42 CFR 93.213 - Institution.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Institution. 93.213 Section 93.213 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH...

49 CFR 213.110 - Gage restraint measurement systems.

Science.gov (United States)

2010-10-01

... requirements specified in §§ 213.109 and 213.127. (5) If the PTLF becomes non-functional or is missing, the... and fastener requirements specified in §§ 213.109 and 213.127 provided that— (1) The track owner... the minimum design requirements of a GRMS vehicle which specify that— (1) Gage restraint shall be...

32 CFR 724.213 - Attendance of witnesses.

Science.gov (United States)

2010-07-01

... BOARD Authority/Policy for Departmental Discharge Review § 724.213 Attendance of witnesses. Arrangement for attendance of witnesses testifying in behalf of the applicant at discharge review hearings is the... 32 National Defense 5 2010-07-01 2010-07-01 false Attendance of witnesses. 724.213 Section 724.213...

30 CFR 75.213 - Roof support removal.

Science.gov (United States)

2010-07-01

... mining experience shall perform permanent roof support removal work. (b) Prior to the removal of... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Roof support removal. 75.213 Section 75.213... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Roof Support § 75.213 Roof support removal. (a)(1) All...

In Vitro comparison of 213Bi- and 177Lu-radiation for peptide receptor radionuclide therapy.

Science.gov (United States)

Chan, Ho Sze; de Blois, Erik; Morgenstern, Alfred; Bruchertseifer, Frank; de Jong, Marion; Breeman, Wouter; Konijnenberg, Mark

2017-01-01

Absorbed doses for α-emitters are different from those for β-emitters, as the high linear energy transfer (LET) nature of α-particles results in a very dense energy deposition over a relatively short path length near the point of emission. This highly localized and therefore high energy deposition can lead to enhanced cell-killing effects at absorbed doses that are non-lethal in low-LET type of exposure. Affinities of DOTA-DPhe1-Tyr3-octreotate (DOTATATE), 115In-DOTATATE, 175Lu-DOTATATE and 209Bi-DOTATATE were determined in the K562-SST2 cell line. Two other cell lines were used for radiation response assessment; BON and CA20948, with a low and high expression of somatostatin receptors, respectively. Cellular uptake kinetics of 111In-DOTATATE were determined in CA20948 cells. CA20948 and BON were irradiated with 137Cs, 177Lu-DTPA, 177Lu-DOTATATE, 213Bi-DTPA and 213Bi-DOTATATE. Absorbed doses were calculated using the MIRDcell dosimetry method for the specific binding and a Monte Carlo model of a cylindrical 6-well plate geometry for the exposure by the radioactive incubation medium. Absorbed doses were compared to conventional irradiation of cells with 137Cs and the relative biological effect (RBE) at 10% survival was calculated. IC50 of (labelled) DOTATATE was in the nM range. Absorbed doses up to 7 Gy were obtained by 5.2 MBq 213Bi-DOTATATE, in majority the dose was caused by α-particle radiation. Cellular internalization determined with 111In-DOTATATE showed a linear relation with incubation time. Cell survival after exposure of 213Bi-DTPA and 213Bi-DOTATATE to BON or CA20948 cells showed a linear-exponential relation with the absorbed dose, confirming the high LET character of 213Bi. The survival of CA20948 after exposure to 177Lu-DOTATATE and the reference 137Cs irradiation showed the typical curvature of the linear-quadratic model. 10% Cell survival of CA20948 was reached at 3 Gy with 213Bi-DOTATATE, a factor 6 lower than the 18 Gy found for 177Lu

In Vitro comparison of 213Bi- and 177Lu-radiation for peptide receptor radionuclide therapy.

Directory of Open Access Journals (Sweden)

Ho Sze Chan

Full Text Available Absorbed doses for α-emitters are different from those for β-emitters, as the high linear energy transfer (LET nature of α-particles results in a very dense energy deposition over a relatively short path length near the point of emission. This highly localized and therefore high energy deposition can lead to enhanced cell-killing effects at absorbed doses that are non-lethal in low-LET type of exposure. Affinities of DOTA-DPhe1-Tyr3-octreotate (DOTATATE, 115In-DOTATATE, 175Lu-DOTATATE and 209Bi-DOTATATE were determined in the K562-SST2 cell line. Two other cell lines were used for radiation response assessment; BON and CA20948, with a low and high expression of somatostatin receptors, respectively. Cellular uptake kinetics of 111In-DOTATATE were determined in CA20948 cells. CA20948 and BON were irradiated with 137Cs, 177Lu-DTPA, 177Lu-DOTATATE, 213Bi-DTPA and 213Bi-DOTATATE. Absorbed doses were calculated using the MIRDcell dosimetry method for the specific binding and a Monte Carlo model of a cylindrical 6-well plate geometry for the exposure by the radioactive incubation medium. Absorbed doses were compared to conventional irradiation of cells with 137Cs and the relative biological effect (RBE at 10% survival was calculated.IC50 of (labelled DOTATATE was in the nM range. Absorbed doses up to 7 Gy were obtained by 5.2 MBq 213Bi-DOTATATE, in majority the dose was caused by α-particle radiation. Cellular internalization determined with 111In-DOTATATE showed a linear relation with incubation time. Cell survival after exposure of 213Bi-DTPA and 213Bi-DOTATATE to BON or CA20948 cells showed a linear-exponential relation with the absorbed dose, confirming the high LET character of 213Bi. The survival of CA20948 after exposure to 177Lu-DOTATATE and the reference 137Cs irradiation showed the typical curvature of the linear-quadratic model. 10% Cell survival of CA20948 was reached at 3 Gy with 213Bi-DOTATATE, a factor 6 lower than the 18 Gy found

Dicty_cDB: CFE213 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available CF (Link to library) CFE213 (Link to dictyBase) - - - Contig-U16381-1 CFE213F (Link... to Original site) CFE213F 111 - - - - - - Show CFE213 Library CF (Link to library) Clone ID CFE213 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16381-1 Original site URL http://dict... E Sequences producing significant alignments: (bits) Value N AC115685 |AC115685.1 Dict...yostelium discoideum chromosome 2 map 4718821-4752388 strain AX4, complete sequence. 80 9e-24 3 X51892 |X51892.1 Dict

21 CFR 21.3 - Definitions.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Definitions. 21.3 Section 21.3 Food and Drugs FOOD... products regulated by the Food and Drug Administration or with which the Food and Drug Administration has business dealings. Any such business enterprise that is identified by the name of one or more individuals...

19 CFR 213.5 - Access to Commission resources.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Access to Commission resources. 213.5 Section 213.5 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE TRADE REMEDY ASSISTANCE § 213.5 Access to Commission resources. Commission resources, in...

Nuclear Data Sheets for A=213

International Nuclear Information System (INIS)

Basunia, M.S.

2007-01-01

Evaluated spectroscopic data and level schemes from radioactive decay and nuclear reaction studies are presented for all nuclei with mass number A=213. This evaluation for A=213 supersedes the earlier one by Y. A. Akovali (1992Ak01), published in Nuclear Data Sheets 66, 237 (1992)

25 CFR 213.43 - Relinquishment of Government supervision.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Relinquishment of Government supervision. 213.43 Section 213.43 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF RESTRICTED LANDS OF MEMBERS OF FIVE CIVILIZED TRIBES, OKLAHOMA, FOR MINING Removal of Restrictions § 213.43 Relinquishment of Government supervision....

5 CFR 213.3199 - Temporary organizations.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Temporary organizations. 213.3199 Section... SERVICE Excepted Schedules Schedule A § 213.3199 Temporary organizations. Positions on the staffs of temporary organizations, as defined in 5 U.S.C. 3161(a). Appointments may not exceed 3 years, but temporary...

19 CFR 213.6 - Information concerning assistance.

Science.gov (United States)

2010-04-01

... 213.6 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE TRADE REMEDY ASSISTANCE § 213.6 Information concerning assistance. Any person may.... International Trade Commission, 500 E Street SW., Washington, DC 20436. ...

19 CFR 213.1 - Purpose and applicability of part.

Science.gov (United States)

2010-04-01

... 213.1 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE TRADE REMEDY ASSISTANCE § 213.1 Purpose and applicability of part. (a) Section 339 of... benefits available under the trade laws identified in § 213.2(b) and the procedures to be followed and...

7 CFR 1280.213 - Investment of funds.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Investment of funds. 1280.213 Section 1280.213 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... thereof, in any interest-bearing account or certificate of deposit of a financial institution that is a...

25 CFR 213.33 - Diligence and prevention of waste.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Diligence and prevention of waste. 213.33 Section 213.33... LANDS OF MEMBERS OF FIVE CIVILIZED TRIBES, OKLAHOMA, FOR MINING Operations § 213.33 Diligence and prevention of waste. The lessee shall exercise diligence in drilling and operating wells for oil and gas on...

40 CFR 86.213-94 - Fuel specifications.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Fuel specifications. 86.213-94 Section 86.213-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... 1994 and Later Model Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium...

40 CFR 86.213-04 - Fuel specifications.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Fuel specifications. 86.213-04 Section 86.213-04 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... 1994 and Later Model Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium...

40 CFR 86.213-11 - Fuel specifications.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Fuel specifications. 86.213-11 Section 86.213-11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... 1994 and Later Model Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium...

13 CFR 500.213 - Termination of obligations.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Termination of obligations. 500.213 Section 500.213 Business Credit and Assistance EMERGENCY OIL AND GAS GUARANTEED LOAN BOARD... the Application, the Guarantee or the Loan Documents; (5) A Lender fails to make a demand for payment...

Pharmacological characterization of canine melancortin-4 receptor and its natural variant V213F.

Science.gov (United States)

Yan, J; Tao, Y-X

2011-08-01

Dogs have become one of the most important companion animals in modern society. However, it is estimated that 20% to 40% of owned dogs are obese, suggesting that obesity has become one of the most important canine health problem. In addition, obesity in dogs also leads to type II diabetes. Because the melanocortin-4 receptor (MC4R) has been shown to be essential in maintaining energy homeostasis in several different species, including rodents and humans, we initiated studies toward elucidating the roles of MC4R in obesity pathogenesis in dogs. Canine MC4R has been cloned, and a missense variant V213F was identified. We designed primers and successfully cloned canine MC4R and generated the variant V213F by site-directed mutagenesis. The objective of this study was to investigate the pharmacological properties of canine MC4R and its natural variant V213F. We measured ligand binding and signaling properties with the use of both natural and synthetic ligands. Human MC4R was also included in the experiments for comparison. Both wild-type canine MC4R and its natural variant V213F functioned normally in terms of binding and signaling. Of the ligands we used, [Nle(4), D-Phe(7)]-α-melanocyte-stimulating hormone is the most potent ligand. We conclude that the cloned canine MC4R is a functional receptor, and the natural variant V213F does not have any functional defect and therefore is not likely to cause obesity in dogs. Copyright © 2011 Elsevier Inc. All rights reserved.

22 CFR 1203.735-213 - Recommendations for employment.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Recommendations for employment. 1203.735-213 Section 1203.735-213 Foreign Relations UNITED STATES INTERNATIONAL DEVELOPMENT COOPERATION AGENCY EMPLOYEE... investigate applicants for employment. A principal officer in answer to a letter of inquiry from outside the U...

Methemoglobin-forming effect and its role in the mechanism of action of some radioprotectors of benzo-2,1,3-thiadiazole class

International Nuclear Information System (INIS)

Vladimirov, V.G.; Chigareva, N.G.; Belen'kaya, I.A.; Strel'nikov, Yu.E.

1977-01-01

The ability of some benzo-2,1,3-tiadiazole derivatives to form methemoglobin in blood has been investigated. It has been shown that 30 min after intraperitoneal administration to mice of radioprotective doses of the preparations, the methemoglobin level in blood does not exceed 5%. After administration of a toxic dose of 4-aminobenzo-2,1,3-tiadiazole, the amount of methemoglobin in the mouse blood makes 14%. After per os administration of 4-aminobenzo-2,1,3-tiadiazole to dogs methemoglobin content of blood makes almost 50% which can provide a radioprotective action of this compound. Using substances preventing oxidation of hemoglobin to methemoglobin (isonicotinic acid hydrazide and 2-methoxy-9-phenazin sulphate) it has been shown that methemoglobin, formed in the mouse blood, does not play a leading part in manifestation of radioprotective and toxic properties of 4-aminobenzo-2,1,3-tiadiazole

22 CFR 213.21 - Employee salary offset-general.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Employee salary offset-general. 213.21 Section... § 213.21 Employee salary offset—general. (a) Purpose. This section establishes USAID's policies and... account of an employee. (b) Scope. The provisions of this section apply to collection by salary offset...

22 CFR 213.13 - Interest and charges pending waiver or review.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Interest and charges pending waiver or review. 213.13 Section 213.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT CLAIMS COLLECTION Collection § 213.13 Interest and charges pending waiver or review. Interest, penalty charges and...

42 CFR 57.213a - Loan cancellation reimbursement.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Loan cancellation reimbursement. 57.213a Section 57... Professions Student Loans § 57.213a Loan cancellation reimbursement. (a) For loans made prior to October 22... credited to this insurance fund), and used only to reimburse the school for the institutional share of any...

20 CFR 410.213 - Duration of entitlement; child.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Duration of entitlement; child. 410.213...; Filing of Claims and Evidence § 410.213 Duration of entitlement; child. (a) An individual is entitled to benefits as a child for each month beginning with the first month in which all of the conditions of...

25 CFR 213.19 - Crediting advance annual payments.

Science.gov (United States)

2010-04-01

... been made. No refund of such advance payments made under any lease will be allowed in the event the royalty on production is not sufficient to equal such advance payment; nor will any part of the moneys so... 25 Indians 1 2010-04-01 2010-04-01 false Crediting advance annual payments. 213.19 Section 213.19...

"Wine-Dark Sea" in an Organic Flow Battery: Storing Negative Charge in 2,1,3-Benzothiadiazole Radicals Leads to Improved Cyclability

Energy Technology Data Exchange (ETDEWEB)

Duan, Wentao; Huang, Jinhua; Kowalski, Jeffrey A.; Shkrob, Ilya A.; Vijayakumar, M.; Walter, Eric; Pan, Baofei; Yang, Zheng; Milshtein, Jarrod D.; Li, Bin; Liao, Chen; Zhang, Zhengcheng; Wang, Wei; Liu, Jun; Moore, Jeffery S.; Brushett, Fikile R.; Zhang, Lu; Wei, Xiaoliang

2017-04-19

A highly soluble, readily accessible, redox-active organic material, 2,1,3-benzothiadiazole, is demonstrated as a novel anolyte material to enable exceptional cyclability in a full-cell organic redox flow battery. This material discovery represents a significant progress toward promising next-generation energy storage.

19 CFR 213.3 - Determination of small business eligibility.

Science.gov (United States)

2010-04-01

... Section 213.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE TRADE REMEDY ASSISTANCE § 213.3 Determination of small business eligibility. (a... technical assistance from joint applicants, trade associations and unions. If several businesses jointly or...

High-efficency stable 213-nm generation for LASIK application

Science.gov (United States)

Wang, Zhenglin; Alameh, Kamal; Zheng, Rong

2005-01-01

213nm Solid-state laser technology provides an alternative method to replace toxic excimer laser in LASIK system. In this paper, we report a compact fifth harmonic generation system to generate high pulse energy 213nm laser from Q-switched Nd:YAG laser for LASIK application based on three stages harmonic generation procedures. A novel crystal housing was specifically designed to hold the three crystals with each crystal has independent, precise angular adjustment structure and automatic tuning control. The crystal temperature is well maintained at ~130°C to improve harmonic generation stability and crystal operation lifetime. An output pulse energy 35mJ is obtained at 213nm, corresponding to total conversion efficiency ~10% from 1064nm pump laser. In system verification tests, the 213nm output power drops less than 5% after 5 millions pulse shots and no significant damage appears in the crystals.

Antimicrobial activity and mechanism of PDC213, an endogenous peptide from human milk

International Nuclear Information System (INIS)

Sun, Yazhou; Zhou, Yahui; Liu, Xiao; Zhang, Fan; Yan, Linping; Chen, Ling; Wang, Xing; Ruan, Hongjie; Ji, Chenbo; Cui, Xianwei; Wang, Jiaqin

2017-01-01

Human milk has always been considered an ideal source of elemental nutrients to both preterm and full term infants in order to optimally develop the infant's tissues and organs. Recently, hundreds of endogenous milk peptides were identified in human milk. These peptides exhibited angiotensin-converting enzyme inhibition, immunomodulation, or antimicrobial activity. Here, we report the antimicrobial activity and mechanism of a novel type of human antimicrobial peptide (AMP), termed PDC213 (peptide derived from β-Casein 213-226 aa). PDC213 is an endogenous peptide and is present at higher levels in preterm milk than in full term milk. The inhibitory concentration curve and disk diffusion tests showed that PDC213 had obvious antimicrobial against S. aureus and Y. enterocolitica, the common nosocomial pathogens in neonatal intensive care units (NICUs). Fluorescent dye methods, electron microscopy experiments and DNA-binding activity assays further indicated that PDC213 can permeabilize bacterial membranes and cell walls rather than bind intracellular DNA to kill bacteria. Together, our results suggest that PDC213 is a novel type of AMP that warrants further investigation. - Highlights: • PDC213 is an endogenous peptide presenting higher levels in preterm milk. • PDC213 showed obvious antimicrobial against S. aereus and Y. enterocolitica. • PDC213 can permeabilize bacterial membranes and cell walls to kill bacterias. • PDC213 is a novel type of antimicrobial peptides worthy further investigation.

49 CFR 1544.213 - Use of explosives detection systems.

Science.gov (United States)

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Use of explosives detection systems. 1544.213...: AIR CARRIERS AND COMMERCIAL OPERATORS Operations § 1544.213 Use of explosives detection systems. (a... explosives detection system approved by TSA to screen checked baggage on international flights. (b) Signs and...

49 CFR 40.213 - What training requirements must STTs and BATs meet?

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false What training requirements must STTs and BATs meet? 40.213 Section 40.213 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Alcohol Testing Personnel § 40.213 What training requirements must STTs and BATs meet? To be...

45 CFR 213.5 - Filing and service of papers.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Filing and service of papers. 213.5 Section 213.5... and service of papers. (a) All papers in the proceedings shall be filed with the FSA Hearing Clerk, in...) All papers in the proceedings shall be served on all parties by personal delivery or by mail. Service...

47 CFR 213.4 - Definitions.

Science.gov (United States)

2010-10-01

... Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL GOVERNMENT AND PUBLIC CORRESPONDENCE TELECOMMUNICATIONS PRECEDENCE SYSTEM § 213.4 Definitions. As used herein: (a) Public... which messages and calls are processed. Transmission of information and call completion is therefore to...

22 CFR 213.3 - Loans, guarantees, sovereign and interagency claims.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Loans, guarantees, sovereign and interagency claims. 213.3 Section 213.3 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT CLAIMS COLLECTION... thereof, or any public international organization; (d) Claims where the CFO determines that the...

19 CFR 213.4 - Disclosure of receipt of technical assistance.

Science.gov (United States)

2010-04-01

....4 Section 213.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE TRADE REMEDY ASSISTANCE § 213.4 Disclosure of receipt of technical assistance. An... received technical assistance from the Trade Remedy Assistance Office in any resulting petition, complaint...

22 CFR 213.37 - Referrals to the Department of Justice.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Referrals to the Department of Justice. 213.37... Department of Justice § 213.37 Referrals to the Department of Justice. (a) The CFO, through the FMS cross... of Justice's Nationwide Central Intake Facility as required by the Claims Collection Litigation...

42 CFR 405.213 - Re-evaluation of a device categorization.

Science.gov (United States)

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Re-evaluation of a device categorization. 405.213... Decisions That Relate to Health Care Technology § 405.213 Re-evaluation of a device categorization. (a... experimental/investigational (Category A) may request re-evaluation of the categorization decision. (2) A...

49 CFR 213.317 - Waivers.

Science.gov (United States)

2010-10-01

... TRANSPORTATION TRACK SAFETY STANDARDS Train Operations at Track Classes 6 and Higher § 213.317 Waivers. (a) Any... railroad safety, the Administrator may grant the waiver subject to any conditions the Administrator deems necessary. Where a waiver is granted, the Administrator publishes a notice containing the reasons for...

49 CFR 234.213 - Grounds.

Science.gov (United States)

2010-10-01

... Maintenance Standards § 234.213 Grounds. Each circuit that affects the proper functioning of a highway-rail... in the circuit. This requirement does not apply to: circuits that include track rail; alternating current power distribution circuits that are grounded in the interest of safety; and common return wires...

Actinium-225 and Bismuth-213 Alpha Particle Immunotherapy of Cancer

International Nuclear Information System (INIS)

Scheinberg, D.

2013-01-01

Nuclides with appropriate half-lives and emission characteristics that would be potent enough to kill neoplastic cells in the small quantities that reach targets in vivo, include the high linear energy transfer (LET) alpha emitters such as Actinium-225 and Bi-213. We developed methods for the attachment of radiometals via bifunctional chelates to monoclonal antibodies (mAb) without loss of immunoreactivity. We developed alphaemitting Bi-213 lintuzumab constructs, characterized and qualified them in preclinical models, and took them into human clinical trials in patients with AML. Safety, anti-leukemic activity, and complete responses (CR’s) have been demonstrated through phase 2 trilas. Bi-213 is produced in a portable small generator device based on Ac- 225 in the hospital nuclear medicine lab. The isotope is then purified, attached to the antibody, and the product is qualified and processed. Despite this success, the major obstacle to the widespread use of these drugs remains the short 213 Bi half-life (46 minutes), which poses a large logistical hurdle before injection and limits its delivery to only the most accessible cancer cells after injection

49 CFR 213.307 - Class of track: operating speed limits.

Science.gov (United States)

2010-10-01

... requirements for its intended class, it is to be reclassified to the next lower class of track for which it... 49 Transportation 4 2010-10-01 2010-10-01 false Class of track: operating speed limits. 213.307... Higher § 213.307 Class of track: operating speed limits. (a) Except as provided in paragraph (b) of this...

The synthesis of [2-13C]2-nitropropane at room temperature and at atmospheric pressure

OpenAIRE

Jacquemijns M; Zomer G

1990-01-01

In this report the synthesis of [2-13C]2-nitropropane at room temperature is described. [2-13C]Acetone was converted into the oxime with hydroxy hydrochloridelamine and sodium carbonate. Treatment with hypobromic acid resulted in 2-13C]2-bromo-2-nitropropane. Hydrogenation with sodium borohydride gave [2-13C]2-nitropropane in 14,3% overall yield.

Gamma-ray response of NE-213 measured between 2 and 11.5 MeV

International Nuclear Information System (INIS)

Ingersoll, D.T.; Wehring, B.W.; Starr, R.D.

1976-01-01

Because of the capability to discriminate between neutrons and gamma rays, NE-213 scintillators are useful as both fast-neutron and gamma-ray spectrometers. However, measured NE-213 Compton-recoil spectra require unfolding to yield gamma-ray energy spectra which entails a detailed knowledge of the gamma-ray response of the NE-213 detector system. Absolute measurements of the gamma-ray response of an NE-213 scintillator in the energy range of 2 to 11.5 MeV were made. The measurements were made using the University of Illinois superconducting electron microtron equipped with a gamma-ray monochromator. The response measurements will be used to construct a gamma-ray response matrix for NE-213 to be used with the FORIST unfolding code

Experimental Studies for the VVER-440/213 Bubble Condenser System for Kola NPP at the Integral Test Facility BC V-213

International Nuclear Information System (INIS)

Blinkov, V.N.; Melikhov, O.I.; Melikhov, V.I.; Davydov, M.V.; Wolff, H.; Arndt, S.

2012-01-01

In the frame of Tacis Project R2.01/99, which was running from 2003 to 2005, the bubble condenser system of Kola NPP (unit 3) was qualified at the integral test facility BC V-213. Three LB LOCA tests, two MSLB tests, and one SB LOCA test were performed. The appropriate test scenarios for BC V-213 test facility, modeling accidents in the Kola NPP unit 3, were determined with pretest calculations. Analysis of test results has shown that calculated initial conditions and test scenarios were properly reproduced in the tests. The detailed posttest analysis of the tests performed at BC V-213 test facility was aimed to validate the COCOSYS code for the calculation of thermohydraulic processes in the hermetic compartments and bubble condenser. After that the validated COCOSYS code was applied to NPP calculations for Kola NPP (unit 3). Results of Tacis R2.01/99 Project confirmed the bubble condenser functionality during large and small break LOCAs and MSLB accidents. Maximum loads were reached in the LB LOCA case. No condensation oscillations were observed.

LabVIEW Data Acquisition for NE213 Neutron Detector

International Nuclear Information System (INIS)

Gangadharan, Dhevan

2003-01-01

A neutron spectroscopy system based on a NE213 liquid scintillation detector at the Stanford Linear Accelerator Center measures neutron energies from a few MeV up to 800 MeV. The neutrons are produced from the electron beam and target interactions. The NE 213 scintillator, coupled with a Photomultiplier Tube (PMT), detects and converts radiation into electric pulses for signal processing. Signals are processed through Nuclear Instrument Modules (NIM) and Computer Automated Measurement and Control (CAMAC) modules. The processed pulses are then fed into a CAMAC analog to digital converter module (ADC). The ADC classifies the incoming analog pulses into one of 2048 digital channels. Data acquisition (DAQ) software based on LabVIEW version 7.0 acquires and organizes data from the CAMAC ADC. The DAQ system presents a spectrum showing a relationship between pulse events and respective charge (digital channel number). Various photon sources, such as Co-60, Y-88, and AmBe-241, are used to calibrate the NE213 detector. For each source, a Compton edge and reference energy in MeVee is obtained, resulting in a calibration curve. This project is focused on the development of a DAQ system and control setup to collect and process information from a NE213 liquid scintillation detector. A manual is also created to document the process of the development and interpretation of the LabVIEW-based DAQ system

24 CFR 213.259a - Premiums-mortgages insured pursuant to section 238(c) of the Act.

Science.gov (United States)

2010-04-01

.... All of the provisions of §§ 213.253 through 213.259 governing mortgage insurance premiums shall apply... mortgage insurance premiums due on such mortgages in accordance with §§ 213.253 through 213.259 shall be... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Premiums-mortgages insured pursuant...

33 CFR 117.213 - New Haven Harbor, Quinnipiac and Mill Rivers.

Science.gov (United States)

2010-07-01

... Mill Rivers. 117.213 Section 117.213 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Haven Harbor, Quinnipiac and Mill Rivers. The draws of the Tomlinson bridge, mile 0.0, the Ferry Street... bridge, mile 0.4 across Mill River, shall operate as follows: (a) The draws shall open on signal; except...

LabVIEW DAQ for NE213 Neutron Detector

International Nuclear Information System (INIS)

Al-Adeeb, Mohammed

2003-01-01

A neutron spectroscopy system, based on a NE213 liquid scintillation detector, to be placed at the Stanford Linear Accelerator Center to measure neutron spectra from a few MeV up to 800 MeV, beyond shielding. The NE213 scintillator, coupled with a Photomultiplier Tube (PMT), detects and converts radiation into current for signal processing. Signals are processed through Nuclear Instrument Modules (NIM) and Computer Automated Measurement and Control (CAMAC) modules. CAMAC is a computer automated data acquisition and handling system. Pulses are properly prepared and fed into an analog to digital converter (ADC), a standard CAMAC module. The ADC classifies the incoming analog pulses into 1 of 2048 digital channels. Data acquisition (DAQ) software based on LabVIEW, version 7.0, acquires and organizes data from the CAMAC ADC. The DAQ system presents a spectrum showing a relationship between pulse events and respective charge (digital channel number). Various photon sources, such as Co-60, Y-88, and AmBe-241, are used to calibrate the NE213 detector. For each source, a Compton edge and reference energy [units of MeVee] is obtained. A complete calibration curve results (at a given applied voltage to the PMT and pre-amplification gain) when the Compton edge and reference energy for each source is plotted. This project is focused to development of a DAQ system and control setup to collect and process information from a NE213 liquid scintillation detector. A manual is created to document the process of the development and interpretation of the LabVIEW-based DAQ system. Future high-energy neutron measurements can be referenced and normalized according to this calibration curve

45 CFR 213.11 - Notice of hearing or opportunity for hearing.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Notice of hearing or opportunity for hearing. 213.11 Section 213.11 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES PRACTICE AND PROCEDURE FOR HEARINGS TO STATE...

13 CFR 120.213 - What fixed interest rates may a Lender charge?

Science.gov (United States)

2010-01-01

... Lender charge? 120.213 Section 120.213 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... have a reasonable fixed interest rate. SBA periodically publishes the maximum allowable rate in the... government determines the interest rate on direct loans. SBA publishes the rate periodically in the Federal...

24 CFR 213.275 - Nature of the Cooperative Management Housing Insurance Fund.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Nature of the Cooperative Management Housing Insurance Fund. 213.275 Section 213.275 Housing and Urban Development Regulations Relating... Nature of the Cooperative Management Housing Insurance Fund. The Cooperative Management Housing Insurance...

5 CFR 213.3301 - Positions of a confidential or policy-determining nature.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Positions of a confidential or policy-determining nature. 213.3301 Section 213.3301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL... or policy-determining nature. (a) Upon specific authorization by OPM, agencies may make appointments...

The synthesis of [2-13C]2-nitropropane at room temperature and at atmospheric pressure

NARCIS (Netherlands)

Jacquemijns M; Zomer G

1990-01-01

In this report the synthesis of [2-13C]2-nitropropane at room temperature is described. [2-13C]Acetone was converted into the oxime with hydroxy hydrochloridelamine and sodium carbonate. Treatment with hypobromic acid resulted in 2-13C]2-bromo-2-nitropropane. Hydrogenation with sodium borohydride

Phenotype abnormality: 213 [Arabidopsis Phenome Database[Archive

Lifescience Database Archive (English)

Full Text Available 213 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u719i decreased sensitivity toward under influ...ence of brassinosteroid ... decreased sensitivity toward ... brassinosteroid ...

Transformations of lead 1,3-propylenediaminetetraacetate to its MOF products for the selective adsorption of methanol

Energy Technology Data Exchange (ETDEWEB)

Dai, Jun-Wei; Li, Xing; Zheng, Jian-Mei; Dong, Xin, E-mail: dxin@xmu.edu.cn; Zhou, Zhao-Hui, E-mail: zhzhou@xmu.edu.cn

2016-05-15

Water soluble coordination polymer of potassium lead 1,3-propylenediaminetetraacetate {K_4[Pb_2(1,3-pdta)_2]·6H_2O}{sub n} (1) and its insoluble products {[Pb(1,3-H_2pdta)(H_2O)]·2H_2O}{sub n} (2), {[Pb_2(1,3-pdta)(H_2O)_4]·4H_2O}{sub n} (3) and [Pb{sub 2}(1,3-pdta)(H{sub 2}O){sub 2}]{sub n} (4) were obtained from the direct reactions of lead nitrate with 1,3-propylenediaminetetraacetic acid in different conditions (1,3-H{sub 4}pdta=1,3-propylenediaminetetraacetic acid). The former 1 could be converted to the insoluble products of {[Pb_2(1,3-pdta)(H_2O)_4]·4H_2O}{sub n} (3) and [Pb{sub 2}(1,3-pdta)(H{sub 2}O){sub 2}]{sub n} (4) in weak acidic solution. The complexes have been full characterized by EA, FT-IR, solution and solid state {sup 13}C NMR spectra, thermogravimetric and structural analyses. Interestingly, 3 contains a unique (H{sub 2}O){sub 26} cluster and a 5.2 Å pore after eliminating the guest water molecules, which exhibits reversible adsorption for methanol. This is confirmed by PXRD and solid state {sup 13}C NMR analyses. Nano-confined methanol in microporous structure has been observed based on the large downfield shift of {sup 13}C NMR signal (Δδ 9.72 ppm), attributing to the methyl group in methanol. - Graphical abstract: Water soluble coordination polymer K{sub 4n}[Pb{sub 2}(1,3-pdta){sub 2}]{sub n}·6nH{sub 2}O (1) is converted to its insoluble product [Pb{sub 2}(1,3-pdta)(H{sub 2}O){sub 4}]{sub n}·4nH{sub 2}O (3), which contains a unique (H{sub 2}O){sub 26} cluster and exhibits reversible adsorption for methanol. - Highlights: • Water-soluble coordination polymer was constructed by lead propylenediaminetetraacetate. • Its MOF product has a unique (H{sub 2}O){sub 26} cluster. • The product exhibits reversible adsorption for methanol.

Experimental Treatment of Bladder Cancer with Bi-213-anti-EGFR MAb

International Nuclear Information System (INIS)

Seidl, Christof; Pfost, Birgit; Müller, Felix

2013-01-01

Therapy of non-muscle-invasive bladder cancer (carcinoma in situ) comprises transurethral resection of the tumour and subsequent instillation of the chemotherapeutic drug mitomycin C in order to eradicate remaining tumour cells. Yet 15 – 40% of treated patients relapse within 5 years. Therefore, new therapeutic strategies to combat tumour recurrence are needed. Alpha-particle emitting radionuclides efficiently kill single tumour cells or small tumour cell clusters. Because the epidermal growth factor receptor (EGFR) is overexpressed on bladder cancer cells, conjugates composed of the alpha-emitter Bi-213 and the anti-EGFR antibody matuzumab should provide a powerful drug to eliminate disseminated bladder cancer cells. Therefore, the aims of our study were (i) to analyse the cytotoxic effects of Bi-213-anti-EGFR radioimmunoconjugates at the cellular level, (ii) to evaluate therapeutic efficacy of intravesically applied Bi-213- anti-EGFR-Mab in a nude mouse model with intravesical human bladder cancer xenografts, (iii) to compare Bi- 213-anti-EGFR-Mab efficacy with chemotherapy using mitomycin C and (iv) to demonstrate that radioimmunotherapy is not toxic to cells of the bladder wall and of the kidneys

7 CFR 1220.213 - Establishment and membership.

Science.gov (United States)

2010-01-01

....213 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... of the Secretary, a Soybean Program Coordinating Committee to assist in the administration of this... soybean production. (c) Cooperator Organization representation on the Committee shall consist of five...

25 CFR 213.6 - Leases for minerals other than oil and gas.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Leases for minerals other than oil and gas. 213.6 Section 213.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF... Leases for minerals other than oil and gas. Uncontested mining leases for minerals other than oil and gas...

Challenges in pKa Predictions for Proteins: The case of Asp213 in Human Proteinase 3

Science.gov (United States)

Hajjar, Eric; Dejaegere, Annick; Reuter, Nathalie

2009-09-01

Knowledge of the protonation states of the ionizable residues in an enzyme is a prerequisite to an accurate description of its structure and mechanism. In practice, the use of the inappropriate protonation state for an amino acid in a molecular modeling computation (e.g., molecular dynamics simulation) is likely to lead to unrealistic results. Although methods using solvers of the linearized Poisson-Boltzmann equation have proven to yield accurate pKa predictions, they bear a number of limitations. They are quite demanding in terms of computational power and are sensitive to representation of the charges and their position (force field and protein conformation). Moreover they depend on the choice of a dielectric constant for the protein interior. In this manuscript, we describe the difficulties met when trying to predict the protonation state of a buried amino acid, located in a protein for which very little biochemical data is available. Such a case is highly representative of the challenges faced in theoretical biology studies. Proteinase 3 (PR3) is an enzyme involved in proteolytic events associated with inflammation. It is a potential target in the development of new anti-inflammatory therapeutic strategies. We report the results of pKa predictions of the aspartic acid 213 of PR3 with a FDPB solver. We probed the influence of the choice of the dielectric constant for the protein interior ɛp and the benefits of conformational sampling by molecular dynamics (MD) on the pKa prediction of this carboxylate group. Using only the FDPB calculations, we could not conclude on the protonation state of Asp213. MD simulations confronted to knowledge of the ligand-binding and reaction mechanism led us to decide on a protonated form of this aspartic acid. We also demonstrate that the use of the wrong protonation state leads to an unreliable structural model for PR3. pKa prediction with a fast empirical method yielded a pKa of 8.4 for Asp213, which is in agreement with our

48 CFR 12.213 - Other commercial practices.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Other commercial practices... ACQUISITION PLANNING ACQUISITION OF COMMERCIAL ITEMS Special Requirements for the Acquisition of Commercial Items 12.213 Other commercial practices. It is a common practice in the commercial marketplace for both...

24 CFR 213.266 - Initial insurance endorsement.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Initial insurance endorsement. 213... insurance endorsement. The Commissioner shall indicate his insurance of the mortgage or supplementary loan by endorsing the original credit instrument and identifying the section of the Act and the...

41 CFR 101-29.213 - Commercial product.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Commercial product. 101... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 29-FEDERAL PRODUCT DESCRIPTIONS 29.2-Definitions § 101-29.213 Commercial product. A commercial product is any item, component, or...

24 CFR 213.268 - Final insurance endorsement.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Final insurance endorsement. 213... insurance endorsement. When all advances of mortgage or loan proceeds have been made and all the terms and... indicate on the original credit instrument the total of all advances he has approved for insurance and...

177Lu-immunotherapy of experimental peritoneal carcinomatosis shows comparable effectiveness to 213Bi-immunotherapy, but causes toxicity not observed with 213Bi

International Nuclear Information System (INIS)

Seidl, Christof; Zoeckler, Christine; Beck, Roswitha; Senekowitsch-Schmidtke, Reingard; Quintanilla-Martinez, Leticia; Bruchertseifer, Frank

2011-01-01

213 Bi-d9MAb-immunoconjugates targeting gastric cancer cells have effectively cured peritoneal carcinomatosis in a nude mouse model following intraperitoneal injection. Because the β-emitter 177 Lu has proven to be beneficial in targeted therapy, 177 Lu-d9MAb was investigated in this study in order to compare its therapeutic efficacy and toxicity with those of 213 Bi-d9MAb. Nude mice were inoculated intraperitoneally with HSC45-M2 gastric cancer cells expressing d9-E-cadherin and were treated intraperitoneally 1 or 8 days later with different activities of specific 177 Lu-d9MAb immunoconjugates targeting d9-E-cadherin or with nonspecific 177 Lu-d8MAb. Therapeutic efficacy was evaluated by monitoring survival for up to 250 days. For evaluation of toxicity, both biodistribution of 177 Lu-d9MAb and blood cell counts were determined at different time points and organs were examined histopathologically. Treatment with 177 Lu-immunoconjugates (1.85, 7.4, 14.8 MBq) significantly prolonged survival. As expected, treatment on day 1 after tumour cell inoculation was more effective than treatment on day 8, and specific 177 Lu-d9MAb conjugates were superior to nonspecific 177 Lu-d8MAb. Treatment with 7.4 MBq of 177 Lu-d9MAb was most successful, with 90% of the animals surviving longer than 250 days. However, treatment with therapeutically effective activities of 177 Lu-d9MAb was not free of toxic side effects. In some animals lymphoblastic lymphoma, proliferative glomerulonephritis and hepatocarcinoma were seen but were not observed after treatment with 213 Bi-d9MAb at comparable therapeutic efficacy. The therapeutic efficacy of 177 Lu-d9MAb conjugates in peritoneal carcinomatosis is impaired by toxic side effects. Because previous therapy with 213 Bi-d9MAb revealed comparable therapeutic efficacy without toxicity it should be preferred for the treatment of peritoneal carcinomatosis. (orig.)

47 CFR 25.213 - Inter-Service coordination requirements for the 1.6/2.4 GHz mobile-satellite service.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Inter-Service coordination requirements for the 1.6/2.4 GHz mobile-satellite service. 25.213 Section 25.213 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25.213 Inter...

The Role of RNF213 4810G>A and 4950G>A Variants in Patients with Moyamoya Disease in Korea

Directory of Open Access Journals (Sweden)

Young Seok Park

2017-11-01

Full Text Available Although a founder variant of RNF213 4810G>A is a major genetic risk factor for moyamoya disease (MMD in East Asians, the frequency and disease susceptibility of RNF213 variants remain largely unknown. This study investigated the mutation analysis of RNF213 (4448, 4810, 4863, and 4950 between Korean MMD and healthy controls. We performed a polymerase chain reaction-restriction fragment length polymorphism analysis. To identify the association between RNF213 gene polymorphisms and MMD disease, we performed statistical analyses such as multivariable logistic regression and Fisher’s exact test. Genetic data from 117 MMD patients were analyzed and compared with 253 healthy controls. We assessed and compared single nucleotide polymorphisms of RNF213 (4448, 4810, 4863, and 4950 between MMD and control groups. We performed genome-wide association studies to investigate the genetic pathophysiology of MMD. Among the RNF213 variants (4448G>A, 4810G>A, 4863G>A, and 4950G>A, RNF213 4810G>A and 4950G>A variants were more frequent in MMD patients. In a subgroup analysis, the RNF213 4810G>A was more frequent in moyamoya disease, and the comparison with GG+AA genotype was also significantly different in moyamoya patients. These results confirm that RNF213 4810G>A and RNF213 4950G>A were more frequent in MMD patients. We have confirmed that RNF213 4810G>A and 4950G>A are strongly associated with Korean MMD in children and adults as well as for the ischemic and hemorrhagic types.

ACHP | Advisory Council on Historic Preservation Section 213 Reports

Science.gov (United States)

Building, Washington, DC. Click here to read the Section 213 Report on the Highwood Generating Station , DC. For more information on the Section 106 process click here. Updated February 28, 2016 Return to

9 CFR 113.213 - Pseudorabies Vaccine, Killed Virus.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Pseudorabies Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.213 Pseudorabies Vaccine, Killed Virus. Pseudorabies Vaccine, Killed...

50 CFR 216.213 - Permissible methods of taking.

Science.gov (United States)

2010-10-01

... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking of Marine Mammals Incidental to Explosive Severance Activities Conducted During Offshore Structure Removal Operations on the Outer Continental Shelf in the U.S. Gulf of Mexico § 216.213 Permissible...

24 CFR 213.256 - Premiums; insurance upon completion.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Premiums; insurance upon completion... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES COOPERATIVE HOUSING MORTGAGE INSURANCE Contract Rights and Obligations-Projects § 213.256 Premiums...

ASTEC applications to VVER-440/V213 reactors

Energy Technology Data Exchange (ETDEWEB)

Matejovic, Peter, E-mail: ivstt@nextra.sk; Barnak, Miroslav; Bachraty, Milan; Vranka, Lubomir

2014-06-01

Since the beginning of ASTEC development by IRSN and GRS the code was widely applied to VVER reactors. In this paper, at first specific features of VVER-440/V213 reactor design that are important from the modelling point of view are briefly described. Then the validation of ASTEC code with focus on its applicability to VVER reactors is briefly summarised and the results obtained with the ASTEC V2.0-rev1 version for the ISP-33 PACTEL natural circulation experiment are presented. In the next section the application of ASTEC V2.0-rev1 code in upgrade of VVER-440/V213 NPPs to cope with consequences of severe accidents is described. This upgrade includes adoption of in-vessel retention via external reactor vessel cooling and installation of large capacity passive autocatalytic recombiners. Results of analysis with focus on corium localisation and stabilisation inside reactor vessel, hydrogen control in confinement and prevention of long-term confinement pressurisation are presented.

Alpha radioisotopes Ac-225 and Bi-213: a production and labelling of antibodies and peptides for clinical use

Energy Technology Data Exchange (ETDEWEB)

Bruchertseifer, Frank, E-mail: frank.bruchertseifer@ec.europa.eu [European Commission, Joint Research Centre, Karlsruhe (Germany)

2017-07-01

Full text: In various preclinical and clinical works the potential of the alpha emitters {sup 225}Ac and {sup 213}Bi as therapeutic radionuclides for application in targeted alpha therapy of cancer and infectious diseases was demonstrated. Both alpha emitters are available with high specific activity from established radionuclide generators. Their favorable chemical and physical properties have led to the conduction of a large number of preclinical studies and several clinical trials, demonstrating the feasibility, safety and therapeutic efficacy of targeted alpha therapy with {sup 225}Ac and {sup 213}Bi. This presentation will give an overview about the methods for the production of {sup 225}Ac and {sup 213}Bi, the {sup 225}Ac/{sup 213}Bi radionuclide generator systems, labelling of peptides and antibodies with {sup 225}Ac and {sup 213}Bi and relevant in vivo and in vitro works. (author)

47 CFR 73.213 - Grandfathered short-spaced stations.

Science.gov (United States)

2010-10-01

... Section 73.213 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES... showing is provided pursuant to paragraph (a)(2) of this section that demonstrates that the public interest would be served by the proposed changes. (1) The F(50,50) curves in Figure 1 of § 73.333 are to be...

The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality

Energy Technology Data Exchange (ETDEWEB)

Hitomi, Toshiaki [Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Habu, Toshiyuki [Radiation Biology Center, Kyoto University, Kyoto (Japan); Kobayashi, Hatasu; Okuda, Hiroko; Harada, Kouji H. [Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Osafune, Kenji [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Taura, Daisuke; Sone, Masakatsu [Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Asaka, Isao; Ameku, Tomonaga; Watanabe, Akira; Kasahara, Tomoko; Sudo, Tomomi; Shiota, Fumihiko [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Hashikata, Hirokuni; Takagi, Yasushi [Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Morito, Daisuke [Faculty of Life Sciences, Kyoto Sangyo University, Kyoto (Japan); Miyamoto, Susumu [Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Nakao, Kazuwa [Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Koizumi, Akio, E-mail: koizumi.akio.5v@kyoto-u.ac.jp [Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto (Japan)

2013-10-04

Highlights: •Overexpression of RNF213 R4810K inhibited cell proliferation. •Overexpression of RNF213 R4810K had the time of mitosis 4-fold and mitotic failure. •R4810K formed a complex with MAD2 more readily than wild-type. •iPSECs from the MMD patients had elevated mitotic failure compared from the control. •RNF213 R4810K induced mitotic abnormality and increased risk of aneuploidy. -- Abstract: Moyamoya disease (MMD) is a cerebrovascular disease characterized by occlusive lesions in the Circle of Willis. The RNF213 R4810K polymorphism increases susceptibility to MMD. In the present study, we characterized phenotypes caused by overexpression of RNF213 wild type and R4810K variant in the cell cycle to investigate the mechanism of proliferation inhibition. Overexpression of RNF213 R4810K in HeLa cells inhibited cell proliferation and extended the time of mitosis 4-fold. Ablation of spindle checkpoint by depletion of mitotic arrest deficiency 2 (MAD2) did not shorten the time of mitosis. Mitotic morphology in HeLa cells revealed that MAD2 colocalized with RNF213 R4810K. Immunoprecipitation revealed an RNF213/MAD2 complex: R4810K formed a complex with MAD2 more readily than RNF213 wild-type. Desynchronized localization of MAD2 was observed more frequently during mitosis in fibroblasts from patients (n = 3, 61.0 ± 8.2%) compared with wild-type subjects (n = 6, 13.1 ± 7.7%; p < 0.01). Aneuploidy was observed more frequently in fibroblasts (p < 0.01) and induced pluripotent stem cells (iPSCs) (p < 0.03) from patients than from wild-type subjects. Vascular endothelial cells differentiated from iPSCs (iPSECs) of patients and an unaffected carrier had a longer time from prometaphase to metaphase than those from controls (p < 0.05). iPSECs from the patients and unaffected carrier had significantly increased mitotic failure rates compared with controls (p < 0.05). Thus, RNF213 R4810K induced mitotic abnormalities and increased risk of genomic instability.

The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality

International Nuclear Information System (INIS)

Hitomi, Toshiaki; Habu, Toshiyuki; Kobayashi, Hatasu; Okuda, Hiroko; Harada, Kouji H.; Osafune, Kenji; Taura, Daisuke; Sone, Masakatsu; Asaka, Isao; Ameku, Tomonaga; Watanabe, Akira; Kasahara, Tomoko; Sudo, Tomomi; Shiota, Fumihiko; Hashikata, Hirokuni; Takagi, Yasushi; Morito, Daisuke; Miyamoto, Susumu; Nakao, Kazuwa; Koizumi, Akio

2013-01-01

Highlights: •Overexpression of RNF213 R4810K inhibited cell proliferation. •Overexpression of RNF213 R4810K had the time of mitosis 4-fold and mitotic failure. •R4810K formed a complex with MAD2 more readily than wild-type. •iPSECs from the MMD patients had elevated mitotic failure compared from the control. •RNF213 R4810K induced mitotic abnormality and increased risk of aneuploidy. -- Abstract: Moyamoya disease (MMD) is a cerebrovascular disease characterized by occlusive lesions in the Circle of Willis. The RNF213 R4810K polymorphism increases susceptibility to MMD. In the present study, we characterized phenotypes caused by overexpression of RNF213 wild type and R4810K variant in the cell cycle to investigate the mechanism of proliferation inhibition. Overexpression of RNF213 R4810K in HeLa cells inhibited cell proliferation and extended the time of mitosis 4-fold. Ablation of spindle checkpoint by depletion of mitotic arrest deficiency 2 (MAD2) did not shorten the time of mitosis. Mitotic morphology in HeLa cells revealed that MAD2 colocalized with RNF213 R4810K. Immunoprecipitation revealed an RNF213/MAD2 complex: R4810K formed a complex with MAD2 more readily than RNF213 wild-type. Desynchronized localization of MAD2 was observed more frequently during mitosis in fibroblasts from patients (n = 3, 61.0 ± 8.2%) compared with wild-type subjects (n = 6, 13.1 ± 7.7%; p < 0.01). Aneuploidy was observed more frequently in fibroblasts (p < 0.01) and induced pluripotent stem cells (iPSCs) (p < 0.03) from patients than from wild-type subjects. Vascular endothelial cells differentiated from iPSCs (iPSECs) of patients and an unaffected carrier had a longer time from prometaphase to metaphase than those from controls (p < 0.05). iPSECs from the patients and unaffected carrier had significantly increased mitotic failure rates compared with controls (p < 0.05). Thus, RNF213 R4810K induced mitotic abnormalities and increased risk of genomic instability

Fragmentations of 40Ar at 213 MeV/nucleon

International Nuclear Information System (INIS)

Viyogi, Y.P.; Symons, T.J.M.; Doll, P.; Greiner, D.E.; Heckman, H.H.; Hendrie, D.L.; Lindstrom, P.J.; Mahoney, J.; Scott, D.K.; Van Bibber, K.; Westfall, G.D.; Wieman, H.; Crawford, H.J.; McParland, C.; Gelbke, C.K.

1979-01-01

Energy and isotope distributions were measured for peripheral reactions induced by 40 Ar at 213 MeV/nucleon. The data are consistent with the predictions of abrasion-ablation models. The influence of correlations in the nuclear ground state is discussed

12 CFR 213.9 - Relation to state laws.

Science.gov (United States)

2010-01-01

... interpretative responsibilities for the state consumer leasing law, may apply to the Board for a preemption determination. (b) Exemptions—(1) Application. A state may apply to the Board for an exemption from the... LEASING (REGULATION M) § 213.9 Relation to state laws. (a) Inconsistent state law. A state law that is...

27 CFR 24.213 - Heavy bodied blending wine.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Heavy bodied blending wine..., DEPARTMENT OF THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.213 Heavy bodied blending wine. Heavy bodied blending wine is wine made for blending purposes from grapes or other fruit without...

Spectroscopy of high spin states in sup(211,212,213)Fr

International Nuclear Information System (INIS)

Byrne, A.P.; Dracoulis, G.D.; Fahlander, C.; Hubel, H.; Poletti, A.R.; Stuchbery, A.E.; Gerl, J.; Davie, R.F.; Poletti, S.J.

1985-08-01

The level structures of 211 Fr, 212 Fr and 213 Fr have been observed to high spins, approx. 28(h/2π) (and excitation energies approx. 8 MeV) using a variety of gamma-ray spectroscopic techniques. The structure of these nuclides is discussed in terms of couplings of single particle states through empirical shell model calculations. Good agreement with experiment is obtained. In 212 Fr and 213 Fr core-excited configurations are required to explain the properties of the highest states. A number of long lived states were observed in each nucleus some of which decay by by enhanced E3 transitions. The E3 transition strengths are discussed

48 CFR 253.213-70 - Completion of DD Form 1155, Order for Supplies or Services.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Completion of DD Form 1155... Forms 253.213-70 Completion of DD Form 1155, Order for Supplies or Services. Follow the procedures at PGI 253.213-70 for completion of DD Form 1155. [71 FR 3413, Jan. 23, 2006] ...

Lysines 72, 80 and 213 and aspartic acid 210 of the Lactococcus lactis LacR repressor are involved in the response to the inducer tagatose-6-phosphate leading to induction of lac operon expression.

Science.gov (United States)

van Rooijen, R J; Dechering, K J; Niek, C; Wilmink, J; de Vos, W M

1993-02-01

Site-directed mutagenesis of the Lactococcus lactis lacR gene was performed to identify residues in the LacR repressor that are involved in the induction of lacABCDFEGX operon expression by tagatose-6-phosphate. A putative inducer binding domain located near the C-terminus was previously postulated based on homology studies with the Escherichia coli DeoR family of repressors, which all have a phosphorylated sugar as inducer. Residues within this domain and lysine residues that are charge conserved in the DeoR family were changed into alanine or arginine. The production of the LacR mutants K72A, K80A, K80R, D210A, K213A and K213R in the LacR-deficient L.lactis strain NZ3015 resulted in repressed phospho-beta-galactosidase (LacG) activities and decreased growth rates on lactose. Gel mobility shift assays showed that the complex between a DNA fragment carrying the lac operators and LacR mutants K72A, K80A, K213A and D210A did not dissociate in the presence of tagatose-6-phosphate, in contrast to wild type LacR. Other mutations (K62A/K63A, K72R, K73A, K73R, T212A, F214R, R216R and R216K) exhibited no gross effects on inducer response. The results strongly suggest that the lysines at positions 72, 80 and 213 and aspartic acid at position 210 are involved in the induction of lac operon expression by tagatose-6-phosphate.

48 CFR 1352.213-71 - Instructions for submitting quotations under the simplified acquisition threshold-non-commercial.

Science.gov (United States)

2010-10-01

... submitting quotations under the simplified acquisition threshold-non-commercial. 1352.213-71 Section 1352.213... quotations under the simplified acquisition threshold—non-commercial. As prescribed in 48 CFR 1313.302-1-70, insert the following provision: Instructions for Submitting Quotations Under the Simplified Acquisition...

2,1,3-Benzothiadiazole: Study of its structure, energetics and aromaticity

International Nuclear Information System (INIS)

Miranda, Margarida S.; Matos, M. Agostinha R.; Morais, Victor M.F.; Liebman, Joel F.

2012-01-01

Highlights: ► Enthalpies of formation of 2,1,3-benzothiadiazole were determined. ► The structure of 2,1,3-benzothiadiazole was obtained from DFT calculations. ► Calculations allowed estimation of enthalpy of formation in gas phase. ► The aromaticity was evaluated by analysis of NICS values. - Abstract: The present work reports an experimental study on the energetics of 2,1,3-benzothiadiazole and a computational study on its structure, energetics and aromaticity. In the experimental part the standard (p° = 0.1 MPa) massic energy of combustion, at T = 298.15 K, was measured by rotating bomb combustion calorimetry, in oxygen, and allowed the calculation of the respective standard molar enthalpy of formation, in the crystalline phase, at T = 298.15 K. The standard molar enthalpy of sublimation, at T = 298.15 K, was measured by high-temperature Calvet microcalorimetry. From the combination of data obtained by both techniques we were able to calculate the respective standard molar enthalpy of formation, in the gas phase, at T = 298.15 K: (276.6 ± 2.5) kJ · mol −1 . This thermochemical parameter was compared with estimates obtained from high level ab initio quantum chemical calculations using the G3(MP2)//B3LYP composite method and various appropriately chosen reactions. The molecular structure of 2,1,3-benzothiadiazole was obtained from DFT calculations with the B3LYP density functional and various basis sets: 6-31G(d), 6-311(d,p), 6-311+G(3df,2p), aug-ccpVTZ and aug-ccpVQZ and its aromaticity and that of some related molecules were evaluated by analysis of nucleus independent chemical shifts (NICS) values.

Tetrahydro-2,1,3-boraoxazines - a new group boron heterocyclics

International Nuclear Information System (INIS)

Piotrowska, H.; Serafin, B.; Urbanski, T.; Vasudeva, S.K.

1977-01-01

The synthesis of new group of compounds derivative of tetrahydro-2,1,3 boraoxazine(5) by condensation of aminoalcohols 3 with aryloboronic acids(4) was carried out. The properties of new compounds are presented. (B.C.)

Optimizing labelling conditions of 213Bi-DOTATATE for preclinical applications of peptide receptor targeted alpha therapy.

Science.gov (United States)

Chan, Ho Sze; de Blois, Erik; Konijnenberg, Mark W; Morgenstern, Alfred; Bruchertseifer, Frank; Norenberg, Jeffrey P; Verzijlbergen, Fred J; de Jong, Marion; Breeman, Wouter A P

2017-01-01

213 Bismuth ( 213 Bi, T 1/2 = 45.6 min) is one of the most frequently used α-emitters in cancer research. High specific activity radioligands are required for peptide receptor radionuclide therapy. The use of generators containing less than 222 MBq 225 Ac (actinium), due to limited availability and the high cost to produce large-scale 225 Ac/ 213 Bi generators, might complicate in vitro and in vivo applications though.Here we present optimized labelling conditions of a DOTA-peptide with an 225 Ac/ 213 Bi generator (< 222 MBq) for preclinical applications using DOTA-Tyr 3 -octreotate (DOTATATE), a somatostatin analogue. The following labelling conditions of DOTATATE with 213 Bi were investigated; peptide mass was varied from 1.7 to 7.0 nmol, concentration of TRIS buffer from 0.15 mol.L -1 to 0.34 mol.L -1 , and ascorbic acid from 0 to 71 mmol.L -1 in 800 μL. All reactions were performed at 95 °C for 5 min. After incubation, DTPA (50 nmol) was added to stop the labelling reaction. Besides optimizing the labelling conditions, incorporation yield was determined by ITLC-SG and radiochemical purity (RCP) was monitored by RP-HPLC up to 120 min after labelling. Dosimetry studies in the reaction vial were performed using Monte Carlo and in vitro clonogenic assay was performed with a rat pancreatic tumour cell line, CA20948. At least 3.5 nmol DOTATATE was required to obtain incorporation ≥ 99 % with 100 MBq 213 Bi (at optimized pH conditions, pH 8.3 with 0.15 mol.L -1 TRIS) in a reaction volume of 800 μL. The cumulative absorbed dose in the reaction vial was 230 Gy/100 MBq in 30 min. A minimal final concentration of 0.9 mmol.L -1 ascorbic acid was required for ~100 MBq (t = 0) to minimize radiation damage of DOTATATE. The osmolarity was decreased to 0.45 Osmol/L.Under optimized labelling conditions, 213 Bi-DOTATATE remained stable up to 2 h after labelling, RCP was ≥ 85 %. In vitro showed a negative correlation between ascorbic acid

Influence of tumour size on the efficacy of targeted alpha therapy with (213)Bi-[DOTA(0),Tyr(3)]-octreotate.

Science.gov (United States)

Chan, Ho Sze; Konijnenberg, Mark W; de Blois, Erik; Koelewijn, Stuart; Baum, Richard P; Morgenstern, Alfred; Bruchertseifer, Frank; Breeman, Wouter A; de Jong, Marion

2016-12-01

Targeted alpha therapy has been postulated to have great potential for the treatment of small clusters of tumour cells as well as small metastases. (213)Bismuth, an α-emitter with a half-life of 46 min, has shown to be effective in preclinical as well as in clinical applications. In this study, we evaluated whether (213)Bi-[DOTA(0), Tyr(3)]-octreotate ((213)Bi-DOTATATE), a (213)Bi-labelled somatostatin analogue with high affinity for somatostatin receptor subtype 2 (SSTR2), is suitable for the treatment of larger neuroendocrine tumours overexpressing SSTR2 in comparison to its effectiveness for smaller tumours. We performed a preclinical targeted radionuclide therapy study with (213)Bi-DOTATATE in animals bearing tumours of different sizes (50 and 200 mm(3)) using two tumour models: H69 (human small cell lung carcinoma) and CA20948 (rat pancreatic tumour). Pharmacokinetics was determined for calculation of dosimetry in organs and tumours. H69- or CA20948-xenografted mice with tumour volumes of approximately 120 mm(3) were euthanized at 10, 30, 60 and 120 min post injection of a single dose of (213)Bi-DOTATATE (1.5-4.8 MBq). To investigate the therapeutic efficacy of (213)Bi-DOTATATE, xenografted H69 and CA20948 tumour-bearing mice with tumour sizes of 50 and 200 mm(3) were administered daily with a therapeutic dose of (213)Bi-DOTATATE (0.3 nmol, 2-4 MBq) for three consecutive days. The animals were followed for 90 days after treatment. At day 90, mice were injected with 25 MBq (99m)Tc-DMSA and imaged by SPECT/CT to investigate possible renal dysfunction due to (213)Bi-DOTATATE treatment. Higher tumour uptakes were found in CA20948 tumour-bearing animals compared to those in H69 tumour-bearing mice with the highest tumour uptake of 19.6 ± 6.6 %IA/g in CA20948 tumour-bearing animals, while for H69 tumour-bearing mice, the highest tumour uptake was found to be 9.8 ± 2.4 %IA/g. Nevertheless, as the anti-tumour effect was more pronounced in H69

49 CFR 213.353 - Turnouts, crossovers, and lift rail assemblies or other transition devices on moveable bridges.

Science.gov (United States)

2010-10-01

... other transition devices on moveable bridges. 213.353 Section 213.353 Transportation Other Regulations... rail assemblies or other transition devices on moveable bridges. (a) In turnouts and track crossings... other transition devices on moveable bridges, the track owner shall prepare an inspection and...

48 CFR 536.213-371 - Bids that include options.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Bids that include options... Contracting for Construction 536.213-371 Bids that include options. (a) Subject to the limitations in paragraph (c) of this section, you may include options in contracts if it is in the Government's interest...

49 CFR 213.59 - Elevation of curved track; runoff.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Elevation of curved track; runoff. 213.59 Section... track; runoff. (a) If a curve is elevated, the full elevation shall be provided throughout the curve, unless physical conditions do not permit. If elevation runoff occurs in a curve, the actual minimum...

The application of pulse shape discrimination in NE 213 to neutron spectrometry

International Nuclear Information System (INIS)

Perkins, L.J.; Scott, M.C.

1979-01-01

The use of a zero-crossing pulse shape discrimination technique to distinguish protons from alpha particles in NE 213 is described, and a theoretical analysis is performed to predict the zero crossing characteristics. It is shown that, irrespective of the particular method of pulse shape discrimination employed, the pulse shape at low energies no longer uniquely determines the particle type for electrons, protons, alpha particles or 12 C nuclei, and the general limitations of pulse shape discrimination in NE 213 are deduced. The use of an alpha discrimination technique is then discribed, enabling neutron spectra to be unfolded from the measured detector response using a differential code. (orig.)

Bismuth 213-labeled anti-CD45 radioimmunoconjugate to condition dogs for nonmyeloablative allogeneic marrow grafts

Energy Technology Data Exchange (ETDEWEB)

Sandmaier, B M.(Fred Hutchinson Cancer Research Center, Seattle, WA); Bethge, W A.(Fred Hutchinson Cancer Research Center, Seattle, WA); Wilbur, D. Scott (Washington, Univ Of); Hamlin, Donald K.(Washington, Univ Of); Santos, E B.(Fred Hutchinson Cancer Research Center, Seattle, WA); Brechbiel, M W.(National Cancer Institute, National Institutes of Health, Bethesda, MD); Fisher, Darrell R.(BATTELLE (PACIFIC NW LAB)); Storb, R. (Fred Hutchinson Cancer Research Center)

2002-01-01

To lower treatment-related mortality and toxicity of conventional marrow transplantation, a nonmyeloablative regimen using 200 cGy total-body irradiation (TBI) and mycophenolate mofetil (MMF) combined with cyclosporine (CSP) for postgrafting immunosuppression was developed. To circumvent possible toxic effects of external- beam gamma irradiation, strategies for targeted radiation therapy were investigated. We tested whether the short-lived (46 minutes) alpha-emitter Bi-213 conjugated to an anti-CD45 monoclonal antibody (mAb) could replace 200 cGy TBI and selectively target hematopoietic tissues in a canine model of nonmyeloablative DLA-identical marrow transplantation. Biodistribution studies using iodine 123-labeled anti-CD45 mAb showed uptake in blood, marrow, lymph nodes, spleen, and liver. In a dose-escalation study, 7 dogs treated with the Bi-213-anti-CD45 conjugate (Bi-213 dose, 0.1-5.9 mCi/kg[3.7-218 MBq/kg]) without marrow grafts had no toxic effects other than a mild, reversible suppression of blood counts. On the basis of these studies, 3 dogs were treated with 0.5 mg/kg Bi-213-labeled anti-CD45 mAb (Bi-213 doses, 3.6, 4.6, and 8.8 mCi/kg[133, 170, and 326 MBq/kg]) given in 6 injections 3 and 2 days before grafting of marrow from DLA-identical littermates. The dogs also received MMF (10 mg/kg subcutaneously twice daily the day of transplantation until day 27 afterward) and CSP (15 mg/kg orally twice daily the day before transplantation until 35 days afterward). Therapy was well tolerated except for transient elevations in levels of transaminases in 3 dogs, followed by, in one dog, ascites. All dogs achieved prompt engraftment and stable mixed hematopoietic chimerism, with donor contributions ranging from 30% to 70% after more than 27 weeks of follow-up. These results form the basis for additional studies in animals and the design of clinical trials using Bi-213 as a nonmyeloablative conditioning regimen with minimal toxicity.

Volumetric spiral chemical shift imaging of hyperpolarized [2-(13) c]pyruvate in a rat c6 glioma model.

Science.gov (United States)

Park, Jae Mo; Josan, Sonal; Jang, Taichang; Merchant, Milton; Watkins, Ron; Hurd, Ralph E; Recht, Lawrence D; Mayer, Dirk; Spielman, Daniel M

2016-03-01

MRS of hyperpolarized [2-(13)C]pyruvate can be used to assess multiple metabolic pathways within mitochondria as the (13)C label is not lost with the conversion of pyruvate to acetyl-CoA. This study presents the first MR spectroscopic imaging of hyperpolarized [2-(13)C]pyruvate in glioma-bearing brain. Spiral chemical shift imaging with spectrally undersampling scheme (1042 Hz) and a hard-pulse excitation was exploited to simultaneously image [2-(13)C]pyruvate, [2-(13)C]lactate, and [5-(13)C]glutamate, the metabolites known to be produced in brain after an injection of hyperpolarized [2-(13)C]pyruvate, without chemical shift displacement artifacts. A separate undersampling scheme (890 Hz) was also used to image [1-(13)C]acetyl-carnitine. Healthy and C6 glioma-implanted rat brains were imaged at baseline and after dichloroacetate administration, a drug that modulates pyruvate dehydrogenase kinase activity. The baseline metabolite maps showed higher lactate and lower glutamate in tumor as compared to normal-appearing brain. Dichloroacetate led to an increase in glutamate in both tumor and normal-appearing brain. Dichloroacetate-induced %-decrease of lactate/glutamate was comparable to the lactate/bicarbonate decrease from hyperpolarized [1-(13)C]pyruvate studies. Acetyl-carnitine was observed in the muscle/fat tissue surrounding the brain. Robust volumetric imaging with hyperpolarized [2-(13)C]pyruvate and downstream products was performed in glioma-bearing rat brains, demonstrating changes in mitochondrial metabolism with dichloroacetate. © 2015 Wiley Periodicals, Inc.

5-Methylbenzo[d][2,1,3]selenadiazole

Directory of Open Access Journals (Sweden)

Halima Ouahine

2017-02-01

Full Text Available In the crystal of the title compound, C7H6N2Se, the molecules are arranged in rods along the b-axis direction and form dimeric units due to intermolecular Se...N contacts of 2.982 (2 Å. The molecules are further linked by weak π–π stacking interactions between the 2,1,3-selenadiazole and six-membered aromatic rings [centroid–centroid distance = 3.8509 (11 Å and ring slippage = 1.539 (3 Å].

5 CFR 179.213 - Coordinating salary offset with other agencies.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Coordinating salary offset with other... REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.213 Coordinating salary offset with other agencies... intent of this regulation. (2) The designated salary offset coordinator will be responsible for: (i...

Calibration of a NE213 detector for neutron spectroscopy; Calibracion de un detector de NE213 para espectroscopia de neutrones

Energy Technology Data Exchange (ETDEWEB)

Blazquez Martinez, J; Butragueno Casado, J L

1974-07-01

This work describes the experimental way followed for getting the calibration of a NE213 detector with a beam of neutrons from the J.E.N. 2 MeV Van de Graaff and using at once pulse shape discrimination. Detector has been used for measuring the spectrum of the fast reactor CORAL-1. There is also included an experimental method in order to get with precision where the Compton edge is placed on the electron spectrum. (Author) 9 refs.

Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death

International Nuclear Information System (INIS)

Seidl, Christof; Schroeck, Hedwig; Seidenschwang, Sabine; Beck, Roswitha; Schwaiger, Markus; Senekowitsch-Schmidtke, Reingard; Schmid, Ernst; Abend, Michael; Becker, Karl-Friedrich; Apostolidis, Christos; Nikula, Tuomo K.; Kremmer, Elisabeth

2005-01-01

Radioimmunotherapy with α-particle-emitting nuclides, such as 213 Bi, is a promising concept for the elimination of small tumour nodules or single disseminated tumour cells. The aim of this study was to investigate cellular damage and the mode of cell death triggered by 213 Bi-immunoconjugates. Human gastric cancer cells (HSC45-M2) expressing d9-E-cadherin were incubated with different levels of activity of 213 Bi-d9MAb targeting d9-E-cadherin and 213 Bi-d8MAb, which does not bind to d9-E-cadherin. Micronucleated (M) cells, abnormal (A) cells and apoptotic (A) [(MAA)] cells were scored microscopically in the MAA assay following fluorescent staining of nuclei and cytoplasm. Chromosomal aberrations were analysed microscopically following Giemsa staining. The effect of z-VAD-fmk, known to inhibit apoptosis, on the prevention of cell death was investigated following treatment of HSC45-M2 cells with sorbitol as well as 213 Bi-d9MAb. Activation of caspase 3 after incubation of HSC45-M2 cells with both sorbitol and 213 Bi-d9MAb was analysed via Western blotting. Following incubation of HSC45-M2 human gastric cancer cells expressing d9-E-cadherin with 213 Bi-d9MAb the number of cells killed increased proportional to the applied activity concentration. Microscopically visible effects of α-irradiation of HSC45-M2 cells were formation of micronuclei and severe chromosomal aberrations. Preferential induction of these lesions with specific 213 Bi-d9MAb compared with unspecific 213 Bi-d8MAb (not targeting d9-E-cadherin) was not observed if the number of floating, i.e. unbound 213 Bi-immunoconjugates per cell exceeded 2 x 10 4 , most likely due to intense crossfire. In contrast to sorbitol-induced cell death, cell death triggered by 213 Bi-immunoconjugates was independent of caspase 3 activation and could not be inhibited by z-VAD-fmk, known to suppress the apoptotic pathway. 213 Bi-immunoconjugates seem to induce a mode of cell death different from apoptosis in HSC45-M2 cells

49 CFR 213.235 - Inspection of switches, track crossings, and lift rail assemblies or other transition devices on...

Science.gov (United States)

2010-10-01

... rail assemblies or other transition devices on moveable bridges. 213.235 Section 213.235 Transportation... assemblies or other transition devices on moveable bridges. (a) Except as provided in paragraph (c) of this section, each switch, turnout, track crossing, and moveable bridge lift rail assembly or other transition...

Relap5/Mod3.1 analysis of main steam header rupture in VVER- 440/213 NPP

Energy Technology Data Exchange (ETDEWEB)

Kral, P. [Nuclear Research Inst. Rez (Switzerland)

1995-12-31

The presentation is focused on two main topics. First the applied modelling of PGV-4 steam generator for RELAP5 code are described. The results of steady-state calculation under reference conditions are compared against measured data. The problem of longitudinal subdivision of SG tubes is analysed and evaluated. Secondly, a best-estimate analysis of main steam header (MSH) rupture accident in WWER-440/213 NPP is presented. The low reliability of initiation of ESFAS signal `MSH Rupture` leads in this accident to big loss of secondary coolant, full depressurization of main steam system, extremely fast cool-down of both secondary and primary system, opening of PRZ SV-bypass valve with later liquid outflow, potential reaching of secondary criticality by failure of HPIS. 7 refs.

Relap5/Mod3.1 analysis of main steam header rupture in VVER- 440/213 NPP

Energy Technology Data Exchange (ETDEWEB)

Kral, P [Nuclear Research Inst. Rez (Switzerland)

1996-12-31

The presentation is focused on two main topics. First the applied modelling of PGV-4 steam generator for RELAP5 code are described. The results of steady-state calculation under reference conditions are compared against measured data. The problem of longitudinal subdivision of SG tubes is analysed and evaluated. Secondly, a best-estimate analysis of main steam header (MSH) rupture accident in WWER-440/213 NPP is presented. The low reliability of initiation of ESFAS signal `MSH Rupture` leads in this accident to big loss of secondary coolant, full depressurization of main steam system, extremely fast cool-down of both secondary and primary system, opening of PRZ SV-bypass valve with later liquid outflow, potential reaching of secondary criticality by failure of HPIS. 7 refs.

Relap5/Mod3.1 analysis of main steam header rupture in VVER- 440/213 NPP

International Nuclear Information System (INIS)

Kral, P.

1995-01-01

The presentation is focused on two main topics. First the applied modelling of PGV-4 steam generator for RELAP5 code are described. The results of steady-state calculation under reference conditions are compared against measured data. The problem of longitudinal subdivision of SG tubes is analysed and evaluated. Secondly, a best-estimate analysis of main steam header (MSH) rupture accident in WWER-440/213 NPP is presented. The low reliability of initiation of ESFAS signal 'MSH Rupture' leads in this accident to big loss of secondary coolant, full depressurization of main steam system, extremely fast cool-down of both secondary and primary system, opening of PRZ SV-bypass valve with later liquid outflow, potential reaching of secondary criticality by failure of HPIS

Comparison of Americium-Beryllium neutron spectrum obtained using activation foil detectors and NE-213 spectrometer

International Nuclear Information System (INIS)

Sunny, Sunil; Subbaiah, K.V.; Selvakumaran, T.S.

1999-01-01

Neutron spectrum of Americium - Beryllium (α,n) source is measured with two different spectrometers vis-a-vis activation foils (foil detectors) and NE-213 organic scintillator. Activity induced in the foils is measured with 4π-β-γ sodium iodide detector by integrating counts under photo peak and the saturation activity is found by correcting to elapsed time before counting. The data on calculated activity is fed into the unfolding code, SAND-II to obtain neutron spectrum. In the case of organic scintillator, the pulse height spectrum is obtained using MCA and this is processed with unfolding code DUST in order to get neutron spectrum. The Americium - Beryllium (α,n) neutron spectrum thus obtained by two different methods is compared. It is inferred that the NE-213 scintillator spectrum is in excellent agreement with the values beyond 1MeV. Neutron spectrum obtained by activation foils depends on initial guess spectrum and is found to be in reasonable agreement with NE-213 spectrum. (author)

Therapy of Patients with Malignant Glioma with Targeted A-Radionuclide Therapy Using 213Bi-DOTA-[Thi8, Met (Oo)11]-Substanz P

International Nuclear Information System (INIS)

Forrer, F.; Mueller-Brand, J.; Cordier, D.; Merlo, A.; Morgenstern, A.; Bruchertseifer, F.; Maecke, H.R.

2009-01-01

The prognosis of patients with malignant glioma is very poor. New therapy options are mandatory. Substance P is the main ligand of neurokinin type 1 (NK-1) receptors, which are consistently over-expressed in malignant gliomas and surrounding tumor vessels. Administration of 90 Y-DOTA-[Thi 8 , Met (O o ) 11 ]-Substanz P was shown to be feasible and safe. However, in critically located tumors, the mean tissue range of 5 mm of 90 Y may lead to unacceptable damage of adjacent, functional critical areas of the brain. We report a phase I study with locally administered 213 Bi labeled DOTA-[Thi 8 , Met (O o ) 11 ]-Substanz P in patients with malignant glioma. By using a direct, intratumoral injection, the problem of the short physical half life of Bismuth-213 can be circumvent. To date, 5 patients with malignant glioma (2 Grade IV, 1 Grade III and 2 grade II) without previous treatment were included. One to three catheter systems were placed stereotactically into the tumor. After a diagnostic injection with 111 In-DOTA-[Thi 8 , Met (O o ) 11 ]-Substanz P and subsequent dosimetry, totally 30 to 138 mCi of 213 Bi-DOTA-[Thi8, Met (O o ) 11 ]-Substanz P was injected intratumorally performing 3 to 4 applications over 2 days. SPECT/CT was used to assess the biodistribution. Follow up was performed clinically and with morphological imaging. Targeted radiopeptide therapy using 213 Bi-DOTA-[Thi 8 , Met (O o ) 11 ]-Substanz P was very well tolerated by all patients. No additional neurological deficit was observed. Repetitive imaging is suggestive of progressive radiation-induced necrosis, which was validated by subsequent resection of the tumors. Time to progression was found to be 11 and 14 months respectively in patients with grade IV glioma. No progression is found after 18 to 23 months in patients with grade II or III glioma. We conclude that targeted loco-regional radiotherapy using 213 Bi-DOTA-[Thi 8 , Met (O o ) 11 ]-Substanz P represents an innovative and effective

Cell death triggered by alpha-emitting {sup 213}Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death

Energy Technology Data Exchange (ETDEWEB)

Seidl, Christof; Schroeck, Hedwig; Seidenschwang, Sabine; Beck, Roswitha; Schwaiger, Markus; Senekowitsch-Schmidtke, Reingard [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Schmid, Ernst [National Research Center for Environment and Health, Institute of Radiation Biology, GSF, Neuherberg (Germany); Abend, Michael [German Armed Forces, Institute of Radiobiology, Munich (Germany); Becker, Karl-Friedrich [Technische Universitaet Muenchen, Institute of Pathology, Munich (Germany); National Research Center for Environment and Health, Institute of Pathology, GSF, Neuherberg (Germany); National Research Center for Environment and Health, Institute of Molecular Immunology, GSF, Munich (Germany); Apostolidis, Christos; Nikula, Tuomo K. [European Commission, Institute for Transuranium Elements, Karlsruhe (Germany); Kremmer, Elisabeth [National Research Center for Environment and Health, Institute of Molecular Immunology, GSF, Munich (Germany)

2005-03-01

Radioimmunotherapy with {alpha}-particle-emitting nuclides, such as{sup 213}Bi, is a promising concept for the elimination of small tumour nodules or single disseminated tumour cells. The aim of this study was to investigate cellular damage and the mode of cell death triggered by {sup 213}Bi-immunoconjugates. Human gastric cancer cells (HSC45-M2) expressing d9-E-cadherin were incubated with different levels of activity of {sup 213}Bi-d9MAb targeting d9-E-cadherin and {sup 213}Bi-d8MAb, which does not bind to d9-E-cadherin. Micronucleated (M) cells, abnormal (A) cells and apoptotic (A) [(MAA)] cells were scored microscopically in the MAA assay following fluorescent staining of nuclei and cytoplasm. Chromosomal aberrations were analysed microscopically following Giemsa staining. The effect of z-VAD-fmk, known to inhibit apoptosis, on the prevention of cell death was investigated following treatment of HSC45-M2 cells with sorbitol as well as {sup 213}Bi-d9MAb. Activation of caspase 3 after incubation of HSC45-M2 cells with both sorbitol and {sup 213}Bi-d9MAb was analysed via Western blotting. Following incubation of HSC45-M2 human gastric cancer cells expressing d9-E-cadherin with {sup 213}Bi-d9MAb the number of cells killed increased proportional to the applied activity concentration. Microscopically visible effects of {alpha}-irradiation of HSC45-M2 cells were formation of micronuclei and severe chromosomal aberrations. Preferential induction of these lesions with specific {sup 213}Bi-d9MAb compared with unspecific {sup 213}Bi-d8MAb (not targeting d9-E-cadherin) was not observed if the number of floating, i.e. unbound {sup 213}Bi-immunoconjugates per cell exceeded 2 x 10{sup 4}, most likely due to intense crossfire. In contrast to sorbitol-induced cell death, cell death triggered by {sup 213}Bi-immunoconjugates was independent of caspase 3 activation and could not be inhibited by z-VAD-fmk, known to suppress the apoptotic pathway. {sup 213}Bi-immunoconjugates seem

25 CFR 213.34 - Inspection of premises; books and accounts.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of premises; books and accounts. 213.34... premises; books and accounts. Lessees shall agree to allow the lessors and their agents or any authorized... books and records, showing manner of operations and persons interested, shall be open at all times for...

Groundwater Monitoring Plan for the Reactor Technology Complex Operable Unit 2-13

International Nuclear Information System (INIS)

Richard P. Wells

2007-01-01

This Groundwater Monitoring Plan describes the objectives, activities, and assessments that will be performed to support the on-going groundwater monitoring requirements at the Reactor Technology Complex, formerly the Test Reactor Area (TRA). The requirements for groundwater monitoring were stipulated in the Final Record of Decision for Test Reactor Area, Operable Unit 2-13, signed in December 1997. The monitoring requirements were modified by the First Five-Year Review Report for the Test Reactor Area, Operable Unit 2-13, at the Idaho National Engineering and Environmental Laboratory to focus on those contaminants of concern that warrant continued surveillance, including chromium, tritium, strontium-90, and cobalt-60. Based upon recommendations provided in the Annual Groundwater Monitoring Status Report for 2006, the groundwater monitoring frequency was reduced to annually from twice a year

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 213, Revision 1 (FGE.213Rev1): Consideration of genotoxic potential for α , β -Unsaturated Alicyclic ketones and precursors from chemical subgroup

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Binderup, Mona-Lise; Lund, Pia

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 26 flavouring substances from subgroup 2.7 of FGE.19 in the Flavouring Group Evaluation 213. In the first version of FGE.213 the...

36 CFR 213.1 - Designation, administration, and development of National Grasslands.

Science.gov (United States)

2010-07-01

..., Power. Kansas Cimarron Morton, Stevens. Nebraska Oglala Dawes, Sioux. New Mexico Kiowa Colfax, Harding... TENANT ACT BY THE FOREST SERVICE § 213.1 Designation, administration, and development of National... Tenant Act. (c) The National Grasslands shall be administered under sound and progressive principles of...

Targeted alpha therapy of mCRPC. Dosimetry estimate of {sup 213}bismuth-PSMA-617

Energy Technology Data Exchange (ETDEWEB)

Kratochwil, Clemens; Afshar-Oromieh, Ali; Rathke, Hendrik; Giesel, Frederik L. [University Hospital Heidelberg, Department of Nuclear Medicine, Heidelberg (Germany); Schmidt, Karl [ABX-CRO, Dresden (Germany); Bruchertseifer, Frank; Morgenstern, Alfred [European Commission - Joint Research Centre, Directorate for Nuclear Safety and Security, Karlsruhe (Germany); Haberkorn, Uwe [University Hospital Heidelberg, Department of Nuclear Medicine, Heidelberg (Germany); German Cancer Research Center (DKFZ), Cooperation Unit Nuclear Medicine, Heidelberg (Germany)

2018-01-15

PSMA-617 is a small molecule targeting the prostate-specific membrane antigen (PSMA). In this work, we estimate the radiation dosimetry for this ligand labeled with the alpha-emitter {sup 213}Bi. Three patients with metastatic prostate cancer underwent PET scans 0.1 h, 1 h, 2 h, 3 h, 4 h and 5 h after injection of {sup 68}Ga-PSMA-617. Source organs were kidneys, liver, spleen, salivary glands, bladder, red marrow and representative tumor lesions. The imaging nuclide {sup 68}Ga was extrapolated to the half-life of {sup 213}Bi. The residence times of {sup 213}Bi were forwarded to the instable daughter nuclides. OLINDA was used for dosimetry calculation. Results are discussed in comparison to literature data for {sup 225}Ac-PSMA-617. Assuming a relative biological effectiveness of 5 for alpha radiation, the dosimetry estimate revealed equivalent doses of mean 8.1 Sv{sub RBE5}/GBq for salivary glands, 8.1 Sv{sub RBE5}/GBq for kidneys and 0.52 Sv{sub RBE5}/GBq for red marrow. Liver (1.2 Sv{sub RBE5}/GBq), spleen (1.4 Sv{sub RBE5}/GBq), bladder (0.28 Sv{sub RBE5}/GBq) and other organs (0.26 Sv{sub RBE5}/GBq) were not dose-limiting. The effective dose is 0.56 Sv{sub RBE5}/GBq. Tumor lesions were in the range 3.2-9.0 Sv{sub RBE5}/GBq (median 7.6 Sv{sub RBE5}/GBq). Kidneys would limit the cumulative treatment activity to 3.7 GBq; red marrow might limit the maximum single fraction to 2 GBq. Despite promising results, the therapeutic index was inferior compared to {sup 225}Ac-PSMA-617. Dosimetry of {sup 213}Bi-PSMA-617 is in a range traditionally considered reasonable for clinical application. Nevertheless, compared to {sup 225}Ac-PSMA-617, it suffers from higher perfusion-dependent off-target radiation and a longer biological half-life of PSMA-617 in dose-limiting organs than the physical half-life of {sup 213}Bi, rendering this nuclide as a second choice radiolabel for targeted alpha therapy of prostate cancer. (orig.)

The 2ν2 bands of H212CO and H213CO by high-resolution FTIR spectroscopy

Science.gov (United States)

Tan, T. L.; A'dawiah, Rabia'tul; Ng, L. L.

2017-10-01

The Fourier transform infrared (FTIR) absorption spectra of the 2ν2 overtone bands of formaldehyde H212CO and its isotopologue H213CO were recorded at an unapodized resolution of 0.0063 cm-1 in the 3300-3540 cm-1 region. Upper state (v2 = 2) rovibrational up to two sextic centrifugal distortion constants were accurately determined for both H212CO and H213CO. A total of 533 unperturbed infrared transitions of H212CO and 466 unperturbed infrared transitions of H212CO were assigned and fitted with rms deviations of 0.0012 cm-1 and 0.00084 cm-1 respectively using Watson's A-reduced Hamiltonian in the Ir representation. Analysis of new transitions for H212CO measured in this work yielded upper state constants with greater accuracy than previously reported. The infrared transitions of the 2ν2 band of H213CO were measured for the first time. The band center of the A-type 2ν2 band of H212CO was found to be 3471.71403 ± 0.00012 cm-1 and that of H213CO was 3396.628983 ± 0.000083 cm-1. Furthermore, the newly assigned high-resolution infrared lines of the 2ν2 bands in the 3300-3540 cm-1 region can be useful in detecting the H212CO and H213CO molecules in this IR region.

17DD and 17D-213/77 yellow fever substrains trigger a balanced cytokine profile in primary vaccinated children.

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Ana Carolina Campi-Azevedo

Full Text Available BACKGROUND: This study aimed to compare the cytokine-mediated immune response in children submitted to primary vaccination with the YF-17D-213/77 or YF-17DD yellow fever (YF substrains. METHODS: A non-probabilistic sample of eighty healthy primary vaccinated (PV children was selected on the basis of their previously known humoral immune response to the YF vaccines. The selected children were categorized according to their YF-neutralizing antibody titers (PRNT and referred to as seroconverters (PV-PRNT(+ or nonseroconverters (PV-PRNT(-. Following revaccination with the YF-17DD, the PV-PRNT(- children (YF-17D-213/77 and YF-17DD groups seroconverted and were referred as RV-PRNT(+. The cytokine-mediated immune response was investigated after short-term in vitro cultures of whole blood samples. The results are expressed as frequency of high cytokine producers, taking the global median of the cytokine index (YF-Ag/control as the cut-off. RESULTS: The YF-17D-213/77 and the YF-17DD substrains triggered a balanced overall inflammatory/regulatory cytokine pattern in PV-PRNT(+, with a slight predominance of IL-12 in YF-17DD vaccinees and a modest prevalence of IL-10 in YF-17D-213/77. Prominent frequency of neutrophil-derived TNF-α and neutrophils and monocyte-producing IL-12 were the major features of PV-PRNT(+ in the YF-17DD, whereas relevant inflammatory response, mediated by IL-12(+CD8(+ T cells, was the hallmark of the YF-17D-213/77 vaccinees. Both substrains were able to elicit particular but relevant inflammatory events, regardless of the anti-YF PRNT antibody levels. PV-PRNT(- children belonging to the YF-17DD arm presented gaps in the inflammatory cytokine signature, especially in terms of the innate immunity, whereas in the YF-17D-213/77 arm the most relevant gap was the deficiency of IL-12-producing CD8(+T cells. Revaccination with YF-17DD prompted a balanced cytokine profile in YF-17DD nonresponders and a robust inflammatory profile in YF-17D

Performance comparison of 2-1-3, 1-3 and 1-3-2 piezoelectric composite transducers by finite element method

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Y. Sun

2018-03-01

Full Text Available 1-3 type, 1-3-2 type and 2-1-3 type piezoelectric composites are three proper smart materials for the design and manufacture of ultrasonic transducers. They have been proposed in different stages but possess similar properties. Compared with the initial 1-3 type composite, 1-3-2 composite is of higher mechanical stability. Compared with 1-3-2 composite, 2-1-3 composite has lower manufacturing difficulty. In this paper, a comparative study on these three composites in terms of receiving transducer material properties is presented. Finite element method (FEM has been adopted to calculate longitudinal velocity, thickness electromechanical coupling coefficient and voltage receiving sensitivity. It is concluded that for a large aspect ratio α=1, the performance of 2-1-3 composite transducer is much better than that of 1-3 and 1-3-2 composite transducers. The thickness electromechanical coupling coefficient of 2-1-3 composite transducer is about 5.58 times that of 1-3 composite transducer and 7.42 times that of 1-3-2 composite transducer. The voltage receiving sensitivity at 2 kHz of 2-1-3 composite transducer is 13.1 dB higher than that of 1-3-2 composite transducer and 12.3 dB higher than that of 1-3 composite transducer.

miR-21-3p is a positive regulator of L1CAM in several human carcinomas.

Science.gov (United States)

Doberstein, Kai; Bretz, Niko P; Schirmer, Uwe; Fiegl, Heidi; Blaheta, Roman; Breunig, Christian; Müller-Holzner, Elisabeth; Reimer, Dan; Zeimet, Alain G; Altevogt, Peter

2014-11-28

Expression of L1 cell adhesion molecule (L1CAM) occurs frequently in human cancers and is associated with poor prognosis in cancers such as ovarian, endometrial, breast, renal cell carcinoma and pancreatic ductal adenocarcinoma. L1CAM promotes cell motility, invasion, chemoresistance and metastasis formation. Elucidating genetic processes involved in the expression of L1CAM in cancers is of considerable importance. Transcription factors such as SLUG, β-catenin/TCF-LEF, PAX8 and VHL have been implicated in the re-activation of L1CAM in various types of cancers. There is increasing evidence that micro-RNAs can also have strong effects on gene expression. Here we have identified miR-21-3p as a positive regulator of L1CAM expression. Over-expression of miR-21-3p (miR-21*) but not the complementary sequence miR-21-5p (miR-21) could strongly augment L1CAM expression in renal, endometrial and ovarian carcinoma derived cell lines by an unknown mechanism involving transcriptional activation of the L1CAM gene. In patient cohorts from renal, endometrial and ovarian cancers we observed a strong positive correlation of L1CAM and miR-21-3p expressions. Although L1CAM alone was a reliable marker for overall and disease free survival, the combination of L1CAM and miR-21-3p expressions strongly enhanced the predictive power. Our findings shed new light on the complex regulation of L1CAM in cancers and advocate the use of L1CAM/miR-21-3p for diagnostic application. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

5 CFR 532.213 - Industries included in regular appropriated fund wage surveys.

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2010-01-01

... food service and laundry establishments and industries having peculiar employment conditions that... CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.213 Industries... transportation except taxi and limousine service (NAICS 4853). 487 (except 4872) Scenic and sightseeing...

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.

Science.gov (United States)

Banh, Robert S; Iorio, Caterina; Marcotte, Richard; Xu, Yang; Cojocari, Dan; Rahman, Anas Abdel; Pawling, Judy; Zhang, Wei; Sinha, Ankit; Rose, Christopher M; Isasa, Marta; Zhang, Shuang; Wu, Ronald; Virtanen, Carl; Hitomi, Toshiaki; Habu, Toshiyuki; Sidhu, Sachdev S; Koizumi, Akio; Wilkins, Sarah E; Kislinger, Thomas; Gygi, Steven P; Schofield, Christopher J; Dennis, James W; Wouters, Bradly G; Neel, Benjamin G

2016-07-01

Tumours exist in a hypoxic microenvironment and must limit excessive oxygen consumption. Hypoxia-inducible factor (HIF) controls mitochondrial oxygen consumption, but how/if tumours regulate non-mitochondrial oxygen consumption (NMOC) is unknown. Protein-tyrosine phosphatase-1B (PTP1B) is required for Her2/Neu-driven breast cancer (BC) in mice, although the underlying mechanism and human relevance remain unclear. We found that PTP1B-deficient HER2(+) xenografts have increased hypoxia, necrosis and impaired growth. In vitro, PTP1B deficiency sensitizes HER2(+) BC lines to hypoxia by increasing NMOC by α-KG-dependent dioxygenases (α-KGDDs). The moyamoya disease gene product RNF213, an E3 ligase, is negatively regulated by PTP1B in HER2(+) BC cells. RNF213 knockdown reverses the effects of PTP1B deficiency on α-KGDDs, NMOC and hypoxia-induced death of HER2(+) BC cells, and partially restores tumorigenicity. We conclude that PTP1B acts via RNF213 to suppress α-KGDD activity and NMOC. This PTP1B/RNF213/α-KGDD pathway is critical for survival of HER2(+) BC, and possibly other malignancies, in the hypoxic tumour microenvironment.

Neuromuscular regulation in zebrafish by a large AAA+ ATPase/ubiquitin ligase, mysterin/RNF213

Science.gov (United States)

Kotani, Yuri; Morito, Daisuke; Yamazaki, Satoru; Ogino, Kazutoyo; Kawakami, Koichi; Takashima, Seiji; Hirata, Hiromi; Nagata, Kazuhiro

2015-01-01

Mysterin (also known as RNF213) is a huge intracellular protein with two AAA+ ATPase modules and a RING finger ubiquitin ligase domain. Mysterin was originally isolated as a significant risk factor for the cryptogenic cerebrovascular disorder moyamoya disease, and was found to be involved in physiological angiogenesis in zebrafish. However, the function and the physiological significance of mysterin in other than blood vessels remain largely unknown, although mysterin is ubiquitously expressed in animal tissues. In this study, we performed antisense-mediated suppression of a mysterin orthologue in zebrafish larvae and revealed that mysterin-deficient larvae showed significant reduction in fast myofibrils and immature projection of primary motoneurons, leading to severe motor deficits. Fast muscle-specific restoration of mysterin expression cancelled these phenotypes, and interestingly both AAA+ ATPase and ubiquitin ligase activities of mysterin were indispensable for proper fast muscle formation, demonstrating an essential role of mysterin and its enzymatic activities in the neuromuscular regulation in zebrafish. PMID:26530008

Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development.

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Wanyang Liu

Full Text Available Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its susceptibility locus has been mapped to 17q25.3 in Japanese families, but the susceptibility gene is unknown.Genome-wide linkage analysis in eight three-generation families with moyamoya disease revealed linkage to 17q25.3 (P<10(-4. Fine mapping demonstrated a 1.5-Mb disease locus bounded by D17S1806 and rs2280147. We conducted exome analysis of the eight index cases in these families, with results filtered through Ng criteria. There was a variant of p.N321S in PCMTD1 and p.R4810K in RNF213 in the 1.5-Mb locus of the eight index cases. The p.N321S variant in PCMTD1 could not be confirmed by the Sanger method. Sequencing RNF213 in 42 index cases confirmed p.R4810K and revealed it to be the only unregistered variant. Genotyping 39 SNPs around RNF213 revealed a founder haplotype transmitted in 42 families. Sequencing the 260-kb region covering the founder haplotype in one index case did not show any coding variants except p.R4810K. A case-control study demonstrated strong association of p.R4810K with moyamoya disease in East Asian populations (251 cases and 707 controls with an odds ratio of 111.8 (P = 10(-119. Sequencing of RNF213 in East Asian cases revealed additional novel variants: p.D4863N, p.E4950D, p.A5021V, p.D5160E, and p.E5176G. Among Caucasian cases, variants p.N3962D, p.D4013N, p.R4062Q and p.P4608S were identified. RNF213 encodes a 591-kDa cytosolic protein that possesses two functional domains: a Walker motif and a RING finger domain. These exhibit ATPase and ubiquitin ligase activities. Although the mutant alleles (p.R4810K or p.D4013N in the RING domain did not affect transcription levels or ubiquitination activity, knockdown of RNF213 in zebrafish caused irregular wall formation in trunk arteries and abnormal sprouting vessels.We provide evidence suggesting, for the first time, the involvement of RNF213 in genetic susceptibility to moyamoya

Assessment of computer codes for VVER-440/213-type nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

Szabados, L.; Ezsol, Gy.; Perneczky [Atomic Energy Research Institute, Budapest (Hungary)

1995-09-01

Nuclear power plant of VVER-440/213 designed by the former USSR have a number of special features. As a consequence of these features the transient behaviour of such a reactor system should be different from the PWR system behaviour. To study the transient behaviour of the Hungarian Paks Nuclear Power Plant of VVER-440/213-type both analytical and experimental activities have been performed. The experimental basis of the research in the PMK-2 integral-type test facility , which is a scaled down model of the plant. Experiments performed on this facility have been used to assess thermal-hydraulic system codes. Four tests were selected for {open_quotes}Standard Problem Exercises{close_quotes} of the International Atomic Energy Agency. Results of the 4th Exercise, of high international interest, are presented in the paper, focusing on the essential findings of the assessment of computer codes.

25 CFR 213.44 - Division of royalty to separate fee owners.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Division of royalty to separate fee owners. 213.44... Division of royalty to separate fee owners. Should the removal of restrictions affect only part of the acreage covered by a lease containing provisions to the effect that the royalties accruing under the lease...

CLASS B2108+213 : a new wide-separation gravitational lens system

NARCIS (Netherlands)

McKean, JP; Browne, IWA; Jackson, NJ; Koopmans, LVE; Norbury, MA; Treu, T; York, TD; Biggs, AD; Blandford, RD; de Bruyn, AG; Fassnacht, CD; Mao, S; Myers, ST; Pearson, TJ; Phillips, PM; Readhead, ACS; Rusin, D; Wilkinson, PN

2005-01-01

We present observations of CLASS B2108 + 213, the widest separation gravitational lens system discovered by the Cosmic Lens All-Sky Survey. Radio imaging using the VLA at 8.46 GHz and MERLIN at 5 GHz shows two compact components separated by 4.56 arcsec with a faint third component in between which

On timing response improvement of an NE213 scintillator attached to two PMTs

International Nuclear Information System (INIS)

Zare, S.; Ghal-Eh, N.; Bayat, E.

2013-01-01

A 5 cm diameter by 6 cm height NE213 scintillator attached to two XP2282 PHOTONIS photomultiplier tubes (PMTs) exposed to 241 Americium–Berylium (Am–Be) neutron–gamma source has been used for timing response studies. The neutron–gamma discrimination (NGD) measurements based on a modified zero-crossing (ZC) method show that the discrimination quality, usually expressed in figure-of-merit (FoM) and peak-to-valley (P/V) values, has been improved. The timing response evaluated with Monte Carlo light transport code, PHOTRACK, also verifies this improvement. - Highlights: • An NE213 scintillator attached to two photomultiplier tubes (PMTs) has been proposed. • The neutron–gamma discrimination (NGD) quality factors have been obtained. • The results confirm that the NGD quality of the proposed assembly has been improved

Calibration of a NE213 detector for neutron spectroscopy

International Nuclear Information System (INIS)

Blazquez Martinez, J.; Butragueno Casado, J. L.

1974-01-01

This work describes the experimental way followed for getting the calibration of a NE213 detector with a beam of neutrons from the J.E.N. 2 MeV Van de Graaff and using at once pulse shape discrimination. Detector has been used for measuring the spectrum of the fast reactor CORAL-1. There is also included an experimental method in order to get with precision where the Compton edge is placed on the electron spectrum. (Author) 9 refs

25 CFR 213.17 - Government reserves right to purchase minerals produced.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Government reserves right to purchase minerals produced... Leases § 213.17 Government reserves right to purchase minerals produced. In time of war or other public... prevailing market price on the date of sale all or any part of the minerals produced under any lease. Rents...

Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies

NARCIS (Netherlands)

A.B. Graves; C.M. van Duijn (Cornelia); V. Chandra; L. Fratiglioni (Laura); A. Heyman; A.F. Jorm; E. Kokmen (Emre); K. Kondo; J.A. Mortimer; W.A. Rocca; S.L. Shalat; H. Soininen; A. Hofman (Albert)

1991-01-01

textabstractA meta-analysis, involving the secondary analysis of original data from 11 case-control studies of Alzheimer's disease, is presented for occupational exposures to solvents and lead. Three studies had data on occupational exposure to solvents. Among cases, 21.3% were reported to have been

First results of Minimum Fisher Regularisation as unfolding method for JET NE213 liquid scintillator neutron spectrometry

International Nuclear Information System (INIS)

Mlynar, Jan; Adams, John M.; Bertalot, Luciano; Conroy, Sean

2005-01-01

At JET, the NE213 liquid scintillator is being validated as a diagnostic tool for spectral measurements of neutrons emitted from the plasma. Neutron spectra have to be unfolded from the measured pulse-height spectra, which is an ill-conditioned problem. Therefore, use of two independent unfolding methods allows for less ambiguity on the interpretation of the data. In parallel to the routine algorithm MAXED based on the Maximum Entropy method, the Minimum Fisher Regularisation (MFR) method has been introduced at JET. The MFR method, known from two-dimensional tomography applications, has proved to provide a new transparent tool to validate the JET neutron spectra measured with the NE213 liquid scintillators. In this article, the MFR method applicable to spectra unfolding is briefly explained. After a mention of MFR tests on phantom spectra experimental neutron spectra are presented that were obtained by applying MFR to NE213 data in selected JET experiments. The results tend to confirm MAXED observations

NE213/BC501A scintillator−lightguide assembly response to 241Am−Be neutrons: An MCNPX−PHOTRACK hybrid code simulation

International Nuclear Information System (INIS)

Tajik, M.; Ghal-Eh, N.; Etaati, G.R.; Afarideh, H.

2014-01-01

The response of an NE213 (or its BICRON equivalent, BC501A) scintillator attached to different sizes of polished/painted lightguides when exposed to 241 Am–Be neutrons has been simulated. This kind of simulation basically needs both particle and light transports: the transport of neutrons and neutron-induced charged particles such as alphas, protons, carbon nuclei and so on has been undertaken using MCNPX whilst the scintillation light transport has been performed with PHOTRACK codes. The comparison between simulated and experimental response functions of NE213 attached to different sizes of polished/painted lightguides and also the influence of length/covering of lightguide on the detection efficiency and uniformity of the scintillator–lightguide assembly response have been studied. - Highlights: • The response of NE213 scintillator with/without lightguides to Am–Be neutrons has been simulated. • The MCNPX–PHOTRACK code has been used for simulation studies in order to model radio-optical properties. • The measured and simulated spectra for an NE213 scintillator exposed to Am–Be source represent a good agreement

Digital karyotyping reveals probable target genes at 7q21.3 locus in hepatocellular carcinoma

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Wang Shengyue

2011-07-01

Full Text Available Abstract Background Hepatocellular carcinoma (HCC is a worldwide malignant liver tumor with high incidence in China. Subchromosomal amplifications and deletions accounted for major genomic alterations occurred in HCC. Digital karyotyping was an effective method for analyzing genome-wide chromosomal aberrations at high resolution. Methods A digital karyotyping library of HCC was constructed and 454 Genome Sequencer FLX System (Roche was applied in large scale sequencing of the library. Digital Karyotyping Data Viewer software was used to analyze genomic amplifications and deletions. Genomic amplifications of genes detected by digital karyotyping were examined by real-time quantitative PCR. The mRNA expression level of these genes in tumorous and paired nontumorous tissues was also detected by real-time quantitative RT-PCR. Results A total of 821,252 genomic tags were obtained from the digital karyotyping library of HCC, with 529,162 tags (64% mapped to unique loci of human genome. Multiple subchromosomal amplifications and deletions were detected through analyzing the digital karyotyping data, among which the amplification of 7q21.3 drew our special attention. Validation of genes harbored within amplicons at 7q21.3 locus revealed that genomic amplification of SGCE, PEG10, DYNC1I1 and SLC25A13 occurred in 11 (21%, 11 (21%, 11 (21% and 23 (44% of the 52 HCC samples respectively. Furthermore, the mRNA expression level of SGCE, PEG10 and DYNC1I1 were significantly up-regulated in tumorous liver tissues compared with corresponding nontumorous counterparts. Conclusions Our results indicated that subchromosomal region of 7q21.3 was amplified in HCC, and SGCE, PEG10 and DYNC1I1 were probable protooncogenes located within the 7q21.3 locus.

Production of a bacteriocin-like inhibitory substance by Leuconostoc mesenteroides subsp. dextranicum 213M0 isolated from Mongolian fermented mare milk, airag.

Science.gov (United States)

Arakawa, Kensuke; Yoshida, Saki; Aikawa, Hiroki; Hano, Chihiro; Bolormaa, Tsognemekh; Burenjargal, Sedkhuu; Miyamoto, Taku

2016-03-01

Strain 213M0 was selected with productivity of a bacteriocin-like inhibitory substance (BLIS) among 235 strains of lactic acid bacteria (LAB) isolated from Mongolian fermented milk 'airag'. Strain 213M0 was species-identified as Leuconostoc mesenteroides subsp. dextranicum by morphological observation, carbohydrate fermentation profiling and sequencing the 16S rRNA gene. Incubation temperature proper to produce the BLIS was 25°C rather than 30 and 37°C, and the production actively proceeded during the exponential growth phase of the producer cells. Antibacterial effect of BLIS 213M0 was limited to all nine strains of Listeria sp. bacteria and seven strains of LAB cocci among 53 tested strains, which corresponds to a typical feature of the class IIa pediocin-like bacteriocins. BLIS 213M0 was not inactivated in every broad pH range solution (pH 2.0-11.0), and was stable against storage at 25°C for 1 week and heating at 121°C for 15 min under pH 4.5. Peptide frame of BLIS 213M0 was confirmed by inactivation with some peptidases, and then its molecular weight was estimated to be 2.6-3.0 kDa using an in situ activity assay following sodium dodecyl sulfate polyacrylamide gel electrophoresis. The estimated size was different from the other Leuconostoc bacteriocins already reported. These results suggest that BLIS 213M0 would be a novel listericidal bacteriocin. © 2015 Japanese Society of Animal Science.

Enhanced efficacy of combined 213Bi-DTPA-F3 and paclitaxel therapy of peritoneal carcinomatosis is mediated by enhanced induction of apoptosis and G2/M phase arrest

International Nuclear Information System (INIS)

Vallon, Mario; Seidl, Christof; Blechert, Birgit; Li, Zhoulei; Gaertner, Florian C.; Senekowitsch-Schmidtke, Reingard; Essler, Markus; Gilbertz, Klaus-Peter; Baumgart, Anja; Aichler, Michaela; Feuchtinger, Annette; Walch, Axel K.; Bruchertseifer, Frank; Morgenstern, Alfred

2012-01-01

Targeted therapy with α-particle emitting radionuclides is a promising new option in cancer therapy. Stable conjugates of the vascular tumour-homing peptide F3 with the α-emitter 213 Bi specifically target tumour cells. The aim of our study was to determine efficacy of combined 213 Bi-diethylenetriaminepentaacetic acid (DTPA)-F3 and paclitaxel treatment compared to treatment with either 213 Bi-DTPA-F3 or paclitaxel both in vitro and in vivo. Cytotoxicity of treatment with 213 Bi-DTPA-F3 and paclitaxel, alone or in combination, was assayed towards OVCAR-3 cells using the alamarBlue assay, the clonogenic assay and flow cytometric analyses of the mode of cell death and cell cycle arrest. Therapeutic efficacy of the different treatment options was assayed after repeated treatment of mice bearing intraperitoneal OVCAR-3 xenograft tumours. Therapy monitoring was performed by bioluminescence imaging and histopathologic analysis. Treatment of OVCAR-3 cells in vitro with combined 213 Bi-DTPA-F3 and paclitaxel resulted in enhanced cytotoxicity, induction of apoptosis and G2/M phase arrest compared to treatment with either 213 Bi-DTPA-F3 or paclitaxel. Accordingly, i.p. xenograft OVCAR-3 tumours showed the best response following repeated (six times) combined therapy with 213 Bi-DTPA-F3 (1.85 MBq) and paclitaxel (120 μg) as demonstrated by bioluminescence imaging and histopathologic investigation of tumour spread on the mesentery of the small and large intestine. Moreover, mean survival of xenograft mice that received combined therapy with 213 Bi-DTPA-F3 and paclitaxel was significantly superior to mice treated with either 213 Bi-DTPA-F3 or paclitaxel alone. Combined treatment with 213 Bi-DTPA-F3 and paclitaxel significantly increased mean survival of mice with peritoneal carcinomatosis of ovarian origin, thus favouring future therapeutic application. (orig.)

22 CFR 213.22 - Salary offset when USAID is the creditor agency.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Salary offset when USAID is the creditor agency... Administrative Offset § 213.22 Salary offset when USAID is the creditor agency. (a) Due process requirements... through salary offset, USAID will first provide the employee with the opportunity to pay in full the...

Neutron spectrometry with the NE-213 organic scintillator detector

International Nuclear Information System (INIS)

Silva, A.A. da.

1980-12-01

A neutron spectrometer with the NE-213 organic scintillator detector (5,08cm x 5,08cm) was mounted, tested, and calibrated at the Argonaut Reactor Laboratory of the Instituto de Engenharia Nuclear, to measure and study spectra of available fast neutron sources. The time zero-crossover technique was employed to discriminate the pulse of neutrons and gammas. The neutron spectrum from a 241 Am-Be source was determined experimentally in the range 1,0 MeV to 12,0 MeV and good agreement with other researchers was obtained. (Author) [pt

Association of Lead Exposure, Serum Uric Acid and Parameters of Renal Function in Nigerian Lead-Exposed Workers

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DD Alasia

2010-09-01

Full Text Available Background: The presence of hyperuricemia and renal function impairment, especially in the absence of urate stone formation is strongly suggestive of lead nephropathy. The evaluation of this association is essential in areas where lead exposure is still prevalent and uncontrolled. Objective: To determine the relationship between serum uric acid and renal function indices in lead-exposed workers. Methods: A cross-sectional study of 190 adults with occupational lead exposure and 80 adults (comparison group, matched for age and sex was performed in Port Harcourt, South-south Nigeria. Blood lead was used as the biomarker of lead exposure while serum urea, serum creatinine, urine albumin (using urine albumin:creatinine ratio, estimated glomerular filtration rate (GFR and serum uric acid were the renal function indices measured. Results: Occupationally lead-exposed subjects had a significantly (p = 0.008 higher mean±SD blood lead levels (50.37±24.58 μg/dL than the comparison group (41.40±26.85. The mean±SD serum urea (8.6±2.3 mg/dL, creatinine (1.0±0.2 mg/dL and serum uric acid (4.6±1.2 mg/dL were significantly (p < 0.01 higher in the study subjects than the comparison group (7.6±2.4, 0.9±0.2, and 3.9±1.1 mg/dL, respectively. The mean±SD creatinine clearance was significantly (p = 0.002 lower in the study subjects than the comparison group (98.9±21.3 vs. 108.2±25.2 mL/min/1.72 m2. Serum uric acid level correlated positively with serum creatinine (r = 0.134 and negatively with GFR (r = ‑0.151. Conclusion: People with occupational lead exposure are at risk of developing hyperuricemia and renal impairment.

Hot corrosion of the steel SA213-T22 and SA213-TP347H in 80% V2O5-20%Na2SO4 mixture

International Nuclear Information System (INIS)

Almeraya, F.; Martinez-Villafane, A.; Gaona, C.; Romero, M.A.; Malo, J.M.

1998-01-01

Many hot corrosion problems in industrial and utility boilers are caused by molten salts. The corrosion processes which occur in salts are of an electrochemical nature, and so they can be studied using electrochemical test methods. In this research, electrochemical techniques in molten salt systems have been used for the measurements of molten corrosion processes. Electrochemical test methods are described here for a salt mixture of 80%V 2 O 5 -20%NaSO 4 at 540-680 degree centigrade. To establish better the electrochemical corrosion rate measurements for molten salt systems, information from electrochemical potentiodynamic polarization curves, such as polarization resistance and Tafeol slopes were used in this study to generate corrosion rate data. The salt was contained in a quartz crucible inside a stainless retort. The atmosphere used was air. A thermocouple sheathed with quartz glass was introduced into the molten salt for temperature monitoring and control. Two materials were tested in the molten mixture: SA213-T22 and SA213-TP347H steels. The corrosion rates values obtained using electrochemical methods were around 0.58-7.14 mm/yr (22.9-281 mpy). The corrosion rate increase with time. (Author) 7 refs

Laser-assisted lead extraction: the European experience.

Science.gov (United States)

Kennergren, C; Bucknall, C A; Butter, C; Charles, R; Fuhrer, J; Grosfeld, M; Tavernier, R; Morgado, T B; Mortensen, P; Paul, V; Richter, P; Schwartz, T; Wellens, F

2007-08-01

The aim of this study is to investigate the safety and effectiveness of Excimer laser-assisted lead extraction in Europe. The final European multi-centre study experience is presented. The Excimer is a cool cutting laser (50 degrees C) with a wavelength of 308 nm. The energy is emitted from the tip of a flexible sheath and is absorbed by proteins and lipids, 64% of the energy is absorbed at a tissue depth of 0.06 mm. The sheath is positioned over the lead, and the fibrosis surrounding the lead is vaporized while advancing the sheath without damaging other leads. From August 1996 to March 2001, 383 leads (170 atrial, 213 ventricular) in 292 patients (mean age 61.6 years, range 13-96) were extracted at 14 European centres. Mean implantation time was 74 months (3-358). Most frequent indications were pocket infection (26%), non-functional leads (21%), patient morbidity (21%), septicaemia or endocarditis (14%), erosion (5%), and lead interference (8%). Median extraction time was 15 min (1-300). Complete extraction was achieved in 90.9% of the leads and partial extraction in 3.4%. Extraction failed in 5.7% of the leads. Major complications = perforations caused 10/22 (3.4/5.7%) of the failures. Most partially extracted patients were considered clinically successful, as only minor lead parts without clinical significance were left. Femoral non-laser technique was used to remove 8/12 of the non-complication failures. The total complication rate, including five minor complications (1.7%), was 5.1%. No in-hospital mortality occurred. Pacing and implantable cardioverter-defibrillator leads can safely, effectively, and predictably be extracted. Open-heart extractions can be limited to special cases. The results indicate that the traditional policy of abandoning redundant leads, instead of removing them, may be obsolete in many patients.

Enhanced efficacy of combined {sup 213}Bi-DTPA-F3 and paclitaxel therapy of peritoneal carcinomatosis is mediated by enhanced induction of apoptosis and G2/M phase arrest

Energy Technology Data Exchange (ETDEWEB)

Vallon, Mario; Seidl, Christof; Blechert, Birgit; Li, Zhoulei; Gaertner, Florian C.; Senekowitsch-Schmidtke, Reingard; Essler, Markus [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Gilbertz, Klaus-Peter [German Armed Forces, Institute of Radiobiology, Munich (Germany); Baumgart, Anja [Technische Universitaet Muenchen, III. Medical Department, Munich (Germany); Aichler, Michaela; Feuchtinger, Annette; Walch, Axel K. [Helmholtz Zentrum Muenchen, Institute of Pathology, Neuherberg (Germany); Bruchertseifer, Frank; Morgenstern, Alfred [Institute for Transuranium Elements, European Commission, Joint Research Centre, Karlsruhe (Germany)

2012-12-15

Targeted therapy with {alpha}-particle emitting radionuclides is a promising new option in cancer therapy. Stable conjugates of the vascular tumour-homing peptide F3 with the {alpha}-emitter {sup 213}Bi specifically target tumour cells. The aim of our study was to determine efficacy of combined {sup 213}Bi-diethylenetriaminepentaacetic acid (DTPA)-F3 and paclitaxel treatment compared to treatment with either {sup 213}Bi-DTPA-F3 or paclitaxel both in vitro and in vivo. Cytotoxicity of treatment with {sup 213}Bi-DTPA-F3 and paclitaxel, alone or in combination, was assayed towards OVCAR-3 cells using the alamarBlue assay, the clonogenic assay and flow cytometric analyses of the mode of cell death and cell cycle arrest. Therapeutic efficacy of the different treatment options was assayed after repeated treatment of mice bearing intraperitoneal OVCAR-3 xenograft tumours. Therapy monitoring was performed by bioluminescence imaging and histopathologic analysis. Treatment of OVCAR-3 cells in vitro with combined {sup 213}Bi-DTPA-F3 and paclitaxel resulted in enhanced cytotoxicity, induction of apoptosis and G2/M phase arrest compared to treatment with either {sup 213}Bi-DTPA-F3 or paclitaxel. Accordingly, i.p. xenograft OVCAR-3 tumours showed the best response following repeated (six times) combined therapy with {sup 213}Bi-DTPA-F3 (1.85 MBq) and paclitaxel (120 {mu}g) as demonstrated by bioluminescence imaging and histopathologic investigation of tumour spread on the mesentery of the small and large intestine. Moreover, mean survival of xenograft mice that received combined therapy with {sup 213}Bi-DTPA-F3 and paclitaxel was significantly superior to mice treated with either {sup 213}Bi-DTPA-F3 or paclitaxel alone. Combined treatment with {sup 213}Bi-DTPA-F3 and paclitaxel significantly increased mean survival of mice with peritoneal carcinomatosis of ovarian origin, thus favouring future therapeutic application. (orig.)

Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

Energy Technology Data Exchange (ETDEWEB)

Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

2011-02-07

Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the

Improved safety and efficacy of 213Bi-DOTATATE-targeted alpha therapy of somatostatin receptor-expressing neuroendocrine tumors in mice pre-treated with L-lysine.

Science.gov (United States)

Chan, Ho Sze; Konijnenberg, Mark W; Daniels, Tamara; Nysus, Monique; Makvandi, Mehran; de Blois, Erik; Breeman, Wouter A; Atcher, Robert W; de Jong, Marion; Norenberg, Jeffrey P

2016-12-01

Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177 Lu-DOTATATE or 90 Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological protection can reduce renal uptake of radiopeptides, e.g., positively charged amino acids, to saturate in the proximal tubules, thereby enabling higher radioactivity to be safely administered. The aim of this preclinical study was to evaluate the therapeutic effect of 213 Bi-DOTATATE with and without renal protection using L-lysine in mice. Tumor uptake and kinetics as a function of injected mass of peptide (range 0.03-3 nmol) were investigated using 111 In-DOTATATE. These results allowed estimation of the mean radiation absorbed tumor dose for 213 Bi-DOTATATE. Pharmacokinetics and dosimetry of 213 Bi-DOTATATE was determined in mice, in combination with renal protection. A dose escalation study with 213 Bi-DOTATATE was performed to determine the maximum tolerated dose (MTD) with and without pre-administration of L-lysine as for renal protection. Neutrophil gelatinase-associated lipocalin (NGAL) served as renal biomarker to determine kidney injury. The maximum mean radiation absorbed tumor dose occurred at 0.03 nmol and the minimum at 3 nmol. Similar mean radiation absorbed tumor doses were determined for 0.1 and 0.3 nmol with a mean radiation absorbed dose of approximately 0.5 Gy/MBq 213 Bi-DOTATATE. The optimal mass of injected peptide was found to be 0.3 nmol. Tumor uptake was similar for 111 In-DOTATATE and 213 Bi-DOTATATE at 0.3 nmol peptide. Lysine reduced the renal uptake of 213 Bi-DOTATATE by 50% with no effect on the tumor uptake. The MTD was <13.0 ± 1.6 MBq in absence of L-lysine and 21.7 ± 1.9 MBq with L-lysine renal protection, both imparting an LD 50 mean renal radiation absorbed dose of 20 Gy. A correlation was found between the

Strength analyses of the bubbler condenser structure of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia). Report of the IAEA Technical Co-operation Project RER/9/004 on evaluation of safety aspects of WWER-440 model 213 nuclear power plants

International Nuclear Information System (INIS)

1995-06-01

This publication addresses the topic of mechanical strength of the bubbler condenser applied in the WWER-440 model 213 plants and is intended to assist WWER-440/213 operators in the re-assessment of the bubbler condenser performance. It is hoped that it will also be useful to anyone working in the field of WWER safety, and in particular to experts planning, executing or reviewing studies related to the subject. Refs, figs and tabs

Strength analyses of the bubbler condenser structure of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia). Report of the IAEA Technical Co-operation Project RER/9/004 on evaluation of safety aspects of WWER-440 model 213 nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-06-01

This publication addresses the topic of mechanical strength of the bubbler condenser applied in the WWER-440 model 213 plants and is intended to assist WWER-440/213 operators in the re-assessment of the bubbler condenser performance. It is hoped that it will also be useful to anyone working in the field of WWER safety, and in particular to experts planning, executing or reviewing studies related to the subject. Refs, figs and tabs.

Accident loads for a VVER-440/213 containment

Energy Technology Data Exchange (ETDEWEB)

Techy, Z. [Institute for Electric Power Research (VEIKI), Budapest (Hungary); Lajtha, G. [Institute for Electric Power Research (VEIKI), Budapest (Hungary); Taubner, R. [Institute for Electric Power Research (VEIKI), Budapest (Hungary)

1995-08-01

Specific features of the VVER-440/213 containment are the subdivided rectangular building and the localization system including the bubbler trays and air traps. Accident loads are calculated for a large break loss of coolant accident (LBLOCA). The maximum pressure and temperature loads are calculated with different codes during the blowdown phase of the LBLOCA. The uncertainty margins of the maximum pressure are given in this case. Sensitivity studies are performed for different leakage rates and hydraulic data of the containment. The effects of the active and passive spray systems on the depressurization are presented in this paper. The maximum pressure loads are also examined in case of degraded conditions of the localization system. (orig.).

Somatostatin-receptor-targeted α-emitting 213Bi is therapeutically more effective than β--emitting 177Lu in human pancreatic adenocarcinoma cells

International Nuclear Information System (INIS)

Nayak, Tapan K.; Norenberg, Jeffrey P.; Anderson, Tamara L.; Prossnitz, Eric R.; Stabin, Michael G.; Atcher, Robert W.

2007-01-01

Introduction: Advance clinical cancer therapy studies of patients treated with somatostatin receptor (sstr)-targeted [DOTA 0 -Tyr 3 ]octreotide (DOTATOC) labeled with low-linear-energy-transfer (LET) β - -emitters have shown overall response rates in the range of 15-33%. In order to improve outcomes, we sought to compare the therapeutic effectiveness of sstr-targeted high-LET α-emitting 213 Bi to that of low-LET β - -emitting 177 Lu by determining relative biological effectiveness (RBE) using the external γ-beam of 137 Cs as reference radiation. Methods: Sstr-expressing human pancreatic adenocarcinoma Capan-2 cells and A549 control cells were used for this study. The effects of different radiation doses of 213 Bi and 177 Lu labeled to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid and sstr-targeted DOTATOC were investigated with a clonogenic cell survival assay. Apoptosis was measured using the Cell Death Detection ELISA PLUS 10x kit. Results: Using equimolar DOTATOC treatment with concurrent irradiation with a 137 Cs source as reference radiation, the calculated RBE of [ 213 Bi]DOTATOC was 3.4, as compared to 1.0 for [ 177 Lu]DOTATOC. As measured in terms of absorbance units, [ 213 Bi]DOTATOC caused a 2.3-fold-greater release of apoptosis-specific mononucleosomes and oligonucleosomes than [ 177 Lu]DOTATOC at the final treatment time of 96 h (P 213 Bi]DOTATOC is therapeutically more effective in decreasing survival than is [ 177 Lu]DOTATOC in human pancreatic adenocarcinoma cells due to its comparatively higher RBE

1,213 Cases of Treatment of Facial Acne Using Indocyanine Green and Intense Pulsed Light in Asian Skin

Directory of Open Access Journals (Sweden)

Kui Young Park

2015-01-01

Full Text Available Background. Photodynamic therapy (PDT has been used for acne, with various combinations of photosensitizers and light sources. Objective. We evaluated the effectiveness and safety of indocyanine green (ICG and intense pulsed light (IPL in the treatment of acne. Materials and Methods. A total of 1,213 patients with facial acne were retrospectively reviewed. Patients received three or five treatments of ICG and IPL at two-week intervals. Clinical response to treatment was assessed by comparing pre- and posttreatment clinical photographs and patient satisfaction scores. Results. Marked to excellent improvement was noted in 483 of 1,213 (39.8% patients, while minimal to moderate improvement was achieved in the remaining 730 (60.2% patients. Patient satisfaction scores revealed that 197 (16.3% of 1,213 patients were highly satisfied, 887 (73.1% were somewhat satisfied, and 129 (10.6% were unsatisfied. There were no significant side effects. Conclusion. These results suggest that PDT with ICG and IPL can be effectively and safely used in the treatment of acne.

Therapeutic efficacy and toxicity of {sup 225}Ac-labelled vs. {sup 213}Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis

Energy Technology Data Exchange (ETDEWEB)

Essler, Markus; Gaertner, Florian C.; Blechert, Birgit; Senekowitsch-Schmidtke, Reingard; Seidl, Christof [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Neff, Frauke [Helmholtz Zentrum Muenchen, Institute of Pathology, Neuherberg (Germany); Bruchertseifer, Frank; Morgenstern, Alfred [Institute for Transuranium Elements, European Commission, Joint Research Centre, Karlsruhe (Germany)

2012-04-15

Targeted delivery of alpha-particle-emitting radionuclides is a promising novel option in cancer therapy. We generated stable conjugates of the vascular tumour-homing peptide F3 both with {sup 225}Ac and {sup 213}Bi that specifically bind to nucleolin on the surface of proliferating tumour cells. The aim of our study was to determine the therapeutic efficacy of {sup 225}Ac-DOTA-F3 in comparison with that of {sup 213}Bi-DTPA-F3. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were determined via clonogenic assays. The therapeutic efficacy of both constructs was assayed by repeated treatment of mice bearing intraperitoneal MDA-MB-435 xenograft tumours. Therapy was monitored by bioluminescence imaging. Nephrotoxic effects were analysed by histology. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were 53 kBq/ml and 67 Bq/ml, respectively. The median survival of control mice treated with phosphate-buffered saline was 60 days after intraperitoneal inoculation of 1 x 10{sup 7} MDA-MB-435 cells. Therapy with 6 x 1.85 kBq of {sup 225}Ac-DOTA-F3 or 6 x 1.85 MBq of {sup 213}Bi-DTPA-F3 prolonged median survival to 95 days and 97 days, respectively. While F3 labelled with short-lived {sup 213}Bi (t{sub 1/2} 46 min) reduced the tumour mass at early time-points up to 30 days after treatment, the antitumour effect of {sup 225}Ac-DOTA-F3 (t{sub 1/2} 10 days) increased at later time-points. The difference in the fraction of necrotic cells after treatment with {sup 225}Ac-DOTA-F3 (43%) and with {sup 213}Bi-DTPA-F3 (36%) was not significant. Though histological analysis of kidney samples revealed acute tubular necrosis and tubular oedema in 10-30% of animals after treatment with {sup 225}Ac-DOTA-F3 or {sup 213}Bi-DTPA-F3, protein casts were negligible (2%), indicating only minor damage to the kidney. Therapy with both {sup 225}Ac-DOTA-F3 and {sup 213}Bi-DTPA-F3 increased survival of mice with peritoneal carcinomatosis. Mild renal toxicity of both

High-performance liquid chromatographic determination of selenium in coal after derivatization to 2,1,3-benzoselenadiazoles

Energy Technology Data Exchange (ETDEWEB)

Khuhawar, M.Y.; Bozdar, R.B.; Babar, M.A. (Sindh University, Jamshoro (Pakistan). Inst. of Chemistry)

1992-11-01

High-performance liquid chromatography was examined for the determination of selenium after derivatization to 2,1,3-benzoselenadiazoles using 1,2-diaminobenzene, 1,2-diamino-4-nitrobenzene (NDAB), 2,3-diaminonaphthalene and 3,3-diaminobenzidine as derivatizing agents. Elution was carried out using a mixture of chloroform and hexane, with ultraviolet spectrophotometric detection. The 2,1,3-benzoselenadiazoles were extracted into toluene. Linear calibrations were obtained for 0-4[mu]g of selenium in 10 cm[sup 3] of solution and the detection limits were 20-50 ng of selenium in 10 cm[sup 3] of solution. The method was applied to the determination of selenium in coal samples and a shampoo using NDAB as the derivatizing reagent in acidic solution.

Direct measurements of secondary water inventory of steam generator PGV-213 in operation

Energy Technology Data Exchange (ETDEWEB)

Tarankov, G.A.; Trunov, N.B.; Dranchenko, B.N.; Kamiagin, W.W. [OKB Gidropress (Russian Federation)

1997-12-31

Results of weight measurement of PGV-213 steam generator during filling in, heating-up and power increase are described. Special measurement system based on stress gauges has been developed. Method of derivation of secondary water inventory is described. Comparison of the data for two steam generators prove accuracy of the measurements. (orig.). 1 refs.

Direct measurements of secondary water inventory of steam generator PGV-213 in operation

Energy Technology Data Exchange (ETDEWEB)

Tarankov, G A; Trunov, N B; Dranchenko, B N; Kamiagin, W W [OKB Gidropress (Russian Federation)

1998-12-31

Results of weight measurement of PGV-213 steam generator during filling in, heating-up and power increase are described. Special measurement system based on stress gauges has been developed. Method of derivation of secondary water inventory is described. Comparison of the data for two steam generators prove accuracy of the measurements. (orig.). 1 refs.

Page 1 Heterogeneous doping effects in KC-AlO composites 213 of ...

Indian Academy of Sciences (India)

Heterogeneous doping effects in KC-AlO composites 213 of Al-O in KCl at 500°C for three different sizes of Al-O particles (0-05, 0-3 and. 1-0 um). The figure shows that as the concentration of Al Os increases, the conductivity increases slowly initially, then rather rapidly before it peaks at a 45mol%. Al2O. Moreover, as the ...

7 CFR 1.213 - Appearance as a witness on behalf of the United States.

Science.gov (United States)

2010-01-01

... Appearance of USDA Employees as Witnesses in Judicial or Administrative Proceedings § 1.213 Appearance as a... United States in any judicial or administrative proceeding without the issuance of a summons, subpoena, or other compulsory process. Employees should obtain permission for such an appearance from their...

On the Effect of Fluorination of 2,1,3-Benzothiadiazole

KAUST Repository

Nielsen, Christian B.

2015-04-22

The 4,7-dithieno-2,1,3-benzothiadiazole (DTBT) moiety and its fluorinated counterpart are important pi-conjugated building blocks in the field of organic electronics. Here we present a combined experimental and theoretical investigation into fundamental properties relating to these two molecular entities and discuss the potential impact on extended π-conjugated materials and their electronic properties. While the fluorinated derivative, in the solid state, packs with a smaller co-facial overlap than DTBT, we report experimental evidence for stronger optical absorption as well as stronger intra- and intermolecular contacts upon fluorination.

On the Effect of Fluorination of 2,1,3-Benzothiadiazole

KAUST Repository

Nielsen, Christian B.; White, Andrew J. P.; McCulloch, Iain

2015-01-01

The 4,7-dithieno-2,1,3-benzothiadiazole (DTBT) moiety and its fluorinated counterpart are important pi-conjugated building blocks in the field of organic electronics. Here we present a combined experimental and theoretical investigation into fundamental properties relating to these two molecular entities and discuss the potential impact on extended π-conjugated materials and their electronic properties. While the fluorinated derivative, in the solid state, packs with a smaller co-facial overlap than DTBT, we report experimental evidence for stronger optical absorption as well as stronger intra- and intermolecular contacts upon fluorination.

VERY LONG BASELINE INTERFEROMETRY SEARCH FOR THE RADIO COUNTERPART OF HESS J1943+213

Energy Technology Data Exchange (ETDEWEB)

Gabanyi, K. E. [Konkoly Observatory, Research Centre for Astronomy and Earth Sciences of the Hungarian Academy of Sciences, P.O. Box 67, Budapest H-1525 (Hungary); Dubner, G.; Giacani, E. [Instituto de Astronomia y Fisica del Espacio (CONICET-UBA), CC 67, Suc. 28, 1428 Buenos Aires (Argentina); Paragi, Z.; Pidopryhora, Y. [Joint Institute for VLBI in Europe, Postbus 2, 7990 AA Dwingeloo (Netherlands); Frey, S., E-mail: gabanyi@konkoly.hu [FOeMI Satellite Geodetic Observatory, P.O. Box 585, H-1592 Budapest (Hungary)

2013-01-01

HESS J1943+213, a TeV point source close to the Galactic plane recently discovered by the H.E.S.S. Collaboration, was proposed to be an extreme BL Lacertae object, though a pulsar wind nebula (PWN) nature could not be completely discarded. To investigate its nature, we performed high-resolution radio observations with the European Very Long Baseline Interferometry Network (EVN) and reanalyzed archival continuum and H I data. The EVN observations revealed a compact radio counterpart of the TeV source. The low brightness temperature and the resolved nature of the radio source are indications against the beamed BL Lacertae hypothesis. The radio/X-ray source appears immersed in a {approx}1' elliptical feature, suggesting a possible galactic origin (PWN nature) for the HESS source. We found that HESS J1943+213 is located in the interior of a {approx}1 Degree-Sign diameter H I feature and explored the possibility of them being physically related.

Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.

Science.gov (United States)

Morimoto, Takaaki; Mineharu, Yohei; Ono, Koh; Nakatochi, Masahiro; Ichihara, Sahoko; Kabata, Risako; Takagi, Yasushi; Cao, Yang; Zhao, Lanying; Kobayashi, Hatasu; Harada, Kouji H; Takenaka, Katsunobu; Funaki, Takeshi; Yokota, Mitsuhiro; Matsubara, Tatsuaki; Yamamoto, Ken; Izawa, Hideo; Kimura, Takeshi; Miyamoto, Susumu; Koizumi, Akio

2017-01-01

The genetic architecture of coronary artery disease has not been fully elucidated, especially in Asian countries. Moyamoya disease is a progressive cerebrovascular disease that is reported to be complicated by coronary artery disease. Because most Japanese patients with moyamoya disease carry the p.R4810K variant of the ring finger 213 gene (RNF213), this may also be a risk factor for coronary artery disease; however, this possibility has never been tested. We genotyped the RNF213 p.R4810K variant in 956 coronary artery disease patients and 716 controls and tested the association between p.R4810K and coronary artery disease. We also validated the association in an independent population of 311 coronary artery disease patients and 494 controls. In the replication study, the p.R4810K genotypes were imputed from genome-wide genotyping data based on the 1000 Genomes Project. We used multivariate logistic regression analyses to adjust for well-known risk factors such as dyslipidemia and smoking habits. In the primary study population, the frequency of the minor variant allele was significantly higher in patients with coronary artery disease than in controls (2.04% vs. 0.98%), with an odds ratio of 2.11 (p = 0.017). Under a dominant model, after adjustment for risk factors, the association remained significant, with an odds ratio of 2.90 (95% confidence interval: 1.37-6.61; p = 0.005). In the replication study, the association was significant after adjustment for age and sex (odds ratio = 4.99; 95% confidence interval: 1.16-21.53; p = 0.031), although it did not reach statistical significance when further adjusted for risk factors (odds ratio = 3.82; 95% confidence interval: 0.87-16.77; p = 0.076). The RNF213 p.R4810K variant appears to be significantly associated with coronary artery disease in the Japanese population.

Pulse-shape discrimination in NE213 liquid scintillator detectors

International Nuclear Information System (INIS)

Cavallaro, M.; Tropea, S.; Agodi, C.; Assié, M.; Azaiez, F.; Boiano, C.; Bondì, M.; Cappuzzello, F.; Carbone, D.; De Napoli, M.; Séréville, N. de; Foti, A.; Linares, R.; Nicolosi, D.; Scarpaci, J.A.

2013-01-01

The 16-channel fast stretcher BaFPro module, originally developed for processing signals of Barium Fluoride scintillators, has been modified to make a high performing analog pulse-shape analysis of signals from the NE213 liquid scintillators of the EDEN neutron detector array. The module produces two Gaussian signals, whose amplitudes are proportional to the height of the fast component of the output light and to the total energy deposited into the scintillator, respectively. An in-beam test has been performed at INFN-LNS (Italy) demonstrating a low detection threshold, a good pulse-shape discrimination even at low energies and a wide dynamic range for the measurement of the neutrons energy.

22 CFR 213.23 - Salary offset when USAID is not the creditor agency.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Salary offset when USAID is not the creditor... Administrative Offset § 213.23 Salary offset when USAID is not the creditor agency. (a) USAID will use salary... installment, if a date other than the next established pay period. (b) Requests for salary offset must be sent...

Physicochemical parameters influencing coaggregation between the freshwater bacteria Sphingomonas natatoria 2.1 and Micrococcus luteus 2.13.

Science.gov (United States)

Min, K R; Zimmer, M N; Rickard, A H

2010-11-01

The aim of this study was to explore the physicochemical parameters that influence coaggregation between the freshwater bacteria Sphingomonas natatoria 2.1 and Micrococcus luteus 2.13. Using visual coaggregation assays, the effect of different buffers, solutions of differing ionic strength, pH, temperature, and viscosity on the degree of coaggregation was assessed. Coaggregation occurred maximally in distilled water but was inhibited when coaggregates were suspended in a commonly-used oral bacterial coaggregation buffer, saline solutions, and Tris-Cl buffers. Coaggregation was weakly expressed in standard laboratory buffers. The ionic strength of inorganic salt solutions required to inhibit coaggregation depended upon the inorganic salt being tested. Coaggregation occurred at a pH of 3-10, between 5 and 80°C and was inhibited in solutions with a viscosity of 22.5 centipoises at 20°C. Inhibition of coaggregation with NaCl impaired biofilm development. When developing buffers to test for coaggregation, the natural liquid environment should be considered. Coaggregation between S. natatoria 2.1 and M. luteus 2.13 is only affected by physicochemical conditions beyond those typically found in natural freshwater ecosystems. Such a robust ability to coaggregate may enhance the ability of S. natatoria 2.1 and M. luteus 2.13 to develop a niche in freshwater biofilms.

The status of the Bubbler Condenser Containment System for the Reactors of the VVER-440/213 Type

International Nuclear Information System (INIS)

Karwat, H.; Rosinger, H.E.

1998-01-01

VVER-440/213 Pressurized Water Reactors have a pressure-suppression containment structure called a 'Bubbler Condenser' tower which can reduce the design pressure of the entire containment following a design basis accident (DBA), such as a loss-of-coolant accident (LOCA). The bubbler condenser pressure suppression system provides reduction of the LOCA containment pressure by the condensation of released steam in a water pool. World-wide there are 14 nuclear power plants of the VVER-440/213 type in Eastern Europe and Russia. One of the safety concerns for the VVER-440/213 reactors relates to the ability of the bubbler condenser containment system to function satisfactorily and to maintain its integrity following certain postulated accidents and thus limit the release of radioactive material to the environment. The complicated geometry of the bubbler condenser unit, and the dependence on several moving devices and interlocks are the main doubts expressed by different specialists with regard to the design. General description of the bubbler condenser containment system, the physical processes, concerns and design assessment of the bubbler condenser containment system, presentation of the OECD's Unified Bubbler Condenser Research Project (UBCRP) and the European Commission PHARE/TACIS project. Recent utility investigations are also discussed

Identifikasi Secara Serologi Galur Virus Flu Burung Subtipe H5N1 Clade 2.1.3 dan Clade 2.3.2 pada Ayam Petelur (SEROLOGICAL IDENTIFICATION OF AVIAN INFLUENZA STRAIN VIRUS SUBTYPE H5N1 CLADE 2.1.3 AND CLADE 2.3.2 FROM LAYER

Directory of Open Access Journals (Sweden)

Aprilia Kusumastuti

2015-10-01

Full Text Available The aim of the study was to know avian influenza (AI infection in field by using serology test in threemarketing area of AI vaccines. Haemagglutination inhibition methode was used in this test. There werefour antigen strains of AI subtype H5N1 clade 2.1.3 (AIstrainA/Chicken/West Java/PWT-WIJ/2006, AIstrain A/Chicken/Garut/BBVW-223/2007, AI strain A/Chicken/West Java-Nagrak/30/2007, and AI strainA/Chicken/Pekalongan/BBVW-208/2007 and 2 antigen strains of AI subtype H5N1 clade 2.3.2 (AI strainA/duck/Sukoharjo/BBVW-1428-9/2012 and AI strain A/duck/Sleman/BBVW-1463-10/2012 was used inthis study for HI test. The result presents that 93,33% chicken farms in three marketing area of PT. SanbioLaboratories have positive antibody titre to AI subtype H5N1 clade 2.1.3. This titre may be obtained fromAI clade 2.1.3 vaccination. From 15 samples, 92,86% are positive to AI subtype H5N1 clade 2.3.2A/duck/Sukoharjo/BBVW-1428-9/2012 and 92,31% are positive to A/duck/Sleman/BBVW-1463-10/2012 evenwithout AI clade 2.3.2 vaccination. This antibody titre may be obtained from AI clade 2.1.3 vaccine crossprotection or field infection.

Comparison of therapeutic efficacy and biodistribution of 213Bi- and 211At-labeled monoclonal antibody MX35 in an ovarian cancer model

DEFF Research Database (Denmark)

Gustafsson, Anna M E; Bäck, Tom; Elgqvist, Jörgen

2012-01-01

The purpose of this study was to compare the therapeutic efficacy and biodistribution of the monoclonal antibody MX35 labeled with either (213)Bi or (211)At, both α-emitters, in an ovarian cancer model.......The purpose of this study was to compare the therapeutic efficacy and biodistribution of the monoclonal antibody MX35 labeled with either (213)Bi or (211)At, both α-emitters, in an ovarian cancer model....

Role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins

Energy Technology Data Exchange (ETDEWEB)

van Maanen, J.M.; de Ruiter, C.; de Vries, J.; Kootstra, P.R.; Gobas, F.; Pinedo, H.M.

1985-09-01

Covalent binding of /sup 3/H-labeled VP 16-213 to rat liver and HeLa cell microsomal proteins was studied in vitro. Metabolic activation by cytochrome P-450 was found to play a role in the covalent binding of VP 16-213 to rat liver microsomal proteins, as shown by the need of NADPH cofactor, the increased binding after phenobarbital pretreatment and the inhibition by SFK-525A. Addition of ascorbic acid or alpha-phenyl-N-tert. butylnitrone to the incubation mixture depressed covalent binding by about 85%, suggesting that formation of a reactive metabolite from the phenolic structure may be involved in the binding process. VP 16-213 did not inhibit aminopyrine N-demethylase at the concentration used in the binding experiments (17 microM), indicating that metabolism of its methylenedioxy group does not play a role in binding to microsomal proteins. HeLa cell microsomes were found to possess aminopyrine N-demethylase activity. Covalent binding of radiolabeled VP 16-213 to HeLa cell microsomes decreased by about 64% if NADPH was omitted.

27 CFR 25.213 - Beer returned to brewery other than that from which removed.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Beer returned to brewery... AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Beer Returned to Brewery § 25.213 Beer returned to brewery other than that from which removed. (a) Refund or adjustment of tax...

213Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience

International Nuclear Information System (INIS)

Kratochwil, C.; Giesel, F.L.; Mier, W.; Haberkorn, U.; Bruchertseifer, F.; Apostolidis, C.; Morgenstern, A.; Boll, R.; Murphy, K.

2014-01-01

Radiopeptide therapy using a somatostatin analogue labelled with a beta emitter such as 90 Y/ 177 Lu-DOTATOC is a new therapeutic option in neuroendocrine cancer. Alternative treatments for patients with refractory disease are rare. Here we report the first-in-human experience with 213 Bi-DOTATOC targeted alpha therapy (TAT) in patients pretreated with beta emitters. Seven patients with progressive advanced neuroendocrine liver metastases refractory to treatment with 90 Y/ 177 Lu-DOTATOC were treated with an intraarterial infusion of 213 Bi-DOTATOC, and one patient with bone marrow carcinosis was treated with a systemic infusion of 213 Bi-DOTATOC. Haematological, kidney and endocrine toxicities were assessed according to CTCAE criteria. Radiological response was assessed with contrast-enhanced MRI and 68 Ga-DOTATOC-PET/CT. More than 2 years of follow-up were available in seven patients. The biodistribution of 213 Bi-DOTATOC was evaluable with 440 keV gamma emission scans, and demonstrated specific tumour binding. Enduring responses were observed in all treated patients. Chronic kidney toxicity was moderate. Acute haematotoxicity was even less pronounced than with the preceding beta therapies. TAT can induce remission of tumours refractory to beta radiation with favourable acute and mid-term toxicity at therapeutic effective doses. (orig.)

25 CFR 213.24 - Rate of rents and royalties on oil and gas leases.

Science.gov (United States)

2010-04-01

... Section 213.24 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF... of the oil of the same gravity, and gas, and/or natural gasoline, and/or all other hydrocarbon... storage longer than 30 days after the end of the calendar month in which said oil is produced. The lessee...

Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients

Energy Technology Data Exchange (ETDEWEB)

Hitomi, Toshiaki [Department of Health and Environmental Sciences, Kyoto University, Kyoto (Japan); Habu, Toshiyuki [Radiation Biology Center, Kyoto University, Kyoto (Japan); Kobayashi, Hatasu; Okuda, Hiroko; Harada, Kouji H. [Department of Health and Environmental Sciences, Kyoto University, Kyoto (Japan); Osafune, Kenji [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Taura, Daisuke; Sone, Masakatsu [Department of Medicine and Clinical Science, Kyoto University, Kyoto (Japan); Asaka, Isao; Ameku, Tomonaga; Watanabe, Akira; Kasahara, Tomoko; Sudo, Tomomi; Shiota, Fumihiko [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Hashikata, Hirokuni; Takagi, Yasushi [Department of Neurosurgery, Kyoto University,Kyoto (Japan); Morito, Daisuke [Faculty of Life Sciences, Kyoto Sangyo University, Kyoto (Japan); Miyamoto, Susumu [Department of Neurosurgery, Kyoto University,Kyoto (Japan); Nakao, Kazuwa [Department of Medicine and Clinical Science, Kyoto University, Kyoto (Japan); Koizumi, Akio, E-mail: koizumi.akio.5v@kyoto-u.ac.jp [Department of Health and Environmental Sciences, Kyoto University, Kyoto (Japan)

2013-08-16

Highlights: •Angiogenic activities were reduced in iPSECs from MMD patients. •Many mitosis-regulated genes were downregulated in iPSECs from MMD patients. •RNF213 R4810K downregulated Securin and inhibited angiogenic activity. •Securin suppression by siRNA reduced angiogenic activities of iPSECs and HUVECs. -- Abstract: Moyamoya disease (MMD) is a cerebrovascular disease characterized by occlusive lesions in the circle of Willis. The RNF213 R4810K polymorphism increases susceptibility to MMD. Induced pluripotent stem cells (iPSCs) were established from unaffected fibroblast donors with wild-type RNF213 alleles, and from carriers/patients with one or two RNF213 R4810K alleles. Angiogenic activities of iPSC-derived vascular endothelial cells (iPSECs) from patients and carriers were lower (49.0 ± 19.4%) than from wild-type subjects (p < 0.01). Gene expression profiles in iPSECs showed that Securin was down-regulated (p < 0.01) in carriers and patients. Overexpression of RNF213 R4810K downregulated Securin, inhibited angiogenic activity (36.0 ± 16.9%) and proliferation of humanumbilical vein endothelial cells (HUVECs) while overexpression of RNF213 wild type did not. Securin expression was downregulated using RNA interference techniques, which reduced the level of tube formation in iPSECs and HUVECs without inhibition of proliferation. RNF213 R4810K reduced angiogenic activities of iPSECs from patients with MMD, suggesting that it is a promising in vitro model for MMD.

Design basis and design features of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia)

International Nuclear Information System (INIS)

1994-05-01

The prime objective of the IAEA Technical Co-operation Project on Evaluation of Safety Aspects of WWER-440 model 213 NPPs is to co-ordinate and to integrate assistance to national organizations in studying selected aspects of safety for the same type of reactors. Consequently, the study integrated the results generated by national activities carried out in the Czech Republic, Hungary, Slovakia and Ukraine and co-ordinated through the IAEA. Valuable assistance in carrying out the tasks was also provided by Bulgaria and Poland. A set of publications is being prepared to present the results of the project. The publications are intended to facilitate the review and utilization of the results of the project. They are also providing assistance in further refinement and/or extension of plant specific safety evaluation of model 213 NPPs. This Technical Document addressing the design basis and safety related design features of WWER-440 model 213 plants is the first of the series to be published. It is hoped that this document will be useful to anyone working in the field of WWER safety, and in particular to experts planning, executing or reviewing studies related to the subject. Refs, 36 figs, tabs

Hot corrosion of the steel SA213-T22 and SA213-TP347H in 80% V{sub 2}O{sub 5}-20%Na{sub 2}SO{sub 4} mixture; Corrosion por depositos salinos de los aceros SA213-T22 y SA213-TP347H en presencia de una mezcal 80%V{sub 2} O{sub 5}-20%Na{sub 2}SO{sub 4}

Energy Technology Data Exchange (ETDEWEB)

Almeraya, F; Martinez-Villafane, A; Gaona, C; Romero, M A; Malo, J M

1998-06-01

Many hot corrosion problems in industrial and utility boilers are caused by molten salts. The corrosion processes which occur in salts are of an electrochemical nature, and so they can be studied using electrochemical test methods. In this research, electrochemical techniques in molten salt systems have been used for the measurements of molten corrosion processes. Electrochemical test methods are described here for a salt mixture of 80%V{sub 2}O{sub 5}-20%NaSO{sub 4} at 540-680 degree centigree. To establish better the electrochemical corrosion rate measurements for molten salt systems, information from electrochemical potentiodynamic polarization curves, such as polarization resistance and Tafeol slopes were used in this study to generate corrosion rate data. The salt was contained in a quartz crucible inside a stainless retort. The atmosphere used was air. A thermocouple sheathed with quartz glass was introduced into the molten salt for temperature monitoring and control. Two materials were tested in the molten mixture: SA213-T22 and SA213-TP347H steels. The corrosion rates values obtained using electrochemical methods were around 0.58-7.14 mm/yr (22.9-281 mpy). The corrosion rate increase with time. (Author) 7 refs.

Therapeutic Efficacy of Alpha-RIT Using a (213)Bi-Anti-hCD138 Antibody in a Mouse Model of Ovarian Peritoneal Carcinomatosis.

Science.gov (United States)

Derrien, Aurélie; Gouard, Sébastien; Maurel, Catherine; Gaugler, Marie-Hélène; Bruchertseifer, Frank; Morgenstern, Alfred; Faivre-Chauvet, Alain; Classe, Jean-Marc; Chérel, Michel

2015-01-01

Ovarian peritoneal carcinomatosis is a pathology for which effective cures are currently lacking. New research protocols seek to eradicate residual micrometastases following cytoreductive surgery by using hyperthermic intraperitoneal chemotherapy (HIPEC) or radioimmunotherapy (RIT). This study aims to first develop alpha-RIT using an anti-CD138 mAb radiolabeled with an alpha-emitter, bismuth-213 ((213)Bi-B-B4) and HIPEC in a nude mouse model and second to compare and combine these techniques. A murine model of postoperative ovarian peritoneal carcinomatosis was established. A pilot group of six mice received an intraperitoneal injection of luciferase-tagged SHIN-3 cells and bioluminescence was measured every day. Cytoreductive surgery was performed at day 14 (n = 4) and 29 (n = 2). Because the residual bioluminescence signal measured after surgery was equivalent to that obtained 3 days after the graft, HIPEC or alpha-RIT treatments were applied 3 days after the graft. Ten mice were treated by HIPEC with cisplatine (37.5 mg/mL), 11 with 7.4 MBq of (213)Bi-B-B4, seven with 11.1 MBq of (213)Bi-B-B4, and 10 mice were treated with the combined therapy (HIPEC + 7.4 MBq of (213)Bi-B-B4). Eleven mice received no treatment. Bioluminescence imaging and survival were assessed. Alpha-RIT 7.4 MBq and 11.1 MBq significantly improved survival (p = 0.0303 and p = 0.0070, respectively), whereas HIPEC and HIPEC + alpha-RIT treatments did not significantly ameliorate survival as compared to the control group. Survival was significantly increased by alpha-RIT treatment in mice with peritoneal carcinomatosis of ovarian origin; however, HIPEC alone or in combination with alpha-RIT had no significant effect.

Monte Carlo simulation of neutron detection efficiency for NE213 scintillation detector

International Nuclear Information System (INIS)

Xi Yinyin; Song Yushou; Chen Zhiqiang; Yang Kun; Zhangsu Yalatu; Liu Xingquan

2013-01-01

A NE213 liquid scintillation neutron detector was simulated by using the FLUKA code. The light output of the detector was obtained by transforming the secondary particles energy deposition using Birks formula. According to the measurement threshold, detection efficiencies can be calculated by integrating the light output. The light output, central efficiency and the average efficiency as a function of the front surface radius of the detector, were simulated and the results agreed well with experimental results. (authors)

Rare RNF213 variants in the C-terminal region encompassing the RING-finger domain are associated with moyamoya angiopathy in Caucasians.

Science.gov (United States)

Guey, Stéphanie; Kraemer, Markus; Hervé, Dominique; Ludwig, Thomas; Kossorotoff, Manoëlle; Bergametti, Françoise; Schwitalla, Jan Claudius; Choi, Simone; Broseus, Lucile; Callebaut, Isabelle; Genin, Emmanuelle; Tournier-Lasserve, Elisabeth

2017-08-01

Moyamoya angiopathy (MMA) is a cerebral angiopathy affecting the terminal part of internal carotid arteries. Its prevalence is 10 times higher in Japan and Korea than in Europe. In East Asian countries, moyamoya is strongly associated to the R4810K variant in the RNF213 gene that encodes for a protein containing a RING-finger and two AAA+ domains. This variant has never been detected in Caucasian MMA patients, but several rare RNF213 variants have been reported in Caucasian cases. Using a collapsing test based on exome data from 68 European MMA probands and 573 ethnically matched controls, we showed a significant association between rare missense RNF213 variants and MMA in European patients (odds ratio (OR)=2.24, 95% confidence interval (CI)=(1.19-4.11), P=0.01). Variants specific to cases had higher pathogenicity predictive scores (median of 24.2 in cases versus 9.4 in controls, P=0.029) and preferentially clustered in a C-terminal hotspot encompassing the RING-finger domain of RNF213 (P<10 -3 ). This association was even stronger when restricting the analysis to childhood-onset and familial cases (OR=4.54, 95% CI=(1.80-11.34), P=1.1 × 10 -3 ). All clinically affected relatives who were genotyped were carriers. However, the need for additional factors to develop MMA is strongly suggested by the fact that only 25% of mutation carrier relatives were clinically affected.

{sup 213}Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience

Energy Technology Data Exchange (ETDEWEB)

Kratochwil, C.; Giesel, F.L.; Mier, W.; Haberkorn, U. [University Hospital Heidelberg, Department of Nuclear Medicine, Heidelberg (Germany); Bruchertseifer, F.; Apostolidis, C.; Morgenstern, A. [European Commission, Institute for Transuranium Elements, Karlsruhe (Germany); Boll, R.; Murphy, K. [Oak Ridge National Laboratory, Oak Ridge, TN (United States)

2014-11-15

Radiopeptide therapy using a somatostatin analogue labelled with a beta emitter such as {sup 90}Y/{sup 177}Lu-DOTATOC is a new therapeutic option in neuroendocrine cancer. Alternative treatments for patients with refractory disease are rare. Here we report the first-in-human experience with {sup 213}Bi-DOTATOC targeted alpha therapy (TAT) in patients pretreated with beta emitters. Seven patients with progressive advanced neuroendocrine liver metastases refractory to treatment with {sup 90}Y/{sup 177}Lu-DOTATOC were treated with an intraarterial infusion of {sup 213}Bi-DOTATOC, and one patient with bone marrow carcinosis was treated with a systemic infusion of {sup 213}Bi-DOTATOC. Haematological, kidney and endocrine toxicities were assessed according to CTCAE criteria. Radiological response was assessed with contrast-enhanced MRI and {sup 68}Ga-DOTATOC-PET/CT. More than 2 years of follow-up were available in seven patients. The biodistribution of {sup 213}Bi-DOTATOC was evaluable with 440 keV gamma emission scans, and demonstrated specific tumour binding. Enduring responses were observed in all treated patients. Chronic kidney toxicity was moderate. Acute haematotoxicity was even less pronounced than with the preceding beta therapies. TAT can induce remission of tumours refractory to beta radiation with favourable acute and mid-term toxicity at therapeutic effective doses. (orig.)

77 FR 2743 - Recovery Directorate Fact Sheet 9580.213, Residential Electrical Meter Repair-“Power Up”

Science.gov (United States)

2012-01-19

...] Recovery Directorate Fact Sheet 9580.213, Residential Electrical Meter Repair--``Power Up'' AGENCY: Federal..., Residential Electrical Meter Repair--``Power Up.'' DATES: Comments must be received by February 21, 2012... authority, FEMA may fund the repair of residential electrical meters damaged in a major disaster or...

Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro

International Nuclear Information System (INIS)

Yalowich, J.C.; Goldman, I.D.

1984-01-01

Uptake of 3 H after exposure of cells to [ 3 H]-thymidine is characterized by a rapid initial velocity that approximates membrane transport followed by a slower rate of uptake that parallels the accumulation of phosphorylated derivatives of thymidine, primarily thymidine triphosphate, within the cell. The high rate of thymidine transport relative to thymidine metabolism to the triphosphate within the cell decreases as the extracellular nucleoside concentration is reduced due to a much greater decrease in membrane transport than the subsequent metabolic step. Hence, as extracellular thymidine is decreased, transport becomes increasingly rate limiting to metabolism within the cell. VP-16-213 (etoposide) or podophyllotoxin inhibits the initial uptake rate for thymidine and, as a consequence, inhibits the intracellular formation of thymidine triphosphate. When extracellular thymidine is high, inhibitory effects on transport are transient, and the net rate of thymidine triphosphate accumulation within drug-treated cells rapidly approaches a velocity comparable to that of control cells, indicating no direct VP-16-213 or podophyllotoxin effect on nucleoside and nucleotide phosphorylation. When extracellular thymidine is reduced so that transport is rate limiting to metabolism, the duration of the inhibitory effects of VP-16-213 on thymidine triphosphate formation is prolonged. A secondary effect of VP-16-213 becomes manifest beyond 10 min of incubation with [3H]thymidine with the virtual complete cessation of thymidine incorporation into the acid precipitate without any change in the thymidine triphosphate level. This late effect is not observed with podophyllotoxin and indicates a direct effect of VP-16-213 on DNA synthesis that is distinct from the earlier inhibitory effect on thymidine phosphorylation, which is secondary to membrane transport

Substituted 2,1,3-Benzothiadiazole- And Thiophene-Based Polymers for Solar Cells - Introducing a New Thermocleavable Precursor

DEFF Research Database (Denmark)

Petersen, Martin Helgesen; Gevorgyan, Suren; Krebs, Frederik C

2009-01-01

Alkoxysubstituted and unsubstituted 2,1,3-benzothiadiazoles were prepared and copolymerized with substituted and unsubstituted thiophenes using both Stille and Yamamoto cross-coupling reactions. One class of the materials bore thermally labile ester groups. The materials were all found to have...

COOLC, Ne-213 Liquid Scintillation Detector Neutron Spectra Unfolding

International Nuclear Information System (INIS)

1971-01-01

1 - Nature of physical problem solved: COOLC is designed to calculate a neutron energy spectrum from a pulse-height spectrum produced by a detector system using the liquid scintillator NE-213. 2 - Method of solution: The program estimates the counts which would be observed in an ideal detector system having a response which is specified by the user. The solution implicitly takes into account the non-negativity of the desired neutron spectrum. The solution is obtained by finding a nearly optimal combination of slices through the spectrometer response functions such that their sum approximates the response of a channel of the ideal analyzer, and then uses the coefficients so determined to obtain an estimate of the desired neutron spectrum. 3 - Restrictions on the complexity of the problem: There are none noted

Apparently balanced t(1;7)(q21.3;q34) in an infant with Coffin-Siris syndrome.

Science.gov (United States)

McPherson, E W; Laneri, G; Clemens, M M; Kochmar, S J; Surti, U

1997-09-05

Coffin-Siris syndrome is a multiple anomaly/mental retardation syndrome characterized by "coarse" facial appearance, hypoplastic or absent nails on the fifth digits, generalized hirsutism with sparse scalp hair, hypotonia, and developmental delay. Due to several reports of affected sibs with or without a mildly affected parent, both autosomal recessive and autosomal dominant inheritance have been suggested. All previous patients with well-documented Coffin-Siris syndrome are chromosomally normal, and the gene has not been mapped. We report on an infant with typical findings of Coffin-Siris syndrome who also has a de novo apparently balanced translocation of chromosomes 1 and 7, karyotype 46,XY,t(1;7)(q21.3;q34). The parental chromosomes are normal and none of the relatives have signs of Coffin-Siris syndrome. The breakpoints 1q21.3 and 7q34 are suggested as possible locations for a Coffin-Siris gene.

Neutron response matrix for unfolding NE-213 measurements to 21 MeV

International Nuclear Information System (INIS)

Ingersoll, D.T.; Wehring, B.W.; Johnson, R.H.

1976-01-01

A neutron response matrix from measured neutron responses of NE-213 in the energy range of 0.2 to 22 MeV is presented. An interpolation scheme was used to construct an 81-column matrix from the data of Verbinski, Burrus, Love, Zobel, and Hill. As a test of the new response matrix, the Cf-252 neutron spectrum was measured and unfolded using the new response matrix and the FORIST unfolding code. The spectrum agrees well with previous measurements at lower energies, while providing new information above 8 MeV

The 1:1 adduct of caffeine and 2-(1,3-dioxoisoindolin-2-ylacetic acid

Directory of Open Access Journals (Sweden)

Moazzam H. Bhatti

2011-09-01

Full Text Available In the crystal structure of the title adduct [systematic name: 2-(1,3-dioxoisoindolin-2-ylacetic acid–1,3,7-trimethyl-1,2,3,6-tetrahydro-7H-purine-2,6-dione (1/1], C8H10N4O2·C10H7NO4, the components are linked by an O—H...N hydrogen-bond and no proton transfer occurs.

Assessment of In-vessel corium retention for VVER-440/V213

International Nuclear Information System (INIS)

Matejovic, P.; Barnak, M.; Bachraty, M.; Berky, R.

2011-01-01

In-vessel corium retention (IVR) via external reactor vessel cooling (ERVC) has been recognised as a feasible and promising severe accident management strategy for VVER-440/V213 reactors. In general, the avoiding of boiling crisis on outer (cooled) RPV (reactor pressure vessel) surface is sufficient condition for preserving the RPV integrity. The crucial point of the proposed IVR concept for VVER-440/V213 is the narrow gap between elliptical lower head and thermal and biological shield. In the cold conditions the width of this gap is only about 2 cm and would be even lower in hot IVR conditions, when the reactor wall is subjected to large thermal gradients due to temperature difference between the hot inner surface (loaded by corium) and cold outer surface (which is cooled by water in flooded cavity). Sufficient gap should remain free for coolant flow for the success of the proposed IVR concept. Thus, realistic estimation of thermal load and corresponding deformations of reactor wall and their impact on gap width are of primarily importance. Two different approaches were used for the estimation of the thermal load: a conservative approach and a transient approach, both were computed with the ASTEC code. The structural analysis of RPV subjected to IVR load was performed using the finite element method (FEM) code ANSYS release 10.0. From the results obtained it follows, that even when the RPV is subjected to limiting loading conditions during severe accident, there should be sufficient gap width (∼ 1 cm) between RPV wall and thermal/biological shield for the coolant flow in natural circulation regime alongside the outer surface of the RPV wall

Safety assessment of unit 5 (WWER-440/W-213) of the Greifswald nuclear power station

International Nuclear Information System (INIS)

1992-02-01

The report represents the common results of the program of German-Soviet cooperation in reactor safety and radiation protection. The technical plant and features of type WWER-440/W-213 nuclear power plants, basic legal licensing principles, reactor core and pressurized components, load resulting from accidents, systems engineering, spreading impacts, civil engineering aspects, and the evaluation of operating experience are described. (DG)

Neutron-Gamma Pulse Shape Discrimination With Ne-213 Liquid Scintillator By Using Digital Signal Processing Combined With Similarity Method

International Nuclear Information System (INIS)

Mardiyanto

2008-01-01

Neutron-Gamma Pulse Shape Discrimination with a NE-213 Liquid Scintillator by Using Digital Signal Processing Combined with Similarity Method. Measurement of mixed neutron-gamma radiation is difficult because a nuclear detector is usually sensitive to both radiations. A new attempt of neutron-gamma pulse shape discrimination for a NE-213 liquid scintillator is presented by using digital signal processing combined with an off-line similarity method. The output pulse shapes are digitized with a high speed digital oscilloscope. The n-γ discrimination is done by calculating the index of each pulse shape, which is determined by the similarity method, and then fusing it with its corresponding pulse height. Preliminary results demonstrate good separation of neutron and gamma-ray signals from a NE-213 scintillator with a simple digital system. The results were better than those with a conventional rise time method. Figure of Merit is used to determine the quality of discrimination. The figure of merit of the discrimination using digital signal processing combined with off-line similarity method are 1.9; 1.7; 1.1; 1.1; and 0.8; on the other hand by using conventional method the rise time are 0.9; 0.9; 0.9; 0.7; and 0.4 for the equivalent electron energy of 800; 278; 139; 69; and 30 keV. (author)

Salmonella Typhimurium ST213 is associated with two types of IncA/C plasmids carrying multiple resistance determinants.

Science.gov (United States)

Wiesner, Magdalena; Calva, Edmundo; Fernández-Mora, Marcos; Cevallos, Miguel A; Campos, Freddy; Zaidi, Mussaret B; Silva, Claudia

2011-01-11

Salmonella Typhimurium ST213 was first detected in the Mexican Typhimurium population in 2001. It is associated with a multi-drug resistance phenotype and a plasmid-borne blaCMY-2 gene conferring resistance to extended-spectrum cephalosporins. The objective of the current study was to examine the association between the ST213 genotype and blaCMY-2 plasmids. The blaCMY-2 gene was carried by an IncA/C plasmid. ST213 strains lacking the blaCMY-2 gene carried a different IncA/C plasmid. PCR analysis of seven DNA regions distributed throughout the plasmids showed that these IncA/C plasmids were related, but the presence and absence of DNA stretches produced two divergent types I and II. A class 1 integron (dfrA12, orfF and aadA2) was detected in most of the type I plasmids. Type I contained all the plasmids carrying the blaCMY-2 gene and a subset of plasmids lacking blaCMY-2. Type II included all of the remaining blaCMY-2-negative plasmids. A sequence comparison of the seven DNA regions showed that both types were closely related to IncA/C plasmids found in Escherichia, Salmonella, Yersinia, Photobacterium, Vibrio and Aeromonas. Analysis of our Typhimurium strains showed that the region containing the blaCMY-2 gene is inserted between traA and traC as a single copy, like in the E. coli plasmid pAR060302. The floR allele was identical to that of Newport pSN254, suggesting a mosaic pattern of ancestry with plasmids from other Salmonella serovars and E. coli. Only one of the tested strains was able to conjugate the IncA/C plasmid at very low frequencies (10-7 to 10-9). The lack of conjugation ability of our IncA/C plasmids agrees with the clonal dissemination trend suggested by the chromosomal backgrounds and plasmid pattern associations. The ecological success of the newly emerging Typhimurium ST213 genotype in Mexico may be related to the carriage of IncA/C plasmids. We conclude that types I and II of IncA/C plasmids originated from a common ancestor and that the

Measurements of the proton light output function of the organic liquid scintillator NE213 in several detectors

Energy Technology Data Exchange (ETDEWEB)

Hawkes, N.P.; Adams, J.M.; Bond, D.S.; Croft, S; Jarvis, O.N. E-mail: onj@jet.uk; Watkins, N

2002-01-01

When using an organic liquid scintillator such as NE213 for neutron spectrometry, the light output as a function of proton energy is needed in order to unfold the neutron spectrum from the scintillator's pulse height distribution. We have measured this function for several detectors over the range 1.5-16 MeV approximately, using monoenergetic neutrons from the Harwell 5 MV Van de Graaff accelerator. Results were obtained for a wide variety of sizes and shapes of the scintillator cell, and were found to be essentially in agreement within errors. The results were also compared with those of several other workers (amongst whom there is considerable disagreement). Below 10 MeV, there is excellent agreement with one worker and moderate or poor agreement with others; above 10 MeV, agreement is moderate in all cases. We conclude that workers wishing to unfold neutron spectra from NE213 pulse height distributions would be advised to make measurements with their own particular detector configuration, rather than use published functions.

Experience from operation of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia). Report of the IAEA technical co-operation project RER/9/004 on evaluation of safety aspects of WWER-440 model 213 nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-07-01

This TECDOC provides a comprehensive review of the operational experience with WWER-440/213 plants. It is hoped that it will be useful to anyone working in the field of WWER safety, and in particular to experts planning, executing or reviewing studies related to the subject. Refs, figs and tabs.

Experience from operation of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia). Report of the IAEA technical co-operation project RER/9/004 on evaluation of safety aspects of WWER-440 model 213 nuclear power plants

International Nuclear Information System (INIS)

1995-07-01

This TECDOC provides a comprehensive review of the operational experience with WWER-440/213 plants. It is hoped that it will be useful to anyone working in the field of WWER safety, and in particular to experts planning, executing or reviewing studies related to the subject. Refs, figs and tabs

Draft Genome Sequence of Leuconostoc mesenteroides 213M0, Isolated from Traditional Fermented Mare Milk Airag in Bulgan Aimag, Mongolia

OpenAIRE

Morita, Hidetoshi; Toh, Hidehiro; Oshima, Kenshiro; Nakano, Akiyo; Hano, Chihiro; Yoshida, Saki; Bolormaa, Tsognemekh; Burenjargal, Sedkhuu; Nguyen, Co Thi Kim; Tashiro, Kosuke; Arakawa, Kensuke; Miyamoto, Taku

2016-01-01

Leuconostoc mesenteroides 213M0 was isolated from traditional fermented mare milk airag in Bulgan Aimag, Mongolia. This strain produces a listericidal bacteriocin-like inhibitory substance. Here, we report the draft genome sequence of this organism.

Protection level of AI H5N1 vaccine clade 2.1.3 commercial against AI H5N1 clade 2.3.2 virus from Ducks to SPF chicken in laboratory conditions

Directory of Open Access Journals (Sweden)

Indriani R

2015-03-01

Full Text Available Highly Pathogenic Avian Influenza (HPAI subtype H5N1 clade 2.3.2 has infected chickens in farms, causing mortality and a decrease in egg production. Vaccination is one of the strategies to control disease of AI subtype H5N1. AI H5N1 clade 2.1.3 vaccine is available commercially. The effectiveness of two vaccines of AI H5N1 clade 2.1.3 (product A and B, and AI H5N1 clade 2.3.2 (Sukoharjo against AI H5N1 clade 2.3.2 (Sukoharjo virus SPF chickens was tested in laboratory. Four groups of SPF chickens were used in this study, there were (1 vaccinated with H5N1 clade 2.1.3 (product A, (2 vaccinated with H5N1 clade 2.1.3 (product B, (3 vaccinated with AI H5N1 clade 2.3.2 and (4 unvaccinated (as a control. Each vaccinated group consisted of 10 chicken except 8 chicken for control group. SPF chicken were vaccinated with 1 dose of vaccine at 3 weeks olds, and then after 3 weeks post vaccination (at 6 weeks olds. All group of chicken were challenged with 106 EID50 per 0.1 ml via intranasal. The results showed, chicken vaccinated with H5N1 clade 2.1.3 product A and B gave 100 and 80% protection respectively, but showed challenged virus shedding, whereas vaccine of H5N1 clade 2.3.2 gave 100% protection from mortality and without virus shedding. Vaccines of AI H5N1 clade 2.1.3 product A was better than vaccine product B, and when chicken vaccinated against H5N1 clade 2.3.2, H5N1 clade 2.3.2 vaccine was the best to be used. In order to protect chicken from AI subtype H5N1 clade 2.1.3 and 2.3.2 in the field, a bivalent vaccine of H5N1 clade 2.1.3 and 2.3.2 subtypes should be developed.

Experimental design verification of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia). Report of the IAEA technical co-operation project RER/9/004 on evaluation of safety aspects of WWER-440 model 213 nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-07-01

This publication addresses the experimental research supporting the design of WWER-440 model 213 plants. it is hoped that the material presented will be useful for experts working in the field of WWER safety, and in particular to those planning, executing or reviewing studies related to the subject. Refs, figs and tabs.

Experimental design verification of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia). Report of the IAEA technical co-operation project RER/9/004 on evaluation of safety aspects of WWER-440 model 213 nuclear power plants

International Nuclear Information System (INIS)

1995-07-01

This publication addresses the experimental research supporting the design of WWER-440 model 213 plants. it is hoped that the material presented will be useful for experts working in the field of WWER safety, and in particular to those planning, executing or reviewing studies related to the subject. Refs, figs and tabs

Contrasting controls on arsenic and lead budgets for a degraded peatland catchment in Northern England

International Nuclear Information System (INIS)

Rothwell, James J.; Taylor, Kevin G.; Evans, Martin G.; Allott, Timothy E.H.

2011-01-01

Atmospheric deposition of trace metals and metalloids from anthropogenic sources has led to the contamination of many European peatlands. To assess the fate and behaviour of previously deposited arsenic and lead, we constructed catchment-scale mass budgets for a degraded peatland in Northern England. Our results show a large net export of both lead and arsenic via runoff (282 ± 21.3 gPb ha -1 y -1 and 60.4 ± 10.5 gAs ha -1 y -1 ), but contrasting controls on this release. Suspended particulates account for the majority of lead export, whereas the aqueous phase dominates arsenic export. Lead release is driven by geomorphological processes and is a primary effect of erosion. Arsenic release is driven by the formation of a redox-dynamic zone in the peat associated with water table drawdown, a secondary effect of gully erosion. Degradation of peatland environments by natural and anthropogenic processes has the potential to release the accumulated pool of legacy contaminants to surface waters. - Highlights: → The fluvial outputs of arsenic and lead in the degraded peatland are an order-of-magnitude greater than atmospheric inputs. → The particulate phase dominates fluvial lead export, whereas the aqueous phase dominates fluvial arsenic export. → Lead export is a primary effect of peat erosion, whereas arsenic export is a secondary effect of peat erosion. - Degraded peatlands can be significant sources of previously deposited arsenic and lead

A Case with 46,XX,dup(X(q21.3q24 karyotype

Directory of Open Access Journals (Sweden)

Selda Şimşek

2010-03-01

Full Text Available The relationship between phenotype and Xq duplicationsin females remains unclear. Some females are normal;some have short stature; and others have features suchas microcephaly, developmental delay/mental retardation,body asymmetries, and gonadal dysgenesis. Somefeatures in these females resemble those in Turner syndrome.We, herein, presented a 15 years-old girl withshort stature and primary amenorrhea, who was referredto cytogenetic laboratory. Through karyotipe analysis performedby Giemsa banding technique, the patient wasdetermined to have positive Barr body and 46,XX,dup(X(q21.3q24 chromosomal constitution. Case was discussedaccording to information of present literatures.

The quantification of gluconeogenesis in healthy men by (2)H2O and [2-(13)C]glycerol yields different results: rates of gluconeogenesis in healthy men measured with (2)H2O are higher than those measured with [2-(13)C]glycerol

NARCIS (Netherlands)

Ackermans, M. T.; Pereira Arias, A. M.; Bisschop, P. H.; Endert, E.; Sauerwein, H. P.; Romijn, J. A.

2001-01-01

The quantification of gluconeogenesis (GNG) by (2)H2O and [2-(13)C]glycerol and the mass isotopomer dilution analysis of glucose does not involve assumptions regarding the enrichment of the oxaloacetate precursor pool. To compare these two methods we measured GNG in six healthy postabsorptive males

Clinical, genetic, biochemical, and testicular biopsy findings among 1,213 men evaluated for infertility

DEFF Research Database (Denmark)

Olesen, Inge Ahlmann; Andersson, Anna-Maria; Aksglaede, Lise

2017-01-01

OBJECTIVE: To study the pathologic findings among men evaluated for infertility. DESIGN: A retrospective, single-center, cross-sectional study. SETTING: University hospital-based research center. PARTICIPANT(S): We included data from 1,213 medical records from infertile men referred for diagnostic......-only syndrome: n = 23; spermatogenic arrest: n = 7; impaired spermatogenesis and atrophy: n = 28). Additionally, in idiopathic infertile men and infertile men with additional symptoms of testicular dysgenesis syndrome, 22.5% presented with a degree of Leydig cell insufficiency, with the highest frequency (33.......1%) among patients with sperm concentration attention....

Simulation of the WWER-440/213 maximum credible accident at the EhNITs stand

International Nuclear Information System (INIS)

Blinkov, V.N.; Melikhov, O.I.; Melikhov, V.I.; Davydov, M.V.; Sokolin, A.V.; Shchepetil'nikov, Eh.Yu.

2000-01-01

The calculations of thermohydraulic processes through the ATHLET code for determining optimal conditions for modeling the coolant leakage at the EhNITs stand by the maximum credible accident at the NPP with WWER-440/213 reactor are presented. The diameters of the nozzle at the stand, whereby the local criterion of coincidence with the data on the NPP (by the maximum flow) and integral criterion of coincidence (by the mass and energy of the coolant, effluent during 10 s) are determined in the process of parametric calculations [ru

Draft Genome Sequence of Leuconostoc mesenteroides 213M0, Isolated from Traditional Fermented Mare Milk Airag in Bulgan Aimag, Mongolia.

Science.gov (United States)

Morita, Hidetoshi; Toh, Hidehiro; Oshima, Kenshiro; Nakano, Akiyo; Hano, Chihiro; Yoshida, Saki; Bolormaa, Tsognemekh; Burenjargal, Sedkhuu; Nguyen, Co Thi Kim; Tashiro, Kosuke; Arakawa, Kensuke; Miyamoto, Taku

2016-03-31

Leuconostoc mesenteroides213M0 was isolated from traditional fermented mare milk airag in Bulgan Aimag, Mongolia. This strain produces a listericidal bacteriocin-like inhibitory substance. Here, we report the draft genome sequence of this organism. Copyright © 2016 Morita et al.

WWER 440/213 NPP containment from the point of view of IAEA requirements and current European practice

International Nuclear Information System (INIS)

Sabata, M.

2000-01-01

In principle, in a NPP three barriers are used to prevent the release of radioactive substances into the environment: the fuel cladding, the primary circuit boundary, and the containment. The presentation deals with the third barrier - the containment, and explains the philosophy of maximum design accident management in the containment of WWER-440/213 NPPs. This type of containment is shown to be an original and fully functional technical solution. Due to the use of the large reserve of the H 3 BO 3 solution and to the active spray systems, an underpressure can be quickly established, thus minimizing any impact of the accident on the environment. The capability of the bubble condenser system for a maximum design accident has been proven by analyses and by tests performed within the framework of PHARE PH 2.13/95: the condenser system can reduce the pressure in the containment in an effective way. The majority of questions arising so far have been answered and the concern resulting from insufficient verification of the system with regard to western standards has been refuted. The WWER-440/213 is fully consistent with IAEA requirements and with current European practice. (A.K.)

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Nørby, Karin Kristiane

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) of the European Food Safety Authority (EFSA) was requested to evaluate the genotoxic potential of 26 flavouring substances from subgroup 2.7 of FGE.19 in Flavouring Group Evaluation (FGE) 213. In the first v...

The R213G polymorphism in SOD3 protects against allergic airway inflammation

DEFF Research Database (Denmark)

Gaurav, Rohit; Varasteh, Jason T; Weaver, Michael R

2017-01-01

) in bronchoalveolar lavage fluid and reduced type II innate lymphoid cells (ILC2s) in lungs. SOD mimetic (Mn (III) tetrakis (N-ethylpyridinium-2-yl) porphyrin) attenuated Alternaria-induced expression of IL-33 and IL-8 release in BEAS-2B cells. These results suggest that R213G SNP potentially benefits its carriers...... by resulting in high EC-SOD in airway-lining fluid, which ameliorates allergic airway inflammation by dampening the innate immune response, including IL-33/ST2-mediated changes in ILC2s....

An investigation on thermal and friction effect produced by friction welding of SA 213 tube to SA 387 tube plate

Directory of Open Access Journals (Sweden)

S. Pandia Rajan

2016-03-01

Full Text Available The present study investigates the effect of thermal and friction produced in the tube to tube plate during the friction welding process by using a Tungsten carbide external tool. In this process, the fictional welding of SA 213 tube and SA 387 tube plate was done by using an external tool. Modeling of tool and wok piece is done by using Solid works and to study the thermal and frictional effect by using Ansys. In this research work, joining of SA 213 tube to SA 387 tube plate was done by using two different techniques such as with hole [WH] and without hole [WOH]. The stress value of with hole and without hole such as 18,782 MPa and 10,486 MPa respectively and the ultimate heat flux generated with hole and without hole such as 0.80475 W/mm2 and 1.1344 W/mm2 respectively were observed.

Adoption of in-vessel retention concept for VVER-440/V213 reactors in Central European Countries

Energy Technology Data Exchange (ETDEWEB)

Matejovic, Peter, E-mail: peter.matejovic@ivstt.sk [Inzinierska Vypoctova Spolocnost (IVS), Jana Holleho 5, 91701 Trnava (Slovakia); Barnak, Miroslav; Bachraty, Milan; Vranka, Lubomir [Inzinierska Vypoctova Spolocnost (IVS), Jana Holleho 5, 91701 Trnava (Slovakia); Berky, Robert [Integrita a Bezpecnost Ocelovych Konstrukcii, Rybnicna 40, 831 07 Bratislava (Slovakia)

2017-04-01

Highlights: • Design of in-vessel retention concept for VVER-440/V213 reactors. • Thermal loads acting on the inner reactor surface. • Structural response of reactor pressure vessel. • External reactor vessel cooling. - Abstract: An in-vessel retention (IVR) concept was proposed for standard VVER-440/V213 reactors equipped with confinement made of reinforced concrete and bubbler condenser pressure suppression system. This IVR concept is based on simple modifications of existing plant technology and thus it was attractive for plant operators in Central European Countries. Contrary to the solution that was adopted before at Loviisa NPP in Finland (two units of VVER-440/V213 reactor with steel confinement equipped with ice condenser), the coolant access to the reactor pressure vessel from flooded cavity is enabled via closable hole installed in the centre of thermal shield of the reactor lower head instead of lowering this massive structure in the case of severe accident. As a consequence, the crucial point of this IVR concept is narrow gap between torispherical lower head and thermal and biological shield. Here the highest thermal flux is expected in the case of severe accident. Thus, realistic estimation of thermal load and corresponding deformations of reactor wall and their impact on gap width for coolant flow are of primarily importance. In this contribution the attention is paid especially to the analytical support with emphasis to the following points: 1) {sup ∗}Estimation of thermal loads acting on the inner reactor surface; 2) {sup ∗}Estimation of structural response of reactor pressure vessel (RPV) with emphasis on the deformation of outer reactor surface and its impact on the annular gap between RPV wall and thermal/biological shield; 3) {sup ∗}Analysis of external reactor vessel cooling. For this purpose the ASTEC code was used for performing analysis of core degradation scenarios, the ANSYS code for structural analysis of reactor vessel

Safety improvement and results of commissioning of Mochovce NPP WWER 440/213

International Nuclear Information System (INIS)

Lipar, M.

1998-01-01

Mochovce NPP is the last one of this kind and compared to its predecessors, it is characterized by several modifications which contribute to the improvement of the safety level. In addition based on Nuclear Regulatory Authority requirements and based on documents: - IAEA - Safety Issues and their ranking for NPP WWER 440/213, - IAEA - Safety Improvement of Mochovce NPP Project Review Mission, - Riskaudit - Evaluation of the Mochovce NPP Safety Improvements. Additional safety measures have been implemented before commissioning. The consortium EUCOM (FRAMATOME - SIEMENS), SKODA Praha, ENERGOPROJEKT Praha, Russian organizations and VUJE Trnava Nuclear Power Plants research institute were selected for design and implementation of the safety measures. The papers summarized, safety requirements, safety measures implemented, results of commissioning and results of safety analysis report evaluation. (author)

An investigation on SA 213-Tube to SA 387-Tube plate using friction welding process

Energy Technology Data Exchange (ETDEWEB)

Rajan, S. Pandia; Kumaraswamidhas, L. A. [Indian Institute of Technology, Jharkhand (India); Kumaran, S. Senthil [RVS School of Engineering and Technology, Tamil Nadu (India); Muthukumaran, S. [National Institute of Technology, Tamil Nadu (India)

2016-01-15

Friction welding of tube to tube plate using an external tool (FWTPET) is a relatively newer solid state welding process used for joining tube to tube plate of either similar or dissimilar materials with enhanced mechanical and metallurgical properties. In the present study, FWTPET has been used to weld SA 213 (Grade T12) tube with SA 387 (Grade 22) tube plate. The welded samples are found to have satisfactory joint strength and the Energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) study showed that inter metallic compound is absent in the weld zone. The different weld joints have been identified and the phase composition is found using EDX and XRD. Microstructures have been analyzed using optical and Scanning electron microscopy (SEM). The mechanical properties such as hardness, compressive shear strength and peel test for different weld conditions are studied and the hardness survey revealed that there is increase in hardness at the weld interface due to grain refinement. The corrosion behavior for different weld conditions have been analyzed and the weld zone is found to have better corrosion resistance due to the influence of the grain refinement after FWTPET welding process. Hence, the present investigation is carried out to study the behavior of friction welded dissimilar joints of SA 213 tube and SA 387 tube plate joints and the results are presented. The present study confirms that a high quality tube to tube plate joint can be achieved using FWTPET process at 1120 rpm.

The crystal structure of emilite, Cu_10.7Pb_10.7Bi_21.3S₄₈, the second 45 Å derivative of the bismuthinite-aikinite solid-solution series

DEFF Research Database (Denmark)

Balic-Zunic, Tonci; Topa, Dan; Makovicky, Emil

2002-01-01

geology, emilite, Cu10.7Pb10.7Bi21.3S48, aikinite-bismuthinite derivative, crystal structure, Felbertal, scheelite deposit, Austria......geology, emilite, Cu10.7Pb10.7Bi21.3S48, aikinite-bismuthinite derivative, crystal structure, Felbertal, scheelite deposit, Austria...

Prospective Study of Neuroendoscopy versus Microscopy: 213 Cases of Microvascular Decompression for Trigeminal Neuralgia Performed by One Neurosurgeon.

Science.gov (United States)

Xiang, Hui; Wu, Guangyong; Ouyang, Jia; Liu, Ruen

2018-03-01

To compare the efficacy and complications of microvascular decompression (MVD) by complete neuroendoscopy versus microscopy for 213 cases of trigeminal neuralgia (TN). Between January 2014 and January 2016, 213 patients with TN were randomly assigned to the neuroendoscopy (n = 105) or microscopy (n = 114) group for MVD via the suboccipital retrosigmoid approach. All procedures were performed by the same neurosurgeon. Follow-up was conducted by telephone interview. Statistical data were analyzed with the chi-square test, and a probability (P) value of ≤0.05 was considered statistically significant. Chi-square test was conducted using SAS 9.4 software (SAS Institute, Cary, North Carolina, USA). There were no statistical differences between the 2 groups in pain-free condition immediately post procedure, pain-free condition 1 year post procedure, hearing loss, facial hypoesthesia, transient ataxia, aseptic meningitis, intracranial infections, and herpetic lesions of the lips. There were no instances of death, facial paralysis, cerebral hemorrhage, or cerebrospinal fluid leakage in either group. There were no significant differences in the cure rates or incidences of surgical complications between neuroendoscopic and microscopic MVD. Copyright © 2017 Elsevier Inc. All rights reserved.

PTPN13, a Fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3

Energy Technology Data Exchange (ETDEWEB)

Inazawa, Johji; Ariyama, Takeshi; Abe, Tatsuo [Kyoto Prefectural Univ. of Medicine (Japan)] [and others

1996-01-15

PTPN13 is a protein tyrosine phosphatase that associates with the C-terminal negative regulatory domain in the Fas (APO-1/CD95) receptor. The PTPN13 protein contains six GLGF repeats that have been found in the rat postsynaptic density protein (PSD-95) and the Drosophila tumor suppressor protein, lethal-(1)-disclarge-1 (dlg-1). The localization of the PTPN13 gene to human chromosome 4q21.3 was determined by both FISH and PCR analysis of somatic cell hybrids. This 4q21.3 chromosomal region contains a gene for autosomal dominant polycystic kidney disease as well as the region frequently deleted in liver and ovarian cancers, suggesting that PTPN13 is a candidate for one of the putative tumor suppressor genes on the long arm of chromosome 4. 21 refs., 1 fig.

Corrosión por depósitos salinos de los aceros SA213-T22 y SA213-TP347H en presencia de una mezcla 80%V2O5-20%Na2SO4-20%Na2SO4

Directory of Open Access Journals (Sweden)

Romero, M. A.

1998-02-01

Full Text Available Many hot corrosion problems in industrial and utility boilers are caused by molten salts. The corrosion processes which occur in salts are of an electrochemical nature, and so they can be studied using electrochemical test methods. In this research, electrochemical techniques in molten salt systems have been used for the measurements of molten corrosion processes. Electrochemical test methods are described here for a salt mixture of 80%V2O5-20%Na2SO4 at 540-680°C. To establish better the electrochemical corrosion rate mearurements for molten salt systems, information from electrochemical potentiodynamic polarization curves, such as polarization resistance and Tafel slopes were used in this study to generate corrosion rate data. The salt was contained in a quartz crucible inside a stainless steel retort. The atmosphere used was air. A thermocouple sheathed with quartz glass was introduced into the molten salt for temperature monitoring and control. Two materials were tested in the molten mixture: SA213-T22 and SA213-TP347H steels. The corrosion rates values obtained using electrochemical methods were around 0.58-7.14 mm/yr (22.9-281 mpy. The corrosion rate increase with time.Muchos problemas de corrosión por depósitos salinos en la industria eléctrica, especialmente en los generadores de vapor, se deben al ataque por sales fundidas. El proceso de corrosión en sales fundidas es de naturaleza electroquímica; así, puede estudiarse empleando técnicas electroquímicas. Este proceso de corrosión en un sistema de sales fundidas, mezcla de 80%V2O5 y 20%Na2SO4 a temperaturas comprendidas entre 540 y 680°C, se evaluó en esta investigación por medio de técnicas electroquímicas. Para medir la velocidad de corrosión por depósitos salinos se parte de curvas de polarización potenciodinámicas determinando la resistencia de polarización por extrapolación de las pendientes de Tafel. Las sales se fundieron en un crisol de cuarzo dentro de un

The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine

NARCIS (Netherlands)

Hottenga, J. J.; Vanmolkot, K. R. J.; Kors, E. E.; Kheradmand Kia, S.; de Jong, P. T. V. M.; Haan, J.; Terwindt, G. M.; Frants, R. R.; Ferrari, M. D.; van den Maagdenberg, A. M. J. M.

2005-01-01

Previously, we described a large Dutch family with hereditary vascular retinopathy (HVR), Raynaud's phenomenon and migraine. A locus for HVR was mapped on chromosome 3p21.1-p21.3, but the gene has not yet been identified. The fact that all three disorders share a vascular aetiology prompted us to

Characteristics of the NE-213 large-volume neutron counters for muon catalyzed fusion investigation

International Nuclear Information System (INIS)

Bystritsky, V.M.; Wozniak, J.; Zinov, V.G.

1984-01-01

The Monte-Carlo method was used to establish the properties and feasibility of a large-volume NE-213 scin illator as an efficient neutron detector. The recoil proton spectra, calculated efficiencies for different detection thresholds and scintillator sizes are presented for the neutron energy up to 15 MeV. The time characteristics, e. g., time resolution, are discussed. It is also shown that no strong influence of light attenuation by the scintilla or itself on calculated efficiencies is observed, when gamma-calibration technique is used. The detector vol me of approximately 100 l is suggested for application in investigations of μ-atom and μ-molecular processes

On the Use of an ER-213 Detonator to Establish a Baseline for the ER-486

Energy Technology Data Exchange (ETDEWEB)

Thomas, Keith A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Liechty, Gary H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jaramillo, Dennis C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Munger, Alan C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); McHugh, Douglas C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kennedy, James E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2014-08-19

This report documents a series of tests using a TSD-115 fireset coupled with an ER-213, a gold exploding bridgewire (EBW) detonator. These tests were designed to fire this EBW with a smaller fireset to obtain current and voltage data as well as timing information at voltage levels below, above, and throughout the threshold firing region. This study could then create a database for comparison to our current ER-486 EBW development, which is designed to be a lower voltage (<500V) device.

Comparative Performance of Rear Facing Child Restraint Systems on the CMVSS 213 Bench and Vehicle Seats

Science.gov (United States)

Tylko, Suzanne; Locey, Caitlin M.; Garcia-Espana, J. Felipe; Arbogast, Kristy B.; Maltese, Matthew R.

2013-01-01

The purpose of this study was to compare the dynamic response of rear-facing child restraint systems (RFCRS) installed on the CMVSS 213 sled bench and a selection of vehicle seats. Thirty-six sled tests were conducted: three models of rear facing CRS with an anthropomorphic test device (ATD) representing a 12 month old child (CRABI) were affixed via lower anchors (LATCH), 3 point belt without CRS base, and 3 point belt with CRS base to one of three vehicle seats or the CMVSS 213 bench seat. All CRS were subjected to an identical sled acceleration pulse. Two types of matched pair analysis: “bench-to-vehicle” and “method of attachment” were conducted. Statistically significant differences were observed in the kinematic responses of the ATD and the CRS. This is the first study to quantify differences between the regulatory bench and vehicle seats on a system level and evaluate the influence of attachment method. Our results show that the difference in RFCRS forward excursion between 3-point belt with base and LATCH installations was between 1 and 7 percent on the bench and 22 to 76 percent on the vehicle seats. When evaluating the dynamic performance of RFCRS, the use of real vehicle seats from vehicles that commonly carry children may provide valuable insight. The findings would require further confirmation using a broader selection of RFCRS and vehicle seats, before generalizable conclusions can be drawn. PMID:24406967

Assignment of the gene for human tetranectin (TNA) to chromosome 3p22-->p21.3 by somatic cell hybrid mapping

DEFF Research Database (Denmark)

Durkin, M E; Naylor, S L; Albrechtsen, R

1997-01-01

Tetranectin is a plasminogen-binding protein that is induced during the mineralization phase of osteogenesis. By screening a human chromosome 3 somatic cell hybrid mapping panel, we have localized the human tetranectin gene (TNA) to 3p22-->p21.3, which is distinct from the loci of two human...

Experimental support of the bleed and feed accident management measures for VVER-440/213 type reactors

International Nuclear Information System (INIS)

Szabados, L.

2002-01-01

In the original design of the VVER-440/213 type nuclear power plants event oriented emergency operating procedures (EOP) were implemented. In the last years, however, new symptom based procedures of Westinghouse-type have been developed and partly implemented for the plants in Central Europe including the Paks Nuclear Power Plant. Paper gives a short review of the experiments performed in the PMK-2 facility to study the effectiveness of the bleed and feed strategies and to get experimental data bases for the validation of thermohydraulic system codes like RELAP5, ATHLET and CATHARE.(author)

Seismic margin assessment and earthquake experience based methods for WWER-440/213 type NPPs

International Nuclear Information System (INIS)

Masopust, R.

1996-01-01

This report covers the review of the already completed studies, namely, safe shutdown system identification and classification for Bohunice NPP and the comparative study of standards and criteria. It contains a report on currently ongoing studies concerning seismic margin assessment and earthquake experience based methods in application for seismic evaluation and verification of structures and equipment components of the operating WWER-440/213 type NPPs. This is based on experiences obtained from Paks NPP. The work plan for the remaining period of Benchmark CRP and the new proposals are included. These are concerned with seismic evaluation of selected safety related mechanical equipment and pipes of Paks NPP, and the actual seismic issues of the Temelin WWER-1000 type NPP

The rs10757278 Polymorphism of the 9p21.3 Locus in Children with Arterial Ischemic Stroke: A Family-Based and Case-Control Study.

Science.gov (United States)

Niemiec, Pawel; Balcerzyk, Anna; Iwanicki, Tomasz; Emich-Widera, Ewa; Kopyta, Ilona; Nowak, Tomasz; Pilarska, Ewa; Pienczk-Ręcławowicz, Karolina; Kaciński, Marek; Wendorff, Janusz; Gorczynska-Kosiorz, Sylwia; Trautsolt, Wanda; Grzeszczak, Władysław; Zak, Iwona

2017-12-01

The association of 9p21.3 locus single nucleotide polymorphisms with arterial ischemic stroke in adults was demonstrated in many studies, but there are no studies in pediatric arterial ischemic stroke patients. We investigated whether the 9p21.3 locus polymorphism, namely rs10757278, is associated with the arterial ischemic stroke risk in children. The study group consisted of 335 individuals: 80 children with arterial ischemic stroke, their biological parents (n = 122), and 133 children (age and sex matched) without any symptoms of arterial ischemic stroke as a control group. The rs10757278 polymorphism was genotyped using the TaqMan® Pre-designed SNP Genotyping Assay (Applied Biosystems). Two different study design models were used: family-based association test (transmission-disequilibrium test) and case-control model. There were no statistically significant differences in the distribution of genotypes and alleles of the rs10757278 polymorphism between groups of children with arterial ischemic stroke and controls. The frequency of both transmitted alleles in transmission-disequilibrium test analysis was identical (50%). The A allele carrier state (AA+AG genotype) was more frequent in arterial ischemic stroke children with hemiparesis than in patients without this symptom (94.5% versus 68.0%, P = .004). There is no evidence to consider the 9p21.3 locus polymorphism as a risk factor for childhood arterial ischemic stroke. Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Meson-Exchange Enhancement of First-Forbidden $\\beta$-Transitions in the Lead Region

CERN Multimedia

Delaure, B J P; Severijns, N

2002-01-01

Both on-line and off-line low temperature nuclear orientation is used to measure the $\\beta$-asymmetry parameter for the first-forbidden g.s. $\\rightarrow$~g.s. $\\beta$-transitions of $^{205}$Hg, $^{207,209}$Tl, $^{209}$Pb and $^{213}$Bi. From this, the ratio of the rank-zero and the rank-one strengths in these decays can be deduced, with the rank of a $\\beta$-transition being defined as the total angular momentum of the lepton system. Combining this result with the experimental ${ft}$-values yields for the first time a purely experimental determination of the rank-zero contribution in these $\\Delta$ J = 0 first-forbidden transitions. This provides an independent check of the large enhancement (of about 100% over the impulse approximation) of the rank-zero matrix element of $\\gamma_{5} $, caused by meson exchange currents (MEC), which was recently obtained from a comparison of calculated first-forbidden $\\beta$-decay rates with experimentally observed values for nuclei in the lead region (A = 205-212). Measur...

Charged particle identification including Pions by pulse-shape discrimination with an NE213 liquid scintillator

International Nuclear Information System (INIS)

Nakamoto, T.; Ishibashi, K.; Matsufuji, N.; Shigyo, N.; Maehata, K.

1995-01-01

Particles emitted from spallation reactions induced by protons having GeV energies were measured with an NE213 liquid scintillator, 12.7 cm in diameter and 12.7 cm thick. The pulse-shape discrimination (PSD) was carried out for charged particle identification by the two-gate integration method. Pions having energies up to 60 MeV were clearly discriminated from protons and electrons. On the contrary, pions with higher energies could not be identified since they escaped from the detector. The advantage of PSD for charged particle identification is that there is no requirement for a ΔE detector in the measurements. copyright 1995 American Institute of Physics

Neuropathic pain in patients with spinal cord injury: report of 213 patients.

Science.gov (United States)

Teixeira, Manoel Jacobsen; Paiva, Wellingson Silva; Assis, Maruska Salles; Fonoff, Erich Talamoni; Bor-Seng-Shu, Edson; Cecon, Angelo Daros

2013-09-01

Management of neuropathic pain following spinal cord injury (SCI) can be a frustrating experience for patients since it poses a therapeutic challenge. In this article the authors describe the clinical characteristics of a group of patients with pain after spinal cord injury. In this retrospective study, 213 patients with SCI and neuropathic pain were assessed. We analyzed clinical characteristics, treatment options, and pain intensity for these patients. The main cause of SCI was spine trauma, which occurred in 169 patients, followed by tumors and infection. Complete lesions were verified in 144 patients. In our study, patients with traumatic SCI and partial lesions seem to be presented with more intense pain; however, this was not statistically significant. Neuropathic pain is a common complaint in patients with SCI and presents a treatment challenge. Knowledge of the clinical characteristics of this group of patients may help determine the best approach to intervention.

In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage

International Nuclear Information System (INIS)

Vandenbulcke, Katia; Lahorte, Christophe; Slegers, Guido; De Vos, Filip; Dierckx, Rudi A.; Offner, Fritz; Philippe, Jan; Apostolidis, Christos; Molinet, Roger; Nikula, Tuomo K.; Bacher, Klaus; De Gelder, Virginie; Vral, Anne; Thierens, Hubert

2003-01-01

External source radiotherapy and beta radioimmunotherapy (RIT) are effective treatments for lymphoid malignancies. The development of RIT with alpha emitters is attractive because of the high linear energy transfer (LET) and short path length, allowing higher tumour cell kill and lower toxicity to healthy tissues. We assessed the relative biological efficacy (RBE) of alpha RIT (in vitro) compared to external gamma irradiation with respect to induction of apoptosis in B chronic lymphocytic leukaemia (B-CLL) and induction of chromosomal damage in healthy donor B and T lymphocytes. The latter was measured by a micronucleus assay. 213 Bi was eluted from a 225 Ac generator and conjugated to CD20 antibody (rituximab) with CHX-A''-DTPA as a chelator. B-CLL cells from five patients were cultured for 24 h in RPMI/10% FCS while exposed to 213 Bi conjugated to CD20 antibody or after external 60 Co gamma irradiation. Binding assays were performed in samples of all patients to calculate the total absorbed dose. Apoptosis was scored by flow cytometric analyses of the cells stained with annexin V-FITC and 7-AAD. Apoptosis was expressed as % excess over spontaneous apoptosis in control. Full dose range experiments demonstrated 213 Bi-conjugated CD20 antibody to be more effective than equivalent doses of external gamma irradiation, but showed that similar plateau values were reached at 10 Gy. The RBE for induction of apoptosis in B-CLL was 2 between 1.5 and 7 Gy. The micronucleus yield in lymphocytes of healthy volunteers was measured to assess the late toxicity caused by induction of chromosomal instability. While gamma radiation induced a steady increase in micronucleus yields in B and T cells, the damage induced by 213 Bi was more dramatic, with RBE ranging from 5 to 2 between 0.1 Gy and 2 Gy respectively. In contrast to gamma irradiation, 213 Bi inhibited mitogen-stimulated mitosis almost completely at 2 Gy. In conclusion, high-LET targeted alpha particle exposure killed B

Neuropathic pain in patients with spinal cord injury: report of 213 patients

Directory of Open Access Journals (Sweden)

Manoel Jacobsen Teixeira

2013-09-01

Full Text Available Objective Management of neuropathic pain following spinal cord injury (SCI can be a frustrating experience for patients since it poses a therapeutic challenge. In this article the authors describe the clinical characteristics of a group of patients with pain after spinal cord injury. Methods In this retrospective study, 213 patients with SCI and neuropathic pain were assessed. We analyzed clinical characteristics, treatment options, and pain intensity for these patients. Results The main cause of SCI was spine trauma, which occurred in 169 patients, followed by tumors and infection. Complete lesions were verified in 144 patients. In our study, patients with traumatic SCI and partial lesions seem to be presented with more intense pain; however, this was not statistically significant. Conclusions Neuropathic pain is a common complaint in patients with SCI and presents a treatment challenge. Knowledge of the clinical characteristics of this group of patients may help determine the best approach to intervention.

Identification of a common microdeletion cluster in 7q21.3 subband among patients with myeloid leukemia and myelodysplastic syndrome

Energy Technology Data Exchange (ETDEWEB)

Asou, Hiroya; Matsui, Hirotaka; Ozaki, Yuko; Nagamachi, Akiko; Nakamura, Megumi; Aki, Daisuke [Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553 (Japan); Inaba, Toshiya, E-mail: tinaba@hiroshima-u.ac.jp [Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553 (Japan)

2009-05-29

Monosomy 7 and interstitial deletions in the long arm of chromosome 7 (-7/7q-) is a common nonrandom chromosomal abnormality found frequently in myeloid disorders including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and juvenile myelomonocytic leukemia (JMML). Using a short probe-based microarray comparative genomic hybridization (mCGH) technology, we identified a common microdeletion cluster in 7q21.3 subband, which is adjacent to 'hot deletion region' thus far identified by conventional methods. This common microdeletion cluster contains three poorly characterized genes; Samd9, Samd9L, and a putative gene LOC253012, which we named Miki. Gene copy number assessment of three genes by real-time PCR revealed heterozygous deletion of these three genes in adult patients with AML and MDS at high frequency, in addition to JMML patients. Miki locates to mitotic spindles and centrosomes and downregulation of Miki by RNA interference induced abnormalities in mitosis and nuclear morphology, similar to myelodysplasia. In addition, a recent report indicated Samd9 as a tumor suppressor. These findings indicate the usefulness of the short probe-based CGH to detect microdeletions. The three genes located to 7q21.3 would be candidates for myeloid tumor-suppressor genes on 7q.

Detection and Analytical Capabilities for Trace Level of Carbon in High-Purity Metals by Laser-Induced Breakdown Spectroscopy with a Frequency Quintupled 213 nm Nd:YAG Laser

Directory of Open Access Journals (Sweden)

Masaki Ohata

2017-01-01

Full Text Available The laser-induced breakdown spectroscopy (LIBS with a frequency quintupled 213 nm Nd:YAG laser was examined to the analysis of trace level of carbon (C in high-purity metals and its detection and analytical capabilities were evaluated. Though C signal in a wavelength of 247.9 nm, which showed the highest sensitivity of C, could be obtained from Cd, Ti, and Zn ca. 7000 mg kg−1 C in Fe could not be detected due to the interferences from a lot of Fe spectra. Alternative C signal in a wavelength of 193.1 nm could not be also detected from Fe due to the insufficient laser output energy of the frequency quintupled 213 nm Nd:YAG laser. The depth analysis of C by LIBS was also demonstrated and the C in Cd and Zn was found to be contaminated in only surface area whereas the C in Ti was distributed in bulk. From these results, the frequency quintupled 213 nm Nd:YAG laser, which was adopted widely as a commercial laser ablation (LA system coupled with inductively coupled plasma mass spectrometry (ICPMS for trace element analysis in solid materials, could be used for C analysis to achieve simultaneous measurements for both C and trace elements in metals by LIBS and LA-ICPMS, respectively.

Field demonstration of age dependent increase in lead phytoextraction by Pelargonium cultivar

Science.gov (United States)

Shahid, Muhammad; Arshad, Muhammad; Pinelli, Eric; Alric, Alain; Kaemmerer, Michel; Pradere, Philippe; Dumat, Camille

2013-04-01

Unnecessary for living organisms, lead (Pb) is one of the major widespread toxic metals found in the environment with potential danger to human health and to ecosystems (Shahid et al. 2012). Lead is known to induce a broad range of toxic effects to living organism, including those that are morphological, physiological and biochemical in origin (Pourrut et al. 2011). A field study was carried out in the vicinity of Pb recycling plant near Toulouse-France, and contaminated by atmospheric fallouts to evaluate lead extraction and uptake efficiency of hyperaccumulater Attar of Roses Pelargonium cultivar. It was found that Attar of Roses has ability to accumulate (8644 mgPb/kg DW plant) and survive on highly contaminated acidic soil (39250 mg kg-1 of total Pb) without any morpho-phytotoxicity symptoms. Moreover Attar showed increased extraction of lead from bulk soil to rhizosphere through Pb mobilization and ultimately increased uptake by roots and translocation to shoots. The studied contaminated soil could be cleaned up in few years by planting hyperaccumulater Attar of Rose for longer time period. Under optimum fertlization, irrigation and use of natural or synthetic chelates (EDTA, LMOWA, humic substances etc.) along with old Attar of rose plants, time requires for complete remediation of contaminated site can be reduced to practically applicable time period. Moreover, the use of Pelargonium for remediation has several additional practical, esthetical and economic advantages. The extraction of value-added essential oils from harvested biomass could offset the cost of deploying phytoremediation and renders it as a viable approach for remediating highly contaminated soils, on large scale. Keywords: metal uptake, Pelargonium, phytoremediation, cultivar, soil-plant transfer and kinetic. References Pourrut, B., Shahid, M., Dumat, C., Winterton, P., Pinelli, E., 2011a. Lead uptake, toxicity and detoxification in plants. Rev. Environ. Contam. Toxicol. 213, 113-136. Shahid

A novel description of a syndrome consisting of 7q21.3 deletion including DYNC1I1 with preserved DLX5/6 without ectrodactyly: a case report.

Science.gov (United States)

Ramos-Zaldívar, Héctor M; Martínez-Irías, Daniel G; Espinoza-Moreno, Nelson A; Napky-Rajo, José S; Bueso-Aguilar, Tulio A; Reyes-Perdomo, Karla G; Montes-Gambarelli, Jimena A; Euceda, Isis M; Ponce-Barahona, Aldo F; Gámez-Fernández, Carlos A; Moncada-Arita, Wilberg A; Palomo-Bermúdez, Victoria A; Jiménez-Faraj, Julia E; Hernández-Padilla, Amanda G; Olivera, Denys A; Robertson, Kevin J; Leiva-Sanchez, Luis A; Herrera-Paz, Edwin Francisco

2016-06-13

Chromosomal region 7q21.3 comprises approximately 5.2 mega base pairs that include genes DLX5/6, SHFM1, and DYNC1I1 associated with split hand/split foot malformation 1. So far, there are reports of eight families with deletion of DYNC1I1 and preserved DLX5/6 associated with ectrodactyly. From these families, only three patients did not present ectrodactyly and, unlike our patient, no other cases have been described as having craniofacial dysmorphology, mitral valve prolapse, kyphoscoliosis, inguinal herniae, or personality disorder. There is no designation described in the literature for patients with syndromic manifestations without ectrodactyly, which hinders diagnosis. We report the case of a 44-year-old mestizo (combined European and Amerindian descent) man with a 3191 kilo base pairs deletion and International System for Human Cytogenetic Nomenclature array 7q21.3 (93,389,222-96,579,845)x1. Clinical manifestations included micrognathia, retrognathia, wormian bones, auditory canal stenosis, depressed nasal bridge, epicanthal fold, fullness of upper eyelid, long philtrum, low-set ears, sensorineural hearing loss, kyphoscoliosis, bilateral inguinal herniae, mild mitral valve prolapse, and paranoid personality disorder. His isolated DNA was analyzed using a CytoScan HD Microarray system. Chromosome Analysis Suite software was utilized for the microarray analysis. All copy number changes were determined using the human genome build 19 (hg19/NCBI build 37). Cases of deletions within chromosome 7q21.3 that include the split hand/split foot malformation 1 region represent a diagnostic challenge when not presenting ectrodactyly despite being syndromic. Due to the heterogeneity of the region, a better method to group and classify these patients is needed to facilitate their clinical diagnosis. For this purpose, we suggest that patients with 7q21.3 deletion including DYNC1I1 and preserved DLX5/6 without ectrodactyly, accompanied by craniofacial dysmorphology

Living PSA program for VVER 440/213 in the Czech Republic

International Nuclear Information System (INIS)

Husak, S.; Patrik, M.

2000-01-01

The paper presents an overview of a Living PSA concept in the Czech Republic for the VVER 440/213 NPP Dukovany unit. The first step of PSA program was a Level 1 basic study for Unit No. 1 which was completed in 1995. The main objective of the study was to determine the risk level of full power operation and its contributors as well as to reveal the weak points of the plant. Living PSA program for a Level 1 study has been afterwards established as a framework for all activities related to risk assessment and risk based decision-making support in NPP Dukovany. The basic parts of the project are: a management of PSA models and studies to implement design and procedures, modifications or new data inputs from data collection; continuous improvement based of new analyses, experiments or more detailed models; an extensions of the scope (external events, all plant operating modes, other sources of radioactive releases). The Living PSA program in NPP Dukovany provides basis for three kinds of PSA activities: risk assessment applications, risk monitoring and risk assessment of operational. (author)

The AtRAD21.1 and AtRAD21.3 Arabidopsis cohesins play a synergistic role in somatic DNA double strand break damage repair

Czech Academy of Sciences Publication Activity Database

da Costa-Nunes, J.A.; Capitao, C.; Kozák, Jaroslav; Costa-Nunes, P.; Ducasa, G.M.; Pontes, O.; Angelis, Karel

2014-01-01

Roč. 14, DEC 16 2014 (2014) ISSN 1471-2229 R&D Projects: GA MŠk(CZ) LD13006; GA ČR GA13-06595S Institutional support: RVO:61389030 Keywords : Arabidopsis * AtRAD21.1 * AtRAD21.3 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.813, year: 2014

In vitro evaluation of {sup 213}Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage

Energy Technology Data Exchange (ETDEWEB)

Vandenbulcke, Katia; Lahorte, Christophe; Slegers, Guido [Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000, Gent (Belgium); De Vos, Filip; Dierckx, Rudi A. [Division of Nuclear Medicine, Ghent University Hospital (Belgium); Offner, Fritz [Department of Hematology, Ghent University Hospital (Belgium); Philippe, Jan [Department of Clinical Chemistry, Ghent University Hospital (Belgium); Apostolidis, Christos; Molinet, Roger; Nikula, Tuomo K. [European Commission, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe (Germany); Bacher, Klaus; De Gelder, Virginie; Vral, Anne; Thierens, Hubert [Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University (Belgium)

2003-10-01

External source radiotherapy and beta radioimmunotherapy (RIT) are effective treatments for lymphoid malignancies. The development of RIT with alpha emitters is attractive because of the high linear energy transfer (LET) and short path length, allowing higher tumour cell kill and lower toxicity to healthy tissues. We assessed the relative biological efficacy (RBE) of alpha RIT (in vitro) compared to external gamma irradiation with respect to induction of apoptosis in B chronic lymphocytic leukaemia (B-CLL) and induction of chromosomal damage in healthy donor B and T lymphocytes. The latter was measured by a micronucleus assay. {sup 213}Bi was eluted from a {sup 225}Ac generator and conjugated to CD20 antibody (rituximab) with CHX-A''-DTPA as a chelator. B-CLL cells from five patients were cultured for 24 h in RPMI/10% FCS while exposed to {sup 213}Bi conjugated to CD20 antibody or after external {sup 60}Co gamma irradiation. Binding assays were performed in samples of all patients to calculate the total absorbed dose. Apoptosis was scored by flow cytometric analyses of the cells stained with annexin V-FITC and 7-AAD. Apoptosis was expressed as % excess over spontaneous apoptosis in control. Full dose range experiments demonstrated {sup 213}Bi-conjugated CD20 antibody to be more effective than equivalent doses of external gamma irradiation, but showed that similar plateau values were reached at 10 Gy. The RBE for induction of apoptosis in B-CLL was 2 between 1.5 and 7 Gy. The micronucleus yield in lymphocytes of healthy volunteers was measured to assess the late toxicity caused by induction of chromosomal instability. While gamma radiation induced a steady increase in micronucleus yields in B and T cells, the damage induced by {sup 213}Bi was more dramatic, with RBE ranging from 5 to 2 between 0.1 Gy and 2 Gy respectively. In contrast to gamma irradiation, {sup 213}Bi inhibited mitogen-stimulated mitosis almost completely at 2 Gy. In conclusion, high

Requirements and possible upgrading concept for the WWER-440/213: Mochovce NPP structures under seismic conditions

International Nuclear Information System (INIS)

Freiman, M.

1993-01-01

The Mochovce-Nuclear Power Plant is one of the WWER-440/213 plants which has been designed against earthquake. Nevertheless, the design earthquake has not been assessed adequately to the seismic hazard at the site. A new seismic design shall include an increased seismic input and assure an acceptable standard of safety. This contribution is related to some design aspects of civil structures for this nearly finished plant, such as: existing design and its margins with regard to the employed codes; requirements for a new design concept; effects to be expected by an increased design earthquake; applicable design methods; use of inelastic design spectra, behavior factors and capacity design; feasible upgrading measures. (author)

Fabrication and charge/energy-transfer study of 4,7-bis(4-triphenylamino)benzo- 2,1,3-thiadiazole/CuPc composite films

International Nuclear Information System (INIS)

Zhu Yuanyuan; Wei Xiao; Xue Minzhao; Zhang Qing; Sheng Qiaorong; Liu Yangang; Gu Shuangxi

2010-01-01

Composite films of 4,7-bis(4-triphenylamino)benzo-2,1,3-thiadiazole (TBT) and copper phthalocyanine (CuPc) are fabricated via protonation-coelectrophoretic deposition from nitromethane solutions of TBT/CuPc mixture in the presence of trifluoroacetic acid as a protonation reagent. A nanospheres-nanowires interpenetrating network structure is obtained when the molar percentage of TBT is 70%. Furthermore, the existence of TBT makes α-phased CuPc be partly transformed into the β-phase, and simultaneously, CuPc disorganizes the TBT unit cells. The blue shift on the absorption edge of TBT and the significant fluorescence quenching in the composite films indicate energy/charge transfer and donor-acceptor (D-A) heterojunction formation. Then these results are proved from another point of view: the mutual overlap of absorption and emission spectra of TBT and CuPc lead to a bidirectional Foerster resonance energy transfer at the interface; the molecular energy levels calculated from the results of cyclic voltammetry theoretically determine that there exist a D-A heterojunction and charge transfer from TBT to CuPc. Finally, from the investigation of the field-induced surface photovoltage spectra, it can be concluded that this charge transfer results in efficient dissociation of the photoinduced excitons in the composite films, followed by the generation of a strong photovoltage response.

Fabrication and charge/energy-transfer study of 4,7-bis(4-triphenylamino)benzo- 2,1,3-thiadiazole/CuPc composite films

Energy Technology Data Exchange (ETDEWEB)

Zhu Yuanyuan; Wei Xiao; Xue Minzhao; Zhang Qing; Sheng Qiaorong; Liu Yangang [School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240 (China); Gu Shuangxi, E-mail: mzxue@sjtu.edu.c [Department of Chemistry, Fudan University, Shanghai 200433 (China)

2010-12-15

Composite films of 4,7-bis(4-triphenylamino)benzo-2,1,3-thiadiazole (TBT) and copper phthalocyanine (CuPc) are fabricated via protonation-coelectrophoretic deposition from nitromethane solutions of TBT/CuPc mixture in the presence of trifluoroacetic acid as a protonation reagent. A nanospheres-nanowires interpenetrating network structure is obtained when the molar percentage of TBT is 70%. Furthermore, the existence of TBT makes {alpha}-phased CuPc be partly transformed into the {beta}-phase, and simultaneously, CuPc disorganizes the TBT unit cells. The blue shift on the absorption edge of TBT and the significant fluorescence quenching in the composite films indicate energy/charge transfer and donor-acceptor (D-A) heterojunction formation. Then these results are proved from another point of view: the mutual overlap of absorption and emission spectra of TBT and CuPc lead to a bidirectional Foerster resonance energy transfer at the interface; the molecular energy levels calculated from the results of cyclic voltammetry theoretically determine that there exist a D-A heterojunction and charge transfer from TBT to CuPc. Finally, from the investigation of the field-induced surface photovoltage spectra, it can be concluded that this charge transfer results in efficient dissociation of the photoinduced excitons in the composite films, followed by the generation of a strong photovoltage response.

Study of n-γ discrimination with NE213 and BC501A liquid scintillators of different size

International Nuclear Information System (INIS)

Moszynski, M.; Costa, G.J.; Guillaume, G.; Heusch, B.; Huck, A.; Mouatassim, S.

1994-01-01

A comparative study of n-γ discrimination by the digital charge comparison method was carried out for NE213 and BC501A scintillators of different size coupled to a 130 mm diameter XP4512B photomultiplier. Particularly, the scintillators of diameter 50 mmx50 mm size are compared with those of 4 l volume (160 mm in diameter and 200 mm in depth). The figure of merit, M, of 3.81 measured with the diameter 50 mmx50 mm BC501A scintillator at 1 MeV energy lost by recoil electrons, is much better than M of 2.05 as observed with the 4 l volume cell. This is the effect of the reduced photoelectron yield by about 50% determined for the 4 l volume scintillator. Moreover, the slowing down of the light pulse and multiscattering of neutrons have a further influence on the lowering of the M factor. The study of the M factor versus the initial delay and width of the gate set at the slow component showed that the early light of the slow component represented often by the intermediate component with the decay time constant of about 30 ns is of great importance for the n-γ discrimination. Particularly, for the 4 l volume cells it is sufficient to limit the width of the gate at the slow component to about 300 ns. The comparison of the NE213 and BC501A scintillators showed that the BC501A scintillator exhibits a larger light yield evidently observed for the 4 l volume cell and thus giving a better n-γ discrimination. ((orig.))

Upgrade the startup test instrumentation (ANMS) with innovated I and C system at the Dukovany WWER 440/213 units

International Nuclear Information System (INIS)

Kocek, V.

2005-01-01

The paper focuses on the innovation procedures of physics startup tests instrumentation used in Dukovany NPP (ANMS) connected with I and C system refurbishment of the Dukovany WWER 440/213 units. The following matters are further discussed in this paper: a) changes in ANMS design, whose has been carried out due to reflect the situation connected with I and C innovation; b) process of consistency checking during implementation stage; c) results of the physics startup tests with upgraded ANMS in 2005 (introduction of Gd2 fuel on Dukovany NPP) (Authors)

UHF-plasma torch emission spectrometry for cadmium, lead and zinc by vaporization introduction

International Nuclear Information System (INIS)

Nakashima, Ryozo

1978-01-01

As the introduction technique of aerosol into the plasma torch, vaporization introduction of metals was studied. An aliquot of metal nitrates was pipetted in a graphite crucible and dried with a vacuum pump. The dried sample was heated in a high-frequency induction furnace under inert gas carrier such as argon or nitrogen (reduction introduction). Chlorination introduction with hydrogen chloride was also studied. High-purity grade of argon, nitrogen and hydrogen chloride was used as carrier. Intensities were based on the peak area of intensity-time curves at 228.8 nm (cadmium), 405.8 nm (lead), and 213.9 nm (zinc). In the reduction introduction, the minimum temperatures to attain a constant peak area, which means a complete vaporization were 700 0 C (cadmium), 1500 0 C (lead), and 1100 0 C (zinc), respectively. In the chlorination, this temperature was 500 0 C (cadmium), 700 0 C (lead), and 300 0 C (zinc) respectively. For two introduction techniques, the latter was more sensitive than the former for cadmium and zinc, while the former was more sensitive for lead. The optimum temperature, detection limits, and the coefficients of variance calculated from the measurements of 1.0 μg of metals were as follows: Cadmium: chlorination at 850 0 C, D.L. 5ng, C.V. 10%. Lead: reduction at 1600 0 C, D.L. 10ng, C.V. 15%. Zinc: chlorination at 850 0 C, D.L. 5ng, C.V. 9%. Linear calibration lines having 45 0 slope at log-log plots, were obtained over the range from 0.05 to 6 μg for cadmium and zinc, 0.06 to 6 μg for lead on the conditions above. These techniques were also applied for analyses of biological materials for three metals without prior separations. Although the sensitivity of the chlorination introduction technique for lead was rather poor compared with that of reduction technique, the chlorination technique was applied to minimize the introduction of coexisting materials such as alkali and alkaline earth metals. The analytical results agreed reasonably with the

Scanning vs. single spot laser ablation (λ=213 nm) inductively coupled plasma mass spectrometry

International Nuclear Information System (INIS)

Gonzalez, Jhanis J.; Fernandez, Alberto; Mao Xianglei; Russo, Richard E.

2004-01-01

Sampling strategy is defined in this work as the interaction of a repetitively pulsed laser beam with a fixed position on a sample (single spot) or with a moving sample (scan). Analytical performance of these sampling strategies was compared by using 213 nm laser ablation ICP-MS. A geological rock (Tuff) was quantitatively analyzed based on NIST series 610-616 glass standard reference materials. Laser ablation data were compared to ICP-MS analysis of the dissolved samples. The scan strategy (50 μm/s) produced a flat, steady temporal ICP-MS response whereas the single spot strategy produced a signal that decayed with time (after 60 s). Single-spot sampling provided better accuracy and precision than the scan strategy when the first 15 s of the sampling time was eliminated from the data analysis. In addition, the single spot strategy showed less matrix dependence among the four NIST glasses

Response-function measurement of an NE213 scintillator using the [sup 2]H(d, n)[sup 3]He reaction

Energy Technology Data Exchange (ETDEWEB)

Aksoy, A. (Energy Research Lab., King Fahd Univ. of Petroleum and Minerals, Dhahran (Saudi Arabia)); Coban, A. (Energy Research Lab., King Fahd Univ. of Petroleum and Minerals, Dhahran (Saudi Arabia)); Naqvi, A.A. (Energy Research Lab., King Fahd Univ. of Petroleum and Minerals, Dhahran (Saudi Arabia)); Khiari, F.Z. (Energy Research Lab., King Fahd Univ. of Petroleum and Minerals, Dhahran (Saudi Arabia)); Hanly, J.M. (Duke Univ., Nuclear Labs., Durham, NC (United States)); Howell, C.R. (Duke Univ., Nuclear Labs., Durham, NC (United States)); Tornow, W. (Duke Univ., Nuclear Labs., Durham, NC (United States)); Felsher, P.D. (Duke Univ., Nuclear Labs., Durham, NC (United States)); Al-Ohali, M.A. (Duke Univ., Nuclear Labs., Durham, NC (United States)); Walter, R.L. (Duke Univ., Nuclear Labs., Durham, NC (United States))

1994-01-01

The response function of a 12.5 cm diameter NE213 scintillator detector has been measured over neutron energies ranging from 4.9 to 16.6 MeV. Beams of monoenergetic neutrons were produced using the [sup 2]H(d, n)[sup 3]He reaction. The response function is about 12% lower than previously reported values for a similar detector obtained using a continuous spectrum of neutrons from a [sup 252]Cf fission source. However, the present response function agrees with portions of data sets obtained in published work that used monoenergetic neutron source reactions. (orig.)

Main building complex WWER 440/213 upper range design response spectra for soft soil site conditions (Paks)

International Nuclear Information System (INIS)

Krutzik, N.

1996-01-01

Within the Benchmark studies parallel investigation were prepared for the main building complex of the WWER-440/213 Paks NPP by several participating institutions. The investigations were based on various mathematical models and procedures but all had the same seismological data as input. The calculation methods as well as software tools were different. This report covers the enveloped response results which were the basis for the benchmark studies and which should be used for upgrading of mechanical and electrical components and systems which will follow. These response spectra which consider a certain conservatism namely neglecting the frequency independence of the stiffness and the cut-off of damping values are named 'Upper Range design Benchmark Response Spectra' for the main building of Paks NPP

Main building complex WWER 440/213 upper range design response spectra for soft soil site conditions (Paks)

Energy Technology Data Exchange (ETDEWEB)

Krutzik, N [Siemens AG, Power Generation Group (KWU) NDA2, Offenbach (Germany)

1996-07-01

Within the Benchmark studies parallel investigation were prepared for the main building complex of the WWER-440/213 Paks NPP by several participating institutions. The investigations were based on various mathematical models and procedures but all had the same seismological data as input. The calculation methods as well as software tools were different. This report covers the enveloped response results which were the basis for the benchmark studies and which should be used for upgrading of mechanical and electrical components and systems which will follow. These response spectra which consider a certain conservatism namely neglecting the frequency independence of the stiffness and the cut-off of damping values are named 'Upper Range design Benchmark Response Spectra' for the main building of Paks NPP.

Analysis of core damage frequency: Nuclear power plant Dukovany, VVER/440 V-213 Unit 1, internal events. Volume 1: Main report

International Nuclear Information System (INIS)

Pugila, W.J.

1994-01-01

This report presents the final results from the Level 1 probabilistic safety assessment (PSA) for the Dukovany VVER/440 V-213 nuclear power plant, Unit 1. Section 1.1 describes the objectives of this study. Section 1.2 discusses the approach that was used for completing the Dukovany PSA. Section 1.3 summarizes the results of the PSA. Section 1.4 provides a comparison of the results of the Dukovany PSA with the results of other PSAs for different types of reactors worldwide. Section 1.5 summarizes the conclusions of the Dukovany PSA

An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers

NARCIS (Netherlands)

Timmer, T; Terpstra, P; van den Berg, Anke; Veldhuis, PMJF; Ter Elst, A; van der Veen, AY; Kok, K; Naylor, SL; Buys, CHCM

1999-01-01

In searching for a tumor suppressor gene in the 3p21.3 region, we isolated two genes, RBM5 and RBM6. Sequence analysis indicated that these genes share similarity. RBM5 and-to a lesser extent-RBM6 also have similarity to DXS8237E at Xp11.3-11.23, which maps less than 20 kb upstream of UBE1. A

Dietary lead intakes for mother/child pairs and relevance to pharmacokinetic models.

Science.gov (United States)

Gulson, B L; Mahaffey, K R; Vidal, M; Jameson, C W; Law, A J; Mizon, K J; Smith, A J; Korsch, M J

1997-12-01

Blood and environmental samples, including a quarterly 6-day duplicate diet, for nine mother/child pairs from Eastern Europe have been monitored for 12 to >24 months with high precision stable lead isotope analysis to evaluate the changes that occur when the subjects moved from one environment (Eastern Europe) to another with different stable lead isotopes (Australia). The children were between 6 and 11 years of age and the mothers were between 29 and 37 years of age. These data were compared with an Australian control mother/child pair, aged 31 and 6 years, respectively. A rationale for undertaking this study of mother/child pairs was to evaluate if there were differences in the patterns and clearance rates of lead from blood in children compared with their mothers. Blood lead concentrations ranged from 2.1 to 3.9 microg/dl in the children and between 1.8 and 4.5 microg/dl in the mothers, but the mean of differences between each mother and her child did not differ significantly from zero. Duplicate diets contained from 2.4 to 31.8 microg Pb/kg diet; the mean+/- standard deviation was 5.5 +/- 2.1 microg Pb/kg and total daily dietary intakes ranged from 1.6 to 21.3 microg/day. Mean daily dietary intakes relative to body weight showed that the intake for children was approximately double that for the mothers (0.218 vs. 0. 113 microg Pb/kg body weight/day). The correlations between blood lead concentration and mean daily dietary intake either relative to body weight or total dietary intake did not reach statistical significance (p>0.05). Estimation of the lead coming from skeletal (endogenous) sources relative to the contribution from environmental (exogenous) sources ranges from 8 to 70% for the mothers and 12 to 66% for the children. The difference between mothers and children is not statistically significant (p = 0.28). The children do not appear to achieve the Australian lead isotopic profile at a faster rate than their mothers. These data provide evidence that

MO-D-213-02: Quality Improvement Through a Failure Mode and Effects Analysis of Pediatric External Beam Radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Gray, J; Lukose, R; Bronson, J; Chandler, B; Merchant, T; Farr, J [St. Jude Children’s Research Hospital, Memphis, TN (United States)

2015-06-15

Purpose: To conduct a failure mode and effects analysis (FMEA) as per AAPM Task Group 100 on clinical processes associated with teletherapy, and the development of mitigations for processes with identified high risk. Methods: A FMEA was conducted on clinical processes relating to teletherapy treatment plan development and delivery. Nine major processes were identified for analysis. These steps included CT simulation, data transfer, image registration and segmentation, treatment planning, plan approval and preparation, and initial and subsequent treatments. Process tree mapping was utilized to identify the steps contained within each process. Failure modes (FM) were identified and evaluated with a scale of 1–10 based upon three metrics: the severity of the effect, the probability of occurrence, and the detectability of the cause. The analyzed metrics were scored as follows: severity – no harm = 1, lethal = 10; probability – not likely = 1, certainty = 10; detectability – always detected = 1, undetectable = 10. The three metrics were combined multiplicatively to determine the risk priority number (RPN) which defined the overall score for each FM and the order in which process modifications should be deployed. Results: Eighty-nine procedural steps were identified with 186 FM accompanied by 193 failure effects with 213 potential causes. Eighty-one of the FM were scored with a RPN > 10, and mitigations were developed for FM with RPN values exceeding ten. The initial treatment had the most FM (16) requiring mitigation development followed closely by treatment planning, segmentation, and plan preparation with fourteen each. The maximum RPN was 400 and involved target delineation. Conclusion: The FMEA process proved extremely useful in identifying previously unforeseen risks. New methods were developed and implemented for risk mitigation and error prevention. Similar to findings reported for adult patients, the process leading to the initial treatment has an

Comparative analysis of CD138 antigen targeting for the treatment of multiple myeloma with bismuth-213 and Melphalan chemotherapy

International Nuclear Information System (INIS)

Gouard, S.; Gaschet, J.; Maurel, C.; Barbet, J.; Davodeau, F.; Pallardy, A.; Faivre-Chauvet, A.; Kraeber-Bodere, F.; Bruchertseifer, F.; Morgenstern, A.; Cherel, M.

2015-01-01

Full text of publication follows. Aim: multiple myeloma (MM) is a B-cell malignancy of terminally differentiated plasma cells within the bone marrow, with the presence of a monoclonal immunoglobulin in serum and/or urine and development of osteolytic bone lesions in human. Despite intense research to develop new treatments, cure is almost never achieved. Alpha-radioimmunotherapy (RIT) has been shown to be effective in vivo in a multiple myeloma model and seems particularly suited for disseminated tumour cells or small clusters of tumour cells. CD138 (Syndecan-1) is found mainly in epithelial cells, but has been shown to be expressed by most myeloma cells, both in human and in mouse. In order to define where alpha RIT stands in MM treatment, the aim of this study was to compare Melphalan, MM standard treatment, with alpha RIT using a bismuth-213-labelled anti-mouse CD138 rat antibody in a syngeneic mouse MM model. Material and Methods: C57BL/KaLwRij mice were grafted with 10 6 5T33 cells (murine myeloma cells). Luciferase transfected 5T33 were used for in vivo localization of the cells during the course of disease. The first step of the study was to assess the dose-response of Melphalan (100, 200 et 300 μg/mouse), 21 days after engraftment. The second step consisted in therapeutic association: Melphalan followed by RIT at d22 et d25 after engraftment. Toxicity (animal weight, blood cell counts) and treatment efficacy were studied in animals receiving no treatment, injected with Melphalan alone (200 μg), RIT alone at d22 and d25 (3.7 MBq of 213 Bi-anti-CD138) and Melphalan combined with alpha RIT. Results: fifty percent of untreated mice died by d64 after MM engraftment. In mice treated with Melphalan alone, only the 200 μg dose improved median survival. No animal was cured after Melphalan treatment whereas 60% of the mice survived with RIT alone at d22 after tumour engraftment. However, the therapeutic window seems to be narrow, indeed no effect was observed with

Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera

Science.gov (United States)

Sun, Zhihong; Harris, Hugh M. B.; McCann, Angela; Guo, Chenyi; Argimón, Silvia; Zhang, Wenyi; Yang, Xianwei; Jeffery, Ian B; Cooney, Jakki C.; Kagawa, Todd F.; Liu, Wenjun; Song, Yuqin; Salvetti, Elisa; Wrobel, Agnieszka; Rasinkangas, Pia; Parkhill, Julian; Rea, Mary C.; O'Sullivan, Orla; Ritari, Jarmo; Douillard, François P.; Paul Ross, R.; Yang, Ruifu; Briner, Alexandra E.; Felis, Giovanna E.; de Vos, Willem M.; Barrangou, Rodolphe; Klaenhammer, Todd R.; Caufield, Page W.; Cui, Yujun; Zhang, Heping; O'Toole, Paul W.

2015-01-01

Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species. PMID:26415554

Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera.

Science.gov (United States)

Sun, Zhihong; Harris, Hugh M B; McCann, Angela; Guo, Chenyi; Argimón, Silvia; Zhang, Wenyi; Yang, Xianwei; Jeffery, Ian B; Cooney, Jakki C; Kagawa, Todd F; Liu, Wenjun; Song, Yuqin; Salvetti, Elisa; Wrobel, Agnieszka; Rasinkangas, Pia; Parkhill, Julian; Rea, Mary C; O'Sullivan, Orla; Ritari, Jarmo; Douillard, François P; Paul Ross, R; Yang, Ruifu; Briner, Alexandra E; Felis, Giovanna E; de Vos, Willem M; Barrangou, Rodolphe; Klaenhammer, Todd R; Caufield, Page W; Cui, Yujun; Zhang, Heping; O'Toole, Paul W

2015-09-29

Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species.

Next-to-leading order effective field theory Lambda N -> NN potential in coordinate space

Czech Academy of Sciences Publication Activity Database

Peréz-Obiol Castaneda, Axel; Entem, D. R.; Julia-Diaz, B.; Parreno, A.

2016-01-01

Roč. 954, OCT (2016), s. 213-241 ISSN 0375-9474 R&D Projects: GA ČR(CZ) GA15-04301S Institutional support: RVO:61389005 Keywords : non-mesonic weak decay * effective field theory * hypernuclei Subject RIV: BE - Theoretical Physics Impact factor: 1.916, year: 2016

A Political Decision Disguised as Legal Argument? Opinion 2/13 and European Union Accession to the European Convention on Human Rights

Directory of Open Access Journals (Sweden)

Graham Butler

2015-08-01

Full Text Available David Thór Björgvinsson was a judge of the European Court of Human Rights between 2004 and 2013. During this period, he was involved in many important judgments, including 'Scoppola v Italy (No. 3',[1] 'Eweida and others v United Kingdom',[2] and 'Al-Jedda v the United Kingdom',[3] amongst others, and went on to serve as Vice-President of the Fourth Section. He has degrees from the University of Iceland, Duke University School of Law, and the University of Strasbourg, and is currently a Professor of Law at the Centre of Excellence for International Courts (iCourts at the Faculty of Law, University of Copenhagen, Denmark. In this interview, carried out in June 2015 for the Utrecht Journal of International and European Law, David Thór Björgvinsson outlined his views to Graham Butler on Opinion 2/13 from the Court of Justice of the European Union on the Union’s accession to the European Convention on Human Rights,[4] the workings of the European Court of Human Rights, and what the future may have in store for this Court. [1] 'Scoppola v Italy (No. 3' (2013 56 EHRR 19. [2] 'Eweida and others v United Kingdom' (2013 57 EHRR 8. [3] 'Al-Jedda v the United Kingdom' (2011 53 EHRR 23. [4] Opinion 2/13 (2014 Accession of the European Union to the European Convention for the Protection of Human Rights and Fundamental Freedoms, (not yet reported.

A Political Decision Disguised as Legal Argument? Opinion 2/13 and European Union Accession to the European Convention on Human Rights

Directory of Open Access Journals (Sweden)

Graham Butler

2015-08-01

Full Text Available David Thór Björgvinsson was a judge of the European Court of Human Rights between 2004 and 2013. During this period, he was involved in many important judgments, including 'Scoppola v Italy (No. 3',[1] Eweida and others v United Kingdom,[2] and 'Al-Jedda v the United Kingdom';a title="" href="#_ftn3">[3] amongst others, and went on to serve as Vice-President of the Fourth Section. He has degrees from the University of Iceland, Duke University School of Law, and the University of Strasbourg, and is currently a Professor of Law at the Centre of Excellence for International Courts (iCourts at the Faculty of Law, University of Copenhagen, Denmark. In this interview, carried out in June 2015 for the Utrecht Journal of International and European Law, David Thór Björgvinsson outlined his views to Graham Butler on Opinion 2/13 from the Court of Justice of the European Union on the Union’s accession to the European Convention on Human Rights,[4] the workings of the European Court of Human Rights, and what the future may have in store for this Court.[1] Scoppola v Italy (No. 3 (2013 56 EHRR 19.[2] Eweida and others v United Kingdom (2013 57 EHRR 8.[3] Al-Jedda v the United Kingdom (2011 53 EHRR 23.[4] Opinion 2/13 (2014 Accession of the European Union to the European Convention for the Protection of Human Rights and Fundamental Freedoms, (not yet reported.

Selective T-cell Ablation with Bismuth-213 Labeled Anti-TCR Alpha Beta as Nonmyeloablative Conditionaing for Allogeneic Canine Marrow Transplantion

Energy Technology Data Exchange (ETDEWEB)

Bethge, W. A.; Wilbur, D. Scott; Storb, R.; Hamlin, Donald K.; Santos, E. B.; Brechbiel, M. W.; Fisher, Darrell R.; Sandmaier, B. M.

2003-06-15

Two major immunological barriers, the host versus graft (HVG) and the graft versus host (GVH) reaction, must be overcome for successful allogeneic hematopoietic stem cell transplantation. T-cells are involved in these barriers in the major histocompatibility complex-identical settings. We hypothesized that selective ablation of T-cells using radioimmunotherapy, together with postgrafting immunosuppression, would ensure stable allogeneic engraftment. We developed a canine model of nonmyeloablative marrow transplantation in which host immune reactions are impaired by a single dose of 2 Gy total body irradiation (TBI), and where both GVH and residual HVG reactions are controlled by postgrafting immunosuppression with mycophenolate mofetil (MMF) and cyclosporine (CSP). We substituted the alpha-emitter bismuth-213 linked to a monoclonal antibody against TCR(alpha,beta)using the metal-binding chelate CHX-A”-DTPA, for 2 Gy TBI. Biodistribution studies using a gamma-emitting indium-111-labeled anti-TCR mAb showed uptake primarily in blood, marrow, lymph nodes, spleen and liver. In a dosimetry study, 4 dogs were treated with 0.13-0.46 mg/kg TCR mAb labeled with 3.7-5.6 mCi/kg (137-207 MBq/kg) Bi-213. The treatment was administered in 6 injections on days -3 and -2 followed by transplantion of dog leukocyte antigen-identical marrow on day 0 and postgrafting immunosuppression with MMF and CSP. Therapy was well tolerated except for elevations of transaminases, which were transient in all but one dog. No other organ toxicities or signs of graft-versus-host-disease were noted. The dogs had prompt allogeneic hematopoietic engraftment and achieved stable mixed donor-host hematopoietic chimerism with donor contributions ranging from 5-55 % with >30 weeks follow up.

Selective T-cell Ablation with Bismuth-213 Labeled Anti-TCR Alpha Beta as Nonmyeloablative Conditioning for Allogeneic Canine Marrow Transplantion

International Nuclear Information System (INIS)

Bethge, W. A.; Wilbur, D. Scott; Storb, R.; Hamlin, Donald K.; Santos, E. B.; Brechbiel, M. W.; Fisher, Darrell R.; Sandmaier, B. M.

2003-01-01

Two major immunological barriers, the host versus graft (HVG) and the graft versus host (GVH) reaction, must be overcome for successful allogeneic hematopoietic stem cell transplantation. T-cells are involved in these barriers in the major histocompatibility complex-identical settings. We hypothesized that selective ablation of T-cells using radioimmunotherapy, together with postgrafting immunosuppression, would ensure stable allogeneic engraftment. We developed a canine model of nonmyeloablative marrow transplantation in which host immune reactions are impaired by a single dose of 2 Gy total body irradiation (TBI), and where both GVH and residual HVG reactions are controlled by postgrafting immunosuppression with mycophenolate mofetil (MMF) and cyclosporine (CSP). We substituted the alpha-emitter bismuth-213 linked to a monoclonal antibody against TCR(alpha,beta)using the metal-binding chelate CHX-A-DTPA, for 2 Gy TBI. Biodistribution studies using a gamma-emitting indium-111-labeled anti-TCR mAb showed uptake primarily in blood, marrow, lymph nodes, spleen and liver. In a dosimetry study, 4 dogs were treated with 0.13-0.46 mg/kg TCR mAb labeled with 3.7-5.6 mCi/kg (137-207 MBq/kg) Bi-213. The treatment was administered in 6 injections on days -3 and -2 followed by transplantion of dog leukocyte antigen-identical marrow on day 0 and postgrafting immunosuppression with MMF and CSP. Therapy was well tolerated except for elevations of transaminases, which were transient in all but one dog. No other organ toxicities or signs of graft-versus-host-disease were noted. The dogs had prompt allogeneic hematopoietic engraftment and achieved stable mixed donor-host hematopoietic chimerism with donor contributions ranging from 5-55 % with >30 weeks follow up

Spallation neutron spectrum on a massive lead/paraffin target irradiated with 1 GeV protons

Czech Academy of Sciences Publication Activity Database

Adam, Jindřich; Balabekyan, A. R.; Barashenkov, V. S.; Brandt, R.; Golovatiouk, V. M.; Kalinnikov, V. G.; Katovsky, K.; Krivopustov, M. I.; Kumar, V.; Kumawat, H.; Odoj, R.; Pronskikh, V. S.; Solnyshkin, A. A.; Stegailov, V. I.; Tsoupko-Sitnikov, V. M.; Westmeier, W.

2005-01-01

Roč. 23, č. 1 (2005), s. 61-68 ISSN 1434-6001 R&D Projects: GA MŠk 1P04LA213 Keywords : monitor reactions * beams * ionization Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.659, year: 2005

In vivo x-ray fluorescence of bone lead in the study of human lead metabolism: Serum lead, whole blood lead, bone lead, and cumulative exposure

International Nuclear Information System (INIS)

Cake, K.M.; Chettle, D.R.; Webber, C.E.; Gordon, C.L.

1995-01-01

Traditionally, clinical studies of lead's effect on health have relied on blood lead levels to indicate lead exposure. However, this is unsatisfactory because blood lead levels have a half-life of approximately 5 weeks, and thus reflect recent exposure. Over 90% of the lead body burden is in bone, and it is thought to have a long residence time, thus implying that measurements of bone lead reflect cumulative exposure. So, measurements of bone lead are useful in understanding the long-term health effects of lead. Ahlgren reported the first noninvasive measurements of bone lead in humans, where γ-rays from 57 Co were used to excite the K series x-rays of lead. The lead detection system at McMaster University uses a 109 Cd source which is positioned at the center of the detector face (HPGe) and a near backscatter (∼160 degrees) geometry. This arrangement allows great flexibility, since one can sample lead in a range of different bone sites due to a robust normalization technique which eliminates the need to correct for bone geometry, thickness of overlying tissue, and other related factors. The effective radiation dose to an adult during an x-ray fluorescence bone lead measurement is extremely low, being 35 nSv. This paper addresses the issue of how bone, whole blood, and serum lead concentrations can be related in order to understand a person's lead exposure history

Rovibrational study of the 2ν2 band of D213CO by high-resolution Fourier transform infrared spectroscopy

Science.gov (United States)

Wu, Q. Y.; Tan, T. L.; A'dawiah, Rabia'tul; Ng, L. L.

2018-03-01

The high-resolution FTIR spectrum of the 2ν2 band (3250-3380 cm-1) of D213CO was recorded at an unapodized resolution of 0.0063 cm-1. A total of 747 rovibrational transitions have been assigned and fitted up to J″ = 32 and Ka″ = 10 using the Watson's A-reduced Hamiltonian in the Ir representation. A set of accurate upper state (v2 = 2) rovibrational constants, three rotational and five quartic centrifugal distortion constants, were determined for the first time. The band center of the 2ν2 band was found to be 3326.765109 ± 0.000079 cm-1. The rms deviation of the rovibrational fit was 0.00096 cm-1.

Seismic safety programme at NPP Paks. Propositions for coordinated international activity in seismic safety of the WWER-440 V-213

International Nuclear Information System (INIS)

Katona, T.

1995-01-01

This paper presents the Paks NPP seismic safety program, highlighting the specifics of the WWER-440/213 type in operation, and the results of work obtained so far. It covers the following scope: establishment of the seismic safety program (original seismic design, current requirements, principles and structure of the seismic safety program); implementation of the seismic safety program (assessing the seismic hazard of the site, development of the new concept of seismic safety for the NPP, assessing the seismic resistance of the building and the technology); realization of the seismic safety of higher level (technical solutions, drawings, realization); ideas and propositions for coordinated international activity

Evaluation of fatigue crack growth in the primary circuit pipeline of a WWER 440/213c type nuclear power plant

International Nuclear Information System (INIS)

Samohyl, P.

1993-07-01

The fatigue damage of the primary circuit of WWER-440/213c reactors was evaluated proceeding from actual and design operating data of units 3 and 4 of the Bohunice V-2 nuclear power plant. A complex computation model was set up, encompassing the main circulation pipeline, pressurizer pipeline, emergency core aftercooling system pipeline, steam pipeline, and feedwater pipeline. The standardized STATIC code was applied to the stress analysis, and the FATLBB code was used to determine the crack increment for all operating states and primary circuit sections. The probability of fatigue failure of the pipelines was found to be low. (J.B.). 55 tabs., 3 figs., 9 refs

Structural and functional studies of FKHR-PAX3, a reciprocal fusion gene of the t(2;13 chromosomal translocation in alveolar rhabdomyosarcoma.

Directory of Open Access Journals (Sweden)

Qiande Hu

Full Text Available Alveolar rhabdomyosarcoma (ARMS is an aggressive pediatric cancer of skeletal muscle. More than 70% of ARMS tumors carry balanced t(2;13 chromosomal translocation that leads to the production of two novel fusion genes, PAX3-FKHR and FKHR-PAX3. While the PAX3-FKHR gene has been intensely studied, the reciprocal FKHR-PAX3 gene has rarely been described. We report here the cloning and functional characterization of the FKHR-PAX3 gene as the first step towards a better understanding of its potential impact on ARMS biology. From RH30 ARMS cells, we detected and isolated three versions of FKHR-PAX3 cDNAs whose C-terminal sequences corresponded to PAX3c, PAX3d, and PAX3e isoforms. Unlike the nuclear-specific localization of PAX3-FKHR, the reciprocal FKHR-PAX3 proteins stayed predominantly in the cytoplasm. FKHR-PAX3 potently inhibited myogenesis in both non-transformed myoblast cells and ARMS cells. We showed that FKHR-PAX3 was not a classic oncogene but could act as a facilitator in oncogenic pathways by stabilizing PAX3-FKHR expression, enhancing cell proliferation, clonogenicity, anchorage-independent growth, and matrix adhesion in vitro, and accelerating the onset of tumor formation in xenograft mouse model in vivo. In addition to these pro-oncogenic behaviors, FKHR-PAX3 also negatively affected cell migration and invasion in vitro and lung metastasis in vivo. Taken together, these functional characteristics suggested that FKHR-PAX3 might have a critical role in the early stage of ARMS development.

Repensando la libertad de expresión desde el abordaje al art. 213 del Código Penal argentino

Directory of Open Access Journals (Sweden)

Matalone, Noelia

2013-12-01

Full Text Available Este ensayo intenta presentar abordajes críticos sobre el delito tipificado en el art. 213 del Código Penal. En tal temperamento, se contrapone el tipo penal de apología del delito con los derechos individuales de las personas, en particular, la libertad de expresión. En este sentido, la autora formula una propuesta de derogación de la norma, como consecuencia de los fundamentos y efectos de esta norma, todo ello en orden a preservar, por sobre los intereses que puedan sostener este tipo de prohibición, la pluralidad de voces en la sociedad. Para ello, apela al sentido de la tolerancia social y a los principios de razonalibidad y de necesidad del sistema penal al momento de investigar y perseguir este tipo de casos.

Total contribution of airborne lead to blood lead.

OpenAIRE

Manton, W I

1985-01-01

A nine year study of blood lead concentrations and isotope ratios carried out on a married couple shows that pulmonary deposition cannot account for all the airborne lead in blood; that lead from bone may comprise 70% of blood lead; and that during pregnancy blood lead may double due to mobilisation of lead from bone.

Report of a consultants meeting on draft guidelines for WWER 440/213 containment evaluation

International Nuclear Information System (INIS)

Andrieu, R.; Barre, F.; Birbraer, A.N.

1995-01-01

This report has been prepared at two Consultants' Meetings of experts from France, Germany, Russia, Slovakia, Spain and Ukraine, organized within the framework of the IAEA Extrabudgetary Programme on the Safety of WWER NPPs. In view of the limited time available and the complexity of the task the present report should be treated as a draft, which will be sent to the national regulatory bodies for review and further improvement. The next meeting on the subject will be held in June 1996 with the participation of representatives of all countries operating WWER 440/213 reactors with bubbler condenser containments. During the meeting, the acceptance criteria and review requirements formulated in the IAEA NUSS Series and those in force in the Russian Federation, the United States of America, Germany, France, the Czech Republic, and Slovakia have been taken into consideration. The equivalence of the technical goals which are aimed to be achieved by applying comparable national criteria has been checked in order to avoid multiple addressing the issues and to assure the completeness of the acceptance criteria necessary to assess the design of the containment systems. 48 refs, 12 tabs

Total contribution of airborne lead to blood lead.

Science.gov (United States)

Manton, W I

1985-01-01

A nine year study of blood lead concentrations and isotope ratios carried out on a married couple shows that pulmonary deposition cannot account for all the airborne lead in blood; that lead from bone may comprise 70% of blood lead; and that during pregnancy blood lead may double due to mobilisation of lead from bone. PMID:3970881

Lead- or Lead-bismuth-cooled fast reactors

International Nuclear Information System (INIS)

Bouchter, J.C.; Courouau, J.L.; Dufour, P.; Guidez, J.; Latge, C.; Martinelli, L.; Renault, C.; Rimpault, G.

2014-01-01

Lead-cooled fast reactors are one of the 6 concepts retained for the 4. generation of nuclear reactors. So far no lead-cooled reactors have existed in the world except lead-bismuth-cooled reactors in soviet submarines. Some problems linked to the use of the lead-bismuth eutectic appeared but were satisfactorily solved by a more rigorous monitoring of the chemistry of the lead-bismuth coolant. Lead presents various advantages as a coolant: no reactivity with water and the air,a high boiling temperature and low contamination when irradiated. The main asset of the lead-bismuth alloy is the drop of the fusion temperature from 327 C degrees to 125 C degrees. The main drawback of using lead (or lead-bismuth) is its high corrosiveness with metals like iron, chromium and nickel. The high corrosiveness of the coolant implies low flow velocities which means a bigger core and consequently a bigger reactor containment. Different research programs in the world (in Europe, Russia and the USA) are reviewed in the article but it appears that the development of this type of reactor requires technological breakthroughs concerning materials and the resistance to corrosion. Furthermore the concept of lead-cooled reactors seems to be associated to a range of low output power because of the compromise between the size of the reactor and its resistance to earthquakes. (A.C.)

Lead in teeth from lead-dosed goats: Microdistribution and relationship to the cumulative lead dose

International Nuclear Information System (INIS)

Bellis, David J.; Hetter, Katherine M.; Jones, Joseph; Amarasiriwardena, Dula; Parsons, Patrick J.

2008-01-01

Teeth are commonly used as a biomarker of long-term lead exposure. There appear to be few data, however, on the content or distribution of lead in teeth where data on specific lead intake (dose) are also available. This study describes the analysis of a convenience sample of teeth from animals that were dosed with lead for other purposes, i.e., a proficiency testing program for blood lead. Lead concentration of whole teeth obtained from 23 animals, as determined by atomic absorption spectrometry, varied from 0.6 to 80 μg g -1 . Linear regression of whole tooth lead (μg g -1 ) on the cumulative lead dose received by the animal (g) yielded a slope of 1.2, with r 2 =0.647 (p -1 , were found in circumpulpal dentine. Linear regression of circumpulpal lead (μg g -1 ) on cumulative lead dose (g) yielded a slope of 23 with r 2 =0.961 (p=0.0001). The data indicated that whole tooth lead, and especially circumpulpal lead, of dosed goats increased linearly with cumulative lead exposure. These data suggest that circumpulpal dentine is a better biomarker of cumulative lead exposure than is whole tooth lead, at least for lead-dosed goats

The optimum lead thickness for lead-activation detectors

International Nuclear Information System (INIS)

Si Fenni; Hu Qingyuan

2009-01-01

The optimum lead thickness for lead-activation detectors has been studied in this paper. First existence of the optimum lead thickness is explained theoretically. Then the optimum lead thickness is obtained by two methods, MCNP5 calculation and mathematical estimation. At last factors which affect the optimum lead thickness are discussed. It turns out that the optimum lead thickness is irrelevant to incident neutron energies. It is recommended 2.5 cm generally.

Completion of the VVER 440/213 NPP Mochovce incorporation enhanced safety features

International Nuclear Information System (INIS)

Charbonneau, S.; Eckert, G.

1996-01-01

The cooperation between the western countries and the countries of ex-eastern block in the field of nuclear safety is recent and still limited. The main reasons for this situation are limited or non existent capabilities of these countries for financing as well as non acceptable legal conditions concerning the third party nuclear liability in this part of Europe. Nevertheless, Framatome and Siemens associated in the consortium named EUCOM, have signed in April 1996 the contract of about 100 million US dollars with Slovak electricity company (SLOVENSKE ELEKTRARNE-SE) for upgrading the Units 1 and 2 of Mochovce Nuclear Power Plant according to the western safety standards. This is the first important project involving west-european companies in the modernisation of Russian type of pressurized water reactor (VVER 440/213). The consortium will cooperate with other partners involved in the project: Slovak, Czech and Russian. The financing of the project will be provided mainly form Slovak and Czech sources. The safety upgrading will be financed through French and German buyer credits. French company Electricite de France (EDF) will be the consultant for SE. The safety upgrading measures have been elaborated taking into account the recommendation of Vienna International Atomic Energy Agency (IAEA) and the evaluation of the safety realised by RISKAUDIT, the common organization of German and French safety authorities (GSR and IPSN). Hence all guaranties have been taken to fulfil the western safety criteria for Nuclear Power Plant Mochovce. (author)

Failure evaluation on a high-strength alloy SA213-T91 super heater tube of a power generation

Energy Technology Data Exchange (ETDEWEB)

Ahmad, J.; Purbolaksono, J.; Beng, L.C.; Ahmad, A. [University of Tenaga Nas, Kajang (Malaysia). Dept. of Mechanical Engineering

2010-07-01

This article presents failure investigation on a high-strength alloy SA213-T91 superheater tube. This failure is the first occurrence involving the material in Kapar Power Station Malaysia. The investigation includes visual inspections, hardness measurements, and microscopic examinations. The failed super-heater tube shows a wide open rupture with thin and blunt edges. Hardness readings on all the as-received tubes are used for estimating the operating metal temperature of the super-heater tubes. Microstructures of the failed tube show numerous creep cavities consisting of individual pores and chain of pores which form micro-and macro-cracks. The findings confirmed that the super-heater tube is failed by short-term overheating. Higher temperatures of the flue gas due to the inconsistent feeding of pulverized fuels into the burner is identified to cause overheating of the failed tube.

Evaluation of preclinical single and multiple dose toxicity and efficacy of 213 Bi-labeled plasminogen activator inhibitor 2 for breast and prostate cancer

International Nuclear Information System (INIS)

Rizvi, S.; Li, Y.; Allen, B.; Littlejohn, T.; Ranson, M.; Links, M.; Irving, D.; Andrews, J.

2003-01-01

The aim of the study was to evaluate the single and multiple dose toxicity (maximum tolerated dose or MTD) regimes for 213 Bi-labeled PAI2. Dose range of 2-8 mCi/kg was used for the single dose toxicity studies. It was found that end point (20% weight loss and/or distressed behaviour) was not reached for the highest dose either with single or multiple dose injections. For multiple dose toxicity studies, the dose levels ranged between 0.4 - 2 mCi/kg, and were administered daily for 5 days. The highest level tested (2mCi/kg/day x 5) was the maximum tolerated dose as 3/6 mice succumbed to the endpoints. However, histological examination of major organs showed no adverse morphological changes. From these toxicity studies, we concluded that either a dose of 1.6mCi/kg of 213 Bi-PAI2 per day for 5 days or a single injection of 8 mCi/kg can be administered without reaching the endpoints. These dose levels were used for efficacy trials. The efficacy studies were conducted to examine if the 1.6mCi/kgday x 5 multiple dose schedule (sub-maximum tolerated dose) showed efficacy against established and early stage human breast and prostate tumours in mice. Statistical analyses of the data indicate a significant tumour growth rate delay and increased time to reach tumour size endpoint for alpha-PAI2 treatment compared to control tumours, in both pre-tumour stage and established tumour models

The cellular distribution of extracellular superoxide dismutase in macrophages is altered by cellular activation but unaffected by the natural occurring R213G substitution

DEFF Research Database (Denmark)

Gottfredsen, Randi Heidemann; Goldstrohm, David; Hartney, John

2014-01-01

and associated with the cell surface via the extracellular matrix (ECM)-binding region. Upon cellular activation induced by lipopolysaccharide, EC-SOD is relocated and detected both in the cell culture medium and in lipid raft structures. Although the secreted material presented a significantly reduced ligand......-binding capacity, this could not be correlated to proteolytic removal of the ECM-binding region, because the integrity of the material recovered from the medium was comparable to that of the cell surface-associated protein. The naturally occurring R213G amino acid substitution located in the ECM-binding region...

Optoelectronic properties of fluorene-co-4,7-difuran-2,1,3-benzothiadiazole copolymers

Institute of Scientific and Technical Information of China (English)

无

2010-01-01

Light-emitting and photovoltaic properties of copolymers(PFO-FBT) based on 9,9-dioctylfluorene and 4,7-difuran-2,1,3-benzothiadiazole(FBT) units were investigated.The copolymers show two absorbance peaks at around 382 nm and 530 nm,respectively.The relative absorbance at around 530 nm of the PFO-FBT copolymers increases with the increasing FBT content.The EL emissions are red-shifted from 611 nm to 702 nm by increasing the FBT content in the copolymer.The highest EL external quantum efficiency achieved with the device configuration of ITO/PEDOT/PVK/PFO-FBT0.1/Ba/Al is 2.32% with the luminance of 441.3 cd/m2 at a current density of 33 mA/cm2.Efficient energy transfer due to exciton trapping on low band-gap FBT sites was observed.The bulk-heterojunction photovoltaic cell used PFO-FBT50 copolymer as the electron donor and methanofullerene [6,6]-phenyl C61-butyric acid methyl ester(PCBM) as the electron acceptor shows an energy conversion efficiency of 1.13% with open-circuit voltage(Voc) of 0.85 V and short-circuit current density(Jsc) of 3.39 mA/cm2 under AM 1.5 solar simulator(100 mW/cm2),and the edge of the spectral photoresponse is at ～750 nm.

A disseminated alveolar rhabdomyosarcoma in a 9-year-old boy disclosed by chromosomal translocation (2;13) (q35;q14)

Science.gov (United States)

Brichard, B; Ninane, J; Gosseye, S; Verellen-Dumoulin, C; Vermylen, C; Rodhain, J; Cornu, G

1991-01-01

A 9-year-old boy presented with a small subcutaneous tumor of the trunk and diffuse bone marrow involvement. The first histological diagnosis given was undifferentiated malignancy possibly of neural crest origin and chemotherapy was started immediately using vincristine, cyclophosphamide, cisplatin, and teniposide (OPEC). Complete response was achieved after four courses of chemotherapy. Histological slides were then reviewed and the final diagnosis of alveolar rhabdomyosarcoma (RMS) was retained. Moreover, chromosome analysis of malignant cells in the bone marrow revealed a translocation involving chromosomes 2 and 13:t(2;13) (q35;q14). This specific karyotype finding has been recently reported in a few cases and could be specific for alveolar RMS. The patient had a relapse 7 months after diagnosis and died 4 months later.

Lead poisoning

Energy Technology Data Exchange (ETDEWEB)

Beijers, J A

1952-01-01

Three cases of acute lead poisoning of cattle herds via ingestion are reported, and reference is made to several other incidents of lead in both humans and animals. The quantity of lead which was found in the livers of the dead cows varied from 6.5 to 19 mg/kg, while 1160 mg/kg of lead in the liver was found for a young cow which was poisoned experimentally with 5 gms of lead acetate per day; hence, there appears to be great variability in the amounts deposited that can lead to intoxication and death. No evidence was found for a lead seam around the teeth, prophyrinuria, or basophil granules in the erythrocytes during acute or chronic lead poisoning of cattle or horses examined. Reference is made to attempts of finding the boundary line between increased lead absorption and lead intoxication in humans, and an examination of 60 laborers in an offset-printing office containing a great deal of inhalable lead (0.16 to 1.9 mg/cu m air) is reviewed. Physical deviation, basophylic granulation of erythrocytes, increased lead content of the urine, and porphyrinuria only indicate an increased absorption of lead; the use of the term intoxication is justified if, in addition, there are complaints of lack of appetite, constipation, fatigue, abdominal pain, and emaciation.

Biosorption of lead phosphates by lead-tolerant bacteria as a mechanism for lead immobilization.

Science.gov (United States)

Rodríguez-Sánchez, Viridiana; Guzmán-Moreno, Jesús; Rodríguez-González, Vicente; Flores-de la Torre, Juan Armando; Ramírez-Santoyo, Rosa María; Vidales-Rodríguez, Luz Elena

2017-08-01

The study of metal-tolerant bacteria is important for bioremediation of contaminated environments and development of green technologies for material synthesis due to their potential to transform toxic metal ions into less toxic compounds by mechanisms such as reduction, oxidation and/or sequestration. In this study, we report the isolation of seven lead-tolerant bacteria from a metal-contaminated site at Zacatecas, México. The bacteria were identified as members of the Staphylococcus and Bacillus genera by microscopic, biochemical and 16S rDNA analyses. Minimal inhibitory concentration of these isolates was established between 4.5 and 7.0 mM of Pb(NO 3 ) 2 in solid and 1.0-4.0 mM of Pb(NO 3 ) 2 in liquid media. A quantitative analysis of the lead associated to bacterial biomass in growing cultures, revealed that the percentage of lead associated to biomass was between 1 and 37% in the PbT isolates. A mechanism of complexation/biosorption of lead ions as inorganic phosphates (lead hydroxyapatite and pyromorphite) in bacterial biomass, was determined by Fourier transform infrared spectroscopy and X-ray diffraction analyses. Thus, the ability of the lead-tolerant isolates to transform lead ions into stable and highly insoluble lead minerals make them potentially useful for immobilization of lead in mining waste.

Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state

Science.gov (United States)

Morito, Daisuke; Nishikawa, Kouki; Hoseki, Jun; Kitamura, Akira; Kotani, Yuri; Kiso, Kazumi; Kinjo, Masataka; Fujiyoshi, Yoshinori; Nagata, Kazuhiro

2014-03-01

Moyamoya disease is an idiopathic human cerebrovascular disorder that is characterized by progressive stenosis and abnormal collateral vessels. We recently identified mysterin/RNF213 as its first susceptibility gene, which encodes a 591-kDa protein containing enzymatically active P-loop ATPase and ubiquitin ligase domains and is involved in proper vascular development in zebrafish. Here we demonstrate that mysterin further contains two tandem AAA+ ATPase modules and forms huge ring-shaped oligomeric complex. AAA+ ATPases are known to generally mediate various biophysical and mechanical processes with the characteristic ring-shaped structure. Fluorescence correlation spectroscopy and biochemical evaluation suggested that mysterin dynamically changes its oligomeric forms through ATP/ADP binding and hydrolysis cycles. Thus, the moyamoya disease-associated gene product is a unique protein that functions as ubiquitin ligase and AAA+ ATPase, which possibly contributes to vascular development through mechanical processes in the cell.

Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state

Science.gov (United States)

Morito, Daisuke; Nishikawa, Kouki; Hoseki, Jun; Kitamura, Akira; Kotani, Yuri; Kiso, Kazumi; Kinjo, Masataka; Fujiyoshi, Yoshinori; Nagata, Kazuhiro

2014-01-01

Moyamoya disease is an idiopathic human cerebrovascular disorder that is characterized by progressive stenosis and abnormal collateral vessels. We recently identified mysterin/RNF213 as its first susceptibility gene, which encodes a 591-kDa protein containing enzymatically active P-loop ATPase and ubiquitin ligase domains and is involved in proper vascular development in zebrafish. Here we demonstrate that mysterin further contains two tandem AAA+ ATPase modules and forms huge ring-shaped oligomeric complex. AAA+ ATPases are known to generally mediate various biophysical and mechanical processes with the characteristic ring-shaped structure. Fluorescence correlation spectroscopy and biochemical evaluation suggested that mysterin dynamically changes its oligomeric forms through ATP/ADP binding and hydrolysis cycles. Thus, the moyamoya disease-associated gene product is a unique protein that functions as ubiquitin ligase and AAA+ ATPase, which possibly contributes to vascular development through mechanical processes in the cell. PMID:24658080

Proposal of lead time reduction in the thermoelectric products line of a small company in the State of Sao Paulo

Directory of Open Access Journals (Sweden)

Fernanda Veríssimo Soulé

2016-03-01

Full Text Available Quick Response Manufacturing (QRM is a way manufacturing companies may increase their flexibility. Manufacturing flexibility is a key to differentiation and enhancement of competitiveness. There is few empirical research on the topic of how small and medium-sized enterprises (SME may benefit from QRM, what may impact the appropriation of this approach by these important actors of our economy. This article aims to present the results of a project which applied QRM to reduce the lead time of a small company located in the state of Sao Paulo. It was proposed to a balance the throughputs of slow operations, reducing 50% of production batches; b implement cellular manufacturing and improvements in the management of Work In Process, using the POLCA system and visual management; c implement an integrated sales and operations planning (S&OP and rules for prioritization of orders. It was identified that the proposal would generate a lead time reduction from 39 to 21.3 days and a decrease of at least 51% in the raw materials stock costs. During the research, the following conclusions could be drawn: a problems in management, investment capacity and relationship with suppliers are frequent in family-owned SMEs; b QRM approach can be adapted to work within this environment; c the knowledge developed in academia can be an important tool to help family-owned SMEs to supplant these obstacles.

Gender-dependent expression of leading and passenger strand of miR-21 and miR-16 in human colorectal cancer and adjacent colonic tissues.

Science.gov (United States)

Hasáková, K; Bezakova, J; Vician, M; Reis, R; Zeman, M; Herichova, I

2017-12-30

miRNAs are small regulatory RNA molecules involved in posttranscriptional gene silencing. Their biosynthesis results in the formation of duplex consisting of a leading and a passenger strand of mature miRNA. The leading strand exhibits the main activity but recent findings indicate a certain role of the passenger strand as well. Deregulated levels of miRNA were found in many types of cancers including colorectal cancer. miR-21 and miR-16 were indicated as possible markers of colorectal cancer, however, small attention to gender differences in their expression was paid so far. Therefore, the aim of our study was to investigate the expression of miR-21-5p, miR-21-3p, miR-16-5p and miR-16-3p in human colorectal cancer tissue and compare it to the adjacent tissues taken during surgery in men and women separately. Our results showed an up-regulation of all measured miRNAs in tumor tissue compared to adjacent tissues. As expected, tumors and adjacent tissues exhibited a significantly higher expression of leading miRNAs compared to passenger strand of miR-21 and miR-16. The expression of leading and passenger strand of miR-21 and miR-16 positively correlated exhibiting the highest correlation coefficient in the distal tissue. The expression pattern showed gender-dependent differences, with higher levels of miRNA in men than in women. Our findings indicate a gender-related expression pattern of miRNA, which should be considered as an important factor in generating new prognostic or diagnostic biomarkers.

Properties of aerosol particles generated during 213 nm laser ablation: a study of compact and powdered tungsten carbides as materials with a two-component matrix

International Nuclear Information System (INIS)

Hola, M.; Konecna, V.; Kanicky, V.; Mikuska, P.; Kaiser, J.; Hanzlikova, R.

2009-01-01

Full text: The laser ablation process of tungsten carbide hardmetals was studied using 213 nm Nd:YAG laser. The samples were presented for ablation as sintered compacts or powders pressed into pellets to compare the generation of particles from samples with similar chemical composition but different physical properties. The influence of laser ablation parameters on the aerosol generation was studied using an optical aerosol spectrometer. In the case of powders, the effect of binder amount was investigated. The structure of generated particles and the properties of ablation-craters were additionally studied by SEM. (author)

The numerical simulation of the WWER-440/V-213 reactor pressure vessel internals response to maximum hypothetical large break loss of coolant accident

International Nuclear Information System (INIS)

Hermansky, P.; Krajcovic, M.

2012-01-01

The reactor internals are designed to ensure cooling of the fuel, to ensure the movement of emergency control assemblies under all operating conditions including accidents and facilitate removal of the fuel and of the internals following an accident This paper presents results of the numerical simulation of the WWER-440/V213 reactor vessel internals dynamic response to maximum hypothetical Large-Break Loss of Coolant Accident. The purpose of this analysis is to determine the reactor vessel internals response due to rapid depressurization and to prove no such deformations occur in the reactor vessel internals which would prevent timely and proper activation of the emergency control assemblies. (Authors)

Randomized, double-blind, multicenter study of the immunogenicity and reactogenicity of 17DD and WHO 17D-213/77 yellow fever vaccines in children: implications for the Brazilian National Immunization Program.

Science.gov (United States)

2007-04-20

Vaccines against yellow fever currently recommended by the World Health Organization contain either virus sub-strains 17D or 17DD. In adults, the 17DD vaccine demonstrated high seroconversion and similar performance to vaccines manufactured with the WHO 17D-213/77 seed-lot. In another study, 17DD vaccine showed lower seroconversion rates in children younger than 2 years. Data also suggested lower seroconversion with simultaneous application of measles vaccine. This finding in very young children is not consistent with data from studies with 17D vaccines. A multicenter, randomized, double-blind clinical trial was designed (1) to compare the immunogenicity and reactogenicity of two yellow fever vaccines: 17DD (licensed product) and 17D-213/77 (investigational product) in children aged 9-23 months; (2) to assess the effect of simultaneous administration of yellow fever and the measles-mumps-rubella vaccines; and (3) to investigate the interference of maternal antibodies in the response to yellow fever vaccination. The anticipated implications of the results are changes in vaccine sub-strains used in manufacturing YF vaccine used in several countries and changes in the yellow fever vaccination schedule recommendations in national immunization programs.

Time versus frequency domain calculation of the main building complex of the VVER 440/213 NPP PAKS

International Nuclear Information System (INIS)

Katona, T.; Ratkai, S.; Halbritter, A.; Krutzik, N.J.; Schuetz, W.

1995-01-01

Various dynamic analyses were conducted for the main building complex of the VVER 440/213 PAKS in order to determine the dynamic response and assess the aseismic capacity of this nuclear power plant. Different types of mathematical models for idealizing the soil and the building structures were used. The main goal of the study presented here was to demonstrate the effects of different procedures for consideration of soil-structure interaction on the dynamic response of the structures mentioned above. The analyses were based on appropriate mathematical models of the coupled vibration structures (reactor building, turbine hall, intermediate building structures) and the layered soil. On the basis of this study, it can be concluded that substructure models using frequency-independent impedances and cut-off of modal damping usually provide conservative results. Complex models which allow the soil-soil and the structure or by frequency-dependent impedances) provide more accurate results. The latter approach results in more efficient designs which are not only safe but also economical. (author). 7 refs., 15 figs

Lead and lead-based alloys as waste matrix materials

International Nuclear Information System (INIS)

Arustamov, A.E.; Ojovan, M.I.; Kachalov, M.B.

1999-01-01

Metals and alloys with relatively low melting temperatures such as lead and lead-based alloys are considered in Russia as prospective matrices for encapsulation of spent nuclear fuel in containers in preparation for final disposal in underground repositories. Now lead and lead-based alloys are being used for conditioning spent sealed radioactive sources at radioactive waste disposal facilities

Lead poisoning

Science.gov (United States)

... drinking water in homes containing pipes that were connected with lead solder . Although new building codes require ... lead in their bodies when they put lead objects in their mouths, especially if they swallow those ...

2,1,3-benzothiadiazole-5,6-dicarboxylic imide - A versatile building block for additive- and annealing-free processing of organic solar cells with effi ciencies exceeding 8%

KAUST Repository

Nielsen, Christian Bergenstof

2014-12-15

A new photoactive polymer comprising benzo[1,2-b:3,4-b′:5,6-d′]trithiophene and 2,1,3-benzothiadiazole-5,6-dicarboxylic imide is reported. The synthetic design allows for alkyl chains to be introduced on both electron-rich and electron-deficient components, which in turn allows for rapid optimization of the alkyl chain substitution pattern. Consequently, the optimized polymer shows a maximum efficiency of 8.3% in organic photovoltaic devices processed in commercially viable fashion without solvent additives, annealing, or device engineering.

2,1,3-benzothiadiazole-5,6-dicarboxylic imide - A versatile building block for additive- and annealing-free processing of organic solar cells with effi ciencies exceeding 8%

KAUST Repository

Nielsen, Christian Bergenstof; Ashraf, Raja Shahid; Treat, Neil D.; Schroeder, Bob C.; Donaghey, Jenny E.; White, Andrew J P; Stingelin, Natalie; McCulloch, Iain

2014-01-01

A new photoactive polymer comprising benzo[1,2-b:3,4-b′:5,6-d′]trithiophene and 2,1,3-benzothiadiazole-5,6-dicarboxylic imide is reported. The synthetic design allows for alkyl chains to be introduced on both electron-rich and electron-deficient components, which in turn allows for rapid optimization of the alkyl chain substitution pattern. Consequently, the optimized polymer shows a maximum efficiency of 8.3% in organic photovoltaic devices processed in commercially viable fashion without solvent additives, annealing, or device engineering.

Lead Poisoning

Science.gov (United States)

Lead is a metal that occurs naturally in the earth's crust. Lead can be found in all parts of our ... from human activities such as mining and manufacturing. Lead used to be in paint; older houses may ...

Quantitative importance of the pentose phosphate pathway determined by incorporation of 13C from [2-13C]- and [3-13C]glucose into TCA cycle intermediates and neurotransmitter amino acids in functionally intact neurons

DEFF Research Database (Denmark)

Brekke, Eva Marie; Walls, Anne Byriel; Schousboe, Arne

2012-01-01

is known about the PPP in neurons. The activity of the PPP was quantified in cultured cerebral cortical and cerebellar neurons after incubation in the presence of [2-(13)C]glucose or [3-(13)C]glucose. The activity of the PPP was several fold lower than glycolysis in both types of neurons. While metabolism...

Damage characterization of an ASTM A 213 grade 91 tube after 116.000 h of service in a reforming plant

International Nuclear Information System (INIS)

Tonti, Andrea; Lega, Daniela; Antonini, Alessandra; Romitelli, Manuela; Alvino, Antonello

2015-01-01

ASTM A213 T91 steel is used in power plants and petrochemical industry, for long-term service components. The improved mechanical properties of grade 91 are strictly related to its specific microstructure: a tempered martensite matrix with fine precipitates embedded in. Despite low alloy heat resistant ferritic steels, that have a well known operational experience, T91 service performances are still faintly consolidated, because this material has serviced only in a limited number of plants, since the eighties. Most of the available data were obtained by laboratory tests on relatively short term creep strength and corrosion properties. The investigations reported in this paper represent an important opportunity to describe and better evaluate the damage evolution of the grade T91 steel after more than 100000 h of exposure in severe conditions (580 °C, 18–26 bar, combustion environment). Our results suggest that the steel suffered by different damage forms, which appear on definite portions of the tube cross section. The main degradation forms observed, in fact, into the tube bulk are both the martensite recovery and the microstructural evolution. This latter promoted mostly Laves phase precipitation and coarsening. On the other hand, both the outer and the inner wall side, suffered mainly by severe oxidation/carburization. Especially on the outer surface, the massive carbide precipitation has caused an evident loss of ductility so that the mechanical properties of the tube appear appreciably reduced. - Highlights: • ASTM A213 T91 steel is used in petrochemical industry, for long-term service components. • The investigations reported an evaluation of the damage evolution of the grade T91 steel. • Our results suggest that the steel suffered both the martensite recovery and the microstructural evolution. • The outer and the inner wall side, suffered mainly by severe oxidation/carburization. • Carbide precipitation caused loss of ductility so that the

SPECTROSCOPIC CONFIRMATION OF THREE z-DROPOUT GALAXIES AT z = 6.844-7.213: DEMOGRAPHICS OF Lyα EMISSION IN z ∼ 7 GALAXIES

International Nuclear Information System (INIS)

Ono, Yoshiaki; Shimasaku, Kazuhiro; Nakajima, Kimihiko; Ouchi, Masami; Mobasher, Bahram; Nayyeri, Hooshang; Dickinson, Mark; Kartaltepe, Jeyhan S.; Penner, Kyle; Weiner, Benjamin J.; Stern, Daniel; Kashikawa, Nobunari; Spinrad, Hyron

2012-01-01

We present the results of our ultra-deep Keck/DEIMOS spectroscopy of z-dropout galaxies in the Subaru Deep Field and Great Observatories Origins Deep Survey's northern field. For 3 out of 11 objects, we detect an emission line at ∼1 μm with a signal-to-noise ratio of ∼10. The lines show asymmetric profiles with high weighted skewness values, consistent with being Lyα, yielding redshifts of z = 7.213, 6.965, and 6.844. Specifically, we confirm the z = 7.213 object in two independent DEIMOS runs with different spectroscopic configurations. The z = 6.965 object is a known Lyα emitter, IOK-1, for which our improved spectrum at a higher resolution yields a robust skewness measurement. The three z-dropouts have Lyα fluxes of 3 × 10 –17 erg s –1 cm –2 and rest-frame equivalent widths EW Lyα 0 = 33-43 Å. Based on the largest spectroscopic sample of 43 z-dropouts, which is the combination of our and previous data, we find that the fraction of Lyα-emitting galaxies (EW Lyα 0 > 25 Å) is low at z ∼ 7; 17% ± 10% and 24% ± 12% for bright (M UV ≅ –21) and faint (M UV ≅ –19.5) galaxies, respectively. The fractions of Lyα-emitting galaxies drop from z ∼ 6 to 7 and the amplitude of the drop is larger for faint galaxies than for bright galaxies. These two pieces of evidence would indicate that the neutral hydrogen fraction of the intergalactic medium increases from z ∼ 6 to 7 and that the reionization proceeds from high- to low-density environments, as suggested by an inside-out reionization model.

SPECTROSCOPIC CONFIRMATION OF THREE z-DROPOUT GALAXIES AT z = 6.844-7.213: DEMOGRAPHICS OF Ly{alpha} EMISSION IN z {approx} 7 GALAXIES

Energy Technology Data Exchange (ETDEWEB)

Ono, Yoshiaki; Shimasaku, Kazuhiro; Nakajima, Kimihiko, E-mail: ono@astron.s.u-tokyo.ac.jp [Department of Astronomy, Graduate School of Science, University of Tokyo, Tokyo 113-0033 (Japan); Ouchi, Masami [Institute for Cosmic Ray Research, University of Tokyo, Kashiwa 277-8582 (Japan); Mobasher, Bahram; Nayyeri, Hooshang [Department of Physics and Astronomy, University of California, Riverside, CA 92521 (United States); Dickinson, Mark; Kartaltepe, Jeyhan S. [National Optical Astronomical Observatories, Tucson, AZ 85719 (United States); Penner, Kyle [Department of Astronomy, University of Arizona, Tucson, AZ 85721 (United States); Weiner, Benjamin J. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Stern, Daniel [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Kashikawa, Nobunari [Optical and Infrared Astronomy Division, National Astronomical Observatory of Japan, Tokyo 181-8588 (Japan); Spinrad, Hyron [Department of Astronomy, University of California, Berkeley, CA 94720 (United States)

2012-01-10

We present the results of our ultra-deep Keck/DEIMOS spectroscopy of z-dropout galaxies in the Subaru Deep Field and Great Observatories Origins Deep Survey's northern field. For 3 out of 11 objects, we detect an emission line at {approx}1 {mu}m with a signal-to-noise ratio of {approx}10. The lines show asymmetric profiles with high weighted skewness values, consistent with being Ly{alpha}, yielding redshifts of z = 7.213, 6.965, and 6.844. Specifically, we confirm the z = 7.213 object in two independent DEIMOS runs with different spectroscopic configurations. The z = 6.965 object is a known Ly{alpha} emitter, IOK-1, for which our improved spectrum at a higher resolution yields a robust skewness measurement. The three z-dropouts have Ly{alpha} fluxes of 3 Multiplication-Sign 10{sup -17} erg s{sup -1} cm{sup -2} and rest-frame equivalent widths EW{sup Ly{alpha}}{sub 0} = 33-43 A. Based on the largest spectroscopic sample of 43 z-dropouts, which is the combination of our and previous data, we find that the fraction of Ly{alpha}-emitting galaxies (EW{sup Ly{alpha}}{sub 0} > 25 A) is low at z {approx} 7; 17% {+-} 10% and 24% {+-} 12% for bright (M{sub UV} {approx_equal} -21) and faint (M{sub UV} {approx_equal} -19.5) galaxies, respectively. The fractions of Ly{alpha}-emitting galaxies drop from z {approx} 6 to 7 and the amplitude of the drop is larger for faint galaxies than for bright galaxies. These two pieces of evidence would indicate that the neutral hydrogen fraction of the intergalactic medium increases from z {approx} 6 to 7 and that the reionization proceeds from high- to low-density environments, as suggested by an inside-out reionization model.

Lead Test

Science.gov (United States)

... to do renovation and repair projects using lead-safe work practices to avoid creating more lead dust or ... in a dangerous area? Yes. If you are working in a potentially harmful environment with exposure to lead dust or fumes: Wash ...

Determination of the neutron detection efficiency of an NE213 scintillator for En=2.5 to 16 MeV using the 2H(d,n)3He reaction

International Nuclear Information System (INIS)

Al-Ohali, M.A.; Aksoy, A.; Coban, A.

1997-01-01

The absolute efficiency of an NE213 liquid scintillator of 12.7 cm diameter and 5.08 cm thickness was measured in the neutron energy range 2.5-16 MeV using the 2 H(d,n) 3 He reaction as a source of monoenergetic neutrons. The efficiencies were measured at the time-of-flight facility of Triangle Universities Nuclear Laboratory TUNL. The experimental data are compared to calculations from the Monte Carlo code NEFF of Physikalisch-Technische Bundesanstalt, Braunschweig, Germany PTB. (orig.)

Bulk diffusion and solubility of silver and nickel in lead, lead-silver and lead-nickel solid solutions

International Nuclear Information System (INIS)

Amenzou-Badrour, H.; Moya, G.; Bernardini, J.

1988-01-01

The results of a study of solubility and bulk diffusion of /sup 110/Ag and /sup 63/Ni in lead, lead-silver and lead-nickel solid solutions in the temperature range 220 to 88 0 C are reported. Owing to the low solubility of silver and nickel in lead, Fick's solution corresponding to the boundary condition of a constant concentration of solute at the surface has been used. Depth profile concentration analysis suggests a fundamental difference between the diffusion mechanisms of silver and nickel. Since silver penetration profiles in pure lead give diffusion coefficients independent of the penetration depth and silver concentration, it is suggested that slight decreases of silver diffusivity in lead-silver solid solutions have no significance. This implies that the interstitial silver atoms do not associate significantly with each other to form Ag-Ag dimers. In contrast, different behaviors of /sup 63/Ni depth profile concentration in pure lead and saturated PbNi solid solutions agree with a Ni-Ni interaction leading to the formation of less mobile dimers near the surface in pure lead

A randomised double-blind clinical trial of two yellow fever vaccines prepared with substrains 17DD and 17D-213/77 in children nine-23 months old.

Science.gov (United States)

2015-09-01

This randomised, double-blind, multicentre study with children nine-23 months old evaluated the immunogenicity of yellow fever (YF) vaccines prepared with substrains 17DD and 17D-213/77. YF antibodies were titered before and 30 or more days after vaccination. Seropositivity and seroconversion were analysed according to the maternal serological status and the collaborating centre. A total of 1,966 children were randomised in the municipalities of the states of Mato Grosso do Sul, Minas Gerais and São Paulo and blood samples were collected from 1,714 mothers. Seropositivity was observed in 78.6% of mothers and 8.9% of children before vaccination. After vaccination, seropositivity rates of 81.9% and 83.2%, seroconversion rates of 84.8% and 85.8% and rates of a four-fold increase over the pre-vaccination titre of 77.6% and 81.8% were observed in the 17D-213/77 and 17DD subgroups, respectively. There was no association with maternal immunity. Among children aged 12 months or older, the seroconversion rates of 69% were associated with concomitant vaccination against measles, mumps and rubella. The data were not conclusive regarding the interference of maternal immunity in the immune response to the YF vaccine, but they suggest interference from other vaccines. The failures in seroconversion after vaccination support the recommendation of a booster dose in children within 10 years of the first dose.

A randomised double-blind clinical trial of two yellow fever vaccines prepared with substrains 17DD and 17D-213/77 in children nine-23 months old

Directory of Open Access Journals (Sweden)

2015-09-01

Full Text Available This randomised, double-blind, multicentre study with children nine-23 months old evaluated the immunogenicity of yellow fever (YF vaccines prepared with substrains 17DD and 17D-213/77. YF antibodies were tittered before and 30 or more days after vaccination. Seropositivity and seroconversion were analysed according to the maternal serological status and the collaborating centre. A total of 1,966 children were randomised in the municipalities of the states of Mato Grosso do Sul, Minas Gerais and São Paulo and blood samples were collected from 1,714 mothers. Seropositivity was observed in 78.6% of mothers and 8.9% of children before vaccination. After vaccination, seropositivity rates of 81.9% and 83.2%, seroconversion rates of 84.8% and 85.8% and rates of a four-fold increase over the pre-vaccination titre of 77.6% and 81.8% were observed in the 17D-213/77 and 17DD subgroups, respectively. There was no association with maternal immunity. Among children aged 12 months or older, the seroconversion rates of 69% were associated with concomitant vaccination against measles, mumps and rubella. The data were not conclusive regarding the interference of maternal immunity in the immune response to the YF vaccine, but they suggest interference from other vaccines. The failures in seroconversion after vaccination support the recommendation of a booster dose in children within 10 years of the first dose.

Electrical properties of a novel lead alkoxide precursor: Lead glycolate

International Nuclear Information System (INIS)

Tangboriboon, Nuchnapa; Pakdeewanishsukho, Kittikhun; Jamieson, Alexander; Sirivat, Anuvat; Wongkasemjit, Sujitra

2006-01-01

The reaction of lead acetate trihydrate Pb(CH 3 COO) 2 .3H 2 O and ethylene glycol, using triethylenetetramine (TETA) as a catalyst, provides in one step access to a polymer-like precursor of lead glycolate [-PbOCH 2 CH 2 O-]. On the basis of high-resolution mass spectroscopy, chemical analysis composition, FTIR, 13 C-solid state NMR and TGA, the lead glycolate precursor can be identified as a trimer structure. The FTIR spectrum demonstrates the characteristics of lead glycolate; the peaks at 1086 and 1042 cm -1 can be assigned to the C-O-Pb stretchings. The 13 C-solid state NMR spectrum gives notably only one peak at 68.639 ppm belonging to the ethylene glycol ligand. The phase transformations of lead glycolate and lead acetate trihydrate to lead oxide, their microstructures, and electrical properties were found to vary with increasing temperature. The lead glycolate precursor has superior electrical properties relative to those of lead acetate trihydrate, suggesting that the lead glycolate precursor can possibly be used as a starting material for producing electrical and semiconducting ceramics, viz. ferroelectric, anti-ferroelectric, and piezoelectric materials

Relational Leading

DEFF Research Database (Denmark)

Larsen, Mette Vinther; Rasmussen, Jørgen Gulddahl

2015-01-01

This first chapter presents the exploratory and curious approach to leading as relational processes – an approach that pervades the entire book. We explore leading from a perspective that emphasises the unpredictable challenges and triviality of everyday life, which we consider an interesting......, relevant and realistic way to examine leading. The chapter brings up a number of concepts and contexts as formulated by researchers within the field, and in this way seeks to construct a first understanding of relational leading....

CFD evaluation of hydrogen risk mitigation measures in a VVER-440/213 containment

Energy Technology Data Exchange (ETDEWEB)

Heitsch, Matthias, E-mail: Matthias.Heitsch@ec.europa.e [Institute for Energy, Joint Research Centre, PO Box 2, 1755 ZG Petten (Netherlands); Huhtanen, Risto [VTT Technical Research Centre of Finland, PO Box 1000, FI-02044 VTT (Finland); Techy, Zsolt [VEIKI Institute for Electric Power Research Co., PO Box 80, H-1251 Budapest (Hungary); Fry, Chris [Serco, Winfrith Technology Centre, Dorchester, Dorset DT2 8DH (United Kingdom); Kostka, Pal [VEIKI Institute for Electric Power Research Co., PO Box 80, H-1251 Budapest (Hungary); Niemi, Jarto [VTT Technical Research Centre of Finland, PO Box 1000, FI-02044 VTT (Finland); Schramm, Berthold [Gesellschaft fuer Anlagen- und Reaktorsicherheit, GRS mbH, Schwertnergasse 1, 50667 Koeln (Germany)

2010-02-15

In the PHARE project 'Hydrogen Management for the VVER440/213' (HU2002/000-632-04-01), CFD (Computational Fluid Dynamics) calculations using GASFLOW, FLUENT and CFX were performed for the Paks NPP (Nuclear Power Plant), modelling a defined severe accident scenario which involves the release of hydrogen. The purpose of this work is to demonstrate that CFD codes can be used to model gas movement inside a containment during a severe accident. With growing experience in performing such analyses, the results encourage the use of CFD in assessing the risk of losing containment integrity as a result of hydrogen deflagrations. As an effective mitigation measure in such a situation, the implementation of catalytic recombiners is planned in the Paks NPP. In order to support these plans both unmitigated and recombiner-mitigated simulations were performed. These are described and selected results are compared. The codes CFX and FLUENT needed refinement to their models of wall and bulk steam condensation in order to be able to fully simulate the severe accident under consideration. Several CFD codes were used in parallel to model the same accident scenario in order to reduce uncertainties in the results. Previously it was considered impractical to use CFD codes to simulate a full containment subject to a severe accident extending over many hours. This was because of the expected prohibitive computing times and missing physical capabilities of the codes. This work demonstrates that, because of developments in the capabilities of CFD codes and improvements in computer power, these calculations have now become feasible.

Correlation between some parameters of lead absorption and lead intoxication

Science.gov (United States)

Waldron, H. A.

1971-01-01

Waldron, H. A. (1971).Brit. J. industr. Med.,28, 195-199. Correlation between some parameters of lead absorption and lead intoxication. Use has been made of data collected over a number of years from workers exposed to a lead hazard in a motor-car factory. The correlations between various parameters of lead absorption and lead intoxication were computed, including blood and urine lead concentrations, urinary coproporphyrin, ALA and PBG concentrations, and haemoglobin concentration. In all, 15 correlation coefficients were calculated, of which only six showed a statistically significant result (i.e., Plead and urine lead (r = 0·38, Plead and coproporphyrin (r = 0·42, Plead and ALA (r = 0·43, Plead and PBG (r = 0·19, P<0·05). PMID:5572689

A novel description of a syndrome consisting of 7q21.3 deletion including DYNC1I1 with preserved DLX5/6 without ectrodactyly: a case report

OpenAIRE

Ramos-Zald?var, H?ctor M.; Mart?nez-Ir?as, Daniel G.; Espinoza-Moreno, Nelson A.; Napky-Rajo, Jos? S.; Bueso-Aguilar, Tulio A.; Reyes-Perdomo, Karla G.; Montes-Gambarelli, Jimena A.; Euceda, Isis M.; Ponce-Barahona, Aldo F.; G?mez-Fern?ndez, Carlos A.; Moncada-Arita, Wilberg A.; Palomo-Berm?dez, Victoria A.; Jim?nez-Faraj, Julia E.; Hern?ndez-Padilla, Amanda G.; Olivera, Denys A.

2016-01-01

Background Chromosomal region 7q21.3 comprises approximately 5.2 mega base pairs that include genes DLX5/6, SHFM1, and DYNC1I1 associated with split hand/split foot malformation 1. So far, there are reports of eight families with deletion of DYNC1I1 and preserved DLX5/6 associated with ectrodactyly. From these families, only three patients did not present ectrodactyly and, unlike our patient, no other cases have been described as having craniofacial dysmorphology, mitral valve prolapse, kypho...

The identification of lead ammunition as a source of lead exposure in First Nations: The use of lead isotope ratios

International Nuclear Information System (INIS)

Tsuji, Leonard J.S.; Wainman, Bruce C.; Martin, Ian D.; Sutherland, Celine; Weber, Jean-Philippe; Dumas, Pierre; Nieboer, Evert

2008-01-01

The use of lead shotshell to hunt water birds has been associated with lead-contamination in game meat. However, evidence illustrating that lead shotshell is a source of lead exposure in subsistence hunting groups cannot be deemed definitive. This study seeks to determine whether lead shotshell constitutes a source of lead exposure using lead isotope ratios. We examined stable lead isotope ratios for lichens, lead shotshell and bullets, and blood from residents of Fort Albany and Kashechewan First Nations, and the City of Hamilton, Ontario, Canada. Data were analyzed using ANOVA and regression analyses. ANOVA of isotope ratios for blood revealed significant differences with respect to location, but not sex. Hamilton differed from both Kashechewan and Fort Albany; however, the First Nations did not differ from each other. ANOVA of the isotope ratios for lead ammunition and lichens revealed no significant differences between lichen groups (north and south) and for the lead ammunition sources (pellets and bullets). A plot of 206 Pb/ 204 Pb and 206 Pb/ 207 Pb values illustrated that lichens and lead ammunition were distinct groupings and only the 95% confidence ellipse of the First Nations group overlapped that of lead ammunition. In addition, partial correlations between blood-lead levels (adjusted for age) and isotope ratios revealed significant (p 206 Pb/ 204 Pb and 206 Pb/ 207 Pb, and a significant negative correlation for 208 Pb/ 206 Pb, as predicted if leaded ammunition were the source of lead exposure. In conclusion, lead ammunition was identified as a source of lead exposure for First Nations people; however, the isotope ratios for lead shotshell pellets and bullets were indistinguishable. Thus, lead-contaminated meat from game harvested with lead bullets may also be contributing to the lead body burden

Effect on blood lead of airborne lead particles characterized by size.

Science.gov (United States)

Park, Dong-Uk; Paik, Nam-Won

2002-03-01

Worker exposure to airborne lead particles was evaluated for a total of 117 workers in 12 work-places of four different industrial types in Korea. The particle sizes were measured using 8-stage cascade impactors worn by the workers. Mass median aerodynamic diameters (MMAD) were determined by type of industry and percentage of lead particles as a fraction of airborne lead (PbA) concentration was determined by particle size. Blood lead (PbB) levels of workers who matched airborne lead samples were also examined. A Scheffé's pairwise comparison test showed that MMAD and the fractions of each of respirable particles and lead particles lead particles lead particles (r = 0.82) than that between concentrations of small particles and PbA (r = 0.61). A simple linear regression indicated that PbB correlated better with respirable lead concentration (r2 = 0.35, P = 0.0001) than with PbA concentration and had a higher slope coefficient. Controlling for respirable lead concentration reduced the partial correlation coefficient between PbA concentration and PbB level from 0.56 to 0.20 (P = 0.053). The results indicate that the contribution of respirable lead particles to lead absorption would be greater than that of PbA. This study concludes that the measurement of PbA only may not properly reflect a worker's exposure to lead particles with diverse characteristics. For the evaluation of a worker's exposure to various types of lead particles, it is recommended that respirable lead particles as well as PbA be measured.

Common ECG Lead Placement Errors. Part I: Limb Lead Reversals

Directory of Open Access Journals (Sweden)

Allison V. Rosen

2015-10-01

Full Text Available Background: Electrocardiography (ECG is a very useful diagnostic tool. However, errors in placement of ECG leads can create artifacts, mimic pathologies, and hinder proper ECG interpretation. It is important for members of the health care team to be able to recognize the common patterns resulting from lead placement errors. Methods: 12-lead ECGs were recorded in a single male healthy subject in his mid 20s. Six different limb lead reversals were compared to ECG recordings from correct lead placement. Results: Classic ECG patterns were observed when leads were reversed. Methods of discriminating these ECG patterns from true pathologic findings were described. Conclusion: Correct recording and interpretation of ECGs is key to providing optimal patient care. It is therefore crucial to be able to recognize common ECG patterns that are indicative of lead reversals.

LEADING WITH LEADING INDICATORS

International Nuclear Information System (INIS)

PREVETTE, S.S.

2005-01-01

This paper documents Fluor Hanford's use of Leading Indicators, management leadership, and statistical methodology in order to improve safe performance of work. By applying these methods, Fluor Hanford achieved a significant reduction in injury rates in 2003 and 2004, and the improvement continues today. The integration of data, leadership, and teamwork pays off with improved safety performance and credibility with the customer. The use of Statistical Process Control, Pareto Charts, and Systems Thinking and their effect on management decisions and employee involvement are discussed. Included are practical examples of choosing leading indicators. A statistically based color coded dashboard presentation system methodology is provided. These tools, management theories and methods, coupled with involved leadership and employee efforts, directly led to significant improvements in worker safety and health, and environmental protection and restoration at one of the nation's largest nuclear cleanup sites

Fast neutron and gamma-ray spectra measurements with a NE-213 spectrometer in the FNG Copper Benchmark Experiment

International Nuclear Information System (INIS)

Klix, Axel; Angelone, Maurizio; Fischer, Ulrich; Pillon, Mario

2016-01-01

Highlights: • Fast neutron and gamma-ray spectra were measured in a copper assembly irradiated with DT neutrons. • The results were compared with MCNP calculations. • Primary aim was to provide experimental data for checking and validation of nuclear data evaluations of copper. - Abstract: A neutronics benchmark experiment on a pure Copper assembly was performed at the Frascati Neutron Generator. The work aimed at testing of recent nuclear data libraries. This paper focuses on the measurement of fast neutron and gamma-ray flux spectra in the Copper assembly under DT neutron irradiation in two selected positions with a spectrometer based on the organic liquid scintillator NE-213. The measurement results were compared with Monte Carlo radiation transport calculations using MCNP and nuclear data from the JEFF-3.1.1 library. Calculations have been done with Cu data from JEFF-3.1.1, JEFF-3.2, FENDL-3 and ENDF/B-7.0. Discrepancies appear in the intermediate neutron energy range between experiment and calculation. Large discrepancies were observed in the gamma-ray spectra calculated with JEFF-3.2.

Fast neutron and gamma-ray spectra measurements with a NE-213 spectrometer in the FNG Copper Benchmark Experiment

Energy Technology Data Exchange (ETDEWEB)

Klix, Axel, E-mail: axel.klix@kit.edu [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Angelone, Maurizio [ENEA Dipartimento Fusione e Tecnologie per la Sicurezza Nucleare, C.R. Frascati, via E. Fermi 45, 00044 Frascati (Italy); Fischer, Ulrich [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Pillon, Mario [ENEA Dipartimento Fusione e Tecnologie per la Sicurezza Nucleare, C.R. Frascati, via E. Fermi 45, 00044 Frascati (Italy)

2016-11-01

Highlights: • Fast neutron and gamma-ray spectra were measured in a copper assembly irradiated with DT neutrons. • The results were compared with MCNP calculations. • Primary aim was to provide experimental data for checking and validation of nuclear data evaluations of copper. - Abstract: A neutronics benchmark experiment on a pure Copper assembly was performed at the Frascati Neutron Generator. The work aimed at testing of recent nuclear data libraries. This paper focuses on the measurement of fast neutron and gamma-ray flux spectra in the Copper assembly under DT neutron irradiation in two selected positions with a spectrometer based on the organic liquid scintillator NE-213. The measurement results were compared with Monte Carlo radiation transport calculations using MCNP and nuclear data from the JEFF-3.1.1 library. Calculations have been done with Cu data from JEFF-3.1.1, JEFF-3.2, FENDL-3 and ENDF/B-7.0. Discrepancies appear in the intermediate neutron energy range between experiment and calculation. Large discrepancies were observed in the gamma-ray spectra calculated with JEFF-3.2.

Secondary lead production

Energy Technology Data Exchange (ETDEWEB)

Hollis, R.G.

1990-10-16

This invention is concerned with the efficient recovery of soft lead from the paste component of used automobile lead-acid storage batteries. According to the invention, a scrap which contains lead oxide, lead sulfate, and antimony in an oxidized state is processed in the following steps to recover lead. A refractory lined reaction vessel is continuously charged with the scrap, along with a reductant effective for reducing lead oxide. The charged material is melted and agitated by means of a submerged lance at 900-1150{degree}C whereby some of the lead oxide of the scrap is reduced to form molten lead. A slag layer is then formed above the molten lead, and an amount of lead oxide is maintained in the slag layer. The molten lead, now containing under 0.5 wt % of antimony, is removed, and the antimony oxide in the scrap is concentrated as oxide in the slag layer. Preferred embodiments of the invention result in the production, in a single step, of a soft lead substantially free of antimony. The slag may be subsequently treated to reduce the antimony oxide and produce a valuable antimony-lead product. Further advantages of the process are that a wet battery paste may be used as the feed without prior drying, and the process can be conducted at a temperature 100-150{degree}C lower than in previously known methods. In addition, a smaller reactor can be employed which reduces both capital cost and fuel costs. The process of the invention is illustrated by descriptions of pilot plant tests. 1 fig.

Spectroscopic Confirmation of Three z-dropout Galaxies at z = 6.844-7.213: Demographics of Lyα Emission in z ~ 7 Galaxies

Science.gov (United States)

Ono, Yoshiaki; Ouchi, Masami; Mobasher, Bahram; Dickinson, Mark; Penner, Kyle; Shimasaku, Kazuhiro; Weiner, Benjamin J.; Kartaltepe, Jeyhan S.; Nakajima, Kimihiko; Nayyeri, Hooshang; Stern, Daniel; Kashikawa, Nobunari; Spinrad, Hyron

2012-01-01

We present the results of our ultra-deep Keck/DEIMOS spectroscopy of z-dropout galaxies in the Subaru Deep Field and Great Observatories Origins Deep Survey's northern field. For 3 out of 11 objects, we detect an emission line at ~1 μm with a signal-to-noise ratio of ~10. The lines show asymmetric profiles with high weighted skewness values, consistent with being Lyα, yielding redshifts of z = 7.213, 6.965, and 6.844. Specifically, we confirm the z = 7.213 object in two independent DEIMOS runs with different spectroscopic configurations. The z = 6.965 object is a known Lyα emitter, IOK-1, for which our improved spectrum at a higher resolution yields a robust skewness measurement. The three z-dropouts have Lyα fluxes of 3 × 10-17 erg s-1 cm-2 and rest-frame equivalent widths EWLyα 0 = 33-43 Å. Based on the largest spectroscopic sample of 43 z-dropouts, which is the combination of our and previous data, we find that the fraction of Lyα-emitting galaxies (EWLyα 0 > 25 Å) is low at z ~ 7; 17% ± 10% and 24% ± 12% for bright (M UV ~= -21) and faint (M UV ~= -19.5) galaxies, respectively. The fractions of Lyα-emitting galaxies drop from z ~ 6 to 7 and the amplitude of the drop is larger for faint galaxies than for bright galaxies. These two pieces of evidence would indicate that the neutral hydrogen fraction of the intergalactic medium increases from z ~ 6 to 7 and that the reionization proceeds from high- to low-density environments, as suggested by an inside-out reionization model. Based on data obtained with the Subaru Telescope and the W. M. Keck Observatory. The Subaru Telescope is operated by the National Astronomical Observatory of Japan. The W. M. Keck Observatory is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration.

Kinetics of oil saponification by lead salts in ancient preparations of pharmaceutical lead plasters and painting lead mediums.

Science.gov (United States)

Cotte, M; Checroun, E; Susini, J; Dumas, P; Tchoreloff, P; Besnard, M; Walter, Ph

2006-12-15

Lead soaps can be found in archaeological cosmetics as well as in oil paintings, as product of interactions of lead salts with oil. In this context, a better understanding of the formation of lead soaps allows a follow-up of the historical evolution of preparation recipes and provides new insights into conservation conditions. First, ancient recipes of both pharmaceutical lead plasters and painting lead mediums, mixtures of oil and lead salts, were reconstructed. The ester saponification by lead salts is determined by the preparation parameters which were quantified by FT-IR spectrometry. In particular, ATR/FT-IR spectrometer was calibrated by the standard addition method to quantitatively follow the kinetics of this reaction. The influence of different parameters such as temperature, presence of water and choice of lead salts was assessed: the saponification is clearly accelerated by water and heating. This analysis provides chemical explanations to the historical evolution of cosmetic and painting preparation recipes.

Lead levels - blood

Science.gov (United States)

Blood lead levels ... is used to screen people at risk for lead poisoning. This may include industrial workers and children ... also used to measure how well treatment for lead poisoning is working. Lead is common in the ...

Swift , XMM - Newton , and NuSTAR Observations of PSR J2032+4127/MT91 213

Energy Technology Data Exchange (ETDEWEB)

Li, K. L. [Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824 (United States); Kong, A. K. H. [Astrophysics, Department of Physics, University of Oxford, Keble Road, Oxford OX1 3RH (United Kingdom); Tam, P. H. T. [School of Physics and Astronomy, Sun Yat-sen University, Zhuhai 519082 (China); Hou, X. [Yunnan Observatories, Chinese Academy of Sciences, 396 Yangfangwang, Guandu District, Kunming 650216 (China); Takata, J. [Institute of Particle Physics and Astronomy, Huazhong University of Science and Technology (China); Hui, C. Y., E-mail: liliray@pa.msu.edu [Department of Astronomy and Space Science, Chungnam National University, Daejeon (Korea, Republic of)

2017-07-10

We report our recent Swift , NuSTAR , and XMM - Newton X-ray and Lijiang optical observations on PSR J2032+4127/MT91 213, the γ -ray binary candidate with a period of 45–50 years. The coming periastron of the system was predicted to be in 2017 November, around which high-energy flares from keV to TeV are expected. Recent studies with Chandra and Swift X-ray observations taken in 2015/2016 showed that its X-ray emission has been brighter by a factors of ∼10 than that before 2013, probably revealing some ongoing activities between the pulsar wind and the stellar wind. Our new Swift /XRT lightcurve shows no strong evidence of a single vigorous brightening trend, but rather several strong X-ray flares on weekly to monthly timescales with a slowly brightening baseline, namely the low state. The NuSTAR and XMM - Newton observations taken during the flaring and the low states, respectively, show a denser environment and a softer power-law index during the flaring state, implying that the pulsar wind interacted with the stronger stellar winds of the companion to produce the flares. These precursors would be crucial in studying the predicted giant outburst from this extreme γ -ray binary during the periastron passage in late 2017.

Lead and osteoporosis: Mobilization of lead from bone in postmenopausal women

Energy Technology Data Exchange (ETDEWEB)

Silbergeld, E.K. (Environmental Defense Fund, WA (USA)); Schwartz, J. (Environmental Protection Agency, Washington, DC (USA)); Mahaffey, K. (National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA))

1988-10-01

Although it has been known that humans accumulate lead in bone, mineralized tissue has been considered primarily as a sequestering compartment and not as a site of toxic action for lead. However, experimental data indicate that bone lead can be released during conditions of demineralization, such as pregnancy and lactation. We have examined lead status in women, before and after menopause, using the NHANES II dataset compiled between 1976 and 1980. In 2981 black and white women there was a highly significant increase in both whole blood and calculated plasma lead concentrations after menopause. The results indicate that bone lead is not an inert storage site for absorbed lead. Moreover, lead may interact with other factors in the course of postmenopausal osteoporosis, to aggravate the course of the disease, since lead is known to inhibit activation of vitamin D, uptake of dietary calcium, and several regulatory aspects of bone cell function. The consequences of this mobilization may also be of importance in assessing the risks of maternal lead exposure to fetal and infant health.

Safe leads and lead changes in competitive team sports

Science.gov (United States)

Clauset, A.; Kogan, M.; Redner, S.

2015-06-01

We investigate the time evolution of lead changes within individual games of competitive team sports. Exploiting ideas from the theory of random walks, the number of lead changes within a single game follows a Gaussian distribution. We show that the probability that the last lead change and the time of the largest lead size are governed by the same arcsine law, a bimodal distribution that diverges at the start and at the end of the game. We also determine the probability that a given lead is "safe" as a function of its size L and game time t . Our predictions generally agree with comprehensive data on more than 1.25 million scoring events in roughly 40 000 games across four professional or semiprofessional team sports, and are more accurate than popular heuristics currently used in sports analytics.

[Environmental lead poisoning from lead-glazed earthenware used for storing drinks].

Science.gov (United States)

Sabouraud, S; Coppéré, B; Rousseau, C; Testud, F; Pulce, C; Tholly, F; Blanc, M; Culoma, F; Facchin, A; Ninet, J; Chambon, P; Medina, B; Descotes, J

2009-12-01

Current unusual environmental sources of lead exposure mainly include traditional medicines, either ayurvedic remedies or others, traditional cosmetics (kohl, surma), and the use of traditional earthenware, for storage or cooking. We report two cases of lead poisoning in adults initially identified by paroxysmal abdominal pain or anemia. In both cases, the environmental investigation evidenced one main source of lead exposure, namely a lead-glazed earthenware jug in which a drink was stored, "kefir" in the first case, and "kombucha" tea in the second one. It is recommended to search for lead intoxication in patients with unexplained anemia. Environmental sources of lead can be multiple. Their relative importance has to be ranked during the environmental investigation and among these, lead-glazed earthenware must be considered as a source of high lead exposure when drinks are stored inside and thus can soak.

Lead pollution: lead content in milk from cows fed on contaminated forages

Energy Technology Data Exchange (ETDEWEB)

Sapetti, C; Arduino, E; Durio, P

1973-01-01

Lead toxicity is reviewed, and the history of the lead poisoning is described. Much of the lead pollution in soil is due to automobile exhaust. Two milk cows were fed forage with added lead acetate. The 20 kg of lead corresponded to 50 ppm, a level that is often found in hays near major highways. The cows milk was then analyzed for lead content. During the first and second phase of administration of lead salts, the milk cows did not show any evident symptoms of intoxication. The lead in the milk did have a marked correlation with the administered lead. The lead doses did not last long enough for chronic symptoms to begin. The dosage of lead in milk, due to the facility of drawing samples and the relevant levels of response, could represent a valid method for diagnosing incipient chronic intoxications.

Measurement of neutron energy spectra of PuO[sub 2]-UO[sub 2] mixed oxide fuel and penetrated through surrounding lead-acryl shield

Energy Technology Data Exchange (ETDEWEB)

Nakao, Noriaki; Tsujimura, Norio; Nakamura, Takashi (Tohoku Univ., Sendai (Japan). Cyclotron and Radioisotope Center); Momose, Takumaro; Ninomiya, Kazushige; Ishiguro; Hideharu

1993-12-01

The energy spectra of neutrons emitted from an aluminum can containing PuO[sub 2]-UO[sub 2] mixed oxide fuel and penetrated through a 35mm thick lead-acryl shield surrounding the can, were measured with the NE-213 organic liquid scintillator, the proton recoil proportional counter and the multi-moderator [sup 3]He spectrometer (Bonner Ball). The measured results were compared with the results calculated by the MORSE-CG Monte Carlo code on the basis of source neutron yields obtained by the ORIGEN-2 code and the source energy spectrum cited from the reference data. The agreement between these two was pretty good. The dose equivalents were then calculated from thus-obtained energy spectra and the flux-to-dose conversion factor and showed good agreement with the data measured with the neutron dose-equivalent counters (rem counters). Since the published data on energy spectrum of mixed oxide fuel are very scarce, these results can be useful as basic data for shielding design study and radiation control of nuclear fuel facilities. (author).

Effect measure modification of blood lead-air lead slope factors.

Science.gov (United States)

Richmond-Bryant, Jennifer; Meng, Qingyu; Cohen, Jonathan; Davis, J Allen; Svendsgaard, David; Brown, James S; Tuttle, Lauren; Hubbard, Heidi; Rice, Joann; Kirrane, Ellen; Vinikoor-Imler, Lisa; Kotchmar, Dennis; Hines, Erin; Ross, Mary

2015-01-01

There is abundant literature finding that susceptibility factors, including race and ethnicity, age, and housing, directly influence blood lead levels. No study has explored how susceptibility factors influence the blood lead-air lead relationship nationally. The objective is to evaluate whether susceptibility factors act as effect measure modifiers on the blood lead-air lead relationship. Participant level blood lead data from the 1999 to 2008 National Health and Nutrition Examination Survey were merged with air lead data from the US Environmental Protection Agency. Linear mixed effects models were run with and without an air lead interaction term for age group, sex, housing age, or race/ethnicity to determine whether these factors are effect measure modifiers for all ages combined and for five age brackets. Age group and race/ethnicity were determined to be effect measure modifiers in the all-age model and for some age groups. Being a child (1-5, 6-11, and 12-19 years) or of Mexican-American ethnicity increased the effect estimate. Living in older housing (built before 1950) decreased the effect estimate for all models except for the 1-5-year group, where older housing was an effect measure modifier. These results are consistent with the peer-reviewed literature of time-activity patterns, ventilation, and toxicokinetics.

Lead - nutritional considerations

Science.gov (United States)

... billion people had toxic (poisonous) blood lead levels. Food Sources Lead can be found in canned goods if there is lead solder in the ... to bottled water for drinking and cooking. Avoid canned goods from foreign ... cans goes into effect. If imported wine containers have a lead foil ...

The refining of secondary lead for use in advanced lead-acid batteries

International Nuclear Information System (INIS)

Ellis, Timothy W.; Mirza, Abbas H.

2010-01-01

Secondary lead, i.e. material produced by the recycling of lead-acid batteries has become the primary source of lead in much of the world. This has been important to the secondary lead industry as other uses have dwindled, e.g. lead based pigments, chemicals, fuel additives, solders and CRT glasses. Presently, battery manufacturing accounts for greater than 80% of lead consumption while recycled lead accounts for approximately the same market share of lead supply. These two facts strongly demonstrate the battery manufacturing and recycled lead are intimately coupled in everyday life. In this paper we will explore how recycled lead has become the material of choice for battery construction through the development of a recovery and refining process that exceeds the industries requirements. Particular focus will be on addressing the results presented by Prengaman on the effects of contaminant or tramp elements on gassing in lead-acid batteries. (author)

The effect of lead-based paint hazard remediation on blood lead levels of lead poisoned children in New York City.

Science.gov (United States)

Leighton, Jessica; Klitzman, Susan; Sedlar, Slavenka; Matte, Thomas; Cohen, Neal L

2003-07-01

Despite the widespread use of lead paint hazard control for children with lead poisoning, few controlled studies that estimate the effect of such control on children's blood lead levels have been published. This retrospective follow-up study examined the effects of lead hazard remediation and its timing on the blood lead levels of lead-poisoned children. From the New York City child blood lead registry, 221 children were selected who had an initial blood lead level of 20-44 micro g/dL between 1 July 1994 and 31 December 1996; were 6 months to 6 years of age; had a report of a follow-up blood lead test between 10 and 14 months after the initial test; had a lead-based paint hazard identified in the primary dwelling unit prior to the 10- to 14-month follow-up blood lead test; had resided or spent time at only one address with an identified lead-based paint hazard; and were not chelated. The decline in geometric mean blood lead levels from baseline to 10-14 months later was compared for children whose homes were remediated and whose homes were not remediated during the follow-up period. Regardless of remediation, geometric mean blood lead levels declined significantly from 24.3 micro g/dL at the initial diagnosis to 12.3 micro g/dL at the 10- to 14-month follow-up blood lead test (Premediated the geometric mean blood lead levels declined 53% compared to 41% among the 75 children whose homes were not remediated by the follow-up blood lead test, a remediation effect of approximately 20% (Premediation effect was 11%, although it was no longer significant. Race was the only factor that appeared to confound the relationship: Black children had higher follow-up blood lead levels even after controlling for other factors, including the natural logarithm of the initial blood lead level. The effect of remediation appeared to be stronger for younger (10 to remediation (within less than 3 months) appeared to have greater declines in blood lead levels at the follow-up test than

Final report of effect of irradiation on microstructure and mechanical properties on copper and copper alloys. (ITER R and D Task No. T13 and T213)

International Nuclear Information System (INIS)

Singh, B.N.

1998-04-01

The present note is the final report on investigations carried out under ITER Task No. T13 EU (1994). Most of the results of these investigations have been published in the open literature either as articles or reports. A list of the appropriate references are given. Results that have been presented at various meetings but have not been published are summarized in the present document. In addition, the present report also clarifies the status of the deliverables in the ITER Task No. T213 (EU (1995). Finally, the main conclusions emerging from these investigations are highlighted. (au)

Clinical Observation on Termination of Early Pregnancy of 213 Cases after Caesarian Section with Repeated Use of Mifepristone and Misoprostol

Institute of Scientific and Technical Information of China (English)

高佩佩; 汪平

1999-01-01

Objective To investigate the efficacy and safety in women after caesarian section for termination of early pregnancies by treatment, or repeated treatment with mifepristone and misoprostot.Subjects and Methods A total of 213 pregnant women with amenorrhea of 34-69d after caesarian section who asked for medical abortion were recruited,including 63 cases undergoing their second medical abortion.A total amount of mi feprisstone of 150 mg given in separate doses(25 mg×4 and 50 mg at the first time)was administered orally within 3d, followed by misoprostot of 0.6 mg orally in the morning of d 3.Results The complete abortion rate was 92.5%,incomplete abortion was 4.7% and failure was 2.8%.Conclusion The sequential use of mifepristone and misoprostol could be successfully and repeatedly used for induced abortion in those women with a caesarian section histo-ry.Its efficacy was similar to that for ordinary population.Its safety and effec-tiveness were satisfactory.

Melatonin reduces lead levels in blood, brain and bone and increases lead excretion in rats subjected to subacute lead treatment.

Science.gov (United States)

Hernández-Plata, Everardo; Quiroz-Compeán, Fátima; Ramírez-Garcia, Gonzalo; Barrientos, Eunice Yáñez; Rodríguez-Morales, Nadia M; Flores, Alberto; Wrobel, Katarzina; Wrobel, Kazimierz; Méndez, Isabel; Díaz-Muñoz, Mauricio; Robles, Juvencio; Martínez-Alfaro, Minerva

2015-03-04

Melatonin, a hormone known for its effects on free radical scavenging and antioxidant activity, can reduce lead toxicity in vivo and in vitro.We examined the effects of melatonin on lead bio-distribution. Rats were intraperitoneally injected with lead acetate (10, 15 or 20mg/kg/day) with or without melatonin (10mg/kg/day) daily for 10 days. In rats intoxicated with the highest lead doses, those treated with melatonin had lower lead levels in blood and higher levels in urine and feces than those treated with lead alone, suggesting that melatonin increases lead excretion. To explore the mechanism underlying this effect, we first assessed whether lead/melatonin complexes were formed directly. Electronic density functional (DFT) calculations showed that a lead/melatonin complex is energetically feasible; however, UV spectroscopy and NMR analysis showed no evidence of such complexes. Next, we examined the liver mRNA levels of metallothioneins (MT) 1 and 2. Melatonin cotreatment increased the MT2 mRNA expression in the liver of rats that received the highest doses of lead. The potential effects of MTs on the tissue distribution and excretion of lead are not well understood. This is the first report to suggest that melatonin directly affects lead levels in organisms exposed to subacute lead intoxication. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Lead elimination by ICRF 158 in rats after chronic lead exposure

Energy Technology Data Exchange (ETDEWEB)

Witting, U; Hultsch, E

1981-02-01

Lead elimination by ICRF 158, a lipophilic derivative of ethylene-diaminetetra-acetate (EDTA), was investigated in rats after chronic lead exposure. The animals had received a lead concentration of 550 ppm in their drinking water for 140 days. Subsequent treatment with ICRF 158 for 30 days led to increased mobilization and elimination of incorporated lead, and the lead-induced inhibition of hemosynthesis was removed. ICR 158 produced no renal damage in excess to lead-induced tubular nephrosis. Separate toxicity tests in mice demonstrated that is less toxic than CaNa/sub 2/EDTA. ICRF 158 does not form stable complexes with lead ions in vitro. The mechanism of action of this lipophilic EDTA derivative is compared to that of its hydrophilic correspondent, the chelating agent CaNa/sub 2/EDTA.

Cryogenic current leads

Energy Technology Data Exchange (ETDEWEB)

Zizek, F.

1982-01-01

Theoretical, technical and design questions are examined of cryogenic current leads for SP of magnetic systems. Simplified mathematical models are presented for the current leads. To illustrate modeling, the calculation is made of the real current leads for 500 A and three variants of current leads for 1500 A for the enterprise ''Shkoda.''

The effect of lead-based paint hazard remediation on blood lead levels of lead poisoned children in New York City

International Nuclear Information System (INIS)

Leighton, Jessica; Klitzman, Susan; Sedlar, Slavenka; Matte, Thomas; Cohen, Neal L.

2003-01-01

Despite the widespread use of lead paint hazard control for children with lead poisoning, few controlled studies that estimate the effect of such control on children's blood lead levels have been published. This retrospective follow-up study examined the effects of lead hazard remediation and its timing on the blood lead levels of lead-poisoned children. From the New York City child blood lead registry, 221 children were selected who had an initial blood lead level of 20-44 μg/dL between 1 July 1994 and 31 December 1996; were 6 months to 6 years of age; had a report of a follow-up blood lead test between 10 and 14 months after the initial test; had a lead-based paint hazard identified in the primary dwelling unit prior to the 10- to 14-month follow-up blood lead test; had resided or spent time at only one address with an identified lead-based paint hazard; and were not chelated. The decline in geometric mean blood lead levels from baseline to 10-14 months later was compared for children whose homes were remediated and whose homes were not remediated during the follow-up period. Regardless of remediation, geometric mean blood lead levels declined significantly from 24.3 μg/dL at the initial diagnosis to 12.3 μg/dL at the 10- to 14-month follow-up blood lead test (P<0.01). Among the 146 children whose homes were remediated the geometric mean blood lead levels declined 53% compared to 41% among the 75 children whose homes were not remediated by the follow-up blood lead test, a remediation effect of approximately 20% (P<0.01). After adjusting for potential confounders, the remediation effect was 11%, although it was no longer significant. Race was the only factor that appeared to confound the relationship: Black children had higher follow-up blood lead levels even after controlling for other factors, including the natural logarithm of the initial blood lead level. The effect of remediation appeared to be stronger for younger (10 to <36 months old) than for older (36

Work function of oxygen exposed lead and lead/indium alloy films

International Nuclear Information System (INIS)

Gundlach, K.H.; Hellemann, H.P.; Hoelzl, J.

1982-01-01

The effect of indium in superconducting tunnel junctions with lead/indium alloy base electrodes is investigated by measuring the vacuum work function of lead, indium, and lead/indium alloy films. It is found that the anomalous decrease of the work function of lead upon exposure to oxygen, explained by the penetration of oxygen into the inner surface of the lead film, is reversed into a slight increase in work function when some indium is added to the lead. This result indicates that the addition of indium provides a protection by suppressing the penetration of oxygen (and probably other gases) into the interior of the thin film

Blood lead and lead-210 origins in residents of Toulouse

International Nuclear Information System (INIS)

Servant, J.; Delapart, M.

1981-01-01

Blood lead and lead-210 analyses were performed on blood samples from non-smoking residents of Toulouse (city of 400,000 inhabitants). Simultaneous surface soil lead content determinations were carried out by the same procedure on rural zone samples of southwestern France. The observed isotopic ratios were compared in order to evaluate food chain contamination. For an average of 19.7 +- 5.8 μg 100 cc -1 of lead in blood, atmospheric contamination amounts to 20%, estimated as follows: 6% from direct inhalation and 14% from dry deposits on vegetation absorbed as food. The natural levels carried over by the food chain reach 14.9 μg 100 cc -1 and have a 210 Pb/Pb concentration ratio of 0.055 dpmμg -1 . These results lead to a maximum value of 15 μg 100 cc -1 for natural lead in human blood according to the ICRP model. (author)

Lead-Free Piezoelectrics

CERN Document Server

Nahm, Sahn

2012-01-01

Ecological restrictions in many parts of the world are demanding the elimination of Pb from all consumer items. At this moment in the piezoelectric ceramics industry, there is no issue of more importance than the transition to lead-free materials. The goal of Lead-Free Piezoelectrics is to provide a comprehensive overview of the fundamentals and developments in the field of lead-free materials and products to leading researchers in the world. The text presents chapters on demonstrated applications of the lead-free materials, which will allow readers to conceptualize the present possibilities and will be useful for both students and professionals conducting research on ferroelectrics, piezoelectrics, smart materials, lead-free materials, and a variety of applications including sensors, actuators, ultrasonic transducers and energy harvesters.

Lead Toxicity

Science.gov (United States)

... o Do not use glazed ceramics, home remedies, cosmetics, or leaded-crystal glassware unless you know that they are lead safe. o If you live near an industry, mine, or waste site that may have contaminated ...

Aerial Photography and Imagery, Ortho-Corrected, This data set includes georectified, 4 -band digital orthophotos for 213.7 square miles of the Blackwater National Wildlife Refuge and Fishing Bay WMA in Dorchester County, MD., Published in 2010, 1:2400 (1in=200ft) scale, Eastern Shore Regional GIS Cooperative.

Data.gov (United States)

NSGIC Regional | GIS Inventory — Aerial Photography and Imagery, Ortho-Corrected dataset current as of 2010. This data set includes georectified, 4 -band digital orthophotos for 213.7 square miles...

The lead and lead-acid battery industries during 2002 and 2007 in China

Energy Technology Data Exchange (ETDEWEB)

Chen, H.Y.; Li, A.J.; Finlow, D.E. [Key Lab of Electrochemical Technology on Energy Storage and Power Generation in Guangdong Universities, School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China)

2009-06-01

In the past 15 years, the center of the international lead market has shifted to China. China has become the largest producer of raw and refined lead, plus the largest consumer. This paper reviews the status of the lead and lead-acid battery industries in China, including lead mining, lead refining, secondary lead production, the lead-acid battery industry, new opportunities for lead-acid batteries, and the environmental problems associated with lead and lead-acid batteries. The output of raw and refined lead has increased annually in China, and now accounts for more than 30% of the world total. As a result of a change in the Chinese government's policy regarding the export of lead, plus an increase in the price of lead, the profits of Chinese lead manufacturers were significantly reduced, the trade deficit of the Chinese lead industry increased, the operating rates of lead smelter enterprises greatly reduced, and some small enterprises were forced to shut down. At the present time, an increasing number of enterprises have begun to produce secondary lead, and the scale of production has expanded from tens of tons to tens of thousands of tons. In 2006, the output of secondary lead in China reached 700,000 tons, but outdated technology and equipment limited development of the secondary lead industry. Because of serious pollution problems, raw material shortages, and fierce price competition in the battery market, changes in the development of the lead-acid battery industry have been dramatic; approximately one thousand medium-sized and small lead-acid battery producers have been closed in the past 3 years. The output of large lead-acid battery enterprises has not been reduced, however, as a result of their manufacturing technology and equipment being comparable to those in other advanced industrial countries. In China, the flourishing development of electric bicycles, electric tricycles, and photovoltaic energy systems should provide ongoing opportunities for

The lead and lead-acid battery industries during 2002 and 2007 in China

International Nuclear Information System (INIS)

Chen, H.Y.; Li, A.J.; Finlow, D.E.

2009-01-01

In the past 15 years, the center of the international lead market has shifted to China. China has become the largest producer of raw and refined lead, plus the largest consumer. This paper reviews the status of the lead and lead-acid battery industries in China, including lead mining, lead refining, secondary lead production, the lead-acid battery industry, new opportunities for lead-acid batteries, and the environmental problems associated with lead and lead-acid batteries. The output of raw and refined lead has increased annually in China, and now accounts for more than 30% of the world total. As a result of a change in the Chinese government's policy regarding the export of lead, plus an increase in the price of lead, the profits of Chinese lead manufacturers were significantly reduced, the trade deficit of the Chinese lead industry increased, the operating rates of lead smelter enterprises greatly reduced, and some small enterprises were forced to shut down. At the present time, an increasing number of enterprises have begun to produce secondary lead, and the scale of production has expanded from tens of tons to tens of thousands of tons. In 2006, the output of secondary lead in China reached 700,000 tons, but outdated technology and equipment limited development of the secondary lead industry. Because of serious pollution problems, raw material shortages, and fierce price competition in the battery market, changes in the development of the lead-acid battery industry have been dramatic; approximately one thousand medium-sized and small lead-acid battery producers have been closed in the past 3 years. The output of large lead-acid battery enterprises has not been reduced, however, as a result of their manufacturing technology and equipment being comparable to those in other advanced industrial countries. In China, the flourishing development of electric bicycles, electric tricycles, and photovoltaic energy systems should provide ongoing opportunities for the

A green lead hydrometallurgical process based on a hydrogen-lead oxide fuel cell.

Science.gov (United States)

Pan, Junqing; Sun, Yanzhi; Li, Wei; Knight, James; Manthiram, Arumugam

2013-01-01

The automobile industry consumed 9 million metric tons of lead in 2012 for lead-acid batteries. Recycling lead from spent lead-acid batteries is not only related to the sustainable development of the lead industry, but also to the reduction of lead pollution in the environment. The existing lead pyrometallurgical processes have two main issues, toxic lead emission into the environment and high energy consumption; the developing hydrometallurgical processes have the disadvantages of high electricity consumption, use of toxic chemicals and severe corrosion of metallic components. Here we demonstrate a new green hydrometallurgical process to recover lead based on a hydrogen-lead oxide fuel cell. High-purity lead, along with electricity, is produced with only water as the by-product. It has a >99.5% lead yield, which is higher than that of the existing pyrometallurgical processes (95-97%). This greatly reduces lead pollution to the environment.

Lead Contamination and Microbial Lead Tolerance in Soils at Major ...

African Journals Online (AJOL)

Devika

ABSTRACT: Lead pollution and lead tolerance levels of microbes in soil at major road junctions in Benin. City were investigated. Results revealed that distance from the road junctions affected the concentrations of lead in soil, as well as the microbial population density and types of microbes present in the soil. The highest ...

Lead Contamination and Microbial Lead Tolerance in Soils at Major ...

African Journals Online (AJOL)

Lead pollution and lead tolerance levels of microbes in soil at major road junctions in Benin City were investigated. Results revealed that distance from the road junctions affected the concentrations of lead in soil, as well as the microbial population density and types of microbes present in the soil. The highest concentrations ...

Organic molecules based on dithienyl-2,1,3-benzothiadiazole as new donor materials for solution-processed organic photovoltaic cells

Energy Technology Data Exchange (ETDEWEB)

Wu, Zhonglian; Fan, Benhu; Ouyang, Jianyong [Department of Materials Science and Engineering, National University of Singapore, Singapore 117574 (Singapore); Xue, Feng [Department of Chemistry, National University of Singapore, Singapore 117573 (Singapore); Adachi, Chihaya [Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan)

2010-12-15

Polymers based on dithienyl-2,1,3-benzothiadiazole (TBT) have received strong attention as the donor materials of polymer photovoltaic cells (PVs), since they can have a low band gap. But soluble small organic molecules based on TBT have been rarely studied. This paper reports the synthesis of two small organic molecules based on TBT and their application as the donor materials of solution-processed bulk heterojunction organic photovoltaic cells (OPVs). These compounds were soluble in common organic solvents, such as chloroform, chlorobenzene and tetrahydrofuran. They have band gaps comparable to poly(3-hexylthiophene) (P3HT) and lower HOMO and LUMO (HOMO: highest occupied molecular orbital, LUMO: lowest unoccupied molecular orbital) levels than P3HT. These molecules and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) were used as the donors and acceptor to fabricate bulk heterojunction OPVs through solution processing. After optimization of the experimental conditions, power conversion efficiency (PCE) of 0.66% was achieved on the solution-processed OPVs under AM 1.5G, 100 mW cm{sup -2} illumination. (author)

The effects of thiamin on lead metabolism: organ distribution of lead 203.

Science.gov (United States)

Kim, J S; Hamilton, D L; Blakley, B R; Rousseaux, C G

1992-01-01

The effect of thiamin on the organ distribution of lead was evaluated in CD-1 mice exposed intragastrically or intraperitoneally to a single dose of lead acetate (100 micrograms) containing 100 microCi lead 203. They were treated with either thiamin (25 or 50 mg/kg body weight), calcium ethylenediaminetetraacetic acid (CaEDTA) (50 mg/kg body weight), or combinations of thiamin and CaEDTA. The whole body retention and the organ distribution of lead 203 varied depending upon the route of lead administration, dose of thiamin and the specific treatment combination. Thiamin (25 or 50 mg/kg) treatment increased the whole body retention of both intragastric and intraperitoneal lead by approximately 10% in each instance. Calcium ethylenediaminetetraacetic acid, either alone or in combination with thiamin (50 mg/kg) reduced the whole body retention of lead by as much as 14% regardless of route of lead exposure. The relative retention of lead by the liver, kidney and spleen was greater in mice exposed to lead by the intragastric route. Regardless of route, CaEDTA in the combined treatment reduced the relative retention of lead in both the liver and kidney, whereas thiamin alone only reduced the retention of lead in the kidney. The results of this study indicate that thiamin in combination with CaEDTA alters the distribution and retention of lead in a manner which may have therapeutic application as it relates to chelation therapy. PMID:1423063

Lead shot from hunting as a source of lead in human blood

International Nuclear Information System (INIS)

Johansen, Poul; Pedersen, Henning Sloth; Asmund, Gert; Riget, Frank

2006-01-01

This study investigates the relationship between the intake of birds hunted with lead shot and the lead concentration in human blood. Fifty adult men from Nuuk, Greenland took part in the study. From September 2003 to June 2004 they regularly gave blood samples and recorded how many birds they ate. We found a clear relationship between the number of bird meals and blood lead and also a clear seasonal variation. The concentration was highest in mid-winter when bird consumption is at its highest. Blood lead was low (15 μg/L, mean concentration) among the participants reporting not eating birds. Among those reporting to eat birds regularly, blood lead was significantly higher, up to 128 μg/L (mean concentration). Concentrations depended on the frequency of bird meals: the more the bird meals, the higher the resulting blood lead. This clear relationship points to lead shot as the dominating lead source to people in Greenland. - Birds hunted with lead shot and consumed are a source of lead in human blood

Lead shot from hunting as a source of lead in human blood

Energy Technology Data Exchange (ETDEWEB)

Johansen, Poul [National Environmental Research Institute, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)]. E-mail: poj@dmu.dk; Pedersen, Henning Sloth [Primary Health Care Center, DK-3900 Nuuk (Greenland); Asmund, Gert [National Environmental Research Institute, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Riget, Frank [National Environmental Research Institute, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)

2006-07-15

This study investigates the relationship between the intake of birds hunted with lead shot and the lead concentration in human blood. Fifty adult men from Nuuk, Greenland took part in the study. From September 2003 to June 2004 they regularly gave blood samples and recorded how many birds they ate. We found a clear relationship between the number of bird meals and blood lead and also a clear seasonal variation. The concentration was highest in mid-winter when bird consumption is at its highest. Blood lead was low (15 {mu}g/L, mean concentration) among the participants reporting not eating birds. Among those reporting to eat birds regularly, blood lead was significantly higher, up to 128 {mu}g/L (mean concentration). Concentrations depended on the frequency of bird meals: the more the bird meals, the higher the resulting blood lead. This clear relationship points to lead shot as the dominating lead source to people in Greenland. - Birds hunted with lead shot and consumed are a source of lead in human blood.

The leaching of lead from lead-based paint in landfill environments.

Science.gov (United States)

Wadanambi, Lakmini; Dubey, Brajesh; Townsend, Timothy

2008-08-30

Lead leaching from lead-based paint (LBP) was examined using standardized laboratory protocols and tests with leachate from actual and simulated landfill environments. Two different LBP samples were tested; leaching solutions included leachates from three municipal solid waste (MSW) landfills and three construction and demolition (C&D) debris landfills. The toxicity characteristic leaching procedure (TCLP) and the synthetic precipitation leaching procedure (SPLP) were also performed. Lead concentrations were many times higher using the TCLP compared to the SPLP and the landfill leachates. No significant difference (alpha=0.05) was observed in leached lead concentrations from the MSW landfill and C&D debris landfill leachates. The impact of other building materials present in LBP debris on lead leaching was examined by testing mixtures of LBP (2%) and different building materials (98%; steel, wood, drywall, concrete). The type of substrate present impacted lead leaching results, with concrete demonstrating the most dramatic impact; the lowest lead concentrations were measured in the presence of concrete under both TCLP and SPLP extractions.

Relationship between soil lead and airborne lead concentrations at Springfield, Missouri, USA

Energy Technology Data Exchange (ETDEWEB)

Sheets, R W; Kyger, J R; Biagioni, R N; Probst, S [Department of Chemistry, Southwest Missouri State University, 65804 Springfield, MO (United States); Boyer, R; Barke, K [Greene County Health Department, 65802 Springfield, MO (United States)

2001-04-23

This study tests whether lead deposited to soil from automobiles during past years in a medium-sized US city (population 150000) may present a current health risk. It examines the relationship between current soil lead concentrations at nine locations within the city of Springfield, Missouri, and airborne lead levels measured at the same locations during years (1975-1981) when lead emissions from automobiles were much greater than at present. A strong, significant correlation is found between soil and airborne lead levels at eight of the sites (r=0.91, P<0.005 for soil lead vs. 1979 airborne lead), in low-traffic areas as well as in areas adjacent to heavy traffic flow. Residual lead concentrations in these soils are relatively low, even for the high-traffic sites, as expected for a medium sized city.

Corrosion by liquid lead and lead-bismuth: experimental results review and analysis

Energy Technology Data Exchange (ETDEWEB)

Zhang, Jinsuo [Los Alamos National Laboratory

2008-01-01

Liquid metal technologies for liquid lead and lead-bismuth alloy are under wide investigation and development for advanced nuclear energy systems and waste transmutation systems. Material corrosion is one of the main issues studied a lot recently in the development of the liquid metal technology. This study reviews corrosion by liquid lead and lead bismuth, including the corrosion mechanisms, corrosion inhibitor and the formation of the protective oxide layer. The available experimental data are analyzed by using a corrosion model in which the oxidation and scale removal are coupled. Based on the model, long-term behaviors of steels in liquid lead and lead-bismuth are predictable. This report provides information for the selection of structural materials for typical nuclear reactor coolant systems when selecting liquid lead or lead bismuth as heat transfer media.

Relationship between soil lead and airborne lead concentrations at Springfield, Missouri, USA.

Science.gov (United States)

Sheets, R W; Kyger, J R; Biagioni, R N; Probst, S; Boyer, R; Barke, K

2001-04-23

This study tests whether lead deposited to soil from automobiles during past years in a medium-sized US city (population 150,000) may present a current health risk. It examines the relationship between current soil lead concentrations at nine locations within the city of Springfield, Missouri, and airborne lead levels measured at the same locations during years (1975-1981) when lead emissions from automobiles were much greater than at present. A strong, significant correlation is found between soil and airborne lead levels at eight of the sites (r = 0.91, P lead vs. 1979 airborne lead), in low-traffic areas as well as in areas adjacent to heavy traffic flow. Residual lead concentrations in these soils are relatively low, even for the high-traffic sites, as expected for a medium sized city.

Uranium-lead systematics

International Nuclear Information System (INIS)

Wickman, F.E.

1983-01-01

The method of Levchenkov and Shukolyukov for calculating age and time disturbance of minerals without correction for original lead is generalized to include the cases when (1) original lead and radiogenic lead leach differently, and (2) the crystals studied consist of a core and a mantle. It is also shown that a straight line obtained from the solution of the equations is the locus of the isotopic composition of original lead. (Auth.)

Lead dust in Broken Hill homes: effect of remediation on indoor lead levels.

Science.gov (United States)

Boreland, F; Lyle, D M

2006-02-01

This study was undertaken to determine whether home remediation effectively reduced indoor lead levels in Broken Hill, a long-established silver-lead-zinc mining town in outback Australia. A before-after study of the effect of home remediation on indoor lead levels was embedded into a randomized controlled trial of the effectiveness of remediation for reducing elevated blood lead levels in young children. Moist towelettes were used to measure lead loading (microg/m2) on internal windowsills and internal and entry floors of 98 homes; samples were collected before, immediately after, and 2, 4, 6, 8, and 10 months after remediation. Data were log(10) transformed for the analysis. Remediation reduced average indoor lead levels by approximately 50%, and lead levels remained low for the duration of the follow-up period (10 months). The greatest gains were made in homes with the highest initial lead levels; homes with low preremediation lead levels showed little or no benefit. Before remediation, homes located in areas with high soil lead levels or with "poor" dust proofing had higher lead levels than those in areas with lower soil lead levels or with "medium" or "good" dust proofing; these relative differences remained after remediation. There was no evidence that lead loading was reduced by an increased opportunity to become aware of lead issues. We conclude that remediation is an effective strategy for reducing the lead exposure of children living in homes with high indoor lead levels.

High human exposure to lead through consumption of birds hunted with lead shot

International Nuclear Information System (INIS)

Johansen, P.; Asmund, G.; Riget, F.

2004-01-01

Lead shot contaminates the edible parts of birds so that tolerable human lead intake is exceeded. - We assess lead contamination of Greenland seabirds killed with lead shot having studied thick-billed murre and common eider, the two most important species in the diet. The lead concentration is very high in meat of eiders killed with lead shot (mean 6.1 μg/g-wet wt, 95% CL 2.1-12). This level is about 44 times higher than in drowned eiders and eight times higher than in shot murres. Analyzing whole breasts instead of sub-samples reveals about seven times higher lead levels in birds' meat. We conclude that in some cases the lead intake by Greenland bird eaters will largely exceed the FAO/WHO tolerable lead intake guideline and that lead shot is a more important source of lead in the diet than previously estimated

Lead in the environment

Science.gov (United States)

Pattee, Oliver H.; Pain, Deborah J.; Hoffman, David J.; Rattner, Barnett A.; Burton, G. Allen; Cairns, John

2003-01-01

Anthropogenic uses of lead have probably altered its availability and environmental distribution more than any other toxic element. Consequently, lead concentrations in many living organisms may be approaching thresholds of toxicity for the adverse effects of lead. Such thresholds are difficult to define, as they vary with the chemical and physical form of lead, exposure regime, other elements present and also vary both within and between species. The technological capability to accurately quantify low lead concentrations has increased over the last decade, and physiological and behavioral effects have been measured in wildlife with tissue lead concentrations below those previously considered safe for humans.s.236 Consequently. lead criteria for the protection of wildlife and human health are frequently under review, and 'thresholds' of lead toxicity are being reconsidered. Proposed lead criteria for the protection of natural resources have been reviewed by Eisler. Uptake of lead by plants is limited by its generally low availability in soils and sediments, and toxicity may be limited by storage mechanisms and its apparently limited translocation within most plants. Lead does not generally accumulate within the foliar parts of plants, which limits its transfer to higher trophic levels. Although lead may concentrate in plant and animal tissues, no evidence of biomagnification exists. Acid deposition onto surface waters and soils with low buffering capacity may influence the availability of lead for uptake by plants and animals, and this may merit investigation at susceptible sites. The biological significance of chronic low-level lead exposure to wildlife is sometimes difficult to quantify. Animals living in urban environments or near point sources of lead emission are inevitably subject to greater exposure to lead and enhanced risk of lead poisoning. Increasingly strict controls on lead emissions in many countries have reduced exposure to lead from some sources

Anemia risk in relation to lead exposure in lead-related manufacturing

Directory of Open Access Journals (Sweden)

Nan-Hung Hsieh

2017-05-01

Full Text Available Abstract Background Lead-exposed workers may suffer adverse health effects under the currently regulated blood lead (BPb levels. However, a probabilistic assessment about lead exposure-associated anemia risk is lacking. The goal of this study was to examine the association between lead exposure and anemia risk among factory workers in Taiwan. Methods We first collated BPb and indicators of hematopoietic function data via health examination records that included 533 male and 218 female lead-exposed workers between 2012 and 2014. We used benchmark dose (BMD modeling to estimate the critical effect doses for detection of abnormal indicators. A risk-based probabilistic model was used to characterize the potential hazard of lead poisoning for job-specific workers by hazard index (HI. We applied Bayesian decision analysis to determine whether BMD could be implicated as a suitable BPb standard. Results Our results indicated that HI for total lead-exposed workers was 0.78 (95% confidence interval: 0.50–1.26 with risk occurrence probability of 11.1%. The abnormal risk of anemia indicators for male and female workers could be reduced, respectively, by 67–77% and 86–95% by adopting the suggested BPb standards of 25 and 15 μg/dL. Conclusions We conclude that cumulative exposure to lead in the workplace was significantly associated with anemia risk. This study suggests that current BPb standard needs to be better understood for the application of lead-exposed population protection in different scenarios to provide a novel standard for health management. Low-level lead exposure risk is an occupational and public health problem that should be paid more attention.

Lead exposure from lead pellets: age-related accumulation in mute swans

Energy Technology Data Exchange (ETDEWEB)

Eskildsen, J.; Grandjean, P.

1984-05-01

In a cross-sectional study of adult swans and their successfully fledged young in Ringkobing Fjord, West Jutland, Denmark, 128 venous blood samples were taken during the moulting period and analyzed for lead. While the juveniles generally showed blood lead levels below 15 micrograms/100 ml (median, 11 micrograms/100 ml), the values were significantly higher in adults (median, 25 micrograms/100 ml). Adult females showed slightly higher levels than did adult males. None of the birds examined showed signs of acute lead toxicity, and increased blood levels in adults may reflect increased lead body burdens from previous ingestion of lead shot as gizzard stones.

Lead-free piezoceramics.

Science.gov (United States)

Saito, Yasuyoshi; Takao, Hisaaki; Tani, Toshihiko; Nonoyama, Tatsuhiko; Takatori, Kazumasa; Homma, Takahiko; Nagaya, Toshiatsu; Nakamura, Masaya

2004-11-04

Lead has recently been expelled from many commercial applications and materials (for example, from solder, glass and pottery glaze) owing to concerns regarding its toxicity. Lead zirconium titanate (PZT) ceramics are high-performance piezoelectric materials, which are widely used in sensors, actuators and other electronic devices; they contain more than 60 weight per cent lead. Although there has been a concerted effort to develop lead-free piezoelectric ceramics, no effective alternative to PZT has yet been found. Here we report a lead-free piezoelectric ceramic with an electric-field-induced strain comparable to typical actuator-grade PZT. We achieved this through the combination of the discovery of a morphotropic phase boundary in an alkaline niobate-based perovskite solid solution, and the development of a processing route leading to highly textured polycrystals. The ceramic exhibits a piezoelectric constant d33 (the induced charge per unit force applied in the same direction) of above 300 picocoulombs per newton (pC N(-1)), and texturing the material leads to a peak d33 of 416 pC N(-1). The textured material also exhibits temperature-independent field-induced strain characteristics.

Specificities of reactor coolant pumps units with lead and lead-bismuth coolant

International Nuclear Information System (INIS)

Beznosov, A.V.; Anotonenkov, M.A.; Bokov, P.A.; Baranova, V.S.; Kustov, M.S.

2009-01-01

The analysis results of impact of lead and lead-bismuth coolants specific properties on the coolants flow features in flow channels of the main and auxiliary circulating pumps are presented. Impossibility of cavitation initiation in flow channels of vane pumps pumping lead and lead-bismuth coolants was demonstrated. The experimental research results of discontinuity of heavy liquid metal coolant column were presented and conditions of gas cavitation initiation in coolant flow were discussed. Invalidity of traditional calculation methods of water and sodium coolants circulation pumps calculations for lead and lead-bismuth coolants circulation pumps was substantiated [ru

Photocatalyzed removal of lead ion from lead-chelator solution

Energy Technology Data Exchange (ETDEWEB)

Cho, Young Hyun; Na, Jung Won; Sung, Ki Woung [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

1994-07-01

The present study was undertaken to examine the influence of such chelating agents on the ease and speed of photocatalyzed metal removal and deposition. With excess EDTA, the free EDTA competes with Pb for oxidation, and at a ten fold excess, no lead oxidation (hence removal) occurs. With insufficient EDTA, the corresponding initial concentration of Pb-EDTA is decreased; after its destruction, the remaining Pb{sup 2+} is removed more slowly, at rates found with lead nitrate solution. The net result is that the maximum rate of lead deposition occurs at the stoichiometric ratio of 1:1 EDTA : Pb{sup 2+}.

Vector boson and Charmonium production in proton-lead and lead-lead collisions with ATLAS at the LHC

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00241320; The ATLAS collaboration

2016-01-01

Electroweak bosons do not interact strongly with the dense and hot medium formed in nuclear collisions, and thus should be sensitive to the nuclear modification of parton distribution functions (nPDFs). The in-medium modification of heavy charmonium states plays an important role in studying the hot and dense medium. The ATLAS detector, optimized to search for new physics in proton-proton collisions, is well equipped to measure Z and W bosons as well as quarkonium in the high occupancy environment produced in heavy ion collisions. Results from the ATLAS experiment on W and Z boson yields as a function of centrality, transverse momentum and rapidity, in lead-lead and proton-lead collisions are presented. Quarkonium results from proton-lead collisions are also presented.

Report of a consultants meeting on backfittings and safety enhancement measures in NPPs with WWER 440/213 reactors. Extrabudgetary programme on the safety of WWER NPPS

International Nuclear Information System (INIS)

1994-01-01

The purpose of this Consultants' Meeting held by the IAEA in Vienna from 11-15 April 1994 within the framework of the Extrabudgetary Programme on WWER Safety was to review and analyze safety issues revealed during operation and through analyses of NPPs with WWER 440/213 reactors. The initial list of safety issues based on the available reports from various studies had been prepared by the IAEA secretariat before the meeting, together with indications of safety enhancement measures proposed in various NPP units. During the meeting, the underlying safety concerns and actual technical status of the plants were discussed and the ranking of the safety issues was considered. 58 refs, 1 tab

Lead-elevated activity of xanthine oxidase in lead-exposed workers

Directory of Open Access Journals (Sweden)

Sławomir Kasperczyk

2013-04-01

Full Text Available Background: The aim of the present study was to explore the connection between lead toxicity and the activity of xanthine oxidase (XO. In addition, we indicated the uric acid (UA and creatinine levels and concentration of erythrocyte malondialdehyde (MDA to estimate oxidative stress intensity. Materials and Methods: The examined group consisted of 125 healthy male employees of zinc and lead works. The examined group was divided into tertiles according to blood lead levels. In the collected blood samples, concentrations of lead-exposure indices, UA, creatinine, and MDA as well as activity of XO were measured concomitantly. The control group consisted of 32 healthy male administrative workers who were exposed to lead only environmentally. Results: XO activity and MDA level were significantly elevated in all tertiles compared to the control group. Creatinine level was significantly elevated in the medium and high tertiles. However, the level of UA was significantly elevated in the high tertile, while in the low and medium tertile only a tendency toward higher values was observed. Conclusions: Occupational exposure to lead induces activity of XO. This induction may contribute to the observed simultaneously increased oxidative stress, measured as MDA level, and the increased level of UA. Med Pr 2013;64(2:175–180

Role of Airborne Lead in Increased Body Burden of Lead in Hartford Children*

Science.gov (United States)

Lepow, Martha L.; Bruckman, Leonard; Rubino, Robert A.; Markowitz, Steven; Gillette, Marybeth; Kapish, Janet

1974-01-01

The ingestion of airborne lead fallout is the mechanism responsible for increased lead body burdens found in 10 urban Connecticut children. The mean indoor lead levels found in housedust was 11,000 μg/g; highest concentrations occurred on windowsills and in floor dust. The mean lead content of Hartford street dirt was 1,200 μg/g; levels were highest near the street and next to the buildings. The mean lead concentration of hand samples taken from the subject children was 2,400 μg/g; the mean weight of hand samples was 11 mg. The concentration of lead in dirt and househould dust was high enough to theoretically result in excessive lead accumulation in young children who are putting their dusty, dirty hands in their mouths during play. While we believe that lead emitted from automobiles contributes significantly to air, dirt and dust lead levels the environmental impact of reducing or eliminating lead from gasoline is not yet completely understood. PMID:4133903

Lead Poisoning Prevention Tips

Science.gov (United States)

... or removed safely. How are children exposed to lead? Lead-based paint and lead contaminated dust are ... What can be done to prevent exposure to lead? It is important to determine the construction year ...

Electronic Properties and Photovoltaic Performances of a Series of Oligothiophene Copolymers Incorporating Both Thieno[3,2-b]thiophene and 2,1,3-Benzothiadiazole Moieties.

Science.gov (United States)

Biniek, Laure; Chochos, Christos L; Hadziioannou, Georges; Leclerc, Nicolas; Lévêque, Patrick; Heiser, Thomas

2010-04-06

A series of donor-acceptor alternated conjugated copolymers, composed of thiophene, bithiophene, thieno[3,2-b]thiophene, and 2,1,3-benzothiadiazole units and differing from each other by the nature and the number of 3-alkylthiophene in the backbone, have been synthesized by Stille cross-coupling polymerization. The material's optical and electrochemical properties, in solution and in thin films, have been investigated using UV-Visible absorption and cyclic voltammetry. Bulk heterojunction solar cells using blends of the newly synthesized copolymers, as electron donor, and C60-PCBM or C70-PCBM, as electron transporting material, have been elaborated. A maximum power conversion efficiency of 1.8% is achieved with a 1:4 PPBzT(2) -C12:C70-PCBM weight ratio. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The effects of thiamin on lead metabolism: organ distribution of lead 203.

OpenAIRE

Kim, J S; Hamilton, D L; Blakley, B R; Rousseaux, C G

1992-01-01

The effect of thiamin on the organ distribution of lead was evaluated in CD-1 mice exposed intragastrically or intraperitoneally to a single dose of lead acetate (100 micrograms) containing 100 microCi lead 203. They were treated with either thiamin (25 or 50 mg/kg body weight), calcium ethylenediaminetetraacetic acid (CaEDTA) (50 mg/kg body weight), or combinations of thiamin and CaEDTA. The whole body retention and the organ distribution of lead 203 varied depending upon the route of lead a...

Method of handling of scrap lead from lead-acid batteries

Energy Technology Data Exchange (ETDEWEB)

Sytschev, A P; Kim, G V; Larin, V F; Sidorova, G D; Vicharev, I G; Kuur, V P; Achmetov, R S; Moiseev, G L; Maslov, V I; Kabatschek, V G

1979-12-13

Scrap lead and the casings of accumulators are mined and molten together in oxidixing atmosphere at a temperature of 1300 to 1500/sup 0/C. The lead oxide contained in the melt is then reduced to blue lead. Due to the combustion of the accumulator casings consisting of organic substances the fuel consumption in the melting process is reduced in accordance. The oxidizing atmosphere in the melting process is produced by use of air or oxygen.

Lead isotope ratios in artists' lead white: a progress report

Energy Technology Data Exchange (ETDEWEB)

Keisch, B; Callahan, R C [Carnegie-Mellon Univ., Pittsburgh, Pa. (USA)

1976-07-01

The lead isotope ratios in over four hundred samples of lead white have been determined. The samples represent various geographical sources and dates from the thirteenth century to the present. A new method for organizing this large volume of data is described which helps with the visualization of temporal and geographic patterns. A number of interesting relationships between lead isotope ratio and date or source are shown to exist. Some examples of successful applications of this methodology are described.

Activity of lead deposited in the tissues in conditions of occupational lead exposure

Energy Technology Data Exchange (ETDEWEB)

1974-01-01

The author measured urinary excretion of delta-aminolevulinic acid (ALA), coproporphyrins and lead, before and after administration of chelating agents (CaEDTA and D-penicillamine) to subjects presenting clinical symptoms of lead poisoning and workers occupationally exposed to lead. He found a great increase in lead following its mobilization in subjects with lead poisoning who had previously shown a high level of haemoglobin precursors and a low urinary lead level. In these subjects ALA excretion was proportional to the duration of exposure. A correlation was found between urinary ALA and coproporphyrins, on the one hand, and lead excretion after provocation, on the other. This suggests that the lead deposited in the tissues, as well as that in circulation, retains all its activity.

Health care of people at work. Workers exposed to lead. I. Inorganic lead

Energy Technology Data Exchange (ETDEWEB)

Waldron, H.A.

1978-01-01

The risks associated with exposure to inorganic lead and the means by which these risks can be minimized are outlined. Lead is used to make a variety of metal products, the grids and oxides in storage batteries, pigments, chemicals, and also for lead plating. In the United States about 70% of the total lead consumption is related to transportation. Uptake of inorganic lead is by ingestion and inhalation. About 90% of the total body burden of lead is contained within the skeletal tissues. Lead is excreted in the kidney, in sweat, and in milk. Toxic effects are directed against the blood, the nervous system, and the kidney. Symptoms of lead poisoning are abdominal pain, constipation, vomiting, asthenia, paresthesia, psychological symptoms, and diarrhea. Physical and biological monitoring can serve to protect workers. Diagnosis of lead poisoning is not easy. Treatment involves removal from exposure and/or treatment with a chelating agent.

Leading Democratically

Science.gov (United States)

Brookfield, Stephen

2010-01-01

Democracy is the most venerated of American ideas, the one for which wars are fought and people die. So most people would probably agree that leaders should be able to lead well in a democratic society. Yet, genuinely democratic leadership is a relative rarity. Leading democratically means viewing leadership as a function or process, rather than…

Who Leads China's Leading Universities?

Science.gov (United States)

Huang, Futao

2017-01-01

This study attempts to identify the major characteristics of two different groups of institutional leaders in China's leading universities. The study begins with a review of relevant literature and theory. Then, there is a brief introduction to the selection of party secretaries, deputy secretaries, presidents and vice presidents in leading…

Remediation of lead contaminated soil

International Nuclear Information System (INIS)

Urban, W.; Krishnamurthy, S.

1992-01-01

Lead contaminated soil in urban area is of major concern because of the potential health risk to children. Many studies have established a direct correlation between lead in soil and elevated blood lead levels in children. In Minneapolis, Minnesota, Mielke et al. (1983) reported that 50% of the Hmong children with lead poisioning were in areas where soil lead levels were between 500 and 1000 micrograms per gram (ug/g), and 40% of the children suffering from lead poisioning lived in areas where soil lead levels exceeded 1000 ug/g. In urban areas, lead pollution in soil has come from many different sources. The sources include lead paint, lead batteries and automobile exhaust. Olson and Skogerbee (1975) found the following lead compounds in soils where the primary source of pollution was from automobiles: lead sulfate, lead oxide, lead dioxide, lead sulfide, and metallic lead. The primary form of lead found was lead sulfate. Lead sulfate, lead tetraoxide, white lead, and other forms of lead have been used in the manufacture of paints for houses. At present, two remediation techniques, solidification and Bureau of Mines fluosilicic acid leaching, are available for lead-contaminated sites. The objective of the present investigation at the Risk Reduction Engineering Laboratory (RREL), Edison, was to try to solubilize the lead species by appropriate reagents and then recover the contaminants by precipitation as lead sulfate, using environmentally acceptable methods. The apparatus used for mixing was a LabMaster mixer, with variable speed and high-shear impeller. Previous work had used nitric acid for dissolving metallic lead. Owing to the environmental concerns, it was decided to use acetic acid in the presence of oxygen. The theoretical justification for this approach is the favorable redox potential for the reaction between metallic lead, acetic acid, and gaseous oxygen

Lead theft--a study of the "uniqueness" of lead from church roofs.

Science.gov (United States)

Bond, John W; Hainsworth, Sarah V; Lau, Tien L

2013-07-01

In the United Kingdom, theft of lead is common, particularly from churches and other public buildings with lead roofs. To assess the potential to distinguish lead from different sources, 41 samples of lead from 24 church roofs in Northamptonshire, U.K, have been analyzed for relative abundance of trace elements and isotopes of lead using X-ray fluorescence (XRF) and inductively coupled plasma mass spectrometry, respectively. XRF revealed the overall presence of 12 trace elements with the four most abundant, calcium, phosphorus, silicon, and sulfur, showing a large weight percentage standard error of the mean of all samples suggesting variation in the weight percentage of these elements between different church roofs. Multiple samples from the same roofs, but different lead sheets, showed much lower weight percentage standard errors of the mean suggesting similar trace element concentrations. Lead isotope ratios were similar for all samples. Factors likely to affect the occurrence of these trace elements are discussed. © 2013 American Academy of Forensic Sciences.

Lead isotope ratios in artists' lead white: a progress report

International Nuclear Information System (INIS)

Keisch, B.; Callahan, R.C.

1976-01-01

The lead isotope ratios in over four hundred samples of lead white have been determined. The samples represent various geographical sources and dates from the thirteenth century to the present. A new method for organizing this large volume of data is described which helps with the visualization of temporal and geographic patterns. A number of interesting relationships between lead isotope ratio and date or source are shown to exist. Some examples of successful applications of this methodology are described. (author)

Quantification of atmospheric lead emissions from 70 years of leaded petrol consumption in Australia

Science.gov (United States)

Kristensen, Louise Jane

2015-06-01

Lead is a persistent pollutant and the subject of many environmental studies, yet, in Australia, the extent of atmospheric lead emissions from the use of leaded petrol is unquantified. This paper details the first comprehensive account of leaded petrol sales and its lead concentrations over the 70 years of use in Australia. The resulting atmospheric lead emissions are calculated to provide the most complete understanding of the volume of lead released to the Australian continent from the consumption of leaded petrol. Atmospheric emissions of lead to the entire Australian continent from leaded petrol are calculated to total 240,510 tonnes over seven decades of use, peaking at 7869 tonnes in 1974. Total emissions for individual states and territories range from 1745 to 67,893 tonnes, with New South Wales responsible for the largest emissions. The effect of regulations on allowable concentrations of tetraethyl-lead additives are observed in the reduction of lead emissions in New South Wales and Victoria. The consequences to human health and the environment of leaded petrol consumption in Australia's populous cities are examined against historical air quality data and blood lead levels.

Large-capacity current leads

International Nuclear Information System (INIS)

Ballarino, A.

2008-01-01

Feeding superconducting magnets with reliable low-loss devices is a key issue for any cryo-electrical system. Conventional or HTS current leads can be used, and cooling methods, materials, and geometries can be chosen to optimize the thermo-electrical performance of the system. The LHC magnets are powered via more than 3000 current leads transporting altogether about 3 MA of current. With thousands of leads, the LHC lead project represents today the largest project of its kind ever undertaken. Following a review of the LHC lead project, an overview of the choices that can be made for the optimization of large capacity current leads is presented. Examples are given of other leads for large scale magnet systems for which the use of HTS is being envisaged

Performance of Lead-Free versus Lead-Based Hunting Ammunition in Ballistic Soap

Science.gov (United States)

Gremse, Felix; Krone, Oliver; Thamm, Mirko; Kiessling, Fabian; Tolba, René Hany; Rieger, Siegfried; Gremse, Carl

2014-01-01

Background Lead-free hunting bullets are an alternative to lead-containing bullets which cause health risks for humans and endangered scavenging raptors through lead ingestion. However, doubts concerning the effectiveness of lead-free hunting bullets hinder the wide-spread acceptance in the hunting and wildlife management community. Methods We performed terminal ballistic experiments under standardized conditions with ballistic soap as surrogate for game animal tissue to characterize dimensionally stable, partially fragmenting, and deforming lead-free bullets and one commonly used lead-containing bullet. The permanent cavities created in soap blocks are used as a measure for the potential wound damage. The soap blocks were imaged using computed tomography to assess the volume and shape of the cavity and the number of fragments. Shots were performed at different impact speeds, covering a realistic shooting range. Using 3D image segmentation, cavity volume, metal fragment count, deflection angle, and depth of maximum damage were determined. Shots were repeated to investigate the reproducibility of ballistic soap experiments. Results All bullets showed an increasing cavity volume with increasing deposited energy. The dimensionally stable and fragmenting lead-free bullets achieved a constant conversion ratio while the deforming copper and lead-containing bullets showed a ratio, which increases linearly with the total deposited energy. The lead-containing bullet created hundreds of fragments and significantly more fragments than the lead-free bullets. The deflection angle was significantly higher for the dimensionally stable bullet due to its tumbling behavior and was similarly low for the other bullets. The deforming bullets achieved higher reproducibility than the fragmenting and dimensionally stable bullets. Conclusion The deforming lead-free bullet closely resembled the deforming lead-containing bullet in terms of energy conversion, deflection angle, cavity shape

Performance of lead-free versus lead-based hunting ammunition in ballistic soap.

Directory of Open Access Journals (Sweden)

Felix Gremse

Full Text Available BACKGROUND: Lead-free hunting bullets are an alternative to lead-containing bullets which cause health risks for humans and endangered scavenging raptors through lead ingestion. However, doubts concerning the effectiveness of lead-free hunting bullets hinder the wide-spread acceptance in the hunting and wildlife management community. METHODS: We performed terminal ballistic experiments under standardized conditions with ballistic soap as surrogate for game animal tissue to characterize dimensionally stable, partially fragmenting, and deforming lead-free bullets and one commonly used lead-containing bullet. The permanent cavities created in soap blocks are used as a measure for the potential wound damage. The soap blocks were imaged using computed tomography to assess the volume and shape of the cavity and the number of fragments. Shots were performed at different impact speeds, covering a realistic shooting range. Using 3D image segmentation, cavity volume, metal fragment count, deflection angle, and depth of maximum damage were determined. Shots were repeated to investigate the reproducibility of ballistic soap experiments. RESULTS: All bullets showed an increasing cavity volume with increasing deposited energy. The dimensionally stable and fragmenting lead-free bullets achieved a constant conversion ratio while the deforming copper and lead-containing bullets showed a ratio, which increases linearly with the total deposited energy. The lead-containing bullet created hundreds of fragments and significantly more fragments than the lead-free bullets. The deflection angle was significantly higher for the dimensionally stable bullet due to its tumbling behavior and was similarly low for the other bullets. The deforming bullets achieved higher reproducibility than the fragmenting and dimensionally stable bullets. CONCLUSION: The deforming lead-free bullet closely resembled the deforming lead-containing bullet in terms of energy conversion

Penetration of a magnetic field into superconducting lead and lead-indium alloys

International Nuclear Information System (INIS)

Egloff, C.; Raychaudhuri, A.K.; Rinderer, L.

1983-01-01

The temperature dependence of the magnetic field penetration depth of superconducting lead and lead-indium alloys has been studied over the temperature range between about 2 K and T/sub c/. Data are analyzed in terms of the microscopic theory. The difficulties of a unique analysis of the penetration data are pointed out and a strategy for the analysis is discussed. The penetration depth at T = 0K for pure lead is determined as 522 A. This value, though higher than the previously accepted value for lead, is nevertheless consistent with the strong coupling character of lead

Lead inclusions in aluminium

International Nuclear Information System (INIS)

Johnson, E.; Johansen, A.; Sarholt-Kristensen, L.; Andersen, H.H.; Grabaek, L.; Bohr, J.

1990-01-01

Ion implantation at room temperature of lead into aluminum leads to spontaneous phase separation and formation of lead precipitates growing topotactically with the matrix. Unlike the highly pressurized (∼ 1-5 GPa) solid inclusions formed after noble gas implantations, the pressure in the lead precipitates is found to be less than 0.12 GPa. Recently the authors have observed the result that the lead inclusions in aluminum exhibit both superheating and supercooling. In this paper they review and elaborate on these results. Small implantation-induced lead precipitates embedded in an aluminum matrix were studied by x-ray diffraction

EP toxicity testing of lead to resolve disposition of radioactively contaminated lead

International Nuclear Information System (INIS)

Larsen, M.M.; Boehmer, A.M.

1986-03-01

The Department of Energy (DOE), in its efforts to comply with the requirements of the Resource Conservation and Recovery Act (RCRA) of 1976, is concerned with hazardous waste which is also radioactively contaminated. There are no existing facilities to treat or dispose of these wastes. One such waste is lead, which is extensively used in the nuclear industry as shielding. This paper reports the results of leach testing of lead (both solid lead samples and lead shot) to resolve questions as to whether or not radioactively contaminated waste lead must be treated as a hazardous waste. The results of these tests showed that: some samples passed the leach test. Results of development efforts performed to date to recycle lead and those planned for the future are included in this report

The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

Directory of Open Access Journals (Sweden)

Tracy Russell P

2011-03-01

Full Text Available Abstract Background Genetic risk factors might improve prediction of coronary events. Several variants at chromosome 9p21.3 have been widely reported to be associated with coronary heart disease (CHD in prospective and case-control studies. A variant of KIF6 (719Arg has also been reported to be associated with increased risk of CHD in large prospective studies, but not in case-control studies. We asked whether the addition of genetic information (the 9p21.3 or KIF6 variants or a well-established non-genetic risk factor (C-reactive protein [CRP] can improve risk prediction by the Framingham Risk Score (FRS in the Cardiovascular Health Study (CHS--a prospective observational study of risk factors for cardiovascular disease among > 5,000 participants aged 65 or older. Methods Improvement of risk prediction was assessed by change in the area under the receiver-operator characteristic curve (AUC and by net reclassification improvement (NRI. Results Among white participants the FRS was improved by addition of KIF6 719Arg carrier status among men as assessed by the AUC (from 0.581 to 0.596, P = 0.03 but not by NRI (NRI = 0.027, P = 0.32. Adding both CRP and 719Arg carrier status to the FRS improved risk prediction by the AUC (0.608, P = 0.02 and NRI (0.093, P = 0.008 in men, but not women (P ≥ 0.24. Conclusions While none of these risk markers individually or in combination improved risk prediction among women, a combination of KIF6 719Arg carrier status and CRP levels modestly improved risk prediction among white men; although this improvement is not significant after multiple-testing correction. These observations should be investigated in other prospective studies.

Determination of the neutron detection efficiency of an NE213 scintillator for E{sub n}=2.5 to 16 MeV using the {sup 2}H(d,n){sup 3}He reaction

Energy Technology Data Exchange (ETDEWEB)

Al-Ohali, M.A.; Aksoy, A.; Coban, A. [King Fahd Univ. of Pet. and Miner., Dhahran (Saudi Arabia). Energy Res. Lab.; Hanly, J.M.; Felsher, P.D.; Howell, C.R.; Tornow, W.; Salinas, F.; Walter, R.L. [Duke University and Triangle Universities Nuclear Laboratories, Durham, NC 27708 (United States)

1997-09-11

The absolute efficiency of an NE213 liquid scintillator of 12.7 cm diameter and 5.08 cm thickness was measured in the neutron energy range 2.5-16 MeV using the {sup 2}H(d,n){sup 3}He reaction as a source of monoenergetic neutrons. The efficiencies were measured at the time-of-flight facility of Triangle Universities Nuclear Laboratory TUNL. The experimental data are compared to calculations from the Monte Carlo code NEFF of Physikalisch-Technische Bundesanstalt, Braunschweig, Germany PTB. (orig.). 7 refs.

Elution of lead from lead zirconate titanate ceramics to acid rain

Science.gov (United States)

Tsurumi, Takaaki; Takezawa, Shuhei; Hoshina, Takuya; Takeda, Hiroaki

2017-10-01

The amount of lead that eluted from lead zirconate titanate (PZT) ceramics to artificial acid rain was evaluated. Four kinds of PZT ceramics, namely, pure PZT at MPB composition, CuO-added PZT, PZT with 10 mol % substitution of Ba for Pb, and CuO-added PZT with 10 mol % substitution of Ba for Pb, were used as samples of the elution test. These PZT ceramics of 8 mm2 and 1.1-1.2 mm thickness were suspended in 300 ml of H2SO4 solution of pH 4.0. The concentration of lead eluted from PZT was in the range from 0.2 to 0.8 ppm. It was found that both liquid phase formation by the addition of CuO and the substitution of Ba for Pb were effective to reduce the amount of lead that eluted. By fitting the leaching out curve with a classical equation, a master curve assuming no sampling effect was obtained. The lead concentration evaluated from the amount of lead that eluted from a commercial PZT plate to H2SO4 solution of pH 5.3 was almost the same as the limit in city water. It is concluded that PZT is not harmful to health and the environment and the amount of lead that eluted from PZT can be controlled by modifying PZT composition.

Long range correlations, leading particle spectrum and correlations with leading particles

International Nuclear Information System (INIS)

Ilgenfritz, E.M.

1976-05-01

The unitary cluster emission model by de Groot and Ruijgrok is discussed as an approach to understand the leading particle behaviour. Consequences of the model concerning co--rrelations between leading particles and produced particles in the central region are considered. No satisfactory agreement was found. Production of leading clusters is argued for being an essential feature of these correlations. (author)

Comparative toxicity of tetra ethyl lead and lead oxide to earthworms, Eisenia fetida (Savigny)

International Nuclear Information System (INIS)

Venkateswara Rao, J.; Kavitha, P.; Padmanabha Rao, A.

2003-01-01

Leaded gasoline contains tetra ethyl lead (TEL) as an antiknocking agent, which produces major amounts of lead oxide in automobile exhaust along with traces of TEL. To minimize the lead contamination, methyl tertiary butyl ether (MTBE) is used as a substitute for producing unleaded gasoline. It has become increasingly apparent that young children are highly susceptible to the harmful effects of lead. Hence, a study was carried out to monitor lead toxicity in soil, using adult earthworms (Eisenia fetida, Savigny). Leaded gasoline (TEL) and lead oxide are 383- and 211-fold more toxic than unleaded gasoline (MTBE) in 7 days of exposure and 627- and 290-fold more toxic in 14 days, respectively. Results indicate that the presence of TEL in leaded gasoline and lead oxide has a significant effect on behavior, morphology, and histopathology of earthworms. Absorption of TEL into the tissues is comparatively less than that of lead oxide but toxic effects were severe. Rupture of the cuticle, extrusion of coelomic fluid and inflexible metameric segmentation were observed, causing desensitization of the posterior region leading to fragmentation in earthworms

Lead-resistant Providencia alcalifaciens strain 2EA bioprecipitates Pb+2 as lead phosphate.

Science.gov (United States)

Naik, M M; Khanolkar, D; Dubey, S K

2013-02-01

A lead-resistant bacteria isolated from soil contaminated with car battery waste were identified as Providencia alcalifaciens based on biochemical characteristics, FAME profile and 16S rRNA sequencing and designated as strain 2EA. It resists lead nitrate up to 0·0014 mol l(-1) by precipitating soluble lead as insoluble light brown solid. Scanning electron microscopy coupled with energy-dispersive X-ray spectrometric analysis (SEM-EDX) and X-ray diffraction spectroscopy (XRD) revealed extracellular light brown precipitate as lead orthophosphate mineral, that is, Pb(9) (PO(4))(6) catalysed by phosphatase enzyme. This lead-resistant bacterial strain also demonstrated tolerance to high levels of cadmium and mercury along with multiple antibiotic resistance. Providencia alcalifaciens strain 2EA could be used for bioremediation of lead-contaminated environmental sites, as it can efficiently precipitate lead as lead phosphate. © 2012 The Society for Applied Microbiology.

Lead isotopes in soils near five historic American lead smelters and refineries

International Nuclear Information System (INIS)

Rabinowitz, Michael B.

2005-01-01

This survey of soil lead in the vicinity of old industrial sites examines how the stable isotope patterns vary among the sites according to the sources of the lead ore processed at each site. Lead smelters and refineries, which closed down decades ago, are the basis of this investigation. Samples were taken from near five old factory sites in Collinsville and Alton (Illinois), Ponderay (Idaho), East Chicago (Indiana) and Omaha (Nebraska). Historical records were searched for accounts of the sources of the lead. Lead concentrations were measured by atomic absorption flame spectrophotometry, and stable isotopic analysis was done by plasma ionization mass spectrometry. At every site visited, remnants of the old factories, in terms of soil lead pollution, could be found. In spite of potential complications of varying smelter feedstock sourced from mines of different geological age, it was possible to match the isotopic patterns in the soils with the documented sources of the ores. The Collinsville and Alton sites resembled Missouri lead. The Ponderay value was higher than major Bunker Hill, Idaho deposits, but closer to the minor, nearby Oreille County, Washington ores. Mostly Utah ore was used in East Chicago. The Omaha soil reflects lead from Mexico, Colorado and Montana

The void nucleation mechanism within lead phase during spallation of leaded brass

Science.gov (United States)

Yang, Yang; Wang, Can; Chen, Xingzhi; Chen, Kaiguo; Hu, Haibo; Fu, Yanan

2018-07-01

The incipient spall behaviours of Cu-34%Zn-3%Pb leaded brass samples with annealed and cryogenic-treated conditions were loaded using one-stage light gas gun experiments. The effect of Pb-phase on dynamic damage nucleation in leaded brass specimens was investigated by means of optical microscopy, scanning electron microscopy and x-ray computer tomography. It was found that the voids of incipient spall were mainly nucleated in the interior of the lead (no tensile stress would be produced within lead according to the impact theory) instead of nucleated at the phase interface as expected by quasi-static damage fracture theory. A nucleation model is proposed in the present work that is the asymmetry high compression zones in the centre of the lead-phase were formed by the rarefaction wave convergence effects of matrix/quasi-spherical lead interface, which caused adiabatic temperature rise that exceeded melting point of lead due to severe plastic deformation, finally led to local melting and void nucleation. In addition, the spall strength and damage rate increased with the increase in the Pb-phase number.

Lead toxicity on hematological parameters in workers with occupational exposure to lead

International Nuclear Information System (INIS)

Dursun, N.; Koese, K.

1998-01-01

The effects of lead on hematological parameters were studied in lead exposed male workers occupied for 17.84+-4.22 years in a metal powder producing factory in Kayseri, Turkey and control male workers in same city. Blood lead and plasma zinc levels were measured by Atomic Absorption Spectrophotometry (AAS) and hematological parameters by Culture Counter S. The lead exposure workers had higher lead levels (13.81+- 9.21 mug/dl) as compared to control subjects (2.37+-0.10 mug/dl). No difference was observed in the plasma zinc levels of both groups. As indices of lead exposure, red blood cell (RBC) counts, hemoglobin (Hb), and hematocrit (Hct) values significantly decreased. Mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular haemoglobin concentration (MCHC) significantly increased except MCV. There was also an increase in MCV, but it was not significant. (author)

Monetary benefits of preventing childhood lead poisoning with lead-safe window replacement

OpenAIRE

Nevin, Rick; Jacobs, David / E.; Berg, Michael; Cohen, Jonathan

2007-01-01

Previous estimates of childhood lead poisoning prevention benefits have quantified the present value of some health benefits, but not the costs of lead paint hazard control or the benefits associated with housing and energy markets. Because older housing with lead paint constitutes the main exposure source today in the U.S., we quantify health benefits, costs, market value benefits, energy savings, and net economic benefits of lead-safe window replacement (which includes paint stabilization ...

Pacemaker lead fracture without an increase in lead impedance caused by cardiac fibroma

Directory of Open Access Journals (Sweden)

Daisuke Sato

2013-12-01

Full Text Available We report the case of a 64-year-old man who had a permanent pacemaker with a unipolar silicone electrode positioned in the right ventricle in 1989 for sinus node dysfunction. On a routine checkup in June 2011, a 28-mm-diameter mass was discovered, which appeared to adhere to the tricuspid valve and the ventricular lead. The size of the mass did not change for the next 6 months, and the lead impedance was maintained at around 500–600 Ω. Because pacing failure was observed in January 2012, he underwent an urgent pacemaker check; however, the lead impedance was found not to have increased greatly (689 Ω. Nevertheless, the pacemaker lead was noted to be fractured at the tricuspid level. His echocardiogram showed new severe tricuspid regurgitation and a floating mass around the lead. We extracted the fractured lead, enucleated the tumor, replaced the tricuspid valve, and placed an epicardial lead. Macroscopic examination revealed that the tumor surrounded the fractured lead and covered the stump. Pathological examination revealed that the tumor was composed of fibrous connective tissue. We presumed that electric current continued to flow through the stump of the fractured unipolar lead to the generator, and this might have caused the limited increase in lead impedance.

Evaluation of an experiment modelling heat transfer from the melt pool for use in VVER 440/213 reactors

International Nuclear Information System (INIS)

Skop, J.

2003-12-01

The strategy of confining core melt within the reactor vessel is among promising strategies to mitigate severe accidents of VVER 440/213 reactors. This strategy consists in residual heat removal from the melt by external vessel cooling from the outside, using water from the flooded reactor downcomer. This approach can only be successful if the critical heat flux on the external vessel surface is not exceeded. This can be assessed based on the parameters of heat transfer from the core melt pool in the conditions of natural circulation within the pool. Those parameters are the subject of the report. A basic description of the terms and physical basis of the strategy of confining core melt inside the vessel is given in Chapter 2, which also briefly explains similarity theory, based on which the results obtained on experimental facilities, using simulation materials, can be related to the actual situation inside a real reactor. Chapter 3 presents an overview of experimental work addressing the characteristics of heat transfer from the core melt pool in natural circulation conditions and a description of the experimental facilities. An overview of the results emerging from the experiments and their evaluation with respect to their applicability to reactors in Czech nuclear power plants are given in Chapter 4

Highly reversible lead-carbon battery anode with lead grafting on the carbon surface

KAUST Repository

Yin, Jian; Lin, Nan; Zhang, Wenli; Lin, Zheqi; Zhang, Ziqing; Wang, Yue; Shi, Jun; Bao, Jinpeng; Lin, Haibo

2018-01-01

A novel C/Pb composite has been successfully prepared by electroless plating to reduce the hydrogen evolution and achieve the high reversibility of the anode of lead-carbon battery (LCB). The deposited lead on the surface of C/Pb composite was found to be uniform and adherent to carbon surface. Because lead has been stuck on the surface of C/Pb composite, the embedded structure suppresses the hydrogen evolution of lead-carbon anode and strengthens the connection between carbon additive and sponge lead. Compared with the blank anode, the lead-carbon anode with C/Pb composite displays excellent charge–discharge reversibility, which is attributed to the good connection between carbon additives and lead that has been stuck on the surface of C/Pb composite during the preparation process. The addition of C/Pb composite maintains a solid anode structure with high specific surface area and power volume, and thereby, it plays a significant role in the highly reversible lead-carbon anode.

Highly reversible lead-carbon battery anode with lead grafting on the carbon surface

KAUST Repository

Yin, Jian

2018-03-27

A novel C/Pb composite has been successfully prepared by electroless plating to reduce the hydrogen evolution and achieve the high reversibility of the anode of lead-carbon battery (LCB). The deposited lead on the surface of C/Pb composite was found to be uniform and adherent to carbon surface. Because lead has been stuck on the surface of C/Pb composite, the embedded structure suppresses the hydrogen evolution of lead-carbon anode and strengthens the connection between carbon additive and sponge lead. Compared with the blank anode, the lead-carbon anode with C/Pb composite displays excellent charge–discharge reversibility, which is attributed to the good connection between carbon additives and lead that has been stuck on the surface of C/Pb composite during the preparation process. The addition of C/Pb composite maintains a solid anode structure with high specific surface area and power volume, and thereby, it plays a significant role in the highly reversible lead-carbon anode.

Impact of lead tolerant plant growth promoting rhizobacteria on growth, physiology, antioxidant activities, yield and lead content in sunflower in lead contaminated soil.

Science.gov (United States)

Saleem, Muhammad; Asghar, Hafiz Naeem; Zahir, Zahir Ahmad; Shahid, Muhammad

2018-03-01

Present study was conducted to evaluate the effect of lead tolerant plant growth promoting rhizobacteria (LTPGPR) on growth, physiology, yield, antioxidant activities and lead uptake in sunflower in soil contaminated with lead under pot conditions. Three pre-characterized LTPGP strains (S2 (Pseudomonas gessardii strain BLP141), S5 (Pseudomonas fluorescens A506) and S10 (Pseudomonas fluorescens strain LMG 2189)) were used to inoculate sunflower growing in soil contaminated with different levels (300, 600 and 900 mg kg -1 ) of lead by using lead nitrate salt as source of lead. Treatments were arranged according to completely randomized design with factorial arrangements. At harvesting, data regarding growth attributes (root shoot length, root shoot fresh and dry weights), yield per plant, physiological attributes (Chlorophyll 'a', 'b' and carotenoids content), antioxidant activities (Ascorbate peroxidase, catalase, superoxide dismutase and glutathione reductase), proline and malanodialdehyde content, and lead content in root, shoot and achenes of sunflower were recorded. Data were analysed by standard statistical procedures. Results showed that lead contamination reduced the plants growth, physiology and yield at all levels of lead stress. But application of LTPGPR in soil contaminated with lead improved plant growth, physiology, yield, and antioxidant activities, proline, and reduced the malanodialdehyde content (that is reduced by the application of different strains in lead contamination) of sunflower as compared to plants grown in soil without inoculation. Inoculation also promoted the uptake of lead in root, shoots and reduced the uptake of lead in achenes of plants as compared to plants in lead contamination without inoculation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Temporal stability of blood lead concentrations in adults exposed only to environmental lead

Energy Technology Data Exchange (ETDEWEB)

Delves, H T; Sherlock, J C; Quinn, M J

1984-08-01

The temporal stability of blood lead concentrations of 21 health adults (14 men and 7 women) exposed only to environmental lead was assessed by analysis of 253 blood specimens collected serially over periods from 7 to 11 months. The women had lower blood lead concentrations (mean 8.5, range 7.4-10.8 micrograms/100 ml) than did the men (mean 12.2, range 8.6-15.8 micrograms/100 ml). These are within the expected ranges for non-occupationally exposed persons. Blood lead concentrations in the serial specimens from both men and women changed very little over the study period, with standard deviations of less than 0.5 micrograms/100 ml for the majority of individual mean concentrations: for all except low subjects the standard deviations were less than 0.8 micrograms/100 ml. Two subjects showed significant changes in blood lead concentrations during the study. A temporary increase in oral lead intake was identified for one of these subjects. In the absence of substantial changes in lead exposure blood lead levels in adults are remarkably stable and for their environmental monitoring a single blood lead concentration is an excellent biological indicator.

Correlations in particle production in proton-lead and lead-lead collisions at the LHC

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00361447

In high-energy heavy-ion collisions at the Large Hadron Collider (LHC), a hot and dense state of matter called the Quark-Gluon Plasma (QGP) is formed. The initial collision geometry and the subsequent expansion during the QGP stage result in the correlations of produced particles, through which the properties of the QGP can be investigated. Two analyses based on the geometrical correlations of produced particles, one in proton-lead (p–Pb) collisions and the other in lead-lead (Pb–Pb) collisions, are presented in this thesis. The data analyzed in this thesis were collected with the ALICE detector at the LHC in p– Pb collisions at a nucleon–nucleon center-of-mass energy of 5.02 TeV, and Pb–Pb collisions at a nucleon–nucleon center-of-mass energy of 2.76 TeV. In the forward-central two-particle correlation analysis in p–Pb collisions, two-particle an- gular correlations between trigger particles in the forward pseudorapidity range (2.5 < |η| < 4.0) and associated particles in the central ran...

Levels and source apportionment of children's lead exposure: could urinary lead be used to identify the levels and sources of children's lead pollution?

Science.gov (United States)

Cao, Suzhen; Duan, Xiaoli; Zhao, Xiuge; Wang, Beibei; Ma, Jin; Fan, Delong; Sun, Chengye; He, Bin; Wei, Fusheng; Jiang, Guibin

2015-04-01

As a highly toxic heavy metal, the pollution and exposure risks of lead are of widespread concern for human health. However, the collection of blood samples for use as an indicator of lead pollution is not always feasible in most cohort or longitudinal studies, especially those involving children health. To evaluate the potential use of urinary lead as an indicator of exposure levels and source apportionment, accompanying with environmental media samples, lead concentrations and isotopic measurements (expressed as (207)Pb/(206)Pb, (208)Pb/(206)Pb and (204)Pb/(206)Pb) were investigated and compared between blood and urine from children living in the vicinities of a typical coking plant and lead-acid battery factory. The results showed urinary lead might not be a preferable proxy for estimating blood lead levels. Fortunately, urinary lead isotopic measurements could be used as an alternative for identifying the sources of children's lead exposure, which coincided well with the blood lead isotope ratio analysis. Copyright © 2015 Elsevier Ltd. All rights reserved.

Determining tissue-lead levels in large game mammals harvested with lead bullets: human health concerns.

Science.gov (United States)

Tsuji, L J S; Wainman, B C; Jayasinghe, R K; VanSpronsen, E P; Liberda, E N

2009-04-01

Recently, the use of lead isotope ratios has definitively identified lead ammunition as a source of lead exposure for First Nations people, but the isotope ratios for lead pellets and bullets were indistinguishable. Thus, lead-contaminated meat from game harvested with lead bullets may also be contributing to the lead body burden; however, few studies have determined if lead bullet fragments are present in big game carcasses. We found elevated tissue-lead concentrations (up to 5,726.0 microg/g ww) in liver (5/9) and muscle (6/7) samples of big game harvested with lead bullets and radiographic evidence of lead fragments. Thus, we would advise that the tissue surrounding the wound channel be removed and discarded, as this tissue may be contaminated by lead bullet fragments.

Lead intoxication in dogs: risk assessment of feeding dogs trimmings of lead-shot game.

Science.gov (United States)

Høgåsen, Helga R; Ørnsrud, Robin; Knutsen, Helle K; Bernhoft, Aksel

2016-07-25

Expanding lead-based bullets, commonly used for hunting of big game, produce a scattering of lead particles in the carcass around the wound channel. Trimmings around this channel, which are sometimes fed to dogs, may contain lead particles. The aim of this study was to assess potential health effects of feeding dogs such trimmings. Lead ingestion most commonly causes gastrointestinal and neurological clinical signs, although renal, skeletal, haematological, cardiovascular and biochemical effects have also been reported. Experimental data indicate that a daily dose of around 1 mg lead as lead acetate/kg body weight for ten days may be considered as a Lowest Observed Effect Level in dogs. Acute toxicity documentation from the Centers for Disease Control and Prevention indicates 300 mg/kg body weight as the lowest dose of lead acetate causing death in dogs after oral ingestion. Our assessment suggests that dogs fed trimmings of lead-shot game may be affected by the amounts of lead present, and that even deadly exposure could occasionally occur. The intestinal absorption of lead from bullets was assumed to be 10-80 % of that of lead acetate, reflecting both the variability in particle size and uncertainty about the bioavailability of metallic lead in dogs. Despite data gaps, this study indicates that feeding dogs trimmings of lead-shot game may represent a risk of lead intoxication. More research is needed to assess the exact consequences, if lead-based bullets are still to be used. Meanwhile, we recommend that trimmings close to the wound channel should be made inaccessible to dogs, as well as to other domestic or wild animals.

NA49: lead-lead collision

CERN Multimedia

1996-01-01

This is an image of an actual lead ion collision taken from tracking detectors on the NA49 experiment, part of the heavy ion project at CERN. These collisions produce a very complicated array of hadrons as the heavy ions break up. It is hoped that one of these collisions will eventually create a new state of matter known as quark-gluon plasma.

Eryptosis in lead-exposed workers

International Nuclear Information System (INIS)

Aguilar-Dorado, Itzel-Citlalli; Hernández, Gerardo; Quintanar-Escorza, Martha-Angelica; Maldonado-Vega, María; Rosas-Flores, Margarita; Calderón-Salinas, José-Víctor

2014-01-01

Eryptosis is a physiological phenomenon in which old and damaged erythrocytes are removed from circulation. Erythrocytes incubated with lead have exhibited major eryptosis. In the present work we found evidence of high levels of eryptosis in lead exposed workers possibly via oxidation. Blood samples were taken from 40 male workers exposed to lead (mean blood lead concentration 64.8 μg/dl) and non-exposed workers (4.2 μg/dl). The exposure to lead produced an intoxication characterized by 88.3% less δ-aminolevulinic acid dehydratase (δALAD) activity in lead exposed workers with respect to non-lead exposed workers. An increment of oxidation in lead exposed workers was characterized by 2.4 times higher thiobarbituric acid-reactive substance (TBARS) concentration and 32.8% lower reduced/oxidized glutathione (GSH/GSSG) ratio. Oxidative stress in erythrocytes of lead exposed workers is expressed in 192% higher free calcium concentration [Ca 2+ ] i and 1.6 times higher μ-calpain activity with respect to non-lead exposed workers. The adenosine triphosphate (ATP) concentration was not significantly different between the two worker groups. No externalization of phosphatidylserine (PS) was found in non-lead exposed workers (< 0.1%), but lead exposed workers showed 2.82% externalization. Lead intoxication induces eryptosis possibly through a molecular pathway that includes oxidation, depletion of reduced glutathione (GSH), increment of [Ca 2+ ], μ-calpain activation and externalization of PS in erythrocytes. Identifying molecular signals that induce eryptosis in lead intoxication is necessary to understand its physiopathology and chronic complications. - Graphical abstract: Fig. 1. (A) Blood lead concentration (PbB) and (B) phosphatidylserine externalization on erythrocyte membranes of non-lead exposed (□) and lead exposed workers (■). Values are mean ± SD. *Significantly different (P < 0.001). - Highlights: • Erythrocytes of lead exposed workers showed higher PS

Eryptosis in lead-exposed workers

Energy Technology Data Exchange (ETDEWEB)

Aguilar-Dorado, Itzel-Citlalli [Biochemistry Department, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico); Hernández, Gerardo [Section of Methodology of Science, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico); Quintanar-Escorza, Martha-Angelica [Faculty of Medicine, UJED, Durango, DGO (Mexico); Maldonado-Vega, María [CIATEC, León, GTO (Mexico); Rosas-Flores, Margarita [Biochemistry Department, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico); Calderón-Salinas, José-Víctor, E-mail: jcalder@cinvestav.mx [Biochemistry Department, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico)

2014-12-01

Eryptosis is a physiological phenomenon in which old and damaged erythrocytes are removed from circulation. Erythrocytes incubated with lead have exhibited major eryptosis. In the present work we found evidence of high levels of eryptosis in lead exposed workers possibly via oxidation. Blood samples were taken from 40 male workers exposed to lead (mean blood lead concentration 64.8 μg/dl) and non-exposed workers (4.2 μg/dl). The exposure to lead produced an intoxication characterized by 88.3% less δ-aminolevulinic acid dehydratase (δALAD) activity in lead exposed workers with respect to non-lead exposed workers. An increment of oxidation in lead exposed workers was characterized by 2.4 times higher thiobarbituric acid-reactive substance (TBARS) concentration and 32.8% lower reduced/oxidized glutathione (GSH/GSSG) ratio. Oxidative stress in erythrocytes of lead exposed workers is expressed in 192% higher free calcium concentration [Ca{sup 2+}]{sub i} and 1.6 times higher μ-calpain activity with respect to non-lead exposed workers. The adenosine triphosphate (ATP) concentration was not significantly different between the two worker groups. No externalization of phosphatidylserine (PS) was found in non-lead exposed workers (< 0.1%), but lead exposed workers showed 2.82% externalization. Lead intoxication induces eryptosis possibly through a molecular pathway that includes oxidation, depletion of reduced glutathione (GSH), increment of [Ca{sup 2+}], μ-calpain activation and externalization of PS in erythrocytes. Identifying molecular signals that induce eryptosis in lead intoxication is necessary to understand its physiopathology and chronic complications. - Graphical abstract: Fig. 1. (A) Blood lead concentration (PbB) and (B) phosphatidylserine externalization on erythrocyte membranes of non-lead exposed (□) and lead exposed workers (■). Values are mean ± SD. *Significantly different (P < 0.001). - Highlights: • Erythrocytes of lead exposed workers

Investigation of coolant mixing in WWER-440/213 RPV with improved turbulence model

International Nuclear Information System (INIS)

Kiss, B.; Aszodi, A.

2011-01-01

A detailed and complex RPV model of WWER-440/213 type reactor was developed in Budapest University of Technology and Economics Institute of Nuclear Techniques in the previous years. This model contains the main structural elements as inlet and outlet nozzles, guide baffles of hydro-accumulators coolant, alignment drifts, perforated plates, brake- and guide tube chamber and simplified core. With the new vessel model a series of parameter studies were performed considering turbulence models, discretization schemes, and modeling methods with ANSYS CFX. In the course of parameter studies the coolant mixing was investigated in the RPV. The coolant flow was 'traced' with different scalar concentration at the inlet nozzles and its distribution was calculated at the core bottom. The simulation results were compared with PAKS NPP measured mixing factors data (available from FLOMIX project. Based on the comparison the SST turbulence model was chosen for the further simulations, which unifies the advantages of two-equation (kω and kε) models. The most widely used turbulence models are Reynolds-averaged Navier-Stokes models that are based on time-averaging of the equations. Time-averaging filters out all turbulent scales from the simulation, and the effect of turbulence on the mean flow is then re-introduced through appropriate modeling assumptions. Because of this characteristic of SST turbulence model a decision was made in year 2011 to investigate the coolant mixing with improved turbulence model as well. The hybrid SAS-SST turbulence model was chosen, which is capable of resolving large scale turbulent structures without the time and grid-scale resolution restrictions of LES, often allowing the use of existing grids created for Reynolds-averaged Navier-Stokes simulations. As a first step the coolant mixing was investigated in the downcomer only. Eddies are occurred after the loop connection because of the steep flow direction change. This turbulent, vertiginous flow was

“Lead Leached into Water from Select Plumbing Fixtures” Could Lead to Health Hazard

Directory of Open Access Journals (Sweden)

Ramsey Coles

2014-01-01

Full Text Available Background: Lead is an inert metal and is resistant to corrosion. It also increases tensile strength of many common materials in daily use. Lead was used during the Roman period to transport water (hence the name plumbing/plumber is common terminology even in the present day. Lead enters the biological system through the air, water, and dust. Fine particles of lead, having diameter less than 5 nm are directly absorbed by lungs. Inorganic lead is absorbed by the gastrointestinal tract, and organic lead is absorbed by the skin. Lead has long been known to be a toxic heavy metal and exposure is associated with many deleterious health effects. Still, lead remains a popular ingredient in products ranging from paint to batteries. The lead content in any given material is estimated using various methods. The least cumbersome method is found to be X-Ray Fluorescence technique (XRF. A portable XRF device was used in the present study. Aim: The main aim of this study to investigate whether lead is present in various commonly used plumbing materials. Material and Methods: All types of branded and commonly used pipes were gathered from a market in Bangalore and tested using the XRF machine. In order to evaluate to what extent lead from the pipes could leach into water, seven pipes were randomly selected and filled with Aquafina water (having undetectable level of lead for a 24 hour period. This water was tested at an NABL accredited laboratory in Bangalore, India for lead content. Result: It was determined that lead was present in many of the samples, at an unacceptable levels ranging from, well above the globally accepted level of 0.01 mg/L proof that lead was able to leach from the samples into water. Conclusions: As lead in drinking water represents a direct pathway for human exposure, the authors recommend that significant measures be taken to prevent use of lead in the plumbing industry for prevention of it’s deleterious effects. Authors have also

Lead Poison Detection

Science.gov (United States)

1976-01-01

With NASA contracts, Whittaker Corporations Space Science division has developed an electro-optical instrument to mass screen for lead poisoning. Device is portable and detects protoporphyrin in whole blood. Free corpuscular porphyrins occur as an early effect of lead ingestion. Also detects lead in urine used to confirm blood tests. Test is inexpensive and can be applied by relatively unskilled personnel. Similar Whittaker fluorometry device called "drug screen" can measure morphine and quinine in urine much faster and cheaper than other methods.

Lead remediation and changes in human lead exposure: some physiological and biokinetic dimensions.

Science.gov (United States)

Mushak, Paul

2003-02-15

This paper presents a qualitative and quantitative analysis of the various aspects of lead remediation effectiveness with particular reference to human health risk assessment. One of the key elements of lead remediation efforts at such sites as those under the Superfund program deals with populations at elevated exposure and toxicity risk in the proximity of, or at, the site of remediation, especially remediation workers, workers at other tasks on sites that were remediated down to some action level of lead concentration in soils, and groups at risk in nearby communities. A second element has to do with how one measures or models lead exposure changes with special reference to baseline and post-remediation conditions. Various biomarkers of lead exposure can be employed, but their use requires detailed knowledge of what results using each means. The most commonly used approach is measurement of blood lead (Pb-B). Recognized limitations in the use of Pb-B has led to the use of predictive Pb exposure models, which are less vulnerable to the many behavioral, physiological, and environmental parameters that can distort isolated or 'single shot' Pb-B testings. A third aspect covered in this paper presents various physiological factors that affect the methods by which one evaluates Pb remediation effectiveness. Finally, this article offers an integrated look at how lead remediation actions directed at one lead source or pathway affect the total lead exposure picture for human populations at elevated lead exposure and toxicity risk.

Superconductivity in nanostructured lead

Science.gov (United States)

Lungu, Anca; Bleiweiss, Michael; Amirzadeh, Jafar; Saygi, Salih; Dimofte, Andreea; Yin, Ming; Iqbal, Zafar; Datta, Timir

2001-01-01

Three-dimensional nanoscale structures of lead were fabricated by electrodeposition of pure lead into artificial porous opal. The size of the metallic regions was comparable to the superconducting coherence length of bulk lead. Tc as high as 7.36 K was observed, also d Tc/d H was 2.7 times smaller than in bulk lead. Many of the characteristics of these differ from bulk lead, a type I superconductor. Irreversibility line and magnetic relaxation rates ( S) were also studied. S( T) displayed two maxima, with a peak value about 10 times smaller than that of typical high- Tc superconductors.

TAREG 2.01/00 Project, ''Validation of neutron embrittlement for VVER 1000 and 440/213 RPVs, with emphasis on integrity assessment''

International Nuclear Information System (INIS)

Ahlstrand, R.; Margolin, B.; Kostylev, V.; Yurchenko, E.; Akbashev, I.; Piminov, V.; Nikolaev, Y.; Koshkin, V.; Kharshenko, V.; Chyrko, L.; Bukhanov, V.; Comsa, O.

2012-01-01

The irradiation embrittlement and integrity of the VVER reactors has been an important issue in many EC supported TACIS and PHARE projects since 1990. In the EC annual program 2000 two TACIS projects (TAREG 2.01/00 and 2.01/03) were approved on the issue in order to improve the neutron irradiation embrittlement databases, elaborate new trend curves for the embrittlement and to assess the integrity of the RPVs (Reactor Pressure Vessel) by analysing PTS transients (Pressurized Thermal Shock) for some selected Russian and Ukrainian VVER 1000 and 440/213 NPPs. In this paper the TAREG 2.01/00 project is briefly described with some details from the twin project 2.01/03, which served as a materials testing project, providing inputs for the 1st project. As a result of the project new trend curves for neutron irradiation embrittlement were elaborated, based on upgraded and more reliable surveillance results databases. The PTS study shows that the integrity of the selected VVER RPVs can be ensured to the end of RPV design life. (author)

Lead (Pb) Air Pollution

Science.gov (United States)

... Regional Offices Labs and Research Centers Lead (Pb) Air Pollution Contact Us Share As a result of EPA's ... and protect aquatic and terrestrial ecosystems. Lead (Pb) Air Pollution Basic Information How does lead get in the ...

Lead poisoning: The invisible disease

Science.gov (United States)

Friend, Milton

1989-01-01

Lead poisoning is an intoxication resulting from absorption of hazardous levels of lead into body tissues. Lead pellets from shot shells, when ingested, are the most common source of lead poisoning in migratory birds. Other far less common sources include lead fishing sinkers, mine wastes, paint pigments, bullets, and other lead objects that are swallowed.

Taking the Lead : Gender, Social Context and Preference to Lead

NARCIS (Netherlands)

Hong, A.P.C.I.; Schaafsma, J.; van der Wijst, P.J.

2014-01-01

Previous research has demonstrated that women tend to emerge as leaders less often than men. In the present study, we examined to what extent women's and men's preference to lead is influenced by social context. It was hypothesized that women have a less strong preference to lead than men in a

Biological fractionation of lead isotopes in Sprague-Dawley rats lead poisoned via the respiratory tract.

Directory of Open Access Journals (Sweden)

Jing Wu

Full Text Available It was considered that lead isotope ratios did not change during physical, chemical, or biological processes. Thus, lead isotope ratios have been used as fingerprints to identify possible lead sources. However, recent evidence has shown that the lead isotope ratios among different biological samples in human are not always identical from its lead origins in vitro. An animal experiment was conducted to explore the biological fractionation of lead isotopes in biological systems.24 male Sprague-Dawley (SD rats were divided into groups that received acute lead exposure (0, 0.02, 0.2, or 2 mg/kg body weight of lead acetate via the respiratory route every day for 5 days. Biological samples (i.e., blood, urine, and feces were collected for comparison with the lead acetate (test substance and the low-lead animal feed (diet administered to the rats. The lead isotope ratios were determined by inductively coupled plasma mass spectrometry (ICP-MS.There are significant differences (p<0.05 in lead isotope ratios between blood, urine, and feces. Moreover, a nonlinear relationship between the blood lead concentration and the blood lead isotope ratios was observed. There is also a threshold effect to the fractionation function. Only the blood isotope ratio of (204Pb/(206Pb matches the test substance well. As for feces, when (204Pb/(206Pb ratio is considered, there is no significant difference between feces-test substance pairs in medium and high dose group.The biological fractionation of lead isotopes in SD rats was observed. Moreover, there might be a threshold for the biological fractionation of lead isotopes which is depending on whole blood lead level. It is considered to be more reliable that we compared the isotope ratios of potential lead hazards with both blood and feces lead fingerprints especially for (204Pb/(206Pb ratio under high-dose exposure.

Preventive maintenance basis: Volume 24 -- Battery -- flooded lead-acid (lead-calcium, lead antimony, plante). Final report

International Nuclear Information System (INIS)

Worledge, D.; Hinchcliffe, G.

1997-12-01

US nuclear power plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This document provides a program of preventive maintenance tasks suitable for application to flooded lead-acid batteries. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used in conjunction with material from other sources, to develop a complete PM program or to improve an existing program. This document provides a program of preventive maintenance (PM) tasks suitable for application to flooded lead-acid batteries. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used, in conjunction with material from other sources, to develop a complete PM program or to improve an existing program. Users of this information will be utility managers, supervisors, system engineers, craft technicians, and training instructors responsible for developing, optimizing, or fine-tuning PM programs

Lead-Binding Proteins: A Review

Directory of Open Access Journals (Sweden)

Harvey C. Gonick

2011-01-01

Full Text Available Lead-binding proteins are a series of low molecular weight proteins, analogous to metallothionein, which segregate lead in a nontoxic form in several organs (kidney, brain, lung, liver, erythrocyte. Whether the lead-binding proteins in every organ are identical or different remains to be determined. In the erythrocyte, delta-aminolevulinic acid dehydratase (ALAD isoforms have commanded the greatest attention as proteins and enzymes that are both inhibitable and inducible by lead. ALAD-2, although it binds lead to a greater degree than ALAD-1, appears to bind lead in a less toxic form. What may be of greater significance is that a low molecular weight lead-binding protein, approximately 10 kDa, appears in the erythrocyte once blood lead exceeds 39 μg/dL and eventually surpasses the lead-binding capacity of ALAD. In brain and kidney of environmentally exposed humans and animals, a cytoplasmic lead-binding protein has been identified as thymosin β4, a 5 kDa protein. In kidney, but not brain, another lead-binding protein has been identified as acyl-CoA binding protein, a 9 kDa protein. Each of these proteins, when coincubated with liver ALAD and titrated with lead, diminishes the inhibition of ALAD by lead, verifying their ability to segregate lead in a nontoxic form.

Gas cooled leads

International Nuclear Information System (INIS)

Shutt, R.P.; Rehak, M.L.; Hornik, K.E.

1993-01-01

The intent of this paper is to cover as completely as possible and in sufficient detail the topics relevant to lead design. The first part identifies the problems associated with lead design, states the mathematical formulation, and shows the results of numerical and analytical solutions. The second part presents the results of a parametric study whose object is to determine the best choice for cooling method, material, and geometry. These findings axe applied in a third part to the design of high-current leads whose end temperatures are determined from the surrounding equipment. It is found that cooling method or improved heat transfer are not critical once good heat exchange is established. The range 5 5 but extends over a large of values. Mass flow needed to prevent thermal runaway varies linearly with current above a given threshold. Below that value, the mass flow is constant with current. Transient analysis shows no evidence of hysteresis. If cooling is interrupted, the mass flow needed to restore the lead to its initially cooled state grows exponentially with the time that the lead was left without cooling

EPA Leads the Way on Lead Exposure Science and Risk Management

Science.gov (United States)

EPA researchers have developed a modeling approach that improves our understanding of the relationship between lead concentrations of various sources (drinking water, soil and dust, food, and air) and children’s blood-lead levels.

Lead Poisoning (For Parents)

Science.gov (United States)

... Staying Safe Videos for Educators Search English Español Lead Poisoning KidsHealth / For Parents / Lead Poisoning What's in ... Print en español La intoxicación por plomo About Lead Poisoning If you have young kids, it's important ...

VOLUMETRIC LEAD ASSAY

International Nuclear Information System (INIS)

Ebadian, M.A.; Dua, S.K.; Roelant, David; Kumar, Sachin

2001-01-01

This report describes a system for handling and radioassay of lead, consisting of a robot, a conveyor, and a gamma spectrometer. The report also presents a cost-benefit analysis of options: radioassay and recycling lead vs. disposal as waste

EMERGING TECHNOLOGY BULLETIN: RECLAMATION OF LEAD FROM SUPERFUND WASTE MATERIAL USING SECONDARY LEAD SMELTERS

Science.gov (United States)

This process involves incorporating lead-contaminated Superfund waste with the regular feed to a secondary lead smelter. Since secondary lead smelters already recover lead from recycled automobile batteries, it seems likely that this technology could be used to treat waste from ...

Biological fractionation of lead isotopes in Sprague-Dawley rats lead poisoned via the respiratory tract.

Science.gov (United States)

Wu, Jing; Liu, Duojian; Xie, Qing; Wang, Jingyu

2012-01-01

It was considered that lead isotope ratios did not change during physical, chemical, or biological processes. Thus, lead isotope ratios have been used as fingerprints to identify possible lead sources. However, recent evidence has shown that the lead isotope ratios among different biological samples in human are not always identical from its lead origins in vitro. An animal experiment was conducted to explore the biological fractionation of lead isotopes in biological systems. 24 male Sprague-Dawley (SD) rats were divided into groups that received acute lead exposure (0, 0.02, 0.2, or 2 mg/kg body weight of lead acetate) via the respiratory route every day for 5 days. Biological samples (i.e., blood, urine, and feces) were collected for comparison with the lead acetate (test substance) and the low-lead animal feed (diet) administered to the rats. The lead isotope ratios were determined by inductively coupled plasma mass spectrometry (ICP-MS). There are significant differences (pblood, urine, and feces. Moreover, a nonlinear relationship between the blood lead concentration and the blood lead isotope ratios was observed. There is also a threshold effect to the fractionation function. Only the blood isotope ratio of (204)Pb/(206)Pb matches the test substance well. As for feces, when (204)Pb/(206)Pb ratio is considered, there is no significant difference between feces-test substance pairs in medium and high dose group. The biological fractionation of lead isotopes in SD rats was observed. Moreover, there might be a threshold for the biological fractionation of lead isotopes which is depending on whole blood lead level. It is considered to be more reliable that we compared the isotope ratios of potential lead hazards with both blood and feces lead fingerprints especially for (204)Pb/(206)Pb ratio under high-dose exposure.

Two cases of acute lead poisoning due to occupational exposure to lead.

Science.gov (United States)

Ogawa, Masanori; Nakajima, Yoshiaki; Kubota, Ryuichi; Endo, Yoko

2008-04-01

We experienced two cases of acute lead poisoning due to occupational exposure to lead. The patients were engaged in stripping off antirust compounds including Pb from a bridge and re-painting it at the same work place. Both patients exhibited colic, arthralgia, and anemia. Blood lead levels were 73.1 microg/dl and 96.3 microg/dl. Intravenous CaEDTA chelation therapy was therefore performed. After chelation, blood lead levels decreased and symptoms gradually disappeared. Although the patients were working with protective equipment, the workplace was in the mountains and there was no water for washing. The patients were thus unable to washing their hands and faces. We assume that they swallowed lead dust left on their hands and faces when they removed their clothing, and believe that this poisoning occurred due to lack of knowledge sufficient for protection.

Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses.

Science.gov (United States)

Wang, Xiao-Chun; Wang, Jian; Tao, Hui-Hui; Zhang, Chao; Xu, Li-Fa

2017-07-14

Objectives: Cigarette smoking is the major risk factor of bladder cancer via exposure to chemical carcinogens. Nicotinamide adenine dinucleotide phosphate (NADP+): quinine oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) have been reported to involve in the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Therefore, the risk of bladder cancer (BC) may be influenced by polymorphisms in the genes that modulate metabolic detoxification in particular by interacting with cigarette smoking. Considering the limited power by the individual studies with a relatively small sample size, especially when analyzing the combined effect of polymorphisms in NQO1 and SULT1A1 genes and smoking, these 2 meta-analyses have aimed to clarify the combined effects of them on BC risk by integrating related studies. Two meta-analyses included 1341 cases and 1346 controls concerning NQO1 Pro187Ser and smoking, and 1921 cases and 1882 controls on SULT1A1 Arg213His and smoking were performed. Odds ratios (OR) and 95% confidence intervals (CI) were used for assessing the strength of the association. The result has demonstrated that smokers with NQO1 Pro/Ser or Ser/Ser genotypes have a prominent association with the risk of BC as compared with non-smokers with NQO1 Pro/Pro genotype, with OR equal to 3.71 (95% CI: 2.87-4.78, pheterogeneity = 0.376). Besides, smokers carrying SULT1A1 Arg/Arg genotypes were observed to confer 2.38 fold increased risk of BC (95% CI: 1.44-3.93, pheterogeneity = 0.001) when compared with non-smokers with SULT1A1 Arg/Arg or His/His genotypes. These findings have suggested that the NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism combination with smoking significantly confer susceptibility to BC. Int J Occup Med Environ Health 2017;30(5):791-802. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses

Directory of Open Access Journals (Sweden)

Xiao-Chun Wang

2017-10-01

Full Text Available Objectives: Objectives: Cigarette smoking is the major risk factor of bladder cancer via exposure to chemical carcinogens. Nicotinamide adenine dinucleotide phosphate (NADP+: quinine oxidoreductase 1 (NQO1 and sulfotransferase 1A1 (SULT1A1 have been reported to involve in the metabolism of polycyclic aromatic hydrocarbons (PAHs and aromatic amines. Therefore, the risk of bladder cancer (BC may be influenced by polymorphisms in the genes that modulate metabolic detoxification in particular by interacting with cigarette smoking. Considering the limited power by the individual studies with a relatively small sample size, especially when analyzing the combined effect of polymorphisms in NQO1 and SULT1A1 genes and smoking, these 2 meta-analyses have aimed to clarify the combined effects of them on BC risk by integrating related studies. Material and Methods: Two meta-analyses included 1341 cases and 1346 controls concerning NQO1 Pro187Ser and smoking, and 1921 cases and 1882 controls on SULT1A1 Arg213His and smoking were performed. Odds ratios (OR and 95% confidence intervals (CI were used for assessing the strength of the association. Results: The result has demonstrated that smokers with NQO1 Pro/Ser or Ser/Ser genotypes have a prominent association with the risk of BC as compared with non-smokers with NQO1 Pro/Pro genotype, with OR equal to 3.71 (95% CI: 2.87–4.78, pheterogeneity = 0.376. Besides, smokers carrying SULT1A1 Arg/Arg genotypes were observed to confer 2.38 fold increased risk of BC (95% CI: 1.44–3.93, pheterogeneity = 0.001 when compared with non-smokers with SULT1A1 Arg/Arg or His/His genotypes. Conclusions: These findings have suggested that the NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism combination with smoking significantly confer susceptibility to BC. Int J Occup Med Environ Health 2017;30(5:791–802

Arkansas People Participating in Lead Education (APPLE): results of a lead-safe training program.

Science.gov (United States)

Ferguson, Alesia; Bursac, Zoran; Kern, David F

2011-06-01

Lead is still seen as one of the most harmful environmental toxins for young children, with the predominant source being deteriorating lead-based paint. Those at continued risk include those living in homes built before 1978, renovators and remodelers, and especially those with limited access to proper healthcare and diets. Proper training on lead-safe work practices focused on preventing and reducing the spread of lead dust can help reduce lead exposure. Presented in this paper are experiences in delivering lead-safe work practices training in six Arkansas cities, and results from pre- and post- surveys delivered before and immediately after the training. Pre- and post-surveys assess strong and weak areas of training. Participants demonstrated positive shifts in attitude and behavior towards lead-safe work practices following training. However, our research found that more emphasis should be focused on clarifying current lead exposure sources and routes for children.

Lead contamination and transfer in urban environmental compartments analyzed by lead levels and isotopic compositions

International Nuclear Information System (INIS)

Hu, Xin; Sun, Yuanyuan; Ding, Zhuhong; Zhang, Yun; Wu, Jichun; Lian, Hongzhen; Wang, Tijian

2014-01-01

Lead levels and isotopic compositions in atmospheric particles (TSP and PM 2.5 ), street dust and surface soil collected from Nanjing, a mega city in China, were analyzed to investigate the contamination and the transfer of lead in urban environmental compartments. The lead contents in TSP and PM 2.5 are significantly higher than them in the surface soil and street dust (p  206 Pb/ 207 Pb vs. 208 Pb/ 206 Pb and 206 Pb/ 207 Pb vs. 1/Pb imply that the street dust and atmospheric particles (TSP and PM 2.5 ) have very similar lead sources. Coal emissions and smelting activities may be the important lead sources for street dust and atmospheric particles (TSP and PM 2.5 ), while the deposition of airborne lead is an important lead source for urban surface soil. - Highlights: • Lead levels and isotope ratios in atmospheric particles, street dust and surface soil. • Significant enrichment of lead in atmospheric particles was observed. • Street dust and atmospheric particles have similar lead sources. • Endmembers of soil lead differ from street dust and atmospheric particles. • Airborne lead poses the main risks to unban environmental quality. - Transfer of airborne particle bound lead into street dust and surface soil in unban environmental based on lead levels and isotopic compositions

Compact Solid-State 213 nm Laser Enables Standoff Deep Ultraviolet Raman Spectrometer: Measurements of Nitrate Photochemistry.

Science.gov (United States)

Bykov, Sergei V; Mao, Michael; Gares, Katie L; Asher, Sanford A

2015-08-01

We describe a new compact acousto-optically Q-switched diode-pumped solid-state (DPSS) intracavity frequency-tripled neodymium-doped yttrium vanadate laser capable of producing ~100 mW of 213 nm power quasi-continuous wave as 15 ns pulses at a 30 kHz repetition rate. We use this new laser in a prototype of a deep ultraviolet (UV) Raman standoff spectrometer. We use a novel high-throughput, high-resolution Echelle Raman spectrograph. We measure the deep UV resonance Raman (UVRR) spectra of solid and solution sodium nitrate (NaNO3) and ammonium nitrate (NH4NO3) at a standoff distance of ~2.2 m. For this 2.2 m standoff distance and a 1 min spectral accumulation time, where we only monitor the symmetric stretching band, we find a solid state NaNO3 detection limit of ~100 μg/cm(2). We easily detect ~20 μM nitrate water solutions in 1 cm path length cells. As expected, the aqueous solutions UVRR spectra of NaNO3 and NH4NO3 are similar, showing selective resonance enhancement of the nitrate (NO3(-)) vibrations. The aqueous solution photochemistry is also similar, showing facile conversion of NO3(-) to nitrite (NO2(-)). In contrast, the observed UVRR spectra of NaNO3 and NH4NO3 powders significantly differ, because their solid-state photochemistries differ. Whereas solid NaNO3 photoconverts with a very low quantum yield to NaNO2, the NH4NO3 degrades with an apparent quantum yield of ~0.2 to gaseous species.

Lead pollution sources and Impacts

International Nuclear Information System (INIS)

El-Haggar, S.M.; Saad, S.G.; Saleh, S.K.; El-Kady, M.A.

1996-01-01

Despite the medical awareness of lead toxicity, and despite legislation designed to reduce environmental contamination, lead is one of the most widely used heavy metals. Significant human exposure occurs from automobile exhaust fumes, cigarette smoking, lead-based paints and plumbing systems lead spread in the environment can take place in several ways, the most important of which is through the lead compounds released in automobile exhaust as a direct result of the addition of tetraethyl or tetraethyl lead to gasoline as octane boosting agents. Of special is the effect of lead pollution on children, which affects their behavioral and educational attributes considerably. The major channel through through which lead is absorbed is through inhalation of lead compounds in the atmosphere. Lead is a heavy metal characterized its malleability, ductility and poor conduction of electricity. So, it has a wide range of applications ranging from battery manufacturing to glazing ceramics. It is rarely found free in nature but is present in several minerals and compounds. The aim of this paper is to discuss natural and anthropogenic sources of lead together with its distribution and trends with emphasis on egypt. The effects of lead pollution on human health, vegetation and welfare are also presented. It could be concluded that, the excessive release of lead into the environment, especially through the atmosphere, can produce many detrimental and sometimes fatal effects on human, agriculture and zoological life. Besides, it is very plain that there is a serious problem of pollution lead in egypt and specially in cairo. 7 figs

Eryptosis in lead-exposed workers.

Science.gov (United States)

Aguilar-Dorado, Itzel-Citlalli; Hernández, Gerardo; Quintanar-Escorza, Martha-Angelica; Maldonado-Vega, María; Rosas-Flores, Margarita; Calderón-Salinas, José-Víctor

2014-12-01

Eryptosis is a physiological phenomenon in which old and damaged erythrocytes are removed from circulation. Erythrocytes incubated with lead have exhibited major eryptosis. In the present work we found evidence of high levels of eryptosis in lead exposed workers possibly via oxidation. Blood samples were taken from 40 male workers exposed to lead (mean blood lead concentration 64.8μg/dl) and non-exposed workers (4.2μg/dl). The exposure to lead produced an intoxication characterized by 88.3% less δ-aminolevulinic acid dehydratase (δALAD) activity in lead exposed workers with respect to non-lead exposed workers. An increment of oxidation in lead exposed workers was characterized by 2.4 times higher thiobarbituric acid-reactive substance (TBARS) concentration and 32.8% lower reduced/oxidized glutathione (GSH/GSSG) ratio. Oxidative stress in erythrocytes of lead exposed workers is expressed in 192% higher free calcium concentration [Ca(2+)]i and 1.6 times higher μ-calpain activity with respect to non-lead exposed workers. The adenosine triphosphate (ATP) concentration was not significantly different between the two worker groups. No externalization of phosphatidylserine (PS) was found in non-lead exposed workers (lead exposed workers showed 2.82% externalization. Lead intoxication induces eryptosis possibly through a molecular pathway that includes oxidation, depletion of reduced glutathione (GSH), increment of [Ca(2+)], μ-calpain activation and externalization of PS in erythrocytes. Identifying molecular signals that induce eryptosis in lead intoxication is necessary to understand its physiopathology and chronic complications. Copyright © 2014 Elsevier Inc. All rights reserved.

What is lead-based paint?

International Nuclear Information System (INIS)

Vernon, L.S.

1994-01-01

The number of variety of lead-abatement regulations and requirements make it difficult and confusing to identify and properly respond to dangerous levels of lead in every situation. Definitions of ''lead-based paint'' and three test methods for lead detection are described to help determine when and how to test for the presence of lead

Lead identification in soil surrounding a used lead acid battery smelter area in Banten, Indonesia

International Nuclear Information System (INIS)

Adventini, N; Santoso, M; Lestiani, D D; Syahfitri, W Y N; Rixson, L

2017-01-01

A used lead acid battery smelter generates particulates containing lead that can contaminate the surrounding environment area. Lead is a heavy metal which is harmful to health if it enters the human body through soil, air, or water. An identification of lead in soil samples surrounding formal and informal used lead acid battery smelters area in Banten, Indonesia using EDXRF has been carried out. The EDXRF accuracy and precision evaluated from marine sediment IAEA 457 gave a good agreement to the certified value. A number of 16 soil samples from formal and informal areas and 2 soil samples from control area were taken from surface and subsurface soils. The highest lead concentrations from both lead smelter were approximately 9 folds and 11 folds higher than the reference and control samples. The assessment of lead contamination in soils described in C f index was in category: moderately and strongly polluted by lead for formal and informal lead smelter. Daily lead intake of children in this study from all sites had exceeded the recommended dietary allowance. The HI values for adults and children living near both lead smelter areas were greater than the value of safety threshold 1. This study finding confirmed that there is a potential health risk for inhabitants surrounding the used lead acid battery smelter areas in Banten, Indonesia. (paper)

Mechanistic comparison of pulse laser induced phase separation of particulates from cellulose paper at 213 nm and 532 nm

International Nuclear Information System (INIS)

Arif, S.; Forster, M.; Kautek, W.; Bushuk, S.; Kouzmouk, A.; Tatur, H.; Batishche, S.

2013-01-01

The laser-induced phase separation of charcoal particles on additive-free cotton linters cellulose paper was investigated by electron and optical microscopy, colorimetry, and diffuse reflectance FT-IR. The fibre bundles were vaporised in depth of several 10 μm above destruction fluence thresholds using visible 532 nm radiation. This is in contrast to mid-ultraviolet 213 nm radiation, where only the top fibre bundles were modified and partially evaporated. The colorimetric lightness results generally represented the cleaning status, whereas the colorimetric yellowing data represented irreversible chemical and/or photochemical changes. Charcoal-contaminated paper treated with visible and mid-ultraviolet radiation exhibited yellowing, whereas uncontaminated did not. This suggests that the electron-rich plasma generated by the evaporation of the particles heats the adjacent substrate and also excludes oxygen. Mid-ultraviolet, in contrast to visible radiation, shows particle removal always accompanied by paper destruction. IR spectroscopy results suggest cross-linking by ether bonds near the destruction threshold, but do not prove the formation of oxidation products and double bonds as the basis of the yellowing. A ''cleaning window'' between the cleaning threshold (0.1 J/cm 2 ) and the paper destruction threshold (2.9 J/cm 2 ) with a pulse number of 2 is provided by visible 532 nm laser treatment. (orig.)

Stable lead isotopic analyses of historic and contemporary lead contamination of San Francisco Bay estuary

Science.gov (United States)

Ritson, P.I.; Bouse, R.M.; Flegal, A.R.; Luoma, S.N.

1999-01-01

Variations in stable lead isotopic composition (240Pb, 206Pb, 207Pb, 208Pb) in three sediment cores from the San Francisco Bay estuary document temporal changes in sources of lead during the past two centuries. Sediment, with lead from natural geologic sources, and relatively homogeneous lead isotopic compositions are overlain by sediments whose isotopic compositions indicate change in the sources of lead associated with anthropogenic modification of the estuary. The first perturbations of lead isotopic composition in the cores occur in the late 1800s concordant with the beginning of industrialization around the estuary. Large isotopic shifts, toward lower 206Pb/207Pb, occur after the turn of the century in both Richardson and San Pablo Bays. A similar relationship among lead isotopic compositions and lead concentrations in both Bays suggest contamination from the same source (a lead smelter). The uppermost sediments (post 1980) of all cores also have a relatively homogenous lead isotopic composition distinct from pre-anthropogenic and recent aerosol signatures. Lead isotopic compositions of leachates from fourteen surface sediments and five marsh samples from the estuary were also analyzed. These analyses suggest that the lead isotopic signature identified in the upper horizons of the cores is spatially homogeneous among recently deposited sediments throughout the estuary. Current aerosol lead isotopic compositions [Smith, D.R., Niemeyer, S., Flegal, A.R., 1992. Lead sources to California sea otters: industrial inputs circumvent natural lead biodepletion mechanisms. Environmental Research 57, 163-175] are distinct from the isotopic compositions of the surface sediments, suggesting that the major source of lead is cycling of historically contaminated sediments back through the water column. Both the upper core sediments and surface sediments apparently derive their lead predominantly from sources internal to the estuary. These results support the idea that

Heavy flavour production in proton-lead and lead-lead collisions with LHCb

Science.gov (United States)

Winn, Michael

2017-11-01

The LHCb experiment offers the unique opportunity to study heavy-ion interactions in the forward region (2 kinematic domain complementary to the other 3 large experiments at the LHC. The detector has excellent capabilities for reconstructing quarkonia and open charm states, including baryons, down to zero pT. It can separate the prompt and displaced charm components. In pPb collisions, both forward and backward rapidities are covered thanks to the possibility of beam reversal. Results include measurements of the nuclear modification factor and forward-backward ratio for charmonium, open charm and bottomonium states. These quantities are sensitive probes for nuclear effects in heavy flavour production. Perspectives are given with the large accumulated luminosity during the 2016 pPb run at the LHC. In 2015, LHCb participated successfully for the first time in the PbPb data-taking. The status of the forward prompt J/ψ nuclear modification factor measurement in lead-lead collisions is discussed.

Ecotoxicology: Lead

Science.gov (United States)

Scheuhammer, A.M.; Beyer, W.N.; Schmitt, C.J.; Jorgensen, Sven Erik; Fath, Brian D.

2008-01-01

Lead (Pb) is a naturally occurring metallic element; trace concentrations are found in all environmental media and in all living things. However, certain human activities, especially base metal mining and smelting; combustion of leaded gasoline; the use of Pb in hunting, target shooting, and recreational angling; the use of Pb-based paints; and the uncontrolled disposal of Pb-containing products such as old vehicle batteries and electronic devices have resulted in increased environmental levels of Pb, and have created risks for Pb exposure and toxicity in invertebrates, fish, and wildlife in some ecosystems.

Developmental immunotoxicology of lead

International Nuclear Information System (INIS)

Dietert, Rodney R.; Lee, Ji-Eun; Hussain, Irshad; Piepenbrink, Michael

2004-01-01

The heavy metal, lead, is a known developmental immunotoxicant that has been shown to produce immune alterations in humans as well as other species. Unlike many compounds that exert adverse immune effects, lead exposure at low to moderate levels does not produce widespread loss of immune cells. In contrast, changes resulting from lead exposure are subtle at the immune cell population level but, nevertheless, can be functionally dramatic. A hallmark of lead-induced immunotoxicity is a pronounced shift in the balance in T helper cell function toward T helper 2 responses at the expense of T helper 1 functions. This bias alters the nature and range of immune responses that can be produced thereby influencing host susceptibility to various diseases. Immunotoxic responses to lead appear to differ across life stages not only quantitatively with regard to dose response, but also qualitatively in terms of the spectrum of immune alterations. Experimental studies in several lab animal species suggest the latter stages of gestation are a period of considerable sensitivity for lead-induced immunotoxicity. This review describes the basic characteristics of lead-induced immunotoxicity emphasizing experimental animal results. It also provides a framework for the consideration of toxicant exposure effects across life stages. The existence of and probable basis for developmental windows of immune hyper-susceptibility are presented. Finally, the potential for lead to serve as a perinatal risk factor for childhood asthma as well as other diseases is considered

High Burden of Subclinical Lead Toxicity after Phase Out of Lead from Petroleum in Pakistan.

Science.gov (United States)

Majid, Hafsa; Khan, Aysha Habib; Khan, Nadeem Ullah; Siddiqui, Imran; Ghani, Farooq; Jafri, Lena

2017-12-01

To evaluate the frequency of subclinical lead toxicity. Cross-sectional study. Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from January 2011 to December 2014. Analysis of laboratory data for blood lead levels (BLL) was performed. Lead was tested by atomic absorption spectrometer. For all subjects, only initial test results were included while the results of repeated testing were excluded. Exemption was sought from institutional ethical review committee. BLL of 2-10 ug/dl and 10-70 ug/dl in children and adults, respectively were taken as subclinical lead toxicity. Amongst the total number of subjects tested (n=524), 26.5% (n=139) were children (lead level 16.9 ug/dl (36.1-4)] and lower level [4.2 ug/dl (6.8-2.6)] in children with lead levels while most had either subclinical (76%, n=106) or toxic lead levels (8%, n=11). In adults, (55%, n=212) subjects had desired lead levels, and 40% (n=154) and 4.99% (n=19) had subclinical and toxic lead levels. Presence of subclinical lead poisoning even after phasing out of lead petroleum in Pakistanis is alarming, especially in children. A national population-based study to determine the lead status and targeted intervention to identify potential sources is need of the time.

(Na,□)5[MnO2]13 nanorods: a new tunnel structure for electrode materials determined ab initio and refined through a combination of electron and synchrotron diffraction data

Science.gov (United States)

Mugnaioli, Enrico; Gemmi, Mauro; Merlini, Marco; Gregorkiewitz, Michele

2016-01-01

(Nax□1 − x)5[MnO2]13 has been synthesized with x = 0.80 (4), corresponding to Na0.31[MnO2]. This well known material is usually cited as Na0.4[MnO2] and is believed to have a romanèchite-like framework. Here, its true structure is determined, ab initio, by single-crystal electron diffraction tomography (EDT) and refined both by EDT data applying dynamical scattering theory and by the Rietveld method based on synchrotron powder diffraction data (χ2 = 0.690, R wp = 0.051, R p = 0.037, R F2 = 0.035). The unit cell is monoclinic C2/m, a = 22.5199 (6), b = 2.83987 (6), c = 14.8815 (4) Å, β = 105.0925 (16)°, V = 918.90 (4) Å3, Z = 2. A hitherto unknown [MnO2] framework is found, which is mainly based on edge- and corner-sharing octahedra and comprises three types of tunnels: per unit cell, two are defined by S-shaped 10-rings, four by egg-shaped 8-rings, and two by slightly oval 6-rings of Mn polyhedra. Na occupies all tunnels. The so-determined structure excellently explains previous reports on the electrochemistry of (Na,□)5[MnO2]13. The trivalent Mn3+ ions concentrate at two of the seven Mn sites where larger Mn—O distances and Jahn–Teller distortion are observed. One of the Mn3+ sites is five-coordinated in a square pyramid which, on oxidation to Mn4+, may easily undergo topotactic transformation to an octahedron suggesting a possible pathway for the transition among different tunnel structures. PMID:27910840

Lead isotopes reveal different sources of lead in balsamic and other vinegars

International Nuclear Information System (INIS)

Ndung'u, Kuria; Hibdon, Sharon; Veron, Alain; Flegal, A. Russell

2011-01-01

Fifty-eight brands of balsamic vinegars were analyzed for lead concentrations and isotopic compositions ( 204 Pb, 206 Pb, 207 Pb, and 208 Pb) to test the findings of a previous study indicating relatively high levels of lead contamination in some of those vinegars - more than two thirds (70%) of them exceeded California's State Maximum Level (34 μg/L) based on consumption rates ≥ 0.5 μg Pb per day. The Lead isotopic fingerprints of all those vinegars with high lead concentrations were then found to be primarily anthropogenic. This isotopic analysis unquestionably reveals multiple contamination sources including atmospheric pollutant Pb and an unidentified contamination source, likely occurring after grape harvest. Organically grown grape vinegars display the same Pb content and isotopic signatures as other vinegars. This implies that pesticides might not be a significant source of pollutant Pb in vinegars. A significant post-harvest contamination would be inherited from chemicals added during production and/or material used during transport, processing or storage of these vinegars. This is consistent with the highest Pb levels being found in aged vinegars (112 ± 112 μg/L) in contrast to other vinegars (41.6 ± 28.9 μg/L) suggesting contamination during storage. It is, therefore, projected that lead levels in most vinegars, especially aged balsamic and wine vinegars, will decrease with improvements in their manufacture and storage processes consequential to recent concerns of elevated levels of lead in some vinegars. - Highlights: → First extensive study on content and possible sources of lead in balsamic vinegars. → Half of the vinegars exceed California's State Maximum Level for human consumption. → Lead content in vinegars seems to be mainly post-harvest from industrial processes.

Safety and Health Topics: Lead

Science.gov (United States)

... ammunition, pipes, cable covering, building material, solder, radiation shielding, collapsible tubes, and fishing weights. Lead is also ... lead linings in tanks and radiation protection, leaded glass, work involving soldering, and other work involving lead ...

Leading by example to protect the environment : Do the costs of leading matter?

NARCIS (Netherlands)

van der Heijden, E.C.M.; Moxnes, E.

2013-01-01

Environmentalists often urge their home countries to take a leading role in reducing global environmental problems like climate change. A pertinent question is, Will examples set by leading nations influence others to follow suit, and if so, do the costs of leading matter? For instance, will costly

Leading by Example to Protect the Environment; Do the Costs of Leading Matter?

NARCIS (Netherlands)

van der Heijden, E.C.M.; Moxnes, E.

2011-01-01

Environmentalists often urge their home countries to take a leading role in reducing global environmental problems like climate change. A pertinent question is: will examples set by leading nations influence others to follow suit, and if so, do the costs of leading matter? For instance, will costly

The study of spallation reactions, neutron production, and transport in a thick lead target and a uranium blanket during 1.5 GeV proton irradiation

Czech Academy of Sciences Publication Activity Database

Křížek, Filip; Wagner, Vladimír; Adam, Jindřich; Čaloun, Pavel; Henzl, Vladimír; Henzlová, Daniela; Krása, Antonín; Kugler, Andrej; Majerle, Mitja

2006-01-01

Roč. 56, č. 3 (2006), s. 243-252 ISSN 0011-4626 R&D Projects: GA MŠk 1P04LA213 Institutional research plan: CEZ:AV0Z10480505 Keywords : ADS * MCNPX * spallation Subject RIV: BG - Nuclear , Atomic and Molecular Physics, Colliders Impact factor: 0.568, year: 2006

Decontaminating lead bricks and shielding

International Nuclear Information System (INIS)

Lussiez, G.

1994-01-01

Lead used for shielding is often surface contaminated with radioisotopes and is therefore a RCRA D008 mixed waste. The technology-based standard for treatment is macroencapsulation. However, decontaminating and recycling the clean lead is a more attractive solution. Los Alamos National Laboratory decontaminates material and equipment contaminated with radioisotopes. Decontaminating lead poses special problems because of the RCRA hazard classification and the size of the inventory, now about 50 tons and likely to grow substantially of planned decommissioning operations. Thus lead, in the form of bricks and other shield shapes, is surface contaminated with fission products. One of the best methods for contaminated lead is removing the superficial layer of contamination with an abrasive medium under pressure. For lead, a mixture of alumina with water and air at about 40 psig rapidly and effectively decontaminates the lead. The abrasive medium is sprayed onto the lead in a scaled-off area. The slurry of abrasive and particles of lead falls through a floor and is collected in a sump. A pump sends the slurry mixture back to the spray gun, creating a continuous process. The process generates small volumes of lead slurry that can be solidified and, because it passes the TCLP, is not a mixed waste. The decontaminated lead can be released for recycling

High-temperature superconducting current leads

Science.gov (United States)

Hull, J. R.

1992-07-01

The use of high-temperature superconductors (HTSs) for current leads to deliver power to devices at liquid helium temperature is near commercial realization. The use of HTSs in this application has the potential to reduce refrigeration requirements and helium boiloff to values significantly lower than the theoretical best achievable with conventional leads. Considerable advantage is achieved by operating these leads with an intermediate temperature heat sink. The HTS part of the lead can be made from pressed and sintered powder. Powder-in-tube fabrication is also possible, however, the normal metal part of the lead acts as a thermal short and cannot provide much stabilization without increasing the refrigeration required. Lead stability favors designs with low current density. Such leads can be manufactured with today's technology, and lower refrigeration results from the same allowable burnout time. Higher current densities result in lower boiloff for the same lead length, but bumout times can be very short. In comparing experiment to theory, the density of helium vapor needs to be accounted for in calculating the expected boiloff. For very low-loss leads, two-dimensional heat transfer and the state of the dewar near the leads may play a dominant role in lead performance.

Lead, arsenic, and copper content of crops grown on lead arsenate-treated and untreated soils

Energy Technology Data Exchange (ETDEWEB)

Chisholm, D

1972-01-01

Increased lead and arsenic concentrations in the surface soil (0-15 cm), resulting from applications of lead arsenate (PbHAs0/sub 1/), increased both lead and arsenic levels in crops grown on treated plots. The lead levels in some crops approached or exceeded the Canadian residue tolerance of 2.0 ppM. Lead arsenate soil treatments did not affect copper absorption by crops. On areas such as old orchard land contaminated with lead arsenate residues it may be advisable to ascertain crops, and also to determine the lead affinity and arsenic sensitivity of the plants to be grown.

Lead poisoning in dogs

International Nuclear Information System (INIS)

Zook, B.C.; Carpenter, J.L.; Leeds, E.B.

1969-01-01

Lead poisoning was diagnosed and studied in 60 dogs. It was found that lead poisoning is a common disease of young dogs, especially in the summer and fall, and is related to their chewing and eating habits resulting in the ingestion of paint, linoleum, or other lead-containing materials. The signs were characterized by gastrointestinal dysfunction (colic, vomiting, and diarrhea) and nervous disorders (convulsions, hysteria, nervousness, behavioral changes). The blood findings, which the authors consider nearly pathognomonic, consisted of numerous stippled and immature (especially nucleated) erythrocytes in the absence of severe anemia. Protein and casts were frequently found in the urine. Radiography sometimes revealed lead-containing particles in the gastro-intestinal tract, and lead lines were occasionally detected in the metaphysis of long bones in immature dogs. Treatment with calcium ethylenediamine-tetraacetic acid resulted in rapid and often dramatic recoveries in nearly all instances. Removal of lead from the gastrointestinal tract and treatment to relieve pronounced central nervous disorders was sometimes necessary. 40 references, 6 figures, 7 tables

ALICE: Simulated lead-lead collision

CERN Multimedia

2003-01-01

This track is an example of simulated data modelled for the ALICE detector on the Large Hadron Collider (LHC) at CERN, which will begin taking data in 2008. ALICE will focus on the study of collisions between nuclei of lead, a heavy element that produces many different particles when collided. It is hoped that these collisions will produce a new state of matter known as the quark-gluon plasma, which existed billionths of a second after the Big Bang.

Experimental lead poisoning in chickens

Energy Technology Data Exchange (ETDEWEB)

Silven, L.

1967-01-01

Poisoning of water fowl due to the intake of lead shot is not rare in the USA. In order to study this kind of poisoning more closely domestic fowl were given varying amounts of lead shot and lead powder. This treatment did not provoke any symptoms of poisoning. Chemical analyses of different organs, muscles, skeleton and eggs yielded low lead values. It is concluded that the low toxicity of lead administered as lead shot to the domestic fowl is due to a low absorption rate from the gastro-intestinal tract.

Bone lead levels and lead isotope ratios in red grouse from Scottish and Yorkshire moors

Energy Technology Data Exchange (ETDEWEB)

Thomas, Vernon G., E-mail: vthomas@uoguelph.ca [Department of Integrative Biology, College of Biological Science, University of Guelph, Guelph, Ontario, N1G 2W1 (Canada); Scheuhammer, Anton M.; Bond, Della E. [Metals Toxicology Laboratory, National Wildlife Research Centre, Carleton University, Ottawa, Ontario, K1A 0H3 (Canada)

2009-05-15

Leg and foot bones of adult and juvenile red grouse (Lagopus lagopus scoticus) were collected from hunter-shot birds on two Scottish estates (Glendye and Invermark) and one Yorkshire estate in September, 2003. The lead content of bones was measured by atomic absorption spectrophotometry, and corresponding stable lead isotopes (Pb204, 206, 207, 208) by inductively coupled plasma mass spectrometry. At the Glendye (N = 111) and Invermark (N = 85) estates, relatively few birds (5.4% and 3.5%, respectively) had highly elevated bone lead concentrations (> 20 mug/g dry weight). In bones of these highly exposed birds, a combination of Pb206:Pb207 and Pb208:Pb207ratios was consistent with ingestion of lead gunshot available in Europe. By contrast, Yorkshire grouse experienced a high incidence (65.8%) of bone lead > 20 mug/g. The Pb206:Pb207 and Pb208:Pb207ratios in bones of these highly exposed birds were consistent with a combined exposure to ingested lead gunshot and lead from galena mining in the region. Lead isotope ratios also indicated that lead from UK gasoline combustion and fallout from atmospheric particles was not a likely source of elevated lead in bones of either Scottish or Yorkshire grouse. Suggested management options for the three moors include adopting nontoxic shot for all game shooting on the estates, allowing heather (Calluna vulgaris) vegetation to grow tall in lead shot fall-out zones to reduce physical access to high densities of lead shot already present, and provision of calcareous grit across moors to reduce lead assimilation from all ingested sources of lead.

The effect of interior lead hazard controls on children's blood lead concentrations: a systematic evaluation.

Science.gov (United States)

Haynes, Erin; Lanphear, Bruce P; Tohn, Ellen; Farr, Nick; Rhoads, George G

2002-01-01

Dust control is often recommended to prevent children's exposure to residential lead hazards, but the effect of these controls on children's blood lead concentrations is uncertain. We conducted a systematic review of randomized, controlled trials of low-cost, lead hazard control interventions to determine the effect of lead hazard control on children's blood lead concentration. Four trials met the inclusion criteria. We examined mean blood lead concentration and elevated blood lead concentrations (> or = 10 microg/dL, > or = 15 microg/dL, and > or = 20 microg/dL) and found no significant differences in mean change in blood lead concentration for children by random group assignment (children assigned to the intervention group compared with those assigned to the control group). We found no significant difference between the intervention and control groups in the percentage of children with blood lead > or = 10 microg/dL, 29% versus 32% [odds ratio (OR), 0.85; 95% confidence interval (CI), 0.56-1.3], but there was a significant difference in the percentage of children with blood lead > or = 15 microg/dL between the intervention and control groups, 6% versus 14% (OR, 0.40; 95% CI, 0.21-0.80) and in the percentage of children with blood lead > or = 20 microg/dL between the intervention and control groups, 2% versus 6% (OR, 0.29; 95% CI, 0.10-0.85). We conclude that although low-cost, interior lead hazard control was associated with 50% or greater reduction in the proportion of children who had blood lead concentrations exceeding 15 microg/dL and > or = 20 microg/dL, there was no substantial effect on mean blood lead concentration.

Bone lead levels and lead isotope ratios in red grouse from Scottish and Yorkshire moors

International Nuclear Information System (INIS)

Thomas, Vernon G.; Scheuhammer, Anton M.; Bond, Della E.

2009-01-01

Leg and foot bones of adult and juvenile red grouse (Lagopus lagopus scoticus) were collected from hunter-shot birds on two Scottish estates (Glendye and Invermark) and one Yorkshire estate in September, 2003. The lead content of bones was measured by atomic absorption spectrophotometry, and corresponding stable lead isotopes (Pb204, 206, 207, 208) by inductively coupled plasma mass spectrometry. At the Glendye (N = 111) and Invermark (N = 85) estates, relatively few birds (5.4% and 3.5%, respectively) had highly elevated bone lead concentrations (> 20 mug/g dry weight). In bones of these highly exposed birds, a combination of Pb206:Pb207 and Pb208:Pb207ratios was consistent with ingestion of lead gunshot available in Europe. By contrast, Yorkshire grouse experienced a high incidence (65.8%) of bone lead > 20 mug/g. The Pb206:Pb207 and Pb208:Pb207ratios in bones of these highly exposed birds were consistent with a combined exposure to ingested lead gunshot and lead from galena mining in the region. Lead isotope ratios also indicated that lead from UK gasoline combustion and fallout from atmospheric particles was not a likely source of elevated lead in bones of either Scottish or Yorkshire grouse. Suggested management options for the three moors include adopting nontoxic shot for all game shooting on the estates, allowing heather (Calluna vulgaris) vegetation to grow tall in lead shot fall-out zones to reduce physical access to high densities of lead shot already present, and provision of calcareous grit across moors to reduce lead assimilation from all ingested sources of lead.

Decontaminating lead bricks and shielding

International Nuclear Information System (INIS)

Lussiez, G.W.

1993-01-01

Lead used for shielding is often surface contaminated with radioisotopes and is therefore a RCRA D008 mixed waste. The technology-based standard for treatment is macroencapsulation. However, decontaminating and recycling the clean lead is a more attractive solution. Los Alamos National Laboratory decontaminates material and equipment contaminated with radioisotopes. Decontaminating lead poses special problems because of the RCRA hazard classification and the size of the inventory, now about 50 tons and likely to grow substantially because of planned decommissioning operations. This lead, in the form of bricks and other shield shapes, is surface contaminated with fission products. One of the best methods for decontaminating lead is removing the thin superficial layer of contamination with an abrasive medium trader pressure. For lead, a mixture of alumina with water and air at about 40 psig rapidly and effectively decontaminates the lead. The abrasive medium is sprayed onto the lead in a sealed-off area. The slurry of abrasive and particles of lead falls through a floor grating and is collected in a sump. A pump sends the slurry mixture back to the spray gun, creating a continuous process. The process generates small volumes of contaminated lead slurry that can be solidified and, because it passes the TCLP, is not a mixed waste. The decontaminated lead can be released for recycling

Lead contamination and transfer in urban environmental compartments analyzed by lead levels and isotopic compositions.

Science.gov (United States)

Hu, Xin; Sun, Yuanyuan; Ding, Zhuhong; Zhang, Yun; Wu, Jichun; Lian, Hongzhen; Wang, Tijian

2014-04-01

Lead levels and isotopic compositions in atmospheric particles (TSP and PM2.5), street dust and surface soil collected from Nanjing, a mega city in China, were analyzed to investigate the contamination and the transfer of lead in urban environmental compartments. The lead contents in TSP and PM2.5 are significantly higher than them in the surface soil and street dust (p lead to the major crustal elements (Al, Sr, Ti and Fe) indicates significant lead enrichment in atmospheric particles. The plots of (206)Pb/(207)Pb vs.(208)Pb/(206)Pb and (206)Pb/(207)Pb vs. 1/Pb imply that the street dust and atmospheric particles (TSP and PM2.5) have very similar lead sources. Coal emissions and smelting activities may be the important lead sources for street dust and atmospheric particles (TSP and PM2.5), while the deposition of airborne lead is an important lead source for urban surface soil. Copyright © 2013 Elsevier Ltd. All rights reserved.

INAA, AAS, and lead isotope analysis of ancient lead anchors from the black SEA

International Nuclear Information System (INIS)

Kuleff, I.; Djingova, R.; Alexandrova, A.

1995-01-01

Lead stock of wooden-lead anchors found along the Bulgarian Black Sea coast and typo logically dated VI c. B.C. - III c. A.D. have been analyzed for chemical composition and lead isotope ratios by INAA, AAS and mass spectrometry. Using multivariate methods for analysis as well as simple bi variate plots the lead for production of the stocks was localized as originating from Laurion, Thassos, Troas, Chalkidike and the Rhodopes. In general, the chemical composition is not recommended to be used for provenance study of lead artefacts. Combining the results from this study with the existing typo logical classification certain conclusion about the production and distribution of lead anchors in the Aegean region are made. (author). 22 refs., 3 figs., 4 tabs

Evaluation of containment peak pressure and structural response for a large-break loss-of-coolant accident in a VVER-440/213 NPP

Energy Technology Data Exchange (ETDEWEB)

Spencer, B.W.; Sienicki, J.J.; Kulak, R.F.; Pfeiffer, P.A. [Argonne National Lab., IL (United States); Voeroess, L.; Techy, Z. [VEIKI Inst. for Electric Power Research, Budapest (Hungary); Katona, T. [Paks Nuclear Power Plant (Hungary)

1998-07-01

A collaborative effort between US and Hungarian specialists was undertaken to investigate the response of a VVER-440/213-type NPP to a maximum design-basis accident, defined as a guillotine rupture with double-ended flow from the largest pipe (500 mm) in the reactor coolant system. Analyses were performed to evaluate the magnitude of the peak containment pressure and temperature for this event; additional analyses were performed to evaluate the ultimate strength capability of the containment. Separate cases were evaluated assuming 100% effectiveness of the bubbler-condenser pressure suppression system as well as zero effectiveness. The pipe break energy release conditions were evaluated from three sources: (1) FSAR release rate based on Soviet safety calculations, (2) RETRAN-03 analysis and (3) ATHLET analysis. The findings indicated that for 100% bubbler-condenser effectiveness the peak containment pressures were less than the containment design pressure of 0.25 MPa. For the BDBA case of zero effectiveness of the bubbler-condenser system, the peak pressures were less than the calculated containment failure pressure of 0.40 MPa absolute.

Atrioventricular Pacemaker Lead Reversal

Directory of Open Access Journals (Sweden)

Mehmet K Aktas, MD

2007-01-01

Full Text Available During cardiac surgery temporary epicardial atrial and ventricular leads are placed in case cardiac pacing is required postoperatively. We present the first reported series of patients with reversal of atrioventricular electrodes in the temporary pacemaker without any consequent deleterious hemodynamic effect. We review the electrocardiographic findings and discuss the findings that lead to the discovery of atrioventricular lead reversal.

Lead accumulation in the straw mushroom, Volvariella volvacea, from lead contaminated rice straw and stubble.

Science.gov (United States)

Kumhomkul, Thapakorn; Panich-pat, Thanawan

2013-08-01

Straw mushrooms were grown on lead contaminated rice straw and stubble. Study materials were dried, acid digested, and analyzed for lead using flame atomic absorption spectrophotometry. The results showed the highest lead concentration in substrate was 445.350 mg kg⁻¹ in Treatment 3 (T3) and the lowest was BD (below detection) in Treatment 1 (T1). The maximum lead content in straw mushrooms was 5.072 mg kg⁻¹ dw in pileus of T3 and the minimum lead content in straw mushrooms was BD in egg and mature (stalk and pileus) stage of T1. The lead concentration in straw mushrooms was affected by the age of the mycelium and the morphology of mushrooms. Mushrooms' lead uptake produced the highest accumulation in the cell wall. Some lead concentrations in straw mushrooms exceeded the EU standard (>3 mg kg⁻¹ dw).

Application of the associated particle method to the determination of the efficiency of an NE 213 detection assembly with 750 keV neutrons. Utilization of a velocity filter

International Nuclear Information System (INIS)

Becret, Claude.

1979-01-01

This report presents the calibration of a neutron detection set, fitted with an NE 213 organic scintillator. This calibration uses the associated particle method, by means of the 3 T(p,n) 3 He reaction producing 750 keV neutrons. A separator device, of the velocity filter type, is employed for separating the heliums -emitted during the 3 T(p,n) 3 He neutron generating reaction- from the charged particles emanating from competing or spurious reactions. The calibration of this set enables neutron fluences of between 700 keV and 1 MeV in energy to be determined. The knowledge of such fluences is essential for dosimetry studies and for determining the sensitivity of weapons systems or components to nuclear radiation effects [fr

Basic principles of lead and lead-bismuth eutectic application in blanket of fusion reactors

International Nuclear Information System (INIS)

Beznosov, A.V.; Pinaev, S.S.; Muraviev, E.V.; Romanov, P.V.

2005-01-01

High magnetohydrodynamic pressure drop is an important issue for liquid metal blanket concepts. To decrease magnetohydrodynamic resistance authors propose to form insulating coatings on internal surface of blanket ducts at any moment of fusion reactor exploitation. It may be achieved easily if lead or lead-bismuth eutectic is used and technology of oxidative potential handling is applied. A number of experiments carried out in NNSTU show the availability of the proposed technology. It bases on formation of the insulating coatings that consist of the oxides of components of the structural materials and of the coolant components. In-situ value of the insulating coatings characteristics ρδ is ∼ 10 -5 Ohm·m 2 for steels and 5,0x10 -6 - 5,0x10 -5 Ohm·m 2 for vanadium alloys. Thermal cycling is possible during exploitation of a blanket. The experimental research of the insulating coatings properties during thermal cycling have shown that the coatings formed into the lead and lead-bismuth coolants save there insulating properties. Experience of many years is an undoubted advantage of the lead-bismuth coolant and less of the lead coolant in comparison with lithium. Russian Federation possesses of experience of exploitation of the research and industrial facilities, of experience of creation of the pumps, steamgenerators and equipment with heavy liquid metal coolants. The unique experience of designing, assembling and exploitation of the fission reactors with lead-bismuth coolant is also available. The problem of technology of lead and lead-bismuth coolants for power high temperature radioactive facilities has been solved. Accidents, emergency situations such as leakage of steamgenerators or depressurization of gas system in facilities with lead and lead-bismuth coolants have been explored and suppressed. (author)

Manurial properties of lead nitrate

Energy Technology Data Exchange (ETDEWEB)

Berry, R A

1924-01-01

Water culture, pot and field experiments were conducted in order to determine the toxic and stimulating limit of lead nitrate in solution. Oats and rye grass were evaluated for evidence of lead poisoning. Results indicate that except in solutions of fairly high concentration, soil adsorbs the lead and destroys the toxicity of soluble lead salts. There was evidence to show that the addition of lead salts increased the rate of nitrification in soil.

Children’s Blood Lead Seasonality in Flint, Michigan (USA), and Soil-Sourced Lead Hazard Risks

Science.gov (United States)

Laidlaw, Mark A.S.; Filippelli, Gabriel M.; Sadler, Richard C.; Gonzales, Christopher R.; Ball, Andrew S.; Mielke, Howard W.

2016-01-01

In Flint; MI; USA; a public health crisis resulted from the switching of the water supply from Lake Huron to a more corrosive source from the Flint River in April 2014; which caused lead to leach from water lines. Between 2010 and 2015; Flint area children’s average blood lead patterns display consistent peaks in the third quarter of the year. The third quarter blood lead peaks displayed a declining trend between 2010 and 2013; then rose abruptly between the third quarters of 2013 from 3.6% blood lead levels ≥5 µg/dL to a peak of about 7% in the third quarter of 2014; an increase of approximately 50%. The percentage of blood lead level ≥5 µg/dL in the first quarter of 2015 then dropped to 2.3%; which was the same percentage as the first quarter of 2014 (prior to the Flint River water source change). The Flint quarterly blood lead level peak then rose to about 6% blood lead levels ≥ 5 µg/dL in the third quarter of 2015; and then declined to about 2.5% in the fourth quarter of 2015. Soil lead data collected by Edible Flint food collaborative reveal generally higher soil lead values in the metropolitan center for Flint; with lower values in the outskirts of the city. The questions that are not being asked is why did children’s blood lead levels display a seasonal blood lead pattern before the introduction of the new water supply in Flint; and what are the implications of these seasonal blood lead patterns? Based upon previous findings in Detroit and other North American cities we infer that resuspension to the air of lead in the form of dust from lead contaminated soils in Flint appears to be a persistent contribution to lead exposure of Flint children even before the change in the water supply from Lake Huron to the Flint River. PMID:27023578

Magnesium Diboride Current Leads

Science.gov (United States)

Panek, John

2010-01-01

A recently discovered superconductor, magnesium diboride (MgB2), can be used to fabricate conducting leads used in cryogenic applications. Dis covered to be superconducting in 2001, MgB2 has the advantage of remaining superconducting at higher temperatures than the previously used material, NbTi. The purpose of these leads is to provide 2 A of electricity to motors located in a 1.3 K environment. The providing environment is a relatively warm 17 K. Requirements for these leads are to survive temperature fluctuations in the 5 K and 11 K heat sinks, and not conduct excessive heat into the 1.3 K environment. Test data showed that each lead in the assembly could conduct 5 A at 4 K, which, when scaled to 17 K, still provided more than the required 2 A. The lead assembly consists of 12 steelclad MgB2 wires, a tensioned Kevlar support, a thermal heat sink interface at 4 K, and base plates. The wires are soldered to heavy copper leads at the 17 K end, and to thin copper-clad NbTi leads at the 1.3 K end. The leads were designed, fabricated, and tested at the Forschungszentrum Karlsruhe - Institut foer Technische Physik before inclusion in Goddard's XRS (X-Ray Spectrometer) instrument onboard the Astro-E2 spacecraft. A key factor is that MgB2 remains superconducting up to 30 K, which means that it does not introduce joule heating as a resistive wire would. Because the required temperature ranges are 1.3-17 K, this provides a large margin of safety. Previous designs lost superconductivity at around 8 K. The disadvantage to MgB2 is that it is a brittle ceramic, and making thin wires from it is challenging. The solution was to encase the leads in thin steel tubes for strength. Previous designs were so brittle as to risk instrument survival. MgB2 leads can be used in any cryogenic application where small currents need to be conducted at below 30 K. Because previous designs would superconduct only at up to 8 K, this new design would be ideal for the 8-30 K range.

Determination of lead in whole blood: Comparison of the LeadCare blood lead testing system with zeeman longitudinal electrothermal atomic absorption spectrometry

International Nuclear Information System (INIS)

Pineau, A.; Viallefont, A.; Fauconneau, B.; Rafael, M.; Guillard, O.

2002-01-01

This study compares the efficiency of blood lead level analysis by graphite furnace atomic absorption spectrometry (GFAAS) and the portable LeadCare Blood lead testing system (LCS). Recoveries of two added lead concentrations of 22 and 42 μg/dL ranged from 102.4 to 105.5% for LCS and from 96.3 to 97.2% for GFAAS. Measurement of a certified sample (Certified Danish Whole Blood) at a blood lead concentration of 26.2 μg/dL gave within- and between-run coefficients of variation which were both approximately 8% by LCS and 2% by GFAAS. Comparison of the tested method (LCS) versus GFAAS from analysis of 76 samples of blood lead collected from workers in different industrial sectors showed imperfect overall correlation (r = 0.95). The LCS is quite suitable for screening purposes, but requires the use of non-frozen blood collected less than 24 h before. Conservative threshold values should be applied when using the LCS for initial screening in the field. (orig.)

Archives of Atmospheric Lead Pollution

Science.gov (United States)

Weiss, Dominik; Shotyk, William; Kempf, Oliver

Environmental archives such as peat bogs, sediments, corals, trees, polar ice, plant material from herbarium collections, and human tissue material have greatly helped to assess both ancient and recent atmospheric lead deposition and its sources on a regional and global scale. In Europe detectable atmospheric lead pollution began as early as 6000years ago due to enhanced soil dust and agricultural activities, as studies of peat bogs reveal. Increased lead emissions during ancient Greek and Roman times have been recorded and identified in many long-term archives such as lake sediments in Sweden, ice cores in Greenland, and peat bogs in Spain, Switzerland, the United Kingdom, and the Netherlands. For the period since the Industrial Revolution, other archives such as corals, trees, and herbarium collections provide similar chronologies of atmospheric lead pollution, with periods of enhanced lead deposition occurring at the turn of the century and since 1950. The main sources have been industry, including coal burning, ferrous and nonferrous smelting, and open waste incineration until c.1950 and leaded gasoline use since 1950. The greatest lead emissions to the atmosphere all over Europe occurred between 1950 and 1980 due to traffic exhaust. A marked drop in atmospheric lead fluxes found in most archives since the 1980s has been attributed to the phasing out of leaded gasoline. The isotope ratios of lead in the various archives show qualitatively similar temporal changes, for example, the immediate response to the introduction and phasing out of leaded gasoline. Isotope studies largely confirm source assessments based on lead emission inventories and allow the contributions of various anthropogenic sources to be calculated.

Decontaminating lead bricks and shielding

International Nuclear Information System (INIS)

Lussiez, G.W.

1993-01-01

Lead used for shielding is often surface contaminated with radionuclides and is therefore a Resource Conservation and Recovery Act (RCRA) D008 mixed waste. The technology-based standard for treatment is macroencapsulation. However, decontaminating and recycling the clean lead is a more attractive solution. Los Alamos National Lab. decontaminates material and equipment contaminated with radioisotopes. Decontaminating lead poses special problems because of the RCRA hazard classification and the size of the inventory, now about 100 metric tons and likely to grow substantially because of planned decommissioning operations. This lead, in the form of bricks and other shield shapes, is surface contaminated with fission products. One of the best methods for decontaminating lead is removing the thin superficial layer of contamination with an abrasive medium under pressure. For lead, a mixture of alumina with water and air at about 280 kPa (40 psig) rapidly and effectively decontaminates the lead. The abrasive medium is sprayed onto the lead in a sealed-off area. The slurry of abrasive and particles of lead falls through a floor grating and is collected in a pump. A pump sends the slurry mixture back to the spray gun, creating a continuous process