable and Significant Category A and B conditions) identified at INL during the past 12 months (15 from this quarter and 20 from the prior three quarters).

  1. Mathematics Practicum at St. Olaf College: Project-Based Learning through Academic Civic Engagement

    Science.gov (United States)

    Sanft, Rebecca; Ziegler-Graham, Kathryn

    2018-01-01

    The Mathematics Practicum has been offered at St. Olaf College for over 30 years. The Practicum is a 4-week, January Interim course where three teams of five students work on consulting problems solicited from area businesses, government agencies, and non-profit organizations. These problems have significant mathematical, statistical, and…

  2. Proceedings of the 1st International Operational Modal Analysis Conference, April 26-27, 2005, Copenhagen, Denmark

    DEFF Research Database (Denmark)

    These proceedings contain approximately 100 papers presented at the 1st International Operational Modal Conference, Copenhagen, Denmark, April 26 - 27, 2005. The conference is jointly organised by Structural Vibration Systems (SVS), Aalborg, Brüel & Kjær Sound and Vibration Measurement A/S and th......These proceedings contain approximately 100 papers presented at the 1st International Operational Modal Conference, Copenhagen, Denmark, April 26 - 27, 2005. The conference is jointly organised by Structural Vibration Systems (SVS), Aalborg, Brüel & Kjær Sound and Vibration Measurement A....../S and the Department of Building Technology and Structural Engineering at Aalborg University. It is the first conference ever to focus solely on experimental modal analysis for cases where only the responses are measured. It was decided to hold the conference to generate interest in operational modal analysis (also...... effort and higher versatility. However, because the mathematical background was initially weak, computer power was insufficient and the equipment not sensitive enough for this kind of testing, the technology has only become popular during the last 3 - 4 years. For this reason, the first conference...

  3. Potentials of E-Learning as a Study Tool in Business Education in Nigerian Schools

    Science.gov (United States)

    Ojeaga, I. J.; Igbinedion, V. I.

    2012-01-01

    With advancement in information technology in the 21st century, e-learning has become an invaluable technology for teaching, learning and research in education. E-learning involves the use of technology to enhance learning including digital collaboration, satellite broadcasting, CD-ROMs amongst others. E-learning has so many advantages over the…

  4. 1st and 2nd Trimester Headsize in Fetuses with Congenital Heart Disease: A Cohort Study

    DEFF Research Database (Denmark)

    Lauridsen, Mette Høj; Petersen, Olav Bjørn; Vestergaard, Else Marie

    2014-01-01

    and screening for fetal malformations is carried out. Our cohort includes all fetuses in Western Denmark (2.9 million inhabitants) screened in between January 1st 2012 and December 31st 2013, diagnosed with any structural, non-syndromic congenital heart disease either during pregnancy or up to 6 months after......Background: Congenital heart disease (CHD) is associated with neuro-developmental disorders. The influence of CHD on the brain may be present in the fetus. We hypothesize that fetal cerebral growth is impaired as early as 2nd trimester. Aim: To investigate if fetal cerebral growth is associated...... birth. Results 276 fetuses with CHD were identified. 114 (41%) were genetically screened primarily by chromosomal microarray analysis (n=82). Fetuses with identified chromosomal abnormalities were excluded as were multiple gestation fetuses and fetuses with major extra cardiac malformations. Data from...

  5. Investigating the Quality of Project-Based Science and Technology Learning Environments in Elementary School: A Critical Review of Instruments

    Science.gov (United States)

    Thys, Miranda; Verschaffel, Lieven; Van Dooren, Wim; Laevers, Ferre

    2016-01-01

    This paper provides a systematic review of instruments that have the potential to measure the quality of project-based science and technology (S&T) learning environments in elementary school. To this end, a comprehensive literature search was undertaken for the large field of S&T learning environments. We conducted a horizontal bottom-up…

  6. Developing the Vision: An L4L Job Description for the 21st Century

    Science.gov (United States)

    Ballard, Susan

    2009-01-01

    The release of AASL's "Standards for the 21st-Century Learner" and "Empowering Learners: Guidelines for School Library Media Programs" has provided school library media specialists with the opportunity to "develop new visions for learning" (AASL 2009), and to rethink what their roles are, and what skills and characteristics are required of them to…

  7. PREFACE: 1st International Conference on Rheology and Modeling of Materials

    Science.gov (United States)

    Gömze, László A.

    2015-04-01

    Understanding the rheological properties of materials and their rheological behaviors during their manufacturing processes and in their applications in many cases can help to increase the efficiency and competitiveness not only of the finished goods and products but the organizations and societies also. The more scientific supported and prepared organizations develop more competitive products with better thermal, mechanical, physical, chemical and biological properties and the leading companies apply more competitive knowledge, materials, equipment and technology processes. The idea to organize in Hungary the 1st International Conference on Rheology and Modeling of Materials we have received from prospective scientists, physicists, chemists, mathematicians and engineers from Asia, Europe, North and South America including India, Korea, Russia, Turkey, Estonia, France, Italy, United Kingdom, Chile, Mexico and USA. The goals of ic-rmm1 the 1st International Conference on Rheology and Modeling of Materials are the following: • Promote new methods and results of scientific research in the fields of modeling and measurements of rheological properties and behavior of materials under processing and applications. • Change information between the theoretical and applied sciences as well as technical and technological implantations. • Promote the communication between the scientists of different disciplines, nations, countries and continents. The international conference ic-rmm1 provides a platform among the leading international scientists, researchers, PhD students and engineers for discussing recent achievements in measurement, modeling and application of rheology in materials technology and materials science of liquids, melts, solids, crystals and amorphous structures. Among the major fields of interest are the influences of material structures, mechanical stresses temperature and deformation speeds on rheological and physical properties, phase transformation of

  8. The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer

    Science.gov (United States)

    Munkley, Jennifer; Oltean, Sebastian; Vodák, Daniel; Wilson, Brian T.; Livermore, Karen E.; Zhou, Yan; Star, Eleanor; Floros, Vasileios I.; Johannessen, Bjarne; Knight, Bridget; McCullagh, Paul; McGrath, John; Crundwell, Malcolm; Skotheim, Rolf I.; Robson, Craig N.; Leung, Hing Y.; Harries, Lorna W.; Rajan, Prabhakar; Mills, Ian G.; Elliott, David J.

    2015-01-01

    Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal metastatic castration-resistant disease. Here we used RNA-Seq coupled with bioinformatic analyses of androgen-receptor (AR) binding sites and clinical PCa expression array data to identify ST6GalNAc1 as a direct and rapidly activated target gene of the AR in PCa cells. ST6GalNAc1 encodes a sialytransferase that catalyses formation of the cancer-associated sialyl-Tn antigen (sTn), which we find is also induced by androgen exposure. Androgens induce expression of a novel splice variant of the ST6GalNAc1 protein in PCa cells. This splice variant encodes a shorter protein isoform that is still fully functional as a sialyltransferase and able to induce expression of the sTn-antigen. Surprisingly, given its high expression in tumours, stable expression of ST6GalNAc1 in PCa cells reduced formation of stable tumours in mice, reduced cell adhesion and induced a switch towards a more mesenchymal-like cell phenotype in vitro. ST6GalNAc1 has a dynamic expression pattern in clinical datasets, being significantly up-regulated in primary prostate carcinoma but relatively down-regulated in established metastatic tissue. ST6GalNAc1 is frequently upregulated concurrently with another important glycosylation enzyme GCNT1 previously associated with prostate cancer progression and implicated in Sialyl Lewis X antigen synthesis. Together our data establishes an androgen-dependent mechanism for sTn antigen expression in PCa, and are consistent with a general role for the androgen receptor in driving important coordinate changes to the glycoproteome during PCa progression. PMID:26452038

  9. Problems in the Deployment of Learning Networks In Small Organizations

    NARCIS (Netherlands)

    Shankle, Dean E.; Shankle, Jeremy P.

    2006-01-01

    Please, cite this publication as: Shankle, D.E., & Shankle, J.P. (2006). Problems in the Deployment of Learning Networks In Small Organizations. Proceedings of International Workshop in Learning Networks for Lifelong Competence Development, TENCompetence Conference. March 30th-31st, Sofia, Bulgaria:

  10. 75 FR 21718 - Canadian National Railway Company and Grand Trunk Corporation-Control-EJ&E West Company 1

    Science.gov (United States)

    2010-04-26

    ... headquarters in Washington, DC. The purpose of the hearing is for Canadian National Railway Company (CN) to... Railway Company and Grand Trunk Corporation-- Control--EJ&E West Company \\1\\ \\1\\ This decision also... Room on the first floor of the Board's headquarters at Patriot's Plaza, 395 E Street, SW., Washington...

  11. Framework for 21st Century School Nursing Practice: Framing Professional Development.

    Science.gov (United States)

    Allen-Johnson, Ann

    2017-05-01

    The NASN Code of Ethics upholds that it is the responsibility of the school nurse to maintain competency and pursue personal and professional growth. Designing professional development activities that are relevant and support the needs of the school nurse can be a challenge. The Framework for 21st Century School Nursing Practice provides a model rooted in evidence-based standards of practice that can be utilized to assess an existing professional development program and identify gaps in learning opportunities. Nurse leaders can use the Framework for 21st Century Nursing Practice to provide a roadmap toward a professional development program that will be meaningful to school nurse staff, help restore or maintain joy in their practice, and allow them to achieve the goal of advancing the well-being, academic success, and lifelong achievement and health of students.

  12. The glycan-specific sulfotransferase (R77W)GalNAc-4-ST1 putatively responsible for peeling skin syndrome has normal properties consistent with a simple sequence polymorphisim.

    Science.gov (United States)

    Fiete, Dorothy; Mi, Yiling; Beranek, Mary; Baenziger, Nancy L; Baenziger, Jacques U

    2017-05-01

    Expanded access to DNA sequencing now fosters ready detection of site-specific human genome alterations whose actual significance requires in-depth functional study to rule in or out disease-causing mutations. This is a particular concern for genomic sequence differences in glycosyltransferases, whose implications are often difficult to assess. A recent whole-exome sequencing study identifies (c.229 C > T) in the GalNAc-4-ST1 glycosyltransferase (CHST8) as a disease-causing missense R77W mutation yielding the genodermatosis peeling skin syndrome (PSS) when homozygous. Cabral et al. (Genomics. 2012;99:202-208) cite this sequence change as reducing keratinocyte GalNAc-4-ST1 activity, thus decreasing glycosaminoglycan sulfation, as the mechanism for this blistering disorder. Such an identification could point toward potential clinical and/or prenatal diagnosis of a harmful medical condition. However, GalNAc-4-ST1 has minimal activity toward glycosaminoglycans, instead modifying terminal β1,4-linked GalNAc on N- and O-linked oligosaccharides on specific glycoproteins. We find expression, processing and catalytic activity of GalNAc-4-ST1 completely equivalent between wild type and (R77W) sulfotransferases. Moreover, keratinocytes have little or no GalNAc-4-ST1 mRNA, indicating that they do not express GalNAc-4-ST1. In addition, loss-of-function of GalNAc-4-ST1 primarily presents as reproductive system aberrations rather than skin effects. These findings, an allele frequency of 0.004357, and a 10-fold difference in prevalence of CHST8 (c.299 C > T, R77W) across different ethnic groups, suggest that this sequence represents a "passenger" distributed polymorphism, a simple sequence variant form of the enzyme having normal activity, rather than a "driver" disease-causing mutation that accounts for PSS. This study presents an example for guiding biomedical research initiatives, as well as medical and personal/family perspectives, regarding newly-identified genomic sequence

  13. Region and task-specific activation of Arc in primary motor cortex of rats following motor skill learning.

    Science.gov (United States)

    Hosp, J A; Mann, S; Wegenast-Braun, B M; Calhoun, M E; Luft, A R

    2013-10-10

    Motor learning requires protein synthesis within the primary motor cortex (M1). Here, we show that the immediate early gene Arc/Arg3.1 is specifically induced in M1 by learning a motor skill. Arc mRNA was quantified using a fluorescent in situ hybridization assay in adult Long-Evans rats learning a skilled reaching task (SRT), in rats performing reaching-like forelimb movement without learning (ACT) and in rats that were trained in the operant but not the motor elements of the task (controls). Apart from M1, Arc expression was assessed within the rostral motor area (RMA), primary somatosensory cortex (S1), striatum (ST) and cerebellum. In SRT animals, Arc mRNA levels in M1 contralateral to the trained limb were 31% higher than ipsilateral (pmotor skill learning in rats. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

  14. The Next Frontier in Making Disciples: 21st-Century Technology Use in CCCU Member Institutions

    Science.gov (United States)

    Boden, Karen E.

    2012-01-01

    An unprecedented opportunity exists for Christian colleges and universities to utilize 21st-century technology and the impact of globalization to broaden the use of distance learning for missional purposes through their educational offerings. Some institutions offer open education that allows those with Internet access to take courses at no cost…

  15. The U.S. Air Service in World War I. Volume III. The Battle of St. Mihiel

    Science.gov (United States)

    1979-01-01

    Headquarters: Station: La Ferte-sous-Jouarre, Department of Seine - et - Marne , France. Commander: Gei. John J. Pershing, U.S. Army Staff: Chiei of...in its series on the operations of the various U.S. divisions in France,7 and by maps that the Service Historique of France published with French...region between the Aisne and Marne rivers when the Allied commanders met on 24 July 1918 at Bombon, the headquarters of Marshal Ferdi- nand Foch, the

  16. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2016

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-06-06

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2016. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  17. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2017; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2017

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2017-06-14

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2017. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  18. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2015; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2015

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-07-07

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2015. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  19. St2-80: a new FISH marker for St genome and genome analysis in Triticeae.

    Science.gov (United States)

    Wang, Long; Shi, Qinghua; Su, Handong; Wang, Yi; Sha, Lina; Fan, Xing; Kang, Houyang; Zhang, Haiqin; Zhou, Yonghong

    2017-07-01

    The St genome is one of the most fundamental genomes in Triticeae. Repetitive sequences are widely used to distinguish different genomes or species. The primary objectives of this study were to (i) screen a new sequence that could easily distinguish the chromosome of the St genome from those of other genomes by fluorescence in situ hybridization (FISH) and (ii) investigate the genome constitution of some species that remain uncertain and controversial. We used degenerated oligonucleotide primer PCR (Dop-PCR), Dot-blot, and FISH to screen for a new marker of the St genome and to test the efficiency of this marker in the detection of the St chromosome at different ploidy levels. Signals produced by a new FISH marker (denoted St 2 -80) were present on the entire arm of chromosomes of the St genome, except in the centromeric region. On the contrary, St 2 -80 signals were present in the terminal region of chromosomes of the E, H, P, and Y genomes. No signal was detected in the A and B genomes, and only weak signals were detected in the terminal region of chromosomes of the D genome. St 2 -80 signals were obvious and stable in chromosomes of different genomes, whether diploid or polyploid. Therefore, St 2 -80 is a potential and useful FISH marker that can be used to distinguish the St genome from those of other genomes in Triticeae.

  20. 1st International Conference on Calcined Clays for Sustainable Concrete

    CERN Document Server

    Favier, Aurélie

    2015-01-01

    This volume focuses on research and practical issues linked to Calcined Clays for Sustainable Concrete. The main subjects are geology of clays, hydration and performance of blended systems with calcined clays, alkali activated binders, economic and environmental impacts of the use of calcined clays in cement based materials. Topics addressed in this book include the influence of processing on reactivity of calcined clays, influence of clay mineralogy on reactivity, geology of clay deposits, Portland-calcined clay systems, hydration, durability, performance, Portland-calcined clay-limestone systems, hydration, durability, performance, calcined clay-alkali systems, life cycle analysis, economics and environmental impact of use of calcined clays in cement and concrete, and field applications. This book compiles the different contributions of the 1st International Conference on Calcined Clays for Sustainable Concrete, which took place in Lausanne, Switzerland, June, 23-25, 2015.The papers present the latest  res...